BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3121 Length=400 Score E Sequences producing significant alignments: (Bits) Value gi|15610258|ref|NP_217637.1| cytochrome P450 141 [Mycobacterium ... 816 0.0 gi|15842692|ref|NP_337729.1| P450 heme-thiolate protein [Mycobac... 814 0.0 gi|306973549|ref|ZP_07486210.1| hypothetical protein TMJG_03295 ... 714 0.0 gi|167970215|ref|ZP_02552492.1| putative cytochrome p450 141 CYP... 704 0.0 gi|254552204|ref|ZP_05142651.1| cytochrome P450 141 cyp141 [Myco... 702 0.0 gi|294995482|ref|ZP_06801173.1| cytochrome P450 141 cyp141 [Myco... 484 1e-134 gi|260667419|gb|ACX47922.1| cytochrome P450 141 [Mycobacterium t... 436 3e-120 gi|4731332|gb|AAD28449.1|AF127374_4 cytochrome P450 hydroxylase ... 234 2e-59 gi|561882|gb|AAA92553.1| cytochrome P-450 [Streptomyces antibiot... 231 2e-58 gi|294633864|ref|ZP_06712421.1| cytochrome P450 hydroxylase [Str... 229 6e-58 gi|45124724|emb|CAE53712.1| putative cytochrome P450 [Streptomyc... 229 9e-58 gi|297196501|ref|ZP_06913899.1| cytochrome P450 [Streptomyces pr... 228 1e-57 gi|238059587|ref|ZP_04604296.1| cytochrome P450-like enzyme [Mic... 226 7e-57 gi|284034218|ref|YP_003384149.1| cytochrome P450 [Kribbella flav... 224 1e-56 gi|254393795|ref|ZP_05008910.1| NocL [Streptomyces clavuligerus ... 222 9e-56 gi|325929638|gb|ADZ45320.1| cytochrome P450 [Streptomyces sp. NR... 222 1e-55 gi|316997108|dbj|BAJ52696.1| putative cytochrome P450 [Streptomy... 217 2e-54 gi|158431345|pdb|2Z36|A Chain A, Crystal Structure Of Cytochrome... 217 3e-54 gi|86262116|dbj|BAE78751.1| cytochrome P450 type compactin 3'',4... 217 3e-54 gi|271966289|ref|YP_003340485.1| cytochrome P450 [Streptosporang... 216 4e-54 gi|290960699|ref|YP_003491881.1| monooxygenase P450 [Streptomyce... 216 5e-54 gi|238062359|ref|ZP_04607068.1| cytochrome P450 [Micromonospora ... 214 2e-53 gi|345011734|ref|YP_004814088.1| cytochrome P450 [Streptomyces v... 213 4e-53 gi|120431554|gb|ABM21740.1| PdmW [Actinomadura hibisca] 211 2e-52 gi|300785817|ref|YP_003766108.1| cytochrome P450 [Amycolatopsis ... 209 6e-52 gi|256378615|ref|YP_003102275.1| cytochrome P450 [Actinosynnema ... 209 7e-52 gi|157384619|gb|ABV49597.1| cytochrome P450 [Streptomyces euryth... 208 1e-51 gi|311900397|dbj|BAJ32805.1| putative cytochrome P450 [Kitasatos... 207 3e-51 gi|159038783|ref|YP_001538036.1| cytochrome P450 [Salinispora ar... 207 4e-51 gi|134098012|ref|YP_001103673.1| cytochrome P450-like enzyme [Sa... 206 4e-51 gi|26541527|gb|AAN85514.1|AF484556_36 cytochrome P450 hydroxylas... 206 4e-51 gi|324997918|ref|ZP_08119030.1| cytochrome P450 hydroxylase [Pse... 205 1e-50 gi|256375333|ref|YP_003098993.1| cytochrome P450 [Actinosynnema ... 205 1e-50 gi|45124720|emb|CAE53710.1| putative cytochrome P450 [Streptomyc... 204 2e-50 gi|329941121|ref|ZP_08290400.1| cytochrome P450 hydroxylase [Str... 203 3e-50 gi|112791729|gb|ABI22127.1| cytochrome P450 hydroxylase [Strepto... 203 5e-50 gi|294146926|ref|YP_003559592.1| putative cytochrome P450 [Sphin... 203 5e-50 gi|80279143|gb|ABB52528.1| cytochrome P-450 [Streptomyces sp. KC... 202 6e-50 gi|254385127|ref|ZP_05000460.1| cytochrome P-450 [Streptomyces s... 202 9e-50 gi|337763118|emb|CCB71826.1| Cytochrome P450-SU2 [Streptomyces c... 202 1e-49 gi|112419474|dbj|BAF02929.1| cytochrome P450 monooxygenase [Stre... 202 1e-49 gi|35186977|gb|AAQ84152.1| PlmT4 [Streptomyces sp. HK803] 202 1e-49 gi|45934783|gb|AAS79447.1| P450 [Streptomyces bikiniensis] 202 1e-49 gi|108863047|gb|ABG22116.1| epothilone b hydroxylase [Amycolatop... 201 1e-49 gi|14456620|dbj|BAB60855.1| cytochrome P450nor [Trichosporon cut... 201 2e-49 gi|300782805|ref|YP_003763096.1| cytochrome P450 [Amycolatopsis ... 201 2e-49 gi|271966572|ref|YP_003340768.1| cytochrome P450, nitric oxide r... 201 2e-49 gi|112419473|dbj|BAF02928.1| cytochrome P450 monooxygenase [Stre... 199 5e-49 gi|300787317|ref|YP_003767608.1| cytochrome P450 [Amycolatopsis ... 199 5e-49 gi|302541571|ref|ZP_07293913.1| cytochrome P450 107B1 (P450CVIIB... 199 6e-49 >gi|15610258|ref|NP_217637.1| cytochrome P450 141 [Mycobacterium tuberculosis H37Rv] gi|148662975|ref|YP_001284498.1| putative cytochrome p450 141 CYP141 [Mycobacterium tuberculosis H37Ra] gi|307085861|ref|ZP_07494974.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis SUMu012] gi|6226796|sp|O08362.1|CP141_MYCTU RecName: Full=Putative cytochrome P450 141 gi|2076696|emb|CAB08378.1| PROBABLE CYTOCHROME P450 141 CYP141 [Mycobacterium tuberculosis H37Rv] gi|148507127|gb|ABQ74936.1| putative cytochrome p450 141 CYP141 [Mycobacterium tuberculosis H37Ra] gi|308364603|gb|EFP53454.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis SUMu012] Length=400 Score = 816 bits (2108), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/400 (100%), Positives = 400/400 (100%), Gaps = 0/400 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR Sbjct 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD Sbjct 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV Sbjct 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP Sbjct 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA Sbjct 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF Sbjct 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 Query 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 400 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT Sbjct 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 400 >gi|15842692|ref|NP_337729.1| P450 heme-thiolate protein [Mycobacterium tuberculosis CDC1551] gi|148824314|ref|YP_001289068.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis F11] gi|253800153|ref|YP_003033154.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis KZN 1435] 51 more sequence titles Length=400 Score = 814 bits (2102), Expect = 0.0, Method: Compositional matrix adjust. Identities = 399/400 (99%), Positives = 400/400 (100%), Gaps = 0/400 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR Sbjct 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD Sbjct 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEP+TVHELAAHVDAAMSVCEIGDEEV Sbjct 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPETVHELAAHVDAAMSVCEIGDEEV 180 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP Sbjct 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA Sbjct 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF Sbjct 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 Query 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 400 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT Sbjct 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 400 >gi|306973549|ref|ZP_07486210.1| hypothetical protein TMJG_03295 [Mycobacterium tuberculosis SUMu010] gi|308232341|ref|ZP_07415769.2| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis SUMu001] gi|308380577|ref|ZP_07490429.2| hypothetical protein TMKG_02370 [Mycobacterium tuberculosis SUMu011] gi|308214216|gb|EFO73615.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis SUMu001] gi|308357082|gb|EFP45933.1| hypothetical protein TMJG_03295 [Mycobacterium tuberculosis SUMu010] gi|308361036|gb|EFP49887.1| hypothetical protein TMKG_02370 [Mycobacterium tuberculosis SUMu011] Length=351 Score = 714 bits (1843), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/351 (100%), Positives = 351/351 (100%), Gaps = 0/351 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR Sbjct 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD Sbjct 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV Sbjct 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP Sbjct 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA Sbjct 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAY 351 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAY Sbjct 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAY 351 >gi|167970215|ref|ZP_02552492.1| putative cytochrome p450 141 CYP141 [Mycobacterium tuberculosis H37Ra] Length=346 Score = 704 bits (1817), Expect = 0.0, Method: Compositional matrix adjust. Identities = 345/346 (99%), Positives = 346/346 (100%), Gaps = 0/346 (0%) Query 55 VLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 114 +LSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV Sbjct 1 MLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 60 Query 115 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCE 174 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCE Sbjct 61 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCE 120 Query 175 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 234 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI Sbjct 121 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 180 Query 235 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV 294 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV Sbjct 181 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV 240 Query 295 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM 354 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM Sbjct 241 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM 300 Query 355 CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 400 CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT Sbjct 301 CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 346 >gi|254552204|ref|ZP_05142651.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|323718208|gb|EGB27388.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis CDC1551A] gi|339295953|gb|AEJ48064.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis CCDC5079] gi|339299563|gb|AEJ51673.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis CCDC5180] Length=346 Score = 702 bits (1813), Expect = 0.0, Method: Compositional matrix adjust. Identities = 344/346 (99%), Positives = 346/346 (100%), Gaps = 0/346 (0%) Query 55 VLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 114 +LSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV Sbjct 1 MLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 60 Query 115 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCE 174 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEP+TVHELAAHVDAAMSVCE Sbjct 61 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPETVHELAAHVDAAMSVCE 120 Query 175 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 234 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI Sbjct 121 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 180 Query 235 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV 294 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV Sbjct 181 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV 240 Query 295 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM 354 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM Sbjct 241 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM 300 Query 355 CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 400 CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT Sbjct 301 CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT 346 >gi|294995482|ref|ZP_06801173.1| cytochrome P450 141 cyp141 [Mycobacterium tuberculosis 210] Length=243 Score = 484 bits (1245), Expect = 1e-134, Method: Compositional matrix adjust. Identities = 240/243 (99%), Positives = 242/243 (99%), Gaps = 0/243 (0%) Query 55 VLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 114 +LSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV Sbjct 1 MLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 60 Query 115 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCE 174 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEP+TVHELAAHVDAAMSVCE Sbjct 61 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPETVHELAAHVDAAMSVCE 120 Query 175 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 234 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI Sbjct 121 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 180 Query 235 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV 294 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP TEIEHLRVVTEDV Sbjct 181 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPGTEIEHLRVVTEDV 240 Query 295 VIA 297 VIA Sbjct 241 VIA 243 >gi|260667419|gb|ACX47922.1| cytochrome P450 141 [Mycobacterium tuberculosis] Length=215 Score = 436 bits (1122), Expect = 3e-120, Method: Compositional matrix adjust. Identities = 214/215 (99%), Positives = 215/215 (100%), Gaps = 0/215 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR Sbjct 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD Sbjct 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEP+TVHELAAHVDAAMSVCEIGDEEV Sbjct 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPETVHELAAHVDAAMSVCEIGDEEV 180 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANR 215 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANR Sbjct 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANR 215 >gi|4731332|gb|AAD28449.1|AF127374_4 cytochrome P450 hydroxylase [Streptomyces lavendulae] Length=410 Score = 234 bits (596), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 131/393 (34%), Positives = 205/393 (53%), Gaps = 2/393 (0%) Query 7 PTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAA 66 P +PF P EP P LR P+ + LP G AWL TR+ DV+ V +D+RFS + A Sbjct 19 PAYPFHAPDRLEPDPYWEPLRRERPLQRVTLPYGGEAWLATRYQDVRAVFADRRFSRQLA 78 Query 67 AHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDL 126 P +P F+P ++LS++GP H RRL+ + P + MRP++Q+ D LD + Sbjct 79 VAPGAPRFLPHQPPPDAVLSVEGPDHARLRRLVGKVFTPRRVEDMRPLIQRTADGLLDAM 138 Query 127 AAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSA 186 PP D E S+P ++ +LLGV P+ DA ++ +V Sbjct 139 EEMGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCVWSDALLTTTAHTPAQVRDYMMQ 198 Query 187 LCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITN 246 + + ++ ++ P DL+ ++ A ++ +T+ ++V + ++I G +T + I N Sbjct 199 MHDYLGGLVAQRRVRPTADLIGSLVTARDEEDKLTEGELVRLAEAILIAGYETSASQIPN 258 Query 247 GLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTALSAGS 305 L L H ER+ D + AVEE++RF P ++ R TEDV + G + AG Sbjct 259 FLYVLFRHPQLLERIRNDHDLIPDAVEELLRFVPIGTVDGFPRTATEDVELGGVLVRAGE 318 Query 306 PAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQ 365 S+ +ANRD + F DPDE D+ R PN H+ FG GPH C + +R+ L T+L + Sbjct 319 TVVPSMGAANRDPELFTDPDELDLARRPNPHLGFGAGPHHCLGAQLARVELQITLTTLFR 378 Query 366 RFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 R+P+L+LA P E L + +GL G+ + VTW Sbjct 379 RYPRLRLAVPEESLSWK-EGLMVRGMHTMPVTW 410 >gi|561882|gb|AAA92553.1| cytochrome P-450 [Streptomyces antibioticus] Length=407 Score = 231 bits (588), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 138/396 (35%), Positives = 206/396 (53%), Gaps = 3/396 (0%) Query 5 SIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGH-TAWLVTRFDDVKGVLSDKRFSC 63 ++P +PF P + P +ELR PV+ + LP G TAWLVTR D + VL D RFS Sbjct 13 AVPAYPFSLPHALDLDPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDARIVLGDSRFST 72 Query 64 RAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNAL 123 AA P++P P +L+ D P HT RRL+ + + MRP V+ +VD+ L Sbjct 73 AAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRSLVDSLL 132 Query 124 DDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRR 183 DD+ A P D E ++VP ++ +LLGV + DA +S + E+ R Sbjct 133 DDMVAHGSPADLVEFLAVPFPVAVICELLGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRV 192 Query 184 WSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAV 243 + ++ ++ P +DLL +A A +T ++V M ++++I G +T + Sbjct 193 QQDFMVYMDGLVAQRRDAPTEDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQ 252 Query 244 ITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEI-EHLRVVTEDVVIAGTALS 302 ITN + LL R +YE LV DP V AVEE++R+ P +RV TEDV ++ + Sbjct 253 ITNLVHLLLTERKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVR 312 Query 303 AGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTS 362 AG P SANRD + F DE D R N HIAFG+G H C + R+ L ++ Sbjct 313 AGEPCVVHFASANRDEEVFDHADELDFHRERNPHIAFGHGAHHCIGAQLGRLELQEALSA 372 Query 363 LTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 L +RFP L LA P L+ + +G+ G++ +V+W Sbjct 373 LVRRFPTLDLAEPVAGLKWK-QGMLIRGLERQIVSW 407 >gi|294633864|ref|ZP_06712421.1| cytochrome P450 hydroxylase [Streptomyces sp. e14] gi|292830116|gb|EFF88468.1| cytochrome P450 hydroxylase [Streptomyces sp. e14] Length=400 Score = 229 bits (584), Expect = 6e-58, Method: Compositional matrix adjust. Identities = 137/399 (35%), Positives = 206/399 (52%), Gaps = 3/399 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MT ++ +PF P +LR + P+ P+ LP G AWLVTR++DVK VL D R Sbjct 1 MTISNPRPYPFKATDELYVEPRFEQLRENEPLCPVRLPHGEAAWLVTRYEDVKTVLGDPR 60 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FS A P P+ L ++L D P+HT RR++A+ + +R Q I D Sbjct 61 FSRARAVTEDEPRTRPYRGLPGNILEFDPPEHTRLRRVVAKAFTVRRVEELRVRAQAIAD 120 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 +D + A PP D ++P+ ++ +LLGV + DA +S EEV Sbjct 121 GLVDAMTAQGPPADLVAGFALPLPVTVICELLGVPLEDRTRFRLWSDALLSTTRFTPEEV 180 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 R L + ++ + EP DDLL + A ++ ++++++V M + V++ G +T Sbjct 181 ERYAGELSAYMAALIAERRKEPTDDLLGVMVAARDEEERLSEDELVAMGVGVLVAGHETT 240 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 + I N + +LL H DQ RL D V +AVEE++RF P + R EDV ++G Sbjct 241 ASQIPNFVHTLLDHPDQLARLRADLDLVPQAVEELMRFVPLGDAGIARYALEDVELSGGV 300 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 + AG P TS +ANRD+ F P+E D+ R H+ FG+GPH C + +RM L Sbjct 301 VRAGEPVVTSNVAANRDAAVFTRPEELDLTRQEASHVGFGHGPHHCLGAQLARMELQVTL 360 Query 361 TSLTQRFPQLQLARPFEDLERR-GKGLHSVGIKELLVTW 398 +L R P L+LA DLER+ G G+ G ++LVTW Sbjct 361 RTLLTRLPGLRLAGTGADLERKTGSGVK--GFSKMLVTW 397 >gi|45124724|emb|CAE53712.1| putative cytochrome P450 [Streptomyces peucetius ATCC 27952] Length=414 Score = 229 bits (583), Expect = 9e-58, Method: Compositional matrix adjust. Identities = 128/393 (33%), Positives = 203/393 (52%), Gaps = 2/393 (0%) Query 7 PTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAA 66 P +PF P EP P LR P+ + LP G AWL TR+ DV+ V +D+RFS A Sbjct 23 PAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAWLATRYQDVRKVFADRRFSRALA 82 Query 67 AHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDL 126 P +P F+P ++LS++GP H RRL+ + P + MRP++Q D LD + Sbjct 83 VAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFTPRRVEAMRPLIQSTADRLLDAM 142 Query 127 AAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSA 186 PP D E S+P ++ +LLGV P+ DA ++ +V Sbjct 143 EEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCTWSDALLTTTAHTPAQVRDHMMQ 202 Query 187 LCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITN 246 + + ++ ++ P +DL+ ++ A + +T+ ++V + ++I G +T + I N Sbjct 203 MHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGELVRLAEAILIAGYETSASQIPN 262 Query 247 GLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTALSAGS 305 L L + ERL D + AVEE++R+ P ++ R TEDV + G + AG Sbjct 263 FLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTVDGFPRTATEDVELGGVLIRAGE 322 Query 306 PAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQ 365 S+ +ANRD + F DP+E D+ R+PN H+ FG GPH C + +R+ L T+L + Sbjct 323 TVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGPHHCLGAQLARVELQITLTTLFR 382 Query 366 RFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 R+P+L+LA P E L + GL G+ + +TW Sbjct 383 RYPRLRLAVPEESLAWKA-GLMVRGMHTMPITW 414 >gi|297196501|ref|ZP_06913899.1| cytochrome P450 [Streptomyces pristinaespiralis ATCC 25486] gi|297153247|gb|EDY66768.2| cytochrome P450 [Streptomyces pristinaespiralis ATCC 25486] gi|302607811|emb|CBW45722.1| putative cytochrome P450 hydroxylase [Streptomyces pristinaespiralis] Length=436 Score = 228 bits (582), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 148/403 (37%), Positives = 218/403 (55%), Gaps = 17/403 (4%) Query 7 PTFPFDRPVPTEPSPML------SELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 P FPFD TEP P L + LR+ CPV + LP G +LV+R+ DVK VL+D+R Sbjct 40 PAFPFD----TEPGPPLEVPQEFTRLRDRCPVQRVRLPYGGEGYLVSRYADVKQVLADRR 95 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FS A P V V LL++D P+HT RRL+A I R RP +QQIVD Sbjct 96 FSRAATVGKDVPRTVREVTAPGHLLAMDPPEHTRLRRLVAAAFTERSIQRRRPRIQQIVD 155 Query 121 NALDDL---AAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGD 177 + +D L AA VD S+P+ ++ +LLGV P H + A S + Sbjct 156 DLVDGLRARAAGGEAVDLVAHFSMPLPMTVICELLGVPPGDRHYFQRVAEVAFSNGAVDP 215 Query 178 EEVSRRWSALCTMVIDILHRKLAEPGDDLLST-IAQANRQQSTMTDEQVVGMLLTVVIGG 236 +E+ + A T + + R PGDDL+S IA + Q +T+ +++ + T+++ G Sbjct 216 QEMQQVGEAFGTYLTGHIARLRERPGDDLMSQMIAARDEDQDRLTEAELISLAGTLLLAG 275 Query 237 VDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVV 295 +T A I+N + +LL H D++ LV+ P + AVEE++R+ + L R+ TED+ Sbjct 276 YETTAAEISNFVYTLLEH-DRWSWLVDHPEHLDTAVEELLRYIALGGGDVLPRLATEDID 334 Query 296 IAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMC 355 + GT L G+ ++ SANRD F DPD D+ER+PN H+AFG+GPH C + +R+ Sbjct 335 VGGTVLPEGASVIAAMISANRDGHVFPDPDVLDLERSPNPHVAFGHGPHHCTGAQLARLE 394 Query 356 LTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 L SL + FP L+LA P + R +G G ++LL+ W Sbjct 395 LRVALASLLRAFPALRLAVPAAQVPWR-QGSLVRGPRQLLLRW 436 >gi|238059587|ref|ZP_04604296.1| cytochrome P450-like enzyme [Micromonospora sp. ATCC 39149] gi|237881398|gb|EEP70226.1| cytochrome P450-like enzyme [Micromonospora sp. ATCC 39149] Length=396 Score = 226 bits (575), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 131/392 (34%), Positives = 209/392 (54%), Gaps = 5/392 (1%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +P + P +P+ S+LR S PV ++P G +WL + D K V+ D RFS RA AH Sbjct 8 YPLEEDGPPRLNPLYSQLRESKPVLRAQMPYGEESWLTLKHSDFKFVMGDSRFS-RALAH 66 Query 69 PSSPPFVPFVQLCP-SLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLA 127 S P V F ++ +++ +D P+H R+++ +G +A+ RP +QQIVD LD++ Sbjct 67 ASDEPRV-FPEMPDINIMRMDPPEHGKLRKIVTRGFTERRVAQWRPQIQQIVDELLDEME 125 Query 128 AAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSAL 187 A PPV+ P+ ++A +LGV + A ++ + E++ Sbjct 126 EAGPPVNLVTAFGTPLPATVIAMMLGVPVEDRPLFTEWSKAMIATTSMPVEQIRDYLDKQ 185 Query 188 CTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNG 247 V D++ ++ EP DD++S +A A + +T+E++VG+ + ++ G + I+ G Sbjct 186 HRYVADMVADRIREPRDDMISDLAAAYQSNDGITEEEIVGLGMFLLATGHGSTANQISYG 245 Query 248 LASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTALSAGSP 306 L H +++ +LV DP A +E++R+ E R TEDV ++GT + AG P Sbjct 246 TYVLFSHPEEWAKLVADPTLAKTAADELLRYALNDEAAIFSRYATEDVEVSGTLVRAGEP 305 Query 307 AFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQR 366 S SAN D F DP+ D+ R+PN H+ FGYG H CP + +R + F SL +R Sbjct 306 VLPSRVSANYDDTVFKDPERLDISRSPNPHVTFGYGLHYCPGAGLARAQMQIAFESLVRR 365 Query 367 FPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 FP+LQ A P E+LE +G L +EL VTW Sbjct 366 FPKLQPAVPLEELEWKGGSLART-FEELPVTW 396 >gi|284034218|ref|YP_003384149.1| cytochrome P450 [Kribbella flavida DSM 17836] gi|283813511|gb|ADB35350.1| cytochrome P450 [Kribbella flavida DSM 17836] Length=404 Score = 224 bits (572), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 134/386 (35%), Positives = 213/386 (56%), Gaps = 6/386 (1%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MT T + PFD +PSP +ELR + PVA + +G WLVTR+DDV+ VL+D R Sbjct 1 MTDTVL-DIPFDDAFRFDPSPTFAELRENRPVARVRTLAGAEVWLVTRYDDVRLVLADPR 59 Query 61 FSCRAAAHPSSPPFVPFVQLCP-SLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIV 119 FS RAA P V + P SL + D P+HT R+L++ I R RP V ++ Sbjct 60 FS-RAAVVEQGAPRVALAKPMPNSLTTTDPPEHTRLRKLVSSTFAHRRIERTRPWVAELS 118 Query 120 DNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEE 179 DD+AAA D +++V++P+ Q++ +LLGV + + + S+ + Sbjct 119 ARLADDVAAAGDGADLRQLVALPLPIQVICQLLGVPYQDREQFREWTELGYSMRMAEKDL 178 Query 180 VSRRWSALCTMVIDILHRKLA---EPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGG 236 V + L + ++ RKLA +P DDLL + +A ++ ++++ + +++ G Sbjct 179 VENAMTELTAYIEALVDRKLATADQPADDLLDELVRAREAGDRLSQQELIAFGVNLLVAG 238 Query 237 VDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVI 296 +T I++ +A+LL + + RLV D V AVEE++RFN +E+ LRV EDV + Sbjct 239 HETSANQISSCVATLLRRPENWARLVADHTLVPSAVEELLRFNRFSEVGQLRVAVEDVEL 298 Query 297 AGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCL 356 G + AG ++ SANRD + PDE ++R N+H++FG+GPH C + +R+ L Sbjct 299 HGVLIKAGEGVMAALNSANRDPRAYDAPDELRLDRQDNKHLSFGFGPHFCLGAQLARIEL 358 Query 357 TTFFTSLTQRFPQLQLARPFEDLERR 382 +L +RFP+L LA+P E+LE R Sbjct 359 QESLLALLRRFPELSLAKPAEELEWR 384 >gi|254393795|ref|ZP_05008910.1| NocL [Streptomyces clavuligerus ATCC 27064] gi|294811320|ref|ZP_06769963.1| cytochrome P450-like enzyme [Streptomyces clavuligerus ATCC 27064] gi|326439946|ref|ZP_08214680.1| P450-like monoxygenase [Streptomyces clavuligerus ATCC 27064] gi|197707397|gb|EDY53209.1| NocL [Streptomyces clavuligerus ATCC 27064] gi|294323919|gb|EFG05562.1| cytochrome P450-like enzyme [Streptomyces clavuligerus ATCC 27064] Length=411 Score = 222 bits (565), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 131/393 (34%), Positives = 209/393 (54%), Gaps = 4/393 (1%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +PF RP + P+ LR CPVA + LPSG ++V+R+DDV+ VL+D RFS A Sbjct 20 YPFPRPSAVQVPPVYDRLRGECPVAKVRLPSGDDGYVVSRYDDVRTVLADPRFSRAAMLA 79 Query 69 PSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAA 128 +P + SL ++D P+HT RRL+++ + +RP +Q++ D LD + Sbjct 80 EGAPRLTAAPPMGGSLFTMDPPEHTRLRRLVSREFTARRVQNLRPRIQEMTDELLDGMEK 139 Query 129 AEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSALC 188 PPVD + P+ ++ +LLGV + DA +S+ EEV + ++ Sbjct 140 LSPPVDLNPAFAFPLPVMVICELLGVPFEDRDRFRGWSDAFVSLTSHTPEEVMEQRMSMV 199 Query 189 TMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDE-QVVGMLLTVVIGGVDTPIAVITNG 247 + +++ RK AEP DDL+ + Q + + E +++ M +T+++ G +T +++I Sbjct 200 QYLGELVQRKRAEPTDDLMGALVQVHDEDGGRLSEIELITMGITLLVAGHETTVSMIGTC 259 Query 248 LASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPA 307 +LL H + L DPG + + VEE++R NP + RV EDV +A + + GS Sbjct 260 ALTLLRHPEHLAALKADPGSIDKVVEELLRINPIGDGGPFRVTLEDVEVADSVIPQGSGV 319 Query 308 FTSITSANRDSDQF-LDPDEFDVER-NPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQ 365 ++ SAN+DS +F DP FD R + H+AFG+GPH C +A +R L +SL + Sbjct 320 IAAVCSANQDSARFGADPGVFDPSRPTASAHLAFGHGPHFCLGAALARAELQIALSSLFR 379 Query 366 RFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 RFP L LA +L R G+ + L VTW Sbjct 380 RFPGLALADEVRNL-RMTSGMMVHALSRLPVTW 411 >gi|325929638|gb|ADZ45320.1| cytochrome P450 [Streptomyces sp. NRRL 30471] Length=404 Score = 222 bits (565), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 134/405 (34%), Positives = 212/405 (53%), Gaps = 8/405 (1%) Query 1 MTST------SIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKG 54 MTST + P++PF + P + LR+ P+A + +P G AWLVTR++DV+ Sbjct 1 MTSTEGQAIPTAPSYPFRQARGLGIDPEFARLRHDAPLACVAMPYGGQAWLVTRYEDVRT 60 Query 55 VLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 114 VL D+RFS A P P VQ PS+L++D P HT RRL+++ P + +RP Sbjct 61 VLGDRRFSRAATLGRDIPRLTPLVQQVPSILTLDPPDHTRHRRLVSRAFTPRRMEELRPK 120 Query 115 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCE 174 V+Q VD +D+L PPVD V+ P+ ++ ++LGV H +A S Sbjct 121 VEQFVDELIDELLRHGPPVDMVAHVTRPLPVMVICEMLGVPFGERHLFYTWSEAMRSTGA 180 Query 175 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 234 ++ + + D + + P D+LL T+ +A ++ ++++++V +T+++ Sbjct 181 DAVAKMKQAGQLPWDYLADRISVERENPSDNLLGTLVRACDEEERLSEQELVSFAVTLLL 240 Query 235 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTED 293 G +T + N L +LL + E+L P + A+EE++RF P + R+ TED Sbjct 241 AGHETTTDELGNFLYTLLVNPAHREQLRARPHMLGTAIEELLRFVPIGTLSGFTRIATED 300 Query 294 VVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSR 353 V ++G + AG SANRD F DPDE D +R PN H+AFGYGPH C + +R Sbjct 301 VHLSGGLVRAGDAVVVQADSANRDESVFADPDELDFQREPNRHLAFGYGPHHCLGAQLAR 360 Query 354 MCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 + L +L R P L LA P ++ + G ++G + L VTW Sbjct 361 IELRAAIGALLTRLPALALAVPEHEVPWK-LGRSALGPQALPVTW 404 >gi|316997108|dbj|BAJ52696.1| putative cytochrome P450 [Streptomyces sp. TA-0256] Length=419 Score = 217 bits (553), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 142/392 (37%), Positives = 206/392 (53%), Gaps = 3/392 (0%) Query 8 TFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAA 67 +FPF P EP+P +ELR + + LP+G TAW+ TR++D + +LSD RFS AAA Sbjct 30 SFPFPAADPWEPAPEFAELRGRDRMGRVTLPTGDTAWIATRYEDNRQLLSDPRFSRAAAA 89 Query 68 HPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLA 127 +P SL ++D P+HT RR+ + + R+RP ++Q+ LD LA Sbjct 90 RAGAPRVRRAALETRSLTTMDPPEHTRLRRIAVRAFTTQSVDRLRPRIRQVTGGLLDTLA 149 Query 128 AAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSAL 187 AA P D V+ P+ +M +LLGV A +S EE+ ++L Sbjct 150 AAGPGADLVAEVARPLPVTVMCELLGVPAGDQARFGAWSRVYLSAVGHSAEEIESAAASL 209 Query 188 CTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNG 247 + ++ K PGDDLLS +A A ++ +E V +T+++ GV+T + I+ G Sbjct 210 KGYLARLIGDKRRRPGDDLLSRLAHAPEEERLDEEELVT-FGVTLLVAGVETVVHEISGG 268 Query 248 LASLLHHRDQYERLVEDPGRVARAVEEIVRFNPAT-EIEHLRVVTEDVVIAGTALSAGSP 306 + +LL +Q+ERL P + AVEE++RF PA LRV EDV + G + AG Sbjct 269 VLALLRAPEQWERLRARPALLDGAVEELIRFTPAAVSGGTLRVALEDVELGGVLVRAGEA 328 Query 307 AFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQR 366 ++ +A+RD F DPD DV R PN HI FG+GPH C + +R L SL R Sbjct 329 VLPAVIAADRDPGVFPDPDRLDVTRRPNPHIGFGHGPHRCLGAQLARAELGIALGSLIAR 388 Query 367 FPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 FP L+LA P +LE +G+ G K L V W Sbjct 389 FPGLRLAVPVTELEWVLQGMQR-GPKALPVRW 419 >gi|158431345|pdb|2Z36|A Chain A, Crystal Structure Of Cytochrome P450 Moxa From Nonomuraea Recticatena (Cyp105) gi|158431346|pdb|2Z36|B Chain B, Crystal Structure Of Cytochrome P450 Moxa From Nonomuraea Recticatena (Cyp105) Length=413 Score = 217 bits (552), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 138/397 (35%), Positives = 204/397 (52%), Gaps = 10/397 (2%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSC--RAA 66 P +R P P LR P+ + L SG AW V+ ++ + VL+D RFS R Sbjct 14 LPVERGCPFAPPAAYERLRERAPINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKD 73 Query 67 AHPSSPPFVPFVQLC----PSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNA 122 P +Q P +L +DG +H+AARR + +A +RP +Q IVD+ Sbjct 74 GFPLFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLAALRPRIQDIVDHF 133 Query 123 LDD-LAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVS 181 +DD LA + PVD + +S+P+ ++ +LLGV P T H+ M V E+ Sbjct 134 IDDMLATDQRPVDLVQALSLPVPSLVICELLGV-PYTDHDFF-QSRTTMMVSRTSMEDRR 191 Query 182 RRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPI 241 R ++ L + D++ RK +EPGDDL S RQ+ T+ +V + ++ G +T Sbjct 192 RAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETTA 251 Query 242 AVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTAL 301 +I+ G+ LL H +Q + +PGR AVEE++R+ + R+ TEDV I G ++ Sbjct 252 NMISLGVVGLLSHPEQLTVVKANPGRTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSI 311 Query 302 SAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFT 361 AG S+ SAN D F DP DVER H+AFG+GPH C +RM L F Sbjct 312 KAGEGVIVSMLSANWDPAVFKDPAVLDVERGARHHLAFGFGPHQCLGQNLARMELQIVFD 371 Query 362 SLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 +L +R P L+LA P ED+ +G + G+ EL VTW Sbjct 372 TLFRRIPSLRLAVPMEDVPFKGDSV-IYGVHELPVTW 407 >gi|86262116|dbj|BAE78751.1| cytochrome P450 type compactin 3'',4''-hydroxylase [Nonomuraea recticatena] Length=407 Score = 217 bits (552), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 138/397 (35%), Positives = 204/397 (52%), Gaps = 10/397 (2%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSC--RAA 66 P +R P P LR P+ + L SG AW V+ ++ + VL+D RFS R Sbjct 14 LPVERGCPFAPPAAYERLRERAPINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKD 73 Query 67 AHPSSPPFVPFVQLC----PSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNA 122 P +Q P +L +DG +H+AARR + +A +RP +Q IVD+ Sbjct 74 GFPLFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLAALRPRIQDIVDHF 133 Query 123 LDD-LAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVS 181 +DD LA + PVD + +S+P+ ++ +LLGV P T H+ M V E+ Sbjct 134 IDDMLATDQRPVDLVQALSLPVPSLVICELLGV-PYTDHDFF-QSRTTMMVSRTSMEDRR 191 Query 182 RRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPI 241 R ++ L + D++ RK +EPGDDL S RQ+ T+ +V + ++ G +T Sbjct 192 RAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETTA 251 Query 242 AVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTAL 301 +I+ G+ LL H +Q + +PGR AVEE++R+ + R+ TEDV I G ++ Sbjct 252 NMISLGVVGLLSHPEQLTVVKANPGRTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSI 311 Query 302 SAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFT 361 AG S+ SAN D F DP DVER H+AFG+GPH C +RM L F Sbjct 312 KAGEGVIVSMLSANWDPAVFKDPAVLDVERGARHHLAFGFGPHQCLGQNLARMELQIVFD 371 Query 362 SLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 +L +R P L+LA P ED+ +G + G+ EL VTW Sbjct 372 TLFRRIPSLRLAVPMEDVPFKGDSV-IYGVHELPVTW 407 >gi|271966289|ref|YP_003340485.1| cytochrome P450 [Streptosporangium roseum DSM 43021] gi|270509464|gb|ACZ87742.1| putative cytochrome P450 [Streptosporangium roseum DSM 43021] Length=405 Score = 216 bits (551), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 139/401 (35%), Positives = 202/401 (51%), Gaps = 11/401 (2%) Query 6 IPTFPFDRPV--PTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSC 63 +PTFP R P +PSP LS PV+ + L G T W+VTR DV+ +L+D R S Sbjct 8 MPTFPMARATGCPFDPSPELSRRLEEAPVSRVRLWDGSTPWMVTRHADVRALLADPRVSV 67 Query 64 RAAAHPSSPPFVPFVQL----CPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIV 119 AHP P + +L+ +D P+H A RRLL + +RP +Q+IV Sbjct 68 -DVAHPGFPHTNAVSKARDAHMKTLMQMDAPEHIAQRRLLTSDFMIRRMEALRPRIQRIV 126 Query 120 DNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEE 179 D+ +D++ A PVD E ++P+ ++ +LLG P T +L V + + E E+ Sbjct 127 DDLIDEMLAGPNPVDLVEAFALPVPSLVICELLGA-PYTARDLFHRVSRTLVMDEPDPEQ 185 Query 180 VSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDT 239 L + +++ K AEPGDDL S +A + MT ++ +++ G DT Sbjct 186 AMAASEELNAYLEELVDSKNAEPGDDLFSRLAVEQYRTGAMTRREIATAGQLLLVAGHDT 245 Query 240 PIAVITNGLASLLHHRDQYE--RLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIA 297 +I G A+LL H DQ R EDP VA A EE++R+ T E RV ED+ I Sbjct 246 TATMIALGTAALLAHPDQLSAVRDSEDPALVANAAEELLRYLSITHTEARRVAREDLEIG 305 Query 298 GTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLT 357 G + G + ANRD F DPD DV R H+AFG+G H C + +R+ L Sbjct 306 GRLIRRGDGIIAVKSIANRDPSAFPDPDALDVHRKARHHVAFGFGAHQCLGQSLARVELQ 365 Query 358 TFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 +++L +R P L LA P E L + + G++EL VTW Sbjct 366 VVYSTLYRRIPTLALAVPLEQLTFKENAVF-YGVRELPVTW 405 >gi|290960699|ref|YP_003491881.1| monooxygenase P450 [Streptomyces scabiei 87.22] gi|260650225|emb|CBG73341.1| P450-like monoxygenase [Streptomyces scabiei 87.22] Length=412 Score = 216 bits (551), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 129/393 (33%), Positives = 208/393 (53%), Gaps = 4/393 (1%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +PF RP E P+ ELR CPVA + LPSG ++V+R+DD + VL+D RFS A Sbjct 21 YPFHRPSAVEVPPVYEELRAKCPVAKVRLPSGDEGYVVSRYDDARVVLADPRFSRAAMLD 80 Query 69 PSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAA 128 +P + SL ++D P+HT RRL+++ + +RP +QQ+ D LDD+ Sbjct 81 EGAPRLTAAPPMPGSLFTMDAPEHTRVRRLVSREFTARRVQNLRPRIQQMTDELLDDMEK 140 Query 129 AEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSALC 188 PPVD + P+ ++ +LLGV + DA +S+ EEV + ++ Sbjct 141 LSPPVDLNPAFAFPLPVMVICELLGVPFEDRDRFRGWSDAFVSLTAHTAEEVMEQRMSMV 200 Query 189 TMVIDILHRKLAEPGDDLLST-IAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNG 247 + ++ RK EP DDL+S +A + +++ +++ M +T+++ G +T +++I Sbjct 201 QYLAQLVQRKREEPADDLMSALVAVHDEDGDRLSEHELITMGITLLVAGHETTVSMIGKC 260 Query 248 LASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPA 307 + +LL H + L E P + + VEE++R NP + RV EDV IAGT + GS Sbjct 261 VLTLLRHPEHLAALRERPETIDQVVEELLRINPIGDGGPFRVTLEDVEIAGTTIPKGSGV 320 Query 308 FTSITSANRDSDQF-LDPDEFDVER-NPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQ 365 ++ SAN+D ++F D FD R + H+A G+G H C +A +R L +SL + Sbjct 321 IAAVASANQDPERFGADSGVFDPARSSAGAHLALGHGAHFCLGAALARAELQIAVSSLIR 380 Query 366 RFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 RFP+L LA +L G+ + + VTW Sbjct 381 RFPRLALADEVGNLSLT-SGMMVHALSRMPVTW 412 >gi|238062359|ref|ZP_04607068.1| cytochrome P450 [Micromonospora sp. ATCC 39149] gi|237884170|gb|EEP72998.1| cytochrome P450 [Micromonospora sp. ATCC 39149] Length=400 Score = 214 bits (545), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 135/402 (34%), Positives = 203/402 (51%), Gaps = 6/402 (1%) Query 1 MTSTS---IPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLS 57 MT TS I +PF P P + LR P+ + LP G AWL TR DV+ VL Sbjct 1 MTDTSEATIQRYPFSDPDRLNLDPCYARLRRDEPLIRVRLPYGAPAWLATRHADVRIVLG 60 Query 58 DKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQ 117 D RFS AA P P Q+ +LS+D P+HT RRL+A+ + +RP +Q Sbjct 61 DARFSRAAAVGRDEPRNTPR-QIKGGILSMDPPEHTRLRRLVARAFTARRVEELRPRTRQ 119 Query 118 IVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGD 177 + D +D+L AA P D V+ P+ +++ LLGV +A +S+ + + Sbjct 120 VADELVDNLLAAGPAADLVAHVATPLPIRVICDLLGVPVADQDRFHTWSEAIVSITTLSE 179 Query 178 EEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGV 237 E++ + L + +++ R+ EP DDLLS + +A ++++++V + ++ G Sbjct 180 EQIEQYMGNLFAYMGELIARRREEPTDDLLSAMVRARDADDRLSEQEMVELAAGLLAAGH 239 Query 238 DTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVI 296 +T + I N + LL H D++ RL+ D V RAVEE++RF P R ED+ + Sbjct 240 ETTVTQIPNFVYVLLQHPDEWARLLADRTLVPRAVEELMRFVPLGATTAFARYAKEDIEV 299 Query 297 AGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCL 356 G + AG P SI SANRD F D D D+ R N H+ FG+G H C + +RM L Sbjct 300 GGVLVRAGEPVVVSIPSANRDETVFADADRLDLGREINPHLGFGHGVHHCVGAQLARMEL 359 Query 357 TTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 +L R P L+LA P +L + GL G+ + V W Sbjct 360 QVVLETLLDRTPGLRLAVPEPELTWK-SGLLVRGLTAMPVAW 400 >gi|345011734|ref|YP_004814088.1| cytochrome P450 [Streptomyces violaceusniger Tu 4113] gi|344038083|gb|AEM83808.1| cytochrome P450 [Streptomyces violaceusniger Tu 4113] Length=404 Score = 213 bits (543), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 127/404 (32%), Positives = 213/404 (53%), Gaps = 9/404 (2%) Query 3 STSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFS 62 + +IP +PF++P EP +E R +CPVA + +PSG L+T +++V+G+L+D RFS Sbjct 2 TEAIPDYPFEQPNALEPPREWAETRATCPVAHVRMPSGDVVGLLTGYEEVRGLLTDPRFS 61 Query 63 CR-----AAAHPSSPPFVPFVQLCPSLLSI-DGPQHTAARRLLAQGLNPGFIARMRPVVQ 116 AA ++ F + I +GP H RRLL++ + RP +Q Sbjct 62 RNLDRKGAARMATTEDGGTFSRPSQGDADIKEGPGHRRWRRLLSRAFTVKKMEAWRPRIQ 121 Query 117 QIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIG 176 ++ D +D + A P D + V++P+ +++ LLG + A + +++ Sbjct 122 EMADELVDAMVAKGSPADLRAAVALPLPVRVICALLGAPSEDQDTFARWSETLLTLTRYT 181 Query 177 DEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQ-ANRQQSTMTDEQVVGMLLTVVIG 235 EV + D++ RK A PGDDLLS + Q + + ++ ++++ ++ +++ Sbjct 182 QAEVDDAQAEFRAYASDLVERKRARPGDDLLSELTQITDSEDGRLSHDELIATVVGLLLA 241 Query 236 GVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVV 295 G +T +I A LL R++YE L+ DPG V VEE +R +P + R +TED Sbjct 242 GHETTSNMILKMTAMLLSERERYETLLADPGLVPGVVEEALRLDPLGGVGIPRFITEDTE 301 Query 296 IAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVER-NPNEHIAFGYGPHACPASAYSRM 354 ++G + AGS F ++ +ANRD +F DPD FD R N +H+AFG GPH C +R+ Sbjct 302 VSGVPVGAGSTLFVNLHAANRDERKFPDPDRFDPRRENSAQHVAFGAGPHFCVGQTLARV 361 Query 355 CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 L + + P+L+L EDL R +G+ + G ++L VTW Sbjct 362 ELQVCLATFVRHLPELRLRDAPEDLRMR-EGISAGGFEDLWVTW 404 >gi|120431554|gb|ABM21740.1| PdmW [Actinomadura hibisca] Length=401 Score = 211 bits (537), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 135/401 (34%), Positives = 210/401 (53%), Gaps = 7/401 (1%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 M +T +P +PF RP EP L LR PV + LPSG AW+VTR+ DV+ +L+D R Sbjct 1 METTPLP-YPFRRPSALEPPAELRGLREQ-PVVKVVLPSGDEAWMVTRYADVRALLADDR 58 Query 61 FSCRAAAHPSSPPFVPFVQLCPS-LLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIV 119 S R P + +L + D P+HT RRL+ + L P + R+RP VQ+I Sbjct 59 IS-RNLNRPGAARISAKNKLFQDPKMDPDPPEHTRIRRLVMKALTPSRVERLRPRVQEIT 117 Query 120 DNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEE 179 D + +A PP+D E ++ P+ Q++ +LLGV + A +S+ +E Sbjct 118 DRLVTAMAERRPPIDVNEALAYPLPIQVVCELLGVPVEDQERFRVWTGAFLSISGYTQDE 177 Query 180 VSRRWSALCTMVIDILHRKLAEPGDDLLST-IAQANRQQSTMTDEQVVGMLLTVVIGGVD 238 + R S L + D++ K A+P DDL+S IA + + +++ ++ +V+ G + Sbjct 178 IERNMSRLNEYMRDLIEAKRADPADDLISAMIAVTDAEDGRLSEYELHWWSRLLVLVGFE 237 Query 239 TPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFN-PATEIEHLRVVTEDVVIA 297 T I +A LL DQ + + +DP + AVEE++R+ + + LR VTEDV + Sbjct 238 TTAVQIGGCIAMLLSRPDQLDLVRKDPALLRPAVEELLRWKIVGSSVTMLRYVTEDVEVG 297 Query 298 GTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLT 357 G + AGS + SAN+D F P+ FDV R N H+ F +G H C ++ +R+ L Sbjct 298 GVTIPAGSSIIPAGDSANQDESVFEHPEVFDVTRTDNPHLTFSHGTHYCAGASLARLELE 357 Query 358 TFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 ++L +R P L+LA P DL RR G +E+ +TW Sbjct 358 VVLSTLIRRLPDLRLAIPATDL-RRNDGNLLESFREIPITW 397 >gi|300785817|ref|YP_003766108.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|299795331|gb|ADJ45706.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|340527281|gb|AEK42486.1| cytochrome P450 [Amycolatopsis mediterranei S699] Length=419 Score = 209 bits (533), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 136/402 (34%), Positives = 208/402 (52%), Gaps = 11/402 (2%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 M + +P +PF V + P +ELR S + +P G AWLVTR++ + VLSD R Sbjct 25 MDAQPVP-YPFGDAVALQAHPRFAELRKSAAPVRVTMPYGGDAWLVTRYEQTRFVLSDPR 83 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FS AAA P P + +LL++D P+H R L+A+ + +RP +Q+IVD Sbjct 84 FSRAAAAGADVPRGRPGFEPAGNLLAMDPPEHNRVRALVAKAFTGRRVELLRPRIQEIVD 143 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPK---TVHELAAHVDAAMSVCEIGD 177 LD + PP DF V+ + ++ +LLGV P V E + A+ D Sbjct 144 TLLDGI---RPPADFASAVAWELPVLVIGELLGVPPGELPMVRECTETLVASGGTVTPAD 200 Query 178 EEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGV 237 +R L + ++ R+ EP DDLL+ +A A ++ +TD++++ + + ++ GG Sbjct 201 VTEAR--GKLAGALKTLIARRREEPADDLLTALAAARDEEDRLTDDELLMLGVALLAGGH 258 Query 238 DTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVI 296 ++ + + L LL R+++ LV P V AVEE++RF P AT + R+ ED+ I Sbjct 259 ESTANLTGSILVELLSDRERWTALVARPELVPSAVEELLRFVPLATVADFARIAREDLEI 318 Query 297 AGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCL 356 G A+ AG + SANRD F E D R N H+AFG+G H C + +R+ L Sbjct 319 GGQAIRAGDAVLVQLDSANRDESVFPSAGEMDFGRKVNHHVAFGFGVHHCVGAPLARLEL 378 Query 357 TTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 ++L +R P L+LA ED+E R GL G+ L VTW Sbjct 379 RVLLSTLVRRRPDLRLAISPEDIEWRRGGLLR-GVSSLPVTW 419 >gi|256378615|ref|YP_003102275.1| cytochrome P450 [Actinosynnema mirum DSM 43827] gi|47078304|gb|AAT09797.1| NocL [Nocardia uniformis subsp. tsuyamanensis] gi|255922918|gb|ACU38429.1| cytochrome P450 [Actinosynnema mirum DSM 43827] Length=398 Score = 209 bits (532), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 135/400 (34%), Positives = 204/400 (51%), Gaps = 4/400 (1%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MT T ++PF PV + P + LR P + LP G WLVTR +DVK VLSD R Sbjct 1 MTRTDTRSYPFGDPVALDLHPGYAPLRAEQPALRVRLPYGEDCWLVTRHEDVKAVLSDSR 60 Query 61 FS-CRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIV 119 FS RAA +P P S+LS+D P+H+ R+L+A+ + RP Q+IV Sbjct 61 FSRARAAGREETPRVTPEAAPAGSMLSMDPPEHSRLRKLIARAFTSRRVREFRPRTQEIV 120 Query 120 DNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEE 179 D LD + A P D +++P+ +++++LGV + + +S EE Sbjct 121 DGLLDQVEQAGAPADLVAGLALPLPVSVISQMLGVPTEDHYRFRDFSATVLSTTAHTREE 180 Query 180 VSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDT 239 + +AL + ++ ++ EPG+DL+S + A+ +TD ++ +T+++GG ++ Sbjct 181 IVAARAALEEYLGELADQRRREPGEDLMSALVAAH-DDDRLTDRELTQTGITLLVGGHES 239 Query 240 PIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVIAG 298 + + LL +++ L ++P V AVEE++RF P + R+ TEDV + G Sbjct 240 TASQFACSVYLLLERPERWALLRDNPELVPTAVEELLRFIPLGSGGAFARIATEDVEVGG 299 Query 299 TALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTT 358 + AG S SANRD F DPD D+ R N H+AFG G H C + +R L Sbjct 300 VLVRAGEAVVASTNSANRDDRVFTDPDVLDLAREHNPHLAFGGGVHVCLGAQLARGELQV 359 Query 359 FFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 TSL RFP L+LA P E + R L + EL VTW Sbjct 360 ALTSLLTRFPGLRLAVPPEQVPWRQGSLLRSPV-ELPVTW 398 >gi|157384619|gb|ABV49597.1| cytochrome P450 [Streptomyces eurythermus] Length=415 Score = 208 bits (529), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 133/393 (34%), Positives = 197/393 (51%), Gaps = 7/393 (1%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +PF P+ LR PVA + +P G AW+VTR D K VL D RFS A A Sbjct 27 YPFSTATGLGMDPLYGYLREREPVARVRMPYGGEAWMVTRHADAKLVLGDPRFSMAAGAG 86 Query 69 PSSPPFVPFVQLCP--SLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDL 126 P P QL L+++D P+HT RRL + RMRP V + +D + Sbjct 87 KDVPR--PTEQLLEPGGLVAMDPPEHTRLRRLAGGVFTHRRVERMRPSVTALAHRLVDGM 144 Query 127 AAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSA 186 +AA D E V++P+ ++ +LLGV+ + H DA +S + EEV R Sbjct 145 SAAGSSADLLEAVALPVSIGVICELLGVDYEDRHVFQRFSDALLSTA-LPPEEVRRAGEE 203 Query 187 LCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITN 246 + ++ + P DDLL + QA + +++ ++ + +++GG +T I N Sbjct 204 FVGYLARLVAERRESPTDDLLGAMVQARDDEDRLSENELYMLGAGLLVGGYETTATQIGN 263 Query 247 GLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIE-HLRVVTEDVVIAGTALSAGS 305 LL R Y LVEDPG + AVEE++RF P T ++ + R+ EDV++ GT + AG Sbjct 264 FAYLLLRDRRLYASLVEDPGLIQGAVEELLRFTPLTTVDGYARIALEDVMVGGTLIRAGE 323 Query 306 PAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQ 365 FTS+ +AN D + F P+ D R N H+ FG+G H C + +R+ + LT+ Sbjct 324 AVFTSVAAANLDPEVFPGPERLDFTRERNPHLGFGHGIHYCMGAPLARLEIQVVLEVLTR 383 Query 366 RFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 R P L+LA P D+ R GL + L VTW Sbjct 384 RLPGLRLAVPAADV-RWQPGLLLRVPERLPVTW 415 >gi|311900397|dbj|BAJ32805.1| putative cytochrome P450 [Kitasatospora setae KM-6054] Length=409 Score = 207 bits (526), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 129/388 (34%), Positives = 199/388 (52%), Gaps = 11/388 (2%) Query 16 PTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPSSPPF- 74 P +P+ L+ELR PVA + P GHT WLVT +D+V+ +L+++R S R S P Sbjct 28 PFDPAVGLAELRAEHPVARMVFPDGHTGWLVTGYDEVRRLLTERRMSSRGEILRSPIPLP 87 Query 75 --VPFVQLCPSLLS-IDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAAAEP 131 + + P + + +D P+HT RR +A + + P + ++VD LD + A E Sbjct 88 MASSGMAIPPGMFTAMDPPEHTRYRRQVASWFSARRTRTLEPWMTELVDRHLDAMLAHEG 147 Query 132 PVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSALCTMV 191 PVD E + P+ + +LLGV E V A +V +E +S W + ++ Sbjct 148 PVDLVEAFAEPVAVAAICELLGVPTDQREEFGKAVQALFTVHSSAEEAISG-WQNIGAVL 206 Query 192 IDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLASL 251 ++ K AEP DD+L T+A ++DE++ + +++ G DT + +I G +L Sbjct 207 ARLVRTKRAEPADDMLGTLAAGG----DLSDEELATIGSVLLVAGYDTSLNMIGLGTFAL 262 Query 252 LHHRDQYERLVEDP-GRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTS 310 L H QY L DP G +AVEE++R+ +R ED+ G ++AG S Sbjct 263 LEHPQQYAALAADPEGLAPKAVEELLRYLTVVHGGAIRAAGEDLEFDGHRMAAGDAVSMS 322 Query 311 ITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQL 370 + +ANRD DPD D+ R P H+AFGYG H C ++R+ L F L R P+L Sbjct 323 LAAANRDPALCADPDRLDITREPVPHLAFGYGIHQCVGQQFARLELRIAFERLAARLPEL 382 Query 371 QLARPFEDLERRGKGLHSVGIKELLVTW 398 +LA P E + R + + G+ EL VTW Sbjct 383 RLAVPAEQVRTRAE-MIIYGVHELPVTW 409 >gi|159038783|ref|YP_001538036.1| cytochrome P450 [Salinispora arenicola CNS-205] gi|157917618|gb|ABV99045.1| cytochrome P450 [Salinispora arenicola CNS-205] Length=415 Score = 207 bits (526), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 139/398 (35%), Positives = 203/398 (52%), Gaps = 14/398 (3%) Query 8 TFP-FDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAA 66 TFP F+R P +P +EL CPVAP+ + G +WL+T F+ V+ LSD RFS Sbjct 25 TFPQFERSTPFDPPQAYTELSGRCPVAPVSMADGKPSWLITSFEGVRTTLSDPRFSS-DM 83 Query 67 AHPSSPPFV--PFVQLCPSLL-SIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNAL 123 +HP P P L L ++DG +H RR+L L MRPV+ QI D AL Sbjct 84 SHPGFPNRTGKPVDDLLKDTLGAMDGERHRYYRRMLTGELTVRRAKAMRPVITQITDEAL 143 Query 124 DDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEE---V 180 D LAAA P D + V+ + ++ L+G+ P + +EL + A + D++ + Sbjct 144 DQLAAAGPGADLVKHVAFVVPSRVACHLVGI-PLSDYELFTGMAATLMDSTSSDDQFAAL 202 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 S T+V D H DDLL + + +T + ++ + T + G +T Sbjct 203 QNMVSYFDTLVTDREHHD----RDDLLGHMVRRYLATGELTRDMLIRLAWTTMAAGQETT 258 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 +I G+A+LL H DQ E L +P + AV+E++R+ P + RV +DV + G Sbjct 259 AHMIGLGVAALLRHPDQLELLRREPHLLPGAVDELMRYLPLIQFGIPRVAMDDVEVDGQT 318 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 ++AG ANRD F PDE DV RN +H+ FGYGPH CPA A +R+ L + Sbjct 319 VTAGEGVVALPPLANRDPAVFERPDELDVRRNARQHLTFGYGPHQCPAHALARLELEVVY 378 Query 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 L +RFP L+LA DL+ + K + + EL VTW Sbjct 379 GRLLERFPTLRLADSDADLKVQDKDI-MYRVSELAVTW 415 >gi|134098012|ref|YP_001103673.1| cytochrome P450-like enzyme [Saccharopolyspora erythraea NRRL 2338] gi|291007223|ref|ZP_06565196.1| cytochrome P450-like enzyme [Saccharopolyspora erythraea NRRL 2338] gi|133910635|emb|CAM00748.1| cytochrome P450-like enzyme [Saccharopolyspora erythraea NRRL 2338] Length=398 Score = 206 bits (525), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 124/391 (32%), Positives = 197/391 (51%), Gaps = 3/391 (0%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +PF P + LR P++ ++LP G AWL TR++D K VL+D RFS A Sbjct 7 YPFSAAERLNLDPFYARLRAQEPMSRVKLPYGEAAWLATRYEDAKVVLADPRFSRAAVLE 66 Query 69 PSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAA 128 P P + +LS+D P HT RRL+A+ + R+RP Q+I D +D + Sbjct 67 KDEPRMRPGIT-GGGILSMDPPDHTRLRRLVAKAFTQRRVERLRPRTQEIADGLVDRMIE 125 Query 129 AEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSALC 188 P D E ++P+ ++ +LLGV + + DA +S ++ E+V + Sbjct 126 HGSPADLVEEFALPLPITVICELLGVPYEDRDDFREWSDAFLSTTKLTPEQVVDYMDRMF 185 Query 189 TMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGL 248 + ++ ++ +P DDL+S + +A + +T++++V + +++ G +T I N + Sbjct 186 GYMAGLIAKRRVDPQDDLMSALIEARDEHDKLTEQEMVQLAAGILVAGHETTATQIPNFV 245 Query 249 ASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVIAGTALSAGSPA 307 LL H DQ E L+ D + RAVEE+ R+ P R EDV + G + AG P Sbjct 246 YVLLTHPDQLEGLLADLDGLPRAVEELTRYVPLGVAAVFARYAVEDVELGGVTVRAGEPV 305 Query 308 FTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQRF 367 S +SANRD F DPD D+ R N HI FG+GPH C + +R+ L +L R Sbjct 306 LVSASSANRDEAVFDDPDRLDLTRENNAHIGFGHGPHHCLGAQLARLELQVGLRTLLTRL 365 Query 368 PQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 P L+ A +D+ + +G+ G +L V W Sbjct 366 PGLRFAGGEDDVVWK-EGMLVRGPSKLEVAW 395 >gi|26541527|gb|AAN85514.1|AF484556_36 cytochrome P450 hydroxylase [Streptomyces atroolivaceus] Length=399 Score = 206 bits (525), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 126/401 (32%), Positives = 205/401 (52%), Gaps = 5/401 (1%) Query 1 MTSTS-IPTFPFDRPVPT-EPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSD 58 M++T + +PF+ V E P +ELR + P+A + LP G W+VTR+DDV+ SD Sbjct 1 MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGEGWMVTRYDDVRAANSD 60 Query 59 KRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQI 118 RFS RA +P P + ++LS+D P+HT RRLL++ + M+ ++++ Sbjct 61 PRFS-RAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEEL 119 Query 119 VDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDE 178 LD + P D ++ P ++ +LLGV + + MS E Sbjct 120 FAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSKE 179 Query 179 EVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVD 238 E +++ + D++ + A P DDLL + A +T+++++ +T+++ G + Sbjct 180 EAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAGHE 239 Query 239 TPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVIA 297 T + N + +LL H DQ L E P + RAVEE++RF P + + R+ EDV ++ Sbjct 240 TSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEELLRFVPLGNGVGNARIALEDVELS 299 Query 298 GTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLT 357 G + AG + +ANRD F DPD D+ R N H+AFG+G H C + +RM L Sbjct 300 GGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKNPHLAFGHGAHYCLGAQLARMELR 359 Query 358 TFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 L +RFP L+LA P + +E + GL G + L + W Sbjct 360 VAIGGLLERFPGLRLAVPADQVEWKTGGLFR-GPQRLPIAW 399 >gi|324997918|ref|ZP_08119030.1| cytochrome P450 hydroxylase [Pseudonocardia sp. P1] Length=419 Score = 205 bits (522), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 135/397 (35%), Positives = 203/397 (52%), Gaps = 10/397 (2%) Query 8 TFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAA 67 ++P E P +ELR P+A I +P G L TR+DDV+ V+SD RFS A Sbjct 27 SYPLGEAHELEFDPGYAELRREEPLARIRMPYGEEGRLATRYDDVRTVMSDPRFSRAAVV 86 Query 68 HPSSPPFVPFVQLCP-SLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDL 126 P +P P S+++ID P+H RRL+A + RMRP V I D+ +D L Sbjct 87 GADVPRALPERPGQPESIINIDPPEHGRLRRLVAAAFTARRVERMRPHVAGIADDLVDGL 146 Query 127 AAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSA 186 A P D VS+P ++ +LLGV A DAA+S + EE + + Sbjct 147 VAGGSPADLVSAVSMPFPVIVICELLGVPLDGRDTFRAAADAALSTSAVPVEERRQAMTD 206 Query 187 LCTMVIDILHRKLAEP---GDDLLSTIAQA-NRQQSTMTDEQVVGMLLTVVIGGVDTPIA 242 L T + ++ + P GDD+L + A + +++ ++V + +++ G +T + Sbjct 207 LHTYIASLVAERRDRPDGPGDDVLGGLVSARDDDGDRLSEGEMVSLGSAILLAGHETTMN 266 Query 243 VITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTAL 301 + N + +LLH R +++ LV +P + AVEE++RF P L R+ T DV + G + Sbjct 267 MTGNMVRTLLHERSRWDALVAEPDGIPAAVEEMLRFIPLGRQAGLPRIATADVELTGGTV 326 Query 302 SAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFT 361 AG S +ANRD + F DPD ++R+P H+AFGYGPH C ++ +RM L T Sbjct 327 RAGEAVLVSTNAANRDPEVFDDPDALHLDRSPGAHVAFGYGPHHCLGASLARMELQTILR 386 Query 362 SLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 +LT R P L LA +D+E R G L VTW Sbjct 387 ALTTRLPGLDLA---DDVEWRATSAVR-GPARLPVTW 419 >gi|256375333|ref|YP_003098993.1| cytochrome P450 [Actinosynnema mirum DSM 43827] gi|255919636|gb|ACU35147.1| cytochrome P450 [Actinosynnema mirum DSM 43827] Length=394 Score = 205 bits (521), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 136/396 (35%), Positives = 201/396 (51%), Gaps = 7/396 (1%) Query 6 IPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRA 65 + +PF+ V P P EL+ PV+ + LP G AWLVTR DVK VL D RFS A Sbjct 3 VRNYPFNEAVELRPDPTALELQEREPVSQVRLPYGGDAWLVTRHADVKTVLGDPRFSRAA 62 Query 66 AAHPSS--PPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNAL 123 + P P + ++L++D P HT R+L+A+G +R Q+IVD+ L Sbjct 63 TLELGADLPRAFPLHRTESNILTMDPPDHTRLRKLVAKGFTARRTELLRARAQEIVDDLL 122 Query 124 DDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRR 183 D + PP D E +++P+ ++ ++LGV A DAAMS+ EEV Sbjct 123 DAMEEQGPPADVVEALALPLPITIICEMLGVPVADRDRFRAWSDAAMSITAFTPEEVLAA 182 Query 184 WSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAV 243 +L + ++ K A PGDD+L+ + A+ +T +VV +T++ G +T Sbjct 183 ARSLREYIAGLVEDKRANPGDDVLTDLVTAHDGGGPLTATEVVTFGVTLLAAGHETTANQ 242 Query 244 ITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVIAGTALS 302 I N +LL + D+ L DP V RAVEE++RF P R+ TEDV ++G + Sbjct 243 IANFTHTLLANPDRMAELRADPALVPRAVEELLRFTPLGGSAGFPRIATEDVELSGVTVP 302 Query 303 AGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTS 362 G+ F I S NRD + F P E D R N H+AFG+G H C + +R+ L + Sbjct 303 RGAAVFVDIPSGNRDPEVFERPHEIDFHRAANPHVAFGHGVHHCVGAQLARVELQVAVGT 362 Query 363 LTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 L RFP L+ A E + +RG+ + G + L V W Sbjct 363 LLARFPGLEPAG--EAVFKRGRLVR--GPQSLPVRW 394 >gi|45124720|emb|CAE53710.1| putative cytochrome P450 [Streptomyces peucetius ATCC 27952] Length=405 Score = 204 bits (520), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 129/398 (33%), Positives = 204/398 (52%), Gaps = 15/398 (3%) Query 9 FPFDRP--VPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAA 66 FP RP P +P +E R CPV P+ P GH LVT + VL D RFS A Sbjct 15 FPTARPSGCPFDPPAPFAEAREECPVTPLRYPDGHLGRLVTGLQSARAVLGDVRFSSLPA 74 Query 67 AHPSSPPFVPFVQLCPSLL------SIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 SP VP +L L ++D P+HT RRLL++ + +RP +Q++ D Sbjct 75 GK-RSPVKVPGSELSTDALPAGMFVNMDPPEHTRYRRLLSKHFTLRRVRELRPRIQEMTD 133 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 LDD ++ PVD + P+ + ++LLG+ + HVD S+ G EE+ Sbjct 134 RLLDDTESSGGPVDLVAAFAKPLPMLVTSELLGLPEEDRAPFGHHVDVLFSLSSSG-EEM 192 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 + L M+ +++ +PG D+L + ++ +TDE+++G+ ++I G++T Sbjct 193 QQSMVLLAGMLHALINAARKDPGPDILGRLTV----ETELTDEELLGITTVLLIAGLETT 248 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 ++ G +LL H +Q L D + AVEE++R+ +I +RV ED G + Sbjct 249 THMLALGTYALLRHPEQLAALRADWSLMDDAVEELLRYLSVVQIGPIRVAAEDFEFEGQS 308 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 + G S+ +ANRD F DPD FD+ R H+AFG GPH C +R+ L+ + Sbjct 309 IRKGEVVTVSLPAANRDPQGFEDPDTFDIRRGAARHVAFGSGPHQCMGHHLARLELSIGY 368 Query 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 SL +RFP+L+LA P +++ R + + + G+ EL V W Sbjct 369 ESLLRRFPRLELAVPAQEIGTR-EMMVTYGVPELPVRW 405 >gi|329941121|ref|ZP_08290400.1| cytochrome P450 hydroxylase [Streptomyces griseoaurantiacus M045] gi|329299652|gb|EGG43551.1| cytochrome P450 hydroxylase [Streptomyces griseoaurantiacus M045] Length=399 Score = 203 bits (517), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 138/405 (35%), Positives = 202/405 (50%), Gaps = 14/405 (3%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MT+ + P R P +P P L+ELR P++ + P GH WLVT D + VL+D R Sbjct 1 MTTHDAVSLPTLRATPFDPPPALAELRARSPLSRLRYPDGHLGWLVTGHDLARKVLADPR 60 Query 61 FSCRA------AAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 114 FS R+ A S PF L L+ +D PQHT RR LA+ + +RP Sbjct 61 FSARSEWKRNPVARRSLEPFYGAKALPGWLVDMDPPQHTRIRRRLARAFTAHRMRTLRPR 120 Query 115 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCE 174 ++QIV L +A A P+D ++P+ ++ +LLGV P + A + + Sbjct 121 IEQIVSRQLTAMAEAGDPLDLVAAFALPVPSLVICELLGV-PYSRRADFQRDSATLFSLD 179 Query 175 IGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 234 E+ +R L T + ++ K PG+DLL T+A ++ ++ G ++ Sbjct 180 ATAEQAARAMDDLQTFLTELAAHKSRRPGEDLLGTLAS----DGELSVAEIAGAGALLLS 235 Query 235 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV 294 G +T + G+ +LL H DQ RLVEDPG AVEE++R+ + R EDV Sbjct 236 AGHETTAGSLGLGVLALLSHPDQLARLVEDPGLADTAVEELLRYLTIFQFGVPRSALEDV 295 Query 295 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM 354 +AG L AG S+ +ANRD +F DPD DV RN + H+AFG+G H C +R Sbjct 296 PLAGETLRAGESVTVSLPAANRDPLRFPDPDRLDVGRNASGHLAFGHGMHQCIGQNLART 355 Query 355 CLTTFFTSLTQRFPQLQLARPFEDLERRGK-GLHSVGIKELLVTW 398 + F +L RFP+L+LA P + L G G + V L V+W Sbjct 356 EMRIAFPALFGRFPRLRLAVPAQRLSFGGDTGFYCV--HRLPVSW 398 >gi|112791729|gb|ABI22127.1| cytochrome P450 hydroxylase [Streptomyces lavendulae] Length=395 Score = 203 bits (516), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 128/398 (33%), Positives = 198/398 (50%), Gaps = 3/398 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MT+T P++PF E + L+ LR P++ + +P G AWLVTR DVK VL+D R Sbjct 1 MTTTPAPSYPFPAKYLDEAAE-LARLRQEEPISRVTMPYGGEAWLVTRMADVKEVLADPR 59 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FS + P F P + + +D P+ T RRL+A+ + P VQ IVD Sbjct 60 FSRQLQTEADRPRFFP-EPVVEGIGIMDPPEQTRLRRLVAKAFTARRVQEFGPRVQTIVD 118 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 LD + A P D S + + + +GV + D+ +S +E+ Sbjct 119 ELLDAVEAKGAPADLYADFSWQLPGISICEFMGVPYEDRDRFVPFFDSVVSTTSKTPDEI 178 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 + L +++ R+ A PGDDL + + +A + +++++++ M +++ G++T Sbjct 179 RQAIGDLHAYFGELIERRRATPGDDLFTALIRARDEDDRLSEKELIEMSFGLLVAGMETT 238 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 + + N L L + DQ E L P V AVEE++RF P ++ V EDV + G Sbjct 239 ASQLANFLYLLFRNPDQLELLRAKPELVPNAVEELLRFVPLLAVDQPSVAREDVTLGGVL 298 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 + AG S+ SANRD+D F +P DV R N H+AF +G H C + +RM + T Sbjct 299 IRAGETVVPSMNSANRDADVFENPQRIDVTRENNPHLAFSHGAHHCVGAQLARMEMVTAL 358 Query 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 SL RFP L A P E+L R G+ G++ L V W Sbjct 359 RSLLVRFPGLHQAVPDEEL-RWKAGVVLRGVEALPVAW 395 >gi|294146926|ref|YP_003559592.1| putative cytochrome P450 [Sphingobium japonicum UT26S] gi|292677343|dbj|BAI98860.1| putative cytochrome P450 [Sphingobium japonicum UT26S] Length=410 Score = 203 bits (516), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 124/379 (33%), Positives = 196/379 (52%), Gaps = 21/379 (5%) Query 8 TFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAA 67 TFP++R +P P + LR PV + L G AWLVTR++DV+ +L+D R S Sbjct 16 TFPWERGT-YDPPPAYAWLREHEPVRRVVLHDGTPAWLVTRYNDVRSILADPRVSSN--- 71 Query 68 HPSSPPFVPFVQLCP-------SLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 + P P ++L P + L++D P+HT RRL+++ + MRP +Q +VD Sbjct 72 --QNLPGFPQIELVPRPSEEESTFLNMDAPRHTLFRRLISKHFIVKKLEVMRPRIQALVD 129 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 +D + P DF E +++P+ ++A LLGV P H A+ +G EE Sbjct 130 EHIDHIIDRSEPFDFVEEIALPVPSTVIAWLLGVPPSD-HPFFNRETEALLAASLGTEEA 188 Query 181 SRRWSALCTMVIDILHR------KLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVI 234 R + + D + R KL +PGDD+L + +A+R+ + V+ +++ Sbjct 189 IERATEAYANINDYVDRLIAEREKLDDPGDDILGDLVRASRE-GQIERRDVLNTAWLLLV 247 Query 235 GGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDV 294 G DT +I G+ +LL H DQ +L +P + A+EE++R+ + LR+ TED+ Sbjct 248 AGHDTTANMIGLGMLTLLEHPDQLAQLQAEPALIPDAIEELLRYLTVVHLIILRIATEDI 307 Query 295 VIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM 354 I G + AG +ANRD F D +FD+ R P +H+AFGYG H C A +R+ Sbjct 308 EIGGVTIPAGEGIIPLNFAANRDDGHFPDAAKFDIRRRPRDHVAFGYGVHQCIGQALARI 367 Query 355 CLTTFFTSLTQRFPQLQLA 373 L F +L +R P ++LA Sbjct 368 ELQIVFETLLRRIPNVRLA 386 >gi|80279143|gb|ABB52528.1| cytochrome P-450 [Streptomyces sp. KCTC 0041BP] Length=407 Score = 202 bits (515), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 127/380 (34%), Positives = 187/380 (50%), Gaps = 3/380 (0%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +PF P P+ S LR PV+ I +P G AWL+TR DVK VL D RFS A A Sbjct 13 YPFSLPEGIALDPLYSHLREHEPVSRIRMPYGGEAWLLTRHADVKAVLGDPRFSMEAGAG 72 Query 69 PSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAA 128 P + L+S+D P HT RRL + + +RP V + LD + A Sbjct 73 RDVPRPTEYPLPAGGLISMDPPGHTRLRRLAGKAFTARRVEELRPQVSRFTHELLDGMVA 132 Query 129 A-EPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSAL 187 EP + E +++P+ ++ +LLGV H L + A+ +G E+ R Sbjct 133 RDEPSGEIMEDLALPVSISVICRLLGVSYDDRH-LFRNFSEALVSSSLGPAELQRVTEGF 191 Query 188 CTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNG 247 + +++ + A P DD LST+ QA + +++ +++ + ++I G +T I N Sbjct 192 TAYMAELVADRRARPTDDFLSTMVQARDEDDRLSEAELLMLGAGLLISGYETTATQIGNF 251 Query 248 LASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTALSAGSP 306 + LL R YERLV DP V AVEE++RF P + + R+ EDV I GT + AG Sbjct 252 VHLLLDDRRLYERLVADPDLVPAAVEELLRFTPLSTTDGFARIALEDVEIGGTLIRAGEA 311 Query 307 AFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQR 366 TSI SAN D F D R N H+ FG+G H C + +R+ L ++L +R Sbjct 312 VITSIASANLDGTAFPGAASLDFTRAQNPHLGFGHGAHYCMGAPLARLELQVVLSTLVER 371 Query 367 FPQLQLARPFEDLERRGKGL 386 P L+L+ P +L R L Sbjct 372 LPGLRLSVPASELRWRTGSL 391 >gi|254385127|ref|ZP_05000460.1| cytochrome P-450 [Streptomyces sp. Mg1] gi|194344005|gb|EDX24971.1| cytochrome P-450 [Streptomyces sp. Mg1] Length=407 Score = 202 bits (514), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 127/380 (34%), Positives = 188/380 (50%), Gaps = 3/380 (0%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +PF P P+ S LR PV+ I +P G AWL+TR DVK VL D RFS A A Sbjct 13 YPFSLPEGIALDPLYSHLREHEPVSRIRMPYGGEAWLLTRHADVKAVLGDPRFSMEAGAG 72 Query 69 PSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAA 128 P + L+S+D P HT RRL + + +RP V + LD + A Sbjct 73 RDVPRPTEYPLPAGGLISMDPPGHTRLRRLAGKAFTARRVEELRPQVSRFTHELLDGMVA 132 Query 129 A-EPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSAL 187 EP + E +++P+ ++ +LLGV + H L + A+ +G E+ R Sbjct 133 RDEPSGEIMEDLALPVSISVICRLLGVSYEDRH-LFRNFSEALVSSSLGPAELQRVTEDF 191 Query 188 CTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNG 247 + +++ + A P DD LST+ QA + +++ +++ + ++I G +T I N Sbjct 192 TAYMAELVADRRARPTDDFLSTMVQARDEDDRLSEAELLMLGAGLLISGYETTATQIGNF 251 Query 248 LASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTALSAGSP 306 + LL R YERLV DP V AVEE++RF P + + R+ EDV I GT + AG Sbjct 252 VHLLLDDRRLYERLVADPDLVPAAVEELLRFTPLSTTDGFARIALEDVEIGGTLIRAGEA 311 Query 307 AFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQR 366 TSI SAN D F D R N H+ FG+G H C + +R+ L ++L +R Sbjct 312 VITSIASANLDDTAFPGAASLDFTRAQNPHLGFGHGAHYCMGAPLARLELQVVLSTLVER 371 Query 367 FPQLQLARPFEDLERRGKGL 386 P L+L+ P +L R L Sbjct 372 LPGLRLSVPASELRWRTGSL 391 >gi|337763118|emb|CCB71826.1| Cytochrome P450-SU2 [Streptomyces cattleya NRRL 8057] Length=406 Score = 202 bits (513), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 134/400 (34%), Positives = 203/400 (51%), Gaps = 12/400 (3%) Query 7 PTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAA 66 P P R P +P+P + LR PV+ I P G T WLVTR+ DV+ +L+D RFS R Sbjct 11 PGMPRVRRCPYDPAPEYARLREEAPVSRISFPGGGTGWLVTRYQDVRAMLADPRFSSRQG 70 Query 67 AHPSSPPFVPFVQLCP-----SLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDN 121 ++P P P +LL +D P+H RR + + + R+RP +Q+I D+ Sbjct 71 T--TAPQVRPVPAALPEPPPGALLRLDEPEHRTYRRPVMRAFTVKQVTRLRPRIQRITDD 128 Query 122 ALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVS 181 LD + PVD +++P+ ++ +LLGV ++V +I E+ + Sbjct 129 HLDAMERDGGPVDLVAALALPVTSLVICELLGVSYADRGAFQGLAGRLLAV-DISPEQSA 187 Query 182 RRWSALCTMVIDILHRKLAEPGDDLLST-IAQANRQ-QSTMTDEQVVGMLLTVVIGGVDT 239 + +AL + D++ K +PGDDL+S IA+A+ S +TD + + ++I G +T Sbjct 188 QDRAALAAFMTDLVAAKRRDPGDDLISALIAEADADPDSPLTDHALTILGALLLIAGHET 247 Query 240 PIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGT 299 +I+ G +LL H DQ P RAVEE++R+ + RV TE+V + G Sbjct 248 TANMISLGALTLLDHPDQLAAWRARPELADRAVEELLRYLTIIQFGLARVATEEVTLGGR 307 Query 300 ALSAGSPAFTSITSANRDSDQFL-DPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTT 358 + AG ++ SANRD L DPD D+ R+P H+AFG+GPH C +R L Sbjct 308 TIRAGEMVVAALPSANRDPLMGLADPDRLDITRSPAPHLAFGFGPHQCLGQQLARAELQI 367 Query 359 FFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 SL RFP L+ A P +L R + G+ L VTW Sbjct 368 TLGSLFARFPTLRTAVPTAELPFR-DDMIIYGLHALPVTW 406 >gi|112419474|dbj|BAF02929.1| cytochrome P450 monooxygenase [Streptomyces halstedii] Length=414 Score = 202 bits (513), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 133/401 (34%), Positives = 202/401 (51%), Gaps = 16/401 (3%) Query 7 PTFPFDRP----VPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFS 62 P FPF + TE P+L+ R+ +A + +P G AW+ TR DVK VLSD R S Sbjct 21 PDFPFADENGIQLGTEYDPLLA--RDG--LARVTMPHGGDAWIATRMADVKKVLSDPRLS 76 Query 63 CRAAAHPSSPPFVPFVQLCPS---LLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIV 119 AAA P SP + P ++ PS L+ +DGP+H RRLL + L+ G + MRP +++ V Sbjct 77 RTAAARPDSPRYTP--EVLPSGGVLVGLDGPEHARIRRLLGKALSVGLMEGMRPWIRETV 134 Query 120 DNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEE 179 D L DL PPVD + + + KLLG+ H VD +S+ +E Sbjct 135 DEILTDLLDQGPPVDLVRELGEKLPRLAICKLLGMPYSDRHRFDESVDVVVSMATRSRDE 194 Query 180 VSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDT 239 V R WS L + +++ K EP +DL+S + + + +D +V+ + V++ G ++ Sbjct 195 VGRAWSTLSAYIGELVEAKRREPAEDLISALLEVRHDGDSFSDREVITNTIAVLVAGYES 254 Query 240 PIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRV-VTEDVVIAG 298 + +T L+ H + L EDP R+ +VEE++R+ + + TEDV I Sbjct 255 TASELTTMAYLLMVHPGLKDSLREDPSRIPASVEEMLRYAALSPAGAMTCRATEDVTIGE 314 Query 299 TALSAGSPAFTSITSANRDSDQFLDPDEFDVER-NPNEHIAFGYGPHACPASAYSRMCLT 357 T + G + +AN D F P E D +R N +H+AFG+G H C + +R+ L Sbjct 315 TEVREGDAVVPCLVAANYDQTVFDQPRELDPDRGNKGKHLAFGFGAHYCMGARLARIELQ 374 Query 358 TFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 T L R P L+LA + L RR + + G L VTW Sbjct 375 EALTGLVHRMPGLRLAVSEKLLPRRTE-MGMRGFLRLPVTW 414 >gi|35186977|gb|AAQ84152.1| PlmT4 [Streptomyces sp. HK803] Length=403 Score = 202 bits (513), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 130/406 (33%), Positives = 204/406 (51%), Gaps = 17/406 (4%) Query 3 STSIPTFPFDRP--VPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 S+ +P FP + P +P P ++LR+ PVA L G WL+T +D+++ + +D R Sbjct 5 SSELPAFPMSKAKGCPLDPPPEYAQLRSDRPVAKARLWDGKEVWLITGYDEIRSIFTDPR 64 Query 61 FSCRAAAHPSSPPF------VPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPV 114 S P P V + +D P+HTA RR+L QG I MR Sbjct 65 ISVDNT-QPGYPWLSEQARTVVLTGGVKPVGRMDPPEHTAMRRMLGQGFLVKKIQNMRGD 123 Query 115 VQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEP--KTVHELAAHVDAAMSV 172 V+ +V+ +DD+ A P D +++P+ + +LGV P K + L + S Sbjct 124 VEALVNELIDDILAGPRPTDLVPSLAMPVPSTALGWVLGVPPADKRLISLVPRLFDEDSG 183 Query 173 CEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTV 232 E E + ++ + + I HR+ +PGDD++S + Q+ ++ V+ +T+ Sbjct 184 LEGAMEARAELFAYIDEL---ITHRE-NQPGDDIISHLV-GYYQKGELSRVSVLTQSVTL 238 Query 233 VIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTE 292 + +DT ++ITNG+ +LL H +Q L+EDP V AVEE++R+ TE RV Sbjct 239 IAAALDTTRSMITNGILALLQHPEQAAALIEDPDLVPAAVEELLRYTVVTEFSSKRVAAA 298 Query 293 DVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYS 352 D+ IAG + AG I++ NRD F DPD DV R+ +H+ FG G H C + Sbjct 299 DIEIAGETIKAGDGIICLISAGNRDEKVFTDPDTLDVRRDAKQHLGFGAGIHTCIGKQLA 358 Query 353 RMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 RM L + +L +R P+L+LA PF+ L R G++ L VTW Sbjct 359 RMELEVVYGTLFRRIPELRLAVPFDQLVFRNT-FDVQGVRALPVTW 403 >gi|45934783|gb|AAS79447.1| P450 [Streptomyces bikiniensis] Length=407 Score = 202 bits (513), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 129/380 (34%), Positives = 189/380 (50%), Gaps = 3/380 (0%) Query 9 FPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAH 68 +PF P P+ S LR PV+ I +P G AWL+TR DV+ VL D RFS A A Sbjct 13 YPFSPPEGIALDPLYSRLREHEPVSRIRMPYGGEAWLLTRHADVRAVLGDPRFSMEAGAG 72 Query 69 PSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAA 128 P + L+S+D P HT RRL + + +RP V + D LD + A Sbjct 73 RDVPRPTEYPLPAGGLISMDPPGHTRLRRLAGKAFTARRVEELRPRVSRFTDELLDGMVA 132 Query 129 A-EPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSAL 187 EP + E +++P+ ++ LLGV H L A+ +G EV R Sbjct 133 RDEPSGEVMEDLALPVSISVICGLLGVSYDDRH-LFRDFSEALVSSSLGPAEVQRATEDF 191 Query 188 CTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNG 247 + D++ + A P DD LST+ QA + +++ +++ M ++I G +T I N Sbjct 192 SAYMADLVADRRARPTDDFLSTMVQARDEGDRLSEAELLMMGSGLLISGYETTATQIGNF 251 Query 248 LASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTALSAGSP 306 + LL R YERLV +P V AVEE++RF P + ++ R+ EDV I GT + AG Sbjct 252 VLLLLDDRRLYERLVTEPDLVPSAVEELLRFTPLSTLDGFARIALEDVEIGGTLIRAGEA 311 Query 307 AFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQR 366 TSI SAN D F D+ R N H+ FG+G H C + +R+ L ++L +R Sbjct 312 VITSIASANLDDTAFPGAASLDLARAQNPHLGFGHGAHYCMGAPLARLELQVVLSTLVER 371 Query 367 FPQLQLARPFEDLERRGKGL 386 P+L+L+ P +L R L Sbjct 372 LPELRLSVPASELRWRAGSL 391 >gi|108863047|gb|ABG22116.1| epothilone b hydroxylase [Amycolatopsis orientalis] Length=404 Score = 201 bits (512), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 130/401 (33%), Positives = 199/401 (50%), Gaps = 16/401 (3%) Query 8 TFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAA 67 T P R P P P LR PV+ + LPSG TAW +TR +D++ +LS FS + Sbjct 10 TLPLARKCPFSPPPEYERLRRESPVSRVGLPSGQTAWALTRLEDIREMLSSPHFSSDRQS 69 Query 68 HPSSPPFV---------PFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQI 118 PS P V PF PSL+++D P+H ARR + + ++P +QQI Sbjct 70 -PSFPLMVARQIRREDKPFR---PSLIAMDPPEHGKARRDVVGEFTVKRMKALQPRIQQI 125 Query 119 VDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDE 178 VD +D L A P D + +S+P+ ++ +LLGV P + HE + M E+ E Sbjct 126 VDEHIDALLAGPKPADLVQALSLPVPSLVICELLGV-PYSDHEFFQSCSSRMLSREVTAE 184 Query 179 EVSRRWSALCTMVIDILHRKLAEPG-DDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGV 237 E + +L + +++ +K A DDLL R+ ++VG+ ++I G Sbjct 185 ERMTAFESLENYLDELVTKKEANATEDDLLGRQILKQRESGEADHGELVGLAFLLLIAGH 244 Query 238 DTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIA 297 +T +I+ G +LL + DQ ++ DPG+ A+EE++R E R T DV I Sbjct 245 ETTANMISLGTVTLLENPDQLAKIKADPGKTLAAIEELLRIFTIAETATSRFATADVEIG 304 Query 298 GTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLT 357 GT + AG + N D D F +PD FD+ER H+AFG+G H C +R+ L Sbjct 305 GTLIRAGEGVVGLSNAGNHDPDGFENPDTFDIERGARHHVAFGFGVHQCLGQNLARLELQ 364 Query 358 TFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 F +L +R P +++A P ++L + G+ L VTW Sbjct 365 IVFDTLFRRVPGIRIAVPVDELPFKHDST-IYGLHALPVTW 404 >gi|14456620|dbj|BAB60855.1| cytochrome P450nor [Trichosporon cutaneum] Length=416 Score = 201 bits (512), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 126/403 (32%), Positives = 203/403 (51%), Gaps = 9/403 (2%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 +++ + P FPF R EP + LR + PV+ ++L G AWLVT+++DV V +D+R Sbjct 18 LSTRAAPKFPFARASGMEPPAEFATLRATNPVSQVQLYDGSLAWLVTKYEDVIKVATDER 77 Query 61 FSCRAAAHPSSPPF----VPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQ 116 S + P P Q P+ + +D P H R L+ P ++ ++P +Q Sbjct 78 LS-KVRTRPGFPELSAGGKAAAQAQPTFVDMDAPDHMKQRGLVEAFFTPEYVEGLKPYIQ 136 Query 117 QIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIG 176 ++D ALD +AA P D ++ + ++ +LGV K + L +A + Sbjct 137 SVIDEALDKMAAKTQPADLVSEFALIVPSYVIYTILGVPLKDLEFLTLQ-NAIRTNGSST 195 Query 177 DEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGG 236 E S + L + ++ ++ EP DDL+ST+ +A + V + +++ G Sbjct 196 AREASAASAGLLEYLGKLVDARMDEPKDDLVSTLCKA-VAAGKLDRTSAVQVAFLLLVAG 254 Query 237 VDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVI 296 T + +I G+A+L + Q E L DP A V+E+ R++ A+ + RV ED+V+ Sbjct 255 NATMVNMIALGVATLAKYPSQLELLKADPSLAANMVQELCRYHTASAMALKRVALEDIVL 314 Query 297 AGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEH-IAFGYGPHACPASAYSRMC 355 G + AG S S NRD+D F DPD FD+ R ++ +AFG+GPH C A +++ Sbjct 315 GGQTIKAGEGIIASNYSGNRDADAFKDPDVFDIRRTFDKDPLAFGWGPHRCIAETLAKVE 374 Query 356 LTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 LT F +L +R P L+ A P ED+ VGI EL VTW Sbjct 375 LTAVFETLYKRLPNLKPAVPLEDIAYSPLD-KDVGIVELPVTW 416 >gi|300782805|ref|YP_003763096.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|299792319|gb|ADJ42694.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|340524180|gb|AEK39385.1| cytochrome P450 [Amycolatopsis mediterranei S699] Length=396 Score = 201 bits (511), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 124/398 (32%), Positives = 198/398 (50%), Gaps = 6/398 (1%) Query 4 TSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSC 63 T++ FP R P P P +E+R PV + LP G AW+V+R +DV+ VL+D+RFS Sbjct 2 TALHEFPMTRTCPFAPPPAYAEIREEDPVTRVGLPDGRKAWVVSRHEDVRTVLNDRRFSA 61 Query 64 RAAAHPSSPPFVPFVQLCP---SLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 HP P VP + +++++D P+H AR+ + + +RP +Q+IVD Sbjct 62 -DRQHPDFPQLVPGFRRPDDERTMITMDAPEHGPARKAVLGEFTVRRMEALRPRIQEIVD 120 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 +D L A P D E +S+P+ ++ ++LGV P H+ + + +E Sbjct 121 ERIDALLAGPKPGDLVEALSLPVPSLVICEMLGV-PYADHDFFQTHTTKLIKRDTPPQER 179 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 A+ + D++ K A P DDLL R++ T + +++ G +T Sbjct 180 RAAVEAVREYMGDLIAGKEANPPDDLLGRQIVKLREEGTYRRAALAATGFLLLVAGHETT 239 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA 300 +I+ G LL + Q + +DPG+ AVEE++R+ + R+ ED + G Sbjct 240 ANMISLGTVGLLENPHQLALIRDDPGKTLDAVEELLRYFTIVDAATARLCVEDAEVGGQL 299 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF 360 + AG +ANRD F +PD+ D+ER H+AFG+GPH C +RM L F Sbjct 300 IRAGEGVLALGYAANRDGTAFENPDDLDIERGARHHVAFGFGPHQCLGQNLARMELQIVF 359 Query 361 TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 +L +R P L+LA P +DL + + G+ L VTW Sbjct 360 DTLFRRIPGLRLAAPVDDLPFKDDA-NIYGLYRLPVTW 396 >gi|271966572|ref|YP_003340768.1| cytochrome P450, nitric oxide reductase [Streptosporangium roseum DSM 43021] gi|270509747|gb|ACZ88025.1| CYP55B1; cytochrome P450, nitric oxide reductase [Streptosporangium roseum DSM 43021] Length=398 Score = 201 bits (510), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 134/399 (34%), Positives = 199/399 (50%), Gaps = 2/399 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MT+ FPF P P L+ LR PV + LP+G AWLVTR++DVK VL D R Sbjct 1 MTTEDPANFPFTFPPGIAQPPELARLREEAPVTRVTLPTGDRAWLVTRYEDVKQVLGDPR 60 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FS AA P +P LL +DGP+H RR + + +RP + + + Sbjct 61 FSRAAAELPGAPQMGASNPGPDVLLGMDGPEHARLRRTATRHFTARRVEALRPWTRLLAE 120 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 +DDL +A PP D ++P+ +L+ LLGV + L A D A S+ +E+ Sbjct 121 RLMDDLISAGPPADMVSRFALPLPLRLVLALLGVPDEDSARLCALTDTAFSMTRHTPQEI 180 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 L + + +++ + P DDLL + ++ +T++Q++ +V G + Sbjct 181 LDARGRLESYMAEMIGIRRRRPTDDLLGALVAERDKEDRLTEQQLISFAFLLVTAGYLST 240 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVIAGT 299 I +G +LL H DQ +RL DP ++ A EE++R NP A LRV EDV + G Sbjct 241 SNAIASGFLTLLAHPDQLDRLRGDPELISSAAEELLRVNPSAITGALLRVALEDVELGGV 300 Query 300 ALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTF 359 + AG +I SAN D+ F DP+ D+ R H+AFGYG H C + +RM L Sbjct 301 GIRAGEGVLPAIGSANHDALLFPDPERLDIVREDASHLAFGYGVHRCLGAHMARMELQVA 360 Query 360 FTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 L +R P +LA P ++L + + S G+ L VTW Sbjct 361 LAVLLERLPAARLAVPEQELVWKDHPV-SRGLVALPVTW 398 >gi|112419473|dbj|BAF02928.1| cytochrome P450 monooxygenase [Streptomyces halstedii] Length=404 Score = 199 bits (507), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 129/400 (33%), Positives = 200/400 (50%), Gaps = 6/400 (1%) Query 3 STSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFS 62 + + P FPF P E P E R PVA +ELP G AWL+TR +VK L D RFS Sbjct 7 TGTCPHFPFSNGRPVELEPEYIEFRRDRPVARVELPYGGEAWLLTRMAEVKEFLGDTRFS 66 Query 63 CRAAAHPSSPPFVPF-VQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDN 121 R A SP + + L +DG QH RRLL + + + +RP V IV++ Sbjct 67 -RQAMKGFSPRYTEAPIADEGGLPMMDGAQHLRTRRLLNKAFSRRRVETLRPAVTAIVND 125 Query 122 ALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVS 181 +D + A E PVD I ++ LLGV + L VD + I E++ Sbjct 126 LVDAMEAGERPVDLVAEFGNAIPREVNCLLLGVPSEDWSRLGRLVDDVIHQGVIPQEQLI 185 Query 182 RRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPI 241 W+ L + ++ + P +DL+S + QA + DE+V+ + V + G +T Sbjct 186 ASWTELTGYFMTMIKDRRTTPTEDLISEMIQARNGEDVFADEEVMMNAVVVFVAGYETTA 245 Query 242 AVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHL-RVVTEDVVIAGTA 300 I N + +LL DQ + L E+ + +AVEE++R+ P T + + ED I G Sbjct 246 CQIVNMICALLRDPDQMKWLGENLDALPQAVEELLRYVPLTAAGVMPSIAAEDAEIGGVP 305 Query 301 LSAGSPAFTSITSANRDSDQFLDPDEFDVERNP--NEHIAFGYGPHACPASAYSRMCLTT 358 +SAG +T + SANRD + F +P++ ++ R N+H+AFG GPH C ++ +R+ L Sbjct 306 ISAGEAVYTCVVSANRDEEVFTEPEKLNLRRGDEVNQHVAFGAGPHYCLGASLARVELQV 365 Query 359 FFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 ++ +R P ++LA P +L + GL G ++ V W Sbjct 366 ALEAVLRRMPGIRLAIPEAELPLK-DGLVLRGFEQFPVVW 404 >gi|300787317|ref|YP_003767608.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|299796831|gb|ADJ47206.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|340528824|gb|AEK44029.1| cytochrome P450 [Amycolatopsis mediterranei S699] Length=403 Score = 199 bits (507), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 119/380 (32%), Positives = 195/380 (52%), Gaps = 4/380 (1%) Query 4 TSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSC 63 T++P FPF P E ++LR V + LP GH WLV R +V+ VL+D RFS Sbjct 6 TALPAFPFRVRTPGEALDEYAKLRAEAAVTRVRLPGGHEGWLVLRHAEVRTVLTDLRFSK 65 Query 64 RAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNAL 123 A P +P +P + SL+++D P HT R+L ++ + +RP +++I + Sbjct 66 EAMTRPDAPRLIPVHRGSRSLVNLDPPDHTRLRKLASREFTQRRVDTLRPRIEEITAGLV 125 Query 124 DDL-AAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVC--EIGDEEV 180 D + +A+ D +++P+ ++ +LLGVEP + D ++V + Sbjct 126 DAMTGSAQTTADAVTALALPLPITVICELLGVEPAEQAQFRQWGDKVLTVGGPGADADAA 185 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 AL + +L RK A PG+DLL+ + QA ++ D ++ + +T++I G T Sbjct 186 REAAGALMGYLTGLLERKRARPGEDLLTRLLQAQEDGDSLDDGELRTLAMTILIAGYHTT 245 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVIAGT 299 ++ +++ L LL +Y+ +V+DPG + AVEE +R++ A +R+ EDV + G Sbjct 246 VSAVSHLLVHLLEDPARYQSIVDDPGLIGTAVEEALRYSQVAGGFGSMRIALEDVELGGV 305 Query 300 ALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTF 359 + AG P I SANRD F DE ++R N H+AFG G H C +A +R+ L Sbjct 306 TIRAGEPVIPLINSANRDESAFAAADELRLDRTDNPHLAFGAGIHFCLGAALARLELRVL 365 Query 360 FTSLTQRFPQLQLARPFEDL 379 +L R L L P ++L Sbjct 366 LETLVARRIPLALGVPVDEL 385 >gi|302541571|ref|ZP_07293913.1| cytochrome P450 107B1 (P450CVIIB1) [Streptomyces hygroscopicus ATCC 53653] gi|302459189|gb|EFL22282.1| cytochrome P450 107B1 (P450CVIIB1) [Streptomyces himastatinicus ATCC 53653] Length=399 Score = 199 bits (506), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 123/399 (31%), Positives = 203/399 (51%), Gaps = 3/399 (0%) Query 1 MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR 60 MTS T+PF + +P+ ++LR+ P+A ++LP G WL TR++D + VL D R Sbjct 1 MTSAQPLTYPF-QAEKLNLAPLYAQLRHEEPLAWVQLPYGEPGWLATRYEDARLVLGDPR 59 Query 61 FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD 120 FS A+ SP P+ ++ + D P+H+ RRL+ + I R+RP VQQ+ D Sbjct 60 FSRAASVGRDSPRVRPYAPGPGTISTFDPPEHSRLRRLVTKAFTVRQIDRLRPRVQQLSD 119 Query 121 NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV 180 + +D + A D E ++P+ ++ +LLGV + + +A +S + EE+ Sbjct 120 DLVDAIRAEGASADLVEDFALPLPITVICELLGVPFEDRADFRLWSEAFLSTTKYTLEEI 179 Query 181 SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP 240 + L + + ++ P DDLLS++ A +++++++ + ++I G +T Sbjct 180 KGYRALLRDYMAGLAEQRRTAPQDDLLSSLVAARENDDRLSEDELLSLSEAILIAGHETT 239 Query 241 IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP-ATEIEHLRVVTEDVVIAGT 299 + N LL D L D V +AVEE++RF P + R ED+ + G Sbjct 240 ATQLGNFFYVLLTQPDHLAALRADLSLVPQAVEELLRFTPLGSGSMQPRYALEDIELGGV 299 Query 300 ALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTF 359 + AG P +I SANRD F D D D+ R H+ FG+GPH C + +RM L Sbjct 300 TVRAGEPVVVAINSANRDEGVFTDSDHLDLRRREATHLGFGHGPHHCLGAPLARMELQIA 359 Query 360 FTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTW 398 +L +R P L+LA D+E + G+ + G++ L VTW Sbjct 360 LRTLLERLPGLRLADAERDVEWK-VGVSTRGVRRLPVTW 397 Lambda K H 0.320 0.135 0.402 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 788774687856 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40