BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= ML0242
         (311 letters)

Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr;
Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr;
trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr;
Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr;
Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr;
Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr;
Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr;
Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr;
Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr;
Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr;
Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr;
Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 
           11,153,314 sequences; 3,808,957,724 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits)  Value

sp|Q9CD51|ISPE_MYCLE Tax_Id=1769 (ispE)RecName: Full=4-diphospho...   577   e-163
sp|B8ZU60|ISPE_MYCLB Tax_Id=561304 (ispE)RecName: Full=4-diphosp...   577   e-163
sp|P65178|ISPE_MYCTU Tax_Id=1773 (ispE)RecName: Full=4-diphospho...   483   e-135
sp|A5U154|ISPE_MYCTA Tax_Id=419947 (ispE)RecName: Full=4-diphosp...   483   e-135
sp|C1AM02|ISPE_MYCBT Tax_Id=561275 (ispE)RecName: Full=4-diphosp...   483   e-135
sp|A1KHE9|ISPE_MYCBP Tax_Id=410289 (ispE)RecName: Full=4-diphosp...   483   e-135
sp|P65179|ISPE_MYCBO Tax_Id=1765 (ispE)RecName: Full=4-diphospho...   483   e-135
tr|C6DVU2|C6DVU2_MYCTK Tax_Id=478434 SubName: Full=4-diphosphocy...   483   e-135
tr|A5WL34|A5WL34_MYCTF Tax_Id=336982 SubName: Full=4-diphosphocy...   483   e-135
tr|A4KFV1|A4KFV1_MYCTU Tax_Id=395095 SubName: Full=4-diphosphocy...   483   e-135
tr|A2VGU4|A2VGU4_MYCTU Tax_Id=348776 SubName: Full=4-diphosphocy...   482   e-134
sp|B2HDJ9|ISPE_MYCMM Tax_Id=216594 (ispE)RecName: Full=4-diphosp...   476   e-132
sp|A0PW69|ISPE_MYCUA Tax_Id=362242 (ispE)RecName: Full=4-diphosp...   475   e-132
sp|A0QBW1|ISPE_MYCA1 Tax_Id=243243 (ispE)RecName: Full=4-diphosp...   446   e-123
sp|Q741W1|ISPE_MYCPA Tax_Id=1770 (ispE)RecName: Full=4-diphospho...   444   e-123
sp|A4T6N7|ISPE_MYCGI Tax_Id=350054 (ispE)RecName: Full=4-diphosp...   419   e-115
sp|A1TEH2|ISPE_MYCVP Tax_Id=350058 (ispE)RecName: Full=4-diphosp...   416   e-114
sp|A0R3D7|ISPE_MYCS2 Tax_Id=246196 (ispE)RecName: Full=4-diphosp...   408   e-112
tr|Q1B417|Q1B417_MYCSS Tax_Id=164756 SubName: Full=4-diphosphocy...   407   e-112
tr|A3Q5H9|A3Q5H9_MYCSJ Tax_Id=164757 SubName: Full=4-diphosphocy...   407   e-112
tr|A1UL31|A1UL31_MYCSK Tax_Id=189918 SubName: Full=4-diphosphocy...   407   e-112
tr|B1MKD5|B1MKD5_MYCA9 Tax_Id=561007 SubName: Full=Probable 4-di...   404   e-111
tr|C1A375|C1A375_RHOE4 Tax_Id=234621 (ispE)SubName: Full=4-dipho...   346   2e-93
tr|C1AXZ7|C1AXZ7_RHOOB Tax_Id=632772 (ispE)SubName: Full=4-dipho...   345   3e-93
sp|Q0S4S3|ISPE_RHOSR Tax_Id=101510 (ispE)RecName: Full=4-diphosp...   345   4e-93
sp|Q5YPY8|ISPE_NOCFA Tax_Id=37329 (ispE)RecName: Full=4-diphosph...   342   4e-92
tr|C3JWT9|C3JWT9_RHOER Tax_Id=596309 (ispE)SubName: Full=4-(Cyti...   337   1e-90
tr|C2AMH2|C2AMH2_TSUPA Tax_Id=521096 SubName: Full=4-diphosphocy...   333   2e-89
tr|C7MZI6|C7MZI6_SACVD Tax_Id=471857 SubName: Full=4-diphosphocy...   330   1e-88
sp|A4F7X3|ISPE_SACEN Tax_Id=405948 (ispE)RecName: Full=4-diphosp...   328   5e-88
tr|C6WJI0|C6WJI0_ACTMD Tax_Id=446462 SubName: Full=4-diphosphocy...   325   5e-87
tr|D0L708|D0L708_9ACTO Tax_Id=526226 SubName: Full=4-diphosphocy...   297   9e-79
tr|A0LR96|A0LR96_ACIC1 Tax_Id=351607 SubName: Full=4-diphosphocy...   275   5e-72
tr|C8X6T6|C8X6T6_NAKMY Tax_Id=479431 SubName: Full=4-diphosphocy...   270   2e-70
tr|C7PYX1|C7PYX1_CATAD Tax_Id=479433 SubName: Full=4-diphosphocy...   269   3e-70
tr|C0U3M6|C0U3M6_9ACTO Tax_Id=526225 SubName: Full=4-diphosphocy...   269   3e-70
sp|A4X310|ISPE_SALTO Tax_Id=369723 (ispE)RecName: Full=4-diphosp...   264   1e-68
sp|A8M223|ISPE_SALAI Tax_Id=391037 (ispE)RecName: Full=4-diphosp...   264   1e-68
tr|C2A531|C2A531_THECU Tax_Id=471852 SubName: Full=4-diphosphocy...   257   1e-66
tr|C4E379|C4E379_STRRS Tax_Id=479432 SubName: Full=4-diphosphocy...   249   2e-64
tr|C1WFA2|C1WFA2_9ACTO Tax_Id=479435 SubName: Full=4-diphosphocy...   248   8e-64
tr|C9NG07|C9NG07_9ACTO Tax_Id=591167 SubName: Full=4-diphosphocy...   246   3e-63
tr|B5GPT9|B5GPT9_STRCL Tax_Id=443255 SubName: Full=4-diphosphocy...   246   3e-63
tr|A3TPV6|A3TPV6_9MICO Tax_Id=313589 SubName: Full=4-diphosphocy...   245   5e-63
tr|B5HBH1|B5HBH1_STRPR Tax_Id=457429 SubName: Full=4-diphosphocy...   242   5e-62
tr|C9YXY5|C9YXY5_STRSW Tax_Id=680198 SubName: Full=Putative isop...   239   3e-61
tr|B1VUG0|B1VUG0_STRGG Tax_Id=455632 SubName: Full=Putative 4-(C...   239   4e-61
tr|B5HKR8|B5HKR8_9ACTO Tax_Id=463191 SubName: Full=4-diphosphocy...   239   4e-61
sp|Q47SX2|ISPE_THEFY Tax_Id=269800 (ispE)RecName: Full=4-diphosp...   236   2e-60
sp|Q820G3|ISPE_STRAW Tax_Id=33903 (ispE)RecName: Full=4-diphosph...   236   3e-60

>sp|Q9CD51|ISPE_MYCLE Tax_Id=1769 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium leprae]
          Length = 311

 Score =  577 bits (1486), Expect = e-163
 Identities = 293/311 (94%), Positives = 293/311 (94%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG
Sbjct: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL
Sbjct: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA
Sbjct: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAPMSRGLNDM 311
           HAPMSRGLNDM
Sbjct: 301 HAPMSRGLNDM 311


>sp|B8ZU60|ISPE_MYCLB Tax_Id=561304 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium leprae]
          Length = 311

 Score =  577 bits (1486), Expect = e-163
 Identities = 293/311 (94%), Positives = 293/311 (94%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG
Sbjct: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL
Sbjct: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA
Sbjct: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAPMSRGLNDM 311
           HAPMSRGLNDM
Sbjct: 301 HAPMSRGLNDM 311


>sp|P65178|ISPE_MYCTU Tax_Id=1773 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium tuberculosis]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>sp|A5U154|ISPE_MYCTA Tax_Id=419947 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium tuberculosis]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>sp|C1AM02|ISPE_MYCBT Tax_Id=561275 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium bovis]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>sp|A1KHE9|ISPE_MYCBP Tax_Id=410289 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium bovis]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>sp|P65179|ISPE_MYCBO Tax_Id=1765 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium bovis]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>tr|C6DVU2|C6DVU2_MYCTK Tax_Id=478434 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>tr|A5WL34|A5WL34_MYCTF Tax_Id=336982 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>tr|A4KFV1|A4KFV1_MYCTU Tax_Id=395095 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis str. Haarlem]
          Length = 306

 Score =  483 bits (1244), Expect = e-135
 Identities = 247/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 SAP 303


>tr|A2VGU4|A2VGU4_MYCTU Tax_Id=348776 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis C]
          Length = 318

 Score =  482 bits (1240), Expect = e-134
 Identities = 246/303 (81%), Positives = 266/303 (87%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTGSVTV+VPGK+NLYLAVGD  ++GYHEL TVFHAVSLVD+VTVRNADVLSL LVGEG
Sbjct: 13  VPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 72

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 73  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 132

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFADS LL
Sbjct: 133 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 192

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T AVY E DRLR+VG+PPRL EPGPVLAAL A DP+QLAPLLGNE+QAAAVSLDPAL  A
Sbjct: 193 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 252

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC SA+SAIDVGAQL+GAGVCRTVRVATGPVPGARVV
Sbjct: 253 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 312

Query: 301 HAP 303
            AP
Sbjct: 313 SAP 315


>sp|B2HDJ9|ISPE_MYCMM Tax_Id=216594 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium marinum]
          Length = 307

 Score =  476 bits (1224), Expect = e-132
 Identities = 242/303 (79%), Positives = 263/303 (86%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGS TV+VPGK+NLYLAVGD  D+GYHEL TVFHAVSLVD+VTVRNAD+LSL +VGEG
Sbjct: 1   MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTD+ N+AW+AAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL+LPRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFA S L 
Sbjct: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           TPAV+TE DRLRDVG+PPRLAEPGPVLAAL A DPEQLAPLLGNE+QAAAVSLDPALR A
Sbjct: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC +A SA+DV AQL+GAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300

Query: 301 HAP 303
             P
Sbjct: 301 PTP 303


>sp|A0PW69|ISPE_MYCUA Tax_Id=362242 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium ulcerans]
          Length = 307

 Score =  475 bits (1222), Expect = e-132
 Identities = 242/303 (79%), Positives = 263/303 (86%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGS TV+VPGK+NLYLAVGD  D+GYHEL TVFHAVSLVD+VTVRNAD+LSL +VGEG
Sbjct: 1   MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTD+ N+AW+AAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADKLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL+LPRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFA S L 
Sbjct: 121 WELNLPRRDLRMLAAQLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           TPAV+TE DRLRDVG+PPRLAEPGPVLAAL A DPEQLAPLLGNE+QAAAVSLDPALR A
Sbjct: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC +A SA+DV AQL+GAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300

Query: 301 HAP 303
             P
Sbjct: 301 PTP 303


>sp|A0QBW1|ISPE_MYCA1 Tax_Id=243243 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium avium]
          Length = 306

 Score =  446 bits (1148), Expect = e-123
 Identities = 226/303 (74%), Positives = 254/303 (83%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           MPTGSVTV+VPGK+NLYLAVGD  ++GYHEL T+F AVSL+D+VTVRNADVLSL +VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTIFQAVSLLDEVTVRNADVLSLDIVGEG 60

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMAEHVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 61  ADKLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFAD  LL
Sbjct: 121 WELNVPRRDLRMLAAQLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADGELL 180

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T  V+ E DRLR  G+PPRL  PGPVLAAL A D +QLAPLLGNE+QAAAVSL+P LR  
Sbjct: 181 TRKVFAELDRLRRAGDPPRLPGPGPVLAALAAGDADQLAPLLGNEMQAAAVSLNPGLRRT 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG++AGALAGIVSGSGPTCAFLC SA +A+DVG +++G GVCRTVRVA+GPV GARVV
Sbjct: 241 LRAGVQAGALAGIVSGSGPTCAFLCPSAAAAVDVGTEVSGVGVCRTVRVASGPVAGARVV 300

Query: 301 HAP 303
            AP
Sbjct: 301 PAP 303


>sp|Q741W1|ISPE_MYCPA Tax_Id=1770 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium paratuberculosis]
          Length = 316

 Score =  444 bits (1142), Expect = e-123
 Identities = 224/303 (73%), Positives = 254/303 (83%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTGSVTV+VPGK+NLYLAVGD  ++GYHEL T+F AVSL+D+VTVRNADVLSL +VGEG
Sbjct: 11  VPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTIFQAVSLLDEVTVRNADVLSLDIVGEG 70

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AW+AAELMA+HVGRAPDVSIMIDKSIP                  MNSL
Sbjct: 71  ADKLPTDERNLAWQAAELMADHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 130

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL++PRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFAD  LL
Sbjct: 131 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADGELL 190

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           T  V+ E DRLR  G+PPRL  PGPVLAAL A D +QLAPLLGNE+QAAAVSL+P LR  
Sbjct: 191 TRKVFAELDRLRRAGDPPRLPGPGPVLAALAAGDADQLAPLLGNEMQAAAVSLNPGLRRT 250

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG++AGALAGIVSGSGPTCAFLC SA +A+DVG +++G GVCRTVRVA+GPV GARVV
Sbjct: 251 LRAGVQAGALAGIVSGSGPTCAFLCPSAAAAVDVGTEVSGVGVCRTVRVASGPVAGARVV 310

Query: 301 HAP 303
            AP
Sbjct: 311 PAP 313


>sp|A4T6N7|ISPE_MYCGI Tax_Id=350054 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium gilvum]
          Length = 322

 Score =  419 bits (1077), Expect = e-115
 Identities = 217/310 (70%), Positives = 245/310 (79%), Gaps = 3/310 (0%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTGSVTV+VPGK+NLYL VGD   +GYHEL TVFHAVSL+D+VTVR AD LSL  VGEG
Sbjct: 13  VPTGSVTVRVPGKVNLYLDVGDRRQDGYHELTTVFHAVSLLDEVTVRTADTLSLEHVGEG 72

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTDE N+AWRAAELMAEHVGRAPDV+I I+K+IP                  MNSL
Sbjct: 73  ADSLPTDERNLAWRAAELMAEHVGRAPDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSL 132

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL +PRRDL  LAA+LGSDVPFALHGGTALGTGRGEELATVL+R TFHWVLAF+   L 
Sbjct: 133 WELGVPRRDLHALAAQLGSDVPFALHGGTALGTGRGEELATVLTRNTFHWVLAFSPGGLS 192

Query: 181 TPAVYTEFDRLR---DVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPAL 237
           T  V+ E DRLR   D   PPRL  P PVLAAL + DP QLAPLLGN+LQ AA+SLDPAL
Sbjct: 193 TAKVFAEIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQLAPLLGNDLQPAALSLDPAL 252

Query: 238 RCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGA 297
           R  LRAG++AGALAG+VSGSGPTCAFLC SA +A+D+G  LAGAGVCRTVRVA+GPV GA
Sbjct: 253 RRTLRAGLDAGALAGLVSGSGPTCAFLCTSAGAAVDIGTDLAGAGVCRTVRVASGPVQGA 312

Query: 298 RVVHAPMSRG 307
           RVV AP + G
Sbjct: 313 RVVPAPSTAG 322


>sp|A1TEH2|ISPE_MYCVP Tax_Id=350058 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium vanbaalenii]
          Length = 322

 Score =  416 bits (1068), Expect = e-114
 Identities = 213/310 (68%), Positives = 245/310 (79%), Gaps = 3/310 (0%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTGSVTV+VPGK+NLYL VGD  D+GYHEL TVFHAVSL+D+VTVR AD+LSL + GEG
Sbjct: 13  VPTGSVTVRVPGKVNLYLDVGDRRDDGYHELTTVFHAVSLLDEVTVRTADILSLEMTGEG 72

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A  +PTDE N+AWRAAELMA+HVGR+PDV+I I+K+IP                  MNSL
Sbjct: 73  AESLPTDERNLAWRAAELMADHVGRSPDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSL 132

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL +PRRDL  LAA+LGSDVPFALHGGTALGTGRGEELATVL+R TFHWVLAF+   L 
Sbjct: 133 WELGVPRRDLHALAAQLGSDVPFALHGGTALGTGRGEELATVLTRNTFHWVLAFSPGGLS 192

Query: 181 TPAVYTEFDRLR---DVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPAL 237
           T  V+ E DRLR   D   PPRL  P PVLAAL + DP QLAPLLGN+LQ AA+SLD  L
Sbjct: 193 TAKVFAEIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQLAPLLGNDLQPAALSLDSTL 252

Query: 238 RCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGA 297
           R  LRAG++AGALAG+VSGSGPTCAFLC SA +A+DVG +LAGAGVCRTVRVA+GPV GA
Sbjct: 253 RRTLRAGVDAGALAGVVSGSGPTCAFLCGSAGAAVDVGTELAGAGVCRTVRVASGPVQGA 312

Query: 298 RVVHAPMSRG 307
           RVV +P + G
Sbjct: 313 RVVPSPSNAG 322


>sp|A0R3D7|ISPE_MYCS2 Tax_Id=246196 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium smegmatis]
          Length = 322

 Score =  408 bits (1048), Expect = e-112
 Identities = 212/303 (69%), Positives = 240/303 (79%), Gaps = 2/303 (0%)

Query: 3   TGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGAN 62
           TGSVTV+VPGK+NLYL+VGD  D+GYH+L TVFHAVSL+D+VTVRNADVLSL ++GEGA 
Sbjct: 17  TGSVTVRVPGKVNLYLSVGDLRDDGYHDLTTVFHAVSLLDEVTVRNADVLSLRMIGEGAE 76

Query: 63  HVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            +P DE N+AWRAAELMAEHVGRAPDV I I+KSIP                  MN+LWE
Sbjct: 77  SLPADERNLAWRAAELMAEHVGRAPDVEITIEKSIPVAGGMAGGSADAAGVLVAMNTLWE 136

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTP 182
           L +PRRDL  LAA+LGSDVPFALHGGTALG+GRGE+LATVL+R TFHWVLAFA   L TP
Sbjct: 137 LGVPRRDLHALAAQLGSDVPFALHGGTALGSGRGEDLATVLARNTFHWVLAFAHRGLSTP 196

Query: 183 AVYTEFDRLR--DVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
            V+ E DRLR       PR  EP PVLAAL + DP +LA LLGN+LQ AA+SL P LR  
Sbjct: 197 KVFGELDRLRADTTRGLPRTDEPEPVLAALASGDPAELAALLGNDLQPAALSLYPDLRRT 256

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLCASA +A+DVG QL+GAGVCRTVRVA+GPV GA VV
Sbjct: 257 LRAGVEAGALAGIVSGSGPTCAFLCASAPAALDVGTQLSGAGVCRTVRVASGPVHGAHVV 316

Query: 301 HAP 303
            AP
Sbjct: 317 PAP 319


>tr|Q1B417|Q1B417_MYCSS Tax_Id=164756 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Mycobacterium sp.]
          Length = 322

 Score =  407 bits (1046), Expect = e-112
 Identities = 209/308 (67%), Positives = 240/308 (77%), Gaps = 5/308 (1%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTGSVTV+VPGK+NL+L VGD  D+GYH+L TVFHAVSL+D+VTV  AD LSL L GEG
Sbjct: 11  VPTGSVTVRVPGKVNLFLGVGDLRDDGYHDLTTVFHAVSLLDEVTVSTADTLSLDLAGEG 70

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A  +PTD  N+AW+AAELMAEHVGR+PDV+I I+KSIP                  MN L
Sbjct: 71  AESLPTDRRNLAWKAAELMAEHVGRSPDVAISIEKSIPVAGGMAGGSADAAGVLVAMNHL 130

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WE+ +PRRDL  +AA+LGSDVPFALHGGTALGTGRGEELATVL+R+TFHWVLAFA   L 
Sbjct: 131 WEIGVPRRDLHAMAAELGSDVPFALHGGTALGTGRGEELATVLARSTFHWVLAFAYKGLS 190

Query: 181 TPAVYTEFDRLRDVGN-----PPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDP 235
           TP V+ E DRLR         P RL +P P+LAAL + D  QLAPLLGN+LQAAA+SL P
Sbjct: 191 TPKVFRELDRLRATAGAARAEPARLGDPEPMLAALASGDARQLAPLLGNDLQAAALSLSP 250

Query: 236 ALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVP 295
            LR  LRAG++AGALA IVSGSGPTCAFLCAS+  AIDVGA+LAGAGVCRTVRVA+GPV 
Sbjct: 251 DLRRTLRAGLDAGALAAIVSGSGPTCAFLCASSPQAIDVGARLAGAGVCRTVRVASGPVQ 310

Query: 296 GARVVHAP 303
           GARVV AP
Sbjct: 311 GARVVPAP 318


>tr|A3Q5H9|A3Q5H9_MYCSJ Tax_Id=164757 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-erythritol
           kinase;[Mycobacterium sp.]
          Length = 322

 Score =  407 bits (1046), Expect = e-112
 Identities = 209/308 (67%), Positives = 240/308 (77%), Gaps = 5/308 (1%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTGSVTV+VPGK+NL+L VGD  D+GYH+L TVFHAVSL+D+VTV  AD LSL L GEG
Sbjct: 11  VPTGSVTVRVPGKVNLFLGVGDLRDDGYHDLTTVFHAVSLLDEVTVSTADTLSLDLAGEG 70

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A  +PTD  N+AW+AAELMAEHVGR+PDV+I I+KSIP                  MN L
Sbjct: 71  AESLPTDRRNLAWKAAELMAEHVGRSPDVAISIEKSIPVAGGMAGGSADAAGVLVAMNHL 130

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WE+ +PRRDL  +AA+LGSDVPFALHGGTALGTGRGEELATVL+R+TFHWVLAFA   L 
Sbjct: 131 WEIGVPRRDLHAMAAELGSDVPFALHGGTALGTGRGEELATVLARSTFHWVLAFAYKGLS 190

Query: 181 TPAVYTEFDRLRDVGN-----PPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDP 235
           TP V+ E DRLR         P RL +P P+LAAL + D  QLAPLLGN+LQAAA+SL P
Sbjct: 191 TPKVFRELDRLRATAGAARAEPARLGDPEPMLAALASGDARQLAPLLGNDLQAAALSLSP 250

Query: 236 ALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVP 295
            LR  LRAG++AGALA IVSGSGPTCAFLCAS+  AIDVGA+LAGAGVCRTVRVA+GPV 
Sbjct: 251 DLRRTLRAGLDAGALAAIVSGSGPTCAFLCASSPQAIDVGARLAGAGVCRTVRVASGPVQ 310

Query: 296 GARVVHAP 303
           GARVV AP
Sbjct: 311 GARVVPAP 318


>tr|A1UL31|A1UL31_MYCSK Tax_Id=189918 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Mycobacterium sp.]
          Length = 322

 Score =  407 bits (1046), Expect = e-112
 Identities = 209/308 (67%), Positives = 240/308 (77%), Gaps = 5/308 (1%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTGSVTV+VPGK+NL+L VGD  D+GYH+L TVFHAVSL+D+VTV  AD LSL L GEG
Sbjct: 11  VPTGSVTVRVPGKVNLFLGVGDLRDDGYHDLTTVFHAVSLLDEVTVSTADTLSLDLAGEG 70

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A  +PTD  N+AW+AAELMAEHVGR+PDV+I I+KSIP                  MN L
Sbjct: 71  AESLPTDRRNLAWKAAELMAEHVGRSPDVAISIEKSIPVAGGMAGGSADAAGVLVAMNHL 130

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WE+ +PRRDL  +AA+LGSDVPFALHGGTALGTGRGEELATVL+R+TFHWVLAFA   L 
Sbjct: 131 WEIGVPRRDLHAMAAELGSDVPFALHGGTALGTGRGEELATVLARSTFHWVLAFAYKGLS 190

Query: 181 TPAVYTEFDRLRDVGN-----PPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDP 235
           TP V+ E DRLR         P RL +P P+LAAL + D  QLAPLLGN+LQAAA+SL P
Sbjct: 191 TPKVFRELDRLRATAGAARAEPARLGDPEPMLAALASGDARQLAPLLGNDLQAAALSLSP 250

Query: 236 ALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVP 295
            LR  LRAG++AGALA IVSGSGPTCAFLCAS+  AIDVGA+LAGAGVCRTVRVA+GPV 
Sbjct: 251 DLRRTLRAGLDAGALAAIVSGSGPTCAFLCASSPQAIDVGARLAGAGVCRTVRVASGPVQ 310

Query: 296 GARVVHAP 303
           GARVV AP
Sbjct: 311 GARVVPAP 318


>tr|B1MKD5|B1MKD5_MYCA9 Tax_Id=561007 SubName: Full=Probable
           4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Mycobacterium abscessus]
          Length = 314

 Score =  404 bits (1037), Expect = e-111
 Identities = 205/300 (68%), Positives = 233/300 (77%)

Query: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           +PTG+VTV+ PGK+NLYLAVGD  D+GYHEL TVFHAVSL D VTVR+ADVLS+ +VG+G
Sbjct: 9   VPTGAVTVRAPGKVNLYLAVGDLRDDGYHELTTVFHAVSLADDVTVRDADVLSIDVVGQG 68

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
              VPTDE N+AW+AAEL A+HVGRAPDVSI I+K IP                  MN L
Sbjct: 69  EGTVPTDERNLAWQAAELFADHVGRAPDVSIFINKDIPVAGGMAGGSADAAAVLVAMNEL 128

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           W   +PRRDL  LAA+LGSDVPFALHGGTALGTGRGE+LATVL+R  FHWV AFAD  L 
Sbjct: 129 WHAGVPRRDLHHLAAQLGSDVPFALHGGTALGTGRGEQLATVLARNVFHWVFAFADGGLA 188

Query: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           TP V+ E DRLR+ G+PPRLAE   +L AL A D  +LAPLLGNELQAAAVSL+P LR  
Sbjct: 189 TPQVFKEIDRLRENGDPPRLAEADELLGALAAGDARRLAPLLGNELQAAAVSLNPELRRT 248

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           LRAG  AGALAGIVSGSGPTCAFLC SA  A+ V A+LAGAGVCRTVRVA+GPV GA+V+
Sbjct: 249 LRAGESAGALAGIVSGSGPTCAFLCTSADDAVQVSAELAGAGVCRTVRVASGPVHGAQVI 308


>tr|C1A375|C1A375_RHOE4 Tax_Id=234621 (ispE)SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Rhodococcus erythropolis]
          Length = 331

 Score =  346 bits (887), Expect = 2e-93
 Identities = 177/295 (60%), Positives = 213/295 (72%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           V V+ P K+NL+LAVGD  D+GYHEL TVF A+SL D VTV  AD L++ ++G+ A  VP
Sbjct: 29  VVVRAPSKVNLHLAVGDLRDDGYHELTTVFQALSLADTVTVAPADTLTVRVIGDDAAAVP 88

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
           TD  N+ WRAAE++A   G AP+V I+I+K IP                  +NSLW+L  
Sbjct: 89  TDRANLVWRAAEMLAAEGGVAPNVEIVIEKGIPVAGGMAGGSADAAAALVALNSLWKLDF 148

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
            R DL   AA+LGSDVPF+LHGGTALGTGRGE+L  VL+R TFHWVLA A   L TP V+
Sbjct: 149 SRPDLDAFAARLGSDVPFSLHGGTALGTGRGEQLVPVLTRRTFHWVLALAKGGLSTPVVF 208

Query: 186 TEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 245
            E D+LR  G P RL     ++ AL   DP  LAPLLGN+LQAAA+SL+P LR  LRAG+
Sbjct: 209 RELDKLRAEGTPNRLGTADELIHALTTGDPHVLAPLLGNDLQAAALSLNPDLRRTLRAGV 268

Query: 246 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           EAGALAGIVSGSGPTCAFLCA A SA++V A+LAGAGVCRTVRVA+GPVPGAR++
Sbjct: 269 EAGALAGIVSGSGPTCAFLCADAQSAVEVSAELAGAGVCRTVRVASGPVPGARIL 323


>tr|C1AXZ7|C1AXZ7_RHOOB Tax_Id=632772 (ispE)SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Rhodococcus opacus]
          Length = 311

 Score =  345 bits (886), Expect = 3e-93
 Identities = 178/296 (60%), Positives = 213/296 (71%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           V V+ P K+NL+LAVGD  D+GYHEL TVF A+SL D V+V  A+ LS+ + GE A  VP
Sbjct: 9   VVVRAPSKVNLHLAVGDLRDDGYHELKTVFQALSLGDTVSVVPAETLSVKVRGEDARVVP 68

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
           TD  N+ W+AAE++A   GR PDV I IDK IP                  +N+LW+L L
Sbjct: 69  TDSRNLVWQAAEMLAAESGRRPDVEIAIDKGIPVAGGMAGGSADAAATLVGLNALWQLDL 128

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
            R +L   AAKLGSDVPF+LHGGTA+GTGRGE L  VLSR+TFHWVLA A   L TP V+
Sbjct: 129 SREELDGFAAKLGSDVPFSLHGGTAVGTGRGERLLPVLSRSTFHWVLALAKGGLSTPTVF 188

Query: 186 TEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 245
            E DRLR  GNPPRL  P  ++ AL   D   LAPLLGN+LQ+AA+SL+P LR  LRAG+
Sbjct: 189 RELDRLRADGNPPRLGGPEDLMHALTTGDAATLAPLLGNDLQSAALSLNPGLRRTLRAGV 248

Query: 246 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVH 301
            AGALAGIVSGSGPTCAFLCA A +A+ V A+LAGAGVCRTVRVA+GPVPGAR+++
Sbjct: 249 AAGALAGIVSGSGPTCAFLCADADAAVRVSAELAGAGVCRTVRVASGPVPGARIIN 304


>sp|Q0S4S3|ISPE_RHOSR Tax_Id=101510 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Rhodococcus sp.]
          Length = 311

 Score =  345 bits (885), Expect = 4e-93
 Identities = 178/296 (60%), Positives = 213/296 (71%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           V V+ P K+NL+LAVGD  D+GYHEL TVF A+SL D V+V  A+ LS+ + GE A  VP
Sbjct: 9   VVVRAPSKVNLHLAVGDLRDDGYHELNTVFQALSLSDTVSVAPAETLSVTVRGEDARVVP 68

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
           TD  N+ W+AAE++A   GR PDV I IDK IP                  +N+LW+L L
Sbjct: 69  TDSSNLVWQAAEMLAAESGRRPDVEIAIDKGIPVAGGMAGGSADAAATLVGLNALWQLDL 128

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
            R +L   AAKLGSDVPF+LHGGTA+GTGRGE L  VLSR+TFHWVLA A   L TP V+
Sbjct: 129 SREELDGFAAKLGSDVPFSLHGGTAVGTGRGERLLPVLSRSTFHWVLALAKVGLSTPTVF 188

Query: 186 TEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 245
            E DRLR  GNPPRL  P  ++ AL   D   LAPLLGN+LQ+AA+SL+P LR  LRAG+
Sbjct: 189 RELDRLRADGNPPRLGGPEDLMHALTTGDAATLAPLLGNDLQSAALSLNPGLRRTLRAGV 248

Query: 246 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVH 301
            AGALAGIVSGSGPTCAFLCA A +A+ V A+LAGAGVCRTVRVA+GPVPGAR+++
Sbjct: 249 AAGALAGIVSGSGPTCAFLCAEADAAVRVSAELAGAGVCRTVRVASGPVPGARIIN 304


>sp|Q5YPY8|ISPE_NOCFA Tax_Id=37329 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Nocardia farcinica]
          Length = 307

 Score =  342 bits (876), Expect = 4e-92
 Identities = 176/295 (59%), Positives = 212/295 (71%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           V V+ P K+NL+L VGD   +GYH+L TVF A+SL D + +  A  L++ + GEGA  VP
Sbjct: 9   VLVRAPSKVNLHLGVGDLRPDGYHDLTTVFQALSLGDDLRISPASALTVKVNGEGAAEVP 68

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
           TD  N+ W+AA  +A  VGRAP V I+IDK IP                  +N LW++ L
Sbjct: 69  TDRTNLVWKAAVRLAHLVGRAPLVEIVIDKGIPVAGGMAGGSADAAAALVGLNELWDMGL 128

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
            R +L  LAA+LGSDVPFALHGGTALGTGRGE L  VLSR TFHWVLAFA   L TPAV+
Sbjct: 129 GRDELSALAAELGSDVPFALHGGTALGTGRGERLLPVLSRNTFHWVLAFAKGGLSTPAVF 188

Query: 186 TEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 245
            E DRLR+ G+PPRL +P  ++ AL + DP QLAPLLGN+LQAAAVSL P LR  LRAG+
Sbjct: 189 AELDRLREHGDPPRLGDPQALMQALASGDPAQLAPLLGNDLQAAAVSLKPELRRTLRAGV 248

Query: 246 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
            AGALAG+VSGSGPTCAFLC SA +A+ V A+LAGAGV R+VR A+GPVPGARV+
Sbjct: 249 TAGALAGLVSGSGPTCAFLCESADAAVAVAAELAGAGVARSVRTASGPVPGARVI 303


>tr|C3JWT9|C3JWT9_RHOER Tax_Id=596309 (ispE)SubName:
           Full=4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol
           kinase; EC=2.7.1.148;[Rhodococcus erythropolis SK121]
          Length = 315

 Score =  337 bits (864), Expect = 1e-90
 Identities = 172/295 (58%), Positives = 212/295 (71%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           V V+ P K+NL+LAVGD  D+GYHEL TVF A+SL D +TV  AD L++ ++G+ A  VP
Sbjct: 13  VVVRAPSKVNLHLAVGDLRDDGYHELTTVFQALSLADTLTVTPADTLTVRVIGDDAAAVP 72

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
           TD  N+ WRAAE++A   G AP+V I+I+K IP                  +N+LW+L  
Sbjct: 73  TDRTNLVWRAAEMLAVEGGVAPNVEIVIEKGIPVAGGMAGGSADAAAALVALNALWKLDF 132

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
            R DL   AA+LGSDVPF+LHGGTALGTGRGE+L  VL+R TFHWVLA A   L TP V+
Sbjct: 133 SRPDLDAFAARLGSDVPFSLHGGTALGTGRGEQLVPVLTRHTFHWVLALAKGGLSTPVVF 192

Query: 186 TEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 245
            E D+LR  G+P R+     ++ AL   D   LA LLGN+LQAAA+SL+P LR  LRAG+
Sbjct: 193 RELDKLRAEGSPKRVGSADALIQALTTGDAHLLASLLGNDLQAAALSLNPDLRRTLRAGV 252

Query: 246 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           EAGALAGIVSGSGPTCAFLCA A SA++V A+LAGAGVCRTVRVA+GPVPGAR++
Sbjct: 253 EAGALAGIVSGSGPTCAFLCADAQSAVEVSAELAGAGVCRTVRVASGPVPGARIL 307


>tr|C2AMH2|C2AMH2_TSUPA Tax_Id=521096 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Tsukamurella paurometabola DSM 20162]
          Length = 304

 Score =  333 bits (854), Expect = 2e-89
 Identities = 174/296 (58%), Positives = 207/296 (69%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           S+TV+ P K+NL+L VGD   +G+HEL TVF A+SL D+V++  AD LSL + GEGA  V
Sbjct: 8   SLTVRAPAKVNLHLGVGDVRPDGFHELQTVFQALSLHDEVSLARADELSLHVSGEGARDV 67

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           PTD  N+A RA   +AE  G  P V I I K IP                    +LW L 
Sbjct: 68  PTDSTNLAARAVAALAERYGLDPAVRIEIAKGIPVAGGMAGGSADAAAALLGAATLWHLD 127

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
           L R +L  +AA LGSDVPF+LHGGTALGTGRGE+L   LSR  FHW LA A   L TPAV
Sbjct: 128 LSRSELDEIAATLGSDVPFSLHGGTALGTGRGEQLIPALSRGEFHWTLALAREGLSTPAV 187

Query: 185 YTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAG 244
           Y E DRLR+ G+PPR   P  +LAA+ + DP +LAPLL N+LQAAA+SL P LR  LRAG
Sbjct: 188 YRELDRLREAGDPPRAGSPDDLLAAVASGDPNRLAPLLANDLQAAALSLQPGLRRTLRAG 247

Query: 245 MEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           MEAGALAGIVSGSGPTCAFLC +  SA++VG++LAGAGVCRTVRVA+GPVPGA V+
Sbjct: 248 MEAGALAGIVSGSGPTCAFLCINGESAVEVGSELAGAGVCRTVRVASGPVPGAEVL 303


>tr|C7MZI6|C7MZI6_SACVD Tax_Id=471857 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Saccharomonospora viridis]
          Length = 308

 Score =  330 bits (846), Expect = 1e-88
 Identities = 177/297 (59%), Positives = 208/297 (70%), Gaps = 3/297 (1%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           VTV+VP KINL+L+VGD  D+GYHEL TVF A+SL D+VT        + + GEGA  VP
Sbjct: 9   VTVRVPSKINLHLSVGDVRDDGYHELTTVFQALSLTDEVTALAGGDSGVEVSGEGARSVP 68

Query: 66  TDEHNIAWRAAELMAEHVGR---APDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            +E N+A RA   +AEHVGR   A  V ++I K IP                   + LW 
Sbjct: 69  KNEDNLAVRAVRALAEHVGRPERAERVRLVIRKGIPVAGGMAGGSADAAGALLACSILWG 128

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTP 182
           L L R +L  +AA LGSDVPFAL+GGTALGTGRGE+L  VLSR TFHWVLAF    L TP
Sbjct: 129 LDLHRDELAEVAATLGSDVPFALYGGTALGTGRGEQLVPVLSRHTFHWVLAFDQRGLSTP 188

Query: 183 AVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALR 242
            VY E DRLR+ G+PPR+  P  +L AL + DP +LAPLLGN+LQAAA+SL P LR  LR
Sbjct: 189 KVYGELDRLREAGDPPRVGAPEALLEALASGDPHRLAPLLGNDLQAAAISLRPGLRRTLR 248

Query: 243 AGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARV 299
           AG+ AGALAG+VSGSGPTCAFLC+ A SA+ V A+LAGAGVCRTVRVA GPVPGARV
Sbjct: 249 AGVTAGALAGVVSGSGPTCAFLCSDADSALKVAAELAGAGVCRTVRVAHGPVPGARV 305


>sp|A4F7X3|ISPE_SACEN Tax_Id=405948 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Saccharopolyspora erythraea]
          Length = 318

 Score =  328 bits (841), Expect = 5e-88
 Identities = 171/298 (57%), Positives = 210/298 (70%), Gaps = 3/298 (1%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           +TV+VP K+NL+L+VGD  ++GYHELVTVF A+S+ D+VTV  AD   + + GEGA+ VP
Sbjct: 6   ITVRVPAKVNLHLSVGDTREDGYHELVTVFQALSMTDEVTVHIADEPGIEVRGEGADSVP 65

Query: 66  TDEHNIAWRAAELMAEHVGRAPD---VSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
           T   N+AW+A   +AE  GR PD   V + I+K IP                  +N LW 
Sbjct: 66  TGPSNLAWKAVRALAERCGRDPDEPGVRVSINKGIPVAGGMAGGSADAAAALLALNHLWR 125

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTP 182
           L + R +L  +AA +GSDVPFAL GGTALGTGRGE+L  VL+R TFHWV+A     L TP
Sbjct: 126 LEMGRDELAGIAADIGSDVPFALQGGTALGTGRGEQLIPVLARHTFHWVIALDRRGLETP 185

Query: 183 AVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALR 242
            V++E DRLR+   P R+ E  PVL AL + DP QLA LLGN+LQAAAVSL P LR  LR
Sbjct: 186 GVFSELDRLREESRPNRVGEVEPVLEALASGDPRQLALLLGNDLQAAAVSLRPGLRRTLR 245

Query: 243 AGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           AG++AGALAGIVSGSGPTCAFLC  A +A+ V A+L+GAGVCRTVRVA GPVPGAR+V
Sbjct: 246 AGVQAGALAGIVSGSGPTCAFLCTDADAAVRVAAELSGAGVCRTVRVAQGPVPGARLV 303


>tr|C6WJI0|C6WJI0_ACTMD Tax_Id=446462 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Actinosynnema mirum]
          Length = 321

 Score =  325 bits (832), Expect = 5e-87
 Identities = 172/303 (56%), Positives = 209/303 (68%), Gaps = 3/303 (0%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           VTV+VP K+NL+LAVGD  D+GYH+LVT+F A+SL D+VTV  +D   + + GEGA  VP
Sbjct: 9   VTVRVPAKVNLHLAVGDLRDDGYHDLVTIFQALSLTDEVTVGASDDPGVEVRGEGAESVP 68

Query: 66  TDEHNIAWRAAELMAEHVGRAPD---VSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
           TD  N+AW+A  ++AEH GR P+   V + I K+IP                  + +LW+
Sbjct: 69  TDPSNLAWKAVRVLAEHTGRDPEDVKVRVGIRKAIPVAGGMAGGSADAAATLVALAALWK 128

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTP 182
           L   R +L  LA ++G+DVPFAL+GGTALGT RG+ L  VL +  FHWVLAF    L TP
Sbjct: 129 LDTTRDELAELAGRIGADVPFALYGGTALGTDRGDRLVPVLGKHPFHWVLAFDKQGLSTP 188

Query: 183 AVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALR 242
            V+ E DRLR  GNPPR+ E   VL  L + DP QLA LLGN+LQAAAVSL P LR  LR
Sbjct: 189 EVFRELDRLRAEGNPPRVGEAEAVLEGLSSGDPRQLALLLGNDLQAAAVSLRPNLRRTLR 248

Query: 243 AGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHA 302
           AG+ AGALAG+VSGSGPTCAFLC    +A+ V A+LAGAGVCRTVRVA GPVPGARVV A
Sbjct: 249 AGVNAGALAGMVSGSGPTCAFLCEDGDTAVRVAAELAGAGVCRTVRVAQGPVPGARVVGA 308

Query: 303 PMS 305
             S
Sbjct: 309 EES 311


>tr|D0L708|D0L708_9ACTO Tax_Id=526226 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Gordonia bronchialis DSM 43247]
          Length = 315

 Score =  297 bits (761), Expect = 9e-79
 Identities = 161/301 (53%), Positives = 200/301 (66%), Gaps = 5/301 (1%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           SVT + P K+NL+L VG    +GYH+LVTVF A+SL D V V     L++ + GEGA+ V
Sbjct: 12  SVTARAPSKVNLHLGVGPRRPDGYHDLVTVFQALSLHDDVRVSPGTDLTVSVRGEGASAV 71

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D  N+A RA + +AE  GR+P  +I IDKSIP                    ++W+L 
Sbjct: 72  PDDSSNLAARAVQALAEWCGRSPVAAIDIDKSIPVAGGMAGGSADAAAALVAAAAMWKLD 131

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
           + R DL  +AA LGSDVPFALHG TALGTGRGE+L +VLSR  FHWVLA A   L TP V
Sbjct: 132 VDRDDLSDIAAGLGSDVPFALHGATALGTGRGEQLISVLSRGEFHWVLALAREGLSTPQV 191

Query: 185 YTEFDRLRDVGNPPRLAE-----PGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRC 239
           Y E DRLRD  +   + +     P  ++ AL A DP  +APLL N+LQ AA+SL PALR 
Sbjct: 192 YAELDRLRDNRSDDAMTDDPLRRPDDLMQALAAGDPRAVAPLLHNDLQPAALSLQPALRR 251

Query: 240 ALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARV 299
            LRAG++AGAL GIVSGSGPTCAFLC    SA++V A+L+GAGV R+VR A+GPVPG RV
Sbjct: 252 TLRAGVDAGALNGIVSGSGPTCAFLCLDEGSAVNVAAELSGAGVARSVRTASGPVPGTRV 311

Query: 300 V 300
           +
Sbjct: 312 I 312


>tr|A0LR96|A0LR96_ACIC1 Tax_Id=351607 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Acidothermus cellulolyticus]
          Length = 332

 Score =  275 bits (703), Expect = 5e-72
 Identities = 154/304 (50%), Positives = 191/304 (62%), Gaps = 8/304 (2%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           SVTVQ   KINLYL VG    +GYH+L TVFHAVSL D++TV  ++ LSL + GE A  V
Sbjct: 24  SVTVQASAKINLYLRVGPLRSDGYHDLATVFHAVSLHDEITVEESEHLSLEICGEQAEKV 83

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D  N+A RAA L+A  +GR P V I++ K IP                    +LW   
Sbjct: 84  PLDGDNLAVRAAMLLARRLGREPGVRIVLRKGIPVAGGMAGGSADAAATLIACAALWHAE 143

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
           LP  +L  LAA+LGSDVPF + GGTALG GRGE LA VL+   ++WVLA AD  L TP V
Sbjct: 144 LPHDELMTLAAQLGSDVPFCVVGGTALGHGRGERLAPVLAAGPWYWVLALADGGLSTPQV 203

Query: 185 YTEFDR--------LRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPA 236
           Y EFDR        LR+ G+   L  P  +L+AL   DP++L  LL N+LQ AAV+L PA
Sbjct: 204 YAEFDRRRASGDGELREPGDGEPLDVPAALLSALRDGDPKRLGSLLHNDLQDAAVALRPA 263

Query: 237 LRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPG 296
           L   L AG++ GAL GIV GSGPTCAFL +   +A+D+ A+LAG+G  R VR ATGP  G
Sbjct: 264 LGRVLEAGLDGGALGGIVCGSGPTCAFLVSDQDAAVDLAARLAGSGWVRAVRCATGPAAG 323

Query: 297 ARVV 300
           AR++
Sbjct: 324 ARIL 327


>tr|C8X6T6|C8X6T6_NAKMY Tax_Id=479431 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Nakamurella multipartita]
          Length = 317

 Score =  270 bits (689), Expect = 2e-70
 Identities = 154/301 (51%), Positives = 192/301 (63%), Gaps = 4/301 (1%)

Query: 2   PTG-SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60
           P G SV V+ P KINLYLAVGD  ++GYH+LVTVF AV L D++TVR A   ++      
Sbjct: 13  PAGPSVRVRAPAKINLYLAVGDVREDGYHDLVTVFQAVDLADELTVRPARRSAVRTTPPD 72

Query: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
              VP    N+A  AA L+A        V+I I K IP                    +L
Sbjct: 73  G--VPVGAKNLAGVAARLLATRTKSGGPVAIDIAKQIPVAGGMAGGSADAAAALVGCAAL 130

Query: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180
           WEL + R++L  +  ++G+DVPFAL GGTALGTGRG+ L+ V++RA  HWVLA AD  L 
Sbjct: 131 WELRVQRQELIEIGREIGADVPFALAGGTALGTGRGDLLSPVMTRARLHWVLAIADHGLS 190

Query: 181 TPAVYTEFDRLR-DVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRC 239
           TPAV+ E DRLR   G PP +     +LAAL + +P ++A  LGN+LQAAA+SL P LR 
Sbjct: 191 TPAVFAELDRLRAQGGGPPPVRPVDTMLAALTSGEPAKIAAALGNDLQAAAISLAPGLRR 250

Query: 240 ALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARV 299
            LRAG +AGAL G+VSGSGPT A LCA A SA  V A+LAG+G CR+VRVA GP PGARV
Sbjct: 251 TLRAGEQAGALGGLVSGSGPTVALLCADAESAGAVAAELAGSGTCRSVRVAAGPAPGARV 310

Query: 300 V 300
           +
Sbjct: 311 L 311


>tr|C7PYX1|C7PYX1_CATAD Tax_Id=479433 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Catenulispora acidiphila]
          Length = 316

 Score =  269 bits (688), Expect = 3e-70
 Identities = 152/301 (50%), Positives = 184/301 (61%), Gaps = 4/301 (1%)

Query: 3   TGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGAN 62
           T SVTV+VP K+NL L+VG    +GYH+L TVFHAV L D+V    AD L++   GEG  
Sbjct: 17  TESVTVRVPAKVNLALSVGPLRSDGYHDLATVFHAVGLFDEVNAAAADTLAVTCEGEGQV 76

Query: 63  HVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            VP D+ N+AWRAAEL+A  VGR+P V + + K IP                   ++LW 
Sbjct: 77  EVPLDDTNLAWRAAELLARTVGRSPGVRLHLTKGIPVAGGMAGGSADAAGALVACDALWG 136

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTP 182
             L R DL +LAA+LGSDVPFALHGGTA+GTGRGE++  VL+R  FHWV AFA   L TP
Sbjct: 137 TGLSRDDLHVLAAQLGSDVPFALHGGTAMGTGRGEQITPVLARGEFHWVFAFAHDGLSTP 196

Query: 183 AVYTEFDRLRDVGNPPRLAEPG---PVLAALVAADPEQLAPLLGNELQAAAVSLDPALRC 239
           AV+ E DRLR+       A PG    +L AL A D   L   L N+L   A SL P LR 
Sbjct: 197 AVFHELDRLREAAGEEATA-PGVEDELLRALRAGDSTLLGAALRNDLTRPATSLRPDLRA 255

Query: 240 ALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARV 299
            L+AG EAGAL  ++SGSGPTCAFL A A +A  V A L  A   R VR A GP  GA +
Sbjct: 256 TLQAGREAGALGTLLSGSGPTCAFLAADAVAAATVAAALEAAPSVRAVRRALGPAAGAHL 315

Query: 300 V 300
           +
Sbjct: 316 L 316


>tr|C0U3M6|C0U3M6_9ACTO Tax_Id=526225 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Geodermatophilus obscurus DSM 43160]
          Length = 321

 Score =  269 bits (688), Expect = 3e-70
 Identities = 155/305 (50%), Positives = 188/305 (61%), Gaps = 8/305 (2%)

Query: 4   GSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGA-- 61
           G+V  + P K+N++LAVG    +G+HEL TV+ AVSL D VTVR  D LSL + GEG   
Sbjct: 16  GAVVARAPAKVNVHLAVGPLRSDGFHELRTVYLAVSLFDTVTVRPGDGLSLTVTGEGTTG 75

Query: 62  ---NHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMN 118
              + VPTD  N+ WRAAEL+AE  G   D +I IDKSIP                  ++
Sbjct: 76  SGPDAVPTDRRNLVWRAAELLAERAGVPADAAITIDKSIPAAAGLAGGSADAAAALVALD 135

Query: 119 SLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSS 178
           +LW     R +L  LAA+LGSDVPF+L GG ALG+GRGE+L+ VL+R  + WVL  A   
Sbjct: 136 ALWATHATRGELTALAARLGSDVPFSLLGGVALGSGRGEQLSPVLARRRWDWVLGIAGEG 195

Query: 179 LLTPAVYTEFDRLRDVGNPP---RLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDP 235
           L TPAVY E DRLR  G  P    L+ P PV+AAL +     LA  LGN+LQ  A+SL P
Sbjct: 196 LSTPAVYAELDRLRAAGRVPDGEELSSPDPVIAALRSGPVPALAAALGNDLQPPALSLRP 255

Query: 236 ALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVP 295
            LR ALRA   AGA A +VSGSGPT A L     SA+ + A LAG GV RTVR   GPVP
Sbjct: 256 DLRRALRAATGAGAAAAVVSGSGPTVAALAEDEESAVRLTAALAGEGVYRTVRAVHGPVP 315

Query: 296 GARVV 300
           GAR+V
Sbjct: 316 GARLV 320


>sp|A4X310|ISPE_SALTO Tax_Id=369723 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Salinispora tropica]
          Length = 315

 Score =  264 bits (674), Expect = 1e-68
 Identities = 147/299 (49%), Positives = 182/299 (60%), Gaps = 2/299 (0%)

Query: 3   TGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGAN 62
           +G V V+VP KINL+L VG    +GYHEL TV+HA+S+ D++T R  D L+L + GEGA 
Sbjct: 16  SGPVRVRVPAKINLHLGVGPLRRDGYHELNTVYHAISIHDELTARRGDTLTLTMEGEGAG 75

Query: 63  HVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            +  DE N+  RAA  +A   G  P   + + K IP                   ++LW 
Sbjct: 76  ELALDESNLVIRAARALAGSTGVPPHARLHLRKQIPLAGGLAGGSADAAAALVACDALWG 135

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRAT-FHWVLAFADSSLLT 181
             L R +L  +AA LGSDVPF +HGGTALGTGRGE ++ VL+R T +HWV+A AD  L T
Sbjct: 136 TGLTRDELAEIAAGLGSDVPFLIHGGTALGTGRGEAVSPVLARPTVWHWVVAVADGGLST 195

Query: 182 PAVYTEFDRLRDVGNP-PRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           P  Y E DRLR  G   P L     +LAAL   DP  LA  LGN+LQ AA++L PAL   
Sbjct: 196 PVAYRELDRLRAAGAAGPPLGSTDTLLAALRQPDPRVLAAALGNDLQDAALALRPALAAT 255

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARV 299
           L+AG  AGALAGIVSGSGPTC FL A A  A  + A+L+   VCR  R A GPV GAR+
Sbjct: 256 LKAGEAAGALAGIVSGSGPTCVFLAAGAADAERIAAELSALDVCRQARTAHGPVAGARI 314


>sp|A8M223|ISPE_SALAI Tax_Id=391037 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Salinispora arenicola]
          Length = 315

 Score =  264 bits (674), Expect = 1e-68
 Identities = 146/299 (48%), Positives = 183/299 (61%), Gaps = 2/299 (0%)

Query: 3   TGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGAN 62
           +G   V+VP KINL+L VG    +GYHEL TV+HA+S+ D++T R  D L+L + GEGA 
Sbjct: 16  SGPFRVRVPAKINLHLGVGPLRPDGYHELNTVYHAISIHDELTARRGDTLALTMEGEGAG 75

Query: 63  HVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            +  D+ N+  RAA  +A H G  P   + + K IP                   ++LW 
Sbjct: 76  ELALDDSNLVIRAARALAAHAGVPPYARLHLRKQIPLAGGLAGGSADAAAALVACDALWG 135

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRAT-FHWVLAFADSSLLT 181
             L R +L  +AA LGSDVPF +HGGTALGTGRGE ++ VL+R T +HWV+A AD  L T
Sbjct: 136 TGLSRDELAGIAADLGSDVPFLIHGGTALGTGRGEAVSPVLARPTVWHWVVAVADGGLST 195

Query: 182 PAVYTEFDRLRDVGNPPR-LAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           P  Y E DRLRD G     L     +LAAL   DP  LA +LGN+LQ AA++L P+L   
Sbjct: 196 PVAYRELDRLRDAGAASTPLGSSDALLAALRQRDPRVLAGVLGNDLQDAALALRPSLAAT 255

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARV 299
           L+AG  AGALAGIVSGSGPTC FL A+A  A  V  +L+   VCR  R A GPV GARV
Sbjct: 256 LKAGEAAGALAGIVSGSGPTCVFLAANAADAERVAGELSALDVCRQARTARGPVAGARV 314


>tr|C2A531|C2A531_THECU Tax_Id=471852 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Thermomonospora curvata DSM 43183]
          Length = 298

 Score =  257 bits (656), Expect = 1e-66
 Identities = 152/299 (50%), Positives = 182/299 (60%), Gaps = 8/299 (2%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           +TV+VP K+NL LAVG    +GYH+LV VFHAVSL D+VT   AD L++ + GE    VP
Sbjct: 1   MTVRVPAKVNLQLAVGPLRADGYHDLVNVFHAVSLFDEVTAEPADELTVTVRGESVEGVP 60

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
             E N+A RAA L+AE +G  PDV++ I K+IP                     LW+ S 
Sbjct: 61  VGEDNLAARAARLLAERIGARPDVALTIHKTIPVAGGMAGGSADAAAALVACARLWDASG 120

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
            R  L  LAA LGSDVPFAL GGTA+GTGRGE L  V     FHWV A AD  L TPAVY
Sbjct: 121 VR--LADLAADLGSDVPFALLGGTAIGTGRGEVLTPVPVGGRFHWVFALADGGLSTPAVY 178

Query: 186 TEFDRLRDVG----NPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCAL 241
            E DRLR+       PPR ++   +L AL   D E L   L N+LQ AA+SL P+LR  L
Sbjct: 179 AECDRLREAAGQRVGPPRRSQ--ALLDALERGDAEALGAALANDLQPAALSLRPSLRRTL 236

Query: 242 RAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           +AG E GAL  +VSGSGPTCAFL  SA  A ++ A L+ AG+ R    A GPVPGA VV
Sbjct: 237 QAGREGGALGALVSGSGPTCAFLARSAGHAAELAAALSEAGLVRAAVSAHGPVPGATVV 295


>tr|C4E379|C4E379_STRRS Tax_Id=479432 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Streptosporangium roseum DSM 43021]
          Length = 300

 Score =  249 bits (637), Expect = 2e-64
 Identities = 146/300 (48%), Positives = 178/300 (59%), Gaps = 6/300 (2%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           SVTV+VP K+NL LAVG   D+GYH+LV VFHAVS+ D+VT      +S+ + GE A+ V
Sbjct: 3   SVTVRVPAKVNLQLAVGPLRDDGYHDLVNVFHAVSIFDEVTATAETGMSVRVEGESADQV 62

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D+ N+A RAA  +A H GR+  V+++I K+IP                   N LW L 
Sbjct: 63  PEDDDNLAIRAALALARHAGRSYGVNLIIRKAIPVAGGMAGGSADAAAALVACNELWGLG 122

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
           LP  DL  +AA LGSDVPFAL GGTA+GTGRGE L  +     FHWV A AD  L T  V
Sbjct: 123 LPVEDLMEIAADLGSDVPFALLGGTAVGTGRGERLTPLEVGGRFHWVFALADGGLSTAKV 182

Query: 185 YTEFDRLRDVGNP----PRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240
           Y E DR+R+        PR A+  P+LAAL   D + L   L N+LQ AAV L  +L   
Sbjct: 183 YAECDRMREATGEEIAWPRAAD--PLLAALRRGDAKALGSELANDLQPAAVMLRRSLART 240

Query: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           L AG E GA+  +VSGSGPTCAFL  S   A ++   L  AGV R V  A GPVPG  VV
Sbjct: 241 LEAGREQGAVGTLVSGSGPTCAFLAESEAHAGELALSLKAAGVARDVITAYGPVPGPTVV 300


>tr|C1WFA2|C1WFA2_9ACTO Tax_Id=479435 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Kribbella flavida DSM 17836]
          Length = 311

 Score =  248 bits (632), Expect = 8e-64
 Identities = 145/311 (46%), Positives = 190/311 (61%), Gaps = 10/311 (3%)

Query: 2   PTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVT--VRNADVLSLGLVGE 59
           P+  VTV+ P KINL L+VG    +G+H L TV+ AV+L D VT  VR+   +++ +VG+
Sbjct: 5   PSAQVTVRSPAKINLGLSVGPPRPDGFHPLATVYQAVALYDDVTATVRDDAEVTVEVVGD 64

Query: 60  GANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNS 119
            A +VPTD+ N+A RAA L+         V + I K+IP                   N 
Sbjct: 65  FAVNVPTDDSNLAVRAARLLQAEYDVEEGVDLSIRKTIPVAGGMAGGSTDAAATLVACNR 124

Query: 120 LWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSL 179
           LW L L + +L  LAA+LGSDVPF L G TALG GRGE +  V+SR TFHWV A AD  L
Sbjct: 125 LWGLQLTQSELQHLAAELGSDVPFCLVGHTALGQGRGEHVTEVMSRGTFHWVFAIADGGL 184

Query: 180 LTPAVYTEFDRLRDVGNPPRLAEPGPV----LAALVAADPEQLAPLLGNELQAAAVSLDP 235
            TP VY E DR+R    P R  EP  V    LAAL++     LA  + N+LQAAA+SL P
Sbjct: 185 STPEVYAELDRIR----PLRRVEPPEVRPELLAALLSGRSAALAVAISNDLQAAALSLRP 240

Query: 236 ALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVP 295
            L   L+ G++ GALA ++SGSGPTC FL A +  A+D+  +LA +G+CR VR A GPVP
Sbjct: 241 ELGDTLQFGLDQGALAAMISGSGPTCLFLAADSRRAVDLAVELAESGLCRMVRQAEGPVP 300

Query: 296 GARVVHAPMSR 306
           GAR++ A ++R
Sbjct: 301 GARILPANVNR 311


>tr|C9NG07|C9NG07_9ACTO Tax_Id=591167 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-erythritol
           kinase;[Streptomyces flavogriseus ATCC 33331]
          Length = 299

 Score =  246 bits (627), Expect = 3e-63
 Identities = 147/298 (49%), Positives = 171/298 (57%)

Query: 3   TGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGAN 62
           T SVTV+VP K+N+ LAVG    +G+H+L  VF AV L D+VTV  AD L +   G  A 
Sbjct: 2   TRSVTVRVPAKVNVQLAVGAPRPDGFHDLANVFLAVGLYDEVTVTPADTLRVTCEGPDAA 61

Query: 63  HVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            VP D  N+A RAA  +A   G APDV I I K IP                   ++LW 
Sbjct: 62  QVPLDTTNLAARAALALAARYGVAPDVHIHIAKDIPVAGGMAGGSADGAAALLACDTLWG 121

Query: 123 LSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTP 182
               R +L  + A+LGSDVPF+L GG ALG GRGE L  V    TFHWV A AD  L TP
Sbjct: 122 TGASREELLEICAELGSDVPFSLVGGAALGVGRGERLTAVEVGGTFHWVFAVADGGLSTP 181

Query: 183 AVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALR 242
           AVY EFDRL    + P  A    +L AL   D   LA  LGN+LQAAA+SL P+L   L 
Sbjct: 182 AVYGEFDRLTAGTDVPEPAASPALLTALRKGDVTALADALGNDLQAAALSLRPSLAGTLA 241

Query: 243 AGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           AG  AGALA +VSGSGPT AFL A   SA  V   L  +G CR+ RVA  P PGA VV
Sbjct: 242 AGTAAGALAALVSGSGPTTAFLTADEESARKVADALLASGTCRSARVAPSPAPGATVV 299


>tr|B5GPT9|B5GPT9_STRCL Tax_Id=443255 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Streptomyces clavuligerus ATCC 27064]
          Length = 317

 Score =  246 bits (627), Expect = 3e-63
 Identities = 140/296 (47%), Positives = 170/296 (57%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           +VTV+VP K+N+ L VG    +GYH+L  VF AVSL D+VT R AD L++   G GA  V
Sbjct: 22  TVTVRVPAKVNIQLGVGGARPDGYHDLANVFLAVSLYDRVTARPADTLTITCEGPGAAQV 81

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D  N+A RAA+L+AE  G APDV + I K IP                   ++LW L 
Sbjct: 82  PLDGTNLAARAAKLLAERHGIAPDVHLHIAKEIPVAGGMAGGSADGAAALLACDTLWGLG 141

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
             R +L  L A+LGSDVPF+L GG ALG GRGE L  +     FHWV A AD  L TPAV
Sbjct: 142 SSRAELLELCARLGSDVPFSLVGGAALGVGRGERLTPLEVGGEFHWVFAVADGGLSTPAV 201

Query: 185 YTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAG 244
           Y EFDRL +    P      P+LAAL   D   L   L N+LQ AA+SL P+L   L  G
Sbjct: 202 YGEFDRLNEGVRVPAPKASEPLLAALRTGDAPALGAALSNDLQPAALSLRPSLATTLTTG 261

Query: 245 MEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
             AGALA +VSGSGPT AFL + A SA+ +   L  +G C     AT P  GA V+
Sbjct: 262 RAAGALAALVSGSGPTTAFLASDAVSAVAIARALLASGTCVATHTATSPAAGATVL 317


>tr|A3TPV6|A3TPV6_9MICO Tax_Id=313589 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Janibacter sp. HTCC2649]
          Length = 312

 Score =  245 bits (625), Expect = 5e-63
 Identities = 147/300 (49%), Positives = 176/300 (58%), Gaps = 4/300 (1%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           VTV+VP K+NL L VG   D+G+H L TV+ AV+L D VTV   D  S  + G  A+ VP
Sbjct: 11  VTVRVPAKVNLELLVGPLRDDGFHTLSTVYQAVNLHDDVTVALDDEWSCSVSGPYADIVP 70

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
           TD  N+A RAA L+AE  G    V I I KSIP                   + LW L L
Sbjct: 71  TDASNLALRAARLLAEETGVETPVHISIAKSIPVAGGMAGGSADAAATLVACDRLWSLGL 130

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
              +L   AA+LGSDVPF + GGTA+G+GRGE LA VL+R ++HWV A +D  L TP VY
Sbjct: 131 STEELEEYAAELGSDVPFLIRGGTAVGSGRGERLAPVLARGSYHWVFAISDIGLSTPDVY 190

Query: 186 TEFDRLRDVGNPPRLAEPGP---VLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALR 242
            E DRLR    P   A P P   ++ AL + DP  LAP L N+LQ AA+SL P L   L 
Sbjct: 191 AECDRLRGKSKPAD-ASPEPNSQLMIALRSGDPHILAPQLTNDLQDAAISLRPELGELLA 249

Query: 243 AGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHA 302
           +GME GAL G+VSGSGPT AFL     SAID+   L   G  R VR A GPV GA V+ A
Sbjct: 250 SGMEFGALGGVVSGSGPTVAFLVEDVESAIDLTVALTATGAAREVRKAIGPVHGAHVIPA 309


>tr|B5HBH1|B5HBH1_STRPR Tax_Id=457429 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Streptomyces pristinaespiralis ATCC 25486]
          Length = 299

 Score =  242 bits (617), Expect = 5e-62
 Identities = 145/297 (48%), Positives = 175/297 (58%), Gaps = 2/297 (0%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           SVTV+VP K+N+ LAVG    +G+H+L  VF AV L D+VTVR A  L+L   G  A  V
Sbjct: 2   SVTVRVPAKVNVQLAVGGARPDGFHDLANVFLAVGLHDEVTVRPAPSLTLTCSGPDAGQV 61

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D  N+A RAAEL+A   G +PDV I IDK IP                   ++LW L 
Sbjct: 62  PLDRTNLAARAAELLAARHGISPDVHIHIDKDIPVAGGMAGGSADGAGALLACDALWGLG 121

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
             R +L  + A+LGSDVPF+L GG ALGTGRGE L  +    +F WV A AD  L TPAV
Sbjct: 122 SSREELLSICAELGSDVPFSLVGGAALGTGRGERLTELEVGGSFSWVFAVADGGLSTPAV 181

Query: 185 YTEFDRLRD-VGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRA 243
           Y EFDRL + V  P  +A P P+L AL   D   LA  + N+LQ AA+SL P+L   L  
Sbjct: 182 YGEFDRLNEGVSVPDPVASP-PLLDALRTGDVLALADAVSNDLQPAALSLRPSLADTLAV 240

Query: 244 GMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           G  AGALA +VSGSGPT AFL     +A  V + L  +G CR  RVA  P  GARVV
Sbjct: 241 GTAAGALAALVSGSGPTTAFLVKDEDAAETVASALRASGTCRAARVAGAPAVGARVV 297


>tr|C9YXY5|C9YXY5_STRSW Tax_Id=680198 SubName: Full=Putative
           isopentenyl monophosphate kinase;[Streptomyces scabies]
          Length = 304

 Score =  239 bits (610), Expect = 3e-61
 Identities = 142/298 (47%), Positives = 171/298 (57%), Gaps = 2/298 (0%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           SVTV+VP K+N+ LAVG    +G+H+L  VF AV L D+VT   AD L++   G GA+ V
Sbjct: 2   SVTVRVPAKVNVQLAVGGARPDGFHDLANVFLAVGLYDEVTATPADELTVTCAGPGADQV 61

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D  N+A RAA  +AE  G  P V + I K IP                   ++LW  +
Sbjct: 62  PLDRTNLAARAALALAERHGVEPAVHLHIAKDIPVAGGMAGGSADAAGALLACDTLWGTN 121

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
             R +L  + A+LGSDVPF+L GG ALGTGRGE+L  +    TFHWV A AD  L TPAV
Sbjct: 122 ASRDELLDMCAELGSDVPFSLVGGAALGTGRGEQLRPLDVGGTFHWVFAVADGGLSTPAV 181

Query: 185 YTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLL--GNELQAAAVSLDPALRCALR 242
           Y EFDRL      P       +L AL   D + LA  L   N LQ AA+SL P L   L 
Sbjct: 182 YREFDRLHADDTVPEPVASQVLLDALAKGDADALAAFLPDSNGLQPAALSLFPKLADTLT 241

Query: 243 AGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           AG  AGALA +VSGSGPT AFL   A +A  V A+L  +G CRT RVA  P PGA VV
Sbjct: 242 AGRAAGALAALVSGSGPTTAFLARDADAAHSVAAELLASGTCRTARVAVSPAPGATVV 299


>tr|B1VUG0|B1VUG0_STRGG Tax_Id=455632 SubName: Full=Putative
           4-(Cytidine-5-diphospho)-2-C-methyl-D-erythritol
           kinase;[Streptomyces griseus subsp. griseus]
          Length = 302

 Score =  239 bits (609), Expect = 4e-61
 Identities = 140/295 (47%), Positives = 168/295 (56%)

Query: 6   VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVP 65
           VTV+VP K+N+ LAVG    +G+H+L  VF AV L D+VT   AD L +   G  A  VP
Sbjct: 8   VTVRVPAKVNVQLAVGAARPDGFHDLANVFLAVGLYDEVTAAPADELRVTCSGPDAGQVP 67

Query: 66  TDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELSL 125
            D  N+A RAA  +AE  G  P V + I K IP                   ++LW    
Sbjct: 68  LDRTNLAARAALALAERYGIDPAVHLHIAKDIPVAGGMAGGSADGAAALVACDALWGTGA 127

Query: 126 PRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVY 185
            R +L  + A+LGSDVPF+L GG ALGTGRGE+L  +    TFHWV A AD  L TPAVY
Sbjct: 128 SRDELLAICAELGSDVPFSLVGGAALGTGRGEKLTPIEVGGTFHWVFAVADGGLSTPAVY 187

Query: 186 TEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 245
            EFDRL      P       +LAAL + DP  LA  L N+LQ AA+SL P+L   L AG 
Sbjct: 188 GEFDRLTAGTEVPEPTASPALLAALRSGDPGALAGALSNDLQPAALSLRPSLAETLAAGT 247

Query: 246 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
           EAGA A +VSGSGPT AFL   A +A  V A L  +G CR  RVA  P PGA V+
Sbjct: 248 EAGAPAALVSGSGPTTAFLVPDAETAEKVAAALLTSGTCRNARVAASPAPGAHVI 302


>tr|B5HKR8|B5HKR8_9ACTO Tax_Id=463191 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Streptomyces sviceus ATCC 29083]
          Length = 299

 Score =  239 bits (609), Expect = 4e-61
 Identities = 140/298 (46%), Positives = 172/298 (57%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           SVTV+VP K+N+ LAVG    +G+H+L  VF AV L D+VTV  AD L +   G  A  V
Sbjct: 2   SVTVRVPAKVNVQLAVGAARPDGFHDLANVFLAVGLHDEVTVTPADGLRVTCAGPDAGQV 61

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D  N+A RAA  +AE  G  PDV + I K IP                   ++LW   
Sbjct: 62  PLDRTNLAARAAIALAERHGLEPDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTG 121

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
             R +L  + A+LGSDVPF+L GG ALGTGRGE+L  +    TF WV A A+  L TPAV
Sbjct: 122 ASRAELLDICAELGSDVPFSLVGGAALGTGRGEKLRPLDVGGTFSWVFAMAERGLSTPAV 181

Query: 185 YTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAG 244
           + EFDRL    + P       +L AL   DP+ LA  + N+LQ AA+SL P L   L AG
Sbjct: 182 FREFDRLTAGLDVPEPVASEALLDALAEGDPDALAAAVSNDLQPAALSLFPELADTLAAG 241

Query: 245 MEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHA 302
             AGALAG+VSGSGPT AFL     SA  +   L  +G CR VR A+GPVPGA V+ A
Sbjct: 242 SAAGALAGLVSGSGPTTAFLARDPGSAAKIADALRASGTCRAVRTASGPVPGATVMGA 299


>sp|Q47SX2|ISPE_THEFY Tax_Id=269800 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Thermobifida fusca]
          Length = 307

 Score =  236 bits (603), Expect = 2e-60
 Identities = 144/304 (47%), Positives = 177/304 (58%), Gaps = 10/304 (3%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLS-----LGLVGE 59
           SVTV+VP K+NL LAVG    +GYH LV VFHAVSL D+VTV     L+     L + GE
Sbjct: 6   SVTVRVPAKVNLRLAVGPVRGDGYHGLVNVFHAVSLYDEVTVSPRSDLAPGQAVLSVDGE 65

Query: 60  GANHV---PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXX 116
             +HV   P D+ N+A RAA L+A HV  A  V I + K+IP                  
Sbjct: 66  RPDHVARVPLDDSNLAARAAALLARHVPHATGVHIHVHKAIPVAGGMAGGSADAAAALVA 125

Query: 117 MNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFAD 176
            ++LWE   PR  L  LAA+LGSDV F L G TA+GTGRGE+L+ +  + TFHWV A  D
Sbjct: 126 CDALWEGGTPRERLLELAAELGSDVAFPLIGCTAVGTGRGEQLSPLPVQGTFHWVFALVD 185

Query: 177 SSLLTPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPA 236
             L T  V+ E+DRLR     P L +   ++AAL A D  +L   L N+LQ AA++L P 
Sbjct: 186 GGLSTTKVFAEYDRLRPDAPEPTLDDA--LVAALAAGDARRLGAALTNDLQPAALALRPE 243

Query: 237 LRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPG 296
           L   L AG  AGAL  +VSGSGPTCAFL  SA  A ++ A L  +G C     A GPVPG
Sbjct: 244 LGDLLEAGRAAGALGALVSGSGPTCAFLAESADHARELAAALRASGTCADTVTAHGPVPG 303

Query: 297 ARVV 300
           A VV
Sbjct: 304 ATVV 307


>sp|Q820G3|ISPE_STRAW Tax_Id=33903 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Streptomyces avermitilis]
          Length = 297

 Score =  236 bits (601), Expect = 3e-60
 Identities = 139/296 (46%), Positives = 167/296 (56%)

Query: 5   SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHV 64
           SVTV+VP K+N+ LAVG    +G+H+L  VF AV L D+VT   AD L +   G  A  V
Sbjct: 2   SVTVRVPAKVNVQLAVGGARPDGFHDLANVFLAVGLYDEVTATPADELRITCEGPDAAQV 61

Query: 65  PTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELS 124
           P D  N+A RAA  +A   G APDV + I K IP                   ++LW  +
Sbjct: 62  PLDRTNLAARAAIALAARHGLAPDVHLHIAKDIPVAGGMAGGSADAAGALLACDTLWGTN 121

Query: 125 LPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAV 184
             R +L  + A+LGSDVPF+L GG ALGTGRGE L  +    TFHWV A AD  L TPAV
Sbjct: 122 ASRGELLDICAELGSDVPFSLVGGAALGTGRGERLRELEVGGTFHWVFAVADGGLSTPAV 181

Query: 185 YTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAG 244
           Y EFDRL +    P       +L AL   D   LA  + N+LQ AA+SL P+L   L AG
Sbjct: 182 YGEFDRLSEGVRVPEPVASQELLDALAKGDAVALAAAVSNDLQPAALSLFPSLSDTLEAG 241

Query: 245 MEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300
             AGALA +VSGSGPT AFL   A  A  V   L  +G CRT RVA  P PGA V+
Sbjct: 242 RAAGALAALVSGSGPTTAFLTRDADGADAVAQALLASGTCRTARVAPSPAPGATVL 297


  Database: Amellifera_nr
    Posted date:  Jan 15, 2010  5:10 AM
  Number of letters in database: 3,808,957,724
  Number of sequences in database:  11,153,314
  
Lambda     K      H
   0.320    0.135    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 11153314
Number of Hits to DB: 2,203,533,848
Number of extensions: 87954668
Number of successful extensions: 247635
Number of sequences better than 10.0: 1919
Number of HSP's gapped: 247542
Number of HSP's successfully gapped: 1931
Length of query: 311
Length of database: 3,808,957,724
Length adjustment: 137
Effective length of query: 174
Effective length of database: 2,280,953,706
Effective search space: 396885944844
Effective search space used: 396885944844
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 80 (35.4 bits)