BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3382c Length=329 Score E Sequences producing significant alignments: (Bits) Value gi|15842974|ref|NP_338011.1| lytB protein [Mycobacterium tubercu... 655 0.0 gi|148824589|ref|YP_001289343.1| lytB-related protein lytB1 [Myc... 655 0.0 gi|289555658|ref|ZP_06444868.1| lytB-related protein lytB1 [Myco... 655 0.0 gi|340628361|ref|YP_004746813.1| putative LYTB-like protein LYTB... 649 0.0 gi|289747204|ref|ZP_06506582.1| lytB protein [Mycobacterium tube... 501 8e-140 gi|183980308|ref|YP_001848599.1| LytB-related protein LytB2 [Myc... 476 1e-132 gi|271965183|ref|YP_003339379.1| 4-hydroxy-3-methylbut-2-enyl di... 394 1e-107 gi|284032148|ref|YP_003382079.1| hydroxymethylbutenyl pyrophosph... 391 9e-107 gi|291299507|ref|YP_003510785.1| hydroxymethylbutenyl pyrophosph... 383 2e-104 gi|289763563|ref|ZP_06522941.1| lytB-related protein lytB1 [Myco... 378 7e-103 gi|336177213|ref|YP_004582588.1| 4-hydroxy-3-methylbut-2-enyl di... 368 8e-100 gi|256379028|ref|YP_003102688.1| hydroxymethylbutenyl pyrophosph... 365 5e-99 gi|312199709|ref|YP_004019770.1| hydroxymethylbutenyl pyrophosph... 363 2e-98 gi|111220888|ref|YP_711682.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4... 360 2e-97 gi|225791080|gb|ACO31284.1| PtmM1 [Streptomyces platensis] 359 3e-97 gi|86739537|ref|YP_479937.1| 4-hydroxy-3-methylbut-2-enyl diphos... 358 9e-97 gi|114777727|ref|ZP_01452687.1| 4-hydroxy-3-methylbut-2-enyl dip... 355 4e-96 gi|288922397|ref|ZP_06416587.1| hydroxymethylbutenyl pyrophospha... 355 6e-96 gi|158317460|ref|YP_001509968.1| hydroxymethylbutenyl pyrophosph... 353 2e-95 gi|291191892|gb|ADD82999.1| PtnM1 [Streptomyces platensis] 353 3e-95 gi|291298291|ref|YP_003509569.1| hydroxymethylbutenyl pyrophosph... 352 4e-95 gi|308048503|ref|YP_003912069.1| 4-hydroxy-3-methylbut-2-enyl di... 338 6e-91 gi|331697465|ref|YP_004333704.1| 4-hydroxy-3-methylbut-2-enyl di... 334 9e-90 gi|242238042|ref|YP_002986223.1| hydroxymethylbutenyl pyrophosph... 334 1e-89 gi|85712280|ref|ZP_01043331.1| 4-Hydroxy-3-methylbut-2-enyl diph... 333 2e-89 gi|290474749|ref|YP_003467629.1| 1-hydroxy-2-methyl-2-(E)-buteny... 333 3e-89 gi|333898943|ref|YP_004472816.1| 4-hydroxy-3-methylbut-2-enyl di... 332 3e-89 gi|339066431|ref|ZP_08649437.1| 4-hydroxy-3-methylbut-2-enyl dip... 332 3e-89 gi|329895219|ref|ZP_08270883.1| 4-hydroxy-3-methylbut-2-enyl dip... 332 4e-89 gi|251788191|ref|YP_003002912.1| hydroxymethylbutenyl pyrophosph... 332 5e-89 gi|338997877|ref|ZP_08636561.1| 4-hydroxy-3-methylbut-2-enyl dip... 332 6e-89 gi|253988040|ref|YP_003039396.1| 4-hydroxy-3-methylbut-2-enyl di... 332 7e-89 gi|271502095|ref|YP_003335121.1| hydroxymethylbutenyl pyrophosph... 331 8e-89 gi|299138493|ref|ZP_07031672.1| hydroxymethylbutenyl pyrophospha... 331 8e-89 gi|146305991|ref|YP_001186456.1| 4-hydroxy-3-methylbut-2-enyl di... 331 8e-89 gi|320540427|ref|ZP_08040077.1| 1-hydroxy-2-methyl-2-(E)-butenyl... 331 1e-88 gi|104783643|ref|YP_610141.1| 4-hydroxy-3-methylbut-2-enyl dipho... 331 1e-88 gi|330501958|ref|YP_004378827.1| 4-hydroxy-3-methylbut-2-enyl di... 330 2e-88 gi|327479532|gb|AEA82842.1| 4-hydroxy-3-methylbut-2-enyl diphosp... 330 2e-88 gi|157368946|ref|YP_001476935.1| 4-hydroxy-3-methylbut-2-enyl di... 330 2e-88 gi|307132644|ref|YP_003884660.1| 1-hydroxy-2-methyl-2-(E)-buteny... 330 2e-88 gi|192360516|ref|YP_001983668.1| 4-hydroxy-3-methylbut-2-enyl di... 330 2e-88 gi|343919306|gb|EGV30056.1| 4-hydroxy-3-methylbut-2-enyl diphosp... 330 2e-88 gi|88800789|ref|ZP_01116346.1| 4-hydroxy-3-methylbut-2-enyl diph... 330 2e-88 gi|339492946|ref|YP_004713239.1| 4-hydroxy-3-methylbut-2-enyl di... 330 3e-88 gi|170723717|ref|YP_001751405.1| 4-hydroxy-3-methylbut-2-enyl di... 330 3e-88 gi|152984227|ref|YP_001350529.1| 4-hydroxy-3-methylbut-2-enyl di... 329 3e-88 gi|90022208|ref|YP_528035.1| 4-hydroxy-3-methylbut-2-enyl diphos... 329 4e-88 gi|300724590|ref|YP_003713915.1| 1-hydroxy-2-methyl-2-(E)-buteny... 329 4e-88 gi|237801853|ref|ZP_04590314.1| 4-hydroxy-3-methylbut-2-enyl dip... 329 4e-88 >gi|15842974|ref|NP_338011.1| lytB protein [Mycobacterium tuberculosis CDC1551] gi|31794562|ref|NP_857055.1| LYTB-like protein LYTB1 [Mycobacterium bovis AF2122/97] gi|57117100|ref|YP_177967.1| LYTB-like protein LYTB1 [Mycobacterium tuberculosis H37Rv] 33 more sequence titles Length=329 Score = 655 bits (1691), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/329 (100%), Positives = 329/329 (100%), Gaps = 0/329 (0%) Query 1 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT Sbjct 1 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 Query 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV Sbjct 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 Query 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS Sbjct 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 Query 181 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 240 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS Sbjct 181 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 240 Query 241 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 300 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL Sbjct 241 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 300 Query 301 RGYASITVVERSIATETVRFGLPKQVRAQ 329 RGYASITVVERSIATETVRFGLPKQVRAQ Sbjct 301 RGYASITVVERSIATETVRFGLPKQVRAQ 329 >gi|148824589|ref|YP_001289343.1| lytB-related protein lytB1 [Mycobacterium tuberculosis F11] gi|167966942|ref|ZP_02549219.1| lytB-related protein lytB1 [Mycobacterium tuberculosis H37Ra] gi|253800428|ref|YP_003033429.1| lytB-related protein lytB1 [Mycobacterium tuberculosis KZN 1435] 17 more sequence titles Length=331 Score = 655 bits (1691), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/329 (100%), Positives = 329/329 (100%), Gaps = 0/329 (0%) Query 1 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT Sbjct 3 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 62 Query 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV Sbjct 63 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 122 Query 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS Sbjct 123 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 182 Query 181 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 240 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS Sbjct 183 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 242 Query 241 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 300 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL Sbjct 243 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 302 Query 301 RGYASITVVERSIATETVRFGLPKQVRAQ 329 RGYASITVVERSIATETVRFGLPKQVRAQ Sbjct 303 RGYASITVVERSIATETVRFGLPKQVRAQ 331 >gi|289555658|ref|ZP_06444868.1| lytB-related protein lytB1 [Mycobacterium tuberculosis KZN 605] gi|298526861|ref|ZP_07014270.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] gi|308232442|ref|ZP_07664083.1| lytB-related protein lytB1 [Mycobacterium tuberculosis SUMu001] 18 more sequence titles Length=335 Score = 655 bits (1690), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/329 (100%), Positives = 329/329 (100%), Gaps = 0/329 (0%) Query 1 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT Sbjct 7 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 66 Query 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV Sbjct 67 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 126 Query 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS Sbjct 127 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 186 Query 181 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 240 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS Sbjct 187 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 246 Query 241 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 300 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL Sbjct 247 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 306 Query 301 RGYASITVVERSIATETVRFGLPKQVRAQ 329 RGYASITVVERSIATETVRFGLPKQVRAQ Sbjct 307 RGYASITVVERSIATETVRFGLPKQVRAQ 335 >gi|340628361|ref|YP_004746813.1| putative LYTB-like protein LYTB1 [Mycobacterium canettii CIPT 140010059] gi|340006551|emb|CCC45737.1| putative LYTB-related protein LYTB1 [Mycobacterium canettii CIPT 140010059] Length=329 Score = 649 bits (1675), Expect = 0.0, Method: Compositional matrix adjust. Identities = 327/329 (99%), Positives = 327/329 (99%), Gaps = 0/329 (0%) Query 1 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 MAEVFVG VAQG ASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT Sbjct 1 MAEVFVGSVAQGCASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 Query 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV Sbjct 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 Query 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS Sbjct 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 Query 181 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 240 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS Sbjct 181 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 240 Query 241 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 300 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL Sbjct 241 CNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL 300 Query 301 RGYASITVVERSIATETVRFGLPKQVRAQ 329 RGYASITVVERSIATETVRFGLPKQVRAQ Sbjct 301 RGYASITVVERSIATETVRFGLPKQVRAQ 329 >gi|289747204|ref|ZP_06506582.1| lytB protein [Mycobacterium tuberculosis 02_1987] gi|289687732|gb|EFD55220.1| lytB protein [Mycobacterium tuberculosis 02_1987] Length=260 Score = 501 bits (1289), Expect = 8e-140, Method: Compositional matrix adjust. Identities = 251/251 (100%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT Sbjct 7 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 66 Query 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV Sbjct 67 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 126 Query 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS Sbjct 127 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 186 Query 181 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 240 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS Sbjct 187 YLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGS 246 Query 241 CNSSNSRRLVE 251 CNSSNSRRLVE Sbjct 247 CNSSNSRRLVE 257 >gi|183980308|ref|YP_001848599.1| LytB-related protein LytB2 [Mycobacterium marinum M] gi|183173634|gb|ACC38744.1| LytB-related protein LytB2 [Mycobacterium marinum M] Length=333 Score = 476 bits (1226), Expect = 1e-132, Method: Compositional matrix adjust. Identities = 236/313 (76%), Positives = 264/313 (85%), Gaps = 0/313 (0%) Query 15 SGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFV 74 S TVLLASPRSFCAGV RAIE V+RVLD A GPVYVRKQIVHN VVAEL+DRGA+FV Sbjct 19 SAATTVLLASPRSFCAGVHRAIEAVERVLDRATGPVYVRKQIVHNRTVVAELQDRGAIFV 78 Query 75 EDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARG 134 ++LDEIPDPP PGAVVVFSAHGVSPAVRA A+ RGL+VVDATCPLV KVHAEAARFA RG Sbjct 79 DELDEIPDPPAPGAVVVFSAHGVSPAVRAAANGRGLEVVDATCPLVTKVHAEAARFAGRG 138 Query 135 DTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 DTV+ IGH GHEET+GTLGVAP S LLVQ DV L+LPE Q+SYLTQTTLA+DET D Sbjct 139 DTVLLIGHLGHEETDGTLGVAPNSMLLVQNADDVTELDLPEDAQVSYLTQTTLAVDETTD 198 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 VIDALR RFP L +PP+EDICYATTNRQRA++++V CD +LV+GS NSSNS+RLVELA+ Sbjct 199 VIDALRKRFPKLAEPPTEDICYATTNRQRAVEAIVRRCDALLVVGSQNSSNSQRLVELAR 258 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 R GTPAYLIDGP DI+P WL S +TIG+TAGASAPPRLV QVIDALR I VVE + Sbjct 259 RRGTPAYLIDGPTDIDPHWLDSTATIGITAGASAPPRLVEQVIDALRLRGPINVVESPVT 318 Query 315 TETVRFGLPKQVR 327 TE+VRF LP +VR Sbjct 319 TESVRFALPPKVR 331 >gi|271965183|ref|YP_003339379.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Streptosporangium roseum DSM 43021] gi|270508358|gb|ACZ86636.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Streptosporangium roseum DSM 43021] Length=339 Score = 394 bits (1012), Expect = 1e-107, Method: Compositional matrix adjust. Identities = 214/324 (67%), Positives = 244/324 (76%), Gaps = 5/324 (1%) Query 7 GPVAQGYASGEV-TVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAE 65 GP G G V TVLLASPRS CAGVERAIETV+RVL PVYVRKQIVHN VVA+ Sbjct 18 GPPVGGLPDGSVRTVLLASPRSLCAGVERAIETVERVLADRGAPVYVRKQIVHNVHVVAD 77 Query 66 LRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHA 125 LR RGAVFVE+LDE+PD G VVFSAHGVSPAVRA A +GL+VVDATCPLV KVH Sbjct 78 LRRRGAVFVEELDEVPD----GETVVFSAHGVSPAVRAQAGRKGLRVVDATCPLVTKVHV 133 Query 126 EAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQT 185 EA RFAARGDTVV IGHAGHEE EGTLG APR ++LVQTPA+ AAL + + T++SYLTQT Sbjct 134 EARRFAARGDTVVLIGHAGHEEVEGTLGEAPRQSVLVQTPAEAAALEVDDPTRVSYLTQT 193 Query 186 TLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSN 245 TLA+DET++V++ALR RFP L P S+DICYATTNRQ A+ + D+VLV+GS NSSN Sbjct 194 TLAVDETSEVVEALRDRFPALSGPGSDDICYATTNRQHAVAGIAAAADLVLVVGSVNSSN 253 Query 246 SRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYAS 305 S RLVELA+R GTPA+LID IEP WL IG++AGASAP LV +VI LRG Sbjct 254 SVRLVELARRQGTPAHLIDDAGGIEPGWLHGARVIGLSAGASAPHHLVEEVIAFLRGLGP 313 Query 306 ITVVERSIATETVRFGLPKQVRAQ 329 + V E TETVRF PK+VR Sbjct 314 LRVREHRHTTETVRFAPPKEVRTN 337 >gi|284032148|ref|YP_003382079.1| hydroxymethylbutenyl pyrophosphate reductase [Kribbella flavida DSM 17836] gi|283811441|gb|ADB33280.1| hydroxymethylbutenyl pyrophosphate reductase [Kribbella flavida DSM 17836] Length=334 Score = 391 bits (1004), Expect = 9e-107, Method: Compositional matrix adjust. Identities = 206/310 (67%), Positives = 239/310 (78%), Gaps = 4/310 (1%) Query 19 TVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLD 78 T+LLASPRSFCAGVERAIE V+++L PVYVRKQIVHNT VVA+L RGAVFV++LD Sbjct 5 TILLASPRSFCAGVERAIEIVEQLLARRRSPVYVRKQIVHNTHVVADLESRGAVFVDELD 64 Query 79 EIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVV 138 E+P A VVFSAHGV+PAVRA A+ RGL VVDATCPLV KVHAEA R+A RGDTVV Sbjct 65 EVP----ADATVVFSAHGVAPAVRAEAERRGLDVVDATCPLVTKVHAEARRYAGRGDTVV 120 Query 139 FIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDA 198 IGHAGHEE EGT+G AP T+LV+T DVAAL + + ++SYLTQTTLA+DETA V+DA Sbjct 121 LIGHAGHEEVEGTMGEAPDRTVLVETVDDVAALEVEDAGRVSYLTQTTLAVDETAAVLDA 180 Query 199 LRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGT 258 LRA+F L P S DICYATTNRQ AL ++ + D+VLV+GS NSSNSRRLVELA+R GT Sbjct 181 LRAKFGALRGPDSADICYATTNRQEALGALSDDADLVLVVGSDNSSNSRRLVELARRRGT 240 Query 259 PAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETV 318 PAYLID + PEWL V IG+TAGASAPPRLV V+ AL + + VVER I ETV Sbjct 241 PAYLIDDGSGLRPEWLDGVRVIGLTAGASAPPRLVDGVVAALAAFGPVDVVEREITRETV 300 Query 319 RFGLPKQVRA 328 F LP VR+ Sbjct 301 HFTLPVAVRS 310 >gi|291299507|ref|YP_003510785.1| hydroxymethylbutenyl pyrophosphate reductase [Stackebrandtia nassauensis DSM 44728] gi|290568727|gb|ADD41692.1| hydroxymethylbutenyl pyrophosphate reductase [Stackebrandtia nassauensis DSM 44728] Length=422 Score = 383 bits (984), Expect = 2e-104, Method: Compositional matrix adjust. Identities = 196/309 (64%), Positives = 239/309 (78%), Gaps = 4/309 (1%) Query 19 TVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLD 78 TVLLASPRS+CAGVERAIE V+R L+ PVYVRKQIVHN VVAEL RGAVFV++LD Sbjct 118 TVLLASPRSYCAGVERAIEVVERALERHGQPVYVRKQIVHNAHVVAELEKRGAVFVDELD 177 Query 79 EIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVV 138 ++PD GA V+FSAHGVSPAVR AD RGL +DATCPLV KVHAEA RFA RGDTVV Sbjct 178 QVPD----GATVIFSAHGVSPAVRDDADSRGLAAIDATCPLVTKVHAEARRFADRGDTVV 233 Query 139 FIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDA 198 IGH GHEE EGT+G AP S +LV++ ADV L +P+ +L+YLTQTTLA++ET ++I A Sbjct 234 LIGHDGHEEVEGTMGEAPESMVLVESVADVERLRVPDPRRLAYLTQTTLAVEETEEIIAA 293 Query 199 LRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGT 258 LRARFP L P S+DICYATTNRQ A+ ++V +CD+VLV+GS NSSNSRRLVELA+R G Sbjct 294 LRARFPALRGPGSDDICYATTNRQHAVAAIVDDCDLVLVVGSANSSNSRRLVELAERHGR 353 Query 259 PAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETV 318 A LID +DIE +WL+ T+G++AGASAP L+ +V++ L G+ I VVER + E Sbjct 354 MARLIDSAEDIELDWLTGADTVGLSAGASAPQILMDEVVETLAGFGPIDVVERVVTAEDQ 413 Query 319 RFGLPKQVR 327 F LP++VR Sbjct 414 SFVLPREVR 422 >gi|289763563|ref|ZP_06522941.1| lytB-related protein lytB1 [Mycobacterium tuberculosis GM 1503] gi|289711069|gb|EFD75085.1| lytB-related protein lytB1 [Mycobacterium tuberculosis GM 1503] Length=238 Score = 378 bits (970), Expect = 7e-103, Method: Compositional matrix adjust. Identities = 194/210 (93%), Positives = 195/210 (93%), Gaps = 0/210 (0%) Query 1 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 60 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT Sbjct 3 MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNT 62 Query 61 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 120 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV Sbjct 63 VVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLV 122 Query 121 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 180 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS Sbjct 123 AKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLS 182 Query 181 YLTQTTLALDETADVIDALRARFPTLGQPP 210 YLTQTTLALDE + F PP Sbjct 183 YLTQTTLALDELPMSLMRCARGFRRWANPP 212 >gi|336177213|ref|YP_004582588.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Frankia symbiont of Datisca glomerata] gi|334858193|gb|AEH08667.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Frankia symbiont of Datisca glomerata] Length=547 Score = 368 bits (944), Expect = 8e-100, Method: Compositional matrix adjust. Identities = 190/323 (59%), Positives = 239/323 (74%), Gaps = 6/323 (1%) Query 7 GPVAQGYAS--GEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVA 64 GPV + +A+ G VLLA PR+FCAGVERAIE V+R L++ PVYVRKQIVHN+ VVA Sbjct 225 GPVLERWAAAVGPRQVLLAEPRAFCAGVERAIEVVERALELHGAPVYVRKQIVHNSHVVA 284 Query 65 ELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVH 124 +L RGAVFVE+LDE+P PGA VVFSAHGV+PAV A +R L V+DATCPLV KVH Sbjct 285 DLASRGAVFVEELDEVP----PGATVVFSAHGVAPAVWDQAGDRNLSVIDATCPLVEKVH 340 Query 125 AEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQ 184 AEA RF ARGDTV+ IGHAGHEE +GTLG AP LV++PADVA L + + +++YL Q Sbjct 341 AEARRFTARGDTVLLIGHAGHEEVDGTLGEAPGKIKLVESPADVAHLEVDDPQRVTYLMQ 400 Query 185 TTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSS 244 TTLA+DE +V+DALR RFP + P S DICYAT+NRQ A++ + E DVVLV+GS NS+ Sbjct 401 TTLAVDEAEEVVDALRDRFPAVIGPGSADICYATSNRQNAIRRVAVEADVVLVVGSQNSA 460 Query 245 NSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYA 304 NSRRLV++ +R G PAYL+ ++E WL+ T+G++AGASAPP LV ++ AL G Sbjct 461 NSRRLVDVTEREGVPAYLVGDVGEVEMNWLAGADTVGISAGASAPPTLVDELTRALSGLG 520 Query 305 SITVVERSIATETVRFGLPKQVR 327 TV RS+ ET+ F LPK++R Sbjct 521 HTTVGVRSVGAETISFHLPKELR 543 >gi|256379028|ref|YP_003102688.1| hydroxymethylbutenyl pyrophosphate reductase [Actinosynnema mirum DSM 43827] gi|255923331|gb|ACU38842.1| hydroxymethylbutenyl pyrophosphate reductase [Actinosynnema mirum DSM 43827] Length=307 Score = 365 bits (937), Expect = 5e-99, Method: Compositional matrix adjust. Identities = 194/308 (63%), Positives = 225/308 (74%), Gaps = 7/308 (2%) Query 20 VLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDE 79 VLLASPRSFCAGVERA+E V+ +L GPV+VRKQIVHNT VVA L GAVFV++LDE Sbjct 6 VLLASPRSFCAGVERAVEIVEELLRRRGGPVHVRKQIVHNTHVVARLESMGAVFVDELDE 65 Query 80 IPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVF 139 +PD GAVVVFSAHGVSPAVRA A+ RG +VVDATCPLV KVHAEA RFA RGDTVV Sbjct 66 VPD----GAVVVFSAHGVSPAVRAEAERRGFEVVDATCPLVTKVHAEARRFAGRGDTVVL 121 Query 140 IGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDAL 199 IGHAGHEE EGTLG AP LLV P VAAL + + ++SYL QTTLA DE +V+ AL Sbjct 122 IGHAGHEEVEGTLGEAPDRMLLVDGPEAVAALEVEDPERVSYLMQTTLAADEATEVVAAL 181 Query 200 RARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTP 259 R RFP L P S+DICYATTNRQ A++ + E D+VLV+GS NSSNS RLVEL +R G P Sbjct 182 RKRFPALRGPSSDDICYATTNRQEAVREVAREADLVLVVGSANSSNSARLVELVRREGVP 241 Query 260 AYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVR 319 A+LID D+ P WL V +G++AGASAPP LV +V+ L + V R ET+R Sbjct 242 AHLIDDVRDLRPRWLEGVRVVGLSAGASAPPGLVDEVVAVLDAH---RVEVRETTVETIR 298 Query 320 FGLPKQVR 327 F LP VR Sbjct 299 FTLPAAVR 306 >gi|312199709|ref|YP_004019770.1| hydroxymethylbutenyl pyrophosphate reductase [Frankia sp. EuI1c] gi|311231045|gb|ADP83900.1| hydroxymethylbutenyl pyrophosphate reductase [Frankia sp. EuI1c] Length=571 Score = 363 bits (931), Expect = 2e-98, Method: Compositional matrix adjust. Identities = 187/322 (59%), Positives = 239/322 (75%), Gaps = 5/322 (1%) Query 7 GPV-AQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAE 65 GP+ A A G+ VLLA PR+FCAGVERAIE V+R L++ PVYVRKQIVHNT VV + Sbjct 249 GPLGAWAAAVGQRRVLLAEPRAFCAGVERAIEVVERALELHGAPVYVRKQIVHNTHVVND 308 Query 66 LRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHA 125 L RGAVFV++LDE+P PGA VVFSAHGV+PAV A R L V+DATCPLV KVHA Sbjct 309 LASRGAVFVDELDEVP----PGATVVFSAHGVAPAVHVEAAGRNLDVIDATCPLVEKVHA 364 Query 126 EAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQT 185 EA RF ARGDTV+ IGHAGHEE +GTLG AP LV++ DV +L + + +++YL QT Sbjct 365 EARRFTARGDTVLLIGHAGHEEVDGTLGEAPGRITLVESAEDVPSLQVEDPERVTYLMQT 424 Query 186 TLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSN 245 TLA+DE +V+DAL+ARFP + P S DICYAT+NRQ A++ + E D+VLV+GS NS+N Sbjct 425 TLAVDEAEEVVDALKARFPAIVGPGSADICYATSNRQNAVRRVASEADLVLVVGSENSAN 484 Query 246 SRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYAS 305 SRRL E+A+R G ++L++ D++ +WL+ TIG++AGASAPP LV ++ DAL G + Sbjct 485 SRRLAEVARRDGVASHLVESVDEVRLDWLAGADTIGISAGASAPPSLVHELADALAGLGA 544 Query 306 ITVVERSIATETVRFGLPKQVR 327 TV RSI TE++ F LPK+VR Sbjct 545 TTVTTRSIGTESIAFTLPKEVR 566 >gi|111220888|ref|YP_711682.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein [Frankia alni ACN14a] gi|111148420|emb|CAJ60091.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein (partial match) [Frankia alni ACN14a] Length=597 Score = 360 bits (924), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 184/318 (58%), Positives = 235/318 (74%), Gaps = 4/318 (1%) Query 10 AQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDR 69 A A G TVLLA PR+FCAGVERAIE V+R L++ PVYVRKQIVHN+ VVA+L R Sbjct 256 AWAAAVGRRTVLLAEPRAFCAGVERAIEVVERALELHGAPVYVRKQIVHNSHVVADLAAR 315 Query 70 GAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAAR 129 GAVFVE+LDE+P GA VVFSAHGV+PAV AD R L V+DATCPLV KVHAEA R Sbjct 316 GAVFVEELDEVP----AGATVVFSAHGVAPAVWNQADGRQLSVIDATCPLVEKVHAEARR 371 Query 130 FAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLAL 189 F +RGDTV+ IGH+GHEE +GTLG AP LVQ+P +V AL++P+ +++YL QTTLA+ Sbjct 372 FTSRGDTVLLIGHSGHEEVDGTLGEAPGRIRLVQSPEEVDALDVPDPERVTYLMQTTLAM 431 Query 190 DETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRL 249 DE +V+DAL+ RFP + P S DICYAT+NRQ A++ + E +VLV+GS NS+NS RL Sbjct 432 DEAEEVVDALKERFPAIVGPGSADICYATSNRQNAVRKVAQEAQLVLVVGSANSANSVRL 491 Query 250 VELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVV 309 VE+++R G ++L++ D+E WL V T+G++AGASAPP LV ++ AL G + V Sbjct 492 VEVSRRDGVASHLVENVGDVELSWLDGVETVGISAGASAPPSLVEELTAALSGLGATDVT 551 Query 310 ERSIATETVRFGLPKQVR 327 RS+ TETV F LPK++R Sbjct 552 TRSVGTETVAFHLPKELR 569 >gi|225791080|gb|ACO31284.1| PtmM1 [Streptomyces platensis] Length=448 Score = 359 bits (922), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 186/315 (60%), Positives = 229/315 (73%), Gaps = 4/315 (1%) Query 14 ASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVF 73 A G+ V LA+PRSFCAGV+RAIE V+R LD PVYVRKQIVHN VV +L RGAVF Sbjct 121 AKGDRAVALAAPRSFCAGVDRAIEIVERALDQYGAPVYVRKQIVHNRHVVEDLARRGAVF 180 Query 74 VEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAAR 133 VE+LDE+P+ G +VVFSAHGV+PAVR A ER L+V+DATCPLV KVHAEA RFA R Sbjct 181 VEELDEVPE----GELVVFSAHGVAPAVRDAAGERDLRVIDATCPLVTKVHAEAKRFAGR 236 Query 134 GDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 GDTVV IGHAGHEE EGTLG AP T+LVQ + A L + + +S+L QTTLA+ E Sbjct 237 GDTVVLIGHAGHEEVEGTLGEAPDRTVLVQNAVEAARLEVEDPEAVSFLMQTTLAMSEAT 296 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 +V +AL RFP++ P SEDICYA+TNRQRA++ + G D++LV+GS NSSNS RL ELA Sbjct 297 EVAEALAGRFPSIKAPQSEDICYASTNRQRAVEEIAGRVDLLLVVGSPNSSNSVRLKELA 356 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPA L+D D+ E L IG+TAGASAP LV +++ LR ++TV E + Sbjct 357 ERMGTPAQLVDDASDVVLEQLHGARRIGLTAGASAPDALVQEIVANLRALGTVTVTEHQV 416 Query 314 ATETVRFGLPKQVRA 328 ATE V F LPK++R+ Sbjct 417 ATENVTFQLPKELRS 431 >gi|86739537|ref|YP_479937.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Frankia sp. CcI3] gi|86566399|gb|ABD10208.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Frankia sp. CcI3] Length=497 Score = 358 bits (918), Expect = 9e-97, Method: Compositional matrix adjust. Identities = 183/318 (58%), Positives = 233/318 (74%), Gaps = 4/318 (1%) Query 10 AQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDR 69 A A G VLLA PR+FCAGVERAIE V+R L++ PVYVRKQIVHN VVA+L R Sbjct 174 AWAAAVGRRQVLLAEPRAFCAGVERAIEVVERALEIYGAPVYVRKQIVHNAHVVADLASR 233 Query 70 GAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAAR 129 GA+FVE+LDE+P G+ VVFSAHGV+PAV A ERGL V+DATCPLV KVH EA R Sbjct 234 GAIFVEELDEVPG----GSTVVFSAHGVAPAVWDQAGERGLSVIDATCPLVEKVHTEARR 289 Query 130 FAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLAL 189 F ARGDTV+ IGH+GHEE +GTLG AP LV++ ADV +L++P+ +++YL QTTLAL Sbjct 290 FTARGDTVLLIGHSGHEEVDGTLGEAPGRITLVESSADVGSLDVPDPERVTYLMQTTLAL 349 Query 190 DETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRL 249 DE A+V+DAL RFP + P S DICYAT+NRQ A++ + E +VLV+GS NS+NS RL Sbjct 350 DEAAEVVDALTERFPAIVGPGSTDICYATSNRQNAVRKVAEEAQLVLVVGSANSANSVRL 409 Query 250 VELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVV 309 VE+++R G A+L+ D+ WL+ V TIG++AGASAPP LV +++ AL G + V Sbjct 410 VEVSRRDGVEAHLVGDVGDVHLSWLAGVDTIGISAGASAPPSLVNELLTALSGLGATDVS 469 Query 310 ERSIATETVRFGLPKQVR 327 RS+ TET+ F LPK++R Sbjct 470 VRSVGTETLAFHLPKELR 487 >gi|114777727|ref|ZP_01452687.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Mariprofundus ferrooxydans PV-1] gi|114551943|gb|EAU54477.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Mariprofundus ferrooxydans PV-1] Length=319 Score = 355 bits (912), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 186/312 (60%), Positives = 232/312 (75%), Gaps = 9/312 (2%) Query 19 TVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLD 78 TV+LA PR FCAGV+RAIE V+R L V PVYVR +IVHN VV +L+ +GAVF+E++D Sbjct 14 TVILAEPRGFCAGVDRAIEIVERSLAVYGAPVYVRHEIVHNRYVVQDLQAKGAVFIEEVD 73 Query 79 EIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVV 138 + PD GA+++FSAHGVS AVR AD RGL+V+DATCPLV KVH E R RGD V+ Sbjct 74 DAPD----GALLIFSAHGVSKAVRESADRRGLRVIDATCPLVTKVHLELLRHYQRGDQVI 129 Query 139 FIGHAGHEETEGTLGVAPR-STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVID 197 IGHAGH E EGT+G AP + LLV TPADV AL + + +L+Y+TQTTL++D+TADVID Sbjct 130 LIGHAGHPEVEGTMGQAPAGAVLLVATPADVEALQVKDPARLAYVTQTTLSVDDTADVID 189 Query 198 ALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSG 257 ALR RFP L P EDICYAT+NRQ A + + DVVLVIGS NSSNS RL E+A+RSG Sbjct 190 ALRRRFPLLQGPKREDICYATSNRQAATKELAKASDVVLVIGSKNSSNSNRLREVAERSG 249 Query 258 TPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDAL--RGYASITVVERSIAT 315 + A+LIDGP+DI+P+WL+ + IG+TAGASAP LV VI L RGYA + V+ ++ Sbjct 250 SAAWLIDGPEDIDPDWLTPDARIGITAGASAPEVLVNSVIAWLQARGYAGVEVL--VVSE 307 Query 316 ETVRFGLPKQVR 327 E V F LP+Q+R Sbjct 308 ENVTFSLPEQLR 319 >gi|288922397|ref|ZP_06416587.1| hydroxymethylbutenyl pyrophosphate reductase [Frankia sp. EUN1f] gi|288346268|gb|EFC80607.1| hydroxymethylbutenyl pyrophosphate reductase [Frankia sp. EUN1f] Length=631 Score = 355 bits (911), Expect = 6e-96, Method: Compositional matrix adjust. Identities = 185/324 (58%), Positives = 235/324 (73%), Gaps = 6/324 (1%) Query 6 VGPVAQGY--ASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVV 63 +GP + + A +LLA PR+FCAGVERAIE V+R L++ PVYVRKQIVHNT VV Sbjct 305 LGPALRAWVDAVANRRLLLAEPRAFCAGVERAIEVVERALELHGAPVYVRKQIVHNTHVV 364 Query 64 AELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKV 123 A+L RGAVFVE+LDE+P GA VVFSAHGV+PAV A +RGL V+DATCPLV KV Sbjct 365 ADLAGRGAVFVEELDEVP----AGATVVFSAHGVAPAVWDQAGDRGLDVIDATCPLVEKV 420 Query 124 HAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLT 183 HAEA RF ARGDTV+ IGHAGHEE EGTLG P LV++P V L + + +++YL Sbjct 421 HAEARRFTARGDTVLLIGHAGHEEVEGTLGEVPGRIQLVESPEAVKDLQVDDPERVTYLM 480 Query 184 QTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNS 243 QTTLA+DE +V+DALR RFP + P S DICYAT+NRQ A++ + E D+VLV+GS NS Sbjct 481 QTTLAVDEAEEVVDALRVRFPAVVGPGSADICYATSNRQNAVRRVAAEADLVLVVGSENS 540 Query 244 SNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGY 303 SNS+RLVE+++R G A+L++ D++ EWL TIG++AGASAPP LV ++ AL G Sbjct 541 SNSKRLVEVSERDGVAAHLVESVGDVQLEWLRGARTIGISAGASAPPLLVEELTAALSGL 600 Query 304 ASITVVERSIATETVRFGLPKQVR 327 S +V RS+ E++ F LPK+VR Sbjct 601 GSASVTVRSVGAESISFHLPKEVR 624 >gi|158317460|ref|YP_001509968.1| hydroxymethylbutenyl pyrophosphate reductase [Frankia sp. EAN1pec] gi|158112865|gb|ABW15062.1| hydroxymethylbutenyl pyrophosphate reductase [Frankia sp. EAN1pec] Length=657 Score = 353 bits (906), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 179/308 (59%), Positives = 233/308 (76%), Gaps = 4/308 (1%) Query 20 VLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDE 79 +LLA PR+FCAGVERAIE V+R L++ PVYVRKQIVHNT VVA+L RGAVFVE+LDE Sbjct 347 LLLAEPRAFCAGVERAIEVVERALEIHGAPVYVRKQIVHNTHVVADLASRGAVFVEELDE 406 Query 80 IPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVF 139 +P PGA VVFSAHGV+PA+ A ER L V+DATCPLV KVHAEA RF ARGDTV+ Sbjct 407 VP----PGATVVFSAHGVAPAIWDEAGERDLAVIDATCPLVEKVHAEARRFTARGDTVLL 462 Query 140 IGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDAL 199 IGH+GHEE +GTLG AP LV++ A V + + + +++YL QTTLA+DE +V+DAL Sbjct 463 IGHSGHEEVDGTLGEAPGRIQLVESAAAVEDIEVADPERVTYLMQTTLAVDEAEEVVDAL 522 Query 200 RARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTP 259 R RFP + P S DICYAT+NRQ A++ + E ++VLV+GS NSSNSRRLVE+++R G Sbjct 523 RDRFPAVVGPGSADICYATSNRQNAVRRVAAEAELVLVVGSENSSNSRRLVEVSERDGVA 582 Query 260 AYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVR 319 A+L++ +D++ +WL V T+G++AGASAPP LV ++ AL G S +V RS+ +E++ Sbjct 583 AHLVESVEDVQLDWLKGVRTVGISAGASAPPLLVEELTAALSGLGSASVSVRSVGSESIS 642 Query 320 FGLPKQVR 327 F LPK+VR Sbjct 643 FHLPKEVR 650 >gi|291191892|gb|ADD82999.1| PtnM1 [Streptomyces platensis] Length=448 Score = 353 bits (905), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 186/315 (60%), Positives = 226/315 (72%), Gaps = 4/315 (1%) Query 14 ASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVF 73 A G+ V LA+PRSFCAGV+RAIE V+R LD PVYVRKQIVHN VV +L RGAVF Sbjct 121 AKGDREVALAAPRSFCAGVDRAIEIVERALDRYGAPVYVRKQIVHNRHVVEDLARRGAVF 180 Query 74 VEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAAR 133 VE+LDE+P+ P VVFSAHGV+PAVR A RGL+V+DATCPLV KVHAEA RFA R Sbjct 181 VEELDEVPEGEP----VVFSAHGVAPAVRDAAAGRGLRVIDATCPLVTKVHAEAKRFAGR 236 Query 134 GDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 GDTVV IGHAGHEE EGTLG AP T+LVQ A+ A L + + +S+L QTTLA+ E Sbjct 237 GDTVVLIGHAGHEEVEGTLGEAPDRTVLVQNAAEAARLEVEDPEAVSFLMQTTLAMSEAT 296 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 +V AL RFP++ P SEDICYA+TNRQRA++ + G D++LV+GS NSSNS RL ELA Sbjct 297 EVAQALAGRFPSIRAPRSEDICYASTNRQRAVEEIAGRVDLLLVVGSPNSSNSVRLKELA 356 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPA L+D + E L IG+TAGASAP LV +++ LR +TV E + Sbjct 357 ERMGTPAQLVDDVSYVGLEQLRGARRIGLTAGASAPDTLVQEIVANLRALGPVTVTEHQV 416 Query 314 ATETVRFGLPKQVRA 328 ATE V F LPK++R+ Sbjct 417 ATENVTFQLPKELRS 431 >gi|291298291|ref|YP_003509569.1| hydroxymethylbutenyl pyrophosphate reductase [Stackebrandtia nassauensis DSM 44728] gi|290567511|gb|ADD40476.1| hydroxymethylbutenyl pyrophosphate reductase [Stackebrandtia nassauensis DSM 44728] Length=478 Score = 352 bits (904), Expect = 4e-95, Method: Compositional matrix adjust. Identities = 185/309 (60%), Positives = 228/309 (74%), Gaps = 5/309 (1%) Query 19 TVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLD 78 TV+LASPRSFCAGVERAIE V+ L+ P+YVRKQIVHNT VVA L GA+FV+DLD Sbjct 7 TVVLASPRSFCAGVERAIEIVELALERFGAPIYVRKQIVHNTHVVARLEGEGAIFVDDLD 66 Query 79 EIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVV 138 +PD GA VVFSAHGV+P+VRA A+ RGL V+DATCPLVAKVH EA RFA RGDT++ Sbjct 67 AVPD----GACVVFSAHGVAPSVRAEAESRGLDVIDATCPLVAKVHTEARRFAERGDTIL 122 Query 139 FIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDA 198 IGH+GHEE EGT+G A LV++ ADV +L + + ++++YLTQTTL++DETA++I A Sbjct 123 LIGHSGHEEVEGTMGEAA-GIRLVESLADVDSLTVEDPSKVAYLTQTTLSVDETAEIIAA 181 Query 199 LRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGT 258 LR RFP L P +DICYAT+NRQ A+ + E D+VLV+GS NSSNSRRL E+A +GT Sbjct 182 LRRRFPKLRGPGGDDICYATSNRQEAIVEVAREADLVLVVGSRNSSNSRRLTEVAATAGT 241 Query 259 PAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETV 318 PA+LI+ I EWL+ IG++AGASAPP LV VI LRG+ +TV ER E V Sbjct 242 PAHLIEDAGQIRTEWLTGARVIGLSAGASAPPHLVEAVIAHLRGFGPVTVTERHTVEENV 301 Query 319 RFGLPKQVR 327 F LP VR Sbjct 302 TFSLPLVVR 310 >gi|308048503|ref|YP_003912069.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Ferrimonas balearica DSM 9799] gi|307630693|gb|ADN74995.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Ferrimonas balearica DSM 9799] Length=309 Score = 338 bits (867), Expect = 6e-91, Method: Compositional matrix adjust. Identities = 174/313 (56%), Positives = 223/313 (72%), Gaps = 7/313 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + VLLA+PR FCAGV+RAI V+R L++ E P+YVR ++VHN VV LR RGAVFV++L Sbjct 1 MKVLLANPRGFCAGVDRAISIVERALELFEKPIYVRHEVVHNRYVVDGLRQRGAVFVDEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 E+PD A+V+FSAHGVS VR A +RGL+V DATCPLV KVH + R + +G Sbjct 61 HEVPD----NAIVIFSAHGVSQQVREEAKDRGLKVFDATCPLVTKVHMQVTRASRKGIEC 116 Query 138 VFIGHAGHEETEGTLGV---APRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 V IGHAGH E EGT+G A LV++P DVAA+ + + L+++TQTTL++D+TA+ Sbjct 117 VLIGHAGHPEVEGTMGQYDNADGGIYLVESPEDVAAMQVKDERNLTFVTQTTLSMDDTAE 176 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 VIDAL+ RFP + P +DICYAT NRQ A++ + +CD VLV+GS NSSNS RL ELAQ Sbjct 177 VIDALKRRFPEVEGPRKDDICYATQNRQDAVRELALQCDRVLVVGSKNSSNSNRLRELAQ 236 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 +SGTPAYLIDG +DI+PEWL + IGVTAGASAP LV VIDAL+ + V E S Sbjct 237 KSGTPAYLIDGAEDIQPEWLEGAARIGVTAGASAPEVLVQGVIDALKQQGAEAVEEASGR 296 Query 315 TETVRFGLPKQVR 327 E V F +P ++R Sbjct 297 EENVVFHVPAELR 309 >gi|331697465|ref|YP_004333704.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudonocardia dioxanivorans CB1190] gi|326952154|gb|AEA25851.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudonocardia dioxanivorans CB1190] Length=509 Score = 334 bits (857), Expect = 9e-90, Method: Compositional matrix adjust. Identities = 173/313 (56%), Positives = 221/313 (71%), Gaps = 4/313 (1%) Query 14 ASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVF 73 A+G TV LA PRSFCAGVERAIE V R LD PVYVR+QIVHN VV L DRGAVF Sbjct 199 ATGPRTVRLAEPRSFCAGVERAIEIVDRALDRYGAPVYVRRQIVHNAHVVRRLTDRGAVF 258 Query 74 VEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAAR 133 V+++DE+P PGA VV +AHGVSPAVRA AD RGL VVDATCPLVAKVH E R A R Sbjct 259 VQEVDEVP----PGAHVVLAAHGVSPAVRADADARGLSVVDATCPLVAKVHTEVRRHARR 314 Query 134 GDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 G++V+ IGH+ HEE EGT+G AP +V+ + +P+ T+++Y QTTLA+DE Sbjct 315 GESVLLIGHSDHEEVEGTVGEAPARVTVVEDEESARTVEVPDPTRVAYAMQTTLAVDEAE 374 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 + LR RFP++ P +DICYATTNRQRA++++ + D+V+V+GS NSSNSRRL E+A Sbjct 375 RIAAILRERFPSIAAPRQDDICYATTNRQRAIRAVSADVDLVIVVGSPNSSNSRRLAEVA 434 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 R G PA+L+D +++ WL+ V +G++AGASAP LV +V+ L G +TV S Sbjct 435 ARQGVPAHLVDDVSELDLSWLAGVGRVGLSAGASAPDDLVDEVVSCLSGLGPVTVTATST 494 Query 314 ATETVRFGLPKQV 326 +E VRF LPK+V Sbjct 495 GSEHVRFTLPKEV 507 >gi|242238042|ref|YP_002986223.1| hydroxymethylbutenyl pyrophosphate reductase [Dickeya dadantii Ech703] gi|242130099|gb|ACS84401.1| hydroxymethylbutenyl pyrophosphate reductase [Dickeya dadantii Ech703] Length=316 Score = 334 bits (856), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 169/315 (54%), Positives = 221/315 (71%), Gaps = 7/315 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L+V P+YVR ++VHN VV LR+RGA+F+E + Sbjct 1 MKILLANPRGFCAGVDRAISIVERALEVYGAPIYVRHEVVHNRYVVDGLRERGAIFIEQI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 DE+PD GA+++FSAHGVS AVRA A R L V DATCPLV KVH E AR + +G Sbjct 61 DEVPD----GAILIFSAHGVSQAVRAEARNRDLTVFDATCPLVTKVHMEVARASRKGMEA 116 Query 138 VFIGHAGHEETEGTLG--VAPRSTL-LVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 + IGHAGH E EGT+G P+ + LV+ P DV +L + T L ++TQTTL++D+T+ Sbjct 117 ILIGHAGHPEVEGTMGQYSNPKGGMYLVEGPDDVWSLQVKNETNLCFMTQTTLSVDDTSA 176 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 VIDALRARFP + P +DICYATTNRQ A++++ E DVVLV+GS NSSNS RL ELAQ Sbjct 177 VIDALRARFPQIIGPRKDDICYATTNRQEAVRNLAQEADVVLVVGSKNSSNSNRLAELAQ 236 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 R G P+YLID DDI+ W S + +GVTAGASAP LV QV+ L+G +E Sbjct 237 RVGKPSYLIDSADDIQESWFSRTACVGVTAGASAPDVLVQQVVKRLQGMGGQIALEMQGR 296 Query 315 TETVRFGLPKQVRAQ 329 E++ F +PK++R + Sbjct 297 EESIVFEVPKELRVE 311 >gi|85712280|ref|ZP_01043331.1| 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase [Idiomarina baltica OS145] gi|85693907|gb|EAQ31854.1| 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase [Idiomarina baltica OS145] Length=309 Score = 333 bits (854), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 165/313 (53%), Positives = 220/313 (71%), Gaps = 7/313 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L++ E P+YVR ++VHN VV +LRD GAVFVE+L Sbjct 1 MQILLANPRGFCAGVDRAITIVERALEIFEPPIYVRHEVVHNKYVVNKLRDAGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 DE+PD A+V+FSAHGVS AVR A +RGL+V DATCPLV KVH E R + +G Sbjct 61 DEVPDE----AIVIFSAHGVSQAVRQNAKDRGLKVFDATCPLVTKVHMEVTRASRKGHEC 116 Query 138 VFIGHAGHEETEGTLG--VAPRSTL-LVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 V IGHAGH E EGT+G P+ + LV++P DV L + + L Y++QTTL++D+TAD Sbjct 117 VLIGHAGHPEVEGTMGQYANPKGGIYLVESPEDVGTLEIKDPNNLHYMSQTTLSVDDTAD 176 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 VIDALR RFP + P +DICYAT NRQ A++ + E ++LV+G+ NSSNS RL EL++ Sbjct 177 VIDALRQRFPNINGPRKDDICYATQNRQDAVRQLAEEAQLMLVVGAKNSSNSNRLRELSE 236 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 + GTPAYLID + I+ EWL+ + + VTAGASAP LV +VI+ L+ + TV ER Sbjct 237 KMGTPAYLIDDANGIQREWLNDIDRVAVTAGASAPEVLVREVIEQLKTWGGKTVSERQGR 296 Query 315 TETVRFGLPKQVR 327 E + F +P +R Sbjct 297 EENITFSIPPDLR 309 >gi|290474749|ref|YP_003467629.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase [Xenorhabdus bovienii SS-2004] gi|289174062|emb|CBJ80849.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein [Xenorhabdus bovienii SS-2004] Length=317 Score = 333 bits (853), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 167/316 (53%), Positives = 220/316 (70%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L++ P+YVR ++VHN VV LR+RGA+F+E++ Sbjct 1 MQILLANPRGFCAGVDRAISIVERALELYGAPIYVRHEVVHNRYVVDNLRERGAIFIENI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVV-DATCPLVAKVHAEAARFAARGDT 136 E+PD GA+++FSAHGVS A+RA A R L ++ DATCPLV KVH E AR + +G Sbjct 61 AEVPD----GAILIFSAHGVSQAIRAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKE 116 Query 137 VVFIGHAGHEETEGTLGVAPR---STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G LV++PADV L + + L ++TQTTL++D+T+ Sbjct 117 AILIGHAGHPEVEGTMGQYNNPEGGMYLVESPADVWKLQVKDENNLCFMTQTTLSVDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 +VIDAL ARFP + P +DICYATTNRQ A++ + DVVLV+GS NSSNS RL ELA Sbjct 177 EVIDALNARFPNIVGPRKDDICYATTNRQEAVRDLASGADVVLVVGSKNSSNSNRLAELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 QR G PAYLID DDI+ EW+ V IGVTAGASAP LV QVI+ LR + + V E Sbjct 237 QRVGKPAYLIDSADDIKSEWIKGVDAIGVTAGASAPDILVQQVIERLRAFGADIVTELHG 296 Query 314 ATETVRFGLPKQVRAQ 329 E + F +PK++R + Sbjct 297 REENIVFEVPKELRVE 312 >gi|333898943|ref|YP_004472816.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas fulva 12-X] gi|333114208|gb|AEF20722.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas fulva 12-X] Length=314 Score = 332 bits (852), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 169/316 (54%), Positives = 218/316 (69%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR+RGAVFVE+L Sbjct 1 MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRNRGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A RGL+V DATCPLV KVH E R++ G Sbjct 61 DQVPDD----VIVIFSAHGVSQAVRNEAANRGLKVFDATCPLVTKVHLEVVRYSRDGREC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G S LV+ DVA L + + L+++TQTTL++D+T+ Sbjct 117 ILIGHEGHPEVEGTMGQYDVSNGGAIYLVEDEDDVATLQVRDPENLAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALRARFP++G P +DICYAT NRQ A++ + ECDV+LV+GS NSSNS RL ELA Sbjct 177 KVIDALRARFPSIGGPRKDDICYATQNRQDAVKQLAAECDVLLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPAYLIDG +D++ EW IG+TAGASAP LV VID L + + V E Sbjct 237 ERMGTPAYLIDGAEDLKREWFDGAKGIGITAGASAPEVLVRGVIDKLGEWGASNVQELDG 296 Query 314 ATETVRFGLPKQVRAQ 329 E V F +PK++R + Sbjct 297 RPENVTFSMPKELRLK 312 >gi|339066431|ref|ZP_08649437.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [gamma proteobacterium IMCC2047] gi|330719542|gb|EGG98140.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [gamma proteobacterium IMCC2047] Length=318 Score = 332 bits (852), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 171/316 (55%), Positives = 219/316 (70%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 +T+ LA+PR FCAGV+RAIE V R L++ PVYVR ++VHN VV +LR+RGAVFVE+L Sbjct 4 MTIKLANPRGFCAGVDRAIEIVNRALNIFGAPVYVRHEVVHNRYVVDDLRNRGAVFVEEL 63 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 DE+PD A+V+FSAHGVS AV+ A +RGL+V DATCPLV KVH E +F+ G Sbjct 64 DEVPD----DALVIFSAHGVSQAVQQEAQKRGLKVFDATCPLVTKVHMEVTKFSRAGQEC 119 Query 138 VFIGHAGHEETEGTLGVAPRS----TLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G S LVQ A VA L + L+++TQTTL++D+TA Sbjct 120 ILIGHAGHPEVEGTMGQYDNSAGGEMYLVQDVAGVAELPVKNAEHLAFVTQTTLSVDDTA 179 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 D+IDALRARFP + P +DICYAT NRQ A++ + E DVVLV+G+ NSSNS RL EL+ Sbjct 180 DIIDALRARFPKIEGPRKDDICYATQNRQDAVKVLADESDVVLVVGAANSSNSNRLRELS 239 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 R GTPAYLI+ +IEP W S IGVTAGASAP LV QVI+ L+ ++ E + Sbjct 240 DRLGTPAYLINDATEIEPRWFDGASQIGVTAGASAPQILVDQVIERLQALGAMAPEELAG 299 Query 314 ATETVRFGLPKQVRAQ 329 E + F LPK++R + Sbjct 300 REENITFSLPKELRLK 315 >gi|329895219|ref|ZP_08270883.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [gamma proteobacterium IMCC3088] gi|328922457|gb|EGG29799.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [gamma proteobacterium IMCC3088] Length=317 Score = 332 bits (852), Expect = 4e-89, Method: Compositional matrix adjust. Identities = 167/314 (54%), Positives = 220/314 (71%), Gaps = 8/314 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + V+LA+PR FCAGV+RAI+ V R LD+ P++VR ++VHN VVV +LR +GAVFVE+L Sbjct 1 MKVVLANPRGFCAGVDRAIDIVNRALDLLGAPIFVRHEVVHNKVVVDDLRSKGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 DE+P+ GA V+FSAHGVS AVR+ A+ RGL+V DATCPLV KVH E + GD Sbjct 61 DEVPE----GATVIFSAHGVSQAVRSEAERRGLKVFDATCPLVTKVHMEVTLHSRDGDEC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E +GT+G S LV+ DVA L + +LSY+TQTTL++D+TA Sbjct 117 ILIGHKGHPEVDGTMGQYDASNGGAMYLVEDEDDVAKLQVKNAERLSYVTQTTLSVDDTA 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALRARFP++ P +DICYAT NRQ A++++ + D +LV+GS NSSNS RL ELA Sbjct 177 RVIDALRARFPSIKGPRKDDICYATQNRQDAVKALAEQADCILVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 R GTPAYLIDGP+D++ +W + T+G+TAGASAP LV V A++ + VE Sbjct 237 VRMGTPAYLIDGPEDLQRDWFETCQTVGITAGASAPEHLVQAVAAAMQEWGGERAVELDG 296 Query 314 ATETVRFGLPKQVR 327 ET+ F LPK++R Sbjct 297 RRETITFSLPKELR 310 >gi|251788191|ref|YP_003002912.1| hydroxymethylbutenyl pyrophosphate reductase [Dickeya zeae Ech1591] gi|247536812|gb|ACT05433.1| hydroxymethylbutenyl pyrophosphate reductase [Dickeya zeae Ech1591] Length=316 Score = 332 bits (851), Expect = 5e-89, Method: Compositional matrix adjust. Identities = 166/313 (54%), Positives = 218/313 (70%), Gaps = 7/313 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L+V P+YVR ++VHN VV LR+RGAVF+E + Sbjct 1 MKILLANPRGFCAGVDRAISIVERALEVYGAPIYVRHEVVHNRYVVEGLRERGAVFIEQI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 +++PD GA+++FSAHGVS AVRA A R L + DATCPLV KVH E AR + +G Sbjct 61 EDVPD----GAILIFSAHGVSQAVRAEAKSRELTIFDATCPLVTKVHMEVARASRKGTEA 116 Query 138 VFIGHAGHEETEGTLGVAPR---STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 + IGHAGH E EGT+G LV+ P DV +L + + T L ++TQTTL++D+T+ Sbjct 117 ILIGHAGHPEVEGTMGQYNNPDGGMYLVEGPEDVWSLQVKDETNLCFMTQTTLSVDDTSA 176 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 VIDALRARFP + P +DICYATTNRQ A++++ E +VVLV+GS NSSNS RL ELAQ Sbjct 177 VIDALRARFPQIIGPRKDDICYATTNRQEAVRNLAAEANVVLVVGSKNSSNSNRLAELAQ 236 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 R G P+YLID DDI+ +WL V+ +GVTAGASAP LV QVI L+ +E Sbjct 237 RVGKPSYLIDSADDIQEQWLKDVACVGVTAGASAPDVLVQQVIKRLQAMGGKVAMEMQGR 296 Query 315 TETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 EENIVFEVPKELR 309 >gi|338997877|ref|ZP_08636561.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Halomonas sp. TD01] gi|338765240|gb|EGP20188.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Halomonas sp. TD01] Length=329 Score = 332 bits (850), Expect = 6e-89, Method: Compositional matrix adjust. Identities = 170/316 (54%), Positives = 218/316 (69%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 V + LA+PR FCAGV+RAI+ V R LDV P+YVR ++VHN VV LR+RGAVFVE+L Sbjct 13 VQIKLANPRGFCAGVDRAIDIVNRALDVFGPPIYVRHEVVHNRFVVETLRERGAVFVEEL 72 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 E+PD +V+FSAHGVS AV+ A++RGL+V DATCPLV KVH E R+A RG Sbjct 73 HEVPD----DVIVIFSAHGVSRAVQQEAEQRGLKVFDATCPLVTKVHLEVLRYAKRGQEC 128 Query 138 VFIGHAGHEETEGTLGVAPRS----TLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G S LV+ DVA L + + + L+++TQTTL++D+TA Sbjct 129 ILIGHEGHPEVEGTMGRYDTSHGGQIYLVEDEQDVAKLGVNDPSALAFVTQTTLSMDDTA 188 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALR +FP + P +DICYAT NRQ A++ + + D+VLV+GS NSSNS RL EL+ Sbjct 189 KVIDALREKFPEIQGPRKDDICYATQNRQDAVRELAADSDLVLVVGSPNSSNSNRLRELS 248 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPAYLID D IEP WL VS IGVTAGASAP LV VID L+ + + VE Sbjct 249 ERMGTPAYLIDNADQIEPAWLEGVSRIGVTAGASAPEVLVKGVIDKLQAFGAEVPVELQG 308 Query 314 ATETVRFGLPKQVRAQ 329 E + F +P+++R Q Sbjct 309 REENITFSMPRELREQ 324 >gi|253988040|ref|YP_003039396.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949] gi|253779490|emb|CAQ82651.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Photorhabdus asymbiotica] Length=317 Score = 332 bits (850), Expect = 7e-89, Method: Compositional matrix adjust. Identities = 165/316 (53%), Positives = 222/316 (71%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L++ P+YVR ++VHN VV LR+RGA+F+E++ Sbjct 1 MQILLANPRGFCAGVDRAISIVERALELYGAPIYVRHEVVHNRYVVDNLRERGAIFIEEI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVV-DATCPLVAKVHAEAARFAARGDT 136 E+PD A+++FSAHGVS A+RA A R L ++ DATCPLV KVH E AR + +G Sbjct 61 SEVPDD----AILIFSAHGVSQAIRAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKE 116 Query 137 VVFIGHAGHEETEGTLGV---APRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G A LV++P DV L + + L ++TQTTL++D+T+ Sbjct 117 AILIGHAGHPEVEGTMGQYNNAEGGMYLVESPEDVWNLKVKDEDNLCFMTQTTLSVDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 +VIDAL ARFP + P +DICYATTNRQ A++ + + DVVLV+GS NSSNS RL ELA Sbjct 177 EVIDALNARFPNIVGPRKDDICYATTNRQEAVRDLSSDADVVLVVGSKNSSNSNRLAELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 QR G PAYLID DDI+ EW++ +S +GVTAGASAP LV QVID L+ + +V E Sbjct 237 QRVGKPAYLIDSADDIKEEWITGISAVGVTAGASAPDILVQQVIDRLKNLGADSVKELHG 296 Query 314 ATETVRFGLPKQVRAQ 329 E + F +PK++R + Sbjct 297 REENIVFEVPKELRVE 312 >gi|271502095|ref|YP_003335121.1| hydroxymethylbutenyl pyrophosphate reductase [Dickeya dadantii Ech586] gi|270345650|gb|ACZ78415.1| hydroxymethylbutenyl pyrophosphate reductase [Dickeya dadantii Ech586] Length=316 Score = 331 bits (849), Expect = 8e-89, Method: Compositional matrix adjust. Identities = 167/313 (54%), Positives = 218/313 (70%), Gaps = 7/313 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L+V P+YVR ++VHN VV LRDRGAVF+E + Sbjct 1 MKILLANPRGFCAGVDRAISIVERALEVYGAPIYVRHEVVHNRYVVDGLRDRGAVFIEQI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 +++PD GA+++FSAHGVS AVRA A R L V DATCPLV KVH E AR + +G Sbjct 61 EDVPD----GAILIFSAHGVSQAVRAEAKSRELTVFDATCPLVTKVHMEVARASRKGTEA 116 Query 138 VFIGHAGHEETEGTLGVAPR---STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 + IGHAGH E EGT+G LV+ P DV +L + + T L ++TQTTL++D+T+ Sbjct 117 ILIGHAGHPEVEGTMGQYNNPAGGMYLVEGPEDVWSLQVKDETNLCFMTQTTLSVDDTSA 176 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 VIDALRARFP + P +DICYATTNRQ A++++ + +VVLV+GS NSSNS RL EL+Q Sbjct 177 VIDALRARFPQIIGPRKDDICYATTNRQEAVRNLAAQANVVLVVGSKNSSNSNRLAELSQ 236 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 R G P+YLID DDI+ EWL V+ +GVTAGASAP LV QVI L+ +E Sbjct 237 RVGKPSYLIDSADDIQEEWLKGVACVGVTAGASAPDVLVQQVIKRLQSMGGEVAMEMEGR 296 Query 315 TETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 AENIVFEVPKELR 309 >gi|299138493|ref|ZP_07031672.1| hydroxymethylbutenyl pyrophosphate reductase [Acidobacterium sp. MP5ACTX8] gi|298599739|gb|EFI55898.1| hydroxymethylbutenyl pyrophosphate reductase [Acidobacterium sp. MP5ACTX8] Length=341 Score = 331 bits (849), Expect = 8e-89, Method: Compositional matrix adjust. Identities = 167/307 (55%), Positives = 220/307 (72%), Gaps = 4/307 (1%) Query 20 VLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDE 79 VLL PR FCAGV RA++ VK LD P+YVRK+IVHN+ VV +L +GA+FV +LDE Sbjct 23 VLLLKPRGFCAGVVRAVDIVKIALDTFGAPIYVRKEIVHNSYVVNDLAGKGAIFVNELDE 82 Query 80 IPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVF 139 +P GA V++SAHGVSPAVR A ERGL+V+DATCPLV KVH EA +FA +G ++V Sbjct 83 VP----AGARVIYSAHGVSPAVREHAKERGLKVIDATCPLVTKVHVEAIKFAKQGYSLVL 138 Query 140 IGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDAL 199 +GH HEE EGT G AP T +V T +VAAL +P+ +++YLTQTTL+LDE +I+AL Sbjct 139 VGHRDHEEVEGTQGEAPTVTQVVSTVEEVAALVVPDPNKVAYLTQTTLSLDEARYMIEAL 198 Query 200 RARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTP 259 + +FP + P ++DICYAT NRQ A++++ DVVLV+GS NSSNS RLVE++Q GT Sbjct 199 KKKFPNIVGPHAQDICYATENRQTAVKNVAHGADVVLVVGSRNSSNSNRLVEVSQNLGTN 258 Query 260 AYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVR 319 +YLID +DI EW+ +VST+ +TAGASAP LV V+ L+G +V E + E VR Sbjct 259 SYLIDKAEDIRAEWIENVSTVAITAGASAPEILVQDVVQYLQGKGYGSVEEVEVMPENVR 318 Query 320 FGLPKQV 326 FGLP ++ Sbjct 319 FGLPPEI 325 >gi|146305991|ref|YP_001186456.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas mendocina ymp] gi|166217478|sp|A4XQV8.1|ISPH_PSEMY RecName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase gi|145574192|gb|ABP83724.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas mendocina ymp] Length=314 Score = 331 bits (849), Expect = 8e-89, Method: Compositional matrix adjust. Identities = 166/316 (53%), Positives = 217/316 (69%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR RGAVFVE+L Sbjct 1 MHIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRARGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A RGL+V DATCPLV KVH E R++ G Sbjct 61 DQVPDD----VIVIFSAHGVSKAVRDEAARRGLKVFDATCPLVTKVHMEVVRYSREGREC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G S LV+ ADVA L + L+++TQTTL++D+T+ Sbjct 117 ILIGHEGHPEVEGTMGQYDASNGGAIYLVEDEADVAELQVRNPDNLAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALR++FP +G P +DICYAT NRQ A++ + ECDV+LV+GS NSSNS RL ELA Sbjct 177 KVIDALRSKFPAIGGPRKDDICYATQNRQDAVKQLASECDVLLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPAYLIDG +D++ EW V IG+TAGASAP LV V++ LR + + E Sbjct 237 ERMGTPAYLIDGAEDLKHEWFEGVKGIGITAGASAPEVLVRGVVEQLRAWGAAGETELDG 296 Query 314 ATETVRFGLPKQVRAQ 329 E + F +PK++R + Sbjct 297 RPENITFSMPKELRVK 312 >gi|320540427|ref|ZP_08040077.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein [Serratia symbiotica str. Tucson] gi|320029358|gb|EFW11387.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein [Serratia symbiotica str. Tucson] Length=317 Score = 331 bits (848), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 170/314 (55%), Positives = 219/314 (70%), Gaps = 8/314 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L++ P+YVR ++VHN VV LR+RGAVF+E++ Sbjct 1 MQILLANPRGFCAGVDRAISIVERALELYGAPIYVRHEVVHNRYVVHSLRERGAVFIEEI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVV-DATCPLVAKVHAEAARFAARGDT 136 E+PD G+++VFSAHGVS AVRA A R L ++ DATCPLV KVH E AR + RG Sbjct 61 SEVPD----GSILVFSAHGVSQAVRAEAKARDLTMLFDATCPLVTKVHMEVARASRRGTE 116 Query 137 VVFIGHAGHEETEGTLGVAPR---STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G LV++P DV L + + L ++TQTTL++D+T+ Sbjct 117 AILIGHAGHPEVEGTMGQYSNLEGGMYLVESPKDVWQLQVKDENNLCFMTQTTLSVDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 DVIDALR RFP++ P +DICYATTNRQ A++++ + DVVLV+GS NSSNS RL ELA Sbjct 177 DVIDALRQRFPSIIGPRKDDICYATTNRQEAVRNLADDADVVLVVGSKNSSNSNRLAELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 QR G PAYLID DI+ WLS VS IGVTAGASAP LV +VI L+ V E S Sbjct 237 QRVGKPAYLIDSASDIQEAWLSQVSNIGVTAGASAPDVLVQEVISRLKALGGKEVHEISG 296 Query 314 ATETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 REENIVFEVPKELR 310 >gi|104783643|ref|YP_610141.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas entomophila L48] gi|122401810|sp|Q1I4S8.1|ISPH_PSEE4 RecName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase gi|95112630|emb|CAK17358.1| hydroxymethylbutenyl pyrophosphate reductase [Pseudomonas entomophila L48] Length=315 Score = 331 bits (848), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 167/316 (53%), Positives = 216/316 (69%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR+RGAVFVE+L Sbjct 1 MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRNRGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A RGL+V DATCPLV KVH E A+++ G Sbjct 61 DQVPDD----VIVIFSAHGVSQAVRQEAAGRGLKVFDATCPLVTKVHIEVAKYSRDGREC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G S LV+ DVAAL + L+++TQTTL++D+T+ Sbjct 117 ILIGHAGHPEVEGTMGQYDASNGGSIYLVEDEKDVAALQVRNPDHLAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALR RFP +G P +DICYAT NRQ A++ + ECDVVLV+GS NSSNS RL ELA Sbjct 177 RVIDALRERFPNIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R TPAYLIDG +D++ W IG+TAGASAP LV VID L+ + + E Sbjct 237 ERMSTPAYLIDGAEDLQRSWFDGAQRIGITAGASAPEVLVRGVIDQLKAWGATGAEELDG 296 Query 314 ATETVRFGLPKQVRAQ 329 E + F +PK++R + Sbjct 297 REENITFSMPKELRVR 312 >gi|330501958|ref|YP_004378827.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas mendocina NK-01] gi|328916244|gb|AEB57075.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas mendocina NK-01] Length=314 Score = 330 bits (846), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 166/314 (53%), Positives = 216/314 (69%), Gaps = 8/314 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR RGAVFVE+L Sbjct 1 MYIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRARGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A RGL+V DATCPLV KVH E R++ G Sbjct 61 DQVPDD----VIVIFSAHGVSKAVRDEAARRGLKVFDATCPLVTKVHMEVVRYSREGREC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G S LV+ ADVA L + L+++TQTTL++D+T+ Sbjct 117 ILIGHEGHPEVEGTMGQYDASNGGAIYLVEDEADVAELQVRNPENLAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALRA+FP +G P +DICYAT NRQ A++ + +CDV+LV+GS NSSNS RL ELA Sbjct 177 KVIDALRAKFPAIGGPRKDDICYATQNRQDAVKQLASDCDVLLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPAYLIDG +D++ EW V +G+TAGASAP LV V+D LR + + E Sbjct 237 ERMGTPAYLIDGAEDLKAEWFEGVDGVGITAGASAPEVLVRGVVDQLRAWGAEGETELDG 296 Query 314 ATETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 RPENITFSMPKELR 310 >gi|327479532|gb|AEA82842.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas stutzeri DSM 4166] Length=314 Score = 330 bits (846), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 165/316 (53%), Positives = 221/316 (70%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR RGAVFVE+L Sbjct 1 MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRARGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A++RGL+V DATCPLV KVH E A+++ G Sbjct 61 DQVPD----NVIVIFSAHGVSQAVRQEAEKRGLKVFDATCPLVTKVHLEVAKYSREGREC 116 Query 138 VFIGHAGHEETEGTLGVAPR----STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G + LV+ DVA L + L+++TQTTL++D+T+ Sbjct 117 ILIGHQGHPEVEGTMGQYDARNGGTIYLVEDEEDVAQLQVRNPEALAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALR+++P++G P +DICYAT NRQ A++ + ECDVVLV+GS NSSNS RL ELA Sbjct 177 RVIDALRSKYPSIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R TPAYLIDG +D++ EW SV IG+TAGASAP LV VI+ L+ + + + E Sbjct 237 ERMNTPAYLIDGAEDLKREWFESVERIGITAGASAPEVLVRGVIERLKEWGASGMAELEG 296 Query 314 ATETVRFGLPKQVRAQ 329 E V F +PK++R + Sbjct 297 RPENVTFSMPKELRVK 312 >gi|157368946|ref|YP_001476935.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Serratia proteamaculans 568] gi|166973801|sp|A8G9L7.1|ISPH_SERP5 RecName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase gi|157320710|gb|ABV39807.1| hydroxymethylbutenyl pyrophosphate reductase [Serratia proteamaculans 568] Length=317 Score = 330 bits (846), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 168/314 (54%), Positives = 221/314 (71%), Gaps = 8/314 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L++ P+YVR ++VHN VV LR+RGAVF+E++ Sbjct 1 MQILLANPRGFCAGVDRAISIVERALEIYGAPIYVRHEVVHNRYVVDSLRERGAVFIEEI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVV-DATCPLVAKVHAEAARFAARGDT 136 E+PD G++++FSAHGVS AVRA A R L ++ DATCPLV KVH E AR + RG Sbjct 61 TEVPD----GSILIFSAHGVSQAVRAEAKARDLTMLFDATCPLVTKVHMEVARASRRGTE 116 Query 137 VVFIGHAGHEETEGTLG--VAPRSTL-LVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G P+ + LV++P DV L + + + L ++TQTTL++D+T+ Sbjct 117 AILIGHAGHPEVEGTMGQYSNPKGGMYLVESPDDVWKLQVKDESNLCFMTQTTLSVDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 DVIDALR RFP++ P +DICYATTNRQ A++++ G+ DVVLV+GS NSSNS RL ELA Sbjct 177 DVIDALRKRFPSIIGPRKDDICYATTNRQEAVRNLAGDADVVLVVGSKNSSNSNRLAELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 QR G PAYLID DI+ WL IGVTAGASAP LV VI L+ + V E S Sbjct 237 QRVGKPAYLIDSAADIQEAWLKDAHNIGVTAGASAPDVLVQDVISRLKALGGVNVQEVSG 296 Query 314 ATETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 REENIVFEVPKELR 310 >gi|307132644|ref|YP_003884660.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase 4Fe-4S protein [Dickeya dadantii 3937] gi|306530173|gb|ADN00104.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein [Dickeya dadantii 3937] Length=316 Score = 330 bits (846), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 167/313 (54%), Positives = 217/313 (70%), Gaps = 7/313 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L+V P+YVR ++VHN VV LR+RGA+F+E + Sbjct 1 MKILLANPRGFCAGVDRAISIVERALEVYGAPIYVRHEVVHNRYVVEGLRERGAIFIEQI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 +++PD GA+++FSAHGVS AVRA A R L V DATCPLV KVH E AR + +G Sbjct 61 EDVPD----GAILIFSAHGVSQAVRAEAKSRELTVFDATCPLVTKVHMEVARASRKGTEA 116 Query 138 VFIGHAGHEETEGTLGVAPR---STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 + IGHAGH E EGT+G LV+ P DV AL + + + L ++TQTTL++D+T+ Sbjct 117 ILIGHAGHPEVEGTMGQYNNPNGGMYLVEGPEDVWALQVKDESNLCFMTQTTLSVDDTSA 176 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 VIDALRARFP + P +DICYATTNRQ A++++ E VVLV+GS NSSNS RL ELAQ Sbjct 177 VIDALRARFPQIVGPRKDDICYATTNRQEAVRNLAAEASVVLVVGSKNSSNSNRLAELAQ 236 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 R G P+YLID DDI+ WL SV+ +GVTAGASAP LV QVI L+ +E Sbjct 237 RVGKPSYLIDSADDIQEGWLKSVACVGVTAGASAPDVLVQQVIKRLQSMGGQIAMEMQGR 296 Query 315 TETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 EENIVFEVPKELR 309 >gi|192360516|ref|YP_001983668.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Cellvibrio japonicus Ueda107] gi|190686681|gb|ACE84359.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Cellvibrio japonicus Ueda107] Length=314 Score = 330 bits (845), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 167/313 (54%), Positives = 217/313 (70%), Gaps = 8/313 (2%) Query 20 VLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDE 79 + LA+PR FCAGV+RAI+ V R LDV P+YVR ++VHN VV LR+RGAVFV+++D+ Sbjct 4 IKLANPRGFCAGVDRAIDIVNRALDVFGAPIYVRHEVVHNKFVVESLRERGAVFVDEVDQ 63 Query 80 IPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVF 139 +PD +++FSAHGVS AVR A+ RGL+V DATCPLV KVH E R++ G + Sbjct 64 VPD----NVILIFSAHGVSQAVRKEAESRGLKVFDATCPLVTKVHIEVTRYSREGKECIL 119 Query 140 IGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETADV 195 IGH GH E EGT+G S LV+ ADV AL + L+Y+TQTTL++D+TA V Sbjct 120 IGHEGHPEVEGTMGQYDASNGGTIYLVEDEADVDALQVRNPEALAYVTQTTLSMDDTARV 179 Query 196 IDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQR 255 I+ALR +FP + P +DICYATTNRQ A++ + ECD+VLV+GS NSSNS RL ELA+R Sbjct 180 IEALRNKFPKIQGPRKDDICYATTNRQDAVRQLALECDLVLVVGSPNSSNSNRLRELAER 239 Query 256 SGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIAT 315 GT AYLIDGP+DI PEW++ + IG+TAGASAP LV QVI L+ + E Sbjct 240 CGTEAYLIDGPEDISPEWIAGRTAIGITAGASAPEVLVQQVITRLQACGAEMPREMDGTP 299 Query 316 ETVRFGLPKQVRA 328 E + F LPK++R+ Sbjct 300 ENISFSLPKELRS 312 >gi|343919306|gb|EGV30056.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Thiorhodococcus drewsii AZ1] Length=315 Score = 330 bits (845), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 166/312 (54%), Positives = 218/312 (70%), Gaps = 7/312 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+RVLD+ P+YVR ++VHN VV LR RGA+F+EDL Sbjct 1 MNILLANPRGFCAGVDRAIAIVERVLDLYGSPIYVRHEVVHNRFVVEGLRQRGAIFIEDL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 DE+PD GA +VFSAHGV AVR A R L++ DATCPLV KVH E AR+ G +V Sbjct 61 DEVPD----GATLVFSAHGVPQAVRQAAQARELKLFDATCPLVTKVHLEVARYCQNGISV 116 Query 138 VFIGHAGHEETEGTLGVAPRST---LLVQTPADVAALNLPEGTQLSYLTQTTLALDETAD 194 + IGH GH E EGTLG + LV+ D+A L +P+ +++Y+TQTTL++D++ D Sbjct 117 ILIGHRGHPEVEGTLGQCTGDSGTIQLVEGVKDIADLKIPDPERVAYVTQTTLSMDDSRD 176 Query 195 VIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQ 254 +IDALRARFP + P DICYAT NRQ A++ + CD++LV+GS NSSNS RL ELA+ Sbjct 177 IIDALRARFPAIQGPKKSDICYATQNRQDAVRDLAKRCDLLLVVGSPNSSNSNRLRELAE 236 Query 255 RSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIA 314 + G AYLIDGP+DI EWL++ S IGVTAGASAP LV +V LR + + + E+ Sbjct 237 KQGCSAYLIDGPEDISREWLNASSRIGVTAGASAPAILVERVTGCLRDWGATEIEEQDGI 296 Query 315 TETVRFGLPKQV 326 E V F LP+++ Sbjct 297 REQVVFALPREL 308 >gi|88800789|ref|ZP_01116346.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Reinekea sp. MED297] gi|88776495|gb|EAR07713.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Reinekea sp. MED297] Length=315 Score = 330 bits (845), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 168/314 (54%), Positives = 216/314 (69%), Gaps = 8/314 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAI+ V R L+V P+YVR ++VHN VV +L+ RGA+FV++L Sbjct 1 MDIKLANPRGFCAGVDRAIDIVNRALEVHGAPLYVRHEVVHNKFVVEDLKSRGAIFVDEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 DE+PD V+FSAHGVS AVR AD RGL+V DATCPLV KVH E AR++ G Sbjct 61 DEVPD----DNWVIFSAHGVSQAVRKEADRRGLRVYDATCPLVTKVHLEVARYSREGMEC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G RS LV+ A V AL + +L+Y+TQTTL++D+TA Sbjct 117 ILIGHRGHPEVEGTMGQYDRSNGGEIYLVEAEACVDALQVKHPDRLAYVTQTTLSMDDTA 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 +IDALRA+FP + P +DICYAT NRQ A++++ +CDVV+V+GS NSSNS RL ELA Sbjct 177 RIIDALRAKFPQIQGPRKDDICYATQNRQDAVKTLARDCDVVIVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R G AYLID D +EP W S IGVTAGASAP LV QVID L+ Y + VE Sbjct 237 ERIGCDAYLIDSVDQLEPAWFEGKSQIGVTAGASAPDILVKQVIDGLQNYGANPPVELDG 296 Query 314 ATETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 VQENITFSMPKELR 310 >gi|339492946|ref|YP_004713239.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas stutzeri ATCC 17588 = LMG 11199] gi|338800318|gb|AEJ04150.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas stutzeri ATCC 17588 = LMG 11199] Length=314 Score = 330 bits (845), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 164/316 (52%), Positives = 220/316 (70%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR RGAVFVE+L Sbjct 1 MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRARGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A++RGL+V DATCPLV KVH E A+++ G Sbjct 61 DQVPD----NVIVIFSAHGVSQAVRQEAEKRGLKVFDATCPLVTKVHLEVAKYSREGREC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G LV+ DVA L + L+++TQTTL++D+T+ Sbjct 117 ILIGHQGHPEVEGTMGQYDSRNGGAIYLVEDEEDVAQLQVRNPETLAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALR+++P++G P +DICYAT NRQ A++ + ECDVVLV+GS NSSNS RL ELA Sbjct 177 RVIDALRSKYPSIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R TPAYLIDG +D++ EW SV IG+TAGASAP LV V++ L+ + + + E Sbjct 237 ERMNTPAYLIDGAEDLKREWFESVERIGITAGASAPEVLVRGVMERLKEWGASDMAELEG 296 Query 314 ATETVRFGLPKQVRAQ 329 E V F +PK++R + Sbjct 297 RPENVTFSMPKELRVK 312 >gi|170723717|ref|YP_001751405.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas putida W619] gi|229486013|sp|B1JF80.1|ISPH_PSEPW RecName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase gi|169761720|gb|ACA75036.1| hydroxymethylbutenyl pyrophosphate reductase [Pseudomonas putida W619] Length=315 Score = 330 bits (845), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 166/316 (53%), Positives = 217/316 (69%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR RGA+FVE+L Sbjct 1 MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRSRGAIFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A RGL+V DATCPLV KVH E A+++ G Sbjct 61 DQVPDD----VIVIFSAHGVSQAVRQEAAGRGLKVFDATCPLVTKVHIEVAKYSRDGREC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGH GH E EGT+G S LV+ DVA L + + L+++TQTTL++D+T+ Sbjct 117 ILIGHEGHPEVEGTMGQYDASNGGAIYLVEDEEDVARLQVRDPDNLAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALR RFP +G P +DICYAT NRQ A++ + GECDVVLV+GS NSSNS RL ELA Sbjct 177 RVIDALRTRFPNIGGPRKDDICYATQNRQDAVKQLAGECDVVLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPAYLIDG +D++ W + IG+TAGASAP LV VID L+ + + E Sbjct 237 ERMGTPAYLIDGAEDMQRGWFDQAARIGITAGASAPEVLVRGVIDQLKAWGATGAEELDG 296 Query 314 ATETVRFGLPKQVRAQ 329 E + F +PK++R + Sbjct 297 RPENITFSMPKELRVR 312 >gi|152984227|ref|YP_001350529.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas aeruginosa PA7] gi|150959385|gb|ABR81410.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas aeruginosa PA7] Length=314 Score = 329 bits (844), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 169/316 (54%), Positives = 214/316 (68%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R LDV P+YVR ++VHN VV LR RGAVFVE+L Sbjct 1 MQIKLANPRGFCAGVDRAIEIVNRALDVFGPPIYVRHEVVHNKFVVDNLRQRGAVFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A+ RGL+V DATCPLV KVH E R++ G Sbjct 61 DQVPD----NVIVIFSAHGVSQAVRKEAEGRGLKVFDATCPLVTKVHMEVVRYSRDGHEC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 V IGH GH E EGT+G S LV+ ADVAAL + + L Y+TQTTL++D+T+ Sbjct 117 VLIGHEGHPEVEGTMGQYDTSNGGAIYLVEDEADVAALEVRKPEALHYVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALRA+FP + P DICYAT NRQ A++ + +CD+VLV+GS NSSNS RL ELA Sbjct 177 KVIDALRAKFPQIQGPRKNDICYATQNRQDAVKELADQCDMVLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GTPAYLIDG +D++ W V IG+TAGASAP LV VI LR + + E Sbjct 237 ERMGTPAYLIDGAEDMQRGWFDGVRRIGITAGASAPEVLVRGVIAQLREWGASEEQELDG 296 Query 314 ATETVRFGLPKQVRAQ 329 E + F +PK++R + Sbjct 297 REENITFSMPKELRVK 312 >gi|90022208|ref|YP_528035.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Saccharophagus degradans 2-40] gi|123090297|sp|Q21HK6.1|ISPH_SACD2 RecName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase gi|89951808|gb|ABD81823.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Saccharophagus degradans 2-40] Length=311 Score = 329 bits (844), Expect = 4e-88, Method: Compositional matrix adjust. Identities = 164/314 (53%), Positives = 218/314 (70%), Gaps = 8/314 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAI+ V R LDV P+YVR ++VHN VV L++RGA+FV++L Sbjct 1 MEIKLANPRGFCAGVDRAIDIVNRALDVFGAPIYVRHEVVHNKFVVERLKERGAIFVDEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 + +PD +V+FSAHGVS AVR AD RGL+V DATCPLV KVH E A+++ G Sbjct 61 EAVPDD----VIVIFSAHGVSQAVRQEADRRGLKVFDATCPLVTKVHMEVAKYSNDGCEC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 V IGH GH E EGT+G + LV+ +DV L + + T+LSY+TQTTL++D+TA Sbjct 117 VLIGHEGHPEVEGTMGQYDTANGGAIYLVEDESDVEQLEVRDPTRLSYVTQTTLSMDDTA 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VID+LRA+FP + P +DICYAT NRQ A++ + ECD+VLV+GS NSSNS RL ELA Sbjct 177 RVIDSLRAKFPHITGPRKDDICYATQNRQDAVKQLALECDLVLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R GT AYLIDGP+D++ W ++ IG+TAGASAP LV VI+ L+ + VE Sbjct 237 ERCGTAAYLIDGPEDLDKSWFANCKNIGITAGASAPEVLVRDVIEGLKAIGASAPVELQG 296 Query 314 ATETVRFGLPKQVR 327 E + F LPK++R Sbjct 297 QEENISFSLPKELR 310 >gi|300724590|ref|YP_003713915.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein [Xenorhabdus nematophila ATCC 19061] gi|297631132|emb|CBJ91821.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein [Xenorhabdus nematophila ATCC 19061] Length=317 Score = 329 bits (844), Expect = 4e-88, Method: Compositional matrix adjust. Identities = 167/314 (54%), Positives = 219/314 (70%), Gaps = 8/314 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + +LLA+PR FCAGV+RAI V+R L++ P+YVR ++VHN VV LR RGA+F+E++ Sbjct 1 MQILLANPRGFCAGVDRAISIVERALELYGAPIYVRHEVVHNRYVVDNLRKRGAIFIEEI 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVV-DATCPLVAKVHAEAARFAARGDT 136 E+PD GA+++FSAHGVS A+RA A R L ++ DATCPLV KVH E AR + +G Sbjct 61 SEVPD----GAILIFSAHGVSQAIRAEARSRDLTMLFDATCPLVTKVHMEVARASRKGKE 116 Query 137 VVFIGHAGHEETEGTLGVAPR---STLLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G LV++P DV L++ + L ++TQTTL++D+T+ Sbjct 117 AILIGHAGHPEVEGTMGQYNNPEGGMYLVESPEDVWKLHVKDENNLCFMTQTTLSVDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDAL ARFP + P +DICYATTNRQ A++ + DVVLV+GS NSSNS RL ELA Sbjct 177 AVIDALNARFPNIVGPRKDDICYATTNRQEAVRDLAVGADVVLVVGSKNSSNSNRLAELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 QR G PAYLID DDI+ EW+ VS IGVTAGASAP LV QVI+ L+ + + TV E Sbjct 237 QRVGKPAYLIDSADDIQAEWVKGVSAIGVTAGASAPDILVQQVIERLKTFGAKTVNELHG 296 Query 314 ATETVRFGLPKQVR 327 E + F +PK++R Sbjct 297 REENIVFEVPKELR 310 >gi|237801853|ref|ZP_04590314.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas syringae pv. oryzae str. 1_6] gi|237805331|ref|ZP_04592035.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas syringae pv. oryzae str. 1_6] gi|331024711|gb|EGI04767.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas syringae pv. oryzae str. 1_6] gi|331026438|gb|EGI06493.1| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Pseudomonas syringae pv. oryzae str. 1_6] Length=315 Score = 329 bits (843), Expect = 4e-88, Method: Compositional matrix adjust. Identities = 166/316 (53%), Positives = 217/316 (69%), Gaps = 8/316 (2%) Query 18 VTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDL 77 + + LA+PR FCAGV+RAIE V R L+V P+YVR ++VHN VV +LR RGA+FVE+L Sbjct 1 MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRSRGAIFVEEL 60 Query 78 DEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTV 137 D++PD +V+FSAHGVS AVR A RGL+V DATCPLV KVH E AR++ G Sbjct 61 DQVPDD----VIVIFSAHGVSQAVRTEASGRGLKVFDATCPLVTKVHIEVARYSRDGREC 116 Query 138 VFIGHAGHEETEGTLGVAPRST----LLVQTPADVAALNLPEGTQLSYLTQTTLALDETA 193 + IGHAGH E EGT+G + LV+ ADVA+L + L+++TQTTL++D+T+ Sbjct 117 ILIGHAGHPEVEGTMGQYDAANGGAIYLVEDEADVASLQVRNPESLAFVTQTTLSMDDTS 176 Query 194 DVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELA 253 VIDALR RFP +G P +DICYAT NRQ A++ + ECDVVLV+GS NSSNS RL ELA Sbjct 177 RVIDALRQRFPAIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELA 236 Query 254 QRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSI 313 +R TPAYLIDG +D++ W V IG+TAGASAP LV VI L+ + + E + Sbjct 237 ERMATPAYLIDGAEDMQQSWFEGVERIGITAGASAPEVLVRGVIQQLQAWGATGADELAG 296 Query 314 ATETVRFGLPKQVRAQ 329 E + F +PK++R + Sbjct 297 REENITFSMPKELRVK 312 Lambda K H 0.317 0.133 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 583580000052 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40