BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3646c Length=934 Score E Sequences producing significant alignments: (Bits) Value gi|148824848|ref|YP_001289602.1| DNA topoisomerase I [Mycobacter... 1877 0.0 gi|15610782|ref|NP_218163.1| DNA topoisomerase I [Mycobacterium ... 1877 0.0 gi|121639559|ref|YP_979783.1| DNA topoisomerase I [Mycobacterium... 1876 0.0 gi|289441076|ref|ZP_06430820.1| DNA topoisomerase I topA [Mycoba... 1875 0.0 gi|289748160|ref|ZP_06507538.1| DNA topoisomerase I topA [Mycoba... 1870 0.0 gi|183985106|ref|YP_001853397.1| DNA topoisomerase I TopA [Mycob... 1621 0.0 gi|240173037|ref|ZP_04751695.1| DNA topoisomerase I [Mycobacteri... 1617 0.0 gi|254821836|ref|ZP_05226837.1| DNA topoisomerase I [Mycobacteri... 1606 0.0 gi|118619392|ref|YP_907724.1| DNA topoisomerase I [Mycobacterium... 1604 0.0 gi|118463766|ref|YP_879799.1| DNA topoisomerase I [Mycobacterium... 1593 0.0 gi|41406523|ref|NP_959359.1| DNA topoisomerase I [Mycobacterium ... 1589 0.0 gi|296166702|ref|ZP_06849127.1| DNA topoisomerase TopA [Mycobact... 1583 0.0 gi|1395205|gb|AAC44599.1| topoisomerase I [Mycobacterium tubercu... 1582 0.0 gi|15827005|ref|NP_301268.1| DNA topoisomerase I [Mycobacterium ... 1581 0.0 gi|342862017|ref|ZP_08718661.1| DNA topoisomerase I subunit omeg... 1570 0.0 gi|336460892|gb|EGO39776.1| DNA topoisomerase I, bacterial [Myco... 1560 0.0 gi|333992571|ref|YP_004525185.1| DNA topoisomerase I TopA [Mycob... 1512 0.0 gi|118467403|ref|YP_890377.1| DNA topoisomerase I [Mycobacterium... 1488 0.0 gi|120406344|ref|YP_956173.1| DNA topoisomerase I [Mycobacterium... 1457 0.0 gi|145221986|ref|YP_001132664.1| DNA topoisomerase I [Mycobacter... 1455 0.0 gi|315446274|ref|YP_004079153.1| DNA topoisomerase I [Mycobacter... 1453 0.0 gi|108801759|ref|YP_641956.1| DNA topoisomerase I [Mycobacterium... 1453 0.0 gi|169627593|ref|YP_001701242.1| DNA topoisomerase I [Mycobacter... 1451 0.0 gi|339296459|gb|AEJ48570.1| DNA topoisomerase I [Mycobacterium t... 1396 0.0 gi|54022331|ref|YP_116573.1| DNA topoisomerase I [Nocardia farci... 1355 0.0 gi|333917966|ref|YP_004491547.1| DNA topoisomerase [Amycolicicoc... 1333 0.0 gi|331694279|ref|YP_004330518.1| DNA topoisomerase I [Pseudonoca... 1333 0.0 gi|343926496|ref|ZP_08766001.1| DNA topoisomerase I [Gordonia al... 1319 0.0 gi|262200589|ref|YP_003271797.1| DNA topoisomerase I [Gordonia b... 1318 0.0 gi|312138019|ref|YP_004005355.1| DNA topoisomerase i [Rhodococcu... 1313 0.0 gi|325675218|ref|ZP_08154903.1| DNA topoisomerase TopA [Rhodococ... 1310 0.0 gi|326383464|ref|ZP_08205151.1| DNA topoisomerase I subunit omeg... 1305 0.0 gi|226304002|ref|YP_002763960.1| DNA topoisomerase I [Rhodococcu... 1303 0.0 gi|229494794|ref|ZP_04388550.1| putative DNA topoisomerase I [Rh... 1302 0.0 gi|256374446|ref|YP_003098106.1| DNA topoisomerase I [Actinosynn... 1300 0.0 gi|226363673|ref|YP_002781455.1| DNA topoisomerase I [Rhodococcu... 1300 0.0 gi|111021329|ref|YP_704301.1| DNA topoisomerase I [Rhodococcus j... 1296 0.0 gi|257057531|ref|YP_003135363.1| DNA topoisomerase I [Saccharomo... 1284 0.0 gi|300790598|ref|YP_003770889.1| DNA topoisomerase IA [Amycolato... 1266 0.0 gi|302530814|ref|ZP_07283156.1| DNA topoisomerase I [Streptomyce... 1263 0.0 gi|134096990|ref|YP_001102651.1| DNA topoisomerase I [Saccharopo... 1261 0.0 gi|296394983|ref|YP_003659867.1| DNA topoisomerase I [Segnilipar... 1240 0.0 gi|296141547|ref|YP_003648790.1| DNA topoisomerase I [Tsukamurel... 1238 0.0 gi|325002272|ref|ZP_08123384.1| DNA topoisomerase I subunit omeg... 1228 0.0 gi|258650985|ref|YP_003200141.1| DNA topoisomerase I [Nakamurell... 1218 0.0 gi|317508883|ref|ZP_07966522.1| DNA topoisomerase I [Segniliparu... 1217 0.0 gi|336326561|ref|YP_004606527.1| DNA topoisomerase I [Corynebact... 1173 0.0 gi|172041528|ref|YP_001801242.1| DNA topoisomerase I [Corynebact... 1169 0.0 gi|334563526|ref|ZP_08516517.1| DNA topoisomerase I subunit omeg... 1164 0.0 gi|213966048|ref|ZP_03394237.1| putative DNA topoisomerase I [Co... 1161 0.0 >gi|148824848|ref|YP_001289602.1| DNA topoisomerase I [Mycobacterium tuberculosis F11] gi|148723375|gb|ABR08000.1| DNA topoisomerase I topA (omega-protein) [Mycobacterium tuberculosis F11] Length=934 Score = 1877 bits (4862), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/934 (99%), Positives = 934/934 (100%), Gaps = 0/934 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP Sbjct 1 MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA Sbjct 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART Sbjct 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY Sbjct 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG Sbjct 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR Sbjct 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG Sbjct 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE Sbjct 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA Sbjct 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 Query 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE Sbjct 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 Query 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNAS+RKGDDVASITDER Sbjct 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASMRKGDDVASITDER 900 Query 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD Sbjct 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 >gi|15610782|ref|NP_218163.1| DNA topoisomerase I [Mycobacterium tuberculosis H37Rv] gi|15843258|ref|NP_338295.1| DNA topoisomerase I [Mycobacterium tuberculosis CDC1551] gi|31794816|ref|NP_857309.1| DNA topoisomerase I [Mycobacterium bovis AF2122/97] 64 more sequence titles Length=934 Score = 1877 bits (4861), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/934 (99%), Positives = 934/934 (100%), Gaps = 0/934 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP Sbjct 1 MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA Sbjct 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART Sbjct 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY Sbjct 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG Sbjct 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR Sbjct 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG Sbjct 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE Sbjct 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA Sbjct 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 Query 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE Sbjct 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 Query 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER Sbjct 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 Query 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD Sbjct 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 >gi|121639559|ref|YP_979783.1| DNA topoisomerase I [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224992056|ref|YP_002646745.1| DNA topoisomerase I [Mycobacterium bovis BCG str. Tokyo 172] gi|121495207|emb|CAL73693.1| DNA topoisomerase I topA [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224775171|dbj|BAH27977.1| DNA topoisomerase I [Mycobacterium bovis BCG str. Tokyo 172] gi|341603580|emb|CCC66261.1| DNA topoisomerase I topA [Mycobacterium bovis BCG str. Moreau RDJ] Length=934 Score = 1876 bits (4860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/934 (99%), Positives = 933/934 (99%), Gaps = 0/934 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP Sbjct 1 MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA Sbjct 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART Sbjct 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY Sbjct 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG Sbjct 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR Sbjct 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 TNWLNNFYFGGDHGVPDSVARSGGLKK VGINLEGIDAREVNSIKLFDDTHGRPIYVRVG Sbjct 601 TNWLNNFYFGGDHGVPDSVARSGGLKKFVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE Sbjct 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA Sbjct 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 Query 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE Sbjct 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 Query 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER Sbjct 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 Query 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD Sbjct 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 >gi|289441076|ref|ZP_06430820.1| DNA topoisomerase I topA [Mycobacterium tuberculosis T46] gi|289571883|ref|ZP_06452110.1| DNA topoisomerase I topA [Mycobacterium tuberculosis T17] gi|289755772|ref|ZP_06515150.1| Swivelase [Mycobacterium tuberculosis EAS054] gi|289413995|gb|EFD11235.1| DNA topoisomerase I topA [Mycobacterium tuberculosis T46] gi|289545637|gb|EFD49285.1| DNA topoisomerase I topA [Mycobacterium tuberculosis T17] gi|289696359|gb|EFD63788.1| Swivelase [Mycobacterium tuberculosis EAS054] Length=934 Score = 1875 bits (4857), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/934 (99%), Positives = 934/934 (100%), Gaps = 0/934 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP Sbjct 1 MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA Sbjct 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART Sbjct 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY Sbjct 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG Sbjct 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR Sbjct 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG Sbjct 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLERLVAGDTGEPTPQRANLS+SITPDELTLQVAEELFATPQQGRTLGLDPETGHE Sbjct 661 KNGPYLERLVAGDTGEPTPQRANLSESITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA Sbjct 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 Query 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE Sbjct 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 Query 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER Sbjct 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 Query 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD Sbjct 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 >gi|289748160|ref|ZP_06507538.1| DNA topoisomerase I topA [Mycobacterium tuberculosis T92] gi|289688747|gb|EFD56176.1| DNA topoisomerase I topA [Mycobacterium tuberculosis T92] Length=934 Score = 1870 bits (4844), Expect = 0.0, Method: Compositional matrix adjust. Identities = 931/934 (99%), Positives = 933/934 (99%), Gaps = 0/934 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP Sbjct 1 MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVF EITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPRIPVKRMVFPEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA Sbjct 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART Sbjct 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY Sbjct 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG Sbjct 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR Sbjct 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG Sbjct 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLERLVAGDTGEPTPQRANLS+SITPDELTLQVAEELFATPQQGRTLGLDPETGHE Sbjct 661 KNGPYLERLVAGDTGEPTPQRANLSESITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA Sbjct 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 Query 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE Sbjct 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 Query 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER Sbjct 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 Query 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD Sbjct 901 AAELLADRRARGPAKRPARKAARKVPAKKAAKRD 934 >gi|183985106|ref|YP_001853397.1| DNA topoisomerase I TopA [Mycobacterium marinum M] gi|183178432|gb|ACC43542.1| DNA topoisomerase I TopA [Mycobacterium marinum M] Length=934 Score = 1621 bits (4197), Expect = 0.0, Method: Compositional matrix adjust. Identities = 809/936 (87%), Positives = 856/936 (92%), Gaps = 6/936 (0%) Query 1 LADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 +ADPKTKG GS +G LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct 1 MADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 Query 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VSEL+ LLKDVDELYLATDGDREGE Sbjct 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGE 120 Query 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 Query 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 Query 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 Query 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 Query 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 Query 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 Query 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 Query 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 Query 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 Query 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 Query 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 GHEIVA++GR+GPYVTEILPEP A A KK +KA GPKPR+GSLLRSMDLQT+TL Sbjct 718 GHEIVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKTKKATGPKPRSGSLLRSMDLQTITL 777 Query 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 Query 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 Query 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 >gi|240173037|ref|ZP_04751695.1| DNA topoisomerase I [Mycobacterium kansasii ATCC 12478] Length=931 Score = 1617 bits (4187), Expect = 0.0, Method: Compositional matrix adjust. Identities = 818/937 (88%), Positives = 866/937 (93%), Gaps = 11/937 (1%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +A+P++K R SG NG GRRLVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+DVP Sbjct 1 MAEPRSKRRDSG-NGGGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVP 59 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKS+PWARLGVNVDADFEPLYIISPEK+STVSEL+GLLKDVDELYLATDGDREGEAIA Sbjct 60 AKYKSEPWARLGVNVDADFEPLYIISPEKKSTVSELKGLLKDVDELYLATDGDREGEAIA 119 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVFHEITEPAI AA +PR+LDIDLVDAQETRRI+DRLYGYEVSP Sbjct 120 WHLLETLKPRIPVKRMVFHEITEPAILEAAANPRELDIDLVDAQETRRIMDRLYGYEVSP 179 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIV RERDRMAFRSA+YWDI+A LDASVSDP A PPTF+ Sbjct 180 VLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVATLDASVSDPKAQPPTFA 239 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKG----DEVIVLDEGSATALAAGLDGTQLTVASAEE 296 ARLT+VAGRRVA GRDFDSLG LRKG EV VLDE +ATALAA L G +LTVASAEE Sbjct 240 ARLTSVAGRRVAIGRDFDSLGALRKGASPSPEVTVLDEATATALAARLHGARLTVASAEE 299 Query 297 KPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAIN 356 KPY RRPYPPFMTSTLQQEA RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAIN Sbjct 300 KPYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAIN 359 Query 357 AARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDD 416 AARTQARQLYG+EYVA APRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELD D+ Sbjct 360 AARTQARQLYGEEYVAAAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDS---DE 416 Query 417 FRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVD 476 FRLYEL+WQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVD Sbjct 417 FRLYELVWQRTVASQMADARGTTLSLRIAGTAGDQDVVFSASGRTLTFPGFLKAYVETVD 476 Query 477 ELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPST 536 ELVGGEADDAERRLPHLTPGQRLD +ELTPDGHATNPP RYTEASLVKALEELGIGRPST Sbjct 477 ELVGGEADDAERRLPHLTPGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPST 536 Query 537 YSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAG 596 YSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELD IAAG Sbjct 537 YSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIAAG 596 Query 597 NERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIY 656 ERRTNWLNNFYFGG+HGV DSVARSGGLKKLVGINLEGIDAREVNSIKLFDD GRP+Y Sbjct 597 TERRTNWLNNFYFGGEHGVADSVARSGGLKKLVGINLEGIDAREVNSIKLFDDAIGRPVY 656 Query 657 VRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPE 716 VRVGKNGPYLER V GD GEP PQRANL DS+TPDELTL++AE+LFATPQ+GR LG+DP+ Sbjct 657 VRVGKNGPYLERTVTGDNGEPAPQRANLDDSLTPDELTLEIAEQLFATPQEGRVLGVDPQ 716 Query 717 TGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVT 776 TGHEIVA++GR+GPYVTE+LPEPAA+ + + KK +K+ KPRTGSLLRSMDLQTVT Sbjct 717 TGHEIVAKDGRYGPYVTEVLPEPAAE---SGEPAKKAKKSTAAKPRTGSLLRSMDLQTVT 773 Query 777 LEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALK 836 LEDAL+LLSLPRVVGVDP SGEEITAQNGRYGPYLKRG DSRSL TEDQIFTITLDEALK Sbjct 774 LEDALKLLSLPRVVGVDPDSGEEITAQNGRYGPYLKRGKDSRSLATEDQIFTITLDEALK 833 Query 837 IYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASI 896 IYA+PKR GRQSASAPPLRELGTDPASG PMVIKDGRFGPYVTDGETNASLRKGDDVA+I Sbjct 834 IYAQPKRLGRQSASAPPLRELGTDPASGNPMVIKDGRFGPYVTDGETNASLRKGDDVATI 893 Query 897 TDERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 TD+RAAELLADRRARGP KR A+K RK PA+KA KR Sbjct 894 TDQRAAELLADRRARGPVKRTAKKTTRKAPARKAVKR 930 >gi|254821836|ref|ZP_05226837.1| DNA topoisomerase I [Mycobacterium intracellulare ATCC 13950] Length=937 Score = 1606 bits (4159), Expect = 0.0, Method: Compositional matrix adjust. Identities = 803/924 (87%), Positives = 852/924 (93%), Gaps = 4/924 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPK K GGNGS RRLVIVESPTKARKLA YLGS YIVESSRGHIRDLPRAA+DVP Sbjct 1 MADPKLKDSAGGGNGSRRRLVIVESPTKARKLAGYLGSSYIVESSRGHIRDLPRAAADVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKS+PWARLGVNVD DFEPLYIISPEK+STV+EL+GLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSEPWARLGVNVDHDFEPLYIISPEKKSTVTELKGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKP IPVKRMVFHEITEPAI AAE+PRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIV RERDRMAFRSA+YWDI+A+LDASVSDP A+PPTFS Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFS 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLT V G RVATGRDFDSLG LRK DEV +LDE SAT LAAGL G QL+VAS EEKPY Sbjct 241 ARLTNVDGLRVATGRDFDSLGQLRKADEVTILDEASATELAAGLRGAQLSVASVEEKPYT 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPY PFMTSTLQQEA RKLRFS+ERTMSIAQRLYENGYITYMRTDSTTLS+SAINAAR Sbjct 301 RRPYAPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAINAARN 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYG+EYV+P+PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+FRLY Sbjct 361 QARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEFRLY 417 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARG TLSLRI G SG ++VVFSA+GRT+TFPGFLKAYVETVDEL G Sbjct 418 ELIWQRTVASQMADARGTTLSLRIGGRSGERQVVFSASGRTITFPGFLKAYVETVDELAG 477 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAE RLP LT GQRLD +ELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 478 GEADDAESRLPQLTQGQRLDAIELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 537 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELD IA+G ERR Sbjct 538 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERR 597 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 T+WLNNFYFGG+HGV DSVARSGGLKKLVG+NLEGIDAREVNSIKLFDD GRP+YVRVG Sbjct 598 TDWLNNFYFGGEHGVADSVARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVG 657 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLER+V GD GE TPQRANL+DS+TPDELTL++AE+LFATPQ+GR LG+DP TGHE Sbjct 658 KNGPYLERMVTGDDGERTPQRANLNDSLTPDELTLELAEQLFATPQEGRVLGVDPATGHE 717 Query 721 IVAREGRFGPYVTEILPE-PAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLED 779 IVA++GR+GPYV E+LPE P D A KK +K GPKPRTGSLLR+MDLQTVTLED Sbjct 718 IVAKDGRYGPYVAEVLPEPPPGDDDGGATPAKKGKKPTGPKPRTGSLLRTMDLQTVTLED 777 Query 780 ALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYA 839 ALRLLSLPRVVGVDP SGEEITAQNGRYGPYLKRG DSRSL TE+Q+F ITL+EALKIYA Sbjct 778 ALRLLSLPRVVGVDPESGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYA 837 Query 840 EPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDE 899 EPKRRGRQ A+APPLRELG DPA+GKPMVIKDGRFGPYVTDGETNASLRKGDDV SITDE Sbjct 838 EPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDE 897 Query 900 RAAELLADRRARGPAKRPARKAAR 923 RAAELLADRRARGPAKRPA+KAAR Sbjct 898 RAAELLADRRARGPAKRPAKKAAR 921 >gi|118619392|ref|YP_907724.1| DNA topoisomerase I [Mycobacterium ulcerans Agy99] gi|118571502|gb|ABL06253.1| DNA topoisomerase I TopA [Mycobacterium ulcerans Agy99] Length=934 Score = 1604 bits (4154), Expect = 0.0, Method: Compositional matrix adjust. Identities = 803/936 (86%), Positives = 850/936 (91%), Gaps = 6/936 (0%) Query 1 LADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 +ADPKTKG GS +G LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct 1 MADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 Query 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VSEL+ LLKDVDELYLATDGDREGE Sbjct 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGE 120 Query 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 Query 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFR A+YWDI+A LDASVSDP AAPP Sbjct 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRRASYWDIVATLDASVSDPKAAPP 240 Query 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 Query 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 Query 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 Query 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSL I G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct 418 RLYELIWQRTVASQMADARGTTLSLWIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 Query 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNP ARYTEASLVKA EELGIGRPSTY Sbjct 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPLARYTEASLVKAFEELGIGRPSTY 537 Query 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 Query 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 Query 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+D E+ Sbjct 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDAES 717 Query 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 GHEIVA++GR+GPYVTEILPEP A A KK +KA PKPR+GSLLRSMDLQT+TL Sbjct 718 GHEIVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKSKKATAPKPRSGSLLRSMDLQTITL 777 Query 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 Query 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGK MVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct 838 YAEPKRSGRQSASAPPLRELGTDAASGKAMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 Query 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 >gi|118463766|ref|YP_879799.1| DNA topoisomerase I [Mycobacterium avium 104] gi|254773487|ref|ZP_05215003.1| DNA topoisomerase I [Mycobacterium avium subsp. avium ATCC 25291] gi|118165053|gb|ABK65950.1| DNA topoisomerase I [Mycobacterium avium 104] Length=932 Score = 1593 bits (4126), Expect = 0.0, Method: Compositional matrix adjust. Identities = 799/924 (87%), Positives = 852/924 (93%), Gaps = 4/924 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPK K SGGNGS RRLVIVESPTKARKLASYLGS YIVESSRGHIRDLPRAA+DVP Sbjct 1 MADPKLKENTSGGNGSRRRLVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKS+PWARLGVNVDADFEPLYIISPEK+ TVSEL+GLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKP IPVKRMVFHEITEPAI AAE+PRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIV RERDRMAFRSA+YWDI+A+LDASVSDP A+PPTF+ Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFA 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLT+V G RVATGRDFDS G LRK DEVIVLDE AT LAAGL G QL+VAS EEKPY Sbjct 241 ARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEKPYT 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPY PFMTSTLQQEA RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLS SAINAART Sbjct 301 RRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYG+EYV+P+PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+FRLY Sbjct 361 QARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEFRLY 417 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARG TLSLRI G +G ++VVFSA+GRT+TFPGFLKAYVETVDEL G Sbjct 418 ELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFPGFLKAYVETVDELAG 477 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAE RLP LT GQRLD +ELTPDGHATNPP RYTEASLVKALEELGIGRPSTYSSI Sbjct 478 GEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSI 537 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELD IA+G ERR Sbjct 538 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERR 597 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 T+WLNNFYFGG+HGV DS+ARSGGLKKLVG+NLEGIDAREVNSIKLFDD GRP+YVRVG Sbjct 598 TDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVG 657 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLER+V GD GEPTPQRANL+DS+TPDELTL+VAE+LFATPQ+GR LG+DP TGHE Sbjct 658 KNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHE 717 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQG-VKKRQKAAGPKPRTGSLLRSMDLQTVTLED 779 IVA++GR+GPYV E+LPEP D + KK +K GPKPRT SLLR+MDLQTVTLED Sbjct 718 IVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLED 777 Query 780 ALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYA 839 ALRLLSLPRVVGVDP +GEEITAQNGRYGPYLKRGNDSRSL TE+Q+F ITL+EALKIYA Sbjct 778 ALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLATEEQLFDITLEEALKIYA 837 Query 840 EPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDE 899 EPKRRGRQ A+APPLRELG DPA+GKPMVIKDGRFGPYVTDGETNASLRKGDDV S+TD+ Sbjct 838 EPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQ 897 Query 900 RAAELLADRRARGPAKRPARKAAR 923 RAAELLADRRARGPAKR A+K +R Sbjct 898 RAAELLADRRARGPAKRTAKKTSR 921 >gi|41406523|ref|NP_959359.1| DNA topoisomerase I [Mycobacterium avium subsp. paratuberculosis K-10] gi|41394872|gb|AAS02742.1| TopA [Mycobacterium avium subsp. paratuberculosis K-10] Length=932 Score = 1589 bits (4115), Expect = 0.0, Method: Compositional matrix adjust. Identities = 796/924 (87%), Positives = 851/924 (93%), Gaps = 4/924 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPK K SGGNGS RRLVIVESPTKARKLASYLGS YIVESSRGHIRDLPRAA+DVP Sbjct 1 MADPKLKENTSGGNGSRRRLVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKS+PWARLGVNVDADFEPLYIISPEK+ TVSEL+GLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKP IPVKRMVFHEITEPAI AAE+PRDLDIDLVDAQETRRILDRLYGYEV+P Sbjct 121 WHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVTP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIV RERDRMAFRSA+YWDI+A+LDASVSDP A+PPTF+ Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFA 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLT+V G RVATGRDFDS G LRK DEVIVLDE AT LAAGL G QL+VAS EEKPY Sbjct 241 ARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEKPYT 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPY PFMTSTLQQEA RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLS SAINAART Sbjct 301 RRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYG+EYV+P+PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+FRLY Sbjct 361 QARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEFRLY 417 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARG TLSLRI G +G ++VVFSA+GRT+TF GFLKAYVETVDEL G Sbjct 418 ELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFAGFLKAYVETVDELAG 477 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAE RLP LT GQRLD +ELTPDGHATNPP RYTEASLVKALEELGIGRPSTYSSI Sbjct 478 GEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSI 537 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELD IA+G ERR Sbjct 538 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERR 597 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 T+WLNNFYFGG+HGV DS+ARSGGLKKLVG+NLEGIDAREVNSIKLFDD GRP+YVRVG Sbjct 598 TDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVG 657 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLER+V GD GEPTPQRANL+DS+TPDELTL+VAE+LFATPQ+GR LG+DP TGHE Sbjct 658 KNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHE 717 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQG-VKKRQKAAGPKPRTGSLLRSMDLQTVTLED 779 IVA++GR+GPYV E+LPEP D + KK +K GPKPRT SLLR+MDLQTVTLED Sbjct 718 IVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLED 777 Query 780 ALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYA 839 ALRLLSLPRVVGVDP +GEEITAQNGRYGPYLKRGNDSRSL +E+Q+F ITL+EALKIYA Sbjct 778 ALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLASEEQLFDITLEEALKIYA 837 Query 840 EPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDE 899 EPKRRGRQ A+APPLRELG DPA+GKPMVIKDGRFGPYVTDGETNASLRKGDDV S+TD+ Sbjct 838 EPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQ 897 Query 900 RAAELLADRRARGPAKRPARKAAR 923 RAAELLADRRARGPAKR A+K +R Sbjct 898 RAAELLADRRARGPAKRTAKKTSR 921 >gi|296166702|ref|ZP_06849127.1| DNA topoisomerase TopA [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295897967|gb|EFG77548.1| DNA topoisomerase TopA [Mycobacterium parascrofulaceum ATCC BAA-614] Length=930 Score = 1583 bits (4099), Expect = 0.0, Method: Compositional matrix adjust. Identities = 789/913 (87%), Positives = 837/913 (92%), Gaps = 4/913 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 + DP K R SG GS RRLVIVESPTKARKLA YLGS YIVESSRGHIRDLPRAA+DVP Sbjct 1 MGDPNLKDRESGRTGSRRRLVIVESPTKARKLAGYLGSNYIVESSRGHIRDLPRAAADVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKS+PWARLGVNVD DFEPLYIISPEK+STVSEL+GLLK VDELYLATDGDREGEAIA Sbjct 61 AKYKSEPWARLGVNVDHDFEPLYIISPEKKSTVSELKGLLKGVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKP IPVKRMVFHEITEPAI AAE+PRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIV RERDRMAFRSA+YWDI+A+LDASVSDP AAPPTF+ Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQAAPPTFT 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLT V G RVATGRDFDSLG LRK DEV VL+E AT LAAGL G QL+VAS EEKPY Sbjct 241 ARLTGVDGLRVATGRDFDSLGQLRKADEVTVLNEAQATELAAGLRGAQLSVASVEEKPYT 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPY PFMTSTLQQEA RKLRFS+ERTMSIAQRLYENGYITYMRTDSTTLS+SAINAART Sbjct 301 RRPYAPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYG+EYV+P+PRQYTRKVKNAQEAHEAIRPAGE FATPDAVRRELDG D+FRLY Sbjct 361 QARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGEAFATPDAVRRELDG---DEFRLY 417 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARG TLSLRI G +G +EVVFSA+GRT+TF GFLKAYVETVDEL G Sbjct 418 ELIWQRTVASQMADARGTTLSLRINGATGDREVVFSASGRTITFAGFLKAYVETVDELAG 477 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAE RLP LT GQRLD V+LTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 478 GEADDAESRLPQLTRGQRLDAVDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 537 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDY FTAAMEDELD IA+G ERR Sbjct 538 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYGFTAAMEDELDAIASGQERR 597 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 T+WLN FYFGGDHGV DSVARSGGLKKLVG+NLEGIDAREVNSIKLFDD GRP+YVRVG Sbjct 598 TDWLNRFYFGGDHGVADSVARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVG 657 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLER+VAGD GEPTPQRANL+DS+TPDELTL+VAE+LFATPQ+GR+LG+DP+TGHE Sbjct 658 KNGPYLERMVAGDEGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRSLGVDPQTGHE 717 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 IVA++GR+GPYVTE+LP P + A K ++ KPRTGSLLRSMDLQTVTLEDA Sbjct 718 IVAKDGRYGPYVTEVLPPPPNEEEGGAPAKKGKKPTGP-KPRTGSLLRSMDLQTVTLEDA 776 Query 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 L+LLSLPRVVGVDP +GEEITAQNGRYGPYLKRG DSRSL TEDQIF ITLDEALKIYAE Sbjct 777 LKLLSLPRVVGVDPQTGEEITAQNGRYGPYLKRGTDSRSLATEDQIFEITLDEALKIYAE 836 Query 841 PKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDER 900 PKRRGRQ+A+APPLRELG DPA+GKPMVIKDGRFGPYVTDGETNASLRKGDDV SITDER Sbjct 837 PKRRGRQAAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDER 896 Query 901 AAELLADRRARGP 913 AAELLADRRARGP Sbjct 897 AAELLADRRARGP 909 >gi|1395205|gb|AAC44599.1| topoisomerase I [Mycobacterium tuberculosis] Length=900 Score = 1582 bits (4097), Expect = 0.0, Method: Compositional matrix adjust. Identities = 814/852 (96%), Positives = 817/852 (96%), Gaps = 1/852 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDL R Sbjct 7 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDL-RGPRRCT 65 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 KYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA Sbjct 66 RKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 125 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 126 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 185 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS Sbjct 186 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 245 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLTAVAGRRVATG K + + G+ AGLDGTQLTVASAEEKPYA Sbjct 246 ARLTAVAGRRVATGAISTRWARCAKATKSLCSTRGARPRWPAGLDGTQLTVASAEEKPYA 305 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART Sbjct 306 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 365 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYGD PAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY Sbjct 366 QARQLYGDGVRRPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 425 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG Sbjct 426 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 485 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 486 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 545 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR Sbjct 546 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 605 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG Sbjct 606 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 665 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE Sbjct 666 KNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 725 Query 721 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 780 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA Sbjct 726 IVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDA 785 Query 781 LRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 840 LRLLSLPRVVGVDPAS EEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE Sbjct 786 LRLLSLPRVVGVDPASVEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAE 845 Query 841 PKRRGRQSASAP 852 PKRRGRQSASAP Sbjct 846 PKRRGRQSASAP 857 Score = 77.4 bits (189), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 67/236 (29%), Positives = 106/236 (45%), Gaps = 59/236 (25%) Query 713 LDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDL 772 D G I R G+ GPY+ ++ A D P P+ +L S+ Sbjct 652 FDDTHGRPIYVRVGKNGPYLERLV---AGDTGE-------------PTPQRANLSDSITP 695 Query 773 QTVTLEDALRLLSLP---RVVGVDPASGEEITAQNGRYGPYL--------------KRGN 815 +TL+ A L + P R +G+DP +G EI A+ GR+GPY+ +G Sbjct 696 DELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGV 755 Query 816 DSR-----------SLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASG 864 R SL+ + T+TL++AL++ + P R +G DPAS Sbjct 756 KKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLP-------------RVVGVDPASV 802 Query 865 KPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLAD--RRARGPAKRPA 918 + + ++GR+GPY+ G + SL D + +IT + A ++ A+ RR R A PA Sbjct 803 EEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPA 858 >gi|15827005|ref|NP_301268.1| DNA topoisomerase I [Mycobacterium leprae TN] gi|221229483|ref|YP_002502899.1| DNA topoisomerase I [Mycobacterium leprae Br4923] gi|6226246|sp|O69548.1|TOP1_MYCLE RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme gi|3097241|emb|CAA18818.1| DNA topoisomerase I [Mycobacterium leprae] gi|13092552|emb|CAC29708.1| putative DNA topoisomerase I [Mycobacterium leprae] gi|219932590|emb|CAR70293.1| putative DNA topoisomerase I [Mycobacterium leprae Br4923] Length=947 Score = 1581 bits (4093), Expect = 0.0, Method: Compositional matrix adjust. Identities = 792/935 (85%), Positives = 850/935 (91%), Gaps = 13/935 (1%) Query 7 KGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQ 66 +G SG NGS RRLVIVESPTKARKL+ YLGS YIVESSRGHIRDLPR A+DVPAK+KS+ Sbjct 5 RGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSE 64 Query 67 PWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLET 126 PWARLGVNVDADFEPLYII+PEK+STV+EL+GLL+ VDELYLATDGDREGEAIAWHL++T Sbjct 65 PWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQT 124 Query 127 LKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKV 186 LKPR+PVKRMVFHEITE AI AAA HPR+LDIDLVDAQETRRILDRLYGYEVSPVLWKKV Sbjct 125 LKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKV 184 Query 187 APKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAV 246 APKLSAGRVQSVATRIIV RERDRMAF SA YWDI+AKLDASVSDP A P TF ARLTAV Sbjct 185 APKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAV 244 Query 247 AGRRVATGRDFDSLGTLRKGDEV---IVLDEGSATALAAGLDGTQLTVASAEEKPYARRP 303 G RVATGRDF ++GTLR EV IVLD+ +AT LAAGL G QLTVASAEEK Y RRP Sbjct 245 DGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRP 304 Query 304 YPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQAR 363 YPPFMTSTLQQEA RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQAR Sbjct 305 YPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQAR 364 Query 364 QLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELI 423 QLYG+EYV+ +PRQYTRKVKNAQEAHEAIRPAGETFATPDAV ELDG D+FR+YEL+ Sbjct 365 QLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDG---DEFRIYELV 421 Query 424 WQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEA 483 W+RTVASQMADARG TLSLRI G +G Q VVFSA+GRTLTFPGFLKAYVETVDEL GGEA Sbjct 422 WRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEA 481 Query 484 DDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKT 543 DDAERRLPHLT GQ LD+++LTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKT Sbjct 482 DDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKT 541 Query 544 IQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNW 603 +QDRGYV KKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIA GNE+RTNW Sbjct 542 VQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNW 601 Query 604 LNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNG 663 LNNFYFGG+HGV DS+ARSGGLKKLVG+N+EGIDAREVNSIKLFDD HGRP+YVRVGK G Sbjct 602 LNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTG 661 Query 664 PYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVA 723 PYLERL+AGD GE TPQRANL+ ++TPDELTL+VAEELFATP +GR LG+DPETGHEIVA Sbjct 662 PYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVA 721 Query 724 REGRFGPYVTEILPEPAADAAAAAQGVKKRQK------AAGPKPRTGSLLRSMDLQTVTL 777 ++GR+GPYVTE+LP+ D AA QG KK +K + GPKPRTGSLLRSMDLQT+TL Sbjct 722 KDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITL 781 Query 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 EDAL+LL LPRVVGVDPASGEEITAQNGRYGPYLKRG DSR L TEDQ+F ITLDEALKI Sbjct 782 EDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKI 841 Query 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 YAEPKR GRQS S PPLRELGTDP SGKPM+IKDGRFGPYVTDGETNASLRKGDDV SIT Sbjct 842 YAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSIT 901 Query 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAK 932 DERAAELLADRRARGP KRPA+K ARKVPAKKAA+ Sbjct 902 DERAAELLADRRARGPVKRPAKK-ARKVPAKKAAR 935 >gi|342862017|ref|ZP_08718661.1| DNA topoisomerase I subunit omega [Mycobacterium colombiense CECT 3035] gi|342130557|gb|EGT83866.1| DNA topoisomerase I subunit omega [Mycobacterium colombiense CECT 3035] Length=917 Score = 1570 bits (4065), Expect = 0.0, Method: Compositional matrix adjust. Identities = 784/900 (88%), Positives = 834/900 (93%), Gaps = 8/900 (0%) Query 21 VIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFE 80 +IVESPTKARKLASYLGS YIVESSRGHIRDLPRAA+DVPAK+KS+PWARLGVNVDADFE Sbjct 1 MIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFE 60 Query 81 PLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHE 140 PLYIISPEK+STV+EL+GLLK+VDELYLATDGDREGEAIAWHLLETLKP IPVKRMVFHE Sbjct 61 PLYIISPEKKSTVTELKGLLKEVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVFHE 120 Query 141 ITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVAT 200 ITEPAI AAE+PRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVAT Sbjct 121 ITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVAT 180 Query 201 RIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSL 260 RIIV RERDRMAFRSA+YWDILAKLDASVSDP A+PPTF+ARLT V G RVA GRDFDSL Sbjct 181 RIIVQRERDRMAFRSASYWDILAKLDASVSDPQASPPTFTARLTGVDGLRVAAGRDFDSL 240 Query 261 GTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKL 320 G LRK +EV +LDE SAT LAAGL G QLTVAS EEKPY RRPY PFMTSTLQQEA RKL Sbjct 241 GQLRKANEVTILDEASATQLAAGLSGAQLTVASVEEKPYTRRPYAPFMTSTLQQEAGRKL 300 Query 321 RFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTR 380 RFS+ERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYG EYV+P+PRQYTR Sbjct 301 RFSSERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGAEYVSPSPRQYTR 360 Query 381 KVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTL 440 KVKNAQEAHEAIRPAGETFATPDAVRRELDG D+FR+YELIWQRTVASQMADARG TL Sbjct 361 KVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEFRIYELIWQRTVASQMADARGTTL 417 Query 441 SLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLD 500 SLRI G S ++VVFSA+GRT+TF GFLKAYVETVDEL GGEADDAE RLP LT GQRLD Sbjct 418 SLRINGQSAGRDVVFSASGRTITFAGFLKAYVETVDELAGGEADDAESRLPQLTQGQRLD 477 Query 501 IVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPS 560 +ELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPS Sbjct 478 ALELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPS 537 Query 561 WVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVA 620 WVAFAVTGLLEQHFGRLVDYDFTAAMEDELD IA+G ERRT+WLNNFYFGG+HGV DSVA Sbjct 538 WVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSVA 597 Query 621 RSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQ 680 RSGGLKKLVG+NLEGIDAREVNSI+LFDD GRP+YVRVGKNGPYLER+V GD GEP PQ Sbjct 598 RSGGLKKLVGVNLEGIDAREVNSIRLFDDEQGRPVYVRVGKNGPYLERMVTGDDGEPKPQ 657 Query 681 RANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEP- 739 RANL+DS+TPDELTL+VAE+LFATPQ+GR LG+DP TGHEIVA++GR+GPYV+E+LPEP Sbjct 658 RANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIVAKDGRYGPYVSEVLPEPP 717 Query 740 --AADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASG 797 D +A A KK +K GPKPRTGSLLR+MDLQTVTLEDALRLLSLPRVVGVDP +G Sbjct 718 PGGDDGSATA--AKKGKKPTGPKPRTGSLLRTMDLQTVTLEDALRLLSLPRVVGVDPETG 775 Query 798 EEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLREL 857 EEITAQNGRYGPYLKRG DSRSL TE+Q+F ITL+EALKIYAEPKRRGRQ A+APPLREL Sbjct 776 EEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAAAPPLREL 835 Query 858 GTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRP 917 G DPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGP KRP Sbjct 836 GADPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPVKRP 895 >gi|336460892|gb|EGO39776.1| DNA topoisomerase I, bacterial [Mycobacterium avium subsp. paratuberculosis S397] Length=912 Score = 1560 bits (4040), Expect = 0.0, Method: Compositional matrix adjust. Identities = 782/904 (87%), Positives = 835/904 (93%), Gaps = 4/904 (0%) Query 21 VIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFE 80 +IVESPTKARKLASYLGS YIVESSRGHIRDLPRAA+DVPAKYKS+PWARLGVNVDADFE Sbjct 1 MIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFE 60 Query 81 PLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHE 140 PLYIISPEK+ TVSEL+GLLKDVDELYLATDGDREGEAIAWHLLETLKP IPVKRMVFHE Sbjct 61 PLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVFHE 120 Query 141 ITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVAT 200 ITEPAI AAE+PRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVAT Sbjct 121 ITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVAT 180 Query 201 RIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSL 260 RIIV RERDRMAFRSA+YWDI+A+LDASVSDP A+PPTF+ARLT+V G RVATGRDFDS Sbjct 181 RIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFAARLTSVDGLRVATGRDFDSQ 240 Query 261 GTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKL 320 G LRK DEVIVLDE AT LAAGL G QL+VAS EEKPY RRPY PFMTSTLQQEA RKL Sbjct 241 GQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEKPYTRRPYAPFMTSTLQQEAGRKL 300 Query 321 RFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTR 380 RFSAERTMSIAQRLYENGYITYMRTDSTTLS SAINAARTQARQLYG+EYV+P+PRQYTR Sbjct 301 RFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINAARTQARQLYGEEYVSPSPRQYTR 360 Query 381 KVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTL 440 KVKNAQEAHEAIRPAGETFATPDAVRRELDG D+FRLYELIWQRTVASQMADARG TL Sbjct 361 KVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEFRLYELIWQRTVASQMADARGTTL 417 Query 441 SLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLD 500 SLRI G +G ++VVFSA+GRT+TF GFLKAYVETVDEL GGEADDAE RLP LT GQRLD Sbjct 418 SLRIGGQAGDRQVVFSASGRTITFAGFLKAYVETVDELAGGEADDAESRLPQLTQGQRLD 477 Query 501 IVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPS 560 ELTPDGHATNPP RYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPS Sbjct 478 ATELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPS 537 Query 561 WVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVA 620 WVAFAVTGLLEQHFGRLVDYDFTAAMEDELD IA+G ERRT+WLNNFYFGG+HGV DS+A Sbjct 538 WVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSIA 597 Query 621 RSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQ 680 RSGGLKKLVG+NLEGIDAREVNSIKLFDD GRP+YVRVGKNGPYLER+V GD GEPTPQ Sbjct 598 RSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDDGEPTPQ 657 Query 681 RANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPA 740 RANL+DS+TPDELTL+VAE+LFATPQ+GR LG+DP TGHEIVA++GR+GPYV E+LPEP Sbjct 658 RANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIVAKDGRYGPYVAEVLPEPP 717 Query 741 ADAAAAAQG-VKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEE 799 D + KK +K GPKPRT SLLR+MDLQTVTLEDALRLLSLPRVVGVDP +GEE Sbjct 718 PDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLEDALRLLSLPRVVGVDPETGEE 777 Query 800 ITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGT 859 ITAQNGRYGPYLKRGNDSRSL +E+Q+F ITL+EALKIYAEPKRRGRQ A+APPLRELG Sbjct 778 ITAQNGRYGPYLKRGNDSRSLASEEQLFDITLEEALKIYAEPKRRGRQGAAAPPLRELGA 837 Query 860 DPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPAR 919 DPA+GKPMVIKDGRFGPYVTDGETNASLRKGDDV S+TD+RAAELLADRRARGPAKR A+ Sbjct 838 DPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQRAAELLADRRARGPAKRTAK 897 Query 920 KAAR 923 K +R Sbjct 898 KTSR 901 >gi|333992571|ref|YP_004525185.1| DNA topoisomerase I TopA [Mycobacterium sp. JDM601] gi|333488539|gb|AEF37931.1| DNA topoisomerase I TopA [Mycobacterium sp. JDM601] Length=912 Score = 1512 bits (3915), Expect = 0.0, Method: Compositional matrix adjust. Identities = 767/917 (84%), Positives = 834/917 (91%), Gaps = 7/917 (0%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKARK+A YLGSGY+VESSRGHIRDLPR A DVPAKYK++PWARLGVNVDA Sbjct 2 RRLVIVESPTKARKIAGYLGSGYVVESSRGHIRDLPRNAGDVPAKYKTEPWARLGVNVDA 61 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 +FEPLYI+SP+K+STV+EL+GLLKDVDELYLATDGDREGEAIAWHLLETLKPR+PVKRMV Sbjct 62 EFEPLYIVSPDKKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMV 121 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITEPAIR AAE+PRDLDIDLVDAQETRR+LDRLYGYEVSPVLWKKVAPKLSAGRVQS Sbjct 122 FHEITEPAIRNAAENPRDLDIDLVDAQETRRVLDRLYGYEVSPVLWKKVAPKLSAGRVQS 181 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATRIIV RER+RMAFRSA+YWD++A+LDASVSDP AAPPTF+ARL AV RVA+GRDF Sbjct 182 VATRIIVQRERERMAFRSASYWDVVAQLDASVSDPGAAPPTFTARLVAVDELRVASGRDF 241 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 DSLGTLRK DEV VLDE +ATALAAGL G L+V S EEKPY RRPY PFMTSTLQQEA Sbjct 242 DSLGTLRKPDEVRVLDEAAATALAAGLAGASLSVTSVEEKPYTRRPYAPFMTSTLQQEAG 301 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLS SAI+AARTQARQLYG+EYV+P PRQ Sbjct 302 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSASAIDAARTQARQLYGEEYVSPTPRQ 361 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 YTRKVKNAQEAHEAIRPAGETFATPDAVR EL D+FRLYELIWQRTVASQMADARG Sbjct 362 YTRKVKNAQEAHEAIRPAGETFATPDAVRNELGS---DEFRLYELIWQRTVASQMADARG 418 Query 438 MTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQ 497 TLSLRI G SG Q+V F+A+GRT+TF GFLKAYVETVDEL GGEADDAERRLP LT GQ Sbjct 419 TTLSLRIGGRSGSQQVTFAASGRTITFAGFLKAYVETVDELAGGEADDAERRLPQLTQGQ 478 Query 498 RLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSAL 557 R+D E TPDGH+TNPPARYTEASLVK+LEELGIGRPSTYSSIIKTIQDRGYV+KKGSAL Sbjct 479 RVDAAEATPDGHSTNPPARYTEASLVKSLEELGIGRPSTYSSIIKTIQDRGYVYKKGSAL 538 Query 558 VPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPD 617 VP+WVAFAV GLLEQHFGRLVDYDFTAAMEDELD IAAG +RRT+WL+NFYFGGD+GV Sbjct 539 VPTWVAFAVIGLLEQHFGRLVDYDFTAAMEDELDGIAAGRQRRTDWLHNFYFGGDYGVEG 598 Query 618 SVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEP 677 S+AR+GGLKKLVG+NLEGIDARE+NSIKLFDD GRP+YVRVGKNGPYLER+VAGD GEP Sbjct 599 SIARAGGLKKLVGVNLEGIDAREINSIKLFDDEQGRPVYVRVGKNGPYLERMVAGDDGEP 658 Query 678 TPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILP 737 TPQRANL DS+ PDELTL +AEE FATPQ+GR LG+DPETGHEIVA++GR+GPYVTEILP Sbjct 659 TPQRANLDDSLPPDELTLALAEERFATPQEGRPLGIDPETGHEIVAKDGRYGPYVTEILP 718 Query 738 EPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASG 797 P ++ A+ KK RTGSLLRSMDLQTVTLEDAL+LLSLPRVVGVDP SG Sbjct 719 PPDDESGTTAKKGKKPTGPKP---RTGSLLRSMDLQTVTLEDALKLLSLPRVVGVDPGSG 775 Query 798 EEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLREL 857 +EITAQNGRYGPYLKRG DSRSL +E+QIF ITL+EALKIYAEPKRRGRQ+A+APPLREL Sbjct 776 DEITAQNGRYGPYLKRGTDSRSLSSEEQIFEITLEEALKIYAEPKRRGRQAAAAPPLREL 835 Query 858 GTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPA-KR 916 G DPA+GKPMVIKDGRFGPYVTDGETNASLRKGD+VASITDERAAELLADRRA+GP K+ Sbjct 836 GADPATGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERAAELLADRRAKGPVKKK 895 Query 917 PARKAARKVPAKKAAKR 933 A+K RK PAKKA KR Sbjct 896 AAKKTTRKAPAKKATKR 912 >gi|118467403|ref|YP_890377.1| DNA topoisomerase I [Mycobacterium smegmatis str. MC2 155] gi|118168690|gb|ABK69586.1| DNA topoisomerase I [Mycobacterium smegmatis str. MC2 155] Length=936 Score = 1488 bits (3852), Expect = 0.0, Method: Compositional matrix adjust. Identities = 737/901 (82%), Positives = 811/901 (91%), Gaps = 8/901 (0%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKARK+A YLGS Y+VESSRGHIRDLPR A+DVPAK+KS+PWARLGVNVD Sbjct 15 RRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRNAADVPAKFKSEPWARLGVNVDQ 74 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 +FEPLYI+SPEK+STV+EL+GLLKDVDELYLATDGDREGEAIAWHLLETLKPR+PVKRMV Sbjct 75 NFEPLYIVSPEKKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMV 134 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITEPAIR AAE+PRDLDI LVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS Sbjct 135 FHEITEPAIRNAAENPRDLDIALVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 194 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATRIIV RER+RMAF SA+YWD+ A+LDASVSDP A+PP F+A+L V GRRVATGRDF Sbjct 195 VATRIIVQRERERMAFHSASYWDVTAELDASVSDPSASPPKFTAKLNTVDGRRVATGRDF 254 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 DSLG L++ DEV+VLDE SA ALA+GL G QL V S E+KPY RRPY PFMTSTLQQEA+ Sbjct 255 DSLGQLKRPDEVLVLDEASAGALASGLRGAQLAVTSVEQKPYTRRPYAPFMTSTLQQEAA 314 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRFS+ERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYG+EYV P+PRQ Sbjct 315 RKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQ 374 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 YTRKVKNAQEAHEAIRPAG+ F TP + LD D+FRLYELIWQRTVASQMADARG Sbjct 375 YTRKVKNAQEAHEAIRPAGDVFQTPGQLHSALD---TDEFRLYELIWQRTVASQMADARG 431 Query 438 MTLSLRITG-MSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPG 496 TLSLRI G S ++VVF+A+GRT+TFPGFLKAYVE++DEL GGE+DDAE RLP+LT G Sbjct 432 TTLSLRIGGSASSGEQVVFNASGRTITFPGFLKAYVESIDELAGGESDDAESRLPNLTQG 491 Query 497 QRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSA 556 QR+D +L+ DGH T+PPARYTEASL+KALEELGIGRPSTYSSIIKTIQDRGYV KKGSA Sbjct 492 QRVDAADLSADGHQTSPPARYTEASLIKALEELGIGRPSTYSSIIKTIQDRGYVQKKGSA 551 Query 557 LVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVP 616 LVPSWVAFAV GLLEQHFGRLVDYDFTAAMEDELDEIA G E+RTNWLNNFYFGG+HGV Sbjct 552 LVPSWVAFAVVGLLEQHFGRLVDYDFTAAMEDELDEIANGQEQRTNWLNNFYFGGEHGVE 611 Query 617 DSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLV--AGDT 674 S+AR+GGLK+LVG NLEGIDAREVNSIK+FDD+ GRP+YVRVG+NGPYLER+V + Sbjct 612 GSIARAGGLKQLVGGNLEGIDAREVNSIKVFDDSEGRPVYVRVGRNGPYLERMVDDPDNP 671 Query 675 GEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTE 734 GE PQRANL + +TPDELT ++AE+LFATPQ+GR+LG+DPETGHEIVA++GRFGPYVTE Sbjct 672 GEQKPQRANLKEDLTPDELTPELAEKLFATPQEGRSLGIDPETGHEIVAKDGRFGPYVTE 731 Query 735 ILPEP--AADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGV 792 +LPEP D A KK +K GPKPRTGSL RSMDL+TVTLEDAL+LLSLPRVVGV Sbjct 732 VLPEPEDGGDDGTAGTPAKKGKKPTGPKPRTGSLFRSMDLETVTLEDALKLLSLPRVVGV 791 Query 793 DPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAP 852 DP + EEITAQNGRYGPYLKRG DSRSL TEDQIFTITLDEALKIYAEPKRRGRQ+ASAP Sbjct 792 DPTTNEEITAQNGRYGPYLKRGTDSRSLATEDQIFTITLDEALKIYAEPKRRGRQAASAP 851 Query 853 PLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARG 912 PLRELG DP SGKPMVIKDGRFGPYVTDGETNASLRKGDDV +ITDERA+ELLADRRARG Sbjct 852 PLRELGNDPVSGKPMVIKDGRFGPYVTDGETNASLRKGDDVLTITDERASELLADRRARG 911 Query 913 P 913 P Sbjct 912 P 912 >gi|120406344|ref|YP_956173.1| DNA topoisomerase I [Mycobacterium vanbaalenii PYR-1] gi|119959162|gb|ABM16167.1| DNA topoisomerase I [Mycobacterium vanbaalenii PYR-1] Length=955 Score = 1457 bits (3773), Expect = 0.0, Method: Compositional matrix adjust. Identities = 735/925 (80%), Positives = 805/925 (88%), Gaps = 25/925 (2%) Query 9 RGSGGNG---------SGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDV 59 RGSG NG S RRLVIVESPTKARK+A YLGS YIVESSRGHIRDLPR A+DV Sbjct 6 RGSGKNGAEPRRGNGSSVRRLVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRNAADV 65 Query 60 PAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAI 119 PAKYKS+PWARLGVNV+ +FEPLYIISP+K+STV++L+ LK+VDELYLATDGDREGEAI Sbjct 66 PAKYKSEPWARLGVNVEHNFEPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAI 125 Query 120 AWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVS 179 AWHLLETLKPRIPVKRMVFHEITEPAIRAAAE PRDLD DLVDAQETRRILDRLYGYEVS Sbjct 126 AWHLLETLKPRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVS 185 Query 180 PVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTF 239 PVLWKKVAPKLSAGRVQSVATRIIV RER+RMAFRSA YWD+ A+LDASVSD A+PPTF Sbjct 186 PVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQASPPTF 245 Query 240 SARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPY 299 A+L V GRRVATGRDFDSLG +RK DEV+VLDE +A ALA GL G QL V+S E+KPY Sbjct 246 VAKLNTVDGRRVATGRDFDSLGAVRKPDEVLVLDEAAANALATGLRGAQLAVSSVEQKPY 305 Query 300 ARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAAR 359 RRPY PFMTSTLQQEA RKLRF++ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR Sbjct 306 TRRPYAPFMTSTLQQEAGRKLRFTSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAAR 365 Query 360 TQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRL 419 QARQLYG+EYV P PRQYTRKVKNAQEAHEAIRPAG+ F TP + +LD D+FRL Sbjct 366 NQARQLYGEEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSQLD---TDEFRL 422 Query 420 YELIWQRTVASQMADARGMTLSLRIT----------GMSGHQEVVFSATGRTLTFPGFLK 469 YELIWQRTVASQMADARG TLSLRI G + +VVF+A+GRT+TFPGFLK Sbjct 423 YELIWQRTVASQMADARGTTLSLRIAGAAPATTLGGGTASDVQVVFNASGRTITFPGFLK 482 Query 470 AYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEEL 529 AYVE++D+L GGEADDAE RLP+LT GQR+D LT DGH T+PPARYTEASL+KALE+L Sbjct 483 AYVESIDDLAGGEADDAESRLPNLTQGQRVDAKGLTADGHTTSPPARYTEASLIKALEDL 542 Query 530 GIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDE 589 GIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAV GLLEQHFGRLVDYDFTAAMEDE Sbjct 543 GIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFGRLVDYDFTAAMEDE 602 Query 590 LDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDD 649 LDEIAAG+ERRTNWLNNFYFGG+HG S+ARSGGLKKLVG NLE IDAREVNSIKLFDD Sbjct 603 LDEIAAGHERRTNWLNNFYFGGEHGADGSIARSGGLKKLVGGNLEEIDAREVNSIKLFDD 662 Query 650 THGRPIYVRVGKNGPYLERLVA--GDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQ 707 GR + VRVG+NG YLER+VA + GE PQRANL D +TPDELTL++AE+LFATPQ+ Sbjct 663 AEGRAVNVRVGRNGAYLERMVADPDNPGELKPQRANLKDELTPDELTLELAEKLFATPQE 722 Query 708 GRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLL 767 GR+LG+DP TGHEIVA++GR+GPYVTE+LPEP + A A K ++ PKPRTGSLL Sbjct 723 GRSLGVDPATGHEIVAKDGRYGPYVTEVLPEPPDEGEAGATAKKGKKPTG-PKPRTGSLL 781 Query 768 RSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIF 827 RSMDL+TVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG DSRSL TE+Q+F Sbjct 782 RSMDLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGTDSRSLATEEQMF 841 Query 828 TITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASL 887 ITL+EALKIYAEPKRRGRQ A+ PPLRELG DP S KPMVIKDGRFGPYVTDGETNASL Sbjct 842 DITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASL 901 Query 888 RKGDDVASITDERAAELLADRRARG 912 RKGDDV SITD RA+ELLADRRARG Sbjct 902 RKGDDVLSITDARASELLADRRARG 926 >gi|145221986|ref|YP_001132664.1| DNA topoisomerase I [Mycobacterium gilvum PYR-GCK] gi|145214472|gb|ABP43876.1| DNA topoisomerase I [Mycobacterium gilvum PYR-GCK] Length=941 Score = 1455 bits (3766), Expect = 0.0, Method: Compositional matrix adjust. Identities = 735/909 (81%), Positives = 804/909 (89%), Gaps = 9/909 (0%) Query 9 RGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPW 68 RGSG NGS RRLVIVESPTKARK+A YLGS Y+VESSRGHIRDLPRAA+DVPAKYKS+PW Sbjct 6 RGSGKNGSVRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRAAADVPAKYKSEPW 65 Query 69 ARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLK 128 ARLGVNVDADFEPLYIISP+K++TV++L+ LK+VDELYLATDGDREGEAIAWHLLETLK Sbjct 66 ARLGVNVDADFEPLYIISPDKKATVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLK 125 Query 129 PRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP 188 PRIPVKRMVFHEITEPAIRAAAE PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAP Sbjct 126 PRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAP 185 Query 189 KLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAG 248 KLSAGRVQSVATRIIV RER+RMAFRSA YWD+ A+LDASVSD A PPTF A+L V G Sbjct 186 KLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQATPPTFVAKLNTVDG 245 Query 249 RRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFM 308 RRVA GRDFDSLG ++K EV+VLDE +A ALA GL G QL+V+S E+KPY RRPY PFM Sbjct 246 RRVAAGRDFDSLGAVKKPGEVLVLDEAAANALAGGLRGAQLSVSSVEQKPYTRRPYAPFM 305 Query 309 TSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGD 368 TSTLQQEA RKLR S+ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYG+ Sbjct 306 TSTLQQEAGRKLRMSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGE 365 Query 369 EYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTV 428 EYV P PRQYTRKVKNAQEAHEAIRPAG+ F TP + +LD D+FRLYELIWQRTV Sbjct 366 EYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSQLD---TDEFRLYELIWQRTV 422 Query 429 ASQMADARGMTLSLRITG--MSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDA 486 ASQMADARG TLSLRI G SG Q VVF+A+GRT+TF GFLKAYVE++DE GGEADDA Sbjct 423 ASQMADARGTTLSLRIAGAATSGEQ-VVFNASGRTITFAGFLKAYVESLDEQAGGEADDA 481 Query 487 ERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQD 546 E RLP+LT GQR+D +LT DGH T+PPARYTEASL+KALE+LGIGRPSTYSSIIKTIQD Sbjct 482 ESRLPNLTQGQRVDAKDLTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQD 541 Query 547 RGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNN 606 RGYVHKKGSALVPSWVAFAV GLLEQHF RLVDYDFTAAMEDELDEIAAGNERRTNWLNN Sbjct 542 RGYVHKKGSALVPSWVAFAVIGLLEQHFSRLVDYDFTAAMEDELDEIAAGNERRTNWLNN 601 Query 607 FYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYL 666 FYFGG+HGV S+AR GGLKKLVG NLE IDAREVNSIKLFDD+ GR + VRVG+NG YL Sbjct 602 FYFGGEHGVEGSIAREGGLKKLVGGNLEEIDAREVNSIKLFDDSEGRAVNVRVGRNGAYL 661 Query 667 ERLVA--GDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAR 724 ER+VA + GE PQRANL D +TPDELTL++AE+LFATPQ+GR+LG+DP TGHEIVA+ Sbjct 662 ERMVADPDNPGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGIDPATGHEIVAK 721 Query 725 EGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLL 784 +GR+GPYVTE+LPEP D A A K ++ KPRTGSLLRSMDL+TVTL+DALRLL Sbjct 722 DGRYGPYVTEVLPEPPDDGEAGATAKKGKKPTGP-KPRTGSLLRSMDLETVTLDDALRLL 780 Query 785 SLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRR 844 SLPRVVGVDPA+GEEITAQNGRYGPYLKRG DSRSL TE+Q+F ITL+EALKIYAEPKRR Sbjct 781 SLPRVVGVDPANGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRR 840 Query 845 GRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAEL 904 GRQ A+ PPLRELG DP S KPMVIKDGRFGPYVTDGETNASLRKGDDV SITD RA+EL Sbjct 841 GRQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASEL 900 Query 905 LADRRARGP 913 LADRRARGP Sbjct 901 LADRRARGP 909 >gi|315446274|ref|YP_004079153.1| DNA topoisomerase I [Mycobacterium sp. Spyr1] gi|315264577|gb|ADU01319.1| DNA topoisomerase I [Mycobacterium sp. Spyr1] Length=941 Score = 1453 bits (3762), Expect = 0.0, Method: Compositional matrix adjust. Identities = 731/908 (81%), Positives = 804/908 (89%), Gaps = 7/908 (0%) Query 9 RGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPW 68 RGSG NGS RRLVIVESPTKARK+A YLGS Y+VESSRGHIRDLPRAA+DVPAKYKS+PW Sbjct 6 RGSGKNGSVRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRAAADVPAKYKSEPW 65 Query 69 ARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLK 128 ARLGVNVDADFEPLYIISP+K++TV++L+ LK+VDELYLATDGDREGEAIAWHLLETLK Sbjct 66 ARLGVNVDADFEPLYIISPDKKATVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLK 125 Query 129 PRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP 188 PRIPVKRMVFHEITEPAIRAAAE PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAP Sbjct 126 PRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAP 185 Query 189 KLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAG 248 KLSAGRVQSVATRIIV RER+RMAFRSA YWD+ A+LDASVSD A PPTF A+L V G Sbjct 186 KLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQATPPTFVAKLNTVDG 245 Query 249 RRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFM 308 RRVA GRDFDSLG ++K EV+VLDE +A ALA GL G QL+V+S E+KPY RRPY PFM Sbjct 246 RRVAAGRDFDSLGAVKKPGEVLVLDEAAANALAGGLRGAQLSVSSVEQKPYTRRPYAPFM 305 Query 309 TSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGD 368 TSTLQQEA RKLR S+ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYG+ Sbjct 306 TSTLQQEAGRKLRMSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGE 365 Query 369 EYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTV 428 EYV P PRQYTRKVKNAQEAHEAIRPAG+ F TP + +LD D+FRLYELIWQRTV Sbjct 366 EYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSQLD---TDEFRLYELIWQRTV 422 Query 429 ASQMADARGMTLSLRITGMS-GHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAE 487 ASQMADARG TLSLRI G + ++VVF+A+GRT+TF GFLKAYVE++DE GGEADDAE Sbjct 423 ASQMADARGTTLSLRIAGQARTGEQVVFNASGRTITFAGFLKAYVESLDEQAGGEADDAE 482 Query 488 RRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDR 547 RLP+LT GQR+D +LT DGH T+PPARYTEASL+KALE+LGIGRPSTYSSIIKTIQDR Sbjct 483 SRLPNLTQGQRVDAKDLTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDR 542 Query 548 GYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNF 607 GYVHKKGSALVPSWVAFAV GLLEQHF RLVDYDFTAAMEDELDEIAAGNERRTNWLNNF Sbjct 543 GYVHKKGSALVPSWVAFAVIGLLEQHFSRLVDYDFTAAMEDELDEIAAGNERRTNWLNNF 602 Query 608 YFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLE 667 YFGG+HGV S+AR GGLKKLVG NLE IDAREVNSIKLFDD+ GR + VRVG+NG YLE Sbjct 603 YFGGEHGVEGSIAREGGLKKLVGGNLEEIDAREVNSIKLFDDSEGRAVNVRVGRNGAYLE 662 Query 668 RLVA--GDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVARE 725 R+VA + GE PQRANL D +TPDELTL++AE+LFATPQ+GR+LG+DP TGHEIVA++ Sbjct 663 RMVADPDNPGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGIDPATGHEIVAKD 722 Query 726 GRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLS 785 GR+GPYVTE+LPEP D A A K ++ KPRTGSLLRSMDL+TVTL+DALRLLS Sbjct 723 GRYGPYVTEVLPEPPDDGEAGATAKKGKKPTGP-KPRTGSLLRSMDLETVTLDDALRLLS 781 Query 786 LPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRG 845 LPRVVGVDPA+GEEITAQNGRYGPYLKRG DSRSL TE+Q+F ITL+EALKIY+EPKRRG Sbjct 782 LPRVVGVDPANGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYSEPKRRG 841 Query 846 RQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELL 905 RQ A+ PPLRELG DP S KPMVIKDGRFGPYVTDGETNASLRKGDDV SITD RA+ELL Sbjct 842 RQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELL 901 Query 906 ADRRARGP 913 ADRRARGP Sbjct 902 ADRRARGP 909 >gi|108801759|ref|YP_641956.1| DNA topoisomerase I [Mycobacterium sp. MCS] gi|119870910|ref|YP_940862.1| DNA topoisomerase I [Mycobacterium sp. KMS] gi|126437746|ref|YP_001073437.1| DNA topoisomerase I [Mycobacterium sp. JLS] gi|108772178|gb|ABG10900.1| DNA topoisomerase I [Mycobacterium sp. MCS] gi|119696999|gb|ABL94072.1| DNA topoisomerase I [Mycobacterium sp. KMS] gi|126237546|gb|ABO00947.1| DNA topoisomerase I [Mycobacterium sp. JLS] Length=957 Score = 1453 bits (3761), Expect = 0.0, Method: Compositional matrix adjust. Identities = 734/903 (82%), Positives = 806/903 (90%), Gaps = 7/903 (0%) Query 14 NGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGV 73 NGS RRLVIVESPTKARK+A YLGS YIVESSRGHIRDLPRAA+DVPAKYKS+PWARLGV Sbjct 29 NGSVRRLVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGV 88 Query 74 NVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPV 133 +V+ DFEPLYIISP+K+STV++L+ LK+VDELYLATDGDREGEAIAWHLLETLKPRIPV Sbjct 89 DVEHDFEPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPV 148 Query 134 KRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAG 193 KRMVFHEITEPAIRAAAE PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAG Sbjct 149 KRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAG 208 Query 194 RVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVAT 253 RVQSVATRIIV RER+RMAFR+A YWD+ A+LDASVSDP A PPTF+A+L +V GRRVAT Sbjct 209 RVQSVATRIIVQRERERMAFRTAGYWDVSAELDASVSDPQATPPTFTAKLNSVDGRRVAT 268 Query 254 GRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQ 313 GRDFDSLG +RK DEV+VLDE +A ALAAGL QL+V+S E+KPY RRPY PFMTSTLQ Sbjct 269 GRDFDSLGQVRKPDEVLVLDEAAAGALAAGLQAAQLSVSSVEQKPYTRRPYAPFMTSTLQ 328 Query 314 QEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAP 373 QEA RKLRFS+ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYG+EYV P Sbjct 329 QEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHP 388 Query 374 APRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMA 433 RQYTRKVKNAQEAHEAIRPAG+ F TP + +LD D+FRLYELIWQRTVASQMA Sbjct 389 TARQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHAQLD---TDEFRLYELIWQRTVASQMA 445 Query 434 DARGMTLSLRITGMS-GHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPH 492 DARG TLSLRI G S Q VVFSA+GRT+TF GFLKAYVE++DEL GGE+DDAE RLP+ Sbjct 446 DARGTTLSLRIAGDSRDGQSVVFSASGRTITFAGFLKAYVESIDELAGGESDDAESRLPN 505 Query 493 LTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHK 552 LT GQR+D ELTP GH T+PPARYTEASL+KALE+LGIGRPSTYSSIIKTIQDRGYVHK Sbjct 506 LTQGQRVDAKELTPAGHQTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHK 565 Query 553 KGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGD 612 KGSALVPSWVAFAV GLLEQHFGRLVDY FTAAMEDELDEIA+G ERRTNWL NFYFGG+ Sbjct 566 KGSALVPSWVAFAVIGLLEQHFGRLVDYGFTAAMEDELDEIASGTERRTNWLKNFYFGGE 625 Query 613 HGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAG 672 HGV DS+AR+GGLKKLVG+NLE IDAREVNSIKLFDD GRPIYVRVGKNGPYLER+VA Sbjct 626 HGVGDSIARAGGLKKLVGVNLEEIDAREVNSIKLFDDAEGRPIYVRVGKNGPYLERMVAD 685 Query 673 DT--GEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGP 730 + GE PQRANL D +TPDELTL++AE+LF+TPQ+GRTLG+DPETGHEIVA++GR+GP Sbjct 686 EENPGELKPQRANLKDELTPDELTLELAEKLFSTPQEGRTLGVDPETGHEIVAKDGRYGP 745 Query 731 YVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVV 790 YVTE+LP P + A K ++ KPRTGSLLR+MDL+TVTL+DAL+LLSLPRVV Sbjct 746 YVTEVLPAPPEEPEDGAPAKKGKKPTGP-KPRTGSLLRTMDLETVTLDDALKLLSLPRVV 804 Query 791 GVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSAS 850 GVDP +GEEITAQNGRYGPYLKRG DSRSL TE+Q+FTITLDEALKIYAEPKRRGRQ A+ Sbjct 805 GVDPNTGEEITAQNGRYGPYLKRGTDSRSLATEEQMFTITLDEALKIYAEPKRRGRQGAA 864 Query 851 APPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRA 910 PPLRELG DP S KPMVIKDGRFGPYVTDGETNASLRKGDDV SITD RA+ELLADRRA Sbjct 865 TPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRA 924 Query 911 RGP 913 RGP Sbjct 925 RGP 927 >gi|169627593|ref|YP_001701242.1| DNA topoisomerase I [Mycobacterium abscessus ATCC 19977] gi|169239560|emb|CAM60588.1| DNA topoisomerase I (Omega-protein) [Mycobacterium abscessus] Length=930 Score = 1451 bits (3757), Expect = 0.0, Method: Compositional matrix adjust. Identities = 723/909 (80%), Positives = 795/909 (88%), Gaps = 17/909 (1%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKARK+A YLG GY+VESSRGHIRDLPRAA+DVPAKYKS+PWARLGVNVDA Sbjct 2 RRLVIVESPTKARKIAGYLGDGYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDA 61 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 DFEPLYI+SP+K+ TV+EL+GLLKDVDELYLATDGDREGEAIAWHLLETLKP++PV+RMV Sbjct 62 DFEPLYIVSPDKKGTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPKVPVRRMV 121 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITE AI AAA+ PRDLD +LVDAQETRRILDRLYGYEVSPVLWKKV LSAGRVQS Sbjct 122 FHEITEQAILAAAQDPRDLDNNLVDAQETRRILDRLYGYEVSPVLWKKVGRNLSAGRVQS 181 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATRIIV RERDRMAFRSA YWD+ A+LDA +P A PP F ARL +V RVA+GRDF Sbjct 182 VATRIIVQRERDRMAFRSAGYWDLGAELDAGKDNPAAKPPRFHARLVSVDALRVASGRDF 241 Query 258 DSLGTLRK---GDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQ 314 DSLG +++ G V+VLDE A AL AGL LTV SAEEKPY R+PYPPFMTSTLQQ Sbjct 242 DSLGQVKETSNGPGVLVLDETRANALVAGLSQATLTVVSAEEKPYTRKPYPPFMTSTLQQ 301 Query 315 EASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPA 374 EA RKLRFS+ERTMSIAQRLYENGYITYMRTDSTTLS+SA+ AAR+QA +LYG+EYV P+ Sbjct 302 EAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSDSALQAARSQAAELYGNEYVHPS 361 Query 375 PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMAD 434 PRQYTRKVKNAQEAHEAIRPAGETF TP + LD D+FRLYELIWQRTVASQMAD Sbjct 362 PRQYTRKVKNAQEAHEAIRPAGETFKTPGQLHSSLDN---DEFRLYELIWQRTVASQMAD 418 Query 435 ARGMTLSLRITG--MSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPH 492 ARG TLSLR+ G SG Q VVF+A+GRT+TFPGFL AYVETVDEL GGEADD ERRLP Sbjct 419 ARGTTLSLRLAGTATSGEQ-VVFTASGRTITFPGFLSAYVETVDELSGGEADDEERRLPQ 477 Query 493 LTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHK 552 L GQ + + EL+ DGH TNPPARYTEASL+KALEELGIGRPSTYSSII+TIQDRGYVHK Sbjct 478 LRQGQSVTVAELSADGHTTNPPARYTEASLIKALEELGIGRPSTYSSIIRTIQDRGYVHK 537 Query 553 KGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGD 612 +GSALVPSW AFAV GLLEQHFGRLVDYDFTAAMED+LDEIA+GNERRTNWLN FYFGGD Sbjct 538 RGSALVPSWTAFAVIGLLEQHFGRLVDYDFTAAMEDDLDEIASGNERRTNWLNAFYFGGD 597 Query 613 HGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVA- 671 HGV SVAR+GGLK+LVG+NLE IDARE+NSIKLFDD GRPIYVRVGKNGPYLER+VA Sbjct 598 HGVEGSVARAGGLKRLVGVNLEEIDAREINSIKLFDDDQGRPIYVRVGKNGPYLERMVAD 657 Query 672 --GDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFG 729 G+ G PQRAN+ D +TPDELT+++AE+LFA PQ+GRTLG+DPETGHEIVA++GRFG Sbjct 658 PDGEAGALIPQRANVKDGVTPDELTVEMAEQLFAIPQEGRTLGVDPETGHEIVAKDGRFG 717 Query 730 PYVTEILPEP--AADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLP 787 PYVTE+LP P +A +G KK + GPKPRTGSLL+SM L+TVTLEDALRLLSLP Sbjct 718 PYVTEVLPAPPEPVEAEKPKRGAKKVE---GPKPRTGSLLKSMTLETVTLEDALRLLSLP 774 Query 788 RVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQ 847 RVVGVDPASGEEITAQNGRYGPYLKRG DSRSL TE QIFT+TLDEALKIY+EPKRRG Q Sbjct 775 RVVGVDPASGEEITAQNGRYGPYLKRGTDSRSLATEGQIFTVTLDEALKIYSEPKRRGGQ 834 Query 848 SASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLAD 907 +ASA PLRELG D A+GKPMVIKDGRFGPYVTDGETNASLRKGDDV SITDERA+ELLAD Sbjct 835 AASAAPLRELGVDSATGKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDERASELLAD 894 Query 908 RRARGPAKR 916 RRARGP KR Sbjct 895 RRARGPVKR 903 >gi|339296459|gb|AEJ48570.1| DNA topoisomerase I [Mycobacterium tuberculosis CCDC5079] Length=692 Score = 1396 bits (3614), Expect = 0.0, Method: Compositional matrix adjust. Identities = 688/689 (99%), Positives = 689/689 (100%), Gaps = 0/689 (0%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +ADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP Sbjct 1 MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA Sbjct 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS Sbjct 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA Sbjct 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART Sbjct 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY Sbjct 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 Query 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG Sbjct 421 ELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVG 480 Query 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI Sbjct 481 GEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 540 Query 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR Sbjct 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERR 600 Query 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG Sbjct 601 TNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 Query 661 KNGPYLERLVAGDTGEPTPQRANLSDSIT 689 KNGPYLERLVAGDTGEPTPQRANLSDSIT Sbjct 661 KNGPYLERLVAGDTGEPTPQRANLSDSIT 689 >gi|54022331|ref|YP_116573.1| DNA topoisomerase I [Nocardia farcinica IFM 10152] gi|54013839|dbj|BAD55209.1| putative DNA topoisomerase I [Nocardia farcinica IFM 10152] Length=976 Score = 1355 bits (3507), Expect = 0.0, Method: Compositional matrix adjust. Identities = 692/915 (76%), Positives = 768/915 (84%), Gaps = 14/915 (1%) Query 6 TKGRGSGGNGSG-RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYK 64 T+ RG+ G RRLVIVESPTKARK+A YLG Y VE+S GHIRDLPR A+DVPAKYK Sbjct 7 TRDRGAADQGRPLRRLVIVESPTKARKIAPYLGRNYTVEASVGHIRDLPRGAADVPAKYK 66 Query 65 SQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLL 124 QPWARLGV+VD DFEP+Y++SP+K++ V+EL+ LL D DELYLATD DREGEAIAWHLL Sbjct 67 GQPWARLGVDVDNDFEPIYVVSPDKKAKVTELKSLLADADELYLATDPDREGEAIAWHLL 126 Query 125 ETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWK 184 ETLKP++PV+RMVFHEITEPAIRAAA R+LD DLVDAQETRRILDRLYGYEVSPVLWK Sbjct 127 ETLKPKVPVRRMVFHEITEPAIRAAAADTRELDPDLVDAQETRRILDRLYGYEVSPVLWK 186 Query 185 KVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSD-PDAAPP-TFSAR 242 KV PKLSAGRVQSVATR+IV RER+RMAFRSA YWDI AKLDA + DAA P TF AR Sbjct 187 KVMPKLSAGRVQSVATRVIVQRERERMAFRSAEYWDIAAKLDAGADEQSDAANPRTFGAR 246 Query 243 LTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARR 302 L V G RVA+GRDF G L+ V+VLDE A LA LDG L V SAE KPY+R+ Sbjct 247 LVNVDGARVASGRDFGPDGQLKSASGVVVLDEARARRLAEALDGVDLAVTSAESKPYSRK 306 Query 303 PYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQA 362 PYPPFMTSTLQQEA RKLRF++ERTM +AQRLYENGYITYMRTDSTTLSESAI AAR+QA Sbjct 307 PYPPFMTSTLQQEAGRKLRFTSERTMRVAQRLYENGYITYMRTDSTTLSESAIAAARSQA 366 Query 363 RQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYEL 422 QLYG EYV P+PRQY RKVKNAQEAHEAIRPAG+TFATP + LD D+FRLYEL Sbjct 367 TQLYGAEYVHPSPRQYNRKVKNAQEAHEAIRPAGDTFATPGQLHSRLDN---DEFRLYEL 423 Query 423 IWQRTVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGG 481 IWQRTVASQMADARG TL+LRITG++G +E VFSA+GRT+TFPGFLKAYVE+VDE GG Sbjct 424 IWQRTVASQMADARGTTLTLRITGVAGTGEECVFSASGRTITFPGFLKAYVESVDEEAGG 483 Query 482 EADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSII 541 ++DDAE RLP L GQ + VEL PDGH+TNPPARYTEASL+KALEELGIGRPSTYSSII Sbjct 484 QSDDAESRLPALEEGQNVTAVELNPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSII 543 Query 542 KTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRT 601 KTI DRGYV+K+GSALVPSWVAFAV GLLE +FGRLVD+DFTAAMED+LD IA+G ERR Sbjct 544 KTILDRGYVYKRGSALVPSWVAFAVVGLLEAYFGRLVDFDFTAAMEDDLDAIASGRERRG 603 Query 602 NWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGK 661 NWL++FYFGGD GV SVARSGGLKK+VG L+ IDAREVNSIKLF D GR + VRVG+ Sbjct 604 NWLSSFYFGGDSGVEGSVARSGGLKKMVGEQLDDIDAREVNSIKLFTDAEGRDVVVRVGR 663 Query 662 NGPYLERLVA---GDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETG 718 GPYLERLV G+P QRANL D + PDELT +VAE+LFATPQ+GR+LG+DP TG Sbjct 664 YGPYLERLVTDPDDPDGDPISQRANLPDDLPPDELTPEVAEKLFATPQEGRSLGVDPATG 723 Query 719 HEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLE 778 HEIVA+EGRFGPYVTEILPEPA + A KK RTGSL +SMDL ++TL+ Sbjct 724 HEIVAKEGRFGPYVTEILPEPATEEGAKKTAAKKTAPKP----RTGSLFKSMDLASITLD 779 Query 779 DALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIY 838 DAL+LLSLPRVVG DPA+GEEITAQNGRYGPYLK+G DSRSL +EDQIFTITLDEALKIY Sbjct 780 DALKLLSLPRVVGTDPATGEEITAQNGRYGPYLKKGTDSRSLASEDQIFTITLDEALKIY 839 Query 839 AEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITD 898 AEPKRRG QSASA PLRELGTDP SGKPMVIKDGRFGPYVTDGETNASLRKGD+V SITD Sbjct 840 AEPKRRGGQSASAAPLRELGTDPVSGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITD 899 Query 899 ERAAELLADRRARGP 913 ERAAELLADRRARGP Sbjct 900 ERAAELLADRRARGP 914 >gi|333917966|ref|YP_004491547.1| DNA topoisomerase [Amycolicicoccus subflavus DQS3-9A1] gi|333480187|gb|AEF38747.1| DNA topoisomerase [Amycolicicoccus subflavus DQS3-9A1] Length=934 Score = 1333 bits (3449), Expect = 0.0, Method: Compositional matrix adjust. Identities = 679/919 (74%), Positives = 769/919 (84%), Gaps = 30/919 (3%) Query 9 RGSG-GNGSGR--------RLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDV 59 RGSG NGS R RLVIVESPTKA+K+ASYLGSGY+VESSRGHIRDLP+ A+DV Sbjct 4 RGSGTANGSARAGDSRVVRRLVIVESPTKAKKIASYLGSGYVVESSRGHIRDLPKGAADV 63 Query 60 PAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAI 119 PAKYK + WARLGVNVD DFEPLY++S +K++TVSEL+GLLKDVDELYLATDGDREGEAI Sbjct 64 PAKYKGEAWARLGVNVDEDFEPLYVVSADKKATVSELKGLLKDVDELYLATDGDREGEAI 123 Query 120 AWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVS 179 AWHLLETLKP+IPV+RMVFHEITEPAIRAAAE+PRDLD DLVDAQETRRI+DRLYGYEVS Sbjct 124 AWHLLETLKPKIPVRRMVFHEITEPAIRAAAENPRDLDSDLVDAQETRRIVDRLYGYEVS 183 Query 180 PVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTF 239 PVLWKKV PKLSAGRVQSVATRIIV RER+RM F +A YWDI A LDA P TF Sbjct 184 PVLWKKVMPKLSAGRVQSVATRIIVQRERERMEFTAAEYWDIAATLDAGSG---VTPQTF 240 Query 240 SARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPY 299 A+L +V G RVATGRDF G L+ V VLDE A LA L G L V SAEEKPY Sbjct 241 GAKLMSVGGERVATGRDFGPNGALKSSSAVRVLDEAHAGRLAEALQGQALAVTSAEEKPY 300 Query 300 ARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAAR 359 RRPY PFMTSTLQQEA RKLRFSA+RTM IAQRLYENGYITYMRTDSTTLS SAI+AAR Sbjct 301 TRRPYAPFMTSTLQQEAGRKLRFSADRTMRIAQRLYENGYITYMRTDSTTLSSSAIDAAR 360 Query 360 TQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRL 419 QAR+LYG EYVAP+PRQYTRKVKNAQEAHEAIRPAGETF TP + R L+ D+FRL Sbjct 361 NQARELYGPEYVAPSPRQYTRKVKNAQEAHEAIRPAGETFQTPGQLHRVLEA---DEFRL 417 Query 420 YELIWQRTVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDEL 478 YELIWQRTVASQMADA+G TLSLRITG + +E VFS++GRT+TFPGFL AYVETVDE Sbjct 418 YELIWQRTVASQMADAKGTTLSLRITGTAATGEECVFSSSGRTITFPGFLSAYVETVDEE 477 Query 479 VGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYS 538 GG+ADD ERRLP LT G + EL PDGH+T+PP+RYTEASLVK LE+ GIGRPSTY+ Sbjct 478 AGGQADDEERRLPRLTEGHAVTASELRPDGHSTSPPSRYTEASLVKKLEDEGIGRPSTYA 537 Query 539 SIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNE 598 SIIKTIQDRGYV+KKG+ALVPSWVAFAV GLLE+HFGRLVDY+FTA+MED+LD IA G E Sbjct 538 SIIKTIQDRGYVYKKGNALVPSWVAFAVVGLLERHFGRLVDYNFTASMEDDLDAIAEGRE 597 Query 599 RRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVR 658 RR++WL FYFG D ++A+ GGLK+LVG+NLEGIDARE+NSI LFDD+ GRP+ VR Sbjct 598 RRSDWLAAFYFGSDDRAEGTLAKLGGLKRLVGVNLEGIDAREINSITLFDDSDGRPVNVR 657 Query 659 VGKNGPYLERLVA-GDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 VG+ GPYLER + GD E QRANL + + PDELT ++AE+LF+TPQ+GR LG+DP+T Sbjct 658 VGRFGPYLERTIGEGDAAE--SQRANLPEDLPPDELTREIAEKLFSTPQEGRVLGVDPDT 715 Query 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 GHE+VA+EGRFGPYVTEI+P+ + G KK KPRTGSLL+SM++ TVTL Sbjct 716 GHEVVAKEGRFGPYVTEIIPDDEKNG-----GAKK------VKPRTGSLLKSMEISTVTL 764 Query 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 E+AL+LL+LPRVVG DP SG+EITAQNGRYGPYLK+G+DSRSL TEDQIFT+TLDEALKI Sbjct 765 EEALKLLALPRVVGKDPESGDEITAQNGRYGPYLKKGSDSRSLATEDQIFTVTLDEALKI 824 Query 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 YAEPKRRGRQ+A+ PLRE+G DPA+GKPMVIKDGRFGPYVTDGETNASLRKGD+VA++T Sbjct 825 YAEPKRRGRQAAATEPLREVGNDPATGKPMVIKDGRFGPYVTDGETNASLRKGDEVATLT 884 Query 898 DERAAELLADRRARGPAKR 916 ER AELLADRRARGP KR Sbjct 885 VERGAELLADRRARGPVKR 903 >gi|331694279|ref|YP_004330518.1| DNA topoisomerase I [Pseudonocardia dioxanivorans CB1190] gi|326948968|gb|AEA22665.1| DNA topoisomerase I [Pseudonocardia dioxanivorans CB1190] Length=952 Score = 1333 bits (3449), Expect = 0.0, Method: Compositional matrix adjust. Identities = 673/907 (75%), Positives = 759/907 (84%), Gaps = 21/907 (2%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKA+K+A YLG Y+VESS GHIRDLPR A+DVPAKYK + WARLGV+VD Sbjct 39 RRLVIVESPTKAKKIAPYLGKDYVVESSVGHIRDLPRGAADVPAKYKGESWARLGVDVDN 98 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 +F+PLYI++PEK+ VSELR LK VDEL LATD DREGEAIAWHLL+TLKP++PV+RMV Sbjct 99 EFQPLYIVTPEKKGKVSELRDALKSVDELLLATDPDREGEAIAWHLLDTLKPKVPVRRMV 158 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITEPAIRAAAE+ RDLD DLVDAQETRRILDRLYGYEVSPVLW+KV PKLSAGRVQS Sbjct 159 FHEITEPAIRAAAENLRDLDQDLVDAQETRRILDRLYGYEVSPVLWRKVMPKLSAGRVQS 218 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATR+IV RER+RMAF SA+YWDI A LDA +A+P TF ARL AV G RVATGRDF Sbjct 219 VATRLIVQRERERMAFVSASYWDIAATLDAGA---EASPRTFGARLVAVDGNRVATGRDF 275 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 + G L+ + + LDE A LA LDG LTV+S E KPY R+PY PFMTSTLQQEA Sbjct 276 GADGQLKS--DAVALDEAGARRLAEALDGVDLTVSSVESKPYTRKPYAPFMTSTLQQEAG 333 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRFSAERTM AQRLYENGYITYMRTDSTTLSESAINAARTQAR+LYGD YV+P PRQ Sbjct 334 RKLRFSAERTMRTAQRLYENGYITYMRTDSTTLSESAINAARTQARELYGDSYVSPQPRQ 393 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 YTRKVKNAQEAHEAIRPAGETF TP V RE+DG DDFRLYELIWQRTVASQMADARG Sbjct 394 YTRKVKNAQEAHEAIRPAGETFRTPGEVAREVDG---DDFRLYELIWQRTVASQMADARG 450 Query 438 MTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPG 496 T+S+RI G + +E F+A+GRT+TFPGFLKAYVETV+E G+ADDAE RLP+L G Sbjct 451 TTMSVRIVGTAATGEEATFAASGRTITFPGFLKAYVETVEEGTDGQADDAESRLPNLAEG 510 Query 497 QRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSA 556 + EL PDGH+TNPPARYTE SLVK LEELGIGRPSTY+SIIKTIQDRGYV KKGSA Sbjct 511 AAVTATELNPDGHSTNPPARYTEPSLVKQLEELGIGRPSTYASIIKTIQDRGYVWKKGSA 570 Query 557 LVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVP 616 LVPSWVAF+V GLLE HFGRLVDYDFTAAMEDELD IA+GN RT+WL +FYFG D G Sbjct 571 LVPSWVAFSVIGLLEHHFGRLVDYDFTAAMEDELDAIASGNYSRTDWLTSFYFGADEGTE 630 Query 617 DSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGE 676 SVAR+GGLKKLVG+NLE IDAREVNSI +F D GR + VRVG+ GPYLERLV G + Sbjct 631 GSVARAGGLKKLVGVNLEEIDAREVNSIPMFTDAEGRDVVVRVGRYGPYLERLVEGAS-- 688 Query 677 PTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEIL 736 QRANL D + PDELT ++AE+LF+ PQ+GR+LG DP TGHEIVA+EGRFGPYVTEIL Sbjct 689 ---QRANLPDDLPPDELTAEIAEKLFSVPQEGRSLGTDPVTGHEIVAKEGRFGPYVTEIL 745 Query 737 PEPAADAAAAAQGVKKRQKA-AGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPA 795 PEP A A+G R+KA A PKPRTGSLL+SM +++VTL+DALRLLSLPR+VG DP Sbjct 746 PEP----EAPAEGTTTRKKAPAKPKPRTGSLLKSMTVESVTLDDALRLLSLPRLVGTDPE 801 Query 796 SGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASA-PPL 854 SGEEITAQNGRYGPYLK+G DSRSL E+Q+FT+TLDEAL+IY +PK+RGR++A+A PPL Sbjct 802 SGEEITAQNGRYGPYLKKGTDSRSLTDEEQMFTVTLDEALEIYKQPKQRGRRTAAATPPL 861 Query 855 RELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPA 914 RELG D A+GK MVIKDGRFGPYVTDGETNASLRKGD V ITDERA+ELLADRR++ P Sbjct 862 RELGEDSATGKKMVIKDGRFGPYVTDGETNASLRKGDSVEEITDERASELLADRRSKAPV 921 Query 915 KR-PARK 920 K+ PAR+ Sbjct 922 KKAPARR 928 >gi|343926496|ref|ZP_08766001.1| DNA topoisomerase I [Gordonia alkanivorans NBRC 16433] gi|343763734|dbj|GAA12927.1| DNA topoisomerase I [Gordonia alkanivorans NBRC 16433] Length=1020 Score = 1319 bits (3414), Expect = 0.0, Method: Compositional matrix adjust. Identities = 683/978 (70%), Positives = 767/978 (79%), Gaps = 79/978 (8%) Query 1 LADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVP 60 +A+ T R SGG RRLVIVESPTKARK+A YLGS Y+VESSRGHIRDLPR A+DVP Sbjct 1 MAETSTASRSSGGI---RRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGAADVP 57 Query 61 AKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIA 120 AKYK QPWARLGVNVD +FEPLY++SP+K++TVSEL+ L+KDVDELYLATDGDREGEAIA Sbjct 58 AKYKGQPWARLGVNVDDNFEPLYVVSPDKKTTVSELKSLMKDVDELYLATDGDREGEAIA 117 Query 121 WHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSP 180 WHLLETLKP+IPVKRMVFHEITEPAIRAAAE+PRDLDIDLVDAQETRRILDRLYGYEVSP Sbjct 118 WHLLETLKPKIPVKRMVFHEITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSP 177 Query 181 VLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFS 240 VLWKKV PKLSAGRVQSVATRIIV RER+RMAF SA YWDI A +DA +A+P TF Sbjct 178 VLWKKVMPKLSAGRVQSVATRIIVERERERMAFVSAEYWDIAATMDAGA---EASPSTFK 234 Query 241 ARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYA 300 ARL V RVATGRDF++ G L+K D V+VL+ A +LAAGL G +TV S EEKPY Sbjct 235 ARLVNVDDARVATGRDFEATGELKKPDGVVVLNADRAESLAAGLRGAAMTVTSVEEKPYT 294 Query 301 RRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 360 RRPY PFMTSTLQQEA RKLRF+++RTM IAQRLYENG+ITYMRTDST+LSESAINAAR Sbjct 295 RRPYAPFMTSTLQQEAGRKLRFTSDRTMRIAQRLYENGFITYMRTDSTSLSESAINAARA 354 Query 361 QARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLY 420 QAR+LYGD +V P PRQYTRKVKNAQEAHEAIRPAGETF TP V +L+ D+FRLY Sbjct 355 QARELYGDNFVHPTPRQYTRKVKNAQEAHEAIRPAGETFRTPGQVAGQLEA---DEFRLY 411 Query 421 ELIWQRTVASQMADARGMTLSLRITGM-SGHQEVVFSATGRTLTFPGFLKAYVETVDELV 479 ELIWQRTVASQMADA+G TLSLRI G S + F+++GRT+TFPGFL AYVETVDE Sbjct 412 ELIWQRTVASQMADAKGTTLSLRIAGTASSGERATFASSGRTITFPGFLSAYVETVDEQT 471 Query 480 GGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSS 539 GG+ADDAE RLP LT GQ L ELT DGH+TNPPAR+TEASLVK LEELGIGRPSTY+S Sbjct 472 GGQADDAENRLPQLTEGQSLTATELTADGHSTNPPARFTEASLVKVLEELGIGRPSTYAS 531 Query 540 IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNER 599 II TIQDRGYV KKG+ALVPSW+AFAV GLLE +F LVDYDFTA +ED+LD+IA GNE Sbjct 532 IIGTIQDRGYVVKKGNALVPSWIAFAVVGLLEAYFESLVDYDFTATLEDDLDQIATGNEN 591 Query 600 RTNWLNNFYFG----GD---HGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHG 652 RT WL+ FYFG GD ++A+ GGLKKLVG+NLE IDAR+VNSI+LFDD G Sbjct 592 RTKWLSEFYFGDERSGDAEARSAHSAIAQYGGLKKLVGVNLEEIDARQVNSIRLFDDEEG 651 Query 653 RPIYVRVGKNGPYLERLVAGDT-----GEPTPQRANLSDSITPDELTLQVAEELFATPQQ 707 RPIYVRVG+ GPYLER + + EP QRANL ITPDELTL++AE+LF+TPQ+ Sbjct 652 RPIYVRVGRFGPYLERDLNANKKTDADAEPDLQRANLPADITPDELTLEIAEKLFSTPQE 711 Query 708 GRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPR----- 762 GR+LG+DP TGHEIVA+EGRFGPYVTEILP G AGP PR Sbjct 712 GRSLGVDPLTGHEIVAKEGRFGPYVTEILPA----DDDDDDGEAPITIPAGPTPRDGGSP 767 Query 763 ----------------------------------------------TGSLLRSMDLQTVT 776 TGSL +SMD+ TVT Sbjct 768 GTGGSDAGDADVVPLDSPGGGTTTKTKPAAKKVAKKAAKKAGPKPRTGSLFKSMDISTVT 827 Query 777 LEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALK 836 L++AL+LLSLPRVVGVDP SG+EITAQNGRYGPYLK+G+DSRSL +E+Q+F ITLDEALK Sbjct 828 LDEALKLLSLPRVVGVDPESGDEITAQNGRYGPYLKKGSDSRSLGSEEQLFEITLDEALK 887 Query 837 IYAEPKRRGRQSASAPPLRELGT-DPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVAS 895 IY+EPKRRGRQ A+APPLRELG D SGKPMVIKDGRFGPYVTDGETNASLRKGD+V S Sbjct 888 IYSEPKRRGRQ-AAAPPLRELGKDDEVSGKPMVIKDGRFGPYVTDGETNASLRKGDEVDS 946 Query 896 ITDERAAELLADRRARGP 913 IT ERA ELLADRRARGP Sbjct 947 ITPERAMELLADRRARGP 964 >gi|262200589|ref|YP_003271797.1| DNA topoisomerase I [Gordonia bronchialis DSM 43247] gi|262083936|gb|ACY19904.1| DNA topoisomerase I [Gordonia bronchialis DSM 43247] Length=1031 Score = 1318 bits (3411), Expect = 0.0, Method: Compositional matrix adjust. Identities = 679/963 (71%), Positives = 763/963 (80%), Gaps = 78/963 (8%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKARK+A YLGS Y+VESSRGHIRDLPR A+DVPAKYK QPWARLGVNVD Sbjct 16 RRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGAADVPAKYKGQPWARLGVNVDE 75 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 +FEPLY++SP+K+STV+EL+ L++DVDELYLATDGDREGEAIAWHLLETLKP+IPVKRMV Sbjct 76 NFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWHLLETLKPKIPVKRMV 135 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITEPAIRAAAE+PRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQS Sbjct 136 FHEITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQS 195 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATRIIV RER+RMAF SA YWDI A +DA DA+P TF+ARL V RVATGRDF Sbjct 196 VATRIIVERERERMAFVSAEYWDIDANMDAG---KDASPQTFNARLVGVDDARVATGRDF 252 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 DS G L++ D V+VLDE A ALA LDG +TV+S EEKPY RRPY PFMTSTLQQEA Sbjct 253 DSRGALKRADGVVVLDETRARALADALDGADITVSSVEEKPYTRRPYAPFMTSTLQQEAG 312 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRFS++RTM IAQRLYENG+ITYMRTDSTTLSESAINAAR QAR+LYGD YV P PRQ Sbjct 313 RKLRFSSDRTMRIAQRLYENGFITYMRTDSTTLSESAINAARAQARELYGDNYVHPTPRQ 372 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 +TRKVKNAQEAHEAIRPAGE+F TP V +L+ D+FRLYELIWQRTVASQMADA+G Sbjct 373 HTRKVKNAQEAHEAIRPAGESFRTPGQVAGQLEA---DEFRLYELIWQRTVASQMADAKG 429 Query 438 MTLSLRITGMSGHQE-VVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPG 496 TLSLR+TG + E VF+A+GRT+TFPGFL AYVETVD+L GG+ADDAE RLP L G Sbjct 430 TTLSLRMTGTASTGETCVFAASGRTITFPGFLSAYVETVDDLAGGQADDAENRLPQLREG 489 Query 497 QRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSA 556 Q L EL+ DGH+TNPPAR+TEASLVK LEELGIGRPSTY+SII TIQDRGYV KKG+A Sbjct 490 QALRATELSADGHSTNPPARFTEASLVKVLEELGIGRPSTYASIIGTIQDRGYVVKKGNA 549 Query 557 LVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFG-----G 611 LVPSW+AFAV GLLE +F LVDYDFTA++ED+LDEIA+G E RT WL FYFG Sbjct 550 LVPSWIAFAVVGLLEAYFQGLVDYDFTASLEDDLDEIASGRENRTRWLTEFYFGDAAPNA 609 Query 612 DHGVP---DSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLER 668 +H +A+ GGLKKLVG+NLE IDAREVNSI+LFDD GRP+YVRVG+ GPYLER Sbjct 610 EHDAEIAGSEIAKHGGLKKLVGVNLEEIDAREVNSIRLFDDEQGRPVYVRVGRFGPYLER 669 Query 669 LVAGDT-----GEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVA 723 ++ + EP QRANL ITPDELTL +AE+LF+TPQ+GR+LG+DP TGHEIVA Sbjct 670 NLSAASAASPDAEPDLQRANLPADITPDELTLALAEKLFSTPQEGRSLGVDPVTGHEIVA 729 Query 724 REGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKP---------------------- 761 +EGRFGPYVTEILP G AGP P Sbjct 730 KEGRFGPYVTEILPS----DDDDDDGNSPATVPAGPTPRDGGGTGGQGSDAEVVPLDTPS 785 Query 762 ------------------------------RTGSLLRSMDLQTVTLEDALRLLSLPRVVG 791 RTGSL ++MD+ TVTL+DAL+LLSLPRVVG Sbjct 786 GGGTATKTAAKAAAKKTTAKKAAKKAGPKPRTGSLFKTMDISTVTLDDALKLLSLPRVVG 845 Query 792 VDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASA 851 VDP SG+EITAQNGRYGPYLK+G DSRSL +E+Q+F+ITLDEALKIY+EPKRRGRQ A+A Sbjct 846 VDPESGDEITAQNGRYGPYLKKGTDSRSLTSEEQLFSITLDEALKIYSEPKRRGRQ-AAA 904 Query 852 PPLRELGT-DPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRA 910 PPLR+LG D SGKPMVIKDGRFGPYVTDGETNASLRKGD+VA+IT ERA ELLADRRA Sbjct 905 PPLRDLGKEDSVSGKPMVIKDGRFGPYVTDGETNASLRKGDEVATITPERAMELLADRRA 964 Query 911 RGP 913 RGP Sbjct 965 RGP 967 >gi|312138019|ref|YP_004005355.1| DNA topoisomerase i [Rhodococcus equi 103S] gi|311887358|emb|CBH46669.1| DNA topoisomerase I [Rhodococcus equi 103S] Length=962 Score = 1313 bits (3398), Expect = 0.0, Method: Compositional matrix adjust. Identities = 681/932 (74%), Positives = 766/932 (83%), Gaps = 31/932 (3%) Query 5 KTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYK 64 + K G +G+ RRLVIVESPTKA+K+A YLG Y+VE+S GHIRDLPR A+DVPAKYK Sbjct 4 REKSTADGASGT-RRLVIVESPTKAKKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYK 62 Query 65 SQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLL 124 +PWARLGVNVD DFEPLY++SPEK+S V+EL+ LLKD DELYLATD DREGEAIAWHLL Sbjct 63 GEPWARLGVNVDHDFEPLYVVSPEKKSKVTELKSLLKDADELYLATDPDREGEAIAWHLL 122 Query 125 ETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWK 184 ETLKP+IPV+RMVFHEITEPAIRAAAE RDLD DLVDAQETRRILDRLYGYEVSPVLWK Sbjct 123 ETLKPKIPVRRMVFHEITEPAIRAAAEDTRDLDNDLVDAQETRRILDRLYGYEVSPVLWK 182 Query 185 KVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLT 244 KV PKLSAGRVQSVATR+IV RER+RMAFRSA YWDI A LDA DA+P F ARL Sbjct 183 KVMPKLSAGRVQSVATRVIVQRERERMAFRSAEYWDISATLDAGA---DASPRAFGARLV 239 Query 245 AVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPY 304 +V G RVA GRDF G L K V V+DE A LA L+G L V+SAE+KPY R+PY Sbjct 240 SVDGSRVAAGRDFGPDGKL-KSTGVTVIDEAYARRLAEALEGVDLVVSSAEDKPYTRKPY 298 Query 305 PPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQ 364 PFMTSTLQQEA+RKLRFS+ERTM +AQRLYENGYITYMRTDSTTLS+SAI+AAR QA + Sbjct 299 APFMTSTLQQEAARKLRFSSERTMRVAQRLYENGYITYMRTDSTTLSQSAISAARAQATE 358 Query 365 LYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIW 424 LYG EYV PRQYTRKVKNAQEAHEAIRPAG+ F TP + L+ D++RLYELIW Sbjct 359 LYGAEYVHATPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLEN---DEYRLYELIW 415 Query 425 QRTVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEA 483 QRTVASQMADARG TL+LRITG +G +E FSA+GRT+TFPGFLKAYVE+VDE GG++ Sbjct 416 QRTVASQMADARGTTLTLRITGTAGTGEECTFSASGRTITFPGFLKAYVESVDEEAGGQS 475 Query 484 DDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKT 543 DDAE RLP LT GQ + +L PDGH+TNPPARYTEASL+KALEELGIGRPSTYSSIIKT Sbjct 476 DDAESRLPVLTQGQEVTATKLDPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKT 535 Query 544 IQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNW 603 I DRGYV+K+GSALVPSWVAFAV GLLE HFGRLVD+DFTAAMED+LDEIA G E+R NW Sbjct 536 ILDRGYVYKRGSALVPSWVAFAVIGLLETHFGRLVDFDFTAAMEDDLDEIAGGREQRGNW 595 Query 604 LNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNG 663 L++FYFG DS+AR+GGLKK+VG NLE IDARE+NSI+LFDD GR ++VRVG+ G Sbjct 596 LSSFYFGDAAAADDSIARAGGLKKMVGQNLEDIDAREINSIRLFDDAEGREVHVRVGRFG 655 Query 664 PYLERLVAG---DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 PYLER+V G+P QRANL D + PDELT + AE+LF+TPQ+GR LG+DP TGHE Sbjct 656 PYLERMVQNPDDPDGDPVSQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHE 715 Query 721 IVAREGRFGPYVTEILP-------------EPAADAAA------AAQGVKKRQKAAGPKP 761 IVA+EGRFGPYVTEILP E AAD A K +K AGPKP Sbjct 716 IVAKEGRFGPYVTEILPEPAPEPEPDIVPVEAAADGTTKTKAVKKAPAKKAAKKVAGPKP 775 Query 762 RTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLV 821 RTGSLL+SMDL TVTLEDAL+LLSLPRVVGVDP S EEITAQNGRYGPYLK+G DSRSL Sbjct 776 RTGSLLKSMDLATVTLEDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLE 835 Query 822 TEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDG 881 EDQ+FT+TL+EALKIYAEPKRRGRQ+++A PLRELG D A+GKPMVIKDGRFGPYVTDG Sbjct 836 NEDQMFTVTLEEALKIYAEPKRRGRQASAAAPLRELGNDAATGKPMVIKDGRFGPYVTDG 895 Query 882 ETNASLRKGDDVASITDERAAELLADRRARGP 913 ETNASLRKGD+V SITDERA+ELLADRRARGP Sbjct 896 ETNASLRKGDEVESITDERASELLADRRARGP 927 >gi|325675218|ref|ZP_08154903.1| DNA topoisomerase TopA [Rhodococcus equi ATCC 33707] gi|325553924|gb|EGD23601.1| DNA topoisomerase TopA [Rhodococcus equi ATCC 33707] Length=962 Score = 1310 bits (3391), Expect = 0.0, Method: Compositional matrix adjust. Identities = 682/932 (74%), Positives = 767/932 (83%), Gaps = 31/932 (3%) Query 5 KTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYK 64 + K G +G+ RRLVIVESPTKA+K+A YLG Y+VE+S GHIRDLPR A+DVPAKYK Sbjct 4 REKSTADGASGT-RRLVIVESPTKAKKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYK 62 Query 65 SQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLL 124 +PWARLGVNVD DFEPLY++SPEK+S V+EL+ LLKD DELYLATD DREGEAIAWHLL Sbjct 63 GEPWARLGVNVDHDFEPLYVVSPEKKSKVTELKSLLKDADELYLATDPDREGEAIAWHLL 122 Query 125 ETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWK 184 ETLKP+IPV+RMVFHEITEPAIRAAAE RDLD DLVDAQETRRILDRLYGYEVSPVLWK Sbjct 123 ETLKPKIPVRRMVFHEITEPAIRAAAEDTRDLDNDLVDAQETRRILDRLYGYEVSPVLWK 182 Query 185 KVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLT 244 KV PKLSAGRVQSVATR+IV RER+RMAFRSA YWDI A LDA DA+P F ARL Sbjct 183 KVMPKLSAGRVQSVATRVIVQRERERMAFRSAEYWDISATLDAGA---DASPRAFGARLV 239 Query 245 AVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPY 304 +V G RVA GRDF G L K V V+DE A LA L+G L V+SAE+KPY R+PY Sbjct 240 SVDGSRVAAGRDFGPDGKL-KSTGVTVIDEAYARRLAEALEGVDLVVSSAEDKPYTRKPY 298 Query 305 PPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQ 364 PFMTSTLQQEA+RKLRFS+ERTM +AQRLYENGYITYMRTDSTTLS+SAI+AAR QA + Sbjct 299 APFMTSTLQQEAARKLRFSSERTMRVAQRLYENGYITYMRTDSTTLSQSAISAARAQATE 358 Query 365 LYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIW 424 LYG EYV PRQYTRKVKNAQEAHEAIRPAG+ F TP + L+ D++RLYELIW Sbjct 359 LYGAEYVHATPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLEN---DEYRLYELIW 415 Query 425 QRTVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEA 483 QRTVASQMADARG TL+LRITG +G +E FSA+GRT+TFPGFLKAYVE+VDE GG++ Sbjct 416 QRTVASQMADARGTTLTLRITGTAGTGEECTFSASGRTITFPGFLKAYVESVDEEAGGQS 475 Query 484 DDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKT 543 DDAE RLP LT GQ + +L PDGH+TNPPARYTEASL+KALEELGIGRPSTYSSIIKT Sbjct 476 DDAESRLPVLTQGQEVTATKLDPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKT 535 Query 544 IQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNW 603 I DRGYV+K+GSALVPSWVAFAV GLLE HFGRLVD+DFTAAMED+LDEIA G E+R NW Sbjct 536 ILDRGYVYKRGSALVPSWVAFAVIGLLETHFGRLVDFDFTAAMEDDLDEIAGGREQRGNW 595 Query 604 LNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNG 663 L++FYFG DS+AR+GGLKK+VG NLE IDARE+NSI+LFDD GR ++VRVG+ G Sbjct 596 LSSFYFGDAAAADDSIARAGGLKKMVGQNLEDIDAREINSIRLFDDAEGREVHVRVGRFG 655 Query 664 PYLERLVAG---DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHE 720 PYLER+V G+P QRANL D + PDELT + AE+LF+TPQ+GR LG+DP TGHE Sbjct 656 PYLERMVQNPDDPDGDPVSQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHE 715 Query 721 IVAREGRFGPYVTEILP-------------EPAADAAA------AAQGVKKRQKAAGPKP 761 IVA+EGRFGPYVTEILP E AAD A K +KAAGPKP Sbjct 716 IVAKEGRFGPYVTEILPEPAPEPEPDIVPVEAAADGTTKTKAVKKAPAKKAAKKAAGPKP 775 Query 762 RTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLV 821 RTGSLL+SMDL TVTLEDAL+LLSLPRVVGVDP S EEITAQNGRYGPYLK+G DSRSL Sbjct 776 RTGSLLKSMDLATVTLEDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLE 835 Query 822 TEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDG 881 EDQ+FT+TL+EALKIYAEPKRRGRQ+++A PLRELG D A+GKPMVIKDGRFGPYVTDG Sbjct 836 NEDQMFTVTLEEALKIYAEPKRRGRQASAAAPLRELGNDAATGKPMVIKDGRFGPYVTDG 895 Query 882 ETNASLRKGDDVASITDERAAELLADRRARGP 913 ETNASLRKGD+V SITDERA+ELLADRRARGP Sbjct 896 ETNASLRKGDEVESITDERASELLADRRARGP 927 >gi|326383464|ref|ZP_08205151.1| DNA topoisomerase I subunit omega [Gordonia neofelifaecis NRRL B-59395] gi|326197870|gb|EGD55057.1| DNA topoisomerase I subunit omega [Gordonia neofelifaecis NRRL B-59395] Length=1012 Score = 1305 bits (3376), Expect = 0.0, Method: Compositional matrix adjust. Identities = 672/961 (70%), Positives = 760/961 (80%), Gaps = 75/961 (7%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKARK+A YLG Y+VESSRGHIRDLPR A+DVPAKYK QPWARLGVNVD Sbjct 12 RRLVIVESPTKARKIAGYLGGNYVVESSRGHIRDLPRGAADVPAKYKGQPWARLGVNVDD 71 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 +FEPLY++S +K+STVSEL+ L+KDVDELYLATDGDREGEAIAWHLLETLKP+IPVKRMV Sbjct 72 NFEPLYVVSADKKSTVSELKSLMKDVDELYLATDGDREGEAIAWHLLETLKPKIPVKRMV 131 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITE AIRAAAE+PR+LD+ +VDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQS Sbjct 132 FHEITESAIRAAAENPRELDMPMVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQS 191 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATRIIV RER+RMAF SA YWDI A +DA S A+P TF++RL + RVATGRDF Sbjct 192 VATRIIVERERERMAFVSADYWDIAATMDAGES---ASPRTFASRLVNIGDDRVATGRDF 248 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 + G L+K V VLD+ ATAL+A L+G L+V S EEKPY RRPY PFMTSTLQQEA Sbjct 249 GADGKLKKAAGVTVLDQARATALSAALEGASLSVTSVEEKPYTRRPYAPFMTSTLQQEAG 308 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRFS++RTM IAQRLYENGYITYMRTDSTTLSESAINAAR+QARQLYGD+YV P PRQ Sbjct 309 RKLRFSSDRTMRIAQRLYENGYITYMRTDSTTLSESAINAARSQARQLYGDDYVHPTPRQ 368 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 YTRKVKNAQEAHEAIRPAG++F TP V LD D+FRLYELIWQRTVASQM+DARG Sbjct 369 YTRKVKNAQEAHEAIRPAGDSFRTPGQVASALD---TDEFRLYELIWQRTVASQMSDARG 425 Query 438 MTLSLRITG-MSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPG 496 T+SL+I G S ++V F+++GRT+TFPGFL AYVETVD L GG+ADDAE RLP+L G Sbjct 426 TTMSLKIGGRASTGEQVTFASSGRTITFPGFLSAYVETVDALAGGQADDAENRLPNLREG 485 Query 497 QRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSA 556 Q L LT DGH+TNPPARYTEASLVK LEELGIGRPSTY+SII TIQDRGYV KKGSA Sbjct 486 QALTAASLTADGHSTNPPARYTEASLVKVLEELGIGRPSTYASIIGTIQDRGYVVKKGSA 545 Query 557 LVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFG------ 610 LVPSW+AFAV GLLE +F LVDYDFTA++ED+LD+IA+GN RT WL+ FYFG Sbjct 546 LVPSWIAFAVVGLLEGYFNSLVDYDFTASLEDDLDQIASGNADRTRWLSEFYFGADADAP 605 Query 611 ---GDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLE 667 D ++AR GGLKK+VG+NLEGIDAREVNSIKLFDD+ RP++VRVG+ GPYLE Sbjct 606 DVDDDDDAAGAMARVGGLKKMVGVNLEGIDAREVNSIKLFDDSQDRPVFVRVGRYGPYLE 665 Query 668 RLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGR 727 R VAG EP QRANL +TPDELTL+VAE+LF TPQ+GR LG+DP TGH+IVA+EGR Sbjct 666 RNVAGPDAEPDLQRANLPSDMTPDELTLEVAEKLFETPQEGRVLGVDPATGHQIVAKEGR 725 Query 728 FGPYVTEILPEPAADAAAAAQGVKKRQKA-------AGPKPR------------------ 762 FGPYVTEIL P+ D A G + + AGP PR Sbjct 726 FGPYVTEIL--PSEDDEADKDGGEDPGTSAPVPTIPAGPTPRGGGEEVVALDDVPSGGSG 783 Query 763 -------------------------------TGSLLRSMDLQTVTLEDALRLLSLPRVVG 791 TGSL + M++ TVTL+DAL+LLSLPRVVG Sbjct 784 SVATATSTTTAKKTAKKTAKKAAKKAGPKPRTGSLFKGMEISTVTLDDALKLLSLPRVVG 843 Query 792 VDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASA 851 VDP S EEITAQNGRYGPYLK+G+DSRSL +E+Q+FT+TLDEALKIYAEPKRRGR +A+A Sbjct 844 VDPESKEEITAQNGRYGPYLKKGSDSRSLTSEEQLFTVTLDEALKIYAEPKRRGR-AAAA 902 Query 852 PPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRAR 911 PPLRELG D S KPMVIKDGRFGPYVTDGETNASLRKGD+VA+IT ERA ELLADRRAR Sbjct 903 PPLRELGNDSVSEKPMVIKDGRFGPYVTDGETNASLRKGDEVATITPERAMELLADRRAR 962 Query 912 G 912 G Sbjct 963 G 963 >gi|226304002|ref|YP_002763960.1| DNA topoisomerase I [Rhodococcus erythropolis PR4] gi|226183117|dbj|BAH31221.1| DNA topoisomerase I [Rhodococcus erythropolis PR4] Length=978 Score = 1303 bits (3371), Expect = 0.0, Method: Compositional matrix adjust. Identities = 673/939 (72%), Positives = 762/939 (82%), Gaps = 39/939 (4%) Query 7 KGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQ 66 G G G +G+ RRLVIVESPTKARK+A YLG Y+VE+S GHIRDLPR A+DVPAKYK + Sbjct 6 NGSGQGASGNPRRLVIVESPTKARKIAPYLGKDYVVEASVGHIRDLPRGAADVPAKYKGE 65 Query 67 PWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLET 126 WARLGVNVD DFEPLY++SPEK+ V+EL+ LLKD DEL+LATD DREGEAIAWHLLET Sbjct 66 SWARLGVNVDHDFEPLYVVSPEKKGKVAELKSLLKDADELFLATDPDREGEAIAWHLLET 125 Query 127 LKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKV 186 LKP+IPV+RMVFHEITEPAIRAAAE R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV Sbjct 126 LKPKIPVRRMVFHEITEPAIRAAAEDTRELDTDLVDAQETRRILDRLYGYEVSPVLWKKV 185 Query 187 APKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAV 246 PKLSAGRVQSVATR+IV RER+RMAF+SA+YWDI A LDA +A+P +F ARL +V Sbjct 186 MPKLSAGRVQSVATRVIVQRERERMAFKSASYWDISATLDAGA---EASPRSFGARLVSV 242 Query 247 AGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPP 306 G RVA+GRDF + G L KG V VLDE A LA L G LTV+SAE+KPY R+PYPP Sbjct 243 DGSRVASGRDFGADGKL-KGSAVTVLDEAYARRLAEALQGVDLTVSSAEDKPYTRKPYPP 301 Query 307 FMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLY 366 FMTSTLQQEA RKLRF++ER M IAQRLYENGYITYMRTDSTTLSESAI AAR QA +LY Sbjct 302 FMTSTLQQEAGRKLRFTSERAMRIAQRLYENGYITYMRTDSTTLSESAIAAARAQATELY 361 Query 367 GDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQR 426 G EYV P PRQYTRKVKNAQEAHEAIRPAG+ F TP + +LD D+F+LYELIWQR Sbjct 362 GPEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSKLDS---DEFKLYELIWQR 418 Query 427 TVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADD 485 TVASQMADARG TL+LRI+G +G ++ FSA+GRT+ F GFLKAYVE+VDE GG++DD Sbjct 419 TVASQMADARGTTLTLRISGTAGTGEDCTFSASGRTIVFAGFLKAYVESVDEEAGGQSDD 478 Query 486 AERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQ 545 AE RLP L GQ + +L PDGH+TNPPARYTEASL+K LEELGIGRPSTYSSIIKTI Sbjct 479 AESRLPVLVKGQEVTATKLDPDGHSTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTIL 538 Query 546 DRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLN 605 DRGYV+K+GSALVPSWVAFAV GLLE HFGRLVD+DFTA MED+LD IA G E+R NWL+ Sbjct 539 DRGYVYKRGSALVPSWVAFAVIGLLEVHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLS 598 Query 606 NFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPY 665 +FYFGG+ G SVAR GGLKK+VG+NLE IDAREVNSI+LFDD GR ++VRVG+ GPY Sbjct 599 SFYFGGETGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPY 658 Query 666 LERLVAG---DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIV 722 LER+V G+ QRANL D + PDELT + AE+LF+TPQ+GR LG+DP TGHEIV Sbjct 659 LERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIV 718 Query 723 AREGRFGPYVTEIL----------------PEPAADAAAA------------AQGVKKRQ 754 A+EGRFGPYVTEIL PEP ++ + A K + Sbjct 719 AKEGRFGPYVTEILPEPPAEPEPDIVPVSAPEPEEISSGSTKTAVKKAAAKKAPAKKAAK 778 Query 755 KAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG 814 K AGPKPRTGSLL+SMDL T+TLEDALRLLSLPRVVGVDP S EEITAQNGRYGPYLK+G Sbjct 779 KVAGPKPRTGSLLKSMDLATITLEDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKG 838 Query 815 NDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRF 874 DSRSL E+Q+FT+TLDEALKIYAEPKRRGRQ+++ PPLRELG DP S KPMVIKDGRF Sbjct 839 TDSRSLANEEQMFTVTLDEALKIYAEPKRRGRQASATPPLRELGVDPVSEKPMVIKDGRF 898 Query 875 GPYVTDGETNASLRKGDDVASITDERAAELLADRRARGP 913 GPYVTDGETNASLRK DDV SI+D RA+ELLADRRARGP Sbjct 899 GPYVTDGETNASLRKDDDVESISDARASELLADRRARGP 937 >gi|229494794|ref|ZP_04388550.1| putative DNA topoisomerase I [Rhodococcus erythropolis SK121] gi|229318290|gb|EEN84155.1| putative DNA topoisomerase I [Rhodococcus erythropolis SK121] Length=978 Score = 1302 bits (3370), Expect = 0.0, Method: Compositional matrix adjust. Identities = 673/939 (72%), Positives = 762/939 (82%), Gaps = 39/939 (4%) Query 7 KGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQ 66 G G G +G+ RRLVIVESPTKARK+A YLG Y+VE+S GHIRDLPR A+DVPAKYK + Sbjct 6 NGSGQGASGNPRRLVIVESPTKARKIAPYLGKDYVVEASVGHIRDLPRGAADVPAKYKGE 65 Query 67 PWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLET 126 WARLGVNVD DFEPLY++SPEK+ V+EL+ LLKD DEL+LATD DREGEAIAWHLLET Sbjct 66 SWARLGVNVDHDFEPLYVVSPEKKGKVAELKSLLKDADELFLATDPDREGEAIAWHLLET 125 Query 127 LKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKV 186 LKP+IPV+RMVFHEITEPAIRAAAE R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV Sbjct 126 LKPKIPVRRMVFHEITEPAIRAAAEDTRELDTDLVDAQETRRILDRLYGYEVSPVLWKKV 185 Query 187 APKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAV 246 PKLSAGRVQSVATR+IV RER+RMAF+SA+YWDI A LDA +A+P +F ARL +V Sbjct 186 MPKLSAGRVQSVATRVIVQRERERMAFKSASYWDISATLDAGA---EASPRSFGARLVSV 242 Query 247 AGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPP 306 G RVA+GRDF + G L KG V VLDE A LA L G LTV+SAE+KPY R+PYPP Sbjct 243 DGSRVASGRDFGADGKL-KGSAVTVLDEAYARRLAEALQGVDLTVSSAEDKPYTRKPYPP 301 Query 307 FMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLY 366 FMTSTLQQEA RKLRF++ER M IAQRLYENGYITYMRTDSTTLSESAI AAR QA +LY Sbjct 302 FMTSTLQQEAGRKLRFTSERAMRIAQRLYENGYITYMRTDSTTLSESAIAAARAQATELY 361 Query 367 GDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQR 426 G EYV P PRQYTRKVKNAQEAHEAIRPAG+ F TP + +LD D+F+LYELIWQR Sbjct 362 GPEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSKLDS---DEFKLYELIWQR 418 Query 427 TVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADD 485 TVASQMADARG TL+LRI+G +G ++ FSA+GRT+ F GFLKAYVE+VDE GG++DD Sbjct 419 TVASQMADARGTTLTLRISGTAGTGEDCTFSASGRTIVFAGFLKAYVESVDEEAGGQSDD 478 Query 486 AERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQ 545 AE RLP L GQ + +L PDGH+TNPPARYTEASL+K LEELGIGRPSTYSSIIKTI Sbjct 479 AESRLPVLVKGQEVTATKLDPDGHSTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTIL 538 Query 546 DRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLN 605 DRGYV+K+GSALVPSWVAFAV GLLE HFGRLVD+DFTA MED+LD IA G E+R NWL+ Sbjct 539 DRGYVYKRGSALVPSWVAFAVIGLLEVHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLS 598 Query 606 NFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPY 665 +FYFGG+ G SVAR GGLKK+VG+NLE IDAREVNSI+LFDD GR ++VRVG+ GPY Sbjct 599 SFYFGGETGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPY 658 Query 666 LERLVAG---DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIV 722 LER+V G+ QRANL D + PDELT + AE+LF+TPQ+GR LG+DP TGHEIV Sbjct 659 LERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIV 718 Query 723 AREGRFGPYVTEIL----------------PEPAADAAAA------------AQGVKKRQ 754 A+EGRFGPYVTEIL PEP ++ + A K + Sbjct 719 AKEGRFGPYVTEILPEPPAEPEPDIVPVTAPEPEEISSGSTKTAVKKAAAKKAPAKKAAK 778 Query 755 KAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG 814 K AGPKPRTGSLL+SMDL T+TLEDALRLLSLPRVVGVDP S EEITAQNGRYGPYLK+G Sbjct 779 KVAGPKPRTGSLLKSMDLATITLEDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKG 838 Query 815 NDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRF 874 DSRSL E+Q+FT+TLDEALKIYAEPKRRGRQ+++ PPLRELG DP S KPMVIKDGRF Sbjct 839 TDSRSLANEEQMFTVTLDEALKIYAEPKRRGRQASATPPLRELGVDPVSEKPMVIKDGRF 898 Query 875 GPYVTDGETNASLRKGDDVASITDERAAELLADRRARGP 913 GPYVTDGETNASLRK DDV SI+D RA+ELLADRRARGP Sbjct 899 GPYVTDGETNASLRKDDDVESISDARASELLADRRARGP 937 >gi|256374446|ref|YP_003098106.1| DNA topoisomerase I [Actinosynnema mirum DSM 43827] gi|255918749|gb|ACU34260.1| DNA topoisomerase I [Actinosynnema mirum DSM 43827] Length=923 Score = 1300 bits (3363), Expect = 0.0, Method: Compositional matrix adjust. Identities = 650/913 (72%), Positives = 750/913 (83%), Gaps = 29/913 (3%) Query 5 KTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYK 64 K+ G +GGN RRLVIVESPTKARK+ASYLG+G++VESS+GHIRDLPR A+DVPAKYK Sbjct 9 KSTGGSAGGN---RRLVIVESPTKARKIASYLGNGFVVESSKGHIRDLPRGAADVPAKYK 65 Query 65 SQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLL 124 QPWARLGV+VD DFEPLYI++P+K+STV+EL+ LLK VDELYLATDGDREGEAIAWHLL Sbjct 66 GQPWARLGVDVDHDFEPLYIVTPDKKSTVAELKELLKGVDELYLATDGDREGEAIAWHLL 125 Query 125 ETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWK 184 ETLKP +PV+RMVFHEITEPAI AAA PRDLD+ LVDAQETRRILDRLYGYEVSPVLWK Sbjct 126 ETLKPSVPVRRMVFHEITEPAILAAAASPRDLDLSLVDAQETRRILDRLYGYEVSPVLWK 185 Query 185 KVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLT 244 KV PKLSAGRVQSVATRI+V RER+RM F +A++WD+ A +DA +A P F+ RL Sbjct 186 KVMPKLSAGRVQSVATRIVVERERERMKFVTASFWDVSATIDAGA---EATPRQFAGRLV 242 Query 245 AVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPY 304 +V G R+ATGRDF S G L+ G EV VLDE A A+A GL G + VAS EEKPY R+PY Sbjct 243 SVDGTRLATGRDFGSDGRLKDGVEVKVLDEAHARAIAEGLTGAAMRVASVEEKPYTRKPY 302 Query 305 PPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQ 364 PPFMTST+QQEA RKLRFSA+RTM AQ+LYENGYITYMRTDST LSE+AI AAR QA Sbjct 303 PPFMTSTIQQEAGRKLRFSADRTMRAAQKLYENGYITYMRTDSTALSETAITAARAQATD 362 Query 365 LYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIW 424 LYG +YVA PRQYTRKVKNAQEAHEAIRPAGE F TP V RELD D+++LYELIW Sbjct 363 LYGAQYVAKEPRQYTRKVKNAQEAHEAIRPAGEVFRTPGQVARELDS---DEYKLYELIW 419 Query 425 QRTVASQMADARGMTLSLRITGMS-GHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEA 483 QRT+ASQMADARG T S+R+ G + G ++V+F+++GRT+TF GFLKAYVETVD GG A Sbjct 420 QRTIASQMADARGNTTSVRVAGRTGGGEDVLFASSGRTITFAGFLKAYVETVDSEAGGNA 479 Query 484 DDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKT 543 DDAE RLP L Q + EL+ DGH+T+PP R+TE SL+K +E+LGIGRPSTY+SII T Sbjct 480 DDAESRLPQLVAEQPVSAAELSADGHSTSPPPRFTEPSLIKTMEDLGIGRPSTYASIIST 539 Query 544 IQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNW 603 IQDRGYV KKGSALVPSWVAFAV GLLEQHFGRLVDYDFTAA+EDELD IA G + RT W Sbjct 540 IQDRGYVWKKGSALVPSWVAFAVVGLLEQHFGRLVDYDFTAALEDELDGIAEGRQERTTW 599 Query 604 LNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNG 663 L+ FYFGGD G S+ RSGGLKKLVG ++E IDARE+NSI LF D G + VRVG+ G Sbjct 600 LSGFYFGGDVGPESSIGRSGGLKKLVGSSVEEIDAREINSIPLFSDEGGHTVVVRVGRYG 659 Query 664 PYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVA 723 PYLER V G + QRANL D + PDEL+L++AE+LFATPQ+GR+LG DP TGHEIVA Sbjct 660 PYLEREVDGAS-----QRANLPDDLPPDELSLEIAEKLFATPQEGRSLGNDPATGHEIVA 714 Query 724 REGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRL 783 +EGRFGPYVTE+LPEPA K AG KPRT SL +SM L TVTLEDALRL Sbjct 715 KEGRFGPYVTEVLPEPA------------EGKKAG-KPRTSSLFKSMSLDTVTLEDALRL 761 Query 784 LSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKR 843 LSLPRVVG DP SG EITAQNGRYGPYLKRG DSRSL +EDQ+FT+TLDEALKIYAEPK+ Sbjct 762 LSLPRVVGADPESGAEITAQNGRYGPYLKRGTDSRSLTSEDQLFTVTLDEALKIYAEPKK 821 Query 844 RGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAE 903 RGR +A+APPL+ELG DP SGKPMV+K+GRFGPYVTDGETNASLRK D+V +++DER +E Sbjct 822 RGR-AAAAPPLKELGNDPVSGKPMVVKEGRFGPYVTDGETNASLRKSDNVETLSDERGSE 880 Query 904 LLADRRARGPAKR 916 LLA++RA+GP+ + Sbjct 881 LLAEKRAKGPSTK 893 >gi|226363673|ref|YP_002781455.1| DNA topoisomerase I [Rhodococcus opacus B4] gi|226242162|dbj|BAH52510.1| DNA topoisomerase I [Rhodococcus opacus B4] Length=973 Score = 1300 bits (3363), Expect = 0.0, Method: Compositional matrix adjust. Identities = 679/929 (74%), Positives = 757/929 (82%), Gaps = 33/929 (3%) Query 11 SGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWAR 70 +G +G RRLVIVESPTKARK+A YLG Y+VE+S GHIRDLPR A+DVPAKYK + WAR Sbjct 13 AGASGQPRRLVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWAR 72 Query 71 LGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPR 130 LGVNVD DFEPLY++SPEK+S V+EL+ LLKD DEL+LATD DREGEAIAWHLLETLKP+ Sbjct 73 LGVNVDQDFEPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPK 132 Query 131 IPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKL 190 IPV+RMVFHEITEPAIRAAAE R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV P+L Sbjct 133 IPVRRMVFHEITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRL 192 Query 191 SAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRR 250 SAGRVQSVATR+IV RER+RMAFRSA+YWDI A LDA DA+P +F ARL +V G R Sbjct 193 SAGRVQSVATRVIVQRERERMAFRSASYWDISATLDAGA---DASPRSFGARLVSVDGSR 249 Query 251 VATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTS 310 VATGRDF S G L K V VLDE A LA L G LTV+SAE KPY R+PY PFMTS Sbjct 250 VATGRDFGSDGQL-KTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTS 308 Query 311 TLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEY 370 TLQQEA RKLRF++ERTM IAQRLYENGYITYMRTDSTTLS SAI AAR QA +LYG EY Sbjct 309 TLQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEY 368 Query 371 VAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVAS 430 V PRQYTRKVKNAQEAHEAIRPAG+ F TP + LD D+FRLYELIWQRTVAS Sbjct 369 VHDTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLD---TDEFRLYELIWQRTVAS 425 Query 431 QMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERR 489 QMADARG TL+LRITG +G +E FS++GRT+TF GFLKAYVE+VDE GG++DDAE R Sbjct 426 QMADARGTTLTLRITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESR 485 Query 490 LPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGY 549 LP L GQ + +L PDGH TNPPARYTEASL+K LEELGIGRPSTYSSIIKTI DRGY Sbjct 486 LPVLVEGQAVTATKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGY 545 Query 550 VHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYF 609 V+K+GSALVPSWVAFAV GLLE HFGRLVD+DFTA MED+LD IA G E+R NWL++FYF Sbjct 546 VYKRGSALVPSWVAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYF 605 Query 610 GGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERL 669 GGDHG SVAR GGLKK+VG+NLE IDAREVNSI+LFDD GR ++VRVG+ GPYLER+ Sbjct 606 GGDHGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERM 665 Query 670 VAG---DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREG 726 V G+ QRANL D + PDELT + AE+LF+TPQ+GR LG+DP TGHEIVA+EG Sbjct 666 VQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEG 725 Query 727 RFGPYVTEIL--------------PEPAAD--------AAAAAQGVKKRQKAAGPKPRTG 764 RFGPYVTEIL + + D AA A K +KA GPKPRTG Sbjct 726 RFGPYVTEILPEPEPEPEPAVVPVTDESGDGTTKTKTAAAKKAPAKKAAKKATGPKPRTG 785 Query 765 SLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTED 824 SLL+SMDL TVTL+DAL+LLSLPRVVGVDP S EEITAQNGRYGPYLK+G DSRSL TED Sbjct 786 SLLKSMDLATVTLDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATED 845 Query 825 QIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETN 884 Q+FT+TLDEALKIYAEPKRRGRQ+A+ PPLRELG D S KPMVIKDGRFGPYVTDGETN Sbjct 846 QMFTVTLDEALKIYAEPKRRGRQAAATPPLRELGVDSVSEKPMVIKDGRFGPYVTDGETN 905 Query 885 ASLRKGDDVASITDERAAELLADRRARGP 913 ASLRKGD+V SITD RA+ELLADRRARGP Sbjct 906 ASLRKGDEVESITDARASELLADRRARGP 934 >gi|111021329|ref|YP_704301.1| DNA topoisomerase I [Rhodococcus jostii RHA1] gi|110820859|gb|ABG96143.1| DNA topoisomerase I [Rhodococcus jostii RHA1] Length=973 Score = 1296 bits (3354), Expect = 0.0, Method: Compositional matrix adjust. Identities = 676/929 (73%), Positives = 755/929 (82%), Gaps = 33/929 (3%) Query 11 SGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWAR 70 +G +G RRLVIVESPTKARK+A YLG Y+VE+S GHIRDLPR A+DVPAKYK + WAR Sbjct 13 AGASGQPRRLVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWAR 72 Query 71 LGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPR 130 LGVNVD DFEPLY++SPEK+S V+EL+ LLKD DEL+LATD DREGEAIAWHLLETLKP+ Sbjct 73 LGVNVDHDFEPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPK 132 Query 131 IPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKL 190 IPV+RMVFHEITEPAIRAAAE R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV P+L Sbjct 133 IPVRRMVFHEITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRL 192 Query 191 SAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRR 250 SAGRVQSVATR+IV RER+RMAFRSA+YWDI A LDA DA+P +F ARL +V G R Sbjct 193 SAGRVQSVATRVIVQRERERMAFRSASYWDISATLDAGA---DASPRSFGARLVSVDGSR 249 Query 251 VATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTS 310 VATGRDF + G L K V VLDE A LA L G LTV+SAE KPY R+PY PFMTS Sbjct 250 VATGRDFGADGQL-KTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTS 308 Query 311 TLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEY 370 TLQQEA RKLRF++ERTM IAQRLYENGYITYMRTDSTTLS SAI AAR QA +LYG EY Sbjct 309 TLQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEY 368 Query 371 VAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVAS 430 V PRQYTRKVKNAQEAHEAIRPAG+ F TP + LD D+FRLYELIWQRTVAS Sbjct 369 VHDTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLD---TDEFRLYELIWQRTVAS 425 Query 431 QMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERR 489 QMADARG TL+LRITG +G +E FS++GRT+TF GFLKAYVE+VDE GG++DDAE R Sbjct 426 QMADARGTTLTLRITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESR 485 Query 490 LPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGY 549 LP L GQ + +L PDGH TNPPARYTEASL+K LEELGIGRPSTYSSIIKTI DRGY Sbjct 486 LPVLVEGQAVTATKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGY 545 Query 550 VHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYF 609 V+K+GSALVPSWVAFAV GLLE HFGRLVD+DFTA MED+LD IA G E+R NWL++FYF Sbjct 546 VYKRGSALVPSWVAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYF 605 Query 610 GGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERL 669 GGDHG SVAR GGLKK+VG+NLE IDAREVNSI+LFDD GR ++VRVG+ GPYLER+ Sbjct 606 GGDHGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERM 665 Query 670 VAG---DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREG 726 V G+ QRANL D + PDELT + AE+LF+TPQ+GR LG+DP TGHEIVA+EG Sbjct 666 VQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEG 725 Query 727 RFGPYVTEIL--------------PEPAAD--------AAAAAQGVKKRQKAAGPKPRTG 764 RFGPYVTEIL + + D A A +KA GPKPRTG Sbjct 726 RFGPYVTEILPEPEPEPEPAVVPVTDESGDGTTKTKTAAKKAPAKKAAAKKATGPKPRTG 785 Query 765 SLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTED 824 SLL+SMDL TVTL+DAL+LLSLPRVVGVDP S EEITAQNGRYGPYLK+G DSRSL TED Sbjct 786 SLLKSMDLATVTLDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATED 845 Query 825 QIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETN 884 Q+FT+TLDEALKIYAEPKRRGRQ+A+ PPLRELG D S KPMVIKDGRFGPYVTDGETN Sbjct 846 QMFTVTLDEALKIYAEPKRRGRQAAATPPLRELGVDTVSEKPMVIKDGRFGPYVTDGETN 905 Query 885 ASLRKGDDVASITDERAAELLADRRARGP 913 ASLRKGD+V SITD RA+ELLADRRARGP Sbjct 906 ASLRKGDEVESITDARASELLADRRARGP 934 >gi|257057531|ref|YP_003135363.1| DNA topoisomerase I [Saccharomonospora viridis DSM 43017] gi|256587403|gb|ACU98536.1| DNA topoisomerase I [Saccharomonospora viridis DSM 43017] Length=921 Score = 1284 bits (3323), Expect = 0.0, Method: Compositional matrix adjust. Identities = 650/915 (72%), Positives = 745/915 (82%), Gaps = 17/915 (1%) Query 6 TKGRGSGGNGSGRR-LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYK 64 T+ + +G NG GRR LVIVESPTKARK+A YLGS Y+VESSRGH+RDLPR A+DVPAKYK Sbjct 5 TRTKKTGTNGDGRRRLVIVESPTKARKIAPYLGSDYVVESSRGHVRDLPRGAADVPAKYK 64 Query 65 SQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLL 124 Q WARLGV+VD DFEPLYII+P+K++TVSEL+ LLKDVDELYLATD DREGEAIAWHLL Sbjct 65 GQAWARLGVDVDNDFEPLYIITPDKKATVSELKSLLKDVDELYLATDPDREGEAIAWHLL 124 Query 125 ETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWK 184 E LKP++PV+RMVFHE+TE AIRAAAE+ RDLD++LVDAQETRRILDRLYGYEVSPVLWK Sbjct 125 EALKPKVPVRRMVFHEVTEQAIRAAAENTRDLDLNLVDAQETRRILDRLYGYEVSPVLWK 184 Query 185 KVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLT 244 KV PKLSAGRVQSVATRIIV RER+RM F SA+YWDI A +D +DP+A P +F ARLT Sbjct 185 KVMPKLSAGRVQSVATRIIVERERERMRFTSASYWDIAAVMDVGDADPEATPRSFPARLT 244 Query 245 AVAGRRVATGRDFDSLGTLR-KGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRP 303 V G R+ATGRDF G L+ + +V VLDE A LA L + TV S EEKPY RRP Sbjct 245 MVDGARLATGRDFGPDGRLKEQSQDVRVLDEAEANRLAEALADREFTVVSVEEKPYTRRP 304 Query 304 YPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQAR 363 Y PFMTSTLQQEA RKLRFS+ERTM +AQRLYENGYITYMRTDSTTLSESA+ AAR+QA Sbjct 305 YAPFMTSTLQQEAGRKLRFSSERTMRVAQRLYENGYITYMRTDSTTLSESALAAARSQAT 364 Query 364 QLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELI 423 +LYG EYVA PRQYTRKVKNAQEAHEAIRPAGE F TP AV EL+ D+F+LYELI Sbjct 365 ELYGAEYVADKPRQYTRKVKNAQEAHEAIRPAGEVFRTPGAVAGELES---DEFQLYELI 421 Query 424 WQRTVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGE 482 WQRT+ASQMADA+G T+S++I G + +E VFSA+GRT+TFPGFLKAYVE+VD GGE Sbjct 422 WQRTIASQMADAKGTTMSVKIAGTAASGEECVFSASGRTITFPGFLKAYVESVDTEAGGE 481 Query 483 ADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIK 542 ADD + RLP L Q L EL PD HAT+PP+RY+E SLV LEELGIGRPSTY+SIIK Sbjct 482 ADDKQSRLPRLVKDQSLTATELRPDSHATSPPSRYSEPSLVSKLEELGIGRPSTYASIIK 541 Query 543 TIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTN 602 TIQDRGYV KKGSALVPSWVAF+V GL+E+HF RLVDY FTAAMEDELD IAAG E RT Sbjct 542 TIQDRGYVWKKGSALVPSWVAFSVVGLMERHFERLVDYYFTAAMEDELDRIAAGEEERTE 601 Query 603 WLNNFYFG-GDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGK 661 WL+ FYFG G S+ GGLKKLVG +E IDARE+NSI +F D GR +YVRVG+ Sbjct 602 WLSRFYFGNGKDDDSSSIGSLGGLKKLVGSGVEDIDAREINSIPMFRDNEGRQVYVRVGR 661 Query 662 NGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEI 721 GPYLER V G + QRANL + + PDELT++VAE+LFATPQ+GR LG DPETGHEI Sbjct 662 YGPYLEREVDGQS-----QRANLPEDLPPDELTVEVAEKLFATPQEGRVLGTDPETGHEI 716 Query 722 VAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDAL 781 V +EGRFGPYVTE+LPEP A G K+ K RT SL +SM ++ VTL+DAL Sbjct 717 VVKEGRFGPYVTEVLPEPEESADGKKTGKAKKPKP-----RTASLFKSMSVEDVTLDDAL 771 Query 782 RLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEP 841 +LLSLPRVVG DP +GEEITAQNGRYGPYLK+G+DSRSL +E+QIF ITL+EALKIYAEP Sbjct 772 KLLSLPRVVGTDPETGEEITAQNGRYGPYLKKGSDSRSLSSEEQIFEITLEEALKIYAEP 831 Query 842 KRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERA 901 KRRGRQ+A+ PPL+ELG DP SGKP+V+KDGRFGPYVTDGE NASLRK D V +T ERA Sbjct 832 KRRGRQAAAKPPLKELGEDPVSGKPIVVKDGRFGPYVTDGEYNASLRKSDTVEDLTPERA 891 Query 902 AELLADRRARGPAKR 916 AELLA++RA+GPAK+ Sbjct 892 AELLAEKRAKGPAKK 906 >gi|300790598|ref|YP_003770889.1| DNA topoisomerase IA [Amycolatopsis mediterranei U32] gi|299800112|gb|ADJ50487.1| DNA topoisomerase IA [Amycolatopsis mediterranei U32] gi|340532287|gb|AEK47492.1| DNA topoisomerase I subunit omega [Amycolatopsis mediterranei S699] Length=951 Score = 1266 bits (3277), Expect = 0.0, Method: Compositional matrix adjust. Identities = 643/930 (70%), Positives = 748/930 (81%), Gaps = 17/930 (1%) Query 6 TKGRGSGGNGSG-RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYK 64 K S NG+G RRLVIVESPTKARK+A YLG GY+VESS GHIRDLPR A+DVPA+YK Sbjct 7 NKNGASANNGAGHRRLVIVESPTKARKIAPYLGGGYVVESSVGHIRDLPRGAADVPAQYK 66 Query 65 SQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLL 124 + WARLGV+VD F+ LY+++P+K+S V+EL+ LLKDVDELYLATD DREGEAIAWHLL Sbjct 67 GEAWARLGVDVDNGFKALYVVTPDKKSKVTELKSLLKDVDELYLATDPDREGEAIAWHLL 126 Query 125 ETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWK 184 ETLKP++PV+RMVFHE+TE AIRAAA+ R+LD DLVDAQETRRILDRLYGYEVSPVLWK Sbjct 127 ETLKPKVPVRRMVFHEVTEQAIRAAADSTRELDADLVDAQETRRILDRLYGYEVSPVLWK 186 Query 185 KVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLT 244 KV PKLSAGRVQSVATRI+V RER+RM F SA+YWDI A +DA +A+P F ARL Sbjct 187 KVMPKLSAGRVQSVATRIVVERERERMRFTSASYWDISATMDAG---EEASPRNFPARLV 243 Query 245 AVAGRRVATGRDFDSLGTLR-KGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRP 303 AV G R+ATGRDF S G L+ +EV VL E A LA L V+S EEKPY R+P Sbjct 244 AVDGARLATGRDFGSDGQLKASNNEVRVLAEADARRLADALKQRDFKVSSVEEKPYTRKP 303 Query 304 YPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQAR 363 Y PFMTSTLQQEA RK+RF++ERTM IAQ+LYENGYITYMRTDSTTLSESAI+AAR+QA Sbjct 304 YAPFMTSTLQQEAGRKMRFTSERTMRIAQKLYENGYITYMRTDSTTLSESAISAARSQAT 363 Query 364 QLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELI 423 QLYG EYV+P PRQYTRKVKNAQEAHEAIRP+GE F TP V ELD D+FRLYE+I Sbjct 364 QLYGKEYVSPTPRQYTRKVKNAQEAHEAIRPSGEVFRTPGQVAGELD---TDEFRLYEMI 420 Query 424 WQRTVASQMADARGMTLSLRITG-MSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGE 482 WQRT+ASQMADA+G T+S+RI G + +E F+A+GRT+TF GFLKAYVE VD GGE Sbjct 421 WQRTIASQMADAKGTTMSVRIIGNATSGEECTFAASGRTITFAGFLKAYVEAVDTETGGE 480 Query 483 ADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIK 542 ADD + RLP L Q L EL+PDGH T+PPARY+E SLV LEELGIGRPSTY+SIIK Sbjct 481 ADDKQSRLPVLEKDQALTAAELSPDGHTTSPPARYSEPSLVSKLEELGIGRPSTYASIIK 540 Query 543 TIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTN 602 TIQDRGYV KKGSALVPSWVAFAV GL+E+HF RLVDYDFTA MEDELD IA G+E+R Sbjct 541 TIQDRGYVWKKGSALVPSWVAFAVIGLMERHFERLVDYDFTAGMEDELDRIANGDEQRAQ 600 Query 603 WLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKN 662 WL+ FYFGGD GV S+ R GGLKKLV ++E IDARE+NSI LF D +G + VRVG+ Sbjct 601 WLSKFYFGGDMGVDGSIGRLGGLKKLVEGSVEDIDAREINSIPLFSDENGHTVVVRVGRY 660 Query 663 GPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIV 722 GPYLER V G++ QRANL + + PDELT ++AE+LFATPQ+GRTLG DP +GHEIV Sbjct 661 GPYLEREVDGNS-----QRANLPEDLPPDELTQEIAEKLFATPQEGRTLGTDPVSGHEIV 715 Query 723 AREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALR 782 A+EGRFGPYVTE+LPE A A K + A KPRTGSL +SMD++ +TL+DAL+ Sbjct 716 AKEGRFGPYVTEVLPEIEIPEDATAAQKKAAKAKAP-KPRTGSLFKSMDIENITLDDALK 774 Query 783 LLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPK 842 LLSLPRVVG DP SG+EITAQNGRYGPYLK+G DSRSL TEDQ+F+ITL+EALKIYAEPK Sbjct 775 LLSLPRVVGKDPESGDEITAQNGRYGPYLKKGTDSRSLSTEDQLFSITLEEALKIYAEPK 834 Query 843 RRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAA 902 +RGR + + PPL+ELG DP S KPMV+KDGRFGPYVTDGE NA+LRKGD++ S+T ERA+ Sbjct 835 QRGRSATAKPPLKELGEDPVSKKPMVVKDGRFGPYVTDGEYNATLRKGDEIESLTAERAS 894 Query 903 ELLADRRARGPAKRPARKAARKVPAKKAAK 932 ELLA++RA+GPA P RKA + PA AK Sbjct 895 ELLAEKRAKGPA--PKRKAPARKPASTTAK 922 >gi|302530814|ref|ZP_07283156.1| DNA topoisomerase I [Streptomyces sp. AA4] gi|302439709|gb|EFL11525.1| DNA topoisomerase I [Streptomyces sp. AA4] Length=957 Score = 1263 bits (3268), Expect = 0.0, Method: Compositional matrix adjust. Identities = 645/936 (69%), Positives = 754/936 (81%), Gaps = 16/936 (1%) Query 1 LADPKTKGRGSGGNGSGRR-LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDV 59 +A +TK G+GGNG+ RR LVIVESPTKARK+A YLG Y+VESS GHIRDLPR A+DV Sbjct 1 MAGTRTKKSGTGGNGADRRRLVIVESPTKARKIAPYLGGNYVVESSVGHIRDLPRGAADV 60 Query 60 PAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAI 119 PA+YK + WARLGV++D DF+PLYI++P+K+S V+EL+GLLKDVDELYLATD DREGEAI Sbjct 61 PAQYKGESWARLGVDIDNDFKPLYIVTPDKKSKVTELKGLLKDVDELYLATDPDREGEAI 120 Query 120 AWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVS 179 AWHLLETLKP++PV+RMVFHE+TE AI+AAA R+LD DLVDAQETRRILDRLYGYEVS Sbjct 121 AWHLLETLKPKVPVRRMVFHEVTEQAIQAAAAATRELDADLVDAQETRRILDRLYGYEVS 180 Query 180 PVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTF 239 PVLWKKV PKLSAGRVQSVATRI+V RER+RM F SA+YWDI A +DA DA+P TF Sbjct 181 PVLWKKVMPKLSAGRVQSVATRIVVERERERMRFTSASYWDISATMDAG---EDASPRTF 237 Query 240 SARLTAVAGRRVATGRDFDSLGTLR-KGDEVIVLDEGSATALAAGLDGTQLTVASAEEKP 298 ARL AV G R+ATGRDFDS G L+ ++ VL E A ALA L VAS EEKP Sbjct 238 PARLVAVDGSRLATGRDFDSNGQLKGNAADIRVLGESDARALAQALSERDFKVASVEEKP 297 Query 299 YARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAA 358 Y R+PY PFMTSTLQQEA RKLRF++ERTM IAQ+LYENGYITYMRTDSTTLSESAI AA Sbjct 298 YTRKPYAPFMTSTLQQEAGRKLRFTSERTMRIAQKLYENGYITYMRTDSTTLSESAITAA 357 Query 359 RTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFR 418 R QA QLYG EYV+P+PRQYTRKVKNAQEAHEAIRP+GE F TP V +ELD D+FR Sbjct 358 RNQATQLYGKEYVSPSPRQYTRKVKNAQEAHEAIRPSGEVFRTPGQVAKELD---TDEFR 414 Query 419 LYELIWQRTVASQMADARGMTLSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDE 477 LYE+IWQRT+ASQMADA+G T+S+RI G + +E F+A+GRT+TF GFLKAYVE VD Sbjct 415 LYEMIWQRTIASQMADAKGTTMSVRIVGTAATGEECTFAASGRTITFAGFLKAYVEAVDT 474 Query 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 GGEADD + RLP L Q L EL+ DGH+T+PPARY+E SLV LEELGIGRPSTY Sbjct 475 EAGGEADDKQSRLPVLAKDQALTAPELSADGHSTSPPARYSEPSLVSKLEELGIGRPSTY 534 Query 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 +SIIKTIQDRGYV KKGSALVPSWVAFAV GL+E+HF RLVDY+FTA +EDELD IA G+ Sbjct 535 ASIIKTIQDRGYVWKKGSALVPSWVAFAVVGLMERHFERLVDYNFTAGLEDELDRIANGD 594 Query 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 E R WL+ FYFGGD GV SV R GGLKKLV ++EGIDARE+NSI +F D G + V Sbjct 595 EHRVEWLSKFYFGGDFGVEGSVGRLGGLKKLVDGSVEGIDAREINSIPMFSDAEGHQVVV 654 Query 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 RVG+ GPYLER V G++ QRANL + + PDEL+ ++AE+LFATPQ+GR LG DP + Sbjct 655 RVGRYGPYLEREVNGES-----QRANLPEDLPPDELSPEIAEKLFATPQEGRVLGTDPVS 709 Query 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 GHEIVA+EGRFGPYVTE+LPEP A A K + PKPRTGSL +SM ++T+TL Sbjct 710 GHEIVAKEGRFGPYVTELLPEPELPEDATAAQKKAAKAKL-PKPRTGSLFKSMSIETITL 768 Query 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 +DAL+LLSLPRVVG DP SG+EITAQNGRYGPYLK+G DSRS+ TEDQ+F+ITL+EALKI Sbjct 769 DDALKLLSLPRVVGKDPESGDEITAQNGRYGPYLKKGTDSRSIQTEDQLFSITLEEALKI 828 Query 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Y+EPK+RGR + + PPL+ELG DP SGKPMV+KDGRFGPYVTDGE NA+LRK D + +T Sbjct 829 YSEPKQRGRSATARPPLKELGDDPVSGKPMVVKDGRFGPYVTDGEYNATLRKSDSIEELT 888 Query 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 ERAAELLA++RA+GPA + R RK PAK A + Sbjct 889 AERAAELLAEKRAKGPAPK-KRTTTRKAPAKSTAAK 923 >gi|134096990|ref|YP_001102651.1| DNA topoisomerase I [Saccharopolyspora erythraea NRRL 2338] gi|291006265|ref|ZP_06564238.1| DNA topoisomerase I [Saccharopolyspora erythraea NRRL 2338] gi|133909613|emb|CAL99725.1| DNA topoisomerase I [Saccharopolyspora erythraea NRRL 2338] Length=922 Score = 1261 bits (3264), Expect = 0.0, Method: Compositional matrix adjust. Identities = 631/891 (71%), Positives = 737/891 (83%), Gaps = 30/891 (3%) Query 20 LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADF 79 +VIVESP KARK+ASYLGS ++VESSRGHIRDLP A+DVPAKYK QPWARLGV+VD DF Sbjct 1 MVIVESPAKARKIASYLGSNFVVESSRGHIRDLPSGAADVPAKYKGQPWARLGVDVDNDF 60 Query 80 EPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFH 139 EPLY+++P+K++TV+EL+ LK+VDELYLATDGDREGEAIAWHL+ETLKP++PV+RMVFH Sbjct 61 EPLYLVTPDKKATVTELKDALKEVDELYLATDGDREGEAIAWHLMETLKPKVPVRRMVFH 120 Query 140 EITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 199 EITE AI++AA +PR+LD DLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct 121 EITESAIQSAAANPRELDRDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 180 Query 200 TRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDS 259 TRI+V RER+R+ F A YWDI A +DA PDA P F ARL +V G ++ATGRDF Sbjct 181 TRIVVERERERIKFVPAEYWDISATMDAG---PDAEPRRFGARLVSVDGAKLATGRDFGP 237 Query 260 LGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRK 319 G L K D+V +L+E A LA GL +L+V+S EEKPY R+PY PFMTSTLQQEASRK Sbjct 238 DGRL-KNDDVRLLNEAEARRLATGLTDARLSVSSVEEKPYTRKPYAPFMTSTLQQEASRK 296 Query 320 LRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYT 379 LRFSA+RTM AQRLYENGYITYMRTDSTTLSE+AI AAR QAR LYGDEY++P PRQY Sbjct 297 LRFSADRTMRTAQRLYENGYITYMRTDSTTLSETAITAARNQARDLYGDEYLSPQPRQYN 356 Query 380 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMT 439 RKVKNAQEAHEAIRPAGE+F TP V ELD D ++LYELIWQRT+ASQMADA+G T Sbjct 357 RKVKNAQEAHEAIRPAGESFRTPGQVAAELD---TDGYKLYELIWQRTIASQMADAKGTT 413 Query 440 LSLRITGMSGH-QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQR 498 LS+RITG S +E F+A+GRT+TF GFLKAYVE VD GG ADDAE RLP L Q Sbjct 414 LSVRITGTSADGEECTFAASGRTITFAGFLKAYVEAVDSEAGGVADDAESRLPRLAQYQA 473 Query 499 LDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALV 558 + EL+PDGH+TNPP RYTEASLVKALEELGIGRPSTY+SII T+QDRGYV KKGSALV Sbjct 474 VTAPELSPDGHSTNPPPRYTEASLVKALEELGIGRPSTYASIISTVQDRGYVWKKGSALV 533 Query 559 PSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDS 618 PSWVAFAV GL+E+HFGRLVDYDFTAA+EDELD IA G ++RT WL+ FYFGG+ G DS Sbjct 534 PSWVAFAVVGLMEKHFGRLVDYDFTAALEDELDRIAEGRQQRTKWLSGFYFGGEVGPDDS 593 Query 619 VARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPT 678 + R+GGLKKLVG ++E IDAREVNSI +F D GR +YVRVG+ GPYLER ++ + Sbjct 594 IGRAGGLKKLVGSSVEEIDAREVNSIPMFTDDDGRTVYVRVGRYGPYLERPLS----DSE 649 Query 679 PQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPE 738 QRANL D + PDEL +Q+AE+LFATP +GR+LG DPETGHE++A+EGRFGPYVTE+LPE Sbjct 650 SQRANLPDDLPPDELDIQIAEKLFATPMEGRSLGTDPETGHEVLAKEGRFGPYVTEVLPE 709 Query 739 PAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGE 798 ++G KPRTGSLL+SM L TVT++DAL+LL+LPRVVG DP SG Sbjct 710 -------GSKG----------KPRTGSLLKSMSLDTVTIDDALKLLALPRVVGTDPESGT 752 Query 799 EITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELG 858 EITAQNGR+GPYLKRG+DSRSL TE+QIFT+TL+EALK+YA+PK+RGR++A+A PLRELG Sbjct 753 EITAQNGRFGPYLKRGSDSRSLDTEEQIFTVTLEEALKLYAQPKQRGRRAAAA-PLRELG 811 Query 859 TDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRR 909 DP SGKP+VIKDGRFGPYVTDGETNASLRKGD V +T +RA EL+A+RR Sbjct 812 DDPDSGKPLVIKDGRFGPYVTDGETNASLRKGDSVEELTIDRAVELIAERR 862 >gi|296394983|ref|YP_003659867.1| DNA topoisomerase I [Segniliparus rotundus DSM 44985] gi|296182130|gb|ADG99036.1| DNA topoisomerase I [Segniliparus rotundus DSM 44985] Length=943 Score = 1240 bits (3208), Expect = 0.0, Method: Compositional matrix adjust. Identities = 628/916 (69%), Positives = 732/916 (80%), Gaps = 19/916 (2%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKARKLAS+LG Y+VESSRGHIRDLPR +D+PAKYKS+PWARLGVNV+A Sbjct 22 RRLVIVESPTKARKLASFLGGEYVVESSRGHIRDLPRGTADIPAKYKSEPWARLGVNVEA 81 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 DF+PLY++SPEK++TV+EL+ LKDVDELYLATDGDREGEAIAWHLL+TLKP++PV+RMV Sbjct 82 DFDPLYVVSPEKKATVTELKDKLKDVDELYLATDGDREGEAIAWHLLQTLKPKVPVRRMV 141 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITEPAI AAA +PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQS Sbjct 142 FHEITEPAILAAAANPRDLDTDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQS 201 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATRIIV RER+RMAFRSA+YWD+ + P FSA+L + G RVA+GRDF Sbjct 202 VATRIIVQRERERMAFRSASYWDLSVTVGTE--------PEFSAKLVELDGLRVASGRDF 253 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 G D V ++ E A ALA L G QL VA EKPY+R+PYPPFMTSTLQQEAS Sbjct 254 TPQGEPANPDRVHIVGEAEARALAEALVGAQLDVADVAEKPYSRKPYPPFMTSTLQQEAS 313 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRFS +RTM IAQRLYENG+ITYMRTDS TLS+ A AAR+QA L+G + V APRQ Sbjct 314 RKLRFSTDRTMRIAQRLYENGHITYMRTDSVTLSQQATEAARSQAAALFGSDSVPKAPRQ 373 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 Y K KNAQEAHEAIRPAG++F P+ + + LD D+ RLYELIW+RTVASQM DARG Sbjct 374 YASKAKNAQEAHEAIRPAGDSFVRPEQLAQALDQ---DELRLYELIWRRTVASQMVDARG 430 Query 438 MTLSLRITGMSGH-----QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPH 492 + SLR+ + ++ VF+A+G +T PGFL+AYVETVDEL GGEADDA+R LP Sbjct 431 TSTSLRLATTTTAGTASARDCVFAASGLVITNPGFLRAYVETVDELAGGEADDAQRHLPQ 490 Query 493 LTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHK 552 L GQ++ E P HAT+PPARYTEASLVKALE+LGIGRPSTYSSII TIQ+RGYV+K Sbjct 491 LAKGQQVAAREAAPAEHATSPPARYTEASLVKALEDLGIGRPSTYSSIIDTIQERGYVYK 550 Query 553 KGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGD 612 KG+ALVP+WVAFAV GLLE +F LVDY+FTA MEDELD IAAG E RT WLN FY+G + Sbjct 551 KGAALVPAWVAFAVVGLLEAYFDPLVDYEFTAHMEDELDAIAAGREHRTPWLNRFYYGDE 610 Query 613 HGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAG 672 +G SVAR+GGLK+LVG N E IDAREVNSI +F+D+ R ++VRVGK GPYLER+V Sbjct 611 NGPVRSVARAGGLKRLVGANAETIDAREVNSIPVFEDSEARQVWVRVGKFGPYLERMVKD 670 Query 673 DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYV 732 D GE QRANL +TPDELT ++AE+LFATP +GR LG DP++GHEIV +EGRFGPYV Sbjct 671 DQGELVSQRANLQQGLTPDELTPELAEQLFATPSEGRVLGFDPQSGHEIVVKEGRFGPYV 730 Query 733 TEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGV 792 TE+LP K + AA PKPRT SL +SM ++VTLEDA+RLLSLPR VG Sbjct 731 TEVLPPAVVAQQEEKAKAKGGKNAAAPKPRTASLFKSMTPESVTLEDAVRLLSLPRTVGS 790 Query 793 DPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAP 852 DP +GEEITAQNG++GPYLKRG+DSRSL E+Q+FT+TLDEAL +YAEPKRRG Q A+A Sbjct 791 DPNTGEEITAQNGKFGPYLKRGSDSRSLANEEQLFTVTLDEALALYAEPKRRGAQ-AAAG 849 Query 853 PLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARG 912 PLRELG DP SG PMV+K GRFGPYVTDG TNASLRKGD+V S+TDERAAELLA+RRA G Sbjct 850 PLRELGVDPVSGVPMVVKSGRFGPYVTDGTTNASLRKGDEVESLTDERAAELLAERRAAG 909 Query 913 PAKRPARKAARKVPAK 928 PAK+ + AAR+ PAK Sbjct 910 PAKK--KPAARRTPAK 923 >gi|296141547|ref|YP_003648790.1| DNA topoisomerase I [Tsukamurella paurometabola DSM 20162] gi|296029681|gb|ADG80451.1| DNA topoisomerase I [Tsukamurella paurometabola DSM 20162] Length=968 Score = 1238 bits (3204), Expect = 0.0, Method: Compositional matrix adjust. Identities = 647/918 (71%), Positives = 729/918 (80%), Gaps = 20/918 (2%) Query 9 RGSGGNGSG-RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQP 67 RG +G G +RLVIVESP K +K+ +LG Y V +S GHIRDLP + +P + + Sbjct 4 RGKAADGDGLQRLVIVESPAKGKKIGDFLGPNYTVRASMGHIRDLPSRDNPLPEADQGKS 63 Query 68 WARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETL 127 W+RLGV+VD DFE Y+ S KRSTVSEL+ LLK DELYLATDGDREGEAIAWHL E L Sbjct 64 WSRLGVDVDHDFEAHYVTSASKRSTVSELKSLLKQADELYLATDGDREGEAIAWHLQEVL 123 Query 128 KPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVA 187 KP++PVKRMVFHEIT+ AI+AAA+ PR+LD++LVDAQETRRILDRLYGYEVSPVLW+KV Sbjct 124 KPKVPVKRMVFHEITQQAIQAAAQEPRELDMNLVDAQETRRILDRLYGYEVSPVLWRKVN 183 Query 188 PKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVA 247 LSAGRVQSVATRIIV RER+R+AFR+A YWDI A+LDA +A+P TF ARL +V Sbjct 184 QGLSAGRVQSVATRIIVDRERERIAFRTAGYWDIAAQLDAGA---EASPRTFGARLVSVD 240 Query 248 GRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPF 307 G RVATGRDFD+ G L+K + VLD A AL AGL G L V S EEKPY R+PY PF Sbjct 241 GDRVATGRDFDAQGQLKKPTGITVLDGTRANALVAGLQGANLAVTSVEEKPYTRKPYAPF 300 Query 308 MTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYG 367 MTSTLQQEASRKLRF+ +RTM IAQRLYE GYITYMRTDSTTLSE+AI AAR QARQLYG Sbjct 301 MTSTLQQEASRKLRFNTDRTMQIAQRLYEGGYITYMRTDSTTLSETAIAAARDQARQLYG 360 Query 368 DEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRT 427 ++V P PRQYTRKVKNAQEAHEAIRPAGETF TP A+ L N D+FRLYELIWQRT Sbjct 361 ADFVHPTPRQYTRKVKNAQEAHEAIRPAGETFQTPGALASVL---NSDEFRLYELIWQRT 417 Query 428 VASQMADARGMTLSLRITGMSGHQEVV-FSATGRTLTFPGFLKAYVETVDELVGGEADDA 486 VASQMAD +G TLSLRI G + E V F+A+GRT+TFPGFL AYVETVDE GGEADDA Sbjct 418 VASQMADVKGTTLSLRIGGTASSGESVEFAASGRTITFPGFLSAYVETVDEQAGGEADDA 477 Query 487 ERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQD 546 E RLP LT GQR+ ELT H T+PPARYTEASLVK LEELGIGRPSTY+SIIKTIQD Sbjct 478 ESRLPQLTKGQRVTAAELTAADHVTSPPARYTEASLVKTLEELGIGRPSTYASIIKTIQD 537 Query 547 RGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNN 606 RGYV KKG+ALVP WVAFAV GLLE HFG LVDY+FTA+MED+LDEIA G E R +WL Sbjct 538 RGYVVKKGNALVPQWVAFAVIGLLEGHFGGLVDYNFTASMEDDLDEIAGGREGRVDWLTR 597 Query 607 FYF-----GGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGK 661 FYF S GLK LV NL+ IDARE+NSI L+ DT G +YVRVG+ Sbjct 598 FYFGDAGDAAAAAADGPGPDSPGLKNLVAANLDAIDAREINSIPLYTDTDGNVVYVRVGR 657 Query 662 NGPYLERLVAGDTGEPTP--QRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGH 719 GPYLER VA GE P QRAN+ S+TPDELT +VAE+LFATPQ GR LG+DP TGH Sbjct 658 YGPYLERTVAPKDGETEPQVQRANILASMTPDELTEEVAEKLFATPQDGRPLGVDPATGH 717 Query 720 EIVAREGRFGPYVTEILPEPAADAAA-----AAQGVKKRQKAAGPKPRTGSLLRSMDLQT 774 EIVA+EGRFGPYVTEILPEP D AA K+++K PKPRTGSLL+SMD++T Sbjct 718 EIVAKEGRFGPYVTEILPEPETDDDTENLDEAAAKPKRKKKTDAPKPRTGSLLKSMDIET 777 Query 775 VTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEA 834 VTL+DALRLLSLPRVVGVDP S EEITAQNGRYGPYLK+G DSRSL TE+Q+FT+TL+EA Sbjct 778 VTLDDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEEQMFTVTLEEA 837 Query 835 LKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVA 894 LK+YAEPKRRGR +A+APPLRELG DP SG MVIKDGRFGPYVTDGETNASLRKGD+VA Sbjct 838 LKLYAEPKRRGRGAAAAPPLRELGNDPVSGNAMVIKDGRFGPYVTDGETNASLRKGDEVA 897 Query 895 SITDERAAELLADRRARG 912 SITDERA+ELLADRRARG Sbjct 898 SITDERASELLADRRARG 915 >gi|325002272|ref|ZP_08123384.1| DNA topoisomerase I subunit omega [Pseudonocardia sp. P1] Length=932 Score = 1228 bits (3178), Expect = 0.0, Method: Compositional matrix adjust. Identities = 626/898 (70%), Positives = 732/898 (82%), Gaps = 29/898 (3%) Query 21 VIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFE 80 +IVESP+KA+K+ YLG+ Y+VESS GHIRDLPR A+DVPAKYK + WARLGV+VD F Sbjct 1 MIVESPSKAKKIQPYLGNDYVVESSVGHIRDLPRGAADVPAKYKGESWARLGVDVDNQFS 60 Query 81 PLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHE 140 PLYI++PEK+STVSELR LK VDEL LATD DREGEAIAWHLLETLKP++PV+RMVFHE Sbjct 61 PLYIVTPEKKSTVSELREALKTVDELLLATDPDREGEAIAWHLLETLKPKVPVRRMVFHE 120 Query 141 ITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVAT 200 ITE AIRAAAE+ R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSV T Sbjct 121 ITESAIRAAAENTRELDQDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVVT 180 Query 201 RIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSL 260 R++V RERDR+AFRSA YWDI A LDA +A P TF ARL V RRVATGRDFDSL Sbjct 181 RLVVQRERDRIAFRSAEYWDISATLDAGA---EATPRTFGARLVQVDERRVATGRDFDSL 237 Query 261 GTLRKGDE-----VIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQE 315 G L+K + V+VL+E A LA GL+G LTV S E KPY R+PY PF TSTLQQE Sbjct 238 GQLKKAAQNNSADVVVLNEAEARRLAEGLEGRNLTVDSVESKPYTRKPYAPFTTSTLQQE 297 Query 316 ASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAP 375 A RKLRFS+ERTM AQRLYENGYITYMRTDSTTLS++AI AAR QAR+LYGD YVA P Sbjct 298 AGRKLRFSSERTMRSAQRLYENGYITYMRTDSTTLSDAAIQAARAQARELYGDAYVADKP 357 Query 376 RQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADA 435 RQYTRKVKNAQEAHEAIRPAGE+F TP A+ RE+DG DDFRLYEL+WQRT+ASQM DA Sbjct 358 RQYTRKVKNAQEAHEAIRPAGESFRTPGAIAREVDG---DDFRLYELVWQRTIASQMNDA 414 Query 436 RGMTLSLRITGMSGHQE-VVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLT 494 RG T+S+RI G +G E VVF+++GRT+TFPGFLKAYVETVD+ +ADDAE RLP LT Sbjct 415 RGTTVSVRIGGTAGTGEKVVFASSGRTITFPGFLKAYVETVDDGSKEQADDAESRLPELT 474 Query 495 PGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKG 554 GQ L ELTPDGH+T+PP+RYTE +LVK +EELGIGRPSTY+S IKTI DRGYV KKG Sbjct 475 EGQALTADELTPDGHSTSPPSRYTEPALVKVMEELGIGRPSTYASTIKTILDRGYVWKKG 534 Query 555 SALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHG 614 SALVPSWVAFAV GL+EQHFG+LVDYDFTA MED+LD IA+GN+ R +WL+ FYFG + Sbjct 535 SALVPSWVAFAVVGLMEQHFGQLVDYDFTAEMEDDLDSIASGNDSRVHWLSGFYFGSEDA 594 Query 615 VPD----SVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLV 670 PD +A++GGLKKLVG NLE IDAR VNSI +F D GR + VRVG+ GPYLER+V Sbjct 595 APDDTGSEIAKAGGLKKLVGSNLEEIDARTVNSIVMFADAAGRDVVVRVGRYGPYLERIV 654 Query 671 AGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGP 730 G++ QRANL+D + PDELT ++AE+LF+ PQ+GR LG DP TGHE+VA+EGRFGP Sbjct 655 DGES-----QRANLTDGLPPDELTEEIAEKLFSVPQEGRKLGTDPVTGHEVVAKEGRFGP 709 Query 731 YVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVV 790 YVTE+LPEP A + K + RTGSL ++M + T+TL++AL+LLSLPRVV Sbjct 710 YVTELLPEPEVPEGAKKKPAKPKP-------RTGSLFKTMSVDTITLDEALKLLSLPRVV 762 Query 791 GVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGR-QSA 849 G DP SG+EITAQNGRYGPYLK+G DSRSL E+Q+FT+TL+EAL++Y +PK+RGR + A Sbjct 763 GNDPESGDEITAQNGRYGPYLKKGTDSRSLADEEQLFTVTLEEALELYKQPKQRGRGRGA 822 Query 850 SAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLAD 907 + PPLRELG DP++ K MVIKDGRFGPYVTDGETNASLRKGD+V ++TDERA+ELLA+ Sbjct 823 AQPPLRELGEDPSTSKKMVIKDGRFGPYVTDGETNASLRKGDEVEALTDERASELLAE 880 Score = 81.3 bits (199), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 67/228 (30%), Positives = 101/228 (45%), Gaps = 59/228 (25%) Query 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 G ++V R GR+GPY+ I+ G +R +L + +T Sbjct 636 GRDVVVRVGRYGPYLERIV-----------DGESQR----------ANLTDGLPPDELTE 674 Query 778 EDALRLLSLP---RVVGVDPASGEEITAQNGRYGPYLKR------------------GND 816 E A +L S+P R +G DP +G E+ A+ GR+GPY+ Sbjct 675 EIAEKLFSVPQEGRKLGTDPVTGHEVVAKEGRFGPYVTELLPEPEVPEGAKKKPAKPKPR 734 Query 817 SRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGP 876 + SL + TITLDEALK+ + P R +G DP SG + ++GR+GP Sbjct 735 TGSLFKTMSVDTITLDEALKLLSLP-------------RVVGNDPESGDEITAQNGRYGP 781 Query 877 YVTDGETNASLRKGDDVASITDERAAELLAD----RRARGPAKRPARK 920 Y+ G + SL + + ++T E A EL R RG A+ P R+ Sbjct 782 YLKKGTDSRSLADEEQLFTVTLEEALELYKQPKQRGRGRGAAQPPLRE 829 >gi|258650985|ref|YP_003200141.1| DNA topoisomerase I [Nakamurella multipartita DSM 44233] gi|258554210|gb|ACV77152.1| DNA topoisomerase I [Nakamurella multipartita DSM 44233] Length=978 Score = 1218 bits (3151), Expect = 0.0, Method: Compositional matrix adjust. Identities = 634/916 (70%), Positives = 726/916 (80%), Gaps = 16/916 (1%) Query 14 NGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGV 73 NG G RLV+VESP+KA+ ++ YLG GYIVESS GHIRDLPR A+DVPAKYK +PWARLGV Sbjct 11 NG-GVRLVVVESPSKAKTISGYLGDGYIVESSVGHIRDLPRGAADVPAKYKGEPWARLGV 69 Query 74 NVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPV 133 + + FEPLY++SPEK++ V++L+ LL DELYLATD DREGEAIAWHLLETLKP++PV Sbjct 70 DTEHGFEPLYVVSPEKKAQVAKLKSLLAGADELYLATDEDREGEAIAWHLLETLKPKVPV 129 Query 134 KRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAG 193 KRMVFHEIT AIR AA +PR LD +LVDAQETRRILDRLYGYEVSPVLWKKV PKLSAG Sbjct 130 KRMVFHEITPAAIREAAANPRALDENLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAG 189 Query 194 RVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVAT 253 RVQSVATRIIV RER+RMAFRS YW LDA +S F + L+ V GRR+A Sbjct 190 RVQSVATRIIVQRERERMAFRSGTYWG----LDALMSPAGTGAEPFKSALSTVDGRRLAA 245 Query 254 GRDFD-SLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTL 312 GRDFD + G L+ +V++LDE A LA L G TV S EEKPY R+PYPPFMTSTL Sbjct 246 GRDFDPATGGLKADADVLLLDEDGARTLATALAGGTATVTSVEEKPYTRKPYPPFMTSTL 305 Query 313 QQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVA 372 QQEA RKL F++ERTM AQRLYENG+ITYMRTDSTTLS SA AAR QAR+LYG EYV Sbjct 306 QQEAGRKLGFNSERTMRTAQRLYENGFITYMRTDSTTLSSSAQEAARAQARELYGPEYVP 365 Query 373 PAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQM 432 P PRQYTRKVKNAQEAHEAIRPAG+ F TP V ++ G D++RLYELIWQRT+ASQM Sbjct 366 PTPRQYTRKVKNAQEAHEAIRPAGDNFRTPGQVANQISG---DEYRLYELIWQRTIASQM 422 Query 433 ADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPH 492 DARG+TLS++I + QE VFSA+GRT+TFPGFL+AYVETVD GGEADDAERRLP Sbjct 423 VDARGLTLSVKIAATAREQECVFSASGRTITFPGFLRAYVETVDAEAGGEADDAERRLPK 482 Query 493 LTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHK 552 L GQ+LDI +L P H T PPARYTE SL+ AL++LGIGRPSTY+SII+TI DRGYV K Sbjct 483 LETGQKLDIRDLIPASHVTTPPARYTEPSLIGALQDLGIGRPSTYTSIIRTIIDRGYVWK 542 Query 553 KGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGD 612 KG ALVPSW+AFAV GLLEQHF RLVDY+FTAAMEDELD IA G RT+WL+ FYFGGD Sbjct 543 KGQALVPSWIAFAVIGLLEQHFSRLVDYNFTAAMEDELDGIADGRIGRTDWLSAFYFGGD 602 Query 613 HGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAG 672 G SV RSGGLKKLVG LE IDAREVNS+ L D GR + VRVG+ GPYLER+V G Sbjct 603 LGPAGSVGRSGGLKKLVGERLEDIDAREVNSLPLLTDAEGRQVLVRVGRYGPYLERMVQG 662 Query 673 DTGEPTPQRANLSDSITPDELTLQVAEELFATPQQG--RTLGLDPETGHEIVAREGRFGP 730 + GEPT QRANL + + PDE+ +VAE+LF+ G LG+DP+TGH IVA++GRFGP Sbjct 663 EDGEPTAQRANLPEDLPPDEVDAEVAEKLFSQSGDGGETELGVDPDTGHLIVAKDGRFGP 722 Query 731 YVTEILPEPAADAAAAAQG--VKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPR 788 YVTE+LPE AA AA A G K + A KPRT SL +SM L T+ L ALRLLSLPR Sbjct 723 YVTEVLPE-AAPAATGADGTAKKTTKAKAAAKPRTASLFKSMTLDTIDLPTALRLLSLPR 781 Query 789 VVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQS 848 VVGVDPA G+EITAQNGRYGPYLK+G DSRSL +ED +F +TLDEAL +YA+PK RGR + Sbjct 782 VVGVDPADGQEITAQNGRYGPYLKKGTDSRSLTSEDALFDVTLDEALALYAQPKTRGRSA 841 Query 849 ASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADR 908 A+APPLRE+G DP+ GKPMVIKDGRFGPYVTDGETNASLRKGD+V ++T ERAAELLADR Sbjct 842 AAAPPLREVGIDPSGGKPMVIKDGRFGPYVTDGETNASLRKGDEVETLTVERAAELLADR 901 Query 909 RARGPAKRPARKAARK 924 RARGPA P R RK Sbjct 902 RARGPA--PKRATTRK 915 >gi|317508883|ref|ZP_07966522.1| DNA topoisomerase I [Segniliparus rugosus ATCC BAA-974] gi|316252844|gb|EFV12275.1| DNA topoisomerase I [Segniliparus rugosus ATCC BAA-974] Length=942 Score = 1217 bits (3150), Expect = 0.0, Method: Compositional matrix adjust. Identities = 629/920 (69%), Positives = 735/920 (80%), Gaps = 19/920 (2%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 RRLVIVESPTKARKL+S+LG Y+VESSRGHIRDLPR +D+PAKYK++PWARLGVNV+A Sbjct 25 RRLVIVESPTKARKLSSFLGGNYVVESSRGHIRDLPRGTADIPAKYKTEPWARLGVNVEA 84 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 DF+PLY++SPEK++TV+EL+ LK VDELYLATDGDREGEAIAWHLLETLKP++PV+RMV Sbjct 85 DFDPLYVVSPEKKATVTELKDKLKTVDELYLATDGDREGEAIAWHLLETLKPKVPVRRMV 144 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEITEPAI AAA +PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQS Sbjct 145 FHEITEPAILAAAANPRDLDTDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQS 204 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATRIIV RER+RMAFRSA+YWD+ + A+ P F+A+L + G RVA+GRDF Sbjct 205 VATRIIVQRERERMAFRSASYWDLSVTV--------ASDPEFTAKLVELDGLRVASGRDF 256 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 G D V ++ E A ALA L G QL V EKPY+RRPYPPFMTSTLQQEAS Sbjct 257 TPQGEPANPDRVRIVGEAEARALAEALVGAQLDVVDVAEKPYSRRPYPPFMTSTLQQEAS 316 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRFS +RTM +AQRLYENG+ITYMRTDS TLS+ A AAR+QA L+G + V APRQ Sbjct 317 RKLRFSTDRTMRLAQRLYENGHITYMRTDSVTLSQQATEAARSQATALFGADAVPKAPRQ 376 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 Y K KNAQEAHEAIRPAG++FA P+ + LD D+ RLYELIW+RTVASQM DARG Sbjct 377 YASKAKNAQEAHEAIRPAGDSFARPEQLAGTLDS---DELRLYELIWRRTVASQMVDARG 433 Query 438 MTLSLRITGMSGH----QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHL 493 + SLR+ + ++ VF+A+G +T GFL+AYVETVDEL GGEADDA+R LP L Sbjct 434 TSTSLRLATTTTANGAARDCVFAASGLVITTQGFLRAYVETVDELAGGEADDAQRHLPQL 493 Query 494 TPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKK 553 T GQ + E P HAT+PPARYTEASLVKALE+LGIGRPSTY++II TIQ+RGYV++K Sbjct 494 TKGQHVPAREAAPAEHATSPPARYTEASLVKALEDLGIGRPSTYAAIIDTIQERGYVYRK 553 Query 554 GSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDH 613 G+ALVP+WVAFAV GLLE +F LVDY+FTA MEDELD IAAG E RT WLN FY+G + Sbjct 554 GAALVPAWVAFAVVGLLEAYFDPLVDYEFTAHMEDELDAIAAGREHRTPWLNRFYYGDQN 613 Query 614 GVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGD 673 G SVAR+GGLK+LVG N E IDAREVNSI +F+D+ GR I+VRVG+ GPYLER+V D Sbjct 614 GPARSVARAGGLKRLVGANAETIDAREVNSIPVFEDSEGRQIWVRVGRFGPYLERMVKDD 673 Query 674 TGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVT 733 GE QRANL +TPDELT +VAE+LFATP +GR LG DP++GHEIV +EGRFGPYVT Sbjct 674 HGELVSQRANLHQDLTPDELTPEVAEQLFATPSEGRLLGFDPQSGHEIVVKEGRFGPYVT 733 Query 734 EILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVD 793 E+LP PA +A + K +KAA PKPRT SL +SMD + VTL+DA+RLLSLPR VGVD Sbjct 734 ELLP-PAVEAQQEEKAKAKGKKAAAPKPRTASLFKSMDPEQVTLDDAVRLLSLPRTVGVD 792 Query 794 PASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPP 853 P + EEITAQNG++GPYLKRG DSRSL E+Q+FTITL EAL +YAEPKRRG Q A+A P Sbjct 793 PNTDEEITAQNGKFGPYLKRGTDSRSLANEEQLFTITLQEALALYAEPKRRGAQ-AAAGP 851 Query 854 LRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGP 913 LRELGTDP SG MV+K GRFGPYVTDG TNASLRKGD+V ++TDERA+ELLADRRA GP Sbjct 852 LRELGTDPVSGAAMVVKSGRFGPYVTDGTTNASLRKGDEVETLTDERASELLADRRAAGP 911 Query 914 AKRPARKAARKVPAKKAAKR 933 AK+PA + R P A KR Sbjct 912 AKKPASR--RAAPKSAATKR 929 >gi|336326561|ref|YP_004606527.1| DNA topoisomerase I [Corynebacterium resistens DSM 45100] gi|336102543|gb|AEI10363.1| DNA topoisomerase I [Corynebacterium resistens DSM 45100] Length=1007 Score = 1173 bits (3034), Expect = 0.0, Method: Compositional matrix adjust. Identities = 607/952 (64%), Positives = 717/952 (76%), Gaps = 60/952 (6%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 +RLVIVES TKARK+A YLG YIVE+S GHIRDLPR A+DVPAKYK +PWARLGVNVD Sbjct 7 KRLVIVESATKARKIAPYLGPNYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDK 66 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 +FEPLY++S +K+ VS+L+ LK VDELYLATD DREGEAIAWHLLE LKP++PV+RMV Sbjct 67 EFEPLYVVSADKKKKVSDLKAKLKQVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMV 126 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEIT+PAI AAAE R+LD DLVDAQE RR+LDRLYGYEVSPVLWKKV P+LSAGRVQS Sbjct 127 FHEITKPAILAAAEDTRELDQDLVDAQEARRVLDRLYGYEVSPVLWKKVMPRLSAGRVQS 186 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDF 257 VATR+IV RER+RMAF SA YWD+ AKL+ + D P +F ARL V G+RVA GRDF Sbjct 187 VATRVIVERERERMAFVSAEYWDLTAKLNLQTAGLDGEPNSFEARLATVGGKRVAQGRDF 246 Query 258 DSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEAS 317 + G L+ E +VLD GSA ALA L G+ + V EEKPY RRPYPPFMTSTLQQEA+ Sbjct 247 NDDGQLK--SEAVVLDGGSANALATDLTGSDMQVTGVEEKPYTRRPYPPFMTSTLQQEAA 304 Query 318 RKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQ 377 RKLRF++ERTM IAQRLYENG+ITYMRTDSTTLS+S + AAR QA++LYG ++VA APRQ Sbjct 305 RKLRFTSERTMRIAQRLYENGHITYMRTDSTTLSQSGMQAARAQAKELYGAKFVANAPRQ 364 Query 378 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARG 437 Y RKVKN+QEAHEAIRPAGETF TP + +LD ++++LYELIWQRTVASQMADA+G Sbjct 365 YNRKVKNSQEAHEAIRPAGETFDTPGQLAGKLDA---EEYKLYELIWQRTVASQMADAKG 421 Query 438 MTLSLRITGMSGH---------QEVVFSATGRTLTFPGFLKAYVETVDELVGGE-ADDAE 487 M++ + + G S EV F+ATGRTLTFPGFLKAYVE G + AD+AE Sbjct 422 MSMKVTVAGSSSQAAEVPGITSTEVEFTATGRTLTFPGFLKAYVEVSSTGDGKDMADNAE 481 Query 488 RRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDR 547 +RLP ++ G L E+T +GH TNPPARY EASLVK +EELGIGRPSTY+SII+TIQDR Sbjct 482 KRLPVMSQGDALKASEVTAEGHTTNPPARYNEASLVKRMEELGIGRPSTYASIIRTIQDR 541 Query 548 GYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNF 607 GYV +G+ALVPSWVAFAV GLLEQ+FG LVDYDFT+AMEDELD IA G R NWL F Sbjct 542 GYVLPRGNALVPSWVAFAVVGLLEQNFGSLVDYDFTSAMEDELDAIAEGRTDRANWLRGF 601 Query 608 YFGGDHGVPDS----VARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNG 663 YFG D DS + R GGL+ +VG NLE IDAR VNS+ LFDD G PI VRVG+ G Sbjct 602 YFGDDSRDKDSPSSAIPRQGGLQHIVGDNLEQIDARRVNSLHLFDDAEGNPIVVRVGRYG 661 Query 664 PYLERLV-----AGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETG 718 PYLER+ A + EP QRANL +S+TPD LTL VAE+LFATPQ GR LG++PE+G Sbjct 662 PYLERVKPVPAGAPEGTEPEVQRANLPESMTPDGLTLDVAEKLFATPQGGRELGVNPESG 721 Query 719 HEIVAREGRFGPYVTEIL-------------------------------PEPAADAAAAA 747 IVAREGR+GPYVTE+L +P + A Sbjct 722 RTIVAREGRYGPYVTELLGEDEEAQAAAKAEAQWEAERDEQDREREAEGKKPLSRETKTA 781 Query 748 QGVK-KRQK---AAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQ 803 Q K KR K A KP+T SL M+ +VTLE+AL+L+SLPR VGVDP+ GE ITAQ Sbjct 782 QNQKAKRVKELVEASLKPKTASLFSDMEPASVTLEEALKLMSLPREVGVDPSDGEMITAQ 841 Query 804 NGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPAS 863 NGR+GPYLK+G+DSRSL E+QIFT+TLDEA +IYAEPKRRGR +A+ PPL++LG + S Sbjct 842 NGRFGPYLKKGSDSRSLANEEQIFTVTLDEARRIYAEPKRRGR-AAAKPPLKQLGDNDVS 900 Query 864 GKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAK 915 GKPM +K+GRFG YVTDG TNASLRKGD +ITD RA ELL++RRA+ A+ Sbjct 901 GKPMSVKEGRFGAYVTDGTTNASLRKGDTPETITDARANELLSERRAKMAAE 952 >gi|172041528|ref|YP_001801242.1| DNA topoisomerase I [Corynebacterium urealyticum DSM 7109] gi|171852832|emb|CAQ05808.1| DNA topoisomerase I [Corynebacterium urealyticum DSM 7109] Length=977 Score = 1169 bits (3024), Expect = 0.0, Method: Compositional matrix adjust. Identities = 607/951 (64%), Positives = 719/951 (76%), Gaps = 65/951 (6%) Query 18 RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDA 77 +RLVIVES TKA+K+A LGS YIVE+S GHIRDLPR A+DVPAKYK +PWARLGVNVD Sbjct 2 KRLVIVESATKAKKIAPMLGSDYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDK 61 Query 78 DFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMV 137 FE LY++SP+K+ V++LR LK VDEL LATD DREGEAIAWHLLE LKP++PV+RMV Sbjct 62 GFEALYVVSPDKKKRVADLRAKLKQVDELLLATDPDREGEAIAWHLLEVLKPKVPVRRMV 121 Query 138 FHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQS 197 FHEIT+ AI A E+ R+LD +LVDAQE+RR+LDRLYGYEVSPVLWKKV P+LSAGRVQS Sbjct 122 FHEITKSAILEAVENTRELDYNLVDAQESRRVLDRLYGYEVSPVLWKKVMPRLSAGRVQS 181 Query 198 VATRIIVARERDRMAFRSAAYWDILAKLDASVSDP----DAAPPTFSARLTAVAGRRVAT 253 VATR+IV RER+RMAFR+A YWD+ A+L DP D P +F A+L V G+R+A Sbjct 182 VATRVIVERERERMAFRAADYWDLTAEL---TIDPAARLDGDPASFQAKLATVGGQRIAQ 238 Query 254 GRDFDSLGTLR--KGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTST 311 GRDF TL+ K +VLDE A LA+G+ G +L VA+ EEKPY RRPYPPFMTST Sbjct 239 GRDFKDDATLKASKSGAPLVLDEQRAKQLASGIKGEELHVANVEEKPYTRRPYPPFMTST 298 Query 312 LQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYV 371 LQQEA RKLRF++ERTM IAQRLYENGYITYMRTDSTTLS + INAAR QA QLYG ++V Sbjct 299 LQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSTAGINAARAQAAQLYGQQFV 358 Query 372 APAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQ 431 A PRQYTRKVKN+QEAHEAIRPAGE F TP + ++LD ++F+LYELIWQRTVASQ Sbjct 359 ADGPRQYTRKVKNSQEAHEAIRPAGERFQTPGQLAQKLDA---EEFKLYELIWQRTVASQ 415 Query 432 MADARGMTLSLRITGMSGH----QEVVFSATGRTLTFPGFLKAYVETVDELVGGE-ADDA 486 MADARG ++ + I G SG EV F+ATGRT+TFPGFLKAYVE G + AD+A Sbjct 416 MADARGTSMKVTIAGTSGEPEAGTEVEFTATGRTVTFPGFLKAYVEVSRTAEGKDVADNA 475 Query 487 ERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQD 546 E+RLP +T G L ++T DGH T PPARYTEASLV+ +EELGIGRPSTY+SII+TIQD Sbjct 476 EKRLPQVTEGVFLTAEDVTADGHTTTPPARYTEASLVRKMEELGIGRPSTYASIIRTIQD 535 Query 547 RGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNN 606 RGYV +G+ALVPSWVAFAV GLLEQ+FG LVDYDFT+AMED+LD IA GNE RT WL Sbjct 536 RGYVLPRGNALVPSWVAFAVVGLLEQNFGALVDYDFTSAMEDQLDAIAEGNEDRTKWLEG 595 Query 607 FYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYL 666 FYFGG + +++ GLK +V NLE IDAR VNS+ LFDD +G PI VRVG+ GPYL Sbjct 596 FYFGG-----GTSSQNYGLKNVVAQNLESIDARRVNSLHLFDDANGVPIVVRVGRYGPYL 650 Query 667 ERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREG 726 ER+V D GE QRANL +S+TPDELTL+VAE+LFATPQ GR LG +PE G IVAREG Sbjct 651 ERMVKNDKGEEEAQRANLPESMTPDELTLEVAEKLFATPQSGRELGRNPENGRMIVAREG 710 Query 727 RFGPYVTEILPE-PAADAAAAAQGV----------KKRQKAAGP---------------- 759 RFGPYVTE+L E A+ A A+ V ++ ++ P Sbjct 711 RFGPYVTEVLGEDEEAEVTAKAEKVFLAERDEEDAERAKEGKKPLSRGTKTFENKKAKRI 770 Query 760 --------KPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYL 811 KP+T SL SM+ TVTLEDAL+L+SLPR VGVDPA GE ITAQNGRYGPYL Sbjct 771 KEILEETLKPKTASLFASMEPATVTLEDALKLMSLPREVGVDPADGEVITAQNGRYGPYL 830 Query 812 KRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKD 871 K+G DSRSL +E+++F ITLDEA +IYAEPKRRGR +A+ PPL+ LG + SGKPM +K+ Sbjct 831 KKGWDSRSLGSEEELFNITLDEARRIYAEPKRRGR-AAAKPPLKRLGDNDVSGKPMSVKE 889 Query 872 GRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRAR-------GPAK 915 GRFGPYVTDG TNASLR+GD ++TD RA ELL++RRA+ GPAK Sbjct 890 GRFGPYVTDGTTNASLRRGDTPETLTDARANELLSERRAKDAEKAAAGPAK 940 >gi|334563526|ref|ZP_08516517.1| DNA topoisomerase I subunit omega [Corynebacterium bovis DSM 20582] Length=1019 Score = 1164 bits (3011), Expect = 0.0, Method: Compositional matrix adjust. Identities = 618/951 (65%), Positives = 719/951 (76%), Gaps = 58/951 (6%) Query 11 SGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWAR 70 S G+ +RLVIVES TKARK+A YLG YIVE+S GHIRDLPR A+DVPAK+K +PWAR Sbjct 3 SNGSSGVKRLVIVESATKARKIAPYLGPDYIVEASVGHIRDLPRGAADVPAKHKKEPWAR 62 Query 71 LGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPR 130 LGVNVD DFEPLY++SP+K+ V++L+ LK VDELYLATD DREGEAIAWHLL+ LKP Sbjct 63 LGVNVDDDFEPLYVVSPDKKKKVADLKAKLKQVDELYLATDPDREGEAIAWHLLQVLKPT 122 Query 131 IPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKL 190 +PV+RMVFHEIT+PAI AAAE+ R+LD DLVDAQETRR+LDRLYGYEVSPVLWKKV P+L Sbjct 123 VPVRRMVFHEITKPAILAAAENTRELDHDLVDAQETRRVLDRLYGYEVSPVLWKKVMPRL 182 Query 191 SAGRVQSVATRIIVARERDRMAFRSAAYWDILAKL----DASVSDPDAAPPTFSARLTAV 246 SAGRVQSVATR+IV RER+RMAF +A YWD+ A L A VS P A+L + Sbjct 183 SAGRVQSVATRVIVERERERMAFIAADYWDLTAHLRLLDGAGVS--GEGPREVDAKLARI 240 Query 247 AGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPP 306 G RVA GRDF G +R D V VLD+ +ATALA GL G ++ V++ EEKPY RRPYPP Sbjct 241 DGTRVAQGRDFTDRGEVRTKD-VRVLDKTAATALADGLRGREMRVSAVEEKPYTRRPYPP 299 Query 307 FMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLY 366 FMTSTLQQEA RKL F++ERTM IAQRLYENG+ITYMRTDSTTLS S INAAR QA +LY Sbjct 300 FMTSTLQQEAGRKLHFTSERTMRIAQRLYENGHITYMRTDSTTLSTSGINAARAQAAELY 359 Query 367 GDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQR 426 G+ +VA APRQYTRKVKN+QEAHEAIRPAGETFATP + LD ++F+LYELIWQR Sbjct 360 GERFVADAPRQYTRKVKNSQEAHEAIRPAGETFATPGQLSGRLDA---EEFKLYELIWQR 416 Query 427 TVASQMADARGMTLSLRITGMSGHQEVV-FSATGRTLTFPGFLKAYVETVDELVGGE-AD 484 TVASQMADARG ++ + +TG +G E F+A+GRT+TFPGFLKAYVET + G + AD Sbjct 417 TVASQMADARGTSVKVTVTGQAGSGETCDFTASGRTITFPGFLKAYVETTRQADGRDVAD 476 Query 485 DAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTI 544 +AER LP L G L E++ DGH T PPARYTEASLVK +EELGIGRPSTY+SIIKTI Sbjct 477 NAERHLPVLAEGDGLSAEEISADGHTTTPPARYTEASLVKKMEELGIGRPSTYASIIKTI 536 Query 545 QDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWL 604 QDRGYV +G+ALVPSWVAFAV GLLE +FG LVDYDFT++MEDELD+IAAG E R++WL Sbjct 537 QDRGYVLPRGNALVPSWVAFAVVGLLEDNFGSLVDYDFTSSMEDELDDIAAGRENRSDWL 596 Query 605 NNFYFGGDHGVPD----SVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVG 660 FYF GD G D +VAR GGLK LVG NLE IDAR VNS+ LFDD G PIYVRVG Sbjct 597 RGFYF-GDAGASDATAETVARLGGLKALVGNNLEQIDARRVNSLHLFDDADGTPIYVRVG 655 Query 661 KNGPYLERLV-----AGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDP 715 + G YLER A + EP QRANL +S+TPDEL L+ AE+LFATPQ GR LG +P Sbjct 656 RYGAYLERTKPVPAGAPEGTEPEVQRANLPESMTPDELDLETAEKLFATPQGGRELGRNP 715 Query 716 ETGHEIVAREGRFGPYVTEILPEP------------------AADAAAAAQGVK------ 751 G IV +EGRFGPYVTE + E A DA A +G K Sbjct 716 ANGRMIVVKEGRFGPYVTERVTEDEEAGATAEAERTVDAEWDADDAERAKEGKKPFNRTT 775 Query 752 -----KRQKAAGP------KPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEI 800 KR+K KP T SL SMD TV L+DAL+LLSLPR VGVDP+ GE I Sbjct 776 KTAAAKREKRVRQLVDETLKPATASLFSSMDTGTVGLDDALKLLSLPREVGVDPSDGEVI 835 Query 801 TAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTD 860 TAQNGRYGPYLK+GNDSRSL E+ IFT+TLDEA +IYAEPKRRGRQ+A PPL++LG + Sbjct 836 TAQNGRYGPYLKKGNDSRSLAKEEDIFTVTLDEARRIYAEPKRRGRQAAQ-PPLKQLGDN 894 Query 861 PASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRAR 911 SGKPM +KDGRFGPYVTDG+TNASLR+GD+ +ITD RA ELL++RRA+ Sbjct 895 DVSGKPMTVKDGRFGPYVTDGQTNASLRRGDNPETITDARANELLSERRAK 945 >gi|213966048|ref|ZP_03394237.1| putative DNA topoisomerase I [Corynebacterium amycolatum SK46] gi|213951343|gb|EEB62736.1| putative DNA topoisomerase I [Corynebacterium amycolatum SK46] Length=1036 Score = 1161 bits (3004), Expect = 0.0, Method: Compositional matrix adjust. Identities = 601/967 (63%), Positives = 722/967 (75%), Gaps = 54/967 (5%) Query 1 LADPKTKGRGSGGNGSG-RRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDV 59 L D KT S N G +RLVIVES TKARK+ YLG YIVE+S GHIRDLPR A+DV Sbjct 40 LQDRKT----SMANSDGLKRLVIVESATKARKIQPYLGDDYIVEASVGHIRDLPRGAADV 95 Query 60 PAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAI 119 PA+YK +PWARLGVNVD F PLY++S +K+ V++L+ LK+VDELYLATD DREGEAI Sbjct 96 PARYKKEPWARLGVNVDNGFAPLYVVSADKKKKVADLKAKLKEVDELYLATDPDREGEAI 155 Query 120 AWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVS 179 AWHLLE LKP++PV+RMVFHEIT+ AI AA + R+LD +LVDAQE RRILDRLYGYEVS Sbjct 156 AWHLLEVLKPKVPVRRMVFHEITKQAILEAAANTRELDQNLVDAQEGRRILDRLYGYEVS 215 Query 180 PVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDA-APPT 238 PVLWKKV P+LSAGRVQSVATR+IV RER+RMAF SA YWD+ A LD + DA P Sbjct 216 PVLWKKVMPRLSAGRVQSVATRVIVERERERMAFISAEYWDVAATLDTGSASADANQPKD 275 Query 239 FSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKP 298 F A LT+V G+RVA GRDFD G L+K D + V+D+ A LAA L G++L VAS EEKP Sbjct 276 FVATLTSVDGQRVAQGRDFDDRGQLKKSDGIRVVDKQLAETLAADLVGSELKVASVEEKP 335 Query 299 YARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAA 358 Y RRPYPPFMTSTLQQEA RKL +++ERTM +AQRLYENG+ITYMRTDSTTLS++ I+AA Sbjct 336 YTRRPYPPFMTSTLQQEAGRKLHYTSERTMRVAQRLYENGHITYMRTDSTTLSKAGIDAA 395 Query 359 RTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFR 418 R QA +LYG EYVA APRQY+RKVKN+QEAHEAIRPAGETFATP + LD ++F+ Sbjct 396 RKQALELYGSEYVADAPRQYSRKVKNSQEAHEAIRPAGETFATPGQLAGSLDA---EEFK 452 Query 419 LYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDEL 478 LYELIWQRTVASQMADARG ++ + I G + V F++TGRT+ FPGFLKAYVE V L Sbjct 453 LYELIWQRTVASQMADARGTSMKVTIAGATDTHAVEFASTGRTIRFPGFLKAYVE-VSAL 511 Query 479 VGGE--ADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPST 536 G AD+AE+RLP LT GQ L + + D H+TNPPAR+TEASLVK +E+LGIGRPST Sbjct 512 SDGRKVADNAEKRLPQLTEGQGLTATDFSADSHSTNPPARFTEASLVKKMEDLGIGRPST 571 Query 537 YSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAG 596 Y+SIIKTIQDRGYV+ +G+ALVPSWVAFAV GL+E+ F LV+YDFT+ +EDELD IAAG Sbjct 572 YASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLMEEAFSDLVNYDFTSELEDELDGIAAG 631 Query 597 NERRTNWLNNFYFGGD----HGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHG 652 N+ RT WL FYFG + H D++A GGLK ++ +NLE IDAR+VNS+ LFDD G Sbjct 632 NKDRTTWLTGFYFGDEKDHRHKGADAIATHGGLKNIIDVNLESIDARKVNSLHLFDDAEG 691 Query 653 RPIYVRVGKNGPYLERLV--AGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRT 710 PI VRVG+ GPYLER AG+ G QRAN+ +++TPDEL L AE+L A PQ GR Sbjct 692 NPIIVRVGRYGPYLERTRPGAGENGADEVQRANIPEAMTPDELDLAAAEKLLAMPQGGRE 751 Query 711 LGLDPETGHEIVAREGRFGPYVTEILPE------------------PAADAAAAAQGVKK 752 LG++P G IVAR+GR+GPYVTE++ + DA AA+G +K Sbjct 752 LGINPANGRMIVARDGRYGPYVTELVTDEEREGVVAKAEEIIAAERAEEDAQRAAEGKRK 811 Query 753 RQ---KAAGP--------------KPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPA 795 + K A KP+T SL SM+ TVTLE+AL+L+SLPR VGVDP Sbjct 812 KNWETKTAAKQKEKRTAEIIEETLKPKTASLFSSMEPSTVTLEEALKLMSLPREVGVDPV 871 Query 796 SGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLR 855 E ITAQNGRYGPYLK+G DSRSL E+QIFT+TLDEA +IYAEPKRRGR +A+ PPL+ Sbjct 872 DNEVITAQNGRYGPYLKKGTDSRSLANEEQIFTVTLDEARRIYAEPKRRGR-AAAKPPLK 930 Query 856 ELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAK 915 +LG + SG+PM +KDGRFGPYVTDG TNASLRKGD ++TD RA ELL++RRA+ A Sbjct 931 QLGDNDVSGRPMSVKDGRFGPYVTDGVTNASLRKGDTPETLTDARACELLSERRAKEAAN 990 Query 916 RPARKAA 922 +KAA Sbjct 991 GGTKKAA 997 Lambda K H 0.315 0.133 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 2316268889710 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40