BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= ML2421c
         (318 letters)

Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr;
Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr;
trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr;
Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr;
Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr;
Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr;
Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr;
Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr;
Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr;
Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr;
Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr;
Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 
           11,153,314 sequences; 3,808,957,724 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits)  Value

tr|B8ZT70|B8ZT70_MYCLB Tax_Id=561304 (hemC)SubName: Full=Porphob...   530   e-149
sp|Q49808|HEM3_MYCLE Tax_Id=1769 (hemC)RecName: Full=Porphobilin...   523   e-147
sp|A0PW29|HEM3_MYCUA Tax_Id=362242 (hemC)RecName: Full=Porphobil...   451   e-125
sp|Q73SS0|HEM3_MYCPA Tax_Id=1770 (hemC)RecName: Full=Porphobilin...   451   e-125
sp|B2HRJ2|HEM3_MYCMM Tax_Id=216594 (hemC)RecName: Full=Porphobil...   450   e-125
sp|A0QLI0|HEM3_MYCA1 Tax_Id=243243 (hemC)RecName: Full=Porphobil...   450   e-124
tr|C6DT96|C6DT96_MYCTK Tax_Id=478434 SubName: Full=Porphobilinog...   448   e-124
tr|A4KEJ6|A4KEJ6_MYCTU Tax_Id=395095 SubName: Full=Porphobilinog...   448   e-124
sp|P64336|HEM3_MYCTU Tax_Id=1773 (hemC)RecName: Full=Porphobilin...   442   e-122
sp|A5TZP0|HEM3_MYCTA Tax_Id=419947 (hemC)RecName: Full=Porphobil...   442   e-122
sp|C1AKJ0|HEM3_MYCBT Tax_Id=561275 (hemC)RecName: Full=Porphobil...   442   e-122
sp|A1KFY6|HEM3_MYCBP Tax_Id=410289 (hemC)RecName: Full=Porphobil...   442   e-122
sp|P64337|HEM3_MYCBO Tax_Id=1765 (hemC)RecName: Full=Porphobilin...   442   e-122
tr|A5WJM5|A5WJM5_MYCTF Tax_Id=336982 SubName: Full=Porphobilinog...   442   e-122
tr|A2VFJ5|A2VFJ5_MYCTU Tax_Id=348776 SubName: Full=Porphobilinog...   442   e-122
tr|Q1BE86|Q1BE86_MYCSS Tax_Id=164756 SubName: Full=Hydroxymethyl...   402   e-110
tr|A1UAP8|A1UAP8_MYCSK Tax_Id=189918 SubName: Full=Hydroxymethyl...   402   e-110
sp|A1T3D3|HEM3_MYCVP Tax_Id=350058 (hemC)RecName: Full=Porphobil...   402   e-110
tr|A3PUA4|A3PUA4_MYCSJ Tax_Id=164757 SubName: Full=Hydroxymethyl...   401   e-110
tr|A0QR18|A0QR18_MYCS2 Tax_Id=246196 (hemC)SubName: Full=Porphob...   396   e-108
sp|B1MHI5|HEM3_MYCA9 Tax_Id=561007 (hemC)RecName: Full=Porphobil...   391   e-107
sp|A4T340|HEM3_MYCGI Tax_Id=350054 (hemC)RecName: Full=Porphobil...   390   e-106
tr|Q0SF27|Q0SF27_RHOSR Tax_Id=101510 SubName: Full=Hydroxymethyl...   365   4e-99
tr|C2AL32|C2AL32_TSUPA Tax_Id=521096 SubName: Full=Hydroxymethyl...   363   1e-98
tr|C1AZ43|C1AZ43_RHOOB Tax_Id=632772 (hemC)SubName: Full=Porphob...   361   7e-98
tr|C0ZUV5|C0ZUV5_RHOE4 Tax_Id=234621 (hemC)SubName: Full=Porphob...   361   7e-98
sp|Q5YP70|HEM3_NOCFA Tax_Id=37329 (hemC)RecName: Full=Porphobili...   360   2e-97
tr|C3JK04|C3JK04_RHOER Tax_Id=596309 (hemC)SubName: Full=Porphob...   360   2e-97
tr|D0L4A1|D0L4A1_9ACTO Tax_Id=526226 SubName: Full=Porphobilinog...   353   2e-95
tr|A4FPY3|A4FPY3_SACEN Tax_Id=405948 (hemC)SubName: Full=Porphob...   292   4e-77
tr|C0U8E0|C0U8E0_9ACTO Tax_Id=526225 SubName: Full=Hydroxymethyl...   291   5e-77
tr|C6WNG2|C6WNG2_ACTMD Tax_Id=446462 SubName: Full=Porphobilinog...   291   7e-77
tr|C7MT07|C7MT07_SACVD Tax_Id=471857 SubName: Full=Hydroxymethyl...   273   1e-71
tr|A4X1U2|A4X1U2_SALTO Tax_Id=369723 SubName: Full=Hydroxymethyl...   265   7e-69
tr|A3THP4|A3THP4_9MICO Tax_Id=313589 SubName: Full=Porphobilinog...   265   7e-69
tr|C4RC06|C4RC06_9ACTO Tax_Id=219305 SubName: Full=Porphobilinog...   264   9e-69
tr|A8LZJ0|A8LZJ0_SALAI Tax_Id=391037 SubName: Full=Porphobilinog...   263   3e-68
tr|C8NX90|C8NX90_9CORY Tax_Id=585529 (hemC)SubName: Full=Hydroxy...   254   9e-66
tr|C5V9U1|C5V9U1_9CORY Tax_Id=553207 (hemC)SubName: Full=Hydroxy...   249   2e-64
tr|C1WGX8|C1WGX8_9ACTO Tax_Id=479435 SubName: Full=Hydroxymethyl...   248   9e-64
tr|C0XUE8|C0XUE8_9CORY Tax_Id=525263 (hemC)SubName: Full=Porphob...   246   3e-63
sp|Q8FSF7|HEM3_COREF Tax_Id=152794 (hemC)RecName: Full=Porphobil...   243   2e-62
tr|C8NSH0|C8NSH0_COREF Tax_Id=196164 (hemC)SubName: Full=Hydroxy...   243   2e-62
sp|Q8NT90|HEM3_CORGL Tax_Id=1718 (hemC)RecName: Full=Porphobilin...   243   3e-62
sp|A4QB59|HEM3_CORGB Tax_Id=340322 (hemC)RecName: Full=Porphobil...   241   6e-62
tr|Q8GMZ1|Q8GMZ1_CORGL Tax_Id=1718 (hemC)SubName: Full=Porphobil...   241   6e-62
tr|A1SE02|A1SE02_NOCSJ Tax_Id=196162 SubName: Full=Porphobilinog...   241   8e-62
tr|C6R7U3|C6R7U3_9CORY Tax_Id=553206 (hemC)SubName: Full=Hydroxy...   239   4e-61
tr|C0WI67|C0WI67_9CORY Tax_Id=525260 (hemC)SubName: Full=Porphob...   238   7e-61
sp|C3PKG2|HEM3_CORA7 Tax_Id=548476 (hemC)RecName: Full=Porphobil...   236   2e-60

>tr|B8ZT70|B8ZT70_MYCLB Tax_Id=561304 (hemC)SubName:
           Full=Porphobilinogen deaminase;[Mycobacterium leprae]
          Length = 318

 Score =  530 bits (1365), Expect = e-149
 Identities = 284/318 (89%), Positives = 285/318 (89%)

Query: 1   LAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA 60
           +AHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA
Sbjct: 1   MAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA 60

Query: 61  LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV 120
           LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV
Sbjct: 61  LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV 120

Query: 121 GTSSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE 180
           GTSSP             EIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE
Sbjct: 121 GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE 180

Query: 181 TLDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAP 240
           TLDPVQMVPAPAQGAIAVECRAGDS                    ERVLLAELEAGCSAP
Sbjct: 181 TLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAP 240

Query: 241 VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE 300
           VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE
Sbjct: 241 VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE 300

Query: 301 LGARELMWGARSDRARGS 318
           LGARELMWGARSDRARGS
Sbjct: 301 LGARELMWGARSDRARGS 318


>sp|Q49808|HEM3_MYCLE Tax_Id=1769 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium leprae]
          Length = 315

 Score =  523 bits (1348), Expect = e-147
 Identities = 281/315 (89%), Positives = 282/315 (89%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA
Sbjct: 1   MIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS
Sbjct: 61  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQMVPAPAQGAIAVECRAGDS                    ERVLLAELEAGCSAPVGA
Sbjct: 181 PVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA
Sbjct: 241 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 300

Query: 304 RELMWGARSDRARGS 318
           RELMWGARSDRARGS
Sbjct: 301 RELMWGARSDRARGS 315


>sp|A0PW29|HEM3_MYCUA Tax_Id=362242 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium ulcerans]
          Length = 314

 Score =  451 bits (1161), Expect = e-125
 Identities = 239/306 (78%), Positives = 256/306 (83%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA+VRDALIANGH AELV ++T GD+SSA I++LGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAAIVRDALIANGHAAELVTISTLGDRSSAPIETLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           AIE+G VDAAVHS+KDLPTA DPRFT+AAIPPR DPRDAVV RD LVL ELP GSLVGTS
Sbjct: 61  AIEDGRVDAAVHSHKDLPTAQDPRFTIAAIPPRQDPRDAVVARDGLVLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLNRVS+GDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQFRALGLGLEIRPLRGNLDTRLNRVSNGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+A+ECRAGDS                    ER LLAELEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAIECRAGDSRLATVLAELDDADTRAAVTAERALLAELEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID EGRVFEELSLRGCVAALDGSDVIRASGI TSGRA ELGLAVA ELFELGA
Sbjct: 241 IAEVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGIGTSGRARELGLAVAAELFELGA 300

Query: 304 RELMWG 309
           RELMWG
Sbjct: 301 RELMWG 306


>sp|Q73SS0|HEM3_MYCPA Tax_Id=1770 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium paratuberculosis]
          Length = 315

 Score =  451 bits (1161), Expect = e-125
 Identities = 244/315 (77%), Positives = 258/315 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQA  VRDALIA GHPAELV + TAGD+SS  I+SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           AIEEG VDAAVHS+KDLPTADDPRF VAAIP RNDPRDAVV RD LVLAELP GSLVGTS
Sbjct: 61  AIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRL +VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLAELEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GR+FEELSLRGCVAALDGSDVIRASGI T GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGA 300

Query: 304 RELMWGARSDRARGS 318
           RELM GAR D ARG+
Sbjct: 301 RELMSGARHDPARGN 315


>sp|B2HRJ2|HEM3_MYCMM Tax_Id=216594 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium marinum]
          Length = 314

 Score =  450 bits (1158), Expect = e-125
 Identities = 239/306 (78%), Positives = 255/306 (83%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIANGH AELV ++T GD+SSA I++LGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIANGHAAELVTISTLGDRSSAPIETLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           AIE+G VDAAVHS+KDLPTA DPRFT+AAIPPR DPRDAVV RD LVL ELP GSLVGTS
Sbjct: 61  AIEDGRVDAAVHSHKDLPTAQDPRFTIAAIPPRQDPRDAVVARDGLVLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLNRVS+GDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSNGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+A+ECRAGDS                    ER LLAELEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAIECRAGDSRLATVLAELDDADTRAAVTAERALLAELEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID EGRVFEELSLRGCVAALDGSDVIRASGI TSGRA ELGLAVA ELFELGA
Sbjct: 241 IAEVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGIGTSGRARELGLAVAAELFELGA 300

Query: 304 RELMWG 309
           RELMWG
Sbjct: 301 RELMWG 306


>sp|A0QLI0|HEM3_MYCA1 Tax_Id=243243 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium avium]
          Length = 315

 Score =  450 bits (1157), Expect = e-124
 Identities = 243/315 (77%), Positives = 257/315 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQA  VRDALIA GHPAELV + TAGD+SS  I+SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           AIEEG VDAAVHS+KDLPTADDPRF VAAIP RNDPRDAVV RD LVL ELP GSLVGTS
Sbjct: 61  AIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRL +VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLAELEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GR+FEELSLRGCVAALDGSDVIRASGI T GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGA 300

Query: 304 RELMWGARSDRARGS 318
           RELM GAR D ARG+
Sbjct: 301 RELMSGARHDPARGN 315


>tr|C6DT96|C6DT96_MYCTK Tax_Id=478434 SubName: Full=Porphobilinogen
           deaminase hemC;[Mycobacterium tuberculosis]
          Length = 312

 Score =  448 bits (1153), Expect = e-124
 Identities = 239/311 (76%), Positives = 254/311 (81%)

Query: 1   LAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA 60
           +AHVIRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTA
Sbjct: 1   MAHVIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTA 60

Query: 61  LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV 120
           LR A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLV
Sbjct: 61  LREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLV 120

Query: 121 GTSSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE 180
           GTSSP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTE
Sbjct: 121 GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTE 180

Query: 181 TLDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAP 240
           TL+PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAP
Sbjct: 181 TLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAP 240

Query: 241 VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE 300
           VGAIA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFE
Sbjct: 241 VGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFE 300

Query: 301 LGARELMWGAR 311
           LGARELMWG R
Sbjct: 301 LGARELMWGVR 311


>tr|A4KEJ6|A4KEJ6_MYCTU Tax_Id=395095 SubName: Full=Porphobilinogen
           deaminase hemC;[Mycobacterium tuberculosis str. Haarlem]
          Length = 312

 Score =  448 bits (1153), Expect = e-124
 Identities = 239/311 (76%), Positives = 254/311 (81%)

Query: 1   LAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA 60
           +AHVIRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTA
Sbjct: 1   MAHVIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTA 60

Query: 61  LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV 120
           LR A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLV
Sbjct: 61  LREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLV 120

Query: 121 GTSSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE 180
           GTSSP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTE
Sbjct: 121 GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTE 180

Query: 181 TLDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAP 240
           TL+PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAP
Sbjct: 181 TLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAP 240

Query: 241 VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE 300
           VGAIA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFE
Sbjct: 241 VGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFE 300

Query: 301 LGARELMWGAR 311
           LGARELMWG R
Sbjct: 301 LGARELMWGVR 311


>sp|P64336|HEM3_MYCTU Tax_Id=1773 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium tuberculosis]
          Length = 309

 Score =  442 bits (1136), Expect = e-122
 Identities = 236/308 (76%), Positives = 251/308 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS
Sbjct: 61  AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300

Query: 304 RELMWGAR 311
           RELMWG R
Sbjct: 301 RELMWGVR 308


>sp|A5TZP0|HEM3_MYCTA Tax_Id=419947 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium tuberculosis]
          Length = 309

 Score =  442 bits (1136), Expect = e-122
 Identities = 236/308 (76%), Positives = 251/308 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS
Sbjct: 61  AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300

Query: 304 RELMWGAR 311
           RELMWG R
Sbjct: 301 RELMWGVR 308


>sp|C1AKJ0|HEM3_MYCBT Tax_Id=561275 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium bovis]
          Length = 309

 Score =  442 bits (1136), Expect = e-122
 Identities = 236/308 (76%), Positives = 251/308 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS
Sbjct: 61  AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300

Query: 304 RELMWGAR 311
           RELMWG R
Sbjct: 301 RELMWGVR 308


>sp|A1KFY6|HEM3_MYCBP Tax_Id=410289 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium bovis]
          Length = 309

 Score =  442 bits (1136), Expect = e-122
 Identities = 236/308 (76%), Positives = 251/308 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS
Sbjct: 61  AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300

Query: 304 RELMWGAR 311
           RELMWG R
Sbjct: 301 RELMWGVR 308


>sp|P64337|HEM3_MYCBO Tax_Id=1765 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium bovis]
          Length = 309

 Score =  442 bits (1136), Expect = e-122
 Identities = 236/308 (76%), Positives = 251/308 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS
Sbjct: 61  AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300

Query: 304 RELMWGAR 311
           RELMWG R
Sbjct: 301 RELMWGVR 308


>tr|A5WJM5|A5WJM5_MYCTF Tax_Id=336982 SubName: Full=Porphobilinogen
           deaminase hemC;[Mycobacterium tuberculosis]
          Length = 309

 Score =  442 bits (1136), Expect = e-122
 Identities = 236/308 (76%), Positives = 251/308 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS
Sbjct: 61  AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300

Query: 304 RELMWGAR 311
           RELMWG R
Sbjct: 301 RELMWGVR 308


>tr|A2VFJ5|A2VFJ5_MYCTU Tax_Id=348776 SubName: Full=Porphobilinogen
           deaminase hemC;[Mycobacterium tuberculosis C]
          Length = 309

 Score =  442 bits (1136), Expect = e-122
 Identities = 236/308 (76%), Positives = 251/308 (81%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR 
Sbjct: 1   MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS
Sbjct: 61  AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGDS                    ER LLA+LEAGCSAPVGA
Sbjct: 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA
Sbjct: 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300

Query: 304 RELMWGAR 311
           RELMWG R
Sbjct: 301 RELMWGVR 308


>tr|Q1BE86|Q1BE86_MYCSS Tax_Id=164756 SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Mycobacterium sp.]
          Length = 314

 Score =  402 bits (1034), Expect = e-110
 Identities = 213/303 (70%), Positives = 239/303 (78%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           IRIGTR SLLATTQA  +RDALIA GH AELV+++T GD++   I  +GVGVFT ALR A
Sbjct: 8   IRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVFTAALREA 67

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           I +G VDAAVHSYKDLPTA D RFT+ AIP R DPRDA+V RD LVL ELPAGS VGTSS
Sbjct: 68  IHDGRVDAAVHSYKDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSS 127

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EIRPLRGNLDTRLNRV +G+LD IVVARAGLAR+GRL +VTETL+P
Sbjct: 128 PRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGELDGIVVARAGLARIGRLGDVTETLEP 187

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVECRAGD+                    ERVLLAELEAGCSAPVGAI
Sbjct: 188 VQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGCSAPVGAI 247

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVESID +GRVFEE+SLRGCVAALDGSDVIRASGI T GRA++LG++VA ELFELGAR
Sbjct: 248 AEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGAR 307

Query: 305 ELM 307
           EL+
Sbjct: 308 ELI 310


>tr|A1UAP8|A1UAP8_MYCSK Tax_Id=189918 SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Mycobacterium sp.]
          Length = 314

 Score =  402 bits (1034), Expect = e-110
 Identities = 213/303 (70%), Positives = 239/303 (78%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           IRIGTR SLLATTQA  +RDALIA GH AELV+++T GD++   I  +GVGVFT ALR A
Sbjct: 8   IRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVFTAALREA 67

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           I +G VDAAVHSYKDLPTA D RFT+ AIP R DPRDA+V RD LVL ELPAGS VGTSS
Sbjct: 68  IHDGRVDAAVHSYKDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSS 127

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EIRPLRGNLDTRLNRV +G+LD IVVARAGLAR+GRL +VTETL+P
Sbjct: 128 PRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGELDGIVVARAGLARIGRLGDVTETLEP 187

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVECRAGD+                    ERVLLAELEAGCSAPVGAI
Sbjct: 188 VQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGCSAPVGAI 247

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVESID +GRVFEE+SLRGCVAALDGSDVIRASGI T GRA++LG++VA ELFELGAR
Sbjct: 248 AEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGAR 307

Query: 305 ELM 307
           EL+
Sbjct: 308 ELI 310


>sp|A1T3D3|HEM3_MYCVP Tax_Id=350058 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium vanbaalenii]
          Length = 312

 Score =  402 bits (1033), Expect = e-110
 Identities = 220/312 (70%), Positives = 241/312 (77%), Gaps = 1/312 (0%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQ-SSASIDSLGVGVFTTALR 62
           +IRIGTRGSLLATTQA  VRDALIA GH AELVIV+T GDQ + A I  +GVGVFT ALR
Sbjct: 1   MIRIGTRGSLLATTQAGTVRDALIAAGHDAELVIVSTEGDQRADAPIAEIGVGVFTAALR 60

Query: 63  AAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGT 122
            AI +G VDAAVHSYKDLPTA DPRF +AA P R D RDA+V RD LVL ELPAGS++GT
Sbjct: 61  EAIADGLVDAAVHSYKDLPTAPDPRFMIAATPVREDARDALVARDGLVLGELPAGSVIGT 120

Query: 123 SSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETL 182
           SSP             EIRPLRGNLDTRLNRVSSG+LDAIVVARAGLAR+GRLD VTE L
Sbjct: 121 SSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGELDAIVVARAGLARIGRLDAVTEAL 180

Query: 183 DPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVG 242
           +PVQM+PAPAQGA+AVECRAGD+                    ER LLAELEAGCSAPVG
Sbjct: 181 EPVQMLPAPAQGALAVECRAGDTALAQVLSQLDDADTRAAITAERTLLAELEAGCSAPVG 240

Query: 243 AIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELG 302
           AIA+VVESID +GRVFEELSLRGCVA LDGSDVIRA+GI T  RA ELGL+VA ELFELG
Sbjct: 241 AIAEVVESIDEDGRVFEELSLRGCVATLDGSDVIRATGIGTPDRARELGLSVAEELFELG 300

Query: 303 ARELMWGARSDR 314
           AR+L+     DR
Sbjct: 301 ARDLLDEGGRDR 312


>tr|A3PUA4|A3PUA4_MYCSJ Tax_Id=164757 SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Mycobacterium sp.]
          Length = 314

 Score =  401 bits (1030), Expect = e-110
 Identities = 212/303 (69%), Positives = 238/303 (78%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           IRIGTR SLLATTQA  +RDALI  GH AELV+++T GD++   I  +GVGVFT ALR A
Sbjct: 8   IRIGTRASLLATTQAGTIRDALIGRGHAAELVLISTEGDRNQGPIADIGVGVFTAALREA 67

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           I +G VDAAVHSYKDLPTA D RFT+ AIP R DPRDA+V RD LVL ELPAGS VGTSS
Sbjct: 68  IHDGRVDAAVHSYKDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSS 127

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EIRPLRGNLDTRLNRV +G+LD IVVARAGLAR+GRL +VTETL+P
Sbjct: 128 PRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGELDGIVVARAGLARIGRLGDVTETLEP 187

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVECRAGD+                    ERVLLAELEAGCSAPVGAI
Sbjct: 188 VQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGCSAPVGAI 247

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVESID +GRVFEE+SLRGCVAALDGSDVIRASGI T GRA++LG++VA ELFELGAR
Sbjct: 248 AEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGAR 307

Query: 305 ELM 307
           EL+
Sbjct: 308 ELI 310


>tr|A0QR18|A0QR18_MYCS2 Tax_Id=246196 (hemC)SubName:
           Full=Porphobilinogen deaminase;
           EC=2.5.1.61;[Mycobacterium smegmatis]
          Length = 318

 Score =  396 bits (1018), Expect = e-108
 Identities = 208/304 (68%), Positives = 236/304 (77%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           VIR+GTRGSLLATTQA  VRDAL+A GHP ELVI++T GD++   I  +G+GVFT ALR 
Sbjct: 8   VIRLGTRGSLLATTQAGTVRDALLAAGHPCELVIISTEGDRNQGPIADIGIGVFTAALRE 67

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           AI +G VD AVHSYKDLPTA D RF + AIP R DPRDA+V RD LVL ELP GS++GTS
Sbjct: 68  AIHDGRVDMAVHSYKDLPTASDERFCIPAIPRREDPRDALVARDGLVLGELPTGSVIGTS 127

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRLNRV+SG+LD IVVARAGLAR+GRL+ VTETL+
Sbjct: 128 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVTSGELDGIVVARAGLARIGRLNVVTETLE 187

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQM+PAPAQGA+AVECRAGD+                    ERVLLAELEAGCSAPVGA
Sbjct: 188 PVQMLPAPAQGALAVECRAGDTELIAILSELDDADTRAAVTAERVLLAELEAGCSAPVGA 247

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID +G VFEELSLRGC A LDGSDVIRASGI T  RA+ELG++VA ELF+LGA
Sbjct: 248 IAEVVESIDEDGNVFEELSLRGCAATLDGSDVIRASGIGTPDRAAELGVSVAAELFDLGA 307

Query: 304 RELM 307
           REL+
Sbjct: 308 RELL 311


>sp|B1MHI5|HEM3_MYCA9 Tax_Id=561007 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium abscessus]
          Length = 306

 Score =  391 bits (1005), Expect = e-107
 Identities = 208/304 (68%), Positives = 236/304 (77%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +IRIGTRGSLLATTQA  +RDAL A GH AELVIV TAGDQS+A ++ +GVGVFT ALR 
Sbjct: 1   MIRIGTRGSLLATTQAGGIRDALRAKGHEAELVIVTTAGDQSAAPVEQIGVGVFTAALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           AI +  VD AVHSYKDLPTA DPRF + AIPPR D RDA+V RD LVL ELPAGS++GTS
Sbjct: 61  AIADDVVDVAVHSYKDLPTAADPRFVIPAIPPREDYRDALVARDGLVLGELPAGSVIGTS 120

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           SP             EIRPLRGNLDTRL+RVS+GDLD +VVARAGLAR+GRLD +TETL+
Sbjct: 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLSRVSNGDLDGVVVARAGLARIGRLDHITETLE 180

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           PVQ++PAPAQGA+AVECR+  +                    ER LLAELEAGC+APVGA
Sbjct: 181 PVQVLPAPAQGALAVECRSEATDLVAVLAELDHADTRAAVTAERALLAELEAGCTAPVGA 240

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
           IA+VVESID EGRVF+ELSLRGC AALDGSDVIRASGI T  RA+ELGLAVA EL +LGA
Sbjct: 241 IAEVVESIDEEGRVFDELSLRGCAAALDGSDVIRASGIGTPDRAAELGLAVARELLDLGA 300

Query: 304 RELM 307
           R L+
Sbjct: 301 RALI 304


>sp|A4T340|HEM3_MYCGI Tax_Id=350054 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Mycobacterium gilvum]
          Length = 312

 Score =  390 bits (1001), Expect = e-106
 Identities = 208/305 (68%), Positives = 238/305 (78%), Gaps = 1/305 (0%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQ-SSASIDSLGVGVFTTALR 62
           +IRIGTRGSLLATTQA  +RDALIA GH AELVI++T GD+ +   I  +GVGVFT ALR
Sbjct: 1   MIRIGTRGSLLATTQAGTIRDALIAAGHDAELVIISTEGDRRADEPIADIGVGVFTAALR 60

Query: 63  AAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGT 122
            AI +  VDAAVHSYKDLPTA DPRF +AA P R D RDA+V RD +VL ELPAGS++GT
Sbjct: 61  EAIADNVVDAAVHSYKDLPTAVDPRFMIAATPVREDARDALVARDGMVLGELPAGSVIGT 120

Query: 123 SSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETL 182
           SSP             EIRPLRGNLDTRLNRVSSG+LDAIVVA+AGL+R+GRL+ VTETL
Sbjct: 121 SSPRRVAQLKALGLGLEIRPLRGNLDTRLNRVSSGELDAIVVAKAGLSRIGRLEVVTETL 180

Query: 183 DPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVG 242
           +PVQM+PAPAQGA+A+ECRAGD+                    ER LLAELEAGCSAPVG
Sbjct: 181 EPVQMLPAPAQGALAIECRAGDTALAQLLAELDDADTRAAVTAERTLLAELEAGCSAPVG 240

Query: 243 AIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELG 302
           AIA+VVESID +GRVFEELSLRGCVA LDGSDVIRASGI +  RA ELGL+VA ELF+LG
Sbjct: 241 AIAEVVESIDEDGRVFEELSLRGCVATLDGSDVIRASGIGSPDRARELGLSVAAELFDLG 300

Query: 303 ARELM 307
           AR+L+
Sbjct: 301 ARDLL 305


>tr|Q0SF27|Q0SF27_RHOSR Tax_Id=101510 SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Rhodococcus sp.]
          Length = 321

 Score =  365 bits (937), Expect = 4e-99
 Identities = 189/303 (62%), Positives = 226/303 (74%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGS LATTQA  VRDALI+ GH AELVI+ T GDQS  S++ +GVGVFT  LR A
Sbjct: 9   LRIGTRGSELATTQAGTVRDALISAGHDAELVIIKTKGDQSMESVEKIGVGVFTAELREA 68

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           + +G VD AVHSYKDLPTA D RFT+AAIPPR DPRDA+V RD LVL ELPAGS VGTS+
Sbjct: 69  LADGRVDVAVHSYKDLPTAPDERFTIAAIPPREDPRDALVARDGLVLGELPAGSKVGTSA 128

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             +IRPLRGNL  RL +V SG+LDA+V+ARAGLAR+GRLD +TE+++P
Sbjct: 129 PRRTSQLRALGLGLDIRPLRGNLQRRLGKVESGELDAVVLARAGLARIGRLDLITESIEP 188

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVEC + ++                    ER LLAELEAGC+APVGAI
Sbjct: 189 VQMLPAPAQGALAVECLSANTALVAILSELDDPNSRAAVTAERALLAELEAGCTAPVGAI 248

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVES+D +GR+F+ELS+RGC AA+DGSDVIR   + +   A ELG +VA EL ELGAR
Sbjct: 249 AEVVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGSPENAEELGRSVARELLELGAR 308

Query: 305 ELM 307
           ELM
Sbjct: 309 ELM 311


>tr|C2AL32|C2AL32_TSUPA Tax_Id=521096 SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Tsukamurella paurometabola DSM 20162]
          Length = 318

 Score =  363 bits (932), Expect = 1e-98
 Identities = 192/303 (63%), Positives = 223/303 (73%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGSLLATTQA  VRDALIA GHPAELVIV T GD SS  ++ +GVGVFT+ALR A
Sbjct: 15  LRIGTRGSLLATTQAGTVRDALIAAGHPAELVIVTTPGDLSSDPVEKIGVGVFTSALRDA 74

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +  G VD AVHSYKDLPTA D R  +AA+PPR D RDA+V RD +VL ELPAGS+VGTSS
Sbjct: 75  LANGEVDVAVHSYKDLPTAPDDRLVLAAVPPREDSRDALVARDGMVLGELPAGSVVGTSS 134

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EIRPLRGNLD+RL +V+ G+LDAIVVA AGL R+GR DEVTE LDP
Sbjct: 135 PRRATQLTALGLGLEIRPLRGNLDSRLRKVADGELDAIVVALAGLKRIGRHDEVTEALDP 194

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVECR GD+                    ER LLAELEAGC+APVGAI
Sbjct: 195 VQMLPAPAQGALAVECRRGDADLQSVLSELDDHWTRAAVTAERALLAELEAGCTAPVGAI 254

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVES+D +GR+FEELSLRG   A DGSD ++AS +   G A  LG A+A EL +LGAR
Sbjct: 255 AEVVESLDDDGRIFEELSLRGIALAADGSDSVKASAVGPVGEAGALGTALARELLDLGAR 314

Query: 305 ELM 307
           +L+
Sbjct: 315 DLL 317


>tr|C1AZ43|C1AZ43_RHOOB Tax_Id=632772 (hemC)SubName:
           Full=Porphobilinogen deaminase; EC=2.5.1.61;[Rhodococcus
           opacus]
          Length = 321

 Score =  361 bits (926), Expect = 7e-98
 Identities = 188/303 (62%), Positives = 224/303 (73%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGS LATTQA  VRDALI+ GH AELVI+ T GDQS  S++ +GVGVFT  LR A
Sbjct: 9   LRIGTRGSELATTQAGTVRDALISAGHDAELVIIKTKGDQSMESVEKIGVGVFTAELREA 68

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           + +G VD AVHSYKDLPTA D RFT+AAIPPR DPRDA+V RD LVL ELP GS VGTS+
Sbjct: 69  LADGRVDVAVHSYKDLPTARDERFTIAAIPPREDPRDALVARDGLVLGELPPGSKVGTSA 128

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             +I PLRGNL  RL +V SG+LDA+V+ARAGLAR+GRLD +TE+L+P
Sbjct: 129 PRRTSQLRALGLGLDILPLRGNLQRRLGKVESGELDAVVLARAGLARIGRLDLITESLEP 188

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVEC + ++                    ER LLAELEAGC+APVGAI
Sbjct: 189 VQMLPAPAQGALAVECLSANTALVAILSELDDPNSRAAVTAERALLAELEAGCTAPVGAI 248

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVES+D +GR+F+ELS+RGC AA+DGSDVIR   + +   A ELG +VA EL ELGAR
Sbjct: 249 AEVVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGSPENAEELGRSVARELLELGAR 308

Query: 305 ELM 307
           ELM
Sbjct: 309 ELM 311


>tr|C0ZUV5|C0ZUV5_RHOE4 Tax_Id=234621 (hemC)SubName:
           Full=Porphobilinogen deaminase; EC=2.5.1.61;[Rhodococcus
           erythropolis]
          Length = 324

 Score =  361 bits (926), Expect = 7e-98
 Identities = 186/303 (61%), Positives = 222/303 (73%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGSLLATTQA  VRDALIA GHPAELVI+ T GDQS+  +  +GVGVFT  LR A
Sbjct: 12  LRIGTRGSLLATTQAGTVRDALIAAGHPAELVIIKTKGDQSTDPVQKIGVGVFTAELREA 71

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           + +  VD AVHSYKDLPTA DPRF +AAIPPR DPRDA+V RD LVL ELPAGS VGTS+
Sbjct: 72  LLDNRVDVAVHSYKDLPTAQDPRFVIAAIPPREDPRDALVARDGLVLGELPAGSKVGTSA 131

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             +I PLRGNL  RL +V SG+LDA+++ARAGL+R+G LD +TE ++P
Sbjct: 132 PRRVSQLKALGLGLDIVPLRGNLQRRLGKVESGELDAVILARAGLSRIGLLDLITENIEP 191

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVEC + +                     ER LLAELEAGC+APVGAI
Sbjct: 192 VQMLPAPAQGALAVECLSANVELAAILAEHDDAGTRAAVTAERALLAELEAGCTAPVGAI 251

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A++VES+D +GR+F+ELS+RGC AA+DGSDVIR   +    +A ELG AVA EL ELGAR
Sbjct: 252 AEIVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGAPDKAEELGRAVARELLELGAR 311

Query: 305 ELM 307
           ELM
Sbjct: 312 ELM 314


>sp|Q5YP70|HEM3_NOCFA Tax_Id=37329 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen synthase;[Nocardia
           farcinica]
          Length = 346

 Score =  360 bits (923), Expect = 2e-97
 Identities = 188/303 (62%), Positives = 225/303 (74%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGSLLA TQA  VRDALIA G PAELV+V T GD SS  +  +GVGVFT+ALR  
Sbjct: 10  LRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVGVFTSALRDE 69

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +  G +D AVHSYKDLPTA DPRF +AAIPPR DPRDA+V RD LVL ELPAG+ VGTS+
Sbjct: 70  LAAGTIDLAVHSYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELPAGAKVGTSA 129

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             +I PLRGNLD+RL RV+ G+LDA+VVARAGL+R+GR   +TE L+P
Sbjct: 130 PRRVAQLRALGLGLDIVPLRGNLDSRLARVTDGELDAVVVARAGLSRIGRTAVITEALEP 189

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVECR+ D+                    ER LLAELEAGC+APVGA+
Sbjct: 190 VQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEAGCTAPVGAL 249

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVES+D +GR+ EELSLRGC AA+DGS+V+RAS +    RA+ELG A+A EL ELGAR
Sbjct: 250 AEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALARELLELGAR 309

Query: 305 ELM 307
           EL+
Sbjct: 310 ELL 312


>tr|C3JK04|C3JK04_RHOER Tax_Id=596309 (hemC)SubName:
           Full=Porphobilinogen deaminase; EC=2.5.1.61;[Rhodococcus
           erythropolis SK121]
          Length = 324

 Score =  360 bits (923), Expect = 2e-97
 Identities = 185/303 (61%), Positives = 222/303 (73%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGSLLATTQA  VRDALIA GHPAELVI+ T GDQS+  +  +GVGVFT  LR A
Sbjct: 12  LRIGTRGSLLATTQAGTVRDALIAAGHPAELVIIKTKGDQSTDPVQKIGVGVFTAELREA 71

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           + +  VD AVHSYKDLPTA DPRF +AAIPPR DPRDA+V RD LVL ELPAGS VGTS+
Sbjct: 72  LVDNRVDVAVHSYKDLPTAQDPRFVIAAIPPREDPRDALVARDGLVLGELPAGSKVGTSA 131

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             +I PLRGNL  RL +V SG+LDA+++ARAGL+R+G LD +TE ++P
Sbjct: 132 PRRVSQLKALGLGLDIVPLRGNLQRRLGKVESGELDAVILARAGLSRIGLLDLITENIEP 191

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           VQM+PAPAQGA+AVEC + ++                    ER LLA LEAGC+APVGAI
Sbjct: 192 VQMLPAPAQGALAVECLSANAELAAILAEHDDAGTRAAVTAERALLAGLEAGCTAPVGAI 251

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A++VES+D +GR+F+ELS+RGC AA+DGSDVIR   +    +A ELG AVA EL ELGAR
Sbjct: 252 AEIVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGAPDKAEELGRAVARELLELGAR 311

Query: 305 ELM 307
           ELM
Sbjct: 312 ELM 314


>tr|D0L4A1|D0L4A1_9ACTO Tax_Id=526226 SubName: Full=Porphobilinogen
           deaminase; EC=2.5.1.61;[Gordonia bronchialis DSM 43247]
          Length = 313

 Score =  353 bits (905), Expect = 2e-95
 Identities = 183/303 (60%), Positives = 222/303 (73%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           IRIGTRGSLLATTQA  + DAL   GHPAELVI+ TAGD S+A +  +GVGVFTTA+R A
Sbjct: 9   IRIGTRGSLLATTQAQTIADALTEAGHPAELVIIRTAGDDSAAPVAEIGVGVFTTAIRIA 68

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +    VD AVHSYKDLPTAD+P   +AA+PPR DPRDA+V+RD +VL ELP GS +GTS+
Sbjct: 69  LHNREVDVAVHSYKDLPTADEPGLYIAAVPPREDPRDALVSRDNMVLGELPPGSTIGTSA 128

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EIRPLRGNLD+RL +V+SG+LDA+VVARAGL R+GR DEVTE+ DP
Sbjct: 129 PRRVAQLRALGLGLEIRPLRGNLDSRLGKVASGELDAVVVARAGLVRIGRADEVTESFDP 188

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
           V ++PAPAQGA+AVECR+ D+                    ER +LA LEAGC+AP+GAI
Sbjct: 189 VVLLPAPAQGALAVECRSDDAQLVRILAELDDESTRAAIDAERAVLAALEAGCTAPIGAI 248

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A+VVESID +GR+F ELSLR  VAA DGSDVIRAS +    RA++LG  +A EL ELGA 
Sbjct: 249 AEVVESIDDDGRIFAELSLRAAVAAEDGSDVIRASVVGPVDRAAQLGADLAAELLELGAG 308

Query: 305 ELM 307
           +L+
Sbjct: 309 DLV 311


>tr|A4FPY3|A4FPY3_SACEN Tax_Id=405948 (hemC)SubName:
           Full=Porphobilinogen deaminase;
           EC=2.5.1.61;[Saccharopolyspora erythraea]
          Length = 315

 Score =  292 bits (747), Expect = 4e-77
 Identities = 160/303 (52%), Positives = 203/303 (66%), Gaps = 4/303 (1%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGS LA  Q + V +AL   G+  ELV V+T GD+S A I  +GVGVFT+ALR A
Sbjct: 5   LRIGTRGSALAMAQTSWVAEALEKAGYRTELVTVSTPGDRSMAPIAEIGVGVFTSALRDA 64

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           + +G VD AVHSYKDLPTA DPR ++AA+P R DPRDA+V RD L L ELP GS+VGT S
Sbjct: 65  LADGEVDVAVHSYKDLPTAPDPRLSLAAVPVREDPRDALVARDGLTLGELPPGSVVGTGS 124

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             E+R +RGN+DTR+ +V+ G+LDA+V+ARAGLAR+GRL  +TETLDP
Sbjct: 125 PRRAGQLKALGLGLEVRDIRGNVDTRMRKVTDGELDAVVLARAGLARVGRLAGITETLDP 184

Query: 185 VQMVPAPAQGAIAVECRAGD-SXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           +QM+PAPAQGA+AVECR  D                      ER +LA LEAGCSAPVGA
Sbjct: 185 LQMLPAPAQGALAVECRVDDVDTEHLLQSVLDDQASRVAVAAERAMLAALEAGCSAPVGA 244

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGS---DVIRASGISTSGRASELGLAVAVELFE 300
           +A+VVE +D +GRV + L +RG VA  D S   D++RAS    +  A +LG  +A +L +
Sbjct: 245 LAEVVEDLDADGRVAQRLFVRGVVAVDDASGRVDLLRASVTGETTAAEQLGRELAAQLLD 304

Query: 301 LGA 303
             A
Sbjct: 305 ARA 307


>tr|C0U8E0|C0U8E0_9ACTO Tax_Id=526225 SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Geodermatophilus obscurus DSM 43160]
          Length = 312

 Score =  291 bits (746), Expect = 5e-77
 Identities = 165/309 (53%), Positives = 198/309 (64%), Gaps = 7/309 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIA-NGHPAELVIVNTAGDQSSASIDSLG-VGVFTTALR 62
           +R+GTR S LATTQ+  V DA+ A +G P ELV ++T GD+SS +I  LG  GVF TA+R
Sbjct: 9   LRLGTRASQLATTQSQAVADAITAASGVPVELVHISTEGDRSSVAIAQLGGTGVFVTAIR 68

Query: 63  AAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGT 122
            A+ EG VD AVHSYKDLPT  +P  T+AA+PPR DPRDA+V RD L L ELPAG+ VGT
Sbjct: 69  QALLEGTVDVAVHSYKDLPTLPEPGLTIAAVPPREDPRDALVARDGLTLGELPAGARVGT 128

Query: 123 SSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETL 182
            +P             E+ P+RGN+DTR+ RV  GDLDA+V+ARAGL+RLGRL  VTETL
Sbjct: 129 GAPRRVAQLRALGLGLEVVPIRGNVDTRMARVVPGDLDAVVLARAGLSRLGRLSAVTETL 188

Query: 183 DPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVG 242
           DP+Q++PAPAQGA+AVECR  D                     ER  LA LEAGCSAPV 
Sbjct: 189 DPLQVLPAPAQGALAVECRGNDERTRQLLAALDDAATRACVVAERTTLAALEAGCSAPVA 248

Query: 243 AIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELG 302
           A A+V E  DG      EL LR  V ALDGSD +R S       A  LG  +A EL + G
Sbjct: 249 AYAEVAEGEDG-----PELFLRASVTALDGSDGVRGSITGPPPEAERLGRELAAELLDRG 303

Query: 303 ARELMWGAR 311
           A ELM  +R
Sbjct: 304 AAELMAASR 312


>tr|C6WNG2|C6WNG2_ACTMD Tax_Id=446462 SubName: Full=Porphobilinogen
           deaminase; EC=2.5.1.61; Flags: Precursor;[Actinosynnema
           mirum]
          Length = 313

 Score =  291 bits (745), Expect = 7e-77
 Identities = 160/298 (53%), Positives = 196/298 (65%), Gaps = 2/298 (0%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGS LA  Q   V +AL A G   E+V V+T GD+S A I  +G+GVFT+ALR A
Sbjct: 5   LRIGTRGSALALAQTGTVAEALRAAGAQVEIVTVSTPGDRSHAPIAEIGIGVFTSALRDA 64

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +  G VD AVHSYKDLPTA D R ++AAIP R DPRDA+V RD L L ELP GS VGT S
Sbjct: 65  LAHGEVDVAVHSYKDLPTAPDTRLSLAAIPQREDPRDALVARDGLTLGELPPGSKVGTGS 124

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EI P+RGN+D+R+ RV  G+LDA+V+ARAG++RLGR++ +TE LDP
Sbjct: 125 PRRATQLAALGLGLEILPIRGNIDSRMARVFDGELDAVVLARAGISRLGRVENITEVLDP 184

Query: 185 VQMVPAPAQGAIAVECRAGD-SXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           +QM+PAPAQGA+A+ECR  D                      ER +LA LEAGCSAPVGA
Sbjct: 185 IQMLPAPAQGALAIECRVDDVDTEHLLRSTLDDSASRAAVTAERAMLAALEAGCSAPVGA 244

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFEL 301
           +A VVE +D EG     +SLRG VAA DG D++RAS       A ELG A+A EL +L
Sbjct: 245 LADVVEDLDDEGAAVLRISLRGVVAAEDG-DLLRASATGDLTAAEELGRALAAELLDL 301


>tr|C7MT07|C7MT07_SACVD Tax_Id=471857 SubName:
           Full=Hydroxymethylbilane synthase;[Saccharomonospora
           viridis]
          Length = 316

 Score =  273 bits (699), Expect = 1e-71
 Identities = 153/309 (49%), Positives = 194/309 (62%), Gaps = 4/309 (1%)

Query: 2   AHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTAL 61
           +  +RIGTR S LA +Q   +   L   G   ELV V+T GD+SSA I  +GVGVFT+AL
Sbjct: 6   SRTLRIGTRASNLAMSQTRTIAKMLEEAGQKVELVPVSTPGDRSSAPIAEIGVGVFTSAL 65

Query: 62  RAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVG 121
           R A+    VD AVHSYKDLPTA  P   +AA+  R DPRD +++RD L L ELP G+ VG
Sbjct: 66  REALLANEVDVAVHSYKDLPTAPQPGIVLAAVSKREDPRDVLISRDGLTLGELPPGAKVG 125

Query: 122 TSSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTET 181
           T SP             EI P+RGN+DTR+ +V+SG+LDAIV+A+AGL R+G+LD +TE 
Sbjct: 126 TGSPRRMTQLRALGLGLEIVPIRGNIDTRIAKVTSGELDAIVLAKAGLTRVGKLDLITEV 185

Query: 182 LDPVQMVPAPAQGAIAVECRAGD-SXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAP 240
           +DP+Q++PAPAQGA+AVE R  D                      ER +LA L+AGCSAP
Sbjct: 186 IDPMQILPAPAQGALAVETRVDDVDTEHLLRSIVDHEATRVAVAAERAVLATLQAGCSAP 245

Query: 241 VGAIAQVVESIDGEGRVFEELSLRGCVAAL---DGSDVIRASGISTSGRASELGLAVAVE 297
           VGA+A+VVE +D EG V E LSLRG  A     D   ++RASG++    A  LG  VA E
Sbjct: 246 VGALAEVVEDLDSEGAVVERLSLRGVAATATEGDSVQILRASGVADKHEADRLGRTVASE 305

Query: 298 LFELGAREL 306
           L +LGA  L
Sbjct: 306 LLDLGAGAL 314


>tr|A4X1U2|A4X1U2_SALTO Tax_Id=369723 SubName:
           Full=Hydroxymethylbilane synthase; EC=2.5.1.61; Flags:
           Precursor;[Salinispora tropica]
          Length = 322

 Score =  265 bits (676), Expect = 7e-69
 Identities = 155/311 (49%), Positives = 193/311 (62%), Gaps = 8/311 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIA-NGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +R+GTRGS LA  Q+  V +AL A  G P ELV V T GD+S+A +  LGVGVF +ALR 
Sbjct: 5   LRLGTRGSALAMAQSGQVAEALTAATGTPVELVEVVTTGDRSTAPVHQLGVGVFVSALRD 64

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+  G +D AVHSYKDLPTA  P   VAA+PPR DPRDA+V      LAELP G+ VGT 
Sbjct: 65  ALAAGAIDFAVHSYKDLPTAAAPGLYVAAVPPRQDPRDALVATGGRTLAELPPGARVGTG 124

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRV--SSGDLDAIVVARAGLARLGRLDEVTET 181
           +              E++P+RGN+ TRL RV     DLDA+V+ARAGLARL R D +TET
Sbjct: 125 ALRRIAQLHALGLQLEVQPIRGNVGTRLARVLGPEADLDAVVLARAGLARLDRTDTITET 184

Query: 182 LDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPV 241
           LDP+ M+PAPAQGA+AVECR+ DS                    ER LLA LEAGCSAPV
Sbjct: 185 LDPMLMLPAPAQGALAVECRSDDSALVELLAVLDHAPSRATVVAERALLATLEAGCSAPV 244

Query: 242 GAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFEL 301
            A A++      EG V EE+ LRG V + DG+  +R S   T   A E+G A+A +L +L
Sbjct: 245 AAYAEL-----AEGDVGEEIYLRGAVISPDGTRDLRLSRTGTPADAVEIGKALATDLLDL 299

Query: 302 GARELMWGARS 312
           GA  ++   R+
Sbjct: 300 GADSILGQQRN 310


>tr|A3THP4|A3THP4_9MICO Tax_Id=313589 SubName: Full=Porphobilinogen
           deaminase; EC=2.5.1.61;[Janibacter sp. HTCC2649]
          Length = 329

 Score =  265 bits (676), Expect = 7e-69
 Identities = 154/304 (50%), Positives = 189/304 (62%), Gaps = 7/304 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSL--GVGVFTTALR 62
           +R+GTR S LATTQ+  V D L A GH  ELV + T GD+   +  +   G GVF +ALR
Sbjct: 3   LRLGTRRSALATTQSGWVADQLRALGHDVELVEITTDGDRDRTTPLATMGGTGVFVSALR 62

Query: 63  AAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGT 122
            A+  G VD AVHS KDLPT  +    VAAIPPR DPRDA+V RD L L ELP+GS VGT
Sbjct: 63  DALRAGTVDLAVHSLKDLPTTPEDDLAVAAIPPREDPRDALVARDGLTLGELPSGSTVGT 122

Query: 123 SSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETL 182
            SP             +IR LRGN+DTRL RV+SGDLDA+V+A+AGLARLGR   VTE +
Sbjct: 123 GSPRRRAQLEALGLGLDIRELRGNVDTRLGRVTSGDLDAVVLAQAGLARLGRTSVVTEVI 182

Query: 183 DPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVG 242
           DP+QM+PAP QGA+AVE RA D+                    ER +L+ELE GCSAPVG
Sbjct: 183 DPIQMLPAPGQGALAVEVRADDAATRDAVAALDDADTRACVDAERAVLSELEVGCSAPVG 242

Query: 243 AIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELG 302
           A+A++V   DG     +ELSLR  VA+ DG+  IR S   +   A  +G  +A  L E G
Sbjct: 243 ALAEIVLGDDG-----DELSLRAVVASPDGTGDIRRSATGSPTDADGIGRRLARLLLEDG 297

Query: 303 AREL 306
           A +L
Sbjct: 298 AADL 301


>tr|C4RC06|C4RC06_9ACTO Tax_Id=219305 SubName: Full=Porphobilinogen
           deaminase;[Micromonospora sp. ATCC 39149]
          Length = 322

 Score =  264 bits (675), Expect = 9e-69
 Identities = 155/306 (50%), Positives = 191/306 (62%), Gaps = 8/306 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIA-NGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +R+GTRGS LA  Q+  V  AL A  G   ELV V TAGD+SSA +  LGVGVF +ALR 
Sbjct: 5   LRLGTRGSALAIAQSGQVAAALTAATGREVELVEVVTAGDRSSAPVHRLGVGVFVSALRD 64

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+    +D AVHSYKDLPTA      +AA+PPR DPRDA+V +    LAELP G++VGT 
Sbjct: 65  ALVARTIDLAVHSYKDLPTAAASGLHIAAVPPRQDPRDALVAKGGRTLAELPPGAVVGTG 124

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRV--SSGDLDAIVVARAGLARLGRLDEVTET 181
           +              E+ P+RGN+DTRL RV     DLDA+V+ARAGLARLGR D +TET
Sbjct: 125 ALRRIAQLHALGLQLEVTPIRGNVDTRLARVLGPDADLDAVVLARAGLARLGRTDVITET 184

Query: 182 LDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPV 241
           LDP+ M+PAPAQGA+AVECRA D                     ER LLA LEAGCSAPV
Sbjct: 185 LDPMLMLPAPAQGALAVECRADDPDLVELLAVLDHAPSRAAVTAERALLATLEAGCSAPV 244

Query: 242 GAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFEL 301
            A A++      EG V +E+ LRG V + DG+  +R S   T   A+E+G A+A EL EL
Sbjct: 245 AAYAEL-----AEGDVGDEIYLRGAVISSDGTRDLRLSRTGTPADAAEIGKALAAELLEL 299

Query: 302 GARELM 307
           GA  ++
Sbjct: 300 GADSIL 305


>tr|A8LZJ0|A8LZJ0_SALAI Tax_Id=391037 SubName: Full=Porphobilinogen
           deaminase; EC=2.5.1.61;[Salinispora arenicola]
          Length = 322

 Score =  263 bits (671), Expect = 3e-68
 Identities = 154/306 (50%), Positives = 192/306 (62%), Gaps = 8/306 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIA-NGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +R+GTRGS LA  Q+  V  AL A  G+P ELV V TAGD+S+A +  LGVGVF +ALR 
Sbjct: 5   LRLGTRGSALAMAQSGQVAQALTAATGNPVELVEVVTAGDRSAAPVHRLGVGVFVSALRD 64

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+    +D AVHS+KDLPTA  P   VAA+PPR DPRDA+V R    LAELP G+ VGT 
Sbjct: 65  ALTARTIDFAVHSFKDLPTAAAPGLHVAAVPPRQDPRDALVARAGRTLAELPPGARVGTG 124

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRV--SSGDLDAIVVARAGLARLGRLDEVTET 181
           +              +++P+RGN+ TRL RV     DLDA+V+ARAGLARL R D +TET
Sbjct: 125 ALRRIAQLHALGLQLDVQPIRGNVGTRLARVLGPEADLDAVVLARAGLARLDRTDTITET 184

Query: 182 LDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPV 241
           LDP+ M+PAPAQGA+AVECR+ DS                    ER LLA LEAGCSAPV
Sbjct: 185 LDPMLMLPAPAQGALAVECRSDDSDLVELLAVLDHAPSRATVVAERALLATLEAGCSAPV 244

Query: 242 GAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFEL 301
            A A++      EG V EE+ LRG V + DG+  +R S   T   A E+G A+A +L EL
Sbjct: 245 AAYAEL-----AEGDVGEEIYLRGAVISPDGTRDLRLSRTGTPADAVEIGKALAADLLEL 299

Query: 302 GARELM 307
           GA  ++
Sbjct: 300 GADSIL 305


>tr|C8NX90|C8NX90_9CORY Tax_Id=585529 (hemC)SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Corynebacterium genitalium ATCC 33030]
          Length = 295

 Score =  254 bits (649), Expect = 9e-66
 Identities = 145/307 (47%), Positives = 194/307 (63%), Gaps = 12/307 (3%)

Query: 1   LAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA 60
           +   +R+ TRGS LATTQA  +RDALI+ GH AEL IV TAGD S A ++ +GVGVFTTA
Sbjct: 1   MTETLRVATRGSKLATTQAGHIRDALISAGHSAELTIVTTAGDMSQAPVERIGVGVFTTA 60

Query: 61  LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV 120
           +R A+ +G  D AVHS+KDLPTA +PR T   IP R D R+A++ RD L LA+LP+G+ V
Sbjct: 61  IRQALFDGEADVAVHSFKDLPTAHEPR-THLIIPVREDRREALIARDGLKLADLPSGARV 119

Query: 121 GTSSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE 180
           GTS+P             +I PLRGN+++R+ RV+SG+LDA+V+A AG++R+G  +  TE
Sbjct: 120 GTSAPRRIAQLRAKRPDLDIHPLRGNIESRMGRVTSGELDAVVLAYAGMSRVGLGERATE 179

Query: 181 TLDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAP 240
              P   +PAPAQGA+AVECRA D+                    ER +LA LEAGC+AP
Sbjct: 180 VFAPEDFMPAPAQGALAVECRAEDAQAVAAIDTLVDDFATRCALTERFVLATLEAGCTAP 239

Query: 241 VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE 300
           V A A     +DG     +E+++RG V ALDGS  +      T  R  E+G A A +LF+
Sbjct: 240 VAASA----VLDG-----DEITVRGGVFALDGSAQLVREASGTDPR--EVGQACAQQLFD 288

Query: 301 LGARELM 307
            GA + +
Sbjct: 289 AGAAQFL 295


>tr|C5V9U1|C5V9U1_9CORY Tax_Id=553207 (hemC)SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Corynebacterium matruchotii ATCC 14266]
          Length = 298

 Score =  249 bits (637), Expect = 2e-64
 Identities = 141/301 (46%), Positives = 184/301 (61%), Gaps = 9/301 (2%)

Query: 7   IGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAAIE 66
           IGTRGSLLATTQA  VRDAL ++G+P+EL IV T GD + A ++ +GVGVFT ALR ++ 
Sbjct: 4   IGTRGSLLATTQAGHVRDALTSHGYPSELRIVTTTGDVNLAPVERIGVGVFTQALRDSLL 63

Query: 67  EGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSSPX 126
            G  D AVHS+KDLPTA D RF +  +P R + RD ++ R+ L LAELP G++VGT +P 
Sbjct: 64  AGECDIAVHSFKDLPTAVDERFHL-VVPHRENARDCLIARNNLTLAELPTGAVVGTGAPR 122

Query: 127 XXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDPVQ 186
                          PLRGN+DTR+ +V  G+LDA+V+A AGL+R+ R DE TE  DP++
Sbjct: 123 RIAQLKALRPDIHTVPLRGNIDTRMAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLE 182

Query: 187 MVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAIAQ 246
            +PAPAQGA+AVECRA D+                    ERV+LA LEAGC+APV A A 
Sbjct: 183 FLPAPAQGALAVECRADDADTIAAITTIADPKAYACAHTERVVLARLEAGCTAPVAAYAT 242

Query: 247 VVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAREL 306
           V             ++L   V A+DGS  +RA+       A  LG+ VA  L + GA  L
Sbjct: 243 VAAD--------NIMTLHAAVIAVDGSATLRATAAGPIDTAENLGMTVARALLDDGASSL 294

Query: 307 M 307
           +
Sbjct: 295 L 295


>tr|C1WGX8|C1WGX8_9ACTO Tax_Id=479435 SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Kribbella flavida DSM 17836]
          Length = 294

 Score =  248 bits (632), Expect = 9e-64
 Identities = 145/298 (48%), Positives = 184/298 (61%), Gaps = 7/298 (2%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLG-VGVFTTALR 62
           +I++GTR S LAT QAALV DAL   GH  +LV + T GD + A ++ +G  GVF +ALR
Sbjct: 1   MIKLGTRRSALATAQAALVADALRNLGHEVDLVPIVTTGDVNRAPLEQIGGTGVFVSALR 60

Query: 63  AAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGT 122
            A+  G +D AVHS KDLPTA     T+ AIP R DPRD +V RD L L EL  G+LVGT
Sbjct: 61  DALLAGEIDIAVHSLKDLPTAPVDGLTLGAIPVREDPRDVLVARDGLTLGELQTGALVGT 120

Query: 123 SSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETL 182
            SP             E+  +RGN+DTR+  V+ G +DA+V+ARAGLARLGRL E+TETL
Sbjct: 121 GSPRRVAQLEALGLGLELTGIRGNVDTRIAMVADGKVDAVVLARAGLARLGRLAEITETL 180

Query: 183 DPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVG 242
           DP+QM+PAP QGA+ +ECR+ D+                    ER LLA LEAGC+APVG
Sbjct: 181 DPIQMLPAPGQGALGIECRSDDTAVLAALAPLDDPGTRAAVTAERQLLATLEAGCTAPVG 240

Query: 243 AIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE 300
           A+A+VV+  DG      EL LRG +   DG  V R S   +    + +G A+A EL E
Sbjct: 241 ALAEVVDGEDG-----PELWLRGALGE-DGGGVRRLSANGSVDDPAAVGRALANELLE 292


>tr|C0XUE8|C0XUE8_9CORY Tax_Id=525263 (hemC)SubName:
           Full=Porphobilinogen deaminase;
           EC=2.5.1.61;[Corynebacterium lipophiloflavum DSM 44291]
          Length = 301

 Score =  246 bits (627), Expect = 3e-63
 Identities = 150/310 (48%), Positives = 189/310 (60%), Gaps = 16/310 (5%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           ++ IGTRGS LATTQA  VRD +IA GH AEL IV T GD S A ++ +GVGVFT+ALR 
Sbjct: 1   MLHIGTRGSHLATTQAGHVRDDIIAAGHDAELTIVTTPGDLSQAPVERIGVGVFTSALRD 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+  G V+ AVHS+KDLPTAD+PR  +  +P R D R+A++ RD + LA+LP G+ VGTS
Sbjct: 61  ALFRGEVEIAVHSFKDLPTADEPRAHIV-VPAREDNREALIARDGMQLADLPQGARVGTS 119

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           +P             +IRPLRGN+++R+ RV+SG+LDAIV+A AGL R G  D  T+  D
Sbjct: 120 APRRISQLKALRPDLDIRPLRGNIESRMGRVTSGELDAIVLAYAGLLRAGYGDRATQLFD 179

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
             + +PAPAQGA+AVECR+ D+                    ER +LA LEAGC+APV A
Sbjct: 180 ASEFLPAPAQGALAVECRSDDAETRAVLDPLMDAATALQVSAERHVLATLEAGCTAPVAA 239

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSG------RASELGLAVAVE 297
            A      DG      ELSLR  V ALDGS  +  SG  T         A  LG  +A  
Sbjct: 240 HA----FYDG-----GELSLRAGVFALDGSHQLVESGSVTVADTLDREAARGLGRELASR 290

Query: 298 LFELGARELM 307
           L + GA ELM
Sbjct: 291 LLDAGAAELM 300


>sp|Q8FSF7|HEM3_COREF Tax_Id=152794 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Corynebacterium efficiens]
          Length = 299

 Score =  243 bits (620), Expect = 2e-62
 Identities = 140/303 (46%), Positives = 181/303 (59%), Gaps = 7/303 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGS LATTQA  +RD L   G  AEL IV T GD + + ++ +GVGVFT ALR A
Sbjct: 3   LRIGTRGSKLATTQAGHMRDRLKHFGRDAELTIVTTPGDVNMSPVERIGVGVFTQALRDA 62

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +    +D AVHS+KDLPTA DPRF +  +P R D RDA++ RD L L ELP G+ VGTS+
Sbjct: 63  LVADEIDVAVHSFKDLPTAPDPRFHLV-VPTRADARDALIARDGLTLEELPEGAKVGTSA 121

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EI PLRGN+DTR+ +V+SG+LDA+V+A AGL+R+G  D  T+  DP
Sbjct: 122 PRRISQLKALRPDLEILPLRGNIDTRMGKVTSGELDAVVLAFAGLSRVGMQDRATQVFDP 181

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
             ++PAPAQGA+A+ECR  D                     ER +L  LEAGC+APV A 
Sbjct: 182 DMLMPAPAQGALAIECRVEDEDIITGLNMLMHADTYVTAVAERTVLNRLEAGCTAPVAAH 241

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A +      +G   + ++L   V ALDGS+ +  S      R  EL   VA +L E GA 
Sbjct: 242 ATL------DGYAGDTMTLTAGVFALDGSEQLVFSAQGAGERPEELAEQVAAQLIEQGAA 295

Query: 305 ELM 307
            L+
Sbjct: 296 TLL 298


>tr|C8NSH0|C8NSH0_COREF Tax_Id=196164 (hemC)SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Corynebacterium efficiens YS-314]
          Length = 299

 Score =  243 bits (620), Expect = 2e-62
 Identities = 140/303 (46%), Positives = 181/303 (59%), Gaps = 7/303 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           +RIGTRGS LATTQA  +RD L   G  AEL IV T GD + + ++ +GVGVFT ALR A
Sbjct: 3   LRIGTRGSKLATTQAGHMRDRLKHFGRDAELTIVTTPGDVNMSPVERIGVGVFTQALRDA 62

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +    +D AVHS+KDLPTA DPRF +  +P R D RDA++ RD L L ELP G+ VGTS+
Sbjct: 63  LVADEIDVAVHSFKDLPTAPDPRFHLV-VPTRADARDALIARDGLTLEELPEGAKVGTSA 121

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EI PLRGN+DTR+ +V+SG+LDA+V+A AGL+R+G  D  T+  DP
Sbjct: 122 PRRISQLKALRPDLEILPLRGNIDTRMGKVTSGELDAVVLAFAGLSRVGMQDRATQVFDP 181

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
             ++PAPAQGA+A+ECR  D                     ER +L  LEAGC+APV A 
Sbjct: 182 DMLMPAPAQGALAIECRVEDEDIITGLNMLMHADTYVTAVAERTVLNRLEAGCTAPVAAH 241

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A +      +G   + ++L   V ALDGS+ +  S      R  EL   VA +L E GA 
Sbjct: 242 ATL------DGYAGDTMTLTAGVFALDGSEQLVFSAQGAGERPEELAEQVAAQLIEQGAA 295

Query: 305 ELM 307
            L+
Sbjct: 296 TLL 298


>sp|Q8NT90|HEM3_CORGL Tax_Id=1718 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Corynebacterium glutamicum]
          Length = 302

 Score =  243 bits (619), Expect = 3e-62
 Identities = 143/308 (46%), Positives = 184/308 (59%), Gaps = 8/308 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           ++IGTRGS LATTQA  +RD L   G  AEL IV T GD + + ++ +GVGVFT ALR  
Sbjct: 3   LKIGTRGSKLATTQAGTIRDQLKHYGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDV 62

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +  G  D AVHS KDLPTA DPRF +  +P R D R+A++ RD L LAELP G+ VGTS+
Sbjct: 63  LHSGECDVAVHSMKDLPTATDPRFHLV-VPTRADSREALIARDGLTLAELPEGAKVGTSA 121

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EI PLRGN+DTR+ +V+SG+LDA+++A AGL R+G  D  TE  D 
Sbjct: 122 PRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFDA 181

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
             ++PAPAQGA+A+ECRA D+                    ER +L  LEAGC+APV A 
Sbjct: 182 DIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAH 241

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A +      +G   + ++L   V ALDGSD +  S      R  ELG  VA +L + GA 
Sbjct: 242 ATL------DGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAA 295

Query: 305 ELMWGARS 312
            L+ G RS
Sbjct: 296 NLL-GDRS 302


>sp|A4QB59|HEM3_CORGB Tax_Id=340322 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Corynebacterium glutamicum]
          Length = 302

 Score =  241 bits (616), Expect = 6e-62
 Identities = 143/308 (46%), Positives = 184/308 (59%), Gaps = 8/308 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           ++IGTRGS LATTQA  +RD L   G  AEL IV T GD + + ++ +GVGVFT ALR  
Sbjct: 3   LKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDV 62

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +  G  D AVHS KDLPTA DPRF +  +P R D R+A++ RD L LAELP G+ VGTS+
Sbjct: 63  LHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAKVGTSA 121

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EI PLRGN+DTR+ +V+SG+LDA+++A AGL R+G  D  TE  D 
Sbjct: 122 PRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFDA 181

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
             ++PAPAQGA+A+ECRA D+                    ER +L  LEAGC+APV A 
Sbjct: 182 DIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAH 241

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A +      +G   + ++L   V ALDGSD +  S      R  ELG  VA +L + GA 
Sbjct: 242 ATL------DGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAA 295

Query: 305 ELMWGARS 312
            L+ G RS
Sbjct: 296 NLL-GDRS 302


>tr|Q8GMZ1|Q8GMZ1_CORGL Tax_Id=1718 (hemC)SubName:
           Full=Porphobilinogen deaminase;[Corynebacterium
           glutamicum]
          Length = 302

 Score =  241 bits (616), Expect = 6e-62
 Identities = 143/308 (46%), Positives = 184/308 (59%), Gaps = 8/308 (2%)

Query: 5   IRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAA 64
           ++IGTRGS LATTQA  +RD L   G  AEL IV T GD + + ++ +GVGVFT ALR  
Sbjct: 3   LKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDV 62

Query: 65  IEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSS 124
           +  G  D AVHS KDLPTA DPRF +  +P R D R+A++ RD L LAELP G+ VGTS+
Sbjct: 63  LHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAKVGTSA 121

Query: 125 PXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDP 184
           P             EI PLRGN+DTR+ +V+SG+LDA+++A AGL R+G  D  TE  D 
Sbjct: 122 PRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFDA 181

Query: 185 VQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGAI 244
             ++PAPAQGA+A+ECRA D+                    ER +L  LEAGC+APV A 
Sbjct: 182 DIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAH 241

Query: 245 AQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGAR 304
           A +      +G   + ++L   V ALDGSD +  S      R  ELG  VA +L + GA 
Sbjct: 242 ATL------DGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAA 295

Query: 305 ELMWGARS 312
            L+ G RS
Sbjct: 296 NLL-GDRS 302


>tr|A1SE02|A1SE02_NOCSJ Tax_Id=196162 SubName: Full=Porphobilinogen
           deaminase; EC=2.5.1.61;[Nocardioides sp.]
          Length = 314

 Score =  241 bits (615), Expect = 8e-62
 Identities = 141/307 (45%), Positives = 182/307 (59%), Gaps = 10/307 (3%)

Query: 5   IRIGTRGSLLATTQAALVRDALI-ANGHPAELVIVNTAGDQSSASIDSL----GVGVFTT 59
           +R+GTR S+LATTQ+ LV D L  A G   ELV V+T GD++ A+   L      GVF  
Sbjct: 5   LRVGTRASVLATTQSGLVADQLREALGREVELVTVSTEGDRTQAAGIPLQGGSATGVFVA 64

Query: 60  ALRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSL 119
           ALR A+  G VD AVHS KDLPT      T+AA+P R DPRD VV RD L L ELP GS 
Sbjct: 65  ALRDALLRGEVDVAVHSLKDLPTYPTEGITLAAVPVREDPRDVVVARDGLTLGELPVGSR 124

Query: 120 VGTSSPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVT 179
           VGT SP             E+  +RGN+DTR+ +V SG+ DA+++ARAGLAR+GRL+ VT
Sbjct: 125 VGTGSPRRVAQLHALGLGLEVVGIRGNVDTRIGKVRSGECDAVILARAGLARIGRLEAVT 184

Query: 180 ETLDPVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSA 239
           E LDP+QM+PAP QGA+AVECR  D                     ER +LA LE GCSA
Sbjct: 185 EVLDPLQMLPAPGQGALAVECRTDDPLAAQVAAALDDPRVRAAVTAERAVLATLEGGCSA 244

Query: 240 PVGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELF 299
           P+GA+A++VE  DG     +EL +R    + DG+  +R S   +   A+ +G  +  ++ 
Sbjct: 245 PIGALAEIVEGEDG-----DELWVRSVALSPDGALSVRRSASGSPSDAAGVGTRLGEQML 299

Query: 300 ELGAREL 306
             GA  L
Sbjct: 300 ADGADRL 306


>tr|C6R7U3|C6R7U3_9CORY Tax_Id=553206 (hemC)SubName:
           Full=Hydroxymethylbilane synthase;
           EC=2.5.1.61;[Corynebacterium tuberculostearicum SK141]
          Length = 295

 Score =  239 bits (609), Expect = 4e-61
 Identities = 142/304 (46%), Positives = 190/304 (62%), Gaps = 11/304 (3%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           + +IGTRGS LATTQA  VRD LI  G  ++L IV TAGD + A ++ +GVGVFT ALR 
Sbjct: 1   MFQIGTRGSKLATTQAGHVRDWLIDAGFDSQLHIVTTAGDVNMAPVERIGVGVFTQALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+  G  D AVHS+KDLPTA D RF +  +P R D R+A+V RD L LA+LP G+ VGTS
Sbjct: 61  ALYAGECDIAVHSFKDLPTAPDERFRLV-VPQRQDSREALVARDGLSLAQLPQGARVGTS 119

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           +P             EIRPLRGN+DTR+++V+ G+LDA+++A AGL R G  D  TE  +
Sbjct: 120 APRRISQLAALRPDLEIRPLRGNIDTRMSKVTDGELDAVLLAYAGLLRGGYADRATEIFE 179

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           P   +PAPAQGA+A+E  AG +                    ER +LA LEAGC+APV A
Sbjct: 180 PSVFMPAPAQGALAIEAVAG-TEAAAALDAIVDDRASAAAAGERAVLARLEAGCTAPVAA 238

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
            ++     DG     ++L++RG V ALDGS  + A+   ++  A++LG  ++ ELF  GA
Sbjct: 239 TSR----WDG-----DQLTVRGGVFALDGSRQLTATASGSAAEAADLGARISDELFAGGA 289

Query: 304 RELM 307
            EL+
Sbjct: 290 AELL 293


>tr|C0WI67|C0WI67_9CORY Tax_Id=525260 (hemC)SubName:
           Full=Porphobilinogen deaminase;
           EC=2.5.1.61;[Corynebacterium accolens ATCC 49725]
          Length = 295

 Score =  238 bits (607), Expect = 7e-61
 Identities = 142/304 (46%), Positives = 189/304 (62%), Gaps = 11/304 (3%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           + +IGTRGS LATTQA  VRD LI  G  +EL IV TAGD + A ++ +GVGVFT ALR 
Sbjct: 1   MFQIGTRGSKLATTQAGHVRDWLIDAGFDSELHIVTTAGDTNMAPVERIGVGVFTQALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A+  G  D AVHS+KDLPTA+D RF +  IP R D R+ +V RD + L +LP G+ VGTS
Sbjct: 61  ALCRGECDIAVHSFKDLPTAEDDRFRLV-IPQRQDSREVLVARDGMTLMQLPEGARVGTS 119

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           +P             EIRPLRGN+DTR+++V+ G+LDA+V+A AGL R G  D  ++  D
Sbjct: 120 APRRISQLAALRPDLEIRPLRGNIDTRMSKVTDGELDAVVLAYAGLLRGGYEDRASDIFD 179

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           P   +PAPAQGA+A+E  AG +                    ER +LA LEAGC+APV A
Sbjct: 180 PELFMPAPAQGALAIEAVAG-TEAAAALDAVVDEQATAAALAERAVLARLEAGCTAPVAA 238

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
            ++     +G     ++L++RG V ALDGS  + A+   T+  A+ELG  V+ ELF  GA
Sbjct: 239 TSR----WNG-----DQLTVRGGVFALDGSRQLTATASGTAAEAAELGARVSDELFAQGA 289

Query: 304 RELM 307
            +L+
Sbjct: 290 ADLL 293


>sp|C3PKG2|HEM3_CORA7 Tax_Id=548476 (hemC)RecName:
           Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;
           AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;
           AltName: Full=Pre-uroporphyrinogen
           synthase;[Corynebacterium aurimucosum]
          Length = 296

 Score =  236 bits (603), Expect = 2e-60
 Identities = 138/304 (45%), Positives = 187/304 (61%), Gaps = 11/304 (3%)

Query: 4   VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63
           +++IGTRGSLLATTQ+  V++ L   G+ AEL IV T GD + A ++ +GVGVFT ALR 
Sbjct: 1   MLKIGTRGSLLATTQSGHVQEWLQQKGYEAELHIVTTQGDVNMAPVERIGVGVFTQALRE 60

Query: 64  AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123
           A++ G  + AVHS+KDLPTA D RF +  +P R D R+A++ RD L L ELP G+ VGTS
Sbjct: 61  AVDRGECEIAVHSFKDLPTAADERFDLV-VPQRQDVREALIARDGLTLKELPEGARVGTS 119

Query: 124 SPXXXXXXXXXXXXXEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183
           +P             +IRPLRGN+DTR+ +V+SG+LDA+++A AGL R G  +  TE  D
Sbjct: 120 APRRISQLRAMRPDLDIRPLRGNIDTRMGKVTSGELDAVLLAYAGLVRAGYAERATEVFD 179

Query: 184 PVQMVPAPAQGAIAVECRAGDSXXXXXXXXXXXXXXXXXXXXERVLLAELEAGCSAPVGA 243
           P   +PAPAQGA+A+E   G +                    ER +L++LEAGC+APV A
Sbjct: 180 PEVFMPAPAQGALAIEAVKG-TEAAKAIALLADGPATAATRAERTVLSQLEAGCTAPVAA 238

Query: 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303
            +        EG   E+L +RG V ALDGS  + A     +  A ELG AV+ ELF  GA
Sbjct: 239 TSH------WEG---EQLVVRGGVFALDGSRQLIAQAQGAASEAEELGRAVSKELFAQGA 289

Query: 304 RELM 307
            +++
Sbjct: 290 ADVL 293


  Database: Amellifera_nr
    Posted date:  Jan 15, 2010  5:10 AM
  Number of letters in database: 3,808,957,724
  Number of sequences in database:  11,153,314
  
Lambda     K      H
   0.316    0.133    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 11153314
Number of Hits to DB: 1,855,125,145
Number of extensions: 65362942
Number of successful extensions: 194513
Number of sequences better than 10.0: 1762
Number of HSP's gapped: 190640
Number of HSP's successfully gapped: 1793
Length of query: 318
Length of database: 3,808,957,724
Length adjustment: 137
Effective length of query: 181
Effective length of database: 2,280,953,706
Effective search space: 412852620786
Effective search space used: 412852620786
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 80 (35.4 bits)