BLASTP 2.2.25+


Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.



Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.



Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
           15,229,318 sequences; 5,219,829,388 total letters



Query= Rv3066

Length=202
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

gi|15610203|ref|NP_217582.1|  DeoR family transcriptional regulat...   394    3e-108
gi|240170695|ref|ZP_04749354.1|  transcriptional regulatory prote...   256    1e-66 
gi|118618738|ref|YP_907070.1|  transcriptional regulatory protein...   248    3e-64 
gi|259090351|pdb|3IUV|A  Chain A, The Structure Of A Member Of Te...   112    4e-23 
gi|337763592|emb|CCB72302.1|  Transcriptional regulatory protein ...   111    5e-23 
gi|291440360|ref|ZP_06579750.1|  TetR-family transcriptional regu...   111    6e-23 
gi|21220404|ref|NP_626183.1|  hypothetical protein SCO1917 [Strep...   111    6e-23 
gi|300508406|pdb|3HTA|A  Chain A, Crystal Structure Of Multidrug ...   111    6e-23 
gi|297198854|ref|ZP_06916251.1|  ebrA repressor [Streptomyces svi...   108    3e-22 
gi|300789381|ref|YP_003769672.1|  TetR family transcriptional reg...   107    1e-21 
gi|302533771|ref|ZP_07286113.1|  ebrA repressor [Streptomyces sp....   105    5e-21 
gi|294628707|ref|ZP_06707267.1|  transcriptional regulatory prote...   103    1e-20 
gi|302550604|ref|ZP_07302946.1|  TetR family transcriptional regu...   102    2e-20 
gi|290961362|ref|YP_003492544.1|  repressor [Streptomyces scabiei...   100    9e-20 
gi|29832878|ref|NP_827512.1|  TetR family transcriptional regulat...  99.4    3e-19 
gi|320011459|gb|ADW06309.1|  transcriptional regulator, TetR fami...  98.2    6e-19 
gi|302546314|ref|ZP_07298656.1|  TetR family transcriptional regu...  97.4    1e-18 
gi|294632913|ref|ZP_06711472.1|  conserved hypothetical protein [...  96.7    2e-18 
gi|326780054|ref|ZP_08239319.1|  transcriptional regulator, TetR ...  95.9    3e-18 
gi|344998942|ref|YP_004801796.1|  TetR family transcriptional reg...  94.0    1e-17 
gi|328881595|emb|CCA54834.1|  Transcriptional regulator, TetR fam...  93.6    1e-17 
gi|262201944|ref|YP_003273152.1|  TetR family transcriptional reg...  91.3    7e-17 
gi|182439398|ref|YP_001827117.1|  TetR family transcriptional reg...  90.9    1e-16 
gi|254384161|ref|ZP_04999505.1|  ebrA repressor [Streptomyces sp....  88.2    6e-16 
gi|257057139|ref|YP_003134971.1|  hypothetical protein Svir_31710...  88.2    6e-16 
gi|269219739|ref|ZP_06163593.1|  putative transcriptional regulat...  87.8    8e-16 
gi|296137890|ref|YP_003645133.1|  TetR family transcriptional reg...  87.4    1e-15 
gi|326383954|ref|ZP_08205638.1|  regulatory protein TetR [Gordoni...  86.7    2e-15 
gi|333920137|ref|YP_004493718.1|  hypothetical protein AS9A_2471 ...  85.9    3e-15 
gi|295839578|ref|ZP_06826511.1|  TetR family transcriptional regu...  84.3    8e-15 
gi|318056391|ref|ZP_07975114.1|  hypothetical protein SSA3_00505 ...  83.2    2e-14 
gi|311280270|ref|YP_003942501.1|  transcriptional regulator, TetR...  83.2    2e-14 
gi|302518364|ref|ZP_07270706.1|  ebrA repressor [Streptomyces sp....  82.8    3e-14 
gi|333027966|ref|ZP_08456030.1|  hypothetical protein STTU_5470 [...  82.0    4e-14 
gi|260597241|ref|YP_003209812.1|  HTH-type transcriptional regula...  82.0    5e-14 
gi|157146502|ref|YP_001453820.1|  hypothetical protein CKO_02263 ...  81.6    6e-14 
gi|271969071|ref|YP_003343267.1|  TetR family transcriptional reg...  80.9    9e-14 
gi|146310995|ref|YP_001176069.1|  TetR family transcriptional reg...  80.5    1e-13 
gi|239986856|ref|ZP_04707520.1|  TetR family transcriptional regu...  80.5    1e-13 
gi|134103635|ref|YP_001109296.1|  putative DeoR-type transcriptio...  80.5    1e-13 
gi|170768984|ref|ZP_02903437.1|  transcriptional regulator, TetR ...  79.3    3e-13 
gi|297560633|ref|YP_003679607.1|  TetR family transcriptional reg...  79.3    3e-13 
gi|257057801|ref|YP_003135633.1|  hypothetical protein Svir_38620...  78.2    7e-13 
gi|302531180|ref|ZP_07283522.1|  predicted protein [Streptomyces ...  77.8    8e-13 
gi|283784609|ref|YP_003364474.1|  TetR family transcriptional reg...  77.8    8e-13 
gi|336249446|ref|YP_004593156.1|  putative DeoR-type transcriptio...  77.8    9e-13 
gi|324112718|gb|EGC06694.1|  tetR family protein regulatory prote...  77.8    9e-13 
gi|134101872|ref|YP_001107533.1|  TetR family transcriptional reg...  77.4    1e-12 
gi|333955922|gb|EGL73629.1|  hypothetical protein CSE899_05067 [C...  77.4    1e-12 
gi|345014301|ref|YP_004816655.1|  TetR family transcriptional reg...  77.4    1e-12 


>gi|15610203|ref|NP_217582.1| DeoR family transcriptional regulator [Mycobacterium tuberculosis 
H37Rv]
 gi|15842635|ref|NP_337672.1| hypothetical protein MT3151 [Mycobacterium tuberculosis CDC1551]
 gi|31794245|ref|NP_856738.1| DeoR family transcriptional regulator [Mycobacterium bovis AF2122/97]
 78 more sequence titles
 Length=202

 Score =  394 bits (1013),  Expect = 3e-108, Method: Compositional matrix adjust.
 Identities = 201/202 (99%), Positives = 202/202 (100%), Gaps = 0/202 (0%)

Query  1    LTAGSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDA  60
            +TAGSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDA
Sbjct  1    MTAGSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDA  60

Query  61   LREAALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAH  120
            LREAALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAH
Sbjct  61   LREAALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAH  120

Query  121  RPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIAR  180
            RPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIAR
Sbjct  121  RPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIAR  180

Query  181  LVADGPEQREVGQSAHAGRTPD  202
            LVADGPEQREVGQSAHAGRTPD
Sbjct  181  LVADGPEQREVGQSAHAGRTPD  202


>gi|240170695|ref|ZP_04749354.1| transcriptional regulatory protein [Mycobacterium kansasii ATCC 
12478]
Length=185

 Score =  256 bits (654),  Expect = 1e-66, Method: Compositional matrix adjust.
 Identities = 139/184 (76%), Positives = 157/184 (86%), Gaps = 0/184 (0%)

Query  1    LTAGSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDA  60
            +TA   RRPRDP GRRQAI+EAA RVIAR GLG L+HRRVAAEA+VPVGSTTYYF+DL  
Sbjct  1    MTAEPHRRPRDPVGRRQAIIEAAGRVIARHGLGELTHRRVAAEADVPVGSTTYYFSDLGT  60

Query  61   LREAALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAH  120
            LREAALAHAA ++AD L QWR DLD+  DL  TLARLT  YL D DR+RTL+ELY+AA+H
Sbjct  61   LREAALAHAATSAADWLEQWRRDLDRAADLPVTLARLTAEYLTDPDRHRTLSELYVAASH  120

Query  121  RPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIAR  180
            RPELQ LARLWP+GL+ALLEPRIGRRAA AVTVF DGAT+H+LITGTPLS + LTDA+AR
Sbjct  121  RPELQSLARLWPEGLVALLEPRIGRRAAEAVTVFLDGATVHSLITGTPLSVEALTDAVAR  180

Query  181  LVAD  184
            L AD
Sbjct  181  LAAD  184


>gi|118618738|ref|YP_907070.1| transcriptional regulatory protein [Mycobacterium ulcerans Agy99]
 gi|183981626|ref|YP_001849917.1| transcriptional regulatory protein [Mycobacterium marinum M]
 gi|118570848|gb|ABL05599.1| transcriptional regulatory protein [Mycobacterium ulcerans Agy99]
 gi|183174952|gb|ACC40062.1| transcriptional regulatory protein [Mycobacterium marinum M]
Length=192

 Score =  248 bits (634),  Expect = 3e-64, Method: Compositional matrix adjust.
 Identities = 126/184 (69%), Positives = 148/184 (81%), Gaps = 0/184 (0%)

Query  1    LTAGSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDA  60
            +T   +RRPRDPAGRRQ I+EAA R+IAR GLG L+HRRVAAEA+VPVGSTTYYF+DL  
Sbjct  1    MTREVERRPRDPAGRRQTIIEAAGRLIARHGLGDLTHRRVAAEADVPVGSTTYYFSDLGE  60

Query  61   LREAALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAH  120
            LREAALAH A ++ D L  W  DLD+  D+ ATLARLT  YL D DR+RTLNELY+AA+H
Sbjct  61   LREAALAHVATSATDWLEHWERDLDESTDIPATLARLTADYLTDPDRHRTLNELYVAASH  120

Query  121  RPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIAR  180
            +PELQ LA+LW DGL+ALLEPRIG RAA  V++F DGATLHA+I+ TPL    LTDAIAR
Sbjct  121  QPELQSLAQLWSDGLVALLEPRIGPRAARVVSIFLDGATLHAMISDTPLDAPALTDAIAR  180

Query  181  LVAD  184
            LV +
Sbjct  181  LVGN  184


>gi|259090351|pdb|3IUV|A Chain A, The Structure Of A Member Of Tetr Family (Sco1917) From 
Streptomyces Coelicolor A3
Length=201

 Score =  112 bits (279),  Expect = 4e-23, Method: Compositional matrix adjust.
 Identities = 74/180 (42%), Positives = 102/180 (57%), Gaps = 2/180 (1%)

Query  4    GSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALRE  63
            G   R  DP  RRQ I++AA RV+ ++G+ GLSHR VAAEA+VP+GSTTY+F  LD L  
Sbjct  1    GHXPRRHDPE-RRQRIIDAAIRVVGQKGIAGLSHRTVAAEADVPLGSTTYHFATLDDLXV  59

Query  64   AALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRP  122
            AAL  A    A ++A   +  D + DL+  LAR+   +L  D+       ELY+AA  RP
Sbjct  60   AALRQANEGFARVVAAHPALSDPEADLSGELARVLGEWLGGDRTGVELEYELYLAALRRP  119

Query  123  ELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
             L+ +A  W +G+ ALL  R     A A+    DG  L  L+T TP   +   + + RL+
Sbjct  120  ALRPVAAEWAEGVGALLAARTDPTTARALVAVLDGICLQVLLTDTPYDEEYAREVLTRLI  179


>gi|337763592|emb|CCB72302.1| Transcriptional regulatory protein [Streptomyces cattleya NRRL 
8057]
Length=194

 Score =  111 bits (278),  Expect = 5e-23, Method: Compositional matrix adjust.
 Identities = 82/170 (49%), Positives = 97/170 (58%), Gaps = 0/170 (0%)

Query  18   AIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASADLL  77
            AIVEAA  +I   G+ GLSHR VAA A VP+G+TTYYF DL  L  AAL HAA    + L
Sbjct  20   AIVEAACALIPDTGIHGLSHRLVAARAGVPLGATTYYFTDLADLSRAALEHAAARWTEEL  79

Query  78   AQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRPELQRLARLWPDGLLA  137
              W + L    D+ A LA L   Y  D+ R     ELY AAA RPEL+ LA LW DGL+ 
Sbjct  80   RAWATALRDSDDVPAALAALAARYAEDRPRALIEAELYTAAARRPELRPLAHLWFDGLVR  139

Query  138  LLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADGPE  187
            +L       AA A  +  DGA L AL    P+   ELT A+  L+ DGPE
Sbjct  140  VLRAHTTPAAATATALLLDGALLRALRDEDPVDVTELTAALRTLMGDGPE  189


>gi|291440360|ref|ZP_06579750.1| TetR-family transcriptional regulator [Streptomyces ghanaensis 
ATCC 14672]
 gi|291343255|gb|EFE70211.1| TetR-family transcriptional regulator [Streptomyces ghanaensis 
ATCC 14672]
Length=181

 Score =  111 bits (278),  Expect = 6e-23, Method: Compositional matrix adjust.
 Identities = 75/176 (43%), Positives = 98/176 (56%), Gaps = 2/176 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA RV+ R G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  4    RRHDPE-RRQRIIDAAIRVVGRGGIAGLSHRSAAAEADVPLGSTTYHFKTLDELLVAALR  62

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQR  126
                  A  +A  R+ +D   DLAA LA L   +LA +     L  ELY+AA  RP L+ 
Sbjct  63   QTNEGFAKAVAARRTLMDPRTDLAAELAALIGEWLAGERTGVELEYELYLAALRRPALRP  122

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            +A  W + +  LL  R     A A+    DG  L  L+TG P   +   + +AR+V
Sbjct  123  VAAEWCEEVTELLSRRTDPVTARALVALMDGICLQVLLTGGPYDEEYAREMMARIV  178


>gi|21220404|ref|NP_626183.1| hypothetical protein SCO1917 [Streptomyces coelicolor A3(2)]
 gi|289772362|ref|ZP_06531740.1| ebrA repressor [Streptomyces lividans TK24]
 gi|5420026|emb|CAB46418.1| conserved hypothetical protein [Streptomyces coelicolor A3(2)]
 gi|16604268|gb|AAK95485.1| ebrA repressor [Streptomyces lividans]
 gi|289702561|gb|EFD69990.1| ebrA repressor [Streptomyces lividans TK24]
Length=197

 Score =  111 bits (278),  Expect = 6e-23, Method: Compositional matrix adjust.
 Identities = 70/169 (42%), Positives = 98/169 (58%), Gaps = 1/169 (0%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I++AA RV+ ++G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL  A    A
Sbjct  9    RRQRIIDAAIRVVGQKGIAGLSHRTVAAEADVPLGSTTYHFATLDDLMVAALRQANEGFA  68

Query  75   DLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRPELQRLARLWPD  133
             ++A   +  D + DL+  LAR+   +L  D+       ELY+AA  RP L+ +A  W +
Sbjct  69   RVVAAHPALSDPEADLSGELARVLGEWLGGDRTGVELEYELYLAALRRPALRPVAAEWAE  128

Query  134  GLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            G+ ALL  R     A A+    DG  L  L+T TP   +   + + RL+
Sbjct  129  GVGALLAARTDPTTARALVAVLDGICLQVLLTDTPYDEEYAREVLTRLI  177


>gi|300508406|pdb|3HTA|A Chain A, Crystal Structure Of Multidrug Binding Protein Ebrr 
Complexed With Imidazole
 gi|300508407|pdb|3HTA|B Chain B, Crystal Structure Of Multidrug Binding Protein Ebrr 
Complexed With Imidazole
 gi|300508408|pdb|3HTA|C Chain C, Crystal Structure Of Multidrug Binding Protein Ebrr 
Complexed With Imidazole
 7 more sequence titles
 Length=217

 Score =  111 bits (277),  Expect = 6e-23, Method: Compositional matrix adjust.
 Identities = 70/169 (42%), Positives = 98/169 (58%), Gaps = 1/169 (0%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I++AA RV+ ++G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL  A    A
Sbjct  29   RRQRIIDAAIRVVGQKGIAGLSHRTVAAEADVPLGSTTYHFATLDDLMVAALRQANEGFA  88

Query  75   DLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRPELQRLARLWPD  133
             ++A   +  D + DL+  LAR+   +L  D+       ELY+AA  RP L+ +A  W +
Sbjct  89   RVVAAHPALSDPEADLSGELARVLGEWLGGDRTGVELEYELYLAALRRPALRPVAAEWAE  148

Query  134  GLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            G+ ALL  R     A A+    DG  L  L+T TP   +   + + RL+
Sbjct  149  GVGALLAARTDPTTARALVAVLDGICLQVLLTDTPYDEEYAREVLTRLI  197


>gi|297198854|ref|ZP_06916251.1| ebrA repressor [Streptomyces sviceus ATCC 29083]
 gi|197711225|gb|EDY55259.1| ebrA repressor [Streptomyces sviceus ATCC 29083]
Length=183

 Score =  108 bits (271),  Expect = 3e-22, Method: Compositional matrix adjust.
 Identities = 74/179 (42%), Positives = 95/179 (54%), Gaps = 2/179 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA RV+ R+GL GLSHR  AAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  4    RRHDPE-RRQRIIDAAIRVVGRKGLAGLSHRSAAAEADVPLGSTTYHFKSLDELMVAALC  62

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRPELQR  126
             A+   A  +A   +  D   DL A LAR+   +L  D+       ELY+AA  RP L+ 
Sbjct  63   QASEGFAKAVAAHGALDDPGGDLPAGLARVLGDWLGGDRTGVELEYELYLAALRRPALRP  122

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADG  185
            +A  W D L   L  R     A A+    DG  L  L+TG P       +   R++  G
Sbjct  123  VAAEWADDLAERLAHRTDPVTARALVALMDGICLQVLLTGAPYDEGYAREVFGRVIPAG  181


>gi|300789381|ref|YP_003769672.1| TetR family transcriptional regulator [Amycolatopsis mediterranei 
U32]
 gi|299798895|gb|ADJ49270.1| TetR family transcriptional regulator [Amycolatopsis mediterranei 
U32]
 gi|340531028|gb|AEK46233.1| TetR family transcriptional regulator [Amycolatopsis mediterranei 
S699]
Length=192

 Score =  107 bits (267),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 71/181 (40%), Positives = 96/181 (54%), Gaps = 3/181 (1%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            R P DP  RR  I +AA  V+A++G+ G++HR VAA A VP+GSTTY+F  LD L E AL
Sbjct  12   RGPNDPE-RRARIAKAAIEVVAQRGIDGVTHRAVAAAAGVPLGSTTYHFATLDDLLEVAL  70

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQ  125
              AA  +   L +W S L  D D AA LA L   Y+ +Q R   +  +LY+AA HRP L+
Sbjct  71   HEAAERNVHALKEWESALPPDTDFAAALADLVMGYINEQYRDTVVEYDLYVAALHRPALR  130

Query  126  RLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADG  185
            + +  W D L+A    R        +   F G  + A +   P    E  + + R   DG
Sbjct  131  KASAAWDDALIAFFGSRTDPLTGRLLAGLFCGLLMQAAL-ADPRPNREEIETLFRRAIDG  189

Query  186  P  186
            P
Sbjct  190  P  190


>gi|302533771|ref|ZP_07286113.1| ebrA repressor [Streptomyces sp. C]
 gi|302442666|gb|EFL14482.1| ebrA repressor [Streptomyces sp. C]
Length=187

 Score =  105 bits (261),  Expect = 5e-21, Method: Compositional matrix adjust.
 Identities = 75/179 (42%), Positives = 99/179 (56%), Gaps = 11/179 (6%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I++AA RV++ +G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL  A  A A
Sbjct  12   RRQRIIDAAIRVVSAKGIAGLSHRSAAAEADVPLGSTTYHFETLDDLLVAALRQANEAYA  71

Query  75   DLLAQWRSDLDKDRDLAATLARLT-TVYLADQDRYRTLNELYMAAAHRPELQRLARLWPD  133
              L      + +  DLA  LARL   V  AD+ R     ELY+AA  RP L+ +A  W +
Sbjct  72   PALV-----IREGEDLAGALARLLGEVLEADRGRAELEYELYLAALRRPALRPVAAEWCE  126

Query  134  GLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVAD-----GPE  187
             + A L        A A+    DG +L  L+TGTP     + + + R+VA      GPE
Sbjct  127  AVTAALAEHTDPLTARALVAVMDGISLQVLLTGTPYDGAYVRELLRRVVAGADGRRGPE  185


>gi|294628707|ref|ZP_06707267.1| transcriptional regulatory protein [Streptomyces sp. e14]
 gi|292832040|gb|EFF90389.1| transcriptional regulatory protein [Streptomyces sp. e14]
Length=179

 Score =  103 bits (258),  Expect = 1e-20, Method: Compositional matrix adjust.
 Identities = 70/165 (43%), Positives = 91/165 (56%), Gaps = 1/165 (0%)

Query  19   IVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASADLLA  78
            I++AA RV+ R G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL  +      L+A
Sbjct  14   IIDAAIRVVRRAGIAGLSHRTVAAEADVPLGSTTYHFATLDELMVAALRQSGEGFCRLVA  73

Query  79   QWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQRLARLWPDGLLA  137
                  D   DLA  LA     +LA       L  ELY+AA  RP L+ +A  W D L A
Sbjct  74   AREGLTDPGGDLAGELAAALGEWLAAGRAGAELEYELYLAALRRPALRPVAAGWADDLAA  133

Query  138  LLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            LL PR     A A+    DG  L+ L+TG     +   +A+AR++
Sbjct  134  LLAPRTDPLTARALVALMDGICLNVLLTGGSYDEEYAREALARMI  178


>gi|302550604|ref|ZP_07302946.1| TetR family transcriptional regulator [Streptomyces viridochromogenes 
DSM 40736]
 gi|302468222|gb|EFL31315.1| TetR family transcriptional regulator [Streptomyces viridochromogenes 
DSM 40736]
Length=183

 Score =  102 bits (255),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 73/181 (41%), Positives = 95/181 (53%), Gaps = 2/181 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA RV+  +G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  4    RRHDPE-RRQRIIDAAIRVVGAKGIAGLSHRSAAAEADVPLGSTTYHFKTLDELLVAALR  62

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLA-DQDRYRTLNELYMAAAHRPELQR  126
             A    A ++A      D   DLAA LA     +LA D+       ELY+AA  RP L+ 
Sbjct  63   QANEGFAKVIASRGGLEDPRTDLAAELAGSMGEWLAGDRTGVELEYELYLAALRRPALRP  122

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADGP  186
            +A  W + +   L  R     A A+    DG  L  L+TG P       + + R+VA   
Sbjct  123  VADEWAEQVAESLSRRTDPVTARALVAVVDGICLQVLLTGVPYDESYAREVLGRIVAGAR  182

Query  187  E  187
            E
Sbjct  183  E  183


>gi|290961362|ref|YP_003492544.1| repressor [Streptomyces scabiei 87.22]
 gi|260650888|emb|CBG74005.1| putative repressor [Streptomyces scabiei 87.22]
Length=178

 Score =  100 bits (250),  Expect = 9e-20, Method: Compositional matrix adjust.
 Identities = 71/176 (41%), Positives = 93/176 (53%), Gaps = 2/176 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA RV+A +G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  3    RRYDPE-RRQRIIDAAIRVVAERGIAGLSHRSAAAEADVPLGSTTYHFKTLDDLMVAALR  61

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRPELQR  126
             A    A  +A   +  D   DLAA LA L   +   D+       ELY+AA  RP L+ 
Sbjct  62   QANERFAKSVAAREALRDPGTDLAAELAALGGEWFTGDRTGLEVEYELYLAALRRPALRP  121

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            +A  W       L  R     A A+    DG  L  L+TG P   +   + +AR++
Sbjct  122  VADEWGRAFADCLADRTDPVTARALVALVDGICLQVLLTGAPYDEEYAREVLARVI  177


>gi|29832878|ref|NP_827512.1| TetR family transcriptional regulator [Streptomyces avermitilis 
MA-4680]
 gi|29609999|dbj|BAC74047.1| putative TetR-family transcriptional regulator [Streptomyces 
avermitilis MA-4680]
Length=178

 Score = 99.4 bits (246),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 71/170 (42%), Positives = 94/170 (56%), Gaps = 3/170 (1%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I++AA RV+  +G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL  A    A
Sbjct  9    RRQRIIDAAIRVVGDKGIAGLSHRSVAAEADVPLGSTTYHFKTLDDLMVAALRQANEGFA  68

Query  75   DLLAQWRSDLDKDR-DLAATLARLTTVYLA-DQDRYRTLNELYMAAAHRPELQRLARLWP  132
             ++A  R  L+  R DLA  +A L   +LA D+       ELY+AA  RP L+ +A    
Sbjct  69   KVVAA-RGHLEDPRADLAGDIAALIGDWLAGDRTGVELEYELYLAALRRPALRPVAAECI  127

Query  133  DGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            DG    +  R     A A+    DG  L  L+TG P       + +ARL+
Sbjct  128  DGFAEAVARRTDPVTARALVALVDGICLQVLLTGAPYDEAYARELLARLI  177


>gi|320011459|gb|ADW06309.1| transcriptional regulator, TetR family [Streptomyces flavogriseus 
ATCC 33331]
Length=205

 Score = 98.2 bits (243),  Expect = 6e-19, Method: Compositional matrix adjust.
 Identities = 71/180 (40%), Positives = 92/180 (52%), Gaps = 2/180 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RR+ I+EAA RV+  QG+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  3    RRHDPE-RRERIIEAAIRVVGAQGIAGLSHRSVAAEADVPLGSTTYHFASLDELLVAALR  61

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQR  126
                  A ++ +     D    LA  L RL   + +       L  ELY+AA  RP L+ 
Sbjct  62   RCNENFARMVREGDGLADPAVPLADALTRLLGEWFSGGRGPMELEYELYLAALRRPVLRP  121

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADGP  186
            +A  W D L+  +  R     A A+T   DG  L  L+TG         + +ARL    P
Sbjct  122  VAGEWADALVEPIAHRTDPATARALTALLDGICLQVLLTGGEFDPVYTREMLARLAEGEP  181


>gi|302546314|ref|ZP_07298656.1| TetR family transcriptional regulator [Streptomyces hygroscopicus 
ATCC 53653]
 gi|302463932|gb|EFL27025.1| TetR family transcriptional regulator [Streptomyces himastatinicus 
ATCC 53653]
Length=180

 Score = 97.4 bits (241),  Expect = 1e-18, Method: Compositional matrix adjust.
 Identities = 72/176 (41%), Positives = 94/176 (54%), Gaps = 3/176 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA  V+  +G+GGLSHR VAAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  4    RRYDPE-RRQRIIDAAIAVVGERGIGGLSHRAVAAEADVPLGSTTYHFATLDDLLVAALD  62

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRPELQR  126
                     + +W  D   D  LA  +A L  + L  D+ R     ELY+AA  R  ++ 
Sbjct  63   QVNAEWLADMERWERDAPPDAPLADGMAGLMEMLLTGDRKRLELEYELYLAALRRTSVRP  122

Query  127  LARLWPDGLLALLEPRIGR-RAANAVTVFFDGATLHALITGTPLSTDELTDAIARL  181
            LA  + D +  LL  R G    A A+   FDG  L  L+TG     +E   A AR+
Sbjct  123  LAAAFLDRMTELLVRRTGDVDVARAINALFDGMLLQVLLTGREFDREEARAAFARV  178


>gi|294632913|ref|ZP_06711472.1| conserved hypothetical protein [Streptomyces sp. e14]
 gi|292830694|gb|EFF89044.1| conserved hypothetical protein [Streptomyces sp. e14]
Length=192

 Score = 96.7 bits (239),  Expect = 2e-18, Method: Compositional matrix adjust.
 Identities = 72/165 (44%), Positives = 89/165 (54%), Gaps = 0/165 (0%)

Query  19   IVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASADLLA  78
            IVEAA  ++   GLGGL+HR VA  A V +GSTT+YF  LD LREAAL H A+     LA
Sbjct  16   IVEAAAALVIEVGLGGLTHRMVANRAQVALGSTTHYFATLDDLREAALRHLADQVDSGLA  75

Query  79   QWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRPELQRLARLWPDGLLAL  138
            + +  LD+     A LA     YLAD    R    L  AA   P  + LA    D L+AL
Sbjct  76   EVKRSLDEHGADPAVLAEALFAYLADTHLVRADTCLLSAAVVDPHFRSLALQTFDRLVAL  135

Query  139  LEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVA  183
            +   +G R A A+ VF  GA  HA +   PL    LT+ I RL+A
Sbjct  136  MSAYVGVREATAIAVFAQGAAAHAALHEEPLDVASLTEVITRLLA  180


>gi|326780054|ref|ZP_08239319.1| transcriptional regulator, TetR family [Streptomyces cf. griseus 
XylebKG-1]
 gi|326660387|gb|EGE45233.1| transcriptional regulator, TetR family [Streptomyces griseus 
XylebKG-1]
Length=198

 Score = 95.9 bits (237),  Expect = 3e-18, Method: Compositional matrix adjust.
 Identities = 74/193 (39%), Positives = 93/193 (49%), Gaps = 19/193 (9%)

Query  11   DPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREA------  64
            DP GRR+ IV+AA RVIA  G+ GLSHR VAAEA+VP+GSTTY+F  LD L  A      
Sbjct  6    DP-GRRERIVDAALRVIAADGIAGLSHRTVAAEADVPLGSTTYHFGSLDELLVAALRRYN  64

Query  65   -----------ALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-  112
                       ALA    AS        +  D    LA  L RL   + A +     L  
Sbjct  65   DNFVRELRGSQALAGPTGASGPTGPTGPAGPDGPAGLAEELTRLLGRWFAGERGAIELEY  124

Query  113  ELYMAAAHRPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTD  172
            ELY+AA  RP L+ +A  W +  + LL  R  R  A A+    DG  L  L+TG      
Sbjct  125  ELYLAALRRPVLRPVAAEWTEEAIELLSRRTDRETARALVALMDGVCLQVLLTGGAFDAP  184

Query  173  ELTDAIARLVADG  185
               + + R+V  G
Sbjct  185  RTREMLGRIVDGG  197


>gi|344998942|ref|YP_004801796.1| TetR family transcriptional regulator [Streptomyces sp. SirexAA-E]
 gi|344314568|gb|AEN09256.1| transcriptional regulator, TetR family [Streptomyces sp. SirexAA-E]
Length=183

 Score = 94.0 bits (232),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 70/179 (40%), Positives = 92/179 (52%), Gaps = 2/179 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RR  I+EAA R++A +G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  3    RRYDPE-RRDRIIEAAIRIVADRGIAGLSHRTVAAEADVPLGSTTYHFASLDELLVAALR  61

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQR  126
                     + +     D + DLA  L RL   + A +     L  ELY+AA  RP L+ 
Sbjct  62   RCNENFVRTVRESARLADPEADLADELTRLLGEWFAGERGAIELEYELYLAALRRPALRP  121

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADG  185
            +A  W D    LL  R     A A+    DG +L  L+ G         + +AR+V  G
Sbjct  122  VAAEWADEAGELLARRTDPATARALVALLDGISLQVLLAGGDFDAAYTREMLARIVEGG  180


>gi|328881595|emb|CCA54834.1| Transcriptional regulator, TetR family [Streptomyces venezuelae 
ATCC 10712]
Length=182

 Score = 93.6 bits (231),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 75/164 (46%), Positives = 95/164 (58%), Gaps = 4/164 (2%)

Query  8    RPR--DPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAA  65
            RPR  DPA RR+ IV+AA RV AR G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AA
Sbjct  3    RPRRHDPA-RRERIVDAALRVAARSGIAGLSHRTVAAEADVPLGSTTYHFASLDELLVAA  61

Query  66   LAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRPEL  124
            L  A      LL +  +      DLAA LARL   +L  ++ R     ELY+AA  RP L
Sbjct  62   LRKANEGFDRLLRENSALTAPGTDLAAALARLLGEWLGGERARVELEYELYLAALRRPAL  121

Query  125  QRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTP  168
            + +A  W + ++A L P      A A+    DG  L +L+T  P
Sbjct  122  RPVAVEWAETVVAALSPHTDPVTARALVALMDGICLQSLLTDEP  165


>gi|262201944|ref|YP_003273152.1| TetR family transcriptional regulator [Gordonia bronchialis DSM 
43247]
 gi|262085291|gb|ACY21259.1| regulatory protein TetR [Gordonia bronchialis DSM 43247]
Length=196

 Score = 91.3 bits (225),  Expect = 7e-17, Method: Compositional matrix adjust.
 Identities = 63/167 (38%), Positives = 83/167 (50%), Gaps = 0/167 (0%)

Query  19   IVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASADLLA  78
            I++AA  +I   G  GL+HR VA  A VP+GSTT YF  LD LREA L H A+     + 
Sbjct  22   IIDAAAELIVELGSAGLTHRLVADRAGVPLGSTTQYFTSLDELREAGLHHLADEIDGEVR  81

Query  79   QWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRPELQRLARLWPDGLLAL  138
             +   L +    A     +   YL D    R    L  AA   P L  LA   P  ++ L
Sbjct  82   DFAGVLRERGASADVFGEMLHAYLCDIRLVRADLALLNAAFVDPALGPLALRLPTAVIYL  141

Query  139  LEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADG  185
            L P IG + A AV  + DG  +H ++ GT  +  EL+DA+A L   G
Sbjct  142  LIPHIGEQRARAVAAYVDGVAMHTVLRGTTPTIAELSDALAALTNSG  188


>gi|182439398|ref|YP_001827117.1| TetR family transcriptional regulator [Streptomyces griseus subsp. 
griseus NBRC 13350]
 gi|178467914|dbj|BAG22434.1| putative TetR-family transcriptional regulator [Streptomyces 
griseus subsp. griseus NBRC 13350]
Length=198

 Score = 90.9 bits (224),  Expect = 1e-16, Method: Compositional matrix adjust.
 Identities = 72/193 (38%), Positives = 90/193 (47%), Gaps = 19/193 (9%)

Query  11   DPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL----  66
            DP GRR+ IV+AA RVIA  G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL    
Sbjct  6    DP-GRRERIVDAALRVIAADGIAGLSHRTVAAEADVPLGSTTYHFGSLDELLVAALRRYN  64

Query  67   -------------AHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-  112
                         A     S                LA  L RL   + A +     L  
Sbjct  65   DNFVRELRGSQALAGPGGVSGPTGPAGPDGPAGPAGLAEELTRLLGRWFAGERGAIELEY  124

Query  113  ELYMAAAHRPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTD  172
            ELY+AA  RP L+ +A  W +  + LL  R  R  A A+    DG  L  L+TG      
Sbjct  125  ELYLAALRRPVLRPVAAEWTEEAVELLSRRTDRETARALVALMDGVCLQVLLTGGAFDAP  184

Query  173  ELTDAIARLVADG  185
               + + R+V  G
Sbjct  185  RTREMLGRIVDGG  197


>gi|254384161|ref|ZP_04999505.1| ebrA repressor [Streptomyces sp. Mg1]
 gi|194343050|gb|EDX24016.1| ebrA repressor [Streptomyces sp. Mg1]
Length=199

 Score = 88.2 bits (217),  Expect = 6e-16, Method: Compositional matrix adjust.
 Identities = 65/169 (39%), Positives = 89/169 (53%), Gaps = 4/169 (2%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I++AA RV+  +G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL  A  A  
Sbjct  31   RRQRIIDAAIRVVGAKGIAGLSHRSVAAEADVPLGSTTYHFKTLDELLVAALRQANQAFT  90

Query  75   DLLAQWRSDLDKDRDLAAT-LARLTTVYLADQDRYRTLNELYMAAAHRPELQRLARLWPD  133
              L    +      D+A +    L  +  AD+ R     ELY+AA  RP L+ +A  W +
Sbjct  91   VTLPATPAPAG---DVAGSLARLLGRLLAADRGRVELEYELYLAALRRPALRPVAAEWYE  147

Query  134  GLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
             +   L P      A A+    DG  L  L+T TP       + +AR++
Sbjct  148  AVATALAPWTDPVTARALVAVMDGICLQVLLTDTPYDERYAREVLARVL  196


>gi|257057139|ref|YP_003134971.1| hypothetical protein Svir_31710 [Saccharomonospora viridis DSM 
43017]
 gi|256587011|gb|ACU98144.1| uncharacterized conserved protein [Saccharomonospora viridis 
DSM 43017]
Length=189

 Score = 88.2 bits (217),  Expect = 6e-16, Method: Compositional matrix adjust.
 Identities = 63/164 (39%), Positives = 81/164 (50%), Gaps = 4/164 (2%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            R P DP  RR  I  AA  VIA +G+  L+HR VAAEA VP+GSTTY+F  LD L   AL
Sbjct  13   RGPNDP-DRRNRIARAAITVIAERGINALTHRMVAAEAGVPLGSTTYHFATLDDLVAVAL  71

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNE--LYMAAAHRPEL  124
              AA  + D L +W + L +D DL   L  L    +  Q R  T+ E  LY  A  RP L
Sbjct  72   DEAARRNIDALREWNAALPEDVDLVTALTDLVLDSVTKQ-RADTIAEYNLYALALQRPHL  130

Query  125  QRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTP  168
            +R A  W + L  +   R        +     G  +  ++  TP
Sbjct  131  RRAAVAWDNALADVFSTRTDPLTGRMIATLTCGLMMQTVLGETP  174


>gi|269219739|ref|ZP_06163593.1| putative transcriptional regulatory protein [Actinomyces sp. 
oral taxon 848 str. F0332]
 gi|269210981|gb|EEZ77321.1| putative transcriptional regulatory protein [Actinomyces sp. 
oral taxon 848 str. F0332]
Length=248

 Score = 87.8 bits (216),  Expect = 8e-16, Method: Compositional matrix adjust.
 Identities = 65/182 (36%), Positives = 93/182 (52%), Gaps = 7/182 (3%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREA---  64
            R RDP  RR+AI+ AA  VI  +G   L+HR VAA A V +GSTT YF+ ++ LRE    
Sbjct  58   RKRDPEARRRAILNAAIDVIVEKGAAALTHRAVAARAGVSLGSTTKYFSSIEDLRENAMD  117

Query  65   ALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRPEL  124
            AL    +A  D    + S+L+   D+ +    L   YL D  + R    L  A A    L
Sbjct  118  ALVREMDAGVD---AFESELEACDDVESYCIGLAYEYLRDVRQVRADVALLNAGARDDGL  174

Query  125  QRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVAD  184
            + +A   PD L+A L P  G   A A+ +  +GA +H+ +  TP+   E+ + I R +  
Sbjct  175  REIALRNPDRLIAALAPHFGAERAMALELCLEGAVVHSALRSTPIDK-EVIERIFRGIIS  233

Query  185  GP  186
             P
Sbjct  234  AP  235


>gi|296137890|ref|YP_003645133.1| TetR family transcriptional regulator [Tsukamurella paurometabola 
DSM 20162]
 gi|296026024|gb|ADG76794.1| transcriptional regulator, TetR family [Tsukamurella paurometabola 
DSM 20162]
Length=192

 Score = 87.4 bits (215),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 64/155 (42%), Positives = 85/155 (55%), Gaps = 8/155 (5%)

Query  19   IVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASADLLA  78
            IV+AA  ++   G   L+HR+VAA A VP+GSTT YF  LD LREAAL +      D   
Sbjct  17   IVDAAAALVLESGADALTHRKVAARAGVPLGSTTQYFATLDDLREAALRNL----MDEAE  72

Query  79   QWRSDLDKD--RDLAATLARLTTV--YLADQDRYRTLNELYMAAAHRPELQRLARLWPDG  134
            QW +DL+ +  RD A++ A    +  YL+D    R    +  AAA  P+++ LAR W   
Sbjct  73   QWLADLEAEFVRDGASSAAYTGALHRYLSDPQLVRGDFAMTCAAASSPDMEELARHWTAR  132

Query  135  LLALLEPRIGRRAANAVTVFFDGATLHALITGTPL  169
            L+  L   I    A AV  F DGAT+ A+I   PL
Sbjct  133  LVEALARYIPVENARAVATFSDGATMDAVIAERPL  167


>gi|326383954|ref|ZP_08205638.1| regulatory protein TetR [Gordonia neofelifaecis NRRL B-59395]
 gi|326197413|gb|EGD54603.1| regulatory protein TetR [Gordonia neofelifaecis NRRL B-59395]
Length=183

 Score = 86.7 bits (213),  Expect = 2e-15, Method: Compositional matrix adjust.
 Identities = 65/174 (38%), Positives = 83/174 (48%), Gaps = 0/174 (0%)

Query  10   RDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHA  69
            RDP  RR AIVEAA  ++   G   L+HRRVA  A VP+GSTT YF+ +D LR  ALA  
Sbjct  4    RDPEARRAAIVEAAADLVVELGPERLTHRRVAERAGVPLGSTTQYFSSIDDLRTQALARL  63

Query  70   ANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRPELQRLAR  129
            A    D L   R  L         L      YL +         L  AAA   EL+ LA 
Sbjct  64   ATEIDDDLDAVRQSLADSGGSVEVLVEQMHDYLTNSRNVSADVSLMSAAAFDAELRTLAL  123

Query  130  LWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVA  183
             W   L+ +L   +G   A A+ +  DG T+HA +   P+S   L   +A  +A
Sbjct  124  RWQHNLVDILTGYVGPDNALALAMLADGVTVHAALHDAPVSKQFLHTLVAPFMA  177


>gi|333920137|ref|YP_004493718.1| hypothetical protein AS9A_2471 [Amycolicicoccus subflavus DQS3-9A1]
 gi|333482358|gb|AEF40918.1| hypothetical protein AS9A_2471 [Amycolicicoccus subflavus DQS3-9A1]
Length=193

 Score = 85.9 bits (211),  Expect = 3e-15, Method: Compositional matrix adjust.
 Identities = 66/161 (41%), Positives = 84/161 (53%), Gaps = 4/161 (2%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            R P DP  RR  IVEAA  V+  QG+  L+HRRVAA A VP+GSTTY+F  LD L  AAL
Sbjct  10   RGPTDP-DRRDRIVEAAIVVLTEQGVSALTHRRVAAAAEVPLGSTTYHFATLDDLLAAAL  68

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNE--LYMAAAHRPEL  124
              AA  S   L  W   LD D D+A  L+    V    + R  T+ E  LY  A HRP L
Sbjct  69   TKAAERSVAALRAWEESLDPDADIAHALSEF-VVRSVSETRSDTMAEYNLYALALHRPHL  127

Query  125  QRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALIT  165
            +  A  W + L  +L  R    A + + V   G  +  +++
Sbjct  128  RAAAVAWDNALAEVLSRRTDPVAGHMLGVLLCGLLMQVVLS  168


>gi|295839578|ref|ZP_06826511.1| TetR family transcriptional regulator [Streptomyces sp. SPB74]
 gi|295827546|gb|EDY43772.2| TetR family transcriptional regulator [Streptomyces sp. SPB74]
Length=189

 Score = 84.3 bits (207),  Expect = 8e-15, Method: Compositional matrix adjust.
 Identities = 71/177 (41%), Positives = 90/177 (51%), Gaps = 2/177 (1%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I++AA RV  R G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL  A    A
Sbjct  11   RRQRIIDAAIRVTGRSGIAGLSHRTAAAEADVPLGSTTYHFATLDDLLVAALRQANENFA  70

Query  75   DLLAQWRSDLDKDRDLAATLARLTTVYL-ADQDRYRTLNELYMAAAHRPELQRLARLWPD  133
             L+    +       LAA LA     +L AD+       ELY+AA  RP L+ +A  W  
Sbjct  71   RLVRDRGALRAPPGGLAAALADAMGAWLAADRANAELEYELYLAALRRPPLRPVAAEWSR  130

Query  134  GLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV-ADGPEQR  189
             L   L  R     A AV    DG  L  L+T +P       + + R++  DGP  R
Sbjct  131  ALEEPLTARTDPATARAVVALMDGLCLQVLLTDSPYDEAYAREMLGRVLREDGPPAR  187


>gi|318056391|ref|ZP_07975114.1| hypothetical protein SSA3_00505 [Streptomyces sp. SA3_actG]
 gi|318075708|ref|ZP_07983040.1| hypothetical protein SSA3_03097 [Streptomyces sp. SA3_actF]
Length=181

 Score = 83.2 bits (204),  Expect = 2e-14, Method: Compositional matrix adjust.
 Identities = 69/176 (40%), Positives = 90/176 (52%), Gaps = 2/176 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA RV+ R G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  5    RRYDP-DRRQRIIDAAIRVVGRSGIAGLSHRSAAAEADVPLGSTTYHFATLDDLLVAALR  63

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQR  126
             A    A L+            LAA LA     +LA    +  L  ELY+AA  +P L+ 
Sbjct  64   QANENFARLVRDLGVLRAPPAGLAAALAGAMGAWLAADRAHAELEYELYLAAVRKPVLRP  123

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            +A  W   L   L  R     A AV    DG  L  L+T +P   +   + + R++
Sbjct  124  VAAEWSRALEEPLAARTDPATARAVVALMDGLCLQVLLTDSPYDEEYAREMLGRVL  179


>gi|311280270|ref|YP_003942501.1| transcriptional regulator, TetR family [Enterobacter cloacae 
SCF1]
 gi|308749465|gb|ADO49217.1| transcriptional regulator, TetR family [Enterobacter cloacae 
SCF1]
Length=188

 Score = 83.2 bits (204),  Expect = 2e-14, Method: Compositional matrix adjust.
 Identities = 52/183 (29%), Positives = 88/183 (49%), Gaps = 2/183 (1%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            RRP DP  RR+ I++A    IAR G+  ++HR++A  A+VP+GS TYYF+ +DAL E A 
Sbjct  3    RRPNDPL-RRERIIQATLDTIARHGIQAVTHRKIAQCADVPLGSMTYYFSGIDALLEEAF  61

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLTT-VYLADQDRYRTLNELYMAAAHRPELQ  125
                   +     + +D+    D    + RL +   +        + ++Y   + +P L+
Sbjct  62   TSFTAQMSRQYQAFFTDVLTPDDACDAITRLISGAEVTTARNMELMYQMYAFTSCKPALK  121

Query  126  RLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADG  185
             + + W       LE       A A+  F +G TLH +    PL  DE+   + R+  + 
Sbjct  122  GVMQDWMQRSQQTLERWFDAPTARALDAFIEGMTLHFVTDRAPLGRDEIRQMVGRIAGEQ  181

Query  186  PEQ  188
             ++
Sbjct  182  KQK  184


>gi|302518364|ref|ZP_07270706.1| ebrA repressor [Streptomyces sp. SPB78]
 gi|302427259|gb|EFK99074.1| ebrA repressor [Streptomyces sp. SPB78]
Length=181

 Score = 82.8 bits (203),  Expect = 3e-14, Method: Compositional matrix adjust.
 Identities = 69/176 (40%), Positives = 90/176 (52%), Gaps = 2/176 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA RV+ R G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  5    RRYDP-DRRQRIIDAAIRVVGRAGIAGLSHRSAAAEADVPLGSTTYHFATLDDLLVAALR  63

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQR  126
             A    A L+            LAA LA     +LA    +  L  ELY+AA  +P L+ 
Sbjct  64   QANENFARLVRDLGVLRAPPAGLAAALAGAMGAWLAADRAHAELEYELYLAAVRKPVLRP  123

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            +A  W   L   L  R     A AV    DG  L  L+T +P   +   + + R++
Sbjct  124  VAAEWSRALEEPLAARTDPATARAVVALMDGLCLQVLLTDSPYDEEYAREMLGRVL  179


>gi|333027966|ref|ZP_08456030.1| hypothetical protein STTU_5470 [Streptomyces sp. Tu6071]
 gi|332747818|gb|EGJ78259.1| hypothetical protein STTU_5470 [Streptomyces sp. Tu6071]
Length=181

 Score = 82.0 bits (201),  Expect = 4e-14, Method: Compositional matrix adjust.
 Identities = 68/176 (39%), Positives = 89/176 (51%), Gaps = 2/176 (1%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RRQ I++AA RV+ R G+ GLSHR  AAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  5    RRYDP-DRRQRIIDAAIRVVGRSGIAGLSHRSAAAEADVPLGSTTYHFATLDDLLVAALR  63

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLN-ELYMAAAHRPELQR  126
                  A L+            LAA LA     +LA    +  L  ELY+AA  +P L+ 
Sbjct  64   QVNENFARLVRDLGVLRAPPAGLAAALAGAMGAWLAADRAHAELEYELYLAAVRKPVLRP  123

Query  127  LARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
            +A  W   L   L  R     A AV    DG  L  L+T +P   +   + + R++
Sbjct  124  VAAEWSRALEEPLAARTDPATARAVVALMDGLCLQVLLTDSPYDEEYAREMLGRVL  179


>gi|260597241|ref|YP_003209812.1| HTH-type transcriptional regulator YbjK [Cronobacter turicensis 
z3032]
 gi|260216418|emb|CBA29506.1| Uncharacterized HTH-type transcriptional regulator ybjK [Cronobacter 
turicensis z3032]
Length=181

 Score = 82.0 bits (201),  Expect = 5e-14, Method: Compositional matrix adjust.
 Identities = 58/184 (32%), Positives = 93/184 (51%), Gaps = 12/184 (6%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RR+ I+EA    IA  G   ++HR++A EA VP+GS TYYF  L+AL   A  
Sbjct  4    RQNDPQ-RRERILEATLACIAAHGFHHITHRKIALEAGVPLGSVTYYFTTLEALLAEAFT  62

Query  68   HAANASAD----LLAQWRSDLDKDRDLAATL--ARLTTVYLADQDRYRTLNELYMAAAHR  121
              A + +     L+AQ +S  +    L A +  A++TT      +    + +LY  A+ +
Sbjct  63   RFAESMSCQYQALMAQAQSREEACEALTALICGAQVTT-----PENMELMYQLYAYASRQ  117

Query  122  PELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARL  181
            P+L+ + + W       LE       A A+  F +G TLH ++   PL+ + +   + R+
Sbjct  118  PQLKIIMQDWMRRSQQTLETWFDPATARALDAFVEGMTLHYVVDREPLNRETIRSMVGRI  177

Query  182  VADG  185
            V +G
Sbjct  178  VGEG  181


>gi|157146502|ref|YP_001453820.1| hypothetical protein CKO_02263 [Citrobacter koseri ATCC BAA-895]
 gi|157083707|gb|ABV13385.1| hypothetical protein CKO_02263 [Citrobacter koseri ATCC BAA-895]
Length=185

 Score = 81.6 bits (200),  Expect = 6e-14, Method: Compositional matrix adjust.
 Identities = 51/176 (29%), Positives = 85/176 (49%), Gaps = 2/176 (1%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            RR  DP  RR  IV+A +  I   G+ G++HR++AA A VP+GS TYYF+ +D L   AL
Sbjct  7    RRANDPL-RRDKIVQATQEAIITHGIHGVTHRKIAAIAQVPLGSMTYYFSGIDELLIEAL  65

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQ-DRYRTLNELYMAAAHRPELQ  125
            +      +     + +D+   +D    +  +    L    D    + +LY  A+ +P L+
Sbjct  66   SRFTETMSHQFQLFFADVTNVQDACHAITDMIYSSLVTTPDNMELMYQLYAFASRKPALK  125

Query  126  RLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARL  181
             + + W       LE       A A+  F +G TLH +    PL+ +++   + R+
Sbjct  126  TVMQNWMQRSQQTLEQWFEPVTARALDAFIEGMTLHFVTDRAPLTREDILVMVKRI  181


>gi|271969071|ref|YP_003343267.1| TetR family transcriptional regulator [Streptosporangium roseum 
DSM 43021]
 gi|270512246|gb|ACZ90524.1| transcriptional regulator, TetR family [Streptosporangium roseum 
DSM 43021]
Length=240

 Score = 80.9 bits (198),  Expect = 9e-14, Method: Compositional matrix adjust.
 Identities = 65/186 (35%), Positives = 89/186 (48%), Gaps = 12/186 (6%)

Query  7    RRPR--DPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREA  64
            RRPR  DP  RR  I++    VIA  GL G  HR VA  A+VP+GS TY+F  LD L E 
Sbjct  59   RRPRRHDP-NRRDRIIDVTIDVIAEHGLAGTGHRSVAEAADVPLGSMTYHFASLDELVEL  117

Query  65   ALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYR----TLNELYMAAAH  120
            A +   +  AD      +   +  DLAA    +T V + D  R R       ELY+ AA 
Sbjct  118  AFSRYVSVLADRFDARLAAAPESGDLAAI---VTDVIMVDFLRARRDLVLAYELYLGAAR  174

Query  121  RPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIAR  180
             P L+ + R W       LE       A  +    +G  LH  +   P++ +E+  A+AR
Sbjct  175  NPALREVTRTWMRRSRRALERLTDPATARVLDALLEGLVLHNFLATDPMTREEVHQAVAR  234

Query  181  LVADGP  186
            ++  GP
Sbjct  235  VI--GP  238


>gi|146310995|ref|YP_001176069.1| TetR family transcriptional regulator [Enterobacter sp. 638]
 gi|145317871|gb|ABP60018.1| transcriptional regulator, TetR family [Enterobacter sp. 638]
Length=182

 Score = 80.5 bits (197),  Expect = 1e-13, Method: Compositional matrix adjust.
 Identities = 51/183 (28%), Positives = 86/183 (47%), Gaps = 8/183 (4%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            RRP DP  RR+ I++A    IA  G+  ++HR++A  A VP+GS TYYF  +D+L E A 
Sbjct  3    RRPNDPL-RRERILQATLETIAEHGIDAVTHRKIATCAGVPLGSMTYYFEGMDSLLEEAF  61

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQ----DRYRTLNELYMAAAHRP  122
                  + D+  Q+                +TT+  + +         + +LY   + +P
Sbjct  62   ---TRFTCDMSQQYCDFFAGVTGPEMACESITTLIHSSEVTTPHNMELMYQLYALMSRKP  118

Query  123  ELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
             L+++ + W     + LE       A A+  F +G TLH +    PLS D++   + R+ 
Sbjct  119  ALKKVMQDWMQTSQSTLEQWFDPVTARALDAFIEGMTLHFVTDRQPLSRDDIRRMVGRIA  178

Query  183  ADG  185
             + 
Sbjct  179  GEN  181


>gi|239986856|ref|ZP_04707520.1| TetR family transcriptional regulator [Streptomyces roseosporus 
NRRL 11379]
 gi|291443808|ref|ZP_06583198.1| ebrA repressor [Streptomyces roseosporus NRRL 15998]
 gi|291346755|gb|EFE73659.1| ebrA repressor [Streptomyces roseosporus NRRL 15998]
Length=200

 Score = 80.5 bits (197),  Expect = 1e-13, Method: Compositional matrix adjust.
 Identities = 73/197 (38%), Positives = 93/197 (48%), Gaps = 20/197 (10%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RR  I++AA  VIA  G+ GLSHR VAAEA+VP+GSTTY+F  LD L  AAL 
Sbjct  3    RRYDPE-RRTRIIDAALTVIAADGMAGLSHRTVAAEADVPLGSTTYHFASLDELLVAALR  61

Query  68   HA------ANASADLLAQWRSDLD------------KDRDLAATLARLTTVYLADQDRYR  109
                    A  S+ L A+   +              +   LA  L RL   + A +    
Sbjct  62   RCNENFVQALRSSGLFAEEAEEGGAGRGEGDAGQGAEGAGLAEELTRLLDRWFAGERGAI  121

Query  110  TLN-ELYMAAAHRPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTP  168
             L  ELY+AA  RP L+ +A  W    +ALL  R     A A+    DG  L  L+TG  
Sbjct  122  ELEYELYLAALRRPALRPVAAEWTTEAVALLSRRTDPETARALVALMDGVCLQVLLTGGT  181

Query  169  LSTDELTDAIARLVADG  185
                     + R+VA G
Sbjct  182  FDAAYTRVMLERIVAGG  198


>gi|134103635|ref|YP_001109296.1| putative DeoR-type transcriptional regulator [Saccharopolyspora 
erythraea NRRL 2338]
 gi|291004829|ref|ZP_06562802.1| putative DeoR-type transcriptional regulator [Saccharopolyspora 
erythraea NRRL 2338]
 gi|133916258|emb|CAM06371.1| putative DeoR-type transcriptional regulator [Saccharopolyspora 
erythraea NRRL 2338]
Length=201

 Score = 80.5 bits (197),  Expect = 1e-13, Method: Compositional matrix adjust.
 Identities = 60/179 (34%), Positives = 90/179 (51%), Gaps = 7/179 (3%)

Query  19   IVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASADLLA  78
            IV+A  RV+AR G+ G+SHR +A EA VP  S  YYF+ +D L  A L  +       + 
Sbjct  22   IVDATLRVVARDGIAGVSHRNIAREAGVPAASVGYYFDSIDDLLVATLLDSVEVLIAEID  81

Query  79   QWRSDLDKDRDLAATLARLTTVYLADQDRYRTL--NELYMAAAHRPELQRLARLWPDGLL  136
            +  S++  D      +AR+    + D+ R RTL   ELY+ AA RP L+  AR W +   
Sbjct  82   RMTSEVGSDEQWPGVVARMLA-RMIDEHRERTLAEYELYLLAARRPALRPAARRWIEVAT  140

Query  137  ALLEPRIGRRAANAVTVFF---DGATLHALITGTPLSTDELTDAIARLVADGPEQREVG  192
              +    G    +A+  FF   DG  L AL+   P + +EL  ++  ++  G   R +G
Sbjct  141  GYVNGGEGGD-PHAMRAFFAAIDGLVLQALVADEPPTAEELEASLRYVMQPGSYLRSLG  198


>gi|170768984|ref|ZP_02903437.1| transcriptional regulator, TetR family [Escherichia albertii 
TW07627]
 gi|170122056|gb|EDS90987.1| transcriptional regulator, TetR family [Escherichia albertii 
TW07627]
Length=191

 Score = 79.3 bits (194),  Expect = 3e-13, Method: Compositional matrix adjust.
 Identities = 49/179 (28%), Positives = 86/179 (49%), Gaps = 8/179 (4%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            RR  DP  RR+ I+ A    +   G+  ++HR++A  A VP+GS TYYF+ +D L   A 
Sbjct  2    RRANDPQ-RREKIIRATLEAVKLYGIHAVTHRKIAVLAQVPLGSMTYYFSGIDELLLEAF  60

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQ----DRYRTLNELYMAAAHRP  122
            +      +    Q+++  D   D ++    +T +  + Q    +    + +LY  A+ +P
Sbjct  61   SRFTQTMS---LQYQTFFDDVSDASSACQAITEMIYSSQVATPNNMELMYQLYALASRKP  117

Query  123  ELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARL  181
            +L+ + + W       LE       A A+  F +G TLH +    PLS +E+   + R+
Sbjct  118  QLKTVMQNWMQRSQQTLEQWFEPGTARALDAFIEGMTLHFVTDCKPLSREEILKMVERV  176


>gi|297560633|ref|YP_003679607.1| TetR family transcriptional regulator [Nocardiopsis dassonvillei 
subsp. dassonvillei DSM 43111]
 gi|296845081|gb|ADH67101.1| transcriptional regulator, TetR family [Nocardiopsis dassonvillei 
subsp. dassonvillei DSM 43111]
Length=184

 Score = 79.3 bits (194),  Expect = 3e-13, Method: Compositional matrix adjust.
 Identities = 60/172 (35%), Positives = 83/172 (49%), Gaps = 7/172 (4%)

Query  5    SDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREA  64
            SD R      RRQA++EA  RVI R G+ G+SHR V+ EA VP  +TTYYF  L  L  A
Sbjct  4    SDGRRLKGEQRRQALIEATLRVIERDGVAGVSHRTVSQEAGVPTSATTYYFTGLGDLLTA  63

Query  65   ALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRPEL  124
            AL    +  ++ + +  S  D+ RDLA  L+++ +    D  R     EL++ AA +P L
Sbjct  64   ALTGVMDEDSERMRRMSSGGDRRRDLAELLSKVAS----DPGRLLAEYELFLLAARQPHL  119

Query  125  QRLARLWPDGLLALLEPRIGR--RAANAVTVFFDGATLHALITGTPLSTDEL  174
            +     W   + A          R  N   V  DG  LH L++      DE 
Sbjct  120  REATDRWLAAVSAFARCYTDDPVRVRNVAAV-IDGILLHTLLSDHKPDADEF  170


>gi|257057801|ref|YP_003135633.1| hypothetical protein Svir_38620 [Saccharomonospora viridis DSM 
43017]
 gi|256587673|gb|ACU98806.1| uncharacterized conserved protein [Saccharomonospora viridis 
DSM 43017]
Length=186

 Score = 78.2 bits (191),  Expect = 7e-13, Method: Compositional matrix adjust.
 Identities = 64/168 (39%), Positives = 85/168 (51%), Gaps = 15/168 (8%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I+EA  RVI R G+ G++HR VA EA VP  STTY+F+ LD L  A L   A    
Sbjct  15   RRQEIIEATLRVIERDGVAGVTHRTVAKEAGVPTTSTTYHFSSLDDLLIATLISCAR---  71

Query  75   DLLAQWRSDLDKDRDLAATLARLTTVYLAD---QDRYRTL--NELYMAAAHRPELQRLAR  129
            D+  +    +D+ R   +  A      LA+     R RT+   ELY+ AA RPEL+  AR
Sbjct  72   DMATEVYWMIDRARSRGSRGADEVANLLAEAIGPRRGRTMAEYELYLLAARRPELRPAAR  131

Query  130  LWPDGLLALLEPRIGRRAANAVTVFF---DGATLHALITGTPLSTDEL  174
             W D L ++    +      A  VF    DG  +  LI   P + +EL
Sbjct  132  RWLDVLTSM----VRHDDEVAFRVFLAGIDGLLIQGLIDDEPPTAEEL  175


>gi|302531180|ref|ZP_07283522.1| predicted protein [Streptomyces sp. AA4]
 gi|302440075|gb|EFL11891.1| predicted protein [Streptomyces sp. AA4]
Length=186

 Score = 77.8 bits (190),  Expect = 8e-13, Method: Compositional matrix adjust.
 Identities = 64/168 (39%), Positives = 85/168 (51%), Gaps = 15/168 (8%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RR  I+EA  RVI R G+ G++HR VAAEA VP  STTY+F+ LD L  A L   A    
Sbjct  15   RRTEIIEATLRVIERDGVAGVTHRTVAAEAGVPTTSTTYHFSSLDDLLVATLISCAR---  71

Query  75   DLLAQWRSDLDKDRDLAATLARLTTVYLADQ---DRYRTL--NELYMAAAHRPELQRLAR  129
            D+  +    +D+ R   +  A      LA+     R RT+   ELY+ AA +PEL+  AR
Sbjct  72   DMATEVYWMIDRARSRGSRGAEEVAGLLAEALGPRRGRTMAEYELYLLAARKPELRPAAR  131

Query  130  LWPDGLLALLEPRIGRRAANAVTVFF---DGATLHALITGTPLSTDEL  174
             W D L ++    +      A  VF    DG  +  LI   P S +EL
Sbjct  132  RWLDVLTSM----VRHDDEVAFRVFLAGIDGLLIQGLIDDEPPSAEEL  175


>gi|283784609|ref|YP_003364474.1| TetR family transcriptional regulator [Citrobacter rodentium 
ICC168]
 gi|282948063|emb|CBG87628.1| TetR-family transcriptional regulator [Citrobacter rodentium 
ICC168]
Length=193

 Score = 77.8 bits (190),  Expect = 8e-13, Method: Compositional matrix adjust.
 Identities = 56/189 (30%), Positives = 92/189 (49%), Gaps = 12/189 (6%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            RR  DP  RR+ I+ A    +   G+  ++HR++AA A+VP+GS TYYF+ +D L    L
Sbjct  2    RRANDPQ-RREKIITATLEAVKEHGIHAVTHRKIAAIADVPLGSLTYYFSGIDEL----L  56

Query  67   AHAANASADLL-AQWRSDLDKDRDLAATLARLTTVYLADQ----DRYRTLNELYMAAAHR  121
            + A N   D++ AQ+++      D       +  +  + Q    +    + +LY  A+ +
Sbjct  57   SEAFNCFTDVMSAQYQAFFSGVTDAQGACQAIAEMIDSSQVTTPENMALMYQLYAFASRK  116

Query  122  PELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARL  181
            P L+ + + W       LE       A A+  F +G TLH +    PLS +E+   + R+
Sbjct  117  PALKTVMQNWMQRSQQTLEQWFDPGTARALDAFIEGMTLHFVTDRAPLSREEILLMVRRV  176

Query  182  VADGPEQRE  190
               G E RE
Sbjct  177  A--GEEVRE  183


>gi|336249446|ref|YP_004593156.1| putative DeoR-type transcriptional regulator [Enterobacter aerogenes 
KCTC 2190]
 gi|334735502|gb|AEG97877.1| putative DeoR-type transcriptional regulator [Enterobacter aerogenes 
KCTC 2190]
Length=184

 Score = 77.8 bits (190),  Expect = 9e-13, Method: Compositional matrix adjust.
 Identities = 52/182 (29%), Positives = 87/182 (48%), Gaps = 8/182 (4%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            RRP DP  RR+ I++A    IA  G+  ++HR++A+ A VP+GS TYYF+ ++AL E A 
Sbjct  3    RRPNDPQ-RRERILQATLDTIAAHGIHAVTHRKIASCAGVPLGSLTYYFSGIEALIEEAF  61

Query  67   AHAANASADLLAQWRSDLD----KDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRP  122
                N + ++ AQ++   D    + +   A    + +  +        + +LY   + RP
Sbjct  62   ---RNFTVEMSAQYQQFFDGVGSRQQACDAIAELIFSAQVTTARNMELMYQLYAFCSSRP  118

Query  123  ELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
             L+ + + W       LE       A  +  F +G TLH +    PLS   +   + RL 
Sbjct  119  ALKTVMQSWMLRSQQTLEQWFEPATARGLDAFIEGMTLHFVTDSAPLSKAAIRLMVGRLA  178

Query  183  AD  184
             +
Sbjct  179  GE  180


>gi|324112718|gb|EGC06694.1| tetR family protein regulatory protein [Escherichia fergusonii 
B253]
Length=179

 Score = 77.8 bits (190),  Expect = 9e-13, Method: Compositional matrix adjust.
 Identities = 45/176 (26%), Positives = 83/176 (48%), Gaps = 2/176 (1%)

Query  7    RRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAAL  66
            RR  DP  RR+ I+ A    IA  G+  ++HR++A  A VP+GS TYYF+ +D L   A 
Sbjct  2    RRSNDPQ-RREKIIAATLEAIATHGIHAVTHRKIAIIAQVPLGSLTYYFSGIDELLTIAF  60

Query  67   AHAANASADLLAQWRSDLDKDRDLAATLARLT-TVYLADQDRYRTLNELYMAAAHRPELQ  125
                    +    + + + +  +    +  +  +  +   ++   + +LY  A+ +P L+
Sbjct  61   RRFTEIMTEQYQSFFTGVSEPIEACEAITEMIHSAQITTPEKMALMYQLYAFASRKPALK  120

Query  126  RLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARL  181
            ++ + W       L+       A A+  F +G TLH +    PL+ DE+   + R+
Sbjct  121  KVMQNWMHSSQQTLQQWFDPDTARALDAFIEGMTLHFVTDSKPLTRDEILKMVKRI  176


>gi|134101872|ref|YP_001107533.1| TetR family transcriptional regulator [Saccharopolyspora erythraea 
NRRL 2338]
 gi|291008598|ref|ZP_06566571.1| TetR family transcriptional regulator [Saccharopolyspora erythraea 
NRRL 2338]
 gi|133914495|emb|CAM04608.1| TetR-family transcriptional regulator [Saccharopolyspora erythraea 
NRRL 2338]
Length=295

 Score = 77.4 bits (189),  Expect = 1e-12, Method: Compositional matrix adjust.
 Identities = 70/184 (39%), Positives = 96/184 (53%), Gaps = 6/184 (3%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            RP+DPA RR+ I  AA  V+A +G+  L+HR VAA A VP+GSTTYYF +LD L   AL 
Sbjct  115  RPKDPA-RRERIARAAISVVAERGIEKLTHRAVAAAAGVPLGSTTYYFANLDDLLAEALR  173

Query  68   HAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTL--NELYMAAAHRPELQ  125
             AA      L +W   LD   D AA LA L   YL  + R RT+  +ELY+AA HRP L 
Sbjct  174  QAAGDDVAQLREWARGLDPSADFAAALADLVLHYLGPE-RSRTVVEHELYVAALHRPALA  232

Query  126  RLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADG  185
             ++  W   L               ++  F G  L  ++  +  + DE+     R++  G
Sbjct  233  HVSTEWDAALAEEFTAHTDPVTGKVLSALFCGLLLQGVVRESVPTRDEIETLFRRVL--G  290

Query  186  PEQR  189
            P ++
Sbjct  291  PAEK  294


>gi|333955922|gb|EGL73629.1| hypothetical protein CSE899_05067 [Cronobacter sakazakii E899]
Length=181

 Score = 77.4 bits (189),  Expect = 1e-12, Method: Compositional matrix adjust.
 Identities = 58/180 (33%), Positives = 89/180 (50%), Gaps = 12/180 (6%)

Query  8    RPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALA  67
            R  DP  RR+ I+EA    IA  G   ++HR++A EA VP+GS TYYF  L+AL   A  
Sbjct  4    RQNDP-QRRERILEATLACIATHGFHHITHRKIALEAGVPLGSVTYYFTSLEALLAEAFT  62

Query  68   HAANASAD----LLAQWRSDLDKDRDLAATL--ARLTTVYLADQDRYRTLNELYMAAAHR  121
              A + +     L+AQ +S  +    L A +  A++TT      +    + +LY  A+ +
Sbjct  63   RFAESMSRQYQALMAQAQSREEACEALTALICGAQVTT-----PENMELMYQLYAYASRQ  117

Query  122  PELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARL  181
            P+L+ + + W       LE       A A+  F +G TLH ++   PL   E+   + RL
Sbjct  118  PQLKIIMQDWMRRSQQTLETWFDPATARALDAFVEGMTLHYVVDREPLKEAEIRVIVLRL  177


>gi|345014301|ref|YP_004816655.1| TetR family transcriptional regulator [Streptomyces violaceusniger 
Tu 4113]
 gi|344040650|gb|AEM86375.1| transcriptional regulator, TetR family [Streptomyces violaceusniger 
Tu 4113]
Length=189

 Score = 77.4 bits (189),  Expect = 1e-12, Method: Compositional matrix adjust.
 Identities = 65/173 (38%), Positives = 88/173 (51%), Gaps = 8/173 (4%)

Query  15   RRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASA  74
            RRQ I++AA  V+   G+GGL HR VAA A+VP+GSTTY+F  LD L  AAL      +A
Sbjct  9    RRQRIIDAAAAVVRESGIGGLGHRAVAAAADVPLGSTTYHFATLDDLLIAALRQ---INA  65

Query  75   DLLAQ---WRSDLDKDRDLAATLAR-LTTVYLADQDRYRTLNELYMAAAHRPELQRLARL  130
            + LA+   W   +D     A  LAR L   +  D+ R     ELY AA     L+ LA  
Sbjct  66   EWLAEVRHWVEGVDPAAPPADELARWLGEQFTGDRARMELEYELYFAALRHEGLRPLAAE  125

Query  131  WPDGLLALLEPRI-GRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLV  182
              D +  +L   +     A AV    DG TL  L+   P   +  + A+AR++
Sbjct  126  CLDEMARMLTRLVPDATTARAVVALIDGLTLQVLLADRPYDREGTSAALARIM  178



Lambda     K      H
   0.319    0.132    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 

Effective search space used: 220408776486


  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Sep 5, 2011  4:36 AM
  Number of letters in database: 5,219,829,388
  Number of sequences in database:  15,229,318



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40