BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3397c Length=302 Score E Sequences producing significant alignments: (Bits) Value gi|15610533|ref|NP_217914.1| phytoene synthase [Mycobacterium tu... 600 8e-170 gi|302526349|ref|ZP_07278691.1| squalene synthase HpnD [Streptom... 297 2e-78 gi|111220883|ref|YP_711677.1| putative phytoene synthase [Franki... 277 1e-72 gi|336177209|ref|YP_004582584.1| squalene synthase HpnD [Frankia... 276 3e-72 gi|158317464|ref|YP_001509972.1| squalene/phytoene synthase [Fra... 276 3e-72 gi|86739533|ref|YP_479933.1| squalene/phytoene synthase [Frankia... 266 4e-69 gi|288922393|ref|ZP_06416583.1| squalene synthase HpnD [Frankia ... 260 1e-67 gi|331697461|ref|YP_004333700.1| squalene synthase HpnD [Pseudon... 259 3e-67 gi|312199713|ref|YP_004019774.1| squalene synthase HpnD [Frankia... 251 1e-64 gi|134100863|ref|YP_001106524.1| putative squalene/phytoene synt... 248 9e-64 gi|291003523|ref|ZP_06561496.1| probable phytoene synthase [Sacc... 248 1e-63 gi|117928901|ref|YP_873452.1| squalene/phytoene synthase [Acidot... 247 1e-63 gi|326775275|ref|ZP_08234540.1| squalene synthase HpnD [Streptom... 243 2e-62 gi|182434758|ref|YP_001822477.1| putative squalene/phytoene synt... 243 3e-62 gi|257056314|ref|YP_003134146.1| squalene synthase HpnD [Sacchar... 242 6e-62 gi|291449097|ref|ZP_06588487.1| squalene/phytoene synthase [Stre... 240 2e-61 gi|239992109|ref|ZP_04712773.1| putative squalene/phytoene synth... 240 2e-61 gi|328886495|emb|CCA59734.1| Phytoene synthase [Streptomyces ven... 240 2e-61 gi|320007259|gb|ADW02109.1| squalene synthase HpnD [Streptomyces... 239 4e-61 gi|256395790|ref|YP_003117354.1| squalene synthase HpnD [Catenul... 238 6e-61 gi|345003393|ref|YP_004806247.1| squalene synthase HpnD [Strepto... 236 3e-60 gi|311895178|dbj|BAJ27586.1| putative phytoene synthase [Kitasat... 235 8e-60 gi|297190553|ref|ZP_06907951.1| phytoene synthase [Streptomyces ... 233 2e-59 gi|219964680|gb|ACL68404.1| squalene/phytoene synthase [Streptom... 233 4e-59 gi|289767674|ref|ZP_06527052.1| squalene synthase HpnD [Streptom... 232 6e-59 gi|318058276|ref|ZP_07976999.1| probable phytoene synthase [Stre... 231 8e-59 gi|295835548|ref|ZP_06822481.1| squalene synthase HpnD [Streptom... 230 2e-58 gi|302522952|ref|ZP_07275294.1| squalene synthase HpnD [Streptom... 230 2e-58 gi|294816064|ref|ZP_06774707.1| Putative squalene/phytoene synth... 230 2e-58 gi|21225053|ref|NP_630832.1| phytoene synthase [Streptomyces coe... 230 2e-58 gi|333023209|ref|ZP_08451273.1| putative squalene/phytoene synth... 230 2e-58 gi|302541343|ref|ZP_07293685.1| squalene synthase HpnD [Streptom... 229 4e-58 gi|302537964|ref|ZP_07290306.1| squalene synthase HpnD [Streptom... 228 9e-58 gi|254385934|ref|ZP_05001252.1| squalene/phytoene synthase [Stre... 228 1e-57 gi|329937104|ref|ZP_08286733.1| squalene/phytoene synthase [Stre... 226 4e-57 gi|29828195|ref|NP_822829.1| squalene/phytoene synthase [Strepto... 225 6e-57 gi|297155998|gb|ADI05710.1| probable phytoene synthase [Streptom... 221 8e-56 gi|297203850|ref|ZP_06921247.1| squalene synthase HpnD [Streptom... 221 1e-55 gi|302557116|ref|ZP_07309458.1| squalene synthase HpnD [Streptom... 220 2e-55 gi|290955845|ref|YP_003487027.1| squalene/phytoene synthase [Str... 218 1e-54 gi|294632399|ref|ZP_06710959.1| squalene synthase HpnD [Streptom... 217 2e-54 gi|345010489|ref|YP_004812843.1| squalene synthase HpnD [Strepto... 215 6e-54 gi|302555530|ref|ZP_07307872.1| squalene synthase HpnD [Streptom... 214 1e-53 gi|291435807|ref|ZP_06575197.1| phytoene synthase [Streptomyces ... 209 3e-52 gi|337768915|emb|CCB77628.1| putative phytoene synthase [Strepto... 209 3e-52 gi|254447234|ref|ZP_05060701.1| phytoene synthase [gamma proteob... 167 2e-39 gi|220934696|ref|YP_002513595.1| terpenoid synthase [Thioalkaliv... 165 8e-39 gi|258592263|emb|CBE68572.1| Squalene/phytoene synthase [NC10 ba... 163 4e-38 gi|335042066|ref|ZP_08535093.1| phytoene/squalene synthetase [Me... 159 7e-37 gi|91775822|ref|YP_545578.1| squalene/phytoene synthase [Methylo... 154 2e-35 >gi|15610533|ref|NP_217914.1| phytoene synthase [Mycobacterium tuberculosis H37Rv] gi|15842991|ref|NP_338028.1| phytoene synthase-related protein [Mycobacterium tuberculosis CDC1551] gi|31794578|ref|NP_857071.1| phytoene synthase [Mycobacterium bovis AF2122/97] 80 more sequence titles Length=302 Score = 600 bits (1547), Expect = 8e-170, Method: Compositional matrix adjust. Identities = 302/302 (100%), Positives = 302/302 (100%), Gaps = 0/302 (0%) Query 1 MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETK 60 MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETK Sbjct 1 MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETK 60 Query 61 ITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 ITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE Sbjct 61 ITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPR 180 LIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPR Sbjct 121 LIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPR 180 Query 181 DELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAA 240 DELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAA Sbjct 181 DELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAA 240 Query 241 MSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASSVTCGPAHGPLPADLGSHP 300 MSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASSVTCGPAHGPLPADLGSHP Sbjct 241 MSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASSVTCGPAHGPLPADLGSHP 300 Query 301 SH 302 SH Sbjct 301 SH 302 >gi|302526349|ref|ZP_07278691.1| squalene synthase HpnD [Streptomyces sp. AA4] gi|302435244|gb|EFL07060.1| squalene synthase HpnD [Streptomyces sp. AA4] Length=303 Score = 297 bits (760), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 158/282 (57%), Positives = 201/282 (72%), Gaps = 4/282 (1%) Query 1 MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAP-ET 59 + +++AY ++T+ ARNFYYGIRLLP KRAAL AVYAL R IDD+ D A ET Sbjct 18 LGTVDEAYAHCAAVTKEQARNFYYGIRLLPPGKRAALCAVYALARIIDDIGDDTAASAET 77 Query 60 KITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFD 119 K+ L +RK+L ++ ++DPV VA+ADAARR+P+P+ F EL+DG M++ F+ Sbjct 78 KLQGLAGVRKALGDLSSTADPVYVAVADAARRYPIPLGAFEELLDGVEMDVTGREYVRFE 137 Query 120 ELIVYCRRGAGTIGKLCLSIFG--PVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIY 177 EL+ YCR AG++G+LCL +FG P A YA++LGIALQQTNILRD+RED LNGR+Y Sbjct 138 ELVEYCRCVAGSVGRLCLGVFGSRPEPNAPV-YADELGIALQQTNILRDIREDLLNGRVY 196 Query 178 LPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAAC 237 LP+++LDR GV L + G L DP+G LAAL+ SA RA DWY+ GLRL+P LD RSAAC Sbjct 197 LPKEDLDRFGVELSVGPDGKLADPEGGLAALIHDSATRARDWYARGLRLVPSLDGRSAAC 256 Query 238 CAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAAL 279 C AMSGIYR L I PA V+DRR+SLSG +KA VA AL Sbjct 257 CTAMSGIYRTLLDRIDEQPARVFDRRLSLSGREKAVVAFRAL 298 >gi|111220883|ref|YP_711677.1| putative phytoene synthase [Frankia alni ACN14a] gi|111148415|emb|CAJ60087.1| Putative phytoene synthase [Frankia alni ACN14a] Length=299 Score = 277 bits (709), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 151/283 (54%), Positives = 188/283 (67%), Gaps = 5/283 (1%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + +AY E++T+ AARNF YGIRLLP EKR ALSAVYAL R +DD+ DG+L PE K+ Sbjct 10 VAEAYAACEALTKEAARNFSYGIRLLPPEKRGALSAVYALARHLDDIGDGDLPPEEKLAG 69 Query 64 LDAIRKSLDNID-DSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELI 122 L +R ++N+ SSDP+ VAL DAARRFP+P+ F EL DG ++ T FD+++ Sbjct 70 LAQVRAEVNNLGAGSSDPMYVALDDAARRFPIPLEAFIELADGVESDVHGTTYDTFDDMV 129 Query 123 VYCRRGAGTIGKLCLSIFGPVSTATSR----YAEQLGIALQQTNILRDVREDFLNGRIYL 178 YCR AGTIG+L L IFG A+ R A+ LG+ALQQTNILRDVRED L GRIYL Sbjct 130 GYCRLVAGTIGRLSLGIFGTEQAASDRSAPAIADALGVALQQTNILRDVREDLLGGRIYL 189 Query 179 PRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACC 238 P EL G+ L +D +G L P L LR SA RA +WY G+ L+ LDRRSAACC Sbjct 190 PAQELKAAGIELAVDASGRLGGPPTALLGYLRSSAQRAEEWYDRGMVLLDLLDRRSAACC 249 Query 239 AAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AM+GIY R I+ PA V DRR++L G +KA VAA +LA Sbjct 250 GAMAGIYLRLNRRIKNEPAAVLDRRLALPGWQKAVVAARSLAG 292 >gi|336177209|ref|YP_004582584.1| squalene synthase HpnD [Frankia symbiont of Datisca glomerata] gi|334858189|gb|AEH08663.1| squalene synthase HpnD [Frankia symbiont of Datisca glomerata] Length=301 Score = 276 bits (706), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 154/283 (55%), Positives = 188/283 (67%), Gaps = 5/283 (1%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 +E+AY E++TR AARNF YGIRLLP +KRAALSAVYA RR+DD+ DG+L E K Sbjct 12 VEEAYASCEALTREAARNFAYGIRLLPVDKRAALSAVYAFARRLDDIGDGDLPLEEKAIR 71 Query 64 LDAIRKSLDNIDD-SSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELI 122 L A R + + SSDPVL+AL DA RRFP+P+ F ELIDG M++ FD+L+ Sbjct 72 LAAARADITGLGAASSDPVLIALDDACRRFPIPVDAFCELIDGVEMDLRGVTYESFDDLV 131 Query 123 VYCRRGAGTIGKLCLSIFGP----VSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYL 178 YCRR AGTIG+L L IFG + A++LGIALQQTNILRDVRED + GRIYL Sbjct 132 EYCRRVAGTIGRLSLGIFGTQAAHADAGAATVADELGIALQQTNILRDVREDLITGRIYL 191 Query 179 PRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACC 238 PR EL++ G+ L L G L P+ L LR A RA +WY GL+L+ LDRRSAACC Sbjct 192 PRAELEKAGITLALGPDGRLGGPEDALVEYLRECAQRADEWYGRGLKLLTMLDRRSAACC 251 Query 239 AAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AM+GIY R IR PA V +R+SL G +KA VAA +LA Sbjct 252 GAMAGIYLRLNRRIRTDPAPVLQQRLSLPGWEKAVVAARSLAG 294 >gi|158317464|ref|YP_001509972.1| squalene/phytoene synthase [Frankia sp. EAN1pec] gi|158112869|gb|ABW15066.1| Squalene/phytoene synthase [Frankia sp. EAN1pec] Length=300 Score = 276 bits (706), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 153/284 (54%), Positives = 192/284 (68%), Gaps = 5/284 (1%) Query 2 TEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKI 61 + + +AY E++TR AARNF YGIRLLP EKR ALSAVYAL RR+DD+ DG+L E K+ Sbjct 9 STVAEAYASCEALTREAARNFSYGIRLLPAEKRGALSAVYALARRLDDIGDGDLPDEEKL 68 Query 62 TELDAIRKSLDNID-DSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 L+ +R + +D +SSDPV+VALAD ARRFPVP+ F EL DG ++ FD+ Sbjct 69 AGLEKVRADVRVLDINSSDPVMVALADTARRFPVPMEAFIELADGVESDVHGVPYETFDD 128 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTA----TSRYAEQLGIALQQTNILRDVREDFLNGRI 176 ++ YCR AGTIG+L L IFG +A ++ A+ LG+ALQQTNILRDVRED LNGRI Sbjct 129 MVGYCRLVAGTIGRLSLGIFGVDGSAGDARSAEIADALGVALQQTNILRDVREDLLNGRI 188 Query 177 YLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAA 236 YLP EL++ GV L + G L P+ L LR A RA +WY+ GL L+ LDRRSAA Sbjct 189 YLPSTELEKAGVTLVVSPAGRLGGPEDALVDYLRDCAARADEWYTRGLALLGLLDRRSAA 248 Query 237 CCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALA 280 CC AM+GIY R IR P V +RR+SL G +KA VAA +LA Sbjct 249 CCGAMAGIYLRLNRRIRQDPTAVLERRLSLPGWEKAVVAARSLA 292 >gi|86739533|ref|YP_479933.1| squalene/phytoene synthase [Frankia sp. CcI3] gi|86566395|gb|ABD10204.1| Squalene/phytoene synthase [Frankia sp. CcI3] Length=304 Score = 266 bits (679), Expect = 4e-69, Method: Compositional matrix adjust. Identities = 155/283 (55%), Positives = 188/283 (67%), Gaps = 6/283 (2%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + +AY E++T+ AARNF YGIRLLP EKR ALSAVYAL RR+DD+ DG+L E K Sbjct 14 VAEAYAACEAVTKEAARNFSYGIRLLPAEKRGALSAVYALARRLDDIGDGDLPEEAKFAG 73 Query 64 LDAIRKSLDNI--DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDEL 121 L +R ++ + + S DPV VALADAARRFP+P+ F EL DG ++ T FD+L Sbjct 74 LAQVRAEVEELGTNSSDDPVFVALADAARRFPIPLEAFIELADGVESDVRGTTYDTFDDL 133 Query 122 IVYCRRGAGTIGKLCLSIFGPVSTATSR----YAEQLGIALQQTNILRDVREDFLNGRIY 177 + YCR AGTIG+L L IFG + R A+ LG+ALQQTNILRDVRED L GRIY Sbjct 134 VGYCRLVAGTIGRLSLGIFGSERATSHRDASGVADALGVALQQTNILRDVREDLLGGRIY 193 Query 178 LPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAAC 237 LPR EL GV L +D TG L P L A LR SA RA +WY GL L+ LDRRSAAC Sbjct 194 LPRQELKAAGVELEVDATGRLGGPPDALIAYLRTSAQRAEEWYGRGLVLLDLLDRRSAAC 253 Query 238 CAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALA 280 C AM+GIY R I+ P+ V DRR++L G +KA VAA +LA Sbjct 254 CGAMAGIYLRLNRRIKTDPSAVLDRRLALPGWEKAVVAARSLA 296 >gi|288922393|ref|ZP_06416583.1| squalene synthase HpnD [Frankia sp. EUN1f] gi|288346264|gb|EFC80603.1| squalene synthase HpnD [Frankia sp. EUN1f] Length=300 Score = 260 bits (665), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 153/284 (54%), Positives = 191/284 (68%), Gaps = 5/284 (1%) Query 2 TEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKI 61 + + +AY E++TR AARNF YGIRLLP EKR ALSAVYAL RR+DD+ DG+L E K+ Sbjct 9 STVAEAYASCEALTREAARNFSYGIRLLPAEKRGALSAVYALARRLDDIGDGDLPAEEKL 68 Query 62 TELDAIRKSLDNID-DSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 L +R + +D +SSDPV+VALAD ARRFP+PI F EL DG ++ F++ Sbjct 69 AGLAKVRADIRALDTNSSDPVMVALADTARRFPIPIEAFIELTDGVESDVHGATYETFED 128 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTA----TSRYAEQLGIALQQTNILRDVREDFLNGRI 176 ++ YCR AGTIG+L L IFG +A + A+ LG+ALQQTNILRDVRED LNGRI Sbjct 129 MVGYCRLVAGTIGRLSLGIFGLEGSAGDARAAEIADALGVALQQTNILRDVREDLLNGRI 188 Query 177 YLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAA 236 YLP EL++ GV L +D G L P+ L LR A RA +WY+ GL L+ LDRRSAA Sbjct 189 YLPSTELEKAGVTLTVDAAGRLGAPEDALVDYLRDCAVRADEWYARGLALLGLLDRRSAA 248 Query 237 CCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALA 280 CC AM+GIY R IR P V +RR+SL G +KA VAA +LA Sbjct 249 CCGAMAGIYLRLNRRIRQDPTAVLERRLSLPGWEKAVVAARSLA 292 >gi|331697461|ref|YP_004333700.1| squalene synthase HpnD [Pseudonocardia dioxanivorans CB1190] gi|326952150|gb|AEA25847.1| squalene synthase HpnD [Pseudonocardia dioxanivorans CB1190] Length=310 Score = 259 bits (663), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 156/293 (54%), Positives = 197/293 (68%), Gaps = 22/293 (7%) Query 2 TEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDV----------A 51 T +E AY TE+ITR ARNFYYGIRLLP KR+AL AVYAL RRIDD+ Sbjct 7 TALELAYARTEAITREQARNFYYGIRLLPPAKRSALCAVYALARRIDDIGDGDAGGDPGT 66 Query 52 DGELAPETKITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEI- 110 + +LA ++ E ++R++ + D+SD VLVA+ DAARR+P+P+ F EL+DG ++ Sbjct 67 EAKLAALGRVRE--SVRRAREQDPDASDAVLVAVTDAARRYPIPLGAFDELVDGVEADVR 124 Query 111 --DWTG----CRDFDELIVYCRRGAGTIGKLCLSIFG--PVSTATSRYAEQLGIALQQTN 162 D G FD+++ YCR+ AG++G+LCL IFG P A +A+ LGIALQQTN Sbjct 125 MDDVPGESAPYATFDDMVGYCRQVAGSVGRLCLGIFGSRPDPRAPG-FADALGIALQQTN 183 Query 163 ILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSL 222 ILRD+RED NGRIYLP +EL R V LRLD+ G L D G LA L+RFSA RA +WY+ Sbjct 184 ILRDIREDLQNGRIYLPTEELARFDVDLRLDEHGNLVDKTGGLAELIRFSAARAREWYAD 243 Query 223 GLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVA 275 GLRL+P LDRRSAAC AM+GIYR+ L I A P VY +R SLSG +K VA Sbjct 244 GLRLVPLLDRRSAACATAMAGIYRQLLDDIAADPPSVYHQRRSLSGRQKIGVA 296 >gi|312199713|ref|YP_004019774.1| squalene synthase HpnD [Frankia sp. EuI1c] gi|311231049|gb|ADP83904.1| squalene synthase HpnD [Frankia sp. EuI1c] Length=309 Score = 251 bits (641), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 148/282 (53%), Positives = 186/282 (66%), Gaps = 5/282 (1%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + +AY E IT+ AA+NF YGIRLLP ++RAALSAVYA RR+DD+ DG+L + K+ Sbjct 10 VTEAYAACEEITKQAAKNFSYGIRLLPADRRAALSAVYAFSRRLDDIGDGDLPDDQKVEG 69 Query 64 LDAIRKSLDNID-DSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELI 122 L R + +D +SSDPVLVALADAA+RFP+P+ F EL DG +I + FD+++ Sbjct 70 LAKARADIRGLDPNSSDPVLVALADAAKRFPIPLEAFIELADGVESDIVPSTYDTFDDMV 129 Query 123 VYCRRGAGTIGKLCLSIFGPVSTATSR----YAEQLGIALQQTNILRDVREDFLNGRIYL 178 YCR AGTIG+L L IFG A+ R A+ LG+ALQQTNILRDVRED L GR YL Sbjct 130 GYCRLVAGTIGRLSLGIFGTTEAASRRDAPAIADALGVALQQTNILRDVREDLLGGRTYL 189 Query 179 PRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACC 238 P+ EL GV+L +D G L P L LR RA +WYS GL L+ LDRRSAACC Sbjct 190 PQAELAAAGVKLAVDADGVLGGPRDALVDYLRMGTARAEEWYSRGLVLLDLLDRRSAACC 249 Query 239 AAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALA 280 A++GIY R I+A PA V +R+SL +KA VAA +LA Sbjct 250 GALAGIYLRLNRRIQAEPAAVLTQRVSLPAREKALVAARSLA 291 >gi|134100863|ref|YP_001106524.1| putative squalene/phytoene synthase [Saccharopolyspora erythraea NRRL 2338] gi|133913486|emb|CAM03599.1| putative squalene/phytoene synthase [Saccharopolyspora erythraea NRRL 2338] Length=297 Score = 248 bits (633), Expect = 9e-64, Method: Compositional matrix adjust. Identities = 142/280 (51%), Positives = 179/280 (64%), Gaps = 2/280 (0%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 I +AY E IT ARNF YGIRLLP KR ALSAVYA RR+DD+ DG+L E K+ Sbjct 15 IREAYAECERITGEQARNFSYGIRLLPGPKRRALSAVYAFARRVDDIGDGDLPCEEKLRR 74 Query 64 LDAIRKSLDNID-DSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELI 122 L R ++ + DSSDPV+VALA A+R P+P++ F ELIDG ++ F EL+ Sbjct 75 LKQARVAVHSATVDSSDPVVVALAATAQRMPIPLSAFDELIDGCESDVRGATYDTFAELV 134 Query 123 VYCRRGAGTIGKLCLSIFGPVSTATSR-YAEQLGIALQQTNILRDVREDFLNGRIYLPRD 181 YCR AG++G+L L +FG +A +R A+ LG+ALQ TNILRDVREDF NGR+YLP Sbjct 135 HYCRCVAGSVGRLSLGVFGAADSAEARPRADALGVALQLTNILRDVREDFGNGRVYLPAA 194 Query 182 ELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAM 241 +L+R GV + D G L + AL+ + A RA WY++GL L+P LDRRS ACCAAM Sbjct 195 DLERFGVGMEADRRGDLRIDEPGWNALIEYQAQRAELWYAVGLGLLPLLDRRSRACCAAM 254 Query 242 SGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 +GIY L I A P R+SL KKA VAA +LA Sbjct 255 AGIYHELLHRIAAEPHQALSGRMSLPAWKKAGVAARSLAG 294 >gi|291003523|ref|ZP_06561496.1| probable phytoene synthase [Saccharopolyspora erythraea NRRL 2338] Length=290 Score = 248 bits (632), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 142/279 (51%), Positives = 179/279 (65%), Gaps = 2/279 (0%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 I +AY E IT ARNF YGIRLLP KR ALSAVYA RR+DD+ DG+L E K+ Sbjct 8 IREAYAECERITGEQARNFSYGIRLLPGPKRRALSAVYAFARRVDDIGDGDLPCEEKLRR 67 Query 64 LDAIRKSLDNID-DSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELI 122 L R ++ + DSSDPV+VALA A+R P+P++ F ELIDG ++ F EL+ Sbjct 68 LKQARVAVHSATVDSSDPVVVALAATAQRMPIPLSAFDELIDGCESDVRGATYDTFAELV 127 Query 123 VYCRRGAGTIGKLCLSIFGPVSTATSR-YAEQLGIALQQTNILRDVREDFLNGRIYLPRD 181 YCR AG++G+L L +FG +A +R A+ LG+ALQ TNILRDVREDF NGR+YLP Sbjct 128 HYCRCVAGSVGRLSLGVFGAADSAEARPRADALGVALQLTNILRDVREDFGNGRVYLPAA 187 Query 182 ELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAM 241 +L+R GV + D G L + AL+ + A RA WY++GL L+P LDRRS ACCAAM Sbjct 188 DLERFGVGMEADRRGDLRIDEPGWNALIEYQAQRAELWYAVGLGLLPLLDRRSRACCAAM 247 Query 242 SGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALA 280 +GIY L I A P R+SL KKA VAA +LA Sbjct 248 AGIYHELLHRIAAEPHQALSGRMSLPAWKKAGVAARSLA 286 >gi|117928901|ref|YP_873452.1| squalene/phytoene synthase [Acidothermus cellulolyticus 11B] gi|117649364|gb|ABK53466.1| Squalene/phytoene synthase [Acidothermus cellulolyticus 11B] Length=303 Score = 247 bits (631), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 139/270 (52%), Positives = 174/270 (65%), Gaps = 2/270 (0%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + AY E I +AARNF YGIRLLP KR AL+AVYAL RRIDD+ DG L + K+ Sbjct 9 LATAYAECEHIMVSAARNFSYGIRLLPPGKRQALAAVYALARRIDDIGDGTLPDDEKLRL 68 Query 64 LDAIRKSLDNIDD-SSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELI 122 LD +R S+ + + + DPVL+A+ DAARR P+PI F ELI+G +++ T F EL Sbjct 69 LDDVRMSIKRMGEPTDDPVLLAVGDAARRLPIPIDAFFELIEGCELDVRNTRYPTFRELT 128 Query 123 VYCRRGAGTIGKLCLSIFGPVSTATSR-YAEQLGIALQQTNILRDVREDFLNGRIYLPRD 181 YCR AG+IG+L L +F P AT+ A+ LGIALQ TNILRD+RED L GR+YLP D Sbjct 129 HYCRCVAGSIGRLSLGVFDPADFATAEPLADALGIALQLTNILRDIREDLLRGRVYLPLD 188 Query 182 ELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAM 241 EL G+ LDD G + D GR A +R A RA WY+ G L+P LDRRSAAC AAM Sbjct 189 ELTAAGIEPHLDDRGMVADERGRFAEFIRDQAARAETWYARGFALLPMLDRRSAACTAAM 248 Query 242 SGIYRRQLALIRASPAVVYDRRISLSGLKK 271 +GIY R L I +P V RR++L +K Sbjct 249 AGIYHRLLQRIARNPRAVLQRRVALPAWEK 278 >gi|326775275|ref|ZP_08234540.1| squalene synthase HpnD [Streptomyces cf. griseus XylebKG-1] gi|326655608|gb|EGE40454.1| squalene synthase HpnD [Streptomyces griseus XylebKG-1] Length=317 Score = 243 bits (621), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 140/289 (49%), Positives = 176/289 (61%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DGEL PETK T Sbjct 16 VQAAYSYCEAVTGQQARNFAYGIRLLPYEKRQAMSALYAFSRRVDDIGDGELDPETKRTR 75 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L++ R+ L+ I +D +DPV VALADAA+RFP+P+ ELIDG M++ Sbjct 76 LESTRELLERIRKDAVDEDDTDPVAVALADAAQRFPLPLGGLDELIDGVLMDVRGATYET 135 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG A + YA+ LG+ALQ TNILRDVRED Sbjct 136 WDDLKAYCRCVAGAIGRLSLGVFGTAPGARGAERAAEYADTLGLALQLTNILRDVREDAG 195 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G T P A L+ F RA ++ G RL+P LDR Sbjct 196 NGRTYLPTDDLAKFGCSAGFHRT--TPPPGSDFAGLIHFEVRRARALFAEGYRLLPMLDR 253 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 254 RSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSG 302 >gi|182434758|ref|YP_001822477.1| putative squalene/phytoene synthase [Streptomyces griseus subsp. griseus NBRC 13350] gi|178463274|dbj|BAG17794.1| putative squalene/phytoene synthase [Streptomyces griseus subsp. griseus NBRC 13350] Length=317 Score = 243 bits (620), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 140/289 (49%), Positives = 176/289 (61%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DGEL PETK T Sbjct 16 VQAAYSYCEAVTGQQARNFAYGIRLLPYEKRQAMSALYAFSRRVDDIGDGELDPETKRTR 75 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L++ R+ L+ I +D +DPV VALADAA+RFP+P+ ELIDG M++ Sbjct 76 LESTRELLERIRKEAVDEDDTDPVAVALADAAQRFPLPLGGLDELIDGVLMDVRGATYET 135 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG A + YA+ LG+ALQ TNILRDVRED Sbjct 136 WDDLKAYCRCVAGAIGRLSLGVFGTAPGARGAERAAEYADTLGLALQLTNILRDVREDAG 195 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G T P A L+ F RA ++ G RL+P LDR Sbjct 196 NGRTYLPADDLAKFGCSAGFHRT--TPPPGSDFAGLIHFEVRRARALFAEGYRLLPMLDR 253 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 254 RSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSG 302 >gi|257056314|ref|YP_003134146.1| squalene synthase HpnD [Saccharomonospora viridis DSM 43017] gi|256586186|gb|ACU97319.1| squalene synthase HpnD [Saccharomonospora viridis DSM 43017] Length=288 Score = 242 bits (617), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 152/286 (54%), Positives = 180/286 (63%), Gaps = 9/286 (3%) Query 5 EQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITEL 64 EQAY ITR ARNF YGIRLLP KR ALSAVYA RRIDD+ DG+L+ E K+ L Sbjct 4 EQAYDDCVRITREQARNFAYGIRLLPGPKRNALSAVYAFARRIDDIGDGDLSREVKLKGL 63 Query 65 DAIRKSLDNID----DSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 + R L ++ D+ DPVL+ALADAARRF +P+ F ELIDG R ++ G F Sbjct 64 ETARADLRAMEAGTTDTDDPVLIALADAARRFELPLDAFDELIDGCRADVLGVGYPTFTS 123 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTATSRY---AEQLGIALQQTNILRDVREDFLNGRIY 177 L YCR AG++G+L L++FG S RY A+ LG+ALQ TNILRDV ED NGR+Y Sbjct 124 LERYCRCVAGSVGRLSLAVFG--SPDRDRYEPIADDLGVALQLTNILRDVVEDLDNGRVY 181 Query 178 LPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAAC 237 LP DEL R G L DD+GA D LAALL F A RA +WY GL L+ LDRRS AC Sbjct 182 LPADELKRFGCTLERDDSGAFVDDADDLAALLEFQAVRAQEWYERGLALLDVLDRRSRAC 241 Query 238 CAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASSV 283 CAAM+GIY R L + P +V R SL +KA VA ALA Sbjct 242 CAAMAGIYHRLLTRMALRPDLVLRGRTSLPSWEKALVAGMALAGGT 287 >gi|291449097|ref|ZP_06588487.1| squalene/phytoene synthase [Streptomyces roseosporus NRRL 15998] gi|291352044|gb|EFE78948.1| squalene/phytoene synthase [Streptomyces roseosporus NRRL 15998] Length=313 Score = 240 bits (613), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 139/289 (49%), Positives = 174/289 (61%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DGEL TK T Sbjct 12 VQAAYSYCEAVTGQQARNFAYGIRLLPNEKRQAMSALYAFSRRVDDIGDGELDAGTKRTR 71 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L++ R+ LD + +D +DPV VALADAARRFP+P+ ELIDG M++ Sbjct 72 LESTRELLDRVRHGKVEEDDTDPVAVALADAARRFPLPLGGLDELIDGVLMDVRGATYET 131 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG A + YA+ LG+ALQ TNILRDVRED Sbjct 132 WDDLKTYCRCVAGAIGRLSLGVFGTAPGARGAERAAEYADTLGLALQLTNILRDVREDAG 191 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G T P A L+ F RA ++ G RL+P LDR Sbjct 192 NGRTYLPADDLAKFGCSAGFHRT--TPPPGSDFAGLIHFEVRRARALFAEGYRLLPMLDR 249 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 250 RSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSG 298 >gi|239992109|ref|ZP_04712773.1| putative squalene/phytoene synthase [Streptomyces roseosporus NRRL 11379] Length=317 Score = 240 bits (613), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 139/289 (49%), Positives = 174/289 (61%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DGEL TK T Sbjct 16 VQAAYSYCEAVTGQQARNFAYGIRLLPNEKRQAMSALYAFSRRVDDIGDGELDAGTKRTR 75 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L++ R+ LD + +D +DPV VALADAARRFP+P+ ELIDG M++ Sbjct 76 LESTRELLDRVRHGKVEEDDTDPVAVALADAARRFPLPLGGLDELIDGVLMDVRGATYET 135 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG A + YA+ LG+ALQ TNILRDVRED Sbjct 136 WDDLKTYCRCVAGAIGRLSLGVFGTAPGARGAERAAEYADTLGLALQLTNILRDVREDAG 195 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G T P A L+ F RA ++ G RL+P LDR Sbjct 196 NGRTYLPADDLAKFGCSAGFHRT--TPPPGSDFAGLIHFEVRRARALFAEGYRLLPMLDR 253 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 254 RSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSG 302 >gi|328886495|emb|CCA59734.1| Phytoene synthase [Streptomyces venezuelae ATCC 10712] Length=316 Score = 240 bits (612), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 142/290 (49%), Positives = 178/290 (62%), Gaps = 15/290 (5%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DG LAPE K Sbjct 15 VQAAYSYCEAVTGQQARNFAYGIRLLPTEKRQAMSALYAFSRRVDDIGDGTLAPEAKRER 74 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+A R LD + +D +DPV VALAD+ARRFP+P+ ELIDG M++ Sbjct 75 LEATRALLDRVRTGGVDEDDTDPVAVALADSARRFPIPLGGLDELIDGVLMDVRGETYET 134 Query 118 FDELIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFL 172 +D+L VYCR AG IG++ L +FG P + R YA+ LG+ALQ TNILRDVRED Sbjct 135 WDDLKVYCRCVAGAIGRISLGVFGTQPGARGADRAPEYADTLGLALQLTNILRDVREDAG 194 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLD 231 NGR YLP D+L + G D G+ P G A L+ F RA ++ G RL+P LD Sbjct 195 NGRTYLPADDLAKFGC---ADGFGSDTPPAGADFAGLVHFEVRRARALFAEGYRLLPMLD 251 Query 232 RRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RRS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 252 RRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|320007259|gb|ADW02109.1| squalene synthase HpnD [Streptomyces flavogriseus ATCC 33331] Length=314 Score = 239 bits (610), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 139/289 (49%), Positives = 172/289 (60%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DGEL PETK Sbjct 12 VQAAYSYCEAVTGQQARNFAYGIRLLPYEKRQAMSALYAFSRRVDDIGDGELDPETKHVR 71 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R L I +D +DPV VALADA RRFP+P+ ELIDG M++ Sbjct 72 LEETRGLLGRIRDGAVDEDDTDPVAVALADATRRFPLPLGGLDELIDGVLMDVRGATYET 131 Query 118 FDELIVYCRRGAGTIGKLCLSIFG-----PVSTATSRYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG P + + YA+ LG+ALQ TNILRDVRED Sbjct 132 WDDLKTYCRCVAGAIGRLSLGVFGTQPGAPGAERAAEYADTLGLALQLTNILRDVREDAG 191 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G A P A L+ F RA ++ G RL+P LDR Sbjct 192 NGRTYLPADDLAKFGCSAGFHR--ATPPPGSDFAGLVHFEVRRARALFAEGYRLLPMLDR 249 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 250 RSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSG 298 >gi|256395790|ref|YP_003117354.1| squalene synthase HpnD [Catenulispora acidiphila DSM 44928] gi|256362016|gb|ACU75513.1| squalene synthase HpnD [Catenulispora acidiphila DSM 44928] Length=287 Score = 238 bits (608), Expect = 6e-61, Method: Compositional matrix adjust. Identities = 149/280 (54%), Positives = 182/280 (65%), Gaps = 4/280 (1%) Query 5 EQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITEL 64 + AY E + R+ ARNF YGIRLLP KR ALSAVYA RR+DD+ DG ++T+L Sbjct 4 QAAYEHCERVVRSRARNFAYGIRLLPTTKRQALSAVYAFARRVDDIGDGSETRGERLTQL 63 Query 65 DAIRKSLDNIDDS-SDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIV 123 A R+ L ID+ DPVLVALADAAR+ P+P+A F ELIDG ++ T D+L Sbjct 64 AAAREELHRIDEHPEDPVLVALADAARQHPIPLAAFDELIDGCEADVRGTDYATADQLTF 123 Query 124 YCRRGAGTIGKLCLSIFG--PV-STATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPR 180 YCR AG+IG+L L ++G P S YA+ LG+ALQ TNILRD+RED L GR+YLP Sbjct 124 YCRCVAGSIGRLSLGVYGVDPARQKEASGYADSLGVALQLTNILRDIREDGLMGRVYLPA 183 Query 181 DELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAA 240 DEL R G L++D+ G D D LAAL+R A RA WY GLRL+P LDRRSAAC AA Sbjct 184 DELVRHGCTLKIDEHGRFVDDDADLAALVRDQAARARAWYDEGLRLLPLLDRRSAACTAA 243 Query 241 MSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALA 280 M+GIYRR L I P + R+SL +K VAA ALA Sbjct 244 MAGIYRRLLIRIAEQPISALNARMSLPAWEKGVVAARALA 283 >gi|345003393|ref|YP_004806247.1| squalene synthase HpnD [Streptomyces sp. SirexAA-E] gi|344319019|gb|AEN13707.1| squalene synthase HpnD [Streptomyces sp. SirexAA-E] Length=313 Score = 236 bits (603), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 138/289 (48%), Positives = 173/289 (60%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG L PETK T Sbjct 12 VQAAYSYCEAVTGQQARNFAYGIRLLPYAKRQAMSALYAFSRRVDDIGDGALEPETKRTR 71 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R+ LD I +D +DPV VALADAARRFP+P+ ELIDG M++ Sbjct 72 LEGTRELLDRIREGAVDEDDTDPVAVALADAARRFPLPLGGLDELIDGVLMDVRGEHYET 131 Query 118 FDELIVYCRRGAGTIGKLCLSIFG-----PVSTATSRYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG P + + YA+ LG+ALQ TNILRDVRED Sbjct 132 WDDLRTYCRCVAGAIGRLSLGVFGTEPGVPGADRAAEYADTLGLALQLTNILRDVREDAG 191 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G D A L+ + RA ++ G RL+P LDR Sbjct 192 NGRTYLPADDLAKFGCSEGFHRATPPAGSD--FAGLVHYEVRRARALFAEGYRLLPMLDR 249 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 250 RSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSG 298 >gi|311895178|dbj|BAJ27586.1| putative phytoene synthase [Kitasatospora setae KM-6054] Length=296 Score = 235 bits (599), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 136/286 (48%), Positives = 175/286 (62%), Gaps = 9/286 (3%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + AYR E++T ARNF YGIRLLP KR A+SA+YAL RR+DD+ DGEL E K Sbjct 11 VMAAYRYCEAVTALQARNFSYGIRLLPEAKRLAMSALYALARRVDDIGDGELPAEQKAEA 70 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L R LD + ++ +DP+ VALADAARRFP+P+ F EL+DG M++ + Sbjct 71 LARTRVLLDEVRAGEVGEEDTDPIKVALADAARRFPIPLGGFDELVDGVEMDLKGVEYTN 130 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTA-TSRYAEQLGIALQQTNILRDVREDFLNGRI 176 +DEL VYCR AG++G+L L ++G + YA+ LG+ALQ TNILRD+RED LNGR Sbjct 131 YDELKVYCRCVAGSVGRLSLGVYGCEDWERGAEYADTLGLALQLTNILRDLREDALNGRT 190 Query 177 YLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAA 236 YLP ++L R G + D L+ F A+RA + GLRL+P LDRRS A Sbjct 191 YLPTEDLVRFGCQQGFALPALPVGAD--FTGLVAFEAERAQAAFEEGLRLLPMLDRRSRA 248 Query 237 CCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASS 282 AAM+GIY R L I A P V R+SL G +KA VA + LA Sbjct 249 ATAAMAGIYHRLLGRIAADPHAVLRGRVSLPGWEKAYVALSGLAGG 294 >gi|297190553|ref|ZP_06907951.1| phytoene synthase [Streptomyces pristinaespiralis ATCC 25486] gi|197717867|gb|EDY61775.1| phytoene synthase [Streptomyces pristinaespiralis ATCC 25486] Length=313 Score = 233 bits (595), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 135/289 (47%), Positives = 171/289 (60%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG L P+ K Sbjct 12 VQAAYSYCEAVTGQQARNFAYGIRLLPPHKRQAMSALYAFSRRVDDIGDGTLKPQAKQDR 71 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+A R+ LD I +D +DPV VAL DAARRFP+P+ ELIDG M++ Sbjct 72 LEATRELLDRIRQGAVDEDDTDPVAVALCDAARRFPLPLGGLDELIDGVLMDVRGETYET 131 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG A + YA+ LG+ALQ TNILRD+ ED Sbjct 132 WDDLKAYCRCVAGAIGRLSLGVFGTQPGARGADRAAEYADTLGLALQLTNILRDIAEDAS 191 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G + G P A L+ F RA ++ G RL+P LDR Sbjct 192 NGRTYLPADDLAKFGCSEGFN--GTTPPPGSDFAGLVHFEVRRARALFAEGYRLLPMLDR 249 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 250 RSGACVAAMAGIYRRLLDRIERDPDAVLRGRVSLPGREKAYVAVRGLSG 298 >gi|219964680|gb|ACL68404.1| squalene/phytoene synthase [Streptomyces peucetius ATCC 27952] Length=316 Score = 233 bits (593), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 135/289 (47%), Positives = 170/289 (59%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG L P+ K Sbjct 15 VQAAYSYCEAVTGQQARNFAYGIRLLPTHKRQAMSALYAFSRRVDDIGDGTLKPQAKQDR 74 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R+ L+ I +D +DPV VAL+DAARRFP+P+ ELIDG M++ Sbjct 75 LEGTRELLERIRRGAVDEDDTDPVAVALSDAARRFPLPLGGLDELIDGVLMDVRGESYET 134 Query 118 FDELIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFL 172 +D+L VYCR AG IG+L L +FG P R YA+ LG+ALQ TNILRDV ED Sbjct 135 WDDLKVYCRCVAGAIGRLSLGVFGTQPGVRGAERAAEYADTLGLALQLTNILRDVTEDAA 194 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G G P L+ F RA ++ G RL+P LDR Sbjct 195 NGRTYLPADDLAKFGCSEGFH--GTTPPPGADFTGLVHFEVRRARALFAEGYRLLPMLDR 252 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 253 RSGACVAAMAGIYRRLLDRIEREPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|289767674|ref|ZP_06527052.1| squalene synthase HpnD [Streptomyces lividans TK24] gi|289697873|gb|EFD65302.1| squalene synthase HpnD [Streptomyces lividans TK24] Length=316 Score = 232 bits (591), Expect = 6e-59, Method: Compositional matrix adjust. Identities = 138/286 (49%), Positives = 172/286 (61%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG LA + K+T LD Sbjct 18 AYSYCEAVTGQQARNFAYGIRLLPTPKRRAMSALYAFSRRVDDIGDGVLADDVKVTRLDE 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L I +D +DPV VALADAARRFP+P+ ELIDG +M++ +D+ Sbjct 78 TRAVLARIQDGAVEEDDTDPVAVALADAARRFPIPLGGLDELIDGVQMDLRGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFLNGR 175 L VYCR AG IG+L L +FG P + R YA+ LG+ALQ TNILRDVRED GR Sbjct 138 LKVYCRCVAGAIGRLSLGVFGTEPGARGAERAPEYADTLGLALQLTNILRDVREDAEGGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G + + D A L+ F RA ++ G RL+P LDRRS Sbjct 198 TYLPADDLAKFGCAAGFNGPTPPEGSD--FAGLVHFEVRRARALFAEGYRLLPMLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 256 ACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|318058276|ref|ZP_07976999.1| probable phytoene synthase [Streptomyces sp. SA3_actG] gi|318076938|ref|ZP_07984270.1| probable phytoene synthase [Streptomyces sp. SA3_actF] Length=312 Score = 231 bits (590), Expect = 8e-59, Method: Compositional matrix adjust. Identities = 137/290 (48%), Positives = 170/290 (59%), Gaps = 15/290 (5%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + AY E++T A+NF YGIRLLP +KR A+SAVYA RR+DD+ DG LAPE K Sbjct 11 VSAAYGYCETVTGAEAKNFAYGIRLLPGDKRRAMSAVYAFSRRVDDIGDGTLAPEEKTRR 70 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R+ L+ + +D +DPV VALAD ARRFPVP+ ELIDG M++ R Sbjct 71 LNECRELLERVRTKDVAEDDTDPVAVALADTARRFPVPLGALDELIDGVLMDVQGRAYRT 130 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTATSR-----YAEQLGIALQQTNILRDVREDFL 172 +DEL YCR AG IG+L L IFG A R YA LG+ALQ TNILRDVRED Sbjct 131 WDELADYCRCVAGAIGRLSLGIFGVRPGARDRVHAPEYANTLGLALQLTNILRDVREDAA 190 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLD 231 NGR YLP ++LD+ G G+ P+G L+ F RA + G +L+P LD Sbjct 191 NGRTYLPAEDLDKFGCSAGF---GSATLPEGADFPGLVHFEVRRARALFDEGYQLLPMLD 247 Query 232 RRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RR AC +AM+GIY R L I P V R+SL +KA VA LA Sbjct 248 RRGGACVSAMAGIYHRLLDRIEQDPDAVLRGRVSLPAHEKAYVAVRGLAG 297 >gi|295835548|ref|ZP_06822481.1| squalene synthase HpnD [Streptomyces sp. SPB74] gi|295825547|gb|EDY46374.2| squalene synthase HpnD [Streptomyces sp. SPB74] Length=316 Score = 230 bits (587), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 137/290 (48%), Positives = 169/290 (59%), Gaps = 15/290 (5%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + AY ES+T A+NF YGIRLLP +KR A+SAVYA RR+DD+ DG L PE K Sbjct 15 VNAAYGYCESVTGAEAKNFAYGIRLLPGDKRRAMSAVYAFSRRVDDIGDGTLVPEEKTRR 74 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R L+ + +D +DPV VALAD A RFPVP+ ELIDG M++ R Sbjct 75 LNECRALLERVRAKDVAEDDTDPVAVALADTALRFPVPLGALDELIDGVLMDVQGRAYRT 134 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTATSR-----YAEQLGIALQQTNILRDVREDFL 172 +DEL YCR AG IG+L L +FG +A R YA LG+ALQ TNILRDVRED Sbjct 135 WDELADYCRCVAGAIGRLSLGVFGVRVSARDRVRAPEYANTLGLALQLTNILRDVREDAG 194 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLD 231 NGR YLP ++LD+ G G+ P+G A L+ F RA + G RL+P LD Sbjct 195 NGRTYLPAEDLDKFGCSAGF---GSATLPEGADFAGLVHFEVRRARALFEEGYRLLPMLD 251 Query 232 RRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RR AC +AM+GIY R L I P V R+SL +KA VA LA Sbjct 252 RRGGACVSAMAGIYHRLLDRIEQDPDAVLRGRVSLPAREKAYVAVRGLAG 301 >gi|302522952|ref|ZP_07275294.1| squalene synthase HpnD [Streptomyces sp. SPB78] gi|302431847|gb|EFL03663.1| squalene synthase HpnD [Streptomyces sp. SPB78] Length=312 Score = 230 bits (587), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 137/290 (48%), Positives = 169/290 (59%), Gaps = 15/290 (5%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + AY E++T A+NF YGIRLLP +KR A+SAVYA RR+DD+ DG LAPE K Sbjct 11 VSAAYGYCETVTGAEAKNFAYGIRLLPGDKRRAMSAVYAFSRRVDDIGDGTLAPEEKTRR 70 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R+ L + +D +DPV VALAD ARRFPVP+ ELIDG M++ R Sbjct 71 LNECRELLQRVRTKDVAEDDTDPVAVALADTARRFPVPLGALDELIDGVLMDVQGRAYRT 130 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTATSR-----YAEQLGIALQQTNILRDVREDFL 172 +DEL YCR AG IG+L L IFG A R YA LG+ALQ TNILRDVRED Sbjct 131 WDELADYCRCVAGAIGRLSLGIFGVRPGARDRVRAPEYANTLGLALQLTNILRDVREDAA 190 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLD 231 NGR YLP ++LD+ G G+ P+G L+ F RA + G +L+P LD Sbjct 191 NGRTYLPAEDLDKFGCSAGF---GSATLPEGADFPGLVHFEVRRARALFDEGYQLLPMLD 247 Query 232 RRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RR AC +AM+GIY R L I P V R+SL +KA VA LA Sbjct 248 RRGGACVSAMAGIYHRLLDRIEQDPDAVLRGRVSLPAREKAYVAVRGLAG 297 >gi|294816064|ref|ZP_06774707.1| Putative squalene/phytoene synthase [Streptomyces clavuligerus ATCC 27064] gi|326444406|ref|ZP_08219140.1| probable phytoene synthase [Streptomyces clavuligerus ATCC 27064] gi|294328663|gb|EFG10306.1| Putative squalene/phytoene synthase [Streptomyces clavuligerus ATCC 27064] Length=317 Score = 230 bits (587), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 137/289 (48%), Positives = 170/289 (59%), Gaps = 13/289 (4%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 ++ AY E++T ARNF YGIRLLP +KR A+SA+YAL RR+DD+ DG LAP K Sbjct 15 VQAAYSYCEAVTGAQARNFAYGIRLLPTDKRQAMSALYALSRRVDDIGDGTLAPAAKRER 74 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L A R+ L + DD +DPV VALAD ARRFPVP+ ELIDG M++ Sbjct 75 LQATRELLARVRAGAVADDDTDPVAVALADTARRFPVPLDALDELIDGVLMDVRGATYET 134 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTATS-----RYAEQLGIALQQTNILRDVREDFL 172 +D+L YCR AG IG+L L +FG S A YA+ LG+ALQ TNILRD+RED Sbjct 135 WDDLRAYCRCVAGAIGRLSLGVFGTQSGAPGAERAPEYADTLGLALQLTNILRDLREDAA 194 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDR 232 NGR YLP D+L + G D A L+ + RA ++ G RL+P LDR Sbjct 195 NGRTYLPADDLAKFGCSAGFHTPVPPAGSD--FAGLVHYEVRRARALFAEGYRLLPLLDR 252 Query 233 RSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RS AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 253 RSGACVAAMAGIYRRLLDRIERDPGAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|21225053|ref|NP_630832.1| phytoene synthase [Streptomyces coelicolor A3(2)] gi|4539164|emb|CAB39693.1| putative phytoene synthase [Streptomyces coelicolor A3(2)] Length=312 Score = 230 bits (586), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 137/286 (48%), Positives = 172/286 (61%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF +GIRLLP KR A+SA+YA RR+DD+ DG LA + K+T LD Sbjct 14 AYSYCEAVTGQQARNFAHGIRLLPTPKRRAMSALYAFSRRVDDIGDGVLADDVKVTRLDE 73 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L I +D +DPV VALADAARRFP+P+ ELIDG +M++ +D+ Sbjct 74 TRAVLARIQDGAVEEDDTDPVAVALADAARRFPIPLGGLDELIDGVQMDLRGETYETWDD 133 Query 121 LIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFLNGR 175 L VYCR AG IG+L L +FG P + R YA+ LG+ALQ TNILRDVRED GR Sbjct 134 LKVYCRCVAGAIGRLSLGVFGTEPGARGAERAPEYADTLGLALQLTNILRDVREDAEGGR 193 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G + + D A L+ F RA ++ G RL+P LDRRS Sbjct 194 TYLPADDLAKFGCAAGFNGPTPPEGSD--FAGLVHFEVRRARALFAEGYRLLPMLDRRSG 251 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 252 ACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREKAYVAVRGLSG 297 >gi|333023209|ref|ZP_08451273.1| putative squalene/phytoene synthase [Streptomyces sp. Tu6071] gi|332743061|gb|EGJ73502.1| putative squalene/phytoene synthase [Streptomyces sp. Tu6071] Length=312 Score = 230 bits (586), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 137/290 (48%), Positives = 169/290 (59%), Gaps = 15/290 (5%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 + AY E++T A+NF YGIRLLP +KR A+SAVYA RR+DD+ DG LAPE K Sbjct 11 VSAAYGYCETVTGAEAKNFAYGIRLLPGDKRRAMSAVYAFSRRVDDIGDGTLAPEEKTRR 70 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R L+ + +D +DPV VALAD ARRFPVP+ ELIDG M++ R Sbjct 71 LNECRALLERVRTKDVAEDDTDPVAVALADTARRFPVPLGALDELIDGVLMDVQGRAYRT 130 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTATSR-----YAEQLGIALQQTNILRDVREDFL 172 +DEL YCR AG IG+L L IFG A R YA LG+ALQ TNILRDVRED Sbjct 131 WDELADYCRCVAGAIGRLSLGIFGVRPGARDRVRAPEYANTLGLALQLTNILRDVREDAA 190 Query 173 NGRIYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLD 231 NGR YLP ++LD+ G G+ P+G L+ F RA + G +L+P LD Sbjct 191 NGRTYLPAEDLDKFGCSAGF---GSATLPEGADFPGLVHFEVRRARALFDEGYQLLPMLD 247 Query 232 RRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RR AC +AM+GIY R L I P V R+SL +KA VA LA Sbjct 248 RRGGACVSAMAGIYHRLLDRIEQDPDAVLRGRVSLPAREKAYVAVRGLAG 297 >gi|302541343|ref|ZP_07293685.1| squalene synthase HpnD [Streptomyces hygroscopicus ATCC 53653] gi|302458961|gb|EFL22054.1| squalene synthase HpnD [Streptomyces himastatinicus ATCC 53653] Length=316 Score = 229 bits (584), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 138/286 (49%), Positives = 168/286 (59%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AYR E++T ARNF YGI+LLP EKR A+SA+YA RRIDD+ DG L + K L+ Sbjct 18 AYRYCEAVTGHQARNFAYGIKLLPTEKRHAMSALYAFSRRIDDIGDGALPADAKRARLNQ 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R LD I +D +DPV VAL AARRFP+P+ ELIDG ++ +D+ Sbjct 78 TRALLDRIRGGAIEEDDTDPVAVALTHAARRFPIPLGGLDELIDGVLKDVAGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFLNGR 175 L YCR AG IG+L L +FG V A YA LG+ALQ TNILRDVRED GR Sbjct 138 LKDYCRCVAGAIGRLSLGVFGTVPGARDASRAPEYANTLGLALQLTNILRDVREDAATGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G + A D D L L++F RA ++ G RL+P LDRRS Sbjct 198 AYLPADDLAKFGCTTAFHSSVAPADAD--LTGLVQFEVRRARALFAEGYRLLPMLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I PA V R+SL G +KA VA LA Sbjct 256 ACVAAMAGIYRRLLERIAHDPAAVLRGRVSLPGHEKAYVAVRGLAG 301 >gi|302537964|ref|ZP_07290306.1| squalene synthase HpnD [Streptomyces sp. C] gi|302446859|gb|EFL18675.1| squalene synthase HpnD [Streptomyces sp. C] Length=316 Score = 228 bits (581), Expect = 9e-58, Method: Compositional matrix adjust. Identities = 135/287 (48%), Positives = 170/287 (60%), Gaps = 10/287 (3%) Query 3 EIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKIT 62 ++ AY E++T T ARNF YGIRLLP +KR A+SA+YA RR+DD+ DG LAP+ K+ Sbjct 17 QVLAAYSYCEAVTGTQARNFAYGIRLLPTDKRQAMSALYAFSRRVDDIGDGALAPDAKLA 76 Query 63 ELDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCR 116 L+ R L I +D +DPV VALA AARRFP+P+ ELIDG M++ Sbjct 77 RLEDTRALLGRIRAGEVDEDDTDPVAVALAHAARRFPIPLGGLDELIDGVLMDVRGEEYE 136 Query 117 DFDELIVYCRRGAGTIGKLCLSIFGPVSTA--TSRYAEQLGIALQQTNILRDVREDFLNG 174 +D+L YCR AG IG+L L +FG V A YA+ LG+ALQ TNILRDVRED NG Sbjct 137 TWDDLKAYCRCVAGAIGRLSLGVFGTVGPADRADEYADTLGLALQLTNILRDVREDAGNG 196 Query 175 RIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRS 234 R YLP ++L + G A D A L+ RA ++ G RL+P LDRRS Sbjct 197 RTYLPAEDLAKFGCGEGFQGGRAPAGSD--FAGLVHHEVRRARALFTEGYRLLPMLDRRS 254 Query 235 AACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL +KA VA L+ Sbjct 255 GACVAAMAGIYRRLLDRIEREPEAVLRGRVSLPTHEKAYVAVRGLSG 301 >gi|254385934|ref|ZP_05001252.1| squalene/phytoene synthase [Streptomyces sp. Mg1] gi|194344797|gb|EDX25763.1| squalene/phytoene synthase [Streptomyces sp. Mg1] Length=311 Score = 228 bits (580), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 136/292 (47%), Positives = 170/292 (59%), Gaps = 17/292 (5%) Query 4 IEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITE 63 I AY E++T ARNF YGIRLLP +KR A+SA+YA RR+DD+ DG LAPE K+T Sbjct 6 ISAAYSYCEAVTGAQARNFAYGIRLLPTDKRHAMSALYAFSRRVDDIGDGTLAPEAKLTR 65 Query 64 LDAIRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRD 117 L+ R L I +D +DPV VALA AARRFP+P+ ELIDG M++ Sbjct 66 LEETRALLGRIRAEDVDEDDTDPVAVALAHAARRFPIPLEGLDELIDGVLMDVRGETYET 125 Query 118 FDELIVYCRRGAGTIGKLCLSIFGPVSTAT---------SRYAEQLGIALQQTNILRDVR 168 +D+L YCR AG IG+L L +FG V++ + YA+ LG+ALQ TNILRDVR Sbjct 126 WDDLKEYCRCVAGAIGRLSLGVFGTVNSGSLAPADAARADEYADTLGLALQLTNILRDVR 185 Query 169 EDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIP 228 ED NGR YLP ++L + G A D A L+ RA + G RL+P Sbjct 186 EDAANGRTYLPAEDLAKFGCSEGFHSDRAPAGAD--FAGLVHHEVRRARALFVEGYRLLP 243 Query 229 HLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALA 280 LDRRS AC AAM+GIYRR L I P V R+SL +KA VA L+ Sbjct 244 MLDRRSGACVAAMAGIYRRLLDRIEREPEAVLRGRVSLPTHEKAYVAVRGLS 295 >gi|329937104|ref|ZP_08286733.1| squalene/phytoene synthase [Streptomyces griseoaurantiacus M045] gi|329303711|gb|EGG47596.1| squalene/phytoene synthase [Streptomyces griseoaurantiacus M045] Length=316 Score = 226 bits (576), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 134/286 (47%), Positives = 168/286 (59%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AYR E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG+LA + K L+ Sbjct 18 AYRYCETVTGQQARNFAYGIRLLPTPKRRAMSALYAFSRRVDDIGDGDLADDVKKARLEE 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L + +D +DPV VALA AA RFP+P+ EL+DG M++ +D+ Sbjct 78 TRALLTRVRAGEVGEDDTDPVAVALAHAADRFPIPLGGLDELLDGVLMDVAGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFG-----PVSTATSRYAEQLGIALQQTNILRDVREDFLNGR 175 L YCR AG IG+L L +FG P + S YA+ LG+ALQ TNILRDVRED GR Sbjct 138 LKAYCRCVAGAIGRLSLGVFGTEPEAPGADRASEYADTLGLALQLTNILRDVREDAETGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G TG L A L+ F RA ++ G RL+P LDRRS Sbjct 198 TYLPADDLAKFGCSGGF--TGPLPPEGSDFAGLVHFEVRRARALFAEGYRLLPLLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 256 ACVAAMAGIYRRLLDRIEREPEAVLRGRVSLPGHEKAYVAVRGLSG 301 >gi|29828195|ref|NP_822829.1| squalene/phytoene synthase [Streptomyces avermitilis MA-4680] gi|29605297|dbj|BAC69364.1| squalene/phytoene synthase [Streptomyces avermitilis MA-4680] Length=316 Score = 225 bits (574), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 134/286 (47%), Positives = 167/286 (59%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF YGIRLLP KR A+SAVYA RR+DD+ DG LAP+ K L+ Sbjct 18 AYSYCETVTGQQARNFAYGIRLLPTPKRRAMSAVYAFSRRVDDIGDGALAPDVKAARLED 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L + +D +DPV VALA AA +FP+P+ ELIDG M++ +D+ Sbjct 78 TRALLSRVRDGRVDEDDTDPVAVALAHAAEQFPIPLGGLDELIDGVLMDVRGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFLNGR 175 L VYCR AG IG++ L +FG A S YA+ LG+ALQ TNILRDVRED GR Sbjct 138 LKVYCRCVAGAIGRVSLGVFGTEPGARGAERASEYADTLGLALQLTNILRDVREDAEGGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G D + D A L+ F RA ++ G RL+P LDRRS Sbjct 198 TYLPADDLAKFGCSAGFDRPIPPEGSD--FAGLVHFEVRRARALFAEGYRLLPMLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 256 ACVAAMAGIYRRLLDRIEREPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|297155998|gb|ADI05710.1| probable phytoene synthase [Streptomyces bingchenggensis BCW-1] Length=306 Score = 221 bits (564), Expect = 8e-56, Method: Compositional matrix adjust. Identities = 131/284 (47%), Positives = 165/284 (59%), Gaps = 17/284 (5%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AYR E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DG L + K L Sbjct 4 AYRYCEAVTGQQARNFAYGIRLLPTEKRRAMSALYAFSRRVDDIGDGRLDADAKRARLAD 63 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R LD I +D +DPV VALA AARRFP+P+ ELIDG M++ +D+ Sbjct 64 TRAVLDRIRDRGIEEDDTDPVAVALAHAARRFPIPLGGLDELIDGVLMDVSGQTYETWDD 123 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTA---------TSRYAEQLGIALQQTNILRDVREDF 171 L YCR AG IG+L L +FG V YA+ LG+ALQ TNILRD+RED Sbjct 124 LRAYCRCVAGAIGRLSLGVFGTVRAPGMSAREIERAPEYADTLGLALQLTNILRDIREDA 183 Query 172 LNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLD 231 GR YLP D+L + G + ++ PD L++F RA ++ G +L+P LD Sbjct 184 SGGRTYLPADDLAKFGCPTGIH--ASIAPPDADFTGLVQFEVRRARALFAEGYKLLPMLD 241 Query 232 RRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVA 275 RRS AC AAM+GIYRR L I P V R+SL G +K VA Sbjct 242 RRSGACVAAMAGIYRRLLERIARDPEAVLRGRVSLPGREKVYVA 285 >gi|297203850|ref|ZP_06921247.1| squalene synthase HpnD [Streptomyces sviceus ATCC 29083] gi|297148512|gb|EDY55938.2| squalene synthase HpnD [Streptomyces sviceus ATCC 29083] Length=316 Score = 221 bits (562), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 133/286 (47%), Positives = 168/286 (59%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG LA + K L+ Sbjct 18 AYSYCEAVTGQQARNFAYGIRLLPTSKRRAMSALYAFSRRVDDIGDGALAGDVKAARLED 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L + +D +DPV VALA AA FP+P++ ELIDG M++ +D+ Sbjct 78 TRAMLTRVREGSVAEDDTDPVAVALAHAAETFPIPLSGLDELIDGVLMDVRGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFLNGR 175 L VYCR AG IG+L L +FG P + A R YA+ LG+ALQ TNILRDVRED +GR Sbjct 138 LKVYCRCVAGAIGRLSLGVFGTEPGARAAERAPEYADTLGLALQLTNILRDVREDAEDGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G + D A L+ F RA ++ G RL+P LDRRS Sbjct 198 TYLPADDLAKFGCSAGFKGPKPPEGAD--FAGLVHFEVRRARALFAEGYRLLPMLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 256 ACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|302557116|ref|ZP_07309458.1| squalene synthase HpnD [Streptomyces griseoflavus Tu4000] gi|302474734|gb|EFL37827.1| squalene synthase HpnD [Streptomyces griseoflavus Tu4000] Length=316 Score = 220 bits (561), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 132/287 (46%), Positives = 166/287 (58%), Gaps = 15/287 (5%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG LA + K+T L+ Sbjct 18 AYSYCEAVTGQQARNFAYGIRLLPTPKRRAMSALYAFSRRVDDIGDGPLADDVKVTRLED 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L I +D +DPV VALA AA FP+P+ ELIDG +M++ +D+ Sbjct 78 TRALLTRIREGAVDEDDTDPVAVALAHAAGHFPIPLGGLDELIDGVQMDVRGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFLNGR 175 L YCR AG IG+L L +FG A S YA+ LG+ALQ TNILRDVRED GR Sbjct 138 LKAYCRCVAGAIGRLSLGVFGTEPGARGAERASEYADTLGLALQLTNILRDVREDAAGGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLDRRS 234 YLP D+L + G P+G L+ + RA ++ G RL+P LDRRS Sbjct 198 TYLPADDLAKFGCSAGF---AGPTPPEGSDFTGLVHYEVRRARALFAEGYRLLPLLDRRS 254 Query 235 AACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 255 GACVAAMAGIYRRLLDRIERDPGAVLRGRVSLPGHEKAYVAVRGLSG 301 >gi|290955845|ref|YP_003487027.1| squalene/phytoene synthase [Streptomyces scabiei 87.22] gi|260645371|emb|CBG68457.1| putative squalene/phytoene synthase [Streptomyces scabiei 87.22] Length=316 Score = 218 bits (555), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 132/286 (47%), Positives = 165/286 (58%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG LA E K L+ Sbjct 18 AYSYCEAVTGQQARNFAYGIRLLPTPKRRAMSALYAFSRRVDDIGDGALAVEVKTARLEE 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L + +D +DPV VAL A FP+P+ ELIDG ++ +D+ Sbjct 78 SRTLLTRVRGGSVDEDDTDPVAVALTHAQSAFPIPLDALDELIDGVLKDVRGEYYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFLNGR 175 L VYCR AG+IG+L L +FG P + + R YA+ LG+ALQ TNILRDVRED GR Sbjct 138 LKVYCRCVAGSIGRLSLGVFGTEPGARGSERAPEYADTLGLALQLTNILRDVREDAEGGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G G L D A L+ F RA ++ G RL+P LDRRS Sbjct 198 TYLPTDDLAKFGCSAGF--AGPLPPADSDFAGLVHFEVRRARALFAEGYRLLPMLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 256 ACVAAMAGIYRRLLDRIEREPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|294632399|ref|ZP_06710959.1| squalene synthase HpnD [Streptomyces sp. e14] gi|292835732|gb|EFF94081.1| squalene synthase HpnD [Streptomyces sp. e14] Length=316 Score = 217 bits (553), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 133/286 (47%), Positives = 165/286 (58%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG LA + K L Sbjct 18 AYSYCEAVTGQQARNFAYGIRLLPTPKRRAMSALYAFSRRVDDIGDGALADDVKAARLKD 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R LD I DD +DPV VALA AAR FP+P+ ELIDG ++ +D+ Sbjct 78 TRALLDRIRDGAVEDDDTDPVAVALAHAARSFPIPLDGLDELIDGVLADVRGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFLNGR 175 L VYCR AG IG+L L +FG P + R YA+ LG+ALQ TNILRD+RED GR Sbjct 138 LKVYCRCVAGAIGRLSLGVFGTEPGARGAERAPEYADTLGLALQLTNILRDIREDAEGGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G G + A L+ F RA ++ G +L+P LDRRS Sbjct 198 TYLPADDLAKFGCSAGFH--GPIPPEGSDFAGLIHFEVRRARALFAEGYQLLPMLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 256 ACVAAMAGIYRRLLDRIARDPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|345010489|ref|YP_004812843.1| squalene synthase HpnD [Streptomyces violaceusniger Tu 4113] gi|344036838|gb|AEM82563.1| squalene synthase HpnD [Streptomyces violaceusniger Tu 4113] Length=316 Score = 215 bits (548), Expect = 6e-54, Method: Compositional matrix adjust. Identities = 137/290 (48%), Positives = 168/290 (58%), Gaps = 17/290 (5%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AYR E++T ARNF YGIRLLP EKR A+SA+YA RR+DD+ DG L PE K L Sbjct 14 AYRYCEAVTGHQARNFAYGIRLLPTEKRHAMSALYAFSRRVDDIGDGPLDPEAKRARLTD 73 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R LD + +D +DPV VA+A AA RFP+P+ ELIDG M++ +D+ Sbjct 74 TRALLDRMRGGGIEEDDTDPVAVAVAHAAHRFPIPLDALDELIDGVLMDVAGQTYETWDD 133 Query 121 LIVYCRRGAGTIGKLCLSIFGPV-STATSR--------YAEQLGIALQQTNILRDVREDF 171 L VYCR AG IG+L L +FG T S YA+ LG+ALQ TNILRDVRED Sbjct 134 LKVYCRCVAGAIGRLSLGVFGTAPGTGHSEDELERAPYYADTLGLALQLTNILRDVREDA 193 Query 172 LNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLD 231 GR YLP D+L + G G+ PD L+ F RA ++ G RL+P LD Sbjct 194 ATGRTYLPADDLAKFGCADAF--RGSTAPPDADFTGLVHFEVRRARALFAEGFRLLPLLD 251 Query 232 RRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 RRS AC +AM+GIY R L I PA V R+SL G +KA VA LA Sbjct 252 RRSGACVSAMAGIYSRLLDRIAKDPAAVLRGRVSLPGHEKAYVAVRGLAG 301 >gi|302555530|ref|ZP_07307872.1| squalene synthase HpnD [Streptomyces viridochromogenes DSM 40736] gi|302473148|gb|EFL36241.1| squalene synthase HpnD [Streptomyces viridochromogenes DSM 40736] Length=316 Score = 214 bits (546), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 131/286 (46%), Positives = 166/286 (59%), Gaps = 13/286 (4%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AY E++T ARNF YGIRLLP +R A+SA+YA RR+DD+ DG LA + K+ L+ Sbjct 18 AYSYCEAVTGRQARNFAYGIRLLPAPQRRAMSALYAFSRRVDDIGDGALAGDVKVARLEE 77 Query 67 IRKSLD------NIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L +D +DPV VAL AAR FP+P+ ELIDG M++ +D+ Sbjct 78 TRALLTRIREDEIDEDDTDPVAVALTHAARHFPIPLGGLDELIDGVLMDVRGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFG--PVSTATSR---YAEQLGIALQQTNILRDVREDFLNGR 175 L VYCR AG IG+L L +FG P + R YA+ LG+ALQ TNILRDVRED + GR Sbjct 138 LKVYCRCVAGAIGRLSLGVFGTEPGARGVDRAPEYADTLGLALQLTNILRDVREDAVGGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSA 235 YLP D+L + G + D A L+ F RA ++ G RL+P LDRRS Sbjct 198 TYLPADDLAKFGCSAGFSGPRPPEGSD--FAGLVHFEVRRARALFAEGYRLLPMLDRRSG 255 Query 236 ACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 256 ACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREKAYVAVRGLSG 301 >gi|291435807|ref|ZP_06575197.1| phytoene synthase [Streptomyces ghanaensis ATCC 14672] gi|291338702|gb|EFE65658.1| phytoene synthase [Streptomyces ghanaensis ATCC 14672] Length=312 Score = 209 bits (533), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 135/287 (48%), Positives = 166/287 (58%), Gaps = 15/287 (5%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AYR E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG LA + K L+ Sbjct 14 AYRYCEAVTGHQARNFAYGIRLLPTPKRRAMSALYAFSRRVDDIGDGALADDVKTARLED 73 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L I +D +DPV VALA AA FP+P+ ELIDG RM++ +D+ Sbjct 74 TRALLARIRDGAVDEDDTDPVAVALAHAAAHFPIPLGGLDELIDGVRMDVRGETYETWDD 133 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTA-----TSRYAEQLGIALQQTNILRDVREDFLNGR 175 L YCR AG IG+L L +FG A YA+ LG+ALQ TNILRDVRED GR Sbjct 134 LKAYCRCVAGAIGRLSLGVFGTERGARGAERAPEYADTLGLALQLTNILRDVREDAEGGR 193 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLDRRS 234 YLP D+L + G G P+G A L+ F RA ++ G RL+P LDRRS Sbjct 194 TYLPADDLAKFGCSAGF---GGPTPPEGSDFAGLMHFEVRRARALFAEGYRLLPLLDRRS 250 Query 235 AACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS 281 AC AAM+GIYRR L I P V R+SL G +KA VA L+ Sbjct 251 GACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSG 297 >gi|337768915|emb|CCB77628.1| putative phytoene synthase [Streptomyces cattleya NRRL 8057] Length=313 Score = 209 bits (533), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 137/285 (49%), Positives = 169/285 (60%), Gaps = 15/285 (5%) Query 7 AYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDA 66 AYR E++T ARNF YGIRLLP KR A+SA+YA RR+DD+ DG+L P K L Sbjct 18 AYRYCETVTGQQARNFAYGIRLLPTGKRQAMSALYAFSRRVDDIGDGDLDPAAKRDRLTR 77 Query 67 IRKSLDNI------DDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE 120 R L + DD +DPV +ALADAARRFP+P+ ELIDG M++ +D+ Sbjct 78 TRDVLARVRAGEVGDDDTDPVALALADAARRFPLPLDGLDELIDGVLMDVRGETYETWDD 137 Query 121 LIVYCRRGAGTIGKLCLSIFGPVSTAT-----SRYAEQLGIALQQTNILRDVREDFLNGR 175 L YCR AG IG+L L +FG V A + YA+ LG+ALQ TNILRDVRED NGR Sbjct 138 LKDYCRCVAGAIGRLSLGVFGTVPGAVGTERAAEYADTLGLALQLTNILRDVREDAGNGR 197 Query 176 IYLPRDELDRLGVRLRLDDTGALDDPDGR-LAALLRFSADRAADWYSLGLRLIPHLDRRS 234 YLP ++L + G G+ P G L+ F RA ++ G RL+P LDRRS Sbjct 198 TYLPAEDLAKFGCSAGF---GSPVPPAGSDFTGLVHFEVKRARALFAEGYRLLPMLDRRS 254 Query 235 AACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAAL 279 AC AAM+GIYRR L I A P V R+SL G +KA VA L Sbjct 255 GACVAAMAGIYRRLLERIAADPEAVLRGRVSLPGHEKAYVALRGL 299 >gi|254447234|ref|ZP_05060701.1| phytoene synthase [gamma proteobacterium HTCC5015] gi|198263373|gb|EDY87651.1| phytoene synthase [gamma proteobacterium HTCC5015] Length=298 Score = 167 bits (423), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 100/269 (38%), Positives = 145/269 (54%), Gaps = 11/269 (4%) Query 15 TRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDAIRKSLDNI 74 T+++ +FY+ R LP E+R + A+YA R +DDV D L + +ELD R+ +D++ Sbjct 18 TKSSGSSFYHSFRFLPEEQRLGMIALYAFCREVDDVVDETLDEQQARSELDEWRQRVDDL 77 Query 75 DD--SSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTI 132 + + PV +AL D +RF + ELIDG M++D +F EL +YC R A + Sbjct 78 YNGRADHPVCIALKDDLQRFNLHREHLLELIDGMAMDLDQNEYANFSELALYCYRAASVV 137 Query 133 GKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPRDELDRLGV---R 189 G L + IFG T +YA LG+A Q TNILRDV ED GRIYLP+DEL R GV Sbjct 138 GLLTVEIFGYRDRGTLQYAHDLGMAFQLTNILRDVGEDAKRGRIYLPQDELQRFGVAKAH 197 Query 190 LRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAMSGIYRRQL 249 L L+ T P+ + L + A+RA +Y +P DR + M+ +Y R L Sbjct 198 LHLNHTT----PEAQ--KLFAYQAERAERYYQKAFATLPEGDRYAQRSGLIMAAVYHRLL 251 Query 250 ALIRASPAVVYDRRISLSGLKKAQVAAAA 278 I + ++R SLS +K ++A A Sbjct 252 QHIGQRDFRILEQRPSLSKWRKIRIAWTA 280 >gi|220934696|ref|YP_002513595.1| terpenoid synthase [Thioalkalivibrio sulfidophilus HL-EbGr7] gi|219996006|gb|ACL72608.1| putative terpenoid synthase [Thioalkalivibrio sulfidophilus HL-EbGr7] Length=293 Score = 165 bits (418), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 96/257 (38%), Positives = 138/257 (54%), Gaps = 5/257 (1%) Query 21 NFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDAIRKSLDNI--DDSS 78 +FYY LP ++R A++A+YA R +DDV D P+ +LD R+ + + + + Sbjct 17 SFYYSFLFLPEQQRRAITALYAFCREVDDVVDECQEPDIARRKLDWWREEIARVFAGNPN 76 Query 79 DPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLS 138 PV AL A R+ +P F E+IDG +M++D+ F EL +YC R A +G + Sbjct 77 HPVGKALLPAIERYNLPEEHFREIIDGMQMDLDYDAYPTFTELSLYCYRVASVVGLMAAE 136 Query 139 IFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGAL 198 IFG T+RYA LG+A Q TNILRDV ED L GR+Y+P DE+ R GV R + Sbjct 137 IFGYQDRQTTRYAHDLGMAFQLTNILRDVHEDALRGRVYIPMDEMRRFGVEPR---ELQM 193 Query 199 DDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAV 258 L +L F A RA D+Y +P +DR + M+ IY+ L I A Sbjct 194 PQASEHLKSLFEFQARRARDYYKRAFERLPEVDRPAQRSGIIMAAIYQTLLDEIEADGYR 253 Query 259 VYDRRISLSGLKKAQVA 275 V +RRI L+ ++K +A Sbjct 254 VLERRIRLTPIRKLWIA 270 >gi|258592263|emb|CBE68572.1| Squalene/phytoene synthase [NC10 bacterium 'Dutch sediment'] Length=285 Score = 163 bits (412), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 107/281 (39%), Positives = 146/281 (52%), Gaps = 9/281 (3%) Query 1 MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETK 60 M +++ + + +IT+ + NFYY LP+ KR AL AVYA R DD+ D A Sbjct 1 MNQVDDFHANSRTITKQSRSNFYYAFLFLPKPKREALYAVYAFCRLSDDLVDESKAGVNP 60 Query 61 ITELDAIRKSLD-NIDDSSD-PVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCR-- 116 L RK+LD +DD D PV+ A+ AAR+F +P F EL++G ME+D T R Sbjct 61 ADALTRWRKTLDVCLDDGVDSPVMTAVGQAARQFHIPKVYFEELLNG--MEMDLTRARYA 118 Query 117 DFDELIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRI 176 F++L YC R A +G +C+ IFG + T RYAEQLGIA Q TNILRDV D GRI Sbjct 119 TFEDLYPYCYRVASIVGLICIEIFGYTNPLTKRYAEQLGIAFQLTNILRDVGVDAQRGRI 178 Query 177 YLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAA 236 YLP+DEL R G ++ + L+RF +RA ++ + D RS Sbjct 179 YLPQDELQRFGYS---EEELLAGRYNYAFTELMRFQCERARGYFRTASAALTAEDERSLL 235 Query 237 CCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAA 277 M IY R L I A V+ I++ +K +A Sbjct 236 AAEIMRAIYYRVLLRIEAQHYDVFRGDITIGKSQKLLLAGG 276 >gi|335042066|ref|ZP_08535093.1| phytoene/squalene synthetase [Methylophaga aminisulfidivorans MP] gi|333788680|gb|EGL54562.1| phytoene/squalene synthetase [Methylophaga aminisulfidivorans MP] Length=281 Score = 159 bits (401), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 99/257 (39%), Positives = 133/257 (52%), Gaps = 5/257 (1%) Query 21 NFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDAIRKSLDNI--DDSS 78 +FYY LP +KR A++A+YA R +DD D P+ L R ++NI ++ Sbjct 17 SFYYSFMFLPPQKRQAITALYAFCREVDDAVDEIADPQVAAQTLSWWRSEVENIFNQTAT 76 Query 79 DPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLS 138 PV AL +A + F + F E+IDG M++ F L +YC R A +G L Sbjct 77 HPVGKALEEAIKHFELHQEYFLEIIDGMEMDLFQHRYDAFKHLALYCHRVASVVGLLAAE 136 Query 139 IFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGAL 198 IFG + T +YAE+LG+A Q TNI+RDVRED GRIYLP +++ R V +D AL Sbjct 137 IFGYQNRQTLKYAEKLGLAFQLTNIIRDVREDAERGRIYLPAEDMARFKV--SEEDILAL 194 Query 199 DDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAV 258 L ALL F +RA +Y L+P DR S MS IY L I Sbjct 195 KQT-AELTALLAFETERARSFYQEAKTLLPKEDRYSQRTGLIMSAIYEATLDEIEKDQFQ 253 Query 259 VYDRRISLSGLKKAQVA 275 V +RISL+ LKK +A Sbjct 254 VMKQRISLTPLKKLWLA 270 >gi|91775822|ref|YP_545578.1| squalene/phytoene synthase [Methylobacillus flagellatus KT] gi|91709809|gb|ABE49737.1| Squalene/phytoene synthase [Methylobacillus flagellatus KT] Length=278 Score = 154 bits (389), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 97/258 (38%), Positives = 137/258 (54%), Gaps = 6/258 (2%) Query 21 NFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDAIRKSLDNIDDS--S 78 +FYY LP+ KR A++A+YA R +DD+AD T+L+ R + N+ + Sbjct 17 SFYYSFLFLPKAKREAITALYAFCREVDDIADDVQDVNVAQTKLNWWRSEIINLFEGKPQ 76 Query 79 DPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLS 138 PV +AL R + F E+I+G +M+++ RDF+EL +YC R A +G L S Sbjct 77 HPVTMALQSPVRELKLKQQHFLEIINGMQMDLEQNRYRDFEELELYCYRVASVVGLLSAS 136 Query 139 IFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGAL 198 IFG + T +YA LG+A Q TNI RDV ED GRIYLP DE+ R GV + G Sbjct 137 IFGYSNPQTLQYALDLGMAFQLTNITRDVGEDGRRGRIYLPLDEISRFGVSEQDILQGKA 196 Query 199 DDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALI-RASPA 257 D + LL F +RA +Y L +P DR+ M+ IYR L I R Sbjct 197 SD---NMRQLLEFQVERAERYYEKALAELPLEDRKQQRTGLIMASIYRTLLKEIKRDDIQ 253 Query 258 VVYDRRISLSGLKKAQVA 275 VV + R+SL+ ++K +A Sbjct 254 VVLNARVSLTPIRKLWLA 271 Lambda K H 0.323 0.138 0.406 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 505781532318 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40