BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3710 Length=644 Score E Sequences producing significant alignments: (Bits) Value gi|298527187|ref|ZP_07014596.1| 2-isopropylmalate synthase leua ... 1325 0.0 gi|148663575|ref|YP_001285098.1| 2-isopropylmalate synthase [Myc... 1323 0.0 gi|253722697|pdb|3FIG|A Chain A, Crystal Structure Of Leucine-Bo... 1321 0.0 gi|340628684|ref|YP_004747136.1| 2-isopropylmalate synthase [Myc... 1320 0.0 gi|49259127|pdb|1SR9|A Chain A, Crystal Structure Of Leua From M... 1291 0.0 gi|289748228|ref|ZP_06507606.1| 2-isopropylmalate synthase leuA ... 1286 0.0 gi|289572361|ref|ZP_06452588.1| 2-isopropylmalate synthase [Myco... 1276 0.0 gi|289445309|ref|ZP_06435053.1| 2-isopropylmalate synthase [Myco... 1276 0.0 gi|339633702|ref|YP_004725344.1| 2-isopropylmalate synthase [Myc... 1266 0.0 gi|121639626|ref|YP_979850.1| 2-isopropylmalate synthase [Mycoba... 1243 0.0 gi|289441145|ref|ZP_06430889.1| 2-isopropylmalate synthase [Myco... 1243 0.0 gi|161350053|ref|NP_338367.2| 2-isopropylmalate synthase [Mycoba... 1242 0.0 gi|224992122|ref|YP_002646811.1| 2-isopropylmalate synthase [Myc... 1242 0.0 gi|289571954|ref|ZP_06452181.1| 2-isopropylmalate synthase leuA ... 1241 0.0 gi|254552820|ref|ZP_05143267.1| 2-isopropylmalate synthase [Myco... 1241 0.0 gi|39931368|sp|Q7TVV6.1|LEU1_MYCBO RecName: Full=2-isopropylmala... 1239 0.0 gi|289755839|ref|ZP_06515217.1| 2-isopropylmalate synthase leuA ... 1164 0.0 gi|161511524|ref|NP_857375.2| 2-isopropylmalate synthase [Mycoba... 1157 0.0 gi|254818514|ref|ZP_05223515.1| 2-isopropylmalate synthase [Myco... 1101 0.0 gi|1850985|gb|AAB48096.1| putative alpha-isopropyl malate syntha... 1090 0.0 gi|183985194|ref|YP_001853485.1| 2-isopropylmalate synthase LeuA... 1079 0.0 gi|342861923|ref|ZP_08718567.1| 2-isopropylmalate synthase [Myco... 1073 0.0 gi|41394759|gb|AAS02629.1| LeuA [Mycobacterium avium subsp. para... 1066 0.0 gi|336460887|gb|EGO39772.1| 2-isopropylmalate synthase [Mycobact... 1063 0.0 gi|254773396|ref|ZP_05214912.1| 2-isopropylmalate synthase [Myco... 1062 0.0 gi|118463994|ref|YP_879677.1| 2-isopropylmalate synthase [Mycoba... 1062 0.0 gi|296166803|ref|ZP_06849222.1| 2-isopropylmalate synthase [Myco... 1051 0.0 gi|161611210|ref|NP_959246.2| 2-isopropylmalate synthase [Mycoba... 1041 0.0 gi|240172823|ref|ZP_04751482.1| 2-isopropylmalate synthase [Myco... 1030 0.0 gi|118619454|ref|YP_907786.1| 2-isopropylmalate synthase [Mycoba... 1027 0.0 gi|108801861|ref|YP_642058.1| 2-isopropylmalate synthase [Mycoba... 1019 0.0 gi|221230726|ref|YP_002504142.1| 2-isopropylmalate synthase [Myc... 1013 0.0 gi|54013780|dbj|BAD55150.1| putative 2-isopropylmalate synthase ... 993 0.0 gi|145221885|ref|YP_001132563.1| 2-isopropylmalate synthase [Myc... 989 0.0 gi|226363561|ref|YP_002781343.1| 2-isopropylmalate synthase [Rho... 987 0.0 gi|169627441|ref|YP_001701090.1| 2-isopropylmalate synthase [Myc... 984 0.0 gi|111021202|ref|YP_704174.1| 2-isopropylmalate synthase [Rhodoc... 984 0.0 gi|333992633|ref|YP_004525247.1| 2-isopropylmalate synthase LeuA... 982 0.0 gi|161723262|ref|NP_302512.2| 2-isopropylmalate synthase [Mycoba... 976 0.0 gi|226303900|ref|YP_002763858.1| 2-isopropylmalate synthase [Rho... 974 0.0 gi|229492151|ref|ZP_04385960.1| 2-isopropylmalate synthase [Rhod... 974 0.0 gi|296141655|ref|YP_003648898.1| 2-isopropylmalate synthase [Tsu... 969 0.0 gi|161598448|ref|YP_116514.2| 2-isopropylmalate synthase [Nocard... 969 0.0 gi|326383510|ref|ZP_08205197.1| 2-isopropylmalate synthase [Gord... 962 0.0 gi|120406458|ref|YP_956287.1| 2-isopropylmalate synthase [Mycoba... 962 0.0 gi|118470831|ref|YP_890490.1| 2-isopropylmalate synthase [Mycoba... 961 0.0 gi|312137917|ref|YP_004005253.1| 2-isopropylmalate synthase leua... 957 0.0 gi|262200473|ref|YP_003271681.1| 2-isopropylmalate synthase [Gor... 956 0.0 gi|325673308|ref|ZP_08153000.1| 2-isopropylmalate synthase [Rhod... 929 0.0 gi|343926431|ref|ZP_08765936.1| 2-isopropylmalate synthase [Gord... 922 0.0 >gi|298527187|ref|ZP_07014596.1| 2-isopropylmalate synthase leua [Mycobacterium tuberculosis 94_M4241A] gi|308378447|ref|ZP_07482611.2| 2-isopropylmalate synthase [Mycobacterium tuberculosis SUMu009] gi|13883692|gb|AAK48181.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis CDC1551] gi|298496981|gb|EFI32275.1| 2-isopropylmalate synthase leua [Mycobacterium tuberculosis 94_M4241A] gi|308352507|gb|EFP41358.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis SUMu009] Length=659 Score = 1325 bits (3428), Expect = 0.0, Method: Compositional matrix adjust. Identities = 644/644 (100%), Positives = 644/644 (100%), Gaps = 0/644 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 16 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 75 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 76 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 135 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 136 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 195 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 196 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 255 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 256 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 315 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 316 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 375 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 376 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 435 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 436 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 495 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 496 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 555 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 556 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 615 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 616 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 659 >gi|148663575|ref|YP_001285098.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis H37Ra] gi|148824915|ref|YP_001289669.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis F11] gi|253800756|ref|YP_003033757.1| 2-isopropylmalate synthase leuA [Mycobacterium tuberculosis KZN 1435] 43 more sequence titles Length=644 Score = 1323 bits (3423), Expect = 0.0, Method: Compositional matrix adjust. Identities = 643/644 (99%), Positives = 644/644 (100%), Gaps = 0/644 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 1 MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 >gi|253722697|pdb|3FIG|A Chain A, Crystal Structure Of Leucine-Bound Leua From Mycobacterium Tuberculosis gi|253722698|pdb|3FIG|B Chain B, Crystal Structure Of Leucine-Bound Leua From Mycobacterium Tuberculosis Length=646 Score = 1321 bits (3418), Expect = 0.0, Method: Compositional matrix adjust. Identities = 642/644 (99%), Positives = 643/644 (99%), Gaps = 0/644 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 + TSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 3 MATSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 62 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 63 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 122 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 123 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 182 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 183 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 242 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 243 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 302 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 303 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 362 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 363 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 422 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 423 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 482 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 483 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 542 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 543 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 602 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 603 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 646 >gi|340628684|ref|YP_004747136.1| 2-isopropylmalate synthase [Mycobacterium canettii CIPT 140010059] gi|340006874|emb|CCC46063.1| 2-isopropylmalate synthase LEUA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) [Mycobacterium canettii CIPT 140010059] Length=644 Score = 1320 bits (3417), Expect = 0.0, Method: Compositional matrix adjust. Identities = 641/644 (99%), Positives = 643/644 (99%), Gaps = 0/644 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 1 MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLER+RQHVDAADDDGGTTSI ATVKINGVETEISGSGNGPLAAFVH Sbjct 481 WDAFAEEYLAPVRPLERMRQHVDAADDDGGTTSIMATVKINGVETEISGSGNGPLAAFVH 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 >gi|49259127|pdb|1SR9|A Chain A, Crystal Structure Of Leua From Mycobacterium Tuberculosis gi|49259128|pdb|1SR9|B Chain B, Crystal Structure Of Leua From Mycobacterium Tuberculosis Length=644 Score = 1291 bits (3342), Expect = 0.0, Method: Compositional matrix adjust. Identities = 632/643 (99%), Positives = 632/643 (99%), Gaps = 0/643 (0%) Query 2 TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNR 61 TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASS PVNRYRPFAEEVEPIRLRNR Sbjct 2 TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSXPVNRYRPFAEEVEPIRLRNR 61 Query 62 TWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTD 121 TWPDRVIDRAPLWCAVDLRDGNQALIDP SPARKRR FDLLVR GYKEIEVGFPSASQTD Sbjct 62 TWPDRVIDRAPLWCAVDLRDGNQALIDPXSPARKRRXFDLLVRXGYKEIEVGFPSASQTD 121 Query 122 FDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVF 181 FDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVF Sbjct 122 FDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVF 181 Query 182 RANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAP 241 RANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAP Sbjct 182 RANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAP 241 Query 242 TPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGF 301 TPERPIIFNLPATVE TTPNVYADSIEW SRNLANRESVILSLHPHNDRGTAVAAAELGF Sbjct 242 TPERPIIFNLPATVEXTTPNVYADSIEWXSRNLANRESVILSLHPHNDRGTAVAAAELGF 301 Query 302 AAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVH 361 AAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVH Sbjct 302 AAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVH 361 Query 362 ERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRT 421 ERHPYGGDLVYTAFSGSHQDAINKGLDA KLDADAADCDVDD LWQVPYLPIDPRDVGRT Sbjct 362 ERHPYGGDLVYTAFSGSHQDAINKGLDAXKLDADAADCDVDDXLWQVPYLPIDPRDVGRT 421 Query 422 YEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMW 481 YEAVIRVNSQSGKGGVAYI KTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKE W Sbjct 422 YEAVIRVNSQSGKGGVAYIXKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEXW 481 Query 482 DAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHA 541 DAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHA Sbjct 482 DAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHA 541 Query 542 LADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQ 601 LADVGFDVAVLDYYEHA SAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQ Sbjct 542 LADVGFDVAVLDYYEHAXSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQ 601 Query 602 PGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 PGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 602 PGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 >gi|289748228|ref|ZP_06507606.1| 2-isopropylmalate synthase leuA [Mycobacterium tuberculosis T92] gi|289688815|gb|EFD56244.1| 2-isopropylmalate synthase leuA [Mycobacterium tuberculosis T92] Length=678 Score = 1286 bits (3328), Expect = 0.0, Method: Compositional matrix adjust. Identities = 643/663 (97%), Positives = 644/663 (98%), Gaps = 19/663 (2%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 16 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 75 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 76 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 135 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 136 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 195 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 196 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 255 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 256 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 315 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 316 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 375 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 376 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 435 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 436 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 495 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 496 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 555 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEAS-------------------VTIASPA 581 ALADVGFDVAVL+YYEHAMSAGDDAQAAAYVEAS VTIASPA Sbjct 556 ALADVGFDVAVLNYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 615 Query 582 QPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNR 641 QPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNR Sbjct 616 QPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNR 675 Query 642 AAR 644 AAR Sbjct 676 AAR 678 >gi|289572361|ref|ZP_06452588.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis K85] gi|289536792|gb|EFD41370.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis K85] Length=697 Score = 1276 bits (3302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 644/682 (95%), Positives = 644/682 (95%), Gaps = 38/682 (5%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 16 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 75 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 76 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 135 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 136 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 195 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 196 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 255 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 256 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 315 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 316 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 375 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 376 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 435 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 436 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 495 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 496 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 555 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGR------------ 588 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGR Sbjct 556 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 615 Query 589 --------------------------HASDPVTIASPAQPGEAGRHASDPVTSKTVWGVG 622 HASDPVTIASPAQPGEAGRHASDPVTSKTVWGVG Sbjct 616 QPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVG 675 Query 623 IAPSITTASLRAVVSAVNRAAR 644 IAPSITTASLRAVVSAVNRAAR Sbjct 676 IAPSITTASLRAVVSAVNRAAR 697 >gi|289445309|ref|ZP_06435053.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis CPHL_A] gi|289418267|gb|EFD15468.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis CPHL_A] Length=700 Score = 1276 bits (3302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 644/682 (95%), Positives = 644/682 (95%), Gaps = 38/682 (5%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 19 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 78 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 79 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 138 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 139 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 198 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 199 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 258 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 259 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 318 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 319 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 378 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 379 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 438 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 439 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 498 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 499 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 558 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGR------------ 588 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGR Sbjct 559 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 618 Query 589 --------------------------HASDPVTIASPAQPGEAGRHASDPVTSKTVWGVG 622 HASDPVTIASPAQPGEAGRHASDPVTSKTVWGVG Sbjct 619 QPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVG 678 Query 623 IAPSITTASLRAVVSAVNRAAR 644 IAPSITTASLRAVVSAVNRAAR Sbjct 679 IAPSITTASLRAVVSAVNRAAR 700 >gi|339633702|ref|YP_004725344.1| 2-isopropylmalate synthase [Mycobacterium africanum GM041182] gi|339333058|emb|CCC28788.1| 2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) [Mycobacterium africanum GM041182] Length=614 Score = 1266 bits (3277), Expect = 0.0, Method: Compositional matrix adjust. Identities = 613/614 (99%), Positives = 614/614 (100%), Gaps = 0/614 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 1 MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 Query 601 QPGEAGRHASDPVT 614 QPGEAGRHASDPVT Sbjct 601 QPGEAGRHASDPVT 614 >gi|121639626|ref|YP_979850.1| 2-isopropylmalate synthase [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|121495274|emb|CAL73760.1| 2-isopropylmalate synthase leuA [Mycobacterium bovis BCG str. Pasteur 1173P2] Length=834 Score = 1243 bits (3217), Expect = 0.0, Method: Compositional matrix adjust. Identities = 612/614 (99%), Positives = 613/614 (99%), Gaps = 0/614 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 1 MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGA RAIVHFYNSTSILQRRVV Sbjct 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAHRAIVHFYNSTSILQRRVV 180 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 Query 601 QPGEAGRHASDPVT 614 QPGEAGRHASDPVT Sbjct 601 QPGEAGRHASDPVT 614 Score = 136 bits (343), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 71/79 (90%), Positives = 73/79 (93%), Gaps = 0/79 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP 625 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP Sbjct 756 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP 815 Query 626 SITTASLRAVVSAVNRAAR 644 SITTASLRAVVSAVNRAAR Sbjct 816 SITTASLRAVVSAVNRAAR 834 Score = 81.6 bits (200), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 642 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 690 Score = 81.6 bits (200), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 661 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 709 Score = 81.6 bits (200), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 680 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 728 Score = 81.6 bits (200), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 699 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 747 >gi|289441145|ref|ZP_06430889.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis T46] gi|289414064|gb|EFD11304.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis T46] Length=701 Score = 1243 bits (3215), Expect = 0.0, Method: Compositional matrix adjust. Identities = 614/614 (100%), Positives = 614/614 (100%), Gaps = 0/614 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 8 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 67 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 68 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 127 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 128 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 187 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 188 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 247 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 248 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 307 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 308 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 367 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 368 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 427 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 428 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 487 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 488 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 547 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 548 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 607 Query 601 QPGEAGRHASDPVT 614 QPGEAGRHASDPVT Sbjct 608 QPGEAGRHASDPVT 621 Score = 82.0 bits (201), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 649 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 697 Score = 52.4 bits (124), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 26/34 (77%), Positives = 28/34 (83%), Gaps = 0/34 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASP 599 +A + VTIASPAQPGEAGRHASDPVTIASP Sbjct 668 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASP 701 >gi|161350053|ref|NP_338367.2| 2-isopropylmalate synthase [Mycobacterium tuberculosis CDC1551] gi|167970865|ref|ZP_02553142.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis H37Ra] gi|294995380|ref|ZP_06801071.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis 210] 8 more sequence titles Length=604 Score = 1242 bits (3214), Expect = 0.0, Method: Compositional matrix adjust. Identities = 604/604 (100%), Positives = 604/604 (100%), Gaps = 0/604 (0%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY Sbjct 121 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV Sbjct 181 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD Sbjct 301 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV Sbjct 361 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI Sbjct 421 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 480 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP Sbjct 481 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 540 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN Sbjct 541 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 600 Query 641 RAAR 644 RAAR Sbjct 601 RAAR 604 >gi|224992122|ref|YP_002646811.1| 2-isopropylmalate synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|224775237|dbj|BAH28043.1| 2-isopropylmalate synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341603647|emb|CCC66328.1| 2-isopropylmalate synthase leuA [Mycobacterium bovis BCG str. Moreau RDJ] Length=815 Score = 1242 bits (3213), Expect = 0.0, Method: Compositional matrix adjust. Identities = 612/614 (99%), Positives = 613/614 (99%), Gaps = 0/614 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 1 MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGA RAIVHFYNSTSILQRRVV Sbjct 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAHRAIVHFYNSTSILQRRVV 180 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 Query 601 QPGEAGRHASDPVT 614 QPGEAGRHASDPVT Sbjct 601 QPGEAGRHASDPVT 614 Score = 136 bits (343), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 71/79 (90%), Positives = 73/79 (93%), Gaps = 0/79 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP 625 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP Sbjct 737 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP 796 Query 626 SITTASLRAVVSAVNRAAR 644 SITTASLRAVVSAVNRAAR Sbjct 797 SITTASLRAVVSAVNRAAR 815 Score = 82.0 bits (201), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 642 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 690 Score = 82.0 bits (201), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 661 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 709 Score = 82.0 bits (201), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 680 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 728 >gi|289571954|ref|ZP_06452181.1| 2-isopropylmalate synthase leuA [Mycobacterium tuberculosis T17] gi|289545708|gb|EFD49356.1| 2-isopropylmalate synthase leuA [Mycobacterium tuberculosis T17] Length=695 Score = 1241 bits (3212), Expect = 0.0, Method: Compositional matrix adjust. Identities = 613/614 (99%), Positives = 614/614 (100%), Gaps = 0/614 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 1 MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV Sbjct 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 Query 601 QPGEAGRHASDPVT 614 QPGEAGRHASDPVT Sbjct 601 QPGEAGRHASDPVT 614 Score = 82.4 bits (202), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 642 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 690 Score = 53.9 bits (128), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 27/35 (78%), Positives = 29/35 (83%), Gaps = 0/35 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 +A + VTIASPAQPGEAGRHASDPVTIASPA Sbjct 661 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPA 695 >gi|254552820|ref|ZP_05143267.1| 2-isopropylmalate synthase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] Length=604 Score = 1241 bits (3210), Expect = 0.0, Method: Compositional matrix adjust. Identities = 603/604 (99%), Positives = 604/604 (100%), Gaps = 0/604 (0%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY Sbjct 121 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV Sbjct 181 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAM+LDADAADCD Sbjct 301 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMELDADAADCD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV Sbjct 361 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI Sbjct 421 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 480 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP Sbjct 481 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 540 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN Sbjct 541 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 600 Query 641 RAAR 644 RAAR Sbjct 601 RAAR 604 >gi|39931368|sp|Q7TVV6.1|LEU1_MYCBO RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase gi|31620480|emb|CAD95923.1| 2-ISOPROPYLMALATE SYNTHASE LEUA (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) [Mycobacterium bovis AF2122/97] Length=701 Score = 1239 bits (3207), Expect = 0.0, Method: Compositional matrix adjust. Identities = 612/614 (99%), Positives = 613/614 (99%), Gaps = 0/614 (0%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +TTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN Sbjct 1 MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGA RAIVHFYNSTSILQRRVV Sbjct 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAHRAIVHFYNSTSILQRRVV 180 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA Sbjct 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR Sbjct 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM Sbjct 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH Sbjct 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA Sbjct 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 Query 601 QPGEAGRHASDPVT 614 QPGEAGRHASDPVT Sbjct 601 QPGEAGRHASDPVT 614 >gi|289755839|ref|ZP_06515217.1| 2-isopropylmalate synthase leuA [Mycobacterium tuberculosis EAS054] gi|289696426|gb|EFD63855.1| 2-isopropylmalate synthase leuA [Mycobacterium tuberculosis EAS054] Length=756 Score = 1164 bits (3011), Expect = 0.0, Method: Compositional matrix adjust. Identities = 574/574 (100%), Positives = 574/574 (100%), Gaps = 0/574 (0%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY Sbjct 121 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV Sbjct 181 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD Sbjct 301 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV Sbjct 361 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI Sbjct 421 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 480 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP Sbjct 481 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 540 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 541 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 574 Score = 137 bits (344), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 71/79 (90%), Positives = 73/79 (93%), Gaps = 0/79 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP 625 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP Sbjct 678 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAP 737 Query 626 SITTASLRAVVSAVNRAAR 644 SITTASLRAVVSAVNRAAR Sbjct 738 SITTASLRAVVSAVNRAAR 756 Score = 82.0 bits (201), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 602 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 650 Score = 82.0 bits (201), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/49 (84%), Positives = 43/49 (88%), Gaps = 0/49 (0%) Query 566 QAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 +A + VTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 621 EAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 669 >gi|161511524|ref|NP_857375.2| 2-isopropylmalate synthase [Mycobacterium bovis AF2122/97] Length=661 Score = 1157 bits (2994), Expect = 0.0, Method: Compositional matrix adjust. Identities = 573/574 (99%), Positives = 573/574 (99%), Gaps = 0/574 (0%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 A RAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY Sbjct 121 AHRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV Sbjct 181 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD Sbjct 301 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV Sbjct 361 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI Sbjct 421 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 480 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP Sbjct 481 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 540 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 614 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT Sbjct 541 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVT 574 >gi|254818514|ref|ZP_05223515.1| 2-isopropylmalate synthase [Mycobacterium intracellulare ATCC 13950] Length=618 Score = 1101 bits (2847), Expect = 0.0, Method: Compositional matrix adjust. Identities = 548/641 (86%), Positives = 580/641 (91%), Gaps = 25/641 (3%) Query 4 SESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTW 63 + + DA++ + +IVKPAGPP GQP+WNPQR SSMPV+RYRPFAEEVEPIRL +RTW Sbjct 2 TSNSDAFSST---RSIVKPAGPPGPGQPAWNPQRGSSMPVSRYRPFAEEVEPIRLADRTW 58 Query 64 PDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 123 PDRVI APLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD Sbjct 59 PDRVITSAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 118 Query 124 FVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRA 183 FVREII GAIPDDVTIQVLTQCRPELIERTF+AC GAP+AIVHFYNSTSILQRRVVFRA Sbjct 119 FVREIITDGAIPDDVTIQVLTQCRPELIERTFEACQGAPQAIVHFYNSTSILQRRVVFRA 178 Query 184 NRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTP 243 +A VQ IAT GARKCVE+AAKYPGT+WRFEYSPESYTGTELEYAKQVCDAVGE+I PTP Sbjct 179 EKAAVQDIATAGARKCVEEAAKYPGTRWRFEYSPESYTGTELEYAKQVCDAVGEIIGPTP 238 Query 244 ERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAA 303 E PIIFNLPATVEM TPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG+ A Sbjct 239 ENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYQA 298 Query 304 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 363 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER Sbjct 299 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 358 Query 364 HPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYE 423 HPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DV+DMLWQVPYLPIDP+DVGRTYE Sbjct 359 HPYGGDLVYTAFSGSHQDAINKGLDQMKVDADAADTDVEDMLWQVPYLPIDPKDVGRTYE 418 Query 424 AVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDA 483 AVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQV+QKI T GEGGEVSPKEMWDA Sbjct 419 AVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVVQKI---TDGEGGEVSPKEMWDA 475 Query 484 FAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALA 543 F+EEYLAPV PLER++Q VDA+++D G TSI ATVKINGVETEISGSGNGPLAAFVHAL Sbjct 476 FSEEYLAPVWPLERVKQRVDASEEDSGVTSIAATVKINGVETEISGSGNGPLAAFVHALG 535 Query 544 DVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPG 603 DVGFDVAVLDY EHAMS+GDDAQAAAYVEASV+IAS A+PGE Sbjct 536 DVGFDVAVLDYSEHAMSSGDDAQAAAYVEASVSIASAAEPGE------------------ 577 Query 604 EAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 AGRH S PV ++TVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 578 -AGRHPSGPVGARTVWGVGIAPSITTASLRAVVSAVNRAAR 617 >gi|1850985|gb|AAB48096.1| putative alpha-isopropyl malate synthase [Mycobacterium tuberculosis H37Rv] Length=558 Score = 1090 bits (2819), Expect = 0.0, Method: Compositional matrix adjust. Identities = 546/552 (99%), Positives = 547/552 (99%), Gaps = 2/552 (0%) Query 90 MSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPE 149 MSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPE Sbjct 1 MSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPE 60 Query 150 LIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGT 209 LIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGT Sbjct 61 LIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGT 120 Query 210 QWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEW 269 QWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEW Sbjct 121 QWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEW 180 Query 270 MSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGL 329 MSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGL Sbjct 181 MSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGL 240 Query 330 NLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDA 389 NLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDA Sbjct 241 NLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDA 300 Query 390 MKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSL 449 MKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSL Sbjct 301 MKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSL 360 Query 450 PRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDG 509 PRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDG Sbjct 361 PRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDG 420 Query 510 GTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAA 569 GTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAA Sbjct 421 GTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAA 480 Query 570 YVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITT 629 YVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSI Sbjct 481 YVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSINR 540 Query 630 ASLRAVVSAVNR 641 + AVVSAVNR Sbjct 541 PA--AVVSAVNR 550 >gi|183985194|ref|YP_001853485.1| 2-isopropylmalate synthase LeuA [Mycobacterium marinum M] gi|183178520|gb|ACC43630.1| 2-isopropylmalate synthase LeuA [Mycobacterium marinum M] Length=606 Score = 1079 bits (2791), Expect = 0.0, Method: Compositional matrix adjust. Identities = 544/638 (86%), Positives = 567/638 (89%), Gaps = 41/638 (6%) Query 7 PDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDR 66 PDA+T A TIVKPAGPP GQP WNPQRASSMPVNRYRPFAEEVE IR+ +RTWPDR Sbjct 10 PDAFT---SARTIVKPAGPPSPGQPVWNPQRASSMPVNRYRPFAEEVEHIRVTDRTWPDR 66 Query 67 VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVR 126 VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVR Sbjct 67 VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVR 126 Query 127 EIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRA 186 EII +GAIPDDVTIQVLTQCRPELIERTF+AC+GA + IVHFYNSTSILQRRVVFRA+RA Sbjct 127 EIITEGAIPDDVTIQVLTQCRPELIERTFEACAGASKVIVHFYNSTSILQRRVVFRADRA 186 Query 187 EVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERP 246 VQAIAT+GAR+CVE+AAKYP TQWRFEYSPESYTGTELEYAKQVCDAV EVI PTPE P Sbjct 187 AVQAIATEGARRCVEEAAKYPDTQWRFEYSPESYTGTELEYAKQVCDAVAEVIQPTPENP 246 Query 247 IIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGAD 306 IIFNLPATVEM TPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGAD Sbjct 247 IIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGAD 306 Query 307 RIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPY 366 RIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV ERHPY Sbjct 307 RIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVPERHPY 366 Query 367 GGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVI 426 GGDLVYTAFSGSHQDAINKGLDAMK DADAAD D+DDMLWQVPYLPIDP+DVGRTYEAVI Sbjct 367 GGDLVYTAFSGSHQDAINKGLDAMKFDADAADSDMDDMLWQVPYLPIDPKDVGRTYEAVI 426 Query 427 RVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAE 486 RVNSQSGKGGVAYIMK DHGL+LPRRLQIEFS+ IQ+IAEG+AGEGGEVSPKEMWDAFAE Sbjct 427 RVNSQSGKGGVAYIMKADHGLALPRRLQIEFSRAIQEIAEGSAGEGGEVSPKEMWDAFAE 486 Query 487 EYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVG 546 EYLAPVRPLERI+Q V AA++DGGTTSI ATVKI+G ETEISGSGNGPLAAFVHAL VG Sbjct 487 EYLAPVRPLERIKQRVIAAEEDGGTTSIDATVKIDGKETEISGSGNGPLAAFVHALGSVG 546 Query 547 FDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAG 606 FDVAVLDY EHAMSAGDDAQAAAYVEAS Sbjct 547 FDVAVLDYSEHAMSAGDDAQAAAYVEAS-------------------------------- 574 Query 607 RHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V KTVWGVGIAPSITTASLRAVVSA+NRA+R Sbjct 575 ------VAGKTVWGVGIAPSITTASLRAVVSAINRASR 606 >gi|342861923|ref|ZP_08718567.1| 2-isopropylmalate synthase [Mycobacterium colombiense CECT 3035] gi|342130463|gb|EGT83772.1| 2-isopropylmalate synthase [Mycobacterium colombiense CECT 3035] Length=602 Score = 1073 bits (2776), Expect = 0.0, Method: Compositional matrix adjust. Identities = 535/641 (84%), Positives = 564/641 (88%), Gaps = 41/641 (6%) Query 4 SESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTW 63 + +PDA++ + TIV+PAGPP GQP WN QR SSMPVNRYRPFAEEVEPIRL +RTW Sbjct 2 TSNPDAFSST---RTIVQPAGPPGPGQPVWNLQRGSSMPVNRYRPFAEEVEPIRLTDRTW 58 Query 64 PDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 123 PDRV+D APLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTD+D Sbjct 59 PDRVLDSAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDYD 118 Query 124 FVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRA 183 FVREII GAIPDDVTIQVLTQCRPELIERTF AC GAP+AIVHFYNSTSILQRRVVFRA Sbjct 119 FVREIITDGAIPDDVTIQVLTQCRPELIERTFDACHGAPQAIVHFYNSTSILQRRVVFRA 178 Query 184 NRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTP 243 +RA VQAIAT+GARKC E+AAKYPGT+WRFEYSPESYTGTELEYAKQVCDAVGE+I PTP Sbjct 179 DRAAVQAIATEGARKCAEEAAKYPGTRWRFEYSPESYTGTELEYAKQVCDAVGEIIGPTP 238 Query 244 ERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAA 303 E PIIFNLPATVEM TPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG+ A Sbjct 239 ENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYQA 298 Query 304 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 363 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER Sbjct 299 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 358 Query 364 HPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYE 423 HPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DV+DMLWQVPYLPIDP+DVGRTYE Sbjct 359 HPYGGDLVYTAFSGSHQDAINKGLDQMKVDADAADTDVEDMLWQVPYLPIDPKDVGRTYE 418 Query 424 AVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDA 483 AVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQVIQKIAEGTAGEG EVSPKEMWDA Sbjct 419 AVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVIQKIAEGTAGEGSEVSPKEMWDA 478 Query 484 FAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALA 543 F+EEYLAPV PLERI+Q VDA+++D G T ITATVK+NG ETEISG GNGPLAAFVHAL Sbjct 479 FSEEYLAPVSPLERIKQRVDASEEDSGITRITATVKLNGAETEISGEGNGPLAAFVHALG 538 Query 544 DVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPG 603 VGFDVAVLDY EHAMS+GDDAQAAAYVEAS Sbjct 539 SVGFDVAVLDYSEHAMSSGDDAQAAAYVEAS----------------------------- 569 Query 604 EAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVGIAPSIT+ASLRAVVSAVNRAAR Sbjct 570 ---------VDGRTVWGVGIAPSITSASLRAVVSAVNRAAR 601 >gi|41394759|gb|AAS02629.1| LeuA [Mycobacterium avium subsp. paratuberculosis K-10] Length=614 Score = 1066 bits (2758), Expect = 0.0, Method: Compositional matrix adjust. Identities = 535/644 (84%), Positives = 565/644 (88%), Gaps = 44/644 (6%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 +T + PDA++ S +IVKPAGPP GQP+WNPQR SSMPVNRYRPFAEEVEPIRL + Sbjct 14 ITVTSHPDAFSSS---RSIVKPAGPPGPGQPAWNPQRGSSMPVNRYRPFAEEVEPIRLPD 70 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPD+VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 71 RTWPDKVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 130 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREII +GAIPDDVTIQVLTQCRPELIERTF AC GAP+AIVHFYNSTSILQRRVV Sbjct 131 DFDFVREIITEGAIPDDVTIQVLTQCRPELIERTFAACQGAPQAIVHFYNSTSILQRRVV 190 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRA+RA VQ IA GARKCVE+AAKYP TQWRFEYSPESYTGTELEYAKQVCDAVGE+I Sbjct 191 FRADRAAVQEIAVAGARKCVEEAAKYPETQWRFEYSPESYTGTELEYAKQVCDAVGEIIR 250 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PT E PIIFNLPATVEM TPNVYADSIEWMSRNLA R+SVILSLHPHNDRGTAVAAAELG Sbjct 251 PTTENPIIFNLPATVEMATPNVYADSIEWMSRNLARRDSVILSLHPHNDRGTAVAAAELG 310 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 +AAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 311 YAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 370 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DV+DMLWQVPYLPIDP+DVGR Sbjct 371 HERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADTDVEDMLWQVPYLPIDPKDVGR 430 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQVIQKI+E GEGGEVSPKEM Sbjct 431 TYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVIQKISE---GEGGEVSPKEM 487 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAF EEYLAPV PLER++Q VDA+D+D G TSI+ATVKING +TEI+G+GNGPLAAFVH Sbjct 488 WDAFFEEYLAPVWPLERVKQRVDASDEDSGVTSISATVKINGEQTEINGTGNGPLAAFVH 547 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 ALA VGFDVAVLDY EHAMS+GDDAQAAAYVEAS Sbjct 548 ALAGVGFDVAVLDYSEHAMSSGDDAQAAAYVEAS-------------------------- 581 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 582 ------------VNGRTVWGVGIAPSITTASLRAVVSAVNRAAR 613 >gi|336460887|gb|EGO39772.1| 2-isopropylmalate synthase [Mycobacterium avium subsp. paratuberculosis S397] Length=599 Score = 1063 bits (2749), Expect = 0.0, Method: Compositional matrix adjust. Identities = 534/641 (84%), Positives = 563/641 (88%), Gaps = 44/641 (6%) Query 4 SESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTW 63 + PDA++ S +IVKPAGPP GQP+WNPQR SSMPVNRYRPFAEEVEPIRL +RTW Sbjct 2 TSHPDAFSSS---RSIVKPAGPPGPGQPAWNPQRGSSMPVNRYRPFAEEVEPIRLPDRTW 58 Query 64 PDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 123 PD+VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD Sbjct 59 PDKVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 118 Query 124 FVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRA 183 FVREII +GAIPDDVTIQVLTQCRPELIERTF AC GAP+AIVHFYNSTSILQRRVVFRA Sbjct 119 FVREIITEGAIPDDVTIQVLTQCRPELIERTFAACQGAPQAIVHFYNSTSILQRRVVFRA 178 Query 184 NRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTP 243 +RA VQ IA GARKCVE+AAKYP TQWRFEYSPESYTGTELEYAKQVCDAVGE+I PT Sbjct 179 DRAAVQEIAVAGARKCVEEAAKYPETQWRFEYSPESYTGTELEYAKQVCDAVGEIIRPTT 238 Query 244 ERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAA 303 E PIIFNLPATVEM TPNVYADSIEWMSRNLA R+SVILSLHPHNDRGTAVAAAELG+AA Sbjct 239 ENPIIFNLPATVEMATPNVYADSIEWMSRNLARRDSVILSLHPHNDRGTAVAAAELGYAA 298 Query 304 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 363 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER Sbjct 299 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 358 Query 364 HPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYE 423 HPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DV+DMLWQVPYLPIDP+DVGRTYE Sbjct 359 HPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADTDVEDMLWQVPYLPIDPKDVGRTYE 418 Query 424 AVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDA 483 AVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQVIQKI+E GEGGEVSPKEMWDA Sbjct 419 AVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVIQKISE---GEGGEVSPKEMWDA 475 Query 484 FAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALA 543 F EEYLAPV PLER++Q VDA+D+D G TSI+ATVKING +TEI+G+GNGPLAAFVHALA Sbjct 476 FFEEYLAPVWPLERVKQRVDASDEDSGVTSISATVKINGEQTEINGTGNGPLAAFVHALA 535 Query 544 DVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPG 603 VGFDVAVLDY EHAMS+GDDAQAAAYVEAS Sbjct 536 GVGFDVAVLDYSEHAMSSGDDAQAAAYVEAS----------------------------- 566 Query 604 EAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 567 ---------VNGRTVWGVGIAPSITTASLRAVVSAVNRAAR 598 >gi|254773396|ref|ZP_05214912.1| 2-isopropylmalate synthase [Mycobacterium avium subsp. avium ATCC 25291] Length=599 Score = 1062 bits (2747), Expect = 0.0, Method: Compositional matrix adjust. Identities = 532/641 (83%), Positives = 563/641 (88%), Gaps = 44/641 (6%) Query 4 SESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTW 63 + PDA++ S +IVKPAGPP GQP+WNPQR SSMPVNRYRPFAEEVEPIRL +RTW Sbjct 2 TSHPDAFSSS---RSIVKPAGPPGPGQPAWNPQRGSSMPVNRYRPFAEEVEPIRLPDRTW 58 Query 64 PDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 123 PD+VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD Sbjct 59 PDKVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 118 Query 124 FVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRA 183 FVREII +GAIPDDVTIQVLTQCRPELIERTF AC GAP+AIVHFYNSTSILQRRVVFRA Sbjct 119 FVREIITEGAIPDDVTIQVLTQCRPELIERTFAACQGAPQAIVHFYNSTSILQRRVVFRA 178 Query 184 NRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTP 243 +RA VQ IA GARKCVE+AAKYP T+WRFEYSPESYTGTELEYAKQVCDAVGE+I PTP Sbjct 179 DRAAVQEIAMAGARKCVEEAAKYPETRWRFEYSPESYTGTELEYAKQVCDAVGEIIRPTP 238 Query 244 ERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAA 303 E PIIFNLPATVEM TPNVYADSIEWMSRNLA R+S+ILSLHPHNDRGTAVAAAELG+ A Sbjct 239 ENPIIFNLPATVEMATPNVYADSIEWMSRNLARRDSIILSLHPHNDRGTAVAAAELGYVA 298 Query 304 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 363 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER Sbjct 299 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 358 Query 364 HPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYE 423 HPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DV+DMLWQVPYLPIDP+DVGRTYE Sbjct 359 HPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADTDVEDMLWQVPYLPIDPKDVGRTYE 418 Query 424 AVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDA 483 AVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQVIQKI+E GEGGEVSPKEMWDA Sbjct 419 AVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVIQKISE---GEGGEVSPKEMWDA 475 Query 484 FAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALA 543 F EEYLAPV PLER++Q VDA+D+D G TSI+ATVKING +TEI+G+GNGPLAAFVHALA Sbjct 476 FFEEYLAPVWPLERVKQRVDASDEDSGITSISATVKINGEQTEINGTGNGPLAAFVHALA 535 Query 544 DVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPG 603 VGFDVAVLDY EHAMS+GDDAQAAAYVEAS Sbjct 536 GVGFDVAVLDYSEHAMSSGDDAQAAAYVEAS----------------------------- 566 Query 604 EAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 567 ---------VNGRTVWGVGIAPSITTASLRAVVSAVNRAAR 598 >gi|118463994|ref|YP_879677.1| 2-isopropylmalate synthase [Mycobacterium avium 104] gi|118165281|gb|ABK66178.1| 2-isopropylmalate synthase [Mycobacterium avium 104] Length=599 Score = 1062 bits (2746), Expect = 0.0, Method: Compositional matrix adjust. Identities = 532/638 (84%), Positives = 563/638 (89%), Gaps = 44/638 (6%) Query 7 PDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDR 66 PDA++ S +IVKPAGPP GQP+WNPQR SSMPVNRYRPFAEEVEPIRL +RTWPD+ Sbjct 5 PDAFSSS---RSIVKPAGPPGPGQPAWNPQRGSSMPVNRYRPFAEEVEPIRLPDRTWPDK 61 Query 67 VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVR 126 VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVR Sbjct 62 VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVR 121 Query 127 EIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRA 186 EI+ +GAIPDDVTIQVLTQCRPELIERTF AC GAP+AIVHFYNSTSILQRRVVFRA+RA Sbjct 122 EIVTEGAIPDDVTIQVLTQCRPELIERTFAACQGAPQAIVHFYNSTSILQRRVVFRADRA 181 Query 187 EVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERP 246 VQ IA GARKCVE+AAKYP T+WRFEYSPESYTGTELEYAKQVCDAVGE+I PTPE P Sbjct 182 AVQEIAVAGARKCVEEAAKYPETRWRFEYSPESYTGTELEYAKQVCDAVGEIIRPTPENP 241 Query 247 IIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGAD 306 IIFNLPATVEM TPNVYADSIEWMSRNLA R+SVILSLHPHNDRGTAVAAAELG+AAGAD Sbjct 242 IIFNLPATVEMATPNVYADSIEWMSRNLARRDSVILSLHPHNDRGTAVAAAELGYAAGAD 301 Query 307 RIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPY 366 RIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPY Sbjct 302 RIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPY 361 Query 367 GGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVI 426 GGDLVYTAFSGSHQDAINKGLD M++DADAAD DV+DMLWQVPYLPIDP+DVGRTYEAVI Sbjct 362 GGDLVYTAFSGSHQDAINKGLDQMEIDADAADTDVEDMLWQVPYLPIDPKDVGRTYEAVI 421 Query 427 RVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAE 486 RVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQVIQKI+E GEGGEVSPKEMWDAF E Sbjct 422 RVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVIQKISE---GEGGEVSPKEMWDAFFE 478 Query 487 EYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVG 546 EYLAPV PLER++Q VDA+D+D G TSI+ATVKING +TEI+G+GNGPLAAFVHALA VG Sbjct 479 EYLAPVWPLERVKQRVDASDEDSGVTSISATVKINGEQTEINGTGNGPLAAFVHALAGVG 538 Query 547 FDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAG 606 FDVAVLDY EHAMS+GDDAQAAAYVEAS Sbjct 539 FDVAVLDYSEHAMSSGDDAQAAAYVEAS-------------------------------- 566 Query 607 RHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 567 ------VNGRTVWGVGIAPSITTASLRAVVSAVNRAAR 598 >gi|296166803|ref|ZP_06849222.1| 2-isopropylmalate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295897852|gb|EFG77439.1| 2-isopropylmalate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=598 Score = 1051 bits (2718), Expect = 0.0, Method: Compositional matrix adjust. Identities = 538/641 (84%), Positives = 565/641 (89%), Gaps = 44/641 (6%) Query 4 SESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTW 63 + +PDAYT +IVKPAGPP GQP WNPQR S+MPVNRYR FA+EVEPIRL +RTW Sbjct 2 TSNPDAYTSQ---RSIVKPAGPPAPGQPGWNPQRGSAMPVNRYRSFADEVEPIRLPDRTW 58 Query 64 PDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFD 123 P+RVIDRAPLWCAVDLRDGNQALIDPMSP RKRRMFDLLVRMGYKEIEVGFPSASQTDFD Sbjct 59 PERVIDRAPLWCAVDLRDGNQALIDPMSPTRKRRMFDLLVRMGYKEIEVGFPSASQTDFD 118 Query 124 FVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRA 183 FVREII GAIPDDVTIQVLTQCRPELIERTF AC GAPRAIVHFYNSTSILQRRVVFRA Sbjct 119 FVREIITDGAIPDDVTIQVLTQCRPELIERTFLACEGAPRAIVHFYNSTSILQRRVVFRA 178 Query 184 NRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTP 243 +RA VQAIATDGARKCVE+AAKYPGTQWRFEYSPESYTGTELEYA+QVCDAVGE+IAPTP Sbjct 179 DRAAVQAIATDGARKCVEEAAKYPGTQWRFEYSPESYTGTELEYARQVCDAVGEIIAPTP 238 Query 244 ERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAA 303 E PIIFNLPATVEM TPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAA Sbjct 239 ENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAA 298 Query 304 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHER 363 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQ+DFSNIDEIRRTVEYCNQLPV ER Sbjct 299 GADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQVDFSNIDEIRRTVEYCNQLPVPER 358 Query 364 HPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYE 423 HPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DVDDMLWQVPYLPIDP+DVGRTYE Sbjct 359 HPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADADVDDMLWQVPYLPIDPKDVGRTYE 418 Query 424 AVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDA 483 AVIRVNSQSGKGGVAYIMK+DHGL+LPRRLQIEFSQ IQKI E GEGGEVSPKEMWDA Sbjct 419 AVIRVNSQSGKGGVAYIMKSDHGLALPRRLQIEFSQAIQKITE---GEGGEVSPKEMWDA 475 Query 484 FAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALA 543 F EEYLAPV PLER++Q V+A+++D GTT+I ATVK+NGVETE+SG+GNGPLAAFVHAL Sbjct 476 FYEEYLAPVWPLERMKQRVEASEEDSGTTTIAATVKVNGVETEVSGAGNGPLAAFVHALG 535 Query 544 DVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPG 603 DVGFDVAVLDY EHAMSAGDDAQAAAYVEAS Sbjct 536 DVGFDVAVLDYSEHAMSAGDDAQAAAYVEAS----------------------------- 566 Query 604 EAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 567 ---------VNGRTVWGVGIAPSITTASLRAVVSAVNRAAR 598 >gi|161611210|ref|NP_959246.2| 2-isopropylmalate synthase [Mycobacterium avium subsp. paratuberculosis K-10] Length=564 Score = 1041 bits (2692), Expect = 0.0, Method: Compositional matrix adjust. Identities = 512/604 (85%), Positives = 536/604 (89%), Gaps = 41/604 (6%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPVNRYRPFAEEVEPIRL +RTWPD+VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPVNRYRPFAEEVEPIRLPDRTWPDKVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREII +GAIPDDVTIQVLTQCRPELIERTF AC G Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIITEGAIPDDVTIQVLTQCRPELIERTFAACQG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 AP+AIVHFYNSTSILQRRVVFRA+RA VQ IA GARKCVE+AAKYP TQWRFEYSPESY Sbjct 121 APQAIVHFYNSTSILQRRVVFRADRAAVQEIAVAGARKCVEEAAKYPETQWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAVGE+I PT E PIIFNLPATVEM TPNVYADSIEWMSRNLA R+SV Sbjct 181 TGTELEYAKQVCDAVGEIIRPTTENPIIFNLPATVEMATPNVYADSIEWMSRNLARRDSV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELG+AAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGYAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD D Sbjct 301 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADTD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 V+DMLWQVPYLPIDP+DVGRTYEAVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQV Sbjct 361 VEDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQV 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQKI+E GEGGEVSPKEMWDAF EEYLAPV PLER++Q VDA+D+D G TSI+ATVKI Sbjct 421 IQKISE---GEGGEVSPKEMWDAFFEEYLAPVWPLERVKQRVDASDEDSGVTSISATVKI 477 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 NG +TEI+G+GNGPLAAFVHALA VGFDVAVLDY EHAMS+GDDAQAAAYVEAS Sbjct 478 NGEQTEINGTGNGPLAAFVHALAGVGFDVAVLDYSEHAMSSGDDAQAAAYVEAS------ 531 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 V +TVWGVGIAPSITTASLRAVVSAVN Sbjct 532 --------------------------------VNGRTVWGVGIAPSITTASLRAVVSAVN 559 Query 641 RAAR 644 RAAR Sbjct 560 RAAR 563 >gi|240172823|ref|ZP_04751482.1| 2-isopropylmalate synthase [Mycobacterium kansasii ATCC 12478] Length=563 Score = 1030 bits (2662), Expect = 0.0, Method: Compositional matrix adjust. Identities = 513/604 (85%), Positives = 540/604 (90%), Gaps = 41/604 (6%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPV+RYRPFAEEVEPIRL +R+WPDRVI APLWCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPVHRYRPFAEEVEPIRLADRSWPDRVITHAPLWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTF+AC G Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFEACQG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 A +AIVHFYNSTSILQRRVVF+A+RA VQAIA DGARKCVE+AAKYPGTQWRFEYSPESY Sbjct 121 AAKAIVHFYNSTSILQRRVVFKADRAAVQAIAVDGARKCVEEAAKYPGTQWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAVGE+I PTP+ PIIFNLPATVEM TPNVYADSIEWMS NLANR+SV Sbjct 181 TGTELEYAKQVCDAVGEIIRPTPDNPIIFNLPATVEMATPNVYADSIEWMSHNLANRDSV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELG+ AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMK DADAAD D Sbjct 301 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKFDADAADTD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMK DHGL LPRRLQIEFSQV Sbjct 361 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLVLPRRLQIEFSQV 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQKI+E GEGGEVSPKEMWDAFA+EYLAPVRPLER++QH+D +++ GTTSITATVKI Sbjct 421 IQKISE---GEGGEVSPKEMWDAFAQEYLAPVRPLERVKQHIDVVEEESGTTSITATVKI 477 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 +GVETE++G+GNGPLAAFVHAL DVGFDVAVLDY EHAMSAGDDAQAAAYVEAS Sbjct 478 DGVETEVTGTGNGPLAAFVHALGDVGFDVAVLDYSEHAMSAGDDAQAAAYVEAS------ 531 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 V +TVWGVGIAPSITTASLRAVVSA+N Sbjct 532 --------------------------------VGGRTVWGVGIAPSITTASLRAVVSAIN 559 Query 641 RAAR 644 RA+R Sbjct 560 RASR 563 >gi|118619454|ref|YP_907786.1| 2-isopropylmalate synthase [Mycobacterium ulcerans Agy99] gi|166224542|sp|A0PVE6.1|LEU1_MYCUA RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase gi|118571564|gb|ABL06315.1| 2-isopropylmalate synthase LeuA [Mycobacterium ulcerans Agy99] Length=566 Score = 1027 bits (2656), Expect = 0.0, Method: Compositional matrix adjust. Identities = 516/604 (86%), Positives = 539/604 (90%), Gaps = 38/604 (6%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPVNRYRPFAEEVE IR+ +RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPVNRYRPFAEEVEHIRVTDRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREII +GAIPDDVTIQVLTQCRPELIERTF+AC+G Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIITEGAIPDDVTIQVLTQCRPELIERTFEACAG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 A + IVHFYNSTSILQRRVVFRA+RA V+AIATDGAR+CVE+AAKYP TQWRFEYSPESY Sbjct 121 ASKVIVHFYNSTSILQRRVVFRADRAAVEAIATDGARRCVEEAAKYPDTQWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAV EVI PTPE PIIFNLPATVEM TPNVYADSIEWMSRNLANRESV Sbjct 181 TGTELEYAKQVCDAVAEVIQPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCL TLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLATLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPV ERHPYGGDLVYTAFSGSHQDAINKGLDAM+ DADAAD D Sbjct 301 DFSNIDEIRRTVEYCNQLPVPERHPYGGDLVYTAFSGSHQDAINKGLDAMEFDADAADSD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 +DDMLWQVPYLPIDP+DVGRTYEAVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFS+ Sbjct 361 MDDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSRA 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQ+IAEG+AGEGGEVSPKEMWDAFAEEYLAPVRPLERI+Q V AA++DGGTTSI ATVKI Sbjct 421 IQEIAEGSAGEGGEVSPKEMWDAFAEEYLAPVRPLERIKQRVIAAEEDGGTTSIDATVKI 480 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 +G E EISGSGNGPLAAFVHAL VGFDVAVLDY EHAMSAGDDAQAAAYVEAS Sbjct 481 DGKEAEISGSGNGPLAAFVHALGTVGFDVAVLDYSEHAMSAGDDAQAAAYVEAS------ 534 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 V KTVWGVGIAPSITTASLRAVVSA+N Sbjct 535 --------------------------------VAGKTVWGVGIAPSITTASLRAVVSAIN 562 Query 641 RAAR 644 RA+R Sbjct 563 RASR 566 >gi|108801861|ref|YP_642058.1| 2-isopropylmalate synthase [Mycobacterium sp. MCS] gi|119871014|ref|YP_940966.1| 2-isopropylmalate synthase [Mycobacterium sp. KMS] gi|126437829|ref|YP_001073520.1| 2-isopropylmalate synthase [Mycobacterium sp. JLS] gi|108772280|gb|ABG11002.1| 2-isopropylmalate synthase [Mycobacterium sp. MCS] gi|119697103|gb|ABL94176.1| 2-isopropylmalate synthase [Mycobacterium sp. KMS] gi|126237629|gb|ABO01030.1| 2-isopropylmalate synthase [Mycobacterium sp. JLS] Length=601 Score = 1019 bits (2634), Expect = 0.0, Method: Compositional matrix adjust. Identities = 500/644 (78%), Positives = 544/644 (85%), Gaps = 44/644 (6%) Query 1 VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 + T ES DA++ I P+GPP GQP+WN QRAS+MPV+RYR FAEEVEP+ L + Sbjct 1 MNTPESTDAFS---SVRAITTPSGPPHPGQPAWNTQRASAMPVSRYRSFAEEVEPVTLPD 57 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPD+V+D AP+WCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 58 RTWPDKVVDTAPMWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 117 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREIIEQGAIPDDVTIQVLTQCRPELI RTF+AC GAPRAIVHFYNSTSILQRRVV Sbjct 118 DFDFVREIIEQGAIPDDVTIQVLTQCRPELITRTFEACKGAPRAIVHFYNSTSILQRRVV 177 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRA+R V+ IA DGAR CVE+AAK+P T WRFEYSPESYTGTELEYA VC+AV +++ Sbjct 178 FRADREAVKQIAVDGARMCVEEAAKHPDTLWRFEYSPESYTGTELEYAVDVCNAVADIVK 237 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTPE P+I NLPATVEM TPNVYADSIEWM+R+L+ R+S+ILSLHPHNDRGTAVAAAELG Sbjct 238 PTPEVPLIVNLPATVEMATPNVYADSIEWMNRHLSPRDSIILSLHPHNDRGTAVAAAELG 297 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 + AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV Sbjct 298 YQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 357 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMK+ AD AD DVDD+LWQVPYLPIDP+DVGR Sbjct 358 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKVAADEADSDVDDILWQVPYLPIDPKDVGR 417 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMK DHGL LPRRLQIEFSQ IQKI T GEGGEVSPKEM Sbjct 418 TYEAVIRVNSQSGKGGVAYIMKADHGLVLPRRLQIEFSQAIQKI---TDGEGGEVSPKEM 474 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WD FAEEYL+PVRPLER+RQ VDAA+ DGGT +ITA VK++GVE EI G+GNGPLAAF Sbjct 475 WDVFAEEYLSPVRPLERMRQKVDAAEVDGGTDTITAVVKVDGVEREIVGAGNGPLAAFCD 534 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 AL +GFD++VLDY EHA+SAG++AQAAAYVEAS Sbjct 535 ALGAIGFDISVLDYSEHALSAGEEAQAAAYVEAS-------------------------- 568 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V KTVWGVGIA SITTASLRAVVSAVNRAAR Sbjct 569 ------------VGGKTVWGVGIATSITTASLRAVVSAVNRAAR 600 >gi|221230726|ref|YP_002504142.1| 2-isopropylmalate synthase [Mycobacterium leprae Br4923] gi|18202752|sp|Q9CB76.1|LEU1_MYCLE RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase gi|13093942|emb|CAC31840.1| 2-isopropylmalate synthase [Mycobacterium leprae] gi|219933833|emb|CAR72422.1| 2-isopropylmalate synthase [Mycobacterium leprae Br4923] Length=607 Score = 1013 bits (2620), Expect = 0.0, Method: Compositional matrix adjust. Identities = 516/642 (81%), Positives = 545/642 (85%), Gaps = 45/642 (7%) Query 2 TTSESP-DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN 60 + S+ P DAY A +I KP GPP GQP WNPQRA+SMPV RYRPFA+EVEPIRL + Sbjct 7 SLSQDPADAYK---SAPSITKPMGPPSPGQPQWNPQRATSMPVFRYRPFAKEVEPIRLVD 63 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPDRVID APLWCAVDLRDGNQALIDPMSP KRRMFDLLVRMGYKEIEVGFPSASQT Sbjct 64 RTWPDRVIDCAPLWCAVDLRDGNQALIDPMSPICKRRMFDLLVRMGYKEIEVGFPSASQT 123 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 DFDFVREII G IPDDVTIQVLTQCRPELIERTF+AC A R IVHFYNSTSILQRRVV Sbjct 124 DFDFVREIITDGTIPDDVTIQVLTQCRPELIERTFEACENASRVIVHFYNSTSILQRRVV 183 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRA++A V+AIATDGARKCVE+A KYPGT WRFEYSPESYTGTELEYAKQVCDAVGEVI Sbjct 184 FRADQATVKAIATDGARKCVEEAFKYPGTHWRFEYSPESYTGTELEYAKQVCDAVGEVIQ 243 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTP+ PIIFNLPATVEM TPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG Sbjct 244 PTPDNPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 303 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 + AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCN+L V Sbjct 304 YHAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNKLRV 363 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DVDD+LWQVPYLPIDPRDVGR Sbjct 364 HERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADSDVDDILWQVPYLPIDPRDVGR 423 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMK DHGL LPRRLQIEFS+ IQKI+E GEGGE++P EM Sbjct 424 TYEAVIRVNSQSGKGGVAYIMKADHGLELPRRLQIEFSRAIQKISE---GEGGEITPTEM 480 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WD F EEYL+PV+PLERI+Q V+AA++DGG+TSI ATVKING ETEISG GNGPLAAF+ Sbjct 481 WDVFFEEYLSPVQPLERIKQRVNAAEEDGGSTSIAATVKINGEETEISGVGNGPLAAFID 540 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 AL VG VAVLDY EHAM+AGDDAQAAAYVEAS Sbjct 541 ALGHVGLQVAVLDYSEHAMNAGDDAQAAAYVEAS-------------------------- 574 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRA 642 V T WGVGIAPSITTASLRAVVSAVNRA Sbjct 575 ------------VHGHTAWGVGIAPSITTASLRAVVSAVNRA 604 >gi|54013780|dbj|BAD55150.1| putative 2-isopropylmalate synthase [Nocardia farcinica IFM 10152] Length=597 Score = 993 bits (2568), Expect = 0.0, Method: Compositional matrix adjust. Identities = 484/635 (77%), Positives = 529/635 (84%), Gaps = 43/635 (6%) Query 8 DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV 67 DAY G+ I P+ P QP+WN Q+ SSMP RYRPFAEEVEP+ L +RTWPD+V Sbjct 5 DAYVS--GSRHITAPSKPAPADQPAWNAQKNSSMPAYRYRPFAEEVEPVTLPDRTWPDKV 62 Query 68 IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 127 IDRAP WCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTD+DFVRE Sbjct 63 IDRAPGWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDYDFVRE 122 Query 128 IIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAE 187 IIE AIPDDVTIQVLTQCRPELIERTF+AC+GA IVHFYNSTSILQRRVVFRA+R + Sbjct 123 IIEDNAIPDDVTIQVLTQCRPELIERTFEACAGAANVIVHFYNSTSILQRRVVFRADREQ 182 Query 188 VQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPI 247 V+ IATD A+ C+E +YP T WR+EYSPESYTGTELEYA++VCDAV E+IAPTPE+P+ Sbjct 183 VKKIATDAAKLCLEVEKRYPDTNWRYEYSPESYTGTELEYAREVCDAVSEIIAPTPEKPL 242 Query 248 IFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADR 307 I NLPATVEM TPNVYADSIEWMSRNLA RES++LSLHPHNDRGTAVAAAELG+ AGADR Sbjct 243 IINLPATVEMATPNVYADSIEWMSRNLARRESIVLSLHPHNDRGTAVAAAELGYQAGADR 302 Query 308 IEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 367 IEGCLFGNGERTGNVCLVTLG+N+FSRG+DPQIDFS+IDEIRRTVEYCNQLPVHERHPYG Sbjct 303 IEGCLFGNGERTGNVCLVTLGMNMFSRGIDPQIDFSDIDEIRRTVEYCNQLPVHERHPYG 362 Query 368 GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIR 427 GDLVYTAFSGSHQDAINKGLDAMK ADA + DV D++W+VPYLPIDP+DVGRTYEAVIR Sbjct 363 GDLVYTAFSGSHQDAINKGLDAMKAAADAQNADVSDIVWEVPYLPIDPKDVGRTYEAVIR 422 Query 428 VNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEE 487 VNSQSGKGGVAYIMKTDHGL LPRRLQIEFSQV+QKI T GEGGEV+PKEMWD F EE Sbjct 423 VNSQSGKGGVAYIMKTDHGLVLPRRLQIEFSQVVQKI---TDGEGGEVTPKEMWDVFHEE 479 Query 488 YLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGF 547 YLAP+RPLERIRQ V AA+ DGG SITA VK++GVE EI+G GNGPLAAFV A+A VG+ Sbjct 480 YLAPIRPLERIRQKVTAAETDGGVDSITAVVKVDGVEQEITGQGNGPLAAFVDAIATVGY 539 Query 548 DVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGR 607 DV VLDY EHAMSAGDDAQAAAYVE + Sbjct 540 DVRVLDYSEHAMSAGDDAQAAAYVECA--------------------------------- 566 Query 608 HASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRA 642 + K VWGVGIA SITTASLRAVVSAVNRA Sbjct 567 -----IGDKVVWGVGIATSITTASLRAVVSAVNRA 596 >gi|145221885|ref|YP_001132563.1| 2-isopropylmalate synthase [Mycobacterium gilvum PYR-GCK] gi|315446379|ref|YP_004079258.1| 2-isopropylmalate synthase [Mycobacterium sp. Spyr1] gi|145214371|gb|ABP43775.1| 2-isopropylmalate synthase [Mycobacterium gilvum PYR-GCK] gi|315264682|gb|ADU01424.1| 2-isopropylmalate synthase [Mycobacterium sp. Spyr1] Length=606 Score = 989 bits (2558), Expect = 0.0, Method: Compositional matrix adjust. Identities = 505/639 (80%), Positives = 538/639 (85%), Gaps = 44/639 (6%) Query 6 SPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPD 65 S DA++ TIV PAG P GQPSWN QRASSMPVNRYR F +EVEPIRL +RTWP+ Sbjct 8 SADAFS---SVRTIVTPAGKPNPGQPSWNTQRASSMPVNRYRSFDDEVEPIRLPDRTWPE 64 Query 66 RVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFV 125 + I AP+W AVDLRDGNQALIDPMSP RKRRMFDLLVRMGYKEIEVGFPSASQTDFDFV Sbjct 65 KAITTAPMWAAVDLRDGNQALIDPMSPQRKRRMFDLLVRMGYKEIEVGFPSASQTDFDFV 124 Query 126 REIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANR 185 REIIEQGAIPDDVTIQVLTQCRPELIERTF AC GAPRAIVHFYNSTSILQRRVVFRA+R Sbjct 125 REIIEQGAIPDDVTIQVLTQCRPELIERTFLACQGAPRAIVHFYNSTSILQRRVVFRADR 184 Query 186 AEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPER 245 V+ IATDGAR CVE+A KYPGTQWR+EYSPESYTGTELEYA +VC+AV EV+ PTPE Sbjct 185 DAVKQIATDGARMCVEEAKKYPGTQWRYEYSPESYTGTELEYAVEVCNAVAEVVQPTPEW 244 Query 246 PIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGA 305 P+I NLPATVEM TPNVYADSIEWM R+L R+S+ILSLHPHNDRGTAVAAAELG+AAGA Sbjct 245 PLIVNLPATVEMATPNVYADSIEWMHRHLTPRDSIILSLHPHNDRGTAVAAAELGYAAGA 304 Query 306 DRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHP 365 DRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQL V ERHP Sbjct 305 DRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLAVPERHP 364 Query 366 YGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAV 425 YGGDLVYTAFSGSHQDAINKGLDAMK DADAAD DVDD+LWQVPYLPIDP+DVGRTYEAV Sbjct 365 YGGDLVYTAFSGSHQDAINKGLDAMKFDADAADKDVDDLLWQVPYLPIDPKDVGRTYEAV 424 Query 426 IRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFA 485 IRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQVIQ+I T GEGGEVSPKEMWDAF Sbjct 425 IRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVIQQI---TDGEGGEVSPKEMWDAFY 481 Query 486 EEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADV 545 EEYLAPV PLERIRQ VDAA+ DGGT +ITA VKI+G E EI G+GNGPLAAFV A+ V Sbjct 482 EEYLAPVTPLERIRQKVDAAEVDGGTDTITAVVKIDGEEREIVGAGNGPLAAFVDAVGAV 541 Query 546 GFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEA 605 GF+V VLDY EHAMSAG++AQAAAYVEA Sbjct 542 GFNVNVLDYSEHAMSAGEEAQAAAYVEAE------------------------------- 570 Query 606 GRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 + +TVWGVGIA SITTASLRAVVSAVNRAAR Sbjct 571 -------IDGRTVWGVGIATSITTASLRAVVSAVNRAAR 602 >gi|226363561|ref|YP_002781343.1| 2-isopropylmalate synthase [Rhodococcus opacus B4] gi|226242050|dbj|BAH52398.1| 2-isopropylmalate synthase [Rhodococcus opacus B4] Length=602 Score = 987 bits (2551), Expect = 0.0, Method: Compositional matrix adjust. Identities = 487/635 (77%), Positives = 529/635 (84%), Gaps = 38/635 (5%) Query 8 DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV 67 DA+T G TI P+ P QP WN Q+ SSMP RYR F+EEVEP+ L +RTWPD++ Sbjct 5 DAFTS--GTRTITPPSKPAPSDQPIWNTQKNSSMPTFRYRSFSEEVEPVSLPDRTWPDKI 62 Query 68 IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 127 IDRAP WCAVDLRDGNQALIDPMSPARKRRMF+LLVRMGYKEIEVGFPSASQTDFDFVRE Sbjct 63 IDRAPQWCAVDLRDGNQALIDPMSPARKRRMFELLVRMGYKEIEVGFPSASQTDFDFVRE 122 Query 128 IIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAE 187 IIE GAIPDDVTIQVLTQ RPELI+RTF+AC GA + IVHFYNSTS+LQRRVVF+A+R Sbjct 123 IIEDGAIPDDVTIQVLTQSRPELIKRTFEACEGANKVIVHFYNSTSVLQRRVVFKADREV 182 Query 188 VQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPI 247 ++ IATD A +E+A KYP TQWR+EYSPESYTGTELEYAK+VCDAV EV+ PTP+ P+ Sbjct 183 IKKIATDAATLALEEAKKYPDTQWRWEYSPESYTGTELEYAKEVCDAVTEVLQPTPQNPV 242 Query 248 IFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADR 307 I NLPATVEM TPNVYADSIEWM RNLA R+SVILSLHPHNDRGT VAAAELG+ AGADR Sbjct 243 ILNLPATVEMATPNVYADSIEWMHRNLARRDSVILSLHPHNDRGTGVAAAELGYQAGADR 302 Query 308 IEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 367 IEGCLFGNGERTGNVCLVTLGLN+F+RGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG Sbjct 303 IEGCLFGNGERTGNVCLVTLGLNMFTRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 362 Query 368 GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIR 427 GDLVYTAFSGSHQDAINKGLDAMK DAD+ D DVDD+LW VPYLPIDP+DVGRTYEAVIR Sbjct 363 GDLVYTAFSGSHQDAINKGLDAMKFDADSQDADVDDILWAVPYLPIDPKDVGRTYEAVIR 422 Query 428 VNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEE 487 VNSQSGKGGVAYIMK DHGL LPRRLQIEFSQ +Q+I T GEGGEVSPKEMWD F EE Sbjct 423 VNSQSGKGGVAYIMKADHGLVLPRRLQIEFSQAVQRI---TDGEGGEVSPKEMWDVFHEE 479 Query 488 YLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGF 547 YLAP+ PLER++Q V AA++DGGT SITATVK+NG E EISGSGNGPLAAFV ALA + F Sbjct 480 YLAPITPLERMKQKVTAAEEDGGTDSITATVKVNGKEHEISGSGNGPLAAFVDALATIDF 539 Query 548 DVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGR 607 DV VLDY EHAMSAGDDAQAAAYVE +VT A D GR Sbjct 540 DVRVLDYSEHAMSAGDDAQAAAYVECAVT-------------APD-------------GR 573 Query 608 HASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRA 642 + VWGVGIA SITTASLRAVVSAVNRA Sbjct 574 NT-------VVWGVGIATSITTASLRAVVSAVNRA 601 >gi|169627441|ref|YP_001701090.1| 2-isopropylmalate synthase [Mycobacterium abscessus ATCC 19977] gi|169239408|emb|CAM60436.1| Probable 2-isopropylmalate synthase (LeuA) [Mycobacterium abscessus] Length=607 Score = 984 bits (2544), Expect = 0.0, Method: Compositional matrix adjust. Identities = 485/642 (76%), Positives = 537/642 (84%), Gaps = 37/642 (5%) Query 3 TSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRT 62 TS S D + ++ ++V P GP QP+WN Q+ SSMPV+RYR F +EVE I L +RT Sbjct 2 TSFSSDEF--NYTPRSVVTPNGPIPADQPAWNTQKNSSMPVHRYRSFTDEVEKIELPDRT 59 Query 63 WPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDF 122 WPD+VI RAP W AVDLRDGNQALIDPMSPARKRRMFDL +RMG+KEIEVGFPSASQTDF Sbjct 60 WPDKVITRAPQWGAVDLRDGNQALIDPMSPARKRRMFDLQIRMGFKEIEVGFPSASQTDF 119 Query 123 DFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFR 182 DF+RE+I + AIPDDVTIQVLTQCRPELIERTF AC GA + IVHFYNSTSILQRRVVFR Sbjct 120 DFIRELITENAIPDDVTIQVLTQCRPELIERTFLACEGASKVIVHFYNSTSILQRRVVFR 179 Query 183 ANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPT 242 ++ ++ IATDGA KCVE+AAKYP T WRF+YSPESYTGTEL+YA +VC+AVG+++ PT Sbjct 180 EDKDAIKKIATDGAHKCVEEAAKYPDTHWRFQYSPESYTGTELQYALEVCNAVGDIVEPT 239 Query 243 PERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFA 302 P+ PIIFNLP+TVEMTTPNVYADSIEWMSRNLA R+SVILSLHPHNDRGTAVAAAELGF Sbjct 240 PDNPIIFNLPSTVEMTTPNVYADSIEWMSRNLARRDSVILSLHPHNDRGTAVAAAELGFQ 299 Query 303 AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHE 362 AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIR TVEYCNQL V E Sbjct 300 AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRHTVEYCNQLKVPE 359 Query 363 RHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTY 422 RHPYGGDLVYTAFSGSHQDAINKGLD MK DAD AD DVDD+LWQVPYLPIDP+DVGR Y Sbjct 360 RHPYGGDLVYTAFSGSHQDAINKGLDQMKRDADEADSDVDDILWQVPYLPIDPKDVGRNY 419 Query 423 EAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWD 482 EAVIRVNSQSGKGGVAYIMK+DHGL LPRRLQIEF+Q IQ+I T GEGGEV+PKE+WD Sbjct 420 EAVIRVNSQSGKGGVAYIMKSDHGLVLPRRLQIEFAQSIQRI---TDGEGGEVNPKEIWD 476 Query 483 AFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHAL 542 FAEEYLAP+ PLERIRQ V A+++DGGT SI A VKI+G ETE++G+GNGPLAAFV AL Sbjct 477 VFAEEYLAPITPLERIRQKVTASEEDGGTDSIAAVVKIDGKETEVNGTGNGPLAAFVDAL 536 Query 543 ADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQP 602 + VG+ V VLDY EHA+SAGDDAQAAAYVEA T+ SP Sbjct 537 STVGYTVNVLDYSEHALSAGDDAQAAAYVEA---------------------TVVSPGG- 574 Query 603 GEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 GEA +TVWGVGIAPSITTASLRAVVSAVNRAAR Sbjct 575 GEA----------QTVWGVGIAPSITTASLRAVVSAVNRAAR 606 >gi|111021202|ref|YP_704174.1| 2-isopropylmalate synthase [Rhodococcus jostii RHA1] gi|110820732|gb|ABG96016.1| 2-isopropylmalate synthase [Rhodococcus jostii RHA1] Length=602 Score = 984 bits (2543), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/635 (77%), Positives = 528/635 (84%), Gaps = 38/635 (5%) Query 8 DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV 67 DA+T G TI P+ P QP WN Q+ SSMP RYR F+EEVEP+ L +R+WPD+V Sbjct 5 DAFTS--GTRTITPPSKPAPSDQPEWNTQKNSSMPTFRYRSFSEEVEPVSLPDRSWPDKV 62 Query 68 IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 127 IDRAP WCAVDLRDGNQALIDPMSPARKRRMF+LLVRMGYKEIEVGFPSASQTDFDFVRE Sbjct 63 IDRAPQWCAVDLRDGNQALIDPMSPARKRRMFELLVRMGYKEIEVGFPSASQTDFDFVRE 122 Query 128 IIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAE 187 IIE GAIPDDVTIQVLTQ RPELI+RTF+AC GA + IVHFYNSTSILQRRVVF+A R Sbjct 123 IIEDGAIPDDVTIQVLTQSRPELIKRTFEACEGANKVIVHFYNSTSILQRRVVFKAERDV 182 Query 188 VQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPI 247 ++ IATD A +E+A +YP TQWR+EYSPESYTGTELEYAK+VCDAV EV+ PTPE P+ Sbjct 183 IKKIATDAATLALEEAKQYPDTQWRWEYSPESYTGTELEYAKEVCDAVTEVLQPTPENPV 242 Query 248 IFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADR 307 I NLPATVEM TPNVYADSIEWM RNLA R+SVILSLHPHNDRGT VAAAELG+ AGADR Sbjct 243 ILNLPATVEMATPNVYADSIEWMHRNLARRDSVILSLHPHNDRGTGVAAAELGYQAGADR 302 Query 308 IEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 367 IEGCLFGNGERTGNVCLVTLGLN+F+RGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG Sbjct 303 IEGCLFGNGERTGNVCLVTLGLNMFTRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 362 Query 368 GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIR 427 GDLVYTAFSGSHQDAINKGLDAMK DAD+ D DVDD+LW VPYLPIDP+DVGRTYEAVIR Sbjct 363 GDLVYTAFSGSHQDAINKGLDAMKFDADSQDADVDDILWAVPYLPIDPKDVGRTYEAVIR 422 Query 428 VNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEE 487 VNSQSGKGGVAYIMK DHGL LPRRLQIEFSQ +Q+I T GEGGEVSPKEMWD F EE Sbjct 423 VNSQSGKGGVAYIMKADHGLVLPRRLQIEFSQAVQRI---TDGEGGEVSPKEMWDVFHEE 479 Query 488 YLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGF 547 YLAP+ PLER++Q V A+++DGGT SITATVK++G E EISGSGNGPLAAFV ALA + F Sbjct 480 YLAPITPLERMKQKVTASEEDGGTDSITATVKVDGKEHEISGSGNGPLAAFVDALATIDF 539 Query 548 DVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGR 607 DV VLDY EHAMSAGDDAQAAAYVE +VT A D GR Sbjct 540 DVRVLDYSEHAMSAGDDAQAAAYVECAVT-------------APD-------------GR 573 Query 608 HASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRA 642 + VWGVGIA SITTASLRAVVSAVNRA Sbjct 574 NT-------VVWGVGIATSITTASLRAVVSAVNRA 601 >gi|333992633|ref|YP_004525247.1| 2-isopropylmalate synthase LeuA [Mycobacterium sp. JDM601] gi|333488601|gb|AEF37993.1| 2-isopropylmalate synthase LeuA [Mycobacterium sp. JDM601] Length=604 Score = 982 bits (2538), Expect = 0.0, Method: Compositional matrix adjust. Identities = 499/639 (79%), Positives = 539/639 (85%), Gaps = 44/639 (6%) Query 6 SPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPD 65 SPDA+T I KP GPP GQP WN QR S+MP++RYR FA+EVE I L +RTWPD Sbjct 8 SPDAFTS---GRRITKPVGPPNPGQPGWNTQRGSAMPISRYRSFADEVENIVLPDRTWPD 64 Query 66 RVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFV 125 RVI+RAP+WCAVDLRDGNQALIDPMSPARKRRMFDLLV MGYKEIEVGFPSASQTD+DFV Sbjct 65 RVIERAPMWCAVDLRDGNQALIDPMSPARKRRMFDLLVAMGYKEIEVGFPSASQTDYDFV 124 Query 126 REIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANR 185 REIIE GA+PDDVT+QVLTQCR ELIERTF+AC GAP IVHFYNSTSILQRRVVFRA+R Sbjct 125 REIIEAGAVPDDVTLQVLTQCRDELIERTFEACDGAPNVIVHFYNSTSILQRRVVFRADR 184 Query 186 AEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPER 245 A VQ IA GARKC+E+AAKYPGT+WR+EYSPESYTGTELEYAK VCDAVG+VI P+P+ Sbjct 185 AAVQEIAVAGARKCLEEAAKYPGTRWRYEYSPESYTGTELEYAKAVCDAVGDVIQPSPDS 244 Query 246 PIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGA 305 PIIFNLPATVEM TPNVYADSIEWM RNL R+SVILSLHPHNDRGTAVAAAELG+ AGA Sbjct 245 PIIFNLPATVEMATPNVYADSIEWMHRNLKRRDSVILSLHPHNDRGTAVAAAELGYQAGA 304 Query 306 DRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHP 365 DRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQL V ERHP Sbjct 305 DRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLGVPERHP 364 Query 366 YGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAV 425 YGGDLVYTAFSGSHQDAINKGLD MK+DADAAD DVDDMLWQVPYLPIDPRDVGRTYEAV Sbjct 365 YGGDLVYTAFSGSHQDAINKGLDQMKVDADAADSDVDDMLWQVPYLPIDPRDVGRTYEAV 424 Query 426 IRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFA 485 IRVNSQSGKGGVAY+MKTDHGL LPRRLQIEFS+VIQ++ T GEGGEV+PKEMWDAFA Sbjct 425 IRVNSQSGKGGVAYVMKTDHGLVLPRRLQIEFSKVIQQL---TDGEGGEVTPKEMWDAFA 481 Query 486 EEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADV 545 EEYL P+RPLER+ Q + AA+ D GT I ATV ++GVETEI+G+GNGPLAAFV AL+DV Sbjct 482 EEYLNPIRPLERMHQRLIAAETDDGTDRIEATVLVDGVETEIAGAGNGPLAAFVDALSDV 541 Query 546 GFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEA 605 G V VLDY EHAMSAG++AQAAAYVEAS+ G H Sbjct 542 GIHVNVLDYSEHAMSAGEEAQAAAYVEASL-----------GDH---------------- 574 Query 606 GRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 TVWGVGIA SITTASLRAVVSAVNRAAR Sbjct 575 -----------TVWGVGIASSITTASLRAVVSAVNRAAR 602 >gi|161723262|ref|NP_302512.2| 2-isopropylmalate synthase [Mycobacterium leprae TN] Length=564 Score = 976 bits (2524), Expect = 0.0, Method: Compositional matrix adjust. Identities = 494/602 (83%), Positives = 519/602 (87%), Gaps = 41/602 (6%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MPV RYRPFA+EVEPIRL +RTWPDRVID APLWCAVDLRDGNQALIDPMSP KRRMFD Sbjct 1 MPVFRYRPFAKEVEPIRLVDRTWPDRVIDCAPLWCAVDLRDGNQALIDPMSPICKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREII G IPDDVTIQVLTQCRPELIERTF+AC Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIITDGTIPDDVTIQVLTQCRPELIERTFEACEN 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 A R IVHFYNSTSILQRRVVFRA++A V+AIATDGARKCVE+A KYPGT WRFEYSPESY Sbjct 121 ASRVIVHFYNSTSILQRRVVFRADQATVKAIATDGARKCVEEAFKYPGTHWRFEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYAKQVCDAVGEVI PTP+ PIIFNLPATVEM TPNVYADSIEWMSRNLANRESV Sbjct 181 TGTELEYAKQVCDAVGEVIQPTPDNPIIFNLPATVEMATPNVYADSIEWMSRNLANRESV 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGTAVAAAELG+ AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI Sbjct 241 ILSLHPHNDRGTAVAAAELGYHAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCN+L VHERHPYGGDLVYTAFSGSHQDAINKGLD MK+DADAAD D Sbjct 301 DFSNIDEIRRTVEYCNKLRVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADSD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 VDD+LWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMK DHGL LPRRLQIEFS+ Sbjct 361 VDDILWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLELPRRLQIEFSRA 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 IQKI+E GEGGE++P EMWD F EEYL+PV+PLERI+Q V+AA++DGG+TSI ATVKI Sbjct 421 IQKISE---GEGGEITPTEMWDVFFEEYLSPVQPLERIKQRVNAAEEDGGSTSIAATVKI 477 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 NG ETEISG GNGPLAAF+ AL VG VAVLDY EHAM+AGDDAQAAAYVEAS Sbjct 478 NGEETEISGVGNGPLAAFIDALGHVGLQVAVLDYSEHAMNAGDDAQAAAYVEAS------ 531 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 V T WGVGIAPSITTASLRAVVSAVN Sbjct 532 --------------------------------VHGHTAWGVGIAPSITTASLRAVVSAVN 559 Query 641 RA 642 RA Sbjct 560 RA 561 >gi|226303900|ref|YP_002763858.1| 2-isopropylmalate synthase [Rhodococcus erythropolis PR4] gi|226183015|dbj|BAH31119.1| 2-isopropylmalate synthase [Rhodococcus erythropolis PR4] Length=602 Score = 974 bits (2519), Expect = 0.0, Method: Compositional matrix adjust. Identities = 479/636 (76%), Positives = 521/636 (82%), Gaps = 38/636 (5%) Query 8 DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV 67 DA+T G TI P P QP+WN Q+ SSMP RYRPFAEEVE + L +RTWPD++ Sbjct 5 DAFTT--GTRTITPPTKPAPSDQPAWNTQKNSSMPTFRYRPFAEEVETVTLPDRTWPDKI 62 Query 68 IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 127 IDRAP WCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE Sbjct 63 IDRAPQWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 122 Query 128 IIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAE 187 IIE GAIP DVTIQVLTQ RPELI+RTF+AC GA AIVHFYNSTSILQRRVVFRA++ Sbjct 123 IIEDGAIPSDVTIQVLTQSRPELIKRTFEACEGAENAIVHFYNSTSILQRRVVFRADKDT 182 Query 188 VQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPI 247 ++ IATD A + ++ KYP T WR+EYSPESYTGTELEYAK+VCDAV E + TP P+ Sbjct 183 IKKIATDAAELVLAESKKYPDTNWRWEYSPESYTGTELEYAKEVCDAVTETLGATPANPV 242 Query 248 IFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADR 307 I NLPATVEM TPNVYADSIEWM RNLA R+SVILSLHPHNDRGT VAAAELG+ AGADR Sbjct 243 ILNLPATVEMATPNVYADSIEWMHRNLARRDSVILSLHPHNDRGTGVAAAELGYQAGADR 302 Query 308 IEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 367 IEGCLFGNGERTGNVCLVTL LN+F+RGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG Sbjct 303 IEGCLFGNGERTGNVCLVTLALNMFTRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 362 Query 368 GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIR 427 GDLVYTAFSGSHQDAINKGLDAMK+DAD D DVDD+LWQVPYLPIDP+DVGR+YEAVIR Sbjct 363 GDLVYTAFSGSHQDAINKGLDAMKVDADNQDSDVDDILWQVPYLPIDPKDVGRSYEAVIR 422 Query 428 VNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEE 487 VNSQSGKGGVAYIMK DHGL LPRRLQ+EFSQ +QKI T GEGGEVSPKEMWD F EE Sbjct 423 VNSQSGKGGVAYIMKADHGLVLPRRLQVEFSQSVQKI---TDGEGGEVSPKEMWDVFHEE 479 Query 488 YLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGF 547 YLAPV PLER++Q V A+++DGGT +ITA VK+NG E EISG+GNGPLAAFV AL + F Sbjct 480 YLAPVTPLERMKQKVTASEEDGGTDAITAIVKVNGKEQEISGTGNGPLAAFVDALGSINF 539 Query 548 DVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGR 607 DV VLDY EHAMSAGDDAQAAAYVE +VT G G+ Sbjct 540 DVRVLDYSEHAMSAGDDAQAAAYVECAVT-------GPDGQ------------------- 573 Query 608 HASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAA 643 S VWGVGIA SITTASLRAVVSAVNRA+ Sbjct 574 -------STVVWGVGIATSITTASLRAVVSAVNRAS 602 >gi|229492151|ref|ZP_04385960.1| 2-isopropylmalate synthase [Rhodococcus erythropolis SK121] gi|229320939|gb|EEN86751.1| 2-isopropylmalate synthase [Rhodococcus erythropolis SK121] Length=602 Score = 974 bits (2519), Expect = 0.0, Method: Compositional matrix adjust. Identities = 477/636 (75%), Positives = 522/636 (83%), Gaps = 38/636 (5%) Query 8 DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV 67 DA+T G TI P P QP+WN Q+ SSMP RYRPFAEEVE + L +RTWPD++ Sbjct 5 DAFTT--GTRTITPPTKPAPSDQPAWNTQKNSSMPTFRYRPFAEEVETVTLPDRTWPDKI 62 Query 68 IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 127 IDRAP WCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE Sbjct 63 IDRAPQWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 122 Query 128 IIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAE 187 IIE GAIP DVTIQVLTQ RPELI+RTF+AC GA AIVHFYNSTSILQRRVVFRA++ Sbjct 123 IIEDGAIPSDVTIQVLTQSRPELIKRTFEACEGAENAIVHFYNSTSILQRRVVFRADKDT 182 Query 188 VQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPI 247 ++ IATD A + ++ KYP T WR+EYSPESYTGTELEYAK+VCDAV E + TP P+ Sbjct 183 IKKIATDAAELVLAESKKYPDTNWRWEYSPESYTGTELEYAKEVCDAVTETLGATPANPV 242 Query 248 IFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADR 307 I NLPATVEM TPNVYADSIEWM RNLA R+SVILSLHPHNDRGT VAAAELG+ AGADR Sbjct 243 ILNLPATVEMATPNVYADSIEWMHRNLARRDSVILSLHPHNDRGTGVAAAELGYQAGADR 302 Query 308 IEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 367 IEGCLFGNGERTGNVCLVTL LN+F+RGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG Sbjct 303 IEGCLFGNGERTGNVCLVTLALNMFTRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 362 Query 368 GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIR 427 GDLVYTAFSGSHQDAINKGLDAMK+DAD+ + DVDD+LWQVPYLPIDP+DVGR+YEAVIR Sbjct 363 GDLVYTAFSGSHQDAINKGLDAMKVDADSQNSDVDDILWQVPYLPIDPKDVGRSYEAVIR 422 Query 428 VNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEE 487 VNSQSGKGGVAYIMK DHGL LPRRLQ+EFSQ +QKI T GEGGEVSPKEMWD F EE Sbjct 423 VNSQSGKGGVAYIMKADHGLVLPRRLQVEFSQSVQKI---TDGEGGEVSPKEMWDVFHEE 479 Query 488 YLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGF 547 YLAP+ PLER++Q V A+++DGGT +ITA VK+NG E EISG+GNGPLAAFV AL + F Sbjct 480 YLAPITPLERMKQKVTASEEDGGTDAITAIVKVNGKEQEISGTGNGPLAAFVDALGSINF 539 Query 548 DVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGR 607 DV VLDY EHAMSAGDDAQAAAYVE +VT G G+ Sbjct 540 DVRVLDYSEHAMSAGDDAQAAAYVECAVT-------GPEGQ------------------- 573 Query 608 HASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAA 643 S VWGVGIA SITTASLRAVVSAVNRA+ Sbjct 574 -------STVVWGVGIATSITTASLRAVVSAVNRAS 602 >gi|296141655|ref|YP_003648898.1| 2-isopropylmalate synthase [Tsukamurella paurometabola DSM 20162] gi|296029789|gb|ADG80559.1| 2-isopropylmalate synthase [Tsukamurella paurometabola DSM 20162] Length=622 Score = 969 bits (2506), Expect = 0.0, Method: Compositional matrix adjust. Identities = 474/637 (75%), Positives = 521/637 (82%), Gaps = 37/637 (5%) Query 6 SPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPD 65 SP A + + G I PAGP GQP+WNPQR+S+MP +RYRPFA+EVE I L +RTWPD Sbjct 2 SPAADSYTSGVSKISTPAGPRNPGQPAWNPQRSSAMPNHRYRPFADEVEQISLPDRTWPD 61 Query 66 RVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFV 125 V D APLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFV Sbjct 62 NVADTAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFV 121 Query 126 REIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANR 185 REIIE GAIPDDVTIQVL QCR ELIERTF+AC GA IVHFYNSTS+LQRRVVFRA++ Sbjct 122 REIIEDGAIPDDVTIQVLVQCRDELIERTFEACQGAKNVIVHFYNSTSVLQRRVVFRADK 181 Query 186 AEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPER 245 A ++ IATD A K +E+ KYP T WR++YSPESYTGTEL +AK+VCDAV E+IAPTPE Sbjct 182 AAIKKIATDAAHKVLEEQKKYPDTAWRYQYSPESYTGTELSFAKEVCDAVTEIIAPTPEN 241 Query 246 PIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGA 305 P+I NLPATVEM TPNVYADSIEWMSRNL R+SVILSLHPHNDRG VAAAELG+ AGA Sbjct 242 PMILNLPATVEMATPNVYADSIEWMSRNLDRRDSVILSLHPHNDRGEGVAAAELGYLAGA 301 Query 306 DRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHP 365 DRIEGCLFGNGERTGNVCLVTLGLN+FSRG+DPQI+F++IDEIRRTVEYCNQLPV ERHP Sbjct 302 DRIEGCLFGNGERTGNVCLVTLGLNMFSRGIDPQINFADIDEIRRTVEYCNQLPVPERHP 361 Query 366 YGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAV 425 YGGDLVYTAFSGSHQDAINKGLD MK+DAD AD DVDD+LWQVPYLPIDP+DVGR+YEAV Sbjct 362 YGGDLVYTAFSGSHQDAINKGLDQMKIDADEADKDVDDILWQVPYLPIDPKDVGRSYEAV 421 Query 426 IRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFA 485 IRVNSQSGKGGVAYIMK+DHGL+LPRRLQIEFSQ +QKI T GEGGEV+PKEMWD FA Sbjct 422 IRVNSQSGKGGVAYIMKSDHGLALPRRLQIEFSQSVQKI---TDGEGGEVTPKEMWDVFA 478 Query 486 EEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADV 545 EY+ P+ PLER+RQ V A++ DG I A VK+ G E EISG GNGPLAAFV A+ V Sbjct 479 GEYIDPILPLERMRQKVTASEIDGAVDRIEAVVKVEGKEQEISGEGNGPLAAFVDAIGTV 538 Query 546 GFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEA 605 GFDV VLDY EHA+SAGDDAQAAAYVEA V + Sbjct 539 GFDVRVLDYSEHALSAGDDAQAAAYVEAIVRVGD-------------------------- 572 Query 606 GRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRA 642 +TVWGVGIAPSITTASLRAVVSAVNRA Sbjct 573 --------EDRTVWGVGIAPSITTASLRAVVSAVNRA 601 >gi|161598448|ref|YP_116514.2| 2-isopropylmalate synthase [Nocardia farcinica IFM 10152] Length=562 Score = 969 bits (2506), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/602 (79%), Positives = 511/602 (85%), Gaps = 41/602 (6%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MP RYRPFAEEVEP+ L +RTWPD+VIDRAP WCAVDLRDGNQALIDPMSPARKRRMFD Sbjct 1 MPAYRYRPFAEEVEPVTLPDRTWPDKVIDRAPGWCAVDLRDGNQALIDPMSPARKRRMFD 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTD+DFVREIIE AIPDDVTIQVLTQCRPELIERTF+AC+G Sbjct 61 LLVRMGYKEIEVGFPSASQTDYDFVREIIEDNAIPDDVTIQVLTQCRPELIERTFEACAG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 A IVHFYNSTSILQRRVVFRA+R +V+ IATD A+ C+E +YP T WR+EYSPESY Sbjct 121 AANVIVHFYNSTSILQRRVVFRADREQVKKIATDAAKLCLEVEKRYPDTNWRYEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTELEYA++VCDAV E+IAPTPE+P+I NLPATVEM TPNVYADSIEWMSRNLA RES+ Sbjct 181 TGTELEYAREVCDAVSEIIAPTPEKPLIINLPATVEMATPNVYADSIEWMSRNLARRESI 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 +LSLHPHNDRGTAVAAAELG+ AGADRIEGCLFGNGERTGNVCLVTLG+N+FSRG+DPQI Sbjct 241 VLSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGMNMFSRGIDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFS+IDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMK ADA + D Sbjct 301 DFSDIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKAAADAQNAD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 V D++W+VPYLPIDP+DVGRTYEAVIRVNSQSGKGGVAYIMKTDHGL LPRRLQIEFSQV Sbjct 361 VSDIVWEVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLVLPRRLQIEFSQV 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 +QKI T GEGGEV+PKEMWD F EEYLAP+RPLERIRQ V AA+ DGG SITA VK+ Sbjct 421 VQKI---TDGEGGEVTPKEMWDVFHEEYLAPIRPLERIRQKVTAAETDGGVDSITAVVKV 477 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 +GVE EI+G GNGPLAAFV A+A VG+DV VLDY EHAMSAGDDAQAAAYVE + Sbjct 478 DGVEQEITGQGNGPLAAFVDAIATVGYDVRVLDYSEHAMSAGDDAQAAAYVECA------ 531 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 + K VWGVGIA SITTASLRAVVSAVN Sbjct 532 --------------------------------IGDKVVWGVGIATSITTASLRAVVSAVN 559 Query 641 RA 642 RA Sbjct 560 RA 561 >gi|326383510|ref|ZP_08205197.1| 2-isopropylmalate synthase [Gordonia neofelifaecis NRRL B-59395] gi|326197916|gb|EGD55103.1| 2-isopropylmalate synthase [Gordonia neofelifaecis NRRL B-59395] Length=615 Score = 962 bits (2488), Expect = 0.0, Method: Compositional matrix adjust. Identities = 473/637 (75%), Positives = 522/637 (82%), Gaps = 43/637 (6%) Query 8 DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV 67 DA+T G IV+P GP GQP+WNPQR S+MPV+RYR FA+EVE I L +RTWPD+V Sbjct 5 DAFTS--GPSRIVEPNGPIPGGQPAWNPQRNSAMPVHRYRSFADEVEKIALPDRTWPDKV 62 Query 68 IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 127 DRAP+WCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE Sbjct 63 TDRAPMWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 122 Query 128 IIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAE 187 II+ GAIPDDVTIQVLTQ RPELI RT++AC+GA IVHFYNSTS+LQRRVVFRA++A Sbjct 123 IIDDGAIPDDVTIQVLTQARPELIARTYEACAGAQNVIVHFYNSTSVLQRRVVFRADKAA 182 Query 188 VQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPI 247 + IATD A+ C+E+ KYP T WR+EYSPESYTGTEL YAK+V DAV EVIAPTPE+P+ Sbjct 183 ITKIATDAAKLCLEEEKKYPDTNWRYEYSPESYTGTELSYAKEVVDAVSEVIAPTPEKPL 242 Query 248 IFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADR 307 I NLPATVEM TPNVYADSIEWM RNLA R+S+ILSLHPHNDRG VAAAELG+ AGADR Sbjct 243 IVNLPATVEMATPNVYADSIEWMHRNLARRDSIILSLHPHNDRGEGVAAAELGYLAGADR 302 Query 308 IEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 367 IEGCLFGNGERTGNVCLVTLG+NLFSRGVDPQI+FS+IDEIRRTVEYCNQL V ERHPYG Sbjct 303 IEGCLFGNGERTGNVCLVTLGMNLFSRGVDPQINFSDIDEIRRTVEYCNQLNVPERHPYG 362 Query 368 GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIR 427 GDLVYTAFSGSHQDAINKGLD MK+DAD AD DVDD+LWQVPYLPIDP+DVGR YEAVIR Sbjct 363 GDLVYTAFSGSHQDAINKGLDQMKIDADEADKDVDDILWQVPYLPIDPKDVGRNYEAVIR 422 Query 428 VNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEE 487 VNSQSGKGGV YIMK DHGL LPRRLQIEFS+ IQKI T GEGGEV+PK MWD FA E Sbjct 423 VNSQSGKGGVTYIMKADHGLDLPRRLQIEFSREIQKI---TDGEGGEVNPKAMWDVFARE 479 Query 488 YLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGF 547 YL PV PLER+RQHV+AA+ D G ++TA V ++GVE EISG+GNGPLAAFV AL+ +GF Sbjct 480 YLEPVTPLERMRQHVEAAETDDGEDTVTAAVLVDGVEKEISGTGNGPLAAFVDALSTIGF 539 Query 548 DVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGR 607 DV VLDY EHAM+AG DA AA+YVEA Sbjct 540 DVRVLDYSEHAMTAGGDANAASYVEAE--------------------------------- 566 Query 608 HASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 + +TVWGVGIAPSITTASLRAVVSAVNRA R Sbjct 567 -----INGETVWGVGIAPSITTASLRAVVSAVNRAFR 598 >gi|120406458|ref|YP_956287.1| 2-isopropylmalate synthase [Mycobacterium vanbaalenii PYR-1] gi|119959276|gb|ABM16281.1| 2-isopropylmalate synthase [Mycobacterium vanbaalenii PYR-1] Length=612 Score = 962 bits (2486), Expect = 0.0, Method: Compositional matrix adjust. Identities = 495/644 (77%), Positives = 532/644 (83%), Gaps = 47/644 (7%) Query 4 SESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEV---EPIRLRN 60 S S DAY+ TI PAGPP GQPSWN QR SSMPV+RYR FA EV P + Sbjct 6 SPSADAYSS---VRTITTPAGPPNPGQPSWNTQRGSSMPVSRYRNFAAEVPGGAPAAPFD 62 Query 61 RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT 120 RTWPD+VID APLWCAVDLRDGNQALIDPMSPARKRRMFDLLV+MGYKEIEVGFPSASQT Sbjct 63 RTWPDKVIDTAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVKMGYKEIEVGFPSASQT 122 Query 121 DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV 180 D+DFVREIIEQGAIPDDVTIQVLTQCR ELIERTF+AC GAP IVHFYNSTSILQRRVV Sbjct 123 DYDFVREIIEQGAIPDDVTIQVLTQCRDELIERTFEACDGAPNVIVHFYNSTSILQRRVV 182 Query 181 FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA 240 FRA+R E++ IATDGARKC+E+A K+PGT+WR+EYSPESYTGTELEYA VC+AV EVI Sbjct 183 FRADRDEIKKIATDGARKCLEEAGKHPGTRWRYEYSPESYTGTELEYALDVCNAVSEVIE 242 Query 241 PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG 300 PTP+ P+I NLPATVEM TPNVYADSIEWMSRNLA R S+ILSLHPHNDRGTAVAAAELG Sbjct 243 PTPDWPLIVNLPATVEMATPNVYADSIEWMSRNLARRGSIILSLHPHNDRGTAVAAAELG 302 Query 301 FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV 360 + AGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQL V Sbjct 303 YQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLGV 362 Query 361 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR 420 HERHPYGGDLVYTAFSGSHQDAINKGLDAMK+ AD D DVDD++WQVPYLPIDP+DVGR Sbjct 363 HERHPYGGDLVYTAFSGSHQDAINKGLDAMKISADEQDSDVDDIVWQVPYLPIDPKDVGR 422 Query 421 TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM 480 TYEAVIRVNSQSGKGGVAYIMK DHGL+LPRRLQIEFSQ IQ+I T GEGGEVSPKEM Sbjct 423 TYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQAIQQI---TDGEGGEVSPKEM 479 Query 481 WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH 540 WDAF +EYLAP+ PLERIRQ VDA++ DGGT +ITA VK+NG E EI G+GNGPLAAFV Sbjct 480 WDAFYDEYLAPITPLERIRQKVDASEVDGGTDTITAVVKVNGEEHEIVGAGNGPLAAFVD 539 Query 541 ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA 600 A+ VGF V VLDY EHAMSAG++A AAAYVEA Sbjct 540 AIGAVGFHVNVLDYSEHAMSAGEEAAAAAYVEAE-------------------------- 573 Query 601 QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 + KTVWGVGIA SITTASLRAVVSAVNRA R Sbjct 574 ------------IDGKTVWGVGIATSITTASLRAVVSAVNRAMR 605 >gi|118470831|ref|YP_890490.1| 2-isopropylmalate synthase [Mycobacterium smegmatis str. MC2 155] gi|118172118|gb|ABK73014.1| 2-isopropylmalate synthase [Mycobacterium smegmatis str. MC2 155] Length=602 Score = 961 bits (2483), Expect = 0.0, Method: Compositional matrix adjust. Identities = 481/640 (76%), Positives = 526/640 (83%), Gaps = 42/640 (6%) Query 6 SPDAYTESFG-AHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWP 64 +PD +++F TI P+G P GQP+WN QR SSMPV+RYR FA+EVE I L +RTWP Sbjct 3 TPDISSDAFSTGRTITPPSGAPHPGQPAWNTQRGSSMPVSRYRSFADEVEKISLPDRTWP 62 Query 65 DRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDF 124 D+VI+ AP+WCAVDLRDGNQALIDPMSP RKRRMFDLLVRMGYKEIEVGFPSASQTDFDF Sbjct 63 DKVIETAPMWCAVDLRDGNQALIDPMSPQRKRRMFDLLVRMGYKEIEVGFPSASQTDFDF 122 Query 125 VREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRAN 184 VREIIE AIPDDVTIQVLTQ RPELI RTF+AC GA IVHFYNSTSILQRRVVFRA+ Sbjct 123 VREIIEDNAIPDDVTIQVLTQSRPELITRTFEACRGAKNVIVHFYNSTSILQRRVVFRAD 182 Query 185 RAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPE 244 +A ++ IATD A +E+A KYP T WR+EYSPESYTGTEL YAK+VCDAV E++ TP+ Sbjct 183 KAAIKKIATDAAELVLEEAKKYPDTNWRWEYSPESYTGTELSYAKEVCDAVTEILGATPD 242 Query 245 RPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAG 304 P+I NLPATVEM TPNVYADSIEWM RNLA R+SVILSLHPHNDRGT VAAAELG+ AG Sbjct 243 NPVILNLPATVEMATPNVYADSIEWMHRNLARRDSVILSLHPHNDRGTGVAAAELGYQAG 302 Query 305 ADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERH 364 ADRIEGCLFGNGERTGNVCLVTLGLN+FSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERH Sbjct 303 ADRIEGCLFGNGERTGNVCLVTLGLNMFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERH 362 Query 365 PYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEA 424 PYGGDLVYTAFSGSHQDAINKGLD MK+DADAA D+DD+LWQVPYLPIDP+DVGRTYEA Sbjct 363 PYGGDLVYTAFSGSHQDAINKGLDQMKVDADAAGADMDDILWQVPYLPIDPKDVGRTYEA 422 Query 425 VIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAF 484 VIRVNSQSGKGGVAYIMK DHGL LPRRLQIEFSQVIQ+I T GEGGEVSPKEMWDAF Sbjct 423 VIRVNSQSGKGGVAYIMKADHGLVLPRRLQIEFSQVIQQI---TDGEGGEVSPKEMWDAF 479 Query 485 AEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALAD 544 +EEYLAP+ PLER+RQ VDAA++DGGT ITA VK+NG E EI G+GNGPLAAF AL Sbjct 480 SEEYLAPITPLERMRQKVDAAEEDGGTDKITAVVKVNGEEREIVGAGNGPLAAFCDALGA 539 Query 545 VGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGE 604 +G +V V DY EHAMSAG++AQAAAYVEA Sbjct 540 LGINVNVRDYSEHAMSAGEEAQAAAYVEAE------------------------------ 569 Query 605 AGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 + KTVWGVGIA SITTASLRAVVSAVNRAAR Sbjct 570 --------IDGKTVWGVGIATSITTASLRAVVSAVNRAAR 601 >gi|312137917|ref|YP_004005253.1| 2-isopropylmalate synthase leua [Rhodococcus equi 103S] gi|311887256|emb|CBH46565.1| 2-isopropylmalate synthase LeuA [Rhodococcus equi 103S] Length=602 Score = 957 bits (2475), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/635 (76%), Positives = 522/635 (83%), Gaps = 38/635 (5%) Query 8 DAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV 67 DA+T G+ TI P+ P QPSWN Q+ SSMP RYRPF EEVE + L +RTWPD+V Sbjct 5 DAFTS--GSRTITPPSKPAPADQPSWNTQKNSSMPTFRYRPFGEEVETVSLPDRTWPDKV 62 Query 68 IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVRE 127 IDRAP WCAVDLRDGNQALIDPMSPARKRRMF+LLVRMGYKEIEVGFPSASQTDFDFVRE Sbjct 63 IDRAPQWCAVDLRDGNQALIDPMSPARKRRMFELLVRMGYKEIEVGFPSASQTDFDFVRE 122 Query 128 IIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAE 187 IIE AIPDDVTIQVLTQ RPELI+RTF+AC GA IVHFYNSTSILQRRVVFRA++ Sbjct 123 IIEDNAIPDDVTIQVLTQSRPELIKRTFEACDGAKNVIVHFYNSTSILQRRVVFRADKDA 182 Query 188 VQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPI 247 ++ IATD A +E+A +P T WR+EYSPESYTGTEL YAK+VCDAV E + TP+ + Sbjct 183 IKKIATDAAALVLEEAKNHPDTNWRWEYSPESYTGTELSYAKEVCDAVVETLGATPDNRV 242 Query 248 IFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADR 307 I NLPATVEM TPNVYADSIEWM RNLA RES+ILSLHPHNDRGT VAAAELG+ AGADR Sbjct 243 IINLPATVEMATPNVYADSIEWMHRNLAQRESIILSLHPHNDRGTGVAAAELGYQAGADR 302 Query 308 IEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 367 IEGCLFGNGERTGNVCLVTLGLN+F+RGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG Sbjct 303 IEGCLFGNGERTGNVCLVTLGLNMFTRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG 362 Query 368 GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIR 427 GDLVYTAFSGSHQDAINKGLDAMK+ AD D DVDD++W+VPYLPIDP+DVGRTYEAVIR Sbjct 363 GDLVYTAFSGSHQDAINKGLDAMKVAADQQDADVDDIVWEVPYLPIDPKDVGRTYEAVIR 422 Query 428 VNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEE 487 VNSQSGKGGVAYIMK DHGL LPRRLQIEFSQ +QKI T GEGGEVSPKE+WD FAEE Sbjct 423 VNSQSGKGGVAYIMKADHGLVLPRRLQIEFSQAVQKI---TDGEGGEVSPKEIWDVFAEE 479 Query 488 YLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGF 547 YL+PV PLER+RQ V AA++DGGT +ITA VK+NGVE EISG+GNGPLAAFV AL VGF Sbjct 480 YLSPVSPLERMRQKVTAAEEDGGTDAITAVVKVNGVEQEISGAGNGPLAAFVDALGTVGF 539 Query 548 DVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGR 607 DV VLDY EHAMSAGDDAQAAAYVE +VT+ Sbjct 540 DVRVLDYSEHAMSAGDDAQAAAYVECAVTLPDG--------------------------- 572 Query 608 HASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRA 642 TSK VWGVGIA SITTASLRAVVSAVNRA Sbjct 573 ------TSKVVWGVGIATSITTASLRAVVSAVNRA 601 >gi|262200473|ref|YP_003271681.1| 2-isopropylmalate synthase [Gordonia bronchialis DSM 43247] gi|262083820|gb|ACY19788.1| 2-isopropylmalate synthase [Gordonia bronchialis DSM 43247] Length=617 Score = 956 bits (2472), Expect = 0.0, Method: Compositional matrix adjust. Identities = 472/638 (74%), Positives = 521/638 (82%), Gaps = 41/638 (6%) Query 7 PDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDR 66 P A T + GA IV+P+GP GQP+WN QR S+MP++RYR FA+EVE I + +RTWPD+ Sbjct 2 PAADTFTSGASRIVEPSGPIPAGQPAWNTQRGSAMPIHRYRQFADEVETISIPDRTWPDK 61 Query 67 VIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVR 126 VI +AP+W AVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTD+DFVR Sbjct 62 VITKAPMWGAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDYDFVR 121 Query 127 EIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRA 186 EIIE GAIPDDVTIQVLTQCR ELIERTF AC GA + IVHFYNSTS+LQRRVVFRA++ Sbjct 122 EIIEDGAIPDDVTIQVLTQCRDELIERTFDACRGANKVIVHFYNSTSVLQRRVVFRADKD 181 Query 187 EVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERP 246 + IATD A K + + AKYP TQWR+EYSPESYTGTEL YAK VCDAV E+IAPTP+ P Sbjct 182 AITKIATDAAHKVLVEQAKYPDTQWRYEYSPESYTGTELSYAKHVCDAVTEIIAPTPDNP 241 Query 247 IIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGAD 306 +I NLPATVEM TPNVYADSIEWM RNL R+S+ILSLHPHNDRGTAVAAAELG+ AGAD Sbjct 242 MIINLPATVEMATPNVYADSIEWMHRNLERRDSIILSLHPHNDRGTAVAAAELGYQAGAD 301 Query 307 RIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPY 366 RIEGCLFGNGERTGNVCLVTLG+NLFSRGVDPQI FS+IDEIRRTVEYCNQL V ERHPY Sbjct 302 RIEGCLFGNGERTGNVCLVTLGMNLFSRGVDPQISFSDIDEIRRTVEYCNQLNVPERHPY 361 Query 367 GGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVI 426 GGDLVYTAFSGSHQDAINKGLD MK DADA+D DVDD+LWQVPYLPIDP+DVGR YEAVI Sbjct 362 GGDLVYTAFSGSHQDAINKGLDQMKYDADASDRDVDDILWQVPYLPIDPKDVGRNYEAVI 421 Query 427 RVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAE 486 RVNSQSGKGGVAYIMK DHG++LPRRLQIEFS+ IQKI T GEGGEV+PKEMWD FAE Sbjct 422 RVNSQSGKGGVAYIMKADHGMNLPRRLQIEFSREIQKI---TDGEGGEVNPKEMWDVFAE 478 Query 487 EYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVG 546 YLAP+ PLER+RQ VDAA+ DGG ITA VK+ G E EI+GSGNGPLAAFV AL+ VG Sbjct 479 NYLAPIWPLERMRQKVDAAEVDGGEDRITAIVKVEGNEREIAGSGNGPLAAFVDALSTVG 538 Query 547 FDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAG 606 +DV VLDY EHA+++G DA AAAYVEA Sbjct 539 YDVRVLDYSEHALTSGGDASAAAYVEAE-------------------------------- 566 Query 607 RHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVG+A SITTASLRAVVSAVNRA R Sbjct 567 ------VNGETVWGVGVASSITTASLRAVVSAVNRAYR 598 >gi|325673308|ref|ZP_08153000.1| 2-isopropylmalate synthase [Rhodococcus equi ATCC 33707] gi|325555898|gb|EGD25568.1| 2-isopropylmalate synthase [Rhodococcus equi ATCC 33707] Length=567 Score = 929 bits (2400), Expect = 0.0, Method: Compositional matrix adjust. Identities = 464/602 (78%), Positives = 502/602 (84%), Gaps = 36/602 (5%) Query 41 MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD 100 MP RYRPF EEVE + L +RTWPD+VIDRAP WCAVDLRDGNQALIDPMSPARKRRMF+ Sbjct 1 MPTFRYRPFGEEVETVSLPDRTWPDKVIDRAPQWCAVDLRDGNQALIDPMSPARKRRMFE 60 Query 101 LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG 160 LLVRMGYKEIEVGFPSASQTDFDFVREIIE AIPDDVTIQVLTQ RPELI+RTF+AC G Sbjct 61 LLVRMGYKEIEVGFPSASQTDFDFVREIIEDNAIPDDVTIQVLTQSRPELIKRTFEACDG 120 Query 161 APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESY 220 A IVHFYNSTSILQRRVVFRA++ ++ IATD A +E+A +P T WR+EYSPESY Sbjct 121 AKNVIVHFYNSTSILQRRVVFRADKDAIKKIATDAAALVLEEAKNHPDTNWRWEYSPESY 180 Query 221 TGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV 280 TGTEL YAK+VCDAV E + TP+ +I NLPATVEM TPNVYADSIEWM RNLA RES+ Sbjct 181 TGTELSYAKEVCDAVVETLGATPDNRVIINLPATVEMATPNVYADSIEWMHRNLAQRESI 240 Query 281 ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI 340 ILSLHPHNDRGT VAAAELG+ AGADRIEGCLFGNGERTGNVCLVTLGLN+F+RGVDPQI Sbjct 241 ILSLHPHNDRGTGVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNMFTRGVDPQI 300 Query 341 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCD 400 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMK+ AD D D Sbjct 301 DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKVAADQQDAD 360 Query 401 VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV 460 VDD++W+VPYLPIDP+DVGRTYEAVIRVNSQSGKGGVAYIMK DHGL LPRRLQIEFSQ Sbjct 361 VDDIVWEVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLVLPRRLQIEFSQA 420 Query 461 IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI 520 +QKI T GEGGEVSPKE+WD FAEEYL+PV PLER+RQ V AA++DGGT +ITA VK+ Sbjct 421 VQKI---TDGEGGEVSPKEIWDVFAEEYLSPVSPLERMRQKVTAAEEDGGTDAITAVVKV 477 Query 521 NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASP 580 NGVE EISG+GNGPLAAFV AL VGFDV VLDY EHAMSAGDDAQAAAYVE +VT+ Sbjct 478 NGVEQEISGAGNGPLAAFVDALGTVGFDVRVLDYSEHAMSAGDDAQAAAYVECAVTLPDG 537 Query 581 AQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVN 640 TSK VWGVGIA SITTASLRAVVSAVN Sbjct 538 ---------------------------------TSKVVWGVGIATSITTASLRAVVSAVN 564 Query 641 RA 642 RA Sbjct 565 RA 566 >gi|343926431|ref|ZP_08765936.1| 2-isopropylmalate synthase [Gordonia alkanivorans NBRC 16433] gi|343763669|dbj|GAA12862.1| 2-isopropylmalate synthase [Gordonia alkanivorans NBRC 16433] Length=616 Score = 922 bits (2384), Expect = 0.0, Method: Compositional matrix adjust. Identities = 469/636 (74%), Positives = 512/636 (81%), Gaps = 41/636 (6%) Query 9 AYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVI 68 A T + GA IV+P GP QP WNPQR S+MPV+RYR FA+EVE I L +RTWPD+VI Sbjct 4 ADTFTSGASRIVEPNGPIPADQPVWNPQRNSAMPVHRYRQFADEVETISLPDRTWPDKVI 63 Query 69 DRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREI 128 +APLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTD+DFVREI Sbjct 64 TKAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDYDFVREI 123 Query 129 IEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEV 188 IE AIPDDVTIQVLTQCR ELIERTF+AC GA IVHFYNSTS+LQRRVVFRA++ + Sbjct 124 IEDNAIPDDVTIQVLTQCREELIERTFEACRGAANVIVHFYNSTSVLQRRVVFRADKPAI 183 Query 189 QAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPII 248 IATD A K +E YP T WR+EYSPESYTGTEL +AK+V DAV E+IAPTPE+P+I Sbjct 184 VKIATDAAHKVLEVEKNYPDTNWRYEYSPESYTGTELSFAKEVVDAVTEIIAPTPEKPMI 243 Query 249 FNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRI 308 NLPATVEM TPNVYADSIEWM RNLA R+S+ILSLHPHNDRGT VAAAELGF AGADRI Sbjct 244 VNLPATVEMATPNVYADSIEWMHRNLARRDSIILSLHPHNDRGTGVAAAELGFQAGADRI 303 Query 309 EGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGG 368 EGCLFGNGERTGNVCLVTLG+N+FSRGVDPQI FS+IDEIRRTVEYCNQL V ERHPYGG Sbjct 304 EGCLFGNGERTGNVCLVTLGMNMFSRGVDPQISFSDIDEIRRTVEYCNQLNVPERHPYGG 363 Query 369 DLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRV 428 DLV+TAFSGSHQDAINKGLD MK DAD AD DVDD++W VPYLPIDP+DVGR+YEAVIRV Sbjct 364 DLVFTAFSGSHQDAINKGLDQMKYDADDADSDVDDIVWAVPYLPIDPKDVGRSYEAVIRV 423 Query 429 NSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEY 488 NSQSGKGGVAYIMK DHG++LPRRLQIEFS+ IQKI T GEGGEV+PKEMWD FA+ Y Sbjct 424 NSQSGKGGVAYIMKADHGMNLPRRLQIEFSREIQKI---TDGEGGEVNPKEMWDVFAQNY 480 Query 489 LAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFD 548 L PV PLERIRQ VDAA+ DGG ITA VKI G E EI+GSGNGPLAAFV AL VG+D Sbjct 481 LHPVWPLERIRQKVDAAEVDGGEDHITAVVKIEGNEREITGSGNGPLAAFVDALGTVGYD 540 Query 549 VAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRH 608 V VLDY EHA++AG DA AAAYVE Sbjct 541 VRVLDYSEHALTAGGDASAAAYVETE---------------------------------- 566 Query 609 ASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR 644 V +TVWGVG+A SITTASLRAVVSAVNRA R Sbjct 567 ----VNGETVWGVGVASSITTASLRAVVSAVNRAYR 598 Lambda K H 0.317 0.133 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1492181782080 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40