BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= ML0961c (760 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,153,314 sequences; 3,808,957,724 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|O05564|METE_MYCLE Tax_Id=1769 (metE)RecName: Full=5-methyltet... 1355 0.0 tr|B8ZQS6|B8ZQS6_MYCLB Tax_Id=561304 (metE)SubName: Full=5-methy... 1355 0.0 sp|Q73WJ9|METE_MYCPA Tax_Id=1770 (metE)RecName: Full=5-methyltet... 1164 0.0 sp|P65340|METE_MYCTU Tax_Id=1773 (metE)RecName: Full=5-methyltet... 1161 0.0 sp|A5U1I0|METE_MYCTA Tax_Id=419947 (metE)RecName: Full=5-methylt... 1161 0.0 sp|A1KHS4|METE_MYCBP Tax_Id=410289 (metE)RecName: Full=5-methylt... 1161 0.0 sp|P65341|METE_MYCBO Tax_Id=1765 (metE)RecName: Full=5-methyltet... 1161 0.0 tr|C1AMC8|C1AMC8_MYCBT Tax_Id=561275 (metE)SubName: Full=Putativ... 1161 0.0 tr|A4KG62|A4KG62_MYCTU Tax_Id=395095 SubName: Full=5-methyltetra... 1161 0.0 sp|A0QC69|METE_MYCA1 Tax_Id=243243 (metE)RecName: Full=5-methylt... 1161 0.0 tr|C6DV27|C6DV27_MYCTK Tax_Id=478434 SubName: Full=5-methyltetra... 1160 0.0 tr|A5WLG0|A5WLG0_MYCTF Tax_Id=336982 SubName: Full=5-methyltetra... 1160 0.0 tr|B2HT14|B2HT14_MYCMM Tax_Id=216594 (metE)SubName: Full=5-methy... 1117 0.0 tr|A0PKM7|A0PKM7_MYCUA Tax_Id=362242 (metE)SubName: Full=5-methy... 1113 0.0 tr|B1ML47|B1ML47_MYCA9 Tax_Id=561007 SubName: Full=5-methyltetra... 1030 0.0 tr|A0R6Q9|A0R6Q9_MYCS2 Tax_Id=246196 (metE)SubName: Full=5-methy... 985 0.0 tr|C0ZN14|C0ZN14_RHOE4 Tax_Id=234621 (metE)SubName: Full=Cobalam... 933 0.0 tr|C3JE83|C3JE83_RHOER Tax_Id=596309 (metE)SubName: Full=5-methy... 927 0.0 tr|C1B6I2|C1B6I2_RHOOB Tax_Id=632772 (metE)SubName: Full=Cobalam... 924 0.0 sp|Q0S6X7|METE_RHOSR Tax_Id=101510 (metE)RecName: Full=5-methylt... 921 0.0 tr|A4FIY7|A4FIY7_SACEN Tax_Id=405948 (metE)SubName: Full=5-methy... 822 0.0 tr|A4FN94|A4FN94_SACEN Tax_Id=405948 (metE)SubName: Full=5-methy... 821 0.0 tr|C6W7X3|C6W7X3_ACTMD Tax_Id=446462 SubName: Full=5-methyltetra... 760 0.0 sp|Q93J59|METE_STRCO Tax_Id=1902 (metE)RecName: Full=5-methyltet... 752 0.0 tr|A8KZ21|A8KZ21_FRASN Tax_Id=298653 SubName: Full=5-methyltetra... 749 0.0 tr|C9N8F1|C9N8F1_9ACTO Tax_Id=591167 SubName: Full=5-methyltetra... 746 0.0 tr|B5GMA7|B5GMA7_STRCL Tax_Id=443255 SubName: Full=5-methyltetra... 743 0.0 tr|Q9KHC5|Q9KHC5_STRGR Tax_Id=67263 SubName: Full=5-methyltetrah... 733 0.0 sp|Q82LG4|METE_STRAW Tax_Id=33903 (metE)RecName: Full=5-methylte... 732 0.0 sp|B1VV57|METE_STRGG Tax_Id=455632 (metE)RecName: Full=5-methylt... 730 0.0 tr|A0JXH5|A0JXH5_ARTS2 Tax_Id=290399 SubName: Full=Methionine sy... 721 0.0 tr|C1RL61|C1RL61_9CELL Tax_Id=446466 SubName: Full=Methionine sy... 721 0.0 tr|C9KAH6|C9KAH6_9MICO Tax_Id=446469 SubName: Full=Methionine sy... 709 0.0 tr|A0LVN5|A0LVN5_ACIC1 Tax_Id=351607 SubName: Full=Methionine sy... 709 0.0 sp|A7HQP6|METE_PARL1 Tax_Id=402881 (metE)RecName: Full=5-methylt... 670 0.0 tr|C7QYL6|C7QYL6_JONDD Tax_Id=471856 SubName: Full=5-methyltetra... 666 0.0 tr|A7BDK3|A7BDK3_9ACTO Tax_Id=411466 SubName: Full=Putative unch... 665 0.0 tr|A4BR72|A4BR72_9GAMM Tax_Id=314278 SubName: Full=5-methyltetra... 664 0.0 tr|C8WU41|C8WU41_ALIAD Tax_Id=521098 SubName: Full=5-methyltetra... 663 0.0 sp|Q9AAW1|METE_CAUCR Tax_Id=155892 (metE)RecName: Full=5-methylt... 654 0.0 tr|B8GZU6|B8GZU6_CAUCN Tax_Id=565050 SubName: Full=5-methyltetra... 654 0.0 tr|C0W5C4|C0W5C4_9ACTO Tax_Id=525246 SubName: Full=5-methyltetra... 651 0.0 sp|Q87BY8|METE_XYLFT Tax_Id=183190 (metE)RecName: Full=5-methylt... 651 0.0 sp|B2I621|METE_XYLF2 Tax_Id=405441 (metE)RecName: Full=5-methylt... 651 0.0 tr|D0MEA5|D0MEA5_RHOMR Tax_Id=518766 SubName: Full=5-methyltetra... 651 0.0 tr|C1DC47|C1DC47_LARHH Tax_Id=557598 SubName: Full=5-methyltetra... 649 0.0 tr|A9AM89|A9AM89_BURM1 Tax_Id=395019 SubName: Full=5-methyltetra... 648 0.0 tr|B3D9R9|B3D9R9_BURM1 Tax_Id=395019 (metE)SubName: Full=5-methy... 648 0.0 sp|Q8XS05|METE_RALSO Tax_Id=305 (metE)RecName: Full=5-methyltetr... 648 0.0 tr|Q3R9R9|Q3R9R9_XYLFA Tax_Id=155920 SubName: Full=5-methyltetra... 648 0.0 >sp|O05564|METE_MYCLE Tax_Id=1769 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Mycobacterium leprae] Length = 760 Score = 1355 bits (3506), Expect = 0.0 Identities = 697/760 (91%), Positives = 697/760 (91%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA Sbjct: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA Sbjct: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP Sbjct: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW Sbjct: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLESALSKLATLLG LHVPYSLEPETDLDDNLRSWLAFG Sbjct: 301 RTDLESALSKLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDNLRSWLAFGAEKVAEV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DGR PRLHNGQVRARIDSIVASGTHRGDAAQRR Sbjct: 361 VVLARALRDGRDAVADEIAASNAAVASRRSDPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ Sbjct: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 IIQV QDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI Sbjct: 601 IIQVDEPALRELLPLRRADQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA Sbjct: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 >tr|B8ZQS6|B8ZQS6_MYCLB Tax_Id=561304 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate-homocystein methyltransferase;[Mycobacterium leprae] Length = 760 Score = 1355 bits (3506), Expect = 0.0 Identities = 697/760 (91%), Positives = 697/760 (91%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA Sbjct: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA Sbjct: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP Sbjct: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW Sbjct: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLESALSKLATLLG LHVPYSLEPETDLDDNLRSWLAFG Sbjct: 301 RTDLESALSKLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDNLRSWLAFGAEKVAEV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DGR PRLHNGQVRARIDSIVASGTHRGDAAQRR Sbjct: 361 VVLARALRDGRDAVADEIAASNAAVASRRSDPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ Sbjct: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 IIQV QDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI Sbjct: 601 IIQVDEPALRELLPLRRADQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA Sbjct: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 >sp|Q73WJ9|METE_MYCPA Tax_Id=1770 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Mycobacterium paratuberculosis] Length = 756 Score = 1164 bits (3010), Expect = 0.0 Identities = 588/755 (77%), Positives = 635/755 (84%) Query: 5 VTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLD 64 +T Q+FTATV GSPRIGP+RELKRATEGYWA RT R+ELE VA+TLRRD W+ LAAAGLD Sbjct: 1 MTPQAFTATVVGSPRIGPKRELKRATEGYWAGRTGRAELEKVAATLRRDTWAGLAAAGLD 60 Query: 65 SVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNY 124 SVPVNTFSYYDQMLDTA ML ALP R QVSDDLD+YFA ARGN+D+ PLEMTKWFDTNY Sbjct: 61 SVPVNTFSYYDQMLDTAVMLDALPERARQVSDDLDRYFAAARGNSDVAPLEMTKWFDTNY 120 Query: 125 HYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQR 184 HY+VPEI P T F+LNP K+L ELKEAL Q IP+RPV+IGP+TFLLLSKG++G GAPI+R Sbjct: 121 HYIVPEIAPTTKFALNPDKVLSELKEALAQGIPARPVVIGPITFLLLSKGVDGAGAPIER 180 Query: 185 LEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYV 244 LEELV IY LLSLLA+NGA+WVQ DEPALVTD+ DAPALAEAVY LGS S RPAIYV Sbjct: 181 LEELVPIYAELLSLLADNGAQWVQLDEPALVTDMCADAPALAEAVYNKLGSASNRPAIYV 240 Query: 245 ATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDL 304 ATYFG+PGASLAGLARTP+EAIGVD V G DT+VAAVPELAGKT+VAG+VDGRN+WRTDL Sbjct: 241 ATYFGDPGASLAGLARTPVEAIGVDLVYGPDTAVAAVPELAGKTVVAGVVDGRNVWRTDL 300 Query: 305 ESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXX 364 +AL KL TLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 AAALDKLTTLLGSAARVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGREKVAEVVTLA 360 Query: 365 XXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQD 424 DGR PRLHN +VRARIDSIVASG+HRGD AQRR SQD Sbjct: 361 RALRDGREAVADEIAASNAAVASRKSDPRLHNDRVRARIDSIVASGSHRGDPAQRRASQD 420 Query: 425 ARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLD 484 ARLHLPPLPTTTIGSYPQTSAIRKARAAL+ EID+AEY RMKKE+AD I LQEQLGLD Sbjct: 421 ARLHLPPLPTTTIGSYPQTSAIRKARAALRSGEIDQAEYERRMKKEIADVITLQEQLGLD 480 Query: 485 VLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWIT 544 VLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDV R HPMT+EWI+ Sbjct: 481 VLVHGEPERNDMVQYFAEQLEGFFATQNGWVQSYGSRCVRPPILYGDVVRTHPMTVEWIS 540 Query: 545 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQV 604 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQ+AGIA+IQV Sbjct: 541 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQAAGIAVIQV 600 Query: 605 XXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD 664 QDEYL WAV AFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD Sbjct: 601 DEPALRELLPLRRADQDEYLRWAVGAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD 660 Query: 665 ADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQ 724 ADVTS+EAARSHMEVLDDLNAVGF+NS+GPGVYDIHSPRVPST EIA+SLRAAL+A+P + Sbjct: 661 ADVTSLEAARSHMEVLDDLNAVGFSNSVGPGVYDIHSPRVPSTAEIAESLRAALRAVPAE 720 Query: 725 RLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 RLWVNPDCGLKTR+ DEVSASL+NMVAAA +VRAG Sbjct: 721 RLWVNPDCGLKTRNPDEVSASLKNMVAAAHEVRAG 755 >sp|P65340|METE_MYCTU Tax_Id=1773 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Mycobacterium tuberculosis] Length = 759 Score = 1161 bits (3004), Expect = 0.0 Identities = 588/759 (77%), Positives = 639/759 (84%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 M + V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAA Sbjct: 1 MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GA Sbjct: 121 DTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PI+RLEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RP Sbjct: 181 PIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+W Sbjct: 241 AIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLE+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 RTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DG PRLHNGQ+RARI++IVASG HRG+AAQRR Sbjct: 361 VVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 SQDARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+ Sbjct: 421 ASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQER 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+ Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTV 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 +IQV Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAI Sbjct: 601 VIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 +P +RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 721 VPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 759 >sp|A5U1I0|METE_MYCTA Tax_Id=419947 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Mycobacterium tuberculosis] Length = 759 Score = 1161 bits (3004), Expect = 0.0 Identities = 588/759 (77%), Positives = 639/759 (84%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 M + V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAA Sbjct: 1 MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GA Sbjct: 121 DTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PI+RLEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RP Sbjct: 181 PIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+W Sbjct: 241 AIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLE+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 RTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DG PRLHNGQ+RARI++IVASG HRG+AAQRR Sbjct: 361 VVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 SQDARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+ Sbjct: 421 ASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQER 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+ Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTV 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 +IQV Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAI Sbjct: 601 VIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 +P +RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 721 VPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 759 >sp|A1KHS4|METE_MYCBP Tax_Id=410289 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Mycobacterium bovis] Length = 759 Score = 1161 bits (3004), Expect = 0.0 Identities = 588/759 (77%), Positives = 639/759 (84%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 M + V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAA Sbjct: 1 MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GA Sbjct: 121 DTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PI+RLEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RP Sbjct: 181 PIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+W Sbjct: 241 AIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLE+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 RTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DG PRLHNGQ+RARI++IVASG HRG+AAQRR Sbjct: 361 VVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 SQDARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+ Sbjct: 421 ASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQER 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+ Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTV 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 +IQV Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAI Sbjct: 601 VIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 +P +RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 721 VPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 759 >sp|P65341|METE_MYCBO Tax_Id=1765 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Mycobacterium bovis] Length = 759 Score = 1161 bits (3004), Expect = 0.0 Identities = 588/759 (77%), Positives = 639/759 (84%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 M + V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAA Sbjct: 1 MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GA Sbjct: 121 DTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PI+RLEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RP Sbjct: 181 PIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+W Sbjct: 241 AIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLE+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 RTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DG PRLHNGQ+RARI++IVASG HRG+AAQRR Sbjct: 361 VVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 SQDARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+ Sbjct: 421 ASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQER 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+ Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTV 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 +IQV Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAI Sbjct: 601 VIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 +P +RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 721 VPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 759 >tr|C1AMC8|C1AMC8_MYCBT Tax_Id=561275 (metE)SubName: Full=Putative 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14;[Mycobacterium bovis] Length = 759 Score = 1161 bits (3004), Expect = 0.0 Identities = 588/759 (77%), Positives = 639/759 (84%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 M + V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAA Sbjct: 1 MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GA Sbjct: 121 DTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PI+RLEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RP Sbjct: 181 PIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+W Sbjct: 241 AIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLE+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 RTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DG PRLHNGQ+RARI++IVASG HRG+AAQRR Sbjct: 361 VVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 SQDARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+ Sbjct: 421 ASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQER 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+ Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTV 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 +IQV Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAI Sbjct: 601 VIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 +P +RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 721 VPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 759 >tr|A4KG62|A4KG62_MYCTU Tax_Id=395095 SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase metE;[Mycobacterium tuberculosis str. Haarlem] Length = 759 Score = 1161 bits (3004), Expect = 0.0 Identities = 588/759 (77%), Positives = 639/759 (84%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 M + V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAA Sbjct: 1 MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GA Sbjct: 121 DTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PI+RLEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RP Sbjct: 181 PIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIW 300 AIYVATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+W Sbjct: 241 AIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVW 300 Query: 301 RTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXX 360 RTDLE+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 RTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREV 360 Query: 361 XXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRR 420 DG PRLHNGQ+RARI++IVASG HRG+AAQRR Sbjct: 361 VVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRR 420 Query: 421 TSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQ 480 SQDARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+ Sbjct: 421 ASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQER 480 Query: 481 LGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTI 540 LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+ Sbjct: 481 LGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTV 540 Query: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA Sbjct: 541 EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA 600 Query: 601 IIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAI 660 +IQV Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAI Sbjct: 601 VIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAI 660 Query: 661 ADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKA 720 ADLDADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A Sbjct: 661 ADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRA 720 Query: 721 IPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 +P +RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 721 VPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 759 >sp|A0QC69|METE_MYCA1 Tax_Id=243243 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Mycobacterium avium] Length = 756 Score = 1161 bits (3003), Expect = 0.0 Identities = 586/755 (77%), Positives = 634/755 (83%) Query: 5 VTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLD 64 +T Q+FTATV GSPRIGP+RELKRATEGYWA RT R+ELE VA+TLRRD W+ LAAAGLD Sbjct: 1 MTPQAFTATVVGSPRIGPKRELKRATEGYWAGRTGRAELEKVAATLRRDTWAGLAAAGLD 60 Query: 65 SVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNY 124 SVPVNTFSYYDQMLDTA ML ALP R QVSDDLD+YFA ARGN+D+ PLEMTKWFDTNY Sbjct: 61 SVPVNTFSYYDQMLDTAVMLDALPERARQVSDDLDRYFAAARGNSDVAPLEMTKWFDTNY 120 Query: 125 HYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQR 184 HY+VPEI P T F+LNP K+L ELKEAL Q IP+RPV+IGP+TFLLLSKG++G G PI+R Sbjct: 121 HYIVPEIAPTTKFALNPDKVLSELKEALAQGIPARPVVIGPITFLLLSKGVDGAGGPIER 180 Query: 185 LEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYV 244 LEELV IY LLSLLA+NGA+WVQ DEPALVTD+ DAPALAEAVY LGS + RPAIYV Sbjct: 181 LEELVPIYAELLSLLADNGAQWVQLDEPALVTDMCADAPALAEAVYNKLGSAANRPAIYV 240 Query: 245 ATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDL 304 ATYFG+PGASLAGLARTP+EAIGVD V G DT+VAAVPELAGKT+VAG+VDGRN+WRTDL Sbjct: 241 ATYFGDPGASLAGLARTPVEAIGVDLVYGPDTAVAAVPELAGKTVVAGVVDGRNVWRTDL 300 Query: 305 ESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXX 364 +AL KL TLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 301 AAALDKLTTLLGSAARVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGREKVAEVVTLA 360 Query: 365 XXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQD 424 DGR PRLHN +VRARIDSIVASG+HRGD AQRR SQD Sbjct: 361 RALRDGREAVADEIAASNAAVASRKSDPRLHNDRVRARIDSIVASGSHRGDPAQRRASQD 420 Query: 425 ARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLD 484 ARLHLPPLPTTTIGSYPQTSAIRKARAAL+ EID+AEY RMKKE+AD I LQEQLGLD Sbjct: 421 ARLHLPPLPTTTIGSYPQTSAIRKARAALRSGEIDQAEYERRMKKEIADVITLQEQLGLD 480 Query: 485 VLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWIT 544 VLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDV R HPMT+EWIT Sbjct: 481 VLVHGEPERNDMVQYFAEQLEGFFATQNGWVQSYGSRCVRPPILYGDVVRTHPMTVEWIT 540 Query: 545 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQV 604 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQ+AGIA+IQV Sbjct: 541 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQAAGIAVIQV 600 Query: 605 XXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD 664 Q+EYL WAV AFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD Sbjct: 601 DEPALRELLPLRRADQEEYLRWAVGAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD 660 Query: 665 ADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQ 724 ADVTS+EAARSHMEVLDDLNAVGF+NS+GPGVYDIHSPRVPST EIA+SLRAAL+A+P + Sbjct: 661 ADVTSLEAARSHMEVLDDLNAVGFSNSVGPGVYDIHSPRVPSTAEIAESLRAALRAVPAE 720 Query: 725 RLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 RLWVNPDCGLKTR+ DEVSASL+NMVAAA +VRAG Sbjct: 721 RLWVNPDCGLKTRNPDEVSASLKNMVAAAHEVRAG 755 >tr|C6DV27|C6DV27_MYCTK Tax_Id=478434 SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase metE;[Mycobacterium tuberculosis] Length = 769 Score = 1160 bits (3001), Expect = 0.0 Identities = 587/755 (77%), Positives = 637/755 (84%) Query: 5 VTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLD 64 V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAAAGLD Sbjct: 15 VRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAAAGLD 74 Query: 65 SVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNY 124 SVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWFDTNY Sbjct: 75 SVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWFDTNY 134 Query: 125 HYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQR 184 HYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GAPI+R Sbjct: 135 HYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGAPIER 194 Query: 185 LEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYV 244 LEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RPAIYV Sbjct: 195 LEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRPAIYV 254 Query: 245 ATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDL 304 ATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+WRTDL Sbjct: 255 ATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVWRTDL 314 Query: 305 ESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXX 364 E+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 315 EAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREVVVLA 374 Query: 365 XXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQD 424 DG PRLHNGQ+RARI++IVASG HRG+AAQRR SQD Sbjct: 375 RALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRRASQD 434 Query: 425 ARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLD 484 ARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+LGLD Sbjct: 435 ARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQERLGLD 494 Query: 485 VLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWIT 544 VLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+EWIT Sbjct: 495 VLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTVEWIT 554 Query: 545 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQV 604 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA+IQV Sbjct: 555 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAVIQV 614 Query: 605 XXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD 664 Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAIADLD Sbjct: 615 DEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAIADLD 674 Query: 665 ADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQ 724 ADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A+P + Sbjct: 675 ADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRAVPAE 734 Query: 725 RLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 735 RLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 769 >tr|A5WLG0|A5WLG0_MYCTF Tax_Id=336982 SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase metE;[Mycobacterium tuberculosis] Length = 794 Score = 1160 bits (3001), Expect = 0.0 Identities = 587/755 (77%), Positives = 637/755 (84%) Query: 5 VTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLD 64 V Q FTAT+TGSPRIGPRRELKRATEGYWA RTSRSELE+VA+TLRRD WS LAAAGLD Sbjct: 40 VRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAAAGLD 99 Query: 65 SVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNY 124 SVPVNTFSYYDQMLDTA +LGALP RV+ VSD LD+YFA ARG + I PLEMTKWFDTNY Sbjct: 100 SVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWFDTNY 159 Query: 125 HYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQR 184 HYLVPEI P+TTF+L+PGK+L ELKEAL Q IP+RPVIIGP+TFLLLSK ++G GAPI+R Sbjct: 160 HYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGAPIER 219 Query: 185 LEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYV 244 LEELV +Y LLSLLA+ GA+WVQFDEPALVTDLSPDAPALAEAVYTAL SVS RPAIYV Sbjct: 220 LEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRPAIYV 279 Query: 245 ATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDL 304 ATYFG+PGA+L LARTP+EAIGVD V GADTSVA VPELAGKTLVAG+VDGRN+WRTDL Sbjct: 280 ATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVWRTDL 339 Query: 305 ESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXX 364 E+AL LATLLG LHVPYSLEPETDLDD LRSWLAFG Sbjct: 340 EAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREVVVLA 399 Query: 365 XXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQD 424 DG PRLHNGQ+RARI++IVASG HRG+AAQRR SQD Sbjct: 400 RALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRRASQD 459 Query: 425 ARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLD 484 ARLHLPPLPTTTIGSYPQTSAIR ARAAL+ EIDEAEY+ RM++E+ + I LQE+LGLD Sbjct: 460 ARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQERLGLD 519 Query: 485 VLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWIT 544 VLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDVSRP MT+EWIT Sbjct: 520 VLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTVEWIT 579 Query: 545 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQV 604 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA+IQV Sbjct: 580 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAVIQV 639 Query: 605 XXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD 664 Q EYL WAV AFRLATSGV+D+TQIHTHLCYSEFGEVIGAIADLD Sbjct: 640 DEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAIADLD 699 Query: 665 ADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQ 724 ADVTSIEAARSHMEVLDDLNA+GFAN +GPGVYDIHSPRVPS +E+A SLRAAL+A+P + Sbjct: 700 ADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRAVPAE 759 Query: 725 RLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 RLWVNPDCGLKTR+VDEV+ASL NMVAAAR+VRAG Sbjct: 760 RLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 794 >tr|B2HT14|B2HT14_MYCMM Tax_Id=216594 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE;[Mycobacterium marinum] Length = 763 Score = 1117 bits (2889), Expect = 0.0 Identities = 570/763 (74%), Positives = 630/763 (82%), Gaps = 3/763 (0%) Query: 1 MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 M +LV+ Q F AT+TGSPRIGPRRELKRATEGYWA RT+R+ELESVA+TLRRD W+DLAA Sbjct: 1 MTQLVSQQPFFATITGSPRIGPRRELKRATEGYWAGRTNRAELESVAATLRRDTWTDLAA 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWF 120 AGLDSVPVNTFSYYDQMLDTA +LGALP RVA + DDLD+YFA ARGN ++ PLEMTKWF Sbjct: 61 AGLDSVPVNTFSYYDQMLDTAVLLGALPTRVAGICDDLDRYFAAARGNAEVAPLEMTKWF 120 Query: 121 DTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA 180 DTNYHYLVPEI P T F L+P K+L ELKEA E IP+RPV+IGPVTFLLLSK ++G A Sbjct: 121 DTNYHYLVPEIGPDTRFGLHPDKVLAELKEAQELGIPARPVVIGPVTFLLLSKAVDGASA 180 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 PI RLEEL+ IY LLSLLA++GA+WVQ DEPALVTD+ PDAPALAE +YTALGS++ RP Sbjct: 181 PIGRLEELMPIYSELLSLLADSGAQWVQLDEPALVTDICPDAPALAERMYTALGSLANRP 240 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAV---PELAGKTLVAGIVDGR 297 AI+VATYFG+PGA+L LARTPIEAIGVD V GA T++A++ PELA KTLVAGIVDGR Sbjct: 241 AIHVATYFGDPGAALGALARTPIEAIGVDLVAGAHTAIASIVAAPELADKTLVAGIVDGR 300 Query: 298 NIWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXX 357 NIWRTDL++ALS+LATLLG LHVPYSLEPETDLD +LRSWLAFG Sbjct: 301 NIWRTDLQAALSRLATLLGSAASIAVSTSCSTLHVPYSLEPETDLDASLRSWLAFGAEKV 360 Query: 358 XXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAA 417 +GR PRLHNGQVRARI +I+ASG HRGDAA Sbjct: 361 AEVAVLARALREGREAVAAEIAASNEAVASRKKDPRLHNGQVRARIHAILASGVHRGDAA 420 Query: 418 QRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKL 477 RR SQ+ARL LPPLPTTTIGSYPQT+AIR ARAAL+ EIDEAEY RM+KE+AD I L Sbjct: 421 ARRLSQEARLQLPPLPTTTIGSYPQTTAIRTARAALRADEIDEAEYARRMEKEIADVIAL 480 Query: 478 QEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHP 537 QE+LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDV+R HP Sbjct: 481 QEKLGLDVLVHGEPERNDMVQYFAEQLDGFFATQNGWVQSYGSRCVRPPILYGDVARSHP 540 Query: 538 MTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSA 597 MT++WI+YAQSLT KPVKGMLTGPVTILAWSFVRDDQ L DTANQVALAIRDETVDLQSA Sbjct: 541 MTVDWISYAQSLTAKPVKGMLTGPVTILAWSFVRDDQALPDTANQVALAIRDETVDLQSA 600 Query: 598 GIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVI 657 GIA+IQV QD YL WAV AFRLATSGVADSTQIHTHLCYSEFGEVI Sbjct: 601 GIAVIQVDEPALRELLPLRRSEQDVYLRWAVAAFRLATSGVADSTQIHTHLCYSEFGEVI 660 Query: 658 GAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAA 717 GAIADLDADVTSIEAARSHMEVLDDLNA+GFANS+GPGVYDIHSPRVPS +E+A SLRAA Sbjct: 661 GAIADLDADVTSIEAARSHMEVLDDLNAIGFANSVGPGVYDIHSPRVPSAEEMADSLRAA 720 Query: 718 LKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 LKA+P RLW NPDCGLKTR+VDEV+ASLQNMVAAA++VR A Sbjct: 721 LKAVPAGRLWANPDCGLKTRNVDEVTASLQNMVAAAQKVRPEA 763 >tr|A0PKM7|A0PKM7_MYCUA Tax_Id=362242 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE;[Mycobacterium ulcerans] Length = 791 Score = 1113 bits (2879), Expect = 0.0 Identities = 568/761 (74%), Positives = 628/761 (82%), Gaps = 3/761 (0%) Query: 3 ELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAG 62 +LV+ Q F AT+TGSPRIGPRRELKRATEGYWA RT+R+ELESVA+TLRRD W+DLAAAG Sbjct: 31 QLVSQQPFFATITGSPRIGPRRELKRATEGYWAGRTNRAELESVAATLRRDTWTDLAAAG 90 Query: 63 LDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDT 122 LDSVPVNTFSYYDQMLDTA +LGALP RVA + DDLD+YFA ARGN ++ PLEMTKWFDT Sbjct: 91 LDSVPVNTFSYYDQMLDTAVLLGALPTRVAGICDDLDRYFAAARGNAEVSPLEMTKWFDT 150 Query: 123 NYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPI 182 NYHYLVPEI P T F L+P K+L ELKEA E I +RPV+IGPVTFLLLSK ++G API Sbjct: 151 NYHYLVPEIGPDTRFGLHPDKVLAELKEAQELGIRARPVVIGPVTFLLLSKAVDGASAPI 210 Query: 183 QRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAI 242 RLEEL+ IY LLSLLA++GA+WVQ DEPALVTD+ PDAPALAE +YTALGS++ RPAI Sbjct: 211 GRLEELMPIYSELLSLLADSGAQWVQLDEPALVTDICPDAPALAERMYTALGSLANRPAI 270 Query: 243 YVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAV---PELAGKTLVAGIVDGRNI 299 +VATYFG+PGA+L LARTPIEAIGVD V GA T++A++ PELA KTLVAGIVDGRNI Sbjct: 271 HVATYFGDPGAALGALARTPIEAIGVDLVAGAHTAIASIVAAPELADKTLVAGIVDGRNI 330 Query: 300 WRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXX 359 WRTDL++ALS+LATLLG LHVPYSLEPETDLD +LRSWLAFG Sbjct: 331 WRTDLQAALSRLATLLGSAASIAVSTSCSTLHVPYSLEPETDLDASLRSWLAFGAEKVAE 390 Query: 360 XXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQR 419 +GR PRLHNGQVRARI +I+ASG HRGDAA R Sbjct: 391 VAVLARALREGREAVAAEIAASNEAVASRKKDPRLHNGQVRARIHAILASGVHRGDAATR 450 Query: 420 RTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQE 479 R SQ+ARL LPPLPTTTIGSYPQT+AIR ARAAL+ EIDEAEY RM+KE+AD I LQE Sbjct: 451 RLSQEARLQLPPLPTTTIGSYPQTTAIRTARAALRADEIDEAEYARRMEKEIADVIALQE 510 Query: 480 QLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMT 539 +LGLDVLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDV+R HPMT Sbjct: 511 ELGLDVLVHGEPERNDMVQYFAEQLDGFFATQNGWVQSYGSRCVRPPILYGDVARSHPMT 570 Query: 540 IEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGI 599 ++WI+YAQSLT KPVKGMLTGPVTILAWSFVRDDQ L DTANQVALAIRDETVDLQSAGI Sbjct: 571 VDWISYAQSLTAKPVKGMLTGPVTILAWSFVRDDQALPDTANQVALAIRDETVDLQSAGI 630 Query: 600 AIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGA 659 A+IQV QD YL WAV AFRLATSGVADSTQIHTHLCYSEFGEVIGA Sbjct: 631 AVIQVDEPALRELLPLRRSEQDVYLRWAVAAFRLATSGVADSTQIHTHLCYSEFGEVIGA 690 Query: 660 IADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALK 719 IADLDADVTSIEAARSHMEVLDDLNA+GFANS+GPGVYDIHSPRVPS +E+A SLRAALK Sbjct: 691 IADLDADVTSIEAARSHMEVLDDLNAIGFANSVGPGVYDIHSPRVPSAEEMADSLRAALK 750 Query: 720 AIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 A+P RLW NPDCGLKTR+VDEV+ASLQNMVAAA++VR A Sbjct: 751 AVPAGRLWANPDCGLKTRNVDEVTASLQNMVAAAQKVRTEA 791 >tr|B1ML47|B1ML47_MYCA9 Tax_Id=561007 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase;[Mycobacterium abscessus] Length = 756 Score = 1030 bits (2664), Expect = 0.0 Identities = 526/756 (69%), Positives = 592/756 (78%) Query: 5 VTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLD 64 +TTQ AT GS RIGPRRELKRATE YWA R SR+ELE VA+ LRRD W+ LAAAGLD Sbjct: 1 MTTQPLKATTLGSARIGPRRELKRATESYWAGRISRAELEDVAAGLRRDNWTALAAAGLD 60 Query: 65 SVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNY 124 SVPVNTFSYYDQ+LDTA +LGALP RVA ++DDLD+YFA ARGN D+ PLEMTKWFDTNY Sbjct: 61 SVPVNTFSYYDQVLDTAVLLGALPPRVAGITDDLDRYFAAARGNADVTPLEMTKWFDTNY 120 Query: 125 HYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQR 184 HYLVPEI P T F LN K+ GELKEA IP+RPV++GPVTFL LSK I+G API+R Sbjct: 121 HYLVPEIGPGTKFELNDAKLFGELKEAQALDIPARPVVVGPVTFLALSKPIDGADAPIER 180 Query: 185 LEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYV 244 L+E+V +Y LL LAE G WVQ DEP LVTD+ P+ P LAE VY LG+V+ RPAI V Sbjct: 181 LDEVVTLYEQLLVRLAEAGVAWVQIDEPVLVTDILPNGPELAERVYGRLGTVADRPAILV 240 Query: 245 ATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDL 304 ATYFG+ GA+L LARTP+EAI VD V G+ ++V AVPEL+GKT+VAG+VDGRNIWRT+L Sbjct: 241 ATYFGDLGAALPALARTPVEAIAVDLVYGSVSTVTAVPELSGKTVVAGVVDGRNIWRTNL 300 Query: 305 ESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXX 364 ESAL LATL+G LHVPYSLEPE LDD LRSWLAFG Sbjct: 301 ESALGSLATLVGSAGAVAVSTSCSTLHVPYSLEPEAQLDDQLRSWLAFGEEKVKEVVVLA 360 Query: 365 XXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQD 424 +GR PRL+NGQ+RAR+D+I+A G RGDAA+RR SQD Sbjct: 361 RALSEGRDAVAAEIAASNAAAESRRTDPRLNNGQIRARLDAILADGVSRGDAAERRRSQD 420 Query: 425 ARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLD 484 RL LP LPTTTIGS+PQT IRKAR AL EID+AEY+ +M+ EVA+ I LQE+LGLD Sbjct: 421 ERLRLPTLPTTTIGSFPQTVEIRKARQALTRGEIDDAEYVRQMRAEVANVIALQEKLGLD 480 Query: 485 VLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWIT 544 VLVHGEPERNDMVQYFAEQL GFFATQNGWVQSYGSRCVRPPILYGDV+R PMT+EW T Sbjct: 481 VLVHGEPERNDMVQYFAEQLDGFFATQNGWVQSYGSRCVRPPILYGDVARRKPMTVEWAT 540 Query: 545 YAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQV 604 YAQSLT K VKGMLTGPVTILAWSFVRDDQPL DTANQ+ALAIRDETVDLQ+AGIAIIQV Sbjct: 541 YAQSLTQKHVKGMLTGPVTILAWSFVRDDQPLGDTANQIALAIRDETVDLQNAGIAIIQV 600 Query: 605 XXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLD 664 + YL WAV AFRL+TSGV+D+TQIHTHLCYSEFGEVIGAIADLD Sbjct: 601 DEPALRELLPLRNSEKQAYLDWAVGAFRLSTSGVSDATQIHTHLCYSEFGEVIGAIADLD 660 Query: 665 ADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQ 724 ADVTSIEAARSHMEVLDDLNA+GF+NS+GPGVYDIHSPRVPST+E+A SLR ALKA+P + Sbjct: 661 ADVTSIEAARSHMEVLDDLNAIGFSNSVGPGVYDIHSPRVPSTEEMATSLREALKAVPAR 720 Query: 725 RLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 RLWVNPDCGLKTR VDEV++SL N+VAAA VRA A Sbjct: 721 RLWVNPDCGLKTRKVDEVTSSLANLVAAAASVRADA 756 >tr|A0R6Q9|A0R6Q9_MYCS2 Tax_Id=246196 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; EC=2.1.1.14;[Mycobacterium smegmatis] Length = 771 Score = 985 bits (2547), Expect = 0.0 Identities = 505/763 (66%), Positives = 572/763 (74%), Gaps = 4/763 (0%) Query: 2 DELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAA 61 D L+T FTAT+ GSPRIGP RELKRA E YWA RS LESVA+ +RRD W L AA Sbjct: 9 DVLMTATPFTATILGSPRIGPNRELKRAVEKYWAGNLDRSGLESVAAKIRRDTWESLTAA 68 Query: 62 GLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNN----DIKPLEMT 117 GLDSVPVNTFSYYD +LDTA ++GALP RVA V+DDLD+YFA ARG DI PLEMT Sbjct: 69 GLDSVPVNTFSYYDHVLDTAVLVGALPPRVAGVADDLDRYFAAARGGTYDGTDIAPLEMT 128 Query: 118 KWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGING 177 KWFDTNYHY+VPE+ P T+F+L+P K++ EL+EA IP+RPV++GP+TFL LSK + G Sbjct: 129 KWFDTNYHYIVPELGPDTSFALHPAKVIEELREARALGIPARPVVVGPITFLALSKAVGG 188 Query: 178 GGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVS 237 API RL ELV +Y LL LLA+ G +WVQ DEP LVTD+ +A LA Y LG ++ Sbjct: 189 AVAPISRLGELVSVYGQLLELLADEGVQWVQIDEPVLVTDILDNAAELAGQTYKVLGGLA 248 Query: 238 KRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGR 297 KRPA++VA+YFG +L LARTP+EAIGVD V G +VAAVPEL KT+VAG+VDGR Sbjct: 249 KRPALFVASYFGELTDALPALARTPVEAIGVDLVAGTAAAVAAVPELTTKTVVAGVVDGR 308 Query: 298 NIWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXX 357 NIWRTDL+SAL LA+LLG LHVPY+L+ E++LD LRSWLAFG Sbjct: 309 NIWRTDLQSALGTLASLLGSVGNLAVSTSCSTLHVPYTLDAESELDPALRSWLAFGFEKV 368 Query: 358 XXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAA 417 GR PRL+N VR R+ SI+ASG RG AA Sbjct: 369 TEVVALARGLTQGREAIAGEIAASNDAIAARKSDPRLNNDHVRERLSSILASGAQRGPAA 428 Query: 418 QRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKL 477 +RR Q RL LPPLPTTTIGSYPQTSAIR ARA L++ ID AEY RMK E+A +KL Sbjct: 429 RRREVQQDRLGLPPLPTTTIGSYPQTSAIRVARAELRNGTIDTAEYERRMKHEIAGVVKL 488 Query: 478 QEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHP 537 QE LGLDVLVHGEPERNDMVQYFAEQL GFFAT+NGWVQSYGSRCVRPPILYGDV+RP P Sbjct: 489 QEDLGLDVLVHGEPERNDMVQYFAEQLTGFFATENGWVQSYGSRCVRPPILYGDVARPEP 548 Query: 538 MTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSA 597 MT+ W YAQSLTDKP+KGMLTGPVTILAWSFVRDDQPLADTA QVALAIRDETVDLQ+A Sbjct: 549 MTVSWAQYAQSLTDKPMKGMLTGPVTILAWSFVRDDQPLADTAAQVALAIRDETVDLQAA 608 Query: 598 GIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVI 657 GI IIQV Q YL WAV+AFRLATSGV DSTQIHTHLCYSEFGEVI Sbjct: 609 GIVIIQVDEPALRELLPLRSKDQAAYLKWAVEAFRLATSGVEDSTQIHTHLCYSEFGEVI 668 Query: 658 GAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAA 717 GAIADLDADVTSIEAARSHMEVLDDLNA GF N +GPGVYDIHSPRVP+T+E+A +LR A Sbjct: 669 GAIADLDADVTSIEAARSHMEVLDDLNAAGFGNGVGPGVYDIHSPRVPTTEEMATALRNA 728 Query: 718 LKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA 760 LKA+P +RLWVNPDCGLKTR DEV+ SL+NMV AAR+ RA A Sbjct: 729 LKAVPAERLWVNPDCGLKTRKTDEVTESLRNMVDAAREARADA 771 >tr|C0ZN14|C0ZN14_RHOE4 Tax_Id=234621 (metE)SubName: Full=Cobalamin-independent methionine synthase; EC=2.1.1.14;[Rhodococcus erythropolis] Length = 754 Score = 933 bits (2412), Expect = 0.0 Identities = 484/752 (64%), Positives = 559/752 (74%), Gaps = 1/752 (0%) Query: 7 TQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSV 66 T +FT+TV GSPRIGP RELKRATE YWA R L++VA LRR +DL GLDS+ Sbjct: 2 TTTFTSTVLGSPRIGPHRELKRATESYWAGRIDADALQAVARDLRRQGLADLRDLGLDSI 61 Query: 67 PVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHY 126 PVNTFS+YDQMLDTA +LGALP RVA V+D LD+YFA ARG + I PLEMTKWFDTNYHY Sbjct: 62 PVNTFSFYDQMLDTAVLLGALPDRVASVADPLDRYFAAARGTDTIAPLEMTKWFDTNYHY 121 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPEI P+TTF+L+P K+L EL EAL I +RPV+IGPVTFLLLSK + + RL+ Sbjct: 122 LVPEISPSTTFALDPSKVLSELAEALSDGIAARPVVIGPVTFLLLSKAVGTDEPLLSRLD 181 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 EL+ +Y LL LA+ GA WVQFDEPALV D + + A A Y L ++SKRP+I +A+ Sbjct: 182 ELLPLYADLLGRLAKAGASWVQFDEPALVGDRTDEEIEAARAAYEQLSALSKRPSILLAS 241 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDLES 306 YFG+ +L LA T +E VD V G D S+ +VPELA K +VAG+VDGRNIWR+DL+S Sbjct: 242 YFGSLRDALPALASTGVEGFAVDLVAGQD-SIGSVPELARKLIVAGVVDGRNIWRSDLDS 300 Query: 307 ALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXXXX 366 ALS L LLG LHVPY+L+ E+D+D LRSWLAFG Sbjct: 301 ALSTLGALLGSVDTLAVSTSCSLLHVPYTLDAESDVDKALRSWLAFGTEKVKEVVTLATA 360 Query: 367 XXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDAR 426 GR RL++ VR R+D+++ S T R AA+RR +QD Sbjct: 361 LTQGRESVEDEFALARAAASTRKDDRRLNDASVRGRLDAVLNSATGRAPAAERRAAQDEL 420 Query: 427 LHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVL 486 L LPPLPTTTIGSYPQTS IR ARAAL+ EIDEAEY++RM+ E+A+ + LQE+L LDVL Sbjct: 421 LSLPPLPTTTIGSYPQTSKIRIARAALRKGEIDEAEYVNRMRAEIAEVVALQEKLDLDVL 480 Query: 487 VHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYA 546 VHGEPERNDMVQYFAEQL GFFAT NGWVQSYG+RCVRPPILYGDVSRP MT++WITYA Sbjct: 481 VHGEPERNDMVQYFAEQLDGFFATANGWVQSYGTRCVRPPILYGDVSRPKQMTVDWITYA 540 Query: 547 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVXX 606 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLAD+ANQVALAIRDETVDLQ+AGI IIQV Sbjct: 541 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLADSANQVALAIRDETVDLQAAGIGIIQVDE 600 Query: 607 XXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDAD 666 Q YL W+V AFRLATSGVADST IHTHLCYSEFG VIGAIA LDAD Sbjct: 601 PALRELLPLRAEDQRAYLDWSVGAFRLATSGVADSTAIHTHLCYSEFGAVIGAIAGLDAD 660 Query: 667 VTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRL 726 VTSIEAARSHMEVLDDL++VGF +GPGVYDIHSPRVPS DEIA+SLR ALKA+P++RL Sbjct: 661 VTSIEAARSHMEVLDDLSSVGFDLGVGPGVYDIHSPRVPSVDEIAESLREALKAVPVERL 720 Query: 727 WVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 WVNPDCGLKTR EV ASL+N+V AA+ VRA Sbjct: 721 WVNPDCGLKTRGPIEVEASLRNLVEAAKVVRA 752 >tr|C3JE83|C3JE83_RHOER Tax_Id=596309 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; EC=2.1.1.14;[Rhodococcus erythropolis SK121] Length = 754 Score = 927 bits (2397), Expect = 0.0 Identities = 483/752 (64%), Positives = 556/752 (73%), Gaps = 1/752 (0%) Query: 7 TQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSV 66 T +FT+TV GSPRIGP RELKRATE YWA R L++VA LRR +DL GLDSV Sbjct: 2 TTTFTSTVLGSPRIGPHRELKRATESYWAGRIDADALQAVARDLRRQGLADLRDLGLDSV 61 Query: 67 PVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHY 126 PVNTFS+YDQMLDTA +LGALP RVA V+D LD+YFA ARG + I PLEMTKWFDTNYHY Sbjct: 62 PVNTFSFYDQMLDTAVLLGALPDRVASVADPLDRYFAAARGTDTIAPLEMTKWFDTNYHY 121 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPEI P+TTF+L+P K+L EL EAL I +RPV+IGPVTFLLLSK + + RLE Sbjct: 122 LVPEISPSTTFALDPSKVLSELAEALSDGIAARPVVIGPVTFLLLSKAVGTDEPLLSRLE 181 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 EL+ +Y LL LA+ GA WVQ DEPALV D + + A A Y L ++S+RP+I +A+ Sbjct: 182 ELLPLYADLLGRLAKAGASWVQLDEPALVGDRTDEEIEAARAAYEQLSALSERPSILLAS 241 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDLES 306 YFG+ +L LA T +E VD V G D S+ +VPELA K +VAG+VDGRNIWR+DL+S Sbjct: 242 YFGSLREALPALASTGVEGFAVDLVAGQD-SIGSVPELARKLVVAGVVDGRNIWRSDLDS 300 Query: 307 ALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXXXX 366 ALS L LLG LHVPY+L+ E D+D LRSWLAFG Sbjct: 301 ALSTLGALLGSVDNLAVSTSCSLLHVPYTLDAEADVDKALRSWLAFGTEKVKEVVTLATA 360 Query: 367 XXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDAR 426 GR RL++ VR R+ +++ S T R AA+RR +QD Sbjct: 361 LTQGRESVEDEFALARAAASTRKDDRRLNDASVRGRLAAVLNSATGRAPAAERRAAQDEL 420 Query: 427 LHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVL 486 L LPPLPTTTIGSYPQTS IR ARAAL+ EIDEAEY++RM+ E+A+ + LQE+L LDVL Sbjct: 421 LSLPPLPTTTIGSYPQTSKIRIARAALRKGEIDEAEYVNRMRAEIAEVVALQEKLDLDVL 480 Query: 487 VHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYA 546 VHGEPERNDMVQYFAEQL GFFAT NGWVQSYG+RCVRPPILYGDVSRP MT++WITYA Sbjct: 481 VHGEPERNDMVQYFAEQLDGFFATANGWVQSYGTRCVRPPILYGDVSRPKQMTVDWITYA 540 Query: 547 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVXX 606 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLAD+ANQVALAIRDETVDLQ+AGI IIQV Sbjct: 541 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLADSANQVALAIRDETVDLQAAGIGIIQVDE 600 Query: 607 XXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDAD 666 Q YL W+V AFRLATSGVADST IHTHLCYSEFG VIGAIA LDAD Sbjct: 601 PALRELLPLRAEDQRAYLDWSVGAFRLATSGVADSTAIHTHLCYSEFGAVIGAIAGLDAD 660 Query: 667 VTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRL 726 VTSIEAARSHMEVLDDL++VGF +GPGVYDIHSPRVPS DEIA+SLR ALKA+P++RL Sbjct: 661 VTSIEAARSHMEVLDDLSSVGFDLGVGPGVYDIHSPRVPSVDEIAESLREALKAVPVERL 720 Query: 727 WVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 WVNPDCGLKTR EV ASL+N+V AA+ VRA Sbjct: 721 WVNPDCGLKTRGSVEVEASLRNLVEAAKLVRA 752 >tr|C1B6I2|C1B6I2_RHOOB Tax_Id=632772 (metE)SubName: Full=Cobalamin-independent methionine synthase; EC=2.1.1.14;[Rhodococcus opacus] Length = 753 Score = 924 bits (2387), Expect = 0.0 Identities = 481/753 (63%), Positives = 556/753 (73%), Gaps = 2/753 (0%) Query: 7 TQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSV 66 T FTATV GSPRIGP RELK+A E YWA R + L V + LRR W+DL AGLDS+ Sbjct: 2 TTLFTATVLGSPRIGPNRELKKAVEAYWAGRADAAALTEVGADLRRRNWTDLRDAGLDSI 61 Query: 67 PVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHY 126 PVNTFSYYDQ+LDTA MLGALP RVA + +DLD+YFA ARG + + PLEMTKWFDTNYHY Sbjct: 62 PVNTFSYYDQVLDTAVMLGALPDRVAGIGNDLDRYFAAARGTDTVTPLEMTKWFDTNYHY 121 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPEI P+TTF+L+ K++GEL EALE I +RPVI+GPVTFLLLSK + ++R++ Sbjct: 122 LVPEIAPSTTFTLDASKVIGELGEALELGIAARPVIVGPVTFLLLSKTVGSDAPLLERID 181 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 ELV +Y LL+ L ++GA WVQ DEPALV D +P A A+ VY L +V RPAI +A+ Sbjct: 182 ELVPLYADLLTRLHDSGAEWVQIDEPALVADRTPQEIATAKRVYDQLSAVESRPAILLAS 241 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDLES 306 YFG+ G +L LA T +E I VD V G+DT +AAVPEL K +VAG+VDGRN+WRTDLE Sbjct: 242 YFGSLGDALPALASTGVEGIAVDLVAGSDT-LAAVPELTRKHVVAGVVDGRNVWRTDLEH 300 Query: 307 ALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXXXX 366 AL+ L T LG LHVPY+L+ E +D LRSWLAFG Sbjct: 301 ALTTLGTALGSTGSLAVSTSCSLLHVPYTLDAERSVDAALRSWLAFGSEKVREVVTLATA 360 Query: 367 XXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDAR 426 GR RLH+G +RAR++SI++S R A +RR +Q A Sbjct: 361 LTQGRQAVEGRFALDRAARATRATDSRLHDGAIRARLESILSSDPGRSPADRRREAQ-AG 419 Query: 427 LHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVL 486 L+LP LPTTTIGSYPQT+ IR ARA+L+ I +AEY RM+ E+AD I LQE+LGLDVL Sbjct: 420 LNLPLLPTTTIGSYPQTTEIRLARASLRKGAITKAEYHDRMRAEIADVIALQEKLGLDVL 479 Query: 487 VHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYA 546 VHGEPERNDMVQYFAEQL GFFAT+NGWVQSYGSRCVRPPILYGDV RP+PMT++WITYA Sbjct: 480 VHGEPERNDMVQYFAEQLDGFFATENGWVQSYGSRCVRPPILYGDVRRPNPMTVDWITYA 539 Query: 547 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVXX 606 QSLT +PVKGMLTGPVTILAWSFVRDDQPLAD+ANQVALAIRDETVDLQ AGI I+QV Sbjct: 540 QSLTQRPVKGMLTGPVTILAWSFVRDDQPLADSANQVALAIRDETVDLQGAGIRIVQVDE 599 Query: 607 XXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDAD 666 Q YL W+V AFRLATSGVAD+TQIHTHLCYSEFGEVI AIA+LDAD Sbjct: 600 PALRELLPLRAAEQTAYLDWSVGAFRLATSGVADTTQIHTHLCYSEFGEVIDAIANLDAD 659 Query: 667 VTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRL 726 VTSIEAARSHMEVL DLNAVGF +GPGVYDIHSPRVPS EIA SLR AL A+P QRL Sbjct: 660 VTSIEAARSHMEVLGDLNAVGFDLGVGPGVYDIHSPRVPSVAEIATSLREALDAVPAQRL 719 Query: 727 WVNPDCGLKTRSVDEVSASLQNMVAAARQVRAG 759 WVNPDCGLKTR EV ASL+N+V AA+ VRAG Sbjct: 720 WVNPDCGLKTRGPVEVEASLRNLVDAAKLVRAG 752 >sp|Q0S6X7|METE_RHOSR Tax_Id=101510 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Rhodococcus sp.] Length = 753 Score = 921 bits (2381), Expect = 0.0 Identities = 480/752 (63%), Positives = 550/752 (73%), Gaps = 2/752 (0%) Query: 7 TQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSV 66 T SFTATV GSPRIGP RELK+A E YWA R L+++A LRR W+ L AGLDSV Sbjct: 2 TFSFTATVLGSPRIGPNRELKKAVESYWAGRLDAEGLDALARDLRRRTWTSLRDAGLDSV 61 Query: 67 PVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHY 126 PVNTFSYYD +LDTA MLGALP RVA + DLD+YFA ARGN+ + PLEMT+WFDTNYHY Sbjct: 62 PVNTFSYYDHVLDTAAMLGALPDRVAGIESDLDRYFAAARGNDTVAPLEMTRWFDTNYHY 121 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPEI P TTF+L+P K+L EL+EA IP+RPV++GPVTFLLLSK + + RL+ Sbjct: 122 LVPEISPTTTFALDPSKVLRELEEARALDIPARPVVVGPVTFLLLSKAVGSDAPLLDRLD 181 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 ELV +Y LL LA GA WVQ DEPALV D +P A A+ Y L + RPAI VA+ Sbjct: 182 ELVPLYADLLGRLAGAGADWVQIDEPALVADRNPKEIAAAKRAYDRLSGLELRPAILVAS 241 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDLES 306 YFG+ G +L +A T +E I +D V G+DT +A VP+L K +VAG+VDGRNIWRTDL++ Sbjct: 242 YFGSLGDALPAIASTGVEGIAIDLVAGSDT-LATVPDLTRKHVVAGVVDGRNIWRTDLDA 300 Query: 307 ALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXXXX 366 AL+ L TLLG LHVPY+L+ ET +D LRSWLAFG Sbjct: 301 ALASLGTLLGSTGSLAVSTSCSLLHVPYTLDAETGIDKALRSWLAFGTEKVREVVTLGTA 360 Query: 367 XXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDAR 426 GR RLH+ VRAR+D++ AS R AA+RR +Q A Sbjct: 361 LTSGRESVDDEFALARAAASTRNTDRRLHDATVRARLDALTASDPGRSPAAERREAQSA- 419 Query: 427 LHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVL 486 L LP LPTTTIGSYPQT+ IR ARAA + EIDEAEY+ RM+ EVAD + LQE+L LDVL Sbjct: 420 LSLPVLPTTTIGSYPQTTQIRVARAARRKGEIDEAEYLKRMRAEVADVVALQEKLDLDVL 479 Query: 487 VHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYA 546 VHGEPERNDMVQYFAEQL GFFAT NGWVQSYGSRCVRPPILYGDV R +PMT+EWITYA Sbjct: 480 VHGEPERNDMVQYFAEQLDGFFATDNGWVQSYGSRCVRPPILYGDVRRSNPMTVEWITYA 539 Query: 547 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVXX 606 QSLT +PVKGMLTGPVTILAWSFVRDDQPLAD+ANQVALAIRDETVDLQ AGI I+QV Sbjct: 540 QSLTQRPVKGMLTGPVTILAWSFVRDDQPLADSANQVALAIRDETVDLQGAGIRIVQVDE 599 Query: 607 XXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDAD 666 Q YL W+V AFRLATSGV+DSTQIHTHLCYSEFGEVI AIA LDAD Sbjct: 600 PALRELLPLRAADQPGYLDWSVGAFRLATSGVSDSTQIHTHLCYSEFGEVIEAIARLDAD 659 Query: 667 VTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRL 726 VTSIEAARSHMEVLDDL+AVGF +GPGVYDIHSPRVP +EIA SLR ALKA+P++RL Sbjct: 660 VTSIEAARSHMEVLDDLSAVGFDLGVGPGVYDIHSPRVPGVEEIAASLREALKAVPVERL 719 Query: 727 WVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 WVNPDCGLKTR EV ASL+N+V AA+ VRA Sbjct: 720 WVNPDCGLKTRGPAEVEASLRNLVDAAKLVRA 751 >tr|A4FIY7|A4FIY7_SACEN Tax_Id=405948 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase; EC=2.1.1.14;[Saccharopolyspora erythraea] Length = 761 Score = 822 bits (2123), Expect = 0.0 Identities = 437/758 (57%), Positives = 513/758 (67%), Gaps = 9/758 (1%) Query: 7 TQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSV 66 T +TV G PRIGP RELKRA E YWA R+ +L VA LR D W L AGLDSV Sbjct: 2 TTKIGSTVLGYPRIGPNRELKRALESYWASRSGAEDLREVARRLRVDTWRTLQDAGLDSV 61 Query: 67 PVNTFSYYDQMLDTAFMLGALPARVAQVS-DDLDQYFALARGNNDIKPLEMTKWFDTNYH 125 P NTFSYYDQ+LDTA GA+P R ++ + LD YFA+ARG + PLEMTKWFDTNYH Sbjct: 62 PGNTFSYYDQVLDTAVTFGAVPPRYTELGLNPLDTYFAMARGVDSTPPLEMTKWFDTNYH 121 Query: 126 YLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA---PI 182 YLVPEI P T FSL+ + +EA + + +RPV++GP+TFLLLSK G P+ Sbjct: 122 YLVPEIGPDTRFSLSDRTPVRLFQEAADLGVTTRPVLVGPLTFLLLSKSAEGAPESFHPL 181 Query: 183 QRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAI 242 +L+EL+ Y LL L GA WVQ DEPA D S A Y LG + RP + Sbjct: 182 DKLDELLTAYAELLGELKRAGAEWVQLDEPAFAADRSQTELDALRAAYRKLGELEGRPNL 241 Query: 243 YVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAG---KTLVAGIVDGRNI 299 VA YFG+ G +L LA P++A+GVD V G+ T V +P L+G KTLVAG+VDGRNI Sbjct: 242 LVAGYFGDLGDALDVLASAPVDALGVDLVAGSST-VDKLPTLSGLRNKTLVAGLVDGRNI 300 Query: 300 WRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXX 359 WRTDL+ AL+ ATLLG LHVPY +E E +D ++SWLAF Sbjct: 301 WRTDLDKALTTGATLLGLAGEVAVSTSCSLLHVPYDVEAEERIDPQVKSWLAFAVQKVRE 360 Query: 360 XXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQR 419 +GR R+ N VRAR+ S+ + R D A R Sbjct: 361 VVVLGRALREGRDAVADELAAAAAVADRAKAD-RVRNNHVRARLQSLRPEHSRRSDYALR 419 Query: 420 RTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQE 479 R +Q+ L LPPLPTTTIGS+PQT+ +RKARA L++ IDEA Y RM+ E+ I+LQE Sbjct: 420 REAQEKSLRLPPLPTTTIGSFPQTTDVRKARAELRNGTIDEAAYEQRMRDEIQRVIELQE 479 Query: 480 QLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMT 539 LGLDVLVHGEPERNDMVQYF+E + GF +T GWVQSYGSRCVRPPIL+GDVSRP PMT Sbjct: 480 GLGLDVLVHGEPERNDMVQYFSELMEGFVSTHKGWVQSYGSRCVRPPILFGDVSRPDPMT 539 Query: 540 IEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGI 599 +EW TYAQ LTDKPVKGMLTGPVTILAWSFVRDDQPLADTA QVALAIRDE DL+SAGI Sbjct: 540 VEWATYAQKLTDKPVKGMLTGPVTILAWSFVRDDQPLADTAGQVALAIRDEVRDLESAGI 599 Query: 600 AIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGA 659 ++QV +EYL WAV++FRLATSGVADSTQIHTHLCYSEFG+VI A Sbjct: 600 RVVQVDEPALRELLPLRSVRHEEYLDWAVESFRLATSGVADSTQIHTHLCYSEFGDVINA 659 Query: 660 IADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALK 719 I LDADVTSIEAARS MEVL DLNAVGFA +GPGVYDIHSPRVP T+E+ LRAAL+ Sbjct: 660 IVALDADVTSIEAARSRMEVLADLNAVGFARGVGPGVYDIHSPRVPETEEVTALLRAALE 719 Query: 720 AIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 A+P QRLWVNPDCGLKTR EV A+L+N+V+A VR Sbjct: 720 AVPAQRLWVNPDCGLKTRGYTEVEAALKNVVSATAAVR 757 >tr|A4FN94|A4FN94_SACEN Tax_Id=405948 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase; EC=2.1.1.14;[Saccharopolyspora erythraea] Length = 762 Score = 821 bits (2120), Expect = 0.0 Identities = 430/753 (57%), Positives = 512/753 (67%), Gaps = 6/753 (0%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTF 71 +TV G PRIGPRRELKRA EGYWA R++ +EL VA +LR W +LAAAGLDSVP NTF Sbjct: 7 STVLGHPRIGPRRELKRALEGYWASRSTEAELREVARSLRAGTWRELAAAGLDSVPGNTF 66 Query: 72 SYYDQMLDTAFMLGALPARVAQVS-DDLDQYFALARGNNDIKPLEMTKWFDTNYHYLVPE 130 SYYDQ+LDTA GA+P R A++ LD YFA+ARG PLEMTKWFDTNYHYLVPE Sbjct: 67 SYYDQVLDTAATFGAVPRRFAELGLGPLDTYFAMARGVESTPPLEMTKWFDTNYHYLVPE 126 Query: 131 IEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA---PIQRLEE 187 I P TTFSL + + +EA + +RPV++GP+TFLLLSK P+ +L+E Sbjct: 127 IGPGTTFSLADRTAVEDYREAAADGVGTRPVVVGPLTFLLLSKSAEDAPKSFRPLDKLDE 186 Query: 188 LVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVATY 247 LV Y LL+ L + GA WVQ DEPA D +P+ L Y L + +RP I VATY Sbjct: 187 LVQRYAELLTELHDAGAGWVQLDEPAFAADRTPEELELLRGAYRTLSQLDRRPDILVATY 246 Query: 248 FGNPGASLAGLARTPIEAIGVDFVCGADT--SVAAVPELAGKTLVAGIVDGRNIWRTDLE 305 FG+PG +L LA T +E I VD V A T S+A V L KTLV+G+VDGRN+WRTDL+ Sbjct: 247 FGDPGDALPTLASTDVEGIAVDLVSNASTVDSLARVDGLRSKTLVSGLVDGRNVWRTDLD 306 Query: 306 SALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXXX 365 +AL A LL LHVPY ++ E +LD ++R WLAF Sbjct: 307 AALGTAAALLEVAGEVAVSTSCSLLHVPYDVDAEANLDPHVRPWLAFAKQKAAEVVTLGR 366 Query: 366 XXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDA 425 +GR RL + +VR R+D++ A R RR +Q Sbjct: 367 ALREGRDSVADELAAARNAVQDRRSSERLRDNRVRGRLDALSADSYRRSPYDARRAAQRR 426 Query: 426 RLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDV 485 L LPPLPTTTIGS+PQT +RKARAAL++ ID+A Y RM +E++ I LQE LGLDV Sbjct: 427 TLDLPPLPTTTIGSFPQTPDVRKARAALRNGSIDQAAYDQRMLEEISRVIALQEALGLDV 486 Query: 486 LVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITY 545 LVHGEPERNDMVQYFAE L GF +T+NGWVQSYGSRCVRPPIL+GDVSRP P+T W Sbjct: 487 LVHGEPERNDMVQYFAEHLDGFVSTENGWVQSYGSRCVRPPILFGDVSRPEPITTRWAER 546 Query: 546 AQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVX 605 AQ LT+KPVKGMLTGP+TILAWSFVRDDQPL +TA QVALAIRDE DL++AGI +IQV Sbjct: 547 AQRLTEKPVKGMLTGPITILAWSFVRDDQPLGETAAQVALAIRDEVRDLEAAGIRVIQVD 606 Query: 606 XXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDA 665 ++YL WAV +FRLATSGVAD TQ+HTHLCYSEFGEVI AI LDA Sbjct: 607 EPALRELLPLRAEQHEDYLDWAVGSFRLATSGVADRTQVHTHLCYSEFGEVIDAIVALDA 666 Query: 666 DVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQR 725 DVTSIEAARS MEVLDDLNAVGF +GPGVYDIHSPRVPST+EI L AAL+++P +R Sbjct: 667 DVTSIEAARSRMEVLDDLNAVGFGRGVGPGVYDIHSPRVPSTEEIEGLLAAALRSVPAER 726 Query: 726 LWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 LWVNPDCGLKTR EV +L++MV AA ++RA Sbjct: 727 LWVNPDCGLKTRGYAEVEPALRSMVEAAARMRA 759 >tr|C6W7X3|C6W7X3_ACTMD Tax_Id=446462 SubName: Full=5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; EC=2.1.1.14;[Actinosynnema mirum] Length = 744 Score = 760 bits (1962), Expect = 0.0 Identities = 404/751 (53%), Positives = 494/751 (65%), Gaps = 13/751 (1%) Query: 7 TQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSV 66 T +TV G PRIGPRRELKRA E YWA RT R L + A+ LR D W DL AGLDSV Sbjct: 2 TSGIGSTVLGYPRIGPRRELKRAVESYWAGRTDRDALLATAARLRADTWRDLREAGLDSV 61 Query: 67 PVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHY 126 P NTFS+YDQ+LDTA ++GA+PAR Q ++D FA ARG + PLE+TKWFDTNYHY Sbjct: 62 PSNTFSFYDQVLDTAALVGAIPARYRQ-DHEVDTLFAAARGTGSLAPLELTKWFDTNYHY 120 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPEI+ TTF+L K L E +EA Q +P+RPV++GPVTFLLL+KG++ P+ RL+ Sbjct: 121 LVPEIDETTTFALTGDKPLAEHREARAQGVPTRPVVLGPVTFLLLAKGVD----PLSRLD 176 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 ELV +Y LL LA+ G WVQ DEPA D S E YT L + S RP + V Sbjct: 177 ELVEVYADLLRGLADEGVEWVQLDEPAFAADRSERELVALERAYTRLAAQSARPQLLVTG 236 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDLES 306 Y+G+ G +L LA T ++A+ VD V G++ +A V L GK LVAG+VDGRN+WRTDL + Sbjct: 237 YYGDLGRALGVLAGTAVDALAVDLVAGSEEGLAEVTALRGKILVAGLVDGRNVWRTDLRA 296 Query: 307 ALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXXXX 366 AL++ L LHVPY L+ E L + +R LAF Sbjct: 297 ALARAEALRPLAREVVVSTSSTLLHVPYDLDQEQGLGEEVRDRLAFARQKVHEVVLL--- 353 Query: 367 XXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDAR 426 GR PR H+G VR+R+ + R A R +Q + Sbjct: 354 ---GRALAEGPTEEWEAEADRPRPAPR-HDGAVRSRLTGLQPDARTRAPYADRVAAQ-SD 408 Query: 427 LHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVL 486 L LP L TTTIGS+PQT+ IR ARAAL+ E+D Y RM+ E+ I LQE +GLDVL Sbjct: 409 LGLPRLATTTIGSFPQTTEIRTARAALRSGELDLDGYAERMRTEIGRVIALQEDIGLDVL 468 Query: 487 VHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYA 546 VHGEPERNDMVQYFAE L G T+ GWVQSYGSRCVRPPIL+GDV+RP P+T+ W T+A Sbjct: 469 VHGEPERNDMVQYFAEHLDGVAGTELGWVQSYGSRCVRPPILHGDVTRPEPITVPWTTHA 528 Query: 547 QSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVXX 606 +SLT + VKGMLTGPVTILAWSFVRDDQPL TA+QVALA+RDE DL++AG +IQV Sbjct: 529 RSLTTRQVKGMLTGPVTILAWSFVRDDQPLRATADQVALALRDEIADLEAAGTRVIQVDE 588 Query: 607 XXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDAD 666 +++YL W+V AFRLAT G A TQ+HTHLCYSEFGEVI AI LDAD Sbjct: 589 PALRELLPLREADREDYLDWSVSAFRLATGGAAAGTQVHTHLCYSEFGEVIEAIDALDAD 648 Query: 667 VTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRL 726 VT+IEAARS MEVL DL+A GFA +GPGVYDIHSPRVP +E+ + A +A+P RL Sbjct: 649 VTTIEAARSKMEVLADLSAAGFARGVGPGVYDIHSPRVPGEEELVALIAEASRAVPGDRL 708 Query: 727 WVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 WVNPDCGLKTR+ EV +L+ +VAAA++VR Sbjct: 709 WVNPDCGLKTRAYAEVEPALRALVAAAKRVR 739 >sp|Q93J59|METE_STRCO Tax_Id=1902 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Streptomyces coelicolor] Length = 772 Score = 752 bits (1941), Expect = 0.0 Identities = 399/755 (52%), Positives = 485/755 (64%), Gaps = 9/755 (1%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTF 71 ATV G PR GP RELK+A EGYW R S EL S+A+ LR W LA AG+D VP F Sbjct: 12 ATVYGYPRQGPNRELKKAIEGYWKGRVSAPELRSLAADLRAANWRRLADAGIDEVPAGDF 71 Query: 72 SYYDQMLDTAFMLGALPAR--VAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHYLVP 129 SYYD +LDT M+GA+P R A +D LD YFA+ARG ++ PLEMTKWFDTNYHYLVP Sbjct: 72 SYYDHVLDTTVMVGAIPERHRAAVAADALDGYFAMARGTQEVAPLEMTKWFDTNYHYLVP 131 Query: 130 EIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA---PIQRLE 186 E+ P T F+ + K + EL EA+ + +RPV++GPVT+LLL+K G A P+ L+ Sbjct: 132 ELGPDTVFTADSTKQVTELAEAVALGLTARPVLVGPVTYLLLAKPAPGAPADFEPLTLLD 191 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 L+ +Y +L+ L GA WVQ DEPA V D +P E Y LG+++ RP + VA+ Sbjct: 192 RLLPVYAEVLTDLRAAGAEWVQLDEPAFVQDRTPAELNALERAYRELGALTDRPKLLVAS 251 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSV---AAVPELAGKTLVAGIVDGRNIWRTD 303 YF G +L LA+ PIE + +DF A T++ AAV L GK LVAG+V+GRNIW D Sbjct: 252 YFDRLGDALPVLAKAPIEGLALDFTDAAATNLDALAAVGGLPGKRLVAGVVNGRNIWIND 311 Query: 304 LESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXX 363 L+ +LS L TLLG LHVP E D++ + WLAF Sbjct: 312 LQKSLSTLGTLLGLADRVDVSASCSLLHVPLDTGAERDIEPQILRWLAFARQKTAEIVTL 371 Query: 364 XXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDA-AQRRTS 422 G P N VRAR +++ R A+R + Sbjct: 372 AKGLAQGTDAITGELAASRADMASRAGSPITRNPAVRARAEAVTDDDARRSQPYAERTAA 431 Query: 423 QDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLG 482 Q A L LPPLPTTTIGS+PQT IR ARA L+D ID A Y R++ E+ + I QE+ G Sbjct: 432 QRAHLGLPPLPTTTIGSFPQTGEIRAARADLRDGRIDIAGYEERIRAEIQEVISFQEKTG 491 Query: 483 LDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEW 542 LDVLVHGEPERNDMVQYFAEQL G+ ATQ+GWVQSYG+R VRPPIL GD+SRP PMT+ W Sbjct: 492 LDVLVHGEPERNDMVQYFAEQLTGYLATQHGWVQSYGTRYVRPPILAGDISRPEPMTVRW 551 Query: 543 ITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAII 602 TYAQSLT+KPVKGMLTGPVT+LAWSFVRDDQPL DTA QVALA+RDE DL++AG ++I Sbjct: 552 TTYAQSLTEKPVKGMLTGPVTMLAWSFVRDDQPLGDTARQVALALRDEVNDLEAAGTSVI 611 Query: 603 QVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIAD 662 QV YL WA +AFRL TSGV TQIHTH+CY+EFG+++ AI D Sbjct: 612 QVDEPALRETLPLRAADHTAYLAWATEAFRLTTSGVRPDTQIHTHMCYAEFGDIVQAIDD 671 Query: 663 LDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIP 722 LDADV S+EAARSHM+V +L G+ GPGVYDIHSPRVPS +E A LR LKAIP Sbjct: 672 LDADVISLEAARSHMQVAHELATHGYPREAGPGVYDIHSPRVPSAEEAAALLRTGLKAIP 731 Query: 723 MQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 +RLWVNPDCGLKTR E ASL+N+VA AR +R Sbjct: 732 AERLWVNPDCGLKTRGWPETRASLENLVATARTLR 766 >tr|A8KZ21|A8KZ21_FRASN Tax_Id=298653 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; EC=2.1.1.14;[Frankia sp.] Length = 766 Score = 749 bits (1935), Expect = 0.0 Identities = 402/759 (52%), Positives = 489/759 (64%), Gaps = 14/759 (1%) Query: 11 TATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNT 70 + TV G PRIGP RELK TE YWA R EL +A LR D+W DLAAAGLD++P NT Sbjct: 3 STTVAGYPRIGPARELKTTTEAYWADRLGEDELVWIAQQLRADVWKDLAAAGLDAIPSNT 62 Query: 71 FSYYDQMLDTAFMLGALPARVAQVSD-------DLDQYFALARGNNDIKPLEMTKWFDTN 123 FS+YDQ+LDTA + A+P R ++ L+ YFA+ARG + + PLEMTKWFDTN Sbjct: 63 FSFYDQVLDTAVLFDAVPDRFRGLTGAGGSPATPLETYFAMARGADGVAPLEMTKWFDTN 122 Query: 124 YHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA--- 180 YHYLVPE++P+T F L K L E++EA E + +RPV++GPVTFLLL+K G A Sbjct: 123 YHYLVPELDPSTRFRLVGDKPLREVREARELGVETRPVLVGPVTFLLLAKAAAGAPAGFR 182 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 P+ L++LVG Y LL LA + WVQ DEPAL DL+P A Y LG + RP Sbjct: 183 PLDLLDDLVGQYVELLDDLASDSVAWVQLDEPALTRDLTPAELAATARAYARLGGATTRP 242 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADT--SVAAVPELAGKTLVAGIVDGRN 298 I V+T+FG G +L L PI+ IG+D V G +VA + KTL G+V+G N Sbjct: 243 RILVSTFFGEAGEALPVLRDAPIDGIGLDLVAGPGNLDAVARAGGVGAKTLFVGVVNGHN 302 Query: 299 IWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXX 358 +WR DL +AL+ ATL G LHVP +E ET+LD L +AF Sbjct: 303 VWRADLPAALATCATLSGLAADVVVTTSCSLLHVPIDVEAETNLDPRLADRMAFARQKVE 362 Query: 359 XXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQ 418 GR +L + +VR R+ ++ RGD Sbjct: 363 EVVLLGTALRAGRDAVAAEIAAAEARRLAVPD--QLVDPRVRERLAALGEGWPTRGDLEH 420 Query: 419 RRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQ 478 R +Q A L LPPLPTTTIGS+PQT+AIR ARA+ + +DEA Y+ MK E+ + LQ Sbjct: 421 RVEAQAAALGLPPLPTTTIGSFPQTAAIRAARASRRAGTLDEAGYVRAMKTEIDQVVALQ 480 Query: 479 EQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPM 538 E +GLDVLVHGEPERNDMVQYFAE L G+ AT++GWVQSYG+R VRPPIL+GDVSRP PM Sbjct: 481 EDIGLDVLVHGEPERNDMVQYFAELLAGYAATEHGWVQSYGTRYVRPPILFGDVSRPEPM 540 Query: 539 TIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAG 598 T+ W YAQS T +PVKGMLTGPVT+LAWSFVRDDQPL TA QVALA+RDE L++AG Sbjct: 541 TLRWAAYAQSRTSRPVKGMLTGPVTMLAWSFVRDDQPLEVTARQVALALRDEIHGLEAAG 600 Query: 599 IAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIG 658 I IIQV YL WAV AFRLATS VA STQIHTH+CYSEFG++IG Sbjct: 601 IRIIQVDEPALRELLPPRRALWGAYLDWAVGAFRLATSSVAASTQIHTHMCYSEFGDIIG 660 Query: 659 AIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAAL 718 +I DLDADV S+EAARS ME++ DL G+ +IGPGVYDIHSPRVP+ DEI KSLR AL Sbjct: 661 SIDDLDADVASVEAARSRMELVTDLRKAGYRRAIGPGVYDIHSPRVPTVDEIEKSLRLAL 720 Query: 719 KAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 A+ RLW NPDCGLKTRS EV +L+NMV A R+VR Sbjct: 721 AAVEPARLWANPDCGLKTRSFTEVEPALRNMVTATRRVR 759 >tr|C9N8F1|C9N8F1_9ACTO Tax_Id=591167 SubName: Full=5-methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase;[Streptomyces flavogriseus ATCC 33331] Length = 772 Score = 746 bits (1925), Expect = 0.0 Identities = 396/762 (51%), Positives = 493/762 (64%), Gaps = 11/762 (1%) Query: 6 TTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDS 65 TT + +TV G PR G RELK+A EGYW R + L + A+ LRRD W L+ AG+D Sbjct: 6 TTAATRSTVYGYPRQGQNRELKKAVEGYWKGRVTADALRATAAGLRRDTWRQLSEAGIDE 65 Query: 66 VPVNTFSYYDQMLDTAFMLGALPAR--VAQVSDDLDQYFALARGNNDIKPLEMTKWFDTN 123 VP FSYYD +LDT+ M+GA+P R A +D LD YFA+ARG D PLEMTKWFDTN Sbjct: 66 VPTGDFSYYDHVLDTSVMVGAVPDRHREAVAADPLDGYFAMARGTQDAAPLEMTKWFDTN 125 Query: 124 YHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA--- 180 YHYLVPE+ P T F+ N K + EL EA+ + +RPV++GPVT+LLL+K G A Sbjct: 126 YHYLVPELGPDTVFAANSAKQVAELDEAVALGLTARPVLVGPVTYLLLAKPAPGVAADFE 185 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSP-DAPALAEAVYTALGSVSKR 239 P+ L+ L+ +Y +L+ L GA WVQ DEPALV D +P D A+A A YT LG ++ R Sbjct: 186 PLTLLDRLLPVYAEVLADLRAAGAEWVQLDEPALVQDRTPADLDAVARA-YTQLGGLADR 244 Query: 240 PAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSV---AAVPELAGKTLVAGIVDG 296 P + VA+YF G +L LARTPI+ + +DF A ++ AA L G+ LVAG+VDG Sbjct: 245 PGLLVASYFDRLGDALPVLARTPIDGLALDFTDAAAANLDDLAAAGGLPGRRLVAGVVDG 304 Query: 297 RNIWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXX 356 RNIW D E +L+ L TLLG LHVP E ++D + WLAF Sbjct: 305 RNIWINDYEKSLATLTTLLGLAGRVDVATSCSLLHVPLDTAAEEEIDPEILRWLAFARQK 364 Query: 357 XXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDA 416 +G P ++ V+AR D++ + R Sbjct: 365 TAEVATLARGLAEGTDAIAAEIAANRADLTSRADSPVTYDPAVQARADAVTDADGRRSQP 424 Query: 417 AQ-RRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAI 475 + R +Q A L LP LPTTT+GS+PQT +R ARA L+ D A Y R++KE+A+ I Sbjct: 425 YEVRAAAQRAHLGLPLLPTTTVGSFPQTDELRAARADLRTGRTDSAGYDERIRKEIAEVI 484 Query: 476 KLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRP 535 QE+ G+DVLVHGEPERNDMVQYFAE+L G+ AT++GWVQSYG+R VRPP+L GD+SRP Sbjct: 485 SYQERTGIDVLVHGEPERNDMVQYFAERLSGYLATRHGWVQSYGTRYVRPPVLAGDISRP 544 Query: 536 HPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQ 595 PMT+ W TYAQSLTD+PVKGMLTGPVT+LAWSFVRDDQPL DTA QVALA+RDE DL+ Sbjct: 545 EPMTVGWTTYAQSLTDRPVKGMLTGPVTMLAWSFVRDDQPLGDTARQVALALRDEVDDLE 604 Query: 596 SAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGE 655 SAGI++IQV + YL WA +AFRL+TSGV TQIHTH+CY+EFG+ Sbjct: 605 SAGISVIQVDEPALRETLPLRAAGRPAYLAWATEAFRLSTSGVRPDTQIHTHMCYAEFGD 664 Query: 656 VIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLR 715 ++ AI DLDADV S+EAARSHM+V +L G+ GPGVYDIHSPRVPS E A LR Sbjct: 665 IVQAIDDLDADVISLEAARSHMQVAHELADHGYPREAGPGVYDIHSPRVPSVRETASLLR 724 Query: 716 AALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 L AIP +RLWVNPDCGLKTR E ASL+N+VAAAR VR Sbjct: 725 TGLAAIPSERLWVNPDCGLKTRGWPETRASLENLVAAARTVR 766 >tr|B5GMA7|B5GMA7_STRCL Tax_Id=443255 SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase;[Streptomyces clavuligerus ATCC 27064] Length = 772 Score = 743 bits (1919), Expect = 0.0 Identities = 396/766 (51%), Positives = 492/766 (64%), Gaps = 13/766 (1%) Query: 5 VTTQSFTA----TVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAA 60 +TT+S A TV G PR G RELK+A EGYW R + L + A+ LRR W +LA Sbjct: 1 MTTKSAAAAARSTVYGYPRQGQGRELKKAIEGYWKGRVTADALTATAAELRRSNWRELAD 60 Query: 61 AGLDSVPVNTFSYYDQMLDTAFMLGALPAR--VAQVSDDLDQYFALARGNNDIKPLEMTK 118 AG+D VP FSYYD +LDT ++GA+P R A +D LD YFA+ARG ++ PLEMTK Sbjct: 61 AGIDEVPTGDFSYYDHVLDTTVLVGAIPERHRAAVAADALDGYFAMARGTQEVAPLEMTK 120 Query: 119 WFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGG 178 WFDTNYHYLVPE+ P T F+ NP K EL EALE RPV++GPVT+LLL+K G Sbjct: 121 WFDTNYHYLVPELGPDTVFTANPAKQTAELTEALELGHTPRPVLVGPVTYLLLAKPAPGV 180 Query: 179 GA---PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGS 235 A P+ L+ L+ +Y +L+ L GA WVQ DEPALV D +P A Y LG+ Sbjct: 181 AADFDPLTLLDRLLPVYAEILAALKAAGAEWVQLDEPALVQDRTPAELNAAARAYRELGA 240 Query: 236 VSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSV---AAVPELAGKTLVAG 292 ++ RP + VA+YF G +L+ LA+ P++ + +DF A ++ AAV L GK LVAG Sbjct: 241 LTDRPKLLVASYFDRLGEALSVLAKAPVDGLALDFTESAAANLDDLAAVGGLPGKRLVAG 300 Query: 293 IVDGRNIWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAF 352 +V+GRNIW +LE +LS L TLLG LHVP E D+D + WLAF Sbjct: 301 VVNGRNIWVNNLEKSLSTLGTLLGLADRVDVAASSSLLHVPLDAALERDIDPQILRWLAF 360 Query: 353 GXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTH 412 G P + VRAR +++ + Sbjct: 361 ARQKTTEIVTLAKGLAQGTAAIEGELSANRAALASRATSPITRDPAVRARSEAVTDADAR 420 Query: 413 RGDA-AQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEV 471 R QR +Q RL LP LPTTTIGS+PQT +R ARA L+ ID A Y R++ E+ Sbjct: 421 RSQPYGQRTVAQRERLGLPFLPTTTIGSFPQTDELRVARADLRAGRIDTAGYEDRIRAEI 480 Query: 472 ADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGD 531 A+ I QE+ G+DVLVHGEPERNDMVQYFAEQL G+ A ++GWVQSYG+R VRPP+L GD Sbjct: 481 AEVISFQEKTGVDVLVHGEPERNDMVQYFAEQLTGYLALRHGWVQSYGTRYVRPPVLAGD 540 Query: 532 VSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDET 591 +SRP PMT+ W T+AQSLTD+PVKGMLTGPVT+LAWSFVRDDQPLADTA QVALA+RDE Sbjct: 541 ISRPEPMTVRWTTHAQSLTDRPVKGMLTGPVTMLAWSFVRDDQPLADTARQVALALRDEV 600 Query: 592 VDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYS 651 DL++AG A+IQV +YL WA +AFR+ T GVA TQIHTH+CY+ Sbjct: 601 NDLEAAGTAVIQVDEPALRETLPLRAADHADYLAWATEAFRVTTGGVAPGTQIHTHMCYA 660 Query: 652 EFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIA 711 EFG+++ AI DLDADV S+EAARSHM+V +L A G+ GPGV+DIHSPRVPS +E A Sbjct: 661 EFGDIVQAIDDLDADVISLEAARSHMQVAHELAAHGYPREAGPGVWDIHSPRVPSAEEAA 720 Query: 712 KSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 + LR LKAIP +RLWVNPDCGLKTR E ASL+N+VAAAR VR Sbjct: 721 RLLRTGLKAIPAERLWVNPDCGLKTRGWAETRASLENLVAAARTVR 766 >tr|Q9KHC5|Q9KHC5_STRGR Tax_Id=67263 SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase-like protein;[Streptomyces griseus subsp. griseus] Length = 774 Score = 733 bits (1893), Expect = 0.0 Identities = 389/756 (51%), Positives = 479/756 (63%), Gaps = 9/756 (1%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTF 71 ATV G PR GP RELK+A EGYW R + L A+ LRR W LA AG+ VP F Sbjct: 12 ATVYGYPRQGPNRELKKAIEGYWKGRVDAAALRETAAELRRGTWQQLAEAGVHDVPTGDF 71 Query: 72 SYYDQMLDTAFMLGALPAR--VAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHYLVP 129 SYYD +LDT+ M+GA+P R A +D LD YFA+ARG D+ PLEMTKWFDTNYHYLVP Sbjct: 72 SYYDHVLDTSVMVGAVPGRHRAAVDADALDGYFAMARGTQDVAPLEMTKWFDTNYHYLVP 131 Query: 130 EIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA---PIQRLE 186 E+ P T F+ + K + E EAL RPV++GPVT+LLL+K G A P+ L+ Sbjct: 132 ELGPDTVFTADSAKQVAECAEALALGHTPRPVLVGPVTYLLLAKPAPGVAADFEPLTLLD 191 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 L+ +Y +L+ L GA WVQ DEPALV D +P A Y LG ++ RP + VA+ Sbjct: 192 RLLPVYAEVLADLRAAGAAWVQLDEPALVQDRTPAELNAAARAYRELGGLADRPQLLVAS 251 Query: 247 YFGNPGASLAGLARTPIEAIGVDFV---CGADTSVAAVPELAGKTLVAGIVDGRNIWRTD 303 YFG G +L LA+ P++ + +DF G +AA L GK LVAG+V+GRNIW D Sbjct: 252 YFGRLGEALTVLAKAPVDGLALDFTESGAGNLDDLAAAGGLPGKRLVAGVVNGRNIWIND 311 Query: 304 LESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXX 363 E +L+ L TLLG LHVP + E D+D + WLAF Sbjct: 312 YEKSLATLGTLLGLADRVDVSASCSLLHVPLDADAERDIDPQIARWLAFARQKTEEIVVL 371 Query: 364 XXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIV-ASGTHRGDAAQRRTS 422 G + VRAR ++ A G +R + Sbjct: 372 ARGLTGGTDTIAAELAANRADLASRAGAALTRDPAVRARTAAVTDADGRRSQPYTERSAA 431 Query: 423 QDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLG 482 Q A L LP LPTTTIGS+PQT+ +R ARA L+ IDEA Y R+K E+ + + QE+ G Sbjct: 432 QRAHLGLPLLPTTTIGSFPQTTELRTARADLRAGRIDEAGYEERIKDEIREVLSFQEKAG 491 Query: 483 LDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEW 542 LDVLVHGEPERNDMVQYFAEQL G+ ATQ+GWVQSYG+R VRPP+L GD+SRP PMT+ W Sbjct: 492 LDVLVHGEPERNDMVQYFAEQLTGYLATQHGWVQSYGTRYVRPPVLAGDISRPEPMTVRW 551 Query: 543 ITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAII 602 TYAQSLT +PVKGMLTGPVT+LAWSFVRDDQPL DTA QVALA+RDE DL+++G ++I Sbjct: 552 TTYAQSLTARPVKGMLTGPVTMLAWSFVRDDQPLGDTARQVALALRDEVNDLEASGTSVI 611 Query: 603 QVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIAD 662 QV YL WA ++FRLAT GV TQIHTH+CY+EFG+++ AI D Sbjct: 612 QVDEPALRETLPLRAAEHAAYLEWATESFRLATGGVRPDTQIHTHMCYAEFGDIVQAIDD 671 Query: 663 LDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIP 722 LDADV S+EAARSHM+V +L A G+ GPGVYDIHSPR+PST+E A LR L+AIP Sbjct: 672 LDADVISLEAARSHMQVARELAAHGYPREAGPGVYDIHSPRIPSTEEAAALLRKGLEAIP 731 Query: 723 MQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 RLWVNPDCGLKTR E ASL+N+VAAAR++RA Sbjct: 732 ASRLWVNPDCGLKTRGWPETRASLENLVAAAREIRA 767 >sp|Q82LG4|METE_STRAW Tax_Id=33903 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Streptomyces avermitilis] Length = 772 Score = 732 bits (1889), Expect = 0.0 Identities = 392/756 (51%), Positives = 479/756 (63%), Gaps = 9/756 (1%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTF 71 ATV G PR G RELK+A EGYW R L + A+ LRRD W LA AG+ VP F Sbjct: 12 ATVYGYPRQGRGRELKKAIEGYWKGRLDADALRTTATGLRRDTWQQLAEAGIHEVPTGDF 71 Query: 72 SYYDQMLDTAFMLGALPAR--VAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHYLVP 129 SYYD +LDT+ M+GA+PAR A +D LD YFA+ARG D+ PLEMTKWFDTNYHYLVP Sbjct: 72 SYYDHVLDTSVMVGAIPARHRAAVEADALDGYFAMARGTQDVAPLEMTKWFDTNYHYLVP 131 Query: 130 EIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA---PIQRLE 186 E+ P T FS + K + EL EAL + +RPV++GPVT+LLL+K G A P+ L+ Sbjct: 132 ELGPDTVFSTDSAKQVAELGEALALGLTARPVLVGPVTYLLLAKPAPGVAADFDPLTLLD 191 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 L+ +Y +L+ L GA WVQ DEPALV D +P AE Y LG ++ RP + VA+ Sbjct: 192 RLLPVYAEVLADLRAAGAEWVQLDEPALVQDRTPAELNAAERAYRVLGGLTDRPKLLVAS 251 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSV---AAVPELAGKTLVAGIVDGRNIWRTD 303 YF G +L LA P+E + +DF GA ++ AAV L GK LVAG+VDGRNIW D Sbjct: 252 YFDRLGDALPVLAEAPVEGLALDFAEGAAANLDALAAVGGLPGKRLVAGVVDGRNIWVND 311 Query: 304 LESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXX 363 LE +L+ L TLLG LHVP E D+ + WLAF Sbjct: 312 LEKSLALLGTLLGLADRVDVAASCSLLHVPLDAAAERDIAPQVLRWLAFARQKTAEIVTL 371 Query: 364 XXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHR-GDAAQRRTS 422 G + VR+R + + R G +R + Sbjct: 372 AKGLGHGTDAIAAQLAANRADLVSRADSALTRDPAVRSRTAATTDADARRSGPYPERAAA 431 Query: 423 QDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLG 482 Q ARL LP LPTTTIGS+PQT+ +R ARA L+ ID A Y R++ E+ + I QE+ G Sbjct: 432 QRARLGLPLLPTTTIGSFPQTAELRTARADLRAGRIDSAGYEERIRAEIGEVISFQEKAG 491 Query: 483 LDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEW 542 LDVLVHGE ERNDMVQYFAE+L G+ TQ+GWVQSYG+R VRPP+L GD+SRP PMT+ W Sbjct: 492 LDVLVHGEAERNDMVQYFAERLTGYLTTQHGWVQSYGTRYVRPPVLAGDISRPEPMTVPW 551 Query: 543 ITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAII 602 TYAQSLTD+PVKGMLTGPVT+LAWSFVRDDQPL +TA QVALA+RDE DL++AG ++I Sbjct: 552 TTYAQSLTDRPVKGMLTGPVTMLAWSFVRDDQPLGETARQVALALRDEVGDLEAAGTSVI 611 Query: 603 QVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIAD 662 QV + YL WA +AFRL T GV TQIHTH+CY+EFG+++ AI D Sbjct: 612 QVDEPALRETLPLRAADRPAYLAWATEAFRLTTGGVRPDTQIHTHMCYAEFGDIVQAIDD 671 Query: 663 LDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIP 722 LDADV S+EAARSHM+V +L + GPGVYDIHSPRVP DE A LR L+AIP Sbjct: 672 LDADVISLEAARSHMQVARELAEHAYPREAGPGVYDIHSPRVPGVDETAALLRKGLEAIP 731 Query: 723 MQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 +RLWVNPDCGLKTR E ASL+N+VAAAR VRA Sbjct: 732 AERLWVNPDCGLKTRGWPETRASLENLVAAARTVRA 767 >sp|B1VV57|METE_STRGG Tax_Id=455632 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Streptomyces griseus subsp. griseus] Length = 774 Score = 730 bits (1885), Expect = 0.0 Identities = 387/756 (51%), Positives = 477/756 (63%), Gaps = 9/756 (1%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTF 71 ATV G PR GP RELK+A EGYW R L A+ LRR W LA AG+ VP F Sbjct: 12 ATVYGYPRQGPHRELKKAIEGYWKGRVDADALRETAAELRRGTWQQLAEAGVHEVPTGDF 71 Query: 72 SYYDQMLDTAFMLGALPAR--VAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHYLVP 129 SYYD +LDT+ M+GA+P R + +D LD YFA+ARG D+ PLEMTKWFDTNYHYLVP Sbjct: 72 SYYDHVLDTSVMVGAVPERHRASVEADALDGYFAMARGTQDVAPLEMTKWFDTNYHYLVP 131 Query: 130 EIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGA---PIQRLE 186 E+ P T FS + K + E +EAL RPV++GP+T+LLL+K G A P+ L+ Sbjct: 132 ELGPDTVFSADSAKQVAEFREALALGWTPRPVLVGPLTYLLLAKAAPGVAADFEPLTLLD 191 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 L+ +Y +L+ L GA WVQ DEPALV D +P A Y LG + RP + VA+ Sbjct: 192 RLLPVYAEILADLRAAGATWVQLDEPALVQDRTPAELNAAARAYRELGGRADRPQLLVAS 251 Query: 247 YFGNPGASLAGLARTPIEAIGVDFV---CGADTSVAAVPELAGKTLVAGIVDGRNIWRTD 303 YFG G +LA LA+ P++ + +DF G +AA L GK LVAG+V+GRNIW D Sbjct: 252 YFGRLGEALAVLAKAPVDGLALDFTESGAGNLDDLAAAGGLPGKRLVAGVVNGRNIWIND 311 Query: 304 LESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXX 363 +L+ L TLLG LHVP + E +D WLAF Sbjct: 312 YAKSLATLGTLLGLADRVDVSASCSLLHVPLDADAERGIDPETARWLAFAKQKTEEIVVL 371 Query: 364 XXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIV-ASGTHRGDAAQRRTS 422 G + VRAR ++ A G A+R + Sbjct: 372 ARGLGSGTDAIASELAANRADLASRTGAALTRDPAVRARTAAVTEADGRRSQPYAERSAA 431 Query: 423 QDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLG 482 Q A L LP LPTTTIGS+PQT+ +R ARA L+ IDEAEY R+K E+ + + QE+ G Sbjct: 432 QRAGLGLPLLPTTTIGSFPQTTELRTARAELRAGRIDEAEYEERVKDEIREVLSFQEKAG 491 Query: 483 LDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEW 542 +DVLVHGEPERNDMVQYFAEQL G+ ATQ+GWVQSYG+R VRPP+L GD+SRP PMT+ W Sbjct: 492 IDVLVHGEPERNDMVQYFAEQLDGYLATQHGWVQSYGTRYVRPPVLAGDISRPEPMTVRW 551 Query: 543 ITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAII 602 TYAQSLT +PVKGMLTGPVT+LAWSFVRDDQPL DTA QVALA+RDE DL++ G ++I Sbjct: 552 TTYAQSLTARPVKGMLTGPVTMLAWSFVRDDQPLGDTARQVALALRDEVNDLEANGTSVI 611 Query: 603 QVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIAD 662 QV YL WA ++FR+ATSGV TQIHTH+CY+EFG+++ AI D Sbjct: 612 QVDEPALRETLPLRAAEHAAYLEWATESFRIATSGVRPDTQIHTHMCYAEFGDIVQAIDD 671 Query: 663 LDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIP 722 LDADV S+EAARSHM+V +L A G+ GPGVYDIHSPR+P +E A LR L+AIP Sbjct: 672 LDADVISLEAARSHMQVARELAAHGYPREAGPGVYDIHSPRIPGAEEAAALLRKGLEAIP 731 Query: 723 MQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 +RLWVNPDCGLKTR E ASL+N+VAAARQ+RA Sbjct: 732 AERLWVNPDCGLKTRGWPETRASLENLVAAARQIRA 767 >tr|A0JXH5|A0JXH5_ARTS2 Tax_Id=290399 SubName: Full=Methionine synthase (B12-independent); EC=2.1.1.14;[Arthrobacter sp.] Length = 786 Score = 721 bits (1862), Expect = 0.0 Identities = 389/771 (50%), Positives = 482/771 (62%), Gaps = 17/771 (2%) Query: 5 VTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLD 64 VTT +A++ G PRIG RRELK+A E YWA + + L++ A ++ + L GL Sbjct: 9 VTTPFPSASILGYPRIGRRRELKKAVEAYWAGKIDAAALDAAAKEIQLGTATRLQGLGLT 68 Query: 65 SVPV--NTFSYYDQMLDTAFMLGALPARVAQVSD-----DLDQYFALARGNNDIKPLEMT 117 TFS+YDQ+LD A LGA+PAR + + D+D YF LARGN + +PLEMT Sbjct: 69 EAAAVPGTFSFYDQVLDAAAHLGAVPARFGNLLNAEGQLDIDGYFTLARGNKEEQPLEMT 128 Query: 118 KWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGIN- 176 KWFDTNYHYLVPEI P T F+L +I+ E + AL + +RP I+GPVTFLLLSK + Sbjct: 129 KWFDTNYHYLVPEIGPETNFALTSNRIVEEFEYALANGVETRPYIVGPVTFLLLSKASDD 188 Query: 177 --GGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAV---YT 231 G +P+ RLE+++ +Y LL LA GA WVQ DEPALV D A + AV Y Sbjct: 189 APAGFSPLSRLEDILPVYTALLEKLAAAGASWVQLDEPALVVDQDTSAEEIQAAVARSYE 248 Query: 232 ALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVA 291 L + +RP ++V+T +G L LA T I+A+ VD GA S AA+ L KTLVA Sbjct: 249 VLSAAGRRPQLFVSTPYGALNGQLGTLAATNIDALHVDVFKGAVPSAAALAALGNKTLVA 308 Query: 292 GIVDGRNIWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLA 351 G+VDG NIWR DL ++ K+A L HVP+ +E ET L + LRSWLA Sbjct: 309 GVVDGHNIWRNDLAASAEKIAELKKSVTKLAISTSTSTQHVPHDVEEETQLSEQLRSWLA 368 Query: 352 FGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNG----QVRARIDSIV 407 F D G VRAR ++ Sbjct: 369 FADQKAVEVATLAGLLTDAAGSETGSVQSAIDEATRIIASRAAAEGVQRADVRARTAALT 428 Query: 408 ASGTHRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRM 467 A+ +R + R +Q+ LHLPPLPTTTIGS+PQTS IR ARA ++ +Y M Sbjct: 429 AADFNRSEYPVREAAQEEALHLPPLPTTTIGSFPQTSEIRSARARNNKGDLTNEQYEQLM 488 Query: 468 KKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPI 527 K E+ ++LQE+LG DVLVHGEPERNDMVQYFAE L GF T +GWVQSYGSRC RP I Sbjct: 489 KDEIKRVVELQEELGYDVLVHGEPERNDMVQYFAENLEGFDVTVHGWVQSYGSRCTRPSI 548 Query: 528 LYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAI 587 L+GDV+R P+T++W YAQSLT KP+KGMLTGPVTILAWSFVRDDQPL +TANQV LA+ Sbjct: 549 LWGDVTRSAPITVKWAEYAQSLTSKPMKGMLTGPVTILAWSFVRDDQPLGETANQVGLAL 608 Query: 588 RDETVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTH 647 RDE DL++AGI +IQV Q YL W+V +FRLAT+G ADSTQIHTH Sbjct: 609 RDEIADLEAAGIKVIQVDEPALRELLPLRKADQAAYLDWSVNSFRLATAGAADSTQIHTH 668 Query: 648 LCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPST 707 LCYSEFG +I AI LDADVTSIEAARS MEV+ DL + GF +GPGVYDIHSPRVP Sbjct: 669 LCYSEFGAIIDAIDGLDADVTSIEAARSRMEVVHDLESHGFGRGVGPGVYDIHSPRVPGE 728 Query: 708 DEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 E+ + L A+K +P ++LWVNPDCGLKTR E SL+N+VAA + VRA Sbjct: 729 QEVTELLSTAVKHVPSRQLWVNPDCGLKTRGYAETEESLRNLVAATKTVRA 779 >tr|C1RL61|C1RL61_9CELL Tax_Id=446466 SubName: Full=Methionine synthase (B12-independent); EC=2.1.1.14;[Cellulomonas flavigena DSM 20109] Length = 783 Score = 721 bits (1860), Expect = 0.0 Identities = 398/772 (51%), Positives = 494/772 (63%), Gaps = 21/772 (2%) Query: 7 TQSFTA-TVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGL-- 63 T +F A +V G PRIGPRRELK+A E +WA RTS E+E+VA+ LRR + LA GL Sbjct: 11 TPAFPAGSVLGYPRIGPRRELKKALEAFWAGRTSADEVEAVAADLRRRTRTRLAELGLAT 70 Query: 64 DSVPV-NTFSYYDQMLDTAFMLGALPARVAQVSD-----DLDQYFALARGNNDIKPLEMT 117 D+ + + FS+YDQ+LD ++GA+P R A + D DL Y +ARG D PLEMT Sbjct: 71 DAAAIPSAFSFYDQVLDATALVGAVPERFADLQDADGRLDLAGYSTVARGRGDDLPLEMT 130 Query: 118 KWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGIN- 176 KWFDTNYHYLVPEI P TTF + + E EAL + +RPV++GPVT+L L+K Sbjct: 131 KWFDTNYHYLVPEIGPGTTFRYASDRPVAEFTEALADGVLTRPVVVGPVTYLALAKPTED 190 Query: 177 --GGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTD-LSPDAPALAEAVYTAL 233 G +P+ RL++++ +Y LL+ LA GA WVQ DEPALV D + A LAEA A Sbjct: 191 APAGFSPLDRLDDILPVYVRLLTELAAAGATWVQLDEPALVADTVGVPAEVLAEATARAY 250 Query: 234 GSVS------KRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGK 287 ++ RPAI +A +G+ GA+L +A T +E + +D V G D V LAGK Sbjct: 251 RVLATELARPSRPAILLAAPYGDLGAALPVVAATDVEGVALDLVRG-DVPSVPVAGLAGK 309 Query: 288 TLVAGIVDGRNIWRTDLESALSKLATLLGXXXXXXXXXXXXXL-HVPYSLEPETDLDDNL 346 T+V G++DG NIWR DLE L+ L L L HVP++LE E LD L Sbjct: 310 TVVGGVIDGHNIWRADLEQKLALLEQLGALGAAAVAVGTSTSLFHVPHTLEDEPALDRTL 369 Query: 347 RSWLAFGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSI 406 WLAF GR P + +VR R+ ++ Sbjct: 370 VDWLAFADEKVREVATLAEGLTAGRDAISEQLAAASQAVASRATAPGVVRPEVRERVAAL 429 Query: 407 VASGTHRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISR 466 RG A+R+ +Q ARL LP LPTTTIGS+PQT IRKARAA E+ +Y Sbjct: 430 TDEQFRRGPFAERKAAQAARLGLPALPTTTIGSFPQTPEIRKARAAFGKGELTAEQYEDE 489 Query: 467 MKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPP 526 MK EV ++LQEQ+GLDVLVHGEPERNDMVQYFAE L GF TQNGWVQSYGSRC RP Sbjct: 490 MKAEVRRVVELQEQIGLDVLVHGEPERNDMVQYFAENLDGFSVTQNGWVQSYGSRCTRPS 549 Query: 527 ILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALA 586 IL+GDVSRP P+T+ W YAQSLT KP+KGMLTGPVTILAWSFVRDDQPL DTANQVALA Sbjct: 550 ILWGDVSRPAPITVAWAQYAQSLTSKPMKGMLTGPVTILAWSFVRDDQPLGDTANQVALA 609 Query: 587 IRDETVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHT 646 +RDE DL++AGI I+QV YL W+V++FRL+T+GV TQIHT Sbjct: 610 LRDEIADLEAAGIGIVQVDEPAIRELLPLREKDHAAYLDWSVRSFRLSTAGVRPETQIHT 669 Query: 647 HLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPS 706 HLCYSEFGE++ AI LDADVTSIEAARS ME+L D+ A G+ ++GPGVYDIHSPRVPS Sbjct: 670 HLCYSEFGEIMEAIDGLDADVTSIEAARSKMEILGDIAAAGYPRAVGPGVYDIHSPRVPS 729 Query: 707 TDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 DE+ + L A++ I + +LWVNPDCGLKTR +EV+ SL+++V A R VRA Sbjct: 730 QDEVTELLTEAVRTIDVDQLWVNPDCGLKTRRYEEVTPSLEHLVTATRTVRA 781 >tr|C9KAH6|C9KAH6_9MICO Tax_Id=446469 SubName: Full=Methionine synthase (B12-independent); EC=2.1.1.14;[Sanguibacter keddieii DSM 10542] Length = 785 Score = 709 bits (1830), Expect = 0.0 Identities = 395/764 (51%), Positives = 478/764 (62%), Gaps = 20/764 (2%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLD----SVP 67 AT+ G PRIGPRRELK+A E +WA R +LE A+ LR+ L A GL SVP Sbjct: 22 ATILGYPRIGPRRELKKAVESFWAGRIDADQLEETAAALRKSTRDRLVALGLSATDGSVP 81 Query: 68 VNTFSYYDQMLDTAFMLGALPARVAQVSD-DLDQYFALARGNNDIKPLEMTKWFDTNYHY 126 TFSYYDQ+LD A +GA+P R A D DL YF ARG D PLEMTKWFDTNYHY Sbjct: 82 -ETFSYYDQVLDAAVTVGAVPERFATEGDLDLAGYFRAARGEGDDAPLEMTKWFDTNYHY 140 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGIN---GGGAPIQ 183 LVPEI P+TTF L +++ + EAL + +RPV++GPVTFLLLSK + G P+ Sbjct: 141 LVPEIGPSTTFRLASDRVVRQFAEALADGVTTRPVLVGPVTFLLLSKAADDAPAGFEPLS 200 Query: 184 RLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAP------ALAEAVYTALGSVS 237 RL +L+ +Y LL LA GA WVQ DEP LVTD + D P A+ EA ++ Sbjct: 201 RLADLLPVYAELLRALAAAGATWVQLDEPGLVTD-TIDVPLGDVLTAVTEAYRVLSTELA 259 Query: 238 K--RPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVD 295 + RPAI +A FG+ +L +A T +EA+ VD V G+ + V L KTLV G+VD Sbjct: 260 RPERPAILLAAPFGDLQEALPVVAGTDVEALAVDLVKGS-APTSPVRGLESKTLVGGVVD 318 Query: 296 GRNIWRTDLESALSKLATLLGXXXXXXXXXXXXXL-HVPYSLEPETDLDDNLRSWLAFGX 354 G NIWR DL + L L L G L HVP+ + E LD L SWLAF Sbjct: 319 GHNIWRADLSARLEVLEALEGLGAGAVAVGTSTSLQHVPHDVADEPALDPTLASWLAFAD 378 Query: 355 XXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRG 414 +GR + VR R ++ HRG Sbjct: 379 QKVAEVVTLAEGLREGREAVHEQLLAASAAVSSRATAAGVSVAAVRERTAALTDGDFHRG 438 Query: 415 DAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADA 474 A +RR +Q RL LP LP+TTIGS+PQT IRKARAA E+ Y M+ E+ Sbjct: 439 PAQERRDAQQERLDLPLLPSTTIGSFPQTVEIRKARAAHAKGELSLEAYEDAMRAEIQQV 498 Query: 475 IKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSR 534 ++LQE++G+DVLVHGE ERNDMVQYFAE L GF TQNGWVQSYGSRC RP IL+GDVSR Sbjct: 499 VELQERIGIDVLVHGEAERNDMVQYFAELLDGFAVTQNGWVQSYGSRCTRPSILWGDVSR 558 Query: 535 PHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDL 594 P PMT+ W Y QSLT KPVKGMLTGPVTI+AWSFVRDD PL +TANQ+ LA+RDE DL Sbjct: 559 PAPMTVRWTEYTQSLTTKPVKGMLTGPVTIMAWSFVRDDIPLGETANQIGLALRDEIADL 618 Query: 595 QSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFG 654 ++AGIAIIQV Q YL W+V +F L+T+GV TQIHTHLCYSEFG Sbjct: 619 EAAGIAIIQVDEPALRELLPLRRADQPAYLDWSVGSFTLSTAGVRPDTQIHTHLCYSEFG 678 Query: 655 EVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSL 714 EVIGAI LDADVTSIEAARS ME+L DLNA GF+ +GPGVYDIHSPRVPS +E+ + L Sbjct: 679 EVIGAIDALDADVTSIEAARSRMEILPDLNASGFSRGVGPGVYDIHSPRVPSQEEVTELL 738 Query: 715 RAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 A+K++ LWVNPDCGLKTR E + SL+++V AA+ VR+ Sbjct: 739 ELAVKSVDPALLWVNPDCGLKTRGYAETTPSLEHLVGAAKAVRS 782 >tr|A0LVN5|A0LVN5_ACIC1 Tax_Id=351607 SubName: Full=Methionine synthase (B12-independent); EC=2.1.1.14;[Acidothermus cellulolyticus] Length = 784 Score = 709 bits (1829), Expect = 0.0 Identities = 384/762 (50%), Positives = 469/762 (61%), Gaps = 15/762 (1%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTF 71 +TV G PR GP R+LK+ TE YWA R + LRR W +L AG+D +P N F Sbjct: 18 STVYGYPRQGPGRQLKKLTEAYWAGRLDADAFLAQTRELRRARWIELRDAGIDEIPSNDF 77 Query: 72 SYYDQMLDTAFMLGALPARVAQVSDD--------LDQYFALARGNNDIKPLEMTKWFDTN 123 SYYD +LDTA MLGALP R A D LD+YFALARGN+D PLEMTKWF TN Sbjct: 78 SYYDHVLDTAVMLGALPRRHAPALADAGQSPAARLDRYFALARGNDDAAPLEMTKWFTTN 137 Query: 124 YHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSK---GINGGGA 180 YHYLVPE+ P F L+P K L E +EA E + +RPVI+GPV+FLLLSK G+ G Sbjct: 138 YHYLVPELRPDMEFRLDPTKPLSEFREARELGLTTRPVILGPVSFLLLSKREPGVPGDFQ 197 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRP 240 P+ L +++ Y L+ L + GA WVQFDEP LV D Y L + RP Sbjct: 198 PLSLLGKIICPYLELIRRLFDAGAEWVQFDEPCLVADQPAQVLDAVATAYATLCAEEFRP 257 Query: 241 AIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSV---AAVPELAGKTLVAGIVDGR 297 + VATYF G +L LA +P++ I +D A ++ AA+ + K LVAG+VDGR Sbjct: 258 RLLVATYFDRLGDALPVLADSPVDGIAMDITGPARANIDDLAAIGGIPTKRLVAGVVDGR 317 Query: 298 NIWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXX 357 N+WRTDL +ALS L TLLG LHVP S+E E LD + WLAF Sbjct: 318 NVWRTDLAAALSTLGTLLGLAGQVDVSASCSLLHVPLSIEFERQLDPQIAGWLAFARQKL 377 Query: 358 XXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARI-DSIVASGTHRGDA 416 DG P + VR R ++ T R Sbjct: 378 EEIVILTRGLNDGWEAVAGDLQVSAARRATRLASPIVQVDAVRRRAAEAAGLPRTRRSPY 437 Query: 417 AQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIK 476 A+RR Q +L LP LPTTTIGS+PQT A+R ARA L+ E+D A Y + ++ E+A I Sbjct: 438 AERRIVQRRQLGLPALPTTTIGSFPQTPALRAARAKLRAGELDAAGYEALIEAEIAAVIA 497 Query: 477 LQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPH 536 QE GLDVLVHGEPERNDMVQYFAEQL GF T GWVQSYG+R VRPPI+ GDV+R Sbjct: 498 EQEAAGLDVLVHGEPERNDMVQYFAEQLDGFLTTAEGWVQSYGTRYVRPPIVVGDVARRG 557 Query: 537 PMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQS 596 PMT+ W TYA T KPVKGMLTGPVT+LAWSFVRDD P A+ A QVALA+RDE +DL++ Sbjct: 558 PMTVRWATYAAGRTQKPVKGMLTGPVTMLAWSFVRDDLPRAEVARQVALALRDEVLDLEA 617 Query: 597 AGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEV 656 AG+ +IQ+ + EYL WAV AFRL TSGV D TQIHTH+CY+EFG++ Sbjct: 618 AGLRVIQIDEPALRESLPLRNADRAEYLSWAVDAFRLVTSGVRDETQIHTHMCYAEFGDI 677 Query: 657 IGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRA 716 + A+ D+DADV S+EAARS M ++ DL G+ N IGPGV+D+HSPR+P+ EI + Sbjct: 678 LQALIDMDADVISLEAARSDMAIVTDLARAGYPNDIGPGVWDVHSPRIPTVQEIVDRIHL 737 Query: 717 ALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 ALK P RLW+NPDCGLKTR EV +L NMVAAAR VRA Sbjct: 738 ALKECPADRLWINPDCGLKTRGYAEVRPALANMVAAARAVRA 779 >sp|A7HQP6|METE_PARL1 Tax_Id=402881 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Parvibaculum lavamentivorans] Length = 763 Score = 670 bits (1728), Expect = 0.0 Identities = 370/759 (48%), Positives = 463/759 (61%), Gaps = 12/759 (1%) Query: 9 SFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPV 68 + T+T+ G PR+GP RELK A E YW + + L A +LRR W G+ +P Sbjct: 2 TLTSTL-GYPRVGPHRELKAALETYW-RDGEEAPLLDTAKSLRRASWRLQKEHGIGHIPS 59 Query: 69 NTFSYYDQMLDTAFMLGALPARVAQVSD-DLDQYFALARG----NNDIKPLEMTKWFDTN 123 N F+ YD +LDT M GA+P R A ++ DL YFA+ARG D+ +EMTKWFDTN Sbjct: 60 NDFTLYDHVLDTICMTGAVPERFAAGAEIDLATYFAMARGAQDGTRDVAAMEMTKWFDTN 119 Query: 124 YHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQ 183 YHY+VPE P T F L K + E EA + +RPV++GP +FL L K G P+ Sbjct: 120 YHYIVPEFSPETNFRLAFTKAIDEFAEAKALGVHTRPVLVGPFSFLKLGKATVAGFDPLD 179 Query: 184 RLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIY 243 + L+ +Y +L LAE GA WVQ DEP LV +L A A Y+AL + + + Sbjct: 180 LMGRLLPVYENVLKRLAEAGADWVQIDEPCLVLELGSGDLAKCRAAYSALSAAAPSLKLM 239 Query: 244 VATYFGN-PGASLAGLARTPIEAIGVDFVCGADTSVAAVPELA-GKTLVAGIVDGRNIWR 301 VATYFG P ASL P+ I +D V G AA+ L K L G+VDGRNIWR Sbjct: 240 VATYFGALPEASLETAMALPVAGIHLDMVRGRSQYEAALSALPRDKLLSLGLVDGRNIWR 299 Query: 302 TDLESALS--KLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXX 359 TD+E+AL+ + A L LHVP+SL E LD L+SWLAF Sbjct: 300 TDMEAALTLAERAVLTLGPKRVMISAACSLLHVPFSLAGEKSLDPELKSWLAFAEEKLGE 359 Query: 360 XXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDA-AQ 418 +GR PR+HN VRAR+ I RG A Sbjct: 360 LAVLARGVKEGRTSISTELAENAALFEARRNSPRIHNPAVRARVRDIDPHADRRGRPFAD 419 Query: 419 RRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQ 478 R++ Q R LP LPTTTIGS+PQTS +RKARA+L+ + +EA+Y + MK E+ I+LQ Sbjct: 420 RQSIQQKRFGLPKLPTTTIGSFPQTSDVRKARASLRRGDWNEAQYDAFMKAEIEKTIRLQ 479 Query: 479 EQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPM 538 E++GLDVLVHGEPER DMV+YF E+L GF T GWVQSYGSRCV+PPI++GDVSRP PM Sbjct: 480 ERIGLDVLVHGEPERTDMVEYFGEKLEGFAFTSLGWVQSYGSRCVKPPIIFGDVSRPEPM 539 Query: 539 TIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAG 598 T+EW YAQSLTD+PVKGMLTGPVTIL WSFVRDDQP ++T Q+ALAIRDE DL++AG Sbjct: 540 TVEWSRYAQSLTDRPVKGMLTGPVTILQWSFVRDDQPRSETCRQIALAIRDEVYDLEAAG 599 Query: 599 IAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIG 658 + +IQ+ D YL WA + FRL+ D TQIHTH+CYSEF ++I Sbjct: 600 LGMIQIDEPALREGLPLHRSEWDTYLRWACECFRLSVCVARDETQIHTHMCYSEFNDIIE 659 Query: 659 AIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAAL 718 AIADLDADV SIE +RS ME+LD + N IGPGVYDIHSPRVP+ E+ LR A Sbjct: 660 AIADLDADVISIETSRSRMELLDAFVDFSYPNDIGPGVYDIHSPRVPARGEMLSLLRLAA 719 Query: 719 KAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 + +P +R+WVNPDCGLKTR E A+L MV AAR++R Sbjct: 720 ERLPSERIWVNPDCGLKTRGWPETEAALVEMVEAARELR 758 >tr|C7QYL6|C7QYL6_JONDD Tax_Id=471856 SubName: Full=5-methyltetrahydropteroyltriglutamate/ homocysteine S-methyltransferase; EC=2.1.1.14;[Jonesia denitrificans] Length = 777 Score = 666 bits (1718), Expect = 0.0 Identities = 377/768 (49%), Positives = 466/768 (60%), Gaps = 26/768 (3%) Query: 11 TATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGL---DSVP 67 +AT+ G PRIG RR+LKRA E WA R++ E + LR LAA GL DS Sbjct: 10 SATILGYPRIGDRRQLKRALESLWAGRSNADEFAATTHQLRAATRERLAARGLGRDDSSI 69 Query: 68 VNTFSYYDQMLDTAFMLGALPARVAQVS---DDLDQYFALARGNNDIKPLEMTKWFDTNY 124 +FS+YDQ+LD A G +P R + D + Y +ARG D PLEMTKWF+TNY Sbjct: 70 PESFSWYDQVLDAAVTFGVIPDRFRSLDWSGDLVGAYSTVARGVGDDAPLEMTKWFNTNY 129 Query: 125 HYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGING---GGAP 181 HYLVPE++ +T F LNP + + EA Q +RP I+GPVTFL LSK G P Sbjct: 130 HYLVPEVDESTPFVLNPTLVTSLVDEARAQGFVTRPTIVGPVTFLALSKAATSASTGFDP 189 Query: 182 IQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTD-LSPDAPALAEA---VYTALGSVS 237 + RL+ELVG+Y LL++L E G +WVQ DEPALV++ LS DA AL +A Y L S Sbjct: 190 LSRLDELVGVYVELLAVLVERGVQWVQLDEPALVSENLSVDATALEQAFVAAYARLTSAD 249 Query: 238 KRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGR 297 RP I V F + GA + + +EA+ VD V G AAVP+ G TLVAG+V+GR Sbjct: 250 ARPNILVTAPFASLGALAEPVLNSGVEAVAVDLVHG--DLPAAVPD--GVTLVAGVVNGR 305 Query: 298 NIWRTDLESALSKLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXX 357 N+WR DL+ A L + HVP+++ E LD L SWLAF Sbjct: 306 NVWRCDLDQARRVLEGVHAGSVAVSTSTSLQ--HVPHTVADEPTLDPTLASWLAFADEKI 363 Query: 358 XXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGT------ 411 G P + VR R+ I + Sbjct: 364 SEVVTLARGLTQGWDAVASELDDARTVLAARAAAPGVTVPHVRERVAGITHADLARTTID 423 Query: 412 -HRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKE 470 R A R Q RL LPPLPTTTIGS+PQT+ IR+ARA ++ +A+Y +M+ E Sbjct: 424 GKRASIASRVAQQQERLQLPPLPTTTIGSFPQTADIRRARAQWTRGDLTDADYQVQMRTE 483 Query: 471 VADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYG 530 + I+LQE LGLDVLVHGE ERNDMVQYFAE L GF T+NGWVQSYGSRC RP I +G Sbjct: 484 IERVIRLQEDLGLDVLVHGEAERNDMVQYFAEHLDGFVVTENGWVQSYGSRCTRPSIQWG 543 Query: 531 DVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDE 590 DVSRP P+T +W TYAQSLT KPVKGMLTGPVTI+AWSF+R+D PLA+TA Q+ LA+RDE Sbjct: 544 DVSRPAPITTQWATYAQSLTPKPVKGMLTGPVTIMAWSFIREDLPLAETAKQIGLALRDE 603 Query: 591 TVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCY 650 DL++A IA+IQV +YL W+V +FRLAT+GV TQIHTHLCY Sbjct: 604 VGDLEAANIAVIQVDEPALRELLPLKKADHKDYLDWSVSSFRLATTGVRPDTQIHTHLCY 663 Query: 651 SEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEI 710 SEF ++I AI L ADVTSIEAARS MEVL L GF +GPG+YDIHSPRVPS +E+ Sbjct: 664 SEFNDIIDAIDHLGADVTSIEAARSRMEVLGALAVSGFGRGVGPGIYDIHSPRVPSVEEL 723 Query: 711 AKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 A+ L A++++ + LWVNPDCGLKTR DE ASL+N+V AA VRA Sbjct: 724 AELLDLAVRSVRPELLWVNPDCGLKTRGYDETVASLRNLVQAAHDVRA 771 >tr|A7BDK3|A7BDK3_9ACTO Tax_Id=411466 SubName: Full=Putative uncharacterized protein;[Actinomyces odontolyticus ATCC 17982] Length = 773 Score = 665 bits (1717), Expect = 0.0 Identities = 375/767 (48%), Positives = 472/767 (61%), Gaps = 18/767 (2%) Query: 6 TTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGL-- 63 TTQ TAT+ PRIG RELKRA E +WA R + +EL A+ LR++ + L GL Sbjct: 5 TTQFPTATILAYPRIGRGRELKRALEAHWAGRITEAELIQAANDLRKENLARLVELGLNP 64 Query: 64 -DSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDT 122 D+ + S YDQ+LD +LGA+P R A + LD YFALARG++++ P EMTKWFDT Sbjct: 65 SDASLADAPSLYDQVLDATILLGAIPPRFAG-REGLDLYFALARGDDNVGPEEMTKWFDT 123 Query: 123 NYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKG--INGGGA 180 NYHYLVPEI P T I +A E +RPV++GPVT+L L+K Sbjct: 124 NYHYLVPEIGPDTPLRFADDTITRRFTDAREWGYVTRPVLVGPVTYLALAKADPATPDFD 183 Query: 181 PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTD----LSPDAPALAEAVYTALGSV 236 P+ R++E V Y L+ L GA WVQ DEPAL +D + LA VY L + Sbjct: 184 PLTRIDEAVAAYEEALASLHAAGAPWVQLDEPALTSDNLSRTRVELGELAARVYERLAAS 243 Query: 237 SKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDG 296 RP I + T +G+ ++ LA+T +EA+ VD + GA A +L+G TLV G VDG Sbjct: 244 QNRPQILLTTPYGDASHAVGALAKTGVEALHVDTLRGALPKGA---DLSGVTLVVGAVDG 300 Query: 297 RNIWRTDLESALSKLATLLGXXXXXXXXXXXXXL-HVPYSLEPET----DLDDNLRSWLA 351 R IWR DL L L HVP+ ET L++NL +WLA Sbjct: 301 RYIWRADLAQLRETLKAAQALGAAHVTVATSNSLQHVPHDTALETWDDATLNENLHAWLA 360 Query: 352 FGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGT 411 F +G P + +VR+R ++ + Sbjct: 361 FADQKVLEVVTLARGVDEGWEAIDAEVAEATRVLEQRAAAPGVVRPEVRSRTAALTDADR 420 Query: 412 HRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEV 471 R +R +Q RLHLPPLPTTTIGS+PQT+ IRKARAA E+ +A+Y +RM++E+ Sbjct: 421 AREPYLEREAAQTERLHLPPLPTTTIGSFPQTTEIRKARAANARGELSDADYEARMREEI 480 Query: 472 ADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGD 531 A I LQE+LGLD+LVHGE ERNDMVQYFAE L GF AT+NGWVQSYGSRC RP +L+GD Sbjct: 481 ASVITLQEELGLDMLVHGEAERNDMVQYFAELLDGFAATRNGWVQSYGSRCTRPSVLWGD 540 Query: 532 VSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDET 591 VSRP PMT+ W +YAQSLTDKPVKGMLTGPVTI+AWSF R+D PL + A+Q+ LA+RDE Sbjct: 541 VSRPAPMTVGWTSYAQSLTDKPVKGMLTGPVTIIAWSFPRNDLPLGEIADQIGLALRDEV 600 Query: 592 VDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYS 651 DL++AGIA IQV +YL W+V +FRLATS V TQIHTHLCYS Sbjct: 601 SDLEAAGIAAIQVDEPALRELLPLDADRHADYLNWSVGSFRLATSSVRPDTQIHTHLCYS 660 Query: 652 EFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIA 711 EFG++I AI LDADVTSIEAARS MEV+ +L GF + IGPGV+DIH+PRVP T+E+A Sbjct: 661 EFGQIIDAIKGLDADVTSIEAARSKMEVVPELAEAGFDHGIGPGVWDIHAPRVPGTEELA 720 Query: 712 KSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 + + A A+P+ RLWVNPDCGLKTR E ASL N+V+A RQVRA Sbjct: 721 ELIGLAADAVPVSRLWVNPDCGLKTRGYVETKASLDNLVSATRQVRA 767 >tr|A4BR72|A4BR72_9GAMM Tax_Id=314278 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14;[Nitrococcus mobilis Nb-231] Length = 773 Score = 664 bits (1714), Expect = 0.0 Identities = 370/761 (48%), Positives = 461/761 (60%), Gaps = 16/761 (2%) Query: 11 TATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNT 70 T G PRIG RRELKRA + YW + L LR W+ A AGLD VPV Sbjct: 12 TTHALGFPRIGARRELKRALDAYWRGEIDQDTLRRTGVELRSRHWALQAEAGLDLVPVGD 71 Query: 71 FSYYDQMLDTAFMLGALPAR----VAQVSDDLDQYFALARGN----NDIKPLEMTKWFDT 122 FSYYD +LDT+ +LG +P R V + DLD+YF +ARG D+ EMTKWFDT Sbjct: 72 FSYYDHVLDTSALLGVIPERFGREVGEDGIDLDRYFRMARGRAPRGEDVTACEMTKWFDT 131 Query: 123 NYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPI 182 NYHY+VPE+ F+L+ + +L EA + + S+PV+IGP+T+L LSK + + Sbjct: 132 NYHYIVPELAHDQRFTLHARGLEAQLDEAHAKGLRSKPVLIGPLTYLWLSKVRDEPFDKL 191 Query: 183 QRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAI 242 LE L+ IY LL LA G WVQ DEP LV DL A +A Y L + P + Sbjct: 192 TLLERLLPIYAELLHRLAGRGIEWVQMDEPILVCDLDAAWQAAFKAAYQQLAA-QHHPRL 250 Query: 243 YVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAG-KTLVAGIVDGRNIWR 301 + TYFG GA+L + P+ + VD V + +P L K L AG++DGRNIWR Sbjct: 251 LLTTYFGGLGANLEWALQLPVGGVHVDLVRAPEQLSEILPRLTEEKVLSAGVIDGRNIWR 310 Query: 302 TDLESALSKLATL---LGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXX 358 TDLE+ L L LG LHVP L ET LDD L++WLAFG Sbjct: 311 TDLEAWLEPLGRAQEQLGERLWLAPSCSL--LHVPVDLAGETRLDDELKNWLAFGVQKLE 368 Query: 359 XXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDA-A 417 +GR R+HN V+ R+ ++ + + R + Sbjct: 369 EVALLGRALREGRASIAQALEANRAALAARRESSRIHNAAVQQRLRAVSPTMSRRASPYS 428 Query: 418 QRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKL 477 QR Q ARL LP LPTTTIGS+PQT AIR AR + ++ A Y RM+ E+ IK Sbjct: 429 QRAPLQRARLKLPLLPTTTIGSFPQTQAIRAARRDYRAGRLERAAYEQRMRAEIEHTIKT 488 Query: 478 QEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHP 537 QE LGLD+LVHGEPERNDMV+YF E L GF +TQ GWVQS+GSRCV+PPI+YGDV R P Sbjct: 489 QEALGLDMLVHGEPERNDMVEYFGELLEGFASTQQGWVQSFGSRCVKPPIIYGDVRRAGP 548 Query: 538 MTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSA 597 MT+EWI YAQSLT++PVKGMLTGPVTIL WSFVRDDQP A T Q+ALA+R E DL++A Sbjct: 549 MTVEWIRYAQSLTERPVKGMLTGPVTILQWSFVRDDQPRAATCQQIALALRGEVGDLEAA 608 Query: 598 GIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVI 657 GI IQV + YL WAV+AFRLAT+GV D TQIH+H+CYSEF ++I Sbjct: 609 GIRAIQVDEPALREGLPLRGSERPAYLDWAVRAFRLATAGVRDETQIHSHMCYSEFNDII 668 Query: 658 GAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAA 717 AIA+LDADV +IEAARS ME+L + N IGPGVYDIHSPRVPS E+A+ L A Sbjct: 669 QAIAELDADVITIEAARSDMELLAAFAEFEYPNEIGPGVYDIHSPRVPSVAEMAQQLEKA 728 Query: 718 LKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 + I Q+LW NPDCGLKTR+ +E +L NM+AAA+++RA Sbjct: 729 AEVITRQQLWANPDCGLKTRAWEESKPALANMIAAAQELRA 769 >tr|C8WU41|C8WU41_ALIAD Tax_Id=521098 SubName: Full=5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; EC=2.1.1.14;[Alicyclobacillus acidocaldarius subsp. acidocaldarius] Length = 762 Score = 663 bits (1711), Expect = 0.0 Identities = 362/756 (47%), Positives = 462/756 (61%), Gaps = 8/756 (1%) Query: 9 SFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPV 68 + TA++ G PR+GPRRELKR E +W + EL + A+ LR+ W G++ + Sbjct: 2 AITASI-GFPRMGPRRELKRMVEQFWQGKIGEDELTARAAELRKLRWQVQRDRGVEWIVA 60 Query: 69 NTFSYYDQMLDTAFMLGALPARV-AQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHYL 127 N FS+YD +LD A + A+P R A S L QYFA+ARG D LEMTKWFDTNYHYL Sbjct: 61 NDFSFYDHVLDAACLFQAVPERFRALPSGSLQQYFAMARGTQDATALEMTKWFDTNYHYL 120 Query: 128 VPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLEE 187 VPE+EP F+L K L E EA + P ++GP+TFL LSK + G P+ L Sbjct: 121 VPELEPKQVFTLGVNKPLNEYLEAKALGFDTVPQLVGPITFLKLSKVVGGDVDPLSLLPN 180 Query: 188 LVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVATY 247 L+ Y + L E GA WVQ DEPALV DL+ Y AL VS RP I VATY Sbjct: 181 LIPAYEAWFASLREAGAAWVQLDEPALVLDLTDAERQAFVDAYAALAKVS-RPNILVATY 239 Query: 248 FGNPGASLAGLARTPIEAIGVDFVCGADT--SVAAVPELAGKTLVAGIVDGRNIWRTDLE 305 FG+ G +LA P+E + +D V G D V A+ G+ L G++DGRN+WR DL+ Sbjct: 240 FGSLGDNLATALELPVEGLHLDLVRGPDALQQVHALGWPKGRRLSLGVIDGRNVWRADLD 299 Query: 306 SALSKL--ATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXX 363 +A + L L LHVP+ +E E+D+D ++SWLAF Sbjct: 300 TAFAHLEQGVHLTGAEHVMIAPSCSLLHVPWDVELESDMDPEIKSWLAFALQKLDEIALL 359 Query: 364 XXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDA-AQRRTS 422 +GR RL+ VRAR+D + R A R+ Sbjct: 360 KRALDEGRAAVEAQLEANRALLASRRASARLNREDVRARLDEVKTWKLDRQSPHAVRKEK 419 Query: 423 QDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLG 482 Q +R LP LPTTTIGS+PQT A+R ARA + E EY + ++ E+ I +QE++G Sbjct: 420 QASRFKLPLLPTTTIGSFPQTQAVRDARAKWRKGEWTTDEYEAYLRSEIRRWIDIQEEIG 479 Query: 483 LDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEW 542 LDVLVHGE ER DMV+YF E L GF T++GWVQSYGSRCV+PPI+YGDV+RP PMT+ W Sbjct: 480 LDVLVHGEFERTDMVEYFGEMLDGFVFTKHGWVQSYGSRCVKPPIIYGDVARPAPMTVRW 539 Query: 543 ITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAII 602 TYAQSLT+KPVKGMLTGPVTIL WSFVRDD P A+T Q+ALAIRDE +DL++AGI +I Sbjct: 540 STYAQSLTEKPVKGMLTGPVTILQWSFVRDDIPRAETCRQIALAIRDEVLDLEAAGIGMI 599 Query: 603 QVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIAD 662 Q+ + YL WAV+ FR+A+SGV D TQIHTH+CY+EF +++ AI Sbjct: 600 QIDEPALREGLPLRRADWEAYLGWAVECFRIASSGVRDETQIHTHMCYAEFNDIMPAIQA 659 Query: 663 LDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIP 722 +DADV SIE +RSHME+L + N IGPGVYDIHSPRVPS DE+ + LR A I Sbjct: 660 MDADVISIETSRSHMELLKAFEHFRYENDIGPGVYDIHSPRVPSVDEMVELLRKAASVIR 719 Query: 723 MQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 ++LWVNPDCGLKTR E A+L+NMV AA+++RA Sbjct: 720 PEQLWVNPDCGLKTRGEPETVAALRNMVDAAQRMRA 755 >sp|Q9AAW1|METE_CAUCR Tax_Id=155892 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Caulobacter crescentus] Length = 777 Score = 654 bits (1687), Expect = 0.0 Identities = 361/773 (46%), Positives = 456/773 (58%), Gaps = 25/773 (3%) Query: 11 TATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNT 70 T G PRIGP+RELK A E YWA +T L A LR W+ AA G+ VP N Sbjct: 4 TIATLGFPRIGPKRELKFALEAYWAGKTDADALLDTARDLRAKTWTRQAALGVAHVPSND 63 Query: 71 FSYYDQMLDTAFMLGALPARVAQVSD--DLDQYFALARGN-------------------N 109 FS YD +LDTA M+GA+PA DL YFA+ARG+ + Sbjct: 64 FSLYDHVLDTAVMVGAIPAAYGWSGGTVDLATYFAMARGDQGRPAAEACGPGCGHAPGAD 123 Query: 110 DIKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFL 169 + LEMTKWFDTNYHYL PE+ P F+L K + E EA + +RPV++GPVTFL Sbjct: 124 GVPALEMTKWFDTNYHYLAPELSPGQAFALTSSKPVDEFLEAKALGVHTRPVLLGPVTFL 183 Query: 170 LLSKGINGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAV 229 L+K G +P+ L L+ +Y +L LA GA WVQ DEP L DL+ A Sbjct: 184 KLAKTKAEGFSPLSLLSALLPVYGQVLRGLAAAGADWVQIDEPCLALDLTDFERAELRRA 243 Query: 230 YTALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTL 289 Y AL + + + +YFG G +LA P+E + +D V D AA+ + Sbjct: 244 YGALTHAAPGVRLMLTSYFGGYGENLATAVNLPVEGLHLDLVRAPDELEAALAASRESLV 303 Query: 290 VA-GIVDGRNIWRTDLESALSKLATLLGXXXXXXXXXXXXX--LHVPYSLEPETDLDDNL 346 ++ G++DGRN+WR DL + L +L ++ LH P L+ ET LD + Sbjct: 304 LSLGVIDGRNVWRADLPALLDRLEPVVARRGSDRVVLAPSCSLLHTPIDLDLETALDPEI 363 Query: 347 RSWLAFGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSI 406 R WLAF GR PR+H+ +V R+ ++ Sbjct: 364 RQWLAFAVQKVEALAVLAQALNGGRASVAAALEASAQAARARATSPRIHDPKVAERLAAV 423 Query: 407 VASGTHRGDAA-QRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYIS 465 T R QRR +Q ARL+LPPLPTTTIGS+PQT+ +R+ARAA +I +A Y + Sbjct: 424 TPDMTRRRSPYDQRREAQRARLNLPPLPTTTIGSFPQTTEVRQARAAFAKGQISDATYEA 483 Query: 466 RMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRP 525 +++E A A+ QE +GLDVLVHGE ERNDMVQYF EQL GF TQ+GWVQSYGSRCVRP Sbjct: 484 FLRQETARAVAWQETVGLDVLVHGEFERNDMVQYFGEQLAGFAFTQSGWVQSYGSRCVRP 543 Query: 526 PILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVAL 585 PIL+GDVSRP PMT++W YAQ LT +P+KGMLTGPVTIL WSFVRDD P Q+AL Sbjct: 544 PILFGDVSRPAPMTVDWWRYAQGLTRRPMKGMLTGPVTILNWSFVRDDLPRETACRQIAL 603 Query: 586 AIRDETVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIH 645 AIRDE VDL++ G AIIQ+ D YL WAV++FRLA SGVAD+TQIH Sbjct: 604 AIRDEVVDLEATGAAIIQIDEAALREGLPLRRGDWDAYLDWAVESFRLAASGVADATQIH 663 Query: 646 THLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVP 705 TH+CYSEF ++I AI +DADV SIE ARS ME+LD + IGPGVYDIHSPRVP Sbjct: 664 THMCYSEFNDIIAAIGAMDADVISIETARSKMELLDAFVGYAYPAQIGPGVYDIHSPRVP 723 Query: 706 STDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 + +E+ L AA + + ++LWVNPDCGLKTR E A++ NMV AAR+ RA Sbjct: 724 AVEEMTTLLAAARQRLAGEQLWVNPDCGLKTRKWPETQAAIVNMVEAARRARA 776 >tr|B8GZU6|B8GZU6_CAUCN Tax_Id=565050 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14;[Caulobacter crescentus] Length = 777 Score = 654 bits (1687), Expect = 0.0 Identities = 361/773 (46%), Positives = 456/773 (58%), Gaps = 25/773 (3%) Query: 11 TATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNT 70 T G PRIGP+RELK A E YWA +T L A LR W+ AA G+ VP N Sbjct: 4 TIATLGFPRIGPKRELKFALEAYWAGKTDADALLDTARDLRAKTWTRQAALGVAHVPSND 63 Query: 71 FSYYDQMLDTAFMLGALPARVAQVSD--DLDQYFALARGN-------------------N 109 FS YD +LDTA M+GA+PA DL YFA+ARG+ + Sbjct: 64 FSLYDHVLDTAVMVGAIPAAYGWSGGTVDLATYFAMARGDQGRPAAEACGPGCGHAPGAD 123 Query: 110 DIKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFL 169 + LEMTKWFDTNYHYL PE+ P F+L K + E EA + +RPV++GPVTFL Sbjct: 124 GVPALEMTKWFDTNYHYLAPELSPGQAFALTSSKPVDEFLEAKALGVHTRPVLLGPVTFL 183 Query: 170 LLSKGINGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAV 229 L+K G +P+ L L+ +Y +L LA GA WVQ DEP L DL+ A Sbjct: 184 KLAKTKAEGFSPLSLLSALLPVYGQVLRGLAAAGADWVQIDEPCLALDLTDFERAELRRA 243 Query: 230 YTALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTL 289 Y AL + + + +YFG G +LA P+E + +D V D AA+ + Sbjct: 244 YGALTHAAPGVRLMLTSYFGGYGENLATAVNLPVEGLHLDLVRAPDELEAALAASRESLV 303 Query: 290 VA-GIVDGRNIWRTDLESALSKLATLLGXXXXXXXXXXXXX--LHVPYSLEPETDLDDNL 346 ++ G++DGRN+WR DL + L +L ++ LH P L+ ET LD + Sbjct: 304 LSLGVIDGRNVWRADLPALLDRLEPVVARRGSDRVVLAPSCSLLHTPIDLDLETALDPEI 363 Query: 347 RSWLAFGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSI 406 R WLAF GR PR+H+ +V R+ ++ Sbjct: 364 RQWLAFAVQKVEALAVLAQALNGGRASVAAALEASAQAARARATSPRIHDPKVAERLAAV 423 Query: 407 VASGTHRGDAA-QRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYIS 465 T R QRR +Q ARL+LPPLPTTTIGS+PQT+ +R+ARAA +I +A Y + Sbjct: 424 TPDMTRRRSPYDQRREAQRARLNLPPLPTTTIGSFPQTTEVRQARAAFAKGQISDATYEA 483 Query: 466 RMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRP 525 +++E A A+ QE +GLDVLVHGE ERNDMVQYF EQL GF TQ+GWVQSYGSRCVRP Sbjct: 484 FLRQETARAVAWQETVGLDVLVHGEFERNDMVQYFGEQLAGFAFTQSGWVQSYGSRCVRP 543 Query: 526 PILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVAL 585 PIL+GDVSRP PMT++W YAQ LT +P+KGMLTGPVTIL WSFVRDD P Q+AL Sbjct: 544 PILFGDVSRPAPMTVDWWRYAQGLTRRPMKGMLTGPVTILNWSFVRDDLPRETACRQIAL 603 Query: 586 AIRDETVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIH 645 AIRDE VDL++ G AIIQ+ D YL WAV++FRLA SGVAD+TQIH Sbjct: 604 AIRDEVVDLEATGAAIIQIDEAALREGLPLRRGDWDAYLDWAVESFRLAASGVADATQIH 663 Query: 646 THLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVP 705 TH+CYSEF ++I AI +DADV SIE ARS ME+LD + IGPGVYDIHSPRVP Sbjct: 664 THMCYSEFNDIIAAIGAMDADVISIETARSKMELLDAFVGYAYPAQIGPGVYDIHSPRVP 723 Query: 706 STDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 + +E+ L AA + + ++LWVNPDCGLKTR E A++ NMV AAR+ RA Sbjct: 724 AVEEMTTLLAAARQRLAGEQLWVNPDCGLKTRKWPETQAAIVNMVEAARRARA 776 >tr|C0W5C4|C0W5C4_9ACTO Tax_Id=525246 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14;[Actinomyces urogenitalis DSM 15434] Length = 805 Score = 651 bits (1680), Expect = 0.0 Identities = 369/789 (46%), Positives = 478/789 (60%), Gaps = 36/789 (4%) Query: 3 ELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAG 62 ++ TT AT+ G PRIG RELKRA E YW T + L A +LR+ S L G Sbjct: 18 QIPTTPLPPATILGYPRIGADRELKRAVESYWKGATDLAALRRSARSLRKATRSHLRELG 77 Query: 63 L---DSVPVNTFSYYDQMLDTAFMLGALPARVAQVSD---------DLDQYFALARGNND 110 L +VP + F+YYDQ+L GALP R A + DL YF ARG + Sbjct: 78 LTGPSAVPAD-FAYYDQVLQVTTAFGALPTRFADLGGSAGEGYPGTDLPGYFTAARGQGE 136 Query: 111 IKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKIL-----GELKEALE-----QRIPSRP 160 LEMTKW D+NYHYLVPE++ T PG G + LE + +P RP Sbjct: 137 CAALEMTKWLDSNYHYLVPELDEHTPLDYVPGFAAVDPTDGPGAQVLEAERAGEEVP-RP 195 Query: 161 VIIGPVTFLLLSKGINGGGA---PIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTD 217 V++GPVT+LLL+K + G P+ RL +L+ Y LL L GA+WVQ DEPALV+D Sbjct: 196 VVVGPVTYLLLAKASDEAGPDFHPLDRLPDLLAAYGHLLGDLWAAGAQWVQLDEPALVSD 255 Query: 218 LSPDAPA-----LAEAVYTALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVC 272 + D P A YT +G++++RP + VA +G+ G +L LA T IE + +D V Sbjct: 256 -AWDVPRQQVLEAVRAAYTWIGAIAERPQVLVAGTYGSLGDALPVLAATEIEGVALDLVA 314 Query: 273 GADTSVAAVPELAGKTLVAGIVDGRNIWRTDLESALSKLATL---LGXXXXXXXXXXXXX 329 G + + L GK++VAG+V GRN+WRTDLE+AL L L L Sbjct: 315 GQRPTAQELGSLGGKSVVAGVVSGRNVWRTDLEAALELLEGLRRDLPEDAPLVVGTSTSL 374 Query: 330 LHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXX 389 HVP+ E ET L ++RSWLAF G+ Sbjct: 375 QHVPHDAERETSLPADVRSWLAFADQKVAEVGVLARALAQGQQAVAQELALDARLREERA 434 Query: 390 XXPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKA 449 P ++ +VR+ ++ A+ R A+R+ Q ARL LP LPTTTIGS+PQT+ IR A Sbjct: 435 THPGVNRAEVRSAAGAVSAADRQRSPYAERQKVQAARLRLPLLPTTTIGSFPQTAQIRTA 494 Query: 450 RAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFA 509 RAA + E+D + Y M++E+A ++LQE++GLDVLVHGE ERNDMVQYFAE L GF Sbjct: 495 RAAWRRGELDHSGYEQAMRQEIARVVELQEEIGLDVLVHGEAERNDMVQYFAELLDGFVT 554 Query: 510 TQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSF 569 T++GWVQSYGSRC RP IL+GDVSRP PMT+ W +YAQSLTDKP+KGMLTGPVTI+AWSF Sbjct: 555 TEHGWVQSYGSRCTRPSILWGDVSRPAPMTVAWSSYAQSLTDKPLKGMLTGPVTIMAWSF 614 Query: 570 VRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVK 629 VRDD P A A+Q+ LA+R+E DL++AGI +IQV + +YL W+V Sbjct: 615 VRDDVPRALVADQLGLALREEVADLEAAGIPVIQVDEPAIRETLPLRRAERADYLKWSVG 674 Query: 630 AFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFA 689 AFRLAT G +TQIHTHLCYSEF VI A+ LDADVTSIEA+RS M++L + GF Sbjct: 675 AFRLATGGAGAATQIHTHLCYSEFDVVIDAVDHLDADVTSIEASRSRMDILPAVAEHGFE 734 Query: 690 NSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNM 749 +GPGV+DIHSPRVPS DE + L A+ A+ +++LW NPDCGLKTR +E ASL+++ Sbjct: 735 RQLGPGVWDIHSPRVPSVDECEELLERAVAALGIEQLWANPDCGLKTRGYEETVASLRHL 794 Query: 750 VAAARQVRA 758 V AA++VRA Sbjct: 795 VEAAQRVRA 803 >sp|Q87BY8|METE_XYLFT Tax_Id=183190 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Xylella fastidiosa] Length = 758 Score = 651 bits (1679), Expect = 0.0 Identities = 357/756 (47%), Positives = 461/756 (60%), Gaps = 13/756 (1%) Query: 13 TVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTFS 72 T G PRIG RRELKRA E +W T ++L+ A LR W AG+D P N FS Sbjct: 5 TNLGFPRIGARRELKRALESHWRGETDATQLQHTARELRARHWRLQRDAGVDLPPSNDFS 64 Query: 73 YYDQMLDTAFMLGALPARVAQV--SDDLDQYFALARG----NNDIKPLEMTKWFDTNYHY 126 YD +LDTAF+ A+P R + +D L YFA+ARG N D+ LEMTKWFDTNYHY Sbjct: 65 LYDHVLDTAFLFDAIPQRYRGLVDADPLAGYFAMARGRQADNIDLHALEMTKWFDTNYHY 124 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPE+ F+L K + E +EAL I +RPV++GPV+FLLLSK ++G + LE Sbjct: 125 LVPELHRDQHFALRGNKPIAEFEEALALGITTRPVLLGPVSFLLLSKTVDGSNR-LDLLE 183 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 L+ +Y LL L E+GA WVQ DEP LV DL Y L RP + + + Sbjct: 184 RLLPVYTQLLRQLQESGAEWVQIDEPTLVLDLDAQTQQAFRKAYAILNQ-GPRPKLLLTS 242 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPEL-AGKTLVAGIVDGRNIWRTDLE 305 YFG G +L + P + + +D V G + A + L AG+ L AG+V+GRNIWRTDL+ Sbjct: 243 YFGPLGDNLELALQLPADGLHIDLVRGTEQLDAVLNTLPAGRVLSAGLVNGRNIWRTDLD 302 Query: 306 SALSKLATLLGXXXXXXXXXXXXX--LHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXX 363 +AL+ G LHVP LE E +LD ++R+WLAF Sbjct: 303 NALTMARYAQGHVGADRLWLAPSCSLLHVPVDLEQEKNLDADVRNWLAFAKQKLSELRVL 362 Query: 364 XXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDA-AQRRTS 422 D + P++H V R+ ++ T R A QR + Sbjct: 363 ADAL-DNKPEAETALTQTRQALEARRQSPKVHRPDVAQRLAALTPDTTRRNTAYPQRSQA 421 Query: 423 QDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLG 482 Q L+LP PTTTIGS+PQT +R+ARA + ++ E++Y + +K E ++ QE++G Sbjct: 422 QQHTLNLPAYPTTTIGSFPQTLEVREARAQFKSGKLSESDYEAFLKAETERCVRTQEEIG 481 Query: 483 LDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEW 542 LDVLVHGE ERNDMV+YF EQL GF T+ GWVQSYGSRCV+PPI+YGDV RP PMT+ W Sbjct: 482 LDVLVHGEFERNDMVEYFGEQLDGFIFTKLGWVQSYGSRCVKPPIIYGDVVRPAPMTVTW 541 Query: 543 ITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAII 602 YAQSLTDKP+KGMLTGPVT+L WSFVRDDQ A T Q+ALA+RDE DL+ AGI +I Sbjct: 542 SAYAQSLTDKPMKGMLTGPVTMLQWSFVRDDQERAQTCRQIALALRDEVQDLEKAGIKVI 601 Query: 603 QVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIAD 662 Q+ +YL WAV++FR+A+S V D+TQIHTH+CYSEF ++I A+A Sbjct: 602 QIDEPAIREGLPLRRGEWADYLNWAVESFRIASSNVHDTTQIHTHMCYSEFNDIIEAVAA 661 Query: 663 LDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIP 722 LDADV SIE +RS ME+LD + N+IGPGVYDIHSPRVP +E+ L+ A +P Sbjct: 662 LDADVISIETSRSRMELLDAFVKFRYPNAIGPGVYDIHSPRVPQEEEMVLLLKKARAVLP 721 Query: 723 MQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 ++LWVNPDCGLKTR E A+LQ MV AA+++RA Sbjct: 722 PEQLWVNPDCGLKTRGWKETRAALQTMVHAAQRLRA 757 >sp|B2I621|METE_XYLF2 Tax_Id=405441 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Xylella fastidiosa] Length = 758 Score = 651 bits (1679), Expect = 0.0 Identities = 357/756 (47%), Positives = 461/756 (60%), Gaps = 13/756 (1%) Query: 13 TVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTFS 72 T G PRIG RRELKRA E +W T ++L+ A LR W AG+D P N FS Sbjct: 5 TNLGFPRIGARRELKRALESHWRGETDATQLQHTARELRARHWRLQRDAGVDLPPSNDFS 64 Query: 73 YYDQMLDTAFMLGALPARVAQV--SDDLDQYFALARG----NNDIKPLEMTKWFDTNYHY 126 YD +LDTAF+ A+P R + +D L YFA+ARG N D+ LEMTKWFDTNYHY Sbjct: 65 LYDHVLDTAFLFDAIPQRYRGLVDADPLAGYFAMARGRQADNIDLHALEMTKWFDTNYHY 124 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPE+ F+L K + E +EAL I +RPV++GPV+FLLLSK ++G + LE Sbjct: 125 LVPELHRDQHFALRGNKPIAEFEEALALGITTRPVLLGPVSFLLLSKTVDGSNR-LDLLE 183 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVAT 246 L+ +Y LL L E+GA WVQ DEP LV DL Y L RP + + + Sbjct: 184 RLLPVYTQLLRQLQESGAEWVQIDEPTLVLDLDAQTQQAFRKAYAILNQ-GPRPKLLLTS 242 Query: 247 YFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPEL-AGKTLVAGIVDGRNIWRTDLE 305 YFG G +L + P + + +D V G + A + L AG+ L AG+V+GRNIWRTDL+ Sbjct: 243 YFGPLGDNLELALQLPADGLHIDLVRGTEQLDAVLNTLPAGRVLSAGLVNGRNIWRTDLD 302 Query: 306 SALSKLATLLGXXXXXXXXXXXXX--LHVPYSLEPETDLDDNLRSWLAFGXXXXXXXXXX 363 +AL+ G LHVP LE E +LD ++R+WLAF Sbjct: 303 NALTMARYAQGHVGADRLWLAPSCSLLHVPVDLEQEKNLDADVRNWLAFAKQKLSELRVL 362 Query: 364 XXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDA-AQRRTS 422 D + P++H V R+ ++ T R A QR + Sbjct: 363 ADAL-DNKPEAETALTQTRQALEARRQSPKVHRPDVAQRLAALTPDTTRRNTAYPQRSQA 421 Query: 423 QDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLG 482 Q L+LP PTTTIGS+PQT +R+ARA + ++ E++Y + +K E ++ QE++G Sbjct: 422 QQHTLNLPAYPTTTIGSFPQTLEVREARAQFKSGKLSESDYEAFLKAETERCVRTQEEIG 481 Query: 483 LDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEW 542 LDVLVHGE ERNDMV+YF EQL GF T+ GWVQSYGSRCV+PPI+YGDV RP PMT+ W Sbjct: 482 LDVLVHGEFERNDMVEYFGEQLDGFIFTKLGWVQSYGSRCVKPPIIYGDVVRPAPMTVTW 541 Query: 543 ITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAII 602 YAQSLTDKP+KGMLTGPVT+L WSFVRDDQ A T Q+ALA+RDE DL+ AGI +I Sbjct: 542 SAYAQSLTDKPMKGMLTGPVTMLQWSFVRDDQERAQTCRQIALALRDEVQDLEKAGIKVI 601 Query: 603 QVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIAD 662 Q+ +YL WAV++FR+A+S V D+TQIHTH+CYSEF ++I A+A Sbjct: 602 QIDEPAIREGLPLRRGEWADYLNWAVESFRIASSNVHDTTQIHTHMCYSEFNDIIEAVAA 661 Query: 663 LDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIP 722 LDADV SIE +RS ME+LD + N+IGPGVYDIHSPRVP +E+ L+ A +P Sbjct: 662 LDADVISIETSRSRMELLDAFVKFRYPNAIGPGVYDIHSPRVPQEEEMVLLLKKARAVLP 721 Query: 723 MQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 ++LWVNPDCGLKTR E A+LQ MV AA+++RA Sbjct: 722 PEQLWVNPDCGLKTRGWKETRAALQTMVHAAQRLRA 757 >tr|D0MEA5|D0MEA5_RHOMR Tax_Id=518766 SubName: Full=5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase;[Rhodothermus marinus DSM 4252] Length = 774 Score = 651 bits (1679), Expect = 0.0 Identities = 364/765 (47%), Positives = 458/765 (59%), Gaps = 19/765 (2%) Query: 12 ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTF 71 AT G PRIG RELK A EGYWA R S +EL A LR W AGLD +P N F Sbjct: 4 ATNLGFPRIGLARELKWAVEGYWAGRVSENELLETARRLRARHWQWQQEAGLDQIPSNDF 63 Query: 72 SYYDQMLDTAFMLGALPARVAQVSD--DLDQYFALARGNND------------IKPLEMT 117 S YD +LDT ++GA+P R D DL YFA+ARG + + PLEMT Sbjct: 64 SLYDHVLDTIALVGAVPERFGWRGDSVDLATYFAMARGVQEKELEARGLEGTGVPPLEMT 123 Query: 118 KWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGING 177 KWFDTNYHYLVPE P F L K + E EA I +RPV++GPV+FLLL + Sbjct: 124 KWFDTNYHYLVPEFHPEQRFRLASTKPIDEYLEAKALGIETRPVLLGPVSFLLLGRATVT 183 Query: 178 GGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVS 237 P+ L+ L+ +Y +L L GAR+VQ DEP LV DL P A + Y AL S Sbjct: 184 HFDPLTLLDRLLPVYAEVLRRLKAAGARYVQMDEPCLVRDLPPGARQAYQQAYAAL-SRP 242 Query: 238 KRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELA-GKTLVAGIVDG 296 + PA+ + TYFG +L P+ A+ +D V + A+ L + L G+VDG Sbjct: 243 EHPALVLTTYFGGLEENLPLARSLPVAAVHLDLVRAPEQLEPALAHLPEDRILSLGLVDG 302 Query: 297 RNIWRTDLESALSKLATLLGXXXXXXXXXXXXX--LHVPYSLEPETDLDDNLRSWLAFGX 354 RN+WRTDL+ A S L + LHVP L+ E +LD +R WLAF Sbjct: 303 RNVWRTDLDVAASMLRRAVDALGRERVWIGPSCSLLHVPIDLDAEAELDPEIRPWLAFAR 362 Query: 355 XXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRG 414 +G PR + +V+ R+ ++ + T RG Sbjct: 363 QKLDELVTLKRLINEGEAAAGDRLETARRARQERLTSPRRIDPEVQRRLAALSSEMTRRG 422 Query: 415 DA-AQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVAD 473 A+R Q ARL LP LPTTTIGS+PQT +R+ RAA + E+ Y ++ +A+ Sbjct: 423 RPFAERYALQRARLKLPLLPTTTIGSFPQTDELRRKRAAFRRGELSREVYEQFLEATIAE 482 Query: 474 AIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVS 533 I QE +GLDVLVHGEPER+DMV+YFAEQL GF T+NGWVQSYG+RCVRPPILYGDV+ Sbjct: 483 TIARQEAIGLDVLVHGEPERSDMVEYFAEQLQGFLVTRNGWVQSYGTRCVRPPILYGDVA 542 Query: 534 RPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVD 593 R PMT+ W T+AQ T +PVKG+LTGPVTIL WSFVRDDQP ADT Q+ALA+RDE D Sbjct: 543 RRGPMTVRWTTFAQRCTARPVKGILTGPVTILQWSFVRDDQPRADTCRQIALALRDEVAD 602 Query: 594 LQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEF 653 L++AGI++IQ+ YL WAV+ FRLA+ V D TQIHTH+CY++F Sbjct: 603 LEAAGISVIQIDEPALREGLPLRRRDWPAYLEWAVECFRLASCVVRDETQIHTHMCYADF 662 Query: 654 GEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKS 713 +++ AIA LDADV SIEAARS M +LD + N+IGPGVYDIHSPRVPS +EI Sbjct: 663 EDILEAIAALDADVISIEAARSRMALLDAFRRFRYPNAIGPGVYDIHSPRVPSVEEIEAL 722 Query: 714 LRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 L+ AL+ IP +RLWVNPDCGLKTR EV +L++MV AAR++RA Sbjct: 723 LKRALEVIPAERLWVNPDCGLKTRRWAEVEPALRHMVEAARRLRA 767 >tr|C1DC47|C1DC47_LARHH Tax_Id=557598 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; EC=2.1.1.14;[Laribacter hongkongensis] Length = 766 Score = 649 bits (1674), Expect = 0.0 Identities = 362/764 (47%), Positives = 455/764 (59%), Gaps = 22/764 (2%) Query: 11 TATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNT 70 T G PRIG +RELK A E YW R+S +ELE+V + LR+ W A + LD VPV Sbjct: 3 TVHTLGFPRIGAKRELKFALESYWQGRSSLAELENVGAGLRQRHWQ--AQSALDWVPVGD 60 Query: 71 FSYYDQMLDTAFMLGALPARVAQVSD-DLDQYFALARGNN-------------DIKPLEM 116 FS+YDQ+LD F LG LP RV +LD YF LARG + + EM Sbjct: 61 FSFYDQVLDMTFTLGNLPKRVQGFHGAELDNYFRLARGRSASASGDAHAGCCAGVAAGEM 120 Query: 117 TKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGIN 176 TKWFDTNYHY+VPE TTFSLN G++L +L EA + ++PVIIGPVT+L + K Sbjct: 121 TKWFDTNYHYIVPEFTAGTTFSLNAGRLLAQLDEARRLGVKAKPVIIGPVTYLAIGKS-K 179 Query: 177 GGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSV 236 G A + LE L+ +Y LL LLA +GA WVQ DEP LVT+L D Y L S Sbjct: 180 DGSARLDLLERLLPVYAELLDLLAAHGAEWVQIDEPLLVTELEADWQQAFNTAYHHLKSC 239 Query: 237 SKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELA-GKTLVAGIVD 295 R + +ATYFG + A P+ + VD V G D + + L K + G+V+ Sbjct: 240 --RVKLLLATYFGALHENKYLAANLPVAGLHVDAVSGRDDVLPLLNLLPLHKVVSLGVVN 297 Query: 296 GRNIWRTDLESALSKLATLL-GXXXXXXXXXXXXXLHVPYSLEPETDLDDNLRSWLAFGX 354 GRN+W+TDL + L L L LHVP L+ E LD +RSWLAF Sbjct: 298 GRNVWKTDLNATLDWLEPLARNLGPRLWIAPSCSLLHVPVDLDSEEKLDAEVRSWLAFAV 357 Query: 355 XXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVAS-GTHR 413 GR PR+H V+A + +I G Sbjct: 358 QKLDELAVLAGALRHGRASVQAELDANRAAIEARRQSPRVHAPAVKAALAAISPELGQRH 417 Query: 414 GDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVAD 473 A+R Q L LP PTTTIGS+PQT+AIR+AR+ + +DE+ Y + M+ E+A Sbjct: 418 SPYAERAARQAGHLQLPLFPTTTIGSFPQTAAIRQARSDYKAGRLDESGYKAAMQAEIAH 477 Query: 474 AIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVS 533 A++ QE L LDVLVHGE ERNDMV+YF EQL G+ +Q GWVQSYGSRCV+PPIL+GD+ Sbjct: 478 AVREQEALQLDVLVHGEAERNDMVEYFGEQLEGYVFSQAGWVQSYGSRCVKPPILFGDIR 537 Query: 534 RPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVD 593 RP MT+EWITYAQSLTDKPVKGMLTGPVTIL WSFVRDDQP A T Q+ALAIR+E +D Sbjct: 538 RPQAMTVEWITYAQSLTDKPVKGMLTGPVTILNWSFVRDDQPRAVTCRQLALAIREEVLD 597 Query: 594 LQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEF 653 L+ AG+ IIQ+ YL WAV+ FR+ +GVAD+TQIHTH+CYSEF Sbjct: 598 LERAGVRIIQIDEAALREGLPLRRSQWQGYLAWAVECFRITANGVADTTQIHTHMCYSEF 657 Query: 654 GEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKS 713 ++I AIA +DADV +IE +RS ME+LD + N IGPGVYDIHSP +P+ + Sbjct: 658 NDIIAAIAAMDADVITIETSRSDMELLDVFEHFRYPNQIGPGVYDIHSPNIPTVGHMVGL 717 Query: 714 LRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757 + A + +P +RLWVNPDCGLKTR +EV +L NMV AR +R Sbjct: 718 MNKAAEHVPAERLWVNPDCGLKTRQWNEVLPALANMVETARVLR 761 >tr|A9AM89|A9AM89_BURM1 Tax_Id=395019 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase;[Burkholderia multivorans] Length = 777 Score = 648 bits (1672), Expect = 0.0 Identities = 362/776 (46%), Positives = 466/776 (60%), Gaps = 36/776 (4%) Query: 4 LVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGL 63 +VTT + G PRIG +RELK E YW +SR EL ++ + LRR W+D GL Sbjct: 14 MVTTHNL-----GFPRIGAKRELKFGLERYWNGESSRDELTALGAALRRQHWND--QRGL 66 Query: 64 DSVPVNTFSYYDQMLDTAFMLGALPARVAQV-SDDLDQYFALARGNN------------D 110 D VP+ F++YDQ+LD +F LG LP RV D LD YF +ARG + Sbjct: 67 DLVPIGDFAFYDQVLDMSFTLGNLPKRVRDFHGDPLDNYFRVARGRSAQSADAHAACCGG 126 Query: 111 IKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLL 170 + EMTKWFDTNYHY+VPE T FSL+P ++L L EA + ++PVI+GPVT+L Sbjct: 127 VAAGEMTKWFDTNYHYIVPEFHGDTNFSLDPSRLLQHLAEARAAGVTAKPVILGPVTYLW 186 Query: 171 LSKGINGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVY 230 L K + + L +L+ +Y LL L G WVQ DEP LVT+L + Y Sbjct: 187 LGKSKDDSDR-LALLPKLLPVYGALLDTLTAQGVEWVQVDEPILVTELDAEWRHALRTAY 245 Query: 231 TALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPEL-AGKTL 289 AL + +R + +ATYFG +L A P++ + VD + D A V EL A + L Sbjct: 246 AALET--RRIKLLLATYFGELQDNLTLAASLPVDGLHVDAINARDEIAAVVRELPADRVL 303 Query: 290 VAGIVDGRNIWRTDLESALS---KLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNL 346 G ++GRNIW+TDL + L LA LG LHVP L E LD ++ Sbjct: 304 SVGAINGRNIWKTDLNATLDWLEPLAKQLGDRLWLAPSCSL--LHVPVDLASEDRLDADI 361 Query: 347 RSWLAFGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSI 406 RSWLAF +GR PR+HN V+ D+I Sbjct: 362 RSWLAFALQKLDELKVLATALNEGRDKVADALAANAAAIDSRRRSPRVHNPAVK---DAI 418 Query: 407 VASGTHRGDAA----QRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAE 462 GD A QR Q ARL+LP PTTTIGS+PQT+ IR AR+ + +DEA Sbjct: 419 ARIDARLGDRASPYPQRAAKQAARLNLPAFPTTTIGSFPQTAEIRHARSRFKAGTLDEAG 478 Query: 463 YISRMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRC 522 Y + M+ E+ +++ QE L LDVLVHGE ERNDMV+YF EQL GF ++ GWVQSYGSRC Sbjct: 479 YRAAMRAEIERSVREQESLELDVLVHGEAERNDMVEYFGEQLDGFAFSRFGWVQSYGSRC 538 Query: 523 VRPPILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQ 582 V+PPIL+GD+SRP+ MT+EWITYAQSLT KP+KGMLTGPVTIL WSFVRDDQP + + Q Sbjct: 539 VKPPILFGDISRPNAMTVEWITYAQSLTHKPMKGMLTGPVTILNWSFVRDDQPRSVSCRQ 598 Query: 583 VALAIRDETVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADST 642 +ALAIRDE +DL+ AG+ +IQ+ YL WAV++FR+A +GV D T Sbjct: 599 LALAIRDEVLDLEKAGVRVIQIDEAALREGLPLRRSQWSAYLQWAVESFRIAANGVRDDT 658 Query: 643 QIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSP 702 QIHTH+CYSEF ++I +IAD+DADV +IE +RS ME+LD ++ + N IGPGVYDIHSP Sbjct: 659 QIHTHMCYSEFNDIIASIADMDADVITIETSRSDMELLDAFDSFRYPNEIGPGVYDIHSP 718 Query: 703 RVPSTDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 +P+ D I ++ A + IP RLWVNPDCGLKTR EV +L NMVAAA+ +RA Sbjct: 719 NIPTQDHIVALMKKAAERIPADRLWVNPDCGLKTRRWAEVIPALANMVAAAKTLRA 774 >tr|B3D9R9|B3D9R9_BURM1 Tax_Id=395019 (metE)SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; EC=2.1.1.14;[Burkholderia multivorans] Length = 764 Score = 648 bits (1672), Expect = 0.0 Identities = 362/776 (46%), Positives = 466/776 (60%), Gaps = 36/776 (4%) Query: 4 LVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGL 63 +VTT + G PRIG +RELK E YW +SR EL ++ + LRR W+D GL Sbjct: 1 MVTTHNL-----GFPRIGAKRELKFGLERYWNGESSRDELTALGAALRRQHWND--QRGL 53 Query: 64 DSVPVNTFSYYDQMLDTAFMLGALPARVAQV-SDDLDQYFALARGNN------------D 110 D VP+ F++YDQ+LD +F LG LP RV D LD YF +ARG + Sbjct: 54 DLVPIGDFAFYDQVLDMSFTLGNLPKRVRDFHGDPLDNYFRVARGRSAQSADAHAACCGG 113 Query: 111 IKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLL 170 + EMTKWFDTNYHY+VPE T FSL+P ++L L EA + ++PVI+GPVT+L Sbjct: 114 VAAGEMTKWFDTNYHYIVPEFHGDTNFSLDPSRLLQHLAEARAAGVTAKPVILGPVTYLW 173 Query: 171 LSKGINGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVY 230 L K + + L +L+ +Y LL L G WVQ DEP LVT+L + Y Sbjct: 174 LGKSKDDSDR-LALLPKLLPVYGALLDTLTAQGVEWVQVDEPILVTELDAEWRHALRTAY 232 Query: 231 TALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPEL-AGKTL 289 AL + +R + +ATYFG +L A P++ + VD + D A V EL A + L Sbjct: 233 AALET--RRIKLLLATYFGELQDNLTLAASLPVDGLHVDAINARDEIAAVVRELPADRVL 290 Query: 290 VAGIVDGRNIWRTDLESALS---KLATLLGXXXXXXXXXXXXXLHVPYSLEPETDLDDNL 346 G ++GRNIW+TDL + L LA LG LHVP L E LD ++ Sbjct: 291 SVGAINGRNIWKTDLNATLDWLEPLAKQLGDRLWLAPSCSL--LHVPVDLASEDRLDADI 348 Query: 347 RSWLAFGXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSI 406 RSWLAF +GR PR+HN V+ D+I Sbjct: 349 RSWLAFALQKLDELKVLATALNEGRDKVADALAANAAAIDSRRRSPRVHNPAVK---DAI 405 Query: 407 VASGTHRGDAA----QRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAE 462 GD A QR Q ARL+LP PTTTIGS+PQT+ IR AR+ + +DEA Sbjct: 406 ARIDARLGDRASPYPQRAAKQAARLNLPAFPTTTIGSFPQTAEIRHARSRFKAGTLDEAG 465 Query: 463 YISRMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRC 522 Y + M+ E+ +++ QE L LDVLVHGE ERNDMV+YF EQL GF ++ GWVQSYGSRC Sbjct: 466 YRAAMRAEIERSVREQESLELDVLVHGEAERNDMVEYFGEQLDGFAFSRFGWVQSYGSRC 525 Query: 523 VRPPILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQ 582 V+PPIL+GD+SRP+ MT+EWITYAQSLT KP+KGMLTGPVTIL WSFVRDDQP + + Q Sbjct: 526 VKPPILFGDISRPNAMTVEWITYAQSLTHKPMKGMLTGPVTILNWSFVRDDQPRSVSCRQ 585 Query: 583 VALAIRDETVDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADST 642 +ALAIRDE +DL+ AG+ +IQ+ YL WAV++FR+A +GV D T Sbjct: 586 LALAIRDEVLDLEKAGVRVIQIDEAALREGLPLRRSQWSAYLQWAVESFRIAANGVRDDT 645 Query: 643 QIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSP 702 QIHTH+CYSEF ++I +IAD+DADV +IE +RS ME+LD ++ + N IGPGVYDIHSP Sbjct: 646 QIHTHMCYSEFNDIIASIADMDADVITIETSRSDMELLDAFDSFRYPNEIGPGVYDIHSP 705 Query: 703 RVPSTDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 +P+ D I ++ A + IP RLWVNPDCGLKTR EV +L NMVAAA+ +RA Sbjct: 706 NIPTQDHIVALMKKAAERIPADRLWVNPDCGLKTRRWAEVIPALANMVAAAKTLRA 761 >sp|Q8XS05|METE_RALSO Tax_Id=305 (metE)RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase;[Ralstonia solanacearum] Length = 776 Score = 648 bits (1671), Expect = 0.0 Identities = 360/757 (47%), Positives = 449/757 (59%), Gaps = 15/757 (1%) Query: 11 TATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNT 70 T G PRIG +RELK A E +W ++ ++L LR W+ AGLD V V Sbjct: 3 TIHTLGYPRIGAQRELKFALESFWKGASTEADLRDTGRALRERHWNAQRDAGLDFVTVGD 62 Query: 71 FSYYDQMLDTAFMLGALPARV----AQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHY 126 F++YDQ+L TA +LGALP R AQ++ L Q F LARGN D +EMTKWFDTNYHY Sbjct: 63 FAWYDQVLQTAALLGALPTRYGFDPAQLT--LAQSFVLARGNADHAAMEMTKWFDTNYHY 120 Query: 127 LVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLE 186 LVPE+ P F G + E++EA + ++GPVTFL L+K G + L Sbjct: 121 LVPELTPDLRFGPGTGWLFDEVREAQAAGHRVKVALLGPVTFLHLAKARGGLADKLSLLP 180 Query: 187 ELVGIYCTLLSLLAENGARWVQFDEPALVTDLSP---DAPALAEAVYTALGSVSKRPAIY 243 +L+ Y +L LA G WVQ DEPALV DL DA A A A G P + Sbjct: 181 QLLPAYAAVLKRLAAEGVEWVQIDEPALVLDLPQAWSDAYGPAYATLAAAGG----PRLL 236 Query: 244 VATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTD 303 +ATYF A + P+ + +D V A P A K L AG+VDGRNIWRTD Sbjct: 237 LATYFEAASHHAALIRSLPVAGVHLDLVRAPQQLEAFAPWPADKVLSAGVVDGRNIWRTD 296 Query: 304 LESALSKLATLLGXXXXXXXXXXXXXL-HVPYSLEPETDLDDNLRSWLAFGXXXXXXXXX 362 LE AL+++A L L HVP L ET LDD L+ WLAF Sbjct: 297 LEQALARVAPLAQTLGERLWLAPSCSLLHVPVDLAAETRLDDELKGWLAFARQKLDELAV 356 Query: 363 XXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTHRGDAAQ-RRT 421 DGR R+HN V+ R +I A R R Sbjct: 357 LKRAVIDGRDAAHAALAGSAAAIASRAASRRVHNDSVKKRAAAIRAQDAERAAPYPVRAA 416 Query: 422 SQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQL 481 +Q ARL+LP LPTTTIGS+PQT+ IR+ARA + E+ Y+ RM+ E+AD ++ QE L Sbjct: 417 AQQARLNLPLLPTTTIGSFPQTAEIRQARAQYKRGELQALTYLERMRAEIADVVQRQEAL 476 Query: 482 GLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIE 541 GLD+LVHGE ERNDMV+YF E L G+ T NGWVQSYGSRCV+PP++YGDV RP PMT+E Sbjct: 477 GLDMLVHGEAERNDMVEYFGELLWGYAFTANGWVQSYGSRCVKPPVIYGDVYRPEPMTVE 536 Query: 542 WITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAI 601 W YAQSLT KP+KGMLTGPVT+L WSFVRDDQP TA Q+ALA+RDE DL++AGIA Sbjct: 537 WSRYAQSLTAKPMKGMLTGPVTMLQWSFVRDDQPREQTALQIALALRDEVRDLEAAGIAA 596 Query: 602 IQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIA 661 IQ+ YL WA + FR++ SGV + TQIHTH+CYSEF +++ AIA Sbjct: 597 IQIDEPAFREGLPLRAGDVAVYLEWAARVFRVSASGVRNDTQIHTHMCYSEFNDILPAIA 656 Query: 662 DLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAI 721 +DADV +IE +RS+ME+LD + N IGPGVYDIHSPRVP +E+ L A + + Sbjct: 657 SMDADVITIETSRSNMELLDAFGEFAYPNEIGPGVYDIHSPRVPRVEEMEALLDKAAQVV 716 Query: 722 PMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 P+QRLWVNPDCGLKTR EV A+L+ MV A R++RA Sbjct: 717 PVQRLWVNPDCGLKTRGWPEVEAALRGMVEATRRLRA 753 >tr|Q3R9R9|Q3R9R9_XYLFA Tax_Id=155920 SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; EC=2.1.1.14;[Xylella fastidiosa subsp. sandyi Ann-1] Length = 802 Score = 648 bits (1671), Expect = 0.0 Identities = 358/767 (46%), Positives = 466/767 (60%), Gaps = 14/767 (1%) Query: 3 ELVTTQSFT-ATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAA 61 +++ T + T T G PRIG RRELKRA E +W T ++L+ A LR W A Sbjct: 38 QVLRTPTMTIVTNLGFPRIGARRELKRALESHWRGETDATQLQHTARELRARHWRLQRDA 97 Query: 62 GLDSVPVNTFSYYDQMLDTAFMLGALPARVAQV--SDDLDQYFALARG----NNDIKPLE 115 G+D P N FS YD +LDTAF+ A+P R + +D L YFA+ARG N D+ LE Sbjct: 98 GVDLPPSNDFSLYDHVLDTAFLFDAIPQRYHGLVDADPLAGYFAMARGRQADNIDLHALE 157 Query: 116 MTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGI 175 MTKWFDTNYHYLVPE+ F+L K + E +EAL I +RPV++GPV+FLLLSK + Sbjct: 158 MTKWFDTNYHYLVPELHRDQHFALRGNKPIAEFEEALALGITTRPVLLGPVSFLLLSKTV 217 Query: 176 NGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGS 235 +G + LE L+ +Y LL L E+GA WVQ DEP LV DL Y L Sbjct: 218 DGSNR-LDLLERLLPVYTQLLRQLQESGAEWVQIDEPTLVLDLDAQTQQAFRKAYATLNQ 276 Query: 236 VSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPEL-AGKTLVAGIV 294 RP + + +YFG G +L + P + + +D V G + A + L AG+ L AG+V Sbjct: 277 -GPRPKLLLTSYFGPLGDNLELALQLPADGLHIDLVRGTEQLDAVLNTLPAGRVLSAGLV 335 Query: 295 DGRNIWRTDLESALSKLATLLGXXXXXXXXXXXXX--LHVPYSLEPETDLDDNLRSWLAF 352 +GRNIWRT L++AL+ G LHVP LE E +LD ++R+WLAF Sbjct: 336 NGRNIWRTALDNALTLARYAQGRVDKDHLWLAPSCSLLHVPVDLEQEKNLDADVRNWLAF 395 Query: 353 GXXXXXXXXXXXXXXXDGRXXXXXXXXXXXXXXXXXXXXPRLHNGQVRARIDSIVASGTH 412 D + P++H V R+ ++ T Sbjct: 396 AKQKLSELRVLADAL-DNKPEAETALTQTRQALEARRQSPKVHRPDVAQRLAALTPDTTR 454 Query: 413 RGDA-AQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEV 471 R A QR +Q L+LP PTTTIGS+PQT +R+ARA + ++ E++Y + +K E Sbjct: 455 RNTAYPQRSQAQQHTLNLPAYPTTTIGSFPQTLEVREARAQFKSGKLSESDYEAFLKAET 514 Query: 472 ADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGD 531 ++ QE++GLDVLVHGE ERNDMV+YF EQL GF T+ GWVQSYGSRCV+PPI+YGD Sbjct: 515 ERCVRTQEEIGLDVLVHGEFERNDMVEYFGEQLDGFIFTKLGWVQSYGSRCVKPPIIYGD 574 Query: 532 VSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDET 591 V RP PMT+ W YAQSLTDKP+KGMLTGPVT+L WSFVRDDQ A T Q+ALA+RDE Sbjct: 575 VVRPAPMTVTWSAYAQSLTDKPMKGMLTGPVTMLQWSFVRDDQERAQTCRQIALALRDEV 634 Query: 592 VDLQSAGIAIIQVXXXXXXXXXXXXXXXQDEYLCWAVKAFRLATSGVADSTQIHTHLCYS 651 DL+ AGI +IQ+ +YL WAV++FR+A+S V D+TQIHTH+CYS Sbjct: 635 QDLEKAGIKVIQIDEPAIREGLPLRRGEWADYLNWAVESFRIASSNVHDTTQIHTHMCYS 694 Query: 652 EFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIA 711 EF ++I A+A LDADV SIE +RS ME+LD + N+IGPGVYDIHSPRVP +E+ Sbjct: 695 EFNDIIEAVAALDADVISIETSRSRMELLDAFVKFRYPNAIGPGVYDIHSPRVPQEEEMV 754 Query: 712 KSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRA 758 L+ A +P ++LWVNPDCGLKTR E A+LQ MV AA+++RA Sbjct: 755 LLLKKARAVLPPEQLWVNPDCGLKTRGWKETRAALQTMVHAAQRLRA 801 Database: Amellifera_nr Posted date: Jan 15, 2010 5:10 AM Number of letters in database: 3,808,957,724 Number of sequences in database: 11,153,314 Lambda K H 0.318 0.133 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11153314 Number of Hits to DB: 5,045,190,678 Number of extensions: 202224238 Number of successful extensions: 507299 Number of sequences better than 10.0: 1440 Number of HSP's gapped: 502472 Number of HSP's successfully gapped: 2169 Length of query: 760 Length of database: 3,808,957,724 Length adjustment: 145 Effective length of query: 615 Effective length of database: 2,191,727,194 Effective search space: 1347912224310 Effective search space used: 1347912224310 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 85 (37.4 bits)