BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3704c Length=432 Score E Sequences producing significant alignments: (Bits) Value gi|15610840|ref|NP_218221.1| glutamate--cysteine ligase gshA (ga... 859 0.0 gi|306778061|ref|ZP_07416398.1| glutamate-cysteine ligase gshA [... 858 0.0 gi|289572354|ref|ZP_06452581.1| glutamate-cysteine ligase gshA [... 858 0.0 gi|148824908|ref|YP_001289662.1| glutamate-cysteine ligase gshA ... 858 0.0 gi|340628677|ref|YP_004747129.1| glutamate--cysteine ligase GSHA... 850 0.0 gi|183985184|ref|YP_001853475.1| glutamate--cysteine ligase GshA... 615 3e-174 gi|240172814|ref|ZP_04751473.1| glutamate--cysteine ligase GshA ... 598 7e-169 gi|289763883|ref|ZP_06523261.1| glutamate-cysteine ligase gshA [... 597 1e-168 gi|41406404|ref|NP_959240.1| GshA [Mycobacterium avium subsp. pa... 595 7e-168 gi|118464049|ref|YP_879684.1| glutamate--cysteine ligase [Mycoba... 595 7e-168 gi|342861932|ref|ZP_08718576.1| glutamate--cysteine ligase [Myco... 575 6e-162 gi|254821106|ref|ZP_05226107.1| putative glutamate--cysteine lig... 567 1e-159 gi|289759861|ref|ZP_06519239.1| glutamate-cysteine ligase gshA [... 567 1e-159 gi|296166794|ref|ZP_06849213.1| probable glutamate--cysteine lig... 555 4e-156 gi|118472232|ref|YP_890469.1| glutamate--cysteine ligase [Mycoba... 522 6e-146 gi|120406432|ref|YP_956261.1| glutamate--cysteine ligase, GCS2 [... 520 2e-145 gi|108801845|ref|YP_642042.1| glutamate--cysteine ligase, GCS2 [... 518 6e-145 gi|289748220|ref|ZP_06507598.1| glutamate-cysteine ligase gshA [... 499 3e-139 gi|315446357|ref|YP_004079236.1| glutamate--cysteine ligase fami... 499 4e-139 gi|333992624|ref|YP_004525238.1| glutamate--cysteine ligase [Myc... 499 5e-139 gi|145221907|ref|YP_001132585.1| glutamate--cysteine ligase, GCS... 498 7e-139 gi|254773404|ref|ZP_05214920.1| putative glutamate--cysteine lig... 484 9e-135 gi|169627473|ref|YP_001701122.1| glutamate--cysteine ligase GshA... 372 6e-101 gi|289748219|ref|ZP_06507597.1| glutamate-cysteine ligase gshA [... 355 7e-96 gi|284988828|ref|YP_003407382.1| glutamate/cysteine ligase famil... 340 2e-91 gi|269127843|ref|YP_003301213.1| glutamate/cysteine ligase famil... 264 2e-68 gi|336180295|ref|YP_004585670.1| glutamate/cysteine ligase famil... 262 1e-67 gi|312200432|ref|YP_004020493.1| glutamate/cysteine ligase famil... 261 2e-67 gi|86743186|ref|YP_483586.1| glutamate--cysteine ligase, GCS2 [F... 244 2e-62 gi|288921440|ref|ZP_06415718.1| glutamate/cysteine ligase family... 238 1e-60 gi|158319017|ref|YP_001511525.1| glutamate--cysteine ligase GCS2... 236 4e-60 gi|111226173|ref|YP_716967.1| glutamate--cysteine ligase GSHA [F... 228 1e-57 gi|297559615|ref|YP_003678589.1| glutamate/cysteine ligase famil... 218 1e-54 gi|302562250|ref|ZP_07314592.1| glutamate-cysteine ligase [Strep... 213 8e-53 gi|345003686|ref|YP_004806540.1| glutamate/cysteine ligase famil... 212 1e-52 gi|271961911|ref|YP_003336107.1| glutamate/cysteine ligase [Stre... 211 1e-52 gi|291435603|ref|ZP_06574993.1| conserved hypothetical protein [... 211 1e-52 gi|325002083|ref|ZP_08123195.1| glutamate--cysteine ligase GCS2 ... 207 3e-51 gi|256376253|ref|YP_003099913.1| glutamate--cysteine ligase GCS2... 207 3e-51 gi|315505720|ref|YP_004084607.1| glutamate/cysteine ligase famil... 204 3e-50 gi|345011675|ref|YP_004814029.1| glutamate/cysteine ligase famil... 204 3e-50 gi|302867878|ref|YP_003836515.1| glutamate/cysteine ligase famil... 202 8e-50 gi|302555740|ref|ZP_07308082.1| glutamate-cysteine ligase [Strep... 202 8e-50 gi|117165100|emb|CAJ88654.1| putative glutamate-cysteine ligase ... 202 8e-50 gi|297204104|ref|ZP_06921501.1| glutamate-cysteine ligase [Strep... 202 1e-49 gi|291449352|ref|ZP_06588742.1| glutamate-cysteine ligase [Strep... 202 1e-49 gi|294632553|ref|ZP_06711113.1| glutamate-cysteine ligase [Strep... 202 1e-49 gi|239992362|ref|ZP_04713026.1| putative glutamylcysteine synthe... 201 1e-49 gi|329938527|ref|ZP_08287952.1| Glutamate-cysteine ligase [Strep... 201 2e-49 gi|302548228|ref|ZP_07300570.1| glutamate-cysteine ligase [Strep... 201 2e-49 >gi|15610840|ref|NP_218221.1| glutamate--cysteine ligase gshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) [Mycobacterium tuberculosis H37Rv] gi|15843323|ref|NP_338360.1| glutamate--cysteine ligase, putative [Mycobacterium tuberculosis CDC1551] gi|31794875|ref|NP_857368.1| glutamate--cysteine ligase gshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) [Mycobacterium bovis AF2122/97] 60 more sequence titles Length=432 Score = 859 bits (2219), Expect = 0.0, Method: Compositional matrix adjust. Identities = 432/432 (100%), Positives = 432/432 (100%), Gaps = 0/432 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP Sbjct 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA Sbjct 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA Sbjct 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS Sbjct 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH Sbjct 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT Sbjct 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI Sbjct 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 Query 421 ASAVTGMMHGAS 432 ASAVTGMMHGAS Sbjct 421 ASAVTGMMHGAS 432 >gi|306778061|ref|ZP_07416398.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis SUMu001] gi|306974178|ref|ZP_07486839.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis SUMu010] gi|307081886|ref|ZP_07491056.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis SUMu011] gi|308213590|gb|EFO72989.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis SUMu001] gi|308356450|gb|EFP45301.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis SUMu010] gi|308360397|gb|EFP49248.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis SUMu011] Length=432 Score = 858 bits (2218), Expect = 0.0, Method: Compositional matrix adjust. Identities = 431/432 (99%), Positives = 432/432 (100%), Gaps = 0/432 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP Sbjct 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA Sbjct 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA Sbjct 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS Sbjct 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH Sbjct 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVAT+WDT Sbjct 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATSWDT 360 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI Sbjct 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 Query 421 ASAVTGMMHGAS 432 ASAVTGMMHGAS Sbjct 421 ASAVTGMMHGAS 432 >gi|289572354|ref|ZP_06452581.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis K85] gi|339633695|ref|YP_004725337.1| glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) [Mycobacterium africanum GM041182] gi|289536785|gb|EFD41363.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis K85] gi|339333051|emb|CCC28781.1| glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) [Mycobacterium africanum GM041182] Length=432 Score = 858 bits (2218), Expect = 0.0, Method: Compositional matrix adjust. Identities = 431/432 (99%), Positives = 432/432 (100%), Gaps = 0/432 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MTLAAMTA+ASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP Sbjct 1 MTLAAMTASASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA Sbjct 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA Sbjct 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS Sbjct 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH Sbjct 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT Sbjct 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI Sbjct 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 Query 421 ASAVTGMMHGAS 432 ASAVTGMMHGAS Sbjct 421 ASAVTGMMHGAS 432 >gi|148824908|ref|YP_001289662.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis F11] gi|148723435|gb|ABR08060.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis F11] Length=432 Score = 858 bits (2217), Expect = 0.0, Method: Compositional matrix adjust. Identities = 431/432 (99%), Positives = 431/432 (99%), Gaps = 0/432 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP Sbjct 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA Sbjct 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA Sbjct 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDS RCGPILGAS Sbjct 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSTRCGPILGAS 240 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH Sbjct 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT Sbjct 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI Sbjct 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 Query 421 ASAVTGMMHGAS 432 ASAVTGMMHGAS Sbjct 421 ASAVTGMMHGAS 432 >gi|340628677|ref|YP_004747129.1| glutamate--cysteine ligase GSHA [Mycobacterium canettii CIPT 140010059] gi|340006867|emb|CCC46056.1| glutamate--cysteine ligase GSHA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) [Mycobacterium canettii CIPT 140010059] Length=432 Score = 850 bits (2197), Expect = 0.0, Method: Compositional matrix adjust. Identities = 428/432 (99%), Positives = 429/432 (99%), Gaps = 0/432 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP Sbjct 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA Sbjct 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 LANAGLGLV LGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA Sbjct 121 LANAGLGLVSLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS Sbjct 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 GDHPGIDWAKYALKAPVMMVRSPD QDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH Sbjct 241 GDHPGIDWAKYALKAPVMMVRSPDAQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT Sbjct 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AARIGLADRRLYLAANRCLAIAARRVPTELI AMQRLVDHVDRGVCPADDFSDRVIAGGI Sbjct 361 AARIGLADRRLYLAANRCLAIAARRVPTELIDAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 Query 421 ASAVTGMMHGAS 432 ASA+TGMMHGAS Sbjct 421 ASAITGMMHGAS 432 >gi|183985184|ref|YP_001853475.1| glutamate--cysteine ligase GshA [Mycobacterium marinum M] gi|183178510|gb|ACC43620.1| glutamate--cysteine ligase GshA [Mycobacterium marinum M] Length=429 Score = 615 bits (1587), Expect = 3e-174, Method: Compositional matrix adjust. Identities = 312/430 (73%), Positives = 349/430 (82%), Gaps = 3/430 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MT A AA SQLD++ D +I S+ AA+YIA+GCLVDGP+GRVGLE+EAHC+DPADP Sbjct 1 MTFAPSPAATSQLDSSRAADADIAGSAVAAQYIANGCLVDGPIGRVGLEIEAHCYDPADP 60 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 RRPSWEEI +VLE L PGGS V+VEPGGAVELSGPP DG+LAAI AM RDQAVLRSA Sbjct 61 HRRPSWEEIGDVLEGLGKPPGGSAVTVEPGGAVELSGPPCDGILAAIDAMHRDQAVLRSA 120 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 A+AGLGLV LGADP+R +R+NPGARY+AMEQFF AS SG+ GAAMMTSTA+IQVNLDA Sbjct 121 FADAGLGLVCLGADPIRPTMRINPGARYQAMEQFFTASQSGMAGAAMMTSTASIQVNLDA 180 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQ GWA RVRLAHALGPTMIAIAANSPMLGG FSGW+STRQRVWGQMD RCGPILGAS Sbjct 181 GPQSGWASRVRLAHALGPTMIAIAANSPMLGGEFSGWRSTRQRVWGQMDDGRCGPILGAS 240 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 D P DWA YALKAPVM+V +PD AVT +VPF DWVDGRVLL RR T ADL YH Sbjct 241 ADDPATDWAHYALKAPVMLVHNPDAV---AVTHHVPFADWVDGRVLLGDRRPTYADLDYH 297 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPRQWLEIRYLDS+ D WPAVVFTLVTLLDDP AA+LA +AV+PVAT WDT Sbjct 298 LTTLFPPVRPRQWLEIRYLDSLSDVFWPAVVFTLVTLLDDPGAAELAFEAVQPVATEWDT 357 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AAR GL D RL+ AA+RC+AIAA R P EL A+Q L+ +V RG CP DDF D+V G+ Sbjct 358 AARAGLGDPRLHAAASRCVAIAAERAPAELADALQSLLAYVQRGRCPGDDFGDQVTEHGV 417 Query 421 ASAVTGMMHG 430 A A+ + G Sbjct 418 APAIARLARG 427 >gi|240172814|ref|ZP_04751473.1| glutamate--cysteine ligase GshA [Mycobacterium kansasii ATCC 12478] Length=429 Score = 598 bits (1541), Expect = 7e-169, Method: Compositional matrix adjust. Identities = 320/430 (75%), Positives = 355/430 (83%), Gaps = 3/430 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MT A TAAA+QLD+A D EI AA EY+AD CLVDGPLGRVGLE+EAHC+DPADP Sbjct 1 MTFAPSTAAAAQLDSAGDGDSEIASLEAAGEYVADSCLVDGPLGRVGLELEAHCYDPADP 60 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 FRRP W+EIT+VL+W+SPLPGGS VSVEPGGAVELSGPP DGV+AAI AM RDQAVLR A Sbjct 61 FRRPGWDEITDVLDWVSPLPGGSAVSVEPGGAVELSGPPCDGVVAAIDAMNRDQAVLRPA 120 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 A+AGLGLVFLGADPLR R+NPG RYRAMEQFFAAS SG GAAMMT+TA+IQVN+DA Sbjct 121 FADAGLGLVFLGADPLRPTKRINPGPRYRAMEQFFAASDSGAAGAAMMTATASIQVNVDA 180 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQ WA RVRLAHALGPTMIAIAANSPMLGG FSGW+STRQRVWGQMD+ARCGPILGAS Sbjct 181 GPQADWASRVRLAHALGPTMIAIAANSPMLGGEFSGWRSTRQRVWGQMDAARCGPILGAS 240 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 GD P DWA+YALKAPVM+V +PD AVT YVPF DW DG VLL RR T ADL YH Sbjct 241 GDEPATDWARYALKAPVMLVHNPDAV---AVTHYVPFADWADGTVLLGDRRPTTADLDYH 297 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPRQWLEIRYLDSVPD WPA+ F +VTLLDDP AA+LA +AVEPVATAWDT Sbjct 298 LTTLFPPVRPRQWLEIRYLDSVPDTFWPALAFMVVTLLDDPAAAELAAEAVEPVATAWDT 357 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AAR+GL DRRLY AANRC+ +AA R PT + AMQ L+ +V++G C DDF+DRV+ GI Sbjct 358 AARVGLEDRRLYAAANRCVTVAAERAPTRIADAMQVLIANVEQGRCCGDDFADRVVESGI 417 Query 421 ASAVTGMMHG 430 A AV + G Sbjct 418 APAVARLARG 427 >gi|289763883|ref|ZP_06523261.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis GM 1503] gi|289711389|gb|EFD75405.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis GM 1503] Length=311 Score = 597 bits (1540), Expect = 1e-168, Method: Compositional matrix adjust. Identities = 299/301 (99%), Positives = 299/301 (99%), Gaps = 0/301 (0%) Query 132 GADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVR 191 G PLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVR Sbjct 11 GCRPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVR 70 Query 192 LAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKY 251 LAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKY Sbjct 71 LAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKY 130 Query 252 ALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPR 311 ALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPR Sbjct 131 ALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPR 190 Query 312 QWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRL 371 QWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRL Sbjct 191 QWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRL 250 Query 372 YLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGA 431 YLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGA Sbjct 251 YLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGA 310 Query 432 S 432 S Sbjct 311 S 311 >gi|41406404|ref|NP_959240.1| GshA [Mycobacterium avium subsp. paratuberculosis K-10] gi|41394753|gb|AAS02623.1| GshA [Mycobacterium avium subsp. paratuberculosis K-10] gi|336460880|gb|EGO39765.1| glutamate--cysteine ligase family protein [Mycobacterium avium subsp. paratuberculosis S397] Length=436 Score = 595 bits (1533), Expect = 7e-168, Method: Compositional matrix adjust. Identities = 319/434 (74%), Positives = 352/434 (82%), Gaps = 7/434 (1%) Query 1 MTLAAMTAAASQLDNAAPDD----VEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFD 56 MT A TAAAS+ P E+TDS+A A+YIA GCL D PLGRVGLE+EAHC D Sbjct 1 MTFAPSTAAASRPAGGDPAAELRIAELTDSAAVAQYIARGCLADAPLGRVGLEVEAHCHD 60 Query 57 PADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAV 116 P DP RRP W+EI VL+ L LPGGS V+VEPGGAVELSGPPADGVLAAI AM RDQAV Sbjct 61 PQDPCRRPGWDEIAAVLDALPALPGGSRVTVEPGGAVELSGPPADGVLAAIDAMRRDQAV 120 Query 117 LRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQV 176 LR A A AGLGLVFLGADPLR P R+NPGARYRAME+FFA S SG GAAMMTSTA+IQV Sbjct 121 LRPAFAGAGLGLVFLGADPLRPPQRINPGARYRAMERFFATSRSGEAGAAMMTSTASIQV 180 Query 177 NLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPI 236 N+DAGP+EGWA RVRLAHALGPTMIA+ ANSPML G F+GW S+RQRVWG+MDSARCGP+ Sbjct 181 NVDAGPREGWAARVRLAHALGPTMIAMTANSPMLDGDFTGWVSSRQRVWGRMDSARCGPV 240 Query 237 LGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVAD 296 LGASGD PG DWA+YALKAPVM+V +PD + AVT +VPF DWVDGRVLL GRR TVAD Sbjct 241 LGASGDDPGTDWARYALKAPVMLVHTPDAE---AVTRWVPFADWVDGRVLLGGRRPTVAD 297 Query 297 LVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVAT 356 L YHLTTLFPPVRPRQWLEIRYLDSVPD +WPAVVFTLV LLDDPVAA LA AVEPVAT Sbjct 298 LEYHLTTLFPPVRPRQWLEIRYLDSVPDTLWPAVVFTLVALLDDPVAAGLAARAVEPVAT 357 Query 357 AWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVI 416 AWD AAR+GL DRRLY AAN CLAIAA R P EL M+RLV V++G CP DDF+D+VI Sbjct 358 AWDVAARVGLRDRRLYAAANACLAIAAERAPAELAEPMRRLVRLVEQGRCPGDDFADQVI 417 Query 417 AGGIASAVTGMMHG 430 GIA++V+ G Sbjct 418 EHGIAASVSRAARG 431 >gi|118464049|ref|YP_879684.1| glutamate--cysteine ligase [Mycobacterium avium 104] gi|118165336|gb|ABK66233.1| putative glutamate--cysteine ligase [Mycobacterium avium 104] Length=436 Score = 595 bits (1533), Expect = 7e-168, Method: Compositional matrix adjust. Identities = 320/434 (74%), Positives = 351/434 (81%), Gaps = 7/434 (1%) Query 1 MTLAAMTAAASQLDNAAPDD----VEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFD 56 MT A TAAAS+ P E+TDS+A A YIA GCL D PLGRVGLE+EAHC D Sbjct 1 MTFAPSTAAASRPAGGDPAAELRIAELTDSAAVAHYIARGCLADAPLGRVGLEVEAHCHD 60 Query 57 PADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAV 116 P DP RRP W+EI VL+ L LPGGS V+VEPGGAVELSGPPADGVLAAI AM RDQAV Sbjct 61 PQDPCRRPGWDEIAAVLDALPALPGGSRVTVEPGGAVELSGPPADGVLAAIDAMRRDQAV 120 Query 117 LRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQV 176 LR A A AGLGLVFLGADPLR P R+NPGARYRAME+FFA S SG GAAMMTSTA+IQV Sbjct 121 LRPAFAEAGLGLVFLGADPLRPPQRINPGARYRAMERFFATSRSGEAGAAMMTSTASIQV 180 Query 177 NLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPI 236 N+DAGP+EGWA RVRLAHALGPTMIA+ ANSPML G F+GW S+RQRVWG+MDSARCGPI Sbjct 181 NVDAGPREGWAARVRLAHALGPTMIAMTANSPMLDGDFTGWVSSRQRVWGRMDSARCGPI 240 Query 237 LGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVAD 296 LGASGD PG DWA+YALKAPVM+V +PD + AVT +VPF DWVDGRVLL GRR TVAD Sbjct 241 LGASGDDPGTDWARYALKAPVMLVHTPDAE---AVTRWVPFADWVDGRVLLGGRRPTVAD 297 Query 297 LVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVAT 356 L YHLTTLFPPVRPRQWLEIRYLDSVPD +WPAVVFTLV LLDDPVAA LA AVEPVAT Sbjct 298 LEYHLTTLFPPVRPRQWLEIRYLDSVPDTLWPAVVFTLVALLDDPVAAGLAARAVEPVAT 357 Query 357 AWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVI 416 AWD AAR+GL DRRLY AAN CLAIAA R P EL M+RLV V++G CP DDF+D+VI Sbjct 358 AWDVAARVGLRDRRLYAAANACLAIAAERAPAELAEPMRRLVRLVEQGRCPGDDFADQVI 417 Query 417 AGGIASAVTGMMHG 430 GIA++V+ G Sbjct 418 EHGIAASVSRAARG 431 >gi|342861932|ref|ZP_08718576.1| glutamate--cysteine ligase [Mycobacterium colombiense CECT 3035] gi|342130472|gb|EGT83781.1| glutamate--cysteine ligase [Mycobacterium colombiense CECT 3035] Length=440 Score = 575 bits (1482), Expect = 6e-162, Method: Compositional matrix adjust. Identities = 319/433 (74%), Positives = 357/433 (83%), Gaps = 11/433 (2%) Query 1 MTLAAMTAAASQLD------NAAP--DDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEA 52 MT A +TAAASQ + + AP D E+ DS+A A YIA+GCLVD PLGRVGLE+EA Sbjct 1 MTFAPITAAASQSESRVAGADPAPELDIAELGDSAAVAHYIAEGCLVDAPLGRVGLELEA 60 Query 53 HCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTR 112 HC DPADP RRPSW EI++VL+ L LPGGS ++VEPGGAVELSGPPADGVL AI AM R Sbjct 61 HCHDPADPHRRPSWSEISDVLDALPALPGGSRITVEPGGAVELSGPPADGVLPAIDAMRR 120 Query 113 DQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTA 172 DQAVLR A A AGLGLVFLGADPLR P R+NPGARYRAMEQFFA S SG GAAMMTSTA Sbjct 121 DQAVLRPAFAAAGLGLVFLGADPLRPPKRINPGARYRAMEQFFATSRSGEAGAAMMTSTA 180 Query 173 AIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSAR 232 +IQVNLDAGP++GWA RVRLAHALGPTMIAI ANSPML G F+GW S+RQRVWG+MDSAR Sbjct 181 SIQVNLDAGPRDGWAARVRLAHALGPTMIAITANSPMLDGDFTGWVSSRQRVWGRMDSAR 240 Query 233 CGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRA 292 CGPILGASGD PG DW +YALKAPVM+V +PD + AVT +VPF DWVDGRVLL RR Sbjct 241 CGPILGASGDDPGTDWGRYALKAPVMLVHNPDAE---AVTQWVPFADWVDGRVLLGDRRP 297 Query 293 TVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVE 352 +VADL YHLTTLFPPVRPRQWLEIRYLDSVPD +WPAV FTL LLDDP AAD+A +AVE Sbjct 298 SVADLEYHLTTLFPPVRPRQWLEIRYLDSVPDALWPAVAFTLAVLLDDPDAADIAAEAVE 357 Query 353 PVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFS 412 PVATAWDTAAR+GL DRRLY AAN C+A+AA + P EL +MQRLV VD+G CP DDFS Sbjct 358 PVATAWDTAARVGLRDRRLYAAANACMAVAAAKAPAELADSMQRLVRLVDQGRCPGDDFS 417 Query 413 DRVIAGGIASAVT 425 DRV+ G+A+AV+ Sbjct 418 DRVVEHGLAAAVS 430 >gi|254821106|ref|ZP_05226107.1| putative glutamate--cysteine ligase [Mycobacterium intracellulare ATCC 13950] Length=433 Score = 567 bits (1462), Expect = 1e-159, Method: Compositional matrix adjust. Identities = 315/434 (73%), Positives = 351/434 (81%), Gaps = 7/434 (1%) Query 1 MTLAAMTAAASQLDNAAP----DDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFD 56 MT A +TAAA + A P E+TDS+A A+YIADGCLVD PLGRVGLE+EAHC D Sbjct 1 MTFAPITAAAPRSTGADPAPELKIAELTDSTAVAQYIADGCLVDAPLGRVGLELEAHCHD 60 Query 57 PADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAV 116 PA P RRP W+EI VL+ L LPGGS ++VEPGGAVELSGPPADGVL AI AM RDQAV Sbjct 61 PAAPHRRPGWDEIAAVLDGLPALPGGSRITVEPGGAVELSGPPADGVLPAIEAMRRDQAV 120 Query 117 LRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQV 176 L+ A A AGLGLVFLGADPLR P R+NPGARYRAME+FFA S SG GAAMMTSTA+IQV Sbjct 121 LQPAFAEAGLGLVFLGADPLRPPQRINPGARYRAMERFFATSRSGEAGAAMMTSTASIQV 180 Query 177 NLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPI 236 N+DAGP+EGWA RVRLAHALGPTMIAI ANSPMLGG F+GW S+RQRVWGQMDSARCGPI Sbjct 181 NVDAGPREGWAARVRLAHALGPTMIAITANSPMLGGDFTGWVSSRQRVWGQMDSARCGPI 240 Query 237 LGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVAD 296 LGASGD PG DW +YALKAPVM+V +P + AVT +VPF DWVDGRVLL RR ++AD Sbjct 241 LGASGDDPGTDWGRYALKAPVMLVHTPGAE---AVTQWVPFADWVDGRVLLGDRRPSIAD 297 Query 297 LVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVAT 356 L YHLTTLFPPVRPRQWLEIRYLDSVPD +WPAVVFTLV LLDDP AAD A +AV PVAT Sbjct 298 LEYHLTTLFPPVRPRQWLEIRYLDSVPDALWPAVVFTLVALLDDPTAADAAAEAVAPVAT 357 Query 357 AWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVI 416 AWD AAR+GL DRRLY AAN C+AIAA R P E+ AMQRLVD V++G CP DDF+DRVI Sbjct 358 AWDIAARLGLRDRRLYAAANACVAIAAERAPAEVGDAMQRLVDLVEQGRCPGDDFADRVI 417 Query 417 AGGIASAVTGMMHG 430 G+ + V+ G Sbjct 418 EHGVTAEVSRAARG 431 >gi|289759861|ref|ZP_06519239.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis T85] gi|289715425|gb|EFD79437.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis T85] Length=282 Score = 567 bits (1461), Expect = 1e-159, Method: Compositional matrix adjust. Identities = 282/282 (100%), Positives = 282/282 (100%), Gaps = 0/282 (0%) Query 151 MEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPML 210 MEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPML Sbjct 1 MEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPML 60 Query 211 GGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRA 270 GGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRA Sbjct 61 GGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRA 120 Query 271 VTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAV 330 VTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAV Sbjct 121 VTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAV 180 Query 331 VFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTEL 390 VFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTEL Sbjct 181 VFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTEL 240 Query 391 IGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS 432 IGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS Sbjct 241 IGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS 282 >gi|296166794|ref|ZP_06849213.1| probable glutamate--cysteine ligase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295897843|gb|EFG77430.1| probable glutamate--cysteine ligase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=363 Score = 555 bits (1431), Expect = 4e-156, Method: Compositional matrix adjust. Identities = 285/371 (77%), Positives = 313/371 (85%), Gaps = 8/371 (2%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MT AA+T A ++L ++ E+ DS AAA YIADGCLVD PLGRVGLE+EAHC DP DP Sbjct 1 MTFAAITTAGTELGSS-----EMADSQAAAGYIADGCLVDSPLGRVGLELEAHCHDPVDP 55 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 RRP W+EI VL L LPGGS ++VEPGGAVELSGPPADGVLAAI AM RDQAVLRSA Sbjct 56 HRRPGWDEIAGVLGSLPELPGGSRITVEPGGAVELSGPPADGVLAAIDAMRRDQAVLRSA 115 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 +AGLGLVFLGADPLR P R+NPGARYRAMEQFFA+S SG GAAMMTSTA+IQVNLDA Sbjct 116 FVDAGLGLVFLGADPLRPPKRINPGARYRAMEQFFASSRSGEAGAAMMTSTASIQVNLDA 175 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GP+ GWA+RVRLAHALGPTMIA+AANSPML G F+GW STRQ VWGQMDSARCGP+LG S Sbjct 176 GPRAGWADRVRLAHALGPTMIAMAANSPMLCGGFTGWSSTRQWVWGQMDSARCGPVLGVS 235 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 GD PG DWA+YALKAPVM+V PD AVTD+VPF DWVDGRVLL GRR TVADL YH Sbjct 236 GDDPGTDWARYALKAPVMLVHCPDAV---AVTDWVPFADWVDGRVLLGGRRPTVADLEYH 292 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPR+WLEIRYLDSVP++ WPA+VFTLV LLDDPVAA +A +AVEPVATAWDT Sbjct 293 LTTLFPPVRPRRWLEIRYLDSVPEDFWPALVFTLVALLDDPVAAGIAAEAVEPVATAWDT 352 Query 361 AARIGLADRRL 371 AAR GL DRRL Sbjct 353 AARSGLRDRRL 363 >gi|118472232|ref|YP_890469.1| glutamate--cysteine ligase [Mycobacterium smegmatis str. MC2 155] gi|118173519|gb|ABK74415.1| glutamate--cysteine ligase [Mycobacterium smegmatis str. MC2 155] Length=423 Score = 522 bits (1344), Expect = 6e-146, Method: Compositional matrix adjust. Identities = 271/410 (67%), Positives = 319/410 (78%), Gaps = 3/410 (0%) Query 21 VEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLP 80 VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+E++ V+ + PLP Sbjct 15 VEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLP 74 Query 81 GGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPV 140 GGS ++VEPGGAVELSGPP DG LAA+ A+ D+AVLR+ A LGLV LG DPLR Sbjct 75 GGSRITVEPGGAVELSGPPYDGPLAAVAALQADRAVLRAEFARRNLGLVLLGTDPLRPTR 134 Query 141 RVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTM 200 RVNPGARY AMEQFF AS + GAAMMT+TA++QVNLDAGP++GWAERVRLAHALGPTM Sbjct 135 RVNPGARYSAMEQFFTASGTAEAGAAMMTATASVQVNLDAGPRDGWAERVRLAHALGPTM 194 Query 201 IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMV 260 IAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P +WA+YAL+APVM+V Sbjct 195 IAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEWARYALRAPVMLV 254 Query 261 RSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLD 320 SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPPVRPR+WLEIRYLD Sbjct 255 NSPDAV---PVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLD 311 Query 321 SVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLA 380 SVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL DR L+ AA C+ Sbjct 312 SVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVR 371 Query 381 IAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHG 430 +AA R P EL +M L+ V + PADDFSDRV+A GIA+AV + G Sbjct 372 LAAERAPAELEESMTLLMRSVQQRRSPADDFSDRVVARGIAAAVRELAKG 421 >gi|120406432|ref|YP_956261.1| glutamate--cysteine ligase, GCS2 [Mycobacterium vanbaalenii PYR-1] gi|119959250|gb|ABM16255.1| glutamate--cysteine ligase, GCS2 [Mycobacterium vanbaalenii PYR-1] Length=424 Score = 520 bits (1339), Expect = 2e-145, Method: Compositional matrix adjust. Identities = 276/408 (68%), Positives = 322/408 (79%), Gaps = 3/408 (0%) Query 23 ITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGG 82 ++ + AAA++I DGCL+DGP+G+VGLE+EAHCFD DP RRP W+E+T + L PLPGG Sbjct 18 LSSAEAAAQHIVDGCLIDGPVGQVGLEVEAHCFDLTDPSRRPGWDELTATITALPPLPGG 77 Query 83 SVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRV 142 SVV+VEPGGAVELSGPP +AI AM D VLR+A A AGLGLV +GADPLR RV Sbjct 78 SVVTVEPGGAVELSGPPLAEPASAISAMAADHTVLRAAFARAGLGLVLVGADPLRPAARV 137 Query 143 NPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIA 202 NPG RY+AME FF AS SG GAAMMTSTA++QVNL+AGP+ GWA+RVRLAHALGPTMIA Sbjct 138 NPGPRYQAMEAFFRASDSGDAGAAMMTSTASVQVNLEAGPRAGWADRVRLAHALGPTMIA 197 Query 203 IAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRS 262 IAANSP+LGG F+GWQSTRQ VW ++DSARCGPILGASGD P DWA+YAL+APVM+V S Sbjct 198 IAANSPVLGGDFTGWQSTRQLVWSRLDSARCGPILGASGDDPASDWARYALRAPVMLVHS 257 Query 263 PDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSV 322 PD VT +VPF DW DGRVLLD R T+ADL YHLTTLFPPVRPR +LE+RYLDSV Sbjct 258 PDPT---PVTQWVPFADWADGRVLLDDRPPTLADLDYHLTTLFPPVRPRGFLEVRYLDSV 314 Query 323 PDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIA 382 PD WPAVV+TL TLLDDP AAD+A +A E VATAWD AA++GL DRRL+ AA RC+ A Sbjct 315 PDATWPAVVYTLATLLDDPAAADVAAEATEEVATAWDRAAQLGLRDRRLHAAATRCVQAA 374 Query 383 ARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHG 430 A R P L +M LV V++G PADDF+DRV+A GIA AVT + G Sbjct 375 ADRAPRALEESMGHLVRSVEQGRSPADDFADRVVAHGIADAVTELAQG 422 >gi|108801845|ref|YP_642042.1| glutamate--cysteine ligase, GCS2 [Mycobacterium sp. MCS] gi|119870998|ref|YP_940950.1| glutamate--cysteine ligase, GCS2 [Mycobacterium sp. KMS] gi|126437813|ref|YP_001073504.1| glutamate--cysteine ligase, GCS2 [Mycobacterium sp. JLS] gi|108772264|gb|ABG10986.1| glutamate--cysteine ligase, GCS2 [Mycobacterium sp. MCS] gi|119697087|gb|ABL94160.1| glutamate--cysteine ligase, GCS2 [Mycobacterium sp. KMS] gi|126237613|gb|ABO01014.1| glutamate--cysteine ligase, GCS2 [Mycobacterium sp. JLS] Length=424 Score = 518 bits (1335), Expect = 6e-145, Method: Compositional matrix adjust. Identities = 272/418 (66%), Positives = 324/418 (78%), Gaps = 5/418 (1%) Query 15 NAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLE 74 + APD E ++ AAE+I + CL DGP+G+VGLE+EAH FD ADP RRP W E+T+ + Sbjct 12 DTAPD--EFASAADAAEHITEHCLHDGPVGQVGLEVEAHSFDLADPRRRPDWGEVTDAIA 69 Query 75 WLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGAD 134 + LPGGS ++VEPGGAVELSGPPADG +AAI AMT D+AVLR+A A GLGLV +GAD Sbjct 70 GVGALPGGSRITVEPGGAVELSGPPADGSVAAIAAMTSDRAVLRTAFAQRGLGLVLVGAD 129 Query 135 PLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAH 194 PLR P RVNPG RY AME FF AS +G GA MMTSTA+IQ+NLDAGP+ GWA+RVRLAH Sbjct 130 PLRRPRRVNPGGRYSAMEAFFTASGTGAAGAFMMTSTASIQLNLDAGPRRGWADRVRLAH 189 Query 195 ALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALK 254 ALGPTMIA ANSP+L GRFSGWQS+RQ VWG++D ARCGP+LGASGD P DWA+YAL+ Sbjct 190 ALGPTMIAATANSPLLAGRFSGWQSSRQWVWGELDEARCGPVLGASGDDPASDWARYALR 249 Query 255 APVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWL 314 APVM+V +P+ VTD+VPF +W DG+ LL GRR T +DL YHLTTLFPPVRPR+WL Sbjct 250 APVMLVHNPEPV---PVTDWVPFAEWADGQTLLGGRRPTRSDLEYHLTTLFPPVRPRRWL 306 Query 315 EIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLA 374 EIRYLD+V D +WPAV FTL TLLDDP AAD+A +A E VATAWD AARIGL DRRL+ A Sbjct 307 EIRYLDAVSDALWPAVAFTLTTLLDDPAAADIAAEATESVATAWDRAARIGLGDRRLHAA 366 Query 375 ANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS 432 A RC+ AA R P ++ +MQ+LV V+ G PADDF+DR +A GI AV + G S Sbjct 367 ALRCVETAAERAPAAVMESMQQLVRSVEEGRSPADDFADRAVAYGIGPAVRQLAKGES 424 >gi|289748220|ref|ZP_06507598.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis T92] gi|289688807|gb|EFD56236.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis T92] Length=259 Score = 499 bits (1286), Expect = 3e-139, Method: Compositional matrix adjust. Identities = 250/250 (100%), Positives = 250/250 (100%), Gaps = 0/250 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP Sbjct 10 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 69 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA Sbjct 70 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 129 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA Sbjct 130 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 189 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS Sbjct 190 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 249 Query 241 GDHPGIDWAK 250 GDHPGIDWAK Sbjct 250 GDHPGIDWAK 259 >gi|315446357|ref|YP_004079236.1| glutamate--cysteine ligase family protein [Mycobacterium sp. Spyr1] gi|315264660|gb|ADU01402.1| glutamate--cysteine ligase family protein [Mycobacterium sp. Spyr1] Length=424 Score = 499 bits (1285), Expect = 4e-139, Method: Compositional matrix adjust. Identities = 269/410 (66%), Positives = 320/410 (79%), Gaps = 3/410 (0%) Query 21 VEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLP 80 V +T + AA++I D CL D P G VGLE+EAHC+D +DPFRRP W+E+T V+ L LP Sbjct 16 VPLTSAEDAAQHIVDTCLKDVPPGPVGLEIEAHCYDLSDPFRRPGWDELTAVIADLPRLP 75 Query 81 GGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPV 140 GGS+V+VEPGGAVELSGPPA G A+ AM D+AVLR A AGLGLV LGADPLR Sbjct 76 GGSLVTVEPGGAVELSGPPATGTADAVSAMVTDRAVLRDVFAGAGLGLVLLGADPLRPAG 135 Query 141 RVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTM 200 RVNPG+RY AME+FFA S + GAAMMTSTA++QVNL+AG + GWA+RVRLAHALGPTM Sbjct 136 RVNPGSRYAAMERFFAESGTPEAGAAMMTSTASVQVNLEAGHRAGWADRVRLAHALGPTM 195 Query 201 IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMV 260 IAIAANSP+L G+F+GW STRQ VW Q+DSARCGPILG GD P DWA+YAL+APVM+V Sbjct 196 IAIAANSPVLAGKFTGWHSTRQLVWSQLDSARCGPILGVDGDDPASDWARYALRAPVMLV 255 Query 261 RSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLD 320 +P+ VT +VPF DW DGRVLLD RR T+ADL YHLTTLFPPVRPR +LE+RYLD Sbjct 256 HTPEAV---PVTQWVPFADWADGRVLLDDRRPTLADLDYHLTTLFPPVRPRGFLEVRYLD 312 Query 321 SVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLA 380 SVPD VWPAVVFTL TLLDDPVAAD+A +A EPVAT+WD AA++GL DRRL+ AA RC+ Sbjct 313 SVPDAVWPAVVFTLSTLLDDPVAADVAAEATEPVATSWDRAAQLGLDDRRLHTAAVRCVY 372 Query 381 IAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHG 430 AA R P L+ +M+ L V++G P DDF+DRV+ GIA+AVT + G Sbjct 373 AAADRAPAALVESMELLTRSVEQGRSPGDDFADRVVNDGIAAAVTRLAQG 422 >gi|333992624|ref|YP_004525238.1| glutamate--cysteine ligase [Mycobacterium sp. JDM601] gi|333488592|gb|AEF37984.1| glutamate--cysteine ligase GshA [Mycobacterium sp. JDM601] Length=428 Score = 499 bits (1284), Expect = 5e-139, Method: Compositional matrix adjust. Identities = 283/432 (66%), Positives = 323/432 (75%), Gaps = 4/432 (0%) Query 1 MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP 60 M LAA T S++D P + E++ S+ AAEYIAD CL DGP GRVGLE+EAHCFDPADP Sbjct 1 MALAAATQL-SRVDEPCPAETELSGSAEAAEYIADRCLTDGPPGRVGLEIEAHCFDPADP 59 Query 61 FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA 120 RRP W EI +VL+ L LPGGS V+VEPGGAVELS PP G AAI AM DQAVLR+A Sbjct 60 LRRPGWAEIGDVLQSLPGLPGGSRVTVEPGGAVELSSPPLAGAPAAIAAMAADQAVLRAA 119 Query 121 LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA 180 A AGLGLV LGADPLR R+NPG RY AMEQFFAASH+G GAAMMTSTA++Q+NLDA Sbjct 120 FAEAGLGLVALGADPLRPTQRINPGPRYAAMEQFFAASHTGSAGAAMMTSTASVQLNLDA 179 Query 181 GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS 240 G + WA+RVRLAHALGPTM+AIAANSP+L G FSGW+STRQRVW ++DS RCGP+LG Sbjct 180 GRRSRWADRVRLAHALGPTMVAIAANSPLLSGEFSGWRSTRQRVWSRLDSMRCGPVLGLD 239 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 G P DWA+YALKAPVM+V PD V+ YVPF DW DGRV L GRRA +ADL YH Sbjct 240 GTDPASDWARYALKAPVMLVHVPDAI---PVSRYVPFADWADGRVRLGGRRAAIADLDYH 296 Query 301 LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT 360 LTTLFPPVRPR WLEIRYLDSV D +WPA+VFTL TLLDDP AD A +AV PVATAWD Sbjct 297 LTTLFPPVRPRGWLEIRYLDSVGDALWPAIVFTLATLLDDPATADAAAEAVAPVATAWDV 356 Query 361 AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI 420 AARIGLAD RL+ AA RC+ + A R P L M RL + V+ CPADD +D V G+ Sbjct 357 AARIGLADPRLHAAARRCVGLVAGRAPASLRDGMDRLAEMVEWARCPADDVADEVARTGV 416 Query 421 ASAVTGMMHGAS 432 + V + G S Sbjct 417 TATVARLAGGRS 428 >gi|145221907|ref|YP_001132585.1| glutamate--cysteine ligase, GCS2 [Mycobacterium gilvum PYR-GCK] gi|145214393|gb|ABP43797.1| glutamate--cysteine ligase, GCS2 [Mycobacterium gilvum PYR-GCK] Length=448 Score = 498 bits (1282), Expect = 7e-139, Method: Compositional matrix adjust. Identities = 269/410 (66%), Positives = 320/410 (79%), Gaps = 3/410 (0%) Query 21 VEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLP 80 V +T + AA++I D CL D P G VGLE+EAHC+D +DPFRRP W+E+T V+ L LP Sbjct 40 VPLTSAEDAAQHIVDTCLKDVPPGPVGLEIEAHCYDLSDPFRRPGWDELTAVIADLPRLP 99 Query 81 GGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPV 140 GGS+V+VEPGGAVELSGPPA G A+ AM D+AVLR A AGLGLV LGADPLR Sbjct 100 GGSLVTVEPGGAVELSGPPATGTADAVSAMVTDRAVLRDVFAGAGLGLVLLGADPLRPAG 159 Query 141 RVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTM 200 RVNPG+RY AME+FFA S + GAAMMTSTA++QVNL+AG + GWA+RVRLAHALGPTM Sbjct 160 RVNPGSRYAAMERFFAESGTPEAGAAMMTSTASVQVNLEAGHRAGWADRVRLAHALGPTM 219 Query 201 IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMV 260 IAIAANSP+L G+F+GW STRQ VW Q+DSARCGPILG GD P DWA+YAL+APVM+V Sbjct 220 IAIAANSPVLAGKFTGWHSTRQLVWSQLDSARCGPILGVDGDDPASDWARYALRAPVMLV 279 Query 261 RSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLD 320 +P+ VT +VPF DW DGRVLLD RR T+ADL YHLTTLFPPVRPR +LE+RYLD Sbjct 280 HTPEAV---PVTQWVPFADWADGRVLLDDRRPTLADLDYHLTTLFPPVRPRGFLEVRYLD 336 Query 321 SVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLA 380 SVPD VWPAVVFTL TLLDDPVAAD+A +A EPVAT+WD AA++GL DRRL+ AA RC+ Sbjct 337 SVPDAVWPAVVFTLSTLLDDPVAADVAAEATEPVATSWDRAAQLGLDDRRLHTAAVRCVY 396 Query 381 IAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHG 430 AA R P L+ +M+ L V++G P DDF+DRV+ GIA+AVT + G Sbjct 397 AAADRAPAALVESMELLTRSVEQGRSPGDDFADRVVNDGIAAAVTRLAQG 446 >gi|254773404|ref|ZP_05214920.1| putative glutamate--cysteine ligase [Mycobacterium avium subsp. avium ATCC 25291] Length=337 Score = 484 bits (1247), Expect = 9e-135, Method: Compositional matrix adjust. Identities = 258/335 (78%), Positives = 282/335 (85%), Gaps = 3/335 (0%) Query 96 SGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFF 155 SGPPADGVLAAI AM RDQAVLR A A AGLGLVFLGADPLR P R+NPGARYRAME+FF Sbjct 1 SGPPADGVLAAIDAMRRDQAVLRPAFAEAGLGLVFLGADPLRPPQRINPGARYRAMERFF 60 Query 156 AASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFS 215 A S SG GAAMMTSTA+IQVN+DAGP+EGWA RVRLAHALGPTMIA+ ANSPML G F+ Sbjct 61 ATSRSGEAGAAMMTSTASIQVNVDAGPREGWAARVRLAHALGPTMIAMTANSPMLDGDFT 120 Query 216 GWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYV 275 GW S+RQRVWG+MDSARCGPILGASGD PG DWA+YALKAPVM+V +PD + AVT +V Sbjct 121 GWVSSRQRVWGRMDSARCGPILGASGDDPGTDWARYALKAPVMLVHTPDAE---AVTRWV 177 Query 276 PFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLV 335 PF DWVDGRVLL GRR TVADL YHLTTLFPPVRPRQWLEIRYLDSVPD +WPAVVFTLV Sbjct 178 PFADWVDGRVLLGGRRPTVADLEYHLTTLFPPVRPRQWLEIRYLDSVPDTLWPAVVFTLV 237 Query 336 TLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQ 395 LLDDPVAA LA AVEPVATAWD AAR+GL DRRLY AAN CLAIAA R P EL M+ Sbjct 238 ALLDDPVAAGLAARAVEPVATAWDVAARVGLRDRRLYAAANACLAIAAERAPAELAEPMR 297 Query 396 RLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHG 430 RLV V++G CP DDF+D+VI GIA++V+ G Sbjct 298 RLVRLVEQGRCPGDDFADQVIEHGIAASVSRAARG 332 >gi|169627473|ref|YP_001701122.1| glutamate--cysteine ligase GshA [Mycobacterium abscessus ATCC 19977] gi|169239440|emb|CAM60468.1| Glutamate--cysteine ligase GshA [Mycobacterium abscessus] Length=416 Score = 372 bits (955), Expect = 6e-101, Method: Compositional matrix adjust. Identities = 198/406 (49%), Positives = 256/406 (64%), Gaps = 4/406 (0%) Query 23 ITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGG 82 ++ AAE+IA D +G VGLE+E+H + P RR +W + EV + + LPG Sbjct 14 LSGHDEAAEHIARQAFADAQVGAVGLELESHTVELTAPHRRITWNRLREVGDSVPDLPGS 73 Query 83 SVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRV 142 S ++ EPGGAVELSGPP V +AI +M D +L + AG+ L LG DPLR P RV Sbjct 74 SAITFEPGGAVELSGPPCSDVWSAISSMRADHEILTAVYRGAGIALASLGTDPLRRPERV 133 Query 143 NPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIA 202 NPGARY AME+ F A+ G MMT TA++QVN+ +G W +R LA +GPTM A Sbjct 134 NPGARYVAMERHFGAAGYGETALQMMTCTASLQVNVQSGTPRQWRDRFVLAQRIGPTMAA 193 Query 203 IAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRS 262 ++A+SPML GR +G ++TRQ +W +D RC P+ G P W +YAL+APVM+VR+ Sbjct 194 LSASSPMLTGRPTGRRNTRQWIWDNLDPRRCAPV--EIGVDPTESWVEYALRAPVMLVRN 251 Query 263 PDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSV 322 D D AV VPF WVDG + L GR T DL YHLTTLFPPVRPR+WLE+RYLD+ Sbjct 252 KDGAD--AVVTRVPFQSWVDGTMPLAGRAPTTEDLDYHLTTLFPPVRPRRWLELRYLDAA 309 Query 323 PDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIA 382 PD WPA+ FT V LDDP AD+A + EPV AW AARIGL D L+ AA+R ++ A Sbjct 310 PDWWWPALAFTAVAALDDPQVADIAAEIAEPVGNAWGVAARIGLEDPALHAAAHRLVSAA 369 Query 383 ARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMM 428 P EL M+ L++ V++G CPADDF D V G+ A +G + Sbjct 370 CAVAPPELATDMEFLLERVEQGRCPADDFIDNVTEYGVEKAFSGAI 415 >gi|289748219|ref|ZP_06507597.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis T92] gi|289688806|gb|EFD56235.1| glutamate-cysteine ligase gshA [Mycobacterium tuberculosis T92] Length=180 Score = 355 bits (912), Expect = 7e-96, Method: Compositional matrix adjust. Identities = 179/180 (99%), Positives = 180/180 (100%), Gaps = 0/180 (0%) Query 253 LKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQ 312 +KAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQ Sbjct 1 MKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQ 60 Query 313 WLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLY 372 WLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLY Sbjct 61 WLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLY 120 Query 373 LAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS 432 LAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS Sbjct 121 LAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS 180 >gi|284988828|ref|YP_003407382.1| glutamate/cysteine ligase family protein [Geodermatophilus obscurus DSM 43160] gi|284062073|gb|ADB73011.1| glutamate/cysteine ligase family protein [Geodermatophilus obscurus DSM 43160] Length=418 Score = 340 bits (873), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 215/392 (55%), Positives = 253/392 (65%), Gaps = 2/392 (0%) Query 41 GPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPA 100 GP+G VGLE+EAH D A P R W+ IT +++ L LPGGS V++EPGG VELSGPP Sbjct 29 GPVGSVGLELEAHLVDLAAPATRVPWQRITGIVDALPALPGGSRVTLEPGGQVELSGPPY 88 Query 101 DGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHS 160 V AA+ A+ D+ VL +AL L + +GADPLR P RV P RY AME+ FAA Sbjct 89 PDVAAAVAALRADRDVLAAALVAERLAVAPVGADPLRPPARVCPAPRYAAMEEHFAAVGC 148 Query 161 GVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQST 220 G AMM TAA+QVNLDAGP GW+ERV LAH LGPT++A+AA SP+ GGR +GW S Sbjct 149 AEAGTAMMAGTAALQVNLDAGPCAGWSERVSLAHQLGPTLVAVAACSPLAGGRPTGWVSQ 208 Query 221 RQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDW 280 RQRVW +D ARCGP+LG G P +WA YAL APVM+V PD V + V F DW Sbjct 209 RQRVWSDLDQARCGPLLG--GADPAGEWAAYALAAPVMLVSDPDGGGAAPVRERVRFADW 266 Query 281 VDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDD 340 V G V L GR T ADL YHLTTLFPPVRPR +LEIRYLD+ P+ WPA+ LLDD Sbjct 267 VTGAVPLGGRAPTAADLDYHLTTLFPPVRPRGYLEIRYLDAAPEPWWPALAAVTAVLLDD 326 Query 341 PVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDH 400 PVAA A A PVA AWD AAR+GLAD L+ AA CLA A VP L ++ L D Sbjct 327 PVAAGHAAAATAPVAGAWDRAARVGLADPALHTAARTCLAAACAAVPVALRPEVEALADL 386 Query 401 VDRGVCPADDFSDRVIAGGIASAVTGMMHGAS 432 VDRG CP D D AGG +A+ +S Sbjct 387 VDRGRCPGDALLDTARAGGPTAALLSATEASS 418 >gi|269127843|ref|YP_003301213.1| glutamate/cysteine ligase family protein [Thermomonospora curvata DSM 43183] gi|268312801|gb|ACY99175.1| glutamate/cysteine ligase family protein [Thermomonospora curvata DSM 43183] Length=399 Score = 264 bits (675), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 171/393 (44%), Positives = 212/393 (54%), Gaps = 17/393 (4%) Query 31 EYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPG 90 E+ C GP G+VG E E DPADP E + E PLPG SV++ EPG Sbjct 11 EHTRGVCFKTGPPGKVGAETEWLVIDPADPAAHVPLERVRAAAEAGGPLPGRSVITYEPG 70 Query 91 GAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRA 150 G +ELS DG+ A+++D A +R+ LA GL LV G DPLR P RYR Sbjct 71 GQLELSSRVCDGLADLHEALSQDLASVRARLAADGLDLVGRGVDPLRRPRLQAAHPRYRC 130 Query 151 MEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA-ERVRLAHALGPTMIAIAANSPM 209 M +FA GA MM STA++QV LD G A R RLAHALGP ++A ANSP+ Sbjct 131 MYDYFAGGGYRETGATMMCSTASVQVCLDIGADPADALRRWRLAHALGPVLVAAFANSPL 190 Query 210 LGGRFSGWQSTRQRVWGQMDSARCGPIL--GASGDHPGIDWAKYALKAPVMMVR-SPDTQ 266 GR +G +STRQ +W +D R P+L G P W +YA+ APVM+ R P T Sbjct 191 RAGRRTGLRSTRQAIWAALDPCRTRPVLEAGTGPADPCRAWTRYAIDAPVMLTRPRPGTS 250 Query 267 DTRAVTDYVPFTDWVD-GRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDE 325 D + F +W+D G LD D YHL+TLFPPVRPR WLE+R +D++P Sbjct 251 DGWTGAPGMTFGEWMDKGEPCLD-------DFAYHLSTLFPPVRPRGWLELRMIDALPLR 303 Query 326 VWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARR 385 WP V LLDDP A +A DA PVA W AAR L D L LAA RC A A + Sbjct 304 YWPVPVAVATALLDDPQAGRIAEDAARPVAGRWGAAARHALTDPALALAARRCFAAALQA 363 Query 386 VPTELIGAMQRLV-----DHVDRGVCPADDFSD 413 +P + LV +V+RG CPADD +D Sbjct 364 LPRLGAAELVPLVADYARRYVERGRCPADDPAD 396 >gi|336180295|ref|YP_004585670.1| glutamate/cysteine ligase family protein [Frankia symbiont of Datisca glomerata] gi|334861275|gb|AEH11749.1| glutamate/cysteine ligase family protein [Frankia symbiont of Datisca glomerata] Length=545 Score = 262 bits (669), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 186/428 (44%), Positives = 229/428 (54%), Gaps = 31/428 (7%) Query 20 DVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFR----------------- 62 D +I Y CL D P G VG+E E D A P R Sbjct 57 DDKIRSPEDVHRYAHLTCLTDQPAGNVGIETEWFVVDIASPARPVPPGRTLTALTGSPPP 116 Query 63 RPSWEEITEVLEWLSP-----LPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVL 117 RPS + T P LPGG+ ++ EPGG +ELS PP + A+ D + Sbjct 117 RPSRDGETSPQTSPEPVDELFLPGGTRLTFEPGGQLELSAPPLP-LPDALARTATDLTAV 175 Query 118 RSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVN 177 R+ LA+AGL L +G DPLR P R RY AM+Q+F + G G AMM STA++QVN Sbjct 176 RAMLADAGLALAAMGTDPLRPPRRQLHAPRYVAMQQYFRRTDGGRAGEAMMCSTASVQVN 235 Query 178 LDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPIL 237 LDAG WA R LAHALGP ++A+ A SP+L G +GW+STRQ +W +D +R P+ Sbjct 236 LDAGATARWARRFELAHALGPVLVAMFAASPVLAGTATGWRSTRQSLWADIDPSRTSPVA 295 Query 238 GASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADL 297 P WA Y L A VM+VR PD D + D F DWV G + R TVADL Sbjct 296 APHQPDPATAWADYLLAARVMLVRLPD-GDFQLARDGSTFADWVAGAGPV-ARPPTVADL 353 Query 298 VYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA 357 YH TT+FPPVRPR WLE+RYLD+ P WP V LLDDP AAD A DA EPVA Sbjct 354 RYHATTVFPPVRPRGWLELRYLDAAPAGNWPVAVAVTTALLDDPRAADTAADACEPVAGR 413 Query 358 WDTAARIGLADRRLYLAANRCLAIAARR-----VPTELIGAMQRLVD-HVDRGVCPADDF 411 W TAA +GL D L+ AA RC A V L+ A+ ++ +V+ G CPADD Sbjct 414 WLTAAALGLRDDMLHRAARRCAGAARDALGHLGVDDALLAAVDTYLETYVEPGRCPADDL 473 Query 412 SDRVIAGG 419 DR+ A G Sbjct 474 IDRLPADG 481 >gi|312200432|ref|YP_004020493.1| glutamate/cysteine ligase family protein [Frankia sp. EuI1c] gi|311231768|gb|ADP84623.1| glutamate/cysteine ligase family protein [Frankia sp. EuI1c] Length=442 Score = 261 bits (667), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 184/399 (47%), Positives = 228/399 (58%), Gaps = 18/399 (4%) Query 38 LVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSP-LPGGSVVSVEPGGAVELS 96 L D +G+VG+E E D P + E L P LPGGS ++ EPGG ELS Sbjct 36 LADTAVGQVGIETEWFVVDRHSPDSPVAPERTRAALAGCGPDLPGGSRITFEPGGQFELS 95 Query 97 GPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFA 156 GPP + AA+ AM+ D +R LA+ GL L LGADPLR+P R+ +RY AME+FF Sbjct 96 GPPL-ALPAALRAMSADLTAVRLRLADDGLLLAGLGADPLRAPRRLLTHSRYAAMEEFF- 153 Query 157 ASHSGVP-GAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFS 215 G P G MM STAA+QVNL+AGP+ GW +R RLAH LGP ++A+ A+SP+L GR + Sbjct 154 -QTGGFPAGPLMMCSTAALQVNLEAGPRSGWEDRWRLAHTLGPVLVAMFASSPVLAGRPT 212 Query 216 GWQSTRQRVWGQMDSARCGPILGASGDH----PGIDWAKYALKAPVMMVRSPDTQDTRAV 271 G STRQ +W +D+ R P+ A P +WA+Y L A +M+VR D + V Sbjct 213 GQVSTRQGIWSDIDATRTTPVADAGTQFTTGGPAAEWARYLLDARLMLVRDGDDR-YLPV 271 Query 272 TDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVV 331 D F DWV G + RR TVADL YH +T+FPPVRPR WLE+RYLD+ +WP V Sbjct 272 RDGSTFADWVAGAGPVP-RRPTVADLAYHASTVFPPVRPRGWLELRYLDAQSPALWPVAV 330 Query 332 FTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAI---AARR--V 386 LLDDP AAD A DA VA W AA +GLA L AA RC+ AA R + Sbjct 331 TVAAALLDDPRAADTARDACAGVAGRWAEAAALGLAQPDLRTAALRCVMAVVEAAGRLGL 390 Query 387 PTELIGAMQRLVD-HVDRGVCPADDFSDRVIAGGIASAV 424 L A+ D V RG PAD AGG ASAV Sbjct 391 SPALTAAVADFADTFVRRGQSPADAALASWRAGG-ASAV 428 >gi|86743186|ref|YP_483586.1| glutamate--cysteine ligase, GCS2 [Frankia sp. CcI3] gi|86570048|gb|ABD13857.1| glutamate--cysteine ligase, GCS2 [Frankia sp. CcI3] Length=502 Score = 244 bits (623), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 166/369 (45%), Positives = 217/369 (59%), Gaps = 26/369 (7%) Query 83 SVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRV 142 S ++ EPGG +ELSGPPA+ + AA+ A + D ++RSALA GL LV +G DPLR +R Sbjct 132 SRITFEPGGQLELSGPPAE-LTAAVRASSADLNLVRSALAVDGLALVGMGVDPLRVGMRQ 190 Query 143 NPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAG--PQEGWAERVRLAHALGPTM 200 +RY AME+ F + G G MM STA++QVNLD G P E A R +L HALGP + Sbjct 191 TTASRYAAMEEHFR-TGGGASGTVMMYSTASVQVNLDLGGSPAEA-ARRFQLVHALGPVL 248 Query 201 IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGA-----SGD-HPGID--WAKYA 252 A+ A SP GR +GW+STRQ VW +D++R P+ A SGD P + WA+Y Sbjct 249 TALFAASPAYAGRRTGWRSTRQAVWDGIDASRTRPVAAALTAPGSGDTEPDLVDLWARYL 308 Query 253 LKAPVMMVRSP-------DTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLF 305 L A +MMV +P D V D F DW+ GR + R T DL YH TT+F Sbjct 309 LDAKLMMVENPARAGNPEDDHHFVPVRDDSTFGDWLAGRGPVT-RPPTREDLSYHATTVF 367 Query 306 PPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIG 365 PPVRPR W E+RYLD+ P + W A V LLDDPVAAD A +A VA W AA +G Sbjct 368 PPVRPRGWWELRYLDAQPGDGWQAAVAMPTVLLDDPVAADGAFEACLAVAHRWPAAAMLG 427 Query 366 LADRRLYLAANRC--LAIAARRV--PTELIGAMQRLVD-HVDRGVCPADDFSDRVIAGGI 420 +AD L AA RC LA++A R T+L ++ ++DRG CPAD+ ++R++A G Sbjct 428 MADEPLRRAAVRCVDLAVSALRRGGATDLAETVESFAGRYLDRGRCPADELTERLLAIGP 487 Query 421 ASAVTGMMH 429 A + H Sbjct 488 AGLLREEAH 496 >gi|288921440|ref|ZP_06415718.1| glutamate/cysteine ligase family protein [Frankia sp. EUN1f] gi|288347174|gb|EFC81473.1| glutamate/cysteine ligase family protein [Frankia sp. EUN1f] Length=572 Score = 238 bits (607), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 163/367 (45%), Positives = 204/367 (56%), Gaps = 23/367 (6%) Query 76 LSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADP 135 L LPGGS ++ EPGG +ELSGPP + A+ AM D ++R ALA GLGL LG DP Sbjct 196 LPSLPGGSRLTFEPGGQLELSGPPLP-LADAVAAMRGDLTLVRGALARHGLGLAGLGVDP 254 Query 136 LRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA-ERVRLAH 194 LR P R +RY AME+ F A G G MM STA++QVNLD+G ER RLAH Sbjct 255 LRPPRRHTAASRYVAMEEHFRAV-GGEAGLTMMCSTASVQVNLDSGADVAQTVERFRLAH 313 Query 195 ALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPIL------------GASGD 242 AL P +IA+ A SPM + WQS RQ VW ++D +R GP+L D Sbjct 314 ALEPVLIAMFAASPMPADQPIAWQSGRQEVWARIDPSRTGPVLPDPTVPPTDWNPRGGTD 373 Query 243 HPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWV-DGRVLLDGRRATVADLVYHL 301 H WA+Y A +MM+ + D + +AV F DW+ GR RR T DL +H Sbjct 374 HLAWLWARYLRDAHLMMI-AGDDGEYQAVGHRATFGDWLAGGRAAPSTRRPTRQDLGWHA 432 Query 302 TTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTA 361 TTLFPPVRPR WLE+RYLD+ P E+WP V L DDP+AA A+ A VA A Sbjct 433 TTLFPPVRPRGWLELRYLDAQPSELWPVPVAVASVLFDDPLAAREALAASVAVAGRARLA 492 Query 362 ARIGLADRRLYLAANRCLAIAARRVPT-----ELIGAMQRLVD-HVDRGVCPADDFSDRV 415 AR+GL D L+ AA RC+ +A + EL A++ D + R PADD S R+ Sbjct 493 ARLGLRDPALHRAAVRCVDLAVEALTRAGGDPELRLAVEAFADRYTRRRRSPADDLSLRL 552 Query 416 IAGGIAS 422 A G A Sbjct 553 AARGPAE 559 >gi|158319017|ref|YP_001511525.1| glutamate--cysteine ligase GCS2 [Frankia sp. EAN1pec] gi|158114422|gb|ABW16619.1| glutamate--cysteine ligase GCS2 [Frankia sp. EAN1pec] Length=472 Score = 236 bits (603), Expect = 4e-60, Method: Compositional matrix adjust. Identities = 166/377 (45%), Positives = 210/377 (56%), Gaps = 37/377 (9%) Query 79 LPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRS 138 LPGGS ++ EPGG +ELSGPP D + AA+ AM D A++R ALA LGLV +G DPLR+ Sbjct 87 LPGGSRLTFEPGGQLELSGPPLD-LTAAVDAMRADLALVRGALARRRLGLVGMGVDPLRT 145 Query 139 PVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA-ERVRLAHALG 197 PVR +RY AMEQ F A G MM STA++QVNLD G A ER RLAHAL Sbjct 146 PVRHTTASRYVAMEQHFLARDCDD-GRTMMCSTASVQVNLDIGTDTAQAVERFRLAHALE 204 Query 198 PTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPIL----------------GASG 241 P +IA+ A SP+ GR WQS RQ VW +D++R GP+L G G Sbjct 205 PVLIAMFAASPLAHGRQISWQSGRQAVWAGIDASRTGPVLPDPAAPATAWLAQAGPGGRG 264 Query 242 DHPGID----------WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRR 291 D PG WA+Y A +MMV PD + + V + F DW+ G + R Sbjct 265 DAPGAPPTGDAQLAWLWARYLHDADLMMVGEPDGR-YQPVRNRTTFGDWMAGAGPV-ARP 322 Query 292 ATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAV 351 T DL +H TTLFPPVRPR WLE+RYLD+ P ++WP V LLD+P AA A+ A Sbjct 323 PTAQDLGWHATTLFPPVRPRGWLELRYLDAQPSDLWPVAVAVPAVLLDEPAAARAALAAC 382 Query 352 EPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTE-----LIGAMQRLVD-HVDRGV 405 PVA AA++GL D L+ AA RC+ +A + L A++ + + RG Sbjct 383 LPVARQGRLAAQLGLRDPALHRAAVRCVDLALDTLARTGADPGLRAAVEAFANRYTRRGR 442 Query 406 CPADDFSDRVIAGGIAS 422 PADD + R A G A Sbjct 443 SPADDLNARFEARGPAE 459 >gi|111226173|ref|YP_716967.1| glutamate--cysteine ligase GSHA [Frankia alni ACN14a] gi|111153705|emb|CAJ65463.1| Glutamate--cysteine ligase GSHA (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) [Frankia alni ACN14a] Length=523 Score = 228 bits (582), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 168/383 (44%), Positives = 213/383 (56%), Gaps = 37/383 (9%) Query 79 LPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRS 138 LPGGS ++ EPGG +ELSGPPA G+ AA+ + D ++R+ALA GL +V +G DPLR+ Sbjct 140 LPGGSRLTFEPGGQLELSGPPA-GLAAAVQSTAADLHLVRAALAEDGLAIVGMGVDPLRA 198 Query 139 PVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAG--PQEGWAERVRLAHAL 196 VR +RY AME+ F + G G MM STA++QVNLD G P + AER RLAHA+ Sbjct 199 GVRQTTASRYAAMEEHFR-TGGGTSGEVMMRSTASVQVNLDLGTTPAQA-AERFRLAHAV 256 Query 197 GPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPIL------------------G 238 GP + A+ A SP L GR +GW+STRQ VW +D+ R G +L Sbjct 257 GPVLTAMFAASPALAGRRTGWRSTRQAVWSGIDAGRTGSVLDLPAQPAAGGDAGPGAAAA 316 Query 239 ASGDHPGIDWAKYALKAPVMMVRSP-----DTQDTR--AVTDYVPFTDWVDGRVLLDGRR 291 SGD WA+Y L A +MM+ P +D R A T F DWV GR ++ R Sbjct 317 RSGDL-ADRWARYLLAAKLMMIGDPLGDVGPGEDRRFVAATGGHTFGDWVAGRGPVE-RA 374 Query 292 ATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAV 351 T+ DL YH TTLFPPVRPR W E+RYLD+ P E W V LLDDPVAA A Sbjct 375 PTLDDLSYHATTLFPPVRPRGWWELRYLDAQPAEGWRVAVAVATALLDDPVAAAAAAQVC 434 Query 352 EPVATAWDTAARIGLADRRLYLAA----NRCLAIAARRVPTELIGAMQRLVD-HVDRGVC 406 PVA W AA +G+AD L LAA A R +L A++ + + RG C Sbjct 435 APVARRWPAAAMLGMADEPLRLAAVRCLELAAAALRRAGCADLADAVELFSERYPQRGRC 494 Query 407 PADDFSDRVIAGGIASAVTGMMH 429 PAD+ S+R I G A + H Sbjct 495 PADELSERFILIGPAGLLREEAH 517 >gi|297559615|ref|YP_003678589.1| glutamate/cysteine ligase family protein [Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] gi|296844063|gb|ADH66083.1| glutamate/cysteine ligase family protein [Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] Length=428 Score = 218 bits (556), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 159/393 (41%), Positives = 202/393 (52%), Gaps = 20/393 (5%) Query 31 EYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPG 90 EYI C GP G+VG E E D ADP + + ++E P P GS V+ EPG Sbjct 12 EYINGVCFKTGPPGKVGAETEWLVADSADPTAPVPVDRLAALVESCGPPPSGSGVTFEPG 71 Query 91 GAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRA 150 G +ELS P G A A++ D + ALA AGL LV DP R P R ARY A Sbjct 72 GQLELSSPALPGPARAHAALSADLDHVGKALAEAGLHLVETALDPARPPRRQLREARYTA 131 Query 151 MEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEG-WAERVRLAHALGPTMIAIAANSPM 209 ME+FF A H G MM STA++QV LD G +R L H LGP ++A ANS + Sbjct 132 MERFF-AHHRQPSGYTMMCSTASLQVCLDTGEDAADVRDRWELVHRLGPVLVAAFANSAV 190 Query 210 LGGRFSGWQSTRQRVWGQMDSARCGPILGA-SGDHPGIDWAKYALKAPVMMVRSPDTQDT 268 GR +GW+STR +W D+ R P+L A S P WA+YAL A VM V P + Sbjct 191 WRGRPTGWKSTRWAIWAATDATRTRPVLDAGSPADPATAWAEYALAARVMAV--PGGEGP 248 Query 269 RAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWP 328 V F+ W+DG+ R AT ADL +HL+TLFPPVRPR W E+R +D++P WP Sbjct 249 WTPDPGVTFSQWLDGQ---GPRPATRADLEFHLSTLFPPVRPRGWWELRMIDALPVRWWP 305 Query 329 AVVFTLVTLLDDPVAADLAVDAV-------EPVATAWDTAARIGLADRRLYLAANRCLAI 381 V L+DDP A A +A P W +AR+G+AD + A C Sbjct 306 VPVALAAALVDDPRARAAAEEATEELCGGRSPDRHLWLRSARLGMADPDVARCARACFDA 365 Query 382 AARRVPTELIGAMQRLVD-----HVDRGVCPAD 409 A +P ++ LVD H RG+ PAD Sbjct 366 AIEALPRMGAASLAALVDDYADHHTRRGLSPAD 398 >gi|302562250|ref|ZP_07314592.1| glutamate-cysteine ligase [Streptomyces griseoflavus Tu4000] gi|302479868|gb|EFL42961.1| glutamate-cysteine ligase [Streptomyces griseoflavus Tu4000] Length=438 Score = 213 bits (541), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 166/416 (40%), Positives = 218/416 (53%), Gaps = 36/416 (8%) Query 26 SSAAAEYIADG-CLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSV 84 + A E + G C GP R+G+E+E + DP S E + V L +P S Sbjct 16 TEAEVEALVRGICFKTGPPRRLGVEVEWLVHELRDPRLPVSPERLEAVYAALRTVPLRSA 75 Query 85 VSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNP 144 ++VEPGG +ELS PPA ++ +G ++ D +R+ L GL +V LG DP +P R Sbjct 76 LTVEPGGQLELSSPPAASLMECVGTVSADLDAVRAVLRRDGLAIVGLGHDPWHTPRRFLR 135 Query 145 GARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHALGPTM 200 RY AME +G G AMM ++A++QV LDAG +E G R LAH LG + Sbjct 136 APRYDAMEACL--DRTGPAGRAMMCTSASVQVCLDAGYEEPGPLGHVRRWWLAHQLGAVL 193 Query 201 IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARC-GPILGASGDHPGIDWAKYALKAPVMM 259 +A ANSP+ GGR +GW STRQ W Q+ + R GP+L A P WA++ L +PVM Sbjct 194 VAAFANSPIAGGRPTGWLSTRQLRWAQIGTGRAGGPVLDAD---PRGAWARHVLDSPVMC 250 Query 260 VRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYL 319 VR D V D + F +W R T DL YH TTLFPPVRPR LE+R + Sbjct 251 VRRDD--GPWHVPDGLTFREWTRS-----PRPPTRDDLDYHATTLFPPVRPRGHLELRMI 303 Query 320 DSVP-DEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAARIGLA 367 D+ P D+ W + L DDP AA+ A AV+P+A W AAR+GLA Sbjct 304 DAQPGDDGWIVPLAVAAALFDDPEAAETAYRAVKPLAERAHGMPAPHNPLWRDAARVGLA 363 Query 368 DRRLYLAANRCLAIAARRVP-----TELIGAMQRLVD-HVDRGVCPADDFSDRVIA 417 D L A C A A R +P TE++ A+ D HV RG CPADD D + A Sbjct 364 DPELREVAAACFAAALRALPRLGATTEVVDAVGAYRDRHVARGRCPADDSLDELRA 419 >gi|345003686|ref|YP_004806540.1| glutamate/cysteine ligase family protein [Streptomyces sp. SirexAA-E] gi|344319312|gb|AEN14000.1| glutamate/cysteine ligase family protein [Streptomyces sp. SirexAA-E] Length=433 Score = 212 bits (539), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 167/420 (40%), Positives = 219/420 (53%), Gaps = 38/420 (9%) Query 20 DVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPL 79 + E D A + + C GP VG+E+E D P S E +T + + Sbjct 14 EAEPLDEDEAQDRLRGICFKTGPPRTVGVELEWLIHDRERPEAAVSHERLTAAADAVRAT 73 Query 80 PGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSP 139 P S ++ EPGG +ELS PA + A + A++ D A +R+ LA +GL V LG DP + P Sbjct 74 PLDSALTFEPGGQLELSSRPAGSLTACVDAVSADMAAVRTVLARSGLEPVGLGVDPWQPP 133 Query 140 VRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHA 195 R+ RY AME A SG G AMM ++A++QV +DAG +E G+ R +L H Sbjct 134 RRLLKEPRYAAMEA--ALDRSGDSGRAMMCTSASVQVCVDAGEEEPGPLGFGRRWQLGHL 191 Query 196 LGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARC-GPILGASGDHPGIDWAKYALK 254 LG ++A ANSP G +GW+STRQ +W +D AR P + S P DWA Y L Sbjct 192 LGAVLVAAFANSPFRQGVRTGWRSTRQALWADLDPARSLAPPVRRS---PRDDWAGYVLD 248 Query 255 APVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWL 314 PVM +RS D AV + + F DW+ G R A ADL YH+TTLFPPVRPR L Sbjct 249 TPVMCIRS-DDGTPWAVPEGLTFRDWIRGG---GPRPAVRADLDYHVTTLFPPVRPRGHL 304 Query 315 EIRYLD--SVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTA 361 E+R +D S PD W + L DDP AA+ V+P+A W TA Sbjct 305 ELRMIDAQSGPDG-WLVPLAVTTALFDDPEAAETVYRTVKPLAETAGPSPAPRNPLWTTA 363 Query 362 ARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVD--------HVDRGVCPADDFSD 413 AR GLAD L AA C A A+R +P +GA R+ D +V RG CPADD +D Sbjct 364 ARDGLADPELAAAAKVCFAAASRALPG--LGASGRVQDAVAAFTDRYVVRGRCPADDLTD 421 >gi|271961911|ref|YP_003336107.1| glutamate/cysteine ligase [Streptosporangium roseum DSM 43021] gi|270505086|gb|ACZ83364.1| glutamate/cysteine ligase [Streptosporangium roseum DSM 43021] Length=408 Score = 211 bits (538), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 170/409 (42%), Positives = 212/409 (52%), Gaps = 24/409 (5%) Query 13 LDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEV 72 + + A +D+ I D+S ++ A C +VG+E+E FD P + V Sbjct 1 MTDLAAEDMVIRDTSDVTDF-ARNCFHGSAGDQVGVELEFLVFDRTSP---DCHVPLARV 56 Query 73 LEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLG 132 L PLPGGS V+ EPGG +ELSGP A + AI + D R+AL AGL L +G Sbjct 57 AGALPPLPGGSRVTFEPGGQLELSGP-AGPLPEAIARLAADVDAARAALREAGLVLAGVG 115 Query 133 ADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRL 192 DP+R R RY AM +F + G+ MM STA+IQVNLD G + A R Sbjct 116 LDPIRPARRQLRLPRYEAMAEFLGTPY----GSLMMCSTASIQVNLDLGDRP--AVRWER 169 Query 193 AHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYA 252 AH LGP + A ANSP+ GGR GW S RQ VW +D R P+ A+GD P WA+Y Sbjct 170 AHLLGPVLTAAFANSPLSGGRPCGWMSGRQAVWENLDRTRTAPV-PATGD-PAAAWAEYL 227 Query 253 LKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQ 312 L A +M+VR + R V D F DW+ R T+ADL YH TT+FPPVRPR Sbjct 228 LDARLMLVRE-NGDRCRTVRDGSTFRDWLAA----PARPLTLADLAYHATTIFPPVRPRG 282 Query 313 WLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLY 372 WLEIRYLD+ WP V L+ D AA+ A+ A EP A W AAR GLA+ RL Sbjct 283 WLEIRYLDAQRPADWPVCVAVTHALVMDDRAAETAIAAAEPYAGMWPGAARHGLAEPRLR 342 Query 373 LAANRCLAIAARRVP-----TELIGAMQRLVD-HVDRGVCPADDFSDRV 415 AA C A +P LI + D HV G PA D D V Sbjct 343 KAAETCFRAALAALPRLGVSAGLIREVAAFADRHVTTGRPPAADLLDLV 391 >gi|291435603|ref|ZP_06574993.1| conserved hypothetical protein [Streptomyces ghanaensis ATCC 14672] gi|291338498|gb|EFE65454.1| conserved hypothetical protein [Streptomyces ghanaensis ATCC 14672] Length=436 Score = 211 bits (538), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 165/419 (40%), Positives = 213/419 (51%), Gaps = 38/419 (9%) Query 27 SAAAEYIADG-CLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVV 85 A AE + G C GP R+G+E+E + DP S E + L +P S + Sbjct 17 EAEAEALVRGICFKTGPPRRLGVEVEWLVHESRDPRLPVSPERLEAAYAALRTVPLRSAL 76 Query 86 SVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPG 145 +VEPGG +ELS PPA ++ IG ++ D R+ L GL LV LG DP R+P R Sbjct 77 TVEPGGQLELSSPPAASLMECIGTVSADLDAARAVLREDGLVLVGLGHDPWRAPRRFLRE 136 Query 146 ARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHALGPTMI 201 RY AME +G G AMM ++A++QV LDAG +E G R LAH LG ++ Sbjct 137 PRYDAMEACL--DRTGPAGRAMMCASASVQVCLDAGYEEPGPLGHVRRWWLAHQLGAVLV 194 Query 202 AIAANSPMLGGRFSGWQSTRQRVWGQMDSARC-GPILGASGDHPGIDWAKYALKAPVMMV 260 A+ ANSP+ G R +GW STRQ W ++ + R GP L A P W ++ L APVM V Sbjct 195 AVFANSPIAGDRPTGWLSTRQLHWTRIGADRAGGPALDAD---PRGAWVRHVLDAPVMCV 251 Query 261 RSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLD 320 R V + + F +W V R T DL YHLTTLFPPVRPR LE+R +D Sbjct 252 RR--DGGPWDVPEGLTFREWTRSGV---PRPPTREDLDYHLTTLFPPVRPRGHLELRMID 306 Query 321 SVP-DEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAARIGLAD 368 + P D+ W + L DDP AA+ A AV+P+A W AAR+G AD Sbjct 307 AQPGDDGWIVPLALTAALFDDPEAAETAYRAVKPLAERARGLPAPHNPLWRDAARVGPAD 366 Query 369 RRLYLAANRCLAIAARRVPTELIGAMQRLVD--------HVDRGVCPADDFSDRVIAGG 419 L A C A A +P IGA + D +V RG CPADD D + GG Sbjct 367 PELREVAATCFAAALSALPR--IGATTEVTDAVAAYHDRYVARGRCPADDLLDSLRDGG 423 >gi|325002083|ref|ZP_08123195.1| glutamate--cysteine ligase GCS2 [Pseudonocardia sp. P1] Length=372 Score = 207 bits (527), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 149/362 (42%), Positives = 193/362 (54%), Gaps = 22/362 (6%) Query 23 ITDSSAAAE-YIADGCLVDGPLGRVGLEME---AHCFDPADP-----FRRPSWEEITEVL 73 + S AAAE Y+A C GP VG+E+E H PADP R L Sbjct 15 VLRSRAAAEAYVASVCFKHGPPALVGVEIEWMLHHPDRPADPVDPDLLRTALGAHTPPAL 74 Query 74 EWLS---PLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVF 130 + S PLP G VV+VEPGG +E+S P+DG+ IG +T D A L LA GL Sbjct 75 DPASHGLPLPAGGVVTVEPGGQIEISSAPSDGLTPLIGDVTADAAHLHELLARYGLHPHA 134 Query 131 LGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERV 190 ADP+R R+ RY AME F G G + M ST+A+QV+LDAGP + A+R Sbjct 135 RAADPVRPAQRLLDLPRYAAMECVF--DQVGPHGRSGMCSTSAVQVSLDAGPADTVADRW 192 Query 191 RLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPI-LGASGDHPGIDWA 249 + H LGP ++A ANSP+ GR +GW+S+RQ W +D +R P L A+G+ P WA Sbjct 193 AVLHELGPVLLAAFANSPVQHGRRTGWKSSRQACWLSLDPSRTAPPELLAAGEDPAAAWA 252 Query 250 KYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDG---RRATVADLVYHLTTLFP 306 + + P++ VR + AV V F DW G V DG R T+ADL YH++TLFP Sbjct 253 RRVVDTPLLCVRG---TGSWAVPSGVTFADWASGAV-RDGILARPPTLADLDYHVSTLFP 308 Query 307 PVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGL 366 PVRP+ LE+RY+D P + W L+ L D + EPV AW AAR L Sbjct 309 PVRPQGHLEVRYVDGQPGDDWAVPAAVLLALTSSDGVVDRVREICEPVRDAWVPAARDAL 368 Query 367 AD 368 AD Sbjct 369 AD 370 >gi|256376253|ref|YP_003099913.1| glutamate--cysteine ligase GCS2 [Actinosynnema mirum DSM 43827] gi|255920556|gb|ACU36067.1| glutamate--cysteine ligase GCS2 [Actinosynnema mirum DSM 43827] Length=408 Score = 207 bits (527), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 153/379 (41%), Positives = 184/379 (49%), Gaps = 30/379 (7%) Query 6 MTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEME---AHCFDPADP-- 60 M AA P D + A Y+A C GP +G+E+E H DP+ P Sbjct 1 MVAAVHPSPAHGPAPASFRDRAEAEAYVASVCFKHGPPRLIGVEIEWTVHHLGDPSLPVD 60 Query 61 ---FRRPSWEEITEVLEWLSP---LPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQ 114 F + L SP LP G+ ++VEPGG VE+S PP D + + + D Sbjct 61 AALFSAALGDHAPPTLVPDSPQRTLPSGTPLTVEPGGQVEISTPPRDSLTELLKTVASDV 120 Query 115 AVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAI 174 L L AG L GADP R P R+ RYRAM+ F A G G MM STA + Sbjct 121 DHLAGLLEPAGFTLGDRGADPFRPPRRLLDVPRYRAMQHAFDAL--GPDGLTMMCSTAGL 178 Query 175 QVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCG 234 QV LDAG A R AHALGP ++A+ ANSP +GGR W S R R D RC Sbjct 179 QVCLDAGEGPDVATRWAAAHALGPALMALFANSPGVGGRRPDWASARMRTLYGTDPVRCR 238 Query 235 PILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVP-----FTDWVDGRVLLDG 289 P GA D P WA+ L APV++VR P D++P F DWVDG + Sbjct 239 P--GAVCDDPASAWARRVLDAPVIVVRRPGP-------DWIPPHRLTFADWVDGAL---D 286 Query 290 RRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVD 349 RR T DL YHLT FPPVRPR +LEIRYLD+ W V L L P D ++ Sbjct 287 RRPTTEDLDYHLTLQFPPVRPRGYLEIRYLDTPGPGGWIPPVVLLAALFSHPSVVDSVLE 346 Query 350 AVEPVATAWDTAARIGLAD 368 A P W TAAR GL D Sbjct 347 ATGPSVRRWLTAARHGLDD 365 >gi|315505720|ref|YP_004084607.1| glutamate/cysteine ligase family protein [Micromonospora sp. L5] gi|315412339|gb|ADU10456.1| glutamate/cysteine ligase family protein [Micromonospora sp. L5] Length=411 Score = 204 bits (519), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 152/364 (42%), Positives = 183/364 (51%), Gaps = 24/364 (6%) Query 21 VEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSP-- 78 V + D AA ++A C GP VG+E+E D ADP R E + E L SP Sbjct 11 VVLGDEEAARGHLARICFKTGPPALVGVELEWTVHDAADPARPVDRERLREALGRHSPVT 70 Query 79 ---------LPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLV 129 L G V+VEPGG VE+S P V A I A D A LR+ L AGL L Sbjct 71 LDPTSPADELRRGGAVTVEPGGQVEISATPRSSVAALILATEADVAELRARLDAAGLVLG 130 Query 130 FLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAER 189 G DP R P V RYRAM F G G AMM STA +QV LDAG E A+R Sbjct 131 RSGIDPWRLPRPVVETPRYRAMRCAF--DRRGPAGRAMMYSTAGLQVCLDAGEPEHVAQR 188 Query 190 VRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGA--SGDHPGID 247 AHA+GP ++A A + GR +GW S R W +D AR P+ + + P Sbjct 189 WAAAHAVGPPLLAAFATADRHAGRRTGWASARMATWLAIDPARTRPVWSPERADEDPVAA 248 Query 248 WAKYALKAPVMMVRS--PDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLF 305 W YAL AP++ VR PD VT F DW+ G + R T DL YHL+TLF Sbjct 249 WTGYALAAPLLCVRGDGPDWTAPPGVT----FADWLAGAL---PRPPTTDDLEYHLSTLF 301 Query 306 PPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIG 365 PPVRPR +LE+RYLD+ P W + L L DP A+ A PVA W AAR G Sbjct 302 PPVRPRGYLELRYLDTQPGPEWTVPLAVLAALFADPATTRDALAAAGPVADRWRAAARCG 361 Query 366 LADR 369 LA+R Sbjct 362 LAER 365 >gi|345011675|ref|YP_004814029.1| glutamate/cysteine ligase family protein [Streptomyces violaceusniger Tu 4113] gi|344038024|gb|AEM83749.1| glutamate/cysteine ligase family protein [Streptomyces violaceusniger Tu 4113] Length=418 Score = 204 bits (519), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 163/416 (40%), Positives = 208/416 (50%), Gaps = 32/416 (7%) Query 18 PDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLS 77 PDD I+++ A + C GP R+G+E+E +DP P R + + L Sbjct 2 PDDKAISEAEMEAR-LHGICFKTGPPRRIGVELEWLLYDPHIPARPIEAARLEAAVTALR 60 Query 78 PLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLR 137 LP S ++ EPGG VELS PAD + + + D ++RS LA GLGL G DP R Sbjct 61 GLPLRSAITFEPGGQVELSSLPADSLTECVESAAADLVLVRSLLAGLGLGLAGHGHDPWR 120 Query 138 SPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLA 193 P R RY ME +F G G +MM STA++QV +DAG +E G A R RLA Sbjct 121 PPRRFLTTPRYECMETYF--DRRGPAGRSMMCSTASVQVCVDAGHEEPGPLGMARRWRLA 178 Query 194 HALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYAL 253 H LG + A ANSP+ GR +G++STRQ VW M+ R G P WA Y L Sbjct 179 HLLGAVLTAAFANSPLRQGRPTGYRSTRQAVWTAMEPGRTH--APPDGGDPRTAWAHYVL 236 Query 254 KAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQW 313 APVM +R D + AV V F W R L R T+ DL +H +TLFPPVRPR Sbjct 237 DAPVMAIR--DEKGPWAVPSGVTFRQW--ARTGLP-RPPTLDDLDFHASTLFPPVRPRGH 291 Query 314 LEIRYLDSVPDE-VWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTA 361 LE+R +D+ E W + V L DDP AA+ V+P+A W A Sbjct 292 LELRMIDAQSGEDGWIVPLAVTVALFDDPQAAETVYRVVKPLAETAGARPAPGNRLWRAA 351 Query 362 ARIGLADRRLYLAANRCLAIAARRVPT-----ELIGAMQRLVD-HVDRGVCPADDF 411 AR GLAD L AA C A A +P + A+ D +V RG CPADD Sbjct 352 ARHGLADPELRAAAVSCFATALDALPRIGASPAITAAVAAFTDRYVARGRCPADDL 407 >gi|302867878|ref|YP_003836515.1| glutamate/cysteine ligase family protein [Micromonospora aurantiaca ATCC 27029] gi|302570737|gb|ADL46939.1| glutamate/cysteine ligase family protein [Micromonospora aurantiaca ATCC 27029] Length=411 Score = 202 bits (515), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 151/364 (42%), Positives = 183/364 (51%), Gaps = 24/364 (6%) Query 21 VEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSP-- 78 V + D AA ++A C GP VG+E+E D ADP R E + E L SP Sbjct 11 VVLGDEEAARGHLARICFKTGPPALVGVELEWTVHDAADPARPVDRERLREALGRHSPVT 70 Query 79 ---------LPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLV 129 L G V+VEPGG VE+S P V A I A D A LR+ L AGL L Sbjct 71 LDPTSPADELRRGGAVTVEPGGQVEISATPRSSVAALILATEADVAELRARLDAAGLVLG 130 Query 130 FLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAER 189 G DP R P V RY+AM F G G AMM STA +QV LDAG E A+R Sbjct 131 RSGIDPWRLPRPVVETPRYQAMRCAF--DRRGPAGRAMMYSTAGLQVCLDAGEPEHVAQR 188 Query 190 VRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGA--SGDHPGID 247 AHA+GP ++A A + GR +GW S R W +D AR P+ + + P Sbjct 189 WAAAHAVGPPLLAAFATADRHAGRRTGWASARMATWLAIDPARTRPVWSPERADEDPVAA 248 Query 248 WAKYALKAPVMMVRS--PDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLF 305 W YAL AP++ VR PD VT F DW+ G + R T DL YHL+TLF Sbjct 249 WTGYALAAPLLCVRGDGPDWTAPPGVT----FADWLAGAL---PRPPTTDDLEYHLSTLF 301 Query 306 PPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIG 365 PPVRPR +LE+RYLD+ P W + L L DP A+ A PVA W AAR G Sbjct 302 PPVRPRGYLELRYLDTQPGPEWTVPLAVLAALFADPATTRDALAAAGPVADRWRAAARCG 361 Query 366 LADR 369 LA+R Sbjct 362 LAER 365 >gi|302555740|ref|ZP_07308082.1| glutamate-cysteine ligase [Streptomyces viridochromogenes DSM 40736] gi|302473358|gb|EFL36451.1| glutamate-cysteine ligase [Streptomyces viridochromogenes DSM 40736] Length=437 Score = 202 bits (515), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 158/412 (39%), Positives = 208/412 (51%), Gaps = 34/412 (8%) Query 26 SSAAAEYIADG-CLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSV 84 + A E + G C GP R+G+E+E + P + E + L + S Sbjct 20 NEAEVEALVRGICFKTGPPRRLGVEVEWLVHELHTPQLPVTPERLQAAYAALRTVSLRSA 79 Query 85 VSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNP 144 ++VEPGG +ELS PPA + I ++ D +R+AL + GL LV LG DP P R Sbjct 80 LTVEPGGQLELSSPPAASLTECIRTVSADLDTVRAALRDDGLALVGLGHDPWHEPRRFLR 139 Query 145 GARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHALGPTM 200 RY AME +G G AMM ++A++QV LDAG +E G+ R LAH LGP + Sbjct 140 EPRYDAMEACL--DRTGPAGRAMMCASASVQVCLDAGHEEPGPLGFVRRWWLAHHLGPVL 197 Query 201 IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARC-GPILGASGDHPGIDWAKYALKAPVMM 259 +A ANSP+ G R +GW STRQ W ++ R GP L A P WA++ L +PVM Sbjct 198 VAAFANSPLAGHRPTGWVSTRQLTWTRIGPGRAGGPPLDAD---PRGAWARHVLDSPVMC 254 Query 260 VRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYL 319 VR V + + F +W + R T DL YHLTTLFPPVRPR LE+R + Sbjct 255 VRR--DGGPWDVPEGLTFREWTRKGL---PRPPTHQDLDYHLTTLFPPVRPRGHLELRMI 309 Query 320 DSVP-DEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAARIGLA 367 D+ P D+ W + L DDP AA+ A AV+P+A W AAR GLA Sbjct 310 DAQPGDDGWIVPLAVTTALFDDPEAAETAYRAVKPLAERTLGLPAPHNPLWLDAARDGLA 369 Query 368 DRRLYLAANRCLAIAARRVPT-----ELIGAMQRLVDH-VDRGVCPADDFSD 413 D L A C A +P E+ A+ +DH V RG CPADD D Sbjct 370 DAELREVAVSCFTAALEALPRLGAGPEVTDAVTAYLDHYVVRGRCPADDLLD 421 >gi|117165100|emb|CAJ88654.1| putative glutamate-cysteine ligase [Streptomyces ambofaciens ATCC 23877] Length=433 Score = 202 bits (514), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 158/415 (39%), Positives = 209/415 (51%), Gaps = 36/415 (8%) Query 24 TDSSAAAEYIADG-CLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGG 82 T + A E + G C GP R+G+E+E + +P S E + V L +P Sbjct 14 TATEAEVEALVHGICFKTGPPTRLGVEVEWLVHELREPRLPVSPERLDAVYTALRAVPLR 73 Query 83 SVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRV 142 S ++VEPGG +ELS PA + + ++ D A +R+ L GLGLV LG DP + P R Sbjct 74 SALTVEPGGQLELSSLPAASLTECVDTVSADLAAVRAVLREDGLGLVGLGHDPWQVPRRF 133 Query 143 NPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHALGP 198 RY AME G G MM ++A++QV LDAG +E G R LAH LG Sbjct 134 LRQPRYDAMEACL--DRGGPAGRYMMCTSASVQVCLDAGHEEPGPLGHVRRWWLAHQLGA 191 Query 199 TMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARC-GPILGASGDHPGIDWAKYALKAPV 257 ++A ANSP+ GGR +GW+STRQ W Q+ R GP L P W ++ L APV Sbjct 192 VLLAAFANSPLAGGRLTGWRSTRQLRWAQIGPGRAGGPALDTD---PRGTWTRHVLDAPV 248 Query 258 MMVRSPDTQDTRAVTDYVPFTDWV-DGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEI 316 M VR V + + F +W+ GR R T+ DL YHLTTLFPPVRPR LE+ Sbjct 249 MCVRR--DGGPWDVPEGLTFREWIRSGRP----RPPTLEDLDYHLTTLFPPVRPRGHLEL 302 Query 317 RYLDSVP-DEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAARI 364 R +D+ P D+ W + L DDP A + A AV+P+ ++ AAR Sbjct 303 RMIDAQPGDDGWRVPLAVTAALFDDPEATETAYRAVKPLTERTLGRPAPHNPLYEDAARD 362 Query 365 GLADRRLYLAANRCLAIAARRVP-----TELIGAMQ-RLVDHVDRGVCPADDFSD 413 L D L AA C A +P TE+ A+ L +V RG CPADD D Sbjct 363 ALTDPELREAAVTCFEAALAALPRLGATTEVTDAVAGHLERYVRRGRCPADDLLD 417 >gi|297204104|ref|ZP_06921501.1| glutamate-cysteine ligase [Streptomyces sviceus ATCC 29083] gi|197714770|gb|EDY58804.1| glutamate-cysteine ligase [Streptomyces sviceus ATCC 29083] Length=434 Score = 202 bits (514), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 157/404 (39%), Positives = 208/404 (52%), Gaps = 37/404 (9%) Query 37 CLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELS 96 C GP R+G+E+E + +P + E++ L +P S ++VEPGG +ELS Sbjct 33 CFKTGPPRRIGVEVEWLVHELRNPRLPVTSEQLAAAYAALRAVPLKSALTVEPGGQLELS 92 Query 97 GPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFA 156 PAD ++ IG ++ D A +R+ALA GLGLV LG DP P R RY AME Sbjct 93 SQPADSLMECIGTVSADLAAVRAALAEHGLGLVGLGHDPWHPPRRYLREPRYDAMEACL- 151 Query 157 ASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHALGPTMIAIAANSPMLGG 212 +G G AMM ++A++QV +DAG +E G R LAH LGP ++A ANSP+ G Sbjct 152 -DRTGPAGRAMMCTSASVQVCVDAGHEEPGPLGLGRRWSLAHQLGPVLVAAFANSPLAGS 210 Query 213 RFSGWQSTRQRVWGQMDSARCGPILGASGD-HPGIDWAKYALKAPVMMVRSPDTQDTRAV 271 +GW STRQ W ++ R G G S D P W ++ L APVM +R + Sbjct 211 EPTGWLSTRQLRWTEIGKGRAG---GPSLDTDPRSAWTRHVLDAPVMCIRR--DSGPWDI 265 Query 272 TDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDE-VWPAV 330 + + F +W V R T DL YH++TLFPPVRPR LE+R +D+ P E W Sbjct 266 PEGLSFREWARSGV---PRPPTREDLDYHVSTLFPPVRPRGHLELRMIDAQPGEDGWIVP 322 Query 331 VFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAARIGLADRRLYLAANRCL 379 + L DDP AA+ A V+P+A W AAR GLAD L AA C Sbjct 323 LAVTAALFDDPQAAETAYRVVKPLAERTLSMPAPHNPLWIDAARHGLADPELCEAAIACF 382 Query 380 AIAARRVP--------TELIGAMQRLVDHVDRGVCPADDFSDRV 415 A A +P T+ +GA L +V RG CPADD DR Sbjct 383 AAALEALPRLGATTEVTDAVGAY--LHRYVIRGRCPADDLLDRT 424 >gi|291449352|ref|ZP_06588742.1| glutamate-cysteine ligase [Streptomyces roseosporus NRRL 15998] gi|291352299|gb|EFE79203.1| glutamate-cysteine ligase [Streptomyces roseosporus NRRL 15998] Length=436 Score = 202 bits (513), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 153/419 (37%), Positives = 206/419 (50%), Gaps = 37/419 (8%) Query 20 DVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPL 79 D D S A + + C GP VG+E+E D P E + + +E + L Sbjct 12 DATPLDESGAEDLLRGICFKTGPPRTVGVELEWLIHDRERPHVPVGQERLDDAVEAVRAL 71 Query 80 PGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSP 139 P + ++ EPGG +ELS PA ++ + D A +R++L AGL V LG DP ++P Sbjct 72 PLSAALTFEPGGQLELSSQPAGSLMECVATTAADLAAVRASLGTAGLAPVGLGVDPWQTP 131 Query 140 VRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHA 195 R RY AME A +G G AMM ++A++QV LDAG +E G+ R +LAH Sbjct 132 HRRLREPRYEAMEA--ALDRAGPAGRAMMCTSASVQVCLDAGEEEPGPLGYGRRWQLAHL 189 Query 196 LGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKA 255 LG ++A ANSP GR +GW STRQ +W +D R + +G P WA + L Sbjct 190 LGAVLVAAFANSPFQQGRRTGWSSTRQALWADLDPGRT--LAPGTGRAPCEAWAAHVLDT 247 Query 256 PVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLE 315 V+ +R V + + F +W+ V R ADL YHLTTLFPPVRPR LE Sbjct 248 TVLCIRC--ESGPWDVPEGLTFREWIRTGV---PRPPVQADLDYHLTTLFPPVRPRGHLE 302 Query 316 IRYLD--SVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAA 362 +R +D S PD W + L DDP AA+ AV+P+A W AA Sbjct 303 LRMIDAQSGPDG-WVVPLAVATALFDDPEAAETVYRAVKPLAETAGTAAAPRNPLWTAAA 361 Query 363 RIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVD--------HVDRGVCPADDFSD 413 R GLAD L AA C A + E +GA + D +V RG CPADD + Sbjct 362 RGGLADPELRAAAVTCFGAALPAL--ERMGASDAVRDTVAAFTDRYVARGRCPADDLPE 418 >gi|294632553|ref|ZP_06711113.1| glutamate-cysteine ligase [Streptomyces sp. e14] gi|292835886|gb|EFF94235.1| glutamate-cysteine ligase [Streptomyces sp. e14] Length=432 Score = 202 bits (513), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 159/414 (39%), Positives = 215/414 (52%), Gaps = 34/414 (8%) Query 26 SSAAAEYIADG-CLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSV 84 + A E + G C GP +G+E+E + +P + E + L +P S Sbjct 2 TEAEVEALVSGICFKTGPPRTLGVEVEWLVHELREPRLPVTPERLEAAYAALRTVPLKSA 61 Query 85 VSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNP 144 ++VEPGG +ELS PPA ++ +G ++ D A +R+ LA GL LV LG D P R Sbjct 62 LTVEPGGQLELSSPPAASLMECVGTVSADLAAVRAVLAAKGLRLVGLGHDLWHPPRRFLR 121 Query 145 GARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHALGPTM 200 RY A+E G G MM ++A++QV +DAG +E G R LAH LGP + Sbjct 122 ERRYDALEASL--DRGGPAGRHMMCTSASVQVCVDAGHEEPGPLGHVRRWWLAHQLGPVL 179 Query 201 IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCG-PILGASGDHPGIDWAKYALKAPVMM 259 +A ANSP+L R +GW+STRQ +W ++ R G P L S P WA++ L APVM Sbjct 180 VAAFANSPLLVRRPTGWRSTRQLLWTEIGPGRAGAPPLDGS---PRTAWARHVLDAPVMC 236 Query 260 VRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYL 319 VR D V D + F WV V R T DL YHLTTLFPPVRPR LE+R + Sbjct 237 VRRDD--GPWEVPDGLTFRQWVRSGV---PRPPTKEDLDYHLTTLFPPVRPRGHLELRMI 291 Query 320 DSVP-DEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAARIGLA 367 D+ P D+ W + L DDP AA+ A AV+P+A W AAR GL Sbjct 292 DAQPGDDGWIVPLAVTAALFDDPAAAESAYRAVKPLAERALGRPAPHNPLWTAAARSGLG 351 Query 368 DRRLYLAANRCLAIAARRVPT-----ELIGAMQRLVD-HVDRGVCPADDFSDRV 415 D L+ AA C A +P E++ A++ +D +V +G CPADD DR+ Sbjct 352 DPELHEAAIACFLAALEALPRLGASDEVVRAVRGHLDRYVLKGRCPADDLLDRL 405 >gi|239992362|ref|ZP_04713026.1| putative glutamylcysteine synthetase [Streptomyces roseosporus NRRL 11379] Length=438 Score = 201 bits (512), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 153/419 (37%), Positives = 206/419 (50%), Gaps = 37/419 (8%) Query 20 DVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPL 79 D D S A + + C GP VG+E+E D P E + + +E + L Sbjct 14 DATPLDESGAEDLLRGICFKTGPPRTVGVELEWLIHDRERPHVPVGQERLDDAVEAVRAL 73 Query 80 PGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSP 139 P + ++ EPGG +ELS PA ++ + D A +R++L AGL V LG DP ++P Sbjct 74 PLSAALTFEPGGQLELSSQPAGSLMECVATTAADLAAVRASLGTAGLAPVGLGVDPWQTP 133 Query 140 VRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHA 195 R RY AME A +G G AMM ++A++QV LDAG +E G+ R +LAH Sbjct 134 HRRLREPRYEAMEA--ALDRAGPAGRAMMCTSASVQVCLDAGEEEPGPLGYGRRWQLAHL 191 Query 196 LGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKA 255 LG ++A ANSP GR +GW STRQ +W +D R + +G P WA + L Sbjct 192 LGAVLVAAFANSPFQQGRRTGWSSTRQALWADLDPGRT--LAPGTGRAPCEAWAAHVLDT 249 Query 256 PVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLE 315 V+ +R V + + F +W+ V R ADL YHLTTLFPPVRPR LE Sbjct 250 TVLCIRC--ESGPWDVPEGLTFREWIRTGV---PRPPVQADLDYHLTTLFPPVRPRGHLE 304 Query 316 IRYLD--SVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAA 362 +R +D S PD W + L DDP AA+ AV+P+A W AA Sbjct 305 LRMIDAQSGPDG-WVVPLAVATALFDDPEAAETVYRAVKPLAETAGTAAAPRNPLWTAAA 363 Query 363 RIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVD--------HVDRGVCPADDFSD 413 R GLAD L AA C A + E +GA + D +V RG CPADD + Sbjct 364 RGGLADPELRAAAVTCFGAALPAL--ERMGASDAVRDTVAAFTDRYVARGRCPADDLPE 420 >gi|329938527|ref|ZP_08287952.1| Glutamate-cysteine ligase [Streptomyces griseoaurantiacus M045] gi|329302500|gb|EGG46391.1| Glutamate-cysteine ligase [Streptomyces griseoaurantiacus M045] Length=426 Score = 201 bits (512), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 164/429 (39%), Positives = 215/429 (51%), Gaps = 36/429 (8%) Query 6 MTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPS 65 M+ A S + A D +T++ A + C GP R+G+E+E +P P Sbjct 1 MSEAVSDCKDGAEDRTALTEADVEA-LVRGICFKTGPPRRLGVELEWLVHEPLRPRLPVR 59 Query 66 WEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAG 125 E + L LP S ++VEPGG +ELS PA ++ + +++ D +R+AL G Sbjct 60 PERLDAAYAALRTLPLSSALTVEPGGQLELSSAPAASLMECVRSVSADLDTVRAALRADG 119 Query 126 LGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE- 184 LGL G +P PVR RY AME +G G AMM S+A++QV LDAG +E Sbjct 120 LGLYGCGHEPWNPPVRYLRQPRYDAMEACL--DRTGPEGRAMMCSSASVQVCLDAGYEEP 177 Query 185 ---GWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCG-PILGAS 240 G R LAH LG ++A A+SP+ GR +GW+STRQ +W MD R G P LG Sbjct 178 GPLGHGRRWWLAHTLGAVLVAAFAHSPVARGRPTGWRSTRQYLWTAMDPGRSGAPPLGPD 237 Query 241 GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH 300 P WA+ L APVM VR D V + + F +W T ADL YH Sbjct 238 ---PRGAWAERVLDAPVMCVRRED--GPWDVPEGLTFREWTRS-----AEGPTRADLEYH 287 Query 301 LTTLFPPVRPRQWLEIRYLDSVPD-EVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-- 357 LTTLFPPVRPR LE+R +D+ P + W + L DDP AA+ A AV+P+A Sbjct 288 LTTLFPPVRPRGHLELRMIDAQPGPDGWIVPLAVTTALFDDPEAAETAYRAVKPLAERAD 347 Query 358 ---------WDTAARIGLADRRLYLAANRCLAIAARRVP-----TELIGAMQRLVD-HVD 402 W TAAR GL D L AA C A AA +P + A+ + HV Sbjct 348 ALAAPRNPLWTTAAREGLNDPELREAATVCFAAAAEALPRLGADEAVRAAVAEFTERHVA 407 Query 403 RGVCPADDF 411 RG CPADD Sbjct 408 RGRCPADDL 416 >gi|302548228|ref|ZP_07300570.1| glutamate-cysteine ligase [Streptomyces hygroscopicus ATCC 53653] gi|302465846|gb|EFL28939.1| glutamate-cysteine ligase [Streptomyces himastatinicus ATCC 53653] Length=428 Score = 201 bits (511), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 150/415 (37%), Positives = 205/415 (50%), Gaps = 33/415 (7%) Query 20 DVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPL 79 D + D + + C GP R+G+E+E +DP DP + + + L L Sbjct 13 DSKAIDEAEMEARLHGICFKTGPPRRIGVELEWLMYDPHDPAQPIEAARLEAAVTALRGL 72 Query 80 PGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSP 139 S ++ EPGG +ELS PAD + A + + D ++R+ LA GL + G DP R P Sbjct 73 GLASALTFEPGGQLELSSLPADSLTACVESAAADLVLVRALLAELGLAIAGHGHDPWRPP 132 Query 140 VRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQE----GWAERVRLAHA 195 R+ RY +ME +F + G G +MM +TA++QV +DAG +E G R RLAH Sbjct 133 RRILTTPRYDSMETYF--NRRGPAGRSMMCNTASVQVCVDAGQEEPGPLGLGRRWRLAHL 190 Query 196 LGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDH-PGIDWAKYALK 254 LG + A ANSP+ GR +G++STRQ +W MD R L D P W Y L Sbjct 191 LGAVLTAAFANSPLREGRPTGFRSTRQALWAAMDPGR---TLAPPDDRDPRTAWTGYVLD 247 Query 255 APVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWL 314 APVM +R D AV D + F W R L R T DL +H++TLFPP+RPR L Sbjct 248 APVMAIR--DDGTPWAVPDGLTFRQW--ARTGLP-RPPTQDDLDFHVSTLFPPIRPRGHL 302 Query 315 EIRYLDSVP-DEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATA-----------WDTAA 362 E+R +D+ D+ W + V L DDP AA+ V+P+A W TA Sbjct 303 ELRMIDAQSGDDGWIVPLAVTVALFDDPEAAETVYRVVKPLAETAGARPAPCNPLWMTAT 362 Query 363 RIGLADRRLYLAANRCLAIAARRVPT-----ELIGAMQRLVD-HVDRGVCPADDF 411 R L D L A C A A +P ++ A+ D +V RG CPADD Sbjct 363 RDALTDPELRNTAVACFATALEALPRIGASPAVVSAVADFADRYVARGRCPADDL 417 Lambda K H 0.320 0.135 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 886607207280 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40