BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MSMEG_4229 (493 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 12,507,864 sequences; 4,236,830,644 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|A0R018|MURD_MYCS2 Tax_Id=246196 (murD)RecName: Full=UDP-N-ace... 762 0.0 tr|Q1B6W9|Q1B6W9_MYCSS Tax_Id=164756 (murD)RecName: Full=UDP-N-a... 547 e-153 tr|A1UI56|A1UI56_MYCSK Tax_Id=189918 (murD)RecName: Full=UDP-N-a... 547 e-153 tr|A3Q1M0|A3Q1M0_MYCSJ Tax_Id=164757 (murD)RecName: Full=UDP-N-a... 546 e-153 sp|A1TAX0|MURD_MYCVP Tax_Id=350058 (murD)RecName: Full=UDP-N-ace... 527 e-147 tr|D5P6X1|D5P6X1_9MYCO Tax_Id=525368 (murD)SubName: Full=UDP-N-a... 524 e-146 sp|A0QF50|MURD_MYCA1 Tax_Id=243243 (murD)RecName: Full=UDP-N-ace... 522 e-146 tr|A4TBF3|A4TBF3_MYCGI Tax_Id=350054 (murD)RecName: Full=UDP-N-a... 519 e-145 sp|Q73YQ6|MURD_MYCPA Tax_Id=1770 (murD)RecName: Full=UDP-N-acety... 516 e-144 tr|B2HGR8|B2HGR8_MYCMM Tax_Id=216594 (murD)SubName: Full=UDP-N-a... 503 e-140 tr|A0PTI9|A0PTI9_MYCUA Tax_Id=362242 (murD)SubName: Full=UDP-N-a... 499 e-139 tr|C6DPQ3|C6DPQ3_MYCTK Tax_Id=478434 (murD)RecName: Full=UDP-N-a... 491 e-136 tr|D6G6J2|D6G6J2_MYCTU Tax_Id=478435 SubName: Full=UDP-N-acetylm... 491 e-136 tr|A4KIT3|A4KIT3_MYCTU Tax_Id=395095 (murD)RecName: Full=UDP-N-a... 489 e-136 tr|A2VJQ2|A2VJQ2_MYCTU Tax_Id=348776 (murD)RecName: Full=UDP-N-a... 489 e-136 sp|C1AQ71|MURD_MYCBT Tax_Id=561275 (murD)RecName: Full=UDP-N-ace... 488 e-135 sp|A1KKJ8|MURD_MYCBP Tax_Id=410289 (murD)RecName: Full=UDP-N-ace... 488 e-135 sp|Q7VEP7|MURD_MYCBO Tax_Id=1765 (murD)RecName: Full=UDP-N-acety... 488 e-135 tr|A5WPC7|A5WPC7_MYCTF Tax_Id=336982 (murD)RecName: Full=UDP-N-a... 488 e-135 tr|D6FWH3|D6FWH3_MYCTU Tax_Id=611304 SubName: Full=UDP-N-acetylM... 488 e-135 tr|D6F5T4|D6F5T4_MYCTU Tax_Id=611302 SubName: Full=UDP-N-acetylM... 488 e-135 tr|D5YGY6|D5YGY6_MYCTU Tax_Id=520140 SubName: Full=UDP-N-acetylm... 488 e-135 tr|D5Y4Z6|D5Y4Z6_MYCTU Tax_Id=520141 SubName: Full=UDP-N-acetylm... 488 e-135 sp|O06222|MURD_MYCTU Tax_Id=1773 (murD)RecName: Full=UDP-N-acety... 484 e-135 sp|A5U4I2|MURD_MYCTA Tax_Id=419947 (murD)RecName: Full=UDP-N-ace... 484 e-135 sp|P57995|MURD_MYCLE Tax_Id=1769 (murD)RecName: Full=UDP-N-acety... 478 e-132 sp|B8ZQP8|MURD_MYCLB Tax_Id=561304 (murD)RecName: Full=UDP-N-ace... 478 e-132 tr|B1MP35|B1MP35_MYCA9 Tax_Id=561007 (murD)RecName: Full=UDP-N-a... 462 e-128 tr|D6FI51|D6FI51_MYCTU Tax_Id=611303 SubName: Full=UDP-N-acetylM... 458 e-127 tr|D5XUS2|D5XUS2_MYCTU Tax_Id=515617 SubName: Full=UDP-N-acetylm... 448 e-124 tr|C1AU57|C1AU57_RHOOB Tax_Id=632772 (murD)SubName: Full=UDP-N-a... 403 e-110 sp|Q0SHR9|MURD_RHOSR Tax_Id=101510 (murD)RecName: Full=UDP-N-ace... 401 e-109 tr|C3JJ50|C3JJ50_RHOER Tax_Id=596309 (murD)SubName: Full=UDP-N-a... 400 e-109 tr|D5PP41|D5PP41_COREQ Tax_Id=525370 (murD)SubName: Full=UDP-N-a... 400 e-109 tr|C1A0X7|C1A0X7_RHOE4 Tax_Id=234621 (murD)SubName: Full=UDP-N-a... 399 e-109 tr|D5USH7|D5USH7_TSUPA Tax_Id=521096 SubName: Full=UDP-N-acetylm... 374 e-101 tr|D5ZG53|D5ZG53_MYCTU Tax_Id=537210 SubName: Full=UDP-N-acetylm... 374 e-101 sp|Q5YYY1|MURD_NOCFA Tax_Id=37329 (murD)RecName: Full=UDP-N-acet... 363 3e-98 tr|D0LAT4|D0LAT4_GORB4 Tax_Id=526226 (murD)RecName: Full=UDP-N-a... 346 5e-93 tr|C6WDE4|C6WDE4_ACTMD Tax_Id=446462 SubName: Full=UDP-N-acetylm... 321 2e-85 tr|D5YRL3|D5YRL3_MYCTU Tax_Id=515616 SubName: Full=UDP-N-acetylm... 306 4e-81 tr|C8XGY8|C8XGY8_NAKMY Tax_Id=479431 SubName: Full=UDP-N-acetylm... 305 7e-81 tr|A4QFM5|A4QFM5_CORGB Tax_Id=340322 (murD)RecName: Full=UDP-N-a... 305 1e-80 tr|Q6M3S0|Q6M3S0_CORGL Tax_Id=1718 (murD)SubName: Full=UDP-N-ACE... 301 1e-79 tr|A4FLW2|A4FLW2_SACEN Tax_Id=405948 (murD)SubName: Full=UDP-N-a... 301 1e-79 >sp|A0R018|MURD_MYCS2 Tax_Id=246196 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium smegmatis] Length = 493 Score = 762 bits (1968), Expect = 0.0 Identities = 402/482 (83%), Positives = 402/482 (83%) Query: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAV 60 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEV KGVAV Sbjct: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVAATLCDDNADALAALAAKGVAV 60 Query: 61 IAPGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRR 120 IAPGDAIASIGDYALVVTSPGF GVPIWGDVELAWRLDAAGRYGPPRR Sbjct: 61 IAPGDAIASIGDYALVVTSPGFAPSAPVLAAAAAAGVPIWGDVELAWRLDAAGRYGPPRR 120 Query: 121 WLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 WLVV SMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW Sbjct: 121 WLVVTGTNGKTTTTSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT Sbjct: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPI Sbjct: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIGVLDALGAAALARAV 300 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 SFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG Sbjct: 301 GVAPGAIGAALASFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE Sbjct: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 SIESVGDHVTRVIEVGGRP RDLASPGDTVLLAPAGASFDQFSGYGQR Sbjct: 421 SIESVGDHVTRVIEVGGRPVSDAVMSAVVSAARDLASPGDTVLLAPAGASFDQFSGYGQR 480 Query: 481 GD 482 GD Sbjct: 481 GD 482 >tr|Q1B6W9|Q1B6W9_MYCSS Tax_Id=164756 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 547 bits (1410), Expect = e-153 Identities = 300/481 (62%), Positives = 328/481 (68%), Gaps = 12/481 (2%) Query: 10 PLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIAS 69 PLTPG RVL+TGAG+TGR+V L P V AV+ G+A+A Sbjct: 8 PLTPGVRVLITGAGLTGRSVSAVLEPTGVRLTICDDDPLALQRLITPA-AVVTTGEAVAG 66 Query: 70 IGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXX 129 I DYALVVTSPGF GVPIWGDVELAWRLD AG +GPPRRWLVV Sbjct: 67 IADYALVVTSPGFPPTAPVLAAAAAAGVPIWGDVELAWRLDRAGWFGPPRRWLVVTGTNG 126 Query: 130 XXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVL--------DQPAELLAVELSSFQLHWA 181 SML+ +L A RR++LCGNIG+PVL VL D+ ELLAVELSSFQLHWA Sbjct: 127 KTTTTSMLYAILRAADRRAMLCGNIGNPVLDVLGESPRTRGDEEPELLAVELSSFQLHWA 186 Query: 182 PSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATV 241 PSLRP+AGVVLNVAEDHLDWHGSM AYARDKAR LDGRVAV GLDDPVAA LL TAAA V Sbjct: 187 PSLRPDAGVVLNVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVAAELLTTAAAPV 246 Query: 242 RVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXX 301 RVGFRLG P AGELGV DG L+D AF DG+ LA DI VAGP+ Sbjct: 247 RVGFRLGPPGAGELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNALAAAALARAVD 306 Query: 302 XXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGL 361 SF+VGRHRAEVV GV ++DDSKATNPHAA+ASI AY RVVW+AGGL Sbjct: 307 VPAEAVAAALASFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAAYPRVVWIAGGL 366 Query: 362 LKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNES 421 LKG SVD LV +VA+RLAG VLIGRDR +VA+ALSRHAPDVPVVELV GEDSGV GT Sbjct: 367 LKGVSVDALVAEVADRLAGVVLIGRDRAVVAEALSRHAPDVPVVELVTGEDSGVHGTT-- 424 Query: 422 IESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 ES +HVTRVI+ GGRP R LA PGD VLLAPAGASFDQFSGY QRG Sbjct: 425 -ESAVNHVTRVIDTGGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQFSGYTQRG 483 Query: 482 D 482 D Sbjct: 484 D 484 >tr|A1UI56|A1UI56_MYCSK Tax_Id=189918 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 547 bits (1410), Expect = e-153 Identities = 300/481 (62%), Positives = 328/481 (68%), Gaps = 12/481 (2%) Query: 10 PLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIAS 69 PLTPG RVL+TGAG+TGR+V L P V AV+ G+A+A Sbjct: 8 PLTPGVRVLITGAGLTGRSVSAVLEPTGVRLTICDDDPLALQRLITPA-AVVTTGEAVAG 66 Query: 70 IGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXX 129 I DYALVVTSPGF GVPIWGDVELAWRLD AG +GPPRRWLVV Sbjct: 67 IADYALVVTSPGFPPTAPVLAAAAAAGVPIWGDVELAWRLDRAGWFGPPRRWLVVTGTNG 126 Query: 130 XXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVL--------DQPAELLAVELSSFQLHWA 181 SML+ +L A RR++LCGNIG+PVL VL D+ ELLAVELSSFQLHWA Sbjct: 127 KTTTTSMLYAILRAADRRAMLCGNIGNPVLDVLGESPRTRGDEEPELLAVELSSFQLHWA 186 Query: 182 PSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATV 241 PSLRP+AGVVLNVAEDHLDWHGSM AYARDKAR LDGRVAV GLDDPVAA LL TAAA V Sbjct: 187 PSLRPDAGVVLNVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVAAELLTTAAAPV 246 Query: 242 RVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXX 301 RVGFRLG P AGELGV DG L+D AF DG+ LA DI VAGP+ Sbjct: 247 RVGFRLGPPGAGELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNALAAAALARAVD 306 Query: 302 XXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGL 361 SF+VGRHRAEVV GV ++DDSKATNPHAA+ASI AY RVVW+AGGL Sbjct: 307 VPAEAVAAALASFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAAYPRVVWIAGGL 366 Query: 362 LKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNES 421 LKG SVD LV +VA+RLAG VLIGRDR +VA+ALSRHAPDVPVVELV GEDSGV GT Sbjct: 367 LKGVSVDALVAEVADRLAGVVLIGRDRAVVAEALSRHAPDVPVVELVTGEDSGVHGTT-- 424 Query: 422 IESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 ES +HVTRVI+ GGRP R LA PGD VLLAPAGASFDQFSGY QRG Sbjct: 425 -ESAVNHVTRVIDTGGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQFSGYTQRG 483 Query: 482 D 482 D Sbjct: 484 D 484 >tr|A3Q1M0|A3Q1M0_MYCSJ Tax_Id=164757 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 546 bits (1407), Expect = e-153 Identities = 300/481 (62%), Positives = 327/481 (67%), Gaps = 12/481 (2%) Query: 10 PLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIAS 69 PLTPGARVL+TGAG+TGR+V L P V AV+ G+A+A Sbjct: 8 PLTPGARVLITGAGLTGRSVSAVLEPTGVRLTICDDDPLALQRLITPA-AVVTTGEAVAG 66 Query: 70 IGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXX 129 I DYALVVTSPGF GVPIWGDVELAWRLD AG +GPPRRWLVV Sbjct: 67 IADYALVVTSPGFPPTAPVLSAAAAAGVPIWGDVELAWRLDRAGWFGPPRRWLVVTGTNG 126 Query: 130 XXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVL--------DQPAELLAVELSSFQLHWA 181 SML+ +L A RR +LCGNIG+PVL VL D+ ELLAVELSSFQLHWA Sbjct: 127 KTTTTSMLYAILRAADRRVMLCGNIGNPVLDVLGESPRTRGDEEPELLAVELSSFQLHWA 186 Query: 182 PSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATV 241 PSLRP+AGVVLNVAEDHLDWHGSM AYARDKAR LDGRVAV GLDDPVAA LL TAAA V Sbjct: 187 PSLRPDAGVVLNVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVAAELLTTAAAPV 246 Query: 242 RVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXX 301 RVGFRLG P AGELGV DG L+D AF DG+ LA DI VAGP+ Sbjct: 247 RVGFRLGPPGAGELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNALAAAALARAVD 306 Query: 302 XXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGL 361 SF+VGRHRAEVV GV ++DDSKATNPHAA+ASI AY RVVW+AGGL Sbjct: 307 VPAEAVAAALASFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAAYPRVVWIAGGL 366 Query: 362 LKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNES 421 LKG SVD LV +VA+RL G VLIGRDR +VA+ALSRHAPDVPVVELV GEDSGV GT Sbjct: 367 LKGVSVDALVAEVADRLTGVVLIGRDRAVVAEALSRHAPDVPVVELVTGEDSGVHGTT-- 424 Query: 422 IESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 ES +HVTRVI+ GGRP R LA PGD VLLAPAGASFDQFSGY QRG Sbjct: 425 -ESAVNHVTRVIDTGGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQFSGYTQRG 483 Query: 482 D 482 D Sbjct: 484 D 484 >sp|A1TAX0|MURD_MYCVP Tax_Id=350058 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium vanbaalenii] Length = 483 Score = 527 bits (1357), Expect = e-147 Identities = 283/475 (59%), Positives = 319/475 (67%), Gaps = 3/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 + P++PGA VLV GAGITGRAVL ALAPL + V V+ P A+ Sbjct: 1 MQPISPGAAVLVVGAGITGRAVLAALAPLGARATLTDDSPTALTASAQQRVEVLDPATAV 60 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I D+ LVV SPG G+P+WGDVELAW LD +GR+GPPR+WLVV Sbjct: 61 DRIADFDLVVVSPGIPPTAPIPVAAAAAGIPVWGDVELAWHLDRSGRFGPPRQWLVVTGT 120 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SML+ ML AGGRR+VLCGNIGDPVL+ LD+PA++LAVELSSFQLHWAPSLRPE Sbjct: 121 NGKTTTTSMLYAMLQAGGRRAVLCGNIGDPVLSQLDRPADVLAVELSSFQLHWAPSLRPE 180 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLNVAEDHLDWHGSMAAYA DKAR L GRVAV GLDD +AAGLL A A V+VGFRL Sbjct: 181 AGAVLNVAEDHLDWHGSMAAYAGDKARALTGRVAVGGLDDAIAAGLLADAPAPVKVGFRL 240 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 GDP GE GVRDG LID AF + LAD I VAGP+ Sbjct: 241 GDPGPGEFGVRDGVLIDNAFGRDLALADADTIPVAGPVGVLDALAAAALARAVDVPAAAI 300 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 +F VGRHRAEVV DG+ ++DDSKATNPHAAQAS++A+ RVVWVAGGLLKGASV Sbjct: 301 AEALATFHVGRHRAEVVAVADGITYVDDSKATNPHAAQASVSAFPRVVWVAGGLLKGASV 360 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 DE+V +RL G VLIGRDR +V +ALSRHAPDVPVVELV GEDS VL E ES Sbjct: 361 DEMVEATKDRLVGVVLIGRDRAIVGNALSRHAPDVPVVELVTGEDSVVL---EKDESGVT 417 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 VTRVI+ G R R LA+ GDTVLLAPAGASFDQF+GYG RGD Sbjct: 418 RVTRVIQTGDRTLADAVMTAAVDAARGLATSGDTVLLAPAGASFDQFTGYGHRGD 472 >tr|D5P6X1|D5P6X1_9MYCO Tax_Id=525368 (murD)SubName: Full=UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase; EC=6.3.2.9;[Mycobacterium parascrofulaceum ATCC BAA-614] Length = 488 Score = 524 bits (1350), Expect = e-146 Identities = 286/482 (59%), Positives = 321/482 (66%), Gaps = 5/482 (1%) Query: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAV 60 MP++ G L PL PGA VLV G G+TG+AVL AL+ G A Sbjct: 1 MPELPG-LGPLAPGAPVLVAGGGVTGKAVLAALSRFGAAPTLCDDDPATLRRYADTGAAT 59 Query: 61 IAPGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRR 120 A + +YALVVTSPGF GVP+WGDVELAWRLDAAGRYGPPRR Sbjct: 60 ATMSSATQRVAEYALVVTSPGFSPDTPLLVAAAAAGVPVWGDVELAWRLDAAGRYGPPRR 119 Query: 121 WLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 WLVV SMLH ML A GRRSVLCGNIGDPVL VLD+PA+LLAVELSSFQLHW Sbjct: 120 WLVVTGTNGKTTTTSMLHAMLTAAGRRSVLCGNIGDPVLDVLDRPADLLAVELSSFQLHW 179 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APS+RPEAGVVLN+AEDHLDWH +MA Y KARVLDGRVAVVGLDD AA LL TAAA Sbjct: 180 APSVRPEAGVVLNIAEDHLDWHATMAEYTAAKARVLDGRVAVVGLDDARAAALLDTAAAP 239 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFRLG+PAAGELGVRDG+LIDRAF D + L I V GP+ Sbjct: 240 VRVGFRLGEPAAGELGVRDGRLIDRAFADDLALLPVDSIPVPGPVGILDALAAAALARSV 299 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 +F+VGRHRAEV+ DGV ++DDSKATNPHAA+AS+ AY RV+WVAGG Sbjct: 300 DVPAEAIADAIAAFRVGRHRAEVIAVADGVTYVDDSKATNPHAAEASVLAYPRVIWVAGG 359 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGASVD V ++A RL GAVLIGRDRQ VA+ALSRHAPDVPVV++V GED+ + N Sbjct: 360 LLKGASVDAEVARMAPRLVGAVLIGRDRQEVAEALSRHAPDVPVVQVVTGEDADM---NA 416 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 + + VT V GG R+LA PGDTVLLAPAGASFDQFSGY R Sbjct: 417 TAVVIDVDVTEVKPSGG-DLGASVMSAAVAAARNLARPGDTVLLAPAGASFDQFSGYADR 475 Query: 481 GD 482 GD Sbjct: 476 GD 477 >sp|A0QF50|MURD_MYCA1 Tax_Id=243243 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium avium] Length = 489 Score = 522 bits (1344), Expect = e-146 Identities = 284/475 (59%), Positives = 317/475 (66%), Gaps = 4/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 LAPL+PGA VLV G GITGRAVL AL GV ++ A Sbjct: 8 LAPLSPGAPVLVAGGGITGRAVLAALRRFGAAPTLCDDDPATLRGYVDSGVDTVSTSAAA 67 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVVTSPGF GVP+WGDVELAWRLDAAG YGPPRRWLVV Sbjct: 68 ERISRYALVVTSPGFAPTAPLPLAAAAAGVPVWGDVELAWRLDAAGHYGPPRRWLVVTGT 127 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML A GRRS+LCGNIG PVL VLDQPAELLAVELSSFQLHWAPSLRPE Sbjct: 128 NGKTTTTSMLHAMLTAAGRRSLLCGNIGSPVLDVLDQPAELLAVELSSFQLHWAPSLRPE 187 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 G VLN+AEDHLDWHG++A YA KARVLDGRVAVVGLDD AA LL TA A VRVGFRL Sbjct: 188 GGAVLNIAEDHLDWHGTLADYAAAKARVLDGRVAVVGLDDSRAAALLSTARAPVRVGFRL 247 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVR G+L+DRAF D + L I V GP+ Sbjct: 248 GEPAAGELGVRGGQLVDRAFADDLTLLPVDSIPVPGPVGVLDALAAAALARCVDVPASPI 307 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGASV Sbjct: 308 AEAIVSFRVGRHRAEVVAVADGITYVDDSKATNPHAAEASVLAYPRVVWIAGGLLKGASV 367 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 D +V ++A+RL GAVLIGRDR+ VA+ALSRHAPDVPVV +V GED+G+ T G Sbjct: 368 DAVVARMASRLVGAVLIGRDRREVAEALSRHAPDVPVVHVVTGEDAGMDATPVVF---GA 424 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 +VT+V +GG RDLA PGDTVLLAPA ASFDQF+GY RGD Sbjct: 425 NVTKVKHLGG-DLGAAVMSAAVAAARDLAKPGDTVLLAPAAASFDQFAGYADRGD 478 >tr|A4TBF3|A4TBF3_MYCGI Tax_Id=350054 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium gilvum] Length = 487 Score = 519 bits (1337), Expect = e-145 Identities = 282/481 (58%), Positives = 320/481 (66%), Gaps = 8/481 (1%) Query: 2 PDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVI 61 PDV DLA G VLVTGA +TG+A+L AL PL +GV V+ Sbjct: 4 PDVD-DLA----GLSVLVTGARVTGQAILAALTPLGARATLTDDSPTALTAFAQQGVEVL 58 Query: 62 APGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRW 121 P A+ I + LVVTSPGF GVPIWGDVELAWRLD +GR+GPPR+W Sbjct: 59 DPAAAVERIAAFDLVVTSPGFPPTAPVLAAAADAGVPIWGDVELAWRLDRSGRFGPPRQW 118 Query: 122 LVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWA 181 LVV SMLH ML + GRR+VLCGNIGDPVL +L+QPA++ AVELSSFQLHWA Sbjct: 119 LVVTGTNGKTTTTSMLHAMLESAGRRAVLCGNIGDPVLTLLEQPADVFAVELSSFQLHWA 178 Query: 182 PSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATV 241 PSLRPEAG VLNVAEDHLDWHGSMAAYA DKAR L GRVAV GLDD +AAGLL +A A V Sbjct: 179 PSLRPEAGAVLNVAEDHLDWHGSMAAYAADKARALTGRVAVGGLDDEIAAGLLGSAPAAV 238 Query: 242 RVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXX 301 +VGFRLG P GE GVRDG LID AF DG+ELA I VAGP+ Sbjct: 239 KVGFRLGAPGPGEFGVRDGALIDNAFADGLELAAVDSIPVAGPVGVLNALAAAALARAVD 298 Query: 302 XXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGL 361 FQVGRHRAEVV DG+ ++DDSKATNPHAA+ASI AY RVVW+AGG+ Sbjct: 299 VPAEAIATALAGFQVGRHRAEVVAVADGITYVDDSKATNPHAARASIDAYPRVVWIAGGM 358 Query: 362 LKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNES 421 LKGASV++LV A+ L GAVLIGRDR +VA+AL+RHAPDVPVVELV GEDSGVL E Sbjct: 359 LKGASVEDLVSDSADHLVGAVLIGRDRAVVAEALARHAPDVPVVELVTGEDSGVL---EK 415 Query: 422 IESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 ES VTRV++ R LA+PGD +LLAPAGASFDQF+ YG RG Sbjct: 416 DESGVTRVTRVVQADSESLSDAVMAAAVRAARGLAAPGDAILLAPAGASFDQFTSYGHRG 475 Query: 482 D 482 D Sbjct: 476 D 476 >sp|Q73YQ6|MURD_MYCPA Tax_Id=1770 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium paratuberculosis] Length = 489 Score = 516 bits (1330), Expect = e-144 Identities = 282/475 (59%), Positives = 315/475 (66%), Gaps = 4/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 LAPL+PGA VLV G GITGRAVL AL GV ++ A Sbjct: 8 LAPLSPGAPVLVAGGGITGRAVLAALRRFGAAPTLCDDDPATLRGYVDSGVDTVSTSAAA 67 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVVTSPGF GVP+WGDVELAWRLD AG YGPPRRWLVV Sbjct: 68 ERISRYALVVTSPGFAPTAPLPLAAAAAGVPVWGDVELAWRLDVAGHYGPPRRWLVVTGT 127 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML A GRRS+LCGNIG PVL VLDQPAELLAVELSSFQLHWAPSLRPE Sbjct: 128 NGKTTTTSMLHAMLTAAGRRSLLCGNIGSPVLDVLDQPAELLAVELSSFQLHWAPSLRPE 187 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 G VLN+AEDHLDWHG++A YA KARVLDGRVAVVGLDD AA LL TA A VRVGFRL Sbjct: 188 GGAVLNIAEDHLDWHGTLADYAAAKARVLDGRVAVVGLDDSRAAALLSTARAPVRVGFRL 247 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVR G+L+DRAF D + L I V GP+ Sbjct: 248 GEPAAGELGVRGGQLVDRAFADDLTLLPVDSIPVPGPVGVLDALAAAALARCVDVPASPI 307 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGASV Sbjct: 308 AEAIVSFRVGRHRAEVVAVADGITYVDDSKATNPHAAEASVLAYPRVVWIAGGLLKGASV 367 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 D V ++A+ L GAVLIGRDR+ VA+ALSRHAPDVPVV +V GED+G+ T G Sbjct: 368 DAEVARMASWLVGAVLIGRDRREVAEALSRHAPDVPVVHVVTGEDAGMDATPVVF---GA 424 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 +VT+V +GG RDLA PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 425 NVTKVKHLGG-DLGAAVMSAAVAAARDLAKPGDTVLLAPAGASFDQFAGYADRGE 478 >tr|B2HGR8|B2HGR8_MYCMM Tax_Id=216594 (murD)SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;[Mycobacterium marinum] Length = 488 Score = 503 bits (1295), Expect = e-140 Identities = 279/483 (57%), Positives = 315/483 (65%), Gaps = 15/483 (3%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV GA +TGRAVL AL GVA + P A+ Sbjct: 2 LDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAV 61 Query: 68 ASIGD--------YALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPR 119 + YALVVTSPGF GVPIWGDVELAWRLDAAG YGPPR Sbjct: 62 QQLAQPEASPESRYALVVTSPGFQPSTPVLAAAAAAGVPIWGDVELAWRLDAAGCYGPPR 121 Query: 120 RWLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLH 179 RWLVV SMLH MLVAG RSVLCGNIG PVL VL++PA+LLAVELSSFQLH Sbjct: 122 RWLVVTGTNGKTTTTSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLH 181 Query: 180 WAPSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAA 239 WAPSLRPEAGVVLN+AEDHLDWHG+MAAY KARVL GRVAVVGLDD AA L TA A Sbjct: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPA 241 Query: 240 TVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXX 299 VRVGFR+G PA GELG+RDG L+DRAF D + L + I V GP+ Sbjct: 242 PVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPVGVLDTLAAAALARA 301 Query: 300 XXXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAG 359 SFQVGRHR+EVV VDG+ ++DDSKATNPHAA+AS+ AY RVVWVAG Sbjct: 302 VGVSADAIADAVASFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 Query: 360 GLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTN 419 GLLKGASVD V ++A+RL GAVLIG+DR VA+ALSRHAPDVPVV++V ED+ Sbjct: 362 GLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDA------ 415 Query: 420 ESIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQ 479 + E+ G VT+V +VGG R++A GDTVLLAPAGASFDQF+ YG Sbjct: 416 DMGEACGASVTKVDDVGG-SLGARVMRAAVAAARNMARSGDTVLLAPAGASFDQFTSYGD 474 Query: 480 RGD 482 RGD Sbjct: 475 RGD 477 >tr|A0PTI9|A0PTI9_MYCUA Tax_Id=362242 (murD)SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;[Mycobacterium ulcerans] Length = 488 Score = 499 bits (1285), Expect = e-139 Identities = 278/483 (57%), Positives = 313/483 (64%), Gaps = 15/483 (3%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV GA +TGRAVL AL GVA + P A+ Sbjct: 2 LDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAV 61 Query: 68 ASIGD--------YALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPR 119 + YALVVTSPGF GVPIWGDVELAWRLDAAG YGPPR Sbjct: 62 QQLAQPEPSSESRYALVVTSPGFQPSTPVLAAAAAAGVPIWGDVELAWRLDAAGCYGPPR 121 Query: 120 RWLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLH 179 RWLVV SMLH MLVAG RSVLCGNIG PVL VL++PA+LLAVELSSFQL Sbjct: 122 RWLVVTGTNGKTTTTSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLR 181 Query: 180 WAPSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAA 239 WAPSLRPEAGVVLN+AEDHLDWHG+MAAY KARVL GRVAVVGLDD AA L TA A Sbjct: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPA 241 Query: 240 TVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXX 299 VRVGFR+G PA GELG+RDG L+DRAF D + L + I V GP+ Sbjct: 242 PVRVGFRIGTPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPVGVLDTLAAAALARA 301 Query: 300 XXXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAG 359 SFQVGRHR+EVV VDG+ ++DDSKATNPHAA+AS+ AY RVVWVAG Sbjct: 302 VGVSADAIADAVASFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 Query: 360 GLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTN 419 GLLKGASVD V ++A RL GAVLIG+DR VA+ALSRHAPDVPVV++V ED+ Sbjct: 362 GLLKGASVDAEVARMAARLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDA------ 415 Query: 420 ESIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQ 479 + E+ G VT+V +VGG R++A GDTVLLAPAGASFDQF+ YG Sbjct: 416 DMGEAYGASVTKVDDVGG-SLGARVMRAAVAAARNMARSGDTVLLAPAGASFDQFTSYGD 474 Query: 480 RGD 482 RGD Sbjct: 475 RGD 477 >tr|C6DPQ3|C6DPQ3_MYCTK Tax_Id=478434 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis] Length = 489 Score = 491 bits (1263), Expect = e-136 Identities = 270/482 (56%), Positives = 308/482 (63%), Gaps = 4/482 (0%) Query: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAV 60 MPDV L PL PGA VLV G +TG+AV L +G+ Sbjct: 1 MPDV---LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPT 57 Query: 61 IAPGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRR 120 ++ DA+ I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR Sbjct: 58 VSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRS 117 Query: 121 WLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 WLVV SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHW Sbjct: 118 WLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHW 177 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A Sbjct: 178 APSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQ 237 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFRLG+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 238 VRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSV 297 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGG Sbjct: 298 GVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGG 357 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGAS+ V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E Sbjct: 358 LLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVE 417 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 + V + + G R +A PGDTVLLAPAGASFDQF+GY R Sbjct: 418 VPVACVLDVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADR 476 Query: 481 GD 482 G+ Sbjct: 477 GE 478 >tr|D6G6J2|D6G6J2_MYCTU Tax_Id=478435 SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;[Mycobacterium tuberculosis KZN 605] Length = 489 Score = 491 bits (1263), Expect = e-136 Identities = 270/482 (56%), Positives = 308/482 (63%), Gaps = 4/482 (0%) Query: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAV 60 MPDV L PL PGA VLV G +TG+AV L +G+ Sbjct: 1 MPDV---LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPT 57 Query: 61 IAPGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRR 120 ++ DA+ I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR Sbjct: 58 VSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRS 117 Query: 121 WLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 WLVV SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHW Sbjct: 118 WLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHW 177 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A Sbjct: 178 APSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQ 237 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFRLG+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 238 VRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSV 297 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGG Sbjct: 298 GVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGG 357 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGAS+ V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E Sbjct: 358 LLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVE 417 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 + V + + G R +A PGDTVLLAPAGASFDQF+GY R Sbjct: 418 VPVACVLDVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADR 476 Query: 481 GD 482 G+ Sbjct: 477 GE 478 >tr|A4KIT3|A4KIT3_MYCTU Tax_Id=395095 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis str. Haarlem] Length = 496 Score = 489 bits (1259), Expect = e-136 Identities = 269/482 (55%), Positives = 308/482 (63%), Gaps = 4/482 (0%) Query: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAV 60 +PDV L PL PGA VLV G +TG+AV L +G+ Sbjct: 8 VPDV---LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPT 64 Query: 61 IAPGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRR 120 ++ DA+ I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR Sbjct: 65 VSSSDAVQQITGYALVVASPGFSPAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRS 124 Query: 121 WLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 WLVV SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHW Sbjct: 125 WLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHW 184 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A Sbjct: 185 APSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQ 244 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFRLG+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 245 VRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSV 304 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGG Sbjct: 305 GVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGG 364 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGAS+ V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E Sbjct: 365 LLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVE 424 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 + V + + G R +A PGDTVLLAPAGASFDQF+GY R Sbjct: 425 VPVACVLDVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADR 483 Query: 481 GD 482 G+ Sbjct: 484 GE 485 >tr|A2VJQ2|A2VJQ2_MYCTU Tax_Id=348776 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis C] Length = 496 Score = 489 bits (1259), Expect = e-136 Identities = 269/482 (55%), Positives = 308/482 (63%), Gaps = 4/482 (0%) Query: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAV 60 +PDV L PL PGA VLV G +TG+AV L +G+ Sbjct: 8 VPDV---LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPT 64 Query: 61 IAPGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRR 120 ++ DA+ I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR Sbjct: 65 VSSSDAVQQITGYALVVASPGFSPAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRS 124 Query: 121 WLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 WLVV SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHW Sbjct: 125 WLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHW 184 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A Sbjct: 185 APSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQ 244 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFRLG+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 245 VRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSV 304 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGG Sbjct: 305 GVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGG 364 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGAS+ V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E Sbjct: 365 LLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVE 424 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 + V + + G R +A PGDTVLLAPAGASFDQF+GY R Sbjct: 425 VPVACVLDVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADR 483 Query: 481 GD 482 G+ Sbjct: 484 GE 485 >sp|C1AQ71|MURD_MYCBT Tax_Id=561275 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >sp|A1KKJ8|MURD_MYCBP Tax_Id=410289 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >sp|Q7VEP7|MURD_MYCBO Tax_Id=1765 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >tr|A5WPC7|A5WPC7_MYCTF Tax_Id=336982 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >tr|D6FWH3|D6FWH3_MYCTU Tax_Id=611304 SubName: Full=UDP-N-acetylMuramoylalanine-D-glutamate ligase MurD;[Mycobacterium tuberculosis K85] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >tr|D6F5T4|D6F5T4_MYCTU Tax_Id=611302 SubName: Full=UDP-N-acetylMuramoylalanine-D-glutamate ligase;[Mycobacterium tuberculosis T46] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >tr|D5YGY6|D5YGY6_MYCTU Tax_Id=520140 SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;[Mycobacterium tuberculosis EAS054] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >tr|D5Y4Z6|D5Y4Z6_MYCTU Tax_Id=520141 SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;[Mycobacterium tuberculosis T85] Length = 486 Score = 488 bits (1255), Expect = e-135 Identities = 266/475 (56%), Positives = 304/475 (64%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >sp|O06222|MURD_MYCTU Tax_Id=1773 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium tuberculosis] Length = 486 Score = 484 bits (1247), Expect = e-135 Identities = 265/475 (55%), Positives = 303/475 (63%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAA ELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >sp|A5U4I2|MURD_MYCTA Tax_Id=419947 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium tuberculosis] Length = 486 Score = 484 bits (1247), Expect = e-135 Identities = 265/475 (55%), Positives = 303/475 (63%), Gaps = 1/475 (0%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L PL PGA VLV G +TG+AV L +G+ ++ DA+ Sbjct: 2 LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAV 61 Query: 68 ASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 62 QQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPE 187 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPE Sbjct: 122 NGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPE 181 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRL Sbjct: 182 AGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRL 241 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G+PAA ELGVRD L+DRAF D + L A I V GP+ Sbjct: 242 GEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAI 301 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 302 ADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASL 361 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + Sbjct: 362 HAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVL 421 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 V + + G R +A PGDTVLLAPAGASFDQF+GY RG+ Sbjct: 422 DVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGE 475 >sp|P57995|MURD_MYCLE Tax_Id=1769 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium leprae] Length = 490 Score = 478 bits (1229), Expect = e-132 Identities = 270/482 (56%), Positives = 307/482 (63%), Gaps = 11/482 (2%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L L PGA VLV G G+TGRAVL AL + GVA ++ A Sbjct: 2 LDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQQYADNGVATVSAATAT 61 Query: 68 ASIGD----YALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLV 123 + + Y LVVTSPGF VPIWGDVELAWRLDAAG YGPPRRWLV Sbjct: 62 QQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLV 121 Query: 124 VXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQ---PAELLAVELSSFQLHW 180 V SMLH ML A RRS+LCGNIG PVL VL + P++ LAVELSSFQLHW Sbjct: 122 VTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHW 181 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAGVVLN+AEDHLDWH +MA Y KARVL GRVAVVGLDD AA LL T A Sbjct: 182 APSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAP 241 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFR G+PA GELGVRDG L+DRAF + + L I V+GP+ Sbjct: 242 VRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAALARSV 301 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 F++GRHRAEVV DG+ ++DDSKATNPHAA S+ AY RVVWVAGG Sbjct: 302 GVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGG 361 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGASVD V ++A +L GAVLIGRDR MVA+ALSRHAP+VPVV++VAGED+G+ Sbjct: 362 LLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAV-- 419 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 ++ S G V + +VGG RDLA PGDTVLLAPAGASFDQFSGY R Sbjct: 420 AVVS-GTDVISISDVGG-TIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYADR 477 Query: 481 GD 482 GD Sbjct: 478 GD 479 >sp|B8ZQP8|MURD_MYCLB Tax_Id=561304 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium leprae] Length = 490 Score = 478 bits (1229), Expect = e-132 Identities = 270/482 (56%), Positives = 307/482 (63%), Gaps = 11/482 (2%) Query: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAI 67 L L PGA VLV G G+TGRAVL AL + GVA ++ A Sbjct: 2 LDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQQYADNGVATVSAATAT 61 Query: 68 ASIGD----YALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLV 123 + + Y LVVTSPGF VPIWGDVELAWRLDAAG YGPPRRWLV Sbjct: 62 QQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLV 121 Query: 124 VXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQ---PAELLAVELSSFQLHW 180 V SMLH ML A RRS+LCGNIG PVL VL + P++ LAVELSSFQLHW Sbjct: 122 VTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHW 181 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAGVVLN+AEDHLDWH +MA Y KARVL GRVAVVGLDD AA LL T A Sbjct: 182 APSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLSTTVAP 241 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFR G+PA GELGVRDG L+DRAF + + L I V+GP+ Sbjct: 242 VRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAALARSV 301 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 F++GRHRAEVV DG+ ++DDSKATNPHAA S+ AY RVVWVAGG Sbjct: 302 GVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVVWVAGG 361 Query: 361 LLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNE 420 LLKGASVD V ++A +L GAVLIGRDR MVA+ALSRHAP+VPVV++VAGED+G+ Sbjct: 362 LLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAV-- 419 Query: 421 SIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQR 480 ++ S G V + +VGG RDLA PGDTVLLAPAGASFDQFSGY R Sbjct: 420 AVVS-GTDVISISDVGG-TIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYADR 477 Query: 481 GD 482 GD Sbjct: 478 GD 479 >tr|B1MP35|B1MP35_MYCA9 Tax_Id=561007 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium abscessus] Length = 488 Score = 462 bits (1190), Expect = e-128 Identities = 254/481 (52%), Positives = 295/481 (61%), Gaps = 9/481 (1%) Query: 5 TGDLAPLTPGARVLVTGAGITGRAVLGAL---APLEVXXXXXXXXXXXXXXXXXKGVAVI 61 T ++A LT G RVLV GA +TG AV+ AL A L + G + Sbjct: 3 TCEVAELTGGTRVLVCGARVTGDAVVAALTGLADLGLRITVCDDDEDALQRHRDAGHGAL 62 Query: 62 APGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRW 121 A + D LV+ SPGF G+PIWGDVELAWRLDA+GRYG P+RW Sbjct: 63 TTAAAQRHMADQDLVIVSPGFGPSAPVVQAAVQAGLPIWGDVELAWRLDASGRYGRPKRW 122 Query: 122 LVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWA 181 +VV +M+HDML A G S LCGNIGDPVL VLD+ E LAVELSSFQLHWA Sbjct: 123 VVVTGTNGKTTTTAMVHDMLTAAGGTSALCGNIGDPVLNVLDRDVEFLAVELSSFQLHWA 182 Query: 182 PSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATV 241 PS+RP AG VLNVAEDHLDWHG M Y RDKAR LDG VAV GLDD +A GLL AAA V Sbjct: 183 PSVRPVAGAVLNVAEDHLDWHGGMEGYTRDKARALDGEVAVAGLDDAIAGGLLAAAAAPV 242 Query: 242 RVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXX 301 + GFR G+PA GELGV DG L+DRAF + L + + + V GPI Sbjct: 243 KAGFRAGEPAVGELGVLDGWLVDRAFGVDIPLIEVSKLPVGGPIGVLNALAAAALARAVG 302 Query: 302 XXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGL 361 FQVGRHRAE++ V V ++DDSKATNPHAA ASI Y RVVW+AGGL Sbjct: 303 TPAVHIARALEVFQVGRHRAELIARVADVAYVDDSKATNPHAAAASIAGYPRVVWIAGGL 362 Query: 362 LKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNES 421 LKGA+VD+LVR A+RL VLIGRDR ++A+AL+RHAPDVPVV +V ED+GV N Sbjct: 363 LKGAAVDDLVRDCADRLGAVVLIGRDRALIAEALARHAPDVPVVAVVTREDAGVQEANVV 422 Query: 422 IESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 +VT + GG LA PGDTVLLAPAGASFDQFSGY +RG Sbjct: 423 ------YVTDEADGGGADLGTRVMAAAVRHASSLARPGDTVLLAPAGASFDQFSGYSERG 476 Query: 482 D 482 D Sbjct: 477 D 477 >tr|D6FI51|D6FI51_MYCTU Tax_Id=611303 SubName: Full=UDP-N-acetylMuramoylalanine-D-glutamate ligase MurD;[Mycobacterium tuberculosis CPHL_A] Length = 426 Score = 458 bits (1179), Expect = e-127 Identities = 247/413 (59%), Positives = 278/413 (67%), Gaps = 1/413 (0%) Query: 70 IGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXX 129 I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 4 ITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNG 63 Query: 130 XXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPEAG 189 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPEAG Sbjct: 64 KTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPEAG 123 Query: 190 VVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLGD 249 VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRLG+ Sbjct: 124 AVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGE 183 Query: 250 PAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXXXX 309 PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 184 PAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIAD 243 Query: 310 XXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVDE 369 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 244 AVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHA 303 Query: 370 LVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGDHV 429 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + V Sbjct: 304 EVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDV 363 Query: 430 TRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 + + G R +A PGDTVLLAPAGASFDQF+ Y RG+ Sbjct: 364 AK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTAYADRGE 415 >tr|D5XUS2|D5XUS2_MYCTU Tax_Id=515617 SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD; Flags: Fragment;[Mycobacterium tuberculosis T92] Length = 411 Score = 448 bits (1152), Expect = e-124 Identities = 243/408 (59%), Positives = 273/408 (66%), Gaps = 1/408 (0%) Query: 70 IGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXX 129 I YAL PGF GVPIWGDVELAWRLDAAG YGPPR WLVV Sbjct: 4 ITGYALWSPVPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNG 63 Query: 130 XXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPEAG 189 SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHWAPSLRPEAG Sbjct: 64 KTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPEAG 123 Query: 190 VVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLGD 249 VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A VRVGFRLG+ Sbjct: 124 AVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGE 183 Query: 250 PAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXXXX 309 PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 184 PAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIAD 243 Query: 310 XXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVDE 369 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY RVVW+AGGLLKGAS+ Sbjct: 244 AVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHA 303 Query: 370 LVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGDHV 429 V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED+G+ T E + V Sbjct: 304 EVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDV 363 Query: 430 TRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGY 477 + + G R +A PGDTVLLAPAGASFDQF+GY Sbjct: 364 AK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGY 410 >tr|C1AU57|C1AU57_RHOOB Tax_Id=632772 (murD)SubName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus opacus] Length = 499 Score = 403 bits (1035), Expect = e-110 Identities = 228/474 (48%), Positives = 273/474 (57%), Gaps = 13/474 (2%) Query: 14 GARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIAS---I 70 G VLV GAG++GRA + L L +G A + D +A + Sbjct: 13 GRSVLVAGAGVSGRATIEPLRDLGAHVTVTDSNVDALAECARRGAATVPIDDLLAEREKV 72 Query: 71 GDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXXX 130 ++ALVVTSPGF GVPIWGD+E +W +D AG YGPPRRWLVV Sbjct: 73 AEFALVVTSPGFRPDAPLLSAAAGDGVPIWGDIEFSWHVDRAGLYGPPRRWLVVTGTNGK 132 Query: 131 XXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQP---AELLAVELSSFQLHWAPSLRPE 187 SML +L A G S+ CGNIG PVL L AE+LAVELSSFQLHWAPS+RP Sbjct: 133 TTTTSMLQSILEAAGLPSLACGNIGLPVLDALRPTGPRAEVLAVELSSFQLHWAPSVRPT 192 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG +LN+AEDHLDWHG M Y KAR L G VAV+GLDD VA+ L ++ A +GFRL Sbjct: 193 AGAILNIAEDHLDWHGGMQPYIDAKARALTGEVAVLGLDDEVASSLFSSSLAVRTLGFRL 252 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G PAAGELGV DG L+DRAF DG LA I GP Sbjct: 253 GVPAAGELGVEDGYLVDRAFADGERLAPADGITPPGPAGLMDALAAAALARAIGVPPDAV 312 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 + VG HRA V V GV F+DDSKATNPHAA+ SI A+DRVVW+AGGLLKGA V Sbjct: 313 AAGLAAHVVGPHRAARVAEVGGVTFVDDSKATNPHAARPSILAHDRVVWIAGGLLKGARV 372 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 D+LVR+VA RLAGAVL+GRD + +A++L+RHAP+VPVV + G+D+GV +V Sbjct: 373 DDLVREVAGRLAGAVLLGRDARQIAESLARHAPEVPVVTVETGDDAGV-------SAVPQ 425 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 T + + LAS GD V+LAPA AS D F YG RG Sbjct: 426 TATHRVVLAADTDSDAVMGVVVREAAALASAGDAVVLAPAAASLDMFDSYGHRG 479 >sp|Q0SHR9|MURD_RHOSR Tax_Id=101510 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Rhodococcus sp.] Length = 499 Score = 401 bits (1030), Expect = e-109 Identities = 227/475 (47%), Positives = 274/475 (57%), Gaps = 13/475 (2%) Query: 14 GARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIAS---I 70 G VLV GAG++GRA + L L G A + D +A + Sbjct: 13 GRSVLVAGAGVSGRATIEPLRDLGALVTVTDANVDALAECARLGAATVPIDDLLAERDRV 72 Query: 71 GDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXXX 130 ++ALVVTSPGF GVPIWGD+E +W +D AG YGPPRRWLVV Sbjct: 73 AEFALVVTSPGFRPDAPLLSLAAGDGVPIWGDIEFSWHVDRAGLYGPPRRWLVVTGTNGK 132 Query: 131 XXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQP---AELLAVELSSFQLHWAPSLRPE 187 SML +L A S+ CGNIG PVL L Q AE LAVELSSFQLHWAPS+RP Sbjct: 133 TTTTSMLQSILEAAELPSLACGNIGIPVLDALRQTEPRAEALAVELSSFQLHWAPSVRPT 192 Query: 188 AGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRL 247 AG +LN+AEDHLDWHG M Y KAR L G VAV+GLDD VA+ L ++ A VGFRL Sbjct: 193 AGAILNIAEDHLDWHGGMQPYIDAKARALTGEVAVLGLDDEVASSLFSSSPAVRTVGFRL 252 Query: 248 GDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXX 307 G PA GELGV DG L+DRAF DG LA I GP Sbjct: 253 GVPAPGELGVEDGYLVDRAFADGERLAPAEGITPPGPAGLMDALAAAALARAIGVPPDAV 312 Query: 308 XXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASV 367 + VG HRA +V V GV F+DDSKATNPHAA+ SI A++RVVW+AGGLLKGA V Sbjct: 313 AAGLAAHVVGPHRAALVAEVGGVTFVDDSKATNPHAARPSILAHERVVWIAGGLLKGARV 372 Query: 368 DELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGD 427 D+LVR+VA+RLAGAVL+GRD +A++L+RHAP+VPVV + G+D+GV +V Sbjct: 373 DDLVREVASRLAGAVLLGRDAMQIAESLARHAPEVPVVTVETGDDAGV-------SAVPQ 425 Query: 428 HVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 T + + LA+ GD+V+LAPA AS D F+ YG RGD Sbjct: 426 TATHRVVLPADTDSDAVMGVVVREAAALATAGDSVVLAPAAASLDMFASYGHRGD 480 >tr|C3JJ50|C3JJ50_RHOER Tax_Id=596309 (murD)SubName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus erythropolis SK121] Length = 507 Score = 400 bits (1028), Expect = e-109 Identities = 232/486 (47%), Positives = 284/486 (58%), Gaps = 14/486 (2%) Query: 3 DVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIA 62 D DL+ L G RVLV G ++G+A + L L G ++ Sbjct: 6 DSENDLSWLR-GTRVLVAGGRVSGQATIEPLVALGAVVTVADSTLDFAERCAELGADMVT 64 Query: 63 PG---DAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPR 119 DA SI +Y LVVTSPGF G+PIWGDVE +WR+D +G +G PR Sbjct: 65 TTSIEDAPDSITEYGLVVTSPGFRPDAPILAAAAGHGIPIWGDVEFSWRVDHSGHFGTPR 124 Query: 120 RWLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPA---ELLAVELSSF 176 +WLVV SML +L G CGNIG P+L L + + E LAVELSSF Sbjct: 125 KWLVVTGTNGKTTTTSMLASILDGAGVVGRACGNIGLPILDALAETSPRVEYLAVELSSF 184 Query: 177 QLHWAPSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPT 236 QLHWAPS+RP+AGVVLNVAEDHLDWHG M+AYA K+R L GRVAVVGLDD +A+ L Sbjct: 185 QLHWAPSVRPDAGVVLNVAEDHLDWHGGMSAYAEAKSRALSGRVAVVGLDDAIASELGTR 244 Query: 237 AAATVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXX 296 A A + GFRLG+P GELGV G L+D AF D V LA+ A I AGP Sbjct: 245 ATADIVTGFRLGEPGEGELGVEAGHLVDNAFGDHVRLAEAASIDPAGPAGVMDALAAAAL 304 Query: 297 XXXXXXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVW 356 + +VG HR +VG V VV+IDDSKATNPHAA+ SI A+DRVVW Sbjct: 305 ARALGFEADVVERGLAAHKVGPHRGALVGRVGSVVYIDDSKATNPHAARPSILAHDRVVW 364 Query: 357 VAGGLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVL 416 VAGGLLKGASVD+LV +V RL+GAVL+GRD ++ DAL+RHAPDVPVV +++G+D+ V+ Sbjct: 365 VAGGLLKGASVDQLVSEVGPRLSGAVLLGRDAGVIEDALARHAPDVPVVHVMSGDDA-VV 423 Query: 417 GTNESIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSG 476 N S + T I + +LASPGD V+LAPA AS D F+ Sbjct: 424 SENSS------NSTLTIRLPSGADADAVMAAVVVEAAELASPGDAVVLAPAAASLDMFAS 477 Query: 477 YGQRGD 482 YG RGD Sbjct: 478 YGHRGD 483 >tr|D5PP41|D5PP41_COREQ Tax_Id=525370 (murD)SubName: Full=UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase; EC=6.3.2.9;[Rhodococcus equi ATCC 33707] Length = 503 Score = 400 bits (1027), Expect = e-109 Identities = 229/473 (48%), Positives = 273/473 (57%), Gaps = 8/473 (1%) Query: 14 GARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIAS---I 70 GARVLVTGAGI+GRAV+ L L G + + D A + Sbjct: 13 GARVLVTGAGISGRAVIAPLHDLGAHVTVTDTAADALARCAEAGASTVPVDDLAADPRRM 72 Query: 71 GDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXXX 130 ++ LVVTSPGF GVP+WGD+E W +D +G YGPPR+WLVV Sbjct: 73 AEFELVVTSPGFRPDAPVLAAAAAAGVPVWGDIEFTWHVDRSGMYGPPRQWLVVTGTNGK 132 Query: 131 XXXXSMLHDMLVAGGRRSVLCGNIGDPVL-AVLDQP-AELLAVELSSFQLHWAPSLRPEA 188 SMLH +L A G S CGNIG PVL A+ QP AE+LAVELSSFQLHWAPS+RP A Sbjct: 133 TTTTSMLHSILEAAGFVSAACGNIGLPVLDALRAQPRAEVLAVELSSFQLHWAPSVRPAA 192 Query: 189 GVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLG 248 GVVLN+AEDHLDWHG M Y KA+ L G VAVVGLDDPVAA L +GFRLG Sbjct: 193 GVVLNIAEDHLDWHGGMPGYIDAKAQALTGAVAVVGLDDPVAASLADRPRDGRTIGFRLG 252 Query: 249 DPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXXX 308 +P ELGV DG L+DRAF DG L +I GP Sbjct: 253 EPDPNELGVVDGVLVDRAFADGAALVPADEISPPGPAGVSDALAAAALARAIGVTTDAVA 312 Query: 309 XXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVD 368 + +VG HRA+VV T+ + F+DDSKATNPHAA++SI A+D VVW+AGGLLKGA VD Sbjct: 313 AGLRAHRVGPHRAQVVRTLAEITFVDDSKATNPHAARSSIVAHDSVVWIAGGLLKGARVD 372 Query: 369 ELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGDH 428 +LV +V R+AGAVLIGRD +ADAL+RHAP+VPVV + AG+D G G + E Sbjct: 373 DLVAEVGERIAGAVLIGRDAGAIADALARHAPEVPVVLVRAGDDGGHEGVDGPEEGADPA 432 Query: 429 VTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 + + LA+PGD VLLAPA AS D F YG RG Sbjct: 433 LHLDLPAADADTVMAEAVRTAAA---LAAPGDVVLLAPAAASLDMFDSYGHRG 482 >tr|C1A0X7|C1A0X7_RHOE4 Tax_Id=234621 (murD)SubName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus erythropolis] Length = 507 Score = 399 bits (1026), Expect = e-109 Identities = 229/486 (47%), Positives = 283/486 (58%), Gaps = 14/486 (2%) Query: 3 DVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIA 62 D DL+ L G RVLV G ++G+A + L L G ++ Sbjct: 6 DSENDLSWLR-GTRVLVAGGRVSGQATIEPLVALGAVVTVADSTLDFAQRCAELGADMVT 64 Query: 63 PG---DAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPR 119 DA SI +Y LVVTSPGF G+PIWGDVE +WR+D +G +G PR Sbjct: 65 TTSIEDAPDSITEYGLVVTSPGFRPDAPILAAAAGHGIPIWGDVEFSWRVDHSGHFGGPR 124 Query: 120 RWLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPA---ELLAVELSSF 176 +WLVV SML +L A G CGNIG P+L L + + E LAVELSSF Sbjct: 125 KWLVVTGTNGKTTTTSMLASILDAAGVVGRACGNIGLPILDALAETSPRVEYLAVELSSF 184 Query: 177 QLHWAPSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPT 236 QLHWAPS+RP+AGVVLNVAEDHLDWHG M+AYA K+R L G+VAVVGLDD +A+ L Sbjct: 185 QLHWAPSVRPDAGVVLNVAEDHLDWHGGMSAYAEAKSRALSGKVAVVGLDDAIASELGTR 244 Query: 237 AAATVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXX 296 A A + GFRLG+P GELGV G L+D AF D V LA+ A I AGP Sbjct: 245 ATADIVTGFRLGEPGEGELGVEAGHLVDNAFGDHVRLAEAASIDPAGPAGVMDALAAAAL 304 Query: 297 XXXXXXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVW 356 + +VG HR +VG V VV+IDDSKATNPHAA+ SI A+DRVVW Sbjct: 305 ARALGFEADVVERGLAAHKVGPHRGALVGRVGSVVYIDDSKATNPHAARPSILAHDRVVW 364 Query: 357 VAGGLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVL 416 VAGGLLKGASV++LV +V RL+GAVL+GRD ++ DAL+RHAPDVPVV +++G+D Sbjct: 365 VAGGLLKGASVEQLVSEVGPRLSGAVLLGRDAGVIEDALARHAPDVPVVHVLSGDD---- 420 Query: 417 GTNESIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSG 476 E++ + T I + +LASPGD V+LAPA AS D F+ Sbjct: 421 ---EAVSENSSNSTLTIRLPSGADADAVMAAVVVEAAELASPGDAVVLAPAAASLDMFAS 477 Query: 477 YGQRGD 482 YG RGD Sbjct: 478 YGHRGD 483 >tr|D5USH7|D5USH7_TSUPA Tax_Id=521096 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase;[Tsukamurella paurometabola DSM 20162] Length = 486 Score = 374 bits (961), Expect = e-101 Identities = 229/481 (47%), Positives = 274/481 (56%), Gaps = 25/481 (5%) Query: 13 PGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIASIGD 72 PGA VLV G G+TG AV AL L + +A P A+ + D Sbjct: 7 PGAHVLVAGGGVTGPAVARALLRLGAAVTVADGKPVAR-----EKIAAEVPEVAVVDLDD 61 Query: 73 -----YALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXX 127 YALVV +PGF GVP+ GDVELAW +D AG +G PR WLVV Sbjct: 62 LDPAGYALVVVAPGFRPTAPIVVAAQDAGVPVIGDVELAWWIDRAGAFGAPRDWLVVTGT 121 Query: 128 XXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAE--LLAVELSSFQLHWAPSLR 185 ML +L G +V CGNIG PV+ + A+ +LAVELSSFQLHWAPS+R Sbjct: 122 NGKTTTTQMLESILAHAGLPAVACGNIGRPVIDAIADAADPRVLAVELSSFQLHWAPSVR 181 Query: 186 PEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGF 245 P AGVVLN+AEDHLDWHGSMAAY DKAR L G +AVVGLDDPVAA L AAT GF Sbjct: 182 PRAGVVLNIAEDHLDWHGSMAAYTADKARALTGDIAVVGLDDPVAATL---PAAT---GF 235 Query: 246 RLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXX 305 +G+PA G+ GVR G LID A G + A + GP Sbjct: 236 TVGEPAPGQYGVRAGMLIDGA---GSSIVPAARVSPPGPAGIADALAATALAQAVGVTAA 292 Query: 306 XXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGA 365 F+VG HRAE V TV GV +IDDSKATNPHAAQ SI A++RVVWVAGG LKGA Sbjct: 293 QAGAALTQFRVGAHRAEPVATVRGVTYIDDSKATNPHAAQNSIEAHERVVWVAGGQLKGA 352 Query: 366 SVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLG-TNESIES 424 +D LV +VA+RLAGAVL+G D +++A A++RHAPDVPVV + +G+DS V TN++ S Sbjct: 353 DIDPLVARVASRLAGAVLLGVDAELIAAAMARHAPDVPVVRVTSGDDSRVSPVTNDASRS 412 Query: 425 VGDHVTRVIEVGG-RPXXXXXXXXXXXXXRDLASPGDT--VLLAPAGASFDQFSGYGQRG 481 +G V + V G D+A T VLLAPA AS D F YG RG Sbjct: 413 IGTSVAGDVRVSGDADAVMTAAVHAAAGLADVAGQSRTPVVLLAPAAASLDMFRSYGHRG 472 Query: 482 D 482 + Sbjct: 473 E 473 >tr|D5ZG53|D5ZG53_MYCTU Tax_Id=537210 SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;[Mycobacterium tuberculosis T17] Length = 395 Score = 374 bits (960), Expect = e-101 Identities = 204/381 (53%), Positives = 233/381 (61%), Gaps = 3/381 (0%) Query: 1 MPDVTGDLAPLTPGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAV 60 +PDV L PL PGA VLV G +TG+AV L +G+ Sbjct: 8 VPDV---LDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPT 64 Query: 61 IAPGDAIASIGDYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRR 120 ++ DA+ I YALVV SPGF GVPIWGDVELAWRLDAAG YGPPR Sbjct: 65 VSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRS 124 Query: 121 WLVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHW 180 WLVV SMLH ML+AGGRR+VLCGNIG VL VLD+PAELLAVELSSFQLHW Sbjct: 125 WLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHW 184 Query: 181 APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAAT 240 APSLRPEAG VLN+AEDHLDWH +MA Y KARVL G VAV GLDD AA LL + A Sbjct: 185 APSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQ 244 Query: 241 VRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXX 300 VRVGFRLG+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 245 VRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSV 304 Query: 301 XXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGG 360 SF+VGRHRA+ V DG+ + +DSKATNPHAAQ S+ Y RV W+ GG Sbjct: 305 GVPAGAIADAVTSFRVGRHRAKAVAVADGITYREDSKATNPHAAQPSVLDYPRVEWIEGG 364 Query: 361 LLKGASVDELVRQVANRLAGA 381 L KGAS + Q + +G+ Sbjct: 365 LHKGASFTPSLEQWVSFWSGS 385 >sp|Q5YYY1|MURD_NOCFA Tax_Id=37329 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Nocardia farcinica] Length = 480 Score = 363 bits (932), Expect = 3e-98 Identities = 218/471 (46%), Positives = 268/471 (56%), Gaps = 19/471 (4%) Query: 14 GARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDA-IASIGD 72 G VLV G GI+GR+++ L + G+ V + A + Sbjct: 7 GRDVLVAGWGISGRSLVEPLRDIGAHPVVTDSGAKALAEAAELGLEVATSVELESADLSR 66 Query: 73 YALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXXXXX 132 +ALV+TSPG+ G+P+WGDVE AW +D A YGP R+WLVV Sbjct: 67 FALVITSPGWRPDSPVLVSAVTEGIPVWGDVEFAWWVDQARIYGPVRKWLVVTGTNGKTT 126 Query: 133 XXSMLHDMLVAGGRRSVLCGNIGDPVLAVL--DQPAELLAVELSSFQLHWAPSLRPEAGV 190 M H +L A G SV CGNIG P+L L + ++LAVELSSFQLHWAPS+RPEAGV Sbjct: 127 TTQMTHAILRAAGIASVACGNIGLPILDALRRNPGPQVLAVELSSFQLHWAPSVRPEAGV 186 Query: 191 VLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLGDP 250 VLNVAEDHLDWHG + AYA KAR L GR+ VVGLDDPVAA L + A VGFR+G P Sbjct: 187 VLNVAEDHLDWHGGLDAYAAAKARALVGRIGVVGLDDPVAAALARRSKARRTVGFRVGVP 246 Query: 251 AAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXXXXX 310 A GELGV DGKL+DRAF LA+ DI GP Sbjct: 247 ADGELGVVDGKLLDRAFTKAAILAEVGDISPPGPAGVADALAAAALTRAIDVAPQFVKEG 306 Query: 311 XXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVDEL 370 +VG HRA V V GV FIDDSKATNPHAA++SI A+ VVW+AGG LKGA+V++L Sbjct: 307 LQEHKVGPHRAAFVREVAGVEFIDDSKATNPHAARSSILAHPHVVWIAGGRLKGAAVEDL 366 Query: 371 VRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGDHVT 430 V +VA+RL AVLIG D ++A AL+RHAP+VPVVE+ AG+D+ + ++ + D Sbjct: 367 VEEVADRLVAAVLIGVDAPVIAAALARHAPEVPVVEVRAGDDAVM--ADDPLRP--DEAD 422 Query: 431 RVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 V+ R A GDTVLLAPA AS D F+ Y RG Sbjct: 423 AVMAAAVRTAAGY------------ARAGDTVLLAPAAASLDMFADYTHRG 461 >tr|D0LAT4|D0LAT4_GORB4 Tax_Id=526226 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Gordonia bronchialis] Length = 512 Score = 346 bits (887), Expect = 5e-93 Identities = 219/491 (44%), Positives = 265/491 (53%), Gaps = 26/491 (5%) Query: 14 GARVLVTGAGITG----RAVLGA-----LAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPG 64 G V+V GAG G R +L A LA +G ++ Sbjct: 9 GRAVVVAGAGTAGMSAARFLLDAGAFVTLADARFAGEVAGSQIPGAAELRDRGAGLVTVD 68 Query: 65 DAIASIGDYA---LVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRW 121 D +A A LVV SPGF VP+WG+VELAWR+D AG GPPR W Sbjct: 69 DLLADDDWTARTDLVVVSPGFAPTHPVAVAAADGSVPVWGEVELAWRVDRAGILGPPRTW 128 Query: 122 LVVXXXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVL-AVLDQP-AELLAVELSSFQLH 179 LVV SML D++VAGGR + CGNIG PVL A+L P ++L ELSSFQLH Sbjct: 129 LVVTGTNGKTTTTSMLADIVVAGGRSGIACGNIGLPVLDAMLMAPRVDVLCAELSSFQLH 188 Query: 180 WAPSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAA 239 WAPS+RP+AGVVLNVAEDHLDWHG YA K R L G V+VVGLDD VA GL PT Sbjct: 189 WAPSVRPDAGVVLNVAEDHLDWHGGFDGYAGAKTRALTGAVSVVGLDDEVAGGL-PTQGR 247 Query: 240 TVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXX 299 RVGF LG+P +LGV +L+DRAF GV LA A I GP Sbjct: 248 --RVGFTLGEPGPDDLGVVGAELVDRAFGSGVLLAAEA-IHPPGPSGLSDALAASALALA 304 Query: 300 XXXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAG 359 +F+ HR EVV G+ F+DDSKATNPHAAQA+I +DRVV +AG Sbjct: 305 AGVDRAAVADALTAFRPAGHRGEVVAESAGIRFVDDSKATNPHAAQAAIAGFDRVVLIAG 364 Query: 360 GLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGV---- 415 GLLKGASVD ++ V +RLAG V IG+DR ++ DA++RHAP+VP V + G+D GV Sbjct: 365 GLLKGASVDRMIDAVRHRLAGVVAIGQDRDIIVDAIARHAPEVPTVTVFTGDDGGVNVHR 424 Query: 416 LGTNESIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGD----TVLLAPAGASF 471 + ++ S +H V LA D VLLAPA AS Sbjct: 425 MACARNLASARNHADPVSPGSPTDPAVAVMDRAVVEAWHLAGAADPTPQAVLLAPAAASL 484 Query: 472 DQFSGYGQRGD 482 D F+GYG+RGD Sbjct: 485 DMFAGYGRRGD 495 >tr|C6WDE4|C6WDE4_ACTMD Tax_Id=446462 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase; Flags: Precursor;[Actinosynnema mirum] Length = 450 Score = 321 bits (822), Expect = 2e-85 Identities = 200/470 (42%), Positives = 243/470 (51%), Gaps = 39/470 (8%) Query: 14 GARVLVTGAGITGRAVLGAL--APLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIASIG 71 G LV GAG+ GR+ AL A V GV ++A +A Sbjct: 6 GRSALVAGAGVAGRSAAEALLAAGATVTVTDSSADRLAAMGELLPGVDLVA--GLVAPPE 63 Query: 72 DYALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXXXX 131 LVVTSPG+ GV + G+VELAWR+ A P WLVV Sbjct: 64 GVDLVVTSPGWRPDNPLLAASAAAGVEVIGEVELAWRM--AAELADPPAWLVVTGTNGKT 121 Query: 132 XXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLRPEAGVV 191 +ML +L A G ++ CGN+G PV+ L +LAVELSSFQLHW+PS+RP AGV+ Sbjct: 122 TTVTMLESILRAAGLDAIACGNVGLPVVDALLAGHRVLAVELSSFQLHWSPSVRPTAGVL 181 Query: 192 LNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLGDPA 251 LNVAEDHLDWHGS+ AYAR KA L G VA+ G+DDP A LL + T VG LG+P Sbjct: 182 LNVAEDHLDWHGSLEAYARAKAGALVGDVAIAGVDDPYVAALLTGSPGTAHVGITLGEPE 241 Query: 252 AGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXXXXXX 311 G+LGV G L+DRAF LA AD+ GP Sbjct: 242 EGQLGVAGGYLVDRAFGPDSRLAAVADVTPGGPPGIADALAAAALARAYGVAPEAVRQGL 301 Query: 312 XSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVDELV 371 F+ G HR VVG V GV +++DSKATNPHAA AS+ +++ VVW+AGGLLKGASV +LV Sbjct: 302 LDFRPGDHRGVVVGEVGGVRYVNDSKATNPHAAVASLRSHESVVWIAGGLLKGASVADLV 361 Query: 372 RQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGDHVTR 431 R A+RL AVLIG DR +A AL+ HAP VPVVEL G +G + Sbjct: 362 RAEAHRLRAAVLIGADRAAIAAALAEHAPAVPVVELAEGGMAGAV--------------- 406 Query: 432 VIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 A PGD VLLAPA AS D F+ Y RG Sbjct: 407 ------------------RAAAGFARPGDAVLLAPAAASMDMFADYAHRG 438 >tr|D5YRL3|D5YRL3_MYCTU Tax_Id=515616 SubName: Full=UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;[Mycobacterium tuberculosis 02_1987] Length = 344 Score = 306 bits (784), Expect = 4e-81 Identities = 170/310 (54%), Positives = 199/310 (64%), Gaps = 2/310 (0%) Query: 174 SSFQLHW-APSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAG 232 SSFQLHW A + P N+AEDHLDWH +MA Y KARVL G VAV GLDD AA Sbjct: 25 SSFQLHWGAVAAGPRPARCSNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAA 84 Query: 233 LLPTAAATVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXX 292 LL + A VRVGFRLG+PAAGELGVRD L+DRAF D + L A I V GP+ Sbjct: 85 LLDGSPAQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALA 144 Query: 293 XXXXXXXXXXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYD 352 SF+VGRHRAEVV DG+ ++DDSKATNPHAA+AS+ AY Sbjct: 145 AAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYP 204 Query: 353 RVVWVAGGLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGED 412 RVVW+AGGLLKGAS+ V +A+RL GAVLIGRDR VA+ALSRHAPDVPVV++VAGED Sbjct: 205 RVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGED 264 Query: 413 SGVLGTNESIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFD 472 +G+ T E + V + + G R +A PGDTVLLAPAGASFD Sbjct: 265 TGMPATVEVPVACVLDVAK-DDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFD 323 Query: 473 QFSGYGQRGD 482 QF+GY RG+ Sbjct: 324 QFTGYADRGE 333 >tr|C8XGY8|C8XGY8_NAKMY Tax_Id=479431 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase;[Nakamurella multipartita] Length = 485 Score = 305 bits (782), Expect = 7e-81 Identities = 201/483 (41%), Positives = 242/483 (50%), Gaps = 45/483 (9%) Query: 13 PGARVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIASIGD 72 PG V+ GAG+TG V+ LA V G A GD Sbjct: 14 PGDLVVAAGAGVTGLPVVRYLAARGVRVVVTANRAAPAELAAIAGDVTFA-GDLATPPAG 72 Query: 73 YALVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYG---PPRRWLVVXXXXX 129 LV+TS G G+ + G+VELAWR+D G G PR WLVV Sbjct: 73 TTLVITSAGIPPTNPLLVAAAAAGIEVIGEVELAWRIDHDGPAGGQTAPRPWLVVTGTNG 132 Query: 130 XXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVL---------DQPAE-LLAVELSSFQLH 179 ML +L A GR CGNIG PVLA + D P + ++AVELSSFQLH Sbjct: 133 KTTTTGMLESILRAAGRTVTACGNIGWPVLAAVLAGGRDALDDTPRQDVIAVELSSFQLH 192 Query: 180 WAPSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAA 239 WAPSLRP AGVVLN+AEDHLDWHGSMAAY DKAR L G +A+ +DD AAGLL A A Sbjct: 193 WAPSLRPRAGVVLNLAEDHLDWHGSMAAYGADKARALAGEIALAVVDDSGAAGLLAGAGA 252 Query: 240 TVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVE-LADCADIGVAGPIXXXXXXXXXXXXX 298 R+ P AG LG+ DG L+D A+ + LA + G Sbjct: 253 PRRIPITAAAPVAGRLGLADGWLVDHAYAASAQRLAAAEAVRPPGAHNLTNALAAAGLAL 312 Query: 299 XXXXXXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVA 358 +F G HR +V GV ++DDSKATNPHAA AS+ AY RVVW+A Sbjct: 313 AAGVPAQAVATGLAAFAPGGHRNVLVTQRAGVRYVDDSKATNPHAALASLLAYPRVVWIA 372 Query: 359 GGLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGT 418 GG LKGA VDELV V +RLAG VL+G D ++ A+SRHAPDVPV+ + +D Sbjct: 373 GGQLKGAQVDELVLAVRDRLAGVVLLGVDAPVIHAAVSRHAPDVPVLPVPGTDD------ 426 Query: 419 NESIESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYG 478 D + V+ R +A+PGD VLLAPA AS D FS Y Sbjct: 427 --------DVMRSVVCAAAR----------------MAAPGDVVLLAPAAASLDMFSSYA 462 Query: 479 QRG 481 RG Sbjct: 463 ARG 465 >tr|A4QFM5|A4QFM5_CORGB Tax_Id=340322 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium glutamicum] Length = 472 Score = 305 bits (780), Expect = 1e-80 Identities = 181/470 (38%), Positives = 239/470 (50%), Gaps = 32/470 (6%) Query: 16 RVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXK-GVAVIAPGDAIASIGDYA 74 R+LV GAG++G ++ L+ L VA I+ A + ++ Sbjct: 14 RILVAGAGVSGLSIAKMLSELHCDVVVADDNETARHMLIEVVDVADISTAQAQEQLDSFS 73 Query: 75 LVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXXXXXXX 134 +VVTSPG+ G+ + GDVELAWRLD AG +G P WL V Sbjct: 74 IVVTSPGWRPTSTLLVDAHRQGLEVIGDVELAWRLDQAGVFGEPHTWLAVTGTNGKTTTT 133 Query: 135 SMLHDMLVAGGRRSVLCGNIGDPVLAVL--DQPAELLAVELSSFQLHWAPSLRPEAGVVL 192 SML M+ GG + GNIG PV L ++L ELSSFQLHW+P+ P+AGVVL Sbjct: 134 SMLAAMMNEGGFAAKAVGNIGIPVSEALVAKNRIDVLVAELSSFQLHWSPTFTPDAGVVL 193 Query: 193 NVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLGDPAA 252 N+AEDH+DWHGSM YA K VL G+VA++G DDP L A + +GF + +PA Sbjct: 194 NLAEDHIDWHGSMRDYALAKMEVLKGKVAIIGADDPYLVQLTSEADLSGLIGFTVNEPAT 253 Query: 253 GELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXXXXXXX 312 G+LGV+ G+L+D A+ + V LA I AGP Sbjct: 254 GQLGVKAGELVDNAYGNNVVLASADGINPAGPAGVLDALAAAAVARSQGVAPEAIARALD 313 Query: 313 SFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVDELVR 372 SF+V HR +VV DGV FID+SKATNPHAA +++ +D V+WV GG LKGA + LV+ Sbjct: 314 SFEVAGHRGQVVAEHDGVHFIDNSKATNPHAADSALAGHDSVIWVVGGQLKGADIAPLVK 373 Query: 373 QVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGDHVTRV 432 + R+ A+++G DR + AL HAP V V E E++ + VT Sbjct: 374 KHEQRIKAALVLGADRAEIVAALKEHAPQASVF---------VTDKTEPFEAMEEIVTEA 424 Query: 433 IEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 + + PGDTVLLAPA AS D F G GQRGD Sbjct: 425 FSI--------------------SEPGDTVLLAPAAASLDMFKGMGQRGD 454 >tr|Q6M3S0|Q6M3S0_CORGL Tax_Id=1718 (murD)SubName: Full=UDP-N-ACETYLMURAMOYLALANINE D-GLUTAMATE LIGASE; EC=6.3.2.9;[Corynebacterium glutamicum] Length = 472 Score = 301 bits (772), Expect = 1e-79 Identities = 180/470 (38%), Positives = 238/470 (50%), Gaps = 32/470 (6%) Query: 16 RVLVTGAGITGRAVLGALAPLEVXXXXXXXXXXXXXXXXXK-GVAVIAPGDAIASIGDYA 74 R+LV GAG++G ++ L+ L VA I+ A + ++ Sbjct: 14 RILVAGAGVSGLSIAKMLSELHCDVVVADDNETARHMLIEVVDVADISTAQAQEQLDSFS 73 Query: 75 LVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLDAAGRYGPPRRWLVVXXXXXXXXXX 134 +VVTSPG+ G+ + GDVELAWRLD AG +G P WL V Sbjct: 74 IVVTSPGWRPTSTLLVDAHRQGLEVIGDVELAWRLDQAGVFGEPHTWLAVTGTNGKTTTT 133 Query: 135 SMLHDMLVAGGRRSVLCGNIGDPVLAVL--DQPAELLAVELSSFQLHWAPSLRPEAGVVL 192 SML M+ GG + GNIG PV L ++L ELSSFQLHW+P+ P+AGVVL Sbjct: 134 SMLAAMMNEGGFTAKAVGNIGIPVSEALVAKNRIDVLVAELSSFQLHWSPTFTPDAGVVL 193 Query: 193 NVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAATVRVGFRLGDPAA 252 N+AEDH+DWHGSM YA K VL G+VA++G DDP L A + +GF + +PA Sbjct: 194 NLAEDHIDWHGSMRDYALAKMEVLKGKVAIIGADDPYLVQLTSEADLSGLIGFTVNEPAT 253 Query: 253 GELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXXXXXXXXXXXX 312 G+LGV+ G+L+D A+ + V LA I AGP Sbjct: 254 GQLGVKAGELVDNAYGNNVVLASADGINPAGPAGVLDALAAAAVARSQGVAPEAIARALD 313 Query: 313 SFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLLKGASVDELVR 372 SF+V HR +VV DGV FID+SKATNPHAA +++ +D V+WV GG LKGA + LV+ Sbjct: 314 SFEVAGHRGQVVAEHDGVHFIDNSKATNPHAADSALAGHDSVIWVVGGQLKGADIAPLVK 373 Query: 373 QVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESIESVGDHVTRV 432 + R+ A+++G DR + AL HA V V E E++ + VT Sbjct: 374 KHEQRIKAALVLGADRAEIVAALKEHASQASVF---------VTDKTEPFEAMEEIVTEA 424 Query: 433 IEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRGD 482 + + PGDTVLLAPA AS D F G GQRGD Sbjct: 425 FSI--------------------SEPGDTVLLAPAAASLDMFKGMGQRGD 454 >tr|A4FLW2|A4FLW2_SACEN Tax_Id=405948 (murD)SubName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Saccharopolyspora erythraea] Length = 469 Score = 301 bits (771), Expect = 1e-79 Identities = 199/479 (41%), Positives = 243/479 (50%), Gaps = 45/479 (9%) Query: 17 VLVTGAGITGRAVLGAL--APLEVXXXXXXXXXXXXXXXXXKGVAVIAPGDAIASIGDYA 74 +LV GAG++GR+ AL A V A + PG G Sbjct: 1 MLVAGAGVSGRSAAEALLAAGASVTVSDASSDRLVALASLQAQGAELVPGLTEPPEGT-D 59 Query: 75 LVVTSPGFXXXXXXXXXXXXXGVPIWGDVELAWRLD---------AAGRYGPPRRWLVVX 125 LVVTSPG+ GV + G+VELAWRLD + GR P WL V Sbjct: 60 LVVTSPGWRPESPLLAATVAAGVELIGEVELAWRLDQEKANEPADSTGRPAGPATWLAVT 119 Query: 126 XXXXXXXXXSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLHWAPSLR 185 ML +L A G V CGN+G PV+ + +LAVELSSFQLHW+ ++ Sbjct: 120 GTNGKTTTVGMLESILRADGVDVVACGNVGLPVVDAVRAGHRVLAVELSSFQLHWSQTVA 179 Query: 186 PEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGR-VAVVGLDDPVAAGLLPTAAATV--R 242 P A VVLN+A DHLDWHGS+ AY KARV G VAV DD + L A R Sbjct: 180 PHASVVLNLAADHLDWHGSLDAYGAAKARVYAGNSVAVHNADDEWSVRLADAGAPQQARR 239 Query: 243 VGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIXXXXXXXXXXXXXXXXX 302 V F L DPA G LGV G L+DRAF D V LA AD+ AGP Sbjct: 240 VSFTLSDPAPGVLGVESGALVDRAFGDRVRLAAVADVHPAGPHNVANALAAASLARAYGV 299 Query: 303 XXXXXXXXXXSFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAGGLL 362 SFQ G HR+ VV GV ++DDSKATNPHAA A++ A+ +VVW+AGGLL Sbjct: 300 EPEAVAEGLRSFQPGAHRSVVVAESAGVSYVDDSKATNPHAADAALRAHPKVVWIAGGLL 359 Query: 363 KGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTNESI 422 KGA V++LV A RLAG VLIGRDR A+AL+RHAPDVPV E+ +G+D+G+L Sbjct: 360 KGADVEDLVAANAARLAGVVLIGRDRARFAEALARHAPDVPVREVESGDDAGMLA----- 414 Query: 423 ESVGDHVTRVIEVGGRPXXXXXXXXXXXXXRDLASPGDTVLLAPAGASFDQFSGYGQRG 481 + + G + A PG V+LAPA AS D F+ Y RG Sbjct: 415 ---------AVRLAG----------------EFAEPGCAVVLAPAAASMDMFTDYAHRG 448 Database: Amellifera_nr Posted date: Jul 23, 2010 5:10 AM Number of letters in database: 4,236,830,644 Number of sequences in database: 12,507,864 Lambda K H 0.319 0.139 0.415 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 12507864 Number of Hits to DB: 3,443,668,148 Number of extensions: 126185345 Number of successful extensions: 345680 Number of sequences better than 10.0: 3113 Number of HSP's gapped: 343889 Number of HSP's successfully gapped: 4727 Length of query: 493 Length of database: 4,236,830,644 Length adjustment: 142 Effective length of query: 351 Effective length of database: 2,460,713,956 Effective search space: 863710598556 Effective search space used: 863710598556 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 83 (36.6 bits)