BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= ML1685c (485 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,153,314 sequences; 3,808,957,724 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|B8ZS12|B8ZS12_MYCLB Tax_Id=561304 (leuC)SubName: Full=3-isopr... 954 0.0 sp|O33123|LEUC_MYCLE Tax_Id=1769 (leuC)RecName: Full=3-isopropyl... 936 0.0 sp|Q73VI7|LEUC_MYCPA Tax_Id=1770 (leuC)RecName: Full=3-isopropyl... 832 0.0 sp|A0QJB7|LEUC_MYCA1 Tax_Id=243243 (leuC)RecName: Full=3-isoprop... 832 0.0 sp|B2HII1|LEUC_MYCMM Tax_Id=216594 (leuC)RecName: Full=3-isoprop... 822 0.0 sp|O53237|LEUC_MYCTU Tax_Id=1773 (leuC)RecName: Full=3-isopropyl... 820 0.0 sp|A5U6Z9|LEUC_MYCTA Tax_Id=419947 (leuC)RecName: Full=3-isoprop... 820 0.0 tr|C6DW61|C6DW61_MYCTK Tax_Id=478434 SubName: Full=3-isopropylma... 820 0.0 tr|A5WRP1|A5WRP1_MYCTF Tax_Id=336982 SubName: Full=3-isopropylma... 820 0.0 tr|A4KKP4|A4KKP4_MYCTU Tax_Id=395095 SubName: Full=3-isopropylma... 820 0.0 tr|A2VLV9|A2VLV9_MYCTU Tax_Id=348776 SubName: Full=3-isopropylma... 820 0.0 sp|C1AGA3|LEUC_MYCBT Tax_Id=561275 (leuC)RecName: Full=3-isoprop... 818 0.0 sp|A1KMY2|LEUC_MYCBP Tax_Id=410289 (leuC)RecName: Full=3-isoprop... 818 0.0 sp|Q7TXH6|LEUC_MYCBO Tax_Id=1765 (leuC)RecName: Full=3-isopropyl... 818 0.0 sp|A0PPZ6|LEUC_MYCUA Tax_Id=362242 (leuC)RecName: Full=3-isoprop... 814 0.0 sp|A1T700|LEUC_MYCVP Tax_Id=350058 (leuC)RecName: Full=3-isoprop... 811 0.0 tr|A0QUY9|A0QUY9_MYCS2 Tax_Id=246196 (leuC)SubName: Full=3-isopr... 804 0.0 sp|A4TE23|LEUC_MYCGI Tax_Id=350054 (leuC)RecName: Full=3-isoprop... 802 0.0 sp|A3PXR2|LEUC_MYCSJ Tax_Id=164757 (leuC)RecName: Full=3-isoprop... 788 0.0 sp|Q1BAQ4|LEUC_MYCSS Tax_Id=164756 (leuC)RecName: Full=3-isoprop... 788 0.0 sp|A1UEA8|LEUC_MYCSK Tax_Id=189918 (leuC)RecName: Full=3-isoprop... 788 0.0 sp|B1MDQ1|LEUC_MYCA9 Tax_Id=561007 (leuC)RecName: Full=3-isoprop... 784 0.0 sp|Q5YRY0|LEUC_NOCFA Tax_Id=37329 (leuC)RecName: Full=3-isopropy... 779 0.0 tr|C1B2N0|C1B2N0_RHOOB Tax_Id=632772 (leuC)SubName: Full=3-isopr... 772 0.0 tr|Q0S2G4|Q0S2G4_RHOSR Tax_Id=101510 (leuC2)SubName: Full=3-isop... 765 0.0 tr|C3JSK4|C3JSK4_RHOER Tax_Id=596309 (leuC)SubName: Full=3-isopr... 763 0.0 tr|C0ZXN1|C0ZXN1_RHOE4 Tax_Id=234621 (leuC)SubName: Full=3-isopr... 760 0.0 tr|D0LC33|D0LC33_9ACTO Tax_Id=526226 SubName: Full=3-isopropylma... 754 0.0 tr|C7MXF5|C7MXF5_SACVD Tax_Id=471857 SubName: Full=3-isopropylma... 754 0.0 tr|C6WG49|C6WG49_ACTMD Tax_Id=446462 SubName: Full=3-isopropylma... 742 0.0 tr|C2AUC8|C2AUC8_TSUPA Tax_Id=521096 SubName: Full=3-isopropylma... 739 0.0 sp|A4FMP2|LEUC_SACEN Tax_Id=405948 (leuC)RecName: Full=3-isoprop... 728 0.0 tr|C1YHU3|C1YHU3_NOCDA Tax_Id=446468 SubName: Full=3-isopropylma... 718 0.0 tr|A7DWG1|A7DWG1_STRCL Tax_Id=1901 (leuC)SubName: Full=Putative ... 717 0.0 tr|B0REY2|B0REY2_CLAMS Tax_Id=31964 (leuC)SubName: Full=3-isopro... 717 0.0 sp|Q47SA3|LEUC_THEFY Tax_Id=269800 (leuC)RecName: Full=3-isoprop... 716 0.0 sp|A6W7Q7|LEUC_KINRD Tax_Id=266940 (leuC)RecName: Full=3-isoprop... 714 0.0 tr|B5H064|B5H064_STRCL Tax_Id=443255 SubName: Full=3-isopropylma... 714 0.0 sp|A0LVA3|LEUC_ACIC1 Tax_Id=351607 (leuC)RecName: Full=3-isoprop... 714 0.0 tr|C5CAC8|C5CAC8_MICLC Tax_Id=465515 SubName: Full=3-isopropylma... 714 0.0 tr|A5CQN2|A5CQN2_CLAM3 Tax_Id=443906 (leuC)SubName: Full=LeuC pr... 713 0.0 tr|C8XEL9|C8XEL9_NAKMY Tax_Id=479431 SubName: Full=3-isopropylma... 710 0.0 tr|C7QH22|C7QH22_CATAD Tax_Id=479433 SubName: Full=3-isopropylma... 709 0.0 tr|B5GIX6|B5GIX6_9ACTO Tax_Id=465543 SubName: Full=3-isopropylma... 708 0.0 tr|C2AAA6|C2AAA6_THECU Tax_Id=471852 SubName: Full=3-isopropylma... 707 0.0 tr|C9KIL2|C9KIL2_9MICO Tax_Id=446469 SubName: Full=3-isopropylma... 706 0.0 tr|C9N9V0|C9N9V0_9ACTO Tax_Id=591167 SubName: Full=3-isopropylma... 706 0.0 sp|Q6AFK7|LEUC_LEIXX Tax_Id=59736 (leuC)RecName: Full=3-isopropy... 705 0.0 tr|C0W2R0|C0W2R0_9ACTO Tax_Id=525246 (leuC)SubName: Full=3-isopr... 704 0.0 tr|B4V596|B4V596_9ACTO Tax_Id=465541 SubName: Full=3-isopropylma... 703 0.0 >tr|B8ZS12|B8ZS12_MYCLB Tax_Id=561304 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit;[Mycobacterium leprae] Length = 485 Score = 954 bits (2467), Expect = 0.0 Identities = 472/485 (97%), Positives = 473/485 (97%) Query: 1 LEMDNERKQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAF 60 +EMDNERKQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAF Sbjct: 1 MEMDNERKQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAF 60 Query: 61 DGLRLAGRWVRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMG 120 DGLRLAGRWVRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMG Sbjct: 61 DGLRLAGRWVRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMG 120 Query: 121 DIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLR 180 DIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLR Sbjct: 121 DIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLR 180 Query: 181 PFKTMAVTVDGRLPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICN 240 PFKTMAVTVDGRLPAGVT GTGGGQGYVLEYRGSVIESMSMEGRMTICN Sbjct: 181 PFKTMAVTVDGRLPAGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICN 240 Query: 241 MSIEAGARAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDA 300 MSIEAGARAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDA Sbjct: 241 MSIEAGARAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDA 300 Query: 301 TSLSPFVTWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDA 360 TSLSPFVTWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDA Sbjct: 301 TSLSPFVTWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDA 360 Query: 361 VFVGSCTNGRIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQ 420 VFVGSCTNGRIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQ Sbjct: 361 VFVGSCTNGRIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQ 420 Query: 421 WRQPGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSA 480 WRQPGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSA Sbjct: 421 WRQPGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSA 480 Query: 481 PADLN 485 PADLN Sbjct: 481 PADLN 485 >sp|O33123|LEUC_MYCLE Tax_Id=1769 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium leprae] Length = 476 Score = 936 bits (2420), Expect = 0.0 Identities = 463/476 (97%), Positives = 464/476 (97%) Query: 10 VGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRW 69 +GGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRW Sbjct: 1 MGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRW 60 Query: 70 VRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHV 129 VRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHV Sbjct: 61 VRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHV 120 Query: 130 VGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTV 189 VGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTV Sbjct: 121 VGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTV 180 Query: 190 DGRLPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARA 249 DGRLPAGVT GTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARA Sbjct: 181 DGRLPAGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARA 240 Query: 250 GMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTW 309 GMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTW Sbjct: 241 GMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTW 300 Query: 310 GTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNG 369 GTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNG Sbjct: 301 GTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNG 360 Query: 370 RIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMC 429 RIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMC Sbjct: 361 RIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMC 420 Query: 430 LGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 LGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN Sbjct: 421 LGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 476 >sp|Q73VI7|LEUC_MYCPA Tax_Id=1770 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium paratuberculosis] Length = 476 Score = 832 bits (2150), Expect = 0.0 Identities = 411/475 (86%), Positives = 430/475 (90%), Gaps = 4/475 (0%) Query: 11 GGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWV 70 G PRTLAEKVWDDHVVV+G PDLIYIDLHLVHEVTSPQAFDGLRLAGR V Sbjct: 6 GTTATPRTLAEKVWDDHVVVSGGANE----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPV 61 Query: 71 RRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVV 130 RRPDLT+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFGVRL+PMGD EQGIVHVV Sbjct: 62 RRPDLTLATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHVV 121 Query: 131 GPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVD 190 GPQLGLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VD Sbjct: 122 GPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVD 181 Query: 191 GRLPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAG 250 G LPAGVT GTGGGQG+V+EYRGS IES+SMEGRMT+CNMSIEAGARAG Sbjct: 182 GELPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAG 241 Query: 251 MVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWG 310 M+APD+TTYEFLRDRPHAP G QWDAA+ YWQQLRTD AVFDTEVYLDA SLSPFVTWG Sbjct: 242 MIAPDDTTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEVYLDAASLSPFVTWG 301 Query: 311 TNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGR 370 TNPGQGVPLAA+VPDPELM DD RQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGR Sbjct: 302 TNPGQGVPLAAAVPDPELMTDDAERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGR 361 Query: 371 IEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCL 430 IEDLR+VADVLRG KVA GVRML+VPGSMRVRAQAEAEGLGE+F AGA+WRQ GCSMCL Sbjct: 362 IEDLRVVADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCL 421 Query: 431 GMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 GMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT SAPADL+ Sbjct: 422 GMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLD 476 >sp|A0QJB7|LEUC_MYCA1 Tax_Id=243243 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium avium] Length = 476 Score = 832 bits (2149), Expect = 0.0 Identities = 410/475 (86%), Positives = 430/475 (90%), Gaps = 4/475 (0%) Query: 11 GGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWV 70 G PRTLAEKVWDDHVVV+G PDLIYIDLHLVHEVTSPQAFDGLRLAGR V Sbjct: 6 GTTATPRTLAEKVWDDHVVVSGGANE----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPV 61 Query: 71 RRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVV 130 RRPDLT+ATEDHNVPT+DIDKPIADPVSR QVETLRRNCAEFGVRL+PMGD EQGIVHVV Sbjct: 62 RRPDLTLATEDHNVPTIDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHVV 121 Query: 131 GPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVD 190 GPQLGLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VD Sbjct: 122 GPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVD 181 Query: 191 GRLPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAG 250 G LPAGVT GTGGGQG+V+EYRGS IES+SMEGRMT+CNMSIEAGARAG Sbjct: 182 GELPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAG 241 Query: 251 MVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWG 310 M+APD+TTYEFLRDRPHAP G QWDAA+ YWQQLRTD AVFDTEVYLDA SLSPFVTWG Sbjct: 242 MIAPDDTTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEVYLDAASLSPFVTWG 301 Query: 311 TNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGR 370 TNPGQGVPLAA+VPDPELM DD RQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGR Sbjct: 302 TNPGQGVPLAAAVPDPELMTDDAERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGR 361 Query: 371 IEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCL 430 IEDLR+VADVLRG KVA GVRML+VPGSMRVRAQAEAEGLGE+F AGA+WRQ GCSMCL Sbjct: 362 IEDLRVVADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCL 421 Query: 431 GMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 GMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT SAPADL+ Sbjct: 422 GMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLD 476 >sp|B2HII1|LEUC_MYCMM Tax_Id=216594 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium marinum] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 406/472 (86%), Positives = 429/472 (90%), Gaps = 4/472 (0%) Query: 14 RKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRP 73 R+ RTLAEKVWDDHVVV+G+ + PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP Sbjct: 6 REARTLAEKVWDDHVVVSGR----NEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRP 61 Query: 74 DLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 133 DLT+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD+EQGIVHVVGPQ Sbjct: 62 DLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQ 121 Query: 134 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 193 LGLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRL Sbjct: 122 LGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRL 181 Query: 194 PAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 253 PAGV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVA Sbjct: 182 PAGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVA 241 Query: 254 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 313 PDETTYE+LR+RPHAPTG QWDAA+ YWQQLRTD AVFDTEV+LDA LSPFVTWGTNP Sbjct: 242 PDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNP 301 Query: 314 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 373 GQGVPL A+VPDPEL+ DD RQAAEKALAYMDL PG MRDIAVDAVFVGSCTNGRIED Sbjct: 302 GQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIED 361 Query: 374 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 433 LR+VA+VLRG KVA GVRMLIVPGSMRVRAQAE EGLGE+F AGA+WRQ GCSMCLGMN Sbjct: 362 LRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMN 421 Query: 434 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT SAPADLN Sbjct: 422 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 >sp|O53237|LEUC_MYCTU Tax_Id=1773 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium tuberculosis] Length = 473 Score = 820 bits (2117), Expect = 0.0 Identities = 406/471 (86%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MRDIAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|A5U6Z9|LEUC_MYCTA Tax_Id=419947 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium tuberculosis] Length = 473 Score = 820 bits (2117), Expect = 0.0 Identities = 406/471 (86%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MRDIAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|C6DW61|C6DW61_MYCTK Tax_Id=478434 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis] Length = 473 Score = 820 bits (2117), Expect = 0.0 Identities = 406/471 (86%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MRDIAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|A5WRP1|A5WRP1_MYCTF Tax_Id=336982 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis] Length = 473 Score = 820 bits (2117), Expect = 0.0 Identities = 406/471 (86%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MRDIAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|A4KKP4|A4KKP4_MYCTU Tax_Id=395095 SubName: Full=3-isopropylmalate dehydratase (Large subunit) leuC;[Mycobacterium tuberculosis str. Haarlem] Length = 473 Score = 820 bits (2117), Expect = 0.0 Identities = 406/471 (86%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MRDIAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|A2VLV9|A2VLV9_MYCTU Tax_Id=348776 SubName: Full=3-isopropylmalate dehydratase (Large subunit) leuC;[Mycobacterium tuberculosis C] Length = 473 Score = 820 bits (2117), Expect = 0.0 Identities = 406/471 (86%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MRDIAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|C1AGA3|LEUC_MYCBT Tax_Id=561275 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 818 bits (2113), Expect = 0.0 Identities = 405/471 (85%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MR+IAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|A1KMY2|LEUC_MYCBP Tax_Id=410289 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 818 bits (2113), Expect = 0.0 Identities = 405/471 (85%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MR+IAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|Q7TXH6|LEUC_MYCBO Tax_Id=1765 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 818 bits (2113), Expect = 0.0 Identities = 405/471 (85%), Positives = 427/471 (90%), Gaps = 4/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEK+WDDH+VV+G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGC----APDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDID+PIADPVSR QVETLRRNCAEFG+RLH MGDIEQGIVHVVGPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRLP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETTY FLR RPHAPTG QWD A+ YWQ+LRTD AVFDTEVYLDA SLSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPLAA+VPDP+LM DD RQAAEKALAYMDLRPGT MR+IAVDAVFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VA+VLRG KVADGVRMLIVPGSMRVRAQAEAEGLGEIF AGAQWRQ GCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 DQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGT S+PADLN Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|A0PPZ6|LEUC_MYCUA Tax_Id=362242 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium ulcerans] Length = 473 Score = 814 bits (2102), Expect = 0.0 Identities = 402/472 (85%), Positives = 427/472 (90%), Gaps = 4/472 (0%) Query: 14 RKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRP 73 R+ RTLAEKVWDDHVVV+G+ + PDLIYIDLH VHEVTSPQAFDGLRLAGR VRRP Sbjct: 6 REARTLAEKVWDDHVVVSGR----NEAPDLIYIDLHQVHEVTSPQAFDGLRLAGRPVRRP 61 Query: 74 DLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 133 DLT+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD+EQGIVHVVGPQ Sbjct: 62 DLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQ 121 Query: 134 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 193 LGLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPL PFKTMAV VDG+L Sbjct: 122 LGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLWPFKTMAVNVDGQL 181 Query: 194 PAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 253 PAGV+ GTGGGQG+V+EY+GS IES+SMEGRMTICNMSIEAGARAGMVA Sbjct: 182 PAGVSAKDIILALIAKIGTGGGQGHVIEYQGSAIESLSMEGRMTICNMSIEAGARAGMVA 241 Query: 254 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 313 PDETTYE+LR+RPHAPTG QWDAA+ YWQQLRTD AVFDTEV+LDA LSPFVTWGTNP Sbjct: 242 PDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNP 301 Query: 314 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 373 GQGVPL A+VPDPEL+ DD RQAAEKALAYMDL PG MRDIAVDAVFVGSCTNGRIED Sbjct: 302 GQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIED 361 Query: 374 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 433 LR+VA+VLRG KVA GVRMLIVPGSMRVRAQAE EGLGE+F AGA+WRQ GCSMCLGMN Sbjct: 362 LRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMN 421 Query: 434 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT SAPADLN Sbjct: 422 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 >sp|A1T700|LEUC_MYCVP Tax_Id=350058 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium vanbaalenii] Length = 481 Score = 811 bits (2095), Expect = 0.0 Identities = 391/470 (83%), Positives = 425/470 (90%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEKVW DHVVVAG G R PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRPD Sbjct: 6 QPRTLAEKVWSDHVVVAGTGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 65 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD+EQGIVH++GPQL Sbjct: 66 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHIIGPQL 125 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDG+LP Sbjct: 126 GLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGQLP 185 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS IES+SMEGRMT+CNMSIEAGARAGM+AP Sbjct: 186 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGMIAP 245 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETT+EFLR RPHAP G +WDAAVA W+QLRTD+ A FDTE+Y+DA++LSPFVTWGTNPG Sbjct: 246 DETTFEFLRGRPHAPKGAEWDAAVAVWRQLRTDEGAQFDTEIYIDASTLSPFVTWGTNPG 305 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPL+ VPDPELM D+ RQAAEKALAYMDLR GTPMR I VD VFVGSCTNGRIEDL Sbjct: 306 QGVPLSDPVPDPELMFDEAERQAAEKALAYMDLRAGTPMRQIPVDTVFVGSCTNGRIEDL 365 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VAD+LRG +VAD VRML+VPGSMRVRAQAE+EGLGEIF AGA+WRQ GCSMCLGMNP Sbjct: 366 RVVADILRGRRVADNVRMLVVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNP 425 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 DQLAPGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT S+PADL Sbjct: 426 DQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADL 475 >tr|A0QUY9|A0QUY9_MYCS2 Tax_Id=246196 (leuC)SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Mycobacterium smegmatis] Length = 484 Score = 804 bits (2076), Expect = 0.0 Identities = 389/470 (82%), Positives = 423/470 (90%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 KPRTLAEKVWDDHVV G+G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRPD Sbjct: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPT+DIDKPIADPVSR QVETLRRNC EFG+RLHPMGD EQGIVH++GPQL Sbjct: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMT+VCGDSHTSTHGAFGAIAMGIGTSE+EHV+ATQTL L+PFKTMAV VDG LP Sbjct: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GV+ GTGGGQG+V+EYRGS I S+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETT+EFL+ RPHAP G WDAAVA W +LRTD+ A FDTEVY+DA++LSPFVTWGTNPG Sbjct: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGVPL+ +VPDPEL++D+ ARQAAEKALAYMDLRPGTPMRDIAVD VFVGSCTNGRIEDL Sbjct: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R+VADVLRG KVADGVRMLIVPGSMRVRAQAE+EGL +IF AGAQWRQ GCSMCLGMNP Sbjct: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 DQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG ++PADL Sbjct: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 >sp|A4TE23|LEUC_MYCGI Tax_Id=350054 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium gilvum] Length = 481 Score = 802 bits (2072), Expect = 0.0 Identities = 390/472 (82%), Positives = 420/472 (88%) Query: 13 ARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRR 72 A +PRTLAEKVW DHVVV+G G R PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 4 ANQPRTLAEKVWSDHVVVSGSGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 63 Query: 73 PDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGP 132 PDLT+ATEDHNVPTVDIDKPIADPVSR QVETLRRNC EFG+RLHPMGD+EQGIVH++GP Sbjct: 64 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDVEQGIVHIIGP 123 Query: 133 QLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGR 192 QLGLTQPG T+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDG Sbjct: 124 QLGLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGE 183 Query: 193 LPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMV 252 LP GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGM+ Sbjct: 184 LPPGVSAKDVILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMI 243 Query: 253 APDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTN 312 APDETT+EFL+ RPHAP G WDAAV W+ LRTD+ A FDTEVY+DA SLSPFVTWGTN Sbjct: 244 APDETTFEFLKGRPHAPQGADWDAAVEAWKLLRTDEGAQFDTEVYIDAASLSPFVTWGTN 303 Query: 313 PGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIE 372 PGQGVPL+ SVPDPE++ D+ R A EKALAYMDLRPGTPMR+I VDAVFVGSCTNGRIE Sbjct: 304 PGQGVPLSDSVPDPEMIFDEGERSAVEKALAYMDLRPGTPMREIPVDAVFVGSCTNGRIE 363 Query: 373 DLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGM 432 DLR+VADVLRG VAD VRML+VPGSMRVRAQAEAEGLGEIF AGA+WRQ GCSMCLGM Sbjct: 364 DLRVVADVLRGRTVADDVRMLVVPGSMRVRAQAEAEGLGEIFTAAGAEWRQAGCSMCLGM 423 Query: 433 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 NPDQLAPGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT S+PADL Sbjct: 424 NPDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADL 475 >sp|A3PXR2|LEUC_MYCSJ Tax_Id=164757 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 788 bits (2036), Expect = 0.0 Identities = 382/470 (81%), Positives = 417/470 (88%) Query: 16 PRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDL 75 PRT+AEKVW DHVV G G R PDLIYIDLHLVHEVTSPQAFDGLRLA R VRRPDL Sbjct: 7 PRTMAEKVWADHVVAHGTGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVRRPDL 66 Query: 76 TVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLG 135 T+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD EQGIVH++GPQLG Sbjct: 67 TIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIGPQLG 126 Query: 136 LTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPA 195 LTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPF+TMAV VDG LP Sbjct: 127 LTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDGELPP 186 Query: 196 GVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPD 255 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAPD Sbjct: 187 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPD 246 Query: 256 ETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQ 315 +TT+EFLR RPHAPTG WDAAV W+QLRTD A FDTEV+LDA LSPFVTWGTNPGQ Sbjct: 247 DTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGTNPGQ 306 Query: 316 GVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLR 375 GVPL+ +VPDPEL++D+ RQAAEKAL YM L+ GT MRD+AVD VFVGSCTNGRIEDLR Sbjct: 307 GVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRIEDLR 366 Query: 376 LVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPD 435 +VADVLRG +VADG+RML+VPGSMRVRAQAE+EGL IFI AGA+WRQ GCSMCLGMNPD Sbjct: 367 VVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLGMNPD 426 Query: 436 QLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 QL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT S+PADL+ Sbjct: 427 QLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLS 476 >sp|Q1BAQ4|LEUC_MYCSS Tax_Id=164756 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 788 bits (2034), Expect = 0.0 Identities = 382/470 (81%), Positives = 417/470 (88%) Query: 16 PRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDL 75 PRT+AEKVW DHVV G G R PDLIYIDLHLVHEVTSPQAFDGLRLA R VRRPDL Sbjct: 7 PRTMAEKVWADHVVAHGIGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVRRPDL 66 Query: 76 TVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLG 135 T+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD EQGIVH++GPQLG Sbjct: 67 TIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIGPQLG 126 Query: 136 LTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPA 195 LTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPF+TMAV VDG LP Sbjct: 127 LTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDGELPP 186 Query: 196 GVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPD 255 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAPD Sbjct: 187 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPD 246 Query: 256 ETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQ 315 +TT+EFLR RPHAPTG WDAAV W+QLRTD A FDTEV+LDA LSPFVTWGTNPGQ Sbjct: 247 DTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGTNPGQ 306 Query: 316 GVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLR 375 GVPL+ +VPDPEL++D+ RQAAEKAL YM L+ GT MRD+AVD VFVGSCTNGRIEDLR Sbjct: 307 GVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRIEDLR 366 Query: 376 LVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPD 435 +VADVLRG +VADG+RML+VPGSMRVRAQAE+EGL IFI AGA+WRQ GCSMCLGMNPD Sbjct: 367 VVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLGMNPD 426 Query: 436 QLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 QL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT S+PADL+ Sbjct: 427 QLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLS 476 >sp|A1UEA8|LEUC_MYCSK Tax_Id=189918 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 788 bits (2034), Expect = 0.0 Identities = 382/470 (81%), Positives = 417/470 (88%) Query: 16 PRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDL 75 PRT+AEKVW DHVV G G R PDLIYIDLHLVHEVTSPQAFDGLRLA R VRRPDL Sbjct: 7 PRTMAEKVWADHVVAHGIGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVRRPDL 66 Query: 76 TVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLG 135 T+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD EQGIVH++GPQLG Sbjct: 67 TIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIGPQLG 126 Query: 136 LTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPA 195 LTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPF+TMAV VDG LP Sbjct: 127 LTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDGELPP 186 Query: 196 GVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPD 255 GV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVAPD Sbjct: 187 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPD 246 Query: 256 ETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQ 315 +TT+EFLR RPHAPTG WDAAV W+QLRTD A FDTEV+LDA LSPFVTWGTNPGQ Sbjct: 247 DTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGTNPGQ 306 Query: 316 GVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLR 375 GVPL+ +VPDPEL++D+ RQAAEKAL YM L+ GT MRD+AVD VFVGSCTNGRIEDLR Sbjct: 307 GVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRIEDLR 366 Query: 376 LVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPD 435 +VADVLRG +VADG+RML+VPGSMRVRAQAE+EGL IFI AGA+WRQ GCSMCLGMNPD Sbjct: 367 VVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLGMNPD 426 Query: 436 QLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 QL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT S+PADL+ Sbjct: 427 QLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLS 476 >sp|B1MDQ1|LEUC_MYCA9 Tax_Id=561007 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium abscessus] Length = 480 Score = 784 bits (2024), Expect = 0.0 Identities = 380/471 (80%), Positives = 411/471 (87%) Query: 14 RKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRP 73 ++PRTLAEKVWD HVVV G G + R PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP Sbjct: 5 QQPRTLAEKVWDSHVVVRGTGEGEAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRQVRRP 64 Query: 74 DLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 133 DLT+ATEDHNVPT+DIDKPIADPVSR QVETLR+NC EFG+RLHPMGD EQGIVHVVGPQ Sbjct: 65 DLTIATEDHNVPTIDIDKPIADPVSRTQVETLRKNCEEFGIRLHPMGDAEQGIVHVVGPQ 124 Query: 134 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 193 LGLTQPG T+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPF+TMA+ +DG L Sbjct: 125 LGLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAINIDGSL 184 Query: 194 PAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 253 P GVT GTGGGQGYVLEYRG +E MSME RMT+CNMSIEAGARAGMVA Sbjct: 185 PTGVTSKDVILAVIAKIGTGGGQGYVLEYRGQAVEEMSMEARMTMCNMSIEAGARAGMVA 244 Query: 254 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 313 PDETTY +L+DRPHAP G+ WDAAVA W LRTD+ A FD EV++DA++L+PFVTWGTNP Sbjct: 245 PDETTYAYLKDRPHAPKGQLWDAAVAEWDSLRTDEGAQFDAEVHIDASTLTPFVTWGTNP 304 Query: 314 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 373 GQGVPL A VPDPELM D+ R AAEKAL YMDL PGTPMR+I VD VFVGSCTNGRIED Sbjct: 305 GQGVPLGADVPDPELMADEEERLAAEKALTYMDLTPGTPMREIPVDTVFVGSCTNGRIED 364 Query: 374 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 433 LR VADVLR KVA GV MLIVPGSMRVRAQAE+EGLGEIF AGAQWRQ GCSMCLGMN Sbjct: 365 LRAVADVLRDRKVAAGVTMLIVPGSMRVRAQAESEGLGEIFAAAGAQWRQAGCSMCLGMN 424 Query: 434 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 PDQL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG S+PADL Sbjct: 425 PDQLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLSSPADL 475 >sp|Q5YRY0|LEUC_NOCFA Tax_Id=37329 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Nocardia farcinica] Length = 474 Score = 779 bits (2011), Expect = 0.0 Identities = 372/473 (78%), Positives = 413/473 (87%) Query: 13 ARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRR 72 A +PRTLAEKVW++HVV G+G R PDLIYIDLHLVHEVTSPQAFDGLR AGR VRR Sbjct: 2 ADRPRTLAEKVWEEHVVARGEGEGASREPDLIYIDLHLVHEVTSPQAFDGLRAAGRPVRR 61 Query: 73 PDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGP 132 PDLT+ATEDHNVPTVDIDKPIADP+SR QVETLRRNCAEFG+RLHPMGD+EQGIVHVVGP Sbjct: 62 PDLTIATEDHNVPTVDIDKPIADPISRTQVETLRRNCAEFGIRLHPMGDLEQGIVHVVGP 121 Query: 133 QLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGR 192 QLGLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTL LRPFKTMA+ +DG+ Sbjct: 122 QLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLSLRPFKTMAINIDGQ 181 Query: 193 LPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMV 252 LP GVT GTGGGQGYVLEYRG + +MSME RMT+CNMSIEAGARAGM+ Sbjct: 182 LPPGVTSKDVILAVIAQIGTGGGQGYVLEYRGEAVRAMSMEARMTMCNMSIEAGARAGMI 241 Query: 253 APDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTN 312 APDE TYEFL+ RPHAP G WDAAVA W LRTD+ AVFD EV++DA+SLSPFVTWGTN Sbjct: 242 APDEVTYEFLKGRPHAPKGADWDAAVAAWDALRTDEGAVFDAEVHIDASSLSPFVTWGTN 301 Query: 313 PGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIE 372 PGQG PL+A+VPDP D+ AR+AA KAL YMDL PGTP+R++AVD VFVGSCTNGRIE Sbjct: 302 PGQGAPLSATVPDPADFADETAREAAAKALRYMDLTPGTPLREVAVDTVFVGSCTNGRIE 361 Query: 373 DLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGM 432 DLR A++L+G +VA+GVRML+VPGSMRVRAQAE EGLGEIF AGA+WRQ GCSMCLGM Sbjct: 362 DLRAAAEILKGRRVAEGVRMLVVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGM 421 Query: 433 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 NPDQL PG+RCA+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+PADL+ Sbjct: 422 NPDQLEPGQRCASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADLD 474 >tr|C1B2N0|C1B2N0_RHOOB Tax_Id=632772 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus opacus] Length = 473 Score = 772 bits (1994), Expect = 0.0 Identities = 376/472 (79%), Positives = 411/472 (87%), Gaps = 4/472 (0%) Query: 13 ARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRR 72 A K RTLAEKVWDDHVVV G+G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR +RR Sbjct: 5 AEKARTLAEKVWDDHVVVRGEGDN----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRR 60 Query: 73 PDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGP 132 PDLT+ATEDHNVPTVDIDKPIADPVS+ QV+TLRRNC EFGVRLHPMG+I+QGIVHVVGP Sbjct: 61 PDLTIATEDHNVPTVDIDKPIADPVSKTQVDTLRRNCEEFGVRLHPMGNIDQGIVHVVGP 120 Query: 133 QLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGR 192 QLGLTQPGMT+VCGDSHTSTHGAFGAIAMGIGTSE+EHV+ATQTL LRPF+TMA+TVDG Sbjct: 121 QLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLRPFRTMAITVDGE 180 Query: 193 LPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMV 252 LP GVT GTGGGQGYVLEYRG I MSME RMTICNMSIEAGARAGM+ Sbjct: 181 LPEGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKMSMEARMTICNMSIEAGARAGMI 240 Query: 253 APDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTN 312 APDE TYEF++ RPHAP G WDAAVA W+QL+TD+ AVFD EV++DA++L+PFVTWGTN Sbjct: 241 APDEITYEFIKGRPHAPKGADWDAAVAAWEQLKTDEGAVFDNEVHIDASALTPFVTWGTN 300 Query: 313 PGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIE 372 PGQG+PL +VPDPE ++D+ R AAEKAL YM L GTP+R++A+D VFVGSCTNGRIE Sbjct: 301 PGQGLPLGEAVPDPEQIVDESERHAAEKALTYMGLEAGTPLREVAIDTVFVGSCTNGRIE 360 Query: 373 DLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGM 432 DLR VADVLRG VADGVRMLIVPGSMRVRAQAE EGLGEIF AGA+WRQ GCSMCLGM Sbjct: 361 DLRAVADVLRGRHVADGVRMLIVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGM 420 Query: 433 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 NPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT SAP DL Sbjct: 421 NPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPTDL 472 >tr|Q0S2G4|Q0S2G4_RHOSR Tax_Id=101510 (leuC2)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus sp.] Length = 500 Score = 765 bits (1976), Expect = 0.0 Identities = 372/472 (78%), Positives = 409/472 (86%), Gaps = 4/472 (0%) Query: 13 ARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRR 72 A K RTLAEKVWDDHVVV G+G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR +RR Sbjct: 32 AEKARTLAEKVWDDHVVVRGEGDN----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRR 87 Query: 73 PDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGP 132 PDLT+ATEDHNVPTVDIDKPIADPVS+ QV+TLRRNC EFGVRLHPMG+I+QGIVHVVGP Sbjct: 88 PDLTIATEDHNVPTVDIDKPIADPVSKTQVDTLRRNCEEFGVRLHPMGNIDQGIVHVVGP 147 Query: 133 QLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGR 192 QLGLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHV+ATQTL LRPF+TMA+TVDG Sbjct: 148 QLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFRTMAITVDGE 207 Query: 193 LPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMV 252 LP GVT GTGGGQGYVLEYRG I MSME RMT+CNMSIEAGARAGM+ Sbjct: 208 LPDGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKMSMEARMTVCNMSIEAGARAGMI 267 Query: 253 APDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTN 312 APDE TYEF++ RPHAP G WDAAV W+QL+TD+ AVFD EV++DA+SL+PFVTWGTN Sbjct: 268 APDEITYEFIKGRPHAPKGADWDAAVEAWEQLKTDEGAVFDNEVHIDASSLTPFVTWGTN 327 Query: 313 PGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIE 372 PGQG+PL +VP+P ++D+ R AAEKAL YM L GTP+R++A+D VFVGSCTNGRIE Sbjct: 328 PGQGLPLGEAVPNPAEIVDESERHAAEKALTYMGLEAGTPLREVAIDTVFVGSCTNGRIE 387 Query: 373 DLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGM 432 DLR VADVLRG VADGVRMLIVPGSMRVRAQAE EGLGEIF AGA+WRQ GCSMCLGM Sbjct: 388 DLRAVADVLRGRHVADGVRMLIVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGM 447 Query: 433 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 NPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT SAP DL Sbjct: 448 NPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPTDL 499 >tr|C3JSK4|C3JSK4_RHOER Tax_Id=596309 (leuC)SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Rhodococcus erythropolis SK121] Length = 473 Score = 763 bits (1970), Expect = 0.0 Identities = 370/472 (78%), Positives = 410/472 (86%), Gaps = 4/472 (0%) Query: 13 ARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRR 72 A+K RTLAEKVWDDHVVV G+G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR +RR Sbjct: 5 AQKARTLAEKVWDDHVVVKGEG----QDPDLIYIDLHLVHEVTSPQAFDGLRLAGRQLRR 60 Query: 73 PDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGP 132 PDLT+ATEDHNVPT+DIDKPIADPVS+ QV+TLRRNC EFGVRLH MGD++QGIVHVVGP Sbjct: 61 PDLTIATEDHNVPTIDIDKPIADPVSKTQVDTLRRNCEEFGVRLHRMGDLDQGIVHVVGP 120 Query: 133 QLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGR 192 QLGLTQPG T+VCGDSHTSTHGAFGA+AMGIGTSE+EHV+ATQTL LRPFKTMA+TVDG Sbjct: 121 QLGLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFKTMAITVDGE 180 Query: 193 LPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMV 252 LP GVT GTGGGQGYVLEYRG I +SME RMTICNMSIEAGARAGM+ Sbjct: 181 LPPGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKLSMEARMTICNMSIEAGARAGMI 240 Query: 253 APDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTN 312 APDETTYEF++ RPHAP+G +WD AVA W+ L+TD+ A FD EV++DA++L+PFVTWGTN Sbjct: 241 APDETTYEFIKGRPHAPSGAEWDEAVAAWELLKTDEGAEFDNEVHIDASALTPFVTWGTN 300 Query: 313 PGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIE 372 PGQG PL VPDPEL++D+ RQAAEKAL YM L G P+RD++VD VFVGSCTNGRIE Sbjct: 301 PGQGAPLGDRVPDPELIVDESERQAAEKALTYMGLDAGMPLRDVSVDTVFVGSCTNGRIE 360 Query: 373 DLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGM 432 DLR VA+VL G VA+GVRMLIVPGSMRVRAQAE+EGLGEIF AGA+WRQ GCSMCLGM Sbjct: 361 DLRAVAEVLEGRHVAEGVRMLIVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGM 420 Query: 433 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 NPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT SAPADL Sbjct: 421 NPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPADL 472 >tr|C0ZXN1|C0ZXN1_RHOE4 Tax_Id=234621 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus erythropolis] Length = 473 Score = 760 bits (1963), Expect = 0.0 Identities = 370/472 (78%), Positives = 409/472 (86%), Gaps = 4/472 (0%) Query: 13 ARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRR 72 A+K RTLAEKVWDDHVVV G+G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR +RR Sbjct: 5 AQKARTLAEKVWDDHVVVKGEG----QDPDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRR 60 Query: 73 PDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGP 132 PDLT+ATEDHNVPT+DIDKPIADPVS+ QV+TLRRNC EFGVRLH MGD++QGIVHVVGP Sbjct: 61 PDLTIATEDHNVPTIDIDKPIADPVSKTQVDTLRRNCEEFGVRLHRMGDLDQGIVHVVGP 120 Query: 133 QLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGR 192 QLGLTQPG T+VCGDSHTSTHGAFGA+AMGIGTSE+EHV+ATQTL LRPFKTMA+TVDG Sbjct: 121 QLGLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFKTMAITVDGE 180 Query: 193 LPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMV 252 LP GVT GTGGGQGYVLEYRG I +SME RMTICNMSIEAGARAGM+ Sbjct: 181 LPPGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKLSMEARMTICNMSIEAGARAGMI 240 Query: 253 APDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTN 312 APDETTYEF++ RPHAP+G +WD AVA W+ L+TD+ A FD EV++DA++L+PFVTWGTN Sbjct: 241 APDETTYEFIKGRPHAPSGAEWDEAVAAWELLKTDEGAEFDNEVHIDASALTPFVTWGTN 300 Query: 313 PGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIE 372 PGQG PL VPDPEL++D+ RQAAEKAL YM L G +RD+AVD VFVGSCTNGRIE Sbjct: 301 PGQGAPLGDRVPDPELIVDESERQAAEKALTYMGLDAGMALRDVAVDTVFVGSCTNGRIE 360 Query: 373 DLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGM 432 DLR VA+VL G VA+GVRMLIVPGSMRVRAQAE+EGLGEIF AGA+WRQ GCSMCLGM Sbjct: 361 DLRAVAEVLEGRHVAEGVRMLIVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGM 420 Query: 433 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 NPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT SAPADL Sbjct: 421 NPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPADL 472 >tr|D0LC33|D0LC33_9ACTO Tax_Id=526226 SubName: Full=3-isopropylmalate dehydratase, large subunit;[Gordonia bronchialis DSM 43247] Length = 477 Score = 754 bits (1948), Expect = 0.0 Identities = 370/471 (78%), Positives = 405/471 (85%), Gaps = 1/471 (0%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQD-RGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRP 73 KPRTLAEKVW+DHVVV G+ + PDLIYIDLHLVHEVTSPQAF+GLRLAGR VRRP Sbjct: 7 KPRTLAEKVWEDHVVVPGEADASGAQNPDLIYIDLHLVHEVTSPQAFEGLRLAGRPVRRP 66 Query: 74 DLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 133 DLT+ATEDHNVPT+DI PIAD VSR QVETLRRNCAEFG+RLHPMGD EQGIVHVVGPQ Sbjct: 67 DLTIATEDHNVPTLDIFSPIADEVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHVVGPQ 126 Query: 134 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 193 LGLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTL LRPFKTMA+TVDG L Sbjct: 127 LGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLSLRPFKTMAITVDGEL 186 Query: 194 PAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 253 P+GVT GTGGGQGYVLEYRG IE +SME RMTICNMSIEAGARAGM+A Sbjct: 187 PSGVTSKDLILAVIAKIGTGGGQGYVLEYRGPAIEKLSMEARMTICNMSIEAGARAGMIA 246 Query: 254 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 313 PD+ TY+FL+ RP+APTG WDAAV YW LRTD A FD EV++DA++L+PFVTWGTNP Sbjct: 247 PDQVTYDFLKGRPNAPTGADWDAAVQYWDSLRTDPGAEFDAEVHIDASALTPFVTWGTNP 306 Query: 314 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 373 GQG PL A VPDP M D+ A AA KAL YMDL PG P+RDI VD VFVGSCTNGRIED Sbjct: 307 GQGAPLGAVVPDPADMGDENASTAASKALEYMDLTPGMPLRDIKVDTVFVGSCTNGRIED 366 Query: 374 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 433 LR VA++L+G KVA+G+RMLIVPGSMRVRAQAE EGLG+IF AGA+WRQ GCSMCLGMN Sbjct: 367 LRAVAEILKGRKVAEGMRMLIVPGSMRVRAQAEDEGLGDIFEHAGAEWRQAGCSMCLGMN 426 Query: 434 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 PDQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT S+P DL Sbjct: 427 PDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPDDL 477 >tr|C7MXF5|C7MXF5_SACVD Tax_Id=471857 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Saccharomonospora viridis] Length = 471 Score = 754 bits (1946), Expect = 0.0 Identities = 365/472 (77%), Positives = 408/472 (86%), Gaps = 4/472 (0%) Query: 14 RKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRP 73 ++ RTLAEKVWD HVV G+G PDL+YIDLHLVHEVTSPQAFDGLRLAGR VRRP Sbjct: 4 KRGRTLAEKVWDAHVVRRGEGAE----PDLLYIDLHLVHEVTSPQAFDGLRLAGRKVRRP 59 Query: 74 DLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 133 DLT+ATEDHNVPT ID PIADPVSR QVETLRRNC EFG+RLHPMGD EQGIVHV+GPQ Sbjct: 60 DLTIATEDHNVPTTGIDLPIADPVSRTQVETLRRNCEEFGIRLHPMGDDEQGIVHVIGPQ 119 Query: 134 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 193 LGLTQPGMT+VCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLP+RPFKTMAV VDG+L Sbjct: 120 LGLTQPGMTVVCGDSHTSTHGAFGAMAFGIGTSEVEHVLATQTLPMRPFKTMAVNVDGQL 179 Query: 194 PAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 253 GVT GTGGGQG+V+EYRGS IE++SME RMTICNMSIEAGARAGM+A Sbjct: 180 RPGVTAKDIILAVIAKIGTGGGQGHVIEYRGSTIEALSMEARMTICNMSIEAGARAGMIA 239 Query: 254 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 313 PDETT+ +L+DRPHAP G WDAA+A W++LRTDDDAVFDTEV+LDA+ L+PFVTWGTNP Sbjct: 240 PDETTFAYLKDRPHAPQGADWDAALAEWRELRTDDDAVFDTEVHLDASELTPFVTWGTNP 299 Query: 314 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 373 GQG+PL+ SVPDPE M D+ R AAEKAL+YMDL+PGTP+R+IAVD VF+GSCTNGR+ED Sbjct: 300 GQGLPLSESVPDPEQMTDETERLAAEKALSYMDLKPGTPLREIAVDTVFLGSCTNGRLED 359 Query: 374 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 433 LR A+VL+G KVADGVRML+VPGSMRVR AE EGL E+F AGA+WR GCSMCLGMN Sbjct: 360 LRAAAEVLKGRKVADGVRMLVVPGSMRVRKAAEEEGLHEVFTEAGAEWRAAGCSMCLGMN 419 Query: 434 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 PDQL PGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+P DL+ Sbjct: 420 PDQLKPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPEDLD 471 >tr|C6WG49|C6WG49_ACTMD Tax_Id=446462 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Actinosynnema mirum] Length = 472 Score = 742 bits (1916), Expect = 0.0 Identities = 362/468 (77%), Positives = 398/468 (85%), Gaps = 4/468 (0%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RTLAEKVW+ HVV G G PDL+YIDLHL+HEVTSPQAFDGLRLAGR +RRPDLT Sbjct: 3 RTLAEKVWEAHVVRHGSGAE----PDLLYIDLHLLHEVTSPQAFDGLRLAGRRLRRPDLT 58 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHNVPTVDI+ PIADPVSR QVETLRRNCAEFGVRLHPMGD EQGIVHVVGPQLGL Sbjct: 59 IATEDHNVPTVDIELPIADPVSRTQVETLRRNCAEFGVRLHPMGDAEQGIVHVVGPQLGL 118 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPGMT+VCGDSHTSTHGAFGA+A GIGTSE+EHV+ATQTLPLRPFKTMA+ V+G L G Sbjct: 119 TQPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQTLPLRPFKTMAINVEGSLRPG 178 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGYVLEYRGS I ++SME RMT+CNMSIEAGARAGM+APD+ Sbjct: 179 VTAKDVILAVIAKIGTGGGQGYVLEYRGSAISALSMEARMTVCNMSIEAGARAGMIAPDQ 238 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+++++ RPHAP+G WDAAV YW L TD+ A FD EV LDA L+PFVTWGTNPGQG Sbjct: 239 TTFDYIKGRPHAPSGADWDAAVEYWSTLATDEGAEFDAEVTLDADELTPFVTWGTNPGQG 298 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 +PL ASVPDPE + D+ R AAEKAL+YM L GTP+RDI VD VF+GSCTNGRIEDLR Sbjct: 299 LPLGASVPDPEAIADENERVAAEKALSYMGLEAGTPLRDIRVDTVFLGSCTNGRIEDLRA 358 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 ADVLRGH VADGVRML+VPGSMRVRAQAE EGL E+F AGA+WRQ GCSMCLGMNPDQ Sbjct: 359 AADVLRGHHVADGVRMLVVPGSMRVRAQAETEGLHEVFQAAGAEWRQAGCSMCLGMNPDQ 418 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 L PGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+PADL Sbjct: 419 LKPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 466 >tr|C2AUC8|C2AUC8_TSUPA Tax_Id=521096 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Tsukamurella paurometabola DSM 20162] Length = 481 Score = 739 bits (1909), Expect = 0.0 Identities = 362/470 (77%), Positives = 398/470 (84%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRT+AEKVWD HVVV G+G R PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRPD Sbjct: 2 QPRTMAEKVWDQHVVVKGEGEGASREPDLIYIDLHLVHEVTSPQAFDGLRLAGRTVRRPD 61 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHNVPT + +PIAD VSR QVETLRRNCAEFGVRLH MGD EQGIVHV+GPQL Sbjct: 62 LTIATEDHNVPTDTLVQPIADEVSRTQVETLRRNCAEFGVRLHSMGDGEQGIVHVMGPQL 121 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPGMT+VCGDSHTSTHGAFGAIAMGIGTSE+EHVLATQTL L+PFKTMA+ V G L Sbjct: 122 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVLATQTLALKPFKTMAINVSGELQ 181 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GVT GTGGGQGYVLEYRGS IE +SME RMTICNMSIEAGARAGM+AP Sbjct: 182 PGVTSKDLILAIIAKIGTGGGQGYVLEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAP 241 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 D+ TY+++R R HAP G+ WD AVA W LRTD+ AVFD E+ +D +L+PFVTWGTNPG Sbjct: 242 DQITYDYIRGREHAPQGELWDEAVAAWDALRTDEGAVFDAEIDIDGGALTPFVTWGTNPG 301 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QG+PL+ SVPDP D R+ A KAL YM L PGTP+R+IAVD VFVGSCTNGRIEDL Sbjct: 302 QGLPLSGSVPDPASFGSDGERETAAKALQYMGLEPGTPLREIAVDTVFVGSCTNGRIEDL 361 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R VA++LRG KVADGVRML+VPGSMRVRAQAE EGLG+IF+ AGA+WRQ GCSMCLGMNP Sbjct: 362 RAVAEILRGRKVADGVRMLVVPGSMRVRAQAEEEGLGQIFLDAGAEWRQAGCSMCLGMNP 421 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 DQLAPGER A+TSNRNFEGRQGKG RTHLVSPAVAAATAVRGT S+PADL Sbjct: 422 DQLAPGERSASTSNRNFEGRQGKGSRTHLVSPAVAAATAVRGTLSSPADL 471 >sp|A4FMP2|LEUC_SACEN Tax_Id=405948 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Saccharopolyspora erythraea] Length = 467 Score = 728 bits (1880), Expect = 0.0 Identities = 352/469 (75%), Positives = 392/469 (83%), Gaps = 4/469 (0%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 +TLAEKVW+ H+V G+GY PDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLT Sbjct: 3 KTLAEKVWEAHIVRRGEGYE----PDLLYIDLHLVHEVTSPQAFEGLRLAGRQVRRPDLT 58 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHNVPT ID PIADPVSR QV+TLRRNC EFG+RLHPMGD EQGIVHVVGPQLGL Sbjct: 59 LATEDHNVPTTGIDLPIADPVSRTQVDTLRRNCEEFGIRLHPMGDAEQGIVHVVGPQLGL 118 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPG T+VCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLPLRPFKTMA+ ++G L G Sbjct: 119 TQPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLRPFKTMAINIEGTLRPG 178 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGYVLEYRGS +E MSME RMT+CNMSIEAGARAGM+APDE Sbjct: 179 VTSKDVILAVIAKIGTGGGQGYVLEYRGSAVEKMSMEARMTMCNMSIEAGARAGMIAPDE 238 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+ +L+ RPHAP G +WDAAV YW+ LRTD+DA FD EV LDA L+PFVTWGTNPGQG Sbjct: 239 TTFAYLQGRPHAPEGTEWDAAVEYWKTLRTDEDAEFDAEVTLDADELTPFVTWGTNPGQG 298 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 +PL A +PDP + D+ R A EKAL YM L GTP+R++AVD VF+GSCTNGRIEDLR Sbjct: 299 LPLGARIPDPAAIADESERFATEKALDYMGLEAGTPLREVAVDTVFLGSCTNGRIEDLRA 358 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 ADVL+G KVA VRML+VPGSMRVR QAEAEGL E+F AGA+WR GCSMCLGMNPDQ Sbjct: 359 AADVLKGRKVASEVRMLVVPGSMRVRKQAEAEGLNEVFTAAGAEWRSAGCSMCLGMNPDQ 418 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 L PGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+P DL+ Sbjct: 419 LTPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPEDLD 467 >tr|C1YHU3|C1YHU3_NOCDA Tax_Id=446468 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] Length = 468 Score = 718 bits (1854), Expect = 0.0 Identities = 348/468 (74%), Positives = 397/468 (84%), Gaps = 5/468 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RT+AEKVW++HVV G PDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLT Sbjct: 3 RTMAEKVWEEHVVRRADGE-----PDLLYIDLHLVHEVTSPQAFEGLRLAGRSVRRPDLT 57 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHNVPT D+ PIADPVSR QVETLR+NC++FGVRLHPMGDIEQG+VHVVGPQLGL Sbjct: 58 IATEDHNVPTQDLLAPIADPVSRKQVETLRKNCSDFGVRLHPMGDIEQGVVHVVGPQLGL 117 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPGMTIVCGDSHTSTHGAFGA+A GIGTS++EHVLATQTLP+ PFKTMAVTV+G L G Sbjct: 118 TQPGMTIVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPMAPFKTMAVTVNGTLRPG 177 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 V+ GTGGGQGYV+EYRG IE++SME RMT+CNMSIEAGARAGM+APD+ Sbjct: 178 VSAKDVILAVIAKIGTGGGQGYVIEYRGEAIEALSMEARMTVCNMSIEAGARAGMIAPDQ 237 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT++++R R HAP G+ +DAAV +W+ LRTD+ AVFD EV LDA LSPFVTWGTNPGQG Sbjct: 238 TTFDYIRGRAHAPQGEDFDAAVEHWKSLRTDEGAVFDAEVVLDADELSPFVTWGTNPGQG 297 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 VPL ASVPDP D AR AAEKALAYMDL GTPMR+++VD VF+GSCTNGRIEDLR Sbjct: 298 VPLDASVPDPASFEDPSARAAAEKALAYMDLAAGTPMREVSVDTVFLGSCTNGRIEDLRA 357 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 A+++RG +VA+GVRML+VPGSMRV+ QA EGLG +F AGA+WR+ GCSMCLGMNPDQ Sbjct: 358 AAEIIRGRRVAEGVRMLVVPGSMRVKEQANEEGLGRVFEEAGAEWREAGCSMCLGMNPDQ 417 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 L PGER A+TSNRNFEGRQG+GGRTHLVSP VAAATAVRGT S+PADL Sbjct: 418 LKPGERSASTSNRNFEGRQGRGGRTHLVSPQVAAATAVRGTLSSPADL 465 >tr|A7DWG1|A7DWG1_STRCL Tax_Id=1901 (leuC)SubName: Full=Putative isopropylmalate isomerase large subunit;[Streptomyces clavuligerus] Length = 483 Score = 717 bits (1852), Expect = 0.0 Identities = 351/477 (73%), Positives = 393/477 (82%), Gaps = 5/477 (1%) Query: 8 KQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAG 67 + GG RTLAEKVWDDHVV +G PDL+YIDLHL+HEVTSPQAFDGLR++G Sbjct: 2 RPAGGKAMGRTLAEKVWDDHVVRRAEGE-----PDLLYIDLHLLHEVTSPQAFDGLRMSG 56 Query: 68 RWVRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIV 127 R VRR DLT+ATEDHN PT+DIDKPIADPVSR Q+ETLR+NCAEFGVRLHP+GD+EQG+V Sbjct: 57 RTVRRLDLTIATEDHNTPTLDIDKPIADPVSRAQLETLRKNCAEFGVRLHPLGDVEQGVV 116 Query: 128 HVVGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAV 187 HVVGPQLGLTQPG T+VCGDSHTSTHGAFGA+A GIGTS++EHVLATQTLPL +TMA+ Sbjct: 117 HVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAI 176 Query: 188 TVDGRLPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGA 247 TV+G LP GVT GTGGGQGY+LEYRG IE +SME RMTICNMSIEAGA Sbjct: 177 TVEGELPDGVTAKDLILAIIARIGTGGGQGYILEYRGPAIEKLSMESRMTICNMSIEAGA 236 Query: 248 RAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFV 307 RAGM+APDETT+ +L+DR HAP ++WDAAVAYW+ LR+DDDAVFD EV +DA +LSPFV Sbjct: 237 RAGMIAPDETTFAYLKDRDHAPRDEEWDAAVAYWKTLRSDDDAVFDAEVVIDAAALSPFV 296 Query: 308 TWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCT 367 TWGTNPGQG PL+ASVPDP D R AAEKAL YM L G P+RDI VD VFVGSCT Sbjct: 297 TWGTNPGQGAPLSASVPDPASYEDASERLAAEKALEYMGLAAGQPLRDITVDTVFVGSCT 356 Query: 368 NGRIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCS 427 NGRIEDLR A VL G KVADGVRML+VPGS+RV QA AEGL ++F AGA+WR GCS Sbjct: 357 NGRIEDLRSAATVLEGRKVADGVRMLVVPGSVRVSLQAVAEGLDKVFTAAGAEWRHAGCS 416 Query: 428 MCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 MCLGMNPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G ++PADL Sbjct: 417 MCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPPVAAATAVLGHLASPADL 473 >tr|B0REY2|B0REY2_CLAMS Tax_Id=31964 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Clavibacter michiganensis subsp. sepedonicus] Length = 493 Score = 717 bits (1851), Expect = 0.0 Identities = 346/468 (73%), Positives = 391/468 (83%), Gaps = 4/468 (0%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 +TLAEKVW DH+V G+ D PDL+YIDLHLVHEVTSPQAFDGLRLAGR VRRPDLT Sbjct: 9 KTLAEKVWADHLVAEGE----DGTPDLLYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 64 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHN PT+ ID+PIAD SR Q+ TLRRN EFG+RLH +GDIEQGIVHVVGPQLGL Sbjct: 65 IATEDHNTPTIGIDRPIADLTSRTQIHTLRRNAEEFGIRLHSLGDIEQGIVHVVGPQLGL 124 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 T PG+T+VCGDSHTSTHGAFGA+A GIGTSE+EHV+ATQTLPL+PFKTMAVTV+G L G Sbjct: 125 TMPGITVVCGDSHTSTHGAFGAMAFGIGTSEVEHVMATQTLPLQPFKTMAVTVEGTLRPG 184 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGYVLEYRGS I S+SMEGRMTICNMSIEAGARAGMVAPD+ Sbjct: 185 VTAKDIILAVIAQIGTGGGQGYVLEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDQ 244 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TTY++LR RPHAPTG WD AVAYW L TDDDAVFD EV+LDA +L PFVTWGTNPGQG Sbjct: 245 TTYDYLRGRPHAPTGADWDEAVAYWDTLATDDDAVFDAEVFLDADTLEPFVTWGTNPGQG 304 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 V L+ VPDP + D R AAE+ALAYMDL PGTPM++IAVD VF+GSCTN R+EDLR Sbjct: 305 VSLSEPVPDPAAVADPNERAAAERALAYMDLAPGTPMKEIAVDTVFIGSCTNSRVEDLRA 364 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 A+++RG A+GVR+++VPGS RVR +AEAEG+ ++F GA+WR GCSMCLGMNPDQ Sbjct: 365 AAEIVRGRTKAEGVRVMVVPGSARVRLEAEAEGIDKVFTDFGAEWRFAGCSMCLGMNPDQ 424 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 LAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGT S+P DL Sbjct: 425 LAPGERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSPWDL 472 >sp|Q47SA3|LEUC_THEFY Tax_Id=269800 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Thermobifida fusca] Length = 465 Score = 716 bits (1847), Expect = 0.0 Identities = 348/468 (74%), Positives = 394/468 (84%), Gaps = 5/468 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RT+AEKVW++HVV +G PDL+YIDLHL+HEVTSPQAF+GLRLA R +RRPDLT Sbjct: 3 RTMAEKVWEEHVVRRAEGE-----PDLLYIDLHLIHEVTSPQAFEGLRLANRKLRRPDLT 57 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHNVPT +I PIADPVSR QVETLR+N AEFGVRLHPMGDI+QGIVHV+GPQLGL Sbjct: 58 IATEDHNVPTENIFLPIADPVSRTQVETLRKNAAEFGVRLHPMGDIDQGIVHVIGPQLGL 117 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPGMTIVCGDSHTSTHGAFGA+A GIGTS++EHV+ATQTLP+ PFKTMAV V+G+L G Sbjct: 118 TQPGMTIVCGDSHTSTHGAFGALAFGIGTSQVEHVMATQTLPMTPFKTMAVNVEGKLKPG 177 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQG+V+EYRG I S+SME RMTICNMSIEAGARAGM+APD+ Sbjct: 178 VTAKDIILAVIAQIGTGGGQGHVIEYRGEAIRSLSMEARMTICNMSIEAGARAGMIAPDQ 237 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+++L+ RPHAP G+ WD AV YW+ L TD+ AVFD EV+L+A LSPFVTWGTNPGQG Sbjct: 238 TTFDYLKGRPHAPKGELWDQAVEYWKTLPTDEGAVFDKEVFLNADELSPFVTWGTNPGQG 297 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 VPL + VPDPE D V R AAEKALAYMDL+PGT MRDI +D VF+GSCTNGRIEDLR Sbjct: 298 VPLDSVVPDPESFTDPVERAAAEKALAYMDLKPGTRMRDIKIDTVFLGSCTNGRIEDLRA 357 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 A+VL+G KVADGVRML+VPGS RV+ QA AEGL EIF AGA+WR+ GCSMCLGMNPD Sbjct: 358 AAEVLKGRKVADGVRMLVVPGSQRVKQQAAAEGLDEIFKAAGAEWREAGCSMCLGMNPDT 417 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 L PGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+PADL Sbjct: 418 LKPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 465 >sp|A6W7Q7|LEUC_KINRD Tax_Id=266940 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Kineococcus radiotolerans] Length = 477 Score = 714 bits (1844), Expect = 0.0 Identities = 351/471 (74%), Positives = 387/471 (82%), Gaps = 7/471 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RTLAEKVWDDHVV GQ D PDL+YIDLHLVHEVTSPQAFDGLR AGR VRR DLT Sbjct: 3 RTLAEKVWDDHVVRKGQ----DGEPDLLYIDLHLVHEVTSPQAFDGLRAAGRPVRRLDLT 58 Query: 77 VATEDHNVPTVDIDKPIA---DPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 133 +ATEDHN PTVDID+P++ D S Q++TLR NCAEFGVRLHP+GD EQGIVHVVGPQ Sbjct: 59 IATEDHNTPTVDIDRPLSLLEDKTSAKQLQTLRENCAEFGVRLHPLGDAEQGIVHVVGPQ 118 Query: 134 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 193 LGLTQPGMT+VCGDSHTSTHGAFG++ MGIGTSE+EHVLATQTLPL+PFKTMA+TVDG L Sbjct: 119 LGLTQPGMTVVCGDSHTSTHGAFGSLGMGIGTSEVEHVLATQTLPLKPFKTMAITVDGTL 178 Query: 194 PAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 253 G T GTGGGQGYVLEYRG I ++SMEGRMTICNMSIEAGARAGMVA Sbjct: 179 KPGTTAKDVILAVIAEIGTGGGQGYVLEYRGEAIRNLSMEGRMTICNMSIEAGARAGMVA 238 Query: 254 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 313 PDETT+ +L RPHAP G WDAAV YW+ LRTDDDA FD EV LD ++L PFVTWGTNP Sbjct: 239 PDETTFAYLEGRPHAPQGADWDAAVEYWRTLRTDDDAEFDAEVVLDGSALEPFVTWGTNP 298 Query: 314 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 373 GQGVPL+ SVP+PE + DD RQ E+AL YM L GTPMRDIAVD VF+GSCTN RIED Sbjct: 299 GQGVPLSGSVPEPERIGDDGVRQGVERALEYMGLEGGTPMRDIAVDTVFIGSCTNSRIED 358 Query: 374 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 433 LR ADV+RG + AD VR+++VPGS +VR QAEAEG+ +F GA WR GCSMCLGMN Sbjct: 359 LRAAADVVRGRRKADSVRVMVVPGSAKVRLQAEAEGIDTVFKEFGADWRFAGCSMCLGMN 418 Query: 434 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 PDQLAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+PADL Sbjct: 419 PDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 469 >tr|B5H064|B5H064_STRCL Tax_Id=443255 SubName: Full=3-isopropylmalate dehydratase large subunit;[Streptomyces clavuligerus ATCC 27064] Length = 475 Score = 714 bits (1844), Expect = 0.0 Identities = 349/468 (74%), Positives = 390/468 (83%), Gaps = 5/468 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RTLAEKVWDDHVV +G PDL+YIDLHL+HEVTSPQAFDGLR++GR VRR DLT Sbjct: 3 RTLAEKVWDDHVVRRAEGE-----PDLLYIDLHLLHEVTSPQAFDGLRMSGRTVRRLDLT 57 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHN PT+DIDKPIADPVSR Q+ETLR+NCAEFGVRLHP+GD+EQG+VHVVGPQLGL Sbjct: 58 IATEDHNTPTLDIDKPIADPVSRAQLETLRKNCAEFGVRLHPLGDVEQGVVHVVGPQLGL 117 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPG T+VCGDSHTSTHGAFGA+A GIGTS++EHVLATQTLPL +TMA+TV+G LP G Sbjct: 118 TQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVEGELPDG 177 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGY+LEYRG IE +SME RMTICNMSIEAGARAGM+APDE Sbjct: 178 VTAKDLILAIIARIGTGGGQGYILEYRGPAIEKLSMESRMTICNMSIEAGARAGMIAPDE 237 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+ +L+DR HAP ++WDAAVAYW+ LR+DDDAVFD EV +DA +LSPFVTWGTNPGQG Sbjct: 238 TTFAYLKDRDHAPRDEEWDAAVAYWKTLRSDDDAVFDAEVVIDAAALSPFVTWGTNPGQG 297 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 PL+ASVPDP D R AAEKAL YM L G P+RDI VD VFVGSCTNGRIEDLR Sbjct: 298 APLSASVPDPASYEDASERLAAEKALEYMGLAAGQPLRDITVDTVFVGSCTNGRIEDLRS 357 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 A VL G KVADGVRML+VPGS+RV QA AEGL ++F AGA+WR GCSMCLGMNPDQ Sbjct: 358 AATVLEGRKVADGVRMLVVPGSVRVSLQAVAEGLDKVFTAAGAEWRHAGCSMCLGMNPDQ 417 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 LAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G ++PADL Sbjct: 418 LAPGERSASTSNRNFEGRQGKGGRTHLVSPPVAAATAVLGHLASPADL 465 >sp|A0LVA3|LEUC_ACIC1 Tax_Id=351607 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Acidothermus cellulolyticus] Length = 473 Score = 714 bits (1842), Expect = 0.0 Identities = 349/475 (73%), Positives = 392/475 (82%), Gaps = 5/475 (1%) Query: 11 GGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWV 70 G + RT+AEK+W++HVV G PDL+YIDLHL+HEVTSPQAFDGLRLAGR V Sbjct: 4 GTGVRGRTMAEKIWEEHVVRRADGE-----PDLLYIDLHLIHEVTSPQAFDGLRLAGRRV 58 Query: 71 RRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVV 130 RRPDLT+ATEDHNVPT DIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD EQGIVHV+ Sbjct: 59 RRPDLTIATEDHNVPTTDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDREQGIVHVI 118 Query: 131 GPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVD 190 GPQLGLTQPGMTIVCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLP KTMAVTVD Sbjct: 119 GPQLGLTQPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPQYKPKTMAVTVD 178 Query: 191 GRLPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAG 250 G L GVT GTGGGQG+V+EYRG I ++SME RMTICNMSIEAGARAG Sbjct: 179 GTLRPGVTSKDIILALIAKIGTGGGQGHVIEYRGEAIRALSMEARMTICNMSIEAGARAG 238 Query: 251 MVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWG 310 M+APD+TT+ +L RPHAP G+ W+AA+ YW+ L TD DAVFD EV LDA SLSP+VTWG Sbjct: 239 MIAPDDTTFAYLEGRPHAPKGRDWEAALEYWRSLPTDPDAVFDEEVLLDAGSLSPYVTWG 298 Query: 311 TNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGR 370 TNPGQG PL + VPDP D + R AAE+ALAYMDL+PGTP+R+I VD VF+GSCTNGR Sbjct: 299 TNPGQGAPLDSVVPDPATFSDPIERAAAERALAYMDLQPGTPLREIRVDTVFIGSCTNGR 358 Query: 371 IEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCL 430 IEDLR A VL+G KVA GVR+L+VPGSM V+AQAEAEGL IF AGA+WR GCSMCL Sbjct: 359 IEDLRAAASVLQGRKVAPGVRVLVVPGSMAVKAQAEAEGLDRIFRDAGAEWRNAGCSMCL 418 Query: 431 GMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 GMNPDQLAPG+R A+TSNRNFEGRQG+GGRTHLVSP VAAATAV G +AP+DL+ Sbjct: 419 GMNPDQLAPGQRSASTSNRNFEGRQGRGGRTHLVSPLVAAATAVAGHLAAPSDLD 473 >tr|C5CAC8|C5CAC8_MICLC Tax_Id=465515 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Micrococcus luteus] Length = 484 Score = 714 bits (1842), Expect = 0.0 Identities = 344/470 (73%), Positives = 391/470 (83%) Query: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 +PRTLAEKVWD+HVVV G+G R PDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPD Sbjct: 7 RPRTLAEKVWDEHVVVRGEGEGASRTPDLLYIDLHLVHEVTSPQAFEGLRLAGRPVRRPD 66 Query: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 LT+ATEDHN PT+DID+PIAD SR Q+ETLR NCAEFGVRLHP+GD EQGIVHVVGPQL Sbjct: 67 LTIATEDHNTPTLDIDQPIADATSRTQIETLRANCAEFGVRLHPLGDAEQGIVHVVGPQL 126 Query: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 GLTQPG+T+VCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLPL+PFKTMAVTVDG L Sbjct: 127 GLTQPGLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLKPFKTMAVTVDGTLR 186 Query: 195 AGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 GVT GTGGGQG+VLEYRG I ++SMEGRMTICNMSIEAGARAGMVAP Sbjct: 187 PGVTAKDIILAVIAKIGTGGGQGFVLEYRGEAIRNLSMEGRMTICNMSIEAGARAGMVAP 246 Query: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 DETT+ +L+ RPHAP G WDAAV +W+ L TD+ A FD EV +DA +L PFVTWGTNPG Sbjct: 247 DETTFAYLKGRPHAPVGADWDAAVEHWRTLATDEGAEFDAEVVIDADTLEPFVTWGTNPG 306 Query: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 QGV L +VP PE D VA++AA KAL+YMDL PGTPM+ + VD VF+GSCTN RIEDL Sbjct: 307 QGVSLNDAVPAPEDFADPVAQEAARKALSYMDLAPGTPMKQVEVDTVFMGSCTNSRIEDL 366 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R A+V+RG + A+G+R+++VPGS RVR QA EGL +F GA+WR GCSMCLGMNP Sbjct: 367 RAFAEVVRGRRKAEGLRVMVVPGSARVRLQAMDEGLDRVFEDFGAEWRFAGCSMCLGMNP 426 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 DQLAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATAV G ++P+DL Sbjct: 427 DQLAPGERCASTSNRNFEGRQGKGGRTHLVSPVVAAATAVLGRLASPSDL 476 >tr|A5CQN2|A5CQN2_CLAM3 Tax_Id=443906 (leuC)SubName: Full=LeuC protein; EC=4.2.1.33;[Clavibacter michiganensis subsp. michiganensis] Length = 489 Score = 713 bits (1840), Expect = 0.0 Identities = 345/468 (73%), Positives = 389/468 (83%), Gaps = 4/468 (0%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 +TLAEKVW DH+V G D PDL+YIDLHLVHEVTSPQAFDGLRLAGR VRRPDLT Sbjct: 5 KTLAEKVWADHLVAEGA----DGTPDLLYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 60 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHN PTV ID+PIAD SR Q+ TLR+N EFG+RLH +GDIEQGIVHVVGPQLGL Sbjct: 61 IATEDHNTPTVGIDQPIADLTSRTQIHTLRKNAEEFGIRLHSLGDIEQGIVHVVGPQLGL 120 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 T PG+T+VCGDSHTSTHGAFGA+A GIGTSE+EHV+ATQTLPL+PFKTMAVTV+G L G Sbjct: 121 TMPGITVVCGDSHTSTHGAFGAMAFGIGTSEVEHVMATQTLPLQPFKTMAVTVEGTLRPG 180 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGYVLEYRGS I S+SMEGRMTICNMSIEAGARAGMVAPD+ Sbjct: 181 VTAKDIILAVIAQIGTGGGQGYVLEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDQ 240 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TTY++L RPHAPTG WD AVAYW L TDDDAVFD EV+LDA +L PFVTWGTNPGQG Sbjct: 241 TTYDYLEGRPHAPTGADWDEAVAYWDTLATDDDAVFDAEVFLDADTLEPFVTWGTNPGQG 300 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 V L+ VPDP + D R AAE+ALAYMDL PGTPM++IAVD VF+GSCTN R+EDLR Sbjct: 301 VSLSEPVPDPAAVADPNERAAAERALAYMDLAPGTPMKEIAVDTVFIGSCTNSRVEDLRA 360 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 A+++RG A+GVR+++VPGS RVR +AEAEG+ ++F GA+WR GCSMCLGMNPDQ Sbjct: 361 AAEIVRGRTKAEGVRVMVVPGSARVRLEAEAEGIDKVFTDFGAEWRFAGCSMCLGMNPDQ 420 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 LAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGT S+P DL Sbjct: 421 LAPGERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSPWDL 468 >tr|C8XEL9|C8XEL9_NAKMY Tax_Id=479431 SubName: Full=3-isopropylmalate dehydratase, large subunit;[Nakamurella multipartita] Length = 486 Score = 710 bits (1833), Expect = 0.0 Identities = 353/477 (74%), Positives = 392/477 (82%), Gaps = 15/477 (3%) Query: 18 TLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLTV 77 TLAEKVW+ HVV A +G PDL+YIDLHLVHEVTSPQAFDGLR AGR VRRPDLT+ Sbjct: 4 TLAEKVWNAHVVHAAEGE-----PDLLYIDLHLVHEVTSPQAFDGLRQAGRPVRRPDLTL 58 Query: 78 ATEDHNVPT---VDIDKP-------IADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIV 127 ATEDHNVPT VD D I DPVSR QVETLR NCAEFGVRL PMGD EQGIV Sbjct: 59 ATEDHNVPTLFQVDADGGTRSRNLLIEDPVSRTQVETLRANCAEFGVRLFPMGDYEQGIV 118 Query: 128 HVVGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAV 187 HVVGPQLG+TQPGMTIVCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLPL+PFKTMA+ Sbjct: 119 HVVGPQLGITQPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLKPFKTMAI 178 Query: 188 TVDGRLPAGVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGA 247 TV+G L GVT GTGGGQGYVLEYRG I ++SMEGRMTICNMSIEAGA Sbjct: 179 TVEGTLAPGVTAKDIILAVIAKIGTGGGQGYVLEYRGEAIRALSMEGRMTICNMSIEAGA 238 Query: 248 RAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFV 307 RAGM+APDETT+ +++ R HAP G+ WD AV YW+ LRTDDDA FD EV LD ++L+PFV Sbjct: 239 RAGMIAPDETTFAYVQGRDHAPKGQDWDRAVEYWRSLRTDDDATFDAEVILDGSALTPFV 298 Query: 308 TWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCT 367 TWGTNPGQG+PL+ VPDPE M+DD R A EKAL+YMDL PGTP+R I VD VF+GSCT Sbjct: 299 TWGTNPGQGLPLSDVVPDPEAMVDDNERLATEKALSYMDLTPGTPLRQIHVDTVFLGSCT 358 Query: 368 NGRIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCS 427 NGRIEDLR AD+LRG ++ +RML+VPGSMRVRAQAE EGL ++F+ AGA+WR GCS Sbjct: 359 NGRIEDLRAAADILRGRRIDPTLRMLVVPGSMRVRAQAEEEGLDQVFLDAGAEWRSAGCS 418 Query: 428 MCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 MCLGMNPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+PADL Sbjct: 419 MCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 475 >tr|C7QH22|C7QH22_CATAD Tax_Id=479433 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Catenulispora acidiphila] Length = 468 Score = 709 bits (1830), Expect = 0.0 Identities = 342/470 (72%), Positives = 394/470 (83%), Gaps = 6/470 (1%) Query: 16 PRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDL 75 P TLAEKVW DHVV + G PDL+YIDLHL+HEVTSPQAFDGLR AGR VRRPDL Sbjct: 2 PHTLAEKVWADHVVRSADGE-----PDLLYIDLHLLHEVTSPQAFDGLRQAGRTVRRPDL 56 Query: 76 TVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLG 135 T+ATEDHN PT++IDKPIADPVSR+Q+ETLR+NCA+FGVR+H +GD +QGIVHVVGPQLG Sbjct: 57 TIATEDHNTPTLEIDKPIADPVSRLQIETLRKNCADFGVRIHSLGDAQQGIVHVVGPQLG 116 Query: 136 LTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPA 195 LTQPGMT+VCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLPL+PFKTMAVTV G L Sbjct: 117 LTQPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLKPFKTMAVTVTGALGE 176 Query: 196 GVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPD 255 GVT GTGGGQGYV+EYRG +E +SMEGRMT+CNMSIEAGARAGM+APD Sbjct: 177 GVTAKDVVLAVIAQIGTGGGQGYVIEYRGEAVEKLSMEGRMTVCNMSIEAGARAGMIAPD 236 Query: 256 ETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQ 315 ETT+ +L+ R HAP+G WDAAV YW+ LRT+D A FD EV +D +L+P+VTWGTNPGQ Sbjct: 237 ETTFAYLKGRAHAPSGADWDAAVEYWKTLRTEDGATFDAEVVIDGDALTPYVTWGTNPGQ 296 Query: 316 GVPLAASVPDPELMID-DVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 G+PL+ASVPDP+ +V + AA KAL YM L+ GTP+R+I VD VF+GSCTNGR+EDL Sbjct: 297 GLPLSASVPDPDKDFGAEVDKVAARKALEYMGLQAGTPLREIKVDTVFLGSCTNGRLEDL 356 Query: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 R A V++G +VADGVRML+VPGS RVR +AEAEGL E+F AGA+WR GCSMCLGMNP Sbjct: 357 RAAAAVIKGRQVADGVRMLVVPGSARVRLEAEAEGLHEVFTAAGAEWRFAGCSMCLGMNP 416 Query: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 DQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S+P+DL Sbjct: 417 DQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPSDL 466 >tr|B5GIX6|B5GIX6_9ACTO Tax_Id=465543 SubName: Full=3-isopropylmalate dehydratase large subunit;[Streptomyces sp. SPB74] Length = 473 Score = 708 bits (1828), Expect = 0.0 Identities = 345/468 (73%), Positives = 388/468 (82%), Gaps = 5/468 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RTLAEKVWDDHVV +G PDL+YIDLHL+HEVTSPQAFDGLR GR VRR DLT Sbjct: 3 RTLAEKVWDDHVVRRAEGE-----PDLLYIDLHLLHEVTSPQAFDGLRQNGRRVRRLDLT 57 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHN PT+DIDKPIADPVSR Q+ETLR+NCA+FGVRLHP+GD+EQG+VHVVGPQLGL Sbjct: 58 IATEDHNTPTLDIDKPIADPVSRAQLETLRKNCADFGVRLHPLGDVEQGVVHVVGPQLGL 117 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPG T+VCGDSHTSTHGAFGA+A GIGTS++EHVLATQTLPL +TMA+TV+G LPA Sbjct: 118 TQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVEGELPAD 177 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGY+LEYRG+ IE +SME RMTICNMSIEAGARAGM+APDE Sbjct: 178 VTAKDLILAVIAKIGTGGGQGYILEYRGAAIEKLSMESRMTICNMSIEAGARAGMIAPDE 237 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+ +L+DRPHAP G +WD AV+YW+ LRTD+DAVFD EV +D +SL+PFVTWGTNPGQG Sbjct: 238 TTFAYLKDRPHAPQGPEWDEAVSYWKTLRTDEDAVFDAEVVIDGSSLAPFVTWGTNPGQG 297 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 PL+A VPDP D AR AAEKAL YM L G P+R+I+VD VFVGSCTNGRIEDLR Sbjct: 298 APLSARVPDPASFDDPSARFAAEKALEYMGLAAGQPLREISVDTVFVGSCTNGRIEDLRA 357 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 ADVLRG VAD VRML+VPGS+RV QA EGL ++F AGA+WR GCSMCLGMNPDQ Sbjct: 358 AADVLRGRAVADDVRMLVVPGSVRVALQAVEEGLDKVFTEAGAEWRHAGCSMCLGMNPDQ 417 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 LAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G +PADL Sbjct: 418 LAPGERSASTSNRNFEGRQGKGGRTHLVSPKVAAATAVLGRLGSPADL 465 >tr|C2AAA6|C2AAA6_THECU Tax_Id=471852 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Thermomonospora curvata DSM 43183] Length = 468 Score = 707 bits (1824), Expect = 0.0 Identities = 344/468 (73%), Positives = 392/468 (83%), Gaps = 5/468 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RTLA+KV+D HVV +G PDL+YIDLHLVHEVTSPQAFDGLR+AGR VRRPDLT Sbjct: 6 RTLADKVYDAHVVRRAEGE-----PDLLYIDLHLVHEVTSPQAFDGLRMAGRKVRRPDLT 60 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHNVPT ++ PIADPVSR QVETLR+N AEFG+RLHPMGD QGIVHV+GPQLGL Sbjct: 61 IATEDHNVPTQNLLAPIADPVSRTQVETLRKNAAEFGIRLHPMGDEGQGIVHVIGPQLGL 120 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPGMT+VCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLP K MAVTV+G LP G Sbjct: 121 TQPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPQIKPKNMAVTVNGTLPVG 180 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQG+++EYRG I +SMEGRMT+CNMSIEAGARAGM+APDE Sbjct: 181 VTAKDLILAIIAKIGTGGGQGHIIEYRGEAIRGLSMEGRMTVCNMSIEAGARAGMIAPDE 240 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+ +L+ RPHAP G +WD AV YW+ LRTDDDAVFD EV +DA++L+P+VTWGTNPGQG Sbjct: 241 TTFAYLKGRPHAPKGAEWDKAVEYWKSLRTDDDAVFDKEVVIDASTLTPYVTWGTNPGQG 300 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 +PL+ SVPDP D + RQAAE+AL YM L PGTP+RDI +D VFVGSCTNGRIEDLR Sbjct: 301 LPLSESVPDPASFEDPIERQAAERALEYMGLTPGTPLRDIKIDTVFVGSCTNGRIEDLRA 360 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 VA+VL+G KVADGVRMLIVPGSM+V+AQA+ EGL EIF AGA+WR+ GCSMCL MNPD+ Sbjct: 361 VAEVLKGRKVADGVRMLIVPGSMKVKAQAQEEGLDEIFKAAGAEWREAGCSMCLAMNPDK 420 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 L+PGER A+TSNRNFEGRQG GGRTHLVSPAVAAATAV G +APADL Sbjct: 421 LSPGERSASTSNRNFEGRQGPGGRTHLVSPAVAAATAVTGRLTAPADL 468 >tr|C9KIL2|C9KIL2_9MICO Tax_Id=446469 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Sanguibacter keddieii DSM 10542] Length = 479 Score = 706 bits (1823), Expect = 0.0 Identities = 340/467 (72%), Positives = 387/467 (82%), Gaps = 4/467 (0%) Query: 18 TLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLTV 77 TLAEKVWD H+V G D PDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLT+ Sbjct: 4 TLAEKVWDAHLVRRGS----DGAPDLLYIDLHLVHEVTSPQAFEGLRLAGRPVRRPDLTI 59 Query: 78 ATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGLT 137 ATEDHN PT++ID PIAD SR Q++TLR N EFGVR+H +GD +QGIVHVVGPQLGLT Sbjct: 60 ATEDHNTPTLNIDLPIADLTSRTQIDTLRNNAKEFGVRIHSLGDADQGIVHVVGPQLGLT 119 Query: 138 QPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAGV 197 PG+T+VCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLPL PFKTMA+TVDG LP G Sbjct: 120 MPGLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLAPFKTMAITVDGALPEGS 179 Query: 198 TXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDET 257 T GTGGGQGYVLEYRG I S+SMEGRMTICNMSIEAGARAGM+APDET Sbjct: 180 TAKDIILAVIAKIGTGGGQGYVLEYRGEAIRSLSMEGRMTICNMSIEAGARAGMIAPDET 239 Query: 258 TYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQGV 317 T+E+L+ RPHAP G WDAAV YW+ LRTDDDA FDTEV L+A L PFVTWGTNPGQG+ Sbjct: 240 TFEYLKGRPHAPEGADWDAAVEYWKTLRTDDDATFDTEVVLEAADLEPFVTWGTNPGQGL 299 Query: 318 PLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRLV 377 PL+A+VP P + D+ R AE+A+ YM L PGTP+RDIA+D VF+GSCTNGRIEDLR V Sbjct: 300 PLSANVPVPSEIADENERVTAERAIEYMGLNPGTPLRDIAIDTVFIGSCTNGRIEDLRAV 359 Query: 378 ADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQL 437 A+++ G K AD +R+L+VPGS RVR QAEAEGL ++F+ GA+WR GCSMCLGMNPDQL Sbjct: 360 AEIVEGKKKADTLRVLVVPGSARVRLQAEAEGLDKVFLDFGAEWRNAGCSMCLGMNPDQL 419 Query: 438 APGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 APGER A+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGT S+P+DL Sbjct: 420 APGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSPSDL 466 >tr|C9N9V0|C9N9V0_9ACTO Tax_Id=591167 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Streptomyces flavogriseus ATCC 33331] Length = 474 Score = 706 bits (1822), Expect = 0.0 Identities = 346/469 (73%), Positives = 385/469 (82%), Gaps = 5/469 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RTLAEKVWDDHVV G PDL++IDLHL+HEVTSPQAFDGLR AGR VRR DLT Sbjct: 3 RTLAEKVWDDHVVRRADGE-----PDLLFIDLHLLHEVTSPQAFDGLRQAGRPVRRLDLT 57 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHN PT+DIDKPIADPVSR Q+ETLR+NCAEFGVRLHP+GD+EQG+VHVVGPQLGL Sbjct: 58 IATEDHNTPTLDIDKPIADPVSRAQLETLRKNCAEFGVRLHPLGDVEQGVVHVVGPQLGL 117 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPG T+VCGDSHTSTHGAFGA+A GIGTS++EHVLATQTLPL +TMA+TV+G LP Sbjct: 118 TQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVEGELPDS 177 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGY+LEYRGS IE +SME RMTICNMSIEAGARAGM+APDE Sbjct: 178 VTAKDLILAIIARIGTGGGQGYILEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDE 237 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+ +L+ R HAP GK WDAAV YW+ LRTDDDAVFD EV +D SL+PFVTWGTNPGQG Sbjct: 238 TTFAYLKGRDHAPEGKDWDAAVEYWKTLRTDDDAVFDAEVVIDGASLAPFVTWGTNPGQG 297 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 PL+A+VPDP D R AAEKAL YM L G P+R+I VD VFVGSCTNGRIEDLR Sbjct: 298 APLSANVPDPASYEDASERHAAEKALEYMGLTAGQPLREIGVDTVFVGSCTNGRIEDLRN 357 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 A VL G KVADGVRML+VPGS+RV QA EGL ++F AGA+WR GCSMCLGMNPDQ Sbjct: 358 AASVLEGRKVADGVRMLVVPGSVRVALQAVEEGLDKVFTAAGAEWRHAGCSMCLGMNPDQ 417 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 LAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G ++PADL+ Sbjct: 418 LAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLS 466 >sp|Q6AFK7|LEUC_LEIXX Tax_Id=59736 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Leifsonia xyli subsp. xyli] Length = 486 Score = 705 bits (1819), Expect = 0.0 Identities = 343/469 (73%), Positives = 388/469 (82%), Gaps = 4/469 (0%) Query: 16 PRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDL 75 P TLAEKVW DH+VV G+ D PDLIYIDLHLVHEVTSPQAFDGLR+AGR VRRPDL Sbjct: 7 PLTLAEKVWQDHLVVKGE----DGSPDLIYIDLHLVHEVTSPQAFDGLRVAGRPVRRPDL 62 Query: 76 TVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLG 135 T+ATEDHN PT+ IDKPIAD SR Q+ETLRRN EFGVRLH +GDIEQGIVHVVGPQLG Sbjct: 63 TIATEDHNTPTIGIDKPIADLTSRTQIETLRRNAEEFGVRLHSLGDIEQGIVHVVGPQLG 122 Query: 136 LTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPA 195 LT PG+T+VCGDSHTSTHGAFGA+A GIGTSE+EHVLATQTLPL+PFKTM +TV+G L Sbjct: 123 LTMPGITVVCGDSHTSTHGAFGAMAFGIGTSEVEHVLATQTLPLKPFKTMGITVEGELRP 182 Query: 196 GVTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPD 255 GVT GTGGGQGYVLEYRGS I ++SMEGRMT+CNMSIEAGARAGMVAPD Sbjct: 183 GVTAKDIILAVIAKIGTGGGQGYVLEYRGSAIRALSMEGRMTVCNMSIEAGARAGMVAPD 242 Query: 256 ETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQ 315 ETT+ +L+ RPHAP G+ WD AVAYW L+TDD AVFD EV+LDA + PFVTWGTNPGQ Sbjct: 243 ETTFAYLKGRPHAPEGEDWDEAVAYWTTLQTDDAAVFDAEVFLDAGEIEPFVTWGTNPGQ 302 Query: 316 GVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLR 375 GV L+ VPDP + + AR AAE+AL YMDL+ GTPM+ + VDAVF+GSCTN RIEDLR Sbjct: 303 GVSLSQDVPDPADIEEPNARAAAERALEYMDLKSGTPMKSVPVDAVFMGSCTNSRIEDLR 362 Query: 376 LVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPD 435 A V++G K A+GVR+++VPGS RVR +AEAEG+ +I GA+WR GCSMCLGMNPD Sbjct: 363 AFASVIKGRKKAEGVRVMVVPGSARVRLEAEAEGIDKIVEEFGAEWRFAGCSMCLGMNPD 422 Query: 436 QLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 QLAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGT S+P DL Sbjct: 423 QLAPGERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSPWDL 471 >tr|C0W2R0|C0W2R0_9ACTO Tax_Id=525246 (leuC)SubName: Full=3-isopropylmalate dehydratase; EC=4.2.1.33;[Actinomyces urogenitalis DSM 15434] Length = 473 Score = 704 bits (1816), Expect = 0.0 Identities = 338/468 (72%), Positives = 388/468 (82%), Gaps = 4/468 (0%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 +TLAEKVW DHVV G D PDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLT Sbjct: 3 KTLAEKVWQDHVVSQGA----DGAPDLLYIDLHLVHEVTSPQAFEGLRLAGRQVRRPDLT 58 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHN PT+DID PIAD SR Q+ETLRRNCAEFGVRLH +GD +QGIVH VGPQLGL Sbjct: 59 LATEDHNTPTLDIDLPIADLTSRTQIETLRRNCAEFGVRLHSLGDADQGIVHAVGPQLGL 118 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPGMT+VCGDSHTSTHGAFGA+A GIGTS++EHVLATQTL ++PF+TM+V +DG LPAG Sbjct: 119 TQPGMTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLQMKPFQTMSVRIDGELPAG 178 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 GT G QG+V+EYRGS IE +SME RMTICNMSIEAGARAGM+APD+ Sbjct: 179 SGAKDIILAIIAKIGTNGAQGHVIEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDQ 238 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+++L+ RPHAP G+ WDAAVA W LRTD+DAVFDTEV L+A + PFVTWGTNPGQG Sbjct: 239 TTFDYLQGRPHAPQGEDWDAAVACWSSLRTDEDAVFDTEVVLEAEDIEPFVTWGTNPGQG 298 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 +P++A+VPDPE + D+ R+AAE+AL YMDLRPGTP+R+I VD VF+GSCTNGRIEDLR Sbjct: 299 LPISATVPDPEQIADETERRAAERALEYMDLRPGTPLREIHVDTVFLGSCTNGRIEDLRA 358 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 A+V+RG A GVRML+VP S R+R QAE EGL ++F GA+WR GCSMCL MNPD+ Sbjct: 359 AAEVVRGRTKAPGVRMLVVPASARIRLQAEEEGLDQVFKDFGAEWRNAGCSMCLAMNPDK 418 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 LAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGT S PADL Sbjct: 419 LAPGERSASTSNRNFEGRQGKGGRTHLVSPVVAAATAVRGTLSTPADL 466 >tr|B4V596|B4V596_9ACTO Tax_Id=465541 SubName: Full=3-isopropylmalate dehydratase large subunit;[Streptomyces sp. Mg1] Length = 474 Score = 703 bits (1814), Expect = 0.0 Identities = 344/469 (73%), Positives = 386/469 (82%), Gaps = 5/469 (1%) Query: 17 RTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLT 76 RTLAEKVWDDHVV +G PDL++IDLHL+HEVTSPQAF+GLR AGR VRR DLT Sbjct: 3 RTLAEKVWDDHVVRRAEGE-----PDLLFIDLHLLHEVTSPQAFEGLRQAGRKVRRLDLT 57 Query: 77 VATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGL 136 +ATEDHN PT+DIDKPIADPVSR Q+ETLR NCAEFGVRLH +GD+EQG+VHVVGPQLGL Sbjct: 58 IATEDHNTPTLDIDKPIADPVSRAQLETLRANCAEFGVRLHSLGDVEQGVVHVVGPQLGL 117 Query: 137 TQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG 196 TQPG T+VCGDSHTSTHGAFGA+A GIGTS++EHVLATQTLPL KTMA+TV G L G Sbjct: 118 TQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVTGALAEG 177 Query: 197 VTXXXXXXXXXXXXGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDE 256 VT GTGGGQGY+LEYRG +E +SME RMTICNMSIEAGARAGM+APD+ Sbjct: 178 VTAKDLILAIIARIGTGGGQGYILEYRGEAVEKLSMEARMTICNMSIEAGARAGMIAPDQ 237 Query: 257 TTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQG 316 TT+++LR R HAP G+ WDAAVAYW+ LRTDDDAVFD EV +D T+LSPFVTWGTNPGQG Sbjct: 238 TTFDYLRGRDHAPEGEDWDAAVAYWRTLRTDDDAVFDAEVVIDGTALSPFVTWGTNPGQG 297 Query: 317 VPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRL 376 PL+A+VPDP D R AAEKAL YM L G P+RDI VD VFVGSCTNGRIEDLR Sbjct: 298 APLSANVPDPASYEDASERHAAEKALEYMGLEAGQPLRDINVDTVFVGSCTNGRIEDLRA 357 Query: 377 VADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQ 436 VA ++ G KVADGVRML+VPGS+RV QA EGL ++F AGA+WR GCSMCLGMNPDQ Sbjct: 358 VAGIIEGRKVADGVRMLVVPGSVRVALQAVEEGLDKVFKEAGAEWRHAGCSMCLGMNPDQ 417 Query: 437 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 LAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G ++PADL+ Sbjct: 418 LAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLS 466 Database: Amellifera_nr Posted date: Jan 15, 2010 5:10 AM Number of letters in database: 3,808,957,724 Number of sequences in database: 11,153,314 Lambda K H 0.319 0.136 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11153314 Number of Hits to DB: 3,754,673,037 Number of extensions: 162844660 Number of successful extensions: 341048 Number of sequences better than 10.0: 4680 Number of HSP's gapped: 334113 Number of HSP's successfully gapped: 5118 Length of query: 485 Length of database: 3,808,957,724 Length adjustment: 141 Effective length of query: 344 Effective length of database: 2,236,340,450 Effective search space: 769301114800 Effective search space used: 769301114800 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 82 (36.2 bits)