BLASTP 2.2.25+


Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.



Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.



Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
           15,229,318 sequences; 5,219,829,388 total letters



Query= Rv3357

Length=91
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

gi|326327906|pdb|3OEI|A  Chain A, Crystal Structure Of Mycobacter...   187    4e-46
gi|15610493|ref|NP_217874.1|  hypothetical protein Rv3357 [Mycoba...   187    5e-46
gi|289571594|ref|ZP_06451821.1|  conserved hypothetical protein [...   186    1e-45
gi|326327910|pdb|3OEI|E  Chain E, Crystal Structure Of Mycobacter...   185    2e-45
gi|289752066|ref|ZP_06511444.1|  conserved hypothetical protein [...   178    2e-43
gi|240171145|ref|ZP_04749804.1|  prevent-host-death family protei...   156    8e-37
gi|254386626|ref|ZP_05001923.1|  conserved hypothetical protein [...   150    4e-35
gi|108802445|ref|YP_642641.1|  prevent-host-death protein [Mycoba...   149    1e-34
gi|302534753|ref|ZP_07287095.1|  prevent-host-death protein [Stre...   137    4e-31
gi|294629730|ref|ZP_06708290.1|  PHD family toxin-antitoxin syste...   134    6e-30
gi|21220706|ref|NP_626485.1|  hypothetical protein SCO2235 [Strep...   110    1e-22
gi|302545612|ref|ZP_07297954.1|  PHD family toxin-antitoxin syste...   107    4e-22
gi|302545635|ref|ZP_07297977.1|  PHD family toxin-antitoxin syste...   105    2e-21
gi|256832886|ref|YP_003161613.1|  prevent-host-death family prote...   103    8e-21
gi|289705294|ref|ZP_06501693.1|  toxin-antitoxin system, antitoxi...   100    6e-20
gi|86741247|ref|YP_481647.1|  prevent-host-death protein [Frankia...  94.0    6e-18
gi|302535097|ref|ZP_07287439.1|  prevent-host-death protein [Stre...  90.5    8e-17
gi|336178420|ref|YP_004583795.1|  prevent-host-death family prote...  89.4    2e-16
gi|29829748|ref|NP_824382.1|  hypothetical protein SAV_3206 [Stre...  88.2    4e-16
gi|15077435|gb|AAK83162.1|AF333038_2  AviX2 [Streptomyces viridoc...  79.3    2e-13
gi|343521716|ref|ZP_08758682.1|  prevent-host-death family protei...  74.7    4e-12
gi|253700911|ref|YP_003022100.1|  prevent-host-death family prote...  73.9    7e-12
gi|283852875|ref|ZP_06370136.1|  prevent-host-death family protei...  73.9    8e-12
gi|149377191|ref|ZP_01894939.1|  hypothetical protein MDG893_1602...  73.6    9e-12
gi|197118310|ref|YP_002138737.1|  antitoxin YefM, prevent-host-de...  72.4    2e-11
gi|326773841|ref|ZP_08233123.1|  toxin-antitoxin system, antitoxi...  71.2    5e-11
gi|300115367|ref|YP_003761942.1|  prevent-host-death family prote...  71.2    5e-11
gi|324016968|gb|EGB86187.1|  toxin-antitoxin system, antitoxin co...  70.9    6e-11
gi|227887067|ref|ZP_04004872.1|  prevent-host-death family protei...  70.9    6e-11
gi|117624221|ref|YP_853134.1|  antitoxin YefM [Escherichia coli A...  70.9    6e-11
gi|308271728|emb|CBX28336.1|  Antitoxin yefM [uncultured Desulfob...  70.5    7e-11
gi|126659704|ref|ZP_01730833.1|  Antitoxin of toxin-antitoxin sys...  70.5    8e-11
gi|74312560|ref|YP_310979.1|  antitoxin YefM [Shigella sonnei Ss0...  70.5    8e-11
gi|345388433|gb|EGX18244.1|  prevent-host-death family protein [E...  70.5    9e-11
gi|75766064|pdb|2A6Q|A  Chain A, Crystal Structure Of Yefm-Yoeb C...  70.1    1e-10
gi|338769917|gb|EGP24689.1|  Antitoxin yefM [Escherichia coli PCN...  70.1    1e-10
gi|304398753|ref|ZP_07380624.1|  prevent-host-death family protei...  70.1    1e-10
gi|332707577|ref|ZP_08427611.1|  PhdYefM prevent-host-death famil...  69.7    1e-10
gi|50119395|ref|YP_048562.1|  antitoxin YefM [Pectobacterium atro...  69.7    1e-10
gi|121997213|ref|YP_001002000.1|  prevent-host-death family prote...  69.7    1e-10
gi|24113402|ref|NP_707912.1|  antitoxin YefM [Shigella flexneri 2...  69.7    2e-10
gi|345432680|dbj|BAK69010.1|  antitoxin of the YoeB-YefM toxin-an...  69.3    2e-10
gi|320193305|gb|EFW67943.1|  prevent-host-death family protein [E...  69.3    2e-10
gi|335419376|ref|ZP_08550429.1|  prevent-host-death family protei...  68.9    2e-10
gi|121997585|ref|YP_001002372.1|  prevent-host-death family prote...  68.6    3e-10
gi|67924642|ref|ZP_00518053.1|  Prevent-host-death protein [Croco...  68.2    3e-10
gi|238898229|ref|YP_002923910.1|  addiction module antitoxin [Can...  68.2    4e-10
gi|222033788|emb|CAP76529.1|  Antitoxin yefM [Escherichia coli LF...  68.2    4e-10
gi|301061182|ref|ZP_07201971.1|  toxin-antitoxin system, antitoxi...  68.2    4e-10
gi|126665068|ref|ZP_01736051.1|  hypothetical protein MELB17_1840...  67.8    5e-10


>gi|326327906|pdb|3OEI|A Chain A, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
 gi|326327907|pdb|3OEI|B Chain B, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
 gi|326327914|pdb|3OEI|I Chain I, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
 gi|326327915|pdb|3OEI|J Chain J, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
 gi|326327918|pdb|3OEI|M Chain M, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
 gi|326327919|pdb|3OEI|N Chain N, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
Length=98

 Score =  187 bits (475),  Expect = 4e-46, Method: Compositional matrix adjust.
 Identities = 91/91 (100%), Positives = 91/91 (100%), Gaps = 0/91 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR
Sbjct  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91
           RLMEAVARDKAGHSAFTKSVDELREMAGGEE
Sbjct  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91


>gi|15610493|ref|NP_217874.1| hypothetical protein Rv3357 [Mycobacterium tuberculosis H37Rv]
 gi|15842953|ref|NP_337990.1| hypothetical protein MT3465 [Mycobacterium tuberculosis CDC1551]
 gi|31794540|ref|NP_857033.1| hypothetical protein Mb3392 [Mycobacterium bovis AF2122/97]
 85 more sequence titles
 Length=91

 Score =  187 bits (475),  Expect = 5e-46, Method: Compositional matrix adjust.
 Identities = 91/91 (100%), Positives = 91/91 (100%), Gaps = 0/91 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR
Sbjct  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91
           RLMEAVARDKAGHSAFTKSVDELREMAGGEE
Sbjct  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91


>gi|289571594|ref|ZP_06451821.1| conserved hypothetical protein [Mycobacterium tuberculosis T17]
 gi|289545348|gb|EFD48996.1| conserved hypothetical protein [Mycobacterium tuberculosis T17]
Length=91

 Score =  186 bits (472),  Expect = 1e-45, Method: Compositional matrix adjust.
 Identities = 90/91 (99%), Positives = 91/91 (100%), Gaps = 0/91 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           M+ISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR
Sbjct  1   MNISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91
           RLMEAVARDKAGHSAFTKSVDELREMAGGEE
Sbjct  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91


>gi|326327910|pdb|3OEI|E Chain E, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
 gi|326327911|pdb|3OEI|F Chain F, Crystal Structure Of Mycobacterium Tuberculosis Reljk 
(Rv3357-Rv3358- Relbe3)
Length=98

 Score =  185 bits (469),  Expect = 2e-45, Method: Compositional matrix adjust.
 Identities = 90/91 (99%), Positives = 90/91 (99%), Gaps = 0/91 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR
Sbjct  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91
           RLMEAVARD AGHSAFTKSVDELREMAGGEE
Sbjct  61  RLMEAVARDXAGHSAFTKSVDELREMAGGEE  91


>gi|289752066|ref|ZP_06511444.1| conserved hypothetical protein [Mycobacterium tuberculosis T92]
 gi|289692653|gb|EFD60082.1| conserved hypothetical protein [Mycobacterium tuberculosis T92]
Length=91

 Score =  178 bits (452),  Expect = 2e-43, Method: Compositional matrix adjust.
 Identities = 88/91 (97%), Positives = 88/91 (97%), Gaps = 0/91 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEARQRL  LIEQVNTDHQ VRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR
Sbjct  1   MSISASEARQRLVSLIEQVNTDHQLVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91
           RLMEAVARDKAGHSAFTKSVDELREMAGGEE
Sbjct  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91


>gi|240171145|ref|ZP_04749804.1| prevent-host-death family protein [Mycobacterium kansasii ATCC 
12478]
 gi|296165398|ref|ZP_06847939.1| prevent-host-death family antitoxin [Mycobacterium parascrofulaceum 
ATCC BAA-614]
 gi|295899289|gb|EFG78754.1| prevent-host-death family antitoxin [Mycobacterium parascrofulaceum 
ATCC BAA-614]
Length=94

 Score =  156 bits (395),  Expect = 8e-37, Method: Compositional matrix adjust.
 Identities = 76/94 (81%), Positives = 85/94 (91%), Gaps = 3/94 (3%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           M+ISASEARQRLFPL+EQVNTDH+PVRITS+AGDAVLMSA DYD+WQETVYLLRSPENAR
Sbjct  1   MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENAR  60

Query  61  RLMEAVARDKAGH---SAFTKSVDELREMAGGEE  91
           RLMEAVARD A      ++TKS+DEL EMAGG+E
Sbjct  61  RLMEAVARDNATRPTPGSYTKSIDELEEMAGGQE  94


>gi|254386626|ref|ZP_05001923.1| conserved hypothetical protein [Streptomyces sp. Mg1]
 gi|194345468|gb|EDX26434.1| conserved hypothetical protein [Streptomyces sp. Mg1]
Length=91

 Score =  150 bits (380),  Expect = 4e-35, Method: Compositional matrix adjust.
 Identities = 73/91 (81%), Positives = 81/91 (90%), Gaps = 0/91 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEAR  LFPLIE+VNTDH PVRITS+ GDAVLMSADDYD+WQETVYLLRSP NA+
Sbjct  1   MSISASEARATLFPLIERVNTDHDPVRITSKNGDAVLMSADDYDSWQETVYLLRSPANAQ  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGEE  91
           RLMEAVARD+ G  A TKS++ELR +AGGEE
Sbjct  61  RLMEAVARDREGAPAVTKSMEELRRLAGGEE  91


>gi|108802445|ref|YP_642641.1| prevent-host-death protein [Mycobacterium sp. MCS]
 gi|119855271|ref|YP_935874.1| prevent-host-death family protein [Mycobacterium sp. KMS]
 gi|108772864|gb|ABG11585.1| Prevent-host-death protein [Mycobacterium sp. MCS]
 gi|119697988|gb|ABL95059.1| prevent-host-death family protein [Mycobacterium sp. KMS]
Length=94

 Score =  149 bits (377),  Expect = 1e-34, Method: Compositional matrix adjust.
 Identities = 73/94 (78%), Positives = 82/94 (88%), Gaps = 3/94 (3%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEARQRLFPL+EQVN+DH+PVRITS+AGDAVLMSA DYD+WQETVYLLRSPENAR
Sbjct  1   MSISASEARQRLFPLLEQVNSDHEPVRITSKAGDAVLMSAQDYDSWQETVYLLRSPENAR  60

Query  61  RLMEAVARDKAGHS---AFTKSVDELREMAGGEE  91
           RLMEAVARD+AG         +V EL E+AGG+E
Sbjct  61  RLMEAVARDRAGRPESVGHATTVGELEELAGGQE  94


>gi|302534753|ref|ZP_07287095.1| prevent-host-death protein [Streptomyces sp. C]
 gi|302443648|gb|EFL15464.1| prevent-host-death protein [Streptomyces sp. C]
Length=90

 Score =  137 bits (346),  Expect = 4e-31, Method: Compositional matrix adjust.
 Identities = 65/90 (73%), Positives = 76/90 (85%), Gaps = 0/90 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           M ISASEAR+ LFPLIE+VN DH PVRI+S+ GDAVLMSA+DYD+WQETVYLLRSP NAR
Sbjct  1   MPISASEARKTLFPLIERVNNDHTPVRISSKNGDAVLMSAEDYDSWQETVYLLRSPANAR  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGE  90
           RLMEAVARD+ G +   KS++EL  +AG E
Sbjct  61  RLMEAVARDREGTTGIAKSMEELNALAGEE  90


>gi|294629730|ref|ZP_06708290.1| PHD family toxin-antitoxin system, antitoxin component [Streptomyces 
sp. e14]
 gi|292833063|gb|EFF91412.1| PHD family toxin-antitoxin system, antitoxin component [Streptomyces 
sp. e14]
Length=90

 Score =  134 bits (336),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 64/90 (72%), Positives = 77/90 (86%), Gaps = 0/90 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           M+ISASEAR+ LFPLI++VN DH PV I+SR GDAVLMSA DYD+WQETVYLLRSP NAR
Sbjct  1   MTISASEARRDLFPLIKRVNDDHTPVHISSRGGDAVLMSAADYDSWQETVYLLRSPANAR  60

Query  61  RLMEAVARDKAGHSAFTKSVDELREMAGGE  90
           RLMEAVARD+AG +  ++S+ EL+ +AG E
Sbjct  61  RLMEAVARDRAGTAGLSRSMAELQALAGEE  90


>gi|21220706|ref|NP_626485.1| hypothetical protein SCO2235 [Streptomyces coelicolor A3(2)]
 gi|289772038|ref|ZP_06531416.1| conserved hypothetical protein [Streptomyces lividans TK24]
 gi|6226501|sp|Q9Z4V7.1|YEFM_STRCO RecName: Full=Antitoxin YefM; AltName: Full=ORFU1E
 gi|4469319|emb|CAB38327.1| hypothetical protein [Streptomyces coelicolor A3(2)]
 gi|13751880|emb|CAC37261.1| conserved hypothetical protein [Streptomyces coelicolor A3(2)]
 gi|289702237|gb|EFD69666.1| conserved hypothetical protein [Streptomyces lividans TK24]
Length=87

 Score =  110 bits (274),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 51/72 (71%), Positives = 61/72 (85%), Gaps = 0/72 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSI+ASEARQ LFPLIEQVN DH PV ITSR G+AVLMS +D+ AW ETV+LLRSP NAR
Sbjct  1   MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNAR  60

Query  61  RLMEAVARDKAG  72
           RL++++A  +AG
Sbjct  61  RLLDSIAEAEAG  72


>gi|302545612|ref|ZP_07297954.1| PHD family toxin-antitoxin system, antitoxin component [Streptomyces 
hygroscopicus ATCC 53653]
 gi|302463230|gb|EFL26323.1| PHD family toxin-antitoxin system, antitoxin component [Streptomyces 
himastatinicus ATCC 53653]
Length=87

 Score =  107 bits (268),  Expect = 4e-22, Method: Compositional matrix adjust.
 Identities = 49/81 (61%), Positives = 64/81 (80%), Gaps = 0/81 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSI+ASEARQ LFPLIEQVN DH PV ITSR G+AVLMS +D+ +W ETV+LLRSP+NAR
Sbjct  1   MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTSWTETVHLLRSPKNAR  60

Query  61  RLMEAVARDKAGHSAFTKSVD  81
           RL++++   + G +   + +D
Sbjct  61  RLLDSITEAEGGQTQQRELID  81


>gi|302545635|ref|ZP_07297977.1| PHD family toxin-antitoxin system, antitoxin component [Streptomyces 
hygroscopicus ATCC 53653]
 gi|302463253|gb|EFL26346.1| PHD family toxin-antitoxin system, antitoxin component [Streptomyces 
himastatinicus ATCC 53653]
Length=87

 Score =  105 bits (262),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 49/81 (61%), Positives = 64/81 (80%), Gaps = 0/81 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           M I+ASEARQ LFPLIEQVN DH PV ITSR G+AVLMS +D+ +W ETV+LLRSP+NAR
Sbjct  1   MPITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTSWTETVHLLRSPKNAR  60

Query  61  RLMEAVARDKAGHSAFTKSVD  81
           RL++++A  + G +   + +D
Sbjct  61  RLLDSIAEAEDGKAQQRELID  81


>gi|256832886|ref|YP_003161613.1| prevent-host-death family protein [Jonesia denitrificans DSM 
20603]
 gi|256686417|gb|ACV09310.1| prevent-host-death family protein [Jonesia denitrificans DSM 
20603]
Length=92

 Score =  103 bits (257),  Expect = 8e-21, Method: Compositional matrix adjust.
 Identities = 49/72 (69%), Positives = 58/72 (81%), Gaps = 0/72 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEAR+ LFPLIE+VN DH+ + I SR G+AVLM AD+Y AWQET YL RSP NAR
Sbjct  1   MSISASEARKTLFPLIERVNQDHEAIEIVSRKGNAVLMPADEYAAWQETAYLFRSPANAR  60

Query  61  RLMEAVARDKAG  72
           RL++A  R +AG
Sbjct  61  RLLDAYDRARAG  72


>gi|289705294|ref|ZP_06501693.1| toxin-antitoxin system, antitoxin component, PHD family [Micrococcus 
luteus SK58]
 gi|289558044|gb|EFD51336.1| toxin-antitoxin system, antitoxin component, PHD family [Micrococcus 
luteus SK58]
Length=86

 Score =  100 bits (250),  Expect = 6e-20, Method: Compositional matrix adjust.
 Identities = 49/72 (69%), Positives = 56/72 (78%), Gaps = 0/72 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSISASEAR+ LFPLIE+VN D   V I SR G+AVLM AD+Y AWQET YL RSP NAR
Sbjct  1   MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANAR  60

Query  61  RLMEAVARDKAG  72
           RL++A  R +AG
Sbjct  61  RLLDAYERARAG  72


>gi|86741247|ref|YP_481647.1| prevent-host-death protein [Frankia sp. CcI3]
 gi|86568109|gb|ABD11918.1| Prevent-host-death protein [Frankia sp. CcI3]
Length=85

 Score = 94.0 bits (232),  Expect = 6e-18, Method: Compositional matrix adjust.
 Identities = 45/71 (64%), Positives = 58/71 (82%), Gaps = 0/71 (0%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARR  61
           +ISASEAR+ LFPL+EQVN DH PV I S+ G+AVL+S +D+DA  ET YLLR+P NARR
Sbjct  4   AISASEARKTLFPLLEQVNADHTPVEIVSKRGNAVLVSKEDWDAIVETNYLLRTPANARR  63

Query  62  LMEAVARDKAG  72
           LME+V + ++G
Sbjct  64  LMESVEQWRSG  74


>gi|302535097|ref|ZP_07287439.1| prevent-host-death protein [Streptomyces sp. C]
 gi|302443992|gb|EFL15808.1| prevent-host-death protein [Streptomyces sp. C]
Length=79

 Score = 90.5 bits (223),  Expect = 8e-17, Method: Compositional matrix adjust.
 Identities = 42/68 (62%), Positives = 54/68 (80%), Gaps = 1/68 (1%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSR-AGDAVLMSADDYDAWQETVYLLRSPENA  59
           M ISA  AR+R +PLI QVN DH P+ +TSR  GD V+MSA+D+ +WQETV+LLRSP NA
Sbjct  1   MPISAKHARRRFYPLIRQVNEDHVPLEVTSREHGDVVIMSAEDFRSWQETVHLLRSPRNA  60

Query  60  RRLMEAVA  67
           + LME++A
Sbjct  61  QALMESIA  68


>gi|336178420|ref|YP_004583795.1| prevent-host-death family protein [Frankia symbiont of Datisca 
glomerata]
 gi|334859400|gb|AEH09874.1| prevent-host-death family protein [Frankia symbiont of Datisca 
glomerata]
Length=85

 Score = 89.4 bits (220),  Expect = 2e-16, Method: Compositional matrix adjust.
 Identities = 42/73 (58%), Positives = 58/73 (80%), Gaps = 0/73 (0%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARR  61
           +ISASEAR+ LFPLIE+VN DH PV I S+ G+AVL+S +D+D+  ET YLLRSP NA+R
Sbjct  4   AISASEARKTLFPLIERVNADHAPVEIVSKHGNAVLVSKEDWDSIMETNYLLRSPANAKR  63

Query  62  LMEAVARDKAGHS  74
           L E++ + + G++
Sbjct  64  LTESIDQWRTGNA  76


>gi|29829748|ref|NP_824382.1| hypothetical protein SAV_3206 [Streptomyces avermitilis MA-4680]
 gi|29606857|dbj|BAC70917.1| hypothetical protein [Streptomyces avermitilis MA-4680]
Length=93

 Score = 88.2 bits (217),  Expect = 4e-16, Method: Compositional matrix adjust.
 Identities = 41/65 (64%), Positives = 54/65 (84%), Gaps = 0/65 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSI+ASEAR+ LFPLI++VN DH+ + I S+ G+AVL+SA+DY A +E  YLLRSP NAR
Sbjct  1   MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPVNAR  60

Query  61  RLMEA  65
           RL++A
Sbjct  61  RLLKA  65


>gi|15077435|gb|AAK83162.1|AF333038_2 AviX2 [Streptomyces viridochromogenes]
Length=93

 Score = 79.3 bits (194),  Expect = 2e-13, Method: Compositional matrix adjust.
 Identities = 36/65 (56%), Positives = 51/65 (79%), Gaps = 0/65 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MSI+   +R+ LFPLI++VN +H+ + I S+ G+AVL+SA+DY A +E  YLLRSP NAR
Sbjct  1   MSINRERSRKALFPLIKKVNDNHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANAR  60

Query  61  RLMEA  65
           RL++A
Sbjct  61  RLLKA  65


>gi|343521716|ref|ZP_08758682.1| prevent-host-death family protein [Actinomyces sp. oral taxon 
175 str. F0384]
 gi|343401125|gb|EGV13631.1| prevent-host-death family protein [Actinomyces sp. oral taxon 
175 str. F0384]
Length=77

 Score = 74.7 bits (182),  Expect = 4e-12, Method: Compositional matrix adjust.
 Identities = 40/77 (52%), Positives = 49/77 (64%), Gaps = 0/77 (0%)

Query  1   MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           MS+SA EA + L  LI+++ T H  V I S  G AVLM AD+Y +WQET YL RS +NAR
Sbjct  1   MSVSADEASRMLPALIDRIATSHHAVEIVSSNGRAVLMPADEYASWQETAYLFRSTKNAR  60

Query  61  RLMEAVARDKAGHSAFT  77
           RL+ A  R   G  A T
Sbjct  61  RLLYAYERALTGSRART  77


>gi|253700911|ref|YP_003022100.1| prevent-host-death family protein [Geobacter sp. M21]
 gi|251775761|gb|ACT18342.1| prevent-host-death family protein [Geobacter sp. M21]
Length=83

 Score = 73.9 bits (180),  Expect = 7e-12, Method: Compositional matrix adjust.
 Identities = 38/81 (47%), Positives = 54/81 (67%), Gaps = 1/81 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGD-AVLMSADDYDAWQETVYLLRSPENAR  60
           SI+ S  R +L   +E+V  DH PV IT +A    V+MS DDY+A +ET YLLRSP+N R
Sbjct  3   SITYSSVRSKLAETMEKVCDDHAPVIITRKAAKPVVMMSLDDYEALEETAYLLRSPKNVR  62

Query  61  RLMEAVARDKAGHSAFTKSVD  81
           RL+E++A  + G +A  + +D
Sbjct  63  RLVESIAELETGKAAERELID  83


>gi|283852875|ref|ZP_06370136.1| prevent-host-death family protein [Desulfovibrio sp. FW1012B]
 gi|283571704|gb|EFC19703.1| prevent-host-death family protein [Desulfovibrio sp. FW1012B]
Length=85

 Score = 73.9 bits (180),  Expect = 8e-12, Method: Compositional matrix adjust.
 Identities = 40/82 (49%), Positives = 54/82 (66%), Gaps = 1/82 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDAV-LMSADDYDAWQETVYLLRSPENAR  60
           +IS + AR+ L   +EQV  DH PV IT + G AV +MS +DY+A +ET YLLRSP NA 
Sbjct  3   AISYTHAREHLASTMEQVCNDHAPVVITRQKGRAVVMMSLEDYNAIEETAYLLRSPANAA  62

Query  61  RLMEAVARDKAGHSAFTKSVDE  82
           RL  ++AR KAG +     ++E
Sbjct  63  RLRASLARAKAGEAEVHGLIEE  84


>gi|149377191|ref|ZP_01894939.1| hypothetical protein MDG893_16022 [Marinobacter algicola DG893]
 gi|149358490|gb|EDM46964.1| hypothetical protein MDG893_16022 [Marinobacter algicola DG893]
Length=83

 Score = 73.6 bits (179),  Expect = 9e-12, Method: Compositional matrix adjust.
 Identities = 38/72 (53%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRIT-SRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           +IS + AR  L   +EQV  DH PV IT S+A   V++S +DY+A QET YLLR+P+NAR
Sbjct  3   AISYTAARTNLAKTMEQVCEDHSPVIITRSKAQSVVMISLEDYEALQETAYLLRAPKNAR  62

Query  61  RLMEAVARDKAG  72
           RL+E+VA  + G
Sbjct  63  RLLESVAELEQG  74


>gi|197118310|ref|YP_002138737.1| antitoxin YefM, prevent-host-death family [Geobacter bemidjiensis 
Bem]
 gi|197087670|gb|ACH38941.1| antitoxin YefM, prevent-host-death family [Geobacter bemidjiensis 
Bem]
Length=83

 Score = 72.4 bits (176),  Expect = 2e-11, Method: Compositional matrix adjust.
 Identities = 37/81 (46%), Positives = 53/81 (66%), Gaps = 1/81 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGD-AVLMSADDYDAWQETVYLLRSPENAR  60
           SI+ S  R +L   +E+V  DH PV IT +A    V+MS DDY+A +ET YLLRSP+N R
Sbjct  3   SITYSSVRSKLAETMEKVCDDHAPVIITRKAAKPVVMMSLDDYEALEETAYLLRSPKNVR  62

Query  61  RLMEAVARDKAGHSAFTKSVD  81
           RL+E++A  + G +   + +D
Sbjct  63  RLVESIAELETGKATERELID  83


>gi|326773841|ref|ZP_08233123.1| toxin-antitoxin system, antitoxin component, PHD family [Actinomyces 
viscosus C505]
 gi|326635980|gb|EGE36884.1| toxin-antitoxin system, antitoxin component, PHD family [Actinomyces 
viscosus C505]
Length=86

 Score = 71.2 bits (173),  Expect = 5e-11, Method: Compositional matrix adjust.
 Identities = 34/64 (54%), Positives = 46/64 (72%), Gaps = 0/64 (0%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARR  61
           ++SA EA + L  LI+++ T H  V I S  G AVLM AD+Y +WQET +L RSP+NARR
Sbjct  11  TVSADEASRTLPALIDRIATSHHAVEIVSSNGRAVLMPADEYASWQETAHLFRSPKNARR  70

Query  62  LMEA  65
           L++A
Sbjct  71  LLDA  74


>gi|300115367|ref|YP_003761942.1| prevent-host-death family protein [Nitrosococcus watsonii C-113]
 gi|299541304|gb|ADJ29621.1| prevent-host-death family protein [Nitrosococcus watsonii C-113]
Length=83

 Score = 71.2 bits (173),  Expect = 5e-11, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 48/72 (67%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLM-SADDYDAWQETVYLLRSPENAR  60
           SIS + AR  L   +EQV  DH P+ IT +   AV+M S +DY A +ET YLLRSP+N R
Sbjct  3   SISYTAARSNLAKTMEQVCNDHAPIAITRKGESAVVMISMEDYQALEETAYLLRSPKNTR  62

Query  61  RLMEAVARDKAG  72
           RL+E++A  + G
Sbjct  63  RLIESIAELEMG  74


>gi|324016968|gb|EGB86187.1| toxin-antitoxin system, antitoxin component, PHD family [Escherichia 
coli MS 117-3]
Length=92

 Score = 70.9 bits (172),  Expect = 6e-11, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  12  TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  71

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  72  RLMDSIDSLKSG  83


>gi|227887067|ref|ZP_04004872.1| prevent-host-death family protein [Escherichia coli 83972]
 gi|300974055|ref|ZP_07172429.1| toxin-antitoxin system, antitoxin component, PHD family [Escherichia 
coli MS 200-1]
 gi|300986930|ref|ZP_07177906.1| toxin-antitoxin system, antitoxin component, PHD family [Escherichia 
coli MS 45-1]
 13 more sequence titles
 Length=92

 Score = 70.9 bits (172),  Expect = 6e-11, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  12  TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  71

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  72  RLMDSIDSLKSG  83


>gi|117624221|ref|YP_853134.1| antitoxin YefM [Escherichia coli APEC O1]
 gi|237704475|ref|ZP_04534956.1| antitoxin YefM [Escherichia sp. 3_2_53FAA]
 gi|300816647|ref|ZP_07096868.1| toxin-antitoxin system, antitoxin component, PHD family [Escherichia 
coli MS 107-1]
 25 more sequence titles
 Length=92

 Score = 70.9 bits (172),  Expect = 6e-11, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  12  TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  71

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  72  RLMDSIDSLKSG  83


>gi|308271728|emb|CBX28336.1| Antitoxin yefM [uncultured Desulfobacterium sp.]
Length=83

 Score = 70.5 bits (171),  Expect = 7e-11, Method: Compositional matrix adjust.
 Identities = 34/72 (48%), Positives = 52/72 (73%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDAV-LMSADDYDAWQETVYLLRSPENAR  60
           +IS + ARQ L   + +V  +H PV +T + GD+V +MS +DY+A +ET YLLRSP+N R
Sbjct  3   AISYTAARQNLAKTMGKVCREHAPVIVTRKTGDSVVIMSLEDYEALEETAYLLRSPKNTR  62

Query  61  RLMEAVARDKAG  72
           RL+E++A+ + G
Sbjct  63  RLIESIAQLENG  74


>gi|126659704|ref|ZP_01730833.1| Antitoxin of toxin-antitoxin system StbD [Cyanothece sp. CCY0110]
 gi|126619049|gb|EAZ89789.1| Antitoxin of toxin-antitoxin system StbD [Cyanothece sp. CCY0110]
Length=87

 Score = 70.5 bits (171),  Expect = 8e-11, Method: Compositional matrix adjust.
 Identities = 35/70 (50%), Positives = 46/70 (66%), Gaps = 0/70 (0%)

Query  3   ISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRL  62
           +SAS+AR  LF L+E+VN DH P  ITS+ GDAVL+S DD+++ QET+YL   P     +
Sbjct  4   VSASKARANLFSLVEEVNKDHLPRMITSKKGDAVLLSKDDWESLQETLYLQSIPGLVESI  63

Query  63  MEAVARDKAG  72
            EA   D  G
Sbjct  64  KEAEKADDWG  73


>gi|74312560|ref|YP_310979.1| antitoxin YefM [Shigella sonnei Ss046]
 gi|90111372|ref|NP_416521.2| antitoxin of the YoeB-YefM toxin-antitoxin system [Escherichia 
coli str. K-12 substr. MG1655]
 gi|110642231|ref|YP_669961.1| antitoxin YefM [Escherichia coli 536]
 127 more sequence titles
 Length=83

 Score = 70.5 bits (171),  Expect = 8e-11, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  3   TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  62

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  63  RLMDSIDSLKSG  74


>gi|345388433|gb|EGX18244.1| prevent-host-death family protein [Escherichia coli STEC_S1191]
Length=83

 Score = 70.5 bits (171),  Expect = 9e-11, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  3   TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  62

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  63  RLMDSIDSLKSG  74


>gi|75766064|pdb|2A6Q|A Chain A, Crystal Structure Of Yefm-Yoeb Complex
 gi|75766065|pdb|2A6Q|B Chain B, Crystal Structure Of Yefm-Yoeb Complex
 gi|75766066|pdb|2A6Q|C Chain C, Crystal Structure Of Yefm-Yoeb Complex
 gi|75766067|pdb|2A6Q|D Chain D, Crystal Structure Of Yefm-Yoeb Complex
Length=86

 Score = 70.1 bits (170),  Expect = 1e-10, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  6   TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  65

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  66  RLMDSIDSLKSG  77


>gi|338769917|gb|EGP24689.1| Antitoxin yefM [Escherichia coli PCN033]
Length=83

 Score = 70.1 bits (170),  Expect = 1e-10, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  3   TISYSEARQNLSATMMKAVDDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  62

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  63  RLMDSIDSLKSG  74


>gi|304398753|ref|ZP_07380624.1| prevent-host-death family protein [Pantoea sp. aB]
 gi|304353700|gb|EFM18076.1| prevent-host-death family protein [Pantoea sp. aB]
Length=83

 Score = 70.1 bits (170),  Expect = 1e-10, Method: Compositional matrix adjust.
 Identities = 37/73 (51%), Positives = 50/73 (69%), Gaps = 1/73 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGD-AVLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + Q   D  PV IT + G+  VLMS D+Y++ +ET YLLRSP+NAR
Sbjct  3   AISYSEARQNLSATMVQTVEDKAPVLITRQNGESCVLMSLDEYNSLEETAYLLRSPKNAR  62

Query  61  RLMEAVARDKAGH  73
           RLM+A+   ++G 
Sbjct  63  RLMDAIESLQSGK  75


>gi|332707577|ref|ZP_08427611.1| PhdYefM prevent-host-death family protein [Lyngbya majuscula 
3L]
 gi|332353650|gb|EGJ33156.1| PhdYefM prevent-host-death family protein [Lyngbya majuscula 
3L]
Length=83

 Score = 69.7 bits (169),  Expect = 1e-10, Method: Compositional matrix adjust.
 Identities = 36/75 (48%), Positives = 50/75 (67%), Gaps = 1/75 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRA-GDAVLMSADDYDAWQETVYLLRSPENAR  60
           SIS + AR  L   +E+V  DH PV IT +  G  V++S +DY + +ET YLLRSP+NA+
Sbjct  3   SISYTSARGNLAKTMEKVCQDHAPVAITRKGEGAVVMISMEDYQSLEETAYLLRSPKNAQ  62

Query  61  RLMEAVARDKAGHSA  75
           RL+ AVA  +AG  +
Sbjct  63  RLISAVAELEAGKGS  77


>gi|50119395|ref|YP_048562.1| antitoxin YefM [Pectobacterium atrosepticum SCRI1043]
 gi|49609921|emb|CAG73359.1| conserved hypothetical protein [Pectobacterium atrosepticum SCRI1043]
Length=83

 Score = 69.7 bits (169),  Expect = 1e-10, Method: Compositional matrix adjust.
 Identities = 36/74 (49%), Positives = 51/74 (69%), Gaps = 1/74 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   D  P+ IT + G+A VLMS ++Y++ +ET YLLRSP NA+
Sbjct  3   TISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAK  62

Query  61  RLMEAVARDKAGHS  74
           RLM ++   KAG+S
Sbjct  63  RLMNSIESLKAGNS  76


>gi|121997213|ref|YP_001002000.1| prevent-host-death family protein [Halorhodospira halophila SL1]
 gi|121588618|gb|ABM61198.1| prevent-host-death family protein [Halorhodospira halophila SL1]
Length=87

 Score = 69.7 bits (169),  Expect = 1e-10, Method: Compositional matrix adjust.
 Identities = 36/68 (53%), Positives = 47/68 (70%), Gaps = 1/68 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGD-AVLMSADDYDAWQETVYLLRSPENAR  60
           +IS ++AR  L  LI++V TDH PVRI  R G  AV+M+ +DY   QET+YLL +P NA 
Sbjct  3   TISYTDARNHLKELIDRVGTDHTPVRIERRGGSAAVIMAEEDYTGLQETLYLLGNPANAE  62

Query  61  RLMEAVAR  68
           RL +A AR
Sbjct  63  RLRQARAR  70


>gi|24113402|ref|NP_707912.1| antitoxin YefM [Shigella flexneri 2a str. 301]
 gi|30063468|ref|NP_837639.1| antitoxin YefM [Shigella flexneri 2a str. 2457T]
 gi|110805991|ref|YP_689511.1| antitoxin YefM [Shigella flexneri 5 str. 8401]
 gi|60390849|sp|Q83KJ8.1|YEFM_SHIFL RecName: Full=Antitoxin YefM
 gi|24052422|gb|AAN43619.1| conserved hypothetical protein [Shigella flexneri 2a str. 301]
 gi|30041721|gb|AAP17448.1| hypothetical protein S2201 [Shigella flexneri 2a str. 2457T]
 gi|110615539|gb|ABF04206.1| conserved hypothetical protein [Shigella flexneri 5 str. 8401]
 gi|281601470|gb|ADA74454.1| Antitoxin yefM [Shigella flexneri 2002017]
Length=90

 Score = 69.7 bits (169),  Expect = 2e-10, Method: Compositional matrix adjust.
 Identities = 36/72 (50%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  3   TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  62

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  63  RLMDSIDSLKSG  74


>gi|345432680|dbj|BAK69010.1| antitoxin of the YoeB-YefM toxin-antitoxin system [Escherichia 
coli O157:HNM]
Length=83

 Score = 69.3 bits (168),  Expect = 2e-10, Method: Compositional matrix adjust.
 Identities = 35/72 (49%), Positives = 51/72 (71%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  3   TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  62

Query  61  RLMEAVARDKAG  72
           +LM+++   K+G
Sbjct  63  KLMDSIDSLKSG  74


>gi|320193305|gb|EFW67943.1| prevent-host-death family protein [Escherichia coli WV_060327]
Length=83

 Score = 69.3 bits (168),  Expect = 2e-10, Method: Compositional matrix adjust.
 Identities = 35/72 (49%), Positives = 50/72 (70%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGD-AVLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+  VLMS ++Y++ +ET YLLRSP NAR
Sbjct  3   TISYSEARQNLSATMMKAVEDHAPILITRQNGESCVLMSLEEYNSLEETAYLLRSPANAR  62

Query  61  RLMEAVARDKAG  72
           RLM+++   K+G
Sbjct  63  RLMDSIDSLKSG  74


>gi|335419376|ref|ZP_08550429.1| prevent-host-death family protein [Salinisphaera shabanensis 
E1L3A]
 gi|334896749|gb|EGM34895.1| prevent-host-death family protein [Salinisphaera shabanensis 
E1L3A]
Length=83

 Score = 68.9 bits (167),  Expect = 2e-10, Method: Compositional matrix adjust.
 Identities = 36/67 (54%), Positives = 48/67 (72%), Gaps = 1/67 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRIT-SRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           +IS + AR  L   +EQV  DH P+ IT ++A   V+MS +DY+A QET YLLR+P NAR
Sbjct  3   AISYTAARTNLARTMEQVCEDHSPMIITRNKARSVVMMSLEDYEALQETAYLLRAPRNAR  62

Query  61  RLMEAVA  67
           RL+E+VA
Sbjct  63  RLLESVA  69


>gi|121997585|ref|YP_001002372.1| prevent-host-death family protein [Halorhodospira halophila SL1]
 gi|121588990|gb|ABM61570.1| prevent-host-death family protein [Halorhodospira halophila SL1]
Length=83

 Score = 68.6 bits (166),  Expect = 3e-10, Method: Compositional matrix adjust.
 Identities = 34/67 (51%), Positives = 51/67 (77%), Gaps = 1/67 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRIT-SRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           +IS + AR++L   +++V  DH P+ IT ++A   V++S +DY+A QET YLLRSP+NAR
Sbjct  3   AISYTAARRQLASTMDKVCEDHAPIIITRNKAQSVVMISLEDYEALQETAYLLRSPKNAR  62

Query  61  RLMEAVA  67
           RL+E+VA
Sbjct  63  RLLESVA  69


>gi|67924642|ref|ZP_00518053.1| Prevent-host-death protein [Crocosphaera watsonii WH 8501]
 gi|67853515|gb|EAM48863.1| Prevent-host-death protein [Crocosphaera watsonii WH 8501]
Length=84

 Score = 68.2 bits (165),  Expect = 3e-10, Method: Compositional matrix adjust.
 Identities = 33/80 (42%), Positives = 54/80 (68%), Gaps = 1/80 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGD-AVLMSADDYDAWQETVYLLRSPENAR  60
           +I++S+A+++L  LIEQV  D +P  + +  G  AVLMS D+++AWQET+YLL +P N  
Sbjct  3   AITSSQAKEQLDELIEQVILDVEPTIVCNAQGKKAVLMSLDEFNAWQETLYLLSNPANPE  62

Query  61  RLMEAVARDKAGHSAFTKSV  80
            L E++ + K+G  +  K +
Sbjct  63  HLRESIKQAKSGQKSVRKLI  82


>gi|238898229|ref|YP_002923910.1| addiction module antitoxin [Candidatus Hamiltonella defensa 5AT 
(Acyrthosiphon pisum)]
 gi|229465988|gb|ACQ67762.1| addiction module antitoxin [Candidatus Hamiltonella defensa 5AT 
(Acyrthosiphon pisum)]
Length=83

 Score = 68.2 bits (165),  Expect = 4e-10, Method: Compositional matrix adjust.
 Identities = 36/73 (50%), Positives = 49/73 (68%), Gaps = 1/73 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGD-AVLMSADDYDAWQETVYLLRSPENAR  60
           ++S SEARQ L   + Q   D  PV IT + G+  VLMS D+Y++ +ET YL+RSP+NAR
Sbjct  3   AVSYSEARQNLSTTMIQTIEDRAPVLITRQNGESCVLMSLDEYNSLEETAYLMRSPKNAR  62

Query  61  RLMEAVARDKAGH  73
           RLM++V   K G 
Sbjct  63  RLMDSVESLKEGF  75


>gi|222033788|emb|CAP76529.1| Antitoxin yefM [Escherichia coli LF82]
 gi|312946646|gb|ADR27473.1| antitoxin YefM [Escherichia coli O83:H1 str. NRG 857C]
 gi|333968906|gb|AEG35711.1| Antitoxin YefM [Escherichia coli NA114]
Length=83

 Score = 68.2 bits (165),  Expect = 4e-10, Method: Compositional matrix adjust.
 Identities = 34/66 (52%), Positives = 48/66 (73%), Gaps = 1/66 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDA-VLMSADDYDAWQETVYLLRSPENAR  60
           +IS SEARQ L   + +   DH P+ IT + G+A VLMS ++Y++ +ET YLLRSP NAR
Sbjct  3   TISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAR  62

Query  61  RLMEAV  66
           RLM+++
Sbjct  63  RLMDSI  68


>gi|301061182|ref|ZP_07201971.1| toxin-antitoxin system, antitoxin component, PHD family [delta 
proteobacterium NaphS2]
 gi|300444724|gb|EFK08700.1| toxin-antitoxin system, antitoxin component, PHD family [delta 
proteobacterium NaphS2]
Length=83

 Score = 68.2 bits (165),  Expect = 4e-10, Method: Compositional matrix adjust.
 Identities = 31/73 (43%), Positives = 53/73 (73%), Gaps = 1/73 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRITSRAGDAV-LMSADDYDAWQETVYLLRSPENAR  60
           +I+ + ARQ L   +E+V  DH P+ +T ++ ++V +MS +D+ A +ET YLLRSP+N R
Sbjct  3   AITYTAARQNLAKTMEKVCNDHAPMIVTRKSSESVVIMSLEDFQALEETAYLLRSPKNTR  62

Query  61  RLMEAVARDKAGH  73
           RL+E++A+ + G+
Sbjct  63  RLIESIAQLENGN  75


>gi|126665068|ref|ZP_01736051.1| hypothetical protein MELB17_18409 [Marinobacter sp. ELB17]
 gi|126630438|gb|EBA01053.1| hypothetical protein MELB17_18409 [Marinobacter sp. ELB17]
Length=83

 Score = 67.8 bits (164),  Expect = 5e-10, Method: Compositional matrix adjust.
 Identities = 35/72 (49%), Positives = 50/72 (70%), Gaps = 1/72 (1%)

Query  2   SISASEARQRLFPLIEQVNTDHQPVRIT-SRAGDAVLMSADDYDAWQETVYLLRSPENAR  60
           +IS + AR  L   ++QV  D  P+ IT S++   V++S +DY+A QET YLLRSP+NAR
Sbjct  3   AISYTAARTNLAKTMDQVCEDRSPIIITRSKSQSVVMISLEDYEALQETAYLLRSPKNAR  62

Query  61  RLMEAVARDKAG  72
           RL+E+VA  + G
Sbjct  63  RLLESVAELEQG  74



Lambda     K      H
   0.314    0.127    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 

Effective search space used: 128725229700


  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Sep 5, 2011  4:36 AM
  Number of letters in database: 5,219,829,388
  Number of sequences in database:  15,229,318



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40