BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MSMEG_0954 (610 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 12,507,864 sequences; 4,236,830,644 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|A0QR19|A0QR19_MYCS2 Tax_Id=246196 (hemD)SubName: Full=Uroporp... 976 0.0 tr|A1T3D4|A1T3D4_MYCVP Tax_Id=350058 SubName: Full=Uroporphyrino... 851 0.0 tr|A4T339|A4T339_MYCGI Tax_Id=350054 SubName: Full=Uroporphyrino... 849 0.0 tr|A3PUA5|A3PUA5_MYCSJ Tax_Id=164757 SubName: Full=Uroporphyrino... 832 0.0 tr|Q1BE85|Q1BE85_MYCSS Tax_Id=164756 SubName: Full=Uroporphyrino... 831 0.0 tr|A1UAP9|A1UAP9_MYCSK Tax_Id=189918 SubName: Full=Uroporphyrino... 831 0.0 tr|Q73SR9|Q73SR9_MYCPA Tax_Id=1770 (cysG)SubName: Full=CysG;[Myc... 823 0.0 tr|B2HRJ3|B2HRJ3_MYCMM Tax_Id=216594 (hemD)SubName: Full=Uroporp... 820 0.0 tr|A0PW30|A0PW30_MYCUA Tax_Id=362242 (hemD)SubName: Full=Uroporp... 818 0.0 tr|A0QLH9|A0QLH9_MYCA1 Tax_Id=243243 (hemD)SubName: Full=Uroporp... 808 0.0 tr|Q9CB60|Q9CB60_MYCLE Tax_Id=1769 (hemD)SubName: Full=Possible ... 796 0.0 tr|B8ZT69|B8ZT69_MYCLB Tax_Id=561304 (hemD)SubName: Full=Possibl... 796 0.0 tr|Q7TTP7|Q7TTP7_MYCBO Tax_Id=1765 (hemD)SubName: Full=PROBABLE ... 794 0.0 tr|Q6MX34|Q6MX34_MYCTU Tax_Id=1773 (hemD)SubName: Full=PROBABLE ... 794 0.0 tr|C6DT97|C6DT97_MYCTK Tax_Id=478434 SubName: Full=Uroporphyrin-... 794 0.0 tr|C1AKJ1|C1AKJ1_MYCBT Tax_Id=561275 (hemD)SubName: Full=Putativ... 794 0.0 tr|A5WJM6|A5WJM6_MYCTF Tax_Id=336982 SubName: Full=Uroporphyrin-... 794 0.0 tr|A5TZP1|A5TZP1_MYCTA Tax_Id=419947 (hemD)SubName: Full=Uroporp... 794 0.0 tr|A1KFY7|A1KFY7_MYCBP Tax_Id=410289 (hemD)SubName: Full=Probabl... 794 0.0 tr|Q7D9R0|Q7D9R0_MYCTU Tax_Id=1773 SubName: Full=Uroporphyrin-II... 794 0.0 tr|D6FZ25|D6FZ25_MYCTU Tax_Id=478435 SubName: Full=Uroporphyrin-... 794 0.0 tr|D6FYC2|D6FYC2_MYCTU Tax_Id=611304 SubName: Full=Uroporphyrin-... 794 0.0 tr|D6FE08|D6FE08_MYCTU Tax_Id=611303 SubName: Full=Uroporphyrin-... 794 0.0 tr|D6F1B5|D6F1B5_MYCTU Tax_Id=611302 SubName: Full=Uroporphyrin-... 794 0.0 tr|D5Z090|D5Z090_MYCTU Tax_Id=537209 SubName: Full=Uroporphyrin-... 794 0.0 tr|D5YNF5|D5YNF5_MYCTU Tax_Id=515616 SubName: Full=Uroporphyrin-... 794 0.0 tr|D5YCJ5|D5YCJ5_MYCTU Tax_Id=520140 SubName: Full=Uroporphyrin-... 794 0.0 tr|D5Y0I0|D5Y0I0_MYCTU Tax_Id=520141 SubName: Full=Uroporphyrin-... 794 0.0 tr|D5XQD2|D5XQD2_MYCTU Tax_Id=515617 SubName: Full=Uroporphyrin-... 794 0.0 tr|A4KEJ7|A4KEJ7_MYCTU Tax_Id=395095 SubName: Full=Uroporphyrin-... 794 0.0 tr|A2VFJ6|A2VFJ6_MYCTU Tax_Id=348776 SubName: Full=Uroporphyrin-... 794 0.0 tr|D5PBT8|D5PBT8_9MYCO Tax_Id=525368 (hemD)SubName: Full=Uroporp... 775 0.0 tr|D5ZCN7|D5ZCN7_MYCTU Tax_Id=537210 SubName: Full=Uroporphyrin-... 769 0.0 tr|B1MHI4|B1MHI4_MYCA9 Tax_Id=561007 SubName: Full=Possible Urop... 764 0.0 tr|D5PRX8|D5PRX8_COREQ Tax_Id=525370 (cysG)SubName: Full=Multifu... 726 0.0 tr|Q0SF28|Q0SF28_RHOSR Tax_Id=101510 SubName: Full=Probable urop... 725 0.0 tr|Q5YP71|Q5YP71_NOCFA Tax_Id=37329 (hemDX)SubName: Full=Putativ... 724 0.0 tr|C1AZ42|C1AZ42_RHOOB Tax_Id=632772 (cysGA/hemD)SubName: Full=P... 724 0.0 tr|C0ZUV6|C0ZUV6_RHOE4 Tax_Id=234621 (cysGA/hemD)SubName: Full=U... 719 0.0 tr|C3JK03|C3JK03_RHOER Tax_Id=596309 (hemD)SubName: Full=Uroporp... 719 0.0 tr|D5UT19|D5UT19_TSUPA Tax_Id=521096 SubName: Full=Uroporphyrin-... 707 0.0 tr|C6WNG1|C6WNG1_ACTMD Tax_Id=446462 SubName: Full=Uroporphyrin-... 674 0.0 tr|D0L4A2|D0L4A2_GORB4 Tax_Id=526226 SubName: Full=Uroporphyrin-... 670 0.0 tr|A4FPY2|A4FPY2_SACEN Tax_Id=405948 (hemD)SubName: Full=Uroporp... 658 0.0 tr|C7MT08|C7MT08_SACVD Tax_Id=471857 SubName: Full=Uroporphyrino... 647 0.0 >tr|A0QR19|A0QR19_MYCS2 Tax_Id=246196 (hemD)SubName: Full=Uroporphyrinogen-III synthase; EC=4.2.1.75;[Mycobacterium smegmatis] Length = 610 Score = 976 bits (2523), Expect = 0.0 Identities = 509/610 (83%), Positives = 509/610 (83%) Query: 1 MGGADSLTKXXXXXXXXXXXXXXXXXXXXXXXPASDPQPREXXXXXXXXKVKPGRITFVG 60 MGGADSLTK PASDPQPRE KVKPGRITFVG Sbjct: 1 MGGADSLTKVGGADAAVAVVGAAEGSVGAAESPASDPQPRESSSRSRSRKVKPGRITFVG 60 Query: 61 SGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXXXXXXXXXXX 120 SGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDL Sbjct: 61 SGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLPPAAGPAPAKKNDKADKAT 120 Query: 121 XXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGD 180 VIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGD Sbjct: 121 DKSDKSDKADKADDAKSDDPAVIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGD 180 Query: 181 PLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRGDVDWXXXX 240 PLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRGDVDW Sbjct: 181 PLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRGDVDWAALA 240 Query: 241 XXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLVGLTDKTVV 300 TASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLVGLTDKTVV Sbjct: 241 AAPGPLILHATASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLVGLTDKTVV 300 Query: 301 EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLV 360 EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLV Sbjct: 301 EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLV 360 Query: 361 THGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDA 420 THGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDA Sbjct: 361 THGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDA 420 Query: 421 RAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRVLLPR 480 RAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRVLLPR Sbjct: 421 RAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRVLLPR 480 Query: 481 ADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTVRNL 540 ADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTVRNL Sbjct: 481 ADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTVRNL 540 Query: 541 VGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXXXXXXXXXXX 600 VGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLV Sbjct: 541 VGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVEALAEHAARLRAEGAL 600 Query: 601 PPPRKKSRRR 610 PPPRKKSRRR Sbjct: 601 PPPRKKSRRR 610 >tr|A1T3D4|A1T3D4_MYCVP Tax_Id=350058 SubName: Full=Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium vanbaalenii] Length = 571 Score = 851 bits (2198), Expect = 0.0 Identities = 441/565 (78%), Positives = 469/565 (83%), Gaps = 4/565 (0%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K KPGRITFVGSGPGDPGLLTTRA+AVLAHA LVFTDPDVPEAVL LVG++L Sbjct: 7 KGKPGRITFVGSGPGDPGLLTTRARAVLAHAALVFTDPDVPEAVLELVGSELPPPSGPLP 66 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---VIPGGPEVRPALGDPAEVAKTLASE 166 VIPGGP+VRPALGDP EVAKTLA+E Sbjct: 67 PVAAGAAPKPADAVVKQDADAAEKPAEGSKAAEDAVIPGGPDVRPALGDPVEVAKTLATE 126 Query: 167 ARHGYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHT 226 AR G +VVRL+AGDPLS+D+VITEINALAKT L FEIVPGLP T+AVPTYAGLPLGSSHT Sbjct: 127 ARTGVDVVRLVAGDPLSIDSVITEINALAKTQLNFEIVPGLPGTSAVPTYAGLPLGSSHT 186 Query: 227 VADVRG-DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQR 285 VADVR +VDW TASHLP+AARTLIE+GL ++TPAVVTANGTTCQQR Sbjct: 187 VADVRDPNVDWAALAAAPGPLILHATASHLPEAARTLIEYGLADSTPAVVTANGTTCQQR 246 Query: 286 SVETTLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLV 345 S+ETTL GL DK V++KPA +E GPLTG LVVT+G+TVA+RAKLNWWESRALYGWTVLV Sbjct: 247 SIETTLGGLLDKAVLDKPAVAEPAGPLTGTLVVTLGRTVAHRAKLNWWESRALYGWTVLV 306 Query: 346 PRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 405 PRTKDQAGEMS+RLV HGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA Sbjct: 307 PRTKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 366 Query: 406 VRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPP 465 VRAVWEKFNEFGLDARAFSGVKIACVGQATA++VRAFGINPELVP+GEQSSLGLLDEFPP Sbjct: 367 VRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPP 426 Query: 466 YDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGG 525 YD++FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGG Sbjct: 427 YDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIKTGG 486 Query: 526 FDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVX 585 FDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETA EFGLRVDVQPE AAVGPLV Sbjct: 487 FDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVE 546 Query: 586 XXXXXXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 547 ALAEHAARLRAEGALPPPRKKSRRR 571 >tr|A4T339|A4T339_MYCGI Tax_Id=350054 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium gilvum] Length = 569 Score = 849 bits (2194), Expect = 0.0 Identities = 443/566 (78%), Positives = 466/566 (82%), Gaps = 8/566 (1%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K KPGRITFVGSGPGDPGLLT+RA+AVLA+A LVFTDPDVPEAV ALVG++L Sbjct: 7 KNKPGRITFVGSGPGDPGLLTSRARAVLANAALVFTDPDVPEAVRALVGSELPPPSGPLP 66 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----VIPGGPEVRPALGDPAEVAKTLA 164 VIPGGP+VRPALGDPAEVAKTLA Sbjct: 67 PVADAAPKTAAAGADQPASQDAAPADAAKTAKAAEDAVIPGGPDVRPALGDPAEVAKTLA 126 Query: 165 SEARHGYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSS 224 EAR G +VVRL+AGDPLS D+VITE+NALAKT L+FEIVPGLP T+AVPTYAGLPLGSS Sbjct: 127 HEARTGVDVVRLVAGDPLSNDSVITEVNALAKTQLSFEIVPGLPGTSAVPTYAGLPLGSS 186 Query: 225 HTVADVRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQ 284 HTVADVRGDVDW T SHLP+AARTLIE+GL E+TPAVVTANGTTCQQ Sbjct: 187 HTVADVRGDVDWAALAAAPGPLILHATPSHLPEAARTLIEYGLAESTPAVVTANGTTCQQ 246 Query: 285 RSVETTLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVL 344 RSVETTL GL DK + AG+E GPLTG LVVTIG+TVANRAKLNWWESRALYGWTVL Sbjct: 247 RSVETTLAGLLDKAAL---AGTEPAGPLTGTLVVTIGRTVANRAKLNWWESRALYGWTVL 303 Query: 345 VPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 404 VPRTKDQAGEMS+RLV HGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN Sbjct: 304 VPRTKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 363 Query: 405 AVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFP 464 AVRAVWEKFNEFGLDARAFSGVKIACVGQATA+KVRAFGINPELVP+GEQSSLGLLDEFP Sbjct: 364 AVRAVWEKFNEFGLDARAFSGVKIACVGQATAEKVRAFGINPELVPTGEQSSLGLLDEFP 423 Query: 465 PYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTG 524 PYD++FDPVNRVLLPRADIATETLAEGLRE GWEIEDVTAYRTVRAAPPPAHTREMIKTG Sbjct: 424 PYDDIFDPVNRVLLPRADIATETLAEGLRELGWEIEDVTAYRTVRAAPPPAHTREMIKTG 483 Query: 525 GFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLV 584 GFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETA EFGLRVDVQPE AAVGPLV Sbjct: 484 GFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLV 543 Query: 585 XXXXXXXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 544 EALAEHAARLRAEGALPPPRKKSRRR 569 >tr|A3PUA5|A3PUA5_MYCSJ Tax_Id=164757 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium sp.] Length = 554 Score = 832 bits (2148), Expect = 0.0 Identities = 430/563 (76%), Positives = 457/563 (81%), Gaps = 21/563 (3%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K+KPGRITFVGSGPGDPGLLT RA +VL +A LVFTDPDVPEAVL+LVG L Sbjct: 11 KMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSGPEP 70 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 IPGGP++RPALGDPAEVAK LA EA+H Sbjct: 71 AEPADAADEQAGS-------------------TIPGGPDIRPALGDPAEVAKVLAGEAKH 111 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPLSVDAVI E+NALAK+H FEIVPGLP+TTAVPTYAGLPLGS+HTVAD Sbjct: 112 GVDVVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVAD 171 Query: 230 VRG-DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVE 288 VR +VDW TASHLPDAARTLIE+GL E TPAVVTANGTTCQQRSVE Sbjct: 172 VRDPNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVE 231 Query: 289 TTLVGLTDKTVVEKP-AGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPR 347 +TL GL DK + P A PL GPLVVT+G+TV NRA+LNWWESRALYGWTVLVPR Sbjct: 232 STLFGLLDKAALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPR 291 Query: 348 TKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 407 TKDQAGEMS++LV HGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR Sbjct: 292 TKDQAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 351 Query: 408 AVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYD 467 AVWEKFNEFGLDARAFSGVKIACVGQATA++VRAFGINPELVP+GEQSSLGLLDEFPPYD Sbjct: 352 AVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYD 411 Query: 468 EVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFD 527 ++FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFD Sbjct: 412 DIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFD 471 Query: 528 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXX 587 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETA EFGLRVDVQPE AAVGPLV Sbjct: 472 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEAL 531 Query: 588 XXXXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 532 AEHAARLRAEGALPPPRKKSRRR 554 >tr|Q1BE85|Q1BE85_MYCSS Tax_Id=164756 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium sp.] Length = 554 Score = 831 bits (2147), Expect = 0.0 Identities = 430/563 (76%), Positives = 457/563 (81%), Gaps = 21/563 (3%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K+KPGRITFVGSGPGDPGLLT RA +VL +A LVFTDPDVPEAVL+LVG L Sbjct: 11 KMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSGPEP 70 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 IPGGP++RPALGDPAEVAK LA EA+H Sbjct: 71 AEPADAADEQAGS-------------------TIPGGPDIRPALGDPAEVAKVLAGEAKH 111 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPLSVDAVI E+NALAK+H FEIVPGLP+TTAVPTYAGLPLGS+HTVAD Sbjct: 112 GVDVVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVAD 171 Query: 230 VRG-DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVE 288 VR +VDW TASHLPDAARTLIE+GL E TPAVVTANGTTCQQRSVE Sbjct: 172 VRDPNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVE 231 Query: 289 TTLVGLTDKTVVEKP-AGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPR 347 +TL GL DK + P A PL GPLVVT+G+TV NRA+LNWWESRALYGWTVLVPR Sbjct: 232 STLSGLLDKAALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPR 291 Query: 348 TKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 407 TKDQAGEMS++LV HGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR Sbjct: 292 TKDQAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 351 Query: 408 AVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYD 467 AVWEKFNEFGLDARAFSGVKIACVGQATA++VRAFGINPELVP+GEQSSLGLLDEFPPYD Sbjct: 352 AVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYD 411 Query: 468 EVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFD 527 ++FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFD Sbjct: 412 DIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFD 471 Query: 528 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXX 587 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETA EFGLRVDVQPE AAVGPLV Sbjct: 472 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEAL 531 Query: 588 XXXXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 532 AEHAARLRAEGALPPPRKKSRRR 554 >tr|A1UAP9|A1UAP9_MYCSK Tax_Id=189918 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium sp.] Length = 554 Score = 831 bits (2147), Expect = 0.0 Identities = 430/563 (76%), Positives = 457/563 (81%), Gaps = 21/563 (3%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K+KPGRITFVGSGPGDPGLLT RA +VL +A LVFTDPDVPEAVL+LVG L Sbjct: 11 KMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSGPEP 70 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 IPGGP++RPALGDPAEVAK LA EA+H Sbjct: 71 AEPADAADEQAGS-------------------TIPGGPDIRPALGDPAEVAKVLAGEAKH 111 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPLSVDAVI E+NALAK+H FEIVPGLP+TTAVPTYAGLPLGS+HTVAD Sbjct: 112 GVDVVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVAD 171 Query: 230 VRG-DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVE 288 VR +VDW TASHLPDAARTLIE+GL E TPAVVTANGTTCQQRSVE Sbjct: 172 VRDPNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVE 231 Query: 289 TTLVGLTDKTVVEKP-AGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPR 347 +TL GL DK + P A PL GPLVVT+G+TV NRA+LNWWESRALYGWTVLVPR Sbjct: 232 STLSGLLDKAALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPR 291 Query: 348 TKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 407 TKDQAGEMS++LV HGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR Sbjct: 292 TKDQAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 351 Query: 408 AVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYD 467 AVWEKFNEFGLDARAFSGVKIACVGQATA++VRAFGINPELVP+GEQSSLGLLDEFPPYD Sbjct: 352 AVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYD 411 Query: 468 EVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFD 527 ++FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFD Sbjct: 412 DIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFD 471 Query: 528 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXX 587 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETA EFGLRVDVQPE AAVGPLV Sbjct: 472 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEAL 531 Query: 588 XXXXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 532 AEHAARLRAEGALPPPRKKSRRR 554 >tr|Q73SR9|Q73SR9_MYCPA Tax_Id=1770 (cysG)SubName: Full=CysG;[Mycobacterium paratuberculosis] Length = 552 Score = 823 bits (2125), Expect = 0.0 Identities = 425/561 (75%), Positives = 454/561 (80%), Gaps = 15/561 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K PGRIT+VGSGPGDPGLLT RA VLA+A LVFTDPDVPE VLAL+G DL Sbjct: 7 KPTPGRITYVGSGPGDPGLLTARAATVLANAALVFTDPDVPEPVLALIGKDLPPVSGPAP 66 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 VI GGP++RPALGDPAEVAKTL +EAR Sbjct: 67 AEPASNGEGSGSEQGQAQPA------------VISGGPDIRPALGDPAEVAKTLTAEART 114 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVITE+NA+A++HL EIVPGL T AVPTYAGLPLGSSHT+AD Sbjct: 115 GVDVVRLVAGDPLTVDAVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMAD 174 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRGDVDW TASHL DAARTLIEH L ENTP VVTA+GTTCQQRS+ET Sbjct: 175 VRGDVDWEALAAAPGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIET 234 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL GLTD V+ G++ GPLTGPLVVTIGKTV+ R KLNWWESRALYGWTVLVPRTK Sbjct: 235 TLQGLTDSAVL---GGTDPAGPLTGPLVVTIGKTVSARTKLNWWESRALYGWTVLVPRTK 291 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQAGEMSERL ++GALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV Sbjct: 292 DQAGEMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 351 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVP+GEQSSLGLLD+FPPYD V Sbjct: 352 WEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSV 411 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 412 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAV 471 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQPETAAVGPLV Sbjct: 472 CFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAE 531 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 532 HAARLRAEGALPPPRKKSRRR 552 >tr|B2HRJ3|B2HRJ3_MYCMM Tax_Id=216594 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase HemD;[Mycobacterium marinum] Length = 558 Score = 820 bits (2119), Expect = 0.0 Identities = 419/561 (74%), Positives = 456/561 (81%), Gaps = 9/561 (1%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRIT+VGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE+VLAL+G DL Sbjct: 7 KPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPPVSGPAP 66 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GP++RPALGDP EVAKTL +EAR Sbjct: 67 ATAVADNADAATGGPAEGESDQAVPA------VVSSGPDIRPALGDPTEVAKTLTAEARS 120 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDP+SVDAVI E+NA+ ++HL EI+PGL T+AVPTYAGLPLGS+HTVAD Sbjct: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRGDVDW TASHL DAARTL+EH L + TP VVTA+GTTCQQRSVET Sbjct: 181 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL GLTD ++ G++ GPLTGPLVVTIGKTV+NRAKLNWWESRALYGWTVLVPRTK Sbjct: 241 TLQGLTDPAIL---GGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTK 297 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV Sbjct: 298 DQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 357 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVP+GEQSSLGLLDEFPPYD + Sbjct: 358 WEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSI 417 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 418 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAV 477 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQPETAAVGPLV Sbjct: 478 CFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAE 537 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 538 HAARLRAEGALPPPRKKSRRR 558 >tr|A0PW30|A0PW30_MYCUA Tax_Id=362242 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase HemD;[Mycobacterium ulcerans] Length = 557 Score = 818 bits (2113), Expect = 0.0 Identities = 418/561 (74%), Positives = 455/561 (81%), Gaps = 9/561 (1%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRIT+VGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE+VLAL+G DL Sbjct: 6 KPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GP++RPALGDP EVAKTL +EAR Sbjct: 66 ATAVADNADAATGGPAEGESDQAVPA------VVSSGPDIRPALGDPTEVAKTLTAEARS 119 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDP+SVDAVI E+NA+ ++HL EI+PGL T+AVPTYAGLPLGS+HTVAD Sbjct: 120 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 179 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRGDVDW TASHL DAARTL+EH L + TP VVTA+GTTCQQRSVET Sbjct: 180 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 239 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL GLTD ++ G++ GPLTGPLVVTIGKTV+NRAKLNWWESRALYGWTVLVPRTK Sbjct: 240 TLQGLTDPAIL---GGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTK 296 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQAGEMSERL ++GALP+EVPTIAV PPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV Sbjct: 297 DQAGEMSERLTSYGALPVEVPTIAVAPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 356 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVP+GEQSSLGLLDEFPPYD + Sbjct: 357 WEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSI 416 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 417 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAV 476 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQPETAAVGPLV Sbjct: 477 CFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAE 536 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 537 HAARLRAEGALPPPRKKSRRR 557 >tr|A0QLH9|A0QLH9_MYCA1 Tax_Id=243243 (hemD)SubName: Full=Uroporphyrinogen-III synthase; EC=4.2.1.75;[Mycobacterium avium] Length = 537 Score = 808 bits (2088), Expect = 0.0 Identities = 419/552 (75%), Positives = 448/552 (81%), Gaps = 15/552 (2%) Query: 59 VGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXXXXXXXXX 118 +GSGPGDPGLLT RA AVLA+A LVFTDPDVPE VLAL+G DL Sbjct: 1 MGSGPGDPGLLTARAAAVLANAALVFTDPDVPEPVLALIGKDLPPVSGPAPAEPAPNGEG 60 Query: 119 XXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIA 178 VI GGP++RPALGDPAEVAKTL +EAR G +VVRL+A Sbjct: 61 AGSEQGQAQPA------------VISGGPDIRPALGDPAEVAKTLTAEARTGVDVVRLVA 108 Query: 179 GDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRGDVDWXX 238 GDPL+VDAVITE+NA+A++HL EIVPGL T AVPTYAGLPLGSSHT+ADVRGDVDW Sbjct: 109 GDPLTVDAVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRGDVDWEA 168 Query: 239 XXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLVGLTDKT 298 TASHL DAARTLIEH L ENTP VVTA+GTTCQQRS+ETTL GLTD Sbjct: 169 LAAAPGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIETTLQGLTDSA 228 Query: 299 VVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQAGEMSER 358 V+ G++ GPLTGPLVVTIGKTV+ RAKLNWWESRALYGWTVLVPRTKDQAGEMSER Sbjct: 229 VL---GGTDPAGPLTGPLVVTIGKTVSARAKLNWWESRALYGWTVLVPRTKDQAGEMSER 285 Query: 359 LVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGL 418 L ++GALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF EFGL Sbjct: 286 LTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGL 345 Query: 419 DARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRVLL 478 DARAFSGVKIACVG++TAD+VRAFGI+PELVP+GEQSSLGLLD+FP YD VFDPVNRVLL Sbjct: 346 DARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPLYDSVFDPVNRVLL 405 Query: 479 PRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTVR 538 PRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVR Sbjct: 406 PRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVR 465 Query: 539 NLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXXXXXXXXX 598 NLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQPETAAVGPLV Sbjct: 466 NLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAEG 525 Query: 599 XXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 526 ALPPPRKKSRRR 537 >tr|Q9CB60|Q9CB60_MYCLE Tax_Id=1769 (hemD)SubName: Full=Possible uroporphyrin-III C-methyltransferase;[Mycobacterium leprae] Length = 563 Score = 796 bits (2055), Expect = 0.0 Identities = 412/561 (73%), Positives = 447/561 (79%), Gaps = 9/561 (1%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K++PGRITFVG+GPG PGLLT +A AVLA+A LVF DPDVPE VLAL+G DL Sbjct: 12 KLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKDLPPVSGPAP 71 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GG ++RPALGDP EVAKTL +EAR Sbjct: 72 AGPAAVTAGRAADGTLEGDHYQAAPM------VMSGGADIRPALGDPTEVAKTLTAEARS 125 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI E+NA+A+T+L EIVPGL ++ VPTYAGLPLGSSHTVAD Sbjct: 126 GVDVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVAD 185 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRGDVDW TASHL DAA LI+HGL + TP VVTA GTTCQQRSVET Sbjct: 186 VRGDVDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVET 245 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL GL D V+ G++ GPLTGPLVVTIGKTV +RA+LNWWESRALYGWTVLVPRTK Sbjct: 246 TLEGLADSAVL---VGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPRTK 302 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV Sbjct: 303 DQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 362 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIACVG+ATAD+VRAFGI+PELVP+GEQSSLGLLDEFPPYD V Sbjct: 363 WEKFGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSV 422 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLR GWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 423 FDPVNRVLLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAV 482 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQPETAAVGPLV Sbjct: 483 CFTSSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDALAE 542 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 543 HVARLRAEGALPPPRKKSRRR 563 >tr|B8ZT69|B8ZT69_MYCLB Tax_Id=561304 (hemD)SubName: Full=Possible uroporphyrin-III C-methyltransferase;[Mycobacterium leprae] Length = 563 Score = 796 bits (2055), Expect = 0.0 Identities = 412/561 (73%), Positives = 447/561 (79%), Gaps = 9/561 (1%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K++PGRITFVG+GPG PGLLT +A AVLA+A LVF DPDVPE VLAL+G DL Sbjct: 12 KLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKDLPPVSGPAP 71 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GG ++RPALGDP EVAKTL +EAR Sbjct: 72 AGPAAVTAGRAADGTLEGDHYQAAPM------VMSGGADIRPALGDPTEVAKTLTAEARS 125 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI E+NA+A+T+L EIVPGL ++ VPTYAGLPLGSSHTVAD Sbjct: 126 GVDVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVAD 185 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRGDVDW TASHL DAA LI+HGL + TP VVTA GTTCQQRSVET Sbjct: 186 VRGDVDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVET 245 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL GL D V+ G++ GPLTGPLVVTIGKTV +RA+LNWWESRALYGWTVLVPRTK Sbjct: 246 TLEGLADSAVL---VGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPRTK 302 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV Sbjct: 303 DQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 362 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIACVG+ATAD+VRAFGI+PELVP+GEQSSLGLLDEFPPYD V Sbjct: 363 WEKFGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSV 422 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLR GWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 423 FDPVNRVLLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAV 482 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQPETAAVGPLV Sbjct: 483 CFTSSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDALAE 542 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 543 HVARLRAEGALPPPRKKSRRR 563 >tr|Q7TTP7|Q7TTP7_MYCBO Tax_Id=1765 (hemD)SubName: Full=PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM); EC=2.1.1.107;[Mycobacterium bovis] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|Q6MX34|Q6MX34_MYCTU Tax_Id=1773 (hemD)SubName: Full=PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM); EC=2.1.1.107;[Mycobacterium tuberculosis] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|C6DT97|C6DT97_MYCTK Tax_Id=478434 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis] Length = 568 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 9 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 68 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 69 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 121 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 122 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 181 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 182 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 241 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 242 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 301 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 302 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 361 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 362 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 421 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 422 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 481 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 482 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 541 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 542 VDALAEHAARLRAEGALPPPRKKSRRR 568 >tr|C1AKJ1|C1AKJ1_MYCBT Tax_Id=561275 (hemD)SubName: Full=Putative uroporphyrin-III C-methyltransferase; EC=2.1.1.107;[Mycobacterium bovis] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A5WJM6|A5WJM6_MYCTF Tax_Id=336982 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A5TZP1|A5TZP1_MYCTA Tax_Id=419947 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase;[Mycobacterium tuberculosis] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A1KFY7|A1KFY7_MYCBP Tax_Id=410289 (hemD)SubName: Full=Probable uroporphyrin-III c-methyltransferase hemD; EC=2.1.1.107;[Mycobacterium bovis] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|Q7D9R0|Q7D9R0_MYCTU Tax_Id=1773 SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107;[Mycobacterium tuberculosis] Length = 568 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 9 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 68 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 69 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 121 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 122 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 181 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 182 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 241 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 242 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 301 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 302 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 361 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 362 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 421 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 422 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 481 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 482 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 541 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 542 VDALAEHAARLRAEGALPPPRKKSRRR 568 >tr|D6FZ25|D6FZ25_MYCTU Tax_Id=478435 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis KZN 605] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D6FYC2|D6FYC2_MYCTU Tax_Id=611304 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis K85] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D6FE08|D6FE08_MYCTU Tax_Id=611303 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis CPHL_A] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D6F1B5|D6F1B5_MYCTU Tax_Id=611302 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis T46] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D5Z090|D5Z090_MYCTU Tax_Id=537209 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis GM 1503] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D5YNF5|D5YNF5_MYCTU Tax_Id=515616 SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase;[Mycobacterium tuberculosis 02_1987] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D5YCJ5|D5YCJ5_MYCTU Tax_Id=520140 SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase;[Mycobacterium tuberculosis EAS054] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D5Y0I0|D5Y0I0_MYCTU Tax_Id=520141 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis T85] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|D5XQD2|D5XQD2_MYCTU Tax_Id=515617 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis T92] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A4KEJ7|A4KEJ7_MYCTU Tax_Id=395095 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis str. Haarlem] Length = 565 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A2VFJ6|A2VFJ6_MYCTU Tax_Id=348776 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis C] Length = 568 Score = 794 bits (2050), Expect = 0.0 Identities = 411/567 (72%), Positives = 452/567 (79%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 9 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 68 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 69 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 121 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 122 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 181 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 182 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 241 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 242 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 301 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 302 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 361 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGLLD+F Sbjct: 362 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 421 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 422 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 481 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 482 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 541 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 542 VDALAEHAARLRAEGALPPPRKKSRRR 568 >tr|D5PBT8|D5PBT8_9MYCO Tax_Id=525368 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107;[Mycobacterium parascrofulaceum ATCC BAA-614] Length = 522 Score = 775 bits (2001), Expect = 0.0 Identities = 406/543 (74%), Positives = 434/543 (79%), Gaps = 22/543 (4%) Query: 69 LTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXXXXXXXXXXXXXXXXXXX 128 +TTRA VLA+A LVFTDPDVPE VLAL+G DL Sbjct: 1 MTTRAATVLANAALVFTDPDVPEPVLALIGKDLPPVSGPAPAGGDAATGGAEQPA----- 55 Query: 129 XXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGDPLSVDAVI 188 VI GP+VRPALG+PAEVAKTL +EAR G +VVRL+AGDPL+VDAVI Sbjct: 56 -------------VISAGPDVRPALGEPAEVAKTLTAEARTGADVVRLVAGDPLTVDAVI 102 Query: 189 TEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRG-DVDWXXXXXXXXXXX 247 TE+NA+AK+HL EIVPGL AVPTYAGLPLGSSHTVADVR VDW Sbjct: 103 TEVNAVAKSHLHLEIVPGLAPAGAVPTYAGLPLGSSHTVADVRDPQVDWDALAAAPGPLI 162 Query: 248 XXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLVGLTDKTVVEKPAGSE 307 T SHL DAARTLIEH L E TP VVTA+GTTCQQRS+ETTL GLTD V+ G++ Sbjct: 163 LQATTSHLADAARTLIEHELAETTPCVVTAHGTTCQQRSIETTLGGLTDSAVL---GGTD 219 Query: 308 LLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLVTHGALPI 367 GPLTGPLVVTIGKTVA+RAKLNWWESRALYGWTVLVPRTKDQAGEMSERL ++GALPI Sbjct: 220 PAGPLTGPLVVTIGKTVASRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPI 279 Query: 368 EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGVK 427 EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF EFGLDARAFSGVK Sbjct: 280 EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVK 339 Query: 428 IACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRVLLPRADIATET 487 IACVG++TAD+VRAFGI+PELVP+GEQSSLGLLD+FPPYD +FDPVNRVLLPRADIATET Sbjct: 340 IACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSIFDPVNRVLLPRADIATET 399 Query: 488 LAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTVRNLVGIAGKP 547 LAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVRNLVGIAGKP Sbjct: 400 LAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVRNLVGIAGKP 459 Query: 548 HARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXXXXXXXXXXXPPPRKKS 607 HARTI+ACIGPKTAETA EFGLRVDVQPETAAVGPLV PPPRKKS Sbjct: 460 HARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAEGALPPPRKKS 519 Query: 608 RRR 610 RRR Sbjct: 520 RRR 522 >tr|D5ZCN7|D5ZCN7_MYCTU Tax_Id=537210 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis T17] Length = 565 Score = 769 bits (1985), Expect = 0.0 Identities = 400/567 (70%), Positives = 443/567 (78%), Gaps = 13/567 (2%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDL Sbjct: 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 V+ GGP++RPALGDPA+VAKTL +EAR Sbjct: 66 AEPVAGNGDAAGGGSAQEHGRAASA-------VVSGGPDIRPALGDPADVAKTLTAEARS 118 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSHTVAD Sbjct: 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 Query: 230 VRGD---VDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRS 286 VR D DW TASHL ++AR+LI+H L E+TP VVTA+GTTCQQRS Sbjct: 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 Query: 287 VETTLVGLTDKTVV---EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTV 343 VETTL GLTD V+ + + GPL+VTIGKTV +RAKLNWWESRALYGWTV Sbjct: 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 Query: 344 LVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 403 LVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 Query: 404 NAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEF 463 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+ A+ + +GEQSSLGLLD+F Sbjct: 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADREAAYYAQRQRPAAGEQSSLGLLDDF 418 Query: 464 PPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKT 523 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKT Sbjct: 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 Query: 524 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPL 583 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct: 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 Query: 584 VXXXXXXXXXXXXXXXXPPPRKKSRRR 610 V PPPRKKSRRR Sbjct: 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 >tr|B1MHI4|B1MHI4_MYCA9 Tax_Id=561007 SubName: Full=Possible Uroporphyrin-III C-methyltransferase;[Mycobacterium abscessus] Length = 549 Score = 764 bits (1974), Expect = 0.0 Identities = 394/559 (70%), Positives = 437/559 (78%), Gaps = 16/559 (2%) Query: 52 KPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXX 111 KPGRI FVGSGPGDPGLLT RA+AVL A + FTDPDVP+AVL LVG+ + Sbjct: 7 KPGRILFVGSGPGDPGLLTVRARAVLTGATVAFTDPDVPQAVLDLVGSAVELPEPAPAKP 66 Query: 112 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGY 171 P ++RPALGDPA+VAKTL +EAR G Sbjct: 67 ATGGDEAPAAADNEAAAEP-------------PLTIDIRPALGDPADVAKTLVAEARSGV 113 Query: 172 NVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVR 231 +VVRL+AGDPLS+D+V+ E++A+ +T + FEI+PGL +TAVP YAGLP GS+HTVADVR Sbjct: 114 DVVRLVAGDPLSIDSVLAEVHAVTRTQVAFEILPGLASSTAVPAYAGLPPGSAHTVADVR 173 Query: 232 GDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTL 291 GDVDW T +H+PDAA+ LIEHGL + T VTA GTTC QR+VETTL Sbjct: 174 GDVDWAALAAAPGPLILHATPTHVPDAAKALIEHGLADQTLVAVTAQGTTCAQRTVETTL 233 Query: 292 VGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQ 351 L D V+ ++ GP+TG LV+TIG+ VA R+KLNWWESRALYGWTVLVPRTKDQ Sbjct: 234 ASLIDGVPVD---ANDPHGPMTGALVLTIGRVVAGRSKLNWWESRALYGWTVLVPRTKDQ 290 Query: 352 AGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWE 411 AGEMS++LV +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAVWE Sbjct: 291 AGEMSDKLVGYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWE 350 Query: 412 KFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFD 471 KF EFGLDARAFSGVKIACVGQATADKVRAFGINPELVP+GEQSSLGLLDEFPPYD+VFD Sbjct: 351 KFAEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPAGEQSSLGLLDEFPPYDDVFD 410 Query: 472 PVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCF 531 PVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPP A TREMIKTGGFDAVCF Sbjct: 411 PVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPAAQTREMIKTGGFDAVCF 470 Query: 532 TSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXX 591 TSSSTVRNLVGIAGKPHARTIVACIGPKTAETA+EFGLRVDVQPETAAVGPLV Sbjct: 471 TSSSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPETAAVGPLVEALAEHA 530 Query: 592 XXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 531 ARLRTEGALPPPRKKSRRR 549 >tr|D5PRX8|D5PRX8_COREQ Tax_Id=525370 (cysG)SubName: Full=Multifunctional enzyme siroheme synthase CysG; EC=2.1.1.107;[Rhodococcus equi ATCC 33707] Length = 521 Score = 726 bits (1874), Expect = 0.0 Identities = 377/561 (67%), Positives = 423/561 (75%), Gaps = 46/561 (8%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K PGRI FVGSGPGDP LLT RA VLA A L FTDPDV + V ALVGT L Sbjct: 6 KNSPGRILFVGSGPGDPALLTVRAHDVLASAALAFTDPDVDKGVTALVGTALGRDPETDL 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 EVRPALG+PAEVAKTL +EA++ Sbjct: 66 PIA-----------------------------------EVRPALGEPAEVAKTLVAEAKN 90 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G++VVRL++GDPL+ D+VI E++A+A+T + FE++PGLP +AVP+YAG+ LGS HT AD Sbjct: 91 GHDVVRLVSGDPLTTDSVIAEVSAVARTQVVFEVLPGLPSGSAVPSYAGMALGSGHTEAD 150 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRG+VDW T++HL + A L+EHGL TPA +T GTT QQR+VE Sbjct: 151 VRGEVDWAALAAAPGPLVLHATSAHLAETASALVEHGLAPQTPAAITVRGTTRQQRTVEA 210 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL L D AGSEL+GPL +VT+GK V+ R K++WWESRALYGWTVLVPRTK Sbjct: 211 TLATLND-------AGSELVGPL----IVTVGKVVSQRNKMSWWESRALYGWTVLVPRTK 259 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 +QA +MS+RLVTHGA+PIEVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAV Sbjct: 260 EQAADMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAV 319 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF FGLDARAFSGVKIACVG+ATA+KVR+FGI PELVPSGEQSS GLL +FPPYDEV Sbjct: 320 WEKFEAFGLDARAFSGVKIACVGEATAEKVRSFGITPELVPSGEQSSEGLLADFPPYDEV 379 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 380 FDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAV 439 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETA +GPLV Sbjct: 440 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAQMGPLVEALAE 499 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSR R Sbjct: 500 HAARLRAEGALPPPRKKSRAR 520 >tr|Q0SF28|Q0SF28_RHOSR Tax_Id=101510 SubName: Full=Probable uroporphiryn-III C-methyltransferase; EC=2.1.1.107;[Rhodococcus sp.] Length = 521 Score = 725 bits (1872), Expect = 0.0 Identities = 381/563 (67%), Positives = 421/563 (74%), Gaps = 50/563 (8%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K PGRI FVGSGPGDP LLT A+ VLA A L FTDPDV + V LVGTDL Sbjct: 6 KNTPGRILFVGSGPGDPALLTVHARDVLAAATLAFTDPDVDKGVTVLVGTDLGVDAET-- 63 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGP--EVRPALGDPAEVAKTLASEA 167 G P EVRPALG+PAEVAKTL EA Sbjct: 64 -----------------------------------GEPLAEVRPALGEPAEVAKTLVHEA 88 Query: 168 RHGYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTV 227 R+G++VVRL++GDPL+ D+VI E+ A+A+T + FE++PGLP +AVP+YAG+ LGS HT Sbjct: 89 RNGHDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSASAVPSYAGMALGSGHTE 148 Query: 228 ADVRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSV 287 ADVRG+VDW T+ HL + A L+EHGL TPA +T GTT QQR+V Sbjct: 149 ADVRGEVDWAALAAAPGPLVLHATSGHLAETASALVEHGLAPQTPAAITVRGTTRQQRTV 208 Query: 288 ETTLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPR 347 E TL L + AGSEL+G L VVT+GK VA R K++WWESRALYGW VLVPR Sbjct: 209 EATLATLNE-------AGSELVGSL----VVTVGKVVAQRNKMSWWESRALYGWKVLVPR 257 Query: 348 TKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 407 TKDQAGEMS+RLVTHGA+PIEVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVR Sbjct: 258 TKDQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVR 317 Query: 408 AVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYD 467 AVWEKF EFGLDARAFSGVKIAC+G+ATA KVR+FGINPELVPSGEQSS GLL EF PYD Sbjct: 318 AVWEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELVPSGEQSSEGLLAEFAPYD 377 Query: 468 EVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFD 527 +VFDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGGFD Sbjct: 378 DVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFD 437 Query: 528 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXX 587 AVCFTSSSTVRNLVGIAGKPHART+VACIGPKTAETAIEFGLRVDVQPETA VGPLV Sbjct: 438 AVCFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETAQVGPLVEAL 497 Query: 588 XXXXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSR R Sbjct: 498 AEHAARLRAEGALPPPRKKSRAR 520 >tr|Q5YP71|Q5YP71_NOCFA Tax_Id=37329 (hemDX)SubName: Full=Putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase;[Nocardia farcinica] Length = 520 Score = 724 bits (1869), Expect = 0.0 Identities = 375/560 (66%), Positives = 422/560 (75%), Gaps = 47/560 (8%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K PGRI FVGSGPGDP LLT RA+ VL A L FTDPDV + VLAL+GT + Sbjct: 6 KKHPGRILFVGSGPGDPALLTVRAREVLGRATLAFTDPDVDKGVLALIGTAVEPNEDGTS 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 +VRPALG+PAEVAKTL +EAR Sbjct: 66 PV------------------------------------DVRPALGEPAEVAKTLIAEARG 89 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G++VVR++AGDPL+ D+VITE+ A+ ++H+ FE++PGLP+ +AVP+YAG+ LGS HT AD Sbjct: 90 GHDVVRVVAGDPLTTDSVITEVTAVTRSHMVFEVLPGLPNGSAVPSYAGIALGSGHTEAD 149 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRG+VDW T+ HL + A L+EHG+ TP VT GTT QQR++E Sbjct: 150 VRGEVDWAALAAAPGPLVLHATSGHLAETASALVEHGMAPQTPVAVTVRGTTRQQRTIEA 209 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL L A SEL+GPL VVTIGK VA+R+K++WWESRALYGWTVLVPRTK Sbjct: 210 TLATLNS-------AASELVGPL----VVTIGKVVASRSKMSWWESRALYGWTVLVPRTK 258 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQA EMSERLVTHGA+P+EVPTIAVEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAV Sbjct: 259 DQAAEMSERLVTHGAIPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAV 318 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIACVG+ATADKVR+FGINPELVPSGEQSS GLL +FPPYD+V Sbjct: 319 WEKFAEFGLDARAFSGVKIACVGEATADKVRSFGINPELVPSGEQSSEGLLADFPPYDDV 378 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLR+RGWEI+DVTAYRTVRA+PPPA TREMIKTGGFDAV Sbjct: 379 FDPVNRVLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRASPPPAETREMIKTGGFDAV 438 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 FTSSSTVRNLVGIAGKPHARTIVACIGPKTAETA+EFGLRVDVQPE A VGPLV Sbjct: 439 LFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPEVAQVGPLVEALAE 498 Query: 590 XXXXXXXXXXXPPPRKKSRR 609 PPPRKKSRR Sbjct: 499 HAARLRAEGLLPPPRKKSRR 518 >tr|C1AZ42|C1AZ42_RHOOB Tax_Id=632772 (cysGA/hemD)SubName: Full=Putative uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Rhodococcus opacus] Length = 521 Score = 724 bits (1869), Expect = 0.0 Identities = 380/563 (67%), Positives = 421/563 (74%), Gaps = 50/563 (8%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K PGRI FVGSGPGDP LLT A+ VLA A L FTDPDV + V LVGTDL Sbjct: 6 KNTPGRILFVGSGPGDPALLTVHARDVLAAATLAFTDPDVDKGVTVLVGTDLGVDAET-- 63 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGP--EVRPALGDPAEVAKTLASEA 167 G P EVRPALG+PAEVAKTL EA Sbjct: 64 -----------------------------------GEPLAEVRPALGEPAEVAKTLVHEA 88 Query: 168 RHGYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTV 227 ++G++VVRL++GDPL+ D+VI E+ A+A+T + FE++PGLP +AVP+YAG+ LGS HT Sbjct: 89 KNGHDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSASAVPSYAGMALGSGHTE 148 Query: 228 ADVRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSV 287 ADVRG+VDW T+ HL + A L+EHGL TPA +T GTT QQR+V Sbjct: 149 ADVRGEVDWAALAAAPGPLVLHATSGHLAETASALVEHGLAPQTPAAITVRGTTRQQRTV 208 Query: 288 ETTLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPR 347 E TL L + AGSEL+G L VVT+GK VA R K++WWESRALYGW VLVPR Sbjct: 209 EATLATLNE-------AGSELVGSL----VVTVGKVVAQRNKMSWWESRALYGWKVLVPR 257 Query: 348 TKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 407 TKDQAGEMS+RLVTHGA+PIEVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVR Sbjct: 258 TKDQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVR 317 Query: 408 AVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYD 467 AVWEKF EFGLDARAFSGVKIAC+G+ATA KVR+FGINPELVPSGEQSS GLL EF PYD Sbjct: 318 AVWEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELVPSGEQSSEGLLAEFAPYD 377 Query: 468 EVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFD 527 +VFDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGGFD Sbjct: 378 DVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFD 437 Query: 528 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXX 587 AVCFTSSSTVRNLVGIAGKPHART+VACIGPKTAETAIEFGLRVDVQPETA VGPLV Sbjct: 438 AVCFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETAQVGPLVEAL 497 Query: 588 XXXXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSR R Sbjct: 498 AEHAARLRAEGALPPPRKKSRAR 520 >tr|C0ZUV6|C0ZUV6_RHOE4 Tax_Id=234621 (cysGA/hemD)SubName: Full=Uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Rhodococcus erythropolis] Length = 520 Score = 719 bits (1857), Expect = 0.0 Identities = 372/561 (66%), Positives = 422/561 (75%), Gaps = 46/561 (8%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K PGRI FVGSGPGDP LLT RA+ VL A + FTDPDV + V+ALVG D+ Sbjct: 6 KNTPGRILFVGSGPGDPALLTVRARDVLTGAAMAFTDPDVDKGVVALVGIDMGRDEETGE 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 +VRPALG+PAEVAKTL EA++ Sbjct: 66 LIA-----------------------------------DVRPALGEPAEVAKTLVHEAKN 90 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G++VVRL++GDPL+ D+VI E+ A+A+T + FE++PGLP +AVP+YAG+ LGS HT AD Sbjct: 91 GHDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSGSAVPSYAGMALGSGHTEAD 150 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRG+VDW T+ HL + A L+E+GL TPA +T GTT QQR+VE Sbjct: 151 VRGEVDWAALAAAPGPLVLHATSGHLAETASALVENGLAPQTPAAITVRGTTRQQRTVEA 210 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL L + AGSEL+G L +VT+GK VA R K++WWESRALYGWTVLVPRTK Sbjct: 211 TLATLNE-------AGSELVGSL----IVTVGKVVAQRNKMSWWESRALYGWTVLVPRTK 259 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQAGEMS+RLVTHGA+PIEVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAV Sbjct: 260 DQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAV 319 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIAC+G+ATA KVR+FGINPEL+P+GEQSS GLL EF PYD+V Sbjct: 320 WEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELIPTGEQSSEGLLAEFAPYDDV 379 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 380 FDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAV 439 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHART+VACIGPKTAETAIEFGLRVDVQPET+ VGPLV Sbjct: 440 CFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETSQVGPLVEALAE 499 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 500 HAARLRAEGALPPPRKKSRRR 520 >tr|C3JK03|C3JK03_RHOER Tax_Id=596309 (hemD)SubName: Full=Uroporphyrinogen-III synthase; EC=4.2.1.75;[Rhodococcus erythropolis SK121] Length = 520 Score = 719 bits (1857), Expect = 0.0 Identities = 372/561 (66%), Positives = 422/561 (75%), Gaps = 46/561 (8%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXX 109 K PGRI FVGSGPGDP LLT RA+ VL A + FTDPDV + V+ALVG D+ Sbjct: 6 KNTPGRILFVGSGPGDPALLTVRARDVLTGAAMAFTDPDVDKGVVALVGIDMGRDEETGE 65 Query: 110 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARH 169 +VRPALG+PAEVAKTL EA++ Sbjct: 66 LIA-----------------------------------DVRPALGEPAEVAKTLVHEAKN 90 Query: 170 GYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVAD 229 G++VVRL++GDPL+ D+VI E+ A+A+T + FE++PGLP +AVP+YAG+ LGS HT AD Sbjct: 91 GHDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSGSAVPSYAGMALGSGHTEAD 150 Query: 230 VRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVET 289 VRG+VDW T+ HL + A L+E+GL TPA +T GTT QQR+VE Sbjct: 151 VRGEVDWAALAAAPGPLVLHATSGHLAETASALVENGLAPQTPAAITVRGTTRQQRTVEA 210 Query: 290 TLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK 349 TL L + AGSEL+G L +VT+GK VA R K++WWESRALYGWTVLVPRTK Sbjct: 211 TLATLNE-------AGSELVGSL----IVTVGKVVAQRNKMSWWESRALYGWTVLVPRTK 259 Query: 350 DQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 409 DQAGEMS+RLVTHGA+PIEVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAV Sbjct: 260 DQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAV 319 Query: 410 WEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEV 469 WEKF EFGLDARAFSGVKIAC+G+ATA KVR+FGINPEL+P+GEQSS GLL EF PYD+V Sbjct: 320 WEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELIPTGEQSSEGLLAEFAPYDDV 379 Query: 470 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAV 529 FDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGGFDAV Sbjct: 380 FDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAV 439 Query: 530 CFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXX 589 CFTSSSTVRNLVGIAGKPHART+VACIGPKTAETAIEFGLRVDVQPET+ VGPLV Sbjct: 440 CFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETSQVGPLVEALAE 499 Query: 590 XXXXXXXXXXXPPPRKKSRRR 610 PPPRKKSRRR Sbjct: 500 HAARLRAEGALPPPRKKSRRR 520 >tr|D5UT19|D5UT19_TSUPA Tax_Id=521096 SubName: Full=Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase;[Tsukamurella paurometabola DSM 20162] Length = 567 Score = 707 bits (1824), Expect = 0.0 Identities = 363/557 (65%), Positives = 412/557 (73%), Gaps = 27/557 (4%) Query: 53 PGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXXX 112 PGRITFVGSGPGDPGLLT RAQ +A A V+TDPDVP VL +VG +L Sbjct: 35 PGRITFVGSGPGDPGLLTLRAQQTIAQARTVYTDPDVPATVLEMVGAELPVEPIETDADA 94 Query: 113 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGYN 172 V PALG+PAEVAKTL ++ARHG + Sbjct: 95 PAAEPAKGRKAEP----------------AFRNPATVAPALGEPAEVAKTLLTQARHGQD 138 Query: 173 VVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRG 232 VVRL+AGDP+S DAV+ EI+A+A+T + FE++PGL TAVP YAG+ LGS+HTVADVRG Sbjct: 139 VVRLVAGDPMSSDAVLAEIHAVARTQIAFEVIPGLSTATAVPAYAGMALGSAHTVADVRG 198 Query: 233 DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLV 292 +VDW TA HL DAA L+E+GL TP VT G+TC+Q++++ TL Sbjct: 199 EVDWAALAAAPSPLVLGATAEHLADAASALVENGLAPQTPVAVTTQGSTCKQKTLDATLA 258 Query: 293 GLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQA 352 L +E+ L GPLV+T+GK V R+KL+WWESRALYGWTVLVPRTKDQA Sbjct: 259 TL-----------NEVAAGLPGPLVITVGKVVGTRSKLSWWESRALYGWTVLVPRTKDQA 307 Query: 353 GEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 412 +MS RL HGA+P+EVPTIAVEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAVWEK Sbjct: 308 ADMSNRLRGHGAIPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEK 367 Query: 413 FNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDP 472 F EFGLDARAFSGVKIACVG+ TA KVRAFGI PEL+P+GEQSSLG+L+ FPP+D+VFDP Sbjct: 368 FTEFGLDARAFSGVKIACVGEQTAAKVRAFGIEPELLPTGEQSSLGMLEVFPPFDDVFDP 427 Query: 473 VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFT 532 VNRVLLPRADIATETLAEGLR+RGWEI+DVTAYRTVRAAPPPA TREMIKTG FDAVCFT Sbjct: 428 VNRVLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRAAPPPASTREMIKTGDFDAVCFT 487 Query: 533 SSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXXX 592 SSSTVRNLVGIAGKPH+RTIVACIGPKTAETAIEFGLRVDVQPETA+V LV Sbjct: 488 SSSTVRNLVGIAGKPHSRTIVACIGPKTAETAIEFGLRVDVQPETASVEDLVEALAAHAS 547 Query: 593 XXXXXXXXPPPRKKSRR 609 PPPRKK RR Sbjct: 548 RLRAEGTLPPPRKKPRR 564 >tr|C6WNG1|C6WNG1_ACTMD Tax_Id=446462 SubName: Full=Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase;[Actinosynnema mirum] Length = 510 Score = 674 bits (1738), Expect = 0.0 Identities = 352/558 (63%), Positives = 403/558 (72%), Gaps = 57/558 (10%) Query: 53 PGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXXX 112 PGR+ FVGSGPGD GLLT RA+ +L AELV TDPDVP V+ALV Sbjct: 8 PGRVAFVGSGPGDTGLLTVRARDLLGKAELVVTDPDVPAEVVALV--------------- 52 Query: 113 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGYN 172 P G EVRPA+G+PA+VAK L +EA++G Sbjct: 53 -------------------------------PDGVEVRPAVGEPADVAKDLVAEAKNGAA 81 Query: 173 VVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRG 232 VVRL+AGDPL++D+V+ E +A++KT + F++VPG+P TAVP YAG+ LG+ HT ADVRG Sbjct: 82 VVRLVAGDPLTLDSVVKEAHAVSKTTIAFDVVPGVPAGTAVPAYAGVALGAVHTEADVRG 141 Query: 233 DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLV 292 VDW T HL +AA +L+EHGL TP VTA+GT QR+V+TTL Sbjct: 142 AVDWAGLASATGTLVLHATGGHLAEAASSLVEHGLAPQTPVAVTADGTGFSQRTVDTTLA 201 Query: 293 GLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQA 352 L G L+GPLVVT+G VANR KL+WWESRALYGW VLVPRTK+QA Sbjct: 202 SLAADA-----------GELSGPLVVTVGSAVANRPKLSWWESRALYGWRVLVPRTKEQA 250 Query: 353 GEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 412 G MS+RL +HGA+P+EVPTI+VEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAVWEK Sbjct: 251 GAMSDRLHSHGAIPVEVPTISVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAVWEK 310 Query: 413 FNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDP 472 F EFGLDARAFSGVKIACVG+ATA KVR FGI PELVPSGEQSS GLL +FPPYD++ DP Sbjct: 311 FREFGLDARAFSGVKIACVGEATAAKVRGFGIIPELVPSGEQSSEGLLADFPPYDDILDP 370 Query: 473 VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFT 532 V+RVLLPRADIATETLA GLR+RGWEI+DVTAYRTVRAAPPPA TREMIK+GGFDAVCFT Sbjct: 371 VDRVLLPRADIATETLAAGLRDRGWEIDDVTAYRTVRAAPPPADTREMIKSGGFDAVCFT 430 Query: 533 SSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXXX 592 SSSTVRNLVGIAGKPHART+VACIGP+TAETA EFGLRVDVQPE A V LV Sbjct: 431 SSSTVRNLVGIAGKPHARTLVACIGPQTAETAREFGLRVDVQPEDANVPALVDALAQHAA 490 Query: 593 XXXXXXXXPPPRKKSRRR 610 PPPRK R R Sbjct: 491 RLRAEGALPPPRKTKRLR 508 >tr|D0L4A2|D0L4A2_GORB4 Tax_Id=526226 SubName: Full=Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase;[Gordonia bronchialis] Length = 577 Score = 670 bits (1729), Expect = 0.0 Identities = 332/466 (71%), Positives = 379/466 (81%), Gaps = 12/466 (2%) Query: 144 PGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGDPLSVDAVITEINALAKTHLTFEI 203 P P V PALGDPAEVAKTL + A+ G +VVR+++GDPL+ D+V+ E+NA+A+T + FE+ Sbjct: 121 PDSP-VHPALGDPAEVAKTLVAAAKAGDDVVRVVSGDPLTTDSVLGEVNAVARTSVAFEV 179 Query: 204 VPGLPDTTAVPTYAGLPLGSSHTVADVRGDVDWXXXXXXXXXXXXXXTASHLPDAARTLI 263 +PGLP + VP+YAG+PLGS+HT ADVRG+VDW T+ HL + A L Sbjct: 180 LPGLPAASVVPSYAGMPLGSTHTEADVRGEVDWAALAAAPGPLVLHATSGHLAETASALT 239 Query: 264 EHGLVENTPAVVTANGTTCQQRSVETTLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKT 323 EHG+ TP +T NGTTCQQR++E TL L ++ LTGPL++TIG Sbjct: 240 EHGMAAQTPVAITVNGTTCQQRTIEATLASLNEQG-----------NALTGPLILTIGNV 288 Query: 324 VANRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQM 383 V+ R KL+WWESRALYGWTVLVPRTKDQA +MSERLV+HGA+P EVPTIAVEPPRSPAQM Sbjct: 289 VSARGKLSWWESRALYGWTVLVPRTKDQAADMSERLVSHGAVPKEVPTIAVEPPRSPAQM 348 Query: 384 ERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFG 443 ERAVKGLVDGR+QWVVFTSTNAVRAVWEKF EFGLDARAFSGVKIACVG+ATA++VR+FG Sbjct: 349 ERAVKGLVDGRYQWVVFTSTNAVRAVWEKFAEFGLDARAFSGVKIACVGEATAERVRSFG 408 Query: 444 INPELVPSGEQSSLGLLDEFPPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVT 503 INPEL+PSGEQSSLGLLDEFPPYD+VFDPVNR+LLPRADIATETL+EGLRERGWEI+DVT Sbjct: 409 INPELIPSGEQSSLGLLDEFPPYDDVFDPVNRILLPRADIATETLSEGLRERGWEIDDVT 468 Query: 504 AYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAET 563 AYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAET Sbjct: 469 AYRTVRAAPPPAATREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAET 528 Query: 564 AIEFGLRVDVQPETAAVGPLVXXXXXXXXXXXXXXXXPPPRKKSRR 609 A EFGLRVDVQPETA++ LV PPPRKKSRR Sbjct: 529 ATEFGLRVDVQPETASIPDLVDALAEHAARLRAEGALPPPRKKSRR 574 Score = 71.6 bits (174), Expect = 3e-10 Identities = 32/50 (64%), Positives = 39/50 (78%) Query: 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGT 99 K PGRI FVGSGPGDP LLT RA+ V+AHA + DPDVP AV++L+G+ Sbjct: 7 KSNPGRILFVGSGPGDPDLLTVRARTVIAHATTAYIDPDVPAAVISLIGS 56 >tr|A4FPY2|A4FPY2_SACEN Tax_Id=405948 (hemD)SubName: Full=Uroporphyrinogen III synthase/methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Saccharopolyspora erythraea] Length = 510 Score = 658 bits (1697), Expect = 0.0 Identities = 345/558 (61%), Positives = 391/558 (70%), Gaps = 57/558 (10%) Query: 53 PGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXXX 112 PGRI FVGSGPGD GLLT RA+ V+ A LV TDPDVP ++ L Sbjct: 8 PGRIAFVGSGPGDAGLLTVRARHVITSASLVVTDPDVPADIVGLAAE------------- 54 Query: 113 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGYN 172 G EVRPA+GDPA+VA LA+EA+ G Sbjct: 55 ---------------------------------GAEVRPAVGDPADVALDLANEAKTGRP 81 Query: 173 VVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRG 232 VVRL+AGDPL+ DAV+ E+ A+AKT + F+IVPG+P +AVP YAG+ LG+ H DVRG Sbjct: 82 VVRLVAGDPLTADAVVREVQAVAKTDVAFDIVPGVPAGSAVPAYAGVALGAVHAEVDVRG 141 Query: 233 DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLV 292 DVDW +HL +AA L+EHG TP VTA+GTT QQR+++TTL Sbjct: 142 DVDWASLAKVPGALVLHTAGTHLAEAASALVEHGRAAQTPVAVTASGTTVQQRTIDTTLA 201 Query: 293 GLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQA 352 L G L G LVVTIG V+ R L+WWESRALYGW VLVPRTK+QA Sbjct: 202 SLAADA-----------GELQGQLVVTIGDVVSERNSLSWWESRALYGWKVLVPRTKEQA 250 Query: 353 GEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 412 G MSERL +HGA+ EVPTI+VEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAVWEK Sbjct: 251 GSMSERLWSHGAVSHEVPTISVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEK 310 Query: 413 FNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDP 472 F EFGLDARAFSGVKIACVG+ATA+KVR+FGINPELVPSGEQSS GLL +FPP+D++ DP Sbjct: 311 FREFGLDARAFSGVKIACVGEATAEKVRSFGINPELVPSGEQSSEGLLQDFPPHDDILDP 370 Query: 473 VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFT 532 V+RVLLPRADIATETLA GLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGGFDAVCFT Sbjct: 371 VDRVLLPRADIATETLAAGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFT 430 Query: 533 SSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXXX 592 S+STVRNLVGIAGKPHART+VACIGP TAETA EFGLRVDVQPE + LV Sbjct: 431 SASTVRNLVGIAGKPHARTLVACIGPSTAETAKEFGLRVDVQPEVPQIPVLVDALAEHAA 490 Query: 593 XXXXXXXXPPPRKKSRRR 610 PPP+K R R Sbjct: 491 RLRAEGALPPPKKAKRAR 508 >tr|C7MT08|C7MT08_SACVD Tax_Id=471857 SubName: Full=Uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase;[Saccharomonospora viridis] Length = 516 Score = 647 bits (1668), Expect = 0.0 Identities = 338/558 (60%), Positives = 394/558 (70%), Gaps = 58/558 (10%) Query: 54 GRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLXXXXXXXXXXXX 113 GR+ FVGSGPGD GLLT RA+ +LA A+LV TDPDVP VLA G + Sbjct: 9 GRVAFVGSGPGDAGLLTVRARDLLAKADLVVTDPDVPAGVLAYAGPEA------------ 56 Query: 114 XXXXXXXXXXXXXXXXXXXXXXXXXXXXVIPGGPEVRPALGDPAEVAKTLASEARHGYNV 173 EVRPA+G+P +VAK LA+EA+ G V Sbjct: 57 ----------------------------------EVRPAVGEPGDVAKDLATEAKAGRLV 82 Query: 174 VRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVR-G 232 +RL +GDPL+ AVI E+ A+++T+ F++VPG+P TA P YAG+ LG T D+R G Sbjct: 83 LRLTSGDPLTQQAVIAEVQAVSRTNAVFDVVPGVPAGTATPAYAGIALGGVRTEVDLRSG 142 Query: 233 DVDWXXXXXXXXXXXXXXTASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLV 292 +VDW T+SHL +AA L+EHG+ + TP VT+NGT QR++++TL Sbjct: 143 EVDWAKLASAPGAIVLHATSSHLAEAASALVEHGMSDQTPVAVTSNGTINTQRTLDSTLA 202 Query: 293 GLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQA 352 L G L GPLVVTIG+ V+NR KL+WWESRALYGW VLVPRTK+QA Sbjct: 203 SLAADA-----------GELVGPLVVTIGEPVSNRQKLSWWESRALYGWKVLVPRTKEQA 251 Query: 353 GEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 412 G+M+ER+++HGA P EVPTI+VEPPRSPAQMERAVKGLVDGR+QW+VFTS NAVRAVWEK Sbjct: 252 GDMAERILSHGATPHEVPTISVEPPRSPAQMERAVKGLVDGRYQWLVFTSANAVRAVWEK 311 Query: 413 FNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDP 472 FNEFGLDARAFSGVKIACVG+ATAD+VR+FGI PELVP GEQSS GLL EFPPYD+V DP Sbjct: 312 FNEFGLDARAFSGVKIACVGEATADRVRSFGIIPELVPKGEQSSEGLLQEFPPYDDVLDP 371 Query: 473 VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFT 532 VNRVLLPRADIATE L+ GL+ERGWE++DVTAYRTVRAAPPPA TREMIKTGGFDAVCFT Sbjct: 372 VNRVLLPRADIATEILSAGLQERGWEVDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFT 431 Query: 533 SSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVXXXXXXXX 592 SSSTVRNLVGIAGKPHART+VACIGPKTAETA EFGLRVDV+PE LV Sbjct: 432 SSSTVRNLVGIAGKPHARTLVACIGPKTAETATEFGLRVDVRPEQPNAVMLVDALAEHAA 491 Query: 593 XXXXXXXXPPPRKKSRRR 610 PPPRK R R Sbjct: 492 KLRAEGALPPPRKAKRTR 509 Database: Amellifera_nr Posted date: Jul 23, 2010 5:10 AM Number of letters in database: 4,236,830,644 Number of sequences in database: 12,507,864 Lambda K H 0.316 0.134 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 12507864 Number of Hits to DB: 4,399,746,632 Number of extensions: 172890458 Number of successful extensions: 440436 Number of sequences better than 10.0: 3313 Number of HSP's gapped: 437465 Number of HSP's successfully gapped: 4834 Length of query: 610 Length of database: 4,236,830,644 Length adjustment: 144 Effective length of query: 466 Effective length of database: 2,435,698,228 Effective search space: 1135035374248 Effective search space used: 1135035374248 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 84 (37.0 bits)