BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3606c Length=188 Score E Sequences producing significant alignments: (Bits) Value gi|15610742|ref|NP_218123.1| 2-amino-4-hydroxy-6-hydroxymethyldi... 376 7e-103 gi|121639525|ref|YP_979749.1| 2-amino-4-hydroxy-6-hydroxymethyld... 375 2e-102 gi|148824811|ref|YP_001289565.1| 2-amino-4-hydroxy-6-hydroxymeth... 374 5e-102 gi|254552720|ref|ZP_05143167.1| 2-amino-4-hydroxy-6-hydroxymethy... 368 3e-100 gi|296166672|ref|ZP_06849097.1| 2-amino-4-hydroxy-6-hydroxymethy... 249 9e-65 gi|41406550|ref|NP_959386.1| hypothetical protein MAP0452 [Mycob... 246 9e-64 gi|254822685|ref|ZP_05227686.1| 2-amino-4-hydroxy-6-hydroxymethy... 246 1e-63 gi|118464375|ref|YP_879826.1| 2-amino-4-hydroxy-6-hydroxymethyld... 245 3e-63 gi|336458522|gb|EGO37493.1| 2-amino-4-hydroxy-6-hydroxymethyldih... 244 4e-63 gi|342862043|ref|ZP_08718687.1| hypothetical protein MCOL_24250 ... 241 5e-62 gi|15827023|ref|NP_301286.1| 2-amino-4-hydroxy-6-hydroxymethyldi... 232 2e-59 gi|183985077|ref|YP_001853368.1| 2-amino-4-hydroxy-6- hydroxymet... 218 4e-55 gi|118619362|ref|YP_907694.1| 2-amino-4-hydroxy-6- hydroxymethyl... 216 2e-54 gi|240172849|ref|ZP_04751508.1| 2-amino-4-hydroxy-6- hydroxymeth... 213 9e-54 gi|118472499|ref|YP_890322.1| 2-amino-4-hydroxy-6-hydroxymethyld... 211 5e-53 gi|126437716|ref|YP_001073407.1| 2-amino-4-hydroxy-6-hydroxymeth... 207 5e-52 gi|333992535|ref|YP_004525149.1| 2-amino-4-hydroxy-6- hydroxymet... 206 1e-51 gi|108801729|ref|YP_641926.1| 2-amino-4-hydroxy-6-hydroxymethyld... 204 6e-51 gi|120406316|ref|YP_956145.1| 2-amino-4-hydroxy-6-hydroxymethyld... 192 2e-47 gi|226304118|ref|YP_002764076.1| 2-amino-4-hydroxy-6- hydroxymet... 182 1e-44 gi|325675043|ref|ZP_08154730.1| 2-amino-4-hydroxy-6-hydroxymethy... 170 1e-40 gi|169627641|ref|YP_001701290.1| 2-amino-4-hydroxy-6-hydroxymeth... 169 2e-40 gi|54022366|ref|YP_116608.1| putative 2-amino-4-hydroxy-6- hydro... 169 3e-40 gi|312138056|ref|YP_004005392.1| 2-amino-4-hydroxy-6-hydroxymeth... 166 1e-39 gi|145222012|ref|YP_001132690.1| 2-amino-4-hydroxy-6-hydroxymeth... 165 3e-39 gi|315446248|ref|YP_004079127.1| 2-amino-4-hydroxy-6-hydroxymeth... 163 1e-38 gi|331699839|ref|YP_004336078.1| 2-amino-4-hydroxy-6-hydroxymeth... 160 7e-38 gi|226363737|ref|YP_002781519.1| 2-amino-4-hydroxy-6- hydroxymet... 159 2e-37 gi|343924374|ref|ZP_08763924.1| 2-amino-4-hydroxy-6-hydroxymethy... 159 2e-37 gi|111021383|ref|YP_704355.1| 2-amino-4-hydroxy-6-hydroxymethyld... 155 2e-36 gi|296392858|ref|YP_003657742.1| 2-amino-4-hydroxy-6-hydroxymeth... 152 3e-35 gi|296138299|ref|YP_003645542.1| 2-amino-4-hydroxy-6-hydroxymeth... 149 2e-34 gi|262203868|ref|YP_003275076.1| 2-amino-4-hydroxy-6-hydroxymeth... 147 9e-34 gi|325000123|ref|ZP_08121235.1| 2-amino-4-hydroxy-6-hydroxymethy... 140 9e-32 gi|271970336|ref|YP_003344532.1| 2-amino-4-hydroxy-6-hydroxymeth... 139 2e-31 gi|255325840|ref|ZP_05366932.1| 2-amino-4-hydroxy-6-hydroxymethy... 137 1e-30 gi|311740147|ref|ZP_07713979.1| 2-amino-4-hydroxy-6-hydroxymethy... 136 2e-30 gi|305680505|ref|ZP_07403313.1| 2-amino-4-hydroxy-6-hydroxymethy... 135 4e-30 gi|317507807|ref|ZP_07965508.1| 7,8-dihydro-6-hydroxymethylpteri... 135 4e-30 gi|225022116|ref|ZP_03711308.1| hypothetical protein CORMATOL_02... 135 4e-30 gi|227547911|ref|ZP_03977960.1| 2-amino-4-hydroxy-6-hydroxymethy... 134 5e-30 gi|227834062|ref|YP_002835769.1| 2-amino-4-hydroxy-6- hydroxymet... 133 2e-29 gi|296118969|ref|ZP_06837542.1| 2-amino-4-hydroxy-6-hydroxymethy... 132 2e-29 gi|284989217|ref|YP_003407771.1| 2-amino-4-hydroxy-6-hydroxymeth... 132 3e-29 gi|38234561|ref|NP_940328.1| putative 7,8-dihydro-6-hydroxymethy... 130 9e-29 gi|213965103|ref|ZP_03393301.1| 2-amino-4-hydroxy-6-hydroxymethy... 130 1e-28 gi|256374472|ref|YP_003098132.1| 2-amino-4-hydroxy-6-hydroxymeth... 129 3e-28 gi|306836923|ref|ZP_07469876.1| 2-amino-4-hydroxy-6-hydroxymethy... 128 3e-28 gi|227505945|ref|ZP_03935994.1| 2-amino-4-hydroxy-6-hydroxymethy... 128 3e-28 gi|258651096|ref|YP_003200252.1| 2-amino-4-hydroxy-6-hydroxymeth... 127 1e-27 >gi|15610742|ref|NP_218123.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase FolK [Mycobacterium tuberculosis H37Rv] gi|15843218|ref|NP_338255.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium tuberculosis CDC1551] gi|31794782|ref|NP_857275.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase FolK [Mycobacterium bovis AF2122/97] 70 more sequence titles Length=188 Score = 376 bits (966), Expect = 7e-103, Method: Compositional matrix adjust. Identities = 188/188 (100%), Positives = 188/188 (100%), Gaps = 0/188 (0%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP Sbjct 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP Sbjct 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH 180 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH Sbjct 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH 180 Query 181 PVSRAPES 188 PVSRAPES Sbjct 181 PVSRAPES 188 >gi|121639525|ref|YP_979749.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224992022|ref|YP_002646711.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium bovis BCG str. Tokyo 172] gi|121495173|emb|CAL73659.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase folK [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224775137|dbj|BAH27943.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium bovis BCG str. Tokyo 172] gi|341603546|emb|CCC66227.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase folK [Mycobacterium bovis BCG str. Moreau RDJ] Length=188 Score = 375 bits (963), Expect = 2e-102, Method: Compositional matrix adjust. Identities = 187/188 (99%), Positives = 188/188 (100%), Gaps = 0/188 (0%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP Sbjct 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 TCEPREWLRRA+EFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP Sbjct 61 TCEPREWLRRAEEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH 180 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH Sbjct 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH 180 Query 181 PVSRAPES 188 PVSRAPES Sbjct 181 PVSRAPES 188 >gi|148824811|ref|YP_001289565.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK [Mycobacterium tuberculosis F11] gi|148723338|gb|ABR07963.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK [Mycobacterium tuberculosis F11] Length=188 Score = 374 bits (959), Expect = 5e-102, Method: Compositional matrix adjust. Identities = 187/188 (99%), Positives = 187/188 (99%), Gaps = 0/188 (0%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP Sbjct 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP Sbjct 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH 180 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFR SFDLNSRH Sbjct 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRLSFDLNSRH 180 Query 181 PVSRAPES 188 PVSRAPES Sbjct 181 PVSRAPES 188 >gi|254552720|ref|ZP_05143167.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|323717714|gb|EGB26914.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK [Mycobacterium tuberculosis CDC1551A] gi|339296423|gb|AEJ48534.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase FolK [Mycobacterium tuberculosis CCDC5079] Length=184 Score = 368 bits (944), Expect = 3e-100, Method: Compositional matrix adjust. Identities = 183/184 (99%), Positives = 184/184 (100%), Gaps = 0/184 (0%) Query 5 VLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEP 64 +LSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEP Sbjct 1 MLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEP 60 Query 65 REWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLA 124 REWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLA Sbjct 61 REWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLA 120 Query 125 HLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSR 184 HLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSR Sbjct 121 HLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSR 180 Query 185 APES 188 APES Sbjct 181 APES 184 >gi|296166672|ref|ZP_06849097.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295897937|gb|EFG77518.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=182 Score = 249 bits (637), Expect = 9e-65, Method: Compositional matrix adjust. Identities = 128/188 (69%), Positives = 147/188 (79%), Gaps = 6/188 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VVLSVGSNLGDRLARL+SV DGLG+ ++A SP+YE DPWG V+Q FLNAVLIA+DP Sbjct 1 MTWVVLSVGSNLGDRLARLQSVVDGLGEQVLAVSPVYETDPWGRVDQAPFLNAVLIANDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 C+ + WLRRAQEFERAAGRVRG+RWGPR LDVDLIACY + EV +REN+LTLP Sbjct 61 ACDGQCWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYDEA------EVISRENNLTLP 114 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH 180 HPLAHLRAFV+IPW+A+DP AQLTVA PRPV LLAELEPADR+ VRL + Sbjct 115 HPLAHLRAFVMIPWLAIDPDAQLTVAEGPRPVAGLLAELEPADREGVRLTDLTLHRAGGS 174 Query 181 PVSRAPES 188 P PE+ Sbjct 175 PADPEPET 182 >gi|41406550|ref|NP_959386.1| hypothetical protein MAP0452 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41394899|gb|AAS02769.1| FolK [Mycobacterium avium subsp. paratuberculosis K-10] Length=182 Score = 246 bits (629), Expect = 9e-64, Method: Compositional matrix adjust. Identities = 125/168 (75%), Positives = 139/168 (83%), Gaps = 6/168 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLS+GSNLGDRLARL+SV DGLG A+ A SP+YE PWG V+Q FLNAVLIADDP Sbjct 1 MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 C+ + WLRRAQEFERAAGRVRG+RWGPR LDVDLIACY EV +REN+LTLP Sbjct 61 ACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYGDG------EVISRENNLTLP 114 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HPLAHLRAFVLIPW+AVDP AQLTVA P+PV RLLA+L+ ADRD VR Sbjct 115 HPLAHLRAFVLIPWLAVDPDAQLTVADGPQPVARLLAQLDQADRDGVR 162 >gi|254822685|ref|ZP_05227686.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium intracellulare ATCC 13950] Length=169 Score = 246 bits (628), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 124/175 (71%), Positives = 144/175 (83%), Gaps = 6/175 (3%) Query 4 VVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCE 63 +VLS+GSNLGDRLARL+SV DGLGD ++A SP+YE DPWG V+Q FLNAVLIADDP C+ Sbjct 1 MVLSIGSNLGDRLARLQSVVDGLGDTVLAVSPVYETDPWGRVDQAPFLNAVLIADDPACD 60 Query 64 PREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPL 123 + WL RAQEFERAAGRVRG+RWGPR LDVDLIACY + EVT+REN+LTLPHPL Sbjct 61 GQGWLARAQEFERAAGRVRGERWGPRTLDVDLIACYGQA------EVTSRENNLTLPHPL 114 Query 124 AHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNS 178 AHLRAFVLIPW+AVDP A+LTVA PRPV +LLAELEPADR +VR + +L + Sbjct 115 AHLRAFVLIPWLAVDPDARLTVAEGPRPVAQLLAELEPADRAAVRRSDLTLELTT 169 >gi|118464375|ref|YP_879826.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium avium 104] gi|254773205|ref|ZP_05214721.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium avium subsp. avium ATCC 25291] gi|118165662|gb|ABK66559.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium avium 104] Length=182 Score = 245 bits (625), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 124/168 (74%), Positives = 139/168 (83%), Gaps = 6/168 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLS+GSNLGDRLARL+SV DGLG A+ A SP+YE PWG V+Q FLNAVLIADDP Sbjct 1 MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 C+ + WLRRAQEFERAAGRVRG+RWGPR LDVDLIACY EV +REN+LTLP Sbjct 61 ACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYGDG------EVISRENNLTLP 114 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HPLAHLRAFVLIPW+AVDP A+LTVA P+PV RLLA+L+ ADRD VR Sbjct 115 HPLAHLRAFVLIPWLAVDPDARLTVADGPQPVARLLAQLDQADRDGVR 162 >gi|336458522|gb|EGO37493.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium avium subsp. paratuberculosis S397] Length=182 Score = 244 bits (623), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 124/168 (74%), Positives = 139/168 (83%), Gaps = 6/168 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLS+GSNLGDRLARL+SV DGLG A+ A SP+YE PWG V+Q FLNAVLIADDP Sbjct 1 MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 C+ + WLRRAQEFERAAGRVRG+RWGPR LDVDLIACY EV +REN+LTLP Sbjct 61 ACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYGDG------EVISRENNLTLP 114 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HPLAHLRAFVLIPW+AVDP A+LTVA P+PV RLLA+L+ ADRD VR Sbjct 115 HPLAHLRAFVLIPWLAVDPDARLTVADGPQPVARLLAQLDQADRDGVR 162 >gi|342862043|ref|ZP_08718687.1| hypothetical protein MCOL_24250 [Mycobacterium colombiense CECT 3035] gi|342130583|gb|EGT83892.1| hypothetical protein MCOL_24250 [Mycobacterium colombiense CECT 3035] Length=182 Score = 241 bits (614), Expect = 5e-62, Method: Compositional matrix adjust. Identities = 120/168 (72%), Positives = 138/168 (83%), Gaps = 6/168 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLS+GSNLGDRLARL+SV DGLG+ ++A SP+YE DPWG V+Q FLNAVLIADDP Sbjct 1 MTRVVLSIGSNLGDRLARLQSVVDGLGEKVLAVSPVYETDPWGRVDQAPFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 C+ + WLRRAQEFERAAGRVRG+RWGPR LDVDLIACY + EV +REN+LTLP Sbjct 61 ACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYGAT------EVISRENNLTLP 114 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HPLAHLRAFVLIPW+ VDP A+LT+A +P LLA+LE ADRD VR Sbjct 115 HPLAHLRAFVLIPWLDVDPDARLTLADGSQPAAGLLAQLEAADRDGVR 162 >gi|15827023|ref|NP_301286.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase [Mycobacterium leprae TN] gi|221229501|ref|YP_002502917.1| putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase [Mycobacterium leprae Br4923] gi|6016247|sp|O69528.1|HPPK_MYCLE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Short=PPPK; AltName: Full=7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Short=HPPK gi|3097221|emb|CAA18792.1| 2-amino-4-hydroxy-6-hydroxymethyl dihydropteridine pyrophosphokinase [Mycobacterium leprae] gi|13092570|emb|CAC29734.1| putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase [Mycobacterium leprae] gi|219932608|emb|CAR70319.1| putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase [Mycobacterium leprae Br4923] Length=191 Score = 232 bits (592), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 118/182 (65%), Positives = 138/182 (76%), Gaps = 1/182 (0%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLS+GSNLGDRLA L+S DGLGDA++A SP+Y+ PWG VEQ FLNAV+IAD P Sbjct 1 MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSFLNAVVIADGP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTS-ATEALVEVTARENHLTL 119 + + WL RAQE ER AGRVRGQRWG R LDVDLI+CYQTS AT VEV E++LTL Sbjct 61 AYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQTSGATTGAVEVITCESNLTL 120 Query 120 PHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSR 179 PHP AHLRAFVL+PW+AVD A+LTVAG + V RLLAE+EP +R+ VRL + L Sbjct 121 PHPRAHLRAFVLVPWLAVDSDAELTVAGRAQRVDRLLAEMEPTEREGVRLTNLTLKLKRS 180 Query 180 HP 181 P Sbjct 181 SP 182 >gi|183985077|ref|YP_001853368.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK [Mycobacterium marinum M] gi|183178403|gb|ACC43513.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK [Mycobacterium marinum M] Length=175 Score = 218 bits (554), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 113/169 (67%), Positives = 126/169 (75%), Gaps = 1/169 (0%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+ VVLSVGSNLGDRLA LRSV DGLGD L+ AS +YE DPWGGV Q FLN VLIADDP Sbjct 1 MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPFLNVVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WL +AQEFERAAGR R QRWGPR LDVDL+ACYQ + EV ++ LTLP Sbjct 61 ARDGHAWLHQAQEFERAAGRQRLQRWGPRTLDVDLVACYQ-AGPAGRTEVRCNDSILTLP 119 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRL 169 HPLAH RAFV++PW+ VDP A+LT PRPV LLA L PADR SVRL Sbjct 120 HPLAHQRAFVMVPWLDVDPAAELTAPEGPRPVAALLAGLPPADRASVRL 168 >gi|118619362|ref|YP_907694.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK [Mycobacterium ulcerans Agy99] gi|118571472|gb|ABL06223.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK [Mycobacterium ulcerans Agy99] Length=175 Score = 216 bits (549), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 112/169 (67%), Positives = 126/169 (75%), Gaps = 1/169 (0%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+ VVLSVGSNLGDRLA LRSV DGLGD L+ AS +YE DPWGGV Q FLN VLIADDP Sbjct 1 MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPFLNVVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WL +AQE+ERAAGR R QRWGPR LDVDL+ACYQ + EV ++ LTLP Sbjct 61 ARDGHAWLHQAQEYERAAGRQRLQRWGPRTLDVDLVACYQ-AGPAGRTEVRCNDSILTLP 119 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRL 169 HPLAH RAFV++PW+ VDP A+LT PRPV LLA L PADR SVRL Sbjct 120 HPLAHQRAFVMVPWLDVDPAAELTGPEGPRPVAALLAGLPPADRASVRL 168 >gi|240172849|ref|ZP_04751508.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK [Mycobacterium kansasii ATCC 12478] Length=171 Score = 213 bits (543), Expect = 9e-54, Method: Compositional matrix adjust. Identities = 108/165 (66%), Positives = 129/165 (79%), Gaps = 1/165 (0%) Query 5 VLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEP 64 +LS+GSNLGDRLA LRSV DGLGDAL+AAS +YE DPWGG+EQ FLNAVLIADDP + Sbjct 1 MLSIGSNLGDRLAHLRSVVDGLGDALVAASRVYETDPWGGIEQDPFLNAVLIADDPDRDC 60 Query 65 REWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLA 124 WL RA EFERAAGR+R +RWGPR LDVDL+ C + + + V+V + ++ L LPHPLA Sbjct 61 HAWLCRAHEFERAAGRMRDERWGPRTLDVDLVTCAEITPS-GRVDVLSDDSDLRLPHPLA 119 Query 125 HLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRL 169 HLR FV+IPW+ VDP A++ + PRPV LLAELEPADR SVRL Sbjct 120 HLRPFVMIPWLDVDPAAEVPLPDGPRPVAELLAELEPADRASVRL 164 >gi|118472499|ref|YP_890322.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium smegmatis str. MC2 155] gi|118173786|gb|ABK74682.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium smegmatis str. MC2 155] Length=178 Score = 211 bits (536), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 108/167 (65%), Positives = 125/167 (75%), Gaps = 5/167 (2%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VLS+GSNLGDRL RL+SV DGLG A+ A S +YE WG EQG FLNAVL+ADDP Sbjct 1 MTSTVLSIGSNLGDRLTRLQSVLDGLGPAVRAVSAVYETAAWGFEEQGPFLNAVLLADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRRAQE E AAGRVRGQRWGPR LDVDLI C+ + E+ +R+ LTLP Sbjct 61 DLDGHGWLRRAQELEAAAGRVRGQRWGPRTLDVDLITCHDGAD-----EIISRDEGLTLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSV 167 HPLAHLRAFVLIPW+ VDP A LTVAG RPV RLL+E++ ++RD V Sbjct 116 HPLAHLRAFVLIPWLDVDPDATLTVAGESRPVQRLLSEIDQSERDGV 162 >gi|126437716|ref|YP_001073407.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. JLS] gi|126237516|gb|ABO00917.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. JLS] Length=176 Score = 207 bits (528), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 104/168 (62%), Positives = 124/168 (74%), Gaps = 5/168 (2%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT+VVLS+GSN+GDRLARL+SV DGLG+A+ A SP+YE WGGVEQG FLNAVLIADDP Sbjct 1 MTKVVLSIGSNVGDRLARLQSVVDGLGEAVRAVSPVYETAAWGGVEQGAFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR Q+ E+ A RVRGQRWGPR LDVD++ C+ EV + LTLP Sbjct 61 DLDCHGWLRRGQQLEQEADRVRGQRWGPRTLDVDIVTCHDGD-----TEVRSATAELTLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AHLRAFVL+PW+A +P A LTVA RPV+ L EL+PA+R VR Sbjct 116 HPYAHLRAFVLMPWLAAEPEATLTVADTTRPVSLWLEELDPAERAGVR 163 >gi|333992535|ref|YP_004525149.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK [Mycobacterium sp. JDM601] gi|333488503|gb|AEF37895.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK [Mycobacterium sp. JDM601] Length=173 Score = 206 bits (525), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 103/169 (61%), Positives = 128/169 (76%), Gaps = 3/169 (1%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VLS+GSNLGDRLARL+S DG G A+ S +YE++ WGGV+QG+FLNAVLI +DP Sbjct 1 MTEAVLSIGSNLGDRLARLQSAVDGFGTAVREVSGVYESEAWGGVDQGRFLNAVLIVEDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WL RAQ+ E+AA RVRG+RWGPR LDVD+I+C + E+ +R++ LTLP Sbjct 61 AVDKHGWLHRAQDLEQAADRVRGERWGPRTLDVDVISCREQPGG---AELFSRDDGLTLP 117 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRL 169 HPLAHLRAFV++PW+AV+P AQLTVAG V LL ELEPADR S+RL Sbjct 118 HPLAHLRAFVMVPWLAVEPEAQLTVAGRQCAVAGLLDELEPADRTSLRL 166 >gi|108801729|ref|YP_641926.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. MCS] gi|119870880|ref|YP_940832.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. KMS] gi|108772148|gb|ABG10870.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. MCS] gi|119696969|gb|ABL94042.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. KMS] Length=176 Score = 204 bits (519), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 103/168 (62%), Positives = 122/168 (73%), Gaps = 5/168 (2%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTRVVLS+GSN+GDRLARL+SV DGLG+A+ A SP+YE WGGVEQG FLNAVLIADDP Sbjct 1 MTRVVLSIGSNVGDRLARLQSVVDGLGEAVRAVSPVYETAAWGGVEQGAFLNAVLIADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR Q+ E+ A RVRGQRWGPR LDVD++ C+ EV + LTLP Sbjct 61 DLDCHGWLRRGQQLEQEADRVRGQRWGPRTLDVDIVTCHDGD-----TEVRSATAELTLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AHLR FVL+PW+A +P A LTVA RPV+ L EL+ A+R VR Sbjct 116 HPYAHLRGFVLMPWLAAEPEATLTVADTTRPVSLWLEELDYAERAGVR 163 >gi|120406316|ref|YP_956145.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium vanbaalenii PYR-1] gi|119959134|gb|ABM16139.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium vanbaalenii PYR-1] Length=175 Score = 192 bits (488), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 98/168 (59%), Positives = 119/168 (71%), Gaps = 5/168 (2%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VVLS+GSNLGDR+A L+SV DGL + +A SP+YE D WGGVEQG FLNAV++A+D Sbjct 1 MTSVVLSIGSNLGDRMAHLQSVLDGLAGSALAVSPVYETDAWGGVEQGPFLNAVVLAEDR 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRRA E E AAGRVR QRWGPR LDVDL+ C+ EV ++ LTLP Sbjct 61 ELDGYGWLRRAHELEDAAGRVRDQRWGPRTLDVDLVQCHGPDG-----EVVVHDDVLTLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AH RAFVL+PW+ V+PTA LTV G P+T LA ++ A+R VR Sbjct 116 HPYAHARAFVLVPWLQVEPTATLTVDGRTDPLTAHLAAVDAAERAGVR 163 >gi|226304118|ref|YP_002764076.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Rhodococcus erythropolis PR4] gi|229494531|ref|ZP_04388294.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Rhodococcus erythropolis SK121] gi|226183233|dbj|BAH31337.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Rhodococcus erythropolis PR4] gi|229318893|gb|EEN84751.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Rhodococcus erythropolis SK121] Length=167 Score = 182 bits (463), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 90/168 (54%), Positives = 116/168 (70%), Gaps = 9/168 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTR VLS+GSN+GD +A L+SV DGLG A++A SP+Y PWGGVEQ F NAV++ DDP Sbjct 1 MTRAVLSIGSNIGDSVAHLQSVVDGLGSAVVAVSPVYSTAPWGGVEQQDFYNAVVVVDDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + EWLRR+Q E AA RVR QRWGPR+LDVD++ C +++ + LTLP Sbjct 61 EADAAEWLRRSQALEEAADRVREQRWGPRSLDVDVVDCEGVVSSDPV---------LTLP 111 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AHLRAFVL+PW+ V+P A L V G PV ++L L+ +R+ VR Sbjct 112 HPRAHLRAFVLVPWLDVEPDATLIVDGQKLPVAQILDGLDRTEREGVR 159 >gi|325675043|ref|ZP_08154730.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Rhodococcus equi ATCC 33707] gi|325554629|gb|EGD24304.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Rhodococcus equi ATCC 33707] Length=168 Score = 170 bits (430), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 88/168 (53%), Positives = 112/168 (67%), Gaps = 9/168 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS+GSN+GD LA L+ V DGL + ++A SP+Y PWGGVEQ FLNA+++ DDP Sbjct 1 MSRAVLSIGSNIGDSLAHLQGVVDGLREHVVAVSPVYATAPWGGVEQQDFLNAIVVVDDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR QE E +A RVR QRWGPR LDVD++ C + + LTLP Sbjct 61 GTDAHGWLRRGQELEASADRVREQRWGPRTLDVDVVTCDG---------IRIDDLELTLP 111 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AH RAFVL+PW+AV+P A L V G V LLA+L+ ++RD VR Sbjct 112 HPRAHERAFVLVPWLAVEPDATLDVDGVDVRVDELLAQLDASERDGVR 159 >gi|169627641|ref|YP_001701290.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium abscessus ATCC 19977] gi|169239608|emb|CAM60636.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase (FolK) [Mycobacterium abscessus] Length=172 Score = 169 bits (427), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 88/166 (54%), Positives = 115/166 (70%), Gaps = 6/166 (3%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS+GSN+GDRLA L+SV D LG ++ SP+Y+ PWG V Q F NA+++AD Sbjct 2 RAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDFFNAIVVAD--GR 59 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHP 122 EP EWL A E++A R+R +RWGPR LDVD+I+C + A E L + + LTLPHP Sbjct 60 EPLEWLAVAHRLEQSAQRLRDERWGPRTLDVDVISCRRHDAGEVLSD----DPDLTLPHP 115 Query 123 LAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 AHLRAFVL+PW+A++P A LTV G RPV LL+ L+ A+R+ VR Sbjct 116 RAHLRAFVLVPWLALEPGAVLTVDGVVRPVADLLSGLDAAEREGVR 161 >gi|54022366|ref|YP_116608.1| putative 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Nocardia farcinica IFM 10152] gi|54013874|dbj|BAD55244.1| putative 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Nocardia farcinica IFM 10152] Length=181 Score = 169 bits (427), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 89/168 (53%), Positives = 106/168 (64%), Gaps = 5/168 (2%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS+GSNLGDRL LRSV D + D L+A S +Y PWGGVEQ FLNA+L+ DDP Sbjct 1 MSRAVLSIGSNLGDRLGYLRSVVDAVADRLVAVSSVYTTAPWGGVEQDDFLNAILVVDDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 R+WL Q ERAA R R RWG R LDVD+I C V + + LT+P Sbjct 61 DRGCRDWLALGQRLERAAHRTRAVRWGARTLDVDVIWCADADGP-----VVSADPELTVP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AH RAFVLIPW+ +P A+L V R V LA L+PA+RD VR Sbjct 116 HPRAHERAFVLIPWLEAEPHARLAVGDVERSVRDWLAALDPAERDGVR 163 >gi|312138056|ref|YP_004005392.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Rhodococcus equi 103S] gi|311887395|emb|CBH46707.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinediphosphokinase [Rhodococcus equi 103S] Length=168 Score = 166 bits (421), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 87/168 (52%), Positives = 112/168 (67%), Gaps = 9/168 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS+GSN+GD LA L+ V DGL + ++A SP+Y PWGGVEQ FLNA+++ DD Sbjct 1 MSRAVLSIGSNIGDSLAHLQGVVDGLREHVVAVSPVYATAPWGGVEQLDFLNAIVVVDDL 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR QE E +A RVR QRWGPR LDVD++ C + + + LTLP Sbjct 61 GTDAHGWLRRGQELEASADRVREQRWGPRTLDVDVVTCDG---------IRSDDPELTLP 111 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AH RAFVL+PW+AV+P A L V G V LLA+L+ ++RD VR Sbjct 112 HPRAHERAFVLVPWLAVEPDATLDVDGVDVRVDELLAQLDASERDGVR 159 >gi|145222012|ref|YP_001132690.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium gilvum PYR-GCK] gi|145214498|gb|ABP43902.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium gilvum PYR-GCK] Length=168 Score = 165 bits (417), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 80/134 (60%), Positives = 95/134 (71%), Gaps = 5/134 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VVLS+GSNLGDRLA L+SV D LG A+ SP+YE D WGGVEQG FLNA+++A+DP Sbjct 1 MTSVVLSIGSNLGDRLAHLQSVLDALGPAVTGVSPVYETDAWGGVEQGPFLNAIVLAEDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRRA E E A GR R Q WGPR LDVDL++C A E+ + LTLP Sbjct 61 ALDAHGWLRRAHELEDACGRTREQHWGPRTLDVDLVSCRDGDA-----EIVMDDPDLTLP 115 Query 121 HPLAHLRAFVLIPW 134 HP AH+RAFVL+PW Sbjct 116 HPYAHVRAFVLVPW 129 >gi|315446248|ref|YP_004079127.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. Spyr1] gi|315264551|gb|ADU01293.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Mycobacterium sp. Spyr1] Length=171 Score = 163 bits (412), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 80/134 (60%), Positives = 94/134 (71%), Gaps = 5/134 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VVLS+GSNLGDRLA L+SV D LG A+ SP+YE D WGGVEQ FLNAV++A+DP Sbjct 1 MTSVVLSIGSNLGDRLAHLQSVLDALGPAVTGVSPVYETDAWGGVEQSPFLNAVVLAEDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRRA E E A GR R Q WGPR LDVDL++C A E+ + LTLP Sbjct 61 ALDAHGWLRRAHELEDACGRTREQHWGPRTLDVDLVSCRDGDA-----EIVMDDPDLTLP 115 Query 121 HPLAHLRAFVLIPW 134 HP AH+RAFVL+PW Sbjct 116 HPYAHVRAFVLVPW 129 >gi|331699839|ref|YP_004336078.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Pseudonocardia dioxanivorans CB1190] gi|326954528|gb|AEA28225.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Pseudonocardia dioxanivorans CB1190] Length=174 Score = 160 bits (405), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 86/163 (53%), Positives = 105/163 (65%), Gaps = 5/163 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTR VLS+GSNLGDR+A LR+V D + D L+AASP+YE PWGG+EQ FLNAV++ DDP Sbjct 1 MTRAVLSLGSNLGDRIAHLRAVVDDMADVLVAASPVYETAPWGGIEQPDFLNAVIVVDDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR Q E+AA RVR QRWGPR LDVD++A A +V + + L LP Sbjct 61 GTDAWGWLRRGQRLEQAAHRVREQRWGPRTLDVDVVAVTADGA-----DVISDDPELVLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPAD 163 HP RA VL+PW+ VDP A L G R + L E AD Sbjct 116 HPGTSERATVLVPWLDVDPGAVLAGRGPVRTLLDALPAGEIAD 158 >gi|226363737|ref|YP_002781519.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Rhodococcus opacus B4] gi|226242226|dbj|BAH52574.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Rhodococcus opacus B4] Length=170 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 91/179 (51%), Positives = 110/179 (62%), Gaps = 9/179 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS+GSN+GD LA L+SV DGLGDA++A SP+Y PWGGVEQ FLNAV++ADDP Sbjct 1 MSRAVLSIGSNVGDSLAHLQSVLDGLGDAVVAVSPVYSTAPWGGVEQQDFLNAVVVADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR QE E AA RVR +RWGPR L +V + + LTLP Sbjct 61 ALDGWGWLRRGQELEAAADRVRVERWGPRTL---------DVDVVTCDDVRSDDPELTLP 111 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSR 179 HP AH RAFVLIPW+ V+P A L V G V LL L+ +R V + D SR Sbjct 112 HPRAHERAFVLIPWLDVEPDAVLPVDGTTTRVDVLLPLLDDEERAGVHRTGLALDRRSR 170 >gi|343924374|ref|ZP_08763924.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Gordonia alkanivorans NBRC 16433] gi|343765706|dbj|GAA10850.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Gordonia alkanivorans NBRC 16433] Length=175 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 88/168 (53%), Positives = 105/168 (63%), Gaps = 6/168 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS GSN+GD L LRSV +G GD L+A S +Y PWGG+EQ FLN LI D P Sbjct 1 MSRAVLSAGSNVGDSLGHLRSVVEGFGDELVAVSAVYATPPWGGIEQDDFLNITLIVDGP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 R+WL R E E+AA R R RWGPR LDVD+I S TEA V + LTLP Sbjct 61 -LSARQWLDRGNELEQAADRTREVRWGPRTLDVDVI-----SVTEAGGVVVDDDPVLTLP 114 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP A RAFVLIPW+ ++P A L RPV L+ L+ A+RD+VR Sbjct 115 HPRAAQRAFVLIPWLEIEPEATLWTPEGERPVRELIDALDAAERDAVR 162 >gi|111021383|ref|YP_704355.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Rhodococcus jostii RHA1] gi|110820913|gb|ABG96197.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Rhodococcus jostii RHA1] Length=170 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 94/179 (53%), Positives = 113/179 (64%), Gaps = 9/179 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS+GSN+GD LA L+SV DGLGDA++A SP+Y PWGGVEQ FLNAVL+ DDP Sbjct 1 MSRAVLSIGSNVGDSLAHLQSVLDGLGDAVVAVSPVYSTAPWGGVEQQDFLNAVLVVDDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR QE E AA RVR +RWGPR LDVD++ C + + LTLP Sbjct 61 ALDGYGWLRRGQELEAAADRVRIERWGPRTLDVDVVTCDDVRSDDP---------ELTLP 111 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSR 179 HP AH RAFVLIPW+ V+P A L V G V LL L+ +R V + D SR Sbjct 112 HPRAHERAFVLIPWLDVEPEAVLRVDGTTTRVDALLPLLDDDERAGVHRTQLVLDRRSR 170 >gi|296392858|ref|YP_003657742.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Segniliparus rotundus DSM 44985] gi|296180005|gb|ADG96911.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Segniliparus rotundus DSM 44985] Length=177 Score = 152 bits (383), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 84/168 (50%), Positives = 103/168 (62%), Gaps = 5/168 (2%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VLS+GSNLG+RL L+ LGD ++AAS +YE DPWG F NAVL+A DP Sbjct 1 MTTAVLSLGSNLGNRLGFLQLAVASLGDRVLAASSVYETDPWG-TAGPNFFNAVLMASDP 59 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + R WL A E AGR R WGPR LDVD+IACY +V+ E L++P Sbjct 60 ALDARGWLDEAFRAEALAGRTRETVWGPRTLDVDVIACYDEDGAPVVVD----EPTLSVP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP AH RAFVL+PW+ V P A+L V G V L+A+L A+R SVR Sbjct 116 HPRAHQRAFVLVPWLQVQPQARLAVGGEDISVRELIAQLAQAERASVR 163 >gi|296138299|ref|YP_003645542.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Tsukamurella paurometabola DSM 20162] gi|296026433|gb|ADG77203.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase [Tsukamurella paurometabola DSM 20162] Length=162 Score = 149 bits (375), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 83/159 (53%), Positives = 103/159 (65%), Gaps = 8/159 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTR VLS+G+NLGD +R LG AL+AASP+Y PWGGVEQ F+NA ++ADDP Sbjct 1 MTRAVLSIGANLGDAETAVRGAITALGPALVAASPLYRTPPWGGVEQDDFINATVLADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WL A++ E AA R+R RWGPR LDVD+IA + +A V + + + LTLP Sbjct 61 SRTAAGWLDFARDQEAAADRIRDVRWGPRTLDVDVIAVW-----DAEVPIRSDDPELTLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAEL 159 HP AH RAFVL+PW AVDP A+L G V LLA L Sbjct 116 HPRAHQRAFVLVPWRAVDPAAELPGHGT---VDDLLAAL 151 >gi|262203868|ref|YP_003275076.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase [Gordonia bronchialis DSM 43247] gi|262087215|gb|ACY23183.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase [Gordonia bronchialis DSM 43247] Length=171 Score = 147 bits (370), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 85/168 (51%), Positives = 97/168 (58%), Gaps = 6/168 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTR VLS GSN+GDR A L SV G D LIA S +Y PWGGVEQ F N LI D P Sbjct 1 MTRAVLSAGSNIGDRNAHLASVVSGFADELIAVSHVYATPPWGGVEQDDFHNITLIVDGP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 P +WL R ERAA RVR RWGPR LDVD+I+ V + + LTLP Sbjct 61 LT-PAQWLARGLRLERAADRVREVRWGPRTLDVDVISVIGPDGP-----VISDDPDLTLP 114 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 HP A RAFVLIPW+ +DP A L PV L+ L+ A+R VR Sbjct 115 HPRAAERAFVLIPWLEIDPDATLWTPAGEIPVAELVERLDDAERRDVR 162 >gi|325000123|ref|ZP_08121235.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase [Pseudonocardia sp. P1] Length=531 Score = 140 bits (353), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 79/167 (48%), Positives = 99/167 (60%), Gaps = 8/167 (4%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MTR VLS+GSN+GDR+ LR+V LG AL+ SP++E PWG +Q FLNAV++ADDP Sbjct 1 MTRAVLSLGSNMGDRIGHLRAVVADLGPALVVVSPVFETAPWGVTDQPDFLNAVVVADDP 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + WLRR Q E A+GRVR QRWGPR LDVD++ V + + L LP Sbjct 61 ALDAWGWLRRGQALEDASGRVREQRWGPRTLDVDVLQVRDGDEP-----VISDDPELLLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSV 167 HP RA VL+PW+ +P A L G PV LL L P R + Sbjct 116 HPGTPERATVLLPWLLAEPDAVLQGHG---PVADLLTRLGPDARSGI 159 >gi|271970336|ref|YP_003344532.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Streptosporangium roseum DSM 43021] gi|270513511|gb|ACZ91789.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin ediphosphokinase [Streptosporangium roseum DSM 43021] Length=165 Score = 139 bits (350), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 88/171 (52%), Positives = 104/171 (61%), Gaps = 21/171 (12%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDA----LIAASPIYEADPWGGVEQGQFLNAVLIAD 58 +VVL++GSNLGDR L+ D L DA +A SP+YE DP+GG EQG +LNAV+IA Sbjct 2 KVVLALGSNLGDRFDTLQGALDSLFDAPGLEFVAVSPVYETDPFGGPEQGPYLNAVVIAH 61 Query 59 DPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLT 118 T EPR L RAQ E A GRVR +RWG R LDVDLI +V + + LT Sbjct 62 S-TLEPRTLLDRAQGVENAFGRVRAERWGARTLDVDLITVG---------DVVSDDPELT 111 Query 119 LPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRL 169 LPHP AH RAFVL+PW DP A L+ R V LLA L D+D VRL Sbjct 112 LPHPRAHERAFVLVPWSRADPDAVLS----GRRVDDLLAAL---DQDYVRL 155 >gi|255325840|ref|ZP_05366932.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium tuberculostearicum SK141] gi|255297052|gb|EET76377.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium tuberculostearicum SK141] Length=161 Score = 137 bits (344), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 78/167 (47%), Positives = 102/167 (62%), Gaps = 16/167 (9%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIAD-DPT 61 R VLS+GSN+ DR+ LR+V D ++AASP+Y PWG +Q +FLNAVLI D D T Sbjct 2 RAVLSIGSNMDDRVELLRTVFDEFAGEIVAASPVYATPPWGVTDQDEFLNAVLIVDVDET 61 Query 62 CEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPH 121 P+E LRR Q+ E AA RVR + WGPR LDVD+I T+ + L +PH Sbjct 62 --PKELLRRGQKLEEAAERVRVRHWGPRTLDVDIIDIEG---------YTSEDPELIVPH 110 Query 122 PLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 P H RAFVLIPW+A D A+L+ G V + +A L+P +R +R Sbjct 111 PYGHERAFVLIPWLAADAGARLSGEG----VAKRVAALDPKERAEIR 153 >gi|311740147|ref|ZP_07713979.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium pseudogenitalium ATCC 33035] gi|311304702|gb|EFQ80773.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium pseudogenitalium ATCC 33035] Length=161 Score = 136 bits (342), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 76/166 (46%), Positives = 101/166 (61%), Gaps = 14/166 (8%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS+GSN+ DR+ LR+V D ++AASP+Y PWG +Q +FLNAVLI D Sbjct 2 RAVLSIGSNMDDRVELLRTVFDEFAGEIVAASPVYATPPWGVTDQDEFLNAVLIVDVEET 61 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHP 122 P+E LRR Q+ E AA RVR + WGPR LDVD++ T+ + L +PHP Sbjct 62 -PKELLRRGQKLEEAAERVRVRHWGPRTLDVDIVDIEG---------YTSDDPELIVPHP 111 Query 123 LAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 AH RAFVLIPW+A D A+L+ G V + +A L+P +R +R Sbjct 112 YAHERAFVLIPWLAADAGARLSGEG----VAKRVAALDPQERADIR 153 >gi|305680505|ref|ZP_07403313.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium matruchotii ATCC 14266] gi|305660036|gb|EFM49535.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium matruchotii ATCC 14266] Length=161 Score = 135 bits (339), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 78/167 (47%), Positives = 102/167 (62%), Gaps = 9/167 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M R VLS+GSN+ DR A L +V + D IA SPIY PWG +Q +FLNA+LI + Sbjct 1 MIRAVLSIGSNMDDRYALLETVFEEFRDETIAQSPIYSTPPWGVPDQDEFLNAILIVNVA 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 PRE LRR Q E AA R R ++WGPR LDVD+I + VE+ + + L LP Sbjct 61 QT-PRELLRRGQHLEAAAERRRTRKWGPRTLDVDIIQVIDANG----VELVSEDPELILP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSV 167 HP A RAFVL+PW+A DP A+L G PV ++ +L+ AD ++V Sbjct 116 HPWARHRAFVLVPWLAADPEARLL--GV--PVREIVEKLDIADVEAV 158 >gi|317507807|ref|ZP_07965508.1| 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Segniliparus rugosus ATCC BAA-974] gi|316253849|gb|EFV13218.1| 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Segniliparus rugosus ATCC BAA-974] Length=177 Score = 135 bits (339), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 75/159 (48%), Positives = 93/159 (59%), Gaps = 5/159 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 MT VLS+GSNLG+RL L+ L + A S +YE DPWG V FLNAV++A DP Sbjct 1 MTTAVLSIGSNLGNRLGYLQLAVAALEKRVAAVSAVYETDPWGTVGP-NFLNAVIVASDP 59 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + R WL A E A R R + WGPR LDVD+IAC + T V+ + LT+P Sbjct 60 KLDERGWLGEAMRIEALAARTRERVWGPRTLDVDVIACTREDGT----SVSVADERLTVP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAEL 159 HP AH RAFVL PW+ V P A+L+V G V L+ L Sbjct 116 HPRAHERAFVLFPWLDVQPEARLSVDGWDVSVRELVDSL 154 >gi|225022116|ref|ZP_03711308.1| hypothetical protein CORMATOL_02149 [Corynebacterium matruchotii ATCC 33806] gi|224945049|gb|EEG26258.1| hypothetical protein CORMATOL_02149 [Corynebacterium matruchotii ATCC 33806] Length=161 Score = 135 bits (339), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 78/167 (47%), Positives = 102/167 (62%), Gaps = 9/167 (5%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M R VLS+GSN+ DR A L +V + D IA SPIY PWG +Q +FLNA+LI + Sbjct 1 MIRAVLSIGSNMDDRYALLETVFEEFRDETIAQSPIYSTPPWGVPDQDEFLNAILIVNVA 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 PRE LRR Q E AA R R ++WGPR LDVD+I + VE+ + + L LP Sbjct 61 QT-PRELLRRGQRLEAAAERRRTRKWGPRTLDVDIIQVIDANG----VELVSEDPELILP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSV 167 HP A RAFVL+PW+A DP A+L G PV ++ +L+ AD ++V Sbjct 116 HPWARHRAFVLVPWLAADPEARLL--GV--PVREIVEKLDIADVEAV 158 >gi|227547911|ref|ZP_03977960.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium lipophiloflavum DSM 44291] gi|227080016|gb|EEI17979.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium lipophiloflavum DSM 44291] Length=152 Score = 134 bits (338), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 79/157 (51%), Positives = 94/157 (60%), Gaps = 12/157 (7%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS GSN+ D A L SV D D L+AAS +Y PWGGVEQ FLN VLI D Sbjct 2 RAVLSTGSNIEDSRAHLASVVDEFADELVAASCLYATAPWGGVEQNDFLNQVLIVDVEQS 61 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVE-VTARENHLTLPH 121 P E LRR Q E+ A RVR +RWGPR LDVD++ L++ T+R LT+PH Sbjct 62 -PIELLRRCQSLEQRARRVREKRWGPRTLDVDIV----------LIDGFTSRNPELTVPH 110 Query 122 PLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAE 158 P AH RAFVL+PW+ +DP AQL V +L AE Sbjct 111 PRAHERAFVLVPWLEIDPDAQLGGRSVAGIVDKLGAE 147 >gi|227834062|ref|YP_002835769.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Corynebacterium aurimucosum ATCC 700975] gi|262183452|ref|ZP_06042873.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Corynebacterium aurimucosum ATCC 700975] gi|227455078|gb|ACP33831.1| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Corynebacterium aurimucosum ATCC 700975] Length=156 Score = 133 bits (334), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 77/166 (47%), Positives = 100/166 (61%), Gaps = 14/166 (8%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS+GSN+ DR A L++V D +AASP++ PWG +Q +FLNAVLI D C Sbjct 2 RAVLSIGSNMEDRRALLQTVFDEFAAETVAASPVFATPPWGVTDQDEFLNAVLIV-DVEC 60 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHP 122 P E LRR Q+ E AA RVR + WGPR LDVD++ VT+ + LTLPHP Sbjct 61 TPLELLRRGQKLEEAAERVRVRHWGPRTLDVDIVQIDG---------VTSDDPELTLPHP 111 Query 123 LAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 AH RAFVL+PW+A D A+L PV L+A L+ + +V+ Sbjct 112 YAHERAFVLVPWLAADEHARLN----GTPVRELIAGLDEDEVAAVK 153 >gi|296118969|ref|ZP_06837542.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium ammoniagenes DSM 20306] gi|295968067|gb|EFG81319.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium ammoniagenes DSM 20306] Length=161 Score = 132 bits (332), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 77/168 (46%), Positives = 101/168 (61%), Gaps = 14/168 (8%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS+GSN+ DR+ L++V D D +IAASP+Y PWG +Q +FLNAV+I D Sbjct 2 RAVLSIGSNMDDRVKLLKTVFDEFSDDIIAASPVYSTPPWGVEDQDEFLNAVIIVDVEQT 61 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHP 122 P E L R Q E+AA RVR + WGPR LDVD++ S+ + LT+PHP Sbjct 62 -PLELLHRGQALEQAADRVRVRHWGPRTLDVDIVEIEGFSSN---------TDELTVPHP 111 Query 123 LAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLF 170 A RAFVLIPW+A D A T+AG +PV L+ L AD D +++ Sbjct 112 HAAQRAFVLIPWMAADVHA--TLAG--QPVAGLIGMLPQADIDGIKVL 155 >gi|284989217|ref|YP_003407771.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Geodermatophilus obscurus DSM 43160] gi|284062462|gb|ADB73400.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Geodermatophilus obscurus DSM 43160] Length=168 Score = 132 bits (331), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 83/165 (51%), Positives = 100/165 (61%), Gaps = 10/165 (6%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGD--ALIAASPIYEADPWGGVEQGQFLNAVLIAD 58 MTR VLS+G+NLGDR A LR+ L D L+A S +YEA PWG VEQ +LNAV++ Sbjct 1 MTRAVLSLGANLGDRAAALRTAVTTLKDDGVLVARSTLYEAPPWGPVEQPPYLNAVVVVR 60 Query 59 DPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLT 118 + WL RA E E+AAGR R RWGPR LDVD++ L + A LT Sbjct 61 G-DRDAAGWLARAHELEQAAGRSRDVRWGPRTLDVDVVTATGDDGQPVLSDDPA----LT 115 Query 119 LPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPAD 163 LPHP AH RAFVL+PW ++DPTA L G V+ LLA L P D Sbjct 116 LPHPRAHERAFVLVPWASLDPTAVLPGRGR---VSDLLAALPPED 157 >gi|38234561|ref|NP_940328.1| putative 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Corynebacterium diphtheriae NCTC 13129] gi|38200824|emb|CAE50528.1| Putative 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Corynebacterium diphtheriae] Length=159 Score = 130 bits (327), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 69/141 (49%), Positives = 88/141 (63%), Gaps = 5/141 (3%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS+GSN+ DR A LR+V + ++AAS IY PWG +Q +FLNAV+I D + Sbjct 2 RAVLSIGSNMDDRYALLRTVVEEFAGQIVAASSIYSTPPWGVEDQYEFLNAVVIVDVDSS 61 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHP 122 P E LRR Q E AA R R + WGPR LDVD++ Y T ++ + + LTLPHP Sbjct 62 -PLELLRRGQRLEEAACRRRLRHWGPRTLDVDVVTIYNDDGT----QMRSTDPELTLPHP 116 Query 123 LAHLRAFVLIPWIAVDPTAQL 143 AH RAFVL+PW DP A+L Sbjct 117 YAHERAFVLVPWAEADPEAEL 137 >gi|213965103|ref|ZP_03393301.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Corynebacterium amycolatum SK46] gi|213952217|gb|EEB63601.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Corynebacterium amycolatum SK46] Length=170 Score = 130 bits (326), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 77/169 (46%), Positives = 97/169 (58%), Gaps = 8/169 (4%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M R VLS+G+N+ L V D L+AAS IY PWGGVEQG FLNAVLI D Sbjct 1 MIRAVLSIGANMDRARENLTGVQAFFADELVAASKIYATPPWGGVEQGDFLNAVLIV-DT 59 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + P E L + E AGRVR WGPR LDVD++ + E E+ + ++ LTLP Sbjct 60 SRTPVELLEAGWKLENDAGRVREIHWGPRALDVDIVQIIDKDSGE---EIISADSTLTLP 116 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRL 169 HP A RAFVL+PW+ DP A+L V L+ +L P D ++VRL Sbjct 117 HPWATERAFVLVPWLDADPDAELEGV----RVAELVDKLAPEDVNAVRL 161 >gi|256374472|ref|YP_003098132.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase [Actinosynnema mirum DSM 43827] gi|255918775|gb|ACU34286.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase [Actinosynnema mirum DSM 43827] Length=158 Score = 129 bits (323), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 78/147 (54%), Positives = 91/147 (62%), Gaps = 10/147 (6%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS+GSNLGDRLA LRS DG L+AASP+YE PWG +Q FLNAVL+ + Sbjct 1 MSRAVLSLGSNLGDRLAHLRSAVDGFRPWLLAASPVYETAPWGVTDQDDFLNAVLLVEGD 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 E WLRR QE ERAAGRVR +RWGPR L A+ +V + + L LP Sbjct 61 LDE-WGWLRRGQELERAAGRVRERRWGPRTL---------DVDVVAVDDVRSEDPELLLP 110 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAG 147 HP AH RA VL PW+ VDP A L G Sbjct 111 HPGAHERATVLAPWLDVDPDAVLPGHG 137 >gi|306836923|ref|ZP_07469876.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium accolens ATCC 49726] gi|304567194|gb|EFM42806.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium accolens ATCC 49726] Length=161 Score = 128 bits (322), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 73/161 (46%), Positives = 98/161 (61%), Gaps = 14/161 (8%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS+GSN+ DR+ LR+V + ++AASP+Y PWG +Q +FLNAVLI D Sbjct 2 RAVLSIGSNMDDRVELLRTVFTEFREDIVAASPVYSTPPWGVTDQDEFLNAVLIVDVQES 61 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHP 122 P E L R Q+ E AA RVR + WGPR LDVD++ S+++ LT+PHP Sbjct 62 -PLELLCRGQKLEEAAERVRVRHWGPRTLDVDIVDIEGYSSSDP---------ELTVPHP 111 Query 123 LAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPAD 163 AH RAFVLIPW+A D A+L + V+ L+A L+P + Sbjct 112 FAHERAFVLIPWLAADGAAKLK----GKDVSALVAALDPQE 148 >gi|227505945|ref|ZP_03935994.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium striatum ATCC 6940] gi|227197467|gb|EEI77515.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Corynebacterium striatum ATCC 6940] Length=155 Score = 128 bits (322), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 73/166 (44%), Positives = 98/166 (60%), Gaps = 14/166 (8%) Query 3 RVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTC 62 R VLS+GSN+ DR A L++V D + +A SP+Y PWG +Q +FLNAVLI + Sbjct 2 RAVLSIGSNMDDRRALLQTVFDEFAEETVAVSPVYSTPPWGVEDQDEFLNAVLIV-EVNS 60 Query 63 EPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHP 122 P E LRR Q E+ A RVR + WGPR LDVD++ +T+ + LTLPHP Sbjct 61 TPMELLRRGQGLEQDAERVRVRHWGPRTLDVDIVQVDG---------ITSEDPELTLPHP 111 Query 123 LAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVR 168 A RAFVL+PW+A DP A+L V L+A L+P + + V+ Sbjct 112 FARERAFVLVPWLAADPKARLGDTA----VADLVAGLDPHEVEQVK 153 >gi|258651096|ref|YP_003200252.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Nakamurella multipartita DSM 44233] gi|258554321|gb|ACV77263.1| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase [Nakamurella multipartita DSM 44233] Length=163 Score = 127 bits (318), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 70/148 (48%), Positives = 86/148 (59%), Gaps = 5/148 (3%) Query 1 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP 60 M+R VLS+GSN+GDR A L++ + LG + A S IY PWGGV Q + N V+IA+D Sbjct 1 MSRAVLSLGSNVGDRTAHLQTAVNSLGRTVRAVSSIYRTPPWGGVPQPDYYNLVVIAEDD 60 Query 61 TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP 120 + W R Q E+ AGR R RWGPR LD D+I V + E LTLP Sbjct 61 GNDAHAWWERCQALEQEAGRERTIRWGPRTLDADVIVVEVHGHA-----VISDEPELTLP 115 Query 121 HPLAHLRAFVLIPWIAVDPTAQLTVAGC 148 HP A RAFVL PW +DPTA+L AG Sbjct 116 HPRAAQRAFVLRPWAEIDPTAELPGAGA 143 Lambda K H 0.321 0.136 0.420 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 183812957610 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40