BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= ML0912 (490 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,153,314 sequences; 3,808,957,724 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|P57995|MURD_MYCLE Tax_Id=1769 (murD)RecName: Full=UDP-N-acety... 807 0.0 sp|B8ZQP8|MURD_MYCLB Tax_Id=561304 (murD)RecName: Full=UDP-N-ace... 807 0.0 sp|Q73YQ6|MURD_MYCPA Tax_Id=1770 (murD)RecName: Full=UDP-N-acety... 619 e-175 sp|A0QF50|MURD_MYCA1 Tax_Id=243243 (murD)RecName: Full=UDP-N-ace... 618 e-175 tr|B2HGR8|B2HGR8_MYCMM Tax_Id=216594 (murD)RecName: Full=UDP-N-a... 607 e-171 tr|A0PTI9|A0PTI9_MYCUA Tax_Id=362242 (murD)RecName: Full=UDP-N-a... 604 e-171 sp|C1AQ71|MURD_MYCBT Tax_Id=561275 (murD)RecName: Full=UDP-N-ace... 588 e-166 sp|A1KKJ8|MURD_MYCBP Tax_Id=410289 (murD)RecName: Full=UDP-N-ace... 588 e-166 sp|Q7VEP7|MURD_MYCBO Tax_Id=1765 (murD)RecName: Full=UDP-N-acety... 588 e-166 tr|C6DPQ3|C6DPQ3_MYCTK Tax_Id=478434 RecName: Full=UDP-N-acetylm... 588 e-166 tr|A5WPC7|A5WPC7_MYCTF Tax_Id=336982 RecName: Full=UDP-N-acetylm... 588 e-166 tr|A4KIT3|A4KIT3_MYCTU Tax_Id=395095 RecName: Full=UDP-N-acetylm... 586 e-165 tr|A2VJQ2|A2VJQ2_MYCTU Tax_Id=348776 RecName: Full=UDP-N-acetylm... 586 e-165 sp|O06222|MURD_MYCTU Tax_Id=1773 (murD)RecName: Full=UDP-N-acety... 585 e-165 sp|A5U4I2|MURD_MYCTA Tax_Id=419947 (murD)RecName: Full=UDP-N-ace... 585 e-165 sp|A0R018|MURD_MYCS2 Tax_Id=246196 (murD)RecName: Full=UDP-N-ace... 516 e-144 tr|Q1B6W9|Q1B6W9_MYCSS Tax_Id=164756 RecName: Full=UDP-N-acetylm... 509 e-142 tr|A1UI56|A1UI56_MYCSK Tax_Id=189918 RecName: Full=UDP-N-acetylm... 509 e-142 tr|A3Q1M0|A3Q1M0_MYCSJ Tax_Id=164757 RecName: Full=UDP-N-acetylm... 507 e-141 tr|A4TBF3|A4TBF3_MYCGI Tax_Id=350054 RecName: Full=UDP-N-acetylm... 502 e-140 sp|A1TAX0|MURD_MYCVP Tax_Id=350058 (murD)RecName: Full=UDP-N-ace... 493 e-137 tr|B1MP35|B1MP35_MYCA9 Tax_Id=561007 RecName: Full=UDP-N-acetylm... 473 e-131 tr|C1AU57|C1AU57_RHOOB Tax_Id=632772 (murD)RecName: Full=UDP-N-a... 405 e-111 sp|Q0SHR9|MURD_RHOSR Tax_Id=101510 (murD)RecName: Full=UDP-N-ace... 404 e-110 tr|C3JJ50|C3JJ50_RHOER Tax_Id=596309 (murD)RecName: Full=UDP-N-a... 391 e-106 tr|C1A0X7|C1A0X7_RHOE4 Tax_Id=234621 (murD)RecName: Full=UDP-N-a... 389 e-106 tr|C2ATS3|C2ATS3_TSUPA Tax_Id=521096 RecName: Full=UDP-N-acetylm... 366 3e-99 sp|Q5YYY1|MURD_NOCFA Tax_Id=37329 (murD)RecName: Full=UDP-N-acet... 361 1e-97 tr|D0LAT4|D0LAT4_9ACTO Tax_Id=526226 SubName: Full=UDP-N-acetylm... 344 2e-92 tr|C8XGY8|C8XGY8_NAKMY Tax_Id=479431 SubName: Full=UDP-N-acetylm... 319 6e-85 tr|C6WDE4|C6WDE4_ACTMD Tax_Id=446462 RecName: Full=UDP-N-acetylm... 318 1e-84 tr|A4FLW2|A4FLW2_SACEN Tax_Id=405948 (murD)RecName: Full=UDP-N-a... 305 9e-81 sp|Q8FNT8|MURD_COREF Tax_Id=152794 (murD)RecName: Full=UDP-N-ace... 296 3e-78 tr|C8NQ14|C8NQ14_COREF Tax_Id=196164 (murD)SubName: Full=UDP-N-a... 296 3e-78 tr|C7MV95|C7MV95_SACVD Tax_Id=471857 RecName: Full=UDP-N-acetylm... 291 1e-76 tr|C0WK95|C0WK95_9CORY Tax_Id=525260 (murD)RecName: Full=UDP-N-a... 288 1e-75 tr|C6RAX1|C6RAX1_9CORY Tax_Id=553206 (murD)RecName: Full=UDP-N-a... 287 2e-75 sp|Q47QX1|MURD_THEFY Tax_Id=269800 (murD)RecName: Full=UDP-N-ace... 286 3e-75 tr|A4QFM5|A4QFM5_CORGB Tax_Id=340322 RecName: Full=UDP-N-acetylm... 285 7e-75 tr|A1SL82|A1SL82_NOCSJ Tax_Id=196162 RecName: Full=UDP-N-acetylm... 285 7e-75 tr|A3TJS4|A3TJS4_9MICO Tax_Id=313589 (murD)RecName: Full=UDP-N-a... 285 7e-75 sp|Q9S2W9|MURD_STRCO Tax_Id=1902 (murD)RecName: Full=UDP-N-acety... 283 5e-74 sp|Q82AD8|MURD_STRAW Tax_Id=33903 (murD)RecName: Full=UDP-N-acet... 283 5e-74 tr|Q6M3S0|Q6M3S0_CORGL Tax_Id=1718 (murD)RecName: Full=UDP-N-ace... 282 6e-74 tr|C2BNI7|C2BNI7_9CORY Tax_Id=525264 (murD)RecName: Full=UDP-N-a... 281 2e-73 tr|C0XS04|C0XS04_9CORY Tax_Id=525263 (murD)RecName: Full=UDP-N-a... 280 2e-73 tr|C1YQK2|C1YQK2_NOCDA Tax_Id=446468 RecName: Full=UDP-N-acetylm... 279 5e-73 tr|C7QI97|C7QI97_CATAD Tax_Id=479433 RecName: Full=UDP-N-acetylm... 278 1e-72 tr|B1W0I8|B1W0I8_STRGG Tax_Id=455632 RecName: Full=UDP-N-acetylm... 277 3e-72 tr|C9YVC5|C9YVC5_STRSW Tax_Id=680198 (murD)SubName: Full=Putativ... 275 1e-71 >sp|P57995|MURD_MYCLE Tax_Id=1769 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium leprae] Length = 490 Score = 807 bits (2084), Expect = 0.0 Identities = 426/490 (86%), Positives = 427/490 (87%) Query: 1 VLDTXXXXXXXXXXXXXXTGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXX 60 +LDT TGRAVLAALTRFGMAATLCDDDPAALQQYADNG Sbjct: 1 MLDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQQYADNGVATVSAATA 60 Query: 61 XQQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWL 120 QQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWL Sbjct: 61 TQQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWL 120 Query: 121 VVXXXXXXXXXXSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLH 180 VV SMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLH Sbjct: 121 VVTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLH 180 Query: 181 WAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVA 240 WAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVA Sbjct: 181 WAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVA 240 Query: 241 PVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXX 300 PVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVS Sbjct: 241 PVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAALARS 300 Query: 301 XXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG 360 TAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG Sbjct: 301 VGVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG 360 Query: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA Sbjct: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420 Query: 421 VVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480 VVSGTDVISISDVGGTIGTRVM RDLAQPGDTVLLAPAGASFDQFSGYADRGDT Sbjct: 421 VVSGTDVISISDVGGTIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480 Query: 481 FATAVRAAIR 490 FATAVRAAIR Sbjct: 481 FATAVRAAIR 490 >sp|B8ZQP8|MURD_MYCLB Tax_Id=561304 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium leprae] Length = 490 Score = 807 bits (2084), Expect = 0.0 Identities = 426/490 (86%), Positives = 427/490 (87%) Query: 1 VLDTXXXXXXXXXXXXXXTGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXX 60 +LDT TGRAVLAALTRFGMAATLCDDDPAALQQYADNG Sbjct: 1 MLDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQQYADNGVATVSAATA 60 Query: 61 XQQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWL 120 QQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWL Sbjct: 61 TQQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWL 120 Query: 121 VVXXXXXXXXXXSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLH 180 VV SMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLH Sbjct: 121 VVTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLH 180 Query: 181 WAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVA 240 WAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVA Sbjct: 181 WAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVA 240 Query: 241 PVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXX 300 PVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVS Sbjct: 241 PVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAALARS 300 Query: 301 XXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG 360 TAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG Sbjct: 301 VGVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG 360 Query: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA Sbjct: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420 Query: 421 VVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480 VVSGTDVISISDVGGTIGTRVM RDLAQPGDTVLLAPAGASFDQFSGYADRGDT Sbjct: 421 VVSGTDVISISDVGGTIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480 Query: 481 FATAVRAAIR 490 FATAVRAAIR Sbjct: 481 FATAVRAAIR 490 >sp|Q73YQ6|MURD_MYCPA Tax_Id=1770 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium paratuberculosis] Length = 489 Score = 619 bits (1595), Expect = e-175 Identities = 329/472 (69%), Positives = 356/472 (75%), Gaps = 7/472 (1%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGRAVLAAL RFG A TLCDDDPA L+ Y D+G ER +Y LVVTSP Sbjct: 25 TGRAVLAALRRFGAAPTLCDDDPATLRGYVDSGVDTVSTSAAA----ERISRYALVVTSP 80 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GFAPT P+ +AA+AA VP+WGDVELAWRLD AG+YGPPRRWLVV SMLHAM Sbjct: 81 GFAPTAPLPLAAAAAGVPVWGDVELAWRLDVAGHYGPPRRWLVVTGTNGKTTTTSMLHAM 140 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RRSLLCGNIG PVLDVL + P++ LAVELSSFQLHWAPSLRPE G VLNIAED Sbjct: 141 LTAAGRRSLLCGNIGSPVLDVLDQ---PAELLAVELSSFQLHWAPSLRPEGGAVLNIAED 197 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH T+ADY AKARVL GRVAVVGLDDSRAAALLST APVRVGFR GEPA GELGV Sbjct: 198 HLDWHGTLADYAAAKARVLDGRVAVVGLDDSRAAALLSTARAPVRVGFRLGEPAAGELGV 257 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 R G LVDRAFA+DL L+PV SIPV + IA+A+ FR+G Sbjct: 258 RGGQLVDRAFADDLTLLPVDSIPVPGPVGVLDALAAAALARCVDVPASPIAEAIVSFRVG 317 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGASVDAEVARMA Sbjct: 318 RHRAEVVAVADGITYVDDSKATNPHAAEASVLAYPRVVWIAGGLLKGASVDAEVARMASW 377 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIG 438 LVGAVLIGRDR VAEALSRHAP+VPVV VV GEDAGM A VV G +V + +GG +G Sbjct: 378 LVGAVLIGRDRREVAEALSRHAPDVPVVHVVTGEDAGMDATPVVFGANVTKVKHLGGDLG 437 Query: 439 TRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 VM RDLA+PGDTVLLAPAGASFDQF+GYADRG+ FA AVRAAIR Sbjct: 438 AAVMSAAVAAARDLAKPGDTVLLAPAGASFDQFAGYADRGEAFAAAVRAAIR 489 >sp|A0QF50|MURD_MYCA1 Tax_Id=243243 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium avium] Length = 489 Score = 618 bits (1593), Expect = e-175 Identities = 329/472 (69%), Positives = 356/472 (75%), Gaps = 7/472 (1%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGRAVLAAL RFG A TLCDDDPA L+ Y D+G ER +Y LVVTSP Sbjct: 25 TGRAVLAALRRFGAAPTLCDDDPATLRGYVDSGVDTVSTSAAA----ERISRYALVVTSP 80 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GFAPT P+ +AA+AA VP+WGDVELAWRLDAAG+YGPPRRWLVV SMLHAM Sbjct: 81 GFAPTAPLPLAAAAAGVPVWGDVELAWRLDAAGHYGPPRRWLVVTGTNGKTTTTSMLHAM 140 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RRSLLCGNIG PVLDVL + P++ LAVELSSFQLHWAPSLRPE G VLNIAED Sbjct: 141 LTAAGRRSLLCGNIGSPVLDVLDQ---PAELLAVELSSFQLHWAPSLRPEGGAVLNIAED 197 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH T+ADY AKARVL GRVAVVGLDDSRAAALLST APVRVGFR GEPA GELGV Sbjct: 198 HLDWHGTLADYAAAKARVLDGRVAVVGLDDSRAAALLSTARAPVRVGFRLGEPAAGELGV 257 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 R G LVDRAFA+DL L+PV SIPV + IA+A+ FR+G Sbjct: 258 RGGQLVDRAFADDLTLLPVDSIPVPGPVGVLDALAAAALARCVDVPASPIAEAIVSFRVG 317 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGASVDA VARMA + Sbjct: 318 RHRAEVVAVADGITYVDDSKATNPHAAEASVLAYPRVVWIAGGLLKGASVDAVVARMASR 377 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIG 438 LVGAVLIGRDR VAEALSRHAP+VPVV VV GEDAGM A VV G +V + +GG +G Sbjct: 378 LVGAVLIGRDRREVAEALSRHAPDVPVVHVVTGEDAGMDATPVVFGANVTKVKHLGGDLG 437 Query: 439 TRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 VM RDLA+PGDTVLLAPA ASFDQF+GYADRGD FA AVRAAIR Sbjct: 438 AAVMSAAVAAARDLAKPGDTVLLAPAAASFDQFAGYADRGDAFAAAVRAAIR 489 >tr|B2HGR8|B2HGR8_MYCMM Tax_Id=216594 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium marinum] Length = 488 Score = 607 bits (1565), Expect = e-171 Identities = 325/476 (68%), Positives = 357/476 (75%), Gaps = 10/476 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGR----KYVLV 74 TGRAVLAALTRFG T+CDDDPA L+ +A++G QQ+ + +Y LV Sbjct: 19 TGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQPEASPESRYALV 78 Query: 75 VTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSM 134 VTSPGF P+TPVL AA+AA VPIWGDVELAWRLDAAG YGPPRRWLVV SM Sbjct: 79 VTSPGFQPSTPVLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRRWLVVTGTNGKTTTTSM 138 Query: 135 LHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLN 194 LHAML A RS+LCGNIG PVLDVL E P+D LAVELSSFQLHWAPSLRPEAGVVLN Sbjct: 139 LHAMLVAGQHRSVLCGNIGSPVLDVLEE---PADLLAVELSSFQLHWAPSLRPEAGVVLN 195 Query: 195 IAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVG 254 IAEDHLDWH TMA YT AKARVLTGRVAVVGLDDSRAAAL T APVRVGFR G PAVG Sbjct: 196 IAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGFRIGAPAVG 255 Query: 255 ELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVAL 314 ELG+RDG+LVDRAF++DL L+P +SIPV AIADAVA Sbjct: 256 ELGLRDGHLVDRAFSDDLVLLPASSIPVPGPVGVLDTLAAAALARAVGVSADAIADAVAS 315 Query: 315 FRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVAR 374 F++GRHR+EVV V DGI YVDDSKATNPHAA SVLAYPRVVWVAGGLLKGASVDAEVAR Sbjct: 316 FQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGASVDAEVAR 375 Query: 375 MAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVG 434 MA +LVGAVLIG+DRA VAEALSRHAP+VPVVQVV EDA M G V + DVG Sbjct: 376 MASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADM---GEACGASVTKVDDVG 432 Query: 435 GTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 G++G RVM R++A+ GDTVLLAPAGASFDQF+ Y DRGD FA AVRAA+R Sbjct: 433 GSLGARVMRAAVAAARNMARSGDTVLLAPAGASFDQFTSYGDRGDAFAAAVRAAVR 488 >tr|A0PTI9|A0PTI9_MYCUA Tax_Id=362242 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium ulcerans] Length = 488 Score = 604 bits (1557), Expect = e-171 Identities = 324/476 (68%), Positives = 356/476 (74%), Gaps = 10/476 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFE----RGRKYVLV 74 TGRAVLAALTRFG T+CDDDPA L+ +A++G QQ+ + +Y LV Sbjct: 19 TGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQPEPSSESRYALV 78 Query: 75 VTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSM 134 VTSPGF P+TPVL AA+AA VPIWGDVELAWRLDAAG YGPPRRWLVV SM Sbjct: 79 VTSPGFQPSTPVLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRRWLVVTGTNGKTTTTSM 138 Query: 135 LHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLN 194 LHAML A RS+LCGNIG PVLDVL E P+D LAVELSSFQL WAPSLRPEAGVVLN Sbjct: 139 LHAMLVAGQHRSVLCGNIGSPVLDVLEE---PADLLAVELSSFQLRWAPSLRPEAGVVLN 195 Query: 195 IAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVG 254 IAEDHLDWH TMA YT AKARVLTGRVAVVGLDDSRAAAL T APVRVGFR G PAVG Sbjct: 196 IAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGFRIGTPAVG 255 Query: 255 ELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVAL 314 ELG+RDG+LVDRAF++DL L+P +SIPV AIADAVA Sbjct: 256 ELGLRDGHLVDRAFSDDLVLLPASSIPVPGPVGVLDTLAAAALARAVGVSADAIADAVAS 315 Query: 315 FRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVAR 374 F++GRHR+EVV V DGI YVDDSKATNPHAA SVLAYPRVVWVAGGLLKGASVDAEVAR Sbjct: 316 FQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGASVDAEVAR 375 Query: 375 MAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVG 434 MA +LVGAVLIG+DRA VAEALSRHAP+VPVVQVV EDA M G V + DVG Sbjct: 376 MAARLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADM---GEAYGASVTKVDDVG 432 Query: 435 GTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 G++G RVM R++A+ GDTVLLAPAGASFDQF+ Y DRGD FA AVRAA+R Sbjct: 433 GSLGARVMRAAVAAARNMARSGDTVLLAPAGASFDQFTSYGDRGDAFAAAVRAAVR 488 >sp|C1AQ71|MURD_MYCBT Tax_Id=561275 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 588 bits (1517), Expect = e-166 Identities = 319/475 (67%), Positives = 348/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 19 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P TP+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 75 GFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 135 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 191 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA GELGV Sbjct: 192 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGV 251 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 252 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 371 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 372 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 431 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 432 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 486 >sp|A1KKJ8|MURD_MYCBP Tax_Id=410289 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 588 bits (1517), Expect = e-166 Identities = 319/475 (67%), Positives = 348/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 19 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P TP+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 75 GFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 135 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 191 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA GELGV Sbjct: 192 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGV 251 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 252 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 371 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 372 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 431 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 432 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 486 >sp|Q7VEP7|MURD_MYCBO Tax_Id=1765 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 588 bits (1517), Expect = e-166 Identities = 319/475 (67%), Positives = 348/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 19 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P TP+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 75 GFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 135 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 191 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA GELGV Sbjct: 192 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGV 251 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 252 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 371 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 372 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 431 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 432 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 486 >tr|C6DPQ3|C6DPQ3_MYCTK Tax_Id=478434 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis] Length = 489 Score = 588 bits (1517), Expect = e-166 Identities = 319/475 (67%), Positives = 348/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 22 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 77 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P TP+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 78 GFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 137 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 138 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 194 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA GELGV Sbjct: 195 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGV 254 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 255 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 314 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 315 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 374 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 375 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 434 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 435 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 489 >tr|A5WPC7|A5WPC7_MYCTF Tax_Id=336982 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis] Length = 486 Score = 588 bits (1517), Expect = e-166 Identities = 319/475 (67%), Positives = 348/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 19 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P TP+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 75 GFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 135 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 191 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA GELGV Sbjct: 192 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGV 251 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 252 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 371 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 372 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 431 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 432 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 486 >tr|A4KIT3|A4KIT3_MYCTU Tax_Id=395095 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis str. Haarlem] Length = 496 Score = 586 bits (1511), Expect = e-165 Identities = 318/475 (66%), Positives = 347/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 29 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 84 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P P+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 85 GFSPAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 144 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 145 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 201 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA GELGV Sbjct: 202 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGV 261 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 262 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 321 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 322 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 381 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 382 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 441 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 442 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 496 >tr|A2VJQ2|A2VJQ2_MYCTU Tax_Id=348776 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis C] Length = 496 Score = 586 bits (1511), Expect = e-165 Identities = 318/475 (66%), Positives = 347/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 29 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 84 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P P+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 85 GFSPAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 144 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 145 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 201 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA GELGV Sbjct: 202 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGV 261 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 262 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 321 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 322 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 381 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 382 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 441 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 442 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 496 >sp|O06222|MURD_MYCTU Tax_Id=1773 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium tuberculosis] Length = 486 Score = 585 bits (1509), Expect = e-165 Identities = 318/475 (66%), Positives = 347/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 19 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P TP+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 75 GFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 135 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 191 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA ELGV Sbjct: 192 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAARELGV 251 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 252 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 371 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 372 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 431 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 432 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 486 >sp|A5U4I2|MURD_MYCTA Tax_Id=419947 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium tuberculosis] Length = 486 Score = 585 bits (1509), Expect = e-165 Identities = 318/475 (66%), Positives = 347/475 (73%), Gaps = 10/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+AV A LTRFG T+CDDDP L+ +A+ G QQ+ Y LVV SP Sbjct: 19 TGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQI----TGYALVVASP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF+P TP+L AA+AA VPIWGDVELAWRLDAAG YGPPR WLVV SMLHAM Sbjct: 75 GFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAM 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG VLDVL E P++ LAVELSSFQLHWAPSLRPEAG VLNIAED Sbjct: 135 LIAGGRRAVLCGNIGSAVLDVLDE---PAELLAVELSSFQLHWAPSLRPEAGAVLNIAED 191 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH+TMA+YT AKARVLTG VAV GLDDSRAAALL + A VRVGFR GEPA ELGV Sbjct: 192 HLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAARELGV 251 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RD +LVDRAF++DL L+PV SIPV AIADAV FR+G Sbjct: 252 RDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SVLAYPRVVW+AGGLLKGAS+ AEVA MA + Sbjct: 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASR 371 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA---VAVVSGTDVISISDVGG 435 LVGAVLIGRDRA VAEALSRHAP+VPVVQVVAGED GM A V V DV G Sbjct: 372 LVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGE 431 Query: 436 TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 T+G VM R +AQPGDTVLLAPAGASFDQF+GYADRG+ FATAVRA IR Sbjct: 432 TVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR 486 >sp|A0R018|MURD_MYCS2 Tax_Id=246196 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium smegmatis] Length = 493 Score = 516 bits (1328), Expect = e-144 Identities = 287/476 (60%), Positives = 326/476 (68%), Gaps = 13/476 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGRAVL AL +AATLCDD+ AL A G + + Y LVVTSP Sbjct: 25 TGRAVLGALAPLEVAATLCDDNADALAALAAKGVAVIAPGDAIASIGD----YALVVTSP 80 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GFAP+ PVL AA+AA VPIWGDVELAWRLDAAG YGPPRRWLVV SMLH M Sbjct: 81 GFAPSAPVLAAAAAAGVPIWGDVELAWRLDAAGRYGPPRRWLVVTGTNGKTTTTSMLHDM 140 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RRS+LCGNIG PVL VL + P++ LAVELSSFQLHWAPSLRPEAGVVLN+AED Sbjct: 141 LVAGGRRSVLCGNIGDPVLAVLDQ---PAELLAVELSSFQLHWAPSLRPEAGVVLNVAED 197 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH +MA Y KARVL GRVAVVGLDD AA LL T A VRVGFR G+PA GELGV Sbjct: 198 HLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLGDPAAGELGV 257 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RDG L+DRAF + + L I V+ AI A+A F++G Sbjct: 258 RDGKLIDRAFDDGVELADCADIGVAGPIGVLDALGAAALARAVGVAPGAIGAALASFQVG 317 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVV DG+ ++DDSKATNPHAA S+ AY RVVWVAGGLLKGASVD V ++A + Sbjct: 318 RHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVDELVRQVANR 377 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGM----HAVAVVSGTDVISISDVG 434 L GAVLIGRDR MVA+ALSRHAP+VPVV++VAGED+G+ ++ V G V + +VG Sbjct: 378 LAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESV-GDHVTRVIEVG 436 Query: 435 G-TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAI 489 G + VM RDLA PGDTVLLAPAGASFDQFSGY RGD FA AVRAA+ Sbjct: 437 GRPVSDAVMSAVVSAARDLASPGDTVLLAPAGASFDQFSGYGQRGDAFAAAVRAAV 492 >tr|Q1B6W9|Q1B6W9_MYCSS Tax_Id=164756 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 509 bits (1310), Expect = e-142 Identities = 277/475 (58%), Positives = 318/475 (66%), Gaps = 11/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGR+V A L G+ T+CDDDP ALQ+ + Y LVVTSP Sbjct: 23 TGRSVSAVLEPTGVRLTICDDDPLALQRLITPAAVVTTG-----EAVAGIADYALVVTSP 77 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF PT PVL AA+AA VPIWGDVELAWRLD AG++GPPRRWLVV SML+A+ Sbjct: 78 GFPPTAPVLAAAAAAGVPIWGDVELAWRLDRAGWFGPPRRWLVVTGTNGKTTTTSMLYAI 137 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFA-----EPSDFLAVELSSFQLHWAPSLRPEAGVVL 193 L A +RR++LCGNIG PVLDVL E E + LAVELSSFQLHWAPSLRP+AGVVL Sbjct: 138 LRAADRRAMLCGNIGNPVLDVLGESPRTRGDEEPELLAVELSSFQLHWAPSLRPDAGVVL 197 Query: 194 NIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAV 253 N+AEDHLDWH +M Y KAR L GRVAV GLDD AA LL+T APVRVGFR G P Sbjct: 198 NVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVAAELLTTAAAPVRVGFRLGPPGA 257 Query: 254 GELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVA 313 GELGV DG+LVD AFA+ L L I V+ A+A A+A Sbjct: 258 GELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNALAAAALARAVDVPAEAVAAALA 317 Query: 314 LFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVA 373 F +GRHRAEVVAV+ G+ +VDDSKATNPHAA S+ AYPRVVW+AGGLLKG SVDA VA Sbjct: 318 SFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAAYPRVVWIAGGLLKGVSVDALVA 377 Query: 374 RMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDV 433 +A +L G VLIGRDRA+VAEALSRHAP+VPVV++V GED+G+H + V + D Sbjct: 378 EVADRLAGVVLIGRDRAVVAEALSRHAPDVPVVELVTGEDSGVHGTTESAVNHVTRVIDT 437 Query: 434 GG-TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 GG + VM R LA+PGD VLLAPAGASFDQFSGY RGD FA AVRA Sbjct: 438 GGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQFSGYTQRGDAFAAAVRA 492 >tr|A1UI56|A1UI56_MYCSK Tax_Id=189918 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 509 bits (1310), Expect = e-142 Identities = 277/475 (58%), Positives = 318/475 (66%), Gaps = 11/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGR+V A L G+ T+CDDDP ALQ+ + Y LVVTSP Sbjct: 23 TGRSVSAVLEPTGVRLTICDDDPLALQRLITPAAVVTTG-----EAVAGIADYALVVTSP 77 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF PT PVL AA+AA VPIWGDVELAWRLD AG++GPPRRWLVV SML+A+ Sbjct: 78 GFPPTAPVLAAAAAAGVPIWGDVELAWRLDRAGWFGPPRRWLVVTGTNGKTTTTSMLYAI 137 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFA-----EPSDFLAVELSSFQLHWAPSLRPEAGVVL 193 L A +RR++LCGNIG PVLDVL E E + LAVELSSFQLHWAPSLRP+AGVVL Sbjct: 138 LRAADRRAMLCGNIGNPVLDVLGESPRTRGDEEPELLAVELSSFQLHWAPSLRPDAGVVL 197 Query: 194 NIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAV 253 N+AEDHLDWH +M Y KAR L GRVAV GLDD AA LL+T APVRVGFR G P Sbjct: 198 NVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVAAELLTTAAAPVRVGFRLGPPGA 257 Query: 254 GELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVA 313 GELGV DG+LVD AFA+ L L I V+ A+A A+A Sbjct: 258 GELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNALAAAALARAVDVPAEAVAAALA 317 Query: 314 LFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVA 373 F +GRHRAEVVAV+ G+ +VDDSKATNPHAA S+ AYPRVVW+AGGLLKG SVDA VA Sbjct: 318 SFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAAYPRVVWIAGGLLKGVSVDALVA 377 Query: 374 RMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDV 433 +A +L G VLIGRDRA+VAEALSRHAP+VPVV++V GED+G+H + V + D Sbjct: 378 EVADRLAGVVLIGRDRAVVAEALSRHAPDVPVVELVTGEDSGVHGTTESAVNHVTRVIDT 437 Query: 434 GG-TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 GG + VM R LA+PGD VLLAPAGASFDQFSGY RGD FA AVRA Sbjct: 438 GGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQFSGYTQRGDAFAAAVRA 492 >tr|A3Q1M0|A3Q1M0_MYCSJ Tax_Id=164757 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 507 bits (1305), Expect = e-141 Identities = 277/475 (58%), Positives = 317/475 (66%), Gaps = 11/475 (2%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGR+V A L G+ T+CDDDP ALQ+ + Y LVVTSP Sbjct: 23 TGRSVSAVLEPTGVRLTICDDDPLALQRLITPAAVVTTG-----EAVAGIADYALVVTSP 77 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF PT PVL AA+AA VPIWGDVELAWRLD AG++GPPRRWLVV SML+A+ Sbjct: 78 GFPPTAPVLSAAAAAGVPIWGDVELAWRLDRAGWFGPPRRWLVVTGTNGKTTTTSMLYAI 137 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFA-----EPSDFLAVELSSFQLHWAPSLRPEAGVVL 193 L A +RR +LCGNIG PVLDVL E E + LAVELSSFQLHWAPSLRP+AGVVL Sbjct: 138 LRAADRRVMLCGNIGNPVLDVLGESPRTRGDEEPELLAVELSSFQLHWAPSLRPDAGVVL 197 Query: 194 NIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAV 253 N+AEDHLDWH +M Y KAR L GRVAV GLDD AA LL+T APVRVGFR G P Sbjct: 198 NVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVAAELLTTAAAPVRVGFRLGPPGA 257 Query: 254 GELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVA 313 GELGV DG+LVD AFA+ L L I V+ A+A A+A Sbjct: 258 GELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNALAAAALARAVDVPAEAVAAALA 317 Query: 314 LFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVA 373 F +GRHRAEVVAV+ G+ +VDDSKATNPHAA S+ AYPRVVW+AGGLLKG SVDA VA Sbjct: 318 SFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAAYPRVVWIAGGLLKGVSVDALVA 377 Query: 374 RMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDV 433 +A +L G VLIGRDRA+VAEALSRHAP+VPVV++V GED+G+H + V + D Sbjct: 378 EVADRLTGVVLIGRDRAVVAEALSRHAPDVPVVELVTGEDSGVHGTTESAVNHVTRVIDT 437 Query: 434 GG-TIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 GG + VM R LA+PGD VLLAPAGASFDQFSGY RGD FA AVRA Sbjct: 438 GGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQFSGYTQRGDAFAAAVRA 492 >tr|A4TBF3|A4TBF3_MYCGI Tax_Id=350054 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium gilvum] Length = 487 Score = 502 bits (1292), Expect = e-140 Identities = 277/473 (58%), Positives = 319/473 (67%), Gaps = 8/473 (1%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG+A+LAALT G ATL DD P AL +A G ER + LVVTSP Sbjct: 22 TGQAILAALTPLGARATLTDDSPTALTAFAQQGVEVLDPAAAV----ERIAAFDLVVTSP 77 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF PT PVL AA+ A VPIWGDVELAWRLD +G +GPPR+WLVV SMLHAM Sbjct: 78 GFPPTAPVLAAAADAGVPIWGDVELAWRLDRSGRFGPPRQWLVVTGTNGKTTTTSMLHAM 137 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L + RR++LCGNIG PVL +L + P+D AVELSSFQLHWAPSLRPEAG VLN+AED Sbjct: 138 LESAGRRAVLCGNIGDPVLTLLEQ---PADVFAVELSSFQLHWAPSLRPEAGAVLNVAED 194 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH +MA Y KAR LTGRVAV GLDD AA LL + A V+VGFR G P GE GV Sbjct: 195 HLDWHGSMAAYAADKARALTGRVAVGGLDDEIAAGLLGSAPAAVKVGFRLGAPGPGEFGV 254 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RDG L+D AFA+ L L V SIPV+ AIA A+A F++G Sbjct: 255 RDGALIDNAFADGLELAAVDSIPVAGPVGVLNALAAAALARAVDVPAEAIATALAGFQVG 314 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA S+ AYPRVVW+AGG+LKGASV+ V+ A Sbjct: 315 RHRAEVVAVADGITYVDDSKATNPHAARASIDAYPRVVWIAGGMLKGASVEDLVSDSADH 374 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGG-TI 437 LVGAVLIGRDRA+VAEAL+RHAP+VPVV++V GED+G+ T V + ++ Sbjct: 375 LVGAVLIGRDRAVVAEALARHAPDVPVVELVTGEDSGVLEKDESGVTRVTRVVQADSESL 434 Query: 438 GTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 VM R LA PGD +LLAPAGASFDQF+ Y RGDTFA AVRAA+R Sbjct: 435 SDAVMAAAVRAARGLAAPGDAILLAPAGASFDQFTSYGHRGDTFAAAVRAALR 487 >sp|A1TAX0|MURD_MYCVP Tax_Id=350058 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium vanbaalenii] Length = 483 Score = 493 bits (1269), Expect = e-137 Identities = 274/473 (57%), Positives = 312/473 (65%), Gaps = 8/473 (1%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGRAVLAAL G ATL DD P AL A ++ + + LVV SP Sbjct: 18 TGRAVLAALAPLGARATLTDDSPTALTASAQQRVEVLDPATAVDRIAD----FDLVVVSP 73 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 G PT P+ VAA+AA +P+WGDVELAW LD +G +GPPR+WLVV SML+AM Sbjct: 74 GIPPTAPIPVAAAAAGIPVWGDVELAWHLDRSGRFGPPRQWLVVTGTNGKTTTTSMLYAM 133 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A RR++LCGNIG PVL L P+D LAVELSSFQLHWAPSLRPEAG VLN+AED Sbjct: 134 LQAGGRRAVLCGNIGDPVLSQLDR---PADVLAVELSSFQLHWAPSLRPEAGAVLNVAED 190 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH +MA Y KAR LTGRVAV GLDD+ AA LL+ APV+VGFR G+P GE GV Sbjct: 191 HLDWHGSMAAYAGDKARALTGRVAVGGLDDAIAAGLLADAPAPVKVGFRLGDPGPGEFGV 250 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 RDG L+D AF DLAL +IPV+ AIA+A+A F +G Sbjct: 251 RDGVLIDNAFGRDLALADADTIPVAGPVGVLDALAAAALARAVDVPAAAIAEALATFHVG 310 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 RHRAEVVAVADGI YVDDSKATNPHAA SV A+PRVVWVAGGLLKGASVD V + Sbjct: 311 RHRAEVVAVADGITYVDDSKATNPHAAQASVSAFPRVVWVAGGLLKGASVDEMVEATKDR 370 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGG-TI 437 LVG VLIGRDRA+V ALSRHAP+VPVV++V GED+ + T V + G T+ Sbjct: 371 LVGVVLIGRDRAIVGNALSRHAPDVPVVELVTGEDSVVLEKDESGVTRVTRVIQTGDRTL 430 Query: 438 GTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 VM R LA GDTVLLAPAGASFDQF+GY RGD FA AVRAAIR Sbjct: 431 ADAVMTAAVDAARGLATSGDTVLLAPAGASFDQFTGYGHRGDAFAAAVRAAIR 483 >tr|B1MP35|B1MP35_MYCA9 Tax_Id=561007 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium abscessus] Length = 488 Score = 473 bits (1216), Expect = e-131 Identities = 262/473 (55%), Positives = 311/473 (65%), Gaps = 14/473 (2%) Query: 19 TGRAVLAALTRF---GMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVV 75 TG AV+AALT G+ T+CDDD ALQ++ D G + M ++ LV+ Sbjct: 23 TGDAVVAALTGLADLGLRITVCDDDEDALQRHRDAGHGALTTAAAQRHMADQD----LVI 78 Query: 76 TSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSML 135 SPGF P+ PV+ AA A +PIWGDVELAWRLDA+G YG P+RW+VV +M+ Sbjct: 79 VSPGFGPSAPVVQAAVQAGLPIWGDVELAWRLDASGRYGRPKRWVVVTGTNGKTTTTAMV 138 Query: 136 HAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNI 195 H ML A S LCGNIG PVL+VL E FLAVELSSFQLHWAPS+RP AG VLN+ Sbjct: 139 HDMLTAAGGTSALCGNIGDPVLNVLDRDVE---FLAVELSSFQLHWAPSVRPVAGAVLNV 195 Query: 196 AEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGE 255 AEDHLDWH M YT KAR L G VAV GLDD+ A LL+ APV+ GFR GEPAVGE Sbjct: 196 AEDHLDWHGGMEGYTRDKARALDGEVAVAGLDDAIAGGLLAAAAAPVKAGFRAGEPAVGE 255 Query: 256 LGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALF 315 LGV DG+LVDRAF D+ L+ V+ +PV IA A+ +F Sbjct: 256 LGVLDGWLVDRAFGVDIPLIEVSKLPVGGPIGVLNALAAAALARAVGTPAVHIARALEVF 315 Query: 316 RLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARM 375 ++GRHRAE++A + YVDDSKATNPHAA S+ YPRVVW+AGGLLKGA+VD V Sbjct: 316 QVGRHRAELIARVADVAYVDDSKATNPHAAAASIAGYPRVVWIAGGLLKGAAVDDLVRDC 375 Query: 376 APQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGG 435 A +L VLIGRDRA++AEAL+RHAP+VPVV VV EDAG+ VV TD +D GG Sbjct: 376 ADRLGAVVLIGRDRALIAEALARHAPDVPVVAVVTREDAGVQEANVVYVTDE---ADGGG 432 Query: 436 T-IGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 +GTRVM LA+PGDTVLLAPAGASFDQFSGY++RGD FA AV A Sbjct: 433 ADLGTRVMAAAVRHASSLARPGDTVLLAPAGASFDQFSGYSERGDRFAAAVHA 485 >tr|C1AU57|C1AU57_RHOOB Tax_Id=632772 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus opacus] Length = 499 Score = 405 bits (1042), Expect = e-111 Identities = 229/467 (49%), Positives = 278/467 (59%), Gaps = 4/467 (0%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 +GRA + L G T+ D + AL + A G + E+ ++ LVVTSP Sbjct: 24 SGRATIEPLRDLGAHVTVTDSNVDALAECARRGAATVPIDDLLAER-EKVAEFALVVTSP 82 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF P P+L AA+ VPIWGD+E +W +D AG YGPPRRWLVV SML ++ Sbjct: 83 GFRPDAPLLSAAAGDGVPIWGDIEFSWHVDRAGLYGPPRRWLVVTGTNGKTTTTSMLQSI 142 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A SL CGNIG PVLD L ++ LAVELSSFQLHWAPS+RP AG +LNIAED Sbjct: 143 LEAAGLPSLACGNIGLPVLDALRPTGPRAEVLAVELSSFQLHWAPSVRPTAGAILNIAED 202 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH M Y AKAR LTG VAV+GLDD A++L S+++A +GFR G PA GELGV Sbjct: 203 HLDWHGGMQPYIDAKARALTGEVAVLGLDDEVASSLFSSSLAVRTLGFRLGVPAAGELGV 262 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 DGYLVDRAFA+ L P I A+A +A +G Sbjct: 263 EDGYLVDRAFADGERLAPADGITPPGPAGLMDALAAAALARAIGVPPDAVAAGLAAHVVG 322 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 HRA VA G+ +VDDSKATNPHAA S+LA+ RVVW+AGGLLKGA VD V +A + Sbjct: 323 PHRAARVAEVGGVTFVDDSKATNPHAARPSILAHDRVVWIAGGLLKGARVDDLVREVAGR 382 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIG 438 L GAVL+GRD +AE+L+RHAP VPVV V G+DAG+ AV + V+ +D T Sbjct: 383 LAGAVLLGRDARQIAESLARHAPEVPVVTVETGDDAGVSAVPQTATHRVVLAAD---TDS 439 Query: 439 TRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAV 485 VM LA GD V+LAPA AS D F Y RG +FA AV Sbjct: 440 DAVMGVVVREAAALASAGDAVVLAPAAASLDMFDSYGHRGRSFAVAV 486 >sp|Q0SHR9|MURD_RHOSR Tax_Id=101510 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Rhodococcus sp.] Length = 499 Score = 404 bits (1038), Expect = e-110 Identities = 229/467 (49%), Positives = 280/467 (59%), Gaps = 4/467 (0%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 +GRA + L G T+ D + AL + A G + +R ++ LVVTSP Sbjct: 24 SGRATIEPLRDLGALVTVTDANVDALAECARLGAATVPIDDLLAER-DRVAEFALVVTSP 82 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF P P+L A+ VPIWGD+E +W +D AG YGPPRRWLVV SML ++ Sbjct: 83 GFRPDAPLLSLAAGDGVPIWGDIEFSWHVDRAGLYGPPRRWLVVTGTNGKTTTTSMLQSI 142 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A SL CGNIG PVLD L + ++ LAVELSSFQLHWAPS+RP AG +LNIAED Sbjct: 143 LEAAELPSLACGNIGIPVLDALRQTEPRAEALAVELSSFQLHWAPSVRPTAGAILNIAED 202 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH M Y AKAR LTG VAV+GLDD A++L S++ A VGFR G PA GELGV Sbjct: 203 HLDWHGGMQPYIDAKARALTGEVAVLGLDDEVASSLFSSSPAVRTVGFRLGVPAPGELGV 262 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 DGYLVDRAFA+ L P I A+A +A +G Sbjct: 263 EDGYLVDRAFADGERLAPAEGITPPGPAGLMDALAAAALARAIGVPPDAVAAGLAAHVVG 322 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 HRA +VA G+ +VDDSKATNPHAA S+LA+ RVVW+AGGLLKGA VD V +A + Sbjct: 323 PHRAALVAEVGGVTFVDDSKATNPHAARPSILAHERVVWIAGGLLKGARVDDLVREVASR 382 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIG 438 L GAVL+GRD +AE+L+RHAP VPVV V G+DAG+ AV + V+ +D T Sbjct: 383 LAGAVLLGRDAMQIAESLARHAPEVPVVTVETGDDAGVSAVPQTATHRVVLPAD---TDS 439 Query: 439 TRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAV 485 VM LA GD+V+LAPA AS D F+ Y RGD+F AV Sbjct: 440 DAVMGVVVREAAALATAGDSVVLAPAAASLDMFASYGHRGDSFTDAV 486 >tr|C3JJ50|C3JJ50_RHOER Tax_Id=596309 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus erythropolis SK121] Length = 507 Score = 391 bits (1004), Expect = e-106 Identities = 213/469 (45%), Positives = 280/469 (59%), Gaps = 4/469 (0%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 +G+A + L G T+ D ++ A+ G + + +Y LVVTSP Sbjct: 27 SGQATIEPLVALGAVVTVADSTLDFAERCAELGADMVTTTSI-EDAPDSITEYGLVVTSP 85 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF P P+L AA+ +PIWGDVE +WR+D +G++G PR+WLVV SML ++ Sbjct: 86 GFRPDAPILAAAAGHGIPIWGDVEFSWRVDHSGHFGTPRKWLVVTGTNGKTTTTSMLASI 145 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L CGNIG P+LD L E + ++LAVELSSFQLHWAPS+RP+AGVVLN+AED Sbjct: 146 LDGAGVVGRACGNIGLPILDALAETSPRVEYLAVELSSFQLHWAPSVRPDAGVVLNVAED 205 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH M+ Y AK+R L+GRVAVVGLDD+ A+ L + A + GFR GEP GELGV Sbjct: 206 HLDWHGGMSAYAEAKSRALSGRVAVVGLDDAIASELGTRATADIVTGFRLGEPGEGELGV 265 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 G+LVD AF + + L SI + + +A ++G Sbjct: 266 EAGHLVDNAFGDHVRLAEAASIDPAGPAGVMDALAAAALARALGFEADVVERGLAAHKVG 325 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 HR +V + Y+DDSKATNPHAA S+LA+ RVVWVAGGLLKGASVD V+ + P+ Sbjct: 326 PHRGALVGRVGSVVYIDDSKATNPHAARPSILAHDRVVWVAGGLLKGASVDQLVSEVGPR 385 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIG 438 L GAVL+GRD ++ +AL+RHAP+VPVV V++G+DA V+ S ++I G Sbjct: 386 LSGAVLLGRDAGVIEDALARHAPDVPVVHVMSGDDA---VVSENSSNSTLTIRLPSGADA 442 Query: 439 TRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 VM +LA PGD V+LAPA AS D F+ Y RGD+FA AV A Sbjct: 443 DAVMAAVVVEAAELASPGDAVVLAPAAASLDMFASYGHRGDSFAAAVAA 491 >tr|C1A0X7|C1A0X7_RHOE4 Tax_Id=234621 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus erythropolis] Length = 507 Score = 389 bits (999), Expect = e-106 Identities = 212/469 (45%), Positives = 280/469 (59%), Gaps = 4/469 (0%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 +G+A + L G T+ D Q+ A+ G + + +Y LVVTSP Sbjct: 27 SGQATIEPLVALGAVVTVADSTLDFAQRCAELGADMVTTTSI-EDAPDSITEYGLVVTSP 85 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF P P+L AA+ +PIWGDVE +WR+D +G++G PR+WLVV SML ++ Sbjct: 86 GFRPDAPILAAAAGHGIPIWGDVEFSWRVDHSGHFGGPRKWLVVTGTNGKTTTTSMLASI 145 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A CGNIG P+LD L E + ++LAVELSSFQLHWAPS+RP+AGVVLN+AED Sbjct: 146 LDAAGVVGRACGNIGLPILDALAETSPRVEYLAVELSSFQLHWAPSVRPDAGVVLNVAED 205 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH M+ Y AK+R L+G+VAVVGLDD+ A+ L + A + GFR GEP GELGV Sbjct: 206 HLDWHGGMSAYAEAKSRALSGKVAVVGLDDAIASELGTRATADIVTGFRLGEPGEGELGV 265 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 G+LVD AF + + L SI + + +A ++G Sbjct: 266 EAGHLVDNAFGDHVRLAEAASIDPAGPAGVMDALAAAALARALGFEADVVERGLAAHKVG 325 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 HR +V + Y+DDSKATNPHAA S+LA+ RVVWVAGGLLKGASV+ V+ + P+ Sbjct: 326 PHRGALVGRVGSVVYIDDSKATNPHAARPSILAHDRVVWVAGGLLKGASVEQLVSEVGPR 385 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIG 438 L GAVL+GRD ++ +AL+RHAP+VPVV V++G+D AV+ S ++I G Sbjct: 386 LSGAVLLGRDAGVIEDALARHAPDVPVVHVLSGDD---EAVSENSSNSTLTIRLPSGADA 442 Query: 439 TRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 VM +LA PGD V+LAPA AS D F+ Y RGD+F AV A Sbjct: 443 DAVMAAVVVEAAELASPGDAVVLAPAAASLDMFASYGHRGDSFTAAVAA 491 >tr|C2ATS3|C2ATS3_TSUPA Tax_Id=521096 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Tsukamurella paurometabola DSM 20162] Length = 486 Score = 366 bits (940), Expect = 3e-99 Identities = 222/478 (46%), Positives = 272/478 (56%), Gaps = 24/478 (5%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TG AV AL R G A T+ D P A ++ A + G Y LVV +P Sbjct: 19 TGPAVARALLRLGAAVTVADGKPVAREKIA--AEVPEVAVVDLDDLDPAG--YALVVVAP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 GF PT P++VAA A VP+ GDVELAW +D AG +G PR WLVV ML ++ Sbjct: 75 GFRPTAPIVVAAQDAGVPVIGDVELAWWIDRAGAFGAPRDWLVVTGTNGKTTTTQMLESI 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 LA ++ CGNIGRPV+D + + A+P LAVELSSFQLHWAPS+RP AGVVLNIAED Sbjct: 135 LAHAGLPAVACGNIGRPVIDAIADAADPR-VLAVELSSFQLHWAPSVRPRAGVVLNIAED 193 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH +MA YT KAR LTG +AVVGLDD AA L P GF GEPA G+ GV Sbjct: 194 HLDWHGSMAAYTADKARALTGDIAVVGLDDPVAATL------PAATGFTVGEPAPGQYGV 247 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 R G L+D A + +++P + A+ FR+G Sbjct: 248 RAGMLIDGAGS---SIVPAARVSPPGPAGIADALAATALAQAVGVTAAQAGAALTQFRVG 304 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 HRAE VA G+ Y+DDSKATNPHAA S+ A+ RVVWVAGG LKGA +D VAR+A + Sbjct: 305 AHRAEPVATVRGVTYIDDSKATNPHAAQNSIEAHERVVWVAGGQLKGADIDPLVARVASR 364 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVS----GTDVISISDVG 434 L GAVL+G D ++A A++RHAP+VPVV+V +G+D+ + V + GT V V Sbjct: 365 LAGAVLLGVDAELIAAAMARHAPDVPVVRVTSGDDSRVSPVTNDASRSIGTSVAGDVRVS 424 Query: 435 GTIGTRVMXXXXXXXRDLAQPG-----DTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 G VM LA VLLAPA AS D F Y RG+ FATA RA Sbjct: 425 GD-ADAVMTAAVHAAAGLADVAGQSRTPVVLLAPAAASLDMFRSYGHRGEAFATAARA 481 >sp|Q5YYY1|MURD_NOCFA Tax_Id=37329 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Nocardia farcinica] Length = 480 Score = 361 bits (927), Expect = 1e-97 Identities = 213/469 (45%), Positives = 264/469 (56%), Gaps = 16/469 (3%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 +GR+++ L G + D AL + A+ G R + LV+TSP Sbjct: 18 SGRSLVEPLRDIGAHPVVTDSGAKALAEAAELGLEVATSVELESADLSR---FALVITSP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 G+ P +PVLV+A +P+WGDVE AW +D A YGP R+WLVV M HA+ Sbjct: 75 GWRPDSPVLVSAVTEGIPVWGDVEFAWWVDQARIYGPVRKWLVVTGTNGKTTTTQMTHAI 134 Query: 139 LAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAED 198 L A S+ CGNIG P+LD L P LAVELSSFQLHWAPS+RPEAGVVLN+AED Sbjct: 135 LRAAGIASVACGNIGLPILDALRRNPGPQ-VLAVELSSFQLHWAPSVRPEAGVVLNVAED 193 Query: 199 HLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGV 258 HLDWH + Y AKAR L GR+ VVGLDD AAAL + A VGFR G PA GELGV Sbjct: 194 HLDWHGGLDAYAAAKARALVGRIGVVGLDDPVAAALARRSKARRTVGFRVGVPADGELGV 253 Query: 259 RDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLG 318 DG L+DRAF + L V I + + + ++G Sbjct: 254 VDGKLLDRAFTKAAILAEVGDISPPGPAGVADALAAAALTRAIDVAPQFVKEGLQEHKVG 313 Query: 319 RHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQ 378 HRA V G+ ++DDSKATNPHAA S+LA+P VVW+AGG LKGA+V+ V +A + Sbjct: 314 PHRAAFVREVAGVEFIDDSKATNPHAARSSILAHPHVVWIAGGRLKGAAVEDLVEEVADR 373 Query: 379 LVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIG 438 LV AVLIG D ++A AL+RHAP VPVV+V AG+DA V D + + Sbjct: 374 LVAAVLIGVDAPVIAAALARHAPEVPVVEVRAGDDA-------VMADDPLRPDEADA--- 423 Query: 439 TRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRA 487 VM A+ GDTVLLAPA AS D F+ Y RG +FA AV A Sbjct: 424 --VMAAAVRTAAGYARAGDTVLLAPAAASLDMFADYTHRGRSFADAVHA 470 >tr|D0LAT4|D0LAT4_9ACTO Tax_Id=526226 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase;[Gordonia bronchialis DSM 43247] Length = 512 Score = 344 bits (882), Expect = 2e-92 Identities = 200/426 (46%), Positives = 242/426 (56%), Gaps = 17/426 (3%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXX 132 LVV SPGFAPT PV VAA+ VP+WG+VELAWR+D AG GPPR WLVV Sbjct: 82 LVVVSPGFAPTHPVAVAAADGSVPVWGEVELAWRVDRAGILGPPRTWLVVTGTNGKTTTT 141 Query: 133 SMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVV 192 SML ++ A R + CGNIG PVLD + A D L ELSSFQLHWAPS+RP+AGVV Sbjct: 142 SMLADIVVAGGRSGIACGNIGLPVLDAML-MAPRVDVLCAELSSFQLHWAPSVRPDAGVV 200 Query: 193 LNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPA 252 LN+AEDHLDWH Y AK R LTG V+VVGLDD A L RVGF GEP Sbjct: 201 LNVAEDHLDWHGGFDGYAGAKTRALTGAVSVVGLDDEVAGGL---PTQGRRVGFTLGEPG 257 Query: 253 VGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAV 312 +LGV LVDRAF + L+ +I A+ADA+ Sbjct: 258 PDDLGVVGAELVDRAFGSGV-LLAAEAIHPPGPSGLSDALAASALALAAGVDRAAVADAL 316 Query: 313 ALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEV 372 FR HR EVVA + GIR+VDDSKATNPHAA ++ + RVV +AGGLLKGASVD + Sbjct: 317 TAFRPAGHRGEVVAESAGIRFVDDSKATNPHAAQAAIAGFDRVVLIAGGLLKGASVDRMI 376 Query: 373 ARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISD 432 + +L G V IG+DR ++ +A++RHAP VP V V G+D G++ + ++ S + Sbjct: 377 DAVRHRLAGVVAIGQDRDIIVDAIARHAPEVPTVTVFTGDDGGVNVHRMACARNLASARN 436 Query: 433 VGGTI--------GTRVMXXXXXXXRDLAQPGD----TVLLAPAGASFDQFSGYADRGDT 480 + VM LA D VLLAPA AS D F+GY RGD Sbjct: 437 HADPVSPGSPTDPAVAVMDRAVVEAWHLAGAADPTPQAVLLAPAAASLDMFAGYGRRGDA 496 Query: 481 FATAVR 486 FA A R Sbjct: 497 FAAAAR 502 >tr|C8XGY8|C8XGY8_NAKMY Tax_Id=479431 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase;[Nakamurella multipartita] Length = 485 Score = 319 bits (817), Expect = 6e-85 Identities = 192/424 (45%), Positives = 233/424 (54%), Gaps = 39/424 (9%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYG---PPRRWLVVXXXXXXX 129 LV+TS G PT P+LVAA+AA + + G+VELAWR+D G G PR WLVV Sbjct: 75 LVITSAGIPPTNPLLVAAAAAGIEVIGEVELAWRIDHDGPAGGQTAPRPWLVVTGTNGKT 134 Query: 130 XXXSMLHAMLAADNRRSLLCGNIGRPVL--------DVLTEFAEPSDFLAVELSSFQLHW 181 ML ++L A R CGNIG PVL D L + D +AVELSSFQLHW Sbjct: 135 TTTGMLESILRAAGRTVTACGNIGWPVLAAVLAGGRDALDDTPR-QDVIAVELSSFQLHW 193 Query: 182 APSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAP 241 APSLRP AGVVLN+AEDHLDWH +MA Y KAR L G +A+ +DDS AA LL+ AP Sbjct: 194 APSLRPRAGVVLNLAEDHLDWHGSMAAYGADKARALAGEIALAVVDDSGAAGLLAGAGAP 253 Query: 242 VRVGFRFGEPAVGELGVRDGYLVDRAFAEDL-ALMPVTSIPVSXXXXXXXXXXXXXXXXX 300 R+ P G LG+ DG+LVD A+A L ++ Sbjct: 254 RRIPITAAAPVAGRLGLADGWLVDHAYAASAQRLAAAEAVRPPGAHNLTNALAAAGLALA 313 Query: 301 XXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG 360 A+A +A F G HR +V G+RYVDDSKATNPHAAL S+LAYPRVVW+AG Sbjct: 314 AGVPAQAVATGLAAFAPGGHRNVLVTQRAGVRYVDDSKATNPHAALASLLAYPRVVWIAG 373 Query: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420 G LKGA VD V + +L G VL+G D ++ A+SRHAP+VPV+ V +D M +V Sbjct: 374 GQLKGAQVDELVLAVRDRLAGVVLLGVDAPVIHAAVSRHAPDVPVLPVPGTDDDVMRSVV 433 Query: 421 VVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480 + +A PGD VLLAPA AS D FS YA RG Sbjct: 434 CAAAR--------------------------MAAPGDVVLLAPAAASLDMFSSYAARGQA 467 Query: 481 FATA 484 FA A Sbjct: 468 FAAA 471 >tr|C6WDE4|C6WDE4_ACTMD Tax_Id=446462 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; Flags: Precursor;[Actinosynnema mirum] Length = 450 Score = 318 bits (814), Expect = 1e-84 Identities = 189/414 (45%), Positives = 232/414 (56%), Gaps = 34/414 (8%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXX 132 LVVTSPG+ P P+L A++AA V + G+VELAWR+ A P WLVV Sbjct: 67 LVVTSPGWRPDNPLLAASAAAGVEVIGEVELAWRM--AAELADPPAWLVVTGTNGKTTTV 124 Query: 133 SMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVV 192 +ML ++L A ++ CGN+G PV+D L LAVELSSFQLHW+PS+RP AGV+ Sbjct: 125 TMLESILRAAGLDAIACGNVGLPVVDALLAGHR---VLAVELSSFQLHWSPSVRPTAGVL 181 Query: 193 LNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPA 252 LN+AEDHLDWH ++ Y AKA L G VA+ G+DD AALL+ + VG GEP Sbjct: 182 LNVAEDHLDWHGSLEAYARAKAGALVGDVAIAGVDDPYVAALLTGSPGTAHVGITLGEPE 241 Query: 253 VGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAV 312 G+LGV GYLVDRAF D L V + A+ + Sbjct: 242 EGQLGVAGGYLVDRAFGPDSRLAAVADVTPGGPPGIADALAAAALARAYGVAPEAVRQGL 301 Query: 313 ALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEV 372 FR G HR VV G+RYV+DSKATNPHAA+ S+ ++ VVW+AGGLLKGASV V Sbjct: 302 LDFRPGDHRGVVVGEVGGVRYVNDSKATNPHAAVASLRSHESVVWIAGGLLKGASVADLV 361 Query: 373 ARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISD 432 A +L AVLIG DRA +A AL+ HAP VPVV++ G AG AV +G Sbjct: 362 RAEAHRLRAAVLIGADRAAIAAALAEHAPAVPVVELAEGGMAG--AVRAAAG-------- 411 Query: 433 VGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVR 486 A+PGD VLLAPA AS D F+ YA RG FA AVR Sbjct: 412 -------------------FARPGDAVLLAPAAASMDMFADYAHRGRAFAEAVR 446 >tr|A4FLW2|A4FLW2_SACEN Tax_Id=405948 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Saccharopolyspora erythraea] Length = 469 Score = 305 bits (781), Expect = 9e-81 Identities = 185/426 (43%), Positives = 235/426 (55%), Gaps = 41/426 (9%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLD---------AAGYYGPPRRWLVVX 123 LVVTSPG+ P +P+L A AA V + G+VELAWRLD + G P WL V Sbjct: 60 LVVTSPGWRPESPLLAATVAAGVELIGEVELAWRLDQEKANEPADSTGRPAGPATWLAVT 119 Query: 124 XXXXXXXXXSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAP 183 ML ++L AD + CGN+G PV+D + LAVELSSFQLHW+ Sbjct: 120 GTNGKTTTVGMLESILRADGVDVVACGNVGLPVVDAVRAGHR---VLAVELSSFQLHWSQ 176 Query: 184 SLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPV- 242 ++ P A VVLN+A DHLDWH ++ Y AKARV G V D + L+ AP Sbjct: 177 TVAPHASVVLNLAADHLDWHGSLDAYGAAKARVYAGNSVAVHNADDEWSVRLADAGAPQQ 236 Query: 243 --RVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXX 300 RV F +PA G LGV G LVDRAF + + L V + + Sbjct: 237 ARRVSFTLSDPAPGVLGVESGALVDRAFGDRVRLAAVADVHPAGPHNVANALAAASLARA 296 Query: 301 XXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG 360 A+A+ + F+ G HR+ VVA + G+ YVDDSKATNPHAA ++ A+P+VVW+AG Sbjct: 297 YGVEPEAVAEGLRSFQPGAHRSVVVAESAGVSYVDDSKATNPHAADAALRAHPKVVWIAG 356 Query: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420 GLLKGA V+ VA A +L G VLIGRDRA AEAL+RHAP+VPV +V +G+DAGM A Sbjct: 357 GLLKGADVEDLVAANAARLAGVVLIGRDRARFAEALARHAPDVPVREVESGDDAGMLAAV 416 Query: 421 VVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480 ++G + A+PG V+LAPA AS D F+ YA RG Sbjct: 417 RLAG--------------------------EFAEPGCAVVLAPAAASMDMFTDYAHRGRA 450 Query: 481 FATAVR 486 FA AVR Sbjct: 451 FADAVR 456 >sp|Q8FNT8|MURD_COREF Tax_Id=152794 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Corynebacterium efficiens] Length = 475 Score = 296 bits (759), Expect = 3e-78 Identities = 171/419 (40%), Positives = 226/419 (53%), Gaps = 26/419 (6%) Query: 71 YVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXX 130 Y +VVTSPG+ P +PVLV A++ + + GDVELAWRLD AG +G R WL V Sbjct: 77 YSIVVTSPGWRPDSPVLVDAASRGLEVIGDVELAWRLDRAGVFGVSRTWLAVTGTNGKTT 136 Query: 131 XXSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAG 190 +ML AM+ ++ GNIG PV LT + D + ELSSFQLHWAP+L P+AG Sbjct: 137 TTAMLAAMMKQGGFNAVAVGNIGVPVSAALTS-CDRVDVMVAELSSFQLHWAPTLVPDAG 195 Query: 191 VVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGE 250 +VLN+AEDH+DWH + DY +AK RVLT VAV+G DDS L + +GF GE Sbjct: 196 LVLNLAEDHIDWHGSFRDYALAKTRVLTAPVAVIGADDSYLVELTTELGLSGLIGFTLGE 255 Query: 251 PAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIAD 310 P +LGV +G+LVD AFA L L P I S IA Sbjct: 256 PGPRQLGVLNGHLVDNAFAAQLPLAPADGINPSGPAGVLDALAAAAVARSQGVSAEDIAG 315 Query: 311 AVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDA 370 A+A F + HR +VVA G++++D+SKATNPHAA ++ V+W+ GG LKGA + Sbjct: 316 ALATFEVSGHRGQVVAEDHGVQFIDNSKATNPHAADTALAGRESVIWIVGGQLKGADISE 375 Query: 371 EVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISI 430 VA A ++ A+++G DRA + A+ +HAP+ + V TD ++ Sbjct: 376 LVATHAHRIKAALVLGADRAEIVTAVEQHAPDA--------------MIRVTDSTDPVA- 420 Query: 431 SDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAI 489 M A+PGD VLLAPA AS D + G RGD FA AV + I Sbjct: 421 ----------AMRELVDHAFRFAEPGDCVLLAPAAASLDMYKGMGQRGDIFAEAVLSTI 469 >tr|C8NQ14|C8NQ14_COREF Tax_Id=196164 (murD)SubName: Full=UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium efficiens YS-314] Length = 475 Score = 296 bits (759), Expect = 3e-78 Identities = 171/419 (40%), Positives = 226/419 (53%), Gaps = 26/419 (6%) Query: 71 YVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXX 130 Y +VVTSPG+ P +PVLV A++ + + GDVELAWRLD AG +G R WL V Sbjct: 77 YSIVVTSPGWRPDSPVLVDAASRGLEVIGDVELAWRLDRAGVFGVSRTWLAVTGTNGKTT 136 Query: 131 XXSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAG 190 +ML AM+ ++ GNIG PV LT + D + ELSSFQLHWAP+L P+AG Sbjct: 137 TTAMLAAMMKQGGFNAVAVGNIGVPVSAALTS-CDRVDVMVAELSSFQLHWAPTLVPDAG 195 Query: 191 VVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGE 250 +VLN+AEDH+DWH + DY +AK RVLT VAV+G DDS L + +GF GE Sbjct: 196 LVLNLAEDHIDWHGSFRDYALAKTRVLTAPVAVIGADDSYLVELTTELGLSGLIGFTLGE 255 Query: 251 PAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIAD 310 P +LGV +G+LVD AFA L L P I S IA Sbjct: 256 PGPRQLGVLNGHLVDNAFAAQLPLAPADGINPSGPAGVLDALAAAAVARSQGVSAEDIAG 315 Query: 311 AVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDA 370 A+A F + HR +VVA G++++D+SKATNPHAA ++ V+W+ GG LKGA + Sbjct: 316 ALATFEVSGHRGQVVAEDHGVQFIDNSKATNPHAADTALAGRESVIWIVGGQLKGADISE 375 Query: 371 EVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISI 430 VA A ++ A+++G DRA + A+ +HAP+ + V TD ++ Sbjct: 376 LVATHAHRIKAALVLGADRAEIVTAVEQHAPDA--------------MIRVTDSTDPVA- 420 Query: 431 SDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAI 489 M A+PGD VLLAPA AS D + G RGD FA AV + I Sbjct: 421 ----------AMRELVDHAFRFAEPGDCVLLAPAAASLDMYKGMGQRGDIFAEAVLSTI 469 >tr|C7MV95|C7MV95_SACVD Tax_Id=471857 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Saccharomonospora viridis] Length = 458 Score = 291 bits (746), Expect = 1e-76 Identities = 193/476 (40%), Positives = 245/476 (51%), Gaps = 47/476 (9%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 TGR+V AL G T+ D + L + D G G + LVVTSP Sbjct: 16 TGRSVATALVGMGAQVTVTDANAERLAELGDLGVRLVPGLDTPPD----GTR--LVVTSP 69 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGP-PRRWLVVXXXXXXXXXXSMLHA 137 G+ PT P+L AA+++ + + GDVELAWR+ G P P WL V M + Sbjct: 70 GWRPTAPLLTAAASSGIEVIGDVELAWRI---GQERPNPPTWLAVTGTNGKTTTVGMAES 126 Query: 138 MLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAE 197 ML + ++ CGN+G VLD + L VELSSFQLHW+ SL P A VVLN+AE Sbjct: 127 MLRSAGVDAVACGNVGFAVLDAVLA---GHSTLVVELSSFQLHWSRSLAPSASVVLNVAE 183 Query: 198 DHLDWHSTMADYTMAKARVLTGRVAVVG-LDDSRAAALLSTTVAPV--RVGFRFGEPAVG 254 DHLDWH +A+Y K + G VV L D + L P RVGF P G Sbjct: 184 DHLDWHGGLAEYAADKGTIHRGSGTVVANLRDPWSRKLAEEHAPPEARRVGFTLDTPRPG 243 Query: 255 ELGVRDGYLVDRAFAEDLA-----LMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIA 309 ELGV + LVDRAF D L + + A+A Sbjct: 244 ELGVVEDLLVDRAFVADPVHAAEELGTLADVRPGGPHNVANALAAAALVRAYGVGPEAVA 303 Query: 310 DAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVD 369 + + FR G HRA V DG+RY+DDSKATNPHAA+ S+LA+P VVW+AGG LKGASVD Sbjct: 304 EGLRSFRPGAHRAVEVGEFDGVRYIDDSKATNPHAAIGSLLAHPSVVWIAGGQLKGASVD 363 Query: 370 AEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVIS 429 VA +A +L G VL+G D + AEAL+RHAP+V V ++ +G+D M A + Sbjct: 364 ELVAAVAERLRGVVLLGADADVFAEALARHAPDVLVRRIGSGDDEPMTAAVKAA------ 417 Query: 430 ISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAV 485 R+LA+PGD VLLAPA AS D F YA+RG+ FA AV Sbjct: 418 --------------------RELARPGDAVLLAPAAASLDMFRDYAERGEAFAAAV 453 >tr|C0WK95|C0WK95_9CORY Tax_Id=525260 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium accolens ATCC 49725] Length = 465 Score = 288 bits (737), Expect = 1e-75 Identities = 194/478 (40%), Positives = 245/478 (51%), Gaps = 40/478 (8%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 +GR +A L R G+ T+ D + AAL A+ +Y LVVTSP Sbjct: 20 SGRGCVAMLARLGVDTTVADSNAAALAALAEEFGVATVSTDAPAP-----GEYDLVVTSP 74 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 G+ P + +L + AA V + GDVELA+RLD A +GPPR WLVV ML + Sbjct: 75 GWRPDSALLDSFQAAGVEVIGDVELAYRLDRAEVFGPPRTWLVVTGTNGKTTTTGMLTKI 134 Query: 139 LAADNRRSLL----CGNIGRPVLDVLTEFAEPS-DFLAVELSSFQLHWAPSLRPEAGVVL 193 + AD RS L GNIG + D LT A P D L ELSSFQLHW+ LRP+ GV+L Sbjct: 135 MQADTARSGLRAQAVGNIGVSLFDALT--ASPRVDILCAELSSFQLHWSNELRPDVGVLL 192 Query: 194 NIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAV 253 N+AEDHLDWH + Y AKA+ L G AVVG DD+ AA + + V GF GEPA Sbjct: 193 NVAEDHLDWHGSFDAYASAKAKALRGTRAVVGKDDA-AAGRYAAGIDGV-YGFTAGEPAT 250 Query: 254 GELGVRDGYLVDRAFAED-LALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAV 312 GE+GV G LV R ED + L I + AI + + Sbjct: 251 GEVGVSAGRLVSRLDGEDAIDLASAEGIEPAGLAGVLDAAAAASVARLAGASPAAIQEGL 310 Query: 313 ALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEV 372 A + + HR VV G+ Y+D+SKATNPHAA ++ + VVWVAGG LKGA VD + Sbjct: 311 AAYAVAGHRGAVVHEHGGVAYIDNSKATNPHAADAALEGFNSVVWVAGGQLKGADVDELI 370 Query: 373 ARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISISD 432 A A +L AVL+G D++++AEAL+R AP PV + ED A Sbjct: 371 ATHAARLKAAVLVGIDKSIIAEALARRAPQTPVELI---EDTDPQA-------------- 413 Query: 433 VGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 M A+ GDTVLLAPA AS D ++G A RGD FA A R R Sbjct: 414 --------AMNAAVGAAEQHAEAGDTVLLAPAAASLDMYTGMAQRGDLFAAAARDIAR 463 >tr|C6RAX1|C6RAX1_9CORY Tax_Id=553206 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium tuberculostearicum SK141] Length = 463 Score = 287 bits (734), Expect = 2e-75 Identities = 190/479 (39%), Positives = 243/479 (50%), Gaps = 43/479 (8%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADN-GXXXXXXXXXXQQMFERGRKYVLVVTS 77 +GR +A L G+ T+ D + AL + A+ G Q F+ LVVTS Sbjct: 20 SGRGCVAMLASLGVDTTVADSNETALAELAEEFGVATVSVDSAAQGDFD------LVVTS 73 Query: 78 PGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHA 137 PG+ P +P+LVA A V + GDVELA+RLD AG +G PR WLVV ML Sbjct: 74 PGWRPDSPLLVAFQDAGVEVIGDVELAYRLDRAGVFGAPRTWLVVTGTNGKTTTTGMLAQ 133 Query: 138 MLAAD----NRRSLLCGNIGRPVLDVLTEFAEPS-DFLAVELSSFQLHWAPSLRPEAGVV 192 ++ AD +R+L GNIG + D LT A P D L ELSSFQLHW+ LRP+ GV+ Sbjct: 134 IMQADAKRTGKRALAVGNIGVSLFDALT--ATPRVDVLCAELSSFQLHWSSHLRPDVGVL 191 Query: 193 LNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPA 252 LN+A+DHLDWH + Y AKA+VL+G VAVVG DD+ A + T GF EP Sbjct: 192 LNLADDHLDWHGSFDAYARAKAKVLSGDVAVVGKDDAEAVRYAADTTD--FYGFTAAEPT 249 Query: 253 VGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAV 312 GE+GV G LV R + L I + +IA + Sbjct: 250 QGEVGVSAGRLVSRLNEQREDLASAEGIEPAGLAGVLDAAAAASVARLAGATPESIAQGL 309 Query: 313 ALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEV 372 A + + HR VV GI ++D+SKATNPHAA ++ V+W+AGG LKGA VD V Sbjct: 310 AAYTVAGHRGAVVHEHSGITFIDNSKATNPHAADAALKGLNSVIWIAGGQLKGAEVDGLV 369 Query: 373 ARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGED-AGMHAVAVVSGTDVISIS 431 A+ A + AV++G DR VA AL+ HAP+ PV + E A MHA + Sbjct: 370 AKHAAHIKAAVVLGVDREEVARALAAHAPHAPVDVIETQEPFAAMHAAVEAA-------- 421 Query: 432 DVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 A GDTVLLAPA AS D ++G A RGD FA A R R Sbjct: 422 ------------------LQHADAGDTVLLAPAAASLDMYTGMAQRGDVFAAAARELTR 462 >sp|Q47QX1|MURD_THEFY Tax_Id=269800 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Thermobifida fusca] Length = 465 Score = 286 bits (733), Expect = 3e-75 Identities = 180/424 (42%), Positives = 219/424 (51%), Gaps = 40/424 (9%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXX 132 LVVTSPG+ P PVLVAA+ A V + GDVELAWRL AG WL V Sbjct: 70 LVVTSPGWRPDAPVLVAAADAGVEVIGDVELAWRLRPAGQV-----WLAVTGTNGKTTTV 124 Query: 133 SMLHAMLAADNRRSLLCGNIGRPVLDV-LTEFAEPSDFLAVELSSFQLHWAPSLRPEAGV 191 ML AML AD RR+L GN+G PV+D L + + D LAVELSSFQLHW+ +++P A Sbjct: 125 RMLEAMLRADGRRALAVGNVGTPVIDAALADGPDRWDILAVELSSFQLHWSATVQPHAAA 184 Query: 192 VLNIAEDHLDWHSTMADYTMAKARVL-TGRVAVVGLDDSRAAALLSTTVAPVR--VGFRF 248 ++N+A DHLDWH M Y AKA+V G + +V D L T P VGF Sbjct: 185 IINLAPDHLDWHGGMEPYAAAKAKVYGAGTIRIVNAADPALRELAETHGDPAAPLVGFSL 244 Query: 249 GEPAVGELGVRDGYLVDRAFA-----EDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXX 303 P GELG+ + LVDRAF E L + + Sbjct: 245 DVPRAGELGLVEDLLVDRAFVANPRTEATELATLADVTPRAPHNVANALAAAALARSIGV 304 Query: 304 XXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLL 363 A+ + F+ HR VA DG+ YVDDSKATN HAA S+ AYP VVW+AGGLL Sbjct: 305 APEAVRTGLRNFQPEPHRIAHVATIDGVDYVDDSKATNAHAAAASLAAYPSVVWIAGGLL 364 Query: 364 KGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVS 423 KGA V V + A +L G VL+G DR + EAL HAP+VPVV V ++ M V + Sbjct: 365 KGADVTGLVRQAASRLRGVVLLGADRHQLREALDTHAPHVPVVDVARTDEGAMAEVVAAA 424 Query: 424 GTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFAT 483 LAQ GDTVLLAPA AS D F+ Y +RG+ FA Sbjct: 425 AR--------------------------LAQKGDTVLLAPAAASMDMFTNYIERGEAFAR 458 Query: 484 AVRA 487 VRA Sbjct: 459 EVRA 462 >tr|A4QFM5|A4QFM5_CORGB Tax_Id=340322 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium glutamicum] Length = 472 Score = 285 bits (730), Expect = 7e-75 Identities = 169/428 (39%), Positives = 224/428 (52%), Gaps = 26/428 (6%) Query: 63 QMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVV 122 Q E+ + +VVTSPG+ PT+ +LV A + + GDVELAWRLD AG +G P WL V Sbjct: 64 QAQEQLDSFSIVVTSPGWRPTSTLLVDAHRQGLEVIGDVELAWRLDQAGVFGEPHTWLAV 123 Query: 123 XXXXXXXXXXSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWA 182 SML AM+ + GNIG PV + L D L ELSSFQLHW+ Sbjct: 124 TGTNGKTTTTSMLAAMMNEGGFAAKAVGNIGIPVSEALVA-KNRIDVLVAELSSFQLHWS 182 Query: 183 PSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPV 242 P+ P+AGVVLN+AEDH+DWH +M DY +AK VL G+VA++G DD L S Sbjct: 183 PTFTPDAGVVLNLAEDHIDWHGSMRDYALAKMEVLKGKVAIIGADDPYLVQLTSEADLSG 242 Query: 243 RVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXX 302 +GF EPA G+LGV+ G LVD A+ ++ L I + Sbjct: 243 LIGFTVNEPATGQLGVKAGELVDNAYGNNVVLASADGINPAGPAGVLDALAAAAVARSQG 302 Query: 303 XXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGL 362 AIA A+ F + HR +VVA DG+ ++D+SKATNPHAA ++ + V+WV GG Sbjct: 303 VAPEAIARALDSFEVAGHRGQVVAEHDGVHFIDNSKATNPHAADSALAGHDSVIWVVGGQ 362 Query: 363 LKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVV 422 LKGA + V + ++ A+++G DRA + AL HAP V V + A+ + Sbjct: 363 LKGADIAPLVKKHEQRIKAALVLGADRAEIVAALKEHAPQASV--FVTDKTEPFEAMEEI 420 Query: 423 SGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFA 482 T+ SIS +PGDTVLLAPA AS D F G RGD FA Sbjct: 421 V-TEAFSIS----------------------EPGDTVLLAPAAASLDMFKGMGQRGDLFA 457 Query: 483 TAVRAAIR 490 + I+ Sbjct: 458 HNIIGTIK 465 >tr|A1SL82|A1SL82_NOCSJ Tax_Id=196162 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Nocardioides sp.] Length = 488 Score = 285 bits (730), Expect = 7e-75 Identities = 183/433 (42%), Positives = 231/433 (53%), Gaps = 47/433 (10%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXX 132 L+VTSPG+ P+ P+L A A R+PIWG+VELAWRL + P WL V Sbjct: 81 LLVTSPGWKPSAPLLAQARARRIPIWGEVELAWRLRDPDHRTP---WLCVTGTNGKTTTV 137 Query: 133 SMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVV 192 ML ++L A RS+ GN+G P+++ + + EP D LAVELSSFQLH+ S+ EA V Sbjct: 138 QMLDSILRAAGLRSIAVGNVGLPIVEAVMD-PEPYDVLAVELSSFQLHYTDSMSAEAAAV 196 Query: 193 LNIAEDHLDWHSTMADYTMAKARVL--TGRVAVVGLDDSRAAALL--STTVAPVR-VGFR 247 LN+AEDHLDW+S+ Y K R+ + V + D L+ + V R VGF Sbjct: 197 LNVAEDHLDWYSSFGAYAADKGRIYERAQKACVYNVADPETERLVREADVVEGARAVGFT 256 Query: 248 FGEPAVGELGVRDGYLVDRAFAE-------------DLAL-MPVTSIPVSXXXXXXXXXX 293 G P VG +G+ + L DRAF E DLAL P + P + Sbjct: 257 LGMPGVGMVGLVEDILADRAFIEQRDTSAAELCTISDLALHSPGGAAPHNIANALAAAAL 316 Query: 294 XXXXXXXXXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYP 353 A+ D + FR RHR VV A G+ +VDDSKATNPHAA S+LAY Sbjct: 317 ARAHGVSQG----AVRDGLRAFRPDRHRIAVVGAAGGVTWVDDSKATNPHAAQSSLLAYE 372 Query: 354 RVVWVAGGLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGED 413 VVW+AGGL KGA D V + +L G VL+GRDR ++A ALSRHAP+VPV+ V E Sbjct: 373 PVVWIAGGLAKGAHFDDLVRAVRDRLRGVVLLGRDRDVIAGALSRHAPDVPVIVVEDDET 432 Query: 414 AGMHAVAVVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSG 473 G H G R M +LA+PGDTVLLAP AS D F+ Sbjct: 433 EGDH--------------------GGRAMERVVGAAAELARPGDTVLLAPGCASMDMFTN 472 Query: 474 YADRGDTFATAVR 486 YA+RGD FA AVR Sbjct: 473 YAERGDAFADAVR 485 >tr|A3TJS4|A3TJS4_9MICO Tax_Id=313589 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Janibacter sp. HTCC2649] Length = 502 Score = 285 bits (730), Expect = 7e-75 Identities = 182/427 (42%), Positives = 223/427 (52%), Gaps = 44/427 (10%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXX 132 LVVTSPG+APT P+L AA+ A V IWG+VELAWR+ P WL V Sbjct: 98 LVVTSPGWAPTQPLLAAATQAGVAIWGEVELAWRMRPLEGAAP---WLTVTGTNGKTTTV 154 Query: 133 SMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVV 192 ML ++L A +R++ GN+G P+L+ + + EP D +AVELSSFQLHW+ S+RP+A V Sbjct: 155 QMLTSILRAAGKRAISAGNVGTPILEAIMD-PEPFDAIAVELSSFQLHWSDSIRPQASVC 213 Query: 193 LNIAEDHLDWHSTMADYTMAKARVL--TGRVAVVGLDDSRAAALLSTTVAPV---RVGFR 247 LN+A DH+DWH + DY AK +V T + +DD + L+ VGF Sbjct: 214 LNVAPDHVDWHGSYEDYLAAKGKVYNNTQVACIYNVDDPQTERLVEDAEVQEGCRAVGFT 273 Query: 248 FGEPAVGELGVRDGYLVDRAFAEDL--ALMPVTSI-------PVSXXXXXXXXXXXXXXX 298 G PA LG+ L DRAF E A + +I P Sbjct: 274 LGTPAPSMLGLVGEVLADRAFVEQRRHAAAELATIDDLRGDSPDVAPHLVANALAAAALA 333 Query: 299 XXXXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWV 358 A+ + FR HR VA + +RYVDDSKATNPHAA S+ AY VVW+ Sbjct: 334 RAHGVEAGAVRAGLKAFRPEAHRIAHVATLEDVRYVDDSKATNPHAAAASLTAYEHVVWI 393 Query: 359 AGGLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA 418 AGGLLKGA VD V AP L G VLIGRDRA +A+AL+RHAP+VPVV Sbjct: 394 AGGLLKGADVDDLVRTAAPSLRGVVLIGRDRAQIADALARHAPDVPVVD----------- 442 Query: 419 VAVVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRG 478 V+ TD T VM LAQ GD VLLAPA AS D F Y RG Sbjct: 443 ---VADTD------------TGVMDRVVSQAASLAQSGDVVLLAPAAASMDMFVNYGARG 487 Query: 479 DTFATAV 485 D FA AV Sbjct: 488 DAFAEAV 494 >sp|Q9S2W9|MURD_STRCO Tax_Id=1902 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Streptomyces coelicolor] Length = 471 Score = 283 bits (723), Expect = 5e-74 Identities = 182/425 (42%), Positives = 218/425 (51%), Gaps = 40/425 (9%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYG-PPRRWLVVXXXXXXXXX 131 L+VT+PG+ PT P+ AA A VP+WGDVELAWRL G G P WL V Sbjct: 72 LIVTAPGWKPTKPLFTAAGQAGVPVWGDVELAWRL--RGLNGRKPAPWLAVTGTNGKTTT 129 Query: 132 XSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGV 191 ML ++L A R+ GNIG +LD +T E D LAVELSS+QLHWAPSLR + Sbjct: 130 VQMLASILKAAGLRTAAVGNIGVSLLDAVTGEQE-YDVLAVELSSYQLHWAPSLRAHSAA 188 Query: 192 VLNIAEDHLDWHSTMADYTMAKARVLTGR--VAVVGLDDSRAAALLSTTVAPV---RVGF 246 VLN+A DHLDWH +M Y K R+ G V + D L+ +GF Sbjct: 189 VLNLAPDHLDWHGSMEAYAADKGRIYEGNHVACVYNVADKATEDLVRAADVEEGCRAIGF 248 Query: 247 RFGEPAVGELGVRDGYLVDRAFAEDLA-----LMPVTSIPVSXXXXXXXXXXXXXXXXXX 301 G P +LGV +G LVDRAF ED L V+ + Sbjct: 249 TLGTPGPSQLGVVEGLLVDRAFVEDRQKNAQELAEVSDVNPPAPHNIANALAAAGLARAF 308 Query: 302 XXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGG 361 A+ D + F HR VA DG+ YVDDSKATN HA S+ AY +VW+AGG Sbjct: 309 GVSAAAVRDGLRAFTPDAHRIAHVADVDGVAYVDDSKATNTHATEASLAAYESIVWIAGG 368 Query: 362 LLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAV 421 L KGA+ D VA A +L GAVLIG DRA++ EAL+RHAP VPVV + Sbjct: 369 LAKGATFDELVAGAAKRLRGAVLIGADRALIREALARHAPEVPVVDL------------- 415 Query: 422 VSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTF 481 TD T M R LA+PGDTVLLAPA AS D F+ Y RGD F Sbjct: 416 -DRTD------------TGAMLQAVQEARRLARPGDTVLLAPACASMDMFTNYNQRGDAF 462 Query: 482 ATAVR 486 A AVR Sbjct: 463 AQAVR 467 >sp|Q82AD8|MURD_STRAW Tax_Id=33903 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Streptomyces avermitilis] Length = 467 Score = 283 bits (723), Expect = 5e-74 Identities = 189/426 (44%), Positives = 222/426 (52%), Gaps = 45/426 (10%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXX 132 L+VT+PG+ P P+ AA+ A VP+WGDVELAWRL G WL V Sbjct: 71 LIVTTPGWQPDKPLFAAAAEAGVPVWGDVELAWRLRGPG----SAPWLAVTGTNGKTTTV 126 Query: 133 SMLHAMLAADNRRSLLCGNIGRPVLD-VLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGV 191 ML ++L A R+ GNIG +LD VL E E D LAVELSS+QLHWAPSLR + Sbjct: 127 QMLASILTAAGLRTAAVGNIGVSLLDAVLGE--ETYDVLAVELSSYQLHWAPSLRAHSAT 184 Query: 192 VLNIAEDHLDWHSTMADYTMAKARVLTG-RVAVVGLDDSRAAALLSTTVAPVR-----VG 245 VLNIA DHLDWH +M YT K R+ G RVA V +A L A V VG Sbjct: 185 VLNIAPDHLDWHGSMEAYTADKGRIYEGNRVACVYNVADKATEDL-VRAADVEEGCRAVG 243 Query: 246 FRFGEPAVGELGVRDGYLVDRAFAEDLA-----LMPVTSIPVSXXXXXXXXXXXXXXXXX 300 F G P +LGV +G LVDRAF ED L V + Sbjct: 244 FTLGTPGPSQLGVVEGILVDRAFVEDRQKNAQELAEVADVHPPAPHNIANALAAAALARA 303 Query: 301 XXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAG 360 +A+ D + FR HR VA DG+ Y+DDSKATN HAA S+ AY +VW+AG Sbjct: 304 FGVPASAVRDGLRAFRPDAHRIAHVADVDGVTYIDDSKATNTHAAEASLAAYGSIVWIAG 363 Query: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420 GL KGAS D VA+ A +L G VLIG DRA++ EAL+RHAP VPVV Sbjct: 364 GLAKGASFDELVAKSAQRLRGVVLIGADRALIREALARHAPEVPVVD------------- 410 Query: 421 VVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480 + TD T M R LA GDTVLLAPA AS D F+ Y RGD Sbjct: 411 -LDRTD------------TGAMPAAVQEARRLAVAGDTVLLAPACASMDMFANYNKRGDA 457 Query: 481 FATAVR 486 FA AVR Sbjct: 458 FAEAVR 463 >tr|Q6M3S0|Q6M3S0_CORGL Tax_Id=1718 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium glutamicum] Length = 472 Score = 282 bits (722), Expect = 6e-74 Identities = 168/428 (39%), Positives = 223/428 (52%), Gaps = 26/428 (6%) Query: 63 QMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVV 122 Q E+ + +VVTSPG+ PT+ +LV A + + GDVELAWRLD AG +G P WL V Sbjct: 64 QAQEQLDSFSIVVTSPGWRPTSTLLVDAHRQGLEVIGDVELAWRLDQAGVFGEPHTWLAV 123 Query: 123 XXXXXXXXXXSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWA 182 SML AM+ + GNIG PV + L D L ELSSFQLHW+ Sbjct: 124 TGTNGKTTTTSMLAAMMNEGGFTAKAVGNIGIPVSEALVA-KNRIDVLVAELSSFQLHWS 182 Query: 183 PSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPV 242 P+ P+AGVVLN+AEDH+DWH +M DY +AK VL G+VA++G DD L S Sbjct: 183 PTFTPDAGVVLNLAEDHIDWHGSMRDYALAKMEVLKGKVAIIGADDPYLVQLTSEADLSG 242 Query: 243 RVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXX 302 +GF EPA G+LGV+ G LVD A+ ++ L I + Sbjct: 243 LIGFTVNEPATGQLGVKAGELVDNAYGNNVVLASADGINPAGPAGVLDALAAAAVARSQG 302 Query: 303 XXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGL 362 AIA A+ F + HR +VVA DG+ ++D+SKATNPHAA ++ + V+WV GG Sbjct: 303 VAPEAIARALDSFEVAGHRGQVVAEHDGVHFIDNSKATNPHAADSALAGHDSVIWVVGGQ 362 Query: 363 LKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVV 422 LKGA + V + ++ A+++G DRA + AL HA V V + A+ + Sbjct: 363 LKGADIAPLVKKHEQRIKAALVLGADRAEIVAALKEHASQASV--FVTDKTEPFEAMEEI 420 Query: 423 SGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFA 482 T+ SIS +PGDTVLLAPA AS D F G RGD FA Sbjct: 421 V-TEAFSIS----------------------EPGDTVLLAPAAASLDMFKGMGQRGDLFA 457 Query: 483 TAVRAAIR 490 + I+ Sbjct: 458 HNIIGTIK 465 >tr|C2BNI7|C2BNI7_9CORY Tax_Id=525264 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium pseudogenitalium ATCC 33035] Length = 437 Score = 281 bits (718), Expect = 2e-73 Identities = 187/471 (39%), Positives = 238/471 (50%), Gaps = 43/471 (9%) Query: 27 LTRFGMAATLCDDDPAALQQYADN-GXXXXXXXXXXQQMFERGRKYVLVVTSPGFAPTTP 85 L G+ T+ D + AL + A+ G Q F+ LVVTSPG+ P +P Sbjct: 2 LASLGVDTTVADSNETALAELAEEFGVATVSVDSAAQGDFD------LVVTSPGWRPDSP 55 Query: 86 VLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAMLAAD--- 142 +LVA A V + GDVELA+RLD AG +G PR WLVV ML ++ AD Sbjct: 56 LLVAFQDAGVEVIGDVELAYRLDRAGVFGAPRTWLVVTGTNGKTTTTGMLAQIMQADAKR 115 Query: 143 -NRRSLLCGNIGRPVLDVLTEFAEPS-DFLAVELSSFQLHWAPSLRPEAGVVLNIAEDHL 200 +R+L GNIG + D LT A P D L ELSSFQLHW+ LRP+ GV+LN+A+DHL Sbjct: 116 TGKRALAVGNIGVSLFDALT--ATPRLDVLCAELSSFQLHWSSHLRPDVGVLLNLADDHL 173 Query: 201 DWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGVRD 260 DWH + Y AKA+VL+G VAVVG DD+ A + T GF EP GE+GV Sbjct: 174 DWHGSFDAYARAKAKVLSGDVAVVGKDDAEAVRYAADTAD--LYGFTAAEPTQGEVGVSA 231 Query: 261 GYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVALFRLGRH 320 G LV R + L I + +IA +A + + H Sbjct: 232 GRLVSRLNEQREDLASAEGIEPAGLAGVLDAAAAASVARLAGATPESIAQGLAAYTVAGH 291 Query: 321 RAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQLV 380 R VV GI ++D+SKATNPHAA ++ V+W+AGG LKGA VD VA+ A + Sbjct: 292 RGAVVHEHSGITFIDNSKATNPHAADAALKGLNSVIWIAGGQLKGAEVDGLVAKHAAHIK 351 Query: 381 GAVLIGRDRAMVAEALSRHAPNVPVVQVVAGED-AGMHAVAVVSGTDVISISDVGGTIGT 439 AV++G DR VA AL+ HAP+ PV + E A MHA + Sbjct: 352 AAVVLGVDREEVARALAAHAPHAPVDVIETQEPVAAMHAAVEAA---------------- 395 Query: 440 RVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATAVRAAIR 490 A GDTVLLAPA AS D ++G A RGD FA A R R Sbjct: 396 ----------LQHADAGDTVLLAPAAASLDMYTGMAQRGDFFAAAARELTR 436 >tr|C0XS04|C0XS04_9CORY Tax_Id=525263 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium lipophiloflavum DSM 44291] Length = 475 Score = 280 bits (717), Expect = 2e-73 Identities = 185/473 (39%), Positives = 236/473 (49%), Gaps = 36/473 (7%) Query: 19 TGRAVLAALTRFGMAATLCDDDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTSP 78 +GR L G+ + DD+PA ++ + ++ F + +VVTSP Sbjct: 26 SGRGAARLLDAVGVRCVVADDNPAHRERVSRETSAIAVDTVEAEERFG---EVSVVVTSP 82 Query: 79 GFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHAM 138 G+ P P+LVAA A + + GDVEL +RLD AG +GPPR WLVV ML ++ Sbjct: 83 GWRPDAPLLVAAQRAGLEVIGDVELCFRLDRAGVFGPPRTWLVVTGTNGKTTTTGMLASI 142 Query: 139 LAADNR----RSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGVVLN 194 + ++ R+ CGNIG V D L + A D L ELSSFQLHW+ L P+AGV+LN Sbjct: 143 MGEASKDSGLRAQACGNIGVAVSDALVD-AHRVDVLVAELSSFQLHWSQELVPDAGVLLN 201 Query: 195 IAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAPVRVGFRFGEPAVG 254 +A+DH+DWH + A Y AKA+VL RVAV G+DD+ A L + T GF GEP Sbjct: 202 LADDHIDWHGSFAAYAHAKAKVLQARVAVAGVDDAEVAKLAARTGRDDLYGFTLGEPGPR 261 Query: 255 ELGVRDGYLVDRAFAEDLALMPVTSIPVSXXXXXXXXXXXXXXXXXXXXXXTAIADAVAL 314 + GV LV + E L T I + I D + Sbjct: 262 QAGVLGDRLVFHSGTEVEELASATGIEPAGVAGVLDALAAAAVAVSQGVSPQRIDDGLRA 321 Query: 315 FRLGRHRAEVVAVADGIRYVDDSKATNPHAA---LVSVLAYPRVVWVAGGLLKGASVDAE 371 +R+ HR VV A+GI +VD+SKATNPHAA L VVWVAGG LKGASVD Sbjct: 322 YRVEGHRGAVVHAANGINWVDNSKATNPHAADSALAGAGQPGTVVWVAGGQLKGASVDEL 381 Query: 372 VARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVVSGTDVISIS 431 VA A L+G DR +V +A+S HAP VPV +S Sbjct: 382 VATHAHLFRAVALLGVDRGIVHKAVSEHAPGVPVF-----------------------VS 418 Query: 432 DVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFATA 484 D T M A+PGDTVLLAPA AS D FSG + RGD FA A Sbjct: 419 D--STDPAEAMDQCVRFAASQARPGDTVLLAPAAASLDMFSGMSARGDAFAAA 469 >tr|C1YQK2|C1YQK2_NOCDA Tax_Id=446468 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] Length = 448 Score = 279 bits (714), Expect = 5e-73 Identities = 183/423 (43%), Positives = 221/423 (52%), Gaps = 38/423 (8%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXX 132 LVVTSPG+ P +P+LV A+ A + + GDVELAWRL A WL V Sbjct: 50 LVVTSPGWRPDSPLLVRAAEAGIEVIGDVELAWRLKPADQV-----WLAVTGTNGKTTTV 104 Query: 133 SMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPS--DFLAVELSSFQLHWAPSLRPEAG 190 ML AML AD R +L GN+G PV++ + A + LAVELSSFQLHW+ SLRP A Sbjct: 105 RMLEAMLRADGRDALAVGNVGTPVVEAVQPDAGGRFREVLAVELSSFQLHWSSSLRPHAA 164 Query: 191 VVLNIAEDHLDWHSTMADYTMAKARVLT-GRVAVVGLDDSRAAALLSTTVAPVR--VGFR 247 VLNIA DHLDWH + Y AK R+ G + VV D+ + L P VGFR Sbjct: 165 TVLNIAPDHLDWHGGLDPYARAKGRIYAPGTLRVVNTADAWSVRLAEEDGDPHTPLVGFR 224 Query: 248 FGEPAVGELGVRDGYLVDRAFAEDL-----ALMPVTSIPVSXXXXXXXXXXXXXXXXXXX 302 P GE+GV + LVDRAF ED L ++ + + Sbjct: 225 LDTPRAGEVGVVEDLLVDRAFVEDPHSSAEELATLSDVRPAAPHNVANALAAAALARSVG 284 Query: 303 XXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGGL 362 ++ +A F HR VA A G+ YVDDSKATNPHAA S+ +YP VVW+AGGL Sbjct: 285 VYPGSVRAGLAAFDPEPHRIAFVATAGGVDYVDDSKATNPHAAAASLGSYPSVVWIAGGL 344 Query: 363 LKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAVV 422 LKGA VD A A +L AVLIG DRA + EAL+ HAP VPVV+V D Sbjct: 345 LKGAEVDDLAAMAADRLRAAVLIGADRARLREALAEHAPGVPVVEVEGPADG-------- 396 Query: 423 SGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTFA 482 GT VM LA+ GDTVLLAPA AS D F+ Y +RG FA Sbjct: 397 DGT---------------VMDAVVAAAASLAEEGDTVLLAPAAASMDMFTDYRERGRLFA 441 Query: 483 TAV 485 AV Sbjct: 442 EAV 444 >tr|C7QI97|C7QI97_CATAD Tax_Id=479433 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Catenulispora acidiphila] Length = 494 Score = 278 bits (711), Expect = 1e-72 Identities = 191/487 (39%), Positives = 229/487 (47%), Gaps = 42/487 (8%) Query: 20 GRAVLAALTRFGMAATLCD--DDPAALQQYADNGXXXXXXXXXXQQMFERGRKYVLVVTS 77 G + AAL G TL D DD A + A G + L+V + Sbjct: 26 GLSASAALLARGARVTLIDRYDDAATAGRAAGAAAQGAVVRLGDDATLPEGTE--LLVVT 83 Query: 78 PGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVXXXXXXXXXXSMLHA 137 PG P+ P++ AA AA VPIWGD ELAWRL A G WLVV M A Sbjct: 84 PGLPPSAPIVAAARAAGVPIWGDAELAWRLRAPLADGSYAPWLVVTGTNGKSTTVRMAEA 143 Query: 138 MLAADNRRSLLCGNIGRPVLDVLT------EFAEPSDFLAVELSSFQLHWAPSLRPEAGV 191 ML + CGNIG PVLD + E EP + L +ELSS+QL+W+ +L P A Sbjct: 144 MLKQAGKGVAACGNIGYPVLDAVLRGQAGGEAGEPFEVLVIELSSYQLYWSSTLSPLASA 203 Query: 192 VLNIAEDHLDWHSTMADYTMAKARVLTG-RVAVV----GLDDSRAAALLSTTVAPVRVGF 246 VLNIA DH+DWH + ADY AK R +VA V L+ R +GF Sbjct: 204 VLNIAPDHIDWHGSYADYVAAKGRAYENCQVAAVYNAADLETVRLVEEADVVEGCRAIGF 263 Query: 247 RFGEPAVGELGVRDGYLVDRAFAED-----LALMPVTSIPVSXXXXXXXXXXXXXXXXXX 301 G P + LGV DG L DRAF D L V + + Sbjct: 264 TLGAPGLSMLGVVDGILADRAFIADRRTNAAELGTVYDVEPNAPHNIANALAAAALVRAY 323 Query: 302 XXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGG 361 A+ D + FR HR VA DG+ +VDDSKATNPHAA S+ AY VVW+AGG Sbjct: 324 GVEPAAVRDGLREFRPEPHRIAWVATIDGVDFVDDSKATNPHAASASIGAYDHVVWLAGG 383 Query: 362 LLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAV 421 L KGA D V R A +L GAVL G +R +VAEAL R AP VPVV Sbjct: 384 LAKGADFDDLVERHAKRLRGAVLFGAERHLVAEALRRRAPEVPVV--------------- 428 Query: 422 VSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTF 481 + G V+ R +A GDTVLLAPA AS D F+ Y RGD F Sbjct: 429 -------DLGGPGPEQAAEVIAEAIAAARTMAVSGDTVLLAPACASMDMFTSYGQRGDVF 481 Query: 482 ATAVRAA 488 A AV+AA Sbjct: 482 AEAVKAA 488 >tr|B1W0I8|B1W0I8_STRGG Tax_Id=455632 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Streptomyces griseus subsp. griseus] Length = 476 Score = 277 bits (708), Expect = 3e-72 Identities = 182/426 (42%), Positives = 222/426 (52%), Gaps = 40/426 (9%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYG-PPRRWLVVXXXXXXXXX 131 LVVT+PG+ P P+ +AA+ A +P+WGDVELAWRL G G P WL V Sbjct: 74 LVVTAPGWQPDKPLFLAAAEAGIPVWGDVELAWRL--RGDDGRKPAPWLAVTGTNGKTTT 131 Query: 132 XSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGV 191 ML ++L A R+ GNIG +LD + E D LAVELSS+QLHWAPSLR + Sbjct: 132 VRMLASILRAAGLRTEAVGNIGVSLLDAVVGETE-YDVLAVELSSYQLHWAPSLRAHSAA 190 Query: 192 VLNIAEDHLDWHSTMADYTMAKARVLTGRVA--VVGLDDSRAAALL--STTVAPVR-VGF 246 VLN+A DHLDWH +M Y K RV G V + D L+ + V R +GF Sbjct: 191 VLNLAPDHLDWHGSMEAYAADKGRVYEGNTVACVYNVADPATEDLVREADVVEGCRAIGF 250 Query: 247 RFGEPAVGELGVRDGYLVDRAFAEDL-----ALMPVTSIPVSXXXXXXXXXXXXXXXXXX 301 G P +LGV DG LVDRAF D L V+ + Sbjct: 251 TLGAPGPSQLGVVDGILVDRAFVADRHKQAQELAEVSDVDPPAPHNIANALAAAALARAF 310 Query: 302 XXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGG 361 A+ D + FR HR E VA D +RYVDDSKATN HA S+ AY +VW+AGG Sbjct: 311 GVQPAAVRDGLRAFRPDAHRIEHVADLDEVRYVDDSKATNTHATEASLAAYDSIVWIAGG 370 Query: 362 LLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVAV 421 L KGA+ D V A +L G VLIG DRA++ EAL+RHAP VPVV + D G + AV Sbjct: 371 LAKGATFDELVIGAAKRLRGVVLIGADRALIREALTRHAPEVPVVD-LDRTDTGAMSEAV 429 Query: 422 VSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRGDTF 481 +LA+PGDTVLLAPA AS D F+ Y RG+ F Sbjct: 430 ARAA-------------------------ELARPGDTVLLAPACASMDMFTNYNKRGEAF 464 Query: 482 ATAVRA 487 A AVRA Sbjct: 465 ADAVRA 470 >tr|C9YVC5|C9YVC5_STRSW Tax_Id=680198 (murD)SubName: Full=Putative UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase;[Streptomyces scabies] Length = 473 Score = 275 bits (703), Expect = 1e-71 Identities = 185/428 (43%), Positives = 217/428 (50%), Gaps = 46/428 (10%) Query: 73 LVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRR-WLVVXXXXXXXXX 131 LVVT+PG+ P P+ AA AA + IWGD+ELAWRL GP WL V Sbjct: 71 LVVTAPGWKPDKPLFDAARAAGLEIWGDIELAWRLR-----GPDAAPWLAVTGTNGKTTT 125 Query: 132 XSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLRPEAGV 191 ML ++L A R+ GNIG +LDV+ EP D LAVELSS+QLHWAPSLR + Sbjct: 126 VQMLASILTAAGLRTAAVGNIGVSLLDVVLG-DEPYDVLAVELSSYQLHWAPSLRAHSAA 184 Query: 192 VLNIAEDHLDWHSTMADYTMAKARVLTG-RVAVVGLDDSRAAALLSTTVAPV-------R 243 VLN+A DHLDWH +M Y K RV G RVA V D+ V Sbjct: 185 VLNLAPDHLDWHGSMEAYAADKGRVYEGNRVACVYNVDATDKPSTEDLVREADVEEGCRA 244 Query: 244 VGFRFGEPAVGELGVRDGYLVDRAFAEDLA-----LMPVTSIPVSXXXXXXXXXXXXXXX 298 VGF G P +LGV DG LVDRAF E+ L V + Sbjct: 245 VGFTLGTPGPSQLGVVDGILVDRAFVENRQKNAQELAEVADVNPPAPHNIANALAAAALA 304 Query: 299 XXXXXXXTAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWV 358 A+ D + F HR VA DG+ Y+DDSKATN HAA S+ AY +VW+ Sbjct: 305 RAYGVPAAAVRDGLRAFTPDAHRIAHVADVDGVAYIDDSKATNTHAAQASLAAYESIVWI 364 Query: 359 AGGLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHA 418 AGGL KGA+ D VA A +L GAVLIG DRA++ EAL+RHAP VPVV Sbjct: 365 AGGLAKGATFDELVAGAAGRLRGAVLIGADRALIREALARHAPEVPVVD----------- 413 Query: 419 VAVVSGTDVISISDVGGTIGTRVMXXXXXXXRDLAQPGDTVLLAPAGASFDQFSGYADRG 478 + TD T M R LA+ GDTVLLAPA AS D F Y RG Sbjct: 414 ---LDRTD------------TGAMPAAVREARTLARAGDTVLLAPACASMDMFVNYNKRG 458 Query: 479 DTFATAVR 486 D FA AVR Sbjct: 459 DAFAEAVR 466 Database: Amellifera_nr Posted date: Jan 15, 2010 5:10 AM Number of letters in database: 3,808,957,724 Number of sequences in database: 11,153,314 Lambda K H 0.322 0.135 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11153314 Number of Hits to DB: 3,048,309,824 Number of extensions: 113916734 Number of successful extensions: 284245 Number of sequences better than 10.0: 2711 Number of HSP's gapped: 282251 Number of HSP's successfully gapped: 4211 Length of query: 490 Length of database: 3,808,957,724 Length adjustment: 142 Effective length of query: 348 Effective length of database: 2,225,187,136 Effective search space: 774365123328 Effective search space used: 774365123328 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 82 (36.2 bits)