BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3784 Length=326 Score E Sequences producing significant alignments: (Bits) Value gi|15843407|ref|NP_338444.1| hypothetical protein MT3893 [Mycoba... 672 0.0 gi|289556051|ref|ZP_06445261.1| dTDP-glucose 4,6-dehydratase [My... 672 0.0 gi|31794957|ref|NP_857450.1| dTDP-glucose 4,6-dehydratase RfbB [... 671 0.0 gi|340628754|ref|YP_004747206.1| putative dTDP-glucose 4,6-dehyd... 669 0.0 gi|289441221|ref|ZP_06430965.1| dTDP-glucose 4,6-dehydratase [My... 669 0.0 gi|289445385|ref|ZP_06435129.1| dTDP-glucose 4,6-dehydratase [My... 668 0.0 gi|289748306|ref|ZP_06507684.1| dTDP-glucose 4,6-dehydratase [My... 642 0.0 gi|183985314|ref|YP_001853605.1| dTDP-glucose-4,6-dehydratase, R... 569 2e-160 gi|254818968|ref|ZP_05223969.1| hypothetical protein MintA_03531... 460 2e-127 gi|282163443|ref|YP_003355828.1| putative nucleotide sugar epime... 232 6e-59 gi|312880523|ref|ZP_07740323.1| NAD-dependent epimerase/dehydrat... 199 3e-49 gi|336253762|ref|YP_004596869.1| dTDP-glucose 4,6-dehydratase [H... 192 8e-47 gi|146342050|ref|YP_001207098.1| putative NAD dependent epimeras... 190 2e-46 gi|281411855|ref|YP_003345934.1| NAD-dependent epimerase/dehydra... 188 1e-45 gi|332982139|ref|YP_004463580.1| NAD-dependent epimerase/dehydra... 186 6e-45 gi|148263747|ref|YP_001230453.1| NAD-dependent epimerase/dehydra... 185 7e-45 gi|332157986|ref|YP_004423265.1| UDP-glucose 4-epimerase [Pyroco... 185 9e-45 gi|261420562|ref|YP_003254244.1| NAD-dependent epimerase/dehydra... 184 2e-44 gi|339729854|emb|CCC41137.1| NAD-dependent epimerase/dehydratase... 183 3e-44 gi|311070170|ref|YP_003975093.1| NAD-dependent epimerase/dehydra... 182 5e-44 gi|89897186|ref|YP_520673.1| hypothetical protein DSY4440 [Desul... 182 9e-44 gi|315230849|ref|YP_004071285.1| UDP-glucose 4-epimerase [Thermo... 182 9e-44 gi|333911515|ref|YP_004485248.1| UDP-glucose 4-epimerase [Methan... 181 1e-43 gi|114565797|ref|YP_752951.1| nucleoside-diphosphate-sugar epime... 180 2e-43 gi|343460113|gb|AEM38549.1| dTDP-glucose 4,6-dehydratase [Pyrolo... 180 2e-43 gi|345022444|ref|ZP_08786057.1| NAD-dependent epimerase/dehydrat... 180 2e-43 gi|268680838|ref|YP_003305269.1| NAD-dependent epimerase/dehydra... 180 4e-43 gi|18978160|ref|NP_579517.1| NDP-sugar dehydratase or epimerase ... 179 4e-43 gi|322372069|ref|ZP_08046611.1| NAD-dependent epimerase/dehydrat... 179 4e-43 gi|253575887|ref|ZP_04853221.1| NAD-dependent epimerase/dehydrat... 179 5e-43 gi|153954706|ref|YP_001395471.1| nucleoside-diphosphate-sugar ep... 179 5e-43 gi|328886045|emb|CCA59284.1| dTDP-glucose 4,6-dehydratase [Strep... 179 7e-43 gi|171184952|ref|YP_001793871.1| dTDP-glucose 4,6-dehydratase [T... 178 1e-42 gi|14591500|ref|NP_143580.1| UDP-glucose 4-epimerase [Pyrococcus... 178 1e-42 gi|257052080|ref|YP_003129913.1| NAD-dependent epimerase/dehydra... 177 2e-42 gi|292670398|ref|ZP_06603824.1| NAD-dependent epimerase/dehydrat... 177 2e-42 gi|296242301|ref|YP_003649788.1| dTDP-glucose 4,6-dehydratase [T... 177 3e-42 gi|57640939|ref|YP_183417.1| UDP-glucose 4-epimerase [Thermococc... 177 3e-42 gi|302874842|ref|YP_003843475.1| NAD-dependent epimerase/dehydra... 176 4e-42 gi|83589603|ref|YP_429612.1| NAD-dependent epimerase/dehydratase... 176 4e-42 gi|340623550|ref|YP_004742003.1| dTDP-glucose 4,6-dehydratase [M... 176 5e-42 gi|255523726|ref|ZP_05390692.1| NAD-dependent epimerase/dehydrat... 176 5e-42 gi|317130294|ref|YP_004096576.1| NAD-dependent epimerase/dehydra... 176 5e-42 gi|289191516|ref|YP_003457457.1| NAD-dependent epimerase/dehydra... 176 6e-42 gi|335436900|ref|ZP_08559687.1| NAD-dependent epimerase/dehydrat... 176 7e-42 gi|41033611|emb|CAF18472.1| dTDP-D-glucose-4,6-dehydratase [Ther... 175 8e-42 gi|319789777|ref|YP_004151410.1| NAD-dependent epimerase/dehydra... 175 8e-42 gi|344338020|ref|ZP_08768953.1| dTDP-glucose 4,6-dehydratase [Th... 175 9e-42 gi|334127350|ref|ZP_08501277.1| NAD-dependent epimerase/dehydrat... 175 9e-42 gi|344330439|gb|EGW41734.1| short chain dehydrogenase family pro... 174 1e-41 >gi|15843407|ref|NP_338444.1| hypothetical protein MT3893 [Mycobacterium tuberculosis CDC1551] gi|254233278|ref|ZP_04926604.1| hypothetical protein TBCG_03711 [Mycobacterium tuberculosis C] gi|13883774|gb|AAK48258.1| NAD-dependent epimerase/dehydratase family protein [Mycobacterium tuberculosis CDC1551] gi|124603071|gb|EAY61346.1| hypothetical protein TBCG_03711 [Mycobacterium tuberculosis C] gi|323717651|gb|EGB26853.1| hypothetical protein TMMG_00278 [Mycobacterium tuberculosis CDC1551A] Length=712 Score = 672 bits (1734), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/325 (100%), Positives = 325/325 (100%), Gaps = 0/325 (0%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG Sbjct 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC Sbjct 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 Query 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV Sbjct 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 Query 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI Sbjct 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 Query 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI Sbjct 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 Query 301 DRYINWAKDQPQYPYEQDGFSGSSV 325 DRYINWAKDQPQYPYEQDGFSGSSV Sbjct 301 DRYINWAKDQPQYPYEQDGFSGSSV 325 >gi|289556051|ref|ZP_06445261.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis KZN 605] gi|289440683|gb|EFD23176.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis KZN 605] Length=351 Score = 672 bits (1733), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/326 (100%), Positives = 326/326 (100%), Gaps = 0/326 (0%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG Sbjct 26 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 85 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC Sbjct 86 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 145 Query 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV Sbjct 146 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 205 Query 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI Sbjct 206 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 265 Query 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI Sbjct 266 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 325 Query 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 DRYINWAKDQPQYPYEQDGFSGSSVL Sbjct 326 DRYINWAKDQPQYPYEQDGFSGSSVL 351 >gi|31794957|ref|NP_857450.1| dTDP-glucose 4,6-dehydratase RfbB [Mycobacterium bovis AF2122/97] gi|57117156|ref|YP_178015.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis H37Rv] gi|121639701|ref|YP_979925.1| putative dTDP-glucose 4,6-dehydratase rfbB [Mycobacterium bovis BCG str. Pasteur 1173P2] 63 more sequence titles Length=326 Score = 671 bits (1731), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/326 (100%), Positives = 326/326 (100%), Gaps = 0/326 (0%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG Sbjct 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC Sbjct 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 Query 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV Sbjct 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 Query 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI Sbjct 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 Query 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI Sbjct 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 Query 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 DRYINWAKDQPQYPYEQDGFSGSSVL Sbjct 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 >gi|340628754|ref|YP_004747206.1| putative dTDP-glucose 4,6-dehydratase [Mycobacterium canettii CIPT 140010059] gi|340006944|emb|CCC46135.1| putative dTDP-glucose 4,6-dehydratase [Mycobacterium canettii CIPT 140010059] Length=326 Score = 669 bits (1726), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/326 (99%), Positives = 325/326 (99%), Gaps = 0/326 (0%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG Sbjct 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC Sbjct 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 Query 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 EVYGDGHNLKEGERLDEH ELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV Sbjct 121 EVYGDGHNLKEGERLDEHTELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 Query 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI Sbjct 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 Query 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI Sbjct 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 Query 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 DRYINWAKDQPQYPYEQDGFSGSSVL Sbjct 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 >gi|289441221|ref|ZP_06430965.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis T46] gi|289572033|ref|ZP_06452260.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis T17] gi|289414140|gb|EFD11380.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis T46] gi|289545787|gb|EFD49435.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis T17] Length=326 Score = 669 bits (1726), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/326 (99%), Positives = 325/326 (99%), Gaps = 0/326 (0%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG Sbjct 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC Sbjct 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 Query 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV Sbjct 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 Query 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI Sbjct 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 Query 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWD I Sbjct 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDSI 300 Query 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 DRYINWAKDQPQYPYEQDGFSGSSVL Sbjct 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 >gi|289445385|ref|ZP_06435129.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis CPHL_A] gi|289418343|gb|EFD15544.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis CPHL_A] Length=326 Score = 668 bits (1724), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/326 (99%), Positives = 325/326 (99%), Gaps = 0/326 (0%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG Sbjct 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC Sbjct 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 Query 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV Sbjct 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 Query 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLR QAI Sbjct 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRVQAI 240 Query 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI Sbjct 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 Query 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 DRYINWAKDQPQYPYEQDGFSGSSVL Sbjct 301 DRYINWAKDQPQYPYEQDGFSGSSVL 326 >gi|289748306|ref|ZP_06507684.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis T92] gi|289688893|gb|EFD56322.1| dTDP-glucose 4,6-dehydratase [Mycobacterium tuberculosis T92] Length=328 Score = 642 bits (1655), Expect = 0.0, Method: Compositional matrix adjust. Identities = 313/321 (98%), Positives = 315/321 (99%), Gaps = 0/321 (0%) Query 6 TGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQTIDR 65 TG +G G+ TESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQTIDR Sbjct 8 TGVSGHAGAVQTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQTIDR 67 Query 66 AVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEVYGD 125 AVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEVYGD Sbjct 68 AVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEVYGD 127 Query 126 GHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQKAG 185 GHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQKAG Sbjct 128 GHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQKAG 187 Query 186 RFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINFASG 245 RFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINFASG Sbjct 188 RFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINFASG 247 Query 246 KDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGIDRYIN 305 KDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWD IDRYIN Sbjct 248 KDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDSIDRYIN 307 Query 306 WAKDQPQYPYEQDGFSGSSVL 326 WAKDQPQYPYEQDGFSGSSVL Sbjct 308 WAKDQPQYPYEQDGFSGSSVL 328 >gi|183985314|ref|YP_001853605.1| dTDP-glucose-4,6-dehydratase, RmlB_1 [Mycobacterium marinum M] gi|183178640|gb|ACC43750.1| dTDP-glucose-4,6-dehydratase, RmlB_1 [Mycobacterium marinum M] Length=328 Score = 569 bits (1467), Expect = 2e-160, Method: Compositional matrix adjust. Identities = 267/325 (83%), Positives = 296/325 (92%), Gaps = 0/325 (0%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 MEILV GGAGFQGSHLTESLLA+GHWVTVL+ S+N RNMQGF+SH+R +FISGSVTDG Sbjct 1 MEILVIGGAGFQGSHLTESLLADGHWVTVLNTPSKNTTRNMQGFQSHERVSFISGSVTDG 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 +T+ RAVRDHHVVFHLAA NVD+SL DP+SFLETNVMGTYR LEAVRRYRNRLIYVSTC Sbjct 61 ETVYRAVRDHHVVFHLAARTNVDESLSDPKSFLETNVMGTYRALEAVRRYRNRLIYVSTC 120 Query 121 EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 EVYGDGHNL+EG+RLDEHAELKPNSPY ASKAAADRLCYSYFRS+G+DVTIVRPFNIFG+ Sbjct 121 EVYGDGHNLEEGQRLDEHAELKPNSPYAASKAAADRLCYSYFRSFGIDVTIVRPFNIFGI 180 Query 181 RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 RQK GRFGALIPRLVRQ ING+ LTIFGAG+++RDYLY+SDIV AYNL+L+TP+LRGQ I Sbjct 181 RQKTGRFGALIPRLVRQAINGKNLTIFGAGTSSRDYLYISDIVNAYNLILQTPSLRGQTI 240 Query 241 NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 NFASGKDT V+DIVEYVA KF A IEHRDARPGEVQRFPADISLA+SIGF+PQV+IW+GI Sbjct 241 NFASGKDTCVKDIVEYVAGKFDATIEHRDARPGEVQRFPADISLARSIGFEPQVDIWEGI 300 Query 301 DRYINWAKDQPQYPYEQDGFSGSSV 325 DRYI WAKDQPQ+ YE DG S Sbjct 301 DRYIAWAKDQPQHAYELDGLGDRST 325 >gi|254818968|ref|ZP_05223969.1| hypothetical protein MintA_03531 [Mycobacterium intracellulare ATCC 13950] Length=271 Score = 460 bits (1183), Expect = 2e-127, Method: Compositional matrix adjust. Identities = 219/266 (83%), Positives = 241/266 (91%), Gaps = 0/266 (0%) Query 57 VTDGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIY 116 +TDG+T+ RAVR+HHVVFHLAA++NVDQSLGDPESFLETNVMGTYRVLEAVRRY+NRLIY Sbjct 1 MTDGETVHRAVREHHVVFHLAANINVDQSLGDPESFLETNVMGTYRVLEAVRRYKNRLIY 60 Query 117 VSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFN 176 VSTCEVYGDGHNL++GE LDE AELKPNSPYGASKAAADRLCYSY+RSYGLDVTIVRPFN Sbjct 61 VSTCEVYGDGHNLRDGELLDETAELKPNSPYGASKAAADRLCYSYYRSYGLDVTIVRPFN 120 Query 177 IFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLR 236 IFGVRQK GRFGALIPRLVRQ INGE LTIFG GSA+RDYLYVSDIV AY LVL LR Sbjct 121 IFGVRQKTGRFGALIPRLVRQAINGENLTIFGDGSASRDYLYVSDIVRAYTLVLENSALR 180 Query 237 GQAINFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEI 296 G+AINFASG +TRV+DIVEYVA KF A+IE R+AR GEV RFPA+I AKS+GF+P+V I Sbjct 181 GRAINFASGINTRVKDIVEYVAGKFDAKIERREARAGEVARFPANIDFAKSLGFKPEVGI 240 Query 297 WDGIDRYINWAKDQPQYPYEQDGFSG 322 W+GIDRYI WAKDQPQY Y+QDG SG Sbjct 241 WEGIDRYIQWAKDQPQYSYQQDGVSG 266 >gi|282163443|ref|YP_003355828.1| putative nucleotide sugar epimerase/dehydratase [Methanocella paludicola SANAE] gi|282155757|dbj|BAI60845.1| putative nucleotide sugar epimerase/dehydratase [Methanocella paludicola SANAE] Length=321 Score = 232 bits (591), Expect = 6e-59, Method: Compositional matrix adjust. Identities = 126/312 (41%), Positives = 183/312 (59%), Gaps = 10/312 (3%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 M IL+TGGAGF GSHL + NG V LD ++ N++ H I+G + + Sbjct 1 MNILITGGAGFVGSHLCDKYTLNGDKVICLDNFMNGSLTNIRHLIGHRNFKLINGDIRNF 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYR-NRLIYVST 119 +++ +RD VVFHLAA ++VD+S+ +P+ + NV+GT VLEA R Y ++I+ ST Sbjct 61 DLLEKIMRDVDVVFHLAAQIHVDRSVVEPKLTYDINVIGTQNVLEAARMYDVQKVIHAST 120 Query 120 CEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG 179 EVYG + +DE L PYGASK AADRLC+SY +YG+++ I+RPFN++G Sbjct 121 SEVYGS----TQYAPMDEDHPLNAPHPYGASKIAADRLCFSYINTYGMNICIMRPFNLYG 176 Query 180 VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQA 239 RQK +G I ++ +N IFG G TRDY YV DIV AY+L+L GQ Sbjct 177 PRQKDTGYGGAISIFTKRVLNNMPPIIFGDGEQTRDYTYVEDIVEAYDLILHHEGRMGQP 236 Query 240 INFASGKDTRVRDIVEYVADKFGARIEHR----DARPGEVQRFPADISLAKSI-GFQPQV 294 +NF +G + ++ D+ + G + + + RPGEV R ADIS AKS+ G++P Sbjct 237 MNFGTGNEIKILDLARLIIKMCGKEGQIKPVCVEPRPGEVVRLIADISRAKSVLGWKPHY 296 Query 295 EIWDGIDRYINW 306 I G+ +Y++W Sbjct 297 SIEMGLGKYLDW 308 >gi|312880523|ref|ZP_07740323.1| NAD-dependent epimerase/dehydratase [Aminomonas paucivorans DSM 12260] gi|310783814|gb|EFQ24212.1| NAD-dependent epimerase/dehydratase [Aminomonas paucivorans DSM 12260] Length=311 Score = 199 bits (507), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 113/313 (37%), Positives = 184/313 (59%), Gaps = 8/313 (2%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 M LVTGGAGF GS+L ++LLA+GH VTVLD S N+ R + F+ G V D Sbjct 1 MNCLVTGGAGFIGSNLVDALLADGHGVTVLDDLSSGYGENLAHLRGREGFRFLEGDVRDE 60 Query 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNR-LIYVST 119 + +A R VFHLAA V +S+ +P + + NV+GT +VLEA R R +++ S+ Sbjct 61 ALLAQAARGQEAVFHLAASVGNKRSIDNPLTDADINVLGTLKVLEAARSAGCRKVVFSSS 120 Query 120 CEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG 179 ++G+ L + E ++P+SPYG +K A++LC +Y + Y L+ +R FN++G Sbjct 121 AGIFGELKTLP----IAEDHPVEPDSPYGCTKLCAEKLCLAYAKLYDLEAVALRYFNVYG 176 Query 180 VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQA 239 RQ+ +G +IP V Q + GE +T+FG G TRD+++V D+V A + + G A Sbjct 177 PRQRFDAYGNVIPIFVFQILRGEPITVFGDGEQTRDFVHVRDVVQANVKAALSREVSG-A 235 Query 240 INFASGKDTRVRDIVEYVADK-FGARIEHRDARPGEVQRFPADISLAKS-IGFQPQVEIW 297 N ASG + D+V+ + + ++ RPG+V+ AD+ A++ +GF+P+V++ Sbjct 236 FNIASGTRITLNDLVDLLRETGLSPKVLSGPPRPGDVRHSLADLRQARTLLGFEPRVDLR 295 Query 298 DGIDRYINWAKDQ 310 +G+ Y+ WA+++ Sbjct 296 EGLKEYVAWAREE 308 >gi|336253762|ref|YP_004596869.1| dTDP-glucose 4,6-dehydratase [Halopiger xanaduensis SH-6] gi|335337751|gb|AEH36990.1| dTDP-glucose 4,6-dehydratase [Halopiger xanaduensis SH-6] Length=315 Score = 192 bits (487), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 117/312 (38%), Positives = 165/312 (53%), Gaps = 8/312 (2%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 ++VTG AGF G + LL G+ V LD S + RN+Q F D I G V D T Sbjct 5 VIVTGAAGFIGRWVVRELLERGYSVRGLDDFSNGSRRNIQAFGDRDDFELIEGDVCDDAT 64 Query 63 IDRAVR-DHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCE 121 + + HLAA ++V +SL DP+S E+NV+GT VLEA RR RL V TC Sbjct 65 VSELFDVNPAACIHLAAEIDVQESLEDPQSHFESNVVGTQTVLEACRRTETRLGLVGTCM 124 Query 122 VYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVR 181 VY D + +EG +DE +KP SPY SK AA+ L SY+ Y L V ++RPFN +G Sbjct 125 VY-DMADSEEG--IDEEHPVKPASPYAGSKLAAENLAESYYHGYDLPVVVLRPFNTYGPY 181 Query 182 QKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAIN 241 QK G G ++ + + GE L IFG G+ +RD LY +D G+ +N Sbjct 182 QKTGMAGGVVSIFTDRDLQGEPLKIFGDGTQSRDLLYATDCARFIVEGTFCDDAIGEILN 241 Query 242 FASGKDTRVRDIVEYVADKFG--ARIEHRDARPGEVQRFPADISLAKS-IGFQPQVEIWD 298 +G D V D+ E +A + +EH + EVQ D S A++ + ++P+V + + Sbjct 242 AGTGSDISVNDLAELIASEETEITHVEHHHPQ-SEVQTLRCDPSKAQAMLDWEPEVSLEE 300 Query 299 GIDRYINWAKDQ 310 G+DR W +DQ Sbjct 301 GVDRLRTWLRDQ 312 >gi|146342050|ref|YP_001207098.1| putative NAD dependent epimerase/dehydratase family protein [Bradyrhizobium sp. ORS 278] gi|146194856|emb|CAL78881.1| putative NAD dependent epimerase/dehydratase family protein [Bradyrhizobium sp. ORS 278] Length=339 Score = 190 bits (483), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 119/320 (38%), Positives = 173/320 (55%), Gaps = 11/320 (3%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 ILVTGGAGF GSHL E LL++G+ VTVLD S ++ N+ R I GSV D Q Sbjct 5 ILVTGGAGFIGSHLVEHLLSSGYVVTVLDDLSTGSIDNLAEANETGRLRLIEGSVLDAQA 64 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYR-NRLIYVSTCE 121 ++ A+ VFHLA V +SLG P E N GT R+LEA R++ R +Y S+ E Sbjct 65 VETAMHQCDYVFHLAVQC-VRKSLGKPIENHEINATGTLRMLEAARKHNIKRFVYCSSSE 123 Query 122 VYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVR 181 VYG ++ G LDE +P + YGA+K A + +Y ++YGL +VRPFN +G R Sbjct 124 VYG---SVSTG-LLDEDTLCRPVTVYGAAKLAGELYTDAYHQTYGLPTVVVRPFNAYGPR 179 Query 182 -QKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI 240 + G +IPR + +NG IFG GS RD+ YV+++ L L G + Sbjct 180 AHERGDLAEVIPRFFIRCLNGLPPVIFGDGSNGRDFTYVTEVARGLALACDADGLVGSKV 239 Query 241 NFASGKDTRVRDIVEYVADKFGAR---IEHRDARPGEVQRFPADISLAKS-IGFQPQVEI 296 N A G+ + + V G IEH RPG+V+ AD+S A+ +G++ +++ Sbjct 240 NIAYGQMISIGQVAAEVIKATGRNDLGIEHISGRPGDVRVLSADVSRARRLLGYRAEIDF 299 Query 297 WDGIDRYINWAKDQPQYPYE 316 G+ RY++W + + P + Sbjct 300 AHGLRRYLDWFRLKHSDPSQ 319 >gi|281411855|ref|YP_003345934.1| NAD-dependent epimerase/dehydratase [Thermotoga naphthophila RKU-10] gi|281372958|gb|ADA66520.1| NAD-dependent epimerase/dehydratase [Thermotoga naphthophila RKU-10] Length=323 Score = 188 bits (478), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 117/319 (37%), Positives = 179/319 (57%), Gaps = 16/319 (5%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDK-SSRNAVRNMQGFRSHDRAAFISGSVTD 59 M+ILVTG GF GSHLTE L+ GH V + +SRN ++ + D+ +G V D Sbjct 1 MKILVTGAGGFIGSHLTEFLIEKGHDVRAFVRYNSRNFWGWLEKSKVIDKIEVYTGDVRD 60 Query 60 GQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVR-RYRNRLIYVS 118 ++ A++ VVFHLAA + + S P ++++TNV GTY +L+A R R +R+++ S Sbjct 61 YDSVYNAMKGVDVVFHLAALIGIPYSYISPLAYIKTNVEGTYNILQAARERKVSRVVHTS 120 Query 119 TCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIF 178 T E+YG + +DE P SPY ASKAAAD L S++RS+GL VTI+RPFN + Sbjct 121 TSEIYGTAQYVP----IDEKHPYNPQSPYAASKAAADHLALSFYRSFGLPVTIIRPFNTY 176 Query 179 GVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQ 238 G RQ A A+IP ++ Q ++G+ G TRD+ +V DIV + V P G+ Sbjct 177 GPRQSA---RAVIPTIIIQILSGKERIKLGNLRPTRDFNFVIDIVRGFYEVGLHPDSVGE 233 Query 239 AINFASGKDTRVRDIVEYVADKFGARIE----HRDARP--GEVQRFPADISLAKSI-GFQ 291 N +G++ + D+ + +A G ++E RP EV+R AD + A + G++ Sbjct 234 VFNLGTGREVSIGDLPKIIAKLIGKKVEVEMDKNRFRPEKSEVERLCADATKAAELSGWK 293 Query 292 PQVEIWDGIDRYINWAKDQ 310 P+ +G+ I W +D+ Sbjct 294 PKYSFEEGLKITIEWFRDR 312 >gi|332982139|ref|YP_004463580.1| NAD-dependent epimerase/dehydratase [Mahella australiensis 50-1 BON] gi|332699817|gb|AEE96758.1| NAD-dependent epimerase/dehydratase [Mahella australiensis 50-1 BON] Length=314 Score = 186 bits (471), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 105/316 (34%), Positives = 170/316 (54%), Gaps = 9/316 (2%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDR-AAFISGSVTD 59 M +L+TGGAGF G + + LL +GH V +LD S + N+ F + AF G + D Sbjct 1 MNVLLTGGAGFIGRWVAKRLLEDGHDVWILDNLSNGSRNNIAEFAGDNHLKAFAEGDIKD 60 Query 60 GQTIDRAVRD-HHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVS 118 + ++ + + +HLAA +NV S+ DP + + +GT+ +LE R++ +++++S Sbjct 61 TKLLEDIFQQPFDICYHLAASINVQDSIDDPAATFHNDAVGTFNILEQCRKHHTKMVFMS 120 Query 119 TCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIF 178 TC VY D N G+ +DEH KP SPY +K A + + SY+ +Y L T++RPFN + Sbjct 121 TCMVY-DKANASSGKAIDEHHPTKPASPYAGAKIAGENMVLSYWYAYNLPTTVIRPFNTY 179 Query 179 GVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQ 238 G QK+ G ++ +++ + + L I+G G+ TRD LYV D + G Sbjct 180 GPFQKSSGEGGVVAIFIKRDLENQTLNIYGDGTQTRDLLYVEDCARFVVQTGYSDKANGH 239 Query 239 AINFASGKDTRVRDIVEYVA-DKFGARIEH-RDARP-GEVQRFPADISLAKS-IGFQPQV 294 IN +G+D V D+ + DK RI+H P E+Q+ D + AK + +QP++ Sbjct 240 IINAGTGRDISVNDLAAIICPDK--KRIKHVPHIHPQSEIQKLLCDYTKAKKLLDWQPEI 297 Query 295 EIWDGIDRYINWAKDQ 310 + GI+R W K Q Sbjct 298 TLEKGIERTRQWIKKQ 313 >gi|148263747|ref|YP_001230453.1| NAD-dependent epimerase/dehydratase [Geobacter uraniireducens Rf4] gi|146397247|gb|ABQ25880.1| NAD-dependent epimerase/dehydratase [Geobacter uraniireducens Rf4] Length=309 Score = 185 bits (470), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 114/320 (36%), Positives = 173/320 (55%), Gaps = 20/320 (6%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSH----DRAAFISGS 56 M LVTGGAGF GS+L + LL +GH VTVLD + G+RS+ I G Sbjct 1 MRTLVTGGAGFIGSNLVKQLLKDGHEVTVLDNL-------LSGYRSNIATFPEVCLIEGD 53 Query 57 VTDGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIY 116 + D + A++ VVFHLAA V +S+ P E NV+GT ++LEA R++ R I Sbjct 54 IRDDVVVAEAMKGVEVVFHLAASVGNKRSIDHPILDAEINVIGTLKILEAARKFGIRKIV 113 Query 117 VSTCE-VYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPF 175 S+ ++G+ L + E ++P+SPYG++K ++ C SY + Y L+ +R F Sbjct 114 ASSSAGIFGELKTLP----IKEDHPVEPDSPYGSTKLCMEKECLSYAKLYDLEAVCLRYF 169 Query 176 NIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTL 235 N++G+ Q+ +G +IP + + GE LTIFG G TRD+L V D+V A T + Sbjct 170 NVYGLNQRFDAYGNVIPIFAYKMLRGEPLTIFGDGEQTRDFLDVRDVVQANIKAAMTLGV 229 Query 236 RGQAINFASGKDTRVRDIVEYV--ADKFGARIEHRDARPGEVQRFPADISLA-KSIGFQP 292 G A N ASG + +VE + A ++H RPG+V ADI A ++ F P Sbjct 230 SG-AFNIASGSRITINRLVELLSAASAINPLVQHGPPRPGDVMHSLADIRAAHEAFDFTP 288 Query 293 QVEIWDGIDRYINWAKDQPQ 312 ++ + DG+ Y+ W K++ + Sbjct 289 EINLEDGLREYMVWVKEEAE 308 >gi|332157986|ref|YP_004423265.1| UDP-glucose 4-epimerase [Pyrococcus sp. NA2] gi|331033449|gb|AEC51261.1| UDP-glucose 4-epimerase [Pyrococcus sp. NA2] Length=306 Score = 185 bits (470), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 104/310 (34%), Positives = 171/310 (56%), Gaps = 13/310 (4%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 +++TGGAGF GSHL E+L A + V V+D + N+ + F+ V D + Sbjct 6 VVITGGAGFIGSHLAEAL-AEDNDVVVIDNLYSGKLENIP-----ENVKFVEADVRDYEK 59 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEV 122 I +R+ VFH AA ++V++S+ DP E NV+GT VL A+ +LI+ S+ V Sbjct 60 IADIIREADYVFHEAAQISVEESIRDPVFTEEVNVIGTINVLRALAEGEGKLIFASSAAV 119 Query 123 YGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQ 182 YGD L + E +EL+P SPYG +K + C Y+ YG+ + ++R FN++G RQ Sbjct 120 YGDPIELP----IKEDSELRPISPYGITKLTGEHYCRVYYELYGVPIVVLRYFNVYGPRQ 175 Query 183 KAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINF 242 + + +I + + I GE L I+G G TRD+++V D+V A LV + G+ N Sbjct 176 SSA-YAGVISIFMERAIRGEPLIIYGDGKQTRDFIFVKDVVDANLLVAKKERANGEVFNV 234 Query 243 ASGKDTRVRDIVEYVAD--KFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 A+G++T + D+ V + ++I RPG+++R ADI + +GF+P+ + +G+ Sbjct 235 ATGRETMIIDLALKVIELSSSPSQIIFYPPRPGDIKRSVADIGKIRKLGFKPKYSLEEGL 294 Query 301 DRYINWAKDQ 310 +W K + Sbjct 295 KETFSWFKSR 304 >gi|261420562|ref|YP_003254244.1| NAD-dependent epimerase/dehydratase [Geobacillus sp. Y412MC61] gi|319768231|ref|YP_004133732.1| NAD-dependent epimerase/dehydratase [Geobacillus sp. Y412MC52] gi|261377019|gb|ACX79762.1| NAD-dependent epimerase/dehydratase [Geobacillus sp. Y412MC61] gi|317113097|gb|ADU95589.1| NAD-dependent epimerase/dehydratase [Geobacillus sp. Y412MC52] Length=315 Score = 184 bits (466), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 109/314 (35%), Positives = 171/314 (55%), Gaps = 10/314 (3%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSH-DRAAFISGSVTD 59 M IL+TGGAGF G + + LL +GH V +LD S N+ FR H + FI G + D Sbjct 1 MRILLTGGAGFIGRAVAKRLLDDGHDVWILDDLSNGREENISEFRHHPNLKQFIVGDIKD 60 Query 60 GQTIDRAVRDHH--VVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYV 117 + + + +H + +HLAA +NV S+ DP + + +GT+ +LE R++R +L+++ Sbjct 61 ERLLAQLFHEHEYDLCYHLAASINVQDSIDDPRTTFYNDTIGTFYLLEQCRKHRTKLVFM 120 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 STC VY ++ + G + E KP SPY +K AA+ + SYF +Y L V +VRPFN Sbjct 121 STCMVYDRCYH-ETG--IAETHPTKPASPYAGAKIAAENMVLSYFYAYHLPVVVVRPFNT 177 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRG 237 +G QK G ++ +R+ + GE L I+G G+ TRD LYV D + + G Sbjct 178 YGPYQKTSGEGGVVAIFIRKKLMGETLQIYGDGTQTRDLLYVDDCARFVVQAGYSDKVNG 237 Query 238 QAINFASGKDTRVRDIVEYVADKFGARIEH-RDARP-GEVQRFPADISLAKS-IGFQPQV 294 + +N G+D + D+ + + RIEH P E+Q+ + AK +G++PQV Sbjct 238 EIVNAGLGRDISINDLAKLIVGD-EKRIEHVPHIHPQSEIQKLLCNYEKAKRLLGWEPQV 296 Query 295 EIWDGIDRYINWAK 308 + +GI + W K Sbjct 297 SLEEGIQKTEEWIK 310 >gi|339729854|emb|CCC41137.1| NAD-dependent epimerase/dehydratase family protein [Haloquadratum walsbyi C23] Length=318 Score = 183 bits (464), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 115/316 (37%), Positives = 166/316 (53%), Gaps = 12/316 (3%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 ++VTG AGF G + LL G V +D + RN+ F + D F +GSVT Sbjct 6 VVVTGAAGFIGRWVVHELLERGFTVHGIDDLRNGSQRNIAAFDTEDAFEFTTGSVTTRDD 65 Query 63 IDRAVRDHHVVF--HLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC 120 ++ AV V F HLAA ++V +SL DP+S E N++GT VLE R L V TC Sbjct 66 VE-AVLTEEVDFCIHLAAEIDVQESLDDPDSHFEANIVGTKHVLEFCRENEIALGLVGTC 124 Query 121 EVYGDGHNLKEGER-LDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG 179 VY ++ E E +DE +KP SPY SK AA+ L SY+ YGL VTI+RPFN +G Sbjct 125 MVY----DMVESEAGIDESHPVKPASPYAGSKLAAENLAESYYHGYGLPVTIMRPFNTYG 180 Query 180 VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQA 239 QK G G ++ + I G+ LTI+G G+ TRD LYV+D + G+ Sbjct 181 PFQKTGMAGGVVSIFTNRDIAGKSLTIYGDGTQTRDLLYVTDCAEFIIEATLSDETTGEI 240 Query 240 INFASGKDTRVRDIVEYVADKFGARIEHRDAR--PGEVQRFPADISLAKS-IGFQPQVEI 296 +N +G D + ++ E +A + IEH + EV++ D + A+S I ++P V + Sbjct 241 LNAGTGTDISINELAELIASE-DTEIEHVEHHHPQSEVEKLLCDPAKARSMIDWEPTVSL 299 Query 297 WDGIDRYINWAKDQPQ 312 +G+ R W K + Sbjct 300 AEGVSRLREWLKSHEE 315 >gi|311070170|ref|YP_003975093.1| NAD-dependent epimerase/dehydratase [Bacillus atrophaeus 1942] gi|310870687|gb|ADP34162.1| NAD-dependent epimerase/dehydratase [Bacillus atrophaeus 1942] Length=314 Score = 182 bits (463), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 107/314 (35%), Positives = 172/314 (55%), Gaps = 11/314 (3%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDR-AAFISGSVTD 59 M +LVTGGAGF G + + LL + H V VLD S + N++ ++ FI+G + D Sbjct 1 MNVLVTGGAGFIGRWVVKKLLEDRHQVWVLDDLSNGRLENIEELKNDPGFIEFINGDIKD 60 Query 60 GQTI-DRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVS 118 +T+ D ++ + +HL A +NV S+ DP++ E + +GT+ +LE +++ +++++S Sbjct 61 AKTLEDLFLKKFDICYHLGASINVQDSIDDPKTTFENDTIGTFNILELCKKHNVKVVFMS 120 Query 119 TCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIF 178 TC VY D EG + E +KP SPY SK AA+ + SY+ +YGL ++RPFN + Sbjct 121 TCMVY-DRAAFAEG--IKETDPIKPASPYAGSKIAAENMVLSYYHAYGLPAVVIRPFNTY 177 Query 179 GVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQ 238 G QK G G +I ++ ++G+ L I+G G+ TRD LYV D + G+ Sbjct 178 GPYQKTGGEGGVIAIFIKNKLDGKKLHIYGDGTQTRDLLYVEDCAHFVVQAGYSQKANGE 237 Query 239 AINFASGKDTRVRDIVEYVA-DKFGARIEHRD-ARP-GEVQRFPADISLAKSI-GFQPQV 294 IN G+D + D+ E +A DK +I H + P E+ + + AK I + PQV Sbjct 238 IINAGLGRDISINDLAELIAGDK--QKIHHVEHIHPQSEIPKLLCNYEKAKKILNWSPQV 295 Query 295 EIWDGIDRYINWAK 308 + +GI + W K Sbjct 296 SLEEGIRKTEEWIK 309 >gi|89897186|ref|YP_520673.1| hypothetical protein DSY4440 [Desulfitobacterium hafniense Y51] gi|219666948|ref|YP_002457383.1| NAD-dependent epimerase/dehydratase [Desulfitobacterium hafniense DCB-2] gi|89336634|dbj|BAE86229.1| hypothetical protein [Desulfitobacterium hafniense Y51] gi|219537208|gb|ACL18947.1| NAD-dependent epimerase/dehydratase [Desulfitobacterium hafniense DCB-2] Length=328 Score = 182 bits (461), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 114/316 (37%), Positives = 174/316 (56%), Gaps = 19/316 (6%) Query 2 EILVTGGAGFQGSHLTESLLANGHWVTVLDK-SSRNAVRNMQGFRSH--DRAAFISGSVT 58 ++LVTG GF GSHLTE+L+ G V V + +SR+ N++ ++ I+G + Sbjct 6 KVLVTGAGGFIGSHLTEALVKAGADVRVFIRYNSRDGRGNLEDLEPSLLNQIEIIAGDLR 65 Query 59 DGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYR-NRLIYV 117 D IDRAV+ + VVFHLAA V + S +P +ETN+ GT+ +L A R + +R++ Sbjct 66 DADVIDRAVKGNDVVFHLAALVGIPYSYKNPREVVETNIFGTFNILIAGRDHEVSRVVST 125 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 ST EVYG + +DE+ L+ SPY ASK AD+L S++ SY L V +RPFN Sbjct 126 STSEVYGSAQYVP----IDENHPLQGQSPYSASKIGADKLAESFYASYNLPVATIRPFNC 181 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRG 237 +G RQ A A+IP L+ Q + + + G A RD+ +VSD V + +P G Sbjct 182 YGPRQSA---RAIIPTLITQALASSEIKL-GNLEAKRDFTFVSDTVAGFMAAALSPKTVG 237 Query 238 QAINFASGKDTRVRDIVEYVADKFGAR----IEHRDARP--GEVQRFPADISLAKSI-GF 290 + IN SG++ + ++ + + + + I+ RP EV R AD LAK I + Sbjct 238 KVINVGSGQEISIGELAQIILETTQSSAKLVIDQERVRPSKSEVNRLLADSRLAKEIMDW 297 Query 291 QPQVEIWDGIDRYINW 306 +PQV + +GI + + W Sbjct 298 EPQVSLTEGILKTMAW 313 >gi|315230849|ref|YP_004071285.1| UDP-glucose 4-epimerase [Thermococcus barophilus MP] gi|315183877|gb|ADT84062.1| UDP-glucose 4-epimerase [Thermococcus barophilus MP] Length=308 Score = 182 bits (461), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 106/310 (35%), Positives = 161/310 (52%), Gaps = 12/310 (3%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 I+VTGGAGF GSH+ E L + + V V+D V N+ + FI + D ++ Sbjct 7 IVVTGGAGFIGSHIAEEL-SEDNEVVVIDNLYSGKVENVP-----ENVKFIQADIRDYES 60 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEV 122 I + VFH AA V+V +S+ P E NV+GT +L+A+ +LI+ S+ V Sbjct 61 IAEIISQADYVFHEAALVSVVESVEKPILTEEINVLGTLNILKALSEGHGKLIFASSAAV 120 Query 123 YGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQ 182 YGD NL L E + KP SPYG +K + + C ++ YG+ +R FN+FG RQ Sbjct 121 YGDNQNLP----LKEDEKPKPLSPYGVTKVSGEYYCRVFYELYGVPTVTLRYFNVFGERQ 176 Query 183 KAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINF 242 ++ +I + + + E L IFG G TRD++YV D+V A LV G+ N Sbjct 177 GYNQYAGVISIFINRALKNEPLIIFGDGKQTRDFIYVKDVVKANILVAEKEKANGEVFNV 236 Query 243 ASGKDTRVRDIVEYVAD--KFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 A G+ T + ++ + D + I RPG+++ ADIS K +GF+P + +G+ Sbjct 237 ARGERTTILELAMKIIDATNSSSSIIFDKPRPGDIKHSQADISKIKKLGFKPDYSLKEGL 296 Query 301 DRYINWAKDQ 310 R I W + Q Sbjct 297 LRTIEWYRGQ 306 >gi|333911515|ref|YP_004485248.1| UDP-glucose 4-epimerase [Methanotorris igneus Kol 5] gi|333752104|gb|AEF97183.1| UDP-glucose 4-epimerase [Methanotorris igneus Kol 5] Length=305 Score = 181 bits (459), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 110/314 (36%), Positives = 177/314 (57%), Gaps = 19/314 (6%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 M+ILVTGGAGF GSH+ + L+ NGH V +LD N+ + +A F+ G +T+ Sbjct 1 MKILVTGGAGFIGSHIVDELIKNGHEVVILDNLVTGNKNNI-----NPKAEFVEGDITN- 54 Query 61 QTIDRAV--RDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYR-NRLIYV 117 + +D + +D VV H AA +NV +S+ DP + NV+GT +LE +RRY ++IY Sbjct 55 KNLDEKIDFQDIDVVIHQAAQINVRKSVEDPIYDGDVNVLGTLNILENMRRYDVKKIIYA 114 Query 118 STC-EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFN 176 S+ VYG+ L +DE+ + P SPYG SK + Y R YG++ I+R N Sbjct 115 SSGGAVYGEPEYLP----VDENHPIAPLSPYGLSKYCGEEYIKLYNRLYGIEYCILRYSN 170 Query 177 IFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLR 236 ++G RQ +I + + +N + IFG G+ TRD++YV D+ A + L + Sbjct 171 VYGERQDPRGEAGVISIFIDRILNNKNPIIFGDGNQTRDFVYVKDVARANLMAL---DWK 227 Query 237 GQAINFASGKDTRVRDIVEYVADKFGARIE--HRDARPGEVQRFPADISLAKSIGFQPQV 294 + +N +GK+T V ++ + +AD+ + + R GEV+R DI A+ +G++P+V Sbjct 228 NEIVNIGTGKETSVNELFKIIADELNYEDKPIYDKPREGEVRRIYLDIKKAEMLGWKPEV 287 Query 295 EIWDGIDRYINWAK 308 ++ +GI R +NW K Sbjct 288 DLKEGIKRVVNWMK 301 >gi|114565797|ref|YP_752951.1| nucleoside-diphosphate-sugar epimerase [Syntrophomonas wolfei subsp. wolfei str. Goettingen] gi|114336732|gb|ABI67580.1| nucleoside-diphosphate-sugar epimerase [Syntrophomonas wolfei subsp. wolfei str. Goettingen] Length=310 Score = 180 bits (457), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 111/310 (36%), Positives = 164/310 (53%), Gaps = 8/310 (2%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 M ILVTGGAGF G + + LLA G +T LD S + N+ FR + FI G + D Sbjct 1 MNILVTGGAGFIGRWVVKKLLAEGQRITALDDLSNGRLMNIDEFRDNPDFLFIEGDIKDR 60 Query 61 QTIDRAVRD-HHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVST 119 T+ + +V+HLAA +NV S+ DP + E +V GT+ VLE RR +++++ST Sbjct 61 DTLKQVFAGGFDLVYHLAASINVQDSIDDPRTTYENDVTGTFNVLEECRRQNIKMLFMST 120 Query 120 CEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG 179 C VY +L E +EH +KP SPY ASK A + L SY+ +YGL +VRPFN +G Sbjct 121 CMVYE--RSLDETGITEEHP-VKPASPYAASKLAGEALTLSYYYAYGLPTVVVRPFNTYG 177 Query 180 VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQA 239 QK+ G ++ +++ + GE L I+G G+ TRD LYV D R GQ Sbjct 178 PFQKSSGEGGVVAIFIQRELAGEELNIYGDGTQTRDLLYVEDCADFVVRAGRDSRANGQL 237 Query 240 INFASGKDTRVRDIVEYVADKFGARIEH-RDARP-GEVQRFPADISLAKS-IGFQPQVEI 296 +N G+D + + + G RI H P E+ + + A+ + +QP+V + Sbjct 238 LNAGLGRDVSINGLARMIGGDAG-RIRHVAHIHPQSEIPKLLCNYDKARELLDWQPRVSL 296 Query 297 WDGIDRYINW 306 +G+ R W Sbjct 297 EEGLQRTREW 306 >gi|343460113|gb|AEM38549.1| dTDP-glucose 4,6-dehydratase [Pyrolobus fumarii 1A] Length=332 Score = 180 bits (457), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 119/322 (37%), Positives = 176/322 (55%), Gaps = 26/322 (8%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRS-HDRAAFISGSVTD 59 M ++V GGAGF GS+ E L+ N VL ++ R DR F+ G + D Sbjct 1 MRVMVLGGAGFMGSNFVEFLVRNARRAEVLVYDKLTYAGRLENLRDVLDRIEFVKGDIVD 60 Query 60 ----GQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRL- 114 G+T+ R VV + AA +VD+S+ +P F+ TNV+G + VLE +R+YR+ L Sbjct 61 ERMLGETVQRF--KPEVVVNFAAETHVDRSINEPAPFIRTNVLGVFTVLEVLRKYRDALY 118 Query 115 IYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRP 174 +++ST EVYGD +E DE L+P+SPY ASKAA D +Y R+YG++ TIVRP Sbjct 119 VHISTDEVYGDLSWTQEMA--DETWCLRPSSPYSASKAAGDLFITAYGRTYGINYTIVRP 176 Query 175 FNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIV-GAYNLVLRTP 233 N +G RQ + LIPR + + + G+ TI+G G RD+LYV D G Y ++ + Sbjct 177 CNNYGPRQHPEK---LIPRTIIRLLLGKPATIYGDGGQVRDWLYVQDFAEGLYTVIKKGE 233 Query 234 TLRGQAI---NFASGKDTRVRDIVEYVADKFG----ARIEHRDARPGEVQRFPADISLAK 286 + I NFAS VR IVE + + G I + RPG+ +R+ + Sbjct 234 SHSIYNICAHNFAS-----VRQIVEMIVEMMGHDPSESIVYVRGRPGDDRRYAMKCDRVR 288 Query 287 SIGFQPQVEIWDGIDRYINWAK 308 S+G+ P+V++ +G+ R I W K Sbjct 289 SLGWTPRVDLREGLRRTIEWYK 310 >gi|345022444|ref|ZP_08786057.1| NAD-dependent epimerase/dehydratase [Ornithinibacillus sp. TW25] Length=315 Score = 180 bits (457), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 104/313 (34%), Positives = 167/313 (54%), Gaps = 8/313 (2%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSH-DRAAFISGSVTD 59 M+ L+TGGAGF G + +SLL +GH V VLD S N+ F +H + + G + D Sbjct 1 MKALLTGGAGFIGRWVVKSLLDDGHEVWVLDDFSNGRKENLADFGNHRNFKKLVIGDIKD 60 Query 60 GQTIDR--AVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYV 117 + ++ + + FHLAA +NV S+ P + +V+G + +LE +++ +L+++ Sbjct 61 TRLLNEIFTSNKYDICFHLAASINVQDSIERPTVTFQNDVIGAFNILEQCKKHHVKLVFM 120 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 STC VY N E +DE++ +KP SPY SK AA+ + SY+ +Y L VTI+RPFN Sbjct 121 STCMVYEQACN---EEGIDENSPVKPVSPYAGSKLAAENMVMSYYYAYDLPVTIIRPFNT 177 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRG 237 +G QK G G ++ ++ + + L I+G G+ TRD LYV D + G Sbjct 178 YGPYQKTGGEGGVVAIFIKNKLANKPLQIYGDGTQTRDLLYVEDCARFIVESGYSDKTNG 237 Query 238 QAINFASGKDTRVRDIVEYVADKFGARIEHRDARP-GEVQRFPADISLA-KSIGFQPQVE 295 + IN GKD + D+ + VA + G + P E+ + S A K +G++P+ Sbjct 238 EIINAGLGKDISINDLAKLVAGENGCIKHIKHIHPQSEISKLLCKYSKAQKLLGWEPKYS 297 Query 296 IWDGIDRYINWAK 308 + +GI + W K Sbjct 298 LEEGIKKTEEWIK 310 >gi|268680838|ref|YP_003305269.1| NAD-dependent epimerase/dehydratase [Sulfurospirillum deleyianum DSM 6946] gi|268618869|gb|ACZ13234.1| NAD-dependent epimerase/dehydratase [Sulfurospirillum deleyianum DSM 6946] Length=345 Score = 180 bits (456), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 111/321 (35%), Positives = 165/321 (52%), Gaps = 20/321 (6%) Query 4 LVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGF-----RSHDRAAFISGSVT 58 L+TGGAGF GS+ + ++ N+ F + R F GSVT Sbjct 6 LITGGAGFIGSNFLHYIFTTYPHSKIIVLDLLTYAGNVDNFPVRPNNNSGRFEFWYGSVT 65 Query 59 DGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRN---RLI 115 + ++ V +V H AA +V +S+ D +F ET+V+GT + AV + + R I Sbjct 66 NSALVEELVERADIVVHFAAETHVTRSIYDNRNFFETDVLGTQTIANAVLKNKKSVERFI 125 Query 116 YVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPF 175 ++ST EVYG N +DE L P SPY A+K ADRL YSY +Y + TI+RPF Sbjct 126 HISTSEVYGTAENCA---FMDEKHPLNPASPYAAAKVGADRLVYSYVNTYDIPATIIRPF 182 Query 176 NIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPT- 234 N +G RQ + IPR + + GE LT+ G G A+RD++YV D + +L P Sbjct 183 NNYGPRQHLEK---AIPRFITSLLLGEKLTVHGKGEASRDWIYVEDTCRGIDAILSAPID 239 Query 235 -LRGQAINFASGKDTRVRDIVEYVADKFGARIE---HRDARPGEVQRFPADIS-LAKSIG 289 ++G+ N + K +RD+ VA FG R E + + RPG+V ADIS + + +G Sbjct 240 KVKGEVFNLGTSKTISIRDVALRVAGLFGFREEKIIYNEDRPGQVDCHLADISKIERMLG 299 Query 290 FQPQVEIWDGIDRYINWAKDQ 310 + P+V +G+ I W K+ Sbjct 300 WTPKVTFEEGLQETIAWYKNN 320 >gi|18978160|ref|NP_579517.1| NDP-sugar dehydratase or epimerase [Pyrococcus furiosus DSM 3638] gi|18893965|gb|AAL81912.1| NDP-sugar dehydratase or epimerase [Pyrococcus furiosus DSM 3638] Length=307 Score = 179 bits (455), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 105/309 (34%), Positives = 167/309 (55%), Gaps = 15/309 (4%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNM-QGFRSHDRAAFISGSVTDGQ 61 ++VTGGAGF GSH+ E+L+ V V+D + N+ QG A FI + D Sbjct 6 VVVTGGAGFIGSHIAEALVEENE-VIVIDNLYSGKIENIPQG------AKFIEADIRDYS 58 Query 62 TIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCE 121 +I +R+ VFH AA ++V++S+ DP E NV+GT +L+A+ ++I+ S+ Sbjct 59 SIAEIIREADYVFHEAAQISVEESVRDPIFTDEVNVIGTLNILKALSEGSGKIIFASSAA 118 Query 122 VYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVR 181 VYG+ NL L E KP SPYG SK A + ++ YG+ I+R FN++G R Sbjct 119 VYGENKNLP----LKEDYLPKPISPYGVSKLAGEHYVRVFYELYGVPGVILRYFNVYGPR 174 Query 182 QKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAIN 241 Q + + +I ++ + E L IFG G TRD++YV D+V A LV G+ N Sbjct 175 QSSA-YAGVISIFMKNALKNEPLVIFGDGKQTRDFIYVKDVVQANLLVAEKERANGKIFN 233 Query 242 FASGKDTRVRDIVEYVAD--KFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDG 299 A+GK+T + ++ + D ++I RPG+++R ADI+ + +GF+P + +G Sbjct 234 VATGKETSILELALKIIDLTSSSSQILFAPERPGDIKRSVADINEIRKLGFEPSYSLEEG 293 Query 300 IDRYINWAK 308 + + W K Sbjct 294 LKETLEWFK 302 >gi|322372069|ref|ZP_08046611.1| NAD-dependent epimerase/dehydratase [Haladaptatus paucihalophilus DX253] gi|320548491|gb|EFW90163.1| NAD-dependent epimerase/dehydratase [Haladaptatus paucihalophilus DX253] Length=303 Score = 179 bits (455), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 106/301 (36%), Positives = 163/301 (55%), Gaps = 14/301 (4%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 +LVTGGAGF GSHL ++L+ V +LD S N+ ++ A I G + D +T Sbjct 10 VLVTGGAGFVGSHLVDALVQEND-VRILDDLSTGKRSNV-----NEEATLIEGDIRDSET 63 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEV 122 +DRA + ++FH A V+V QS+ +P E N+ T +LE R R++ S+C + Sbjct 64 LDRATENVDLIFHEAGVVSVQQSVEEPMRANEVNLDATLALLERARDLDARVVLASSCAI 123 Query 123 YGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQ 182 YG + + E P+SPYG K+A D Y YGL+ +R FNI+G RQ Sbjct 124 YGQPTEVP----ISEDESFSPSSPYGLQKSALDHYALLYEELYGLETVALRYFNIYGPRQ 179 Query 183 KAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINF 242 +G + +I RQ NG+ +T+ G G TRD+++V DIV A NL+ T G+A N Sbjct 180 SSGDYSGVISIFKRQATNGDPITVDGDGEQTRDFVHVDDIVRA-NLLAATTEHVGEAYNI 238 Query 243 ASGKDTRVRDIVEYVAD--KFGARIEHRDARPGEVQRFPADISLA-KSIGFQPQVEIWDG 299 +G +R++ E + D + I H D RPG++ ADIS A + +G++P + + +G Sbjct 239 GTGDSVTIRELAETIRDVSASSSDIVHTDPRPGDIDESEADISKATEKLGYEPTIPLDEG 298 Query 300 I 300 + Sbjct 299 L 299 >gi|253575887|ref|ZP_04853221.1| NAD-dependent epimerase/dehydratase [Paenibacillus sp. oral taxon 786 str. D14] gi|251844681|gb|EES72695.1| NAD-dependent epimerase/dehydratase [Paenibacillus sp. oral taxon 786 str. D14] Length=315 Score = 179 bits (455), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 102/314 (33%), Positives = 167/314 (54%), Gaps = 10/314 (3%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHD-RAAFISGSVTD 59 M IL+TGGAGF G + + LL +GH + +LD S N+Q F+ H FI G++ D Sbjct 1 MNILLTGGAGFIGRWVAKKLLEDGHQLWILDDLSNGREANLQEFQGHPGLKQFIRGTILD 60 Query 60 GQTIDRAVRDHH--VVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYV 117 ++ H + +HL A +NV S+ DP + + +GT+ +LE RRY +++++ Sbjct 61 EPLLEELFAAHQFDICYHLGASINVQDSIDDPRTTFNNDTVGTFYILEQCRRYNTKVVFM 120 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 STC VY + + E KP SPY +K AA+ + SY+ +YGL ++RPFN Sbjct 121 STCMVY---DRCTDETGITELHPTKPASPYAGAKVAAENMVLSYYYAYGLPTVVIRPFNT 177 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRG 237 +G QK G G ++ ++ ++G+ L I+G G+ TRD LYV D + + G Sbjct 178 YGPFQKTGGEGGVVAIFLKNDLDGKELRIYGEGTQTRDLLYVEDCANFVVSAGYSDAVNG 237 Query 238 QAINFASGKDTRVRDIVEYVADKFGARIEHRD-ARP-GEVQRFPADISLAKS-IGFQPQV 294 + +N G+D + D+ +A +RI H + P E+Q+ + AK +G++P+V Sbjct 238 EIVNAGLGRDITINDLALMIAGD-PSRIRHVEHIHPQSEIQKLLCNSEKAKRLLGWEPRV 296 Query 295 EIWDGIDRYINWAK 308 + +GI R W + Sbjct 297 TLEEGIARTREWIQ 310 >gi|153954706|ref|YP_001395471.1| nucleoside-diphosphate-sugar epimerase [Clostridium kluyveri DSM 555] gi|219855173|ref|YP_002472295.1| hypothetical protein CKR_1830 [Clostridium kluyveri NBRC 12016] gi|146347564|gb|EDK34100.1| Predicted nucleoside-diphosphate-sugar epimerase [Clostridium kluyveri DSM 555] gi|219568897|dbj|BAH06881.1| hypothetical protein [Clostridium kluyveri NBRC 12016] Length=335 Score = 179 bits (455), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 102/334 (31%), Positives = 169/334 (51%), Gaps = 35/334 (10%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 M LVTGGAGF G +T+ LL VTVLD S + N++ F+++ FI G + D Sbjct 1 MNTLVTGGAGFIGRWVTKRLLNENDSVTVLDNLSNGTLENIEEFKNNTHFKFIGGDIKDK 60 Query 61 QTIDRAVRDHH-VVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVR----------- 108 +D ++ +++HLAA +NV S+ DPE+ + +GT+ +LE R Sbjct 61 NKLDEVFKNKFDIIYHLAASINVQDSIDDPETTFFNDTLGTFNILEKARYQMFGKRGRMD 120 Query 109 -----------RYRNRLIYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRL 157 Y +++++STC VY ++ + E + E +KP SPYG SK AA+ + Sbjct 121 GNSWVLDPNEDTYPCKIVFMSTCMVY----DVSKDEGISETHPVKPVSPYGGSKIAAENM 176 Query 158 CYSYFRSYGLDVTIVRPFNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYL 217 SY+ +Y L ++RPFN +G QK G G ++ + ++G + I+G+G TRD L Sbjct 177 VLSYYNAYKLPAVVIRPFNTYGSFQKTGGEGGVVAIFINNVLHGRDINIYGSGEQTRDLL 236 Query 218 YVSDIVGAYNLVLRTPTLRGQAINFASGKDTRVRDIVEYVADKFGARIEHRDAR----PG 273 YV D + + GQ +N +G+D + ++ + + G++I+ + Sbjct 237 YVKDCADFVVESGYSEKVNGQIVNAGTGRDVTINELADIIC---GSKIKINHVKHIHPQS 293 Query 274 EVQRFPADISLAKS-IGFQPQVEIWDGIDRYINW 306 E+ + D S AK IG+QP+ + GI+ W Sbjct 294 EIMKLKCDYSKAKKLIGWQPKYTLEQGIEETRKW 327 >gi|328886045|emb|CCA59284.1| dTDP-glucose 4,6-dehydratase [Streptomyces venezuelae ATCC 10712] Length=322 Score = 179 bits (453), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 124/325 (39%), Positives = 176/325 (55%), Gaps = 22/325 (6%) Query 1 MEILVTGGAGFQGSHLTESLLANGH------WVTVLDKSSRNAVR-NMQGFRSHDRAAFI 53 M ILVTGGAGF GSH SLL + VTVLDK + R N+ SH+R F+ Sbjct 1 MRILVTGGAGFIGSHYVRSLLDGAYGGDGTDTVTVLDKLTYAGNRDNLPA--SHERLTFV 58 Query 54 SGSVTDGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLE-AVRRYRN 112 G + D + + H V H AA +VD+SL F+ TNV+GT VLE A+R Sbjct 59 RGDICDLPLLLDLLPGHDAVVHFAAESHVDRSLESAAEFVRTNVLGTQTVLEAALRTGVQ 118 Query 113 RLIYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIV 172 RL++VST EVYG + EG E L PNSPY ASKA++D + SY+R++GLD++I Sbjct 119 RLVHVSTDEVYG---TIDEGS-WTEDFPLLPNSPYAASKASSDLVARSYWRTHGLDLSIT 174 Query 173 RPFNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRT 232 R N +G Q + LIPR V + G + ++G G R++L+V D A +LVL T Sbjct 175 RCSNNYGPYQHPEK---LIPRFVTNLLEGHPVPVYGDGRNVREWLHVDDHCRAIHLVLTT 231 Query 233 PTLRGQAINFASGKDTRVRDIVEYVADKFGA---RIEHRDARPGEVQRFP-ADISLAKSI 288 G+ N SG + D+ E + D GA I + + R G R+ +D + + + Sbjct 232 GRA-GETYNIGSGNELTNLDLTERILDLCGADRSMIRYVEDRKGHDLRYSLSDAKIREEL 290 Query 289 GFQPQVEIWDGIDRYINWAKDQPQY 313 G+ P+ DG+ R ++W +D PQ+ Sbjct 291 GYTPRTSFEDGLRRTVDWYRDNPQW 315 >gi|171184952|ref|YP_001793871.1| dTDP-glucose 4,6-dehydratase [Thermoproteus neutrophilus V24Sta] gi|170934164|gb|ACB39425.1| dTDP-glucose 4,6-dehydratase [Thermoproteus neutrophilus V24Sta] Length=320 Score = 178 bits (451), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 112/316 (36%), Positives = 169/316 (54%), Gaps = 15/316 (4%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNA-VRNMQGFRSHDRAAFISGSVTD 59 M ++V GGAGF GS+ + G V V DK + + N++G F+ G V + Sbjct 1 MRVVVIGGAGFMGSNFVRHVAGRGE-VLVYDKLTYAGRLENLRGVEVE----FVRGDVAN 55 Query 60 GQTIDRAVRDHH--VVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYV 117 + + + VV + AA +VD+S+ DP FL TNV G Y VLEA RR +++ Sbjct 56 FELLFYVLSRFRPDVVVNFAAETHVDRSINDPAPFLTTNVWGVYSVLEAARRLGFLYVHI 115 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 ST EVYGD L G DE ++P+SPY ASKAA D L +Y R+YG+ IVRP N Sbjct 116 STDEVYGD---LAGGGEADESWPMRPSSPYSASKAAGDLLVQAYGRTYGVRFRIVRPCNN 172 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRG 237 +G Q + LIPR + + + G TI+G G RD+LYV D V A +V+ + G Sbjct 173 YGPFQHPEK---LIPRTIVRLLLGRPATIYGDGRQVRDWLYVGDFVRALEVVIER-GVDG 228 Query 238 QAINFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIW 297 N +G+ VR++VE +A G +++ RPGE R+ + +G++P+V + Sbjct 229 GIYNVCAGQPASVREVVERIASALGGSVKYVRGRPGEDMRYAMRCDRLRGLGWRPEVSLE 288 Query 298 DGIDRYINWAKDQPQY 313 +G+ R + W ++ + Sbjct 289 EGLRRTVEWYRENEWW 304 >gi|14591500|ref|NP_143580.1| UDP-glucose 4-epimerase [Pyrococcus horikoshii OT3] gi|3258173|dbj|BAA30856.1| 306aa long hypothetical UDP-glucose 4-epimerase [Pyrococcus horikoshii OT3] Length=306 Score = 178 bits (451), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 106/312 (34%), Positives = 166/312 (54%), Gaps = 13/312 (4%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 I++TGGAGF GSHL E+L + + V ++D + N+ + FI V D ++ Sbjct 6 IVITGGAGFIGSHLAEAL-KDENDVIIIDNLYSGRIENIP-----EGVKFIRADVRDYES 59 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEV 122 I + + VFH AA ++V +S+ DP E NV+GT VL A+ + +LI+ S+ V Sbjct 60 IAEVISEADYVFHEAAQISVKESIEDPVFTEEVNVIGTINVLRALSQGDGKLIFASSAAV 119 Query 123 YGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQ 182 YG+ L + E P SPYG +K AA+ C Y YG+ V I+R FN++G RQ Sbjct 120 YGEPKELP----ITEDTLTNPISPYGITKLAAEHYCRVYQSLYGIPVVILRYFNVYGPRQ 175 Query 183 KAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINF 242 + + +I + + I GE L IFG G TRD++YV D+V A LV + + G+ N Sbjct 176 SSA-YAGVISIFLERAIKGEPLIIFGDGKQTRDFIYVKDVVEANILVAKKRSANGRIFNV 234 Query 243 ASGKDTRVRDIVEYVAD--KFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 A+GK+T + ++ + D + I RPG+++R A I K +GF+P+ + +G+ Sbjct 235 ATGKETTILELAMKIIDMTSSSSSILFYPPRPGDIRRSVAKIERIKKLGFKPRYSLEEGL 294 Query 301 DRYINWAKDQPQ 312 W + Q Sbjct 295 KETFKWFTSRTQ 306 >gi|257052080|ref|YP_003129913.1| NAD-dependent epimerase/dehydratase [Halorhabdus utahensis DSM 12940] gi|256690843|gb|ACV11180.1| NAD-dependent epimerase/dehydratase [Halorhabdus utahensis DSM 12940] Length=306 Score = 177 bits (449), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 110/301 (37%), Positives = 165/301 (55%), Gaps = 14/301 (4%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 +L+TGGAGF GSHL ++L+ + + V VLD S N+ D A F+ G V D Sbjct 11 VLITGGAGFIGSHLADALVEH-NDVIVLDNLSTGKRENVP-----DGATFVEGDVRDADV 64 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEV 122 + ++FH AA V+V++S+ +P E N GT +LEA RR R+++ S+ + Sbjct 65 VADVSDGVDLIFHKAAVVSVERSIDEPAFSHEVNFDGTLTLLEAARRVDARVVFASSAAI 124 Query 123 YGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQ 182 YGD L + E + P SPYG K AAD+ +Y YGL+ +R FN +G RQ Sbjct 125 YGDPDTLP----ITESDPVDPQSPYGIDKCAADQYLRAYHDLYGLETVALRYFNAYGPRQ 180 Query 183 KAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINF 242 A + +I Q GE +T+ G G+ TRD+++VSD+V A NL+ T G A N Sbjct 181 TASDYSGVISIFGEQARAGEPITVNGDGTQTRDFVHVSDVVTA-NLLAATTEHVGTAYNI 239 Query 243 ASGKDTRVRDIVEYVADKFG--ARIEHRDARPGEVQRFPADISLAKS-IGFQPQVEIWDG 299 +G +T +R + E + G + I H D RPG++QR ADI+ A+ +G++P V + G Sbjct 240 GTGGETSIRSLAETIQATVGTDSPIVHGDPRPGDIQRSRADITTARERLGYEPSVPLETG 299 Query 300 I 300 + Sbjct 300 L 300 >gi|292670398|ref|ZP_06603824.1| NAD-dependent epimerase/dehydratase [Selenomonas noxia ATCC 43541] gi|292647990|gb|EFF65962.1| NAD-dependent epimerase/dehydratase [Selenomonas noxia ATCC 43541] Length=334 Score = 177 bits (449), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 109/303 (36%), Positives = 169/303 (56%), Gaps = 10/303 (3%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 LVTGGAGF GS+L E++L+ GH V VLD S V+N++GFR + + F+ G + D +T Sbjct 14 FLVTGGAGFIGSNLCEAILSMGHRVRVLDNLSSGYVKNIEGFRDNPKFEFVEGDIRDFRT 73 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRY-RNRLIYVSTCE 121 DR RD V H AA V+V +S+ P + TN+MGT ++EA + + Y S+ Sbjct 74 CDRVCRDVDYVLHHAADVSVPESIEKPLEYTITNIMGTVNMMEAAAKNGVKKFTYASSAA 133 Query 122 VYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVR 181 VYGD + + E + K S Y +K AA+ + Y YGLD +R FN++G R Sbjct 134 VYGDDETMLKREEIIG----KRLSTYAVTKFAAEEYAHQYTMYYGLDCYGMRYFNVYGRR 189 Query 182 QKA-GRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTP-TLRGQA 239 Q G + A+IP+ + + E TI G G +RD++YV D+V A L P + G+A Sbjct 190 QDPNGAYAAVIPKFIECLLRDEPPTINGDGEQSRDFVYVEDVVQANLLACAAPHEVAGEA 249 Query 240 INFASGKDTRVRDIVEYVADKFGARIE--HRDARPGEVQRFPADIS-LAKSIGFQPQVEI 296 N ASGK + + ++ ++D G ++ R G+++ ADIS ++K++G+ P+ + Sbjct 250 YNVASGKSSSLNEMYAVISDLLGKDLKPVFGPERKGDIRHSGADISKISKNLGYAPEYDF 309 Query 297 WDG 299 G Sbjct 310 ERG 312 >gi|296242301|ref|YP_003649788.1| dTDP-glucose 4,6-dehydratase [Thermosphaera aggregans DSM 11486] gi|296094885|gb|ADG90836.1| dTDP-glucose 4,6-dehydratase [Thermosphaera aggregans DSM 11486] Length=335 Score = 177 bits (448), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 119/319 (38%), Positives = 178/319 (56%), Gaps = 22/319 (6%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVL--DKSSRNA-VRNMQGFRSHDRAAFISGSV 57 M I V GGAGF GS+ L++N V VL DK + + N+ G + R FI G + Sbjct 1 MRIAVLGGAGFIGSNFVRYLVSNHEDVQVLVYDKLTYAGRLENLHGLLENKRLKFIRGDI 60 Query 58 TDGQTIDRAVRDHHV--VFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYR-NRL 114 + + ++ A+R+ + + AA +VD+S+ +P FL+TN+ G + +LE RR NRL Sbjct 61 CNEELLEHALREFQADAIVNFAAETHVDRSINNPAPFLQTNIYGVFTILEVSRRLDVNRL 120 Query 115 IYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRP 174 +++ST EVYGD + + EGE DE L P+SPY ASKA+ D L SY R+YGL + RP Sbjct 121 LHMSTDEVYGDLYGV-EGE-ADEKWPLNPSSPYSASKASGDLLIKSYGRTYGLKYILARP 178 Query 175 FNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPT 234 N +G Q + LIPR + + ++G+ TI+G GS RD+LYV D A L T Sbjct 179 SNNYGPYQHPEK---LIPRTIIRLLHGKPATIYGDGSQVRDWLYVEDTARA----LYTIL 231 Query 235 LRG---QAINFASGKDTRVRDIVEYVADKFG---AR-IEHRDARPGEVQRFPADISLAKS 287 RG + N + + VR+IV V + G AR I + RPGE +R+ + Sbjct 232 TRGGYQEVYNICASESATVREIVYRVVESMGRDPARDIVYVKGRPGEDRRYAMKCNKILG 291 Query 288 IGFQPQVEIWDGIDRYINW 306 +G++P V++ +G+ + I W Sbjct 292 LGWKPLVKLGEGLAKTIEW 310 >gi|57640939|ref|YP_183417.1| UDP-glucose 4-epimerase [Thermococcus kodakarensis KOD1] gi|57159263|dbj|BAD85193.1| UDP-glucose 4-epimerase [Thermococcus kodakarensis KOD1] Length=308 Score = 177 bits (448), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 102/312 (33%), Positives = 166/312 (54%), Gaps = 13/312 (4%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 ++VTGGAGF GSH+ L+ + V ++D N+ A + + D + Sbjct 7 VVVTGGAGFIGSHIAWELIKDND-VVIIDNLYTGKEENVP-----PGAKLVKADIRDYEA 60 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEV 122 I + + VFH AA V+V +S+ DP E NV+GT +++A+ +LI+ S+ V Sbjct 61 IAELISNADYVFHEAAQVSVVESIRDPVFTEEVNVLGTLNIIKALLEGHGKLIFASSAAV 120 Query 123 YGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQ 182 YGD NL L E +P SPYG +KA A+ + YGL V +R FN+FG RQ Sbjct 121 YGDNPNLP----LKETERPRPLSPYGVTKATAEEYLRVFHELYGLPVVSLRYFNVFGPRQ 176 Query 183 KAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINF 242 ++ +I + + + GE L IFG G TRD++YV D+V A LV + G+ N Sbjct 177 STNQYAGVISIFINRALKGEPLVIFGDGKQTRDFIYVKDVVKANLLVAESRKANGRVFNV 236 Query 243 ASGKDTRVRDIVEYVADKFG--ARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI 300 A+G++T + ++ + + G + + RPG+++ ADIS + +GF+P+ + +G+ Sbjct 237 ATGRETTILELAMKIIEITGTTSSVVFDKPRPGDIRHSRADISEIRKLGFEPEWSLEEGL 296 Query 301 DRYINW-AKDQP 311 + + W AK+ P Sbjct 297 KKTVEWYAKNNP 308 >gi|302874842|ref|YP_003843475.1| NAD-dependent epimerase/dehydratase [Clostridium cellulovorans 743B] gi|307690538|ref|ZP_07632984.1| NAD-dependent epimerase/dehydratase [Clostridium cellulovorans 743B] gi|302577699|gb|ADL51711.1| NAD-dependent epimerase/dehydratase [Clostridium cellulovorans 743B] Length=312 Score = 176 bits (447), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 97/306 (32%), Positives = 163/306 (54%), Gaps = 7/306 (2%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFR-SHDRAAFISGSVTD 59 M ILVTGGAGF G + + L + H + +LD + +++ N++ + ++ FI GS+ D Sbjct 1 MNILVTGGAGFIGRWVVKRLTEDNHNIWILDNLANSSIDNIKDLQFNYPNITFIEGSIMD 60 Query 60 GQTIDRA-VRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVS 118 ++ + + +HLAA +NV S+ DP++ E +V+GT+ VL+ + + +Y+S Sbjct 61 TNLLETLFINKFDICYHLAASINVQDSIDDPKTTFENDVIGTFNVLQQCKINNTKFVYMS 120 Query 119 TCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIF 178 TC VY N+ E + E P SPY A+K A + L SY+ +YGL T++RPFN + Sbjct 121 TCMVYSKALNI---EGISESHPTCPASPYAAAKLAGENLALSYYYAYGLPTTVLRPFNTY 177 Query 179 GVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQ 238 G QK G +I + + + + L I+G G TRD+LYV+D + G+ Sbjct 178 GPYQKQNSEGGVISIFIDKKLMNKPLAIYGDGKQTRDFLYVTDCADFVVEAGYSEKTNGK 237 Query 239 AINFASGKDTRVRDIVEYVADKFGARIEHRDARP-GEVQRFPADISLAKSI-GFQPQVEI 296 +N SG D + ++ + +A + G P E+Q+ D +K I G+ P+V + Sbjct 238 IVNAGSGVDISITELAKTIAGETGTIKYVTHIHPQSEIQKLLCDSRYSKKILGWSPKVSL 297 Query 297 WDGIDR 302 +GI + Sbjct 298 VEGISK 303 >gi|83589603|ref|YP_429612.1| NAD-dependent epimerase/dehydratase [Moorella thermoacetica ATCC 39073] gi|83572517|gb|ABC19069.1| NAD-dependent epimerase/dehydratase [Moorella thermoacetica ATCC 39073] Length=323 Score = 176 bits (446), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 112/319 (36%), Positives = 173/319 (55%), Gaps = 16/319 (5%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWV-TVLDKSSRNAVRNMQGFRSHDRAAFISGSVTD 59 M ILVTG GF GSHLTE L+ GH V + +SRN ++ D +G + D Sbjct 1 MHILVTGAGGFIGSHLTEKLVREGHKVRAFVHYNSRNTWGWLEESEVKDDIEVFTGDIRD 60 Query 60 GQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRY-RNRLIYVS 118 ++ ++R VVFHLAA + + S P ++++TNV GTY + +A R R+++ S Sbjct 61 YDSVRASLRGIEVVFHLAALIGIPYSYVTPVAYIKTNVEGTYNICQAAREEGLRRVVHTS 120 Query 119 TCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIF 178 T EVYG + +DE+ L+ SPY ASK AD+L S++RS+ L VTI+RPFN + Sbjct 121 TSEVYGTARYVP----IDENHPLQAQSPYAASKIGADQLALSFYRSFDLPVTIIRPFNTY 176 Query 179 GVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQ 238 G RQ A A+IP ++ Q ++G G + TRD+ +V D V + +P G+ Sbjct 177 GPRQSA---RAVIPTIITQLLSGREEIRLGNLAPTRDFNFVEDTVNGFITAGLSPHTVGE 233 Query 239 AINFASGKDTRVRDIVEYVADKFGARIEHR-DA---RP--GEVQRFPADISLAKSI-GFQ 291 +N SG++ + ++VE + G +++ R DA RP EV+R D A + G++ Sbjct 234 VVNIGSGREISIGELVELIGQLIGIKVKVRVDAERYRPEASEVERLCCDNRKANRLAGWR 293 Query 292 PQVEIWDGIDRYINWAKDQ 310 P+ + G+ I W K+ Sbjct 294 PEYSLSQGLAITIEWFKNH 312 >gi|340623550|ref|YP_004742003.1| dTDP-glucose 4,6-dehydratase [Methanococcus maripaludis XI] gi|339903818|gb|AEK19260.1| dTDP-glucose 4,6-dehydratase [Methanococcus maripaludis X1] Length=307 Score = 176 bits (446), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 109/318 (35%), Positives = 173/318 (55%), Gaps = 20/318 (6%) Query 1 MEILVTGGAGFQGSHLTESLLAN-GHWVTVLDKSSRNAVRNMQGFRS-HDRAAFISGSVT 58 M+ILVTGGAGF G + ++ N H +TVLD + N++ ++ FI G + Sbjct 1 MKILVTGGAGFIGCNFVRYMVQNYDHEITVLDNLTYAG--NLENLADVSEKIEFIKGDIC 58 Query 59 DGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRY-RNRLIYV 117 + + RA++D + H AA +VD S+ +PE+F++TN+ GTY +LE R++ ++ ++V Sbjct 59 SEEDVSRAMKDVDSIIHFAAESHVDNSIKNPENFVKTNIFGTYTLLEYARKFGIDKFLHV 118 Query 118 STCEVYGDGHN--LKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPF 175 ST EVYG KE +R+D P+SPY A+KA +D L +Y R+YGL+ I Sbjct 119 STDEVYGSTETGFFKEEDRVD------PSSPYSATKAGSDLLVNAYHRTYGLNTFITHCG 172 Query 176 NIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTL 235 N FG Q + LIP L+++ + E L I+G G RD++YV D ++V Sbjct 173 NNFGPYQYPEK---LIPVLIKKALKNEKLPIYGDGLNVRDWIYVEDHCTGIDMVFNKGNY 229 Query 236 RGQAINFASGKDTRVRDIVEYV---ADKFGARIEHRDARPGEVQRFPADISLAKSIGFQP 292 G+ N SG + +IV+++ DK + IE RPG +R+ D + +S+G+ P Sbjct 230 -GEVYNIGSGYEKTNLEIVKFILNELDKPESLIEFVKDRPGHDRRYALDSTKMRSLGWAP 288 Query 293 QVEIWDGIDRYINWAKDQ 310 + E + INW D+ Sbjct 289 KWEFEKALKYTINWYLDR 306 >gi|255523726|ref|ZP_05390692.1| NAD-dependent epimerase/dehydratase [Clostridium carboxidivorans P7] gi|296186730|ref|ZP_06855132.1| NAD-binding domain 4 [Clostridium carboxidivorans P7] gi|255512595|gb|EET88869.1| NAD-dependent epimerase/dehydratase [Clostridium carboxidivorans P7] gi|296048767|gb|EFG88199.1| NAD-binding domain 4 [Clostridium carboxidivorans P7] Length=335 Score = 176 bits (446), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 101/334 (31%), Positives = 167/334 (50%), Gaps = 31/334 (9%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 M ILVTGGAGF G + + LL +GH + LD S + N++ F+ + FI G + D Sbjct 1 MNILVTGGAGFIGRWVVKRLLEDGHQIVALDNLSNGRIENIEEFQGNKNFKFIKGDIKDE 60 Query 61 QTIDRAVRDHH-VVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVR----------- 108 +D R+ +V+HLAA +NV S+ DP + + +GT+ +LE + Sbjct 61 AVLDEIFREKFDIVYHLAASINVQDSIDDPRTTFYNDTIGTFNILEKAKIQMFGKNGRMD 120 Query 109 -----------RYRNRLIYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRL 157 Y +++++STC VY ++ +DE +KP SPYG SK AA+ + Sbjct 121 GDGWVLDSEEDTYPCKVVFMSTCMVY----DVAAEAGIDEKHPVKPVSPYGGSKIAAENM 176 Query 158 CYSYFRSYGLDVTIVRPFNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYL 217 SY+ +Y L ++RPFN +G QK G G ++ + I+G + I+G+G TRD L Sbjct 177 VLSYYNAYKLPTVVIRPFNTYGPFQKTGGEGGVVAIFINNSIHGRDINIYGSGEQTRDLL 236 Query 218 YVSDIVGAYNLVLRTPTLRGQAINFASGKDTRVRDIVEYVADKFGARIEH-RDARP-GEV 275 YV D + + + G IN +G+D + ++ E + K ++ H + P E+ Sbjct 237 YVKDCARFVVMSGYSQNVNGNIINAGTGRDVTINELAEIIT-KDRVKVNHVKHIHPQSEI 295 Query 276 QRFPADISLAKS-IGFQPQVEIWDGIDRYINWAK 308 + + + AK I ++P+ + GI+ W K Sbjct 296 MKLKCNYNKAKQLINWEPEYTLEQGIEETEQWIK 329 >gi|317130294|ref|YP_004096576.1| NAD-dependent epimerase/dehydratase [Bacillus cellulosilyticus DSM 2522] gi|315475242|gb|ADU31845.1| NAD-dependent epimerase/dehydratase [Bacillus cellulosilyticus DSM 2522] Length=316 Score = 176 bits (446), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 104/315 (34%), Positives = 173/315 (55%), Gaps = 16/315 (5%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSH-DRAAFISGSVTD 59 M +LVTGGAGF G + + LL +GH V VLD S +N+ F+ + + G + D Sbjct 1 MNVLVTGGAGFIGRWVVKHLLHDGHNVVVLDDLSNGQKKNLADFKDKSNLLEVVIGDIKD 60 Query 60 GQTIDRAVRDHH--VVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYV 117 Q +D + + +HL A +NV S+ DP + + +GT+ V+E R++ +++++ Sbjct 61 EQLLDSLFSKYSFDICYHLGASINVQDSIDDPRTTFNNDTVGTFYVMEQCRKHLVKVVFM 120 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 STC VY L E ++H KP SPY +K AA+ + SYF +Y L V +VRPFN Sbjct 121 STCMVYD--RCLDETGITEQHPT-KPASPYAGAKIAAENMVLSYFFAYDLPVVVVRPFNT 177 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLR---TPT 234 +G QK G G ++ +++ + GE L I+G G+ TRD L+V D N V++ + Sbjct 178 YGPFQKTGGEGGVVAIFIKKKLEGESLHIYGDGTQTRDLLFVEDCA---NFVVQAGYSEK 234 Query 235 LRGQAINFASGKDTRVRDIVEYVADKFGARIEHRD-ARP-GEVQRFPADISLAK-SIGFQ 291 + G+ IN G+D + D+ + + + RI+H + P E+Q+ ++ A +G++ Sbjct 235 VNGEVINAGLGRDISINDLAKLIVED-ENRIKHVEHIHPQSEIQKLLSNYEKAHLLLGWK 293 Query 292 PQVEIWDGIDRYINW 306 P+V + +GI R +W Sbjct 294 PKVSLEEGIKRTEDW 308 >gi|289191516|ref|YP_003457457.1| NAD-dependent epimerase/dehydratase [Methanocaldococcus sp. FS406-22] gi|288937966|gb|ADC68721.1| NAD-dependent epimerase/dehydratase [Methanocaldococcus sp. FS406-22] Length=301 Score = 176 bits (445), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 103/311 (34%), Positives = 173/311 (56%), Gaps = 18/311 (5%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 ILVTGGAGF GSH+ + L+ N + V +LD + + N+ + +A F++ + D + Sbjct 2 ILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGSKNNI-----NPKAEFVNADIRD-ED 55 Query 63 IDRAV--RDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYR-NRLIYVST 119 +D + +D VV H AA +NV S+ +P + NV+GT +LE +R+Y N++I+ S+ Sbjct 56 LDEKINFKDVEVVIHQAAQINVRNSVENPIYDGDINVLGTINILEMIRKYDINKIIFASS 115 Query 120 CEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG 179 VYG+ + L +DE+ + P SPYG SK + Y R YG++ I+R N++G Sbjct 116 VGVYGEPNYLP----VDENHTINPLSPYGLSKYVGEEYIKLYNRLYGIEYAILRYSNVYG 171 Query 180 VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQA 239 RQ +I + + + E IFG G+ TRD++YV D+ A + L + + Sbjct 172 ERQDPKGEAGVISIFIDKMLKNENPIIFGDGNQTRDFVYVGDVAKANIMAL---NWKNEI 228 Query 240 INFASGKDTRVRDIVEYVADKFGARIE--HRDARPGEVQRFPADISLAKSIGFQPQVEIW 297 +N +GK+T V ++ + D+ G + + R GE+ R +I AKS+ ++P+V++ Sbjct 229 VNIGTGKETSVNELFNIIKDEIGFKGNAIYDKPREGEIYRIYLNIKKAKSLDWRPEVDLK 288 Query 298 DGIDRYINWAK 308 +GI R +NW K Sbjct 289 EGIKRVVNWMK 299 >gi|335436900|ref|ZP_08559687.1| NAD-dependent epimerase/dehydratase [Halorhabdus tiamatea SARL4B] gi|334896973|gb|EGM35114.1| NAD-dependent epimerase/dehydratase [Halorhabdus tiamatea SARL4B] Length=306 Score = 176 bits (445), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 108/301 (36%), Positives = 166/301 (56%), Gaps = 14/301 (4%) Query 3 ILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQT 62 +L+TGGAGF GSHL ++L+A+ + V VLD S + N+ D A F+ G V D Sbjct 11 VLITGGAGFIGSHLADALVAD-NDVIVLDDLSSGSRENVP-----DGATFVEGDVRDEDI 64 Query 63 IDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEV 122 + +VFH AA V+V+QS+ +PE + N GT R+LEA RR RL++ S+ + Sbjct 65 VADVTDGVDLVFHEAAVVSVEQSIEEPEFCHDVNFDGTLRLLEAARRQDARLVFASSAAI 124 Query 123 YGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQ 182 YGD L + E P SPYG K AD+ +Y Y L+ +R FN++G RQ Sbjct 125 YGDPTTLP----ITESEPADPQSPYGIDKCGADQYVRTYHDLYDLETVALRYFNVYGPRQ 180 Query 183 KAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINF 242 A + +I Q G+ +T+ G G+ TRD+++V D+V A NL T G A N Sbjct 181 TASDYSGVISIFREQAQAGDPITVDGDGTQTRDFVHVRDVVQA-NLRAATTEHVGAAYNV 239 Query 243 ASGKDTRVRDIVEYVADKF--GARIEHRDARPGEVQRFPADISLAKS-IGFQPQVEIWDG 299 +G +T ++ + E + + G+ I H D RPG+++R AD++ A+ +G++ V + DG Sbjct 240 GTGDETSIQALAETIQETVDTGSSIVHGDPRPGDIERSRADVTKARQRLGYESDVSLADG 299 Query 300 I 300 + Sbjct 300 L 300 >gi|41033611|emb|CAF18472.1| dTDP-D-glucose-4,6-dehydratase [Thermoproteus tenax] Length=320 Score = 175 bits (444), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 110/316 (35%), Positives = 168/316 (54%), Gaps = 15/316 (4%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNA-VRNMQGFRSHDRAAFISGSVTD 59 M + V GGAGF GS+ + G V V DK + + N++G F+ G V + Sbjct 1 MRVAVIGGAGFMGSNFVRHMAGRGE-VLVYDKLTYAGRLENLRGVE----VEFVRGDVAN 55 Query 60 GQTIDRAVRDHH--VVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYV 117 + + + VV + AA +VD+S+ DP FL TNV G + VLEA R+ +++ Sbjct 56 FELLFYVLSRFRPDVVVNFAAETHVDRSINDPAPFLTTNVWGVHSVLEAARKLGFLYVHI 115 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 ST EVYGD L G DE ++P+SPY ASKAA D L +Y R+YG+ IVRP N Sbjct 116 STDEVYGD---LASGGEADESWPMRPSSPYSASKAAGDLLVQAYGRTYGVRFRIVRPCNN 172 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRG 237 +G Q + LIPR + + + G TI+G G RD+LYV D V A +V+ + G Sbjct 173 YGPFQHPEK---LIPRTIVRLLLGRPATIYGDGRQVRDWLYVGDFVRALEVVIER-GVDG 228 Query 238 QAINFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIW 297 N +G+ VR++VE +A G +++ RPGE R+ + +G++P+V + Sbjct 229 GIYNVCAGQPASVREVVERIASALGGSVKYVRGRPGEDMRYAMRCDKLRGLGWRPEVSLE 288 Query 298 DGIDRYINWAKDQPQY 313 +G+ R + W ++ + Sbjct 289 EGLRRTVEWYRENEWW 304 >gi|319789777|ref|YP_004151410.1| NAD-dependent epimerase/dehydratase [Thermovibrio ammonificans HB-1] gi|317114279|gb|ADU96769.1| NAD-dependent epimerase/dehydratase [Thermovibrio ammonificans HB-1] Length=314 Score = 175 bits (444), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 117/316 (38%), Positives = 173/316 (55%), Gaps = 21/316 (6%) Query 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60 M +LVTGGAGF GSHL E LL+ G V VLD S + N+ S + F+ GSVTD Sbjct 1 MSVLVTGGAGFIGSHLVEVLLSQGREVVVLDDLSTGKLSNLPDSSSLE---FVKGSVTDE 57 Query 61 QTIDRAVRDHHV--VFHLAAHVNVDQSLGDPESFLETNVMGTYRVLE-AVRRYRNRLIYV 117 + + R + + VFHLAA +V +S+ +P N GT +L+ AV R R I+ Sbjct 58 ELVRRLFEEFNFSSVFHLAAVASVQRSVEEPLYCHRVNCDGTLYLLQSAVSRGVKRFIFA 117 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 S+ VYGD L + E + + P +PY K A++R + FR YGL+ +R FN+ Sbjct 118 SSAAVYGDLPQLPKREEM----PVSPLTPYAVDKYASERYVVNSFRLYGLEGVALRFFNV 173 Query 178 FGVRQK-----AGRFGALIPRLVRQGINGEGLT--IFGAGSATRDYLYVSDIVGAYNLVL 230 FG RQ +G I R V++ + GE +T IFG G TRD++YV D+V A L+ Sbjct 174 FGERQDPSSPYSGVISIFIDR-VKRYLTGEPVTVDIFGDGRQTRDFIYVKDVVSAL-LIA 231 Query 231 RTPTLRGQAINFASGKDTRVRDIVEYVADKFGARIEHR--DARPGEVQRFPADISLAKSI 288 + G+ N +GK+T + ++++Y+ D G E R RPG+++R ADIS + + Sbjct 232 EERGVPGEVYNVGTGKETSLLELLDYIRDIVGTLPEIRFLPERPGDIKRSVADISKLEKL 291 Query 289 GFQPQVEIWDGIDRYI 304 GF P+ + +G+ I Sbjct 292 GFSPRFSVKEGLSNLI 307 >gi|344338020|ref|ZP_08768953.1| dTDP-glucose 4,6-dehydratase [Thiocapsa marina 5811] gi|343802074|gb|EGV20015.1| dTDP-glucose 4,6-dehydratase [Thiocapsa marina 5811] Length=332 Score = 175 bits (443), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 114/331 (35%), Positives = 172/331 (52%), Gaps = 42/331 (12%) Query 2 EILVTGGAGFQGSHLTESLLANGH---------------WVTVLDKSSRNAVRNMQGFRS 46 ++LVTG GF GSHLT++LLA+G W+ LDKS + M+ F Sbjct 7 KVLVTGADGFIGSHLTQALLAHGCSVRAFVYYNSFSSWGWLDALDKSQLD---TMEVF-- 61 Query 47 HDRAAFISGSVTDGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEA 106 +G + D + A++D VVFHLAA + + S P+S+++TN+ GT VL+A Sbjct 62 -------AGDIRDPNGVREAMKDCDVVFHLAALIGIPFSYHSPDSYVDTNIKGTLNVLQA 114 Query 107 VRRY-RNRLIYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSY 165 R+ RL+ ST EVYG + +DE+ L+ SPY A+K ADRL S++RS+ Sbjct 115 ARQLGVQRLVVTSTSEVYGTARYVP----IDENHPLQGQSPYSATKIGADRLAESFYRSF 170 Query 166 GLDVTIVRPFNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGA 225 V + RPFN +G RQ A ALIP ++ Q ++G+ G+ TRD+ YV+DI Sbjct 171 DTPVVVARPFNTYGPRQSA---RALIPTIITQLLSGDSDLKLGSTKPTRDFNYVTDITTG 227 Query 226 YNLVLRTPTLRGQAINFASGKDTRVRDIVEYVADKFGARI----EHRDARP--GEVQRFP 279 + + G+ +N A+G + V D+VE V G + E R RP EV R Sbjct 228 FLALAECDAAVGEEVNIATGTEYSVADVVEIVCKALGVVVSIDTEVRRLRPKNSEVSRLL 287 Query 280 ADISLAKSI-GFQPQVEIWDGIDRYINWAKD 309 D S + + G+QP+ G+ ++W ++ Sbjct 288 GDPSKMRELTGWQPEYSFERGLAETVDWFRN 318 >gi|334127350|ref|ZP_08501277.1| NAD-dependent epimerase/dehydratase [Centipeda periodontii DSM 2778] gi|333389703|gb|EGK60862.1| NAD-dependent epimerase/dehydratase [Centipeda periodontii DSM 2778] Length=324 Score = 175 bits (443), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 108/315 (35%), Positives = 169/315 (54%), Gaps = 14/315 (4%) Query 4 LVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQTI 63 L+TGGAGF GS+L E++L+ GH V VLD S N+ GFRS+ + FI G + D Sbjct 15 LITGGAGFIGSNLCEAILSMGHRVRVLDNLSTGYAENIAGFRSNPKFEFIEGDIRDADIC 74 Query 64 DRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYR-NRLIYVSTCEV 122 + V H AA V+V +S+ P + TN+MGT ++EA + + +Y S+ V Sbjct 75 NHVCDSVDYVLHHAAGVSVPESIEKPVDYTLTNIMGTVNMMEAAAKNSVKKFVYASSSAV 134 Query 123 YGDGHNLKEGERLDEHAELKPN--SPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV 180 YGD + + E E+ N S Y +K AA+ + Y YGLD +R FN++G Sbjct 135 YGDDETMPKRE------EIVGNRLSTYAVTKFAAEEYAHQYTMHYGLDCYGMRYFNVYGR 188 Query 181 RQKA-GRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTP-TLRGQ 238 RQ G + A+IP+ + + E TI G G +RD++YV D+V A L P G+ Sbjct 189 RQDPNGAYAAVIPKFIECLLRDEPPTIHGDGEQSRDFVYVEDVVQANLLACVAPHEAAGE 248 Query 239 AINFASGKDTRVRDIVEYVADKFGARIE--HRDARPGEVQRFPADIS-LAKSIGFQPQVE 295 A N ASGK + + ++ ++ G ++ R R G+++ ADIS + + +G++P+ + Sbjct 249 AYNVASGKRSSLNEMYTVLSKLLGKDLKPIFRSERKGDIRHSGADISKIREKLGYEPEYD 308 Query 296 IWDGIDRYINWAKDQ 310 +GI I W K++ Sbjct 309 FENGIKEAIQWYKEK 323 >gi|344330439|gb|EGW41734.1| short chain dehydrogenase family protein [Desulfosporosinus sp. OT] Length=336 Score = 174 bits (442), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 107/316 (34%), Positives = 174/316 (56%), Gaps = 19/316 (6%) Query 2 EILVTGGAGFQGSHLTESLLANGHWVTVLDK-SSRNAVRNMQGFRSH--DRAAFISGSVT 58 ++LVTG GF GSHLTE+L+ G V V + +SR+ N++ D+ FI+G + Sbjct 14 QVLVTGAGGFIGSHLTEALVKAGAKVRVFIRYNSRDGRGNLEDLEPKILDQIEFIAGDLR 73 Query 59 DGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRY-RNRLIYV 117 D I+R+V+ VFHL A V + S +P +ETN++GT+ +L A R + +R+++ Sbjct 74 DADVIERSVKGCDAVFHLGALVGIPYSYKNPREVVETNILGTFNILTAARDHGVSRVVHT 133 Query 118 STCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNI 177 ST EVYG + +DE L+ SPY ASK AD+L S++ S+ L V +RPFN Sbjct 134 STSEVYGSARYVP----IDEAHPLQGQSPYSASKIGADKLAESFYASFDLPVVTIRPFNC 189 Query 178 FGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRG 237 +G RQ A A+IP L+ Q + + + + G RD+ +V+D A+ ++ G Sbjct 190 YGPRQSA---RAVIPTLITQALACKEIRL-GNTDTLRDFTFVTDTAEAFMKAAQSQKADG 245 Query 238 QAINFASGKDTRVRDIVEYVADKFGAR----IEHRDARP--GEVQRFPADISLAK-SIGF 290 + IN SG++ + + + + + + ++ RP EV R AD LAK ++G+ Sbjct 246 KVINVGSGQEISIGQLAQVIINTLKSTAEIVVDEARVRPSKSEVTRLLADNRLAKETLGW 305 Query 291 QPQVEIWDGIDRYINW 306 +P+V + +GI R + W Sbjct 306 EPRVSLEEGIKRTVAW 321 Lambda K H 0.321 0.138 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 580252432782 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40