BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MSMEG_2387 (484 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 12,507,864 sequences; 4,236,830,644 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|A0QUY9|A0QUY9_MYCS2 Tax_Id=246196 (leuC)RecName: Full=3-isopr... 970 0.0 sp|A1T700|LEUC_MYCVP Tax_Id=350058 (leuC)RecName: Full=3-isoprop... 877 0.0 sp|A4TE23|LEUC_MYCGI Tax_Id=350054 (leuC)RecName: Full=3-isoprop... 876 0.0 sp|A3PXR2|LEUC_MYCSJ Tax_Id=164757 (leuC)RecName: Full=3-isoprop... 869 0.0 sp|Q1BAQ4|LEUC_MYCSS Tax_Id=164756 (leuC)RecName: Full=3-isoprop... 868 0.0 sp|A1UEA8|LEUC_MYCSK Tax_Id=189918 (leuC)RecName: Full=3-isoprop... 868 0.0 sp|Q73VI7|LEUC_MYCPA Tax_Id=1770 (leuC)RecName: Full=3-isopropyl... 847 0.0 sp|A0QJB7|LEUC_MYCA1 Tax_Id=243243 (leuC)RecName: Full=3-isoprop... 846 0.0 sp|Q5YRY0|LEUC_NOCFA Tax_Id=37329 (leuC)RecName: Full=3-isopropy... 840 0.0 sp|B1MDQ1|LEUC_MYCA9 Tax_Id=561007 (leuC)RecName: Full=3-isoprop... 832 0.0 sp|O33123|LEUC_MYCLE Tax_Id=1769 (leuC)RecName: Full=3-isopropyl... 827 0.0 tr|B8ZS12|B8ZS12_MYCLB Tax_Id=561304 (leuC)RecName: Full=3-isopr... 827 0.0 sp|B2HII1|LEUC_MYCMM Tax_Id=216594 (leuC)RecName: Full=3-isoprop... 827 0.0 tr|D5PIY5|D5PIY5_9MYCO Tax_Id=525368 (leuC)SubName: Full=3-isopr... 827 0.0 tr|C1B2N0|C1B2N0_RHOOB Tax_Id=632772 (leuC)SubName: Full=3-isopr... 826 0.0 sp|O53237|LEUC_MYCTU Tax_Id=1773 (leuC)RecName: Full=3-isopropyl... 822 0.0 sp|A5U6Z9|LEUC_MYCTA Tax_Id=419947 (leuC)RecName: Full=3-isoprop... 822 0.0 tr|C6DW61|C6DW61_MYCTK Tax_Id=478434 (leuC)RecName: Full=3-isopr... 822 0.0 tr|A5WRP1|A5WRP1_MYCTF Tax_Id=336982 (leuC)RecName: Full=3-isopr... 822 0.0 tr|D6G1I5|D6G1I5_MYCTU Tax_Id=478435 SubName: Full=3-isopropylma... 822 0.0 tr|D6F8C6|D6F8C6_MYCTU Tax_Id=611302 SubName: Full=3-isopropylma... 822 0.0 tr|D5ZKI9|D5ZKI9_MYCTU Tax_Id=537210 SubName: Full=3-isopropylma... 822 0.0 tr|D5Z7H5|D5Z7H5_MYCTU Tax_Id=537209 SubName: Full=3-isopropylma... 822 0.0 tr|D5YVS6|D5YVS6_MYCTU Tax_Id=515616 SubName: Full=3-isopropylma... 822 0.0 tr|D5YIU9|D5YIU9_MYCTU Tax_Id=520140 SubName: Full=Isopropylmala... 822 0.0 tr|D5Y783|D5Y783_MYCTU Tax_Id=520141 SubName: Full=Isopropylmala... 822 0.0 tr|D5XXZ1|D5XXZ1_MYCTU Tax_Id=515617 SubName: Full=3-isopropylma... 822 0.0 tr|A4KKP4|A4KKP4_MYCTU Tax_Id=395095 (leuC)RecName: Full=3-isopr... 822 0.0 tr|A2VLV9|A2VLV9_MYCTU Tax_Id=348776 (leuC)RecName: Full=3-isopr... 822 0.0 sp|A0PPZ6|LEUC_MYCUA Tax_Id=362242 (leuC)RecName: Full=3-isoprop... 822 0.0 tr|D5PQ46|D5PQ46_COREQ Tax_Id=525370 (leuC)SubName: Full=3-isopr... 822 0.0 sp|C1AGA3|LEUC_MYCBT Tax_Id=561275 (leuC)RecName: Full=3-isoprop... 821 0.0 sp|A1KMY2|LEUC_MYCBP Tax_Id=410289 (leuC)RecName: Full=3-isoprop... 821 0.0 sp|Q7TXH6|LEUC_MYCBO Tax_Id=1765 (leuC)RecName: Full=3-isopropyl... 821 0.0 tr|D6FPW2|D6FPW2_MYCTU Tax_Id=611304 SubName: Full=3-isopropylma... 821 0.0 tr|C0ZXN1|C0ZXN1_RHOE4 Tax_Id=234621 (leuC)RecName: Full=3-isopr... 819 0.0 tr|D6FKM8|D6FKM8_MYCTU Tax_Id=611303 SubName: Full=3-isopropylma... 819 0.0 tr|Q0S2G4|Q0S2G4_RHOSR Tax_Id=101510 (leuC2)SubName: Full=3-isop... 818 0.0 tr|C3JSK4|C3JSK4_RHOER Tax_Id=596309 (leuC)RecName: Full=3-isopr... 818 0.0 tr|C7MXF5|C7MXF5_SACVD Tax_Id=471857 (leuC)RecName: Full=3-isopr... 800 0.0 tr|D0LC33|D0LC33_GORB4 Tax_Id=526226 (leuC)RecName: Full=3-isopr... 799 0.0 tr|D3LP98|D3LP98_MICLU Tax_Id=596312 (leuC)SubName: Full=3-isopr... 796 0.0 tr|C6WG49|C6WG49_ACTMD Tax_Id=446462 (leuC)RecName: Full=3-isopr... 791 0.0 tr|C5CAC8|C5CAC8_MICLC Tax_Id=465515 (leuC)RecName: Full=3-isopr... 790 0.0 tr|D5UTG1|D5UTG1_TSUPA Tax_Id=521096 SubName: Full=3-isopropylma... 788 0.0 >tr|A0QUY9|A0QUY9_MYCS2 Tax_Id=246196 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Mycobacterium smegmatis] Length = 484 Score = 970 bits (2508), Expect = 0.0 Identities = 484/484 (100%), Positives = 484/484 (100%) Query: 1 MDQPTQTSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRL 60 MDQPTQTSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRL Sbjct: 1 MDQPTQTSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRL 60 Query: 61 AGRPVRRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQG 120 AGRPVRRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQG Sbjct: 61 AGRPVRRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQG 120 Query: 121 IVHIIGPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTM 180 IVHIIGPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTM Sbjct: 121 IVHIIGPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTM 180 Query: 181 AVNVDGELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEA 240 AVNVDGELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEA Sbjct: 181 AVNVDGELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEA 240 Query: 241 GARAGMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSP 300 GARAGMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSP Sbjct: 241 GARAGMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSP 300 Query: 301 FVTWGTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGS 360 FVTWGTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGS Sbjct: 301 FVTWGTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGS 360 Query: 361 CTNGRIEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAG 420 CTNGRIEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAG Sbjct: 361 CTNGRIEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAG 420 Query: 421 CSMCLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLP 480 CSMCLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLP Sbjct: 421 CSMCLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLP 480 Query: 481 AAAR 484 AAAR Sbjct: 481 AAAR 484 >sp|A1T700|LEUC_MYCVP Tax_Id=350058 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium vanbaalenii] Length = 481 Score = 877 bits (2267), Expect = 0.0 Identities = 427/472 (90%), Positives = 450/472 (95%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEKVW DHVV G GEG A+EPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD Sbjct: 6 QPRTLAEKVWSDHVVVAGTGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 65 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LTIATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRLHPMGD EQGIVHIIGPQL Sbjct: 66 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHIIGPQL 125 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG+LP Sbjct: 126 GLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGQLP 185 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAI SLSMEGRMT+CNMSIEAGARAGM+AP Sbjct: 186 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGMIAP 245 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETTFEFL+GRPHAPKGA+WDAAVA W +LRTDEGA+FDTE+YIDASTLSPFVTWGTNPG Sbjct: 246 DETTFEFLRGRPHAPKGAEWDAAVAVWRQLRTDEGAQFDTEIYIDASTLSPFVTWGTNPG 305 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPLS+ VPDPEL+ DE RQAAEKALAYMDLR GTPMR I VDTVFVGSCTNGRIEDL Sbjct: 306 QGVPLSDPVPDPELMFDEAERQAAEKALAYMDLRAGTPMRQIPVDTVFVGSCTNGRIEDL 365 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVAD+LRGR+VAD VRML+VPGSMRVRAQAESEGL +IFTAAGA+WRQAGCSMCLGMNP Sbjct: 366 RVVADILRGRRVADNVRMLVVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNP 425 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPA 481 DQL+PGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L+SPADL A Sbjct: 426 DQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLAA 477 >sp|A4TE23|LEUC_MYCGI Tax_Id=350054 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium gilvum] Length = 481 Score = 876 bits (2264), Expect = 0.0 Identities = 427/472 (90%), Positives = 449/472 (95%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEKVW DHVV G GEG A+EPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD Sbjct: 6 QPRTLAEKVWSDHVVVSGSGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 65 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LTIATEDHNVPT+DIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGD EQGIVHIIGPQL Sbjct: 66 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDVEQGIVHIIGPQL 125 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPG TVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDGELP Sbjct: 126 GLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELP 185 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 PGVSAKD+ILAVIAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGM+AP Sbjct: 186 PGVSAKDVILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMIAP 245 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETTFEFLKGRPHAP+GADWDAAV AW LRTDEGA+FDTEVYIDA++LSPFVTWGTNPG Sbjct: 246 DETTFEFLKGRPHAPQGADWDAAVEAWKLLRTDEGAQFDTEVYIDAASLSPFVTWGTNPG 305 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPLS++VPDPE+I DEG R A EKALAYMDLRPGTPMR+I VD VFVGSCTNGRIEDL Sbjct: 306 QGVPLSDSVPDPEMIFDEGERSAVEKALAYMDLRPGTPMREIPVDAVFVGSCTNGRIEDL 365 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVADVLRGR VAD VRML+VPGSMRVRAQAE+EGL +IFTAAGA+WRQAGCSMCLGMNP Sbjct: 366 RVVADVLRGRTVADDVRMLVVPGSMRVRAQAEAEGLGEIFTAAGAEWRQAGCSMCLGMNP 425 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPA 481 DQL+PGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L+SPADL A Sbjct: 426 DQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLTA 477 >sp|A3PXR2|LEUC_MYCSJ Tax_Id=164757 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 869 bits (2245), Expect = 0.0 Identities = 426/471 (90%), Positives = 448/471 (95%) Query: 11 PRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDL 70 PRT+AEKVW DHVVA G GEG A+EPDLIYIDLHLVHEVTSPQAFDGLRLA RPVRRPDL Sbjct: 7 PRTMAEKVWADHVVAHGTGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVRRPDL 66 Query: 71 TIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLG 130 TIATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRLHPMGDAEQGIVHIIGPQLG Sbjct: 67 TIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIGPQLG 126 Query: 131 LTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPP 190 LTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PF+TMAVNVDGELPP Sbjct: 127 LTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDGELPP 186 Query: 191 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPD 250 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAPD Sbjct: 187 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPD 246 Query: 251 ETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQ 310 +TTFEFL+GRPHAP GADWDAAV AW +LRTD GAEFDTEV++DA+ LSPFVTWGTNPGQ Sbjct: 247 DTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGTNPGQ 306 Query: 311 GVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLR 370 GVPLS AVPDPELIVDEG RQAAEKAL YM L+ GT MRD+AVDTVFVGSCTNGRIEDLR Sbjct: 307 GVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRIEDLR 366 Query: 371 VVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPD 430 VVADVLRGR+VADG+RML+VPGSMRVRAQAESEGLD+IF AGA+WRQAGCSMCLGMNPD Sbjct: 367 VVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLGMNPD 426 Query: 431 QLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPA 481 QLSPG+RCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L+SPADL A Sbjct: 427 QLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLSA 477 >sp|Q1BAQ4|LEUC_MYCSS Tax_Id=164756 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 868 bits (2243), Expect = 0.0 Identities = 426/471 (90%), Positives = 448/471 (95%) Query: 11 PRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDL 70 PRT+AEKVW DHVVA G GEG A+EPDLIYIDLHLVHEVTSPQAFDGLRLA RPVRRPDL Sbjct: 7 PRTMAEKVWADHVVAHGIGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVRRPDL 66 Query: 71 TIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLG 130 TIATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRLHPMGDAEQGIVHIIGPQLG Sbjct: 67 TIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIGPQLG 126 Query: 131 LTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPP 190 LTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PF+TMAVNVDGELPP Sbjct: 127 LTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDGELPP 186 Query: 191 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPD 250 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAPD Sbjct: 187 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPD 246 Query: 251 ETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQ 310 +TTFEFL+GRPHAP GADWDAAV AW +LRTD GAEFDTEV++DA+ LSPFVTWGTNPGQ Sbjct: 247 DTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGTNPGQ 306 Query: 311 GVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLR 370 GVPLS AVPDPELIVDEG RQAAEKAL YM L+ GT MRD+AVDTVFVGSCTNGRIEDLR Sbjct: 307 GVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRIEDLR 366 Query: 371 VVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPD 430 VVADVLRGR+VADG+RML+VPGSMRVRAQAESEGLD+IF AGA+WRQAGCSMCLGMNPD Sbjct: 367 VVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLGMNPD 426 Query: 431 QLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPA 481 QLSPG+RCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L+SPADL A Sbjct: 427 QLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLSA 477 >sp|A1UEA8|LEUC_MYCSK Tax_Id=189918 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 868 bits (2243), Expect = 0.0 Identities = 426/471 (90%), Positives = 448/471 (95%) Query: 11 PRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDL 70 PRT+AEKVW DHVVA G GEG A+EPDLIYIDLHLVHEVTSPQAFDGLRLA RPVRRPDL Sbjct: 7 PRTMAEKVWADHVVAHGIGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVRRPDL 66 Query: 71 TIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLG 130 TIATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRLHPMGDAEQGIVHIIGPQLG Sbjct: 67 TIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIGPQLG 126 Query: 131 LTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPP 190 LTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PF+TMAVNVDGELPP Sbjct: 127 LTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDGELPP 186 Query: 191 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPD 250 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAPD Sbjct: 187 GVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPD 246 Query: 251 ETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQ 310 +TTFEFL+GRPHAP GADWDAAV AW +LRTD GAEFDTEV++DA+ LSPFVTWGTNPGQ Sbjct: 247 DTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGTNPGQ 306 Query: 311 GVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLR 370 GVPLS AVPDPELIVDEG RQAAEKAL YM L+ GT MRD+AVDTVFVGSCTNGRIEDLR Sbjct: 307 GVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRIEDLR 366 Query: 371 VVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPD 430 VVADVLRGR+VADG+RML+VPGSMRVRAQAESEGLD+IF AGA+WRQAGCSMCLGMNPD Sbjct: 367 VVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLGMNPD 426 Query: 431 QLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPA 481 QLSPG+RCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L+SPADL A Sbjct: 427 QLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLSA 477 >sp|Q73VI7|LEUC_MYCPA Tax_Id=1770 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium paratuberculosis] Length = 476 Score = 847 bits (2187), Expect = 0.0 Identities = 411/475 (86%), Positives = 445/475 (93%), Gaps = 4/475 (0%) Query: 5 TQTSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRP 64 T T+ PRTLAEKVWDDHVV G A EPDLIYIDLHLVHEVTSPQAFDGLRLAGRP Sbjct: 5 TGTTATPRTLAEKVWDDHVVV----SGGANEPDLIYIDLHLVHEVTSPQAFDGLRLAGRP 60 Query: 65 VRRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHI 124 VRRPDLT+ATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFG+RL+PMGDAEQGIVH+ Sbjct: 61 VRRPDLTLATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHV 120 Query: 125 IGPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNV 184 +GPQLGLTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNV Sbjct: 121 VGPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNV 180 Query: 185 DGELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARA 244 DGELP GV+AKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMT+CNMSIEAGARA Sbjct: 181 DGELPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARA 240 Query: 245 GMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTW 304 GM+APD+TT+EFL+ RPHAPKGA WDAA+ W +LRTD GA FDTEVY+DA++LSPFVTW Sbjct: 241 GMIAPDDTTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEVYLDAASLSPFVTW 300 Query: 305 GTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNG 364 GTNPGQGVPL+ AVPDPEL+ D+ RQAAEKALAYMDLRPGTPMRDIAVD VFVGSCTNG Sbjct: 301 GTNPGQGVPLAAAVPDPELMTDDAERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNG 360 Query: 365 RIEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMC 424 RIEDLRVVADVLRGRKVA GVRML+VPGSMRVRAQAE+EGL ++FTAAGA+WRQAGCSMC Sbjct: 361 RIEDLRVVADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMC 420 Query: 425 LGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 LGMNPDQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L++PADL Sbjct: 421 LGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 475 >sp|A0QJB7|LEUC_MYCA1 Tax_Id=243243 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium avium] Length = 476 Score = 846 bits (2185), Expect = 0.0 Identities = 411/473 (86%), Positives = 444/473 (93%), Gaps = 4/473 (0%) Query: 7 TSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 66 T+ PRTLAEKVWDDHVV G A EPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR Sbjct: 7 TTATPRTLAEKVWDDHVVV----SGGANEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 62 Query: 67 RPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIG 126 RPDLT+ATEDHNVPTIDIDKPIADPVSRTQVETLRRNC EFG+RL+PMGDAEQGIVH++G Sbjct: 63 RPDLTLATEDHNVPTIDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHVVG 122 Query: 127 PQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDG 186 PQLGLTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG Sbjct: 123 PQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG 182 Query: 187 ELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGM 246 ELP GV+AKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMT+CNMSIEAGARAGM Sbjct: 183 ELPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGM 242 Query: 247 VAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGT 306 +APD+TT+EFL+ RPHAPKGA WDAA+ W +LRTD GA FDTEVY+DA++LSPFVTWGT Sbjct: 243 IAPDDTTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEVYLDAASLSPFVTWGT 302 Query: 307 NPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRI 366 NPGQGVPL+ AVPDPEL+ D+ RQAAEKALAYMDLRPGTPMRDIAVD VFVGSCTNGRI Sbjct: 303 NPGQGVPLAAAVPDPELMTDDAERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRI 362 Query: 367 EDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLG 426 EDLRVVADVLRGRKVA GVRML+VPGSMRVRAQAE+EGL ++FTAAGA+WRQAGCSMCLG Sbjct: 363 EDLRVVADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCLG 422 Query: 427 MNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 MNPDQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L++PADL Sbjct: 423 MNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 475 >sp|Q5YRY0|LEUC_NOCFA Tax_Id=37329 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Nocardia farcinica] Length = 474 Score = 840 bits (2171), Expect = 0.0 Identities = 398/470 (84%), Positives = 441/470 (93%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEKVW++HVVARGEGEG ++EPDLIYIDLHLVHEVTSPQAFDGLR AGRPVRRPD Sbjct: 4 RPRTLAEKVWEEHVVARGEGEGASREPDLIYIDLHLVHEVTSPQAFDGLRAAGRPVRRPD 63 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LTIATEDHNVPT+DIDKPIADP+SRTQVETLRRNC EFGIRLHPMGD EQGIVH++GPQL Sbjct: 64 LTIATEDHNVPTVDIDKPIADPISRTQVETLRRNCAEFGIRLHPMGDLEQGIVHVVGPQL 123 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTLSL+PFKTMA+N+DG+LP Sbjct: 124 GLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLSLRPFKTMAINIDGQLP 183 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 PGV++KD+ILAVIA+IGTGGGQG+V+EYRG A+R++SME RMT+CNMSIEAGARAGM+AP Sbjct: 184 PGVTSKDVILAVIAQIGTGGGQGYVLEYRGEAVRAMSMEARMTMCNMSIEAGARAGMIAP 243 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DE T+EFLKGRPHAPKGADWDAAVAAW LRTDEGA FD EV+IDAS+LSPFVTWGTNPG Sbjct: 244 DEVTYEFLKGRPHAPKGADWDAAVAAWDALRTDEGAVFDAEVHIDASSLSPFVTWGTNPG 303 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QG PLS VPDP DE AR+AA KAL YMDL PGTP+R++AVDTVFVGSCTNGRIEDL Sbjct: 304 QGAPLSATVPDPADFADETAREAAAKALRYMDLTPGTPLREVAVDTVFVGSCTNGRIEDL 363 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 R A++L+GR+VA+GVRML+VPGSMRVRAQAE EGL +IFTAAGA+WRQAGCSMCLGMNP Sbjct: 364 RAAAEILKGRRVAEGVRMLVVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGMNP 423 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL PG+RCASTSNRNFEGRQGKGGRTHLVSP VAAATAVRG L+SPADL Sbjct: 424 DQLEPGQRCASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 473 >sp|B1MDQ1|LEUC_MYCA9 Tax_Id=561007 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium abscessus] Length = 480 Score = 832 bits (2148), Expect = 0.0 Identities = 407/479 (84%), Positives = 438/479 (91%), Gaps = 1/479 (0%) Query: 7 TSVK-PRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPV 65 TSV+ PRTLAEKVWD HVV RG GEG A+EPDLIYIDLHLVHEVTSPQAFDGLRLAGR V Sbjct: 2 TSVQQPRTLAEKVWDSHVVVRGTGEGEAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRQV 61 Query: 66 RRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHII 125 RRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLR+NCEEFGIRLHPMGDAEQGIVH++ Sbjct: 62 RRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRKNCEEFGIRLHPMGDAEQGIVHVV 121 Query: 126 GPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVD 185 GPQLGLTQPG TVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PF+TMA+N+D Sbjct: 122 GPQLGLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAINID 181 Query: 186 GELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAG 245 G LP GV++KD+ILAVIAKIGTGGGQG+V+EYRG A+ +SME RMT+CNMSIEAGARAG Sbjct: 182 GSLPTGVTSKDVILAVIAKIGTGGGQGYVLEYRGQAVEEMSMEARMTMCNMSIEAGARAG 241 Query: 246 MVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWG 305 MVAPDETT+ +LK RPHAPKG WDAAVA W LRTDEGA+FD EV+IDASTL+PFVTWG Sbjct: 242 MVAPDETTYAYLKDRPHAPKGQLWDAAVAEWDSLRTDEGAQFDAEVHIDASTLTPFVTWG 301 Query: 306 TNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGR 365 TNPGQGVPL VPDPEL+ DE R AAEKAL YMDL PGTPMR+I VDTVFVGSCTNGR Sbjct: 302 TNPGQGVPLGADVPDPELMADEEERLAAEKALTYMDLTPGTPMREIPVDTVFVGSCTNGR 361 Query: 366 IEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCL 425 IEDLR VADVLR RKVA GV MLIVPGSMRVRAQAESEGL +IF AAGAQWRQAGCSMCL Sbjct: 362 IEDLRAVADVLRDRKVAAGVTMLIVPGSMRVRAQAESEGLGEIFAAAGAQWRQAGCSMCL 421 Query: 426 GMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPAAAR 484 GMNPDQLSPG+RCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKL+SPADL + + Sbjct: 422 GMNPDQLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLSSPADLAKSVK 480 >sp|O33123|LEUC_MYCLE Tax_Id=1769 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium leprae] Length = 476 Score = 827 bits (2137), Expect = 0.0 Identities = 400/470 (85%), Positives = 435/470 (92%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 KPRTLAEKVWDDHVV G+G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRPD Sbjct: 6 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 65 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DIDKPIADPVSR QVETLRRNC EFG+RLHPMGD EQGIVH++GPQL Sbjct: 66 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 125 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGAIAMGIGTSE+EHV+ATQTL L+PFKTMAV VDG LP Sbjct: 126 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 185 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GV+AKDIILA+IAKIGTGGGQG+V+EYRGS I S+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 186 AGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 245 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+EFL+ RPHAP G WDAAVA W +LRTD+ A FDTEVY+DA++LSPFVTWGTNPG Sbjct: 246 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 305 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ +VPDPEL++D+ ARQAAEKALAYMDLRPGTPMRDIAVD VFVGSCTNGRIEDL Sbjct: 306 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 365 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 R+VADVLRG KVADGVRMLIVPGSMRVRAQAE+EGL +IF AGAQWRQ GCSMCLGMNP Sbjct: 366 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 425 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG ++PADL Sbjct: 426 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 475 >tr|B8ZS12|B8ZS12_MYCLB Tax_Id=561304 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Mycobacterium leprae] Length = 485 Score = 827 bits (2137), Expect = 0.0 Identities = 400/470 (85%), Positives = 435/470 (92%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 KPRTLAEKVWDDHVV G+G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRPD Sbjct: 15 KPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPD 74 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DIDKPIADPVSR QVETLRRNC EFG+RLHPMGD EQGIVH++GPQL Sbjct: 75 LTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQL 134 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGAIAMGIGTSE+EHV+ATQTL L+PFKTMAV VDG LP Sbjct: 135 GLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLP 194 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GV+AKDIILA+IAKIGTGGGQG+V+EYRGS I S+SMEGRMTICNMSIEAGARAGMVAP Sbjct: 195 AGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAP 254 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+EFL+ RPHAP G WDAAVA W +LRTD+ A FDTEVY+DA++LSPFVTWGTNPG Sbjct: 255 DETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPG 314 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ +VPDPEL++D+ ARQAAEKALAYMDLRPGTPMRDIAVD VFVGSCTNGRIEDL Sbjct: 315 QGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDL 374 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 R+VADVLRG KVADGVRMLIVPGSMRVRAQAE+EGL +IF AGAQWRQ GCSMCLGMNP Sbjct: 375 RLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNP 434 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG ++PADL Sbjct: 435 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADL 484 >sp|B2HII1|LEUC_MYCMM Tax_Id=216594 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium marinum] Length = 473 Score = 827 bits (2135), Expect = 0.0 Identities = 405/468 (86%), Positives = 430/468 (91%), Gaps = 4/468 (0%) Query: 12 RTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 71 RTLAEKVWDDHVV G E PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT Sbjct: 9 RTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 64 Query: 72 IATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLGL 131 IATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRLHPMGD EQGIVH++GPQLGL Sbjct: 65 IATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGL 124 Query: 132 TQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPPG 191 TQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP G Sbjct: 125 TQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAG 184 Query: 192 VSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDE 251 VSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAPDE Sbjct: 185 VSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDE 244 Query: 252 TTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQG 311 TT+E+L+ RPHAP GA WDAA+ W +LRTD GA FDTEV++DA+ LSPFVTWGTNPGQG Sbjct: 245 TTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQG 304 Query: 312 VPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLRV 371 VPL VPDPELI D+G RQAAEKALAYMDL PG MRDIAVD VFVGSCTNGRIEDLRV Sbjct: 305 VPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRV 364 Query: 372 VADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPDQ 431 VA+VLRGRKVA GVRMLIVPGSMRVRAQAE EGL ++FT AGA+WRQAGCSMCLGMNPDQ Sbjct: 365 VAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQ 424 Query: 432 LSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 L+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L++PADL Sbjct: 425 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 >tr|D5PIY5|D5PIY5_9MYCO Tax_Id=525368 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Mycobacterium parascrofulaceum ATCC BAA-614] Length = 476 Score = 827 bits (2135), Expect = 0.0 Identities = 403/473 (85%), Positives = 439/473 (92%), Gaps = 1/473 (0%) Query: 8 SVKPRTLAEKVWDDHVVARGEGEGT-AKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 66 S KPRTLAEKVWDDHVV G + A PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR Sbjct: 3 SGKPRTLAEKVWDDHVVVSGADDPEQAGAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 62 Query: 67 RPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIG 126 RPDLT+ATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRL+PMG+ EQGIVH++G Sbjct: 63 RPDLTLATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLYPMGNIEQGIVHVVG 122 Query: 127 PQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDG 186 PQLGLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG Sbjct: 123 PQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG 182 Query: 187 ELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGM 246 +LP GV+AKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGM Sbjct: 183 DLPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM 242 Query: 247 VAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGT 306 VAPD TTF+FL+ +PHAP+GA WDAA+ W L TD GA FDTEV++DA++LSPFVTWGT Sbjct: 243 VAPDATTFDFLRDKPHAPQGAQWDAAMRYWQELHTDPGAVFDTEVHLDATSLSPFVTWGT 302 Query: 307 NPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRI 366 NPGQGVPL+ AVPDPEL+ + RQAAEKALAYMDLRPGTPMRDIAVD VFVGSCTNGRI Sbjct: 303 NPGQGVPLAAAVPDPELMTGDDERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRI 362 Query: 367 EDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLG 426 EDLRVVADVLRGRK+A GVRML+VPGSMRVRAQAE+EGL ++FTAAGA+WRQAGCSMCLG Sbjct: 363 EDLRVVADVLRGRKLAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCLG 422 Query: 427 MNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 MNPDQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L++PADL Sbjct: 423 MNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 475 >tr|C1B2N0|C1B2N0_RHOOB Tax_Id=632772 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus opacus] Length = 473 Score = 826 bits (2133), Expect = 0.0 Identities = 399/470 (84%), Positives = 435/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 K RTLAEKVWDDHVV RGEG+ PDLIYIDLHLVHEVTSPQAFDGLRLAGRP+RRPD Sbjct: 7 KARTLAEKVWDDHVVVRGEGDN----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRRPD 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LTIATEDHNVPT+DIDKPIADPVS+TQV+TLRRNCEEFG+RLHPMG+ +QGIVH++GPQL Sbjct: 63 LTIATEDHNVPTVDIDKPIADPVSKTQVDTLRRNCEEFGVRLHPMGNIDQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSL+PF+TMA+ VDGELP Sbjct: 123 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLRPFRTMAITVDGELP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GV++KD+ILAVIAKIGTGGGQG+V+EYRG AIR +SME RMTICNMSIEAGARAGM+AP Sbjct: 183 EGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKMSMEARMTICNMSIEAGARAGMIAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DE T+EF+KGRPHAPKGADWDAAVAAW +L+TDEGA FD EV+IDAS L+PFVTWGTNPG Sbjct: 243 DEITYEFIKGRPHAPKGADWDAAVAAWEQLKTDEGAVFDNEVHIDASALTPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QG+PL EAVPDPE IVDE R AAEKAL YM L GTP+R++A+DTVFVGSCTNGRIEDL Sbjct: 303 QGLPLGEAVPDPEQIVDESERHAAEKALTYMGLEAGTPLREVAIDTVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 R VADVLRGR VADGVRMLIVPGSMRVRAQAE EGL +IFTAAGA+WRQAGCSMCLGMNP Sbjct: 363 RAVADVLRGRHVADGVRMLIVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+PGER ASTSNRNFEGRQGKGGRTHLVSP VAAATAVRG L++P DL Sbjct: 423 DQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPTDL 472 >sp|O53237|LEUC_MYCTU Tax_Id=1773 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium tuberculosis] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >sp|A5U6Z9|LEUC_MYCTA Tax_Id=419947 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium tuberculosis] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|C6DW61|C6DW61_MYCTK Tax_Id=478434 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Mycobacterium tuberculosis] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|A5WRP1|A5WRP1_MYCTF Tax_Id=336982 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Mycobacterium tuberculosis] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D6G1I5|D6G1I5_MYCTU Tax_Id=478435 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis KZN 605] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D6F8C6|D6F8C6_MYCTU Tax_Id=611302 SubName: Full=3-isopropylmalate dehydratase, large subunit;[Mycobacterium tuberculosis T46] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D5ZKI9|D5ZKI9_MYCTU Tax_Id=537210 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis T17] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D5Z7H5|D5Z7H5_MYCTU Tax_Id=537209 SubName: Full=3-isopropylmalate dehydratase (Large subunit) leuC;[Mycobacterium tuberculosis GM 1503] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D5YVS6|D5YVS6_MYCTU Tax_Id=515616 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis 02_1987] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D5YIU9|D5YIU9_MYCTU Tax_Id=520140 SubName: Full=Isopropylmalate isomerase large subunit;[Mycobacterium tuberculosis EAS054] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D5Y783|D5Y783_MYCTU Tax_Id=520141 SubName: Full=Isopropylmalate isomerase large subunit;[Mycobacterium tuberculosis T85] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D5XXZ1|D5XXZ1_MYCTU Tax_Id=515617 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis T92] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|A4KKP4|A4KKP4_MYCTU Tax_Id=395095 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Mycobacterium tuberculosis str. Haarlem] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|A2VLV9|A2VLV9_MYCTU Tax_Id=348776 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Mycobacterium tuberculosis C] Length = 473 Score = 822 bits (2124), Expect = 0.0 Identities = 403/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MRDIAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >sp|A0PPZ6|LEUC_MYCUA Tax_Id=362242 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium ulcerans] Length = 473 Score = 822 bits (2122), Expect = 0.0 Identities = 403/468 (86%), Positives = 429/468 (91%), Gaps = 4/468 (0%) Query: 12 RTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 71 RTLAEKVWDDHVV G E PDLIYIDLH VHEVTSPQAFDGLRLAGRPVRRPDLT Sbjct: 9 RTLAEKVWDDHVVVSGRNEA----PDLIYIDLHQVHEVTSPQAFDGLRLAGRPVRRPDLT 64 Query: 72 IATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLGL 131 IATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRLHPMGD EQGIVH++GPQLGL Sbjct: 65 IATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGL 124 Query: 132 TQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPPG 191 TQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L PFKTMAVNVDG+LP G Sbjct: 125 TQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLWPFKTMAVNVDGQLPAG 184 Query: 192 VSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDE 251 VSAKDIILA+IAKIGTGGGQGHVIEY+GSAI SLSMEGRMTICNMSIEAGARAGMVAPDE Sbjct: 185 VSAKDIILALIAKIGTGGGQGHVIEYQGSAIESLSMEGRMTICNMSIEAGARAGMVAPDE 244 Query: 252 TTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQG 311 TT+E+L+ RPHAP GA WDAA+ W +LRTD GA FDTEV++DA+ LSPFVTWGTNPGQG Sbjct: 245 TTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQG 304 Query: 312 VPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLRV 371 VPL VPDPELI D+G RQAAEKALAYMDL PG MRDIAVD VFVGSCTNGRIEDLRV Sbjct: 305 VPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRV 364 Query: 372 VADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPDQ 431 VA+VLRGRKVA GVRMLIVPGSMRVRAQAE EGL ++FT AGA+WRQAGCSMCLGMNPDQ Sbjct: 365 VAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQ 424 Query: 432 LSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 L+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L++PADL Sbjct: 425 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 >tr|D5PQ46|D5PQ46_COREQ Tax_Id=525370 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus equi ATCC 33707] Length = 477 Score = 822 bits (2122), Expect = 0.0 Identities = 393/468 (83%), Positives = 434/468 (92%) Query: 12 RTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 71 RTLAEKVWD+HVV RGEGEG A++PDLIYIDLHLVHEVTSPQAFDGLRLAGR +RRPDLT Sbjct: 9 RTLAEKVWDEHVVVRGEGEGAARQPDLIYIDLHLVHEVTSPQAFDGLRLAGRKLRRPDLT 68 Query: 72 IATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLGL 131 IATEDHNVPT+DIDKPIADPVSRTQV+TLR+NCEEFG+RLHPMGD +QGIVH++GPQLGL Sbjct: 69 IATEDHNVPTVDIDKPIADPVSRTQVDTLRKNCEEFGVRLHPMGDLDQGIVHVVGPQLGL 128 Query: 132 TQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPPG 191 TQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHVMATQTLSL+PFKTMA+ VDGEL PG Sbjct: 129 TQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFKTMAITVDGELAPG 188 Query: 192 VSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDE 251 V++KD+ILAVIAKIGTGGGQG+V+EYRG AIR LSME RMTICNMSIEAGARAGM+APDE Sbjct: 189 VTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKLSMESRMTICNMSIEAGARAGMIAPDE 248 Query: 252 TTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQG 311 T+EF+KGRPHAP+GADWDAAVAAW +L+TD+ A FD EV+ID S L+PFVTWGTNPGQG Sbjct: 249 ITYEFVKGRPHAPQGADWDAAVAAWDQLKTDDDAVFDAEVHIDGSALTPFVTWGTNPGQG 308 Query: 312 VPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLRV 371 PL ++VPDP DE R AAEKALAYM L GTP+R++ VDTVFVGSCTNGRIEDLR Sbjct: 309 APLGDSVPDPADFADESERLAAEKALAYMGLEAGTPLREVPVDTVFVGSCTNGRIEDLRA 368 Query: 372 VADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPDQ 431 VA+VL+GRKVADGVRML+VPGSMRVRAQAE EGL +IFT AGA+WRQAGCSMCLGMNPDQ Sbjct: 369 VAEVLKGRKVADGVRMLVVPGSMRVRAQAEDEGLGEIFTTAGAEWRQAGCSMCLGMNPDQ 428 Query: 432 LSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 L+PGER ASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKL++PADL Sbjct: 429 LAPGERSASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLSAPADL 476 >sp|C1AGA3|LEUC_MYCBT Tax_Id=561275 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 821 bits (2120), Expect = 0.0 Identities = 402/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MR+IAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >sp|A1KMY2|LEUC_MYCBP Tax_Id=410289 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 821 bits (2120), Expect = 0.0 Identities = 402/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MR+IAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >sp|Q7TXH6|LEUC_MYCBO Tax_Id=1765 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 821 bits (2120), Expect = 0.0 Identities = 402/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MR+IAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|D6FPW2|D6FPW2_MYCTU Tax_Id=611304 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis K85] Length = 473 Score = 821 bits (2120), Expect = 0.0 Identities = 402/470 (85%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MR+IAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|C0ZXN1|C0ZXN1_RHOE4 Tax_Id=234621 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus erythropolis] Length = 473 Score = 819 bits (2116), Expect = 0.0 Identities = 398/470 (84%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 K RTLAEKVWDDHVV +GEG+ +PDLIYIDLHLVHEVTSPQAFDGLRLAGRP+RRPD Sbjct: 7 KARTLAEKVWDDHVVVKGEGQ----DPDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRRPD 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LTIATEDHNVPTIDIDKPIADPVS+TQV+TLRRNCEEFG+RLH MGD +QGIVH++GPQL Sbjct: 63 LTIATEDHNVPTIDIDKPIADPVSKTQVDTLRRNCEEFGVRLHRMGDLDQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPG TVVCGDSHTSTHGAFGA+AMGIGTSEVEHVMATQTLSL+PFKTMA+ VDGELP Sbjct: 123 GLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFKTMAITVDGELP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 PGV++KD+ILAVIAKIGTGGGQG+V+EYRG AIR LSME RMTICNMSIEAGARAGM+AP Sbjct: 183 PGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKLSMEARMTICNMSIEAGARAGMIAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+EF+KGRPHAP GA+WD AVAAW L+TDEGAEFD EV+IDAS L+PFVTWGTNPG Sbjct: 243 DETTYEFIKGRPHAPSGAEWDEAVAAWELLKTDEGAEFDNEVHIDASALTPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QG PL + VPDPELIVDE RQAAEKAL YM L G +RD+AVDTVFVGSCTNGRIEDL Sbjct: 303 QGAPLGDRVPDPELIVDESERQAAEKALTYMGLDAGMALRDVAVDTVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 R VA+VL GR VA+GVRMLIVPGSMRVRAQAESEGL +IFTAAGA+WRQAGCSMCLGMNP Sbjct: 363 RAVAEVLEGRHVAEGVRMLIVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+PGER ASTSNRNFEGRQGKGGRTHLVSP VAAATAVRG L++PADL Sbjct: 423 DQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPADL 472 >tr|D6FKM8|D6FKM8_MYCTU Tax_Id=611303 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis CPHL_A] Length = 473 Score = 819 bits (2115), Expect = 0.0 Identities = 401/470 (85%), Positives = 432/470 (91%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 +PRTLAEK+WDDH+V G G PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP+ Sbjct: 7 EPRTLAEKIWDDHIVVSGGGCA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPE 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LT+ATEDHNVPT+DID+PIADPVSRTQVETLRRNC EFGIRLH MGD EQGIVH++GPQL Sbjct: 63 LTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP Sbjct: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GVSAKDIILA+IAKIGTGGGQGHVIEYRGSAI LSMEGRMTICNMSIEAGARAGMVAP Sbjct: 183 DGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIEPLSMEGRMTICNMSIEAGARAGMVAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+ FL+GRPHAP GA WD A+ W RLRTD GA FDTEVY+DA++LSPFVTWGTNPG Sbjct: 243 DETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QGVPL+ AVPDP+L+ D+ RQAAEKALAYMDLRPGT MR+IAVD VFVGSCTNGRIEDL Sbjct: 303 QGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 RVVA+VLRGRKVADGVRMLIVPGSMRVRAQAE+EGL +IFT AGAQWRQAGCSMCLGMNP Sbjct: 363 RVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+ GERCA+TSNRNFEGRQG GGRTHLVSPAVAAATAVRG L+SPADL Sbjct: 423 DQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADL 472 >tr|Q0S2G4|Q0S2G4_RHOSR Tax_Id=101510 (leuC2)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus sp.] Length = 500 Score = 818 bits (2114), Expect = 0.0 Identities = 394/470 (83%), Positives = 434/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 K RTLAEKVWDDHVV RGEG+ PDLIYIDLHLVHEVTSPQAFDGLRLAGRP+RRPD Sbjct: 34 KARTLAEKVWDDHVVVRGEGDN----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRRPD 89 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LTIATEDHNVPT+DIDKPIADPVS+TQV+TLRRNCEEFG+RLHPMG+ +QGIVH++GPQL Sbjct: 90 LTIATEDHNVPTVDIDKPIADPVSKTQVDTLRRNCEEFGVRLHPMGNIDQGIVHVVGPQL 149 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHVMATQTLSL+PF+TMA+ VDGELP Sbjct: 150 GLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFRTMAITVDGELP 209 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 GV++KD+ILAVIAKIGTGGGQG+V+EYRG AIR +SME RMT+CNMSIEAGARAGM+AP Sbjct: 210 DGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKMSMEARMTVCNMSIEAGARAGMIAP 269 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DE T+EF+KGRPHAPKGADWDAAV AW +L+TDEGA FD EV+IDAS+L+PFVTWGTNPG Sbjct: 270 DEITYEFIKGRPHAPKGADWDAAVEAWEQLKTDEGAVFDNEVHIDASSLTPFVTWGTNPG 329 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QG+PL EAVP+P IVDE R AAEKAL YM L GTP+R++A+DTVFVGSCTNGRIEDL Sbjct: 330 QGLPLGEAVPNPAEIVDESERHAAEKALTYMGLEAGTPLREVAIDTVFVGSCTNGRIEDL 389 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 R VADVLRGR VADGVRMLIVPGSMRVRAQAE EGL +IFTAAGA+WRQAGCSMCLGMNP Sbjct: 390 RAVADVLRGRHVADGVRMLIVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGMNP 449 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+PGER ASTSNRNFEGRQGKGGRTHLVSP VAAATAVRG L++P DL Sbjct: 450 DQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPTDL 499 >tr|C3JSK4|C3JSK4_RHOER Tax_Id=596309 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus erythropolis SK121] Length = 473 Score = 818 bits (2113), Expect = 0.0 Identities = 397/470 (84%), Positives = 433/470 (92%), Gaps = 4/470 (0%) Query: 10 KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 69 K RTLAEKVWDDHVV +GEG+ +PDLIYIDLHLVHEVTSPQAFDGLRLAGR +RRPD Sbjct: 7 KARTLAEKVWDDHVVVKGEGQ----DPDLIYIDLHLVHEVTSPQAFDGLRLAGRQLRRPD 62 Query: 70 LTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQL 129 LTIATEDHNVPTIDIDKPIADPVS+TQV+TLRRNCEEFG+RLH MGD +QGIVH++GPQL Sbjct: 63 LTIATEDHNVPTIDIDKPIADPVSKTQVDTLRRNCEEFGVRLHRMGDLDQGIVHVVGPQL 122 Query: 130 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELP 189 GLTQPG TVVCGDSHTSTHGAFGA+AMGIGTSEVEHVMATQTLSL+PFKTMA+ VDGELP Sbjct: 123 GLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFKTMAITVDGELP 182 Query: 190 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAP 249 PGV++KD+ILAVIAKIGTGGGQG+V+EYRG AIR LSME RMTICNMSIEAGARAGM+AP Sbjct: 183 PGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKLSMEARMTICNMSIEAGARAGMIAP 242 Query: 250 DETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPG 309 DETT+EF+KGRPHAP GA+WD AVAAW L+TDEGAEFD EV+IDAS L+PFVTWGTNPG Sbjct: 243 DETTYEFIKGRPHAPSGAEWDEAVAAWELLKTDEGAEFDNEVHIDASALTPFVTWGTNPG 302 Query: 310 QGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDL 369 QG PL + VPDPELIVDE RQAAEKAL YM L G P+RD++VDTVFVGSCTNGRIEDL Sbjct: 303 QGAPLGDRVPDPELIVDESERQAAEKALTYMGLDAGMPLRDVSVDTVFVGSCTNGRIEDL 362 Query: 370 RVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNP 429 R VA+VL GR VA+GVRMLIVPGSMRVRAQAESEGL +IFTAAGA+WRQAGCSMCLGMNP Sbjct: 363 RAVAEVLEGRHVAEGVRMLIVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNP 422 Query: 430 DQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 DQL+PGER ASTSNRNFEGRQGKGGRTHLVSP VAAATAVRG L++PADL Sbjct: 423 DQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPADL 472 >tr|C7MXF5|C7MXF5_SACVD Tax_Id=471857 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Saccharomonospora viridis] Length = 471 Score = 800 bits (2067), Expect = 0.0 Identities = 392/473 (82%), Positives = 426/473 (90%), Gaps = 4/473 (0%) Query: 7 TSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 66 T + RTLAEKVWD HVV RGEG EPDL+YIDLHLVHEVTSPQAFDGLRLAGR VR Sbjct: 2 TEKRGRTLAEKVWDAHVVRRGEGA----EPDLLYIDLHLVHEVTSPQAFDGLRLAGRKVR 57 Query: 67 RPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIG 126 RPDLTIATEDHNVPT ID PIADPVSRTQVETLRRNCEEFGIRLHPMGD EQGIVH+IG Sbjct: 58 RPDLTIATEDHNVPTTGIDLPIADPVSRTQVETLRRNCEEFGIRLHPMGDDEQGIVHVIG 117 Query: 127 PQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDG 186 PQLGLTQPGMTVVCGDSHTSTHGAFGA+A GIGTSEVEHV+ATQTL ++PFKTMAVNVDG Sbjct: 118 PQLGLTQPGMTVVCGDSHTSTHGAFGAMAFGIGTSEVEHVLATQTLPMRPFKTMAVNVDG 177 Query: 187 ELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGM 246 +L PGV+AKDIILAVIAKIGTGGGQGHVIEYRGS I +LSME RMTICNMSIEAGARAGM Sbjct: 178 QLRPGVTAKDIILAVIAKIGTGGGQGHVIEYRGSTIEALSMEARMTICNMSIEAGARAGM 237 Query: 247 VAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGT 306 +APDETTF +LK RPHAP+GADWDAA+A W LRTD+ A FDTEV++DAS L+PFVTWGT Sbjct: 238 IAPDETTFAYLKDRPHAPQGADWDAALAEWRELRTDDDAVFDTEVHLDASELTPFVTWGT 297 Query: 307 NPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRI 366 NPGQG+PLSE+VPDPE + DE R AAEKAL+YMDL+PGTP+R+IAVDTVF+GSCTNGR+ Sbjct: 298 NPGQGLPLSESVPDPEQMTDETERLAAEKALSYMDLKPGTPLREIAVDTVFLGSCTNGRL 357 Query: 367 EDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLG 426 EDLR A+VL+GRKVADGVRML+VPGSMRVR AE EGL ++FT AGA+WR AGCSMCLG Sbjct: 358 EDLRAAAEVLKGRKVADGVRMLVVPGSMRVRKAAEEEGLHEVFTEAGAEWRAAGCSMCLG 417 Query: 427 MNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 MNPDQL PGER ASTSNRNFEGRQGKGGRTHLVSP VAAATAVRG L+SP DL Sbjct: 418 MNPDQLKPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPEDL 470 >tr|D0LC33|D0LC33_GORB4 Tax_Id=526226 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Gordonia bronchialis] Length = 477 Score = 799 bits (2063), Expect = 0.0 Identities = 390/476 (81%), Positives = 426/476 (89%), Gaps = 1/476 (0%) Query: 5 TQTSVKPRTLAEKVWDDHVVARGEGEGT-AKEPDLIYIDLHLVHEVTSPQAFDGLRLAGR 63 + ++ KPRTLAEKVW+DHVV GE + + A+ PDLIYIDLHLVHEVTSPQAF+GLRLAGR Sbjct: 2 SNSTAKPRTLAEKVWEDHVVVPGEADASGAQNPDLIYIDLHLVHEVTSPQAFEGLRLAGR 61 Query: 64 PVRRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVH 123 PVRRPDLTIATEDHNVPT+DI PIAD VSRTQVETLRRNC EFGIRLHPMGDAEQGIVH Sbjct: 62 PVRRPDLTIATEDHNVPTLDIFSPIADEVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVH 121 Query: 124 IIGPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVN 183 ++GPQLGLTQPGMTVVCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTLSL+PFKTMA+ Sbjct: 122 VVGPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLSLRPFKTMAIT 181 Query: 184 VDGELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGAR 243 VDGELP GV++KD+ILAVIAKIGTGGGQG+V+EYRG AI LSME RMTICNMSIEAGAR Sbjct: 182 VDGELPSGVTSKDLILAVIAKIGTGGGQGYVLEYRGPAIEKLSMEARMTICNMSIEAGAR 241 Query: 244 AGMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVT 303 AGM+APD+ T++FLKGRP+AP GADWDAAV W LRTD GAEFD EV+IDAS L+PFVT Sbjct: 242 AGMIAPDQVTYDFLKGRPNAPTGADWDAAVQYWDSLRTDPGAEFDAEVHIDASALTPFVT 301 Query: 304 WGTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTN 363 WGTNPGQG PL VPDP + DE A AA KAL YMDL PG P+RDI VDTVFVGSCTN Sbjct: 302 WGTNPGQGAPLGAVVPDPADMGDENASTAASKALEYMDLTPGMPLRDIKVDTVFVGSCTN 361 Query: 364 GRIEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSM 423 GRIEDLR VA++L+GRKVA+G+RMLIVPGSMRVRAQAE EGL IF AGA+WRQAGCSM Sbjct: 362 GRIEDLRAVAEILKGRKVAEGMRMLIVPGSMRVRAQAEDEGLGDIFEHAGAEWRQAGCSM 421 Query: 424 CLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 CLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L+SP DL Sbjct: 422 CLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPDDL 477 >tr|D3LP98|D3LP98_MICLU Tax_Id=596312 (leuC)SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Micrococcus luteus SK58] Length = 559 Score = 796 bits (2055), Expect = 0.0 Identities = 382/479 (79%), Positives = 426/479 (88%) Query: 3 QPTQTSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAG 62 Q T + +PRTLAEKVWD+HVV RGEGEG+++ PDL+YIDLHLVHEVTSPQAF+GLRLAG Sbjct: 75 QMTTATTRPRTLAEKVWDEHVVVRGEGEGSSRTPDLLYIDLHLVHEVTSPQAFEGLRLAG 134 Query: 63 RPVRRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIV 122 RPVRRPDLTIATEDHN PT+DID+PIADP SRTQ+ETLR NC EFG+RLHP+GDAEQGIV Sbjct: 135 RPVRRPDLTIATEDHNTPTLDIDQPIADPTSRTQIETLRANCAEFGVRLHPLGDAEQGIV 194 Query: 123 HIIGPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAV 182 H++GPQLGLTQPG+TVVCGDSHTSTHGAFGA+A GIGTSEVEHV+ATQTL LKPFKTMAV Sbjct: 195 HVVGPQLGLTQPGLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLKPFKTMAV 254 Query: 183 NVDGELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGA 242 VDG L PGV+AKDIILAVIAKIGTGGGQG V+EYRG AIR+LSMEGRMTICNMSIEAGA Sbjct: 255 TVDGALRPGVTAKDIILAVIAKIGTGGGQGFVLEYRGEAIRNLSMEGRMTICNMSIEAGA 314 Query: 243 RAGMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFV 302 RAGMVAPDETTF +LKGRPHAP+GADWDAAV W L TDEGAEFD EV IDA TL PFV Sbjct: 315 RAGMVAPDETTFAYLKGRPHAPEGADWDAAVEHWRTLATDEGAEFDAEVVIDADTLEPFV 374 Query: 303 TWGTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCT 362 TWGTNPGQGV L++ VP PE D A++AA KAL+YMDL PGTPM+ + VDTVF+GSCT Sbjct: 375 TWGTNPGQGVSLNDTVPAPEDFADPVAQEAARKALSYMDLAPGTPMKQVEVDTVFMGSCT 434 Query: 363 NGRIEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCS 422 N RIEDLR A+V+RGR+ A+G+R+++VPGS RVR QA EGLD++F GA+WR AGCS Sbjct: 435 NSRIEDLRAFAEVVRGRRKAEGLRVMVVPGSARVRLQAMDEGLDRVFEDFGAEWRFAGCS 494 Query: 423 MCLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPA 481 MCLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSP VAAATAV G+LASP+DLPA Sbjct: 495 MCLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPVVAAATAVLGRLASPSDLPA 553 >tr|C6WG49|C6WG49_ACTMD Tax_Id=446462 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Actinosynnema mirum] Length = 472 Score = 791 bits (2043), Expect = 0.0 Identities = 384/471 (81%), Positives = 421/471 (89%), Gaps = 4/471 (0%) Query: 12 RTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 71 RTLAEKVW+ HVV G G EPDL+YIDLHL+HEVTSPQAFDGLRLAGR +RRPDLT Sbjct: 3 RTLAEKVWEAHVVRHGSGA----EPDLLYIDLHLLHEVTSPQAFDGLRLAGRRLRRPDLT 58 Query: 72 IATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLGL 131 IATEDHNVPT+DI+ PIADPVSRTQVETLRRNC EFG+RLHPMGDAEQGIVH++GPQLGL Sbjct: 59 IATEDHNVPTVDIELPIADPVSRTQVETLRRNCAEFGVRLHPMGDAEQGIVHVVGPQLGL 118 Query: 132 TQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPPG 191 TQPGMTVVCGDSHTSTHGAFGA+A GIGTSEVEHVMATQTL L+PFKTMA+NV+G L PG Sbjct: 119 TQPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQTLPLRPFKTMAINVEGSLRPG 178 Query: 192 VSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDE 251 V+AKD+ILAVIAKIGTGGGQG+V+EYRGSAI +LSME RMT+CNMSIEAGARAGM+APD+ Sbjct: 179 VTAKDVILAVIAKIGTGGGQGYVLEYRGSAISALSMEARMTVCNMSIEAGARAGMIAPDQ 238 Query: 252 TTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQG 311 TTF+++KGRPHAP GADWDAAV WS L TDEGAEFD EV +DA L+PFVTWGTNPGQG Sbjct: 239 TTFDYIKGRPHAPSGADWDAAVEYWSTLATDEGAEFDAEVTLDADELTPFVTWGTNPGQG 298 Query: 312 VPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLRV 371 +PL +VPDPE I DE R AAEKAL+YM L GTP+RDI VDTVF+GSCTNGRIEDLR Sbjct: 299 LPLGASVPDPEAIADENERVAAEKALSYMGLEAGTPLRDIRVDTVFLGSCTNGRIEDLRA 358 Query: 372 VADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPDQ 431 ADVLRG VADGVRML+VPGSMRVRAQAE+EGL ++F AAGA+WRQAGCSMCLGMNPDQ Sbjct: 359 AADVLRGHHVADGVRMLVVPGSMRVRAQAETEGLHEVFQAAGAEWRQAGCSMCLGMNPDQ 418 Query: 432 LSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPAA 482 L PGER ASTSNRNFEGRQGKGGRTHLVSP VAAATAVRG L+SPADL A Sbjct: 419 LKPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADLTPA 469 >tr|C5CAC8|C5CAC8_MICLC Tax_Id=465515 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Micrococcus luteus] Length = 484 Score = 790 bits (2041), Expect = 0.0 Identities = 380/477 (79%), Positives = 423/477 (88%) Query: 5 TQTSVKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRP 64 T + +PRTLAEKVWD+HVV RGEGEG ++ PDL+YIDLHLVHEVTSPQAF+GLRLAGRP Sbjct: 2 TTATTRPRTLAEKVWDEHVVVRGEGEGASRTPDLLYIDLHLVHEVTSPQAFEGLRLAGRP 61 Query: 65 VRRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHI 124 VRRPDLTIATEDHN PT+DID+PIAD SRTQ+ETLR NC EFG+RLHP+GDAEQGIVH+ Sbjct: 62 VRRPDLTIATEDHNTPTLDIDQPIADATSRTQIETLRANCAEFGVRLHPLGDAEQGIVHV 121 Query: 125 IGPQLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNV 184 +GPQLGLTQPG+TVVCGDSHTSTHGAFGA+A GIGTSEVEHV+ATQTL LKPFKTMAV V Sbjct: 122 VGPQLGLTQPGLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLKPFKTMAVTV 181 Query: 185 DGELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARA 244 DG L PGV+AKDIILAVIAKIGTGGGQG V+EYRG AIR+LSMEGRMTICNMSIEAGARA Sbjct: 182 DGTLRPGVTAKDIILAVIAKIGTGGGQGFVLEYRGEAIRNLSMEGRMTICNMSIEAGARA 241 Query: 245 GMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTW 304 GMVAPDETTF +LKGRPHAP GADWDAAV W L TDEGAEFD EV IDA TL PFVTW Sbjct: 242 GMVAPDETTFAYLKGRPHAPVGADWDAAVEHWRTLATDEGAEFDAEVVIDADTLEPFVTW 301 Query: 305 GTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNG 364 GTNPGQGV L++AVP PE D A++AA KAL+YMDL PGTPM+ + VDTVF+GSCTN Sbjct: 302 GTNPGQGVSLNDAVPAPEDFADPVAQEAARKALSYMDLAPGTPMKQVEVDTVFMGSCTNS 361 Query: 365 RIEDLRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMC 424 RIEDLR A+V+RGR+ A+G+R+++VPGS RVR QA EGLD++F GA+WR AGCSMC Sbjct: 362 RIEDLRAFAEVVRGRRKAEGLRVMVVPGSARVRLQAMDEGLDRVFEDFGAEWRFAGCSMC 421 Query: 425 LGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPA 481 LGMNPDQL+PGERCASTSNRNFEGRQGKGGRTHLVSP VAAATAV G+LASP+DLPA Sbjct: 422 LGMNPDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPVVAAATAVLGRLASPSDLPA 478 >tr|D5UTG1|D5UTG1_TSUPA Tax_Id=521096 SubName: Full=3-isopropylmalate dehydratase, large subunit;[Tsukamurella paurometabola DSM 20162] Length = 481 Score = 788 bits (2034), Expect = 0.0 Identities = 381/474 (80%), Positives = 423/474 (89%) Query: 9 VKPRTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRP 68 ++PRT+AEKVWD HVV +GEGEG ++EPDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP Sbjct: 1 MQPRTMAEKVWDQHVVVKGEGEGASREPDLIYIDLHLVHEVTSPQAFDGLRLAGRTVRRP 60 Query: 69 DLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQ 128 DLTIATEDHNVPT + +PIAD VSRTQVETLRRNC EFG+RLH MGD EQGIVH++GPQ Sbjct: 61 DLTIATEDHNVPTDTLVQPIADEVSRTQVETLRRNCAEFGVRLHSMGDGEQGIVHVMGPQ 120 Query: 129 LGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGEL 188 LGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHV+ATQTL+LKPFKTMA+NV GEL Sbjct: 121 LGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVLATQTLALKPFKTMAINVSGEL 180 Query: 189 PPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVA 248 PGV++KD+ILA+IAKIGTGGGQG+V+EYRGSAI LSME RMTICNMSIEAGARAGM+A Sbjct: 181 QPGVTSKDLILAIIAKIGTGGGQGYVLEYRGSAIEKLSMEARMTICNMSIEAGARAGMIA 240 Query: 249 PDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNP 308 PD+ T+++++GR HAP+G WD AVAAW LRTDEGA FD E+ ID L+PFVTWGTNP Sbjct: 241 PDQITYDYIRGREHAPQGELWDEAVAAWDALRTDEGAVFDAEIDIDGGALTPFVTWGTNP 300 Query: 309 GQGVPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIED 368 GQG+PLS +VPDP +G R+ A KAL YM L PGTP+R+IAVDTVFVGSCTNGRIED Sbjct: 301 GQGLPLSGSVPDPASFGSDGERETAAKALQYMGLEPGTPLREIAVDTVFVGSCTNGRIED 360 Query: 369 LRVVADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMN 428 LR VA++LRGRKVADGVRML+VPGSMRVRAQAE EGL QIF AGA+WRQAGCSMCLGMN Sbjct: 361 LRAVAEILRGRKVADGVRMLVVPGSMRVRAQAEEEGLGQIFLDAGAEWRQAGCSMCLGMN 420 Query: 429 PDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPAA 482 PDQL+PGER ASTSNRNFEGRQGKG RTHLVSPAVAAATAVRG L+SPADL A Sbjct: 421 PDQLAPGERSASTSNRNFEGRQGKGSRTHLVSPAVAAATAVRGTLSSPADLAPA 474 Database: Amellifera_nr Posted date: Jul 23, 2010 5:10 AM Number of letters in database: 4,236,830,644 Number of sequences in database: 12,507,864 Lambda K H 0.317 0.134 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 12507864 Number of Hits to DB: 4,167,595,610 Number of extensions: 183010342 Number of successful extensions: 433578 Number of sequences better than 10.0: 5388 Number of HSP's gapped: 426010 Number of HSP's successfully gapped: 6204 Length of query: 484 Length of database: 4,236,830,644 Length adjustment: 142 Effective length of query: 342 Effective length of database: 2,460,713,956 Effective search space: 841564172952 Effective search space used: 841564172952 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 83 (36.6 bits)