BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= ML1635
         (286 letters)

Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr;
Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr;
trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr;
Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr;
Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr;
Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr;
Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr;
Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr;
Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr;
Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr;
Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr;
Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 
           11,153,314 sequences; 3,808,957,724 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits)  Value

sp|Q9CBT0|PANB_MYCLE Tax_Id=1769 (panB)RecName: Full=3-methyl-2-...   528   e-148
tr|B8ZRX9|B8ZRX9_MYCLB Tax_Id=561304 (panB)SubName: Full=3-methy...   528   e-148
sp|Q73YI6|PANB_MYCPA Tax_Id=1770 (panB)RecName: Full=3-methyl-2-...   442   e-122
sp|A0PNG6|PANB_MYCUA Tax_Id=362242 (panB)RecName: Full=3-methyl-...   441   e-122
sp|A0QEV5|PANB_MYCA1 Tax_Id=243243 (panB)RecName: Full=3-methyl-...   441   e-122
sp|B2HHM7|PANB_MYCMM Tax_Id=216594 (panB)RecName: Full=3-methyl-...   439   e-121
sp|P0A5Q8|PANB_MYCTU Tax_Id=1773 (panB)RecName: Full=3-methyl-2-...   434   e-120
sp|A1KKR8|PANB_MYCBP Tax_Id=410289 (panB)RecName: Full=3-methyl-...   434   e-120
sp|P0C2T4|PANB_MYCBO Tax_Id=1765 (panB)RecName: Full=3-methyl-2-...   434   e-120
tr|C6DPI2|C6DPI2_MYCTK Tax_Id=478434 SubName: Full=3-methyl-2-ox...   434   e-120
tr|C1AQE1|C1AQE1_MYCBT Tax_Id=561275 (panB)SubName: Full=3-methy...   434   e-120
tr|A5U4Q5|A5U4Q5_MYCTA Tax_Id=419947 (panB)SubName: Full=3-methy...   434   e-120
tr|A5WPJ6|A5WPJ6_MYCTF Tax_Id=336982 SubName: Full=3-methyl-2-ox...   434   e-120
tr|A2VJW6|A2VJW6_MYCTU Tax_Id=348776 SubName: Full=3-methyl-2-ox...   434   e-120
sp|Q1B6P5|PANB_MYCSS Tax_Id=164756 (panB)RecName: Full=3-methyl-...   414   e-114
sp|A1UID0|PANB_MYCSK Tax_Id=189918 (panB)RecName: Full=3-methyl-...   414   e-114
sp|A3Q1U4|PANB_MYCSJ Tax_Id=164757 (panB)RecName: Full=3-methyl-...   414   e-114
tr|A4TBM9|A4TBM9_MYCGI Tax_Id=350054 SubName: Full=3-methyl-2-ox...   405   e-111
tr|A0R087|A0R087_MYCS2 Tax_Id=246196 (panB)SubName: Full=3-methy...   402   e-110
sp|Q9L7B2|PANB_MYCVP Tax_Id=350058 (panB)RecName: Full=3-methyl-...   394   e-108
tr|B1MNU8|B1MNU8_MYCA9 Tax_Id=561007 SubName: Full=3-methyl-2-ox...   385   e-105
sp|Q0SHJ0|PANB_RHOSR Tax_Id=101510 (panB)RecName: Full=3-methyl-...   384   e-105
tr|C1AUD4|C1AUD4_RHOOB Tax_Id=632772 (panB)SubName: Full=3-methy...   379   e-103
sp|Q5YZ95|PANB_NOCFA Tax_Id=37329 (panB)RecName: Full=3-methyl-2...   377   e-102
tr|C1A174|C1A174_RHOE4 Tax_Id=234621 (panB)SubName: Full=3-methy...   369   e-100
tr|C3JIP0|C3JIP0_RHOER Tax_Id=596309 (panB)SubName: Full=3-methy...   369   e-100
tr|D0LB03|D0LB03_9ACTO Tax_Id=526226 SubName: Full=3-methyl-2-ox...   357   7e-97
sp|A4FA49|PANB_SACEN Tax_Id=405948 (panB)RecName: Full=3-methyl-...   332   3e-89
tr|C4RMM0|C4RMM0_9ACTO Tax_Id=219305 SubName: Full=3-methyl-2-ox...   326   2e-87
tr|C7MWE6|C7MWE6_SACVD Tax_Id=471857 SubName: Full=Ketopantoate ...   323   1e-86
tr|C0U999|C0U999_9ACTO Tax_Id=526225 SubName: Full=Ketopantoate ...   320   2e-85
sp|Q0RFD5|PANB_FRAAA Tax_Id=326424 (panB)RecName: Full=3-methyl-...   315   3e-84
tr|A8LE65|A8LE65_FRASN Tax_Id=298653 SubName: Full=3-methyl-2-ox...   313   1e-83
tr|A3TLZ3|A3TLZ3_9MICO Tax_Id=313589 SubName: Full=3-methyl-2-ox...   312   3e-83
tr|A4XA35|A4XA35_SALTO Tax_Id=369723 SubName: Full=3-methyl-2-ox...   310   1e-82
tr|A8LZ26|A8LZ26_SALAI Tax_Id=391037 SubName: Full=3-methyl-2-ox...   310   2e-82
sp|Q2J886|PANB_FRASC Tax_Id=106370 (panB)RecName: Full=3-methyl-...   308   6e-82
tr|C1YSU2|C1YSU2_NOCDA Tax_Id=446468 SubName: Full=Ketopantoate ...   306   2e-81
tr|C1WX85|C1WX85_9ACTO Tax_Id=479435 SubName: Full=3-methyl-2-ox...   302   3e-80
tr|C4EA96|C4EA96_STRRS Tax_Id=479432 SubName: Full=Ketopantoate ...   301   6e-80
tr|A6WD73|A6WD73_KINRD Tax_Id=266940 SubName: Full=3-methyl-2-ox...   298   6e-79
sp|Q6AFH4|PANB_LEIXX Tax_Id=59736 (panB)RecName: Full=3-methyl-2...   295   3e-78
tr|C4DC95|C4DC95_9ACTO Tax_Id=446470 SubName: Full=Ketopantoate ...   295   5e-78
sp|A1SIB6|PANB_NOCSJ Tax_Id=196162 (panB)RecName: Full=3-methyl-...   292   3e-77
tr|C6WMD0|C6WMD0_ACTMD Tax_Id=446462 SubName: Full=3-methyl-2-ox...   291   8e-77
sp|Q47R98|PANB_THEFY Tax_Id=269800 (panB)RecName: Full=3-methyl-...   290   2e-76
tr|C4LHZ4|C4LHZ4_CORK4 Tax_Id=645127 SubName: Full=Ketopantoate ...   290   2e-76
tr|C1DI17|C1DI17_AZOVD Tax_Id=322710 SubName: Full=3-methyl-2-ox...   289   3e-76
tr|C2ASR8|C2ASR8_TSUPA Tax_Id=521096 SubName: Full=Ketopantoate ...   289   3e-76
sp|A0JVB5|PANB_ARTS2 Tax_Id=290399 (panB)RecName: Full=3-methyl-...   287   8e-76

>sp|Q9CBT0|PANB_MYCLE Tax_Id=1769 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           leprae]
          Length = 286

 Score =  528 bits (1359), Expect = e-148
 Identities = 270/286 (94%), Positives = 270/286 (94%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI
Sbjct: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL
Sbjct: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG
Sbjct: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
           GDAEQT                MEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD
Sbjct: 181 GDAEQTVADAVAVAEAGAFSVVMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF
Sbjct: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286


>tr|B8ZRX9|B8ZRX9_MYCLB Tax_Id=561304 (panB)SubName:
           Full=3-methyl-2-oxobutanoate
           hydroxymethyltransferase;[Mycobacterium leprae]
          Length = 286

 Score =  528 bits (1359), Expect = e-148
 Identities = 270/286 (94%), Positives = 270/286 (94%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI
Sbjct: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL
Sbjct: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG
Sbjct: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
           GDAEQT                MEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD
Sbjct: 181 GDAEQTVADAVAVAEAGAFSVVMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF
Sbjct: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286


>sp|Q73YI6|PANB_MYCPA Tax_Id=1770 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           paratuberculosis]
          Length = 285

 Score =  442 bits (1137), Expect = e-122
 Identities = 232/287 (80%), Positives = 241/287 (83%), Gaps = 3/287 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQ-RTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAG 59
           MSE NV  YGA       Q  Q RT+IRT HLQKMKAEGHKWAMLTAYDYSTAR+FDEAG
Sbjct: 1   MSEHNV--YGAAQPAQPGQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAG 58

Query: 60  IPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAA 119
           IPVLLVGDSAANVVYGYDTTVPVS DEL+PLVRGVVRGA HALVVADLPFGSYE GP AA
Sbjct: 59  IPVLLVGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAA 118

Query: 120 LAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGR 179
           LA ATRFMKEGGAHAVKLEGG+RVAEQIA LTAAGIPVMAHIGFTPQSVNSLGGFRVQGR
Sbjct: 119 LAAATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGR 178

Query: 180 GGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQ 239
           G  AEQT                MEMVP ELATQITGKLTIPTIGIGAG NCD QVLVWQ
Sbjct: 179 GDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQ 238

Query: 240 DMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           DMAG+SSGK ARFVK++ADI GELRRAA QYA EVA+ VFPA+EHCF
Sbjct: 239 DMAGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF 285


>sp|A0PNG6|PANB_MYCUA Tax_Id=362242 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           ulcerans]
          Length = 297

 Score =  441 bits (1135), Expect = e-122
 Identities = 228/293 (77%), Positives = 244/293 (83%), Gaps = 7/293 (2%)

Query: 1   MSEQNV-NVYGADP------STSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTAR 53
           +SEQ+  NVYGA P      S+ S  S  RTK+RT HLQK KAEGHKWAMLT YDYSTAR
Sbjct: 5   ISEQSEQNVYGACPPVPAGESSPSAASAPRTKVRTHHLQKWKAEGHKWAMLTVYDYSTAR 64

Query: 54  VFDEAGIPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYE 113
            FD+AGIPVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE
Sbjct: 65  AFDDAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYE 124

Query: 114 PGPTAALAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGG 173
            GP+AALA ATRFMKE GAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGG
Sbjct: 125 SGPSAALAAATRFMKEAGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGG 184

Query: 174 FRVQGRGGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDA 233
           FRVQGRG  AEQT                MEMVP ELATQITGKLTIPTIGIGAG +CD 
Sbjct: 185 FRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDG 244

Query: 234 QVLVWQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           QVLVWQDMAGLSSGK  RFVK+YAD+ GELRRAA+QYA++VA  VFPAEEHCF
Sbjct: 245 QVLVWQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHCF 297


>sp|A0QEV5|PANB_MYCA1 Tax_Id=243243 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           avium]
          Length = 285

 Score =  441 bits (1133), Expect = e-122
 Identities = 231/287 (80%), Positives = 240/287 (83%), Gaps = 3/287 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQ-RTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAG 59
           MSE NV  YGA       Q  Q RT+IRT HLQKMKAEGHKWAMLTAYDYSTAR+FDEAG
Sbjct: 1   MSEHNV--YGAAQPAQPAQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAG 58

Query: 60  IPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAA 119
           IPVLLVGDSAANVVYGYDTTVPVS DEL+PLVRGVVRGA HALVVADLPFGSYE GP AA
Sbjct: 59  IPVLLVGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAA 118

Query: 120 LAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGR 179
           LA ATRFMKEGGAHAVKLEGG+RVAEQIA LTAAGIPVMAHIGFTPQSVNSLGGFRVQGR
Sbjct: 119 LAAATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGR 178

Query: 180 GGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQ 239
           G  AEQT                MEMVP  LATQITGKLTIPTIGIGAG NCD QVLVWQ
Sbjct: 179 GDAAEQTIADAIAVAEAGAFSVVMEMVPAGLATQITGKLTIPTIGIGAGPNCDGQVLVWQ 238

Query: 240 DMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           DMAG+SSGK ARFVK++ADI GELRRAA QYA EVA+ VFPA+EHCF
Sbjct: 239 DMAGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF 285


>sp|B2HHM7|PANB_MYCMM Tax_Id=216594 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           marinum]
          Length = 297

 Score =  439 bits (1130), Expect = e-121
 Identities = 227/293 (77%), Positives = 243/293 (82%), Gaps = 7/293 (2%)

Query: 1   MSEQNV-NVYGADP------STSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTAR 53
           +SEQ+  NVYGA        S+ S  S  RTK+RT HLQK KAEGHKWAMLT YDYSTAR
Sbjct: 5   ISEQSEQNVYGASSPVPAGESSPSAASAPRTKVRTHHLQKWKAEGHKWAMLTVYDYSTAR 64

Query: 54  VFDEAGIPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYE 113
            FD+AGIPVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE
Sbjct: 65  AFDDAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYE 124

Query: 114 PGPTAALAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGG 173
            GP+AALA ATRFMKE GAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGG
Sbjct: 125 SGPSAALAAATRFMKEAGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGG 184

Query: 174 FRVQGRGGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDA 233
           FRVQGRG  AEQT                MEMVP ELATQITGKLTIPTIGIGAG +CD 
Sbjct: 185 FRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDG 244

Query: 234 QVLVWQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           QVLVWQDMAGLSSGK  RFVK+YAD+ GELRRAA+QYA++VA  VFPAEEHCF
Sbjct: 245 QVLVWQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHCF 297


>sp|P0A5Q8|PANB_MYCTU Tax_Id=1773 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           tuberculosis]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>sp|A1KKR8|PANB_MYCBP Tax_Id=410289 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           bovis]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>sp|P0C2T4|PANB_MYCBO Tax_Id=1765 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           bovis]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>tr|C6DPI2|C6DPI2_MYCTK Tax_Id=478434 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase
           panB;[Mycobacterium tuberculosis]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>tr|C1AQE1|C1AQE1_MYCBT Tax_Id=561275 (panB)SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Mycobacterium bovis]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>tr|A5U4Q5|A5U4Q5_MYCTA Tax_Id=419947 (panB)SubName:
           Full=3-methyl-2-oxobutanoate
           hydroxymethyltransferase;[Mycobacterium tuberculosis]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>tr|A5WPJ6|A5WPJ6_MYCTF Tax_Id=336982 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase
           panB;[Mycobacterium tuberculosis]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>tr|A2VJW6|A2VJW6_MYCTU Tax_Id=348776 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase
           panB;[Mycobacterium tuberculosis C]
          Length = 281

 Score =  434 bits (1117), Expect = e-120
 Identities = 223/286 (77%), Positives = 239/286 (83%), Gaps = 5/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ +  YGA+    S     RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAGI
Sbjct: 1   MSEQTI--YGANTPGGSGP---RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGI 55

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAAL
Sbjct: 56  PVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAAL 115

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG
Sbjct: 116 AAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRG 175

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQD
Sbjct: 176 DAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQD 235

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG S  K ARFVK+YAD+ GELRRAAMQYA+EVA  VFPA+EH F
Sbjct: 236 MAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281


>sp|Q1B6P5|PANB_MYCSS Tax_Id=164756 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           sp.]
          Length = 282

 Score =  414 bits (1064), Expect = e-114
 Identities = 212/286 (74%), Positives = 232/286 (81%), Gaps = 4/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ V    +D  T       R K+RT HLQK KAEGHKWAMLTAYD+STAR FD+AGI
Sbjct: 1   MSEQTVYGAASDQPTPK----PRVKVRTTHLQKWKAEGHKWAMLTAYDFSTARAFDDAGI 56

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP++ DEL+PLVRGVVRGA HALVVADLPFGSYE GP  AL
Sbjct: 57  PVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPHALVVADLPFGSYEEGPRQAL 116

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+KE GAHAVKLEGG+RVAEQIA L+AAGIPVMAHIGFTPQSVN LGGF+VQGRG
Sbjct: 117 ATATRFLKETGAHAVKLEGGERVAEQIATLSAAGIPVMAHIGFTPQSVNGLGGFKVQGRG 176

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCDAQVLVWQD
Sbjct: 177 DAAEQTIHDAIAVQEAGAFSVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQD 236

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAGL+SG+ A+FVK++ D+  ELRRAA QYA+EVA+ VFPAEEH F
Sbjct: 237 MAGLTSGRTAKFVKRFGDVGAELRRAASQYADEVAAGVFPAEEHSF 282


>sp|A1UID0|PANB_MYCSK Tax_Id=189918 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           sp.]
          Length = 282

 Score =  414 bits (1064), Expect = e-114
 Identities = 212/286 (74%), Positives = 232/286 (81%), Gaps = 4/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ V    +D  T       R K+RT HLQK KAEGHKWAMLTAYD+STAR FD+AGI
Sbjct: 1   MSEQTVYGAASDQPTPK----PRVKVRTTHLQKWKAEGHKWAMLTAYDFSTARAFDDAGI 56

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP++ DEL+PLVRGVVRGA HALVVADLPFGSYE GP  AL
Sbjct: 57  PVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPHALVVADLPFGSYEEGPRQAL 116

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+KE GAHAVKLEGG+RVAEQIA L+AAGIPVMAHIGFTPQSVN LGGF+VQGRG
Sbjct: 117 ATATRFLKETGAHAVKLEGGERVAEQIATLSAAGIPVMAHIGFTPQSVNGLGGFKVQGRG 176

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCDAQVLVWQD
Sbjct: 177 DAAEQTIHDAIAVQEAGAFSVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQD 236

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAGL+SG+ A+FVK++ D+  ELRRAA QYA+EVA+ VFPAEEH F
Sbjct: 237 MAGLTSGRTAKFVKRFGDVGAELRRAASQYADEVAAGVFPAEEHSF 282


>sp|A3Q1U4|PANB_MYCSJ Tax_Id=164757 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           sp.]
          Length = 282

 Score =  414 bits (1064), Expect = e-114
 Identities = 212/286 (74%), Positives = 232/286 (81%), Gaps = 4/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ V    +D  T       R K+RT HLQK KAEGHKWAMLTAYD+STAR FD+AGI
Sbjct: 1   MSEQTVYGAASDQPTPK----PRVKVRTTHLQKWKAEGHKWAMLTAYDFSTARAFDDAGI 56

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVP++ DEL+PLVRGVVRGA HALVVADLPFGSYE GP  AL
Sbjct: 57  PVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPHALVVADLPFGSYEEGPRQAL 116

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATRF+KE GAHAVKLEGG+RVAEQIA L+AAGIPVMAHIGFTPQSVN LGGF+VQGRG
Sbjct: 117 ATATRFLKETGAHAVKLEGGERVAEQIATLSAAGIPVMAHIGFTPQSVNGLGGFKVQGRG 176

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCDAQVLVWQD
Sbjct: 177 DAAEQTIHDAIAVQEAGAFSVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQD 236

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAGL+SG+ A+FVK++ D+  ELRRAA QYA+EVA+ VFPAEEH F
Sbjct: 237 MAGLTSGRTAKFVKRFGDVGAELRRAASQYADEVAAGVFPAEEHSF 282


>tr|A4TBM9|A4TBM9_MYCGI Tax_Id=350054 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Mycobacterium gilvum]
          Length = 283

 Score =  405 bits (1041), Expect = e-111
 Identities = 209/286 (73%), Positives = 232/286 (81%), Gaps = 3/286 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ+V  YGA   T+ + S  R K+RT HL K K+EGHKWAMLTAYDYSTA VFDEA I
Sbjct: 1   MSEQSV--YGAGAETA-VSSAPRVKVRTHHLHKWKSEGHKWAMLTAYDYSTAAVFDEAQI 57

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVPV+ DEL+PLVRGVVRGA HALVVADLPFGSYE G   AL
Sbjct: 58  PVLLVGDSAANVVYGYDTTVPVTLDELIPLVRGVVRGAPHALVVADLPFGSYEAGAQQAL 117

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATR +KE GAHAVKLEGG+RVAEQIA +TAAGIPVMAHIGFTPQSVN LGGFRVQGRG
Sbjct: 118 ATATRMLKETGAHAVKLEGGERVAEQIAAVTAAGIPVMAHIGFTPQSVNGLGGFRVQGRG 177

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG NCDAQVLVWQD
Sbjct: 178 DAAEQTIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQD 237

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG+++G+ A+FVK++  +  ELRRAA +YA+EVA+ VFPAEEH +
Sbjct: 238 MAGMTNGRTAKFVKRFGAVGDELRRAATEYAQEVATGVFPAEEHSY 283


>tr|A0R087|A0R087_MYCS2 Tax_Id=246196 (panB)SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Mycobacterium smegmatis]
          Length = 287

 Score =  402 bits (1032), Expect = e-110
 Identities = 203/289 (70%), Positives = 234/289 (80%), Gaps = 5/289 (1%)

Query: 1   MSEQNVNVYGADPSTSSI---QSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDE 57
           MSEQ +  YGA  ++ S+   +  QRTK+RT  LQK KAEGHKWAMLT YDYS+ARVFD+
Sbjct: 1   MSEQPI--YGAANTSQSVVDTKPAQRTKVRTLTLQKWKAEGHKWAMLTCYDYSSARVFDD 58

Query: 58  AGIPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPT 117
           AGIPVLLVGDSAANVVYGYDTTVP+S DEL+PL R VV+GA HALV+ DLPFGSYE GP+
Sbjct: 59  AGIPVLLVGDSAANVVYGYDTTVPISIDELIPLARAVVKGAPHALVIGDLPFGSYEDGPS 118

Query: 118 AALAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQ 177
            ALA ATRFMKE G HAVKLEGG+RVA+QIA L+ AGIPV+AHIGFTPQSVN LGGFRVQ
Sbjct: 119 QALATATRFMKEAGVHAVKLEGGERVADQIATLSRAGIPVVAHIGFTPQSVNGLGGFRVQ 178

Query: 178 GRGGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLV 237
           GRG  A+QT                +EMVP ELATQITGKLTIPT+GIGAG NCDAQVLV
Sbjct: 179 GRGDAADQTIRDAIAVAEAGAVAVVLEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLV 238

Query: 238 WQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           WQDMAGL+SGK A+FV+++ D+ GEL RAA Q+A++VA+ VFPAEEH +
Sbjct: 239 WQDMAGLTSGKTAKFVRRFGDVGGELHRAATQFADDVAAGVFPAEEHSY 287


>sp|Q9L7B2|PANB_MYCVP Tax_Id=350058 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Mycobacterium
           vanbaalenii]
          Length = 280

 Score =  394 bits (1012), Expect = e-108
 Identities = 205/286 (71%), Positives = 225/286 (78%), Gaps = 6/286 (2%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSEQ V  YGA           R K+RT HL K KAEGHKWAMLTAYDYSTA VFDEA I
Sbjct: 1   MSEQPV--YGAAAEAPK----PRVKVRTHHLHKWKAEGHKWAMLTAYDYSTAAVFDEAEI 54

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
           PVLLVGDSAANVVYGYDTTVPV+ DEL+PLVRGVVRGA HALVVADLPFGSYE GP  AL
Sbjct: 55  PVLLVGDSAANVVYGYDTTVPVTLDELIPLVRGVVRGAPHALVVADLPFGSYEAGPQQAL 114

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
           A ATR +KE GAHAVKLEGG+RVA+QIA ++AAGIPVMAHIGFTPQSVN LGGFRVQGRG
Sbjct: 115 ATATRMLKETGAHAVKLEGGERVADQIAAVSAAGIPVMAHIGFTPQSVNGLGGFRVQGRG 174

Query: 181 GDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQD 240
             AEQT                MEMVP ELATQITGKLTIPT+GIGAG +CDAQVLVWQD
Sbjct: 175 DAAEQTIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPSCDAQVLVWQD 234

Query: 241 MAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           MAG+++GK A+FVK++  +  ELRRAA  YA EVA+  FPA+EH +
Sbjct: 235 MAGMTNGKTAKFVKRFGAVGDELRRAASDYAREVATGAFPADEHSY 280


>tr|B1MNU8|B1MNU8_MYCA9 Tax_Id=561007 SubName:
           Full=3-methyl-2-oxobutanoate
           hydroxymethyltransferase;[Mycobacterium abscessus]
          Length = 292

 Score =  385 bits (988), Expect = e-105
 Identities = 199/287 (69%), Positives = 226/287 (78%), Gaps = 8/287 (2%)

Query: 8   VYGA------DPSTS--SIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAG 59
           +YGA      +P T   ++++ + ++ R  HLQK KAEGHKW+MLTAYDYSTARVF++AG
Sbjct: 6   LYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWKAEGHKWSMLTAYDYSTARVFNDAG 65

Query: 60  IPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAA 119
           IPVLLVGDSAANVVYGYDTTVP++ DEL+PLVRGVVRGA  ALVVADLPFGSYE G   A
Sbjct: 66  IPVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPEALVVADLPFGSYEGGAAQA 125

Query: 120 LAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGR 179
           LA ATRFMKE GAHAVKLEGG+RVAEQIA LTAAGIPV+AHIGFTPQSVN LGG+RVQGR
Sbjct: 126 LASATRFMKEAGAHAVKLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNGLGGYRVQGR 185

Query: 180 GGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQ 239
              A Q                 MEMVP ELATQITGKLTIPT+GIGAG  CDAQVLVWQ
Sbjct: 186 DDAAAQLIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQVLVWQ 245

Query: 240 DMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           DMAG++SGK A+FVKQ+  +  ELR+AA QYA+EVA  VFPA EH +
Sbjct: 246 DMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHSY 292


>sp|Q0SHJ0|PANB_RHOSR Tax_Id=101510 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Rhodococcus sp.]
          Length = 289

 Score =  384 bits (986), Expect = e-105
 Identities = 196/279 (70%), Positives = 220/279 (78%), Gaps = 4/279 (1%)

Query: 8   VYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGD 67
           +YG+ PS      + + K RT HLQ MKAEG +WAMLTAYDYS+AR+F+EAGIPVLLVGD
Sbjct: 15  LYGSAPS----HDVPKRKTRTHHLQAMKAEGERWAMLTAYDYSSARIFEEAGIPVLLVGD 70

Query: 68  SAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFM 127
           SAANVVYGY+TTVPV+ DELLPLVRGVVRGA HALVVADLPFGSYE  P  ALA ATRFM
Sbjct: 71  SAANVVYGYETTVPVTIDELLPLVRGVVRGAPHALVVADLPFGSYESSPEQALASATRFM 130

Query: 128 KEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTX 187
           KEG AHAVKLEGG+RVA QIA +TAAGIPVMAH+GFTPQSVNSLGGFRVQGRG  AEQ  
Sbjct: 131 KEGLAHAVKLEGGERVAPQIAAITAAGIPVMAHVGFTPQSVNSLGGFRVQGRGDAAEQLV 190

Query: 188 XXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSG 247
                          MEMVP E+A Q+T KLTIPT+GIGAG+ CDAQVLVWQDMAG +SG
Sbjct: 191 ADAIAVQEAGAFSVVMEMVPAEIAGQVTRKLTIPTVGIGAGVECDAQVLVWQDMAGYTSG 250

Query: 248 KVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           K A+FVK++ ++  ELR AA  YA EV +  FPAEEH F
Sbjct: 251 KTAKFVKRFGNVGDELRSAAAAYATEVRAGTFPAEEHSF 289


>tr|C1AUD4|C1AUD4_RHOOB Tax_Id=632772 (panB)SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Rhodococcus opacus]
          Length = 289

 Score =  379 bits (972), Expect = e-103
 Identities = 193/279 (69%), Positives = 218/279 (78%), Gaps = 4/279 (1%)

Query: 8   VYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGD 67
           +YG+ PS      + + K R  HLQ MKAEG +W+MLTAYDYS+AR+F+EAGIPVLLVGD
Sbjct: 15  LYGSAPS----HDVPKRKTRIHHLQAMKAEGERWSMLTAYDYSSARIFEEAGIPVLLVGD 70

Query: 68  SAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFM 127
           SAANVVYGY+TTVPV+ DELLPLVRGVVRGA HALVVADLPFGSYE  P  ALA ATRFM
Sbjct: 71  SAANVVYGYETTVPVTIDELLPLVRGVVRGAPHALVVADLPFGSYESSPEQALASATRFM 130

Query: 128 KEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTX 187
           KEG AHAVKLEGG+RVA QIA +TAAGIPVMAH+GFTPQSVNSLGGFRVQGRG  +EQ  
Sbjct: 131 KEGLAHAVKLEGGERVAPQIAAITAAGIPVMAHVGFTPQSVNSLGGFRVQGRGDASEQLV 190

Query: 188 XXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSG 247
                          MEMVP E+A Q+T KLTIPT+GIGAG  CDAQVLVWQDMAG +SG
Sbjct: 191 ADAIAVQEAGAFSVVMEMVPAEIAGQVTRKLTIPTVGIGAGAECDAQVLVWQDMAGYTSG 250

Query: 248 KVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           K A+FVK++ ++  ELR AA  YA EV +  FPAEEH F
Sbjct: 251 KTAKFVKRFGNVGDELRTAAAAYAAEVRTGTFPAEEHSF 289


>sp|Q5YZ95|PANB_NOCFA Tax_Id=37329 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Nocardia
           farcinica]
          Length = 283

 Score =  377 bits (967), Expect = e-102
 Identities = 194/275 (70%), Positives = 216/275 (78%), Gaps = 1/275 (0%)

Query: 13  PSTSSIQSIQ-RTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAAN 71
           P+  + Q  Q R K R  HL++MKA+G +WAMLTAYDYS+AR+F+EAGIPVLLVGDSAAN
Sbjct: 9   PAYGAAQPAQPRRKTRIPHLRQMKADGERWAMLTAYDYSSARLFEEAGIPVLLVGDSAAN 68

Query: 72  VVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGG 131
           VVYGYDTTVP++ DEL+PLVRGVVRGA HALVVADLPFG+YE     ALA ATRFMKEGG
Sbjct: 69  VVYGYDTTVPITVDELIPLVRGVVRGAPHALVVADLPFGTYEGSAQQALAAATRFMKEGG 128

Query: 132 AHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXX 191
           AHAVKLEGG+RVAEQIA LTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG  AEQ      
Sbjct: 129 AHAVKLEGGERVAEQIALLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDGAEQLIADAI 188

Query: 192 XXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVAR 251
                      MEMVP ELA Q+T KLTIPTIGIGAG +CDAQVLVWQDMAG +SGK A+
Sbjct: 189 AVQEAGAFSVVMEMVPAELAGQVTRKLTIPTIGIGAGPDCDAQVLVWQDMAGYTSGKTAK 248

Query: 252 FVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           FVK++ DI  +LR AA  YA EV    FP  EH F
Sbjct: 249 FVKRFGDIGDQLRAAAAAYAAEVREGTFPGPEHSF 283


>tr|C1A174|C1A174_RHOE4 Tax_Id=234621 (panB)SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Rhodococcus erythropolis]
          Length = 283

 Score =  369 bits (946), Expect = e-100
 Identities = 186/279 (66%), Positives = 218/279 (78%), Gaps = 1/279 (0%)

Query: 8   VYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGD 67
           +YG+ P+ SS  + +R K R  HL +MK  G +W+MLTAYDYSTAR+F++AGIPVLLVGD
Sbjct: 6   LYGSVPTASSTDAPKR-KTRIHHLAEMKQNGERWSMLTAYDYSTARIFEDAGIPVLLVGD 64

Query: 68  SAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFM 127
           SAANVVYGYDTTVP++ DELLPLVRGVVRGA HALVVADLPFG+YE     ALA ATRFM
Sbjct: 65  SAANVVYGYDTTVPITVDELLPLVRGVVRGAPHALVVADLPFGTYEGSAEQALATATRFM 124

Query: 128 KEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTX 187
           KEG AHAVKLEGG+R+++QIA +T+AGIPVMAH+GFTPQSVNSLGGFRVQGRG  AEQ  
Sbjct: 125 KEGLAHAVKLEGGERMSKQIAAITSAGIPVMAHVGFTPQSVNSLGGFRVQGRGDAAEQLV 184

Query: 188 XXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSG 247
                          MEMVP E+A Q++ KLTIPT+GIGAG  CDAQVLVWQDMAG +SG
Sbjct: 185 ADAIAVQEAGAFSVVMEMVPAEIAGQVSRKLTIPTVGIGAGSECDAQVLVWQDMAGYTSG 244

Query: 248 KVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           K A+FVK++ ++  ELR AA  YA EV +  FPA EH F
Sbjct: 245 KTAKFVKRFGNVGDELRSAAAAYASEVRTGAFPAAEHSF 283


>tr|C3JIP0|C3JIP0_RHOER Tax_Id=596309 (panB)SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Rhodococcus erythropolis SK121]
          Length = 283

 Score =  369 bits (946), Expect = e-100
 Identities = 186/279 (66%), Positives = 218/279 (78%), Gaps = 1/279 (0%)

Query: 8   VYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGD 67
           +YG+ P+ SS  + +R K R  HL +MK  G +W+MLTAYDYSTAR+F++AGIPVLLVGD
Sbjct: 6   LYGSVPTASSTDAPKR-KTRIHHLAEMKQNGERWSMLTAYDYSTARIFEDAGIPVLLVGD 64

Query: 68  SAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFM 127
           SAANVVYGYDTTVP++ DELLPLVRGVVRGA HALVVADLPFG+YE     ALA ATRFM
Sbjct: 65  SAANVVYGYDTTVPITVDELLPLVRGVVRGAPHALVVADLPFGTYEGSAEQALATATRFM 124

Query: 128 KEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTX 187
           KEG AHAVKLEGG+R+++QIA +T+AGIPVMAH+GFTPQSVNSLGGFRVQGRG  AEQ  
Sbjct: 125 KEGLAHAVKLEGGERMSKQIAAITSAGIPVMAHVGFTPQSVNSLGGFRVQGRGDAAEQLV 184

Query: 188 XXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSG 247
                          MEMVP E+A Q++ KLTIPT+GIGAG  CDAQVLVWQDMAG +SG
Sbjct: 185 ADAIAVQEAGAFSVVMEMVPAEIAGQVSRKLTIPTVGIGAGSECDAQVLVWQDMAGYTSG 244

Query: 248 KVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           K A+FVK++ ++  ELR AA  YA EV +  FPA EH F
Sbjct: 245 KTAKFVKRFGNVGDELRSAAAAYASEVRTGAFPAAEHSF 283


>tr|D0LB03|D0LB03_9ACTO Tax_Id=526226 SubName:
           Full=3-methyl-2-oxobutanoatehydroxymethyltransferase;
           EC=2.1.2.11;[Gordonia bronchialis DSM 43247]
          Length = 287

 Score =  357 bits (917), Expect = 7e-97
 Identities = 189/289 (65%), Positives = 218/289 (75%), Gaps = 5/289 (1%)

Query: 1   MSEQNVNVYGAD-PSTSSIQSIQRTKIRTK--HLQKMKAEGHKWAMLTAYDYSTARVFDE 57
           MSE   +VYGA  P+ S+  S  R + +T+  HL +MK+EG KW+MLTAYDYS+A +FDE
Sbjct: 1   MSE--TSVYGAARPADSATDSPARPRRKTRVHHLAQMKSEGEKWSMLTAYDYSSAAIFDE 58

Query: 58  AGIPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPT 117
           A IPVLLVGDSAANVV GYDTT+PVS DE++PL+R VVRGA HALVVADLPFG+YE GP 
Sbjct: 59  AQIPVLLVGDSAANVVLGYDTTIPVSLDEMIPLIRAVVRGAPHALVVADLPFGTYEAGPQ 118

Query: 118 AALAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQ 177
            AL  A R  KE GAHAVKLEGG+RVA QIA L+AAGIPVMAHIGFTPQSVN LGGFR+Q
Sbjct: 119 QALESAVRIFKETGAHAVKLEGGERVAAQIAALSAAGIPVMAHIGFTPQSVNGLGGFRIQ 178

Query: 178 GRGGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLV 237
           GRG   +Q                 MEMVP +LA QIT KLTIPTIGIGAG   DAQVLV
Sbjct: 179 GRGDAGDQLIADAIAVQEAGAFSVVMEMVPADLAGQITRKLTIPTIGIGAGNETDAQVLV 238

Query: 238 WQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           WQDMAG++ GK A+FVK++AD+  ELR AA QYA+EV   VFPA EH +
Sbjct: 239 WQDMAGMTHGKTAKFVKRFADVGTELRNAAAQYADEVRRGVFPAPEHSY 287


>sp|A4FA49|PANB_SACEN Tax_Id=405948 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Saccharopolyspora
           erythraea]
          Length = 293

 Score =  332 bits (851), Expect = 3e-89
 Identities = 164/265 (61%), Positives = 197/265 (74%)

Query: 22  QRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVP 81
           +R ++RT+HL ++K  G  W MLT+YD  TAR+FDEAGIPVLLVGDSAAN VYGYDTTVP
Sbjct: 28  RRRRVRTRHLLELKQRGEAWPMLTSYDMYTARIFDEAGIPVLLVGDSAANNVYGYDTTVP 87

Query: 82  VSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQ 141
           V+ +EL+PLVR V RGA  ALVVADLPFGSYE  P  ALA A RFMKEGGAHAVKLEGG+
Sbjct: 88  VTVEELIPLVRAVTRGARSALVVADLPFGSYEASPEQALATAVRFMKEGGAHAVKLEGGR 147

Query: 142 RVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXX 201
             A  +  L  AGIPVM HIGFTPQS ++LGG+RVQGRG  AE+                
Sbjct: 148 PFARHVEALVNAGIPVMGHIGFTPQSEHTLGGYRVQGRGEQAEELAADARALQDAGAFAV 207

Query: 202 XMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAG 261
            +EMV ++ A ++T +LTIPT+GIGAG  CDAQVLVW DMAG+++G+ ARFVK+YAD+ G
Sbjct: 208 VLEMVSSDSAKRVTAELTIPTVGIGAGPECDAQVLVWTDMAGMNTGRTARFVKRYADLGG 267

Query: 262 ELRRAAMQYAEEVASAVFPAEEHCF 286
            L RAA ++A+EV    FPA EH F
Sbjct: 268 TLARAAQEFADEVRGGAFPAPEHSF 292


>tr|C4RMM0|C4RMM0_9ACTO Tax_Id=219305 SubName:
           Full=3-methyl-2-oxobutanoate
           hydroxymethyltransferase;[Micromonospora sp. ATCC 39149]
          Length = 281

 Score =  326 bits (835), Expect = 2e-87
 Identities = 163/262 (62%), Positives = 195/262 (74%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           ++RT+ L   K  G KW+MLT+YD  TA +FD AGIPVLLVGDSAAN V+GY+TT+PV+ 
Sbjct: 20  RVRTRDLLAAKERGEKWSMLTSYDQYTASIFDAAGIPVLLVGDSAANNVFGYETTLPVTT 79

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           +ELLPLVR VVR    ALVV DLPFGSYE GPT AL  A RFMKEGG HAVKLEGG+R A
Sbjct: 80  EELLPLVRAVVRATRQALVVGDLPFGSYEEGPTQALRTAVRFMKEGGCHAVKLEGGRRCA 139

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
           +QIA +  AGIPVMAHIGFTPQS ++LGG+RVQGRG  A++                 +E
Sbjct: 140 DQIATIVGAGIPVMAHIGFTPQSEHTLGGYRVQGRGDTADEVFADALAVAEAGAFAVVLE 199

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
           MVP E+A +ITG+L+IPT+GIGAG + DAQVLVWQDMAGL +GK  RFVK+YAD+AG L 
Sbjct: 200 MVPGEVAKRITGELSIPTVGIGAGPDTDAQVLVWQDMAGLRTGKAPRFVKRYADLAGALA 259

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
            A  ++A+EV    FPA EH F
Sbjct: 260 EATQRFADEVRGGEFPAAEHTF 281


>tr|C7MWE6|C7MWE6_SACVD Tax_Id=471857 SubName: Full=Ketopantoate
           hydroxymethyltransferase; EC=2.1.2.11;[Saccharomonospora
           viridis]
          Length = 299

 Score =  323 bits (828), Expect = 1e-86
 Identities = 162/279 (58%), Positives = 200/279 (71%), Gaps = 1/279 (0%)

Query: 9   YGADPSTSSIQSIQ-RTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGD 67
           YGA P T +  +   R ++R  HL+++K  G  W MLTAYD  TAR+FDEAGIPVLLVGD
Sbjct: 20  YGAAPGTPTESATPPRKRVRIHHLRELKERGEPWPMLTAYDTYTARLFDEAGIPVLLVGD 79

Query: 68  SAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFM 127
           SAAN VYGY++++P++ +E+LPLVR V R    ALVVADLPFGSY+  P  A+A A RFM
Sbjct: 80  SAANTVYGYESSLPITVEEMLPLVRAVTRSVSKALVVADLPFGSYQVSPEQAVATAARFM 139

Query: 128 KEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTX 187
           KEG AHAVKLEGG++ A  +  +TAAG+PVM HIGFTPQS ++LGG+RVQGRG   +   
Sbjct: 140 KEGRAHAVKLEGGRKFAPHVEAVTAAGVPVMGHIGFTPQSEHNLGGYRVQGRGDTGDALI 199

Query: 188 XXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSG 247
                          MEMVP E+A QIT +L IPT+GIGAG +CDAQVLVWQDMAGL +G
Sbjct: 200 ADALALQDAGAFAVVMEMVPAEIAKQITHELHIPTVGIGAGPDCDAQVLVWQDMAGLRTG 259

Query: 248 KVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           +V RFVKQYAD+AG L  A   +A++V +  FPA EH F
Sbjct: 260 RVPRFVKQYADLAGVLTTAVKAFADDVRNRTFPAPEHTF 298


>tr|C0U999|C0U999_9ACTO Tax_Id=526225 SubName: Full=Ketopantoate
           hydroxymethyltransferase; EC=2.1.2.11;[Geodermatophilus
           obscurus DSM 43160]
          Length = 276

 Score =  320 bits (819), Expect = 2e-85
 Identities = 160/262 (61%), Positives = 192/262 (73%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           ++R  HLQ+ K  G KWAMLTAYD  +A VF+EAGIPV+LVGDSA NVV G+ +TVPV+ 
Sbjct: 14  RVRVHHLQQAKERGEKWAMLTAYDTFSATVFEEAGIPVMLVGDSAGNVVLGHTSTVPVTV 73

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           +++L + + V R    AL+VADLPFGSYE  P  A A A R +KEGGA AVKLEGG RVA
Sbjct: 74  EDILGMTKAVTRSTKRALIVADLPFGSYEASPQQAFATAVRMLKEGGAQAVKLEGGVRVA 133

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
            Q   LT  GIPVMAH+GFTPQS ++LGGFRVQGRG  AEQ                 +E
Sbjct: 134 PQTRMLTENGIPVMAHVGFTPQSEHALGGFRVQGRGAGAEQLLTDAHAVQEAGAFAVVLE 193

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
           MVP E+A Q+T +L+IPTIGIGAG++CDAQVLVW DMAGL+SG+V RFVK+YAD+ GEL 
Sbjct: 194 MVPAEIAAQVTKELSIPTIGIGAGVDCDAQVLVWPDMAGLTSGRVPRFVKKYADLRGELL 253

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
           RAA +YA+EV S VFP  EH F
Sbjct: 254 RAAREYADEVRSGVFPGPEHSF 275


>sp|Q0RFD5|PANB_FRAAA Tax_Id=326424 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Frankia alni]
          Length = 303

 Score =  315 bits (808), Expect = 3e-84
 Identities = 161/279 (57%), Positives = 198/279 (70%), Gaps = 3/279 (1%)

Query: 8   VYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGD 67
           +YGA   T   +S +R++   + +   K+ G +W+MLTAYD++TA VFDEA IPVLLVGD
Sbjct: 28  LYGAPAET---RSPRRSRFTVRDVAAAKSRGERWSMLTAYDFTTATVFDEAEIPVLLVGD 84

Query: 68  SAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFM 127
           SAANVVYGYDTTVPV+ DEL+PLVR VVRGA HA+VVADLPFGSY+ GP  ALA ATRF+
Sbjct: 85  SAANVVYGYDTTVPVTVDELIPLVRAVVRGAPHAMVVADLPFGSYQAGPEQALATATRFL 144

Query: 128 KEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTX 187
           KEGGA AVKLEGG RVA  +A L  AGIPV+ H+G TPQS+++LGG+RVQGR    E   
Sbjct: 145 KEGGAQAVKLEGGARVAPAVAALVGAGIPVIGHLGLTPQSIHALGGYRVQGRDEAGEVLL 204

Query: 188 XXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSG 247
                          +E+VP +LA ++T +L I T+GIGAG +CDAQVLVWQDMAGLS G
Sbjct: 205 ADALAIEAAGAFAVVLEVVPADLAARVTKELHIATVGIGAGADCDAQVLVWQDMAGLSGG 264

Query: 248 KVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
            V RFVK+YAD+   L  A   Y +EV    +P  EH +
Sbjct: 265 HVPRFVKRYADLRTVLGDAVRTYRDEVRGGQYPTVEHSY 303


>tr|A8LE65|A8LE65_FRASN Tax_Id=298653 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Frankia sp.]
          Length = 313

 Score =  313 bits (802), Expect = 1e-83
 Identities = 158/276 (57%), Positives = 195/276 (70%), Gaps = 2/276 (0%)

Query: 11  ADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAA 70
           A P+T    S  RT +R   ++  K  G +WAMLTAYD  TA +FDEAGIPVLLVGDSAA
Sbjct: 40  ATPTTIRPASHSRTTVRD--IRAAKDRGQRWAMLTAYDVITAGIFDEAGIPVLLVGDSAA 97

Query: 71  NVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEG 130
           N VYGY+TTVP++ DEL+PLVR VVRGA HA+VVADLPFGSY+  P  AL  ATRF+KEG
Sbjct: 98  NTVYGYETTVPITVDELVPLVRAVVRGAPHAMVVADLPFGSYQASPEQALTTATRFLKEG 157

Query: 131 GAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXX 190
           GAHAVKLEGG RV  Q+  L AAGIPVM H+G TPQSV++ GG+RVQGR G  E      
Sbjct: 158 GAHAVKLEGGARVLPQVGALVAAGIPVMGHLGLTPQSVHAFGGYRVQGRDGAGEVLLADA 217

Query: 191 XXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVA 250
                       +E+VP +LA ++T +L I T+GIGAG +CDAQVLVWQDMAGL+ G+  
Sbjct: 218 LGLQEAGAFAVVLEVVPADLAARVTKELLISTVGIGAGADCDAQVLVWQDMAGLTGGQAP 277

Query: 251 RFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           RFVK++AD+   L  AA  + +EV+  ++P  EH +
Sbjct: 278 RFVKRFADLRTALTDAAAAFRDEVSGGLYPTVEHSY 313


>tr|A3TLZ3|A3TLZ3_9MICO Tax_Id=313589 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Janibacter sp. HTCC2649]
          Length = 289

 Score =  312 bits (799), Expect = 3e-83
 Identities = 163/283 (57%), Positives = 191/283 (67%), Gaps = 5/283 (1%)

Query: 4   QNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVL 63
           + +N YG     +  Q+  + +IR  HLQKMK  G KWAMLTAYD   A +FDEAGIP L
Sbjct: 10  ETINPYG-----TGAQAAPQKRIRVPHLQKMKETGEKWAMLTAYDMYAAEIFDEAGIPCL 64

Query: 64  LVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVA 123
           LVGDSA N VYG++TTVPV+ D L+PL R V   A HA+VVADLPFGSY+  P  ALA A
Sbjct: 65  LVGDSAGNNVYGFETTVPVTVDHLVPLCRAVTSAAKHAMVVADLPFGSYQASPQQALATA 124

Query: 124 TRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDA 183
           TRFMKEG AHAVKLEGG+ +  +I  L  AGIPVM HIGFTPQS + LGG+RVQGRG  A
Sbjct: 125 TRFMKEGLAHAVKLEGGKAMVPEIELLVRAGIPVMGHIGFTPQSEHVLGGYRVQGRGDGA 184

Query: 184 EQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAG 243
           ++                 +EMVP   A ++T  L IP IGIGAG +CDAQVLVWQDMAG
Sbjct: 185 DRLLEDALALEAAGCFAIVIEMVPAPAAKKVTEALRIPIIGIGAGPDCDAQVLVWQDMAG 244

Query: 244 LSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           L  G+  RFVK+Y D+   L  AA +YA EVAS  FPA EH F
Sbjct: 245 LRGGRAPRFVKKYMDMRTGLADAAKEYAAEVASGAFPAAEHSF 287


>tr|A4XA35|A4XA35_SALTO Tax_Id=369723 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Salinispora tropica]
          Length = 281

 Score =  310 bits (794), Expect = 1e-82
 Identities = 157/262 (59%), Positives = 188/262 (71%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           ++R + L   K  G +WAMLT+YD  TA +FD AGIPVLLVGDSAAN V+GY+TT+PV+ 
Sbjct: 20  RVRARDLLAAKERGERWAMLTSYDQYTAGIFDAAGIPVLLVGDSAANNVFGYETTLPVTP 79

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           DELLPLVR VV      LVV DLPFGSYE GP AAL  A RFMKEGG HAVKLEGG+  A
Sbjct: 80  DELLPLVRAVVGATRQTLVVGDLPFGSYEEGPAAALRTAVRFMKEGGCHAVKLEGGRHCA 139

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
           EQIA +  AGIPVMAHIGFTPQ  ++LGG+RVQGRG  AE+                 +E
Sbjct: 140 EQIAAIVRAGIPVMAHIGFTPQREHTLGGYRVQGRGDTAEEVLADARAIAEAGAFAVVLE 199

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
           MVP ++A +IT +LTIPT+GIGAG + DAQVLVWQDMAGL +G+  RFVK+YA++A  L 
Sbjct: 200 MVPGDVAKRITAELTIPTVGIGAGPDTDAQVLVWQDMAGLRTGRTPRFVKRYANLADTLG 259

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
            A  ++A+EV    FPA EH F
Sbjct: 260 EATRRFADEVRDGGFPATEHTF 281


>tr|A8LZ26|A8LZ26_SALAI Tax_Id=391037 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Salinispora arenicola]
          Length = 281

 Score =  310 bits (793), Expect = 2e-82
 Identities = 155/262 (59%), Positives = 188/262 (71%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           ++R + L   K  G +W MLT+YD  TA +FD AGIPVLLVGDSAAN V+GY+TT+PV+A
Sbjct: 20  RVRARDLLAAKERGERWPMLTSYDQYTAAIFDAAGIPVLLVGDSAANNVFGYETTLPVTA 79

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           +ELLPLVR VVR     LVV DLPFGSYE GP AAL  A RFMKEGG HAVKLEGG+  A
Sbjct: 80  EELLPLVRAVVRATRQTLVVGDLPFGSYEEGPAAALRTAVRFMKEGGCHAVKLEGGRHCA 139

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
           EQIA +  AGIPVMAH+GFTPQ  ++LGG+RVQGRG  AE+                 +E
Sbjct: 140 EQIAAIVRAGIPVMAHVGFTPQREHTLGGYRVQGRGDTAEEVVADARAVADAGAFAVVLE 199

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
           MVP ++A +IT +LTIPT+GIGAG + DAQVLVWQDMAGL +G+  RFVK+YA++A  L 
Sbjct: 200 MVPGDVAKRITAELTIPTVGIGAGPDTDAQVLVWQDMAGLRTGRTPRFVKRYANLADTLG 259

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
            A  ++A+EV    FP  EH F
Sbjct: 260 EATRRFADEVREGGFPTAEHTF 281


>sp|Q2J886|PANB_FRASC Tax_Id=106370 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Frankia sp.]
          Length = 296

 Score =  308 bits (788), Expect = 6e-82
 Identities = 155/264 (58%), Positives = 187/264 (70%)

Query: 23  RTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPV 82
           R++   + +   K  G KW+MLTAYD +TA VFDEA IPVLLVGDSAANVVYGYDTTVP+
Sbjct: 33  RSRFTVRDVAAAKNRGEKWSMLTAYDATTAAVFDEAEIPVLLVGDSAANVVYGYDTTVPI 92

Query: 83  SADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQR 142
           + DELLPLVR VVRGA HA+VVADLPFGSY+ GP  ALA ATRF+KEGGAHAVKLEGG R
Sbjct: 93  TVDELLPLVRAVVRGAPHAMVVADLPFGSYQGGPAEALASATRFLKEGGAHAVKLEGGSR 152

Query: 143 VAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXX 202
           V   +  L  AGIPV+ H+G TPQS++++GG+RVQGR    E                  
Sbjct: 153 VVRAVDALVGAGIPVIGHLGLTPQSIHTIGGYRVQGRDEAGEILLADALALEAAGAFAVV 212

Query: 203 MEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGE 262
           +E+VP +LAT++T +L I T+GIGAG  CDAQVLVWQDMAGLS G+  RFVK+YAD+   
Sbjct: 213 LEVVPADLATRVTKELRIATVGIGAGSGCDAQVLVWQDMAGLSGGRTPRFVKRYADLRTI 272

Query: 263 LRRAAMQYAEEVASAVFPAEEHCF 286
           L  AA  Y  +V    +P  EH +
Sbjct: 273 LADAARAYRADVRDGRYPTIEHSY 296


>tr|C1YSU2|C1YSU2_NOCDA Tax_Id=446468 SubName: Full=Ketopantoate
           hydroxymethyltransferase; EC=2.1.2.11;[Nocardiopsis
           dassonvillei subsp. dassonvillei DSM 43111]
          Length = 289

 Score =  306 bits (784), Expect = 2e-81
 Identities = 161/277 (58%), Positives = 188/277 (67%), Gaps = 1/277 (0%)

Query: 10  GADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSA 69
           GA    +    +   ++  + L   K  G +W MLTAYD  TARVFDEAGIPVLLVGDSA
Sbjct: 12  GAPTGNTLYGGVTSRRVTIRDLAAAKGRGERWPMLTAYDALTARVFDEAGIPVLLVGDSA 71

Query: 70  ANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKE 129
           ANVVYGYDTTVPV+ DELLPL   V R    ALVVADLPFGSY+  P  AL  A+RFMKE
Sbjct: 72  ANVVYGYDTTVPVTVDELLPLTAAVSRSTRRALVVADLPFGSYQASPQQALEAASRFMKE 131

Query: 130 GGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXX 189
           GGA AVKLEGG  V  Q+  L +AG+PVMAH+G TPQSVN+LGG+RVQGRG  A      
Sbjct: 132 GGAQAVKLEGGHAVVPQVELLVSAGVPVMAHLGLTPQSVNTLGGYRVQGRGEAAAGLLKD 191

Query: 190 XXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKV 249
                        +E VP ELA Q+T +L+IPT+GIGAG + DAQVLVWQDMAGLS  KV
Sbjct: 192 AKEMERAGAFAVVLECVPAELAAQVTEQLSIPTVGIGAGPSTDAQVLVWQDMAGLSP-KV 250

Query: 250 ARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           A+FVK YA++   LR AA  YA+EV +  FP E H +
Sbjct: 251 AKFVKTYANLHETLREAASAYADEVVNGAFPEERHSY 287


>tr|C1WX85|C1WX85_9ACTO Tax_Id=479435 SubName:
           Full=3-methyl-2-oxobutanoate
           hydroxymethyltransferase;[Kribbella flavida DSM 17836]
          Length = 795

 Score =  302 bits (774), Expect = 3e-80
 Identities = 155/262 (59%), Positives = 184/262 (70%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           K R  HL+ +K  G KWAMLTAYD  TA +FDEAGIPVLLVGDSAAN VYGY++T+ V+ 
Sbjct: 534 KYRIHHLRDLKNRGEKWAMLTAYDQYTAEIFDEAGIPVLLVGDSAANNVYGYESTLRVTV 593

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           DEL+PL R V   A  ALVVADLPFGSY+  P  A   A RFMKE G  AVKLEGG+ V 
Sbjct: 594 DELIPLARAVATAAQRALVVADLPFGSYQASPEQAFHTAVRFMKEAGVQAVKLEGGRTVV 653

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
             +  LT +GIPVMAHIGFTPQS +S+GG+RVQGRG  A                   +E
Sbjct: 654 PAVEKLTRSGIPVMAHIGFTPQSEHSIGGYRVQGRGDQAAGLIDDAVALAEAGAFSVVLE 713

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
           MVP ++A +I+ ++ +PTIGIGAG + DAQVLVWQDMAGL SG + RFVKQYAD+ G L 
Sbjct: 714 MVPGDVAAEISKRIPVPTIGIGAGRDTDAQVLVWQDMAGLRSGPMPRFVKQYADLRGILT 773

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
           +AA  YA EVA+  FPA+EH F
Sbjct: 774 QAATTYAAEVATGTFPADEHTF 795


>tr|C4EA96|C4EA96_STRRS Tax_Id=479432 SubName: Full=Ketopantoate
           hydroxymethyltransferase; EC=2.1.2.11;[Streptosporangium
           roseum DSM 43021]
          Length = 281

 Score =  301 bits (771), Expect = 6e-80
 Identities = 152/262 (58%), Positives = 185/262 (70%), Gaps = 1/262 (0%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           +I  + +   K  G KW M+TAYD  TARVFDEAGIPVLLVGDSAA VVYGYD+T+PVS 
Sbjct: 20  RITVRDIAAAKERGEKWPMVTAYDAMTARVFDEAGIPVLLVGDSAAMVVYGYDSTLPVSV 79

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           D+L+PL   VVRG+  A+VVADLPFGSY+  P  AL  A RFMKE GAHAVKLEGG+RV 
Sbjct: 80  DDLMPLTAAVVRGSSRAMVVADLPFGSYQSSPQQALETAARFMKEAGAHAVKLEGGRRVL 139

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
            Q+  L +AGIPVMAH+G TPQSVN+ GG+RVQGRG   ++                 +E
Sbjct: 140 PQVEALVSAGIPVMAHLGLTPQSVNAFGGYRVQGRGQSGDELMADAKDLEYAGAFSVVLE 199

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
            VP ELA ++T  L+IPTIGIGAG   DAQVLVWQD+ GL+    A+FVK+Y D+AGE+ 
Sbjct: 200 CVPAELAERVTASLSIPTIGIGAGPATDAQVLVWQDLMGLTP-HPAKFVKKYFDLAGEMD 258

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
           RA   +A+EV +  FPA EH +
Sbjct: 259 RAVRDFADEVTTGAFPAPEHSY 280


>tr|A6WD73|A6WD73_KINRD Tax_Id=266940 SubName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11;[Kineococcus radiotolerans]
          Length = 276

 Score =  298 bits (762), Expect = 6e-79
 Identities = 156/264 (59%), Positives = 179/264 (67%), Gaps = 1/264 (0%)

Query: 23  RTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPV 82
           R + R  H Q+ K  G KWAMLT+YD  TA VFDEAGIP LLVGDSAAN V+G  TT+PV
Sbjct: 14  RRRTRVHHFQQWKDAGEKWAMLTSYDAMTAAVFDEAGIPALLVGDSAANTVFGMPTTLPV 73

Query: 83  SADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQR 142
           + D LLPLVR VV GA HA VVADLPFGSYE     A+A A R MKEGGAHAVK EGG R
Sbjct: 74  TLDHLLPLVRAVVAGAPHAFVVADLPFGSYEVSDDLAVASAVRVMKEGGAHAVKFEGGAR 133

Query: 143 VAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXX 202
            A ++  +  AGIPVMAHIGFTPQS ++LGG+RVQGRG   EQ                 
Sbjct: 134 RAGRVRAVVEAGIPVMAHIGFTPQSEHALGGYRVQGRGEAGEQVLADARALAEAGAFAVL 193

Query: 203 MEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGE 262
           MEMVP ++A Q+T  L +PT+GIGAG   D QVLVWQD AGLS  + A+FVK++AD+   
Sbjct: 194 MEMVPADVAAQVTRTLAVPTVGIGAGSGTDGQVLVWQDFAGLSE-RTAKFVKRFADVRTA 252

Query: 263 LRRAAMQYAEEVASAVFPAEEHCF 286
           L  AA QYAEEV    FP  EH F
Sbjct: 253 LSDAARQYAEEVRGGSFPGPEHSF 276


>sp|Q6AFH4|PANB_LEIXX Tax_Id=59736 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Leifsonia xyli
           subsp. xyli]
          Length = 277

 Score =  295 bits (756), Expect = 3e-78
 Identities = 150/262 (57%), Positives = 180/262 (68%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           ++RT+H Q  K EG ++  LT+YD  TA++FDEAGI  LLVGDSAAN V GYDTT+P++ 
Sbjct: 16  RVRTRHFQAAKEEGSRFTGLTSYDTLTAQIFDEAGIDFLLVGDSAANTVLGYDTTLPMTV 75

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           DEL+PL R V R A  A VVADLPFGSYE GP  AL  A RFMKE GAHAVKLEGG+R A
Sbjct: 76  DELIPLTRAVARAAKRAFVVADLPFGSYETGPQEALRTAVRFMKETGAHAVKLEGGERSA 135

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
           EQI  +  AG+PVM HIGFTPQS + LGG  VQGRG  AEQ                 +E
Sbjct: 136 EQIRRIVDAGVPVMGHIGFTPQSEHGLGGHLVQGRGQGAEQVVDDAHAVEEAGAFAVVLE 195

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
           MVP ++A ++T +L IPTIG+GAG + D Q+LVW D AG ++G+V RF KQYAD+   L 
Sbjct: 196 MVPADVAQRVTQELRIPTIGVGAGPHVDGQLLVWTDWAGFTTGRVPRFAKQYADLKDVLT 255

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
            AA  Y +EV S VFP  EH F
Sbjct: 256 EAARMYRDEVGSGVFPGPEHSF 277


>tr|C4DC95|C4DC95_9ACTO Tax_Id=446470 SubName: Full=Ketopantoate
           hydroxymethyltransferase; EC=2.1.2.11;[Stackebrandtia
           nassauensis DSM 44728]
          Length = 280

 Score =  295 bits (754), Expect = 5e-78
 Identities = 154/263 (58%), Positives = 185/263 (70%), Gaps = 1/263 (0%)

Query: 24  TKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVS 83
           +++RT+ L+  K  G KWAMLT+YD  TA +FDE GIP LL+GDSAAN V+GY+TT+PV+
Sbjct: 18  SRVRTRDLKLAKERGEKWAMLTSYDQYTAAMFDEIGIPALLIGDSAANNVFGYETTLPVT 77

Query: 84  ADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRV 143
            DELLPLV  VVR     LVVADLPFGSYE  P  AL  A RFMK  GA+AVKLEGG R+
Sbjct: 78  IDELLPLVSAVVRSTKRTLVVADLPFGSYEASPQQALESAVRFMK-AGANAVKLEGGVRM 136

Query: 144 AEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXM 203
            EQIA LT AGIPVMAHIGFTPQS N +GG+RV GRG  A+                  +
Sbjct: 137 REQIAALTGAGIPVMAHIGFTPQSENLVGGYRVAGRGEHADSVLADAYAVAEAGAFAVVL 196

Query: 204 EMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGEL 263
           EMV +++A ++T +L IPTIGIGAG + DAQVLVWQDMAGL  G   RFVK+YA++A  +
Sbjct: 197 EMVMSDVAARVTKELEIPTIGIGAGGDTDAQVLVWQDMAGLRQGPAPRFVKRYANVASVI 256

Query: 264 RRAAMQYAEEVASAVFPAEEHCF 286
             AA  YA+EV +  FPA EH F
Sbjct: 257 AEAAKTYADEVKNGAFPAPEHGF 279


>sp|A1SIB6|PANB_NOCSJ Tax_Id=196162 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Nocardioides sp.]
          Length = 295

 Score =  292 bits (748), Expect = 3e-77
 Identities = 154/289 (53%), Positives = 191/289 (66%), Gaps = 3/289 (1%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRT---KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDE 57
           MS +    YG  P+ +           +IRT HL++MK  G K+AMLTAY+   A+ FDE
Sbjct: 7   MSPEETAPYGTGPARAESAPDAPAPIKRIRTHHLREMKQRGEKFAMLTAYEQYAAQTFDE 66

Query: 58  AGIPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPT 117
           AGI VLLVGDSA+N V+  +T++PV+ DEL+PL R V R    ALVVADLPFGSY+  P 
Sbjct: 67  AGIEVLLVGDSASNNVFANETSLPVTVDELIPLARAVSRSVRRALVVADLPFGSYQASPE 126

Query: 118 AALAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQ 177
            A   A RFMKE  AHAVKLEGG  +A Q+  LT  GIPVMAHIGFTPQS ++LGG+RVQ
Sbjct: 127 QAYLTAVRFMKEANAHAVKLEGGIEMAPQVRKLTEGGIPVMAHIGFTPQSEHNLGGYRVQ 186

Query: 178 GRGGDAEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLV 237
           GRG  A +                 MEMVP ++A ++T  ++IPTIGIGAGL+CD QVLV
Sbjct: 187 GRGEAAARVVAEAVAMEQAGAFAVVMEMVPGDVAAEVTKSVSIPTIGIGAGLDCDGQVLV 246

Query: 238 WQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           WQD  GL +G++ RFVKQYAD+ G L +AA  YA +V +  FP  EH F
Sbjct: 247 WQDAFGLRTGRMPRFVKQYADLHGVLLQAARDYAADVKAGTFPGPEHTF 295


>tr|C6WMD0|C6WMD0_ACTMD Tax_Id=446462 SubName:
           Full=3-methyl-2-oxobutanoatehydroxymethyltransferase;
           EC=2.1.2.11;[Actinosynnema mirum]
          Length = 287

 Score =  291 bits (744), Expect = 8e-77
 Identities = 151/262 (57%), Positives = 181/262 (69%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           ++R  HLQ++K  G  W MLT+YD  TA +FDEAGIPVLLVGDSA+N VYGY++++PV+ 
Sbjct: 25  RVRIHHLQELKDRGEPWPMLTSYDMYTAELFDEAGIPVLLVGDSASNNVYGYESSIPVTV 84

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           DELLPLVRGV R    +LVVADLPFGSY+     A+A A RFMKEG AHAVKLEGG+  A
Sbjct: 85  DELLPLVRGVTRAVKRSLVVADLPFGSYQVSVEQAVATAVRFMKEGRAHAVKLEGGRAFA 144

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXXME 204
             I  +  AGIPVMAHIGFTPQ  + LGGFRVQGR    +                  +E
Sbjct: 145 PHIRAIVDAGIPVMAHIGFTPQHEHQLGGFRVQGRNEAFDAVVADAHAVQEAGAFSVVLE 204

Query: 205 MVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELR 264
           MV +E+A +IT +L IPT+GIGAG + DAQVLVWQDM GL  GK  RFVK+YAD+AG + 
Sbjct: 205 MVTSEVAKKITHELRIPTVGIGAGPDTDAQVLVWQDMMGLRRGKGPRFVKRYADLAGIMG 264

Query: 265 RAAMQYAEEVASAVFPAEEHCF 286
            AA +YA EV    FP  EH F
Sbjct: 265 DAAREYAAEVRGHRFPGPEHSF 286


>sp|Q47R98|PANB_THEFY Tax_Id=269800 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Thermobifida
           fusca]
          Length = 280

 Score =  290 bits (741), Expect = 2e-76
 Identities = 151/263 (57%), Positives = 183/263 (69%), Gaps = 2/263 (0%)

Query: 25  KIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSA 84
           ++  + L   K  G +W MLTAYD  TAR+FDEAGIPVLLVGDSAA VV+GYD+T+PV+ 
Sbjct: 18  RVTVQDLAAAKERGERWPMLTAYDALTARIFDEAGIPVLLVGDSAAMVVFGYDSTIPVTL 77

Query: 85  DELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVA 144
           D+++PL   V R    ALVVADLPFGSY+ GP  AL  A R MKEGGA AVKLEGG RV 
Sbjct: 78  DDMIPLTAAVSRATKRALVVADLPFGSYQAGPEQALESAARLMKEGGAQAVKLEGGHRVI 137

Query: 145 EQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGD-AEQTXXXXXXXXXXXXXXXXM 203
            Q+  L +AGIPVM HIG TPQSVN LGG+RVQGR  + AE                  +
Sbjct: 138 AQVEALVSAGIPVMGHIGLTPQSVNVLGGYRVQGRSEEAAEALLSDAKELERAGVFSVVL 197

Query: 204 EMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGEL 263
           E VP  +  +IT +LT+PTIGIGAG + DAQVLVWQDMAGLS  +VA+FVK YA++A +L
Sbjct: 198 ECVPARVGAEITRQLTVPTIGIGAGPDTDAQVLVWQDMAGLSP-RVAKFVKSYANLAEQL 256

Query: 264 RRAAMQYAEEVASAVFPAEEHCF 286
           R AA  +AEEV +  FP E+H +
Sbjct: 257 RDAATSFAEEVVAGTFPDEQHSY 279


>tr|C4LHZ4|C4LHZ4_CORK4 Tax_Id=645127 SubName: Full=Ketopantoate
           hydroxymethyltransferase; EC=2.1.2.11;[Corynebacterium
           kroppenstedtii]
          Length = 285

 Score =  290 bits (741), Expect = 2e-76
 Identities = 150/277 (54%), Positives = 184/277 (66%), Gaps = 1/277 (0%)

Query: 11  ADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAA 70
           A P         R K R  HL + K E  +WAMLTAYD++TAR+FD+A IPVLLVGDSAA
Sbjct: 3   AHPDAPQQSEKPRRKTRIHHLDQFKRESKRWAMLTAYDFTTARIFDDADIPVLLVGDSAA 62

Query: 71  NVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEG 130
           NVVYGY +T  ++ +EL+PL   VVRGA HALVVADLPFG+YE     A+A A R +   
Sbjct: 63  NVVYGYSSTTAITMEELIPLAGAVVRGAPHALVVADLPFGAYEQSDEYAIANAVRMVHGS 122

Query: 131 GAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXX 190
           GA  VK+EGG+R+A +I  +T AGI VMAHIGFTPQSV+SLGGFRVQGRG  AEQ     
Sbjct: 123 GADMVKIEGGERIAPRIRAITQAGIAVMAHIGFTPQSVSSLGGFRVQGRGSGAEQLSRDA 182

Query: 191 XXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSG-KV 249
                       +EMVP E+A +IT +L IPTIGIGAG   D Q+LVWQDMA + +G + 
Sbjct: 183 KAVCEAGASAVVLEMVPKEIAREITEELPIPTIGIGAGAGTDGQILVWQDMAAMPAGRRT 242

Query: 250 ARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
             FV+++  I  ELR AA +Y + VA   FP  +H F
Sbjct: 243 PSFVEEFGQIGQELRDAARRYRDRVAEGTFPDADHAF 279


>tr|C1DI17|C1DI17_AZOVD Tax_Id=322710 SubName:
           Full=3-methyl-2-oxobutanoate
           hydroxymethyltransferase;[Azotobacter vinelandii]
          Length = 278

 Score =  289 bits (739), Expect = 3e-76
 Identities = 141/264 (53%), Positives = 185/264 (70%)

Query: 23  RTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPV 82
           + ++R  +L+++KA+G KWAMLTAYD  TA +F+EAGIPVLLVGDSA+N VYG ++T+ V
Sbjct: 15  KARVRIPYLKELKAQGRKWAMLTAYDMYTAAIFEEAGIPVLLVGDSASNNVYGNESTLTV 74

Query: 83  SADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQR 142
           + DEL+PLVR V +     LV+ADLPFGSY+  P      A RFMKE GAHAVKLEGG  
Sbjct: 75  TVDELIPLVRAVAKATHRPLVIADLPFGSYQASPEQCFHTAVRFMKEAGAHAVKLEGGIE 134

Query: 143 VAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXXXXXXXXXXXXXX 202
           +  Q+  L  +GIPVMAHIGFTPQ  + LGG+R+QGRG +A++                 
Sbjct: 135 MLPQVRKLATSGIPVMAHIGFTPQYEHQLGGYRIQGRGDEAQRLIDAALALEAAGAFALL 194

Query: 203 MEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGE 262
           +EMVP ++A  I+  ++IPT+GIGAG  CDAQVLVWQDMAGL +G++ RFVK+YAD+   
Sbjct: 195 IEMVPGDVAAAISRAVSIPTVGIGAGNQCDAQVLVWQDMAGLRTGRLPRFVKRYADMRAV 254

Query: 263 LRRAAMQYAEEVASAVFPAEEHCF 286
           L  AA  +A +V +  FP +EH F
Sbjct: 255 LAAAARDFAADVEAGAFPGQEHTF 278


>tr|C2ASR8|C2ASR8_TSUPA Tax_Id=521096 SubName: Full=Ketopantoate
           hydroxymethyltransferase; EC=2.1.2.11;[Tsukamurella
           paurometabola DSM 20162]
          Length = 286

 Score =  289 bits (739), Expect = 3e-76
 Identities = 153/287 (53%), Positives = 189/287 (65%), Gaps = 2/287 (0%)

Query: 1   MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGI 60
           MSE  +   G+ P +       R K+R  HL  +KA G KWAMLT+YDY TA +FDEAG+
Sbjct: 1   MSETPLYGSGSGPDSDPQARPPRKKVRIHHLADLKARGEKWAMLTSYDYMTASIFDEAGV 60

Query: 61  PVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAAL 120
             LL+GDSAAN VYG+D+T+P+  D +  +V  V RG  +ALVVAD+PF SYE  P  A 
Sbjct: 61  TALLIGDSAANTVYGFDSTLPMELDVMAAMVAAVRRGTKYALVVADMPFASYEESPEQAY 120

Query: 121 AVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRG 180
             A   MK  GA AVKLEGG+ +A  I  L   GIPVMAHIGFTPQSVN+LGG RVQGR 
Sbjct: 121 RSAATLMK-AGAEAVKLEGGEHMAPTIEFLQRRGIPVMAHIGFTPQSVNTLGGNRVQGRN 179

Query: 181 GD-AEQTXXXXXXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQ 239
            + AE+                 +EMVP+ +A ++T +++IPTIGIGAG +CD QVLVWQ
Sbjct: 180 DETAEKIRTDAKAVDAAGAFSVVLEMVPSAVAAEVTAEISIPTIGIGAGKDCDGQVLVWQ 239

Query: 240 DMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           DM+GL+ G+VARFVK+YA+I  EL R A  Y  EVAS  FP  EH F
Sbjct: 240 DMSGLNRGRVARFVKRYANIGDELLRGAQNYVAEVASGDFPGPEHGF 286


>sp|A0JVB5|PANB_ARTS2 Tax_Id=290399 (panB)RecName:
           Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
           EC=2.1.2.11; AltName: Full=Ketopantoate
           hydroxymethyltransferase; Short=KPHMT;[Arthrobacter sp.]
          Length = 301

 Score =  287 bits (735), Expect = 8e-76
 Identities = 150/276 (54%), Positives = 186/276 (67%), Gaps = 2/276 (0%)

Query: 11  ADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAA 70
           A PS ++ + + R  IRT HLQ+ K +G  +AMLTAY+  TA +FDEAGI VLLVGDSA+
Sbjct: 28  ATPSDTAKKPVAR--IRTHHLQQAKDKGEHFAMLTAYEQYTAEIFDEAGIEVLLVGDSAS 85

Query: 71  NVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEG 130
           N V+G +T++PV+ DELLPL R V R A  ALVVADLPFGSYE     A+A   RF+KEG
Sbjct: 86  NNVFGNETSLPVTVDELLPLCRAVARSAKRALVVADLPFGSYEVSAEQAVATGVRFLKEG 145

Query: 131 GAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTXXXX 190
            AHAVK+EGG+  A+ +  +  AGIPVMAHIGFTPQS +SLGG+RVQGRG DA++     
Sbjct: 146 LAHAVKIEGGKFYADTVRAMVQAGIPVMAHIGFTPQSEHSLGGYRVQGRGDDAQRLIDDA 205

Query: 191 XXXXXXXXXXXXMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVA 250
                       MEMVP   A  +   + +PT+GIGAG     QVLVWQDMAGL  GK+A
Sbjct: 206 VALAEAGAFSVLMEMVPAATAAAVDAAIAVPTVGIGAGNTTTGQVLVWQDMAGLRGGKMA 265

Query: 251 RFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286
           +FVKQYAD+   L  AA  Y ++V +  FP  EH F
Sbjct: 266 KFVKQYADLRTSLSNAAKAYGDDVRTGQFPGPEHSF 301


  Database: Amellifera_nr
    Posted date:  Jan 15, 2010  5:10 AM
  Number of letters in database: 3,808,957,724
  Number of sequences in database:  11,153,314
  
Lambda     K      H
   0.318    0.132    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 11153314
Number of Hits to DB: 1,960,870,218
Number of extensions: 76250465
Number of successful extensions: 218503
Number of sequences better than 10.0: 1594
Number of HSP's gapped: 217257
Number of HSP's successfully gapped: 1595
Length of query: 286
Length of database: 3,808,957,724
Length adjustment: 136
Effective length of query: 150
Effective length of database: 2,292,107,020
Effective search space: 343816053000
Effective search space used: 343816053000
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 79 (35.0 bits)