BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3677c Length=264 Score E Sequences producing significant alignments: (Bits) Value gi|15610813|ref|NP_218194.1| hydrolase [Mycobacterium tuberculos... 515 3e-144 gi|240172238|ref|ZP_04750897.1| hypothetical protein MkanA1_2318... 427 9e-118 gi|15828235|ref|NP_302498.1| hydrolase [Mycobacterium leprae TN]... 419 3e-115 gi|296166734|ref|ZP_06849158.1| metallo-beta-lactamase superfami... 417 6e-115 gi|118619418|ref|YP_907750.1| hypothetical protein MUL_4251 [Myc... 417 1e-114 gi|183985135|ref|YP_001853426.1| hypothetical protein MMAR_5165 ... 416 1e-114 gi|254820835|ref|ZP_05225836.1| metallo-beta-lactamase family pr... 414 9e-114 gi|108801782|ref|YP_641979.1| beta-lactamase-like protein [Mycob... 393 1e-107 gi|126437770|ref|YP_001073461.1| beta-lactamase domain-containin... 393 2e-107 gi|254773457|ref|ZP_05214973.1| metallo-beta-lactamase family pr... 392 2e-107 gi|118466139|ref|YP_879734.1| metallo-beta-lactamase [Mycobacter... 389 2e-106 gi|342861986|ref|ZP_08718630.1| metallo-beta-lactamase [Mycobact... 389 3e-106 gi|41406495|ref|NP_959331.1| hypothetical protein MAP0397 [Mycob... 383 2e-104 gi|333992595|ref|YP_004525209.1| hydrolase [Mycobacterium sp. JD... 377 8e-103 gi|145221962|ref|YP_001132640.1| beta-lactamase domain-containin... 375 4e-102 gi|315446302|ref|YP_004079181.1| Zn-dependent hydrolase, glyoxyl... 374 7e-102 gi|118473784|ref|YP_890410.1| metallo-beta-lactamase [Mycobacter... 373 1e-101 gi|120406383|ref|YP_956212.1| beta-lactamase domain-containing p... 365 3e-99 gi|336460827|gb|EGO39712.1| Zn-dependent hydrolase, glyoxylase [... 363 1e-98 gi|169627518|ref|YP_001701167.1| beta-lactamase-like hydrolase [... 359 2e-97 gi|229492190|ref|ZP_04385999.1| beta-lactamase domain protein [R... 301 5e-80 gi|226303958|ref|YP_002763916.1| beta-lactamase [Rhodococcus ery... 301 9e-80 gi|226363640|ref|YP_002781422.1| beta-lactamase [Rhodococcus opa... 297 1e-78 gi|111021296|ref|YP_704268.1| hydrolase [Rhodococcus jostii RHA1... 296 1e-78 gi|54022309|ref|YP_116551.1| putative hydrolase [Nocardia farcin... 295 6e-78 gi|333917942|ref|YP_004491523.1| hydrolase [Amycolicicoccus subf... 285 5e-75 gi|312137976|ref|YP_004005312.1| metallo-beta-lactamase superfam... 283 2e-74 gi|256374403|ref|YP_003098063.1| beta-lactamase domain-containin... 280 2e-73 gi|134096939|ref|YP_001102600.1| metallo-beta-lactamase superfam... 263 2e-68 gi|296141601|ref|YP_003648844.1| beta-lactamase [Tsukamurella pa... 262 4e-68 gi|343926472|ref|ZP_08765977.1| putative beta-lactamase [Gordoni... 260 1e-67 gi|324999015|ref|ZP_08120127.1| beta-lactamase domain protein [P... 258 7e-67 gi|262200519|ref|YP_003271727.1| beta-lactamase [Gordonia bronch... 254 7e-66 gi|288918351|ref|ZP_06412704.1| beta-lactamase domain protein [F... 251 8e-65 gi|300790645|ref|YP_003770936.1| beta-lactamase class B [Amycola... 248 6e-64 gi|331700208|ref|YP_004336447.1| beta-lactamase domain-containin... 247 1e-63 gi|220913010|ref|YP_002488319.1| beta-lactamase [Arthrobacter ch... 247 1e-63 gi|312194234|ref|YP_004014295.1| beta-lactamase domain protein [... 246 3e-63 gi|302530876|ref|ZP_07283218.1| beta-lactamase domain-containing... 241 6e-62 gi|158312194|ref|YP_001504702.1| beta-lactamase domain-containin... 236 2e-60 gi|257057565|ref|YP_003135397.1| Zn-dependent hydrolase, glyoxyl... 234 1e-59 gi|317506664|ref|ZP_07964454.1| metallo-beta-lactamase superfami... 234 1e-59 gi|111225889|ref|YP_716683.1| putative hydrolase [Frankia alni A... 234 1e-59 gi|336180121|ref|YP_004585496.1| putative hydrolase [Frankia sym... 231 1e-58 gi|325963755|ref|YP_004241661.1| Zn-dependent hydrolase, glyoxyl... 230 1e-58 gi|296393531|ref|YP_003658415.1| beta-lactamase [Segniliparus ro... 230 1e-58 gi|326383489|ref|ZP_08205176.1| beta-lactamase domain-containing... 230 2e-58 gi|184199938|ref|YP_001854145.1| hypothetical protein KRH_02920 ... 228 6e-58 gi|116671074|ref|YP_832007.1| beta-lactamase domain-containing p... 228 8e-58 gi|258650963|ref|YP_003200119.1| beta-lactamase domain-containin... 227 1e-57 >gi|15610813|ref|NP_218194.1| hydrolase [Mycobacterium tuberculosis H37Rv] gi|15843294|ref|NP_338331.1| metallo-beta-lactamase superfamily protein [Mycobacterium tuberculosis CDC1551] gi|31794847|ref|NP_857340.1| putative hydrolase [Mycobacterium bovis AF2122/97] 80 more sequence titles Length=264 Score = 515 bits (1326), Expect = 3e-144, Method: Compositional matrix adjust. Identities = 264/264 (100%), Positives = 264/264 (100%), Gaps = 0/264 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD Sbjct 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE Sbjct 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR Sbjct 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL Sbjct 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 Query 241 DVDEKLWNAAEWSVQAQLDYLRTR 264 DVDEKLWNAAEWSVQAQLDYLRTR Sbjct 241 DVDEKLWNAAEWSVQAQLDYLRTR 264 >gi|240172238|ref|ZP_04750897.1| hypothetical protein MkanA1_23184 [Mycobacterium kansasii ATCC 12478] Length=261 Score = 427 bits (1097), Expect = 9e-118, Method: Compositional matrix adjust. Identities = 212/257 (83%), Positives = 237/257 (93%), Gaps = 0/257 (0%) Query 6 ESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHL 65 ESLTHPAYG+LR VTDTASVL+ADNPGL+TL+GTNTWVL GP SDELV+VDPGP DDEH+ Sbjct 3 ESLTHPAYGRLRPVTDTASVLVADNPGLMTLEGTNTWVLCGPGSDELVIVDPGPGDDEHI 62 Query 66 ARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVA 125 AR+AALGR+ALVLISHRHGDHT GIDKLV LTGAPVRAA+PQF R DG TL+DGEVI+ A Sbjct 63 ARIAALGRVALVLISHRHGDHTDGIDKLVELTGAPVRAANPQFQRGDGVTLSDGEVIEAA 122 Query 126 GLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLG 185 GL ITVLATPGHTADSLSF+L+DAVLTAD+VLG GTTV+DK+DGSL DYLESLHRLRGLG Sbjct 123 GLAITVLATPGHTADSLSFLLEDAVLTADSVLGRGTTVLDKDDGSLTDYLESLHRLRGLG 182 Query 186 RRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEK 245 +RTVLPGHGP+L D+ A+A GYL HR ERLEQ+R ALR+LGDDAT R+VVEHVY+DVDEK Sbjct 183 QRTVLPGHGPELTDVAAVAQGYLAHRKERLEQVRCALRELGDDATTRQVVEHVYVDVDEK 242 Query 246 LWNAAEWSVQAQLDYLR 262 LW+AAEWSVQAQLDYLR Sbjct 243 LWDAAEWSVQAQLDYLR 259 >gi|15828235|ref|NP_302498.1| hydrolase [Mycobacterium leprae TN] gi|221230712|ref|YP_002504128.1| putative hydrolase [Mycobacterium leprae Br4923] gi|13093928|emb|CAC31819.1| putative hydrolase [Mycobacterium leprae] gi|219933819|emb|CAR72401.1| putative hydrolase [Mycobacterium leprae Br4923] Length=262 Score = 419 bits (1076), Expect = 3e-115, Method: Compositional matrix adjust. Identities = 215/262 (83%), Positives = 235/262 (90%), Gaps = 1/262 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 M++ + L HPAYG+LRAVTDTASVLLADNPGLLTL+GTNTWVLRGP S ELV+VDPGP Sbjct 1 MAEVVKWLAHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGPGSGELVIVDPGPG 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 D EH+ +VA LGRIALVLISHRH DHT GIDKLV LTGAPV AADPQFLR DG TLTD E Sbjct 61 D-EHIVQVATLGRIALVLISHRHPDHTDGIDKLVELTGAPVCAADPQFLRGDGVTLTDRE 119 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID GLTITVLATPGHTADS+SFVL DAVLTAD+VLG GTTVID +DGSLADYLESLHR Sbjct 120 VIDAGGLTITVLATPGHTADSMSFVLADAVLTADSVLGHGTTVIDPDDGSLADYLESLHR 179 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 L GLGRRTVLPGHGPDL +LE++ASGYL+HR ERLEQ+RAALR+LGDDAT R+VVEHVY+ Sbjct 180 LSGLGRRTVLPGHGPDLANLESVASGYLVHRQERLEQVRAALRELGDDATARQVVEHVYV 239 Query 241 DVDEKLWNAAEWSVQAQLDYLR 262 DVDEK W+AAEWSVQAQLDYLR Sbjct 240 DVDEKFWDAAEWSVQAQLDYLR 261 >gi|296166734|ref|ZP_06849158.1| metallo-beta-lactamase superfamily protein [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295897904|gb|EFG77486.1| metallo-beta-lactamase superfamily protein [Mycobacterium parascrofulaceum ATCC BAA-614] Length=264 Score = 417 bits (1073), Expect = 6e-115, Method: Compositional matrix adjust. Identities = 214/262 (82%), Positives = 234/262 (90%), Gaps = 0/262 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 M++ ES +HPAYG+LRAVTDTASVLLADNPGLLTL+GTNTWVLRG SDELVVVDPGPD Sbjct 1 MTEAPESPSHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVVVDPGPD 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 D EH+ARVA LGR+ LVLISHRHGDHT GIDKLV TGA VR+A FLR G LTDGE Sbjct 61 DAEHIARVAGLGRVTLVLISHRHGDHTDGIDKLVERTGATVRSAGSGFLRGLGGHLTDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID AGL I V+ATPGHTADSLSFVL+DAVLTAD+VLG GTTVIDKEDGSLA YLESL R Sbjct 121 VIDAAGLKIKVMATPGHTADSLSFVLEDAVLTADSVLGRGTTVIDKEDGSLAAYLESLRR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLG RTVLPGHGPDL +L+A+ASGYL+HRHERLEQ+RAALRD+GDDAT R+VVEHVYL Sbjct 181 LRGLGARTVLPGHGPDLPNLQAVASGYLMHRHERLEQVRAALRDIGDDATARQVVEHVYL 240 Query 241 DVDEKLWNAAEWSVQAQLDYLR 262 DVDEKLW+AAEWSVQAQLDYL+ Sbjct 241 DVDEKLWDAAEWSVQAQLDYLQ 262 >gi|118619418|ref|YP_907750.1| hypothetical protein MUL_4251 [Mycobacterium ulcerans Agy99] gi|118571528|gb|ABL06279.1| conserved hypothetical Zn-dependent hydrolase [Mycobacterium ulcerans Agy99] Length=268 Score = 417 bits (1071), Expect = 1e-114, Method: Compositional matrix adjust. Identities = 207/261 (80%), Positives = 233/261 (90%), Gaps = 0/261 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 MS+TA SLTHPAYG+LR VTD ASVL+ADNPGLLTL+GTNTWVLRGP SDELVVVDPGP Sbjct 1 MSETAGSLTHPAYGRLRPVTDLASVLVADNPGLLTLEGTNTWVLRGPRSDELVVVDPGPA 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEH+AR+AALGRIALVLISHRHGDHT GIDKL TGAPVRAADPQFLR D L+DGE Sbjct 61 DDEHIARIAALGRIALVLISHRHGDHTDGIDKLFERTGAPVRAADPQFLRGDPVALSDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID GL ITVLATPGHTADSLSFVL+DAVLTAD+VLG GTTV+DK+DGSL++YLESLHR Sbjct 121 VIDAGGLKITVLATPGHTADSLSFVLEDAVLTADSVLGRGTTVLDKQDGSLSEYLESLHR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLG R VLPGHGPDL D+ +A GYL HR ERLEQ+R+ALR+LG+ A+ R++VEHVY+ Sbjct 181 LRGLGPRMVLPGHGPDLADIRIVAQGYLAHRQERLEQVRSALRELGEQASARQIVEHVYV 240 Query 241 DVDEKLWNAAEWSVQAQLDYL 261 DVDEKLW+AAEWSVQ QL++L Sbjct 241 DVDEKLWDAAEWSVQVQLNHL 261 >gi|183985135|ref|YP_001853426.1| hypothetical protein MMAR_5165 [Mycobacterium marinum M] gi|183178461|gb|ACC43571.1| conserved hypothetical Zn-dependent hydrolase [Mycobacterium marinum M] Length=268 Score = 416 bits (1070), Expect = 1e-114, Method: Compositional matrix adjust. Identities = 207/261 (80%), Positives = 233/261 (90%), Gaps = 0/261 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 MS+TA SLTHPAYG+LR VTD ASVL+ADNPGLLTL+GTNTWVLRGP SDELVVVDPGP Sbjct 1 MSETAGSLTHPAYGRLRPVTDLASVLVADNPGLLTLEGTNTWVLRGPRSDELVVVDPGPA 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEH+AR+AALGRIALVLISHRHGDHT GIDKL TGAPVRAADPQFLR D L+DGE Sbjct 61 DDEHIARIAALGRIALVLISHRHGDHTDGIDKLFERTGAPVRAADPQFLRGDPVALSDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID GL ITVLATPGHTADSLSFVL+DAVLTAD+VLG GTTV+DK+DGSL++YLESLHR Sbjct 121 VIDAGGLKITVLATPGHTADSLSFVLEDAVLTADSVLGRGTTVLDKQDGSLSEYLESLHR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLG R VLPGHGPDL D+ +A GYL HR ERLEQ+R+ALR+LG+ A+ R++VEHVY+ Sbjct 181 LRGLGPRMVLPGHGPDLADIRIVAQGYLAHRQERLEQVRSALRELGEQASARQIVEHVYV 240 Query 241 DVDEKLWNAAEWSVQAQLDYL 261 DVDEKLW+AAEWSVQ QL++L Sbjct 241 DVDEKLWDAAEWSVQVQLNHL 261 >gi|254820835|ref|ZP_05225836.1| metallo-beta-lactamase family protein [Mycobacterium intracellulare ATCC 13950] Length=263 Score = 414 bits (1063), Expect = 9e-114, Method: Compositional matrix adjust. Identities = 207/262 (80%), Positives = 231/262 (89%), Gaps = 0/262 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 M++ AE THPAYG+LRAVTDT SVLLADNPGL+TL+GTNTWVLRGP SDELV+VDPGPD Sbjct 1 MTEVAEPPTHPAYGRLRAVTDTVSVLLADNPGLMTLEGTNTWVLRGPRSDELVIVDPGPD 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEH+ARVAALGRI LVLISHRHGDHT GIDKLV TGA VR+A FLR G L DGE Sbjct 61 DDEHIARVAALGRIGLVLISHRHGDHTDGIDKLVERTGATVRSAGSGFLRGLGGELVDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID AGL I V+ATPGHTADSLSFVLDDAVLTADT+LG GTTV+D EDGSL DYLESLHR Sbjct 121 VIDAAGLRIKVMATPGHTADSLSFVLDDAVLTADTILGRGTTVMDSEDGSLTDYLESLHR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLGRR VLPGHGP+L DLEA+A GY+ HRHERLEQ+R+ALR+LG+DA R++VEHVY+ Sbjct 181 LRGLGRRAVLPGHGPELSDLEAVARGYIAHRHERLEQVRSALRELGEDAGARQIVEHVYV 240 Query 241 DVDEKLWNAAEWSVQAQLDYLR 262 DVDEKLW+AAEWSVQ QL++LR Sbjct 241 DVDEKLWDAAEWSVQVQLNHLR 262 >gi|108801782|ref|YP_641979.1| beta-lactamase-like protein [Mycobacterium sp. MCS] gi|119870933|ref|YP_940885.1| beta-lactamase domain-containing protein [Mycobacterium sp. KMS] gi|108772201|gb|ABG10923.1| beta-lactamase-like protein [Mycobacterium sp. MCS] gi|119697022|gb|ABL94095.1| beta-lactamase domain protein [Mycobacterium sp. KMS] Length=259 Score = 393 bits (1010), Expect = 1e-107, Method: Compositional matrix adjust. Identities = 203/254 (80%), Positives = 221/254 (88%), Gaps = 0/254 (0%) Query 10 HPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVA 69 HPAYG LR VT+TASVLL +NPGL+TLDGTNTWVLR P SDELV+VDPGPDDDEH+A+VA Sbjct 6 HPAYGLLRPVTETASVLLCNNPGLMTLDGTNTWVLRAPGSDELVIVDPGPDDDEHIAKVA 65 Query 70 ALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTI 129 LGRIALVLISH+H DHT GIDK+V TGA VR+ FLR G LTDGEVID AGL I Sbjct 66 ELGRIALVLISHKHEDHTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIDAAGLRI 125 Query 130 TVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTV 189 V+ATPGHTADSLSFVLDDAVLTADTVLG GTTVID EDGSL DYLESLHRL+GLGRRTV Sbjct 126 VVMATPGHTADSLSFVLDDAVLTADTVLGRGTTVIDTEDGSLRDYLESLHRLQGLGRRTV 185 Query 190 LPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKLWNA 249 LPGHGPDL DLEA+ + YL HR ERLEQ+RAALR+LGDDAT R+VVEHVY DVDEKLW+A Sbjct 186 LPGHGPDLPDLEAVTAMYLTHREERLEQVRAALRELGDDATARQVVEHVYTDVDEKLWDA 245 Query 250 AEWSVQAQLDYLRT 263 AE SV+AQLDYLRT Sbjct 246 AEKSVEAQLDYLRT 259 >gi|126437770|ref|YP_001073461.1| beta-lactamase domain-containing protein [Mycobacterium sp. JLS] gi|126237570|gb|ABO00971.1| beta-lactamase domain protein [Mycobacterium sp. JLS] Length=259 Score = 393 bits (1009), Expect = 2e-107, Method: Compositional matrix adjust. Identities = 203/254 (80%), Positives = 222/254 (88%), Gaps = 0/254 (0%) Query 10 HPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVA 69 HPAYG LR VT+TASVLL +NPGL+TLDGTNTWVLR P SDELV+VDPGPDDDEH+A+VA Sbjct 6 HPAYGLLRPVTETASVLLCNNPGLMTLDGTNTWVLRAPGSDELVIVDPGPDDDEHIAKVA 65 Query 70 ALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTI 129 LGRIALVLISH+H DHT GIDK+V TGA VR+ FLR G LTDGEVID AGL I Sbjct 66 ELGRIALVLISHKHEDHTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIDAAGLRI 125 Query 130 TVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTV 189 TV+ATPGHTADSLSFVLDDAVLTADTVLG GTTVID EDGSL DYLESLHRL+GLGRRTV Sbjct 126 TVMATPGHTADSLSFVLDDAVLTADTVLGRGTTVIDTEDGSLRDYLESLHRLQGLGRRTV 185 Query 190 LPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKLWNA 249 LPGHGPDL DLEA+ + YL HR ERL+Q+RAALR+LGDDAT R+VVEHVY DVDEKLW+A Sbjct 186 LPGHGPDLPDLEAVTAMYLTHREERLDQVRAALRELGDDATARQVVEHVYTDVDEKLWDA 245 Query 250 AEWSVQAQLDYLRT 263 AE SV+AQLDYLRT Sbjct 246 AEKSVEAQLDYLRT 259 >gi|254773457|ref|ZP_05214973.1| metallo-beta-lactamase family protein [Mycobacterium avium subsp. avium ATCC 25291] Length=267 Score = 392 bits (1008), Expect = 2e-107, Method: Compositional matrix adjust. Identities = 208/263 (80%), Positives = 234/263 (89%), Gaps = 0/263 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 M++ AES THPAYG+LRAVTDTASVLLADNPGLLTL+GTNTWVLRGP SDELV+VDPGPD Sbjct 1 MTEVAESPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGPGSDELVIVDPGPD 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEH+AR+AALGRIALVLISHRHGDHT GIDKLV TGA VR+A FLR G LTDGE Sbjct 61 DDEHIARIAALGRIALVLISHRHGDHTDGIDKLVERTGATVRSAGSGFLRGLGGELTDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID AGL I V+ATPGHTADSL F+LDDAVLTADTVLG GTTV+DKEDGSL DYLESL R Sbjct 121 VIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRGTTVLDKEDGSLTDYLESLRR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLGRR VLPGHGPDL+DLE++A GYL HR ERL+Q+R+A+R+LG+D + R +VEHVY+ Sbjct 181 LRGLGRRAVLPGHGPDLIDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV 240 Query 241 DVDEKLWNAAEWSVQAQLDYLRT 263 DVDEKLW+AAEWSVQ QL+YLR+ Sbjct 241 DVDEKLWDAAEWSVQVQLNYLRS 263 >gi|118466139|ref|YP_879734.1| metallo-beta-lactamase [Mycobacterium avium 104] gi|118167426|gb|ABK68323.1| metallo-beta-lactamase family protein [Mycobacterium avium 104] Length=267 Score = 389 bits (999), Expect = 2e-106, Method: Compositional matrix adjust. Identities = 207/263 (79%), Positives = 233/263 (89%), Gaps = 0/263 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 M++ AES THPAYG+LRAVTDTASVLLADNPGLLTL+GTNTWVLRGP SDELV+VDPGPD Sbjct 1 MTEVAESPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGPGSDELVIVDPGPD 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEH+AR+AALGRIALVLISHRHGDHT GIDKLV TGA VR+A FLR G LTDGE Sbjct 61 DDEHIARIAALGRIALVLISHRHGDHTDGIDKLVERTGATVRSAGSGFLRGLGGELTDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID AGL I V+ATPGHTADSL F+LDDAVLTADTVLG GTTV+DKEDGSL DYLESL R Sbjct 121 VIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRGTTVLDKEDGSLTDYLESLRR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLGRR VLPGHGPDL DLE++A GYL HR ERL+Q+R+A+R+LG+D + R +VEHVY+ Sbjct 181 LRGLGRRAVLPGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV 240 Query 241 DVDEKLWNAAEWSVQAQLDYLRT 263 DVDEKLW+AAEWSVQ QL++LR+ Sbjct 241 DVDEKLWDAAEWSVQVQLNHLRS 263 >gi|342861986|ref|ZP_08718630.1| metallo-beta-lactamase [Mycobacterium colombiense CECT 3035] gi|342130526|gb|EGT83835.1| metallo-beta-lactamase [Mycobacterium colombiense CECT 3035] Length=264 Score = 389 bits (998), Expect = 3e-106, Method: Compositional matrix adjust. Identities = 209/262 (80%), Positives = 229/262 (88%), Gaps = 0/262 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 M++ AESLTHPAY LR VTDTASVLLADNPGLLTL+GTNTWVLRGP SDELV+VDPGPD Sbjct 1 MTQAAESLTHPAYATLRPVTDTASVLLADNPGLLTLEGTNTWVLRGPRSDELVIVDPGPD 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEH+AR+AALGR+ALVLISHRH DHT GIDKLV LTGA VR+A FLR G LTDGE Sbjct 61 DDEHIARLAALGRVALVLISHRHSDHTDGIDKLVELTGATVRSAGSGFLRGLGGELTDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID AGL I V+ATPGHTADSLSF+LDDAVLTADT+LG GT V+DKEDGSL DYLESL R Sbjct 121 VIDAAGLEIKVMATPGHTADSLSFLLDDAVLTADTILGRGTAVLDKEDGSLTDYLESLRR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLGRRTVLPGHGPDL DLE +A GYL HR ERL+Q+R+ALR+LG+D R VVEHVY+ Sbjct 181 LRGLGRRTVLPGHGPDLTDLERVAHGYLEHRRERLDQVRSALRELGEDVGARRVVEHVYV 240 Query 241 DVDEKLWNAAEWSVQAQLDYLR 262 DVDEKLW+AAEWSVQ QLDYLR Sbjct 241 DVDEKLWDAAEWSVQVQLDYLR 262 >gi|41406495|ref|NP_959331.1| hypothetical protein MAP0397 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41394844|gb|AAS02714.1| hypothetical protein MAP_0397 [Mycobacterium avium subsp. paratuberculosis K-10] Length=267 Score = 383 bits (983), Expect = 2e-104, Method: Compositional matrix adjust. Identities = 205/263 (78%), Positives = 231/263 (88%), Gaps = 0/263 (0%) Query 1 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD 60 M++ A S THPAYG+LRAVTDTASVLLADNPGLLTL+GTNTWVLRG SDELV+VDPGPD Sbjct 1 MTEVAASPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVIVDPGPD 60 Query 61 DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE 120 DDEH+AR+AALGRIALVLISHRHGDHT GIDKLV TGA VR+A FLR G LTDGE Sbjct 61 DDEHIARIAALGRIALVLISHRHGDHTDGIDKLVGRTGAIVRSAGSGFLRGLGGELTDGE 120 Query 121 VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR 180 VID AGL I V+ATPGHTADSL F+LDDAVLTADTVLG GTTV+DKEDGSL DYLESL R Sbjct 121 VIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRGTTVLDKEDGSLTDYLESLRR 180 Query 181 LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 LRGLGRR VLPGHGPDL DLE++A GYL HR ERL+Q+R+A+R+LG+D + R +VEHVY+ Sbjct 181 LRGLGRRAVLPGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV 240 Query 241 DVDEKLWNAAEWSVQAQLDYLRT 263 DVDEKLW+AAEWSVQ QL++LR+ Sbjct 241 DVDEKLWDAAEWSVQVQLNHLRS 263 >gi|333992595|ref|YP_004525209.1| hydrolase [Mycobacterium sp. JDM601] gi|333488563|gb|AEF37955.1| hydrolase [Mycobacterium sp. JDM601] Length=259 Score = 377 bits (968), Expect = 8e-103, Method: Compositional matrix adjust. Identities = 190/256 (75%), Positives = 221/256 (87%), Gaps = 0/256 (0%) Query 7 SLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA 66 SL+HPAYG+LR VT+TASVLLADNPGL+TL+GTNTWVLRGP SDE+V+VDPGPDDDEH+ Sbjct 2 SLSHPAYGRLRPVTETASVLLADNPGLMTLEGTNTWVLRGPRSDEVVIVDPGPDDDEHIG 61 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 R+A LG++ALVLISHRH DHT GIDKL PV +A F RR G L DG+VI+ A Sbjct 62 RLAELGKVALVLISHRHFDHTDGIDKLADSLDVPVYSAGSGFQRRLGGGLIDGQVIEAAD 121 Query 127 LTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGR 186 L ITVLATPGHTADSLSFVLDDAVLTADTVLG GTTVID EDG LA YL+SLHRLRGLG+ Sbjct 122 LRITVLATPGHTADSLSFVLDDAVLTADTVLGRGTTVIDTEDGDLAHYLDSLHRLRGLGQ 181 Query 187 RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKL 246 RTVLPGHGP+L +++A+ +GYL HR +RL+Q+R+AL +LG+DAT R+VVEHVY DVDE+L Sbjct 182 RTVLPGHGPELPNIDAVTAGYLAHREQRLDQVRSALAELGEDATTRQVVEHVYTDVDEEL 241 Query 247 WNAAEWSVQAQLDYLR 262 W+AAEWSVQAQLDYLR Sbjct 242 WDAAEWSVQAQLDYLR 257 >gi|145221962|ref|YP_001132640.1| beta-lactamase domain-containing protein [Mycobacterium gilvum PYR-GCK] gi|145214448|gb|ABP43852.1| beta-lactamase domain protein [Mycobacterium gilvum PYR-GCK] Length=257 Score = 375 bits (962), Expect = 4e-102, Method: Compositional matrix adjust. Identities = 193/256 (76%), Positives = 216/256 (85%), Gaps = 1/256 (0%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDD-DEHLA 66 + HPAY LR VTDTASVLL +NPGL+TLDGTNTWVLRGP SDE+VVVDPGPDD DEH+ Sbjct 1 MEHPAYNVLRPVTDTASVLLCENPGLMTLDGTNTWVLRGPGSDEMVVVDPGPDDKDEHIE 60 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 R+AALGRI+LVLISHRHGDHT GID+LV +TGA VR+ F R G TLTDGEVID AG Sbjct 61 RLAALGRISLVLISHRHGDHTGGIDRLVDMTGAVVRSVGSGFQRGLGGTLTDGEVIDAAG 120 Query 127 LTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGR 186 L ITV+ATPGHTADS+SF++DDAVLTADTVLG GTTVID EDG L DYLESL RLRGLG Sbjct 121 LAITVMATPGHTADSVSFLVDDAVLTADTVLGRGTTVIDSEDGDLGDYLESLRRLRGLGH 180 Query 187 RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKL 246 TVLPGHGP+L D+ A++ YL HR ERL Q+R AL LG+DAT R+VVEHVY DVDEKL Sbjct 181 LTVLPGHGPELDDMAAVSEFYLAHREERLAQVRGALGALGEDATARQVVEHVYTDVDEKL 240 Query 247 WNAAEWSVQAQLDYLR 262 W+AAEWSVQAQL+YLR Sbjct 241 WDAAEWSVQAQLNYLR 256 >gi|315446302|ref|YP_004079181.1| Zn-dependent hydrolase, glyoxylase [Mycobacterium sp. Spyr1] gi|315264605|gb|ADU01347.1| Zn-dependent hydrolase, glyoxylase [Mycobacterium sp. Spyr1] Length=257 Score = 374 bits (960), Expect = 7e-102, Method: Compositional matrix adjust. Identities = 193/256 (76%), Positives = 215/256 (84%), Gaps = 1/256 (0%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDD-DEHLA 66 + HPAY LR VTDTASVLL +NPGL+TLDGTNTWVLRGP SDE+VVVDPGPDD DEH+ Sbjct 1 MEHPAYNVLRPVTDTASVLLCENPGLMTLDGTNTWVLRGPGSDEMVVVDPGPDDKDEHIE 60 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 R+AALGRI LVLISHRHGDHT GID+LV +TGA VR+ F R G TLTDGEVID AG Sbjct 61 RLAALGRITLVLISHRHGDHTGGIDRLVDMTGAVVRSVGSGFQRGLGGTLTDGEVIDAAG 120 Query 127 LTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGR 186 L ITV+ATPGHTADS+SF++DDAVLTADTVLG GTTVID EDG L DYLESL RLRGLG Sbjct 121 LAITVMATPGHTADSVSFLVDDAVLTADTVLGRGTTVIDSEDGDLGDYLESLRRLRGLGH 180 Query 187 RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKL 246 TVLPGHGP+L D+ A++ YL HR ERL Q+R AL LG+DAT R+VVEHVY DVDEKL Sbjct 181 LTVLPGHGPELDDMAAVSEFYLAHREERLAQVRGALGALGEDATARQVVEHVYTDVDEKL 240 Query 247 WNAAEWSVQAQLDYLR 262 W+AAEWSVQAQL+YLR Sbjct 241 WDAAEWSVQAQLNYLR 256 >gi|118473784|ref|YP_890410.1| metallo-beta-lactamase [Mycobacterium smegmatis str. MC2 155] gi|118175071|gb|ABK75967.1| metallo-beta-lactamase family protein [Mycobacterium smegmatis str. MC2 155] Length=264 Score = 373 bits (958), Expect = 1e-101, Method: Compositional matrix adjust. Identities = 196/260 (76%), Positives = 215/260 (83%), Gaps = 5/260 (1%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLAR 67 L HPAYG LR VT +ASVLL +NPGL+TL+GTNTWVLR P SDE+VVVDPGPDDDEH+AR Sbjct 4 LQHPAYGLLRPVTGSASVLLCNNPGLMTLEGTNTWVLRAPRSDEIVVVDPGPDDDEHIAR 63 Query 68 VAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGL 127 VA LG I+LVLISH+H DHT GIDK+V TGA VR+ FLR G LTDGEVID AGL Sbjct 64 VAELGTISLVLISHKHEDHTGGIDKIVERTGAVVRSVGSGFLRGLGGPLTDGEVIDAAGL 123 Query 128 TITVLATPGHTADSLSFVLDD-----AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLR 182 ITV+ATPGHTADSLSFVLDD AVLTADTVLG GTTVID EDGSL DYL+SLHRL+ Sbjct 124 RITVMATPGHTADSLSFVLDDGDGPGAVLTADTVLGRGTTVIDTEDGSLRDYLDSLHRLK 183 Query 183 GLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDV 242 GLG R VLPGHGP+L DL +A YL HR ERLEQ+R ALR+LGDDAT R+VVEHVY DV Sbjct 184 GLGERVVLPGHGPELGDLSGVAQMYLAHREERLEQVREALRELGDDATARQVVEHVYTDV 243 Query 243 DEKLWNAAEWSVQAQLDYLR 262 DEKLW+AAE SVQAQLDYLR Sbjct 244 DEKLWDAAEKSVQAQLDYLR 263 >gi|120406383|ref|YP_956212.1| beta-lactamase domain-containing protein [Mycobacterium vanbaalenii PYR-1] gi|119959201|gb|ABM16206.1| beta-lactamase domain protein [Mycobacterium vanbaalenii PYR-1] Length=257 Score = 365 bits (938), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 190/256 (75%), Positives = 214/256 (84%), Gaps = 1/256 (0%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDD-DEHLA 66 + HPAYG LR VTDTASVLL +NPGL+TLDGTNTWVLRGP SDE+VVVDPGPDD DEH+ Sbjct 1 MEHPAYGLLRPVTDTASVLLCENPGLMTLDGTNTWVLRGPGSDEMVVVDPGPDDRDEHIE 60 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 R+AALG I LVLISHRH DHT GID++V LTGA VR+ F R G TLTDGEVID AG Sbjct 61 RLAALGPIPLVLISHRHADHTGGIDRIVDLTGAVVRSVGSGFQRGLGGTLTDGEVIDAAG 120 Query 127 LTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGR 186 L ITV+ATPGHTADS+SF++ DAVLTADT+LG GTTVID EDG L DYLESL RL GLG Sbjct 121 LKITVMATPGHTADSMSFLVGDAVLTADTILGRGTTVIDSEDGDLGDYLESLRRLHGLGH 180 Query 187 RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKL 246 R VLPGHGP+L D+ ++ YL HR ERLEQ+RAALR+LG+DAT R+VVEHVY DVDEKL Sbjct 181 RRVLPGHGPELDDVVVVSQDYLTHREERLEQVRAALRELGEDATARQVVEHVYTDVDEKL 240 Query 247 WNAAEWSVQAQLDYLR 262 W+AAE SVQAQLD+LR Sbjct 241 WDAAESSVQAQLDHLR 256 >gi|336460827|gb|EGO39712.1| Zn-dependent hydrolase, glyoxylase [Mycobacterium avium subsp. paratuberculosis S397] Length=252 Score = 363 bits (932), Expect = 1e-98, Method: Compositional matrix adjust. Identities = 195/248 (79%), Positives = 219/248 (89%), Gaps = 0/248 (0%) Query 16 LRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIA 75 +RAVTDTASVLLADNPGLLTL+GTNTWVLRG SDELV+VDPGPDDDEH+AR+AALGRIA Sbjct 1 MRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVIVDPGPDDDEHIARIAALGRIA 60 Query 76 LVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATP 135 LVLISHRHGDHT GIDKLV TGA VR+A FLR G LTDGEVID AGL I V+ATP Sbjct 61 LVLISHRHGDHTDGIDKLVGRTGAIVRSAGSGFLRGLGGELTDGEVIDAAGLRIKVMATP 120 Query 136 GHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVLPGHGP 195 GHTADSL F+LDDAVLTADTVLG GTTV+DKEDGSL DYLESL RLRGLGRR VLPGHGP Sbjct 121 GHTADSLCFLLDDAVLTADTVLGRGTTVLDKEDGSLTDYLESLRRLRGLGRRAVLPGHGP 180 Query 196 DLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKLWNAAEWSVQ 255 DL DLE++A GYL HR ERL+Q+R+A+R+LG+D + R +VEHVY+DVDEKLW+AAEWSVQ Sbjct 181 DLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYVDVDEKLWDAAEWSVQ 240 Query 256 AQLDYLRT 263 QL++LR+ Sbjct 241 VQLNHLRS 248 >gi|169627518|ref|YP_001701167.1| beta-lactamase-like hydrolase [Mycobacterium abscessus ATCC 19977] gi|169239485|emb|CAM60513.1| Possible hydrolase (beta-lactamase-like) [Mycobacterium abscessus] Length=261 Score = 359 bits (922), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 180/259 (70%), Positives = 214/259 (83%), Gaps = 5/259 (1%) Query 10 HPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGP-----DDDEH 64 HPAYGQLR VT+TASVLLA+NPG++TL+GTNTWVLR P SDE+V+VDPGP D D H Sbjct 2 HPAYGQLRPVTETASVLLANNPGMMTLEGTNTWVLRAPGSDEIVIVDPGPGVATGDPDVH 61 Query 65 LARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDV 124 + ++A +G++ALVL+SHRH DHT G+D+LV LTGAP RA DP +LR D LTDGE IDV Sbjct 62 VEQLAKIGKVALVLVSHRHFDHTGGVDRLVELTGAPARAVDPAWLRGDSVALTDGERIDV 121 Query 125 AGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGL 184 AGL+I+VLATPGH+ DS+SFVLDDAVLTADT+LG GTTVI ++ G L DYLESL RL GL Sbjct 122 AGLSISVLATPGHSDDSVSFVLDDAVLTADTILGRGTTVIAQDGGGLGDYLESLKRLEGL 181 Query 185 GRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDE 244 G+RTVLPGHGP+L DL A ++ YL HR +RL+Q+RAAL LG+DA+ R+VVE VY DVD Sbjct 182 GKRTVLPGHGPELSDLSAASAEYLAHREQRLDQVRAALAALGEDASARQVVEFVYTDVDP 241 Query 245 KLWNAAEWSVQAQLDYLRT 263 LW AAEWSVQAQLDYLRT Sbjct 242 SLWGAAEWSVQAQLDYLRT 260 >gi|229492190|ref|ZP_04385999.1| beta-lactamase domain protein [Rhodococcus erythropolis SK121] gi|229320978|gb|EEN86790.1| beta-lactamase domain protein [Rhodococcus erythropolis SK121] Length=261 Score = 301 bits (772), Expect = 5e-80, Method: Compositional matrix adjust. Identities = 164/259 (64%), Positives = 193/259 (75%), Gaps = 3/259 (1%) Query 7 SLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA 66 S HPAY QLR VTD ASVLL +NPG++TLDGTNTW+L P S E VVVDPG +D+EHL Sbjct 2 STVHPAYEQLRRVTDIASVLLENNPGMMTLDGTNTWILHAPGSVECVVVDPGDNDEEHLQ 61 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 RVA +G +AL LI+HRH DHT G+D+ LT APVR+ DP FLR L DGEVI+VAG Sbjct 62 RVAGIGPVALTLITHRHYDHTGGVDRFHELTSAPVRSVDPTFLRGGASALVDGEVIEVAG 121 Query 127 LTITVLATPGHTADSLSFVLDD--AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGL 184 L + +LATPGHTADS+S V+++ +VLT DT+LG GT V+D DG L DYL SL L L Sbjct 122 LKLRILATPGHTADSVSIVIENDASVLTGDTILGRGTAVLDDSDGDLGDYLTSLRSLAAL 181 Query 185 GRR-TVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVD 243 G TVLPGHGPDL DL+AI+ YL HR ERL+Q+RAAL LG+ A+VR+VVEHVY DVD Sbjct 182 GEGLTVLPGHGPDLPDLQAISQQYLAHREERLDQVRAALSTLGESASVRDVVEHVYSDVD 241 Query 244 EKLWNAAEWSVQAQLDYLR 262 KLW AE SV QL YLR Sbjct 242 PKLWPVAEKSVNVQLAYLR 260 >gi|226303958|ref|YP_002763916.1| beta-lactamase [Rhodococcus erythropolis PR4] gi|226183073|dbj|BAH31177.1| putative beta-lactamase [Rhodococcus erythropolis PR4] Length=261 Score = 301 bits (770), Expect = 9e-80, Method: Compositional matrix adjust. Identities = 164/259 (64%), Positives = 191/259 (74%), Gaps = 3/259 (1%) Query 7 SLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA 66 S HPAY QLR VTD ASVLL +NPG++TLDGTNTW+L P S E VVVDPG +D+EHL Sbjct 2 STVHPAYAQLRRVTDIASVLLENNPGMMTLDGTNTWILHAPGSVECVVVDPGDNDEEHLQ 61 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 RVA +G +AL LI+HRH DHT G+D+ LT APVR+ DP FLR L DGEVI+VAG Sbjct 62 RVAGIGPVALTLITHRHYDHTGGVDRFHELTSAPVRSVDPTFLRGGASALVDGEVIEVAG 121 Query 127 LTITVLATPGHTADSLSFVLDD--AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGL 184 L + +LATPGHTADS+S V+++ +VLT DT+LG GT V+D DG L DYL SL L L Sbjct 122 LKLRILATPGHTADSVSIVIENDASVLTGDTILGRGTAVLDDTDGDLGDYLTSLRSLAAL 181 Query 185 GR-RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVD 243 G TVLPGHGPDL DL+AI+ YL HR ERL Q+R AL LG+ A+VREVVEHVY DVD Sbjct 182 GEGLTVLPGHGPDLPDLQAISQQYLAHREERLAQVRDALTTLGESASVREVVEHVYSDVD 241 Query 244 EKLWNAAEWSVQAQLDYLR 262 KLW AE SV QL YLR Sbjct 242 PKLWPVAEKSVNVQLAYLR 260 >gi|226363640|ref|YP_002781422.1| beta-lactamase [Rhodococcus opacus B4] gi|226242129|dbj|BAH52477.1| putative beta-lactamase [Rhodococcus opacus B4] Length=263 Score = 297 bits (760), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 163/262 (63%), Positives = 189/262 (73%), Gaps = 5/262 (1%) Query 7 SLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA 66 +L HP Y Q+R VT SV+L DNPG++TLDGTNTW+LR P E VVVDPG D+EHLA Sbjct 2 TLAHPTYAQVREVTPIVSVMLEDNPGMMTLDGTNTWILRAPGRGECVVVDPGDADEEHLA 61 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 RVAALG +AL LI+HRH DHT G+ + LTGAPVR+ DP+FLR GE L DGE IDVAG Sbjct 62 RVAALGPVALTLITHRHFDHTGGVQRFFELTGAPVRSVDPEFLRGGGEPLVDGETIDVAG 121 Query 127 LTITVLATPGHTADSLSFVLD--DAVLTADTVLGCGTTVIDKEDGSLADY--LESLHRLR 182 LT+TV+ATPGHT DS+SF +D AVLT DT+LG GTTV+D DG L DY Sbjct 122 LTLTVIATPGHTKDSVSFTVDGEGAVLTGDTILGRGTTVLDDSDGDLGDYLSSLRRLLDL 181 Query 183 GLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDV 242 G G R V+PGHGP+L +L +A YL HR ERL+Q+RAAL LG TVREVVEHVY DV Sbjct 182 GTGHR-VMPGHGPELPELNVVAQQYLDHREERLDQVRAALGALGGTPTVREVVEHVYSDV 240 Query 243 DEKLWNAAEWSVQAQLDYLRTR 264 D KLW AE SV QL YLR+R Sbjct 241 DPKLWPVAEKSVNVQLAYLRSR 262 >gi|111021296|ref|YP_704268.1| hydrolase [Rhodococcus jostii RHA1] gi|110820826|gb|ABG96110.1| possible hydrolase [Rhodococcus jostii RHA1] Length=263 Score = 296 bits (759), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 161/261 (62%), Positives = 190/261 (73%), Gaps = 5/261 (1%) Query 7 SLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA 66 +L HPAY Q+R VT SV+L +NPG++TLDGTNTW+LR P DE VVVDPG D+EHLA Sbjct 2 TLAHPAYAQVREVTPIVSVMLENNPGMMTLDGTNTWILRAPGRDECVVVDPGDADEEHLA 61 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 RVAALG +AL LI+HRH DHT G+ + LTGAPVR+ DP+FLR GETL DGE IDVAG Sbjct 62 RVAALGPVALTLITHRHFDHTGGVQRFFELTGAPVRSVDPEFLRGGGETLVDGETIDVAG 121 Query 127 LTITVLATPGHTADSLSFVL--DDAVLTADTVLGCGTTVIDKEDGSLADY--LESLHRLR 182 LT+TV+ATPGHT DS+SF + + VLT DT+LG GTTV+D DG L DY Sbjct 122 LTLTVIATPGHTKDSVSFTVEGEGTVLTGDTILGRGTTVLDDTDGDLGDYLSSLRRLLDL 181 Query 183 GLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDV 242 G G R V+PGHGP+L +L +A YL HR ERL+Q+RAA+ LG TVREVVEHVY DV Sbjct 182 GTGHR-VMPGHGPELPELNVVAQQYLDHREERLDQVRAAIEALGGTPTVREVVEHVYSDV 240 Query 243 DEKLWNAAEWSVQAQLDYLRT 263 D KLW AE SV QL YLR+ Sbjct 241 DPKLWPVAEKSVNVQLAYLRS 261 >gi|54022309|ref|YP_116551.1| putative hydrolase [Nocardia farcinica IFM 10152] gi|54013817|dbj|BAD55187.1| putative hydrolase [Nocardia farcinica IFM 10152] Length=266 Score = 295 bits (754), Expect = 6e-78, Method: Compositional matrix adjust. Identities = 163/263 (62%), Positives = 195/263 (75%), Gaps = 3/263 (1%) Query 5 AESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEH 64 A +LTHPAYG++R VT TA+VLLADNPG +TLDGTNTW+LR P + E VVVDPGP D +H Sbjct 3 AMTLTHPAYGRVRQVTPTAAVLLADNPGQMTLDGTNTWLLRAPGATEYVVVDPGPKDKKH 62 Query 65 LARVAAL--GRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVI 122 + A GRIAL LI+H H DHT GID+LV LTGAPV AADP +L L D V+ Sbjct 63 TEAILAATDGRIALTLITHHHHDHTGGIDRLVKLTGAPVTAADPGYLHGWDTPLADDAVL 122 Query 123 DVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLR 182 + AGL I LATPGHT+DS+SFVLDDAV+T DT+LG GTTV++ G+LADYL+SL RL Sbjct 123 EAAGLRIRTLATPGHTSDSVSFVLDDAVITGDTILGSGTTVLESRSGALADYLDSLDRLL 182 Query 183 GLGR-RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLD 241 G + +LP HGPD DL +A Y+ HRHERL+Q+RAALR+LG DA VV VY D Sbjct 183 AEGSGKALLPAHGPDHADLAPVAQYYVKHRHERLDQVRAALRELGADAGAMAVVRKVYAD 242 Query 242 VDEKLWNAAEWSVQAQLDYLRTR 264 VD++LW AA SVQAQLDYLR+R Sbjct 243 VDKRLWPAARSSVQAQLDYLRSR 265 >gi|333917942|ref|YP_004491523.1| hydrolase [Amycolicicoccus subflavus DQS3-9A1] gi|333480163|gb|AEF38723.1| Hydrolase [Amycolicicoccus subflavus DQS3-9A1] Length=264 Score = 285 bits (729), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 157/263 (60%), Positives = 183/263 (70%), Gaps = 6/263 (2%) Query 7 SLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA 66 +L HPAYG +R V+ ASV LA+NPG +TLDGTNTW+LR P S V+VDPGPDD+ HL Sbjct 2 TLEHPAYGAIREVSAFASVALAENPGYMTLDGTNTWILRAPDSPGCVIVDPGPDDEAHLR 61 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 RVA+ G + LVLI+HRH DHT GID L L APVR P RD L GE IDV+G Sbjct 62 RVASAGPVDLVLITHRHIDHTEGIDSLARLVQAPVRGLRPDDC-RDSPPLAAGERIDVSG 120 Query 127 LTITVLATPGHTADSLSFVLD----DAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLR 182 LTI VL+ PGHTADS+ F D A+LT DT+LG GTTV+D DG L YLE+L R+ Sbjct 121 LTIEVLSAPGHTADSMMFTADVSGERALLTGDTILGRGTTVLDAYDGDLGAYLETLERIL 180 Query 183 GLGRRTV-LPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLD 241 LG + LPGHGP+ D+ A+A Y HR ERLEQIRAALR LG+D T REVVEHVY D Sbjct 181 NLGPGVIGLPGHGPETADVAAVALEYKAHREERLEQIRAALRVLGEDVTAREVVEHVYSD 240 Query 242 VDEKLWNAAEWSVQAQLDYLRTR 264 V + LW AAE SV+ QL YLR R Sbjct 241 VGQHLWPAAEASVRVQLTYLRQR 263 >gi|312137976|ref|YP_004005312.1| metallo-beta-lactamase superfamily protein [Rhodococcus equi 103S] gi|325675300|ref|ZP_08154985.1| metallo-beta-lactamase [Rhodococcus equi ATCC 33707] gi|311887315|emb|CBH46626.1| metallo-beta-lactamase superfamily protein [Rhodococcus equi 103S] gi|325554006|gb|EGD23683.1| metallo-beta-lactamase [Rhodococcus equi ATCC 33707] Length=261 Score = 283 bits (723), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 162/259 (63%), Positives = 190/259 (74%), Gaps = 3/259 (1%) Query 7 SLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA 66 +L HPAY QLR VT A+V+L NP + +LDGTNTW+LR P DE +VVDPG DD +HLA Sbjct 2 TLQHPAYAQLRQVTPVAAVMLEQNPSMYSLDGTNTWILRAPGGDECIVVDPGDDDPDHLA 61 Query 67 RVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAG 126 RVA +G + L LISHRH DHT GID+ LTGAPVRA +F R G L E+I+ AG Sbjct 62 RVAGVGTVVLTLISHRHHDHTGGIDRFFELTGAPVRAVHEEFRRGGGGGLDHDELIEAAG 121 Query 127 LTITVLATPGHTADSLSFVL--DDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGL 184 LT+ VL TPGHTADS+SFV+ + +VLTADT+LG GTTV+D DG+L DYL S+ L L Sbjct 122 LTLRVLRTPGHTADSVSFVIEGEGSVLTADTILGRGTTVLDASDGNLRDYLASMQTLIDL 181 Query 185 GR-RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVD 243 G RTVLPGHGP+L DLEA+A YL HR ERL Q+R AL LG DA VR VVEHVY DVD Sbjct 182 GPGRTVLPGHGPELPDLEAVAKYYLAHREERLAQVRGALDALGADADVRAVVEHVYTDVD 241 Query 244 EKLWNAAEWSVQAQLDYLR 262 E LW AAE SV+ QL+YLR Sbjct 242 ETLWPAAEQSVRVQLEYLR 260 >gi|256374403|ref|YP_003098063.1| beta-lactamase domain-containing protein [Actinosynnema mirum DSM 43827] gi|255918706|gb|ACU34217.1| beta-lactamase domain protein [Actinosynnema mirum DSM 43827] Length=266 Score = 280 bits (715), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 151/258 (59%), Positives = 176/258 (69%), Gaps = 2/258 (0%) Query 6 ESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHL 65 E HPAYG LR VT A+VLLADNP ++TLDGTNTWVLR P + VVVDPGP D+ HL Sbjct 9 ERFEHPAYGVLRPVTPEAAVLLADNPSVMTLDGTNTWVLRAPGEESCVVVDPGPSDEAHL 68 Query 66 ARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVA 125 AR A G +A VL++H H DH G + GAPVRA DP LR GE L G+V+ A Sbjct 69 ARAAGFGPVAQVLLTHGHPDHAEGAREFGERVGAPVRALDPA-LRLGGEGLAHGDVVAAA 127 Query 126 GLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLG 185 GL I V+ TPGHT+DSL F++ AVLT DT+LG GTT++ DG L DYLESL L L Sbjct 128 GLEIRVVGTPGHTSDSLCFLVGGAVLTGDTILGRGTTIVAHPDGRLGDYLESLRVLADLP 187 Query 186 R-RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDE 244 TVLPGHGP+L D A YL HR +RL Q+ AAL LG DAT R+VVE VY DVD Sbjct 188 PGTTVLPGHGPELPDAAEAARRYLAHREQRLAQVAAALEALGPDATARQVVESVYADVDR 247 Query 245 KLWNAAEWSVQAQLDYLR 262 LW AAEWSV+AQL++LR Sbjct 248 ALWPAAEWSVRAQLEHLR 265 >gi|134096939|ref|YP_001102600.1| metallo-beta-lactamase superfamily protein [Saccharopolyspora erythraea NRRL 2338] gi|291006619|ref|ZP_06564592.1| metallo-beta-lactamase superfamily protein [Saccharopolyspora erythraea NRRL 2338] gi|133909562|emb|CAL99674.1| metallo-beta-lactamase superfamily protein [Saccharopolyspora erythraea NRRL 2338] Length=275 Score = 263 bits (672), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 147/260 (57%), Positives = 179/260 (69%), Gaps = 7/260 (2%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLAR 67 + HPAYG +R VT ASVLLA NP ++TLDGTNTW++ P S + +V+DPGP D +HLA Sbjct 1 MEHPAYGAVRPVTAYASVLLARNPDVMTLDGTNTWLVGSPDSADRIVIDPGPADRDHLA- 59 Query 68 VAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGL 127 +AA +++VL++H H DHT+G LTGAPVRA DP L E LTDGE ++ +G+ Sbjct 60 LAAERPVSVVLLTHHHPDHTAGARDFAGLTGAPVRALDPA-LCAGAEPLTDGETVEASGV 118 Query 128 TITVLATPGHTADSLSFVLDD----AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRG 183 + VLATPGHTADS+ F +DD AV T DTVLG GTTV+ DG L YLESL L Sbjct 119 RLRVLATPGHTADSVCFTVDDPAEPAVFTGDTVLGKGTTVVAHPDGHLGSYLESLRLLGD 178 Query 184 LGRRT-VLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDV 242 L T VLPGHGP+L D+ A++ YL HR +RL QIR LR+ G D T R VVE VY DV Sbjct 179 LPEGTRVLPGHGPELPDIRAVSRAYLAHRGQRLGQIRTVLREHGPDITARGVVEIVYADV 238 Query 243 DEKLWNAAEWSVQAQLDYLR 262 D +W AAEWSVQAQL YLR Sbjct 239 DPAVWPAAEWSVQAQLTYLR 258 >gi|296141601|ref|YP_003648844.1| beta-lactamase [Tsukamurella paurometabola DSM 20162] gi|296029735|gb|ADG80505.1| beta-lactamase domain protein [Tsukamurella paurometabola DSM 20162] Length=276 Score = 262 bits (669), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 144/270 (54%), Positives = 183/270 (68%), Gaps = 14/270 (5%) Query 6 ESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHL 65 E THPA +LRAVT A+VLL DNP ++TL+GTNTW+LR P +E VVVDPGP+D +HL Sbjct 3 EPRTHPAPKKLRAVTPYAAVLLCDNPSVMTLEGTNTWILRAPGREEAVVVDPGPNDKKHL 62 Query 66 ARVA-ALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDV 124 RVA A G++AL L++HRH DHT G+ + LT +P+RA P++ LT GE IDV Sbjct 63 KRVAKAAGKVALTLVTHRHRDHTGGLRRWEELTRSPIRAFSPKYCVNTATPLTGGEQIDV 122 Query 125 AGLTITVLATPGHTADSLSFVLD---------DAVLTADTVLGCGTTVIDKEDGSLADYL 175 AGL I V+ TPGHT DSLSF++D A+++ DT+LG GTTV+D EDG+LADYL Sbjct 123 AGLRIRVVHTPGHTFDSLSFLVDWEDSDGAVPGALISGDTLLGRGTTVLDAEDGTLADYL 182 Query 176 ESLHRLRGLGR-RTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDL---GDDATV 231 SL L + R +LPGHGPDL D + S Y HR +RL+Q+R AL +L DA Sbjct 183 ASLDTLATVAAGRVLLPGHGPDLPDAGPVVSAYTAHRQDRLQQVRDALEELNLTAADAKP 242 Query 232 REVVEHVYLDVDEKLWNAAEWSVQAQLDYL 261 +VV+HVY DVD+K W AA SV+ QL YL Sbjct 243 MKVVKHVYRDVDKKAWPAARQSVKVQLAYL 272 >gi|343926472|ref|ZP_08765977.1| putative beta-lactamase [Gordonia alkanivorans NBRC 16433] gi|343763710|dbj|GAA12903.1| putative beta-lactamase [Gordonia alkanivorans NBRC 16433] Length=273 Score = 260 bits (665), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 153/264 (58%), Positives = 183/264 (70%), Gaps = 12/264 (4%) Query 9 THPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLA-R 67 THPAYG LR VT ASVLL DN G++ LDGTNT+VLR P SDE VVVDPGP +H A R Sbjct 10 THPAYGVLREVTPFASVLLCDNSGMMELDGTNTYVLRAPGSDECVVVDPGPPKYKHHARR 69 Query 68 VAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGL 127 +A L +AL LI+HRH DHT G+ +L TGAPVRA +F R+ E L D EVI++AGL Sbjct 70 LAELPGVALTLITHRHFDHTGGVKRLHQRTGAPVRARLDKFC-RNAEPLRDREVIEIAGL 128 Query 128 TITVLATPGHTADSLSFVLDD----AVLTADTVLGCGTTVIDKEDGSLADYLESLHRL-- 181 ITVL TPGHT DS+SF+++ AVLT DT+LG GTTV+D DG L DYL SL+RL Sbjct 129 RITVLHTPGHTGDSVSFLVEHDDQRAVLTGDTILGSGTTVLDPSDGGLRDYLNSLNRLIV 188 Query 182 RGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLG---DDATVREVVEHV 238 G G +LP HGPD DL +A Y HR ER++QI AAL D+G +A +VV V Sbjct 189 EGDG-AALLPAHGPDHPDLVPVARFYKAHREERIDQIVAALDDMGVSPHEAKPMKVVRRV 247 Query 239 YLDVDEKLWNAAEWSVQAQLDYLR 262 Y DVD+KLW AA SV+AQL+YLR Sbjct 248 YSDVDKKLWPAARMSVKAQLEYLR 271 >gi|324999015|ref|ZP_08120127.1| beta-lactamase domain protein [Pseudonocardia sp. P1] Length=262 Score = 258 bits (659), Expect = 7e-67, Method: Compositional matrix adjust. Identities = 146/262 (56%), Positives = 182/262 (70%), Gaps = 8/262 (3%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLAR 67 ++HP YG LRAV ASVLL DNPG +TLDGTNTWV+ P S + +VVDPG DD HL Sbjct 1 MSHPLYGSLRAVHPLASVLLQDNPGPMTLDGTNTWVVAVPDSGQRIVVDPGEDDGTHLEA 60 Query 68 VAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGL 127 +A +A V+++HRH DH G+ + V LTGAPV AADP L + LTDG VI AG+ Sbjct 61 LADGAPVAAVVLTHRHHDHAGGVGRFVELTGAPVYAADPS-LAVGTDPLTDGTVIAGAGV 119 Query 128 TITVLATPGHTADSLSFVLD------DAVLTADTVLGCGTTVIDKEDGSLADYLESLHRL 181 +TV+ TPGHT+DS+S +L+ A+L DTVLG GTTVI DG+L YLESL R+ Sbjct 120 ELTVMTTPGHTSDSVSLLLEGPGSDGPALLAGDTVLGRGTTVIAHPDGALGPYLESLRRI 179 Query 182 RGLGRRTVL-PGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL 240 L T L PGHGP+L D IA+ YL HR +RL+Q+RAAL +LG ++T R+VVE VY Sbjct 180 AELPAGTPLFPGHGPELPDAAEIANAYLAHREQRLDQVRAALEELGPESTARDVVEVVYA 239 Query 241 DVDEKLWNAAEWSVQAQLDYLR 262 DVD LW+AAE SV+AQLD+LR Sbjct 240 DVDTSLWDAAELSVRAQLDHLR 261 >gi|262200519|ref|YP_003271727.1| beta-lactamase [Gordonia bronchialis DSM 43247] gi|262083866|gb|ACY19834.1| beta-lactamase domain protein [Gordonia bronchialis DSM 43247] Length=267 Score = 254 bits (650), Expect = 7e-66, Method: Compositional matrix adjust. Identities = 144/262 (55%), Positives = 180/262 (69%), Gaps = 10/262 (3%) Query 10 HPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDD-DEHLARV 68 HPAYG+LR +T ASV+L DNPG++ LDGTNT+VLR P SDE VVVDPGP +H ++ Sbjct 5 HPAYGELREITPFASVILCDNPGMMELDGTNTYVLRAPGSDECVVVDPGPPKHKKHARQL 64 Query 69 AALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLT 128 A L +AL+LI+HRH DHT GI +L TGAP RA + R L D EVI+VAGL Sbjct 65 AELPGVALILITHRHFDHTGGISRLHKRTGAPTRARLAKHC-RGAAPLRDREVIEVAGLR 123 Query 129 ITVLATPGHTADSLSFVLDD----AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGL 184 ITVL TPGH+ DS+SF+++ A+LT DT+LG GTTV+D DG L DYL SL+RL Sbjct 124 ITVLFTPGHSGDSVSFLVEHDGERAMLTGDTILGSGTTVLDPSDGGLRDYLNSLNRLIVE 183 Query 185 GRRT-VLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLG---DDATVREVVEHVYL 240 G T +LP HGPD +L +A Y HR ER++QI AAL ++G +A +VV VY Sbjct 184 GENTKLLPAHGPDHPELIPVARFYKTHREERIDQIVAALDEMGVTAHEAKPMKVVRKVYR 243 Query 241 DVDEKLWNAAEWSVQAQLDYLR 262 DVD+KLW AA SV+AQL+YLR Sbjct 244 DVDKKLWPAARMSVKAQLEYLR 265 >gi|288918351|ref|ZP_06412704.1| beta-lactamase domain protein [Frankia sp. EUN1f] gi|288350246|gb|EFC84470.1| beta-lactamase domain protein [Frankia sp. EUN1f] Length=259 Score = 251 bits (641), Expect = 8e-65, Method: Compositional matrix adjust. Identities = 150/256 (59%), Positives = 174/256 (68%), Gaps = 9/256 (3%) Query 17 RAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIAL 76 R VT ASV LA NPG +TL+GTNTW+LR P VVVDPGPD DEHLARVAA G + Sbjct 5 REVTRLASVQLAPNPGPMTLEGTNTWILRAPGEPGCVVVDPGPDHDEHLARVAAAGPVHA 64 Query 77 VLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPG 136 +L++H H DH++G L ALTGA VRA DP R E L G+V+ AG+ + VLATPG Sbjct 65 ILLTHGHNDHSAGAAALHALTGAWVRALDPAH-RLGSEGLGAGDVVAAAGVELRVLATPG 123 Query 137 HTADSLSFVL--DD---AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVLP 191 HTADSLSFVL DD AVLT DT+LG G+TV+ DG L DYLESL LR LG TVLP Sbjct 124 HTADSLSFVLTGDDQHPAVLTGDTILGRGSTVVAHPDGRLGDYLESLRSLRELGDMTVLP 183 Query 192 GHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDA---TVREVVEHVYLDVDEKLWN 248 GHGP+L A YL HR RL+Q+ AAL +LG A T +VV VY DVD LW Sbjct 184 GHGPELPAAGRAAQAYLDHRAARLDQVSAALSELGRPAGEVTPSDVVRLVYADVDRALWP 243 Query 249 AAEWSVQAQLDYLRTR 264 AAE SV+AQL+YLR+R Sbjct 244 AAELSVRAQLEYLRSR 259 >gi|300790645|ref|YP_003770936.1| beta-lactamase class B [Amycolatopsis mediterranei U32] gi|299800159|gb|ADJ50534.1| beta-lactamase class B [Amycolatopsis mediterranei U32] gi|340532335|gb|AEK47540.1| beta-lactamase class B [Amycolatopsis mediterranei S699] Length=256 Score = 248 bits (633), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 141/257 (55%), Positives = 169/257 (66%), Gaps = 6/257 (2%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLAR 67 ++ PAYG LR V+ TASVLL +NP +TL+GTN+WVLR S VVVDPG D EHL Sbjct 1 MSAPAYGVLRQVSATASVLLENNPSSMTLEGTNSWVLRATPSSPAVVVDPGYRDLEHLEL 60 Query 68 VAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGL 127 +A +G + L+L++H H DH G GAPVRA DP L + DGE I GL Sbjct 61 LAGIGAVELILLTHCHPDHAEGAPWFAERVGAPVRAFDPS-LCVGTSSFVDGEEISAGGL 119 Query 128 TITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRR 187 ++ VL TPGHT DS+S VLD VLT DT+LG GTTV+ L DYL SL +L L Sbjct 120 SLRVLHTPGHTDDSVSLVLDGQVLTGDTILGRGTTVLHD----LGDYLRSLRKLIELPPG 175 Query 188 TV-LPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKL 246 T LPGHGP+L DL A YL HR +RL+Q+R+AL+ LG DAT R+VVE VY DVD L Sbjct 176 TAGLPGHGPELPDLPTTAREYLAHREQRLDQVRSALKTLGADATPRQVVEVVYADVDRAL 235 Query 247 WNAAEWSVQAQLDYLRT 263 W AEWSVQAQLDYLR+ Sbjct 236 WAPAEWSVQAQLDYLRS 252 >gi|331700208|ref|YP_004336447.1| beta-lactamase domain-containing protein [Pseudonocardia dioxanivorans CB1190] gi|326954897|gb|AEA28594.1| beta-lactamase domain protein [Pseudonocardia dioxanivorans CB1190] Length=265 Score = 247 bits (631), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 152/260 (59%), Positives = 181/260 (70%), Gaps = 8/260 (3%) Query 10 HPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVA 69 HP+YG+LR VT ASVLLA NP +TL+GTNTWVLR P + VVVDPG D+EHLARVA Sbjct 4 HPSYGELRPVTALASVLLAHNPSPMTLEGTNTWVLRAPGEERCVVVDPGEHDEEHLARVA 63 Query 70 ALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTI 129 A G + LV+++H H DH G + LTGAPVRA DP + E L G+V+ AG+ + Sbjct 64 AQGPVELVILTHHHHDHAGGARRFAELTGAPVRALDPSLV-LGSEALAHGDVVAAAGVEL 122 Query 130 TVLATPGHTADSLSFVLD------DAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRG 183 +L+TPGHTADS+S VLD AVLT DT+LG GTTVI + DGSL YL+SL LR Sbjct 123 RILSTPGHTADSISLVLDGPGDPGPAVLTGDTILGRGTTVIAEPDGSLGPYLDSLRLLRE 182 Query 184 LGRRT-VLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDV 242 L T VLPGHGP+L D A A YL HR ERL+Q+R AL LG DAT R+VVE VY DV Sbjct 183 LPDGTDVLPGHGPELADAPAAARAYLAHREERLDQVRRALDTLGPDATPRQVVEIVYADV 242 Query 243 DEKLWNAAEWSVQAQLDYLR 262 D LW AA+ SV+AQL+YLR Sbjct 243 DPVLWKAADSSVKAQLEYLR 262 >gi|220913010|ref|YP_002488319.1| beta-lactamase [Arthrobacter chlorophenolicus A6] gi|219859888|gb|ACL40230.1| beta-lactamase domain protein [Arthrobacter chlorophenolicus A6] Length=275 Score = 247 bits (631), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 138/243 (57%), Positives = 164/243 (68%), Gaps = 5/243 (2%) Query 25 VLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIALVLISHRHG 84 +LA NPG ++LDGTN++VL P S VVVDPGPDD++HL +A + LVLI+HRH Sbjct 18 FILAPNPGPMSLDGTNSYVLAAPGSPTAVVVDPGPDDEDHLLALARAAAVELVLITHRHA 77 Query 85 DHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSF 144 DHT+G KL LTGAPVRAADP L DGEV+ AGL +TVLATPGHT+DS+ F Sbjct 78 DHTAGSSKLHQLTGAPVRAADPAHCHGGAAPLRDGEVVRAAGLELTVLATPGHTSDSVCF 137 Query 145 VL-----DDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVLPGHGPDLLD 199 L D +VLT DT+LG GTT++D DG+L DYL +L RL LG TVLP HGP L Sbjct 138 HLPGDGPDGSVLTGDTILGRGTTMLDYPDGTLGDYLATLDRLEALGPATVLPAHGPVLPS 197 Query 200 LEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKLWNAAEWSVQAQLD 259 L +A GY HRHERLEQIR AL LG DA+ +V + VY DV + AAE SV AQL Sbjct 198 LAEVARGYRAHRHERLEQIREALGRLGRDASAGDVADAVYSDVGPSVRRAAEMSVAAQLH 257 Query 260 YLR 262 YLR Sbjct 258 YLR 260 >gi|312194234|ref|YP_004014295.1| beta-lactamase domain protein [Frankia sp. EuI1c] gi|311225570|gb|ADP78425.1| beta-lactamase domain protein [Frankia sp. EuI1c] Length=282 Score = 246 bits (627), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 145/260 (56%), Positives = 173/260 (67%), Gaps = 20/260 (7%) Query 19 VTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIALVL 78 V A+V+LA NPG +TL+GTN+WVLR P D VV+DPGPD EHLA +AA G + +L Sbjct 24 VNPLAAVVLAPNPGPMTLEGTNSWVLRAPGHDGCVVIDPGPDYPEHLAAIAAAGPVTTIL 83 Query 79 ISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHT 138 ++H H DH+ G L LTGAPVRA DP R E L +G+V+ AG+ + VLATPGH+ Sbjct 84 LTHGHPDHSEGAAALHELTGAPVRALDPTH-RLGSEGLVEGDVVAAAGIELRVLATPGHS 142 Query 139 ADSLSFVLDD---------AVLTADTVLGCGTTVIDKEDGSLADYLESLHRL----RGLG 185 ADSLSF+L AVLT DT+LG GTTV+ DG LADYL SLHRL GLG Sbjct 143 ADSLSFLLFGDVPDGDEAVAVLTGDTILGRGTTVVAHPDGRLADYLASLHRLADLPTGLG 202 Query 186 RRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLG---DDATVREVVEHVYLDV 242 VLPGHGP+L D A A+ YL HR ERL+Q+RAAL G A+ R VVE VY DV Sbjct 203 ---VLPGHGPELADARAAATYYLAHRAERLDQVRAALTAAGVGPAQASPRAVVERVYADV 259 Query 243 DEKLWNAAEWSVQAQLDYLR 262 D LW AAE SV+AQL+YLR Sbjct 260 DRVLWPAAELSVRAQLEYLR 279 >gi|302530876|ref|ZP_07283218.1| beta-lactamase domain-containing protein [Streptomyces sp. AA4] gi|302439771|gb|EFL11587.1| beta-lactamase domain-containing protein [Streptomyces sp. AA4] Length=258 Score = 241 bits (616), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 138/256 (54%), Positives = 171/256 (67%), Gaps = 6/256 (2%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLAR 67 +T PAYG LR V++TASVLL +NP +TL+GTNTWVLRG + VVVDPG D EHL + Sbjct 1 MTAPAYGVLRRVSETASVLLENNPSTMTLEGTNTWVLRGGDAAGAVVVDPGYHDLEHLEK 60 Query 68 VAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGL 127 +AA+G + L+L++H H DH G + TGAPVRA D L D DG+V GL Sbjct 61 LAAVGPVELILLTHHHPDHAEGAPWFASKTGAPVRAFDAS-LCIDAPPFADGDVFSAGGL 119 Query 128 TITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRR 187 VL TPGHT DS+S ++ +LT DT+LG GTTV+ L DYL SL +L L Sbjct 120 DFRVLHTPGHTDDSVSLLVGGQILTGDTILGRGTTVLHD----LGDYLRSLRKLIALPDG 175 Query 188 TV-LPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKL 246 T LPGHGP+L DL A A YL HR +RL+Q+R+ALR LG++AT R+VVE VY DVD L Sbjct 176 TPGLPGHGPELPDLPATAQEYLAHREQRLDQVRSALRTLGENATPRQVVEVVYADVDRAL 235 Query 247 WNAAEWSVQAQLDYLR 262 W AE SV+AQL+YLR Sbjct 236 WAPAEASVRAQLEYLR 251 >gi|158312194|ref|YP_001504702.1| beta-lactamase domain-containing protein [Frankia sp. EAN1pec] gi|158107599|gb|ABW09796.1| beta-lactamase domain protein [Frankia sp. EAN1pec] Length=259 Score = 236 bits (603), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 151/257 (59%), Positives = 173/257 (68%), Gaps = 9/257 (3%) Query 16 LRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIA 75 LR VT ASV+LA NPG +TLDGTNTW+LR P VVVDPGPD EHLARVAA G + Sbjct 4 LRRVTKLASVVLAPNPGPMTLDGTNTWILRSPGDAGCVVVDPGPDHGEHLARVAAAGLVR 63 Query 76 LVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATP 135 +L++H H DH+ G L ALTGA VRA DP R E L G+V+ AG+ + VLATP Sbjct 64 TILLTHGHSDHSEGAATLHALTGAQVRALDPAH-RLGSEGLGAGDVVAAAGVELRVLATP 122 Query 136 GHTADSLSFVL--DD---AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVL 190 GHT+DSLSFVL DD AVLT DT+LG G+TV+ DG LADYL SL LR LG TVL Sbjct 123 GHTSDSLSFVLAGDDEHPAVLTGDTILGRGSTVVAHPDGRLADYLSSLRLLRELGDTTVL 182 Query 191 PGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDA---TVREVVEHVYLDVDEKLW 247 PGHGP+L A YL HR RL+Q+ +AL DLG A T +VV VY DVD LW Sbjct 183 PGHGPELPAAGRAAEAYLEHRARRLDQVISALADLGASAEQVTPIDVVRIVYADVDVALW 242 Query 248 NAAEWSVQAQLDYLRTR 264 AAE SV+AQLDYLR R Sbjct 243 PAAELSVRAQLDYLRPR 259 >gi|257057565|ref|YP_003135397.1| Zn-dependent hydrolase, glyoxylase [Saccharomonospora viridis DSM 43017] gi|256587437|gb|ACU98570.1| Zn-dependent hydrolase, glyoxylase [Saccharomonospora viridis DSM 43017] Length=258 Score = 234 bits (596), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 138/262 (53%), Positives = 172/262 (66%), Gaps = 10/262 (3%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLAR 67 + HPAYG LR V+ ASVLL +NP +TL+GTNTWVL+ P + +VVDPG D+HL Sbjct 1 MNHPAYGVLRPVSPIASVLLQNNPSTMTLEGTNTWVLQAPGAAGRIVVDPGHALDDHLET 60 Query 68 VAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGL 127 +A L I L+L++HRH DH L APVRA D L R G+ L DG+V+ AGL Sbjct 61 LAGLSGIELILLTHRHPDHVEAAPSLAERVDAPVRAFDAS-LCRGGDPLVDGDVVRAAGL 119 Query 128 TITVLATPGHTADSLSFVLDDA----VLTADTVLGCGTTVIDKEDGSLADYLESLHRLRG 183 T+ V+ TPGHT DS+ LD +T DTVLG GTTV+ L YL+SL +L Sbjct 120 TLQVVHTPGHTDDSIVLHLDHGGRTYAVTGDTVLGRGTTVLSD----LGGYLDSLRKLGE 175 Query 184 LGRRTV-LPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDV 242 L T+ LPGHGP+L DL + A+ YL HR +RL+Q+R ALR LGDDAT R+VVE VY DV Sbjct 176 LPPGTLGLPGHGPELSDLVSTAAEYLRHREQRLDQVRQALRKLGDDATARQVVELVYADV 235 Query 243 DEKLWNAAEWSVQAQLDYLRTR 264 D LW AE SV+AQL+YLR+R Sbjct 236 DPALWAPAEESVRAQLEYLRSR 257 >gi|317506664|ref|ZP_07964454.1| metallo-beta-lactamase superfamily protein [Segniliparus rugosus ATCC BAA-974] gi|316255047|gb|EFV14327.1| metallo-beta-lactamase superfamily protein [Segniliparus rugosus ATCC BAA-974] Length=291 Score = 234 bits (596), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 139/287 (49%), Positives = 176/287 (62%), Gaps = 29/287 (10%) Query 6 ESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHL 65 E+L HPAYG +R VT+ ASVLLA NP +TL+GTNTWVLR P S E VVVDPGP + H+ Sbjct 5 EALAHPAYGAVRPVTEQASVLLARNPSAMTLEGTNTWVLRAPGSQECVVVDPGPAEAAHV 64 Query 66 ARVAALGRIALVLISHRHGDHTSGIDKL-----------VALTGAPVRAA---DPQF--- 108 + ALG IA VL++H H DH + L VAL P AA P F Sbjct 65 EGILALGEIAAVLLTHHHFDHVRALPALRRRLAASGRSTVALAMNPSMAAKSQSPAFRLG 124 Query 109 LRRDGETLT-----DGEVIDVAGLTITVLATPGHTADSLSFVLD------DAVLTADTVL 157 + R G +L DG+ ++ AGL +T +ATPGHT+DS SF+L +AVLT DT+L Sbjct 125 MPRFGSSLRIGALGDGQTLEFAGLRVTAVATPGHTSDSTSFLLHGRDGGVEAVLTGDTIL 184 Query 158 GCGTTVIDKEDGSLADYLESLHRLRGLGRR-TVLPGHGPDLLDLEAIASGYLLHRHERLE 216 G G+T++D+ G L DYL S+ L +G T LPGHGP+L D+ A A+ L HR ERL+ Sbjct 185 GRGSTILDRRSGDLGDYLRSMRTLMSVGEGITGLPGHGPELSDVAAAAATGLRHREERLD 244 Query 217 QIRAALRDLGDDATVREVVEHVYLDVDEKLWNAAEWSVQAQLDYLRT 263 Q+RAAL LG A+ +V VY DVD KL AA S + QL YLR+ Sbjct 245 QVRAALAKLGSKASAWQVTREVYQDVDAKLLPAALSSTRVQLRYLRS 291 >gi|111225889|ref|YP_716683.1| putative hydrolase [Frankia alni ACN14a] gi|111153421|emb|CAJ65177.1| putative hydrolase [Frankia alni ACN14a] Length=280 Score = 234 bits (596), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 146/271 (54%), Positives = 168/271 (62%), Gaps = 26/271 (9%) Query 17 RAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIAL 76 R VT A+VLLA NPG +TLDGTNTW+LR VVVDPGPDD HLA VAA GR+ L Sbjct 5 RQVTPLAAVLLAPNPGPMTLDGTNTWLLRAAGEQGCVVVDPGPDDAGHLAAVAAAGRVEL 64 Query 77 VLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPG 136 +L++H H DH++G L LTGAPVRA DP R E LT G+VI AG+ + VL TPG Sbjct 65 ILLTHGHADHSAGAAALHRLTGAPVRALDPAH-RLGSEGLTAGDVIATAGIELRVLPTPG 123 Query 137 HTADSLSFVLD----------------------DAVLTADTVLGCGTTVIDKEDGSLADY 174 HT+DSLSF+L VLT DT+LG GTTV+ DG L DY Sbjct 124 HTSDSLSFLLSGDERPAPALPADAAGTAGLPSGPGVLTGDTILGRGTTVVAHPDGRLGDY 183 Query 175 LESLHRLRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDAT---V 231 L+SL LR LG TVLPGHGP+L A YL HR +RLEQ+R AL D G DA Sbjct 184 LDSLRLLRELGETTVLPGHGPELPAAGRAAEHYLAHRRDRLEQVRRALVDAGVDAAEADP 243 Query 232 REVVEHVYLDVDEKLWNAAEWSVQAQLDYLR 262 +VV VY D D LW AAE SV+AQLDYLR Sbjct 244 ADVVRRVYADTDRALWFAAELSVRAQLDYLR 274 >gi|336180121|ref|YP_004585496.1| putative hydrolase [Frankia symbiont of Datisca glomerata] gi|334861101|gb|AEH11575.1| putative hydrolase [Frankia symbiont of Datisca glomerata] Length=305 Score = 231 bits (588), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 141/280 (51%), Positives = 172/280 (62%), Gaps = 27/280 (9%) Query 9 THPAYG---QLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHL 65 T PA G R VT AS+LLA NP +TLDGTNTW+LR P + VVVDPGP D HL Sbjct 16 TTPAAGGRPAPRQVTLLASLLLAPNPSPMTLDGTNTWILRAPDATGCVVVDPGPPDPGHL 75 Query 66 ARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVA 125 + + A G + ++L++H H DH+ G L LT APVRA D D E LT+G+VI A Sbjct 76 SAIVAAGPVDVILLTHGHIDHSEGAAPLHELTSAPVRALDVAHQLGD-EGLTEGDVIAAA 134 Query 126 GLTITVLATPGHTADSLSFVLDD---------------------AVLTADTVLGCGTTVI 164 G+ I VLATPGH++DSLSFVL D +VLT DT+LG GTTV+ Sbjct 135 GVEIRVLATPGHSSDSLSFVLADDRRADTDGSDSTDISAPTAGSSVLTGDTILGRGTTVV 194 Query 165 DKEDGSLADYLESLHRLRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRD 224 DG L DYL SL RLR LG VLPGHGP L A YL HR RL+Q+RAAL Sbjct 195 AHPDGQLGDYLTSLRRLRELGDCVVLPGHGPHLPAAGRAAEAYLAHREVRLDQVRAAL-- 252 Query 225 LGDDATVREVVEHVYLDVDEKLWNAAEWSVQAQLDYLRTR 264 D+TVR++V+ +Y DVD LW AAE SV+AQ+++L R Sbjct 253 AAGDSTVRQIVQRIYTDVDRALWPAAEMSVRAQIEHLHQR 292 >gi|325963755|ref|YP_004241661.1| Zn-dependent hydrolase, glyoxylase [Arthrobacter phenanthrenivorans Sphe3] gi|323469842|gb|ADX73527.1| Zn-dependent hydrolase, glyoxylase [Arthrobacter phenanthrenivorans Sphe3] Length=266 Score = 230 bits (587), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 135/243 (56%), Positives = 159/243 (66%), Gaps = 5/243 (2%) Query 25 VLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIALVLISHRHG 84 +LA NPG ++LDGTN++V+R P S VVVDPGP D+ HL +AA G + L+LI+HRH Sbjct 18 FILAPNPGPMSLDGTNSYVVRAPASQAAVVVDPGPLDEAHLQALAAAGPVELILITHRHA 77 Query 85 DHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSF 144 DHT+G +L LTGAPVRAA P G L+DGE I AG+ I V ATPGHT+DS+ F Sbjct 78 DHTAGSARLHELTGAPVRAALPGHCHGGGALLSDGEEIHAAGVEIRVAATPGHTSDSVCF 137 Query 145 VL-----DDAVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVLPGHGPDLLD 199 L +VLT DT+LG GTT++D DG+L DYL SL RL LG TVLP HGP L Sbjct 138 HLPGDGSQGSVLTGDTILGRGTTMLDYPDGTLGDYLASLDRLEALGPATVLPAHGPVLPS 197 Query 200 LEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKLWNAAEWSVQAQLD 259 L A Y HR ERLEQIRAAL LG DA +V VY DVD + AAE SV AQL Sbjct 198 LVETARAYRSHRLERLEQIRAALDSLGRDAAAGDVAAVVYSDVDPSVRRAAETSVAAQLH 257 Query 260 YLR 262 YLR Sbjct 258 YLR 260 >gi|296393531|ref|YP_003658415.1| beta-lactamase [Segniliparus rotundus DSM 44985] gi|296180678|gb|ADG97584.1| beta-lactamase [Segniliparus rotundus DSM 44985] Length=291 Score = 230 bits (587), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 131/282 (47%), Positives = 173/282 (62%), Gaps = 29/282 (10%) Query 8 LTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLAR 67 L+HPAY +R VT+ ASVLLA NP ++TL+GTNTWVLR P + E VVVDPGPD +H+ R Sbjct 7 LSHPAYEVVRPVTERASVLLARNPSIMTLEGTNTWVLRAPGARECVVVDPGPDAADHVRR 66 Query 68 VAALGRIALVLISHRHGDHTSGIDKL--------------------VALTGAPVRAADPQ 107 +AALG +A VL++H H DH + L VA + +P+R P Sbjct 67 IAALGPVAAVLLTHHHADHVRALPALRRRLAASGREPVVLAVNPTMVAKSQSPLRFLAPS 126 Query 108 FLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSFVLD------DAVLTADTVLGCGT 161 R + DG+ + +AG+ +TV ATPGHT+DS SF++ +AVLT D +LG G+ Sbjct 127 S--RSINAVKDGQRLQIAGVRLTVAATPGHTSDSASFLVHGDQDEVEAVLTGDMILGYGS 184 Query 162 TVIDKEDGSLADYLESLHRLRGLGRRTV-LPGHGPDLLDLEAIASGYLLHRHERLEQIRA 220 TV+D+ G L DYL S+ +L +G V LPGHGP L D+ A A L HR ERLEQ+R+ Sbjct 185 TVLDRSSGDLGDYLRSMRKLMSVGEGVVGLPGHGPHLADVAAAAQDGLRHRQERLEQVRS 244 Query 221 ALRDLGDDATVREVVEHVYLDVDEKLWNAAEWSVQAQLDYLR 262 AL LG +A+ +V VY DVD KL +A S + QL YLR Sbjct 245 ALAKLGPNASAWKVTREVYRDVDAKLLPSALSSTKVQLRYLR 286 >gi|326383489|ref|ZP_08205176.1| beta-lactamase domain-containing protein [Gordonia neofelifaecis NRRL B-59395] gi|326197895|gb|EGD55082.1| beta-lactamase domain-containing protein [Gordonia neofelifaecis NRRL B-59395] Length=259 Score = 230 bits (586), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 137/256 (54%), Positives = 167/256 (66%), Gaps = 11/256 (4%) Query 17 RAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGP-DDDEHLARVAAL-GRI 74 R VT ASV+L DNPG LDGTNTW+LR P S VV+DPGP +H+ +VA + G + Sbjct 3 REVTPFASVVLCDNPGSFELDGTNTWILRAPGSPTAVVLDPGPAKHGKHVKKVAEVAGEV 62 Query 75 ALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLAT 134 LVLISHRH DH K+ L+GAP RA ++ L D EVI+ AGLTITVL T Sbjct 63 ELVLISHRHHDHVGACKKMRKLSGAPQRAYTDEY-SVGAPRLRDREVIEAAGLTITVLHT 121 Query 135 PGHTADSLSFVLD----DAVLTADTVLGCGTTVIDKEDGSLADYLESLHRL-RGLGRRTV 189 PGHTADS SF+++ A+L+ DT+LG GTTV+D DG+LADY SL+RL + Sbjct 122 PGHTADSTSFLVEWEGQRALLSGDTILGFGTTVLDPTDGTLADYFNSLNRLIVEASDAAL 181 Query 190 LPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLG---DDATVREVVEHVYLDVDEKL 246 LP HGPD +L IA Y HR ERL QI AAL DLG + A +VV VY DVD+KL Sbjct 182 LPAHGPDHPELGPIARYYKTHREERLAQIVAALDDLGVSPEKAKPMKVVRSVYADVDKKL 241 Query 247 WNAAEWSVQAQLDYLR 262 W AA+ SV+AQL+YLR Sbjct 242 WPAAKMSVKAQLEYLR 257 >gi|184199938|ref|YP_001854145.1| hypothetical protein KRH_02920 [Kocuria rhizophila DC2201] gi|183580168|dbj|BAG28639.1| putative beta-lactamase [Kocuria rhizophila DC2201] Length=288 Score = 228 bits (582), Expect = 6e-58, Method: Compositional matrix adjust. Identities = 136/276 (50%), Positives = 174/276 (64%), Gaps = 31/276 (11%) Query 14 GQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLS---------------------DEL 52 G L V+ A ++LA NPG +TLDGTNTW+L P S ++ Sbjct 11 GVLHRVSACAGMVLAPNPGPMTLDGTNTWILSAPGSGPEHPNYGQHPSAQGRGEWPGPDV 70 Query 53 VVVDPGPDDDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRD 112 VVVDPGP D++HL VAA GR+ L+L++HRH DHT GID+L +TGAPVRAA P+F R Sbjct 71 VVVDPGPLDEDHLQAVAATGRVVLILVTHRHRDHTDGIDRLHEITGAPVRAALPEFCRDS 130 Query 113 GETLTDGEVIDVAGLTITVLATPGHTADSLSFVL----DDAVLTADTVLGCGTTVIDKED 168 GE L DG+ + AG++I VLATPGHT+DS+SF+L + +LT DTVLG GTT+ID D Sbjct 131 GEPLRDGDFVLAAGVSIRVLATPGHTSDSVSFLLHHDEPETILTGDTVLGRGTTMIDHPD 190 Query 169 GSLADYLESLHRLRGLGRRT---VLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDL 225 G+L DYL SL R LGRR+ LP HG L L+ HR ERLEQ+R + DL Sbjct 191 GTLGDYLRSLER---LGRRSGAMGLPAHGAPLPGLQDACDELAEHRLERLEQVRGVVADL 247 Query 226 GDDATVREVVEHVYLDVDEKLWNAAEWSVQAQLDYL 261 G+ A+V V + VY DV ++ AAE S+ AQL +L Sbjct 248 GERASVETVTDAVYPDVPAEVRRAAEHSIAAQLAHL 283 >gi|116671074|ref|YP_832007.1| beta-lactamase domain-containing protein [Arthrobacter sp. FB24] gi|116611183|gb|ABK03907.1| beta-lactamase domain protein [Arthrobacter sp. FB24] Length=260 Score = 228 bits (580), Expect = 8e-58, Method: Compositional matrix adjust. Identities = 128/249 (52%), Positives = 164/249 (66%), Gaps = 6/249 (2%) Query 19 VTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIALVL 78 +D A LA NPG ++LDGT++++L P S+ VVVDPGP D+ HL +AA GR+ L+L Sbjct 12 ASDLARFRLAPNPGPMSLDGTSSYLLGRPGSETTVVVDPGPLDERHLQELAAAGRVELIL 71 Query 79 ISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHT 138 I+HRH DHT+ + LTGAPVRAAD + G L DGE + AG+ + V+A PGHT Sbjct 72 ITHRHADHTAAAGRFHELTGAPVRAADARHCH-GGNPLADGETLFAAGVELRVIAAPGHT 130 Query 139 ADSLSFVLDD-----AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVLPGH 193 +DSL F L +VLT DT+LG GTTV+D DG L DYL +L RL +G TVLPGH Sbjct 131 SDSLCFHLPGDGPHGSVLTGDTILGRGTTVLDFPDGKLGDYLATLDRLERIGPATVLPGH 190 Query 194 GPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLDVDEKLWNAAEWS 253 G L L+A+ Y HR ERL QIRAAL +LG DA + E+ + VY D+D + AAE S Sbjct 191 GAVLPALDAVVRAYRDHRQERLAQIRAALTELGPDAGLGEITDAVYADIDPAVRPAAENS 250 Query 254 VQAQLDYLR 262 V AQL++LR Sbjct 251 VAAQLEFLR 259 >gi|258650963|ref|YP_003200119.1| beta-lactamase domain-containing protein [Nakamurella multipartita DSM 44233] gi|258554188|gb|ACV77130.1| beta-lactamase domain protein [Nakamurella multipartita DSM 44233] Length=270 Score = 227 bits (579), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 149/265 (57%), Positives = 172/265 (65%), Gaps = 9/265 (3%) Query 6 ESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHL 65 + P L VT A+V LA NPG +TLDGTN++VL G V+VDPGP D HL Sbjct 2 NAANRPPRTALTPVTSHAAVRLAPNPGPMTLDGTNSYVLSGNGGRSSVIVDPGPGDPGHL 61 Query 66 ARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVA 125 +AA+G + L+LI+HRH DHT G +L A TGAPVRAADP F R GE L DGE++ A Sbjct 62 DALAAVGDVELILITHRHHDHTEGAAELAAATGAPVRAADPAFCR-GGEPLRDGELVAAA 120 Query 126 GLTITVLATPGHTADSLSFVLDD--------AVLTADTVLGCGTTVIDKEDGSLADYLES 177 GL I VLATPGHTADS+ F L AVLT DT+LG GTTVI DGSL DYL S Sbjct 121 GLPIEVLATPGHTADSVCFRLPSDSPDRPHGAVLTGDTILGRGTTVIAPPDGSLGDYLGS 180 Query 178 LHRLRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEH 237 L L LGR VLP HGP DL+A+A+ YL HR +RL+QIRAAL LG DA V V + Sbjct 181 LRVLAALGRAAVLPAHGPQQPDLQALAAAYLAHREQRLDQIRAALVQLGADADVAAVTDF 240 Query 238 VYLDVDEKLWNAAEWSVQAQLDYLR 262 VY DVD + AAE SV AQL YLR Sbjct 241 VYHDVDVSVRRAAEHSVAAQLGYLR 265 Lambda K H 0.318 0.137 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 397943428394 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40