BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= ML0732
         (274 letters)

Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr;
Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr;
trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr;
Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr;
Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr;
Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr;
Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr;
Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr;
Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr;
Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr;
Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr;
Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 
           11,153,314 sequences; 3,808,957,724 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits)  Value

tr|Q9CCL3|Q9CCL3_MYCLE Tax_Id=1769 (birA)SubName: Full=Biotin ap...   484   e-135
tr|B8ZUY1|B8ZUY1_MYCLB Tax_Id=561304 (birA)SubName: Full=Biotin ...   484   e-135
tr|A0QKF1|A0QKF1_MYCA1 Tax_Id=243243 SubName: Full=Biotin-[acety...   348   3e-94
tr|Q73UH1|Q73UH1_MYCPA Tax_Id=1770 (birA)SubName: Full=BirA;[Myc...   348   4e-94
tr|B2HEK8|B2HEK8_MYCMM Tax_Id=216594 (birA)SubName: Full=Bifunct...   337   1e-90
tr|A0PRJ0|A0PRJ0_MYCUA Tax_Id=362242 (birA)SubName: Full=Bifunct...   332   4e-89
tr|P96884|P96884_MYCTU Tax_Id=1773 (birA)SubName: Full=BirA bifu...   331   6e-89
tr|C6DL16|C6DL16_MYCTK Tax_Id=478434 SubName: Full=Biotin-protei...   331   6e-89
tr|A5U7V3|A5U7V3_MYCTA Tax_Id=419947 (birA)SubName: Full=Putativ...   331   6e-89
tr|A5WSJ4|A5WSJ4_MYCTF Tax_Id=336982 SubName: Full=Bifunctional ...   331   6e-89
tr|A2VP75|A2VP75_MYCTU Tax_Id=348776 SubName: Full=Bifunctional ...   331   6e-89
tr|A4KLH5|A4KLH5_MYCTU Tax_Id=395095 SubName: Full=Bifunctional ...   330   8e-89
tr|Q7TWU0|Q7TWU0_MYCBO Tax_Id=1765 (birA)SubName: Full=POSSIBLE ...   329   2e-88
tr|C1AH53|C1AH53_MYCBT Tax_Id=561275 (birA)SubName: Full=Putativ...   329   2e-88
tr|A1KNT1|A1KNT1_MYCBP Tax_Id=410289 (birA)SubName: Full=Possibl...   329   2e-88
tr|A1T5U5|A1T5U5_MYCVP Tax_Id=350058 SubName: Full=Biotin--acety...   240   1e-61
tr|A4TF64|A4TF64_MYCGI Tax_Id=350054 SubName: Full=Biotin--acety...   231   5e-59
tr|B1MF94|B1MF94_MYCA9 Tax_Id=561007 SubName: Full=Possible biot...   225   5e-57
tr|Q1BCG8|Q1BCG8_MYCSS Tax_Id=164756 SubName: Full=Biotin--acety...   214   1e-53
tr|A1UCH5|A1UCH5_MYCSK Tax_Id=189918 SubName: Full=Biotin--acety...   214   1e-53
tr|A3PW65|A3PW65_MYCSJ Tax_Id=164757 SubName: Full=Biotin--acety...   213   2e-53
tr|A0QTF5|A0QTF5_MYCS2 Tax_Id=246196 SubName: Full=Biotin-[acety...   206   3e-51
tr|B1W2T0|B1W2T0_STRGG Tax_Id=455632 SubName: Full=Putative biot...   177   1e-42
tr|B5HUZ7|B5HUZ7_9ACTO Tax_Id=463191 SubName: Full=Biotin apo-pr...   176   2e-42
tr|C3JG94|C3JG94_RHOER Tax_Id=596309 SubName: Full=Biotin-[acety...   176   3e-42
tr|C0ZWV5|C0ZWV5_RHOE4 Tax_Id=234621 (birA)SubName: Full=Biotin ...   175   6e-42
tr|C9N8G9|C9N8G9_9ACTO Tax_Id=591167 SubName: Full=Biotin/acetyl...   172   3e-41
tr|Q9EWV9|Q9EWV9_STRCO Tax_Id=1902 SubName: Full=Putative ligase...   172   4e-41
tr|B9VRF4|B9VRF4_9ACTO Tax_Id=67369 SubName: Full=Bpl;[Streptomy...   171   1e-40
tr|Q82I28|Q82I28_STRAW Tax_Id=33903 (birA)SubName: Full=Putative...   169   4e-40
tr|Q0S316|Q0S316_RHOSR Tax_Id=101510 SubName: Full=Biotin--[acet...   169   4e-40
tr|C1B1A9|C1B1A9_RHOOB Tax_Id=632772 (birA)SubName: Full=Biotin ...   165   4e-39
tr|B4VAK3|B4VAK3_9ACTO Tax_Id=465541 SubName: Full=Biotin apo-pr...   165   4e-39
tr|A6WEY2|A6WEY2_KINRD Tax_Id=266940 SubName: Full=Biotin--acety...   164   1e-38
tr|C2ARG0|C2ARG0_TSUPA Tax_Id=521096 SubName: Full=BirA, biotin-...   162   3e-38
tr|B5GSW5|B5GSW5_STRCL Tax_Id=443255 SubName: Full=Biotin apo-pr...   162   4e-38
tr|Q5Z151|Q5Z151_NOCFA Tax_Id=37329 (birA)SubName: Full=Putative...   160   2e-37
tr|B5H4Z5|B5H4Z5_STRPR Tax_Id=457429 SubName: Full=Biotin apo-pr...   158   5e-37
tr|C9ZGV6|C9ZGV6_STRSW Tax_Id=680198 SubName: Full=Putative unch...   157   9e-37
tr|C1WK69|C1WK69_9ACTO Tax_Id=479435 SubName: Full=BirA, biotin-...   152   3e-35
tr|Q47LT6|Q47LT6_THEFY Tax_Id=269800 SubName: Full=Biotin--acety...   148   7e-34
tr|C4ECY6|C4ECY6_STRRS Tax_Id=479432 SubName: Full=BirA, biotin-...   144   8e-33
tr|A8M2V4|A8M2V4_SALAI Tax_Id=391037 SubName: Full=Biotin--acety...   144   1e-32
tr|C7Q0X6|C7Q0X6_CATAD Tax_Id=479433 SubName: Full=Biotin/acetyl...   143   2e-32
tr|C4RPP4|C4RPP4_9ACTO Tax_Id=219305 SubName: Full=Biotin-acetyl...   143   2e-32
tr|C7MUU8|C7MUU8_SACVD Tax_Id=471857 SubName: Full=BirA, biotin-...   137   1e-30
tr|D0L8T0|D0L8T0_9ACTO Tax_Id=526226 SubName: Full=Biotin/acetyl...   137   1e-30
tr|C1YKR2|C1YKR2_NOCDA Tax_Id=446468 SubName: Full=BirA, biotin-...   137   1e-30
tr|C2A4R6|C2A4R6_THECU Tax_Id=471852 SubName: Full=BirA, biotin-...   137   1e-30
tr|A4X384|A4X384_SALTO Tax_Id=369723 SubName: Full=Biotin--acety...   136   3e-30

>tr|Q9CCL3|Q9CCL3_MYCLE Tax_Id=1769 (birA)SubName: Full=Biotin
           apo-protein ligase;[Mycobacterium leprae]
          Length = 274

 Score =  484 bits (1247), Expect = e-135
 Identities = 245/259 (94%), Positives = 245/259 (94%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA
Sbjct: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP
Sbjct: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
           PGSKGKLAGILAE              TQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL
Sbjct: 136 PGSKGKLAGILAEVVRPVIVVGVGLNVTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE
Sbjct: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255

Query: 256 GPTKGQTVVISAGDVVHLR 274
           GPTKGQTVVISAGDVVHLR
Sbjct: 256 GPTKGQTVVISAGDVVHLR 274


>tr|B8ZUY1|B8ZUY1_MYCLB Tax_Id=561304 (birA)SubName: Full=Biotin
           apo-protein ligase;[Mycobacterium leprae]
          Length = 274

 Score =  484 bits (1247), Expect = e-135
 Identities = 245/259 (94%), Positives = 245/259 (94%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA
Sbjct: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP
Sbjct: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
           PGSKGKLAGILAE              TQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL
Sbjct: 136 PGSKGKLAGILAEVVRPVIVVGVGLNVTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE
Sbjct: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255

Query: 256 GPTKGQTVVISAGDVVHLR 274
           GPTKGQTVVISAGDVVHLR
Sbjct: 256 GPTKGQTVVISAGDVVHLR 274


>tr|A0QKF1|A0QKF1_MYCA1 Tax_Id=243243 SubName:
           Full=Biotin-[acetyl-CoA-carboxylase] ligase;
           EC=6.3.4.15;[Mycobacterium avium]
          Length = 264

 Score =  348 bits (894), Expect = 3e-94
 Identities = 183/262 (69%), Positives = 201/262 (76%), Gaps = 7/262 (2%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           RAELIGTGL WR+LDVV QTGSTNADLLARAA+G D+ GAVLIAEHQTAGRGRHGRGWSA
Sbjct: 7   RAELIGTGLGWRRLDVVEQTGSTNADLLARAAAGDDVAGAVLIAEHQTAGRGRHGRGWSA 66

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           +PR Q+TMS+GVS+ DVP A W WL LATGVAV+DTVAPL+   GV  GLKWPNDVLAGP
Sbjct: 67  TPRAQVTMSVGVSVVDVPAAGWGWLPLATGVAVVDTVAPLLQPAGVAVGLKWPNDVLAGP 126

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
            GS GKLAGILAE              TQ+  E+DGPGATSLLDLGV APDR  LV  LL
Sbjct: 127 AGSPGKLAGILAEVSKPVVVIGLGLNVTQSADEIDGPGATSLLDLGVAAPDRTALVSGLL 186

Query: 196 RELDARVGQW---RSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCL 252
           REL  R+  W   R AD  L ADYRARS  IG+RVRA+LPGGK + GT  GIDDQGRLCL
Sbjct: 187 RELGRRIVSWQAARGADWALAADYRARSLTIGTRVRADLPGGKHIEGTAGGIDDQGRLCL 246

Query: 253 KTEGPTKGQTVVISAGDVVHLR 274
                + GQTVV++AGDVVHLR
Sbjct: 247 ----DSGGQTVVVAAGDVVHLR 264


>tr|Q73UH1|Q73UH1_MYCPA Tax_Id=1770 (birA)SubName:
           Full=BirA;[Mycobacterium paratuberculosis]
          Length = 281

 Score =  348 bits (893), Expect = 4e-94
 Identities = 183/262 (69%), Positives = 201/262 (76%), Gaps = 7/262 (2%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           RAELIGTGL WR+LDVV QTGSTNADLLARAA+G D+ GAVLIAEHQTAGRGRHGRGWSA
Sbjct: 24  RAELIGTGLGWRRLDVVEQTGSTNADLLARAAAGDDVAGAVLIAEHQTAGRGRHGRGWSA 83

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           +PR Q+TMS+GVS+ DVP A W WL LATGVAV+DTVAPL+   GV  GLKWPNDVLAGP
Sbjct: 84  TPRAQVTMSVGVSVVDVPAAGWGWLPLATGVAVVDTVAPLLQPAGVAVGLKWPNDVLAGP 143

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
            G+ GKLAGILAE              TQ+  E+DGPGATSLLDLGV APDR  LV  LL
Sbjct: 144 AGTPGKLAGILAEVSKPVVVIGLGLNVTQSADEIDGPGATSLLDLGVAAPDRTALVSGLL 203

Query: 196 RELDARVGQW---RSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCL 252
           REL  R+  W   R AD  L ADYRARS  IG+RVRA+LPGGK V GT  GIDDQGRLCL
Sbjct: 204 RELGRRIVSWQAARGADWALAADYRARSLTIGTRVRADLPGGKHVEGTASGIDDQGRLCL 263

Query: 253 KTEGPTKGQTVVISAGDVVHLR 274
                + GQTVV++AGDVVHLR
Sbjct: 264 ----DSGGQTVVVAAGDVVHLR 281


>tr|B2HEK8|B2HEK8_MYCMM Tax_Id=216594 (birA)SubName:
           Full=Bifunctional protein BirA;[Mycobacterium marinum]
          Length = 276

 Score =  337 bits (863), Expect = 1e-90
 Identities = 176/262 (67%), Positives = 202/262 (77%), Gaps = 5/262 (1%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R+E I +G  WRQLDVV +TGSTNADLLARAA+G DI+GAVLIAEHQTAGRGR GRGWSA
Sbjct: 17  RSEAIDSG--WRQLDVVDETGSTNADLLARAAAGADIEGAVLIAEHQTAGRGRLGRGWSA 74

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QITMS+GV +  VP ATW WLSLATG+AV+DTV PL+D T   AGLKWPNDVLAGP
Sbjct: 75  TARAQITMSVGVRVDGVPTATWGWLSLATGLAVVDTVTPLLDGTAAQAGLKWPNDVLAGP 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
           PGS GKLAGILAE              TQAP E+ GP ATSLLDLGVPAPDR +L   LL
Sbjct: 135 PGSLGKLAGILAEVAMPYAVIGIGLNVTQAPDEIAGPAATSLLDLGVPAPDRNELAARLL 194

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKT- 254
           REL AR+ ++R A  +L ADYRARS  IGSRVRA+LPGG+++VG  R ID+QGRL L+T 
Sbjct: 195 RELAARIDEFRRAHARLSADYRARSLTIGSRVRAQLPGGREIVGIARDIDEQGRLRLQTT 254

Query: 255 --EGPTKGQTVVISAGDVVHLR 274
             E    G+TVV++AGDVVHLR
Sbjct: 255 PDEAGKSGETVVVAAGDVVHLR 276


>tr|A0PRJ0|A0PRJ0_MYCUA Tax_Id=362242 (birA)SubName:
           Full=Bifunctional protein BirA;[Mycobacterium ulcerans]
          Length = 276

 Score =  332 bits (850), Expect = 4e-89
 Identities = 174/262 (66%), Positives = 201/262 (76%), Gaps = 5/262 (1%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R+E I +G  WRQLDVV +TGSTNADLLARAA+G DI+GAVLIAEHQTAGRGR GRGWSA
Sbjct: 17  RSEAIDSG--WRQLDVVDETGSTNADLLARAAAGADIEGAVLIAEHQTAGRGRLGRGWSA 74

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QITMS+GV +  VP ATW WLSLATG+AV+DTV PL+D T   AGLKWPNDVLAG 
Sbjct: 75  TARAQITMSVGVRVDGVPTATWGWLSLATGLAVVDTVTPLLDGTAAQAGLKWPNDVLAGL 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
           PGS GKLAGILAE              TQAP E+ GP ATSLLDLGVPAPDR ++   LL
Sbjct: 135 PGSLGKLAGILAEVAMPYAVIGIGLNVTQAPDEIAGPAATSLLDLGVPAPDRNEVAARLL 194

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKT- 254
           REL AR+ ++R A  +L ADYRARS  IGSRVRA+LPGG+++VG  R ID+QGRL L+T 
Sbjct: 195 RELAARIDEFRRAHARLSADYRARSLTIGSRVRAQLPGGREIVGIARDIDEQGRLRLQTT 254

Query: 255 --EGPTKGQTVVISAGDVVHLR 274
             E    G+TVV++AGDVVHLR
Sbjct: 255 PDEAGKSGETVVVAAGDVVHLR 276


>tr|P96884|P96884_MYCTU Tax_Id=1773 (birA)SubName: Full=BirA
           bifunctional protein; EC=6.3.4.15; SubName:
           Full=POSSIBLE BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON
           REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE
           (BIOTIN--PROTEIN LIGASE); EC=6.3.4.15;[Mycobacterium
           tuberculosis]
          Length = 266

 Score =  331 bits (848), Expect = 6e-89
 Identities = 177/259 (68%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL ADYRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|C6DL16|C6DL16_MYCTK Tax_Id=478434 SubName: Full=Biotin-protein
           ligase;[Mycobacterium tuberculosis]
          Length = 266

 Score =  331 bits (848), Expect = 6e-89
 Identities = 177/259 (68%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL ADYRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|A5U7V3|A5U7V3_MYCTA Tax_Id=419947 (birA)SubName: Full=Putative
           bifunctional protein BirA;[Mycobacterium tuberculosis]
          Length = 266

 Score =  331 bits (848), Expect = 6e-89
 Identities = 177/259 (68%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL ADYRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|A5WSJ4|A5WSJ4_MYCTF Tax_Id=336982 SubName: Full=Bifunctional
           protein birA: biotin operon repressor +
           biotin-[acetyl-CoA-carboxylase]
           synthetase;[Mycobacterium tuberculosis]
          Length = 266

 Score =  331 bits (848), Expect = 6e-89
 Identities = 177/259 (68%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL ADYRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|A2VP75|A2VP75_MYCTU Tax_Id=348776 SubName: Full=Bifunctional
           protein birA : biotin operon repressor +
           biotin-[acetyl-CoA-carboxylase]
           synthetase;[Mycobacterium tuberculosis C]
          Length = 266

 Score =  331 bits (848), Expect = 6e-89
 Identities = 177/259 (68%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL ADYRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|A4KLH5|A4KLH5_MYCTU Tax_Id=395095 SubName: Full=Bifunctional
           protein birA : biotin operon repressor +
           biotin-[acetyl-CoA-carboxylase]
           synthetase;[Mycobacterium tuberculosis str. Haarlem]
          Length = 266

 Score =  330 bits (847), Expect = 8e-89
 Identities = 177/259 (68%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL ADYRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAADYRARSLTIGSRVRIELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|Q7TWU0|Q7TWU0_MYCBO Tax_Id=1765 (birA)SubName: Full=POSSIBLE
           BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON REPRESSOR +
           BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE
           (BIOTIN--PROTEIN LIGASE); EC=6.3.4.15;[Mycobacterium
           bovis]
          Length = 266

 Score =  329 bits (843), Expect = 2e-88
 Identities = 176/259 (67%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL A+YRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAANYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|C1AH53|C1AH53_MYCBT Tax_Id=561275 (birA)SubName: Full=Putative
           biotin operon repressor; EC=6.3.4.15;[Mycobacterium
           bovis]
          Length = 266

 Score =  329 bits (843), Expect = 2e-88
 Identities = 176/259 (67%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL A+YRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAANYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|A1KNT1|A1KNT1_MYCBP Tax_Id=410289 (birA)SubName: Full=Possible
           bifunctional protein birA: biotin operon repressor +
           biotin--[acetyl-coa-carboxylase] synthetase;
           EC=6.3.4.15;[Mycobacterium bovis]
          Length = 266

 Score =  329 bits (843), Expect = 2e-88
 Identities = 176/259 (67%), Positives = 196/259 (75%), Gaps = 9/259 (3%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R +LIG G  WRQLDVV QTGSTNADLLARAASG DIDG VLIAEHQTAGRGRHGRGW+A
Sbjct: 17  RDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAA 76

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
           + R QI +S+GV + DVPV  W WLSLA G+AVLD+VAPLI V   + GLKWPNDVLA  
Sbjct: 77  TARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLA-- 134

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
               GKLAGILAE              TQAP+EVD P ATSLLDLGV APDR ++   LL
Sbjct: 135 --RGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLL 191

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           REL+AR+ QWR+A+PQL A+YRARS  IGSRVR ELPGG+DVVG  R IDDQGRLCL   
Sbjct: 192 RELEARIIQWRNANPQLAANYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCL--- 248

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G+TVV+SAGDVVHLR
Sbjct: 249 -DVGGRTVVVSAGDVVHLR 266


>tr|A1T5U5|A1T5U5_MYCVP Tax_Id=350058 SubName:
           Full=Biotin--acetyl-CoA-carboxylase
           ligase;[Mycobacterium vanbaalenii]
          Length = 257

 Score =  240 bits (613), Expect = 1e-61
 Identities = 131/249 (52%), Positives = 161/249 (64%), Gaps = 12/249 (4%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           WR++DVV +TGSTNADL+ARAA+G DI GAVL+AEHQTAGRGRHGR WSA PR+QI+MS+
Sbjct: 19  WRRVDVVEETGSTNADLIARAAAGEDIAGAVLLAEHQTAGRGRHGRSWSAPPRSQISMSV 78

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
           GV    VP   W WL L TG+AV   V    +  GVDAG+KWPND+L G     GKLAGI
Sbjct: 79  GVDATGVPAERWGWLPLLTGLAVAHVVR---EDYGVDAGVKWPNDILVG----TGKLAGI 131

Query: 146 LAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQW 205
           LAE              +    E+  P A SL+ LG  A DR  L   +L+EL  ++ +W
Sbjct: 132 LAEVSAPVIVVGLGLNVSFTADELPDPNAVSLMMLGHDA-DRTALAATVLQELSRQLHRW 190

Query: 206 RSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQTVVI 265
           R+ DP L ADYR  S  +G+ VRA LPGG ++VG   GIDD GRL +  +    G TV +
Sbjct: 191 RAGDPGLAADYRNASTTLGAPVRAVLPGGSEIVGVATGIDDAGRLLIDDD----GTTVTV 246

Query: 266 SAGDVVHLR 274
           SAGD+ HLR
Sbjct: 247 SAGDITHLR 255


>tr|A4TF64|A4TF64_MYCGI Tax_Id=350054 SubName:
           Full=Biotin--acetyl-CoA-carboxylase
           ligase;[Mycobacterium gilvum]
          Length = 266

 Score =  231 bits (590), Expect = 5e-59
 Identities = 134/256 (52%), Positives = 158/256 (61%), Gaps = 15/256 (5%)

Query: 22  TGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQI 81
           TG  W ++DVV +TGSTNADL+ARA  G DI GAVL+AEHQTAGRGRHGR WSA PR+QI
Sbjct: 19  TGTEWHRVDVVDETGSTNADLIARADRGEDIAGAVLLAEHQTAGRGRHGRTWSAPPRSQI 78

Query: 82  TMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGK 141
           +MS GV    VP A W WL L TG+AV  T   L +  GV+AG+KWPNDV+ GP     K
Sbjct: 79  SMSFGVDTTGVPPAGWGWLPLLTGLAVAHT---LRESYGVNAGVKWPNDVMVGP----RK 131

Query: 142 LAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDAR 201
           LAGILAE                   E+  P A SL  L   A DR QL   LL+E  +R
Sbjct: 132 LAGILAEVSGPVIVVGLGLNVEMTVDELPDPNAMSLSMLNHHA-DRTQLTASLLQEFSSR 190

Query: 202 VGQWR---SADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPT 258
           + +WR    AD  L  DYR RS  IG+RVRA LPG  +++G   GIDD GRL + TE   
Sbjct: 191 LRRWRLAGGADAGLATDYRERSTTIGTRVRALLPGDSEIIGVATGIDDAGRLLIDTE--- 247

Query: 259 KGQTVVISAGDVVHLR 274
            G TV +SA D+ HLR
Sbjct: 248 -GTTVTVSAADITHLR 262


>tr|B1MF94|B1MF94_MYCA9 Tax_Id=561007 SubName: Full=Possible
           biotin--acetyl-CoA-carboxylase ligase (BirA bifunctional
           protein);[Mycobacterium abscessus]
          Length = 264

 Score =  225 bits (573), Expect = 5e-57
 Identities = 124/257 (48%), Positives = 162/257 (63%), Gaps = 15/257 (5%)

Query: 23  GLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQIT 82
           G  WR++DVV +TGSTNADL+ RAA+G DIDG VL+AEHQTAGRGRHGR W A   TQ++
Sbjct: 13  GGHWRRIDVVEETGSTNADLVTRAAAGEDIDGVVLLAEHQTAGRGRHGRSWGAPAHTQLS 72

Query: 83  MSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKL 142
           MS+G+ + +VP   W  + L  GVA++D VA   +V+G+ AGLKWPNDVL        KL
Sbjct: 73  MSVGIGVGEVPPDRWGLVPLLAGVAIVDAVA---EVSGIQAGLKWPNDVLV----DGRKL 125

Query: 143 AGILAE--XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDA 200
            GILAE                T A  E+  P ATSL  LG   PDR++L   +LREL  
Sbjct: 126 CGILAEVATPHQAIVLGLGLNATFAQHELPDPNATSLTILGWADPDRDELARAVLRELGG 185

Query: 201 RVGQWRSA---DPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGP 257
           R+  WR+A   D +L+ DYR RS  +GSRVRAELPG +++VG   G+ + G+L ++    
Sbjct: 186 RIEHWRAARGLDERLLEDYRERSVTLGSRVRAELPGERELVGVAVGLGNDGQLRIEA--- 242

Query: 258 TKGQTVVISAGDVVHLR 274
             G    ++AGD+ HLR
Sbjct: 243 ADGTVTAVTAGDITHLR 259


>tr|Q1BCG8|Q1BCG8_MYCSS Tax_Id=164756 SubName:
           Full=Biotin--acetyl-CoA-carboxylase
           ligase;[Mycobacterium sp.]
          Length = 270

 Score =  214 bits (544), Expect = 1e-53
 Identities = 127/257 (49%), Positives = 153/257 (59%), Gaps = 16/257 (6%)

Query: 23  GLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQIT 82
           G  WR LDVV +TGSTNADLLARAA+G D+ G+VL+ E Q+AGRGRHGR W+A PR+Q+ 
Sbjct: 19  GEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSAGRGRHGRQWTAPPRSQVA 78

Query: 83  MSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKL 142
           MS+ V    V    W WL L TGVAV D VA   +V+ V+AGLKWPNDVL G    +GKL
Sbjct: 79  MSVAVDAGGVRPDAWGWLPLLTGVAVRDAVA---EVSAVEAGLKWPNDVLVG----EGKL 131

Query: 143 AGILAE--XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDA 200
           AGILAE                T +  E   P ATSL  LG    DR  L   LLR L  
Sbjct: 132 AGILAEVAAPQHVVIVGIGLNVTLSAAEAPDPRATSLTMLGARNHDRTALAAALLRNLGT 191

Query: 201 RVGQWR---SADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGP 257
           R+ +WR    AD  L+ADYR  S  +G  V A LPG + + GT   IDD GRL +     
Sbjct: 192 RIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDDLGRLTI----T 247

Query: 258 TKGQTVVISAGDVVHLR 274
           T   +V ++AGD+ HLR
Sbjct: 248 TGRDSVTVAAGDITHLR 264


>tr|A1UCH5|A1UCH5_MYCSK Tax_Id=189918 SubName:
           Full=Biotin--acetyl-CoA-carboxylase
           ligase;[Mycobacterium sp.]
          Length = 270

 Score =  214 bits (544), Expect = 1e-53
 Identities = 127/257 (49%), Positives = 153/257 (59%), Gaps = 16/257 (6%)

Query: 23  GLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQIT 82
           G  WR LDVV +TGSTNADLLARAA+G D+ G+VL+ E Q+AGRGRHGR W+A PR+Q+ 
Sbjct: 19  GEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSAGRGRHGRQWTAPPRSQVA 78

Query: 83  MSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKL 142
           MS+ V    V    W WL L TGVAV D VA   +V+ V+AGLKWPNDVL G    +GKL
Sbjct: 79  MSVAVDAGGVRPDAWGWLPLLTGVAVRDAVA---EVSAVEAGLKWPNDVLVG----EGKL 131

Query: 143 AGILAE--XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDA 200
           AGILAE                T +  E   P ATSL  LG    DR  L   LLR L  
Sbjct: 132 AGILAEVAAPQHVVIVGIGLNVTLSAAEAPDPRATSLTMLGARNHDRTALAAALLRNLGT 191

Query: 201 RVGQWR---SADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGP 257
           R+ +WR    AD  L+ADYR  S  +G  V A LPG + + GT   IDD GRL +     
Sbjct: 192 RIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDDLGRLTI----T 247

Query: 258 TKGQTVVISAGDVVHLR 274
           T   +V ++AGD+ HLR
Sbjct: 248 TGRDSVTVAAGDITHLR 264


>tr|A3PW65|A3PW65_MYCSJ Tax_Id=164757 SubName:
           Full=Biotin--acetyl-CoA-carboxylase
           ligase;[Mycobacterium sp.]
          Length = 270

 Score =  213 bits (541), Expect = 2e-53
 Identities = 126/257 (49%), Positives = 153/257 (59%), Gaps = 16/257 (6%)

Query: 23  GLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQIT 82
           G  WR LDVV +TGSTNADLLARAA+G D+ G+VL+ E Q++GRGRHGR W+A PR+Q+ 
Sbjct: 19  GEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSSGRGRHGRQWTAPPRSQVA 78

Query: 83  MSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKL 142
           MS+ V    V    W WL L TGVAV D VA   +V+ V+AGLKWPNDVL G    +GKL
Sbjct: 79  MSVAVDAGGVRPDAWGWLPLLTGVAVRDAVA---EVSAVEAGLKWPNDVLVG----EGKL 131

Query: 143 AGILAE--XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDA 200
           AGILAE                T +  E   P ATSL  LG    DR  L   LLR L  
Sbjct: 132 AGILAEVAAPQHVVIVGIGLNVTLSAAEAPDPRATSLTMLGARNHDRTALAAALLRNLGT 191

Query: 201 RVGQWR---SADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGP 257
           R+ +WR    AD  L+ADYR  S  +G  V A LPG + + GT   IDD GRL +     
Sbjct: 192 RIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDDLGRLTI----T 247

Query: 258 TKGQTVVISAGDVVHLR 274
           T   +V ++AGD+ HLR
Sbjct: 248 TGRDSVTVAAGDITHLR 264


>tr|A0QTF5|A0QTF5_MYCS2 Tax_Id=246196 SubName:
           Full=Biotin-[acetyl-CoA-carboxylase] ligase;
           EC=6.3.4.15;[Mycobacterium smegmatis]
          Length = 270

 Score =  206 bits (523), Expect = 3e-51
 Identities = 122/254 (48%), Positives = 152/254 (59%), Gaps = 16/254 (6%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           WR  DVV +TGSTNADLLARA SG DI+GAVL AEHQTAGRGR+GR W+  PR+QI +S+
Sbjct: 26  WRSFDVVAETGSTNADLLARARSGTDINGAVLAAEHQTAGRGRNGRQWTTPPRSQIAVSV 85

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
           G+    VP   W  L LATGVAV+D ++    VTGV+A LKWPNDVL       GKLAGI
Sbjct: 86  GIDTTGVPSTAWGLLPLATGVAVVDAISA---VTGVEAKLKWPNDVLV----DTGKLAGI 138

Query: 146 LAEXXXXXXXXXXXXXXTQA--PKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVG 203
           LAE                +  P +V    ATSL  L     DR  L+   L  L  RV 
Sbjct: 139 LAEVASPAPTVVIGTGLNVSVMPDDVPDSVATSLAMLTDAPVDRSALLTEFLTRLADRVE 198

Query: 204 QWRS---ADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKG 260
            WR+   AD +L+ DYR  S  +G+ VR  LPG + ++G    ID+ GRL + +E    G
Sbjct: 199 SWRAAGGADDRLLDDYRQCSGTLGTAVRVLLPGDRQLLGDAVDIDESGRLLIDSE----G 254

Query: 261 QTVVISAGDVVHLR 274
           + + ++AGDV HLR
Sbjct: 255 ERITVAAGDVTHLR 268


>tr|B1W2T0|B1W2T0_STRGG Tax_Id=455632 SubName: Full=Putative biotin
           apo-protein ligase;[Streptomyces griseus subsp. griseus]
          Length = 289

 Score =  177 bits (449), Expect = 1e-42
 Identities = 109/254 (42%), Positives = 132/254 (51%), Gaps = 11/254 (4%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W  L+VV  TGSTN DL  RA  G   +GAVLIAE QTAGRGR  R W+A PR+ + +S+
Sbjct: 35  WTSLEVVESTGSTNTDLAERARGGAAGEGAVLIAEEQTAGRGRLERTWTAPPRSGLFLSV 94

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
            +   D+PV  W W+ L  GVA       L    GVD  LKWPND+L    G + K  GI
Sbjct: 95  HLEPGDIPVERWGWVPLLVGVA---AATGLAKSAGVDMSLKWPNDLLVSVGGEERKTGGI 151

Query: 146 LAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQW 205
           L E              T    E+  P A SL   G  + DRE L+  +LR L+   G+W
Sbjct: 152 LGEFAGNGIVVGLGVNVTLRADELPAPTAGSLALAGAVSTDRETLLRAVLRSLEDWYGRW 211

Query: 206 RSADPQ-----LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKG 260
           R+AD       L A Y A    +   VRAELPGG  +VG    ID  GRL L  E    G
Sbjct: 212 RAADGDAAASGLQAAYAAGCATLDRTVRAELPGGTSLVGEAVAIDGDGRLVLSAE---DG 268

Query: 261 QTVVISAGDVVHLR 274
               +SAGD+VHLR
Sbjct: 269 LRRPVSAGDIVHLR 282


>tr|B5HUZ7|B5HUZ7_9ACTO Tax_Id=463191 SubName: Full=Biotin
           apo-protein ligase;[Streptomyces sviceus ATCC 29083]
          Length = 290

 Score =  176 bits (447), Expect = 2e-42
 Identities = 114/265 (43%), Positives = 145/265 (54%), Gaps = 12/265 (4%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L+  G  W  ++VV  TGSTN+DL+ARA +G   +GAVL+AE QTAGRGR  R WSA
Sbjct: 30  RRGLVREGGLWSGIEVVAGTGSTNSDLVARATAGKATEGAVLVAEEQTAGRGRLDRQWSA 89

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
             R+ +  S+ ++ ADVPVA W WL L TGVAV      L    GVD  LKWPND+L   
Sbjct: 90  PARSGLFFSVLLNPADVPVARWGWLPLLTGVAV---ATGLSRAAGVDTALKWPNDLLVTV 146

Query: 136 PGSKGKLAGILAE-XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWL 194
            G + K  GILAE               T    E+  P A SL   G  + DR+ L+  +
Sbjct: 147 GGEERKAGGILAERAGEDGVVVGVGINVTLREDELPVPTAGSLALAGAVSTDRDPLLRAV 206

Query: 195 LRELDARVGQWRSA--DPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGR 249
           LR L+    +WR+A  DP    L   Y A    +G  VRAELPG + +VG    +D  GR
Sbjct: 207 LRSLEEWYERWRAAAGDPTVSGLQETYAAGCATLGRTVRAELPGDRALVGEAVAVDGDGR 266

Query: 250 LCLKTEGPTKGQTVVISAGDVVHLR 274
           L + TE   +G    + AGD+VHLR
Sbjct: 267 LVIATE---EGVQKPVGAGDIVHLR 288


>tr|C3JG94|C3JG94_RHOER Tax_Id=596309 SubName:
           Full=Biotin-[acetyl-CoA-carboxylase] ligase;
           EC=6.3.4.15;[Rhodococcus erythropolis SK121]
          Length = 284

 Score =  176 bits (446), Expect = 3e-42
 Identities = 108/252 (42%), Positives = 143/252 (56%), Gaps = 8/252 (3%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W +LDVV +TGSTNADLLARAA   D D  VLIAE+Q + RGRH R W + P+ QI+MS+
Sbjct: 31  WNRLDVVEETGSTNADLLARAADP-DADRHVLIAEYQASARGRHSRTWVSPPQAQISMSV 89

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
            +S+  + +A   WL L +G+AV+D    L +V  V A LKWPNDVL G     G LA +
Sbjct: 90  LLSMPGMNLADMGWLPLLSGIAVVDA---LRNVAEVPAELKWPNDVLIGDKKVAGILAEV 146

Query: 146 LAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQW 205
                            +   +E+  P ATSLL       DR+ LV  + REL  +   W
Sbjct: 147 ARTAPDPAVVVGIGLNVSLGVEELPVPTATSLLIEEASTVDRDTLVRAIARELATQFRAW 206

Query: 206 RSA---DPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQT 262
            S+      L A+YR R   +G RVRA LPG K+V G    +D  GR+ ++ EG T G+T
Sbjct: 207 ESSKWDTSVLAAEYRQRCGTLGKRVRAVLPGDKEVFGIATDVDTSGRVVIEIEG-TDGET 265

Query: 263 VVISAGDVVHLR 274
             ++AGD+ HLR
Sbjct: 266 FAVAAGDITHLR 277


>tr|C0ZWV5|C0ZWV5_RHOE4 Tax_Id=234621 (birA)SubName: Full=Biotin
           protein ligase; EC=6.3.4.15;[Rhodococcus erythropolis]
          Length = 284

 Score =  175 bits (443), Expect = 6e-42
 Identities = 108/252 (42%), Positives = 142/252 (56%), Gaps = 8/252 (3%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W +LDVV +TGSTNADLLARAA   D D  VLIAE+Q + RGRH R W + P+ QI+MS+
Sbjct: 31  WNRLDVVEETGSTNADLLARAADP-DADRHVLIAEYQASARGRHSRTWVSPPQAQISMSV 89

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
            +S+  + +    WL L +G+AV+D    L +V  V A LKWPNDVL G     G LA +
Sbjct: 90  LLSMPGMNLTDMGWLPLLSGIAVVDA---LRNVAEVPAELKWPNDVLIGDKKVAGILAEV 146

Query: 146 LAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQW 205
                            +   +E+  P ATSLL       DR+ LV  + REL  +   W
Sbjct: 147 ARTAPDPAVVVGIGLNVSLGVEELPVPTATSLLIEEASTVDRDTLVRAIARELATQFRAW 206

Query: 206 RSA---DPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQT 262
            S+      L A+YR R   +G RVRA LPG K+V G    ID  GR+ ++ EG T G+T
Sbjct: 207 ESSKWDTSVLAAEYRQRCGTLGKRVRAVLPGDKEVFGIATDIDTSGRVVIEIEG-TDGET 265

Query: 263 VVISAGDVVHLR 274
             ++AGD+ HLR
Sbjct: 266 FAVAAGDITHLR 277


>tr|C9N8G9|C9N8G9_9ACTO Tax_Id=591167 SubName:
           Full=Biotin/acetyl-CoA-carboxylase ligase;[Streptomyces
           flavogriseus ATCC 33331]
          Length = 289

 Score =  172 bits (437), Expect = 3e-41
 Identities = 108/254 (42%), Positives = 134/254 (52%), Gaps = 11/254 (4%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W  LDVV  TGSTN+DL  RAA G   +G VL+AE QTAGRGR  R W+A PR+ + +S+
Sbjct: 35  WTSLDVVDATGSTNSDLAVRAAGGGLAEGTVLVAEEQTAGRGRLDRSWTAPPRSGLFLSV 94

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
            ++   VPV  W WL L  GVA       L    GVD  LKWPND+L    G++ K  GI
Sbjct: 95  YLNPGGVPVERWGWLPLLAGVA---AATGLAQSAGVDMALKWPNDLLVTIGGTERKTGGI 151

Query: 146 LAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQW 205
           LAE              +    E+  P A SL   G  + DRE L+  +LR L+    +W
Sbjct: 152 LAERAGEGVVIGIGLNVSLRAAELPAPHAGSLALAGAVSTDRETLLRAVLRSLEQWYARW 211

Query: 206 R-----SADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKG 260
           R     +A+  L A Y A    +   VRAELPG + VVG    ID  GRL L T     G
Sbjct: 212 RDANGDAAESGLQAAYAAGCATLDRTVRAELPGDRSVVGEAVAIDGDGRLVLAT---GDG 268

Query: 261 QTVVISAGDVVHLR 274
               +SAGD+VHLR
Sbjct: 269 IQEPVSAGDIVHLR 282


>tr|Q9EWV9|Q9EWV9_STRCO Tax_Id=1902 SubName: Full=Putative
           ligase;[Streptomyces coelicolor]
          Length = 291

 Score =  172 bits (436), Expect = 4e-41
 Identities = 112/265 (42%), Positives = 141/265 (53%), Gaps = 12/265 (4%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L+  G  WRQ+DVV +TGSTN+DL+ARAA G   +G VL+AE Q+A RGR  R W+A
Sbjct: 31  RRGLVRDGGLWRQVDVVQRTGSTNSDLVARAAEGDLAEGVVLVAEEQSAARGRLDRQWTA 90

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
             R+ +  S+ +  A++PVA W WL L TGVAV      L  V GVD  LKWPND+L   
Sbjct: 91  PARSGLFFSVLLRPAEIPVARWGWLPLLTGVAV---ATGLSRVAGVDTALKWPNDLLVTV 147

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQ-APKEVDGPGATSLLDLGVPAPDREQLVCWL 194
              + K  GILAE                    E+  P A SL   G    DR+ L+  +
Sbjct: 148 GDEERKAGGILAERAGDDGVVIGVGINVSLRADELPVPRAGSLALAGAVNTDRDPLMRGV 207

Query: 195 LRELDARVGQWRSA--DPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGR 249
           LR L+   G+WR A  DP    L   Y A    +G  VRAELPG + +VG    +D  GR
Sbjct: 208 LRSLEDWYGRWRGAGGDPAASGLQETYAAGCATLGRMVRAELPGDRSLVGEAVAVDGDGR 267

Query: 250 LCLKTEGPTKGQTVVISAGDVVHLR 274
           L L T     G    + AGD+VHLR
Sbjct: 268 LVLATGA---GVQEPVGAGDIVHLR 289


>tr|B9VRF4|B9VRF4_9ACTO Tax_Id=67369 SubName: Full=Bpl;[Streptomyces
           toxytricini]
          Length = 292

 Score =  171 bits (432), Expect = 1e-40
 Identities = 112/265 (42%), Positives = 138/265 (52%), Gaps = 14/265 (5%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L   G  W  ++VV  TGSTN DL ARA  G   +GAVL+AE QTAGRGR  R W A
Sbjct: 33  RRALTAGGSLWTSVEVVPGTGSTNTDLAARA--GDLAEGAVLVAEEQTAGRGRLDRSWVA 90

Query: 76  SPRTQITMSIGVSIAD-VPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAG 134
             R+ +  S+ +     VP   W WL+L  GVA     A L    GVD  LKWPND+L  
Sbjct: 91  PARSGLFFSVLLKPGPAVPQERWGWLTLLAGVAA---AAALERAAGVDTALKWPNDLLVT 147

Query: 135 PPGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWL 194
             G + K AGILAE              +   +E+  P A SLL       DRE L+  +
Sbjct: 148 VDGQERKAAGILAERTADGVVIGIGLNVSLTKEELPVPEAGSLLLAKAAVTDREPLLKAV 207

Query: 195 LRELDARVGQWRSA--DPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGR 249
           LR L+     WR+A  DP    L+  Y AR   +G  VRAELPGG+ + GT   +D +GR
Sbjct: 208 LRSLEQSYADWRAAAGDPAASGLLEAYAARCATLGREVRAELPGGRSLTGTAEAVDAEGR 267

Query: 250 LCLKTEGPTKGQTVVISAGDVVHLR 274
           L L+T     G    + AGDVVHLR
Sbjct: 268 LVLRT---ADGSREAVGAGDVVHLR 289


>tr|Q82I28|Q82I28_STRAW Tax_Id=33903 (birA)SubName: Full=Putative
           biotin apo-protein ligase;[Streptomyces avermitilis]
          Length = 291

 Score =  169 bits (427), Expect = 4e-40
 Identities = 110/265 (41%), Positives = 138/265 (52%), Gaps = 14/265 (5%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L+  G  W  LDVV  TGSTN DL ARA + +D +GAVL+AE QTAGRGR  R W+A
Sbjct: 28  RRALVREGSLWSSLDVVPVTGSTNTDLAARAGT-LD-EGAVLVAEEQTAGRGRLDRQWTA 85

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
             R+ +  S+ +  ++VPV  W W+ L TGVAV      L    G D  LKWPND+L   
Sbjct: 86  PARSGLFFSVLLKPSEVPVHRWGWIPLLTGVAV---ATGLSRAAGADTALKWPNDLLVSV 142

Query: 136 PGSKGKLAGILAE-XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWL 194
            G + K  GILAE               T    E+  P A SL   G  + DR+ L+  +
Sbjct: 143 GGQERKAGGILAERTGEDGVVVGVGVNVTLHEDELPVPAAGSLTLAGAVSTDRDPLLRAV 202

Query: 195 LRELDARVGQWRSADPQ-----LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGR 249
           LR L+   G WR AD       L   Y A    +G  VRAELPGG+ + G    +D  GR
Sbjct: 203 LRSLERWYGTWREADGDPAVSGLQEAYAAGCATLGRTVRAELPGGRSLTGEAVAVDGDGR 262

Query: 250 LCLKTEGPTKGQTVVISAGDVVHLR 274
           L L T    +G    + AGD+VHLR
Sbjct: 263 LVLAT---AEGVQQPVGAGDIVHLR 284


>tr|Q0S316|Q0S316_RHOSR Tax_Id=101510 SubName:
           Full=Biotin--[acetyl-CoA-carboxylase] ligase;
           EC=6.3.4.15;[Rhodococcus sp.]
          Length = 282

 Score =  169 bits (427), Expect = 4e-40
 Identities = 104/252 (41%), Positives = 143/252 (56%), Gaps = 9/252 (3%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W +LDVV +TGSTNADLLARAA+  + D  VL+AE Q +GRGRH R W + P+ QI +S+
Sbjct: 32  WARLDVVQETGSTNADLLARAATS-NCDRHVLLAEFQGSGRGRHSRAWVSPPQAQIAVSV 90

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
            +++  + V    WL L TGVAV+D    L   T V A LKWPNDVL       G LA +
Sbjct: 91  LLTMPGMSVQDMGWLPLLTGVAVVDA---LRAATKVPAELKWPNDVLIDGRKVAGILAEV 147

Query: 146 LAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQW 205
            A               +    E+    ATSL+  G    DR+ LV  +LR +  R  QW
Sbjct: 148 SATAPDPAVVVGIGLNVSLTRDELPVEHATSLVLEGAEVSDRDTLVRAVLRAIADRWQQW 207

Query: 206 RSAD---PQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQT 262
             A+    +L   YRAR   +G RVRAELPGG++++G    +D +GR+ +  +G  +  T
Sbjct: 208 HDANWDVTELAEAYRARCGTLGQRVRAELPGGRELIGIATDVDAEGRVVIAPDG--QPGT 265

Query: 263 VVISAGDVVHLR 274
           + ++AGD+ HLR
Sbjct: 266 IAVAAGDITHLR 277


>tr|C1B1A9|C1B1A9_RHOOB Tax_Id=632772 (birA)SubName: Full=Biotin
           protein ligase; EC=6.3.4.15;[Rhodococcus opacus]
          Length = 284

 Score =  165 bits (418), Expect = 4e-39
 Identities = 103/252 (40%), Positives = 140/252 (55%), Gaps = 9/252 (3%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W +LDVV +TGSTNADLL+RAA+  D D  VL+AE Q +GRGRH R W + P+ QI +S 
Sbjct: 34  WSRLDVVQETGSTNADLLSRAATS-DCDRHVLLAEFQGSGRGRHSRAWVSPPQAQIAVSA 92

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGI 145
            +++  + V    WL L TGVAV+D    L     V A LKWPNDVL       G LA +
Sbjct: 93  LLTMPGMSVHDMGWLPLLTGVAVVDA---LRATAKVPAELKWPNDVLIDGRKVAGILAEV 149

Query: 146 LAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQW 205
            A               +    E+    ATSL+  G    DR+ LV  +LR +  R  QW
Sbjct: 150 SATTPDPAVVVGIGLNVSLTRDELPVEHATSLVLEGAEVSDRDTLVRAVLRAIADRWRQW 209

Query: 206 RSAD---PQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQT 262
             A+    +L   YR R   +G RVRAELPGG++++G    +D +GR+ +  +G  +  T
Sbjct: 210 HDANWDVTELAGAYRERCGTLGQRVRAELPGGRELIGIATDVDAEGRVVIAPDG--QPDT 267

Query: 263 VVISAGDVVHLR 274
           V ++AGD+ HLR
Sbjct: 268 VAVAAGDITHLR 279


>tr|B4VAK3|B4VAK3_9ACTO Tax_Id=465541 SubName: Full=Biotin
           apo-protein ligase;[Streptomyces sp. Mg1]
          Length = 284

 Score =  165 bits (418), Expect = 4e-39
 Identities = 109/265 (41%), Positives = 137/265 (51%), Gaps = 14/265 (5%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L+  G  W  ++VV  TGSTN+DL ARAA   +  GAVL+AE QTAGRGR  R W A
Sbjct: 25  RRALVTDGGLWTSVEVVPSTGSTNSDLAARAAELPE--GAVLVAEEQTAGRGRLDRSWVA 82

Query: 76  SPRTQITMSIGVSI-ADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAG 134
             R+ +  S+ +   A VP   W WL+L  GVA       L    GVD  LKWPND+L  
Sbjct: 83  PARSGLFFSVLLKPGAAVPQERWGWLTLLAGVAA---ATGLSRAAGVDTALKWPNDLLVI 139

Query: 135 PPGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWL 194
             G + K  GILAE              T    E+  P A SL        DRE L+  +
Sbjct: 140 VDGEERKTGGILAERVGDGVVLGIGLNVTLTDAELPVPEAGSLALAKASVTDREPLLKAV 199

Query: 195 LRELDARVGQWRSA--DPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGR 249
           LR L+   G+WR+A  DP    L   Y A    +G  VRAELPGG+ + GT   +D  GR
Sbjct: 200 LRSLEEWYGEWRAAGGDPAASGLQETYAASCATLGRHVRAELPGGRQLTGTAEAVDADGR 259

Query: 250 LCLKTEGPTKGQTVVISAGDVVHLR 274
           L ++T     G+   + AGDV+HLR
Sbjct: 260 LVVRT---ADGEREPVGAGDVIHLR 281


>tr|A6WEY2|A6WEY2_KINRD Tax_Id=266940 SubName:
           Full=Biotin--acetyl-CoA-carboxylase ligase;[Kineococcus
           radiotolerans]
          Length = 270

 Score =  164 bits (415), Expect = 1e-38
 Identities = 111/263 (42%), Positives = 143/263 (54%), Gaps = 17/263 (6%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L+G G  W +LDVV  TGSTNADLLA   +    DGAVL+A+HQT GRGR GR WSA
Sbjct: 19  RRALVGPG-PWSRLDVVASTGSTNADLLADEDAP---DGAVLVADHQTGGRGRLGRTWSA 74

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
            PR+ + +S+ +     PVA W+ L L TG+A +D     ++  GV   LKWPNDVL   
Sbjct: 75  PPRSGLAVSV-LLRPQRPVAEWSLLPLVTGLAAVDA----LEALGVRTRLKWPNDVLVEG 129

Query: 136 PGSKGKLAGILAE----XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLV 191
           P   GK+ GILAE                  +   +E+    ATSL   G  + DR+ ++
Sbjct: 130 PDRPGKVCGILAEARTGAGGARVVLGAGINVSLRTEELPVDTATSLALAGARSCDRDTVL 189

Query: 192 CWLLRELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLC 251
              LR L ARV  W + +  L  DYRA S  IG  VRA LP G  +      +D++GRL 
Sbjct: 190 RRYLRALRARVDAWGAGESPL-GDYRALSATIGQDVRAHLPDGSVLEALAVDVDEEGRLV 248

Query: 252 LKTEGPTKGQTVVISAGDVVHLR 274
           ++  G   G    +SA DVVHLR
Sbjct: 249 VEGSG---GARTSLSAADVVHLR 268


>tr|C2ARG0|C2ARG0_TSUPA Tax_Id=521096 SubName: Full=BirA,
           biotin-(Acetyl-CoA-carboxylase) ligase;[Tsukamurella
           paurometabola DSM 20162]
          Length = 269

 Score =  162 bits (411), Expect = 3e-38
 Identities = 110/259 (42%), Positives = 138/259 (53%), Gaps = 14/259 (5%)

Query: 23  GLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQIT 82
           G RW  + VV  TGSTNADL     +G D  G VLIA+ QTAGRGRH R WSA   TQ++
Sbjct: 14  GTRWYDVAVVPSTGSTNADLADGVRAG-DEPGRVLIADVQTAGRGRHLRPWSAPAGTQLS 72

Query: 83  MSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDV-LAGPPGSK-G 140
           +S+ V++         WLSL TGVA +  V    + TGV+AGLKWPNDV L+  PG + G
Sbjct: 73  ISVTVAVPAAAAPRAGWLSLVTGVAAVRAVR---EETGVEAGLKWPNDVLLSAVPGKRGG 129

Query: 141 KLAGILAE-----XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLL 195
           K AGIL+E                   T A  +V    ATSLL  G   PDR  L    L
Sbjct: 130 KAAGILSELATDPHGGLVAVIGTGLNTTLAAADVPVETATSLLLAGAEDPDRTALAIAYL 189

Query: 196 RELDARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTE 255
           R LDA +  W S      ++Y      +G RV   LPG + +VGT   +D +GR+ +  +
Sbjct: 190 RHLDAGLTTWASDPAAARSEYLDVCVTVGQRVTVSLPGDETLVGTAVDVDVEGRIVVADD 249

Query: 256 GPTKGQTVVISAGDVVHLR 274
               G   V+SAGDV HLR
Sbjct: 250 ---DGLRHVLSAGDVTHLR 265


>tr|B5GSW5|B5GSW5_STRCL Tax_Id=443255 SubName: Full=Biotin
           apo-protein ligase;[Streptomyces clavuligerus ATCC
           27064]
          Length = 291

 Score =  162 bits (410), Expect = 4e-38
 Identities = 108/267 (40%), Positives = 139/267 (52%), Gaps = 14/267 (5%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAA-SGIDIDGAVLIAEHQTAGRGRHGRGWS 74
           R  L+  G  W  +DVV  TGSTN+DL A    S   ++GAVL+AE QTAGRGR  R W+
Sbjct: 28  RRALLRPGGLWTSVDVVPATGSTNSDLAAAVTGSPPAVEGAVLVAEEQTAGRGRLDRVWT 87

Query: 75  ASPRTQITMSIGVSIA-DVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLA 133
           ASPR+ +  S+ +    +VPV  W WL L  GVAV      L    GVD  LKWPND+L 
Sbjct: 88  ASPRSGLFFSVALRPGPEVPVERWGWLPLLAGVAV---ATGLSRAAGVDTSLKWPNDLLV 144

Query: 134 GPPGSKGKLAGILAEXXXXXXXXXXXXXXTQ-APKEVDGPGATSLLDLGVPAPDREQLVC 192
              G + K  G+LAE                   +E+  P A SL   G  + DR+ L+ 
Sbjct: 145 TVDGEERKAGGVLAERAGEDTVVVGIGVNVSLRAEELPVPAAGSLALAGAVSTDRDPLLR 204

Query: 193 WLLRELDARVGQWRSA--DP---QLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQ 247
            +LR L+   GQWR A  DP   ++   Y A    +G  VRAELPG + + G    +D  
Sbjct: 205 AVLRALEHWYGQWRGAGGDPLASRVQEAYAAGCATLGRTVRAELPGDRSLTGEAVALDGA 264

Query: 248 GRLCLKTEGPTKGQTVVISAGDVVHLR 274
           GRL L  E  T+     + AGD+VHLR
Sbjct: 265 GRLVLAMEDGTR---EAVGAGDIVHLR 288


>tr|Q5Z151|Q5Z151_NOCFA Tax_Id=37329 (birA)SubName: Full=Putative
           biotin-[acetyl-CoA carboxylase] holoenzyme
           synthetase/biotin operon repressor;[Nocardia farcinica]
          Length = 273

 Score =  160 bits (404), Expect = 2e-37
 Identities = 107/247 (43%), Positives = 128/247 (51%), Gaps = 15/247 (6%)

Query: 31  VVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSIGVSIA 90
           VV  TGSTNADL+ARA S     G VL+AE Q AGRGRH R W++ PR QI MS+ V   
Sbjct: 36  VVEATGSTNADLIARA-SDPGAAGTVLLAETQQAGRGRHARSWTSPPRAQIAMSMLVRPR 94

Query: 91  DVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGILAEXX 150
            +  A   WL L TGVAV+D    L    GV A LKWPNDVL G     G LA + A   
Sbjct: 95  GLEPAVLGWLPLLTGVAVVDA---LRAAAGVPAELKWPNDVLIGGRKVAGILAEVAASGG 151

Query: 151 XXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQWRSA-- 208
                       + +  E+  P A SL   G    DR  +V  +L E   R   WR A  
Sbjct: 152 TPAVVVGVGVNVSLSAAELPVPHAISLELAGAAQVDRTAVVLAILAEFSRRFDAWRQAGW 211

Query: 209 -DPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQTVVISA 267
              +L A YR R   IG++V AELPGG+ + G   GIDD GRL +  +         +SA
Sbjct: 212 DTTELAAAYRERCATIGAQVMAELPGGRTLTGIATGIDDAGRLLIGDD--------AVSA 263

Query: 268 GDVVHLR 274
           GDV HLR
Sbjct: 264 GDVTHLR 270


>tr|B5H4Z5|B5H4Z5_STRPR Tax_Id=457429 SubName: Full=Biotin
           apo-protein ligase;[Streptomyces pristinaespiralis ATCC
           25486]
          Length = 293

 Score =  158 bits (400), Expect = 5e-37
 Identities = 111/266 (41%), Positives = 139/266 (52%), Gaps = 16/266 (6%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           RA ++  GL W  LDVV  TGSTN+DL ARAAS  +  GAVL+AE QTAGRGR  R W+A
Sbjct: 34  RAVVVPGGL-WTSLDVVASTGSTNSDLAARAASLPE--GAVLVAEEQTAGRGRLDRTWTA 90

Query: 76  SPRTQITMSIGVSIA-DVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAG 134
             R+ +  S+ +    DVPV  W WL L  GVA    +A      G D  LKWPND+L  
Sbjct: 91  PARSGLFFSVLLRPGDDVPVTRWGWLPLLAGVAAATALA---RAAGTDMSLKWPNDLLVV 147

Query: 135 PPGSKGKLAGILAEXXXXXXXXXXXXXXTQA-PKEVDGPGATSLLDLGVPAPDREQLVCW 193
             G + K  GILAE                    E+  P + SL+     + DR+ L+  
Sbjct: 148 VGGEERKAGGILAERAGDDGVVLGLGINVSLHADELPVPTSGSLVLADAVSTDRDPLLRA 207

Query: 194 LLRELDARVGQWRSA--DPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQG 248
           +LR L+     WR+A  DP    L   Y A    +G  VRAELPGG D+ G    +D  G
Sbjct: 208 VLRSLEKWYTAWRTAGGDPAACGLQEAYAAGCATLGREVRAELPGGTDLTGEAVALDGDG 267

Query: 249 RLCLKTEGPTKGQTVVISAGDVVHLR 274
           RL L T     G+   +SAGD+VHLR
Sbjct: 268 RLVLAT---ADGERHSVSAGDIVHLR 290


>tr|C9ZGV6|C9ZGV6_STRSW Tax_Id=680198 SubName: Full=Putative
           uncharacterized protein;[Streptomyces scabies]
          Length = 295

 Score =  157 bits (398), Expect = 9e-37
 Identities = 109/265 (41%), Positives = 133/265 (50%), Gaps = 14/265 (5%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  LI  G  W  LDV     STN DL  RA    +  GAVL+AE Q AGRGR  R W+A
Sbjct: 37  RRALIREGGLWSSLDVRPVVDSTNTDLAGRADRLPE--GAVLVAEEQRAGRGRLDRIWTA 94

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
             R+ +  S+ +   +VPV  W WL L TGVAV      L    GVD  LKWPND+L   
Sbjct: 95  PARSGLFFSVLLKPGEVPVERWGWLPLLTGVAV---ATGLSRAAGVDTALKWPNDLLVTV 151

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQ-APKEVDGPGATSLLDLGVPAPDREQLVCWL 194
            G + K  GILAE                   +E+  P A SL   G    DR+ L+  +
Sbjct: 152 GGEERKAGGILAERAGADGVVIGIGINVSLREEELPVPAAGSLALAGAVTTDRDPLLRAV 211

Query: 195 LRELDARVGQWRSA--DPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGR 249
           LR L+   G+WR+A  DP    L   Y A    +G +VRAELPG + VVG    +D  GR
Sbjct: 212 LRSLEEWYGRWRAAGGDPSASGLQETYAAGCATLGRKVRAELPGDRSVVGEAVAVDGDGR 271

Query: 250 LCLKTEGPTKGQTVVISAGDVVHLR 274
           L L TE    G    + AGD+VHLR
Sbjct: 272 LVLATE---DGVQEPVGAGDIVHLR 293


>tr|C1WK69|C1WK69_9ACTO Tax_Id=479435 SubName: Full=BirA,
           biotin-(Acetyl-CoA-carboxylase) ligase;[Kribbella
           flavida DSM 17836]
          Length = 269

 Score =  152 bits (385), Expect = 3e-35
 Identities = 105/264 (39%), Positives = 135/264 (51%), Gaps = 18/264 (6%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L+  G  W Q+DV+T+T STNA + A AASG   +G V+ AE+Q++GRGR GR W+ 
Sbjct: 16  RGRLVRPGSLWTQVDVLTETPSTNAVVAAAAASGAP-EGLVVTAEYQSSGRGRLGRTWTT 74

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
            PR+ +  S+ +  A VP   W WL L   +AV   V     V  + A +KWPNDVL   
Sbjct: 75  PPRSALLTSVLLRPATVPAVRWPWLGLLVPLAVASAVR---RVAEIPAQVKWPNDVLV-- 129

Query: 136 PGSKGKLAGILAE-XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWL 194
                KLAGIL E               T    E     ATSL   G    DR  ++   
Sbjct: 130 --EDRKLAGILLERVDGPAVIVGMGLNVTLRADERPHAAATSLALEGAATTDRATVLAAT 187

Query: 195 LRELDARVGQWRSADPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLC 251
           LREL  R  +W  AD     ++ DY+  S   G RVR ELP G+ + GT  G+D  GRL 
Sbjct: 188 LRELATRYQEWVDADGDPAVVLPDYQELSATFGRRVRVELPDGRFLEGTASGLDTDGRLV 247

Query: 252 LKT-EGPTKGQTVVISAGDVVHLR 274
           L T +GP       ++AGDV HLR
Sbjct: 248 LDTADGPRP-----LAAGDVTHLR 266


>tr|Q47LT6|Q47LT6_THEFY Tax_Id=269800 SubName:
           Full=Biotin--acetyl-CoA-carboxylase ligase;[Thermobifida
           fusca]
          Length = 299

 Score =  148 bits (373), Expect = 7e-34
 Identities = 103/265 (38%), Positives = 134/265 (50%), Gaps = 21/265 (7%)

Query: 19  LIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPR 78
           L+  G  W  + VV   GSTN +LLA+A  G    G VL+ EHQTAGRGR GR +    R
Sbjct: 43  LVQPGALWTSVHVVPSLGSTNTELLAQARQGAPA-GTVLVTEHQTAGRGRLGRSFHTPAR 101

Query: 79  TQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGS 138
             +T S+ +    VP A + WL L  G A   T A +  V  VDA +KWPNDVLA     
Sbjct: 102 AALTFSVLLR-PTVPSARYGWLPLLMGAA---TAAGVRRVAAVDAQVKWPNDVLA----Q 153

Query: 139 KGKLAGILAEXXXXXXXXXXXXXX----TQAPKEVDGPGATSLLDLGVPAPDREQLVCWL 194
             K+AGIL+E                  TQ   E+  P ATSL   G    DR  L+C +
Sbjct: 154 DRKIAGILSEAVFGPSGPAVVIGTGLNVTQTAAELPVPTATSLALAGASCVDRGLLLCAI 213

Query: 195 LRELDARVGQWRSADPQ-----LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGR 249
           L+    R  +W   D       L A+YR+    +G +VR  LPG   V GT  GID  GR
Sbjct: 214 LQAFADRYTRWVEHDGDAERSGLAAEYRSVCSTLGQQVRVHLPGNSVVEGTAMGIDTDGR 273

Query: 250 LCLKTEGPTKGQTVVISAGDVVHLR 274
           L ++++G   G+   ++ GDVVH+R
Sbjct: 274 LQVRSDG---GRDHALTVGDVVHVR 295


>tr|C4ECY6|C4ECY6_STRRS Tax_Id=479432 SubName: Full=BirA,
           biotin-(Acetyl-CoA-carboxylase)
           ligase;[Streptosporangium roseum DSM 43021]
          Length = 274

 Score =  144 bits (364), Expect = 8e-33
 Identities = 101/261 (38%), Positives = 131/261 (50%), Gaps = 18/261 (6%)

Query: 19  LIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPR 78
           L+  G  W  + VV +TGSTNADL      G    GAVLIAE Q AGRGR GR WS  PR
Sbjct: 23  LVRPGGLWSDITVVGRTGSTNADLAQAVRDGAR-QGAVLIAEAQFAGRGRLGRVWSVPPR 81

Query: 79  TQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGS 138
           + +T S+ +   + P     WL L  G+AV   V  L +   VD  LKWPND+L G    
Sbjct: 82  SGLTFSM-LLRPEPPPTRQGWLPLLVGLAVASAVRKLAE---VDVRLKWPNDLLIG---- 133

Query: 139 KGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLREL 198
           + KLAG+LAE              +    E+    ATSL        DR+ L+  +LRE+
Sbjct: 134 ERKLAGVLAERVDSAVIMGVGLNVSVRADELPVETATSLAVEEAACVDRDPLIRAVLREI 193

Query: 199 DARVGQWRSADPQ-----LMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLK 253
           +    +W   D       L A Y   S  +G  VR ELPG + + G   GID  G L ++
Sbjct: 194 ELHYREWSQEDGDADACGLRAAYLGLSATVGREVRVELPGERVLTGLATGIDQAGHLLVR 253

Query: 254 TEGPTKGQTVVISAGDVVHLR 274
               +KG+   +SAGDVVH+R
Sbjct: 254 ----SKGEEHTLSAGDVVHVR 270


>tr|A8M2V4|A8M2V4_SALAI Tax_Id=391037 SubName:
           Full=Biotin--acetyl-CoA-carboxylase ligase;
           EC=6.3.4.15;[Salinispora arenicola]
          Length = 291

 Score =  144 bits (362), Expect = 1e-32
 Identities = 102/274 (37%), Positives = 137/274 (50%), Gaps = 37/274 (13%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W +L++ T+TGSTNAD    A SG + +G V++AE Q AGRGR GR W +  R  I  S+
Sbjct: 30  WARLELRTETGSTNADAAEYARSG-EPEGLVVVAERQHAGRGRRGRAWQSPARAGIATSV 88

Query: 86  ----GVSIAD-----VPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPP 136
               G ++AD     VP + + WL L  GVA+++ V  L +   +DA LKWPND+L G  
Sbjct: 89  LLRPGEAVADRGWSPVPSSAYGWLPLLAGVALVEAVTRLAE---LDATLKWPNDLLVG-- 143

Query: 137 GSKGKLAGILAE-----------XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAP 185
               K  GIL+E                          + P+   G  ATSL   G  A 
Sbjct: 144 --AAKCGGILSEGVPAAGAAAPPAIVLGIGLNVTLRADELPENPTGLPATSLQLAGAAAT 201

Query: 186 DREQLVCWLLRELDARVGQWRSA-----DPQLMADYRARSPIIGSRVRAELPGGKDVVGT 240
           DR+ L+  LLR L    G+WR A     D  L   Y A    +G  VR  LP G ++ GT
Sbjct: 202 DRDPLLRALLRSLGDWYGRWRDAGGNAVDSGLREAYLAACGTVGRPVRVLLPDGGELTGT 261

Query: 241 VRGIDDQGRLCLKTEGPTKGQTVVISAGDVVHLR 274
             G+D  G+L + T   T+     +SAGDV+HLR
Sbjct: 262 ATGVDSDGQLVVATPDTTR----YLSAGDVLHLR 291


>tr|C7Q0X6|C7Q0X6_CATAD Tax_Id=479433 SubName:
           Full=Biotin/acetyl-CoA-carboxylase ligase;[Catenulispora
           acidiphila]
          Length = 308

 Score =  143 bits (361), Expect = 2e-32
 Identities = 106/287 (36%), Positives = 141/287 (49%), Gaps = 39/287 (13%)

Query: 19  LIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPR 78
           ++  G  WR+++VV +TGSTNAD+ A AA G + +G VL+AE Q+AGRGR GR WSA  R
Sbjct: 30  VVRPGGLWRRIEVVRETGSTNADV-ADAARGGEGEGFVLVAEAQSAGRGRLGRTWSAPAR 88

Query: 79  TQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVL------ 132
           + + +S+ V   DV  A W WL L  G AV   V     V+GV   LKWPND++      
Sbjct: 89  SGLFLSVLVRPGDVAPARWGWLPLLAGTAVRTAVEA---VSGVPVRLKWPNDLIVVDDAD 145

Query: 133 ----------------AGPPGSKGKLAGILAE----XXXXXXXXXXXXXXTQAPKEVDGP 172
                           A   G+  KL GIL E                  +    E+   
Sbjct: 146 SDDGADSDADSNKDTAAHAYGAARKLGGILVERVETSSGPAAVVGVGLNVSLRRDELPAG 205

Query: 173 GATSLLDLGVPAPDREQLVCWLLRELDARVGQW--RSADPQ---LMADYRARSPIIGSRV 227
            ATSL+  G  A DR+ ++  +LRE++     W     DP    L + Y A    +G RV
Sbjct: 206 HATSLVLEGAKAADRDTVLRSVLREIERWYTDWSVTGGDPMASGLASAYVASCATLGRRV 265

Query: 228 RAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQTVVISAGDVVHLR 274
           R ELPGG  V G   G+D  GRL +++ G  +       AGDVVHLR
Sbjct: 266 RVELPGGAPVEGEAVGLDGDGRLLVRSGGSER----AFGAGDVVHLR 308


>tr|C4RPP4|C4RPP4_9ACTO Tax_Id=219305 SubName:
           Full=Biotin-acetyl-CoA-carboxylase
           ligase;[Micromonospora sp. ATCC 39149]
          Length = 291

 Score =  143 bits (360), Expect = 2e-32
 Identities = 104/275 (37%), Positives = 137/275 (49%), Gaps = 39/275 (14%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           W +L++  +TGSTNAD+   A SG + +G V+IAE QTAGRGR GR W + PR  I  S+
Sbjct: 30  WARLELRAETGSTNADVAEAARSG-EPEGLVVIAERQTAGRGRRGRVWQSPPRAGIATSV 88

Query: 86  ----GVSIAD-----VPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPP 136
               G ++A+      P   + WL L  GVA+++ VA L +   +DA LKWPND+L G  
Sbjct: 89  LLRPGEAVAERDWPPAPATGYGWLPLLAGVALVEAVARLAE---LDAALKWPNDLLIG-- 143

Query: 137 GSKGKLAGILAE-----------XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAP 185
               K AGILAE                          + P    G  ATSL   G  A 
Sbjct: 144 --DAKCAGILAEAVPGPAPDQPPAIVLGIGLNVTLRADELPANPTGLPATSLQLAGAVAT 201

Query: 186 DREQLVCWLLRELDARVGQWRSADPQLMAD-----YRARSPIIGSRVRAELPGGKDVVGT 240
           DR+ L+  LLR +     +WR A    +A      Y A    +G  VR  LPGG +V G 
Sbjct: 202 DRDPLLRALLRSVADWYDRWRHAGGDAVASGLRDAYLAACATVGRPVRVLLPGGAEVTGV 261

Query: 241 VRGIDDQGRLCLKT-EGPTKGQTVVISAGDVVHLR 274
             G+D  GRL + T  GP       ++AGDV+HLR
Sbjct: 262 ATGVDADGRLLVDTPAGPR-----TLAAGDVLHLR 291


>tr|C7MUU8|C7MUU8_SACVD Tax_Id=471857 SubName: Full=BirA,
           biotin-(Acetyl-CoA-carboxylase)
           ligase;[Saccharomonospora viridis]
          Length = 275

 Score =  137 bits (346), Expect = 1e-30
 Identities = 102/271 (37%), Positives = 135/271 (49%), Gaps = 23/271 (8%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R+ L+     +  +DVV++TGSTNADL  RAA G   D  VL+AE QTAG GR GR W++
Sbjct: 13  RSRLLAPAGPYAAIDVVSRTGSTNADLRVRAAEGAS-DRTVLLAEEQTAGVGRRGRTWAS 71

Query: 76  SPRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGP 135
              + + +S+ +  A+VP A+   L++  G+A+ D  A L    GVDA LKWPND+LAGP
Sbjct: 72  PAGSGVYLSVLLRPAEVPPASLGSLAMVAGLALTDVAAEL----GVDAVLKWPNDMLAGP 127

Query: 136 PGSKGKLAGILAEXXXXXXXXXXXXXXTQA--PKEVDGPG-----ATSLLDLGVPAPDRE 188
              + K AG+LAE                    +E   PG     ATSL D G    DR 
Sbjct: 128 --DRAKCAGVLAEAVSTGDSAVVCGIGLNVLPLREPVSPGPGGQPATSLADQGARTTDRT 185

Query: 189 QLVCWLLRELDARVGQWRSADPQ-----LMADYRARSPIIGSRVRAELPGGKDVVGTVRG 243
           ++   LL  L  R   WR A        L+  YR R   +G  VR E+ GG+     V  
Sbjct: 186 EVAASLLAALHERELAWRRARGDLEMAGLLDTYRERCATLGREVRLEITGGRSRYCRVVD 245

Query: 244 IDDQGRLCLKTEGPTKGQTVVISAGDVVHLR 274
           I   G L +  +G        + A DVVHLR
Sbjct: 246 IHPTGALVVDEDGFWS----TVFAADVVHLR 272


>tr|D0L8T0|D0L8T0_9ACTO Tax_Id=526226 SubName:
           Full=Biotin/acetyl-CoA-carboxylase ligase;[Gordonia
           bronchialis DSM 43247]
          Length = 271

 Score =  137 bits (346), Expect = 1e-30
 Identities = 104/255 (40%), Positives = 127/255 (49%), Gaps = 20/255 (7%)

Query: 25  RWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMS 84
           RW +++VV  TGSTNADL+ARA     I G V I   QTAGRGRH R W A   TQ+ +S
Sbjct: 29  RWHRIEVVDATGSTNADLMARADEP-GIVGTVRITTDQTAGRGRHARVWEAPRGTQVAIS 87

Query: 85  IGVSIADVPVATWAWLSLATGVAVLDTVAPLID-VTGVDAGLKWPNDVLAGPPGSKGKLA 143
             +   D P     WLSLATG A     A  ID  TG+ A LKWPNDVL        K+A
Sbjct: 88  AVLPAGDAPDRL-GWLSLATGTAA----AHAIDRATGLSAVLKWPNDVLVDGK----KVA 138

Query: 144 GILAEXXXXXXXXXXXXXX----TQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELD 199
           GILAE                    + +E+  P ATSL      A D   +    LR L 
Sbjct: 139 GILAEYASAPGGGIVVVGIGINTEMSAEELPVPTATSLRIATGRAVDVAAVATEYLRALA 198

Query: 200 ARVGQWRSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTK 259
            +  +W      + ADYR R   +G RVR  LPG K +VGT   ID  GR+ ++ +    
Sbjct: 199 DQ--RWPDDIDAVAADYRDRCDTLGRRVRLALPGDKTIVGTAVDIDADGRIVVEDD---H 253

Query: 260 GQTVVISAGDVVHLR 274
           G     +AGDV HLR
Sbjct: 254 GHRTTAAAGDVTHLR 268


>tr|C1YKR2|C1YKR2_NOCDA Tax_Id=446468 SubName: Full=BirA,
           biotin-(Acetyl-CoA-carboxylase) ligase;[Nocardiopsis
           dassonvillei subsp. dassonvillei DSM 43111]
          Length = 286

 Score =  137 bits (346), Expect = 1e-30
 Identities = 105/273 (38%), Positives = 135/273 (49%), Gaps = 24/273 (8%)

Query: 17  AELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSAS 76
           A L   G  W +++V+ +  STN +L ARA  G    G+VL+ EHQTAGRGR GRG+S  
Sbjct: 20  AALARPGGMWHRVEVLPEAASTNTELTARAVEGAP-HGSVLVTEHQTAGRGRLGRGFSTP 78

Query: 77  PRTQITMSIGVSIADVPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVL---- 132
           PR  +T S+ V  A VPV    WL    GVA +  V     VTGV A LKWPNDV+    
Sbjct: 79  PRAALTFSLLVRPA-VPVTRLGWLPALMGVAAVGAVH---RVTGVKAALKWPNDVIVPAH 134

Query: 133 --AGPPGSKGKLAGILAE----XXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPD 186
             + P  + GKLAGIL+E                  +Q   E+    A SL   G  A D
Sbjct: 135 LRSEPATADGKLAGILSEADFSSGHPGVVVGMGLNVSQERAELPVDTAVSLRGEGSDALD 194

Query: 187 REQLVCWLLRELDARVGQWRSADPQ-----LMADYRARSPIIGSRVRAELPGGKDVVGTV 241
           R  L+  +L   +     W +A        L A YR     IG RVR  LPG + + G  
Sbjct: 195 RGVLLAAVLGGFEELYTVWTAAGGDAEASGLAAAYRDACVTIGRRVRVHLPGDRVLEGAA 254

Query: 242 RGIDDQGRLCLKTEGPTKGQTVVISAGDVVHLR 274
            G+D   +L ++  GP  G    +SAGDVVH+R
Sbjct: 255 TGVDADAQLLVR--GP--GGERALSAGDVVHVR 283


>tr|C2A4R6|C2A4R6_THECU Tax_Id=471852 SubName: Full=BirA,
           biotin-(Acetyl-CoA-carboxylase) ligase;[Thermomonospora
           curvata DSM 43183]
          Length = 289

 Score =  137 bits (345), Expect = 1e-30
 Identities = 101/270 (37%), Positives = 138/270 (51%), Gaps = 31/270 (11%)

Query: 26  WRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSI 85
           WR++ VV +TGSTN DL   A  G + +GAVL+AE Q AGRGR GR W+A PR+ +T S+
Sbjct: 30  WRRVRVVAETGSTNVDLAEAARRG-EPEGAVLVAESQRAGRGRLGRSWTAPPRSGLTFSV 88

Query: 86  GVSIADVPVATWAWLSLATGVAVLDTVAPLI-----DVT-----------GVDAGLKWPN 129
            +    V  A   WL L TG+A  + +  +      D+T            +D  LKWPN
Sbjct: 89  -LLRPPVEAAALGWLPLLTGLAAAEALRRVTGRVTEDLTEGSARRNGRAAALDVRLKWPN 147

Query: 130 DVLAGPPGSKGKLAGILAEXXXXXXXXXXXXXXTQAPKEVDGPGATSLLDLGVPAPDREQ 189
           D++ G      KL GILAE              +   +E+  P ATSLL  G    +RE 
Sbjct: 148 DLMVG----DRKLGGILAERVGDAVVMGVGLNVSLREEELPVPTATSLLLEGAAFREREA 203

Query: 190 LVCWLLRELDARVGQW--RSADPQ---LMADYRARSPIIGSRVRAELPGGKDVVGTVRGI 244
           L+  +LREL+    +W  +  D +   L A YR     +G +VR  +PG +++ G V  +
Sbjct: 204 LLRAILRELEDWYRRWTAQGGDAEGSGLRAAYRDLCATLGRQVRVVMPGDQEITGRVADV 263

Query: 245 DDQGRLCLKTEGPTKGQTVVISAGDVVHLR 274
           D  G  CL    P   QTV   AGDVVH+R
Sbjct: 264 DAAG--CLVVVTPEGEQTV--GAGDVVHVR 289


>tr|A4X384|A4X384_SALTO Tax_Id=369723 SubName:
           Full=Biotin--acetyl-CoA-carboxylase ligase;
           EC=6.3.4.15;[Salinispora tropica]
          Length = 291

 Score =  136 bits (342), Expect = 3e-30
 Identities = 99/284 (34%), Positives = 141/284 (49%), Gaps = 37/284 (13%)

Query: 16  RAELIGTGLRWRQLDVVTQTGSTNADLLARAASGIDIDGAVLIAEHQTAGRGRHGRGWSA 75
           R  L+     W +L+++ +TGSTNAD+   A SG + +G VL+AE Q+AGRGR GR W +
Sbjct: 20  RRALVAPHGPWARLELLAETGSTNADVAEYARSG-EPEGLVLVAERQSAGRGRRGREWQS 78

Query: 76  SPRTQITMSI----GVSIAD-----VPVATWAWLSLATGVAVLDTVAPLIDVTGVDAGLK 126
             R  I  S+    G ++A+     VP + + WL L  GVA+++ V  L +   ++A LK
Sbjct: 79  PARAGIATSVLLRPGEAVAERGWAPVPPSAYGWLPLLAGVALVEAVTRLAE---LEATLK 135

Query: 127 WPNDVLAGPPGSKGKLAGILAE-----------XXXXXXXXXXXXXXTQAPKEVDGPGAT 175
           WPND+L G      K  GILAE                          + P+   G  AT
Sbjct: 136 WPNDLLVG----AAKCGGILAEGVPAVGVAAAPAIVLGIGLNVTLRADELPENPTGLPAT 191

Query: 176 SLLDLGVPAPDREQLVCWLLRELDARVGQWRSADPQ-----LMADYRARSPIIGSRVRAE 230
           SL   G  A DR+ L+  LLR L     +WR+A+       L A Y      +   VR  
Sbjct: 192 SLRLAGAAATDRDPLLRALLRSLGDWYERWRAAEGSAVASGLRAAYLGVCATVDRPVRVL 251

Query: 231 LPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQTVVISAGDVVHLR 274
           LP G ++ GT  G+D  G+L + T   T+     +SAGD++HLR
Sbjct: 252 LPDGGELTGTATGVDPDGQLVVATPEATRH----LSAGDILHLR 291


  Database: Amellifera_nr
    Posted date:  Jan 15, 2010  5:10 AM
  Number of letters in database: 3,808,957,724
  Number of sequences in database:  11,153,314
  
Lambda     K      H
   0.317    0.136    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 11153314
Number of Hits to DB: 2,003,055,821
Number of extensions: 83835068
Number of successful extensions: 195087
Number of sequences better than 10.0: 1786
Number of HSP's gapped: 194794
Number of HSP's successfully gapped: 1806
Length of query: 274
Length of database: 3,808,957,724
Length adjustment: 135
Effective length of query: 139
Effective length of database: 2,303,260,334
Effective search space: 320153186426
Effective search space used: 320153186426
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 79 (35.0 bits)