BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MSMEG_6250 (423 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 12,507,864 sequences; 4,236,830,644 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|A0R5N1|A0R5N1_MYCS2 Tax_Id=246196 SubName: Full=Glutamate--cy... 724 0.0 tr|Q1B298|Q1B298_MYCSS Tax_Id=164756 SubName: Full=Glutamate--cy... 533 e-149 tr|A3Q786|A3Q786_MYCSJ Tax_Id=164757 SubName: Full=Glutamate--cy... 533 e-149 tr|A1UMV2|A1UMV2_MYCSK Tax_Id=189918 SubName: Full=Glutamate--cy... 533 e-149 tr|A4T5Z6|A4T5Z6_MYCGI Tax_Id=350054 SubName: Full=Glutamate--cy... 529 e-148 tr|A1TGF5|A1TGF5_MYCVP Tax_Id=350058 SubName: Full=Glutamate--cy... 521 e-146 tr|Q744N5|Q744N5_MYCPA Tax_Id=1770 (gshA)SubName: Full=GshA;[Myc... 499 e-139 tr|A0Q9U6|A0Q9U6_MYCA1 Tax_Id=243243 SubName: Full=Putative glut... 499 e-139 tr|B2HKC3|B2HKC3_MYCMM Tax_Id=216594 (gshA)SubName: Full=Glutama... 484 e-135 tr|D5P910|D5P910_9MYCO Tax_Id=525368 SubName: Full=Probable glut... 475 e-132 tr|Q7TVW1|Q7TVW1_MYCBO Tax_Id=1765 (gshA)SubName: Full=GLUTAMATE... 473 e-131 tr|O69672|O69672_MYCTU Tax_Id=1773 (gshA)SubName: Full=GLUTAMATE... 473 e-131 tr|C6DNE3|C6DNE3_MYCTK Tax_Id=478434 SubName: Full=Glutamate-cys... 473 e-131 tr|C1AIF7|C1AIF7_MYCBT Tax_Id=561275 (gshA)SubName: Full=Glutama... 473 e-131 tr|A5U929|A5U929_MYCTA Tax_Id=419947 (gshA)SubName: Full=Putativ... 473 e-131 tr|A1KQ35|A1KQ35_MYCBP Tax_Id=410289 (gshA)SubName: Full=Glutama... 473 e-131 tr|D6G5H9|D6G5H9_MYCTU Tax_Id=478435 SubName: Full=Glutamate-cys... 473 e-131 tr|D6FAQ7|D6FAQ7_MYCTU Tax_Id=611303 SubName: Full=Glutamate-cys... 473 e-131 tr|D6EZ56|D6EZ56_MYCTU Tax_Id=611302 SubName: Full=Glutamate-cys... 473 e-131 tr|D5ZMP9|D5ZMP9_MYCTU Tax_Id=537210 SubName: Full=Glutamate-cys... 473 e-131 tr|D5YXX6|D5YXX6_MYCTU Tax_Id=515616 SubName: Full=Glutamate-cys... 473 e-131 tr|D5YLF2|D5YLF2_MYCTU Tax_Id=520140 SubName: Full=Glutamate-cys... 473 e-131 tr|A4KMH1|A4KMH1_MYCTU Tax_Id=395095 SubName: Full=Glutamate-cys... 473 e-131 tr|A2VM86|A2VM86_MYCTU Tax_Id=348776 SubName: Full=Glutamate-cys... 473 e-131 tr|D6FTW8|D6FTW8_MYCTU Tax_Id=611304 SubName: Full=Glutamate-cys... 473 e-131 tr|A5WTS1|A5WTS1_MYCTF Tax_Id=336982 SubName: Full=Glutamate-cys... 471 e-131 tr|D2S3Y3|D2S3Y3_GEOOG Tax_Id=526225 SubName: Full=Glutamate/cys... 380 e-103 tr|D5ZAS8|D5ZAS8_MYCTU Tax_Id=537209 SubName: Full=Glutamate-cys... 359 4e-97 tr|D5Y9V3|D5Y9V3_MYCTU Tax_Id=520141 SubName: Full=Glutamate-cys... 336 4e-90 tr|B1MFR8|B1MFR8_MYCA9 Tax_Id=561007 SubName: Full=Glutamate--cy... 332 5e-89 tr|D5XNK6|D5XNK6_MYCTU Tax_Id=515617 SubName: Full=Glutamate-cys... 280 2e-73 tr|D3LZ15|D3LZ15_9ACTO Tax_Id=656024 SubName: Full=Glutamate/cys... 275 9e-72 tr|D1VG95|D1VG95_9ACTO Tax_Id=298654 SubName: Full=Glutamate/cys... 260 3e-67 tr|A8L8S2|A8L8S2_FRASN Tax_Id=298653 SubName: Full=Glutamate--cy... 226 4e-57 tr|D3D6J4|D3D6J4_9ACTO Tax_Id=102897 SubName: Full=Glutamate/cys... 225 8e-57 tr|Q0RAS7|Q0RAS7_FRAAA Tax_Id=326424 (gshA)SubName: Full=Glutama... 221 2e-55 tr|Q2J4D5|Q2J4D5_FRASC Tax_Id=106370 SubName: Full=Glutamate--cy... 216 6e-54 tr|D1ACB6|D1ACB6_THECD Tax_Id=471852 SubName: Full=Glutamate/cys... 214 2e-53 tr|C1YNM4|C1YNM4_NOCDA Tax_Id=446468 SubName: Full=Glutamate--cy... 212 7e-53 tr|C8XBM8|C8XBM8_NAKMY Tax_Id=479431 SubName: Full=Glutamate/cys... 210 3e-52 tr|D2B0V7|D2B0V7_STRRD Tax_Id=479432 SubName: Full=Glutamate/cys... 210 3e-52 tr|C6WGZ9|C6WGZ9_ACTMD Tax_Id=446462 SubName: Full=Glutamate--cy... 203 4e-50 tr|B5I149|B5I149_9ACTO Tax_Id=463191 SubName: Full=Putative unch... 192 6e-47 tr|D5XNK5|D5XNK5_MYCTU Tax_Id=515617 SubName: Full=Glutamate-cys... 192 1e-46 tr|D1XI92|D1XI92_9ACTO Tax_Id=647653 SubName: Full=Glutamate/cys... 189 8e-46 >tr|A0R5N1|A0R5N1_MYCS2 Tax_Id=246196 SubName: Full=Glutamate--cysteine ligase; EC=6.3.2.2;[Mycobacterium smegmatis] Length = 423 Score = 724 bits (1868), Expect = 0.0 Identities = 364/423 (86%), Positives = 364/423 (86%) Query: 1 MALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSW 60 MALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSW Sbjct: 1 MALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSW 60 Query: 61 DELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNL 120 DELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGP EFARRNL Sbjct: 61 DELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPLAAVAALQADRAVLRAEFARRNL 120 Query: 121 GLVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGW 180 GLVLLGTDPLRPTRRVNPGARYSAMEQFF VQVNLDAGPRDGW Sbjct: 121 GLVLLGTDPLRPTRRVNPGARYSAMEQFFTASGTAEAGAAMMTATASVQVNLDAGPRDGW 180 Query: 181 AERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPAS 240 AERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPAS Sbjct: 181 AERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPAS 240 Query: 241 EWARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVR 300 EWARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVR Sbjct: 241 EWARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVR 300 Query: 301 PRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDR 360 PRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDR Sbjct: 301 PRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDR 360 Query: 361 HLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSDXXXXXXXXXXXXELAK 420 HLHTAALTCV SMTLLMRSVQQRRSPADDFSD ELAK Sbjct: 361 HLHTAALTCVRLAAERAPAELEESMTLLMRSVQQRRSPADDFSDRVVARGIAAAVRELAK 420 Query: 421 GEL 423 GEL Sbjct: 421 GEL 423 >tr|Q1B298|Q1B298_MYCSS Tax_Id=164756 SubName: Full=Glutamate--cysteine ligase, GCS2;[Mycobacterium sp.] Length = 424 Score = 533 bits (1373), Expect = e-149 Identities = 267/423 (63%), Positives = 304/423 (71%), Gaps = 1/423 (0%) Query: 1 MALPARSDSGC-AVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPS 59 M +P D GC P EF SA AA HI + L DGP+G+VGLE+EAH FDL++P RRP Sbjct: 1 MTVPTTYDPGCDTAPDEFASAADAAEHITEHCLHDGPVGQVGLEVEAHSFDLADPRRRPD 60 Query: 60 WDELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRN 119 W E++ IA V LPGGSRITVEPGGAVELSGPP DG FA+R Sbjct: 61 WGEVTDAIAGVGALPGGSRITVEPGGAVELSGPPADGSVAAIAAMTSDRAVLRTAFAQRG 120 Query: 120 LGLVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDG 179 LGLVL+G DPLR RRVNPG RYSAME FF +Q+NLDAGPR G Sbjct: 121 LGLVLVGADPLRRPRRVNPGGRYSAMEAFFTASGTGAAGAFMMTSTASIQLNLDAGPRRG 180 Query: 180 WAERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPA 239 WA+RVRLAHALGPTMIA TANSP+L G+F+GW S+RQ VWG+LD ARCGPVLG GDDPA Sbjct: 181 WADRVRLAHALGPTMIAATANSPLLAGRFSGWQSSRQWVWGELDEARCGPVLGASGDDPA 240 Query: 240 SEWARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPV 299 S+WARYALRAPVMLV++P+ VPVT+WVPFA+WADG+ +LGGRRPT +DL+YHLTTLFPPV Sbjct: 241 SDWARYALRAPVMLVHNPEPVPVTDWVPFAEWADGQTLLGGRRPTRSDLEYHLTTLFPPV 300 Query: 300 RPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTD 359 RPRRWLEIRYLD+V DALWPA FTLTTLLDDP AA+ AAEAT VATAWDRAAR+GL D Sbjct: 301 RPRRWLEIRYLDAVSDALWPAVAFTLTTLLDDPAAADIAAEATESVATAWDRAARIGLGD 360 Query: 360 RHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSDXXXXXXXXXXXXELA 419 R LH AAL CV SM L+RSV++ RSPADDF+D +LA Sbjct: 361 RRLHAAALRCVETAAERAPAAVMESMQQLVRSVEEGRSPADDFADRAVAYGIGPAVRQLA 420 Query: 420 KGE 422 KGE Sbjct: 421 KGE 423 >tr|A3Q786|A3Q786_MYCSJ Tax_Id=164757 SubName: Full=Glutamate--cysteine ligase, GCS2;[Mycobacterium sp.] Length = 424 Score = 533 bits (1373), Expect = e-149 Identities = 267/423 (63%), Positives = 304/423 (71%), Gaps = 1/423 (0%) Query: 1 MALPARSDSGC-AVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPS 59 M +P D GC P EF SA AA HI + L DGP+G+VGLE+EAH FDL++P RRP Sbjct: 1 MTVPTTYDPGCDTAPDEFASAADAAEHITEHCLHDGPVGQVGLEVEAHSFDLADPRRRPD 60 Query: 60 WDELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRN 119 W E++ IA V LPGGSRITVEPGGAVELSGPP DG FA+R Sbjct: 61 WGEVTDAIAGVGALPGGSRITVEPGGAVELSGPPADGSVAAIAAMTSDRAVLRTAFAQRG 120 Query: 120 LGLVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDG 179 LGLVL+G DPLR RRVNPG RYSAME FF +Q+NLDAGPR G Sbjct: 121 LGLVLVGADPLRRPRRVNPGGRYSAMEAFFTASGTGAAGAFMMTSTASIQLNLDAGPRRG 180 Query: 180 WAERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPA 239 WA+RVRLAHALGPTMIA TANSP+L G+F+GW S+RQ VWG+LD ARCGPVLG GDDPA Sbjct: 181 WADRVRLAHALGPTMIAATANSPLLAGRFSGWQSSRQWVWGELDEARCGPVLGASGDDPA 240 Query: 240 SEWARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPV 299 S+WARYALRAPVMLV++P+ VPVT+WVPFA+WADG+ +LGGRRPT +DL+YHLTTLFPPV Sbjct: 241 SDWARYALRAPVMLVHNPEPVPVTDWVPFAEWADGQTLLGGRRPTRSDLEYHLTTLFPPV 300 Query: 300 RPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTD 359 RPRRWLEIRYLD+V DALWPA FTLTTLLDDP AA+ AAEAT VATAWDRAAR+GL D Sbjct: 301 RPRRWLEIRYLDAVSDALWPAVAFTLTTLLDDPAAADIAAEATESVATAWDRAARIGLGD 360 Query: 360 RHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSDXXXXXXXXXXXXELA 419 R LH AAL CV SM L+RSV++ RSPADDF+D +LA Sbjct: 361 RRLHAAALRCVETAAERAPAAVMESMQQLVRSVEEGRSPADDFADRAVAYGIGPAVRQLA 420 Query: 420 KGE 422 KGE Sbjct: 421 KGE 423 >tr|A1UMV2|A1UMV2_MYCSK Tax_Id=189918 SubName: Full=Glutamate--cysteine ligase, GCS2;[Mycobacterium sp.] Length = 424 Score = 533 bits (1373), Expect = e-149 Identities = 267/423 (63%), Positives = 304/423 (71%), Gaps = 1/423 (0%) Query: 1 MALPARSDSGC-AVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPS 59 M +P D GC P EF SA AA HI + L DGP+G+VGLE+EAH FDL++P RRP Sbjct: 1 MTVPTTYDPGCDTAPDEFASAADAAEHITEHCLHDGPVGQVGLEVEAHSFDLADPRRRPD 60 Query: 60 WDELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRN 119 W E++ IA V LPGGSRITVEPGGAVELSGPP DG FA+R Sbjct: 61 WGEVTDAIAGVGALPGGSRITVEPGGAVELSGPPADGSVAAIAAMTSDRAVLRTAFAQRG 120 Query: 120 LGLVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDG 179 LGLVL+G DPLR RRVNPG RYSAME FF +Q+NLDAGPR G Sbjct: 121 LGLVLVGADPLRRPRRVNPGGRYSAMEAFFTASGTGAAGAFMMTSTASIQLNLDAGPRRG 180 Query: 180 WAERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPA 239 WA+RVRLAHALGPTMIA TANSP+L G+F+GW S+RQ VWG+LD ARCGPVLG GDDPA Sbjct: 181 WADRVRLAHALGPTMIAATANSPLLAGRFSGWQSSRQWVWGELDEARCGPVLGASGDDPA 240 Query: 240 SEWARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPV 299 S+WARYALRAPVMLV++P+ VPVT+WVPFA+WADG+ +LGGRRPT +DL+YHLTTLFPPV Sbjct: 241 SDWARYALRAPVMLVHNPEPVPVTDWVPFAEWADGQTLLGGRRPTRSDLEYHLTTLFPPV 300 Query: 300 RPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTD 359 RPRRWLEIRYLD+V DALWPA FTLTTLLDDP AA+ AAEAT VATAWDRAAR+GL D Sbjct: 301 RPRRWLEIRYLDAVSDALWPAVAFTLTTLLDDPAAADIAAEATESVATAWDRAARIGLGD 360 Query: 360 RHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSDXXXXXXXXXXXXELA 419 R LH AAL CV SM L+RSV++ RSPADDF+D +LA Sbjct: 361 RRLHAAALRCVETAAERAPAAVMESMQQLVRSVEEGRSPADDFADRAVAYGIGPAVRQLA 420 Query: 420 KGE 422 KGE Sbjct: 421 KGE 423 >tr|A4T5Z6|A4T5Z6_MYCGI Tax_Id=350054 SubName: Full=Glutamate--cysteine ligase, GCS2;[Mycobacterium gilvum] Length = 448 Score = 529 bits (1363), Expect = e-148 Identities = 268/409 (65%), Positives = 301/409 (73%) Query: 15 VEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLP 74 V TSAE AA HI L+D P G VGLEIEAHC+DLS+P RRP WDEL+AVIAD+P LP Sbjct: 40 VPLTSAEDAAQHIVDTCLKDVPPGPVGLEIEAHCYDLSDPFRRPGWDELTAVIADLPRLP 99 Query: 75 GGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTR 134 GGS +TVEPGGAVELSGPP G FA LGLVLLG DPLRP Sbjct: 100 GGSLVTVEPGGAVELSGPPATGTADAVSAMVTDRAVLRDVFAGAGLGLVLLGADPLRPAG 159 Query: 135 RVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTM 194 RVNPG+RY+AME+FF VQVNL+AG R GWA+RVRLAHALGPTM Sbjct: 160 RVNPGSRYAAMERFFAESGTPEAGAAMMTSTASVQVNLEAGHRAGWADRVRLAHALGPTM 219 Query: 195 IAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEWARYALRAPVMLV 254 IAI ANSP+L G+FTGW STRQ VW QLDSARCGP+LGVDGDDPAS+WARYALRAPVMLV Sbjct: 220 IAIAANSPVLAGKFTGWHSTRQLVWSQLDSARCGPILGVDGDDPASDWARYALRAPVMLV 279 Query: 255 NSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVP 314 ++P+AVPVT WVPFADWADGR +L RRPT ADLDYHLTTLFPPVRPR +LE+RYLDSVP Sbjct: 280 HTPEAVPVTQWVPFADWADGRVLLDDRRPTLADLDYHLTTLFPPVRPRGFLEVRYLDSVP 339 Query: 315 DALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVXXXX 374 DA+WPA VFTL+TLLDDPVAA+ AAEAT PVAT+WDRAA++GL DR LHTAA+ CV Sbjct: 340 DAVWPAVVFTLSTLLDDPVAADVAAEATEPVATSWDRAAQLGLDDRRLHTAAVRCVYAAA 399 Query: 375 XXXXXXXXXSMTLLMRSVQQRRSPADDFSDXXXXXXXXXXXXELAKGEL 423 SM LL RSV+Q RSP DDF+D LA+G++ Sbjct: 400 DRAPAALVESMELLTRSVEQGRSPGDDFADRVVNDGIAAAVTRLAQGDM 448 >tr|A1TGF5|A1TGF5_MYCVP Tax_Id=350058 SubName: Full=Glutamate--cysteine ligase, GCS2;[Mycobacterium vanbaalenii] Length = 424 Score = 521 bits (1341), Expect = e-146 Identities = 262/406 (64%), Positives = 291/406 (71%) Query: 18 TSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLPGGS 77 +SAE AA HI L DGP+G+VGLE+EAHCFDL++P+RRP WDEL+A I +PPLPGGS Sbjct: 19 SSAEAAAQHIVDGCLIDGPVGQVGLEVEAHCFDLTDPSRRPGWDELTATITALPPLPGGS 78 Query: 78 RITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVN 137 +TVEPGGAVELSGPP P FAR LGLVL+G DPLRP RVN Sbjct: 79 VVTVEPGGAVELSGPPLAEPASAISAMAADHTVLRAAFARAGLGLVLVGADPLRPAARVN 138 Query: 138 PGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTMIAI 197 PG RY AME FF VQVNL+AGPR GWA+RVRLAHALGPTMIAI Sbjct: 139 PGPRYQAMEAFFRASDSGDAGAAMMTSTASVQVNLEAGPRAGWADRVRLAHALGPTMIAI 198 Query: 198 TANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEWARYALRAPVMLVNSP 257 ANSP+LGG FTGW STRQ VW +LDSARCGP+LG GDDPAS+WARYALRAPVMLV+SP Sbjct: 199 AANSPVLGGDFTGWQSTRQLVWSRLDSARCGPILGASGDDPASDWARYALRAPVMLVHSP 258 Query: 258 DAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDAL 317 D PVT WVPFADWADGR +L R PT ADLDYHLTTLFPPVRPR +LE+RYLDSVPDA Sbjct: 259 DPTPVTQWVPFADWADGRVLLDDRPPTLADLDYHLTTLFPPVRPRGFLEVRYLDSVPDAT 318 Query: 318 WPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVXXXXXXX 377 WPA V+TL TLLDDP AA+ AAEAT VATAWDRAA++GL DR LH AA CV Sbjct: 319 WPAVVYTLATLLDDPAAADVAAEATEEVATAWDRAAQLGLRDRRLHAAATRCVQAAADRA 378 Query: 378 XXXXXXSMTLLMRSVQQRRSPADDFSDXXXXXXXXXXXXELAKGEL 423 SM L+RSV+Q RSPADDF+D ELA+GEL Sbjct: 379 PRALEESMGHLVRSVEQGRSPADDFADRVVAHGIADAVTELAQGEL 424 >tr|Q744N5|Q744N5_MYCPA Tax_Id=1770 (gshA)SubName: Full=GshA;[Mycobacterium paratuberculosis] Length = 436 Score = 499 bits (1285), Expect = e-139 Identities = 246/402 (61%), Positives = 282/402 (70%), Gaps = 1/402 (0%) Query: 4 PARSDSGCAVPV-EFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDE 62 PA D + + E T + A +I L D P+GRVGLE+EAHC D +P RRP WDE Sbjct: 13 PAGGDPAAELRIAELTDSAAVAQYIARGCLADAPLGRVGLEVEAHCHDPQDPCRRPGWDE 72 Query: 63 LSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGL 122 ++AV+ +P LPGGSR+TVEPGGAVELSGPP DG FA LGL Sbjct: 73 IAAVLDALPALPGGSRVTVEPGGAVELSGPPADGVLAAIDAMRRDQAVLRPAFAGAGLGL 132 Query: 123 VLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAE 182 V LG DPLRP +R+NPGARY AME+FF +QVN+DAGPR+GWA Sbjct: 133 VFLGADPLRPPQRINPGARYRAMERFFATSRSGEAGAAMMTSTASIQVNVDAGPREGWAA 192 Query: 183 RVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEW 242 RVRLAHALGPTMIA+TANSPML G FTGW S+RQRVWG++DSARCGPVLG GDDP ++W Sbjct: 193 RVRLAHALGPTMIAMTANSPMLDGDFTGWVSSRQRVWGRMDSARCGPVLGASGDDPGTDW 252 Query: 243 ARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPR 302 ARYAL+APVMLV++PDA VT WVPFADW DGR +LGGRRPT ADL+YHLTTLFPPVRPR Sbjct: 253 ARYALKAPVMLVHTPDAEAVTRWVPFADWVDGRVLLGGRRPTVADLEYHLTTLFPPVRPR 312 Query: 303 RWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHL 362 +WLEIRYLDSVPD LWPA VFTL LLDDPVAA AA A PVATAWD AAR+GL DR L Sbjct: 313 QWLEIRYLDSVPDTLWPAVVFTLVALLDDPVAAGLAARAVEPVATAWDVAARVGLRDRRL 372 Query: 363 HTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 + AA C+ M L+R V+Q R P DDF+D Sbjct: 373 YAAANACLAIAAERAPAELAEPMRRLVRLVEQGRCPGDDFAD 414 >tr|A0Q9U6|A0Q9U6_MYCA1 Tax_Id=243243 SubName: Full=Putative glutamate--cysteine ligase; EC=6.3.2.2;[Mycobacterium avium] Length = 436 Score = 499 bits (1285), Expect = e-139 Identities = 245/402 (60%), Positives = 282/402 (70%), Gaps = 1/402 (0%) Query: 4 PARSDSGCAVPV-EFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDE 62 PA D + + E T + A +I L D P+GRVGLE+EAHC D +P RRP WDE Sbjct: 13 PAGGDPAAELRIAELTDSAAVAHYIARGCLADAPLGRVGLEVEAHCHDPQDPCRRPGWDE 72 Query: 63 LSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGL 122 ++AV+ +P LPGGSR+TVEPGGAVELSGPP DG FA LGL Sbjct: 73 IAAVLDALPALPGGSRVTVEPGGAVELSGPPADGVLAAIDAMRRDQAVLRPAFAEAGLGL 132 Query: 123 VLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAE 182 V LG DPLRP +R+NPGARY AME+FF +QVN+DAGPR+GWA Sbjct: 133 VFLGADPLRPPQRINPGARYRAMERFFATSRSGEAGAAMMTSTASIQVNVDAGPREGWAA 192 Query: 183 RVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEW 242 RVRLAHALGPTMIA+TANSPML G FTGW S+RQRVWG++DSARCGP+LG GDDP ++W Sbjct: 193 RVRLAHALGPTMIAMTANSPMLDGDFTGWVSSRQRVWGRMDSARCGPILGASGDDPGTDW 252 Query: 243 ARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPR 302 ARYAL+APVMLV++PDA VT WVPFADW DGR +LGGRRPT ADL+YHLTTLFPPVRPR Sbjct: 253 ARYALKAPVMLVHTPDAEAVTRWVPFADWVDGRVLLGGRRPTVADLEYHLTTLFPPVRPR 312 Query: 303 RWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHL 362 +WLEIRYLDSVPD LWPA VFTL LLDDPVAA AA A PVATAWD AAR+GL DR L Sbjct: 313 QWLEIRYLDSVPDTLWPAVVFTLVALLDDPVAAGLAARAVEPVATAWDVAARVGLRDRRL 372 Query: 363 HTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 + AA C+ M L+R V+Q R P DDF+D Sbjct: 373 YAAANACLAIAAERAPAELAEPMRRLVRLVEQGRCPGDDFAD 414 >tr|B2HKC3|B2HKC3_MYCMM Tax_Id=216594 (gshA)SubName: Full=Glutamate--cysteine ligase GshA;[Mycobacterium marinum] Length = 429 Score = 484 bits (1247), Expect = e-135 Identities = 244/421 (57%), Positives = 280/421 (66%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ DS A + + AA +I L DGPIGRVGLEIEAHC+D ++P RRPSW+ Sbjct: 8 AATSQLDSSRAADADIAGSAVAAQYIANGCLVDGPIGRVGLEIEAHCYDPADPHRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E+ V+ + PGGS +TVEPGGAVELSGPP DG FA LG Sbjct: 68 EIGDVLEGLGKPPGGSAVTVEPGGAVELSGPPCDGILAAIDAMHRDQAVLRSAFADAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DP+RPT R+NPGARY AMEQFF +QVNLDAGP+ GWA Sbjct: 128 LVCLGADPIRPTMRINPGARYQAMEQFFTASQSGMAGAAMMTSTASIQVNLDAGPQSGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 RVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+D RCGP+LG DDPA++ Sbjct: 188 SRVRLAHALGPTMIAIAANSPMLGGEFSGWRSTRQRVWGQMDDGRCGPILGASADDPATD 247 Query: 242 WARYALRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRP 301 WA YAL+APVMLV++PDAV VT+ VPFADW DGR +LG RRPT ADLDYHLTTLFPPVRP Sbjct: 248 WAHYALKAPVMLVHNPDAVAVTHHVPFADWVDGRVLLGDRRPTYADLDYHLTTLFPPVRP 307 Query: 302 RRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRH 361 R+WLEIRYLDS+ D WPA VFTL TLLDDP AAE A EA +PVAT WD AAR GL D Sbjct: 308 RQWLEIRYLDSLSDVFWPAVVFTLVTLLDDPGAAELAFEAVQPVATEWDTAARAGLGDPR 367 Query: 362 LHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSDXXXXXXXXXXXXELAKG 421 LH AA CV ++ L+ VQ+ R P DDF D LA+G Sbjct: 368 LHAAASRCVAIAAERAPAELADALQSLLAYVQRGRCPGDDFGDQVTEHGVAPAIARLARG 427 Query: 422 E 422 E Sbjct: 428 E 428 >tr|D5P910|D5P910_9MYCO Tax_Id=525368 SubName: Full=Probable glutamate--cysteine ligase; EC=6.3.2.2; Flags: Fragment;[Mycobacterium parascrofulaceum ATCC BAA-614] Length = 363 Score = 475 bits (1223), Expect = e-132 Identities = 232/347 (66%), Positives = 256/347 (73%) Query: 16 EFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLPG 75 E ++ AA +I L D P+GRVGLE+EAHC D +P RRP WDE++ V+ +P LPG Sbjct: 17 EMADSQAAAGYIADGCLVDSPLGRVGLELEAHCHDPVDPHRRPGWDEIAGVLGSLPELPG 76 Query: 76 GSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRR 135 GSRITVEPGGAVELSGPP DG F LGLV LG DPLRP +R Sbjct: 77 GSRITVEPGGAVELSGPPADGVLAAIDAMRRDQAVLRSAFVDAGLGLVFLGADPLRPPKR 136 Query: 136 VNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTMI 195 +NPGARY AMEQFF +QVNLDAGPR GWA+RVRLAHALGPTMI Sbjct: 137 INPGARYRAMEQFFASSRSGEAGAAMMTSTASIQVNLDAGPRAGWADRVRLAHALGPTMI 196 Query: 196 AITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEWARYALRAPVMLVN 255 A+ ANSPML G FTGW STRQ VWGQ+DSARCGPVLGV GDDP ++WARYAL+APVMLV+ Sbjct: 197 AMAANSPMLCGGFTGWSSTRQWVWGQMDSARCGPVLGVSGDDPGTDWARYALKAPVMLVH 256 Query: 256 SPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPD 315 PDAV VT+WVPFADW DGR +LGGRRPT ADL+YHLTTLFPPVRPRRWLEIRYLDSVP+ Sbjct: 257 CPDAVAVTDWVPFADWVDGRVLLGGRRPTVADLEYHLTTLFPPVRPRRWLEIRYLDSVPE 316 Query: 316 ALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHL 362 WPA VFTL LLDDPVAA AAEA PVATAWD AAR GL DR L Sbjct: 317 DFWPALVFTLVALLDDPVAAGIAAEAVEPVATAWDTAARSGLRDRRL 363 >tr|Q7TVW1|Q7TVW1_MYCBO Tax_Id=1765 (gshA)SubName: Full=GLUTAMATE--CYSTEINE LIGASE GSHA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE); EC=6.3.2.2;[Mycobacterium bovis] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|O69672|O69672_MYCTU Tax_Id=1773 (gshA)SubName: Full=GLUTAMATE--CYSTEINE LIGASE GSHA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE); EC=6.3.2.2; SubName: Full=Glutamate--cysteine ligase, putative;[Mycobacterium tuberculosis] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|C6DNE3|C6DNE3_MYCTK Tax_Id=478434 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|C1AIF7|C1AIF7_MYCBT Tax_Id=561275 (gshA)SubName: Full=Glutamate--cysteine ligase GshA; EC=6.3.2.2;[Mycobacterium bovis] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|A5U929|A5U929_MYCTA Tax_Id=419947 (gshA)SubName: Full=Putative glutamate--cysteine ligase;[Mycobacterium tuberculosis] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|A1KQ35|A1KQ35_MYCBP Tax_Id=410289 (gshA)SubName: Full=Glutamate--cysteine ligase gshA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE); EC=6.3.2.2;[Mycobacterium bovis] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D6G5H9|D6G5H9_MYCTU Tax_Id=478435 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis KZN 605] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D6FAQ7|D6FAQ7_MYCTU Tax_Id=611303 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis CPHL_A] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D6EZ56|D6EZ56_MYCTU Tax_Id=611302 SubName: Full=Glutamate-cysteine ligase;[Mycobacterium tuberculosis T46] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D5ZMP9|D5ZMP9_MYCTU Tax_Id=537210 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis T17] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D5YXX6|D5YXX6_MYCTU Tax_Id=515616 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis 02_1987] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D5YLF2|D5YLF2_MYCTU Tax_Id=520140 SubName: Full=Glutamate-cysteine ligase gsha;[Mycobacterium tuberculosis EAS054] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|A4KMH1|A4KMH1_MYCTU Tax_Id=395095 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis str. Haarlem] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|A2VM86|A2VM86_MYCTU Tax_Id=348776 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis C] Length = 432 Score = 473 bits (1217), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D6FTW8|D6FTW8_MYCTU Tax_Id=611304 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis K85] Length = 432 Score = 473 bits (1216), Expect = e-131 Identities = 239/406 (58%), Positives = 279/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 ASASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|A5WTS1|A5WTS1_MYCTF Tax_Id=336982 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis] Length = 432 Score = 471 bits (1213), Expect = e-131 Identities = 238/406 (58%), Positives = 278/406 (68%), Gaps = 3/406 (0%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 8 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 67 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 68 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 127 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 128 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 187 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DS RCGP+LG GD P + Sbjct: 188 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSTRCGPILGASGDHPGID 247 Query: 242 WARYALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPP 298 WA+YAL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPP Sbjct: 248 WAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPP 307 Query: 299 VRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLT 358 VRPR+WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL Sbjct: 308 VRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLA 367 Query: 359 DRHLHTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 DR L+ AA C+ +M L+ V + PADDFSD Sbjct: 368 DRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 413 >tr|D2S3Y3|D2S3Y3_GEOOG Tax_Id=526225 SubName: Full=Glutamate/cysteine ligase family protein;[Geodermatophilus obscurus] Length = 418 Score = 380 bits (976), Expect = e-103 Identities = 199/387 (51%), Positives = 233/387 (60%), Gaps = 5/387 (1%) Query: 21 EQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLPGGSRIT 80 + AAAH+ +L+ GP+G VGLE+EAH DL+ P R W ++ ++ +P LPGGSR+T Sbjct: 15 DAAAAHVAGAALRAGPVGSVGLELEAHLVDLAAPATRVPWQRITGIVDALPALPGGSRVT 74 Query: 81 VEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVNPGA 140 +EPGG VELSGPPY L + +G DPLRP RV P Sbjct: 75 LEPGGQVELSGPPYPDVAAAVAALRADRDVLAAALVAERLAVAPVGADPLRPPARVCPAP 134 Query: 141 RYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTMIAITAN 200 RY+AME+ F +QVNLDAGP GW+ERV LAH LGPT++A+ A Sbjct: 135 RYAAMEEHFAAVGCAEAGTAMMAGTAALQVNLDAGPCAGWSERVSLAHQLGPTLVAVAAC 194 Query: 201 SPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEWARYALRAPVMLVNSPD-- 258 SP+ GG+ TGW S RQRVW LD ARCGP+LG G DPA EWA YAL APVMLV+ PD Sbjct: 195 SPLAGGRPTGWVSQRQRVWSDLDQARCGPLLG--GADPAGEWAAYALAAPVMLVSDPDGG 252 Query: 259 -AVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDAL 317 A PV V FADW G LGGR PT ADLDYHLTTLFPPVRPR +LEIRYLD+ P+ Sbjct: 253 GAAPVRERVRFADWVTGAVPLGGRAPTAADLDYHLTTLFPPVRPRGYLEIRYLDAAPEPW 312 Query: 318 WPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVXXXXXXX 377 WPA LLDDPVAA AA AT PVA AWDRAAR+GL D LHTAA TC+ Sbjct: 313 WPALAAVTAVLLDDPVAAGHAAAATAPVAGAWDRAARVGLADPALHTAARTCLAAACAAV 372 Query: 378 XXXXXXSMTLLMRSVQQRRSPADDFSD 404 + L V + R P D D Sbjct: 373 PVALRPEVEALADLVDRGRCPGDALLD 399 >tr|D5ZAS8|D5ZAS8_MYCTU Tax_Id=537209 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis GM 1503] Length = 311 Score = 359 bits (922), Expect = 4e-97 Identities = 179/282 (63%), Positives = 203/282 (71%), Gaps = 3/282 (1%) Query: 126 GTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVR 185 G PLR RVNPGARY AMEQFF +QVNLDAGP++GWAERVR Sbjct: 11 GCRPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVR 70 Query: 186 LAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEWARY 245 LAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P +WA+Y Sbjct: 71 LAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKY 130 Query: 246 ALRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPR 302 AL+APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPPVRPR Sbjct: 131 ALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPR 190 Query: 303 RWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHL 362 +WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL DR L Sbjct: 191 QWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRL 250 Query: 363 HTAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 + AA C+ +M L+ V + PADDFSD Sbjct: 251 YLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 292 >tr|D5Y9V3|D5Y9V3_MYCTU Tax_Id=520141 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis T85] Length = 282 Score = 336 bits (861), Expect = 4e-90 Identities = 166/263 (63%), Positives = 190/263 (72%), Gaps = 3/263 (1%) Query: 145 MEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTMIAITANSPML 204 MEQFF +QVNLDAGP++GWAERVRLAHALGPTMIAI ANSPML Sbjct: 1 MEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPML 60 Query: 205 GGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEWARYALRAPVMLVNSPDAVP--- 261 GG+F+GW STRQRVWGQ+DSARCGP+LG GD P +WA+YAL+APVM+V SPD Sbjct: 61 GGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRA 120 Query: 262 VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALWPAA 321 VT++VPF DW DGR +L GRR T ADL YHLTTLFPPVRPR+WLEIRYLDSVPD +WPA Sbjct: 121 VTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAV 180 Query: 322 VFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVXXXXXXXXXXX 381 VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL DR L+ AA C+ Sbjct: 181 VFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTEL 240 Query: 382 XXSMTLLMRSVQQRRSPADDFSD 404 +M L+ V + PADDFSD Sbjct: 241 IGAMQRLVDHVDRGVCPADDFSD 263 >tr|B1MFR8|B1MFR8_MYCA9 Tax_Id=561007 SubName: Full=Glutamate--cysteine ligase GshA;[Mycobacterium abscessus] Length = 416 Score = 332 bits (852), Expect = 5e-89 Identities = 184/386 (47%), Positives = 216/386 (55%), Gaps = 5/386 (1%) Query: 21 EQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLPGGSRIT 80 ++AA HI + D +G VGLE+E+H +L+ P RR +W+ L V VP LPG S IT Sbjct: 18 DEAAEHIARQAFADAQVGAVGLELESHTVELTAPHRRITWNRLREVGDSVPDLPGSSAIT 77 Query: 81 VEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVNPGA 140 EPGGAVELSGPP + + L LGTDPLR RVNPGA Sbjct: 78 FEPGGAVELSGPPCSDVWSAISSMRADHEILTAVYRGAGIALASLGTDPLRRPERVNPGA 137 Query: 141 RYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTMIAITAN 200 RY AME+ F +QVN+ +G W +R LA +GPTM A++A+ Sbjct: 138 RYVAMERHFGAAGYGETALQMMTCTASLQVNVQSGTPRQWRDRFVLAQRIGPTMAALSAS 197 Query: 201 SPMLGGQFTGWCSTRQRVWGQLDSARCGPV-LGVDGDDPASEWARYALRAPVMLVNSPD- 258 SPML G+ TG +TRQ +W LD RC PV +GVD P W YALRAPVMLV + D Sbjct: 198 SPMLTGRPTGRRNTRQWIWDNLDPRRCAPVEIGVD---PTESWVEYALRAPVMLVRNKDG 254 Query: 259 AVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALW 318 A V VPF W DG L GR PT DLDYHLTTLFPPVRPRRWLE+RYLD+ PD W Sbjct: 255 ADAVVTRVPFQSWVDGTMPLAGRAPTTEDLDYHLTTLFPPVRPRRWLELRYLDAAPDWWW 314 Query: 319 PAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVXXXXXXXX 378 PA FT LDDP A+ AAE PV AW AAR+GL D LH AA V Sbjct: 315 PALAFTAVAALDDPQVADIAAEIAEPVGNAWGVAARIGLEDPALHAAAHRLVSAACAVAP 374 Query: 379 XXXXXSMTLLMRSVQQRRSPADDFSD 404 M L+ V+Q R PADDF D Sbjct: 375 PELATDMEFLLERVEQGRCPADDFID 400 >tr|D5XNK6|D5XNK6_MYCTU Tax_Id=515617 SubName: Full=Glutamate-cysteine ligase gshA; Flags: Fragment;[Mycobacterium tuberculosis T92] Length = 259 Score = 280 bits (717), Expect = 2e-73 Identities = 139/243 (57%), Positives = 164/243 (67%) Query: 2 ALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWD 61 A ++ D+ VE T + AA +I L DGP+GRVGLE+EAHCFD ++P RRPSW+ Sbjct: 17 AAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWE 76 Query: 62 ELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 E++ V+ + PLPGGS ++VEPGGAVELSGPP DG A LG Sbjct: 77 EITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLG 136 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA 181 LV LG DPLR RVNPGARY AMEQFF +QVNLDAGP++GWA Sbjct: 137 LVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWA 196 Query: 182 ERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASE 241 ERVRLAHALGPTMIAI ANSPMLGG+F+GW STRQRVWGQ+DSARCGP+LG GD P + Sbjct: 197 ERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGID 256 Query: 242 WAR 244 WA+ Sbjct: 257 WAK 259 >tr|D3LZ15|D3LZ15_9ACTO Tax_Id=656024 SubName: Full=Glutamate/cysteine ligase family protein;[Frankia symbiont of Datisca glomerata] Length = 545 Score = 275 bits (703), Expect = 9e-72 Identities = 174/429 (40%), Positives = 206/429 (48%), Gaps = 32/429 (7%) Query: 6 RSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRR-PSWDELS 64 RSD G + S E + L D P G VG+E E D+++P R P L+ Sbjct: 49 RSDGGLRADDKIRSPEDVHRYAHLTCLTDQPAGNVGIETEWFVVDIASPARPVPPGRTLT 108 Query: 65 AVIADVPP---------------------LPGGSRITVEPGGAVELSGPPYDGPXXXXXX 103 A+ PP LPGG+R+T EPGG +ELS PP P Sbjct: 109 ALTGSPPPRPSRDGETSPQTSPEPVDELFLPGGTRLTFEPGGQLELSAPPLPLPDALART 168 Query: 104 XXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXX 163 A L L +GTDPLRP RR RY AM+Q+F Sbjct: 169 ATDLTAVRAM-LADAGLALAAMGTDPLRPPRRQLHAPRYVAMQQYFRRTDGGRAGEAMMC 227 Query: 164 XXXXVQVNLDAGPRDGWAERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLD 223 VQVNLDAG WA R LAHALGP ++A+ A SP+L G TGW STRQ +W +D Sbjct: 228 STASVQVNLDAGATARWARRFELAHALGPVLVAMFAASPVLAGTATGWRSTRQSLWADID 287 Query: 224 SARCGPVLGVDGDDPASEWARYALRAPVMLVNSPDA--VPVTNWVPFADWADGRAVLGGR 281 +R PV DPA+ WA Y L A VMLV PD + FADW G + R Sbjct: 288 PSRTSPVAAPHQPDPATAWADYLLAARVMLVRLPDGDFQLARDGSTFADWVAGAGPVA-R 346 Query: 282 RPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEA 341 PT ADL YH TT+FPPVRPR WLE+RYLD+ P WP AV T LLDDP AA++AA+A Sbjct: 347 PPTVADLRYHATTVFPPVRPRGWLELRYLDAAPAGNWPVAVAVTTALLDDPRAADTAADA 406 Query: 342 TRPVATAWDRAARMGLTDRHLHTAALTCVXXXXXXXXXXXXXSM------TLLMRSVQQR 395 PVA W AA +GL D LH AA C T L V+ Sbjct: 407 CEPVAGRWLTAAALGLRDDMLHRAARRCAGAARDALGHLGVDDALLAAVDTYLETYVEPG 466 Query: 396 RSPADDFSD 404 R PADD D Sbjct: 467 RCPADDLID 475 >tr|D1VG95|D1VG95_9ACTO Tax_Id=298654 SubName: Full=Glutamate/cysteine ligase family protein;[Frankia sp. EuI1c] Length = 442 Score = 260 bits (664), Expect = 3e-67 Identities = 157/346 (45%), Positives = 193/346 (55%), Gaps = 10/346 (2%) Query: 32 LQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADV-PPLPGGSRITVEPGGAVELS 90 L D +G+VG+E E D +P + + A +A P LPGGSRIT EPGG ELS Sbjct: 36 LADTAVGQVGIETEWFVVDRHSPDSPVAPERTRAALAGCGPDLPGGSRITFEPGGQFELS 95 Query: 91 GPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVNPGARYSAMEQFFX 150 GPP P A L L LG DPLR RR+ +RY+AME+FF Sbjct: 96 GPPLALPAALRAMSADLTAVRL-RLADDGLLLAGLGADPLRAPRRLLTHSRYAAMEEFFQ 154 Query: 151 XXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTMIAITANSPMLGGQFTG 210 +QVNL+AGPR GW +R RLAH LGP ++A+ A+SP+L G+ TG Sbjct: 155 TGGFPAGPLMMCSTAA-LQVNLEAGPRSGWEDRWRLAHTLGPVLVAMFASSPVLAGRPTG 213 Query: 211 WCSTRQRVWGQLDSARCGPVLGVDGD----DPASEWARYALRAPVMLVNSPDA--VPVTN 264 STRQ +W +D+ R PV PA+EWARY L A +MLV D +PV + Sbjct: 214 QVSTRQGIWSDIDATRTTPVADAGTQFTTGGPAAEWARYLLDARLMLVRDGDDRYLPVRD 273 Query: 265 WVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALWPAAVFT 324 FADW G + RRPT ADL YH +T+FPPVRPR WLE+RYLD+ ALWP AV Sbjct: 274 GSTFADWVAGAGPVP-RRPTVADLAYHASTVFPPVRPRGWLELRYLDAQSPALWPVAVTV 332 Query: 325 LTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCV 370 LLDDP AA++A +A VA W AA +GL L TAAL CV Sbjct: 333 AAALLDDPRAADTARDACAGVAGRWAEAAALGLAQPDLRTAALRCV 378 >tr|A8L8S2|A8L8S2_FRASN Tax_Id=298653 SubName: Full=Glutamate--cysteine ligase GCS2;[Frankia sp.] Length = 472 Score = 226 bits (577), Expect = 4e-57 Identities = 159/396 (40%), Positives = 187/396 (47%), Gaps = 67/396 (16%) Query: 39 RVGLEIEAHCFDLSNPTRRPSWDELSAVIADV---------------------------- 70 RVG+E E D++NP R DE +A + V Sbjct: 18 RVGIETEWFVVDVANPRRPVPADETAAALESVLAPGDQGRQPDRGRENRGRENGQARDGG 77 Query: 71 PP-------LPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLV 123 PP LPGGSR+T EPGG +ELSGPP D ARR LGLV Sbjct: 78 PPGTDSALRLPGGSRLTFEPGGQLELSGPPLD-LTAAVDAMRADLALVRGALARRRLGLV 136 Query: 124 LLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA-E 182 +G DPLR R +RY AMEQ F VQVNLD G A E Sbjct: 137 GMGVDPLRTPVRHTTASRYVAMEQHFLARDCDDGRTMMCSTAS-VQVNLDIGTDTAQAVE 195 Query: 183 RVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVL----------- 231 R RLAHAL P +IA+ A SP+ G+ W S RQ VW +D++R GPVL Sbjct: 196 RFRLAHALEPVLIAMFAASPLAHGRQISWQSGRQAVWAGIDASRTGPVLPDPAAPATAWL 255 Query: 232 -----GVDGDDPASE----------WARYALRAPVMLVNSPDA--VPVTNWVPFADWADG 274 G GD P + WARY A +M+V PD PV N F DW G Sbjct: 256 AQAGPGGRGDAPGAPPTGDAQLAWLWARYLHDADLMMVGEPDGRYQPVRNRTTFGDWMAG 315 Query: 275 RAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVA 334 + R PT DL +H TTLFPPVRPR WLE+RYLD+ P LWP AV LLD+P A Sbjct: 316 AGPVA-RPPTAQDLGWHATTLFPPVRPRGWLELRYLDAQPSDLWPVAVAVPAVLLDEPAA 374 Query: 335 AESAAEATRPVATAWDRAARMGLTDRHLHTAALTCV 370 A +A A PVA AA++GL D LH AA+ CV Sbjct: 375 ARAALAACLPVARQGRLAAQLGLRDPALHRAAVRCV 410 >tr|D3D6J4|D3D6J4_9ACTO Tax_Id=102897 SubName: Full=Glutamate/cysteine ligase family protein;[Frankia sp. EUN1f] Length = 572 Score = 225 bits (574), Expect = 8e-57 Identities = 170/469 (36%), Positives = 209/469 (44%), Gaps = 77/469 (16%) Query: 4 PARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDEL 63 PA S +G ++ E AA G + RVG+E+E D++ P+R DE Sbjct: 89 PAGSGAGAGAGAGASAGEGAAEAAGRADTR-----RVGIELEWLVVDVARPSRSVPPDET 143 Query: 64 SAVIAD----------------------------------------------VPPLPGGS 77 +A + + +P LPGGS Sbjct: 144 AAALVEALGTTGALRTTGALGTAGASVRSALPGPGPGPGPGAGPPAPPTSPSLPSLPGGS 203 Query: 78 RITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVN 137 R+T EPGG +ELSGPP AR LGL LG DPLRP RR Sbjct: 204 RLTFEPGGQLELSGPPLP-LADAVAAMRGDLTLVRGALARHGLGLAGLGVDPLRPPRRHT 262 Query: 138 PGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA-ERVRLAHALGPTMIA 196 +RY AME+ F VQVNLD+G ER RLAHAL P +IA Sbjct: 263 AASRYVAMEEHFRAVGGEAGLTMMCSTAS-VQVNLDSGADVAQTVERFRLAHALEPVLIA 321 Query: 197 ITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEW-------------A 243 + A SPM Q W S RQ VW ++D +R GPVL D P ++W A Sbjct: 322 MFAASPMPADQPIAWQSGRQEVWARIDPSRTGPVLP-DPTVPPTDWNPRGGTDHLAWLWA 380 Query: 244 RYALRAPVMLVNSPDAV--PVTNWVPFADW-ADGRAVLGGRRPTEADLDYHLTTLFPPVR 300 RY A +M++ D V + F DW A GRA RRPT DL +H TTLFPPVR Sbjct: 381 RYLRDAHLMMIAGDDGEYQAVGHRATFGDWLAGGRAAPSTRRPTRQDLGWHATTLFPPVR 440 Query: 301 PRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDR 360 PR WLE+RYLD+ P LWP V + L DDP+AA A A+ VA AAR+GL D Sbjct: 441 PRGWLELRYLDAQPSELWPVPVAVASVLFDDPLAAREALAASVAVAGRARLAARLGLRDP 500 Query: 361 HLHTAALTCVXXXXXXXXXXXXXSMTLLM------RSVQQRRSPADDFS 403 LH AA+ CV L R ++RRSPADD S Sbjct: 501 ALHRAAVRCVDLAVEALTRAGGDPELRLAVEAFADRYTRRRRSPADDLS 549 >tr|Q0RAS7|Q0RAS7_FRAAA Tax_Id=326424 (gshA)SubName: Full=Glutamate--cysteine ligase GSHA (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS); EC=6.3.2.2;[Frankia alni] Length = 523 Score = 221 bits (562), Expect = 2e-55 Identities = 147/367 (40%), Positives = 177/367 (48%), Gaps = 36/367 (9%) Query: 71 PPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPL 130 P LPGGSR+T EPGG +ELSGPP G A L +V +G DPL Sbjct: 138 PVLPGGSRLTFEPGGQLELSGPPA-GLAAAVQSTAADLHLVRAALAEDGLAIVGMGVDPL 196 Query: 131 RPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWA-ERVRLAHA 189 R R +RY+AME+ F VQVNLD G A ER RLAHA Sbjct: 197 RAGVRQTTASRYAAMEEHFRTGGGTSGEVMMRSTAS-VQVNLDLGTTPAQAAERFRLAHA 255 Query: 190 LGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVD------GD------- 236 +GP + A+ A SP L G+ TGW STRQ VW +D+ R G VL + GD Sbjct: 256 VGPVLTAMFAASPALAGRRTGWRSTRQAVWSGIDAGRTGSVLDLPAQPAAGGDAGPGAAA 315 Query: 237 ----DPASEWARYALRAPVMLVNSPDA----------VPVTNWVPFADWADGRAVLGGRR 282 D A WARY L A +M++ P V T F DW GR + R Sbjct: 316 ARSGDLADRWARYLLAAKLMMIGDPLGDVGPGEDRRFVAATGGHTFGDWVAGRGPVE-RA 374 Query: 283 PTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEAT 342 PT DL YH TTLFPPVRPR W E+RYLD+ P W AV T LLDDPVAA +AA+ Sbjct: 375 PTLDDLSYHATTLFPPVRPRGWWELRYLDAQPAEGWRVAVAVATALLDDPVAAAAAAQVC 434 Query: 343 RPVATAWDRAARMGLTDRHLHTAALTCVXXXXXXXXXXXXXSMT-----LLMRSVQQRRS 397 PVA W AA +G+ D L AA+ C+ + R Q+ R Sbjct: 435 APVARRWPAAAMLGMADEPLRLAAVRCLELAAAALRRAGCADLADAVELFSERYPQRGRC 494 Query: 398 PADDFSD 404 PAD+ S+ Sbjct: 495 PADELSE 501 >tr|Q2J4D5|Q2J4D5_FRASC Tax_Id=106370 SubName: Full=Glutamate--cysteine ligase, GCS2; Flags: Precursor;[Frankia sp.] Length = 502 Score = 216 bits (549), Expect = 6e-54 Identities = 167/450 (37%), Positives = 205/450 (45%), Gaps = 62/450 (13%) Query: 9 SGCAVPVEFTSAEQAAAH--------IGANSLQDG--------PIGRVGLEIE------- 45 +GC PV T E A + I N +D P G VG+E E Sbjct: 39 AGCVTPVHGTGDEAAYGNDRGNDRKGIRGNDRKDTRGNGGPTVPGGCVGIETEWLIVDTQ 98 Query: 46 -AHCF-----DLSNPTRRPSWDELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXX 99 HC L++ R P + P LPGGSRIT EPGG +ELSGPP + Sbjct: 99 AVHCLIPPARTLASLARIPG----TTPGPGGPVLPGGSRITFEPGGQLELSGPPAE-LTA 153 Query: 100 XXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXX 159 A L LV +G DPLR R +RY+AME+ F Sbjct: 154 AVRASSADLNLVRSALAVDGLALVGMGVDPLRVGMRQTTASRYAAMEEHFRTGGGASGTV 213 Query: 160 XXXXXXXXVQVNLDAG--PRDGWAERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQR 217 VQVNLD G P + A R +L HALGP + A+ A SP G+ TGW STRQ Sbjct: 214 MMYSTAS-VQVNLDLGGSPAEA-ARRFQLVHALGPVLTALFAASPAYAGRRTGWRSTRQA 271 Query: 218 VWGQLDSARCGPVLGV-----DGD---DPASEWARYALRAPVMLVNSPDA---------- 259 VW +D++R PV GD D WARY L A +M+V +P Sbjct: 272 VWDGIDASRTRPVAAALTAPGSGDTEPDLVDLWARYLLDAKLMMVENPARAGNPEDDHHF 331 Query: 260 VPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALWP 319 VPV + F DW GR + R PT DL YH TT+FPPVRPR W E+RYLD+ P W Sbjct: 332 VPVRDDSTFGDWLAGRGPVT-RPPTREDLSYHATTVFPPVRPRGWWELRYLDAQPGDGWQ 390 Query: 320 AAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVXXXXXXXXX 379 AAV T LLDDPVAA+ A EA VA W AA +G+ D L AA+ CV Sbjct: 391 AAVAMPTVLLDDPVAADGAFEACLAVAHRWPAAAMLGMADEPLRRAAVRCVDLAVSALRR 450 Query: 380 XXXXSMTLLMRSVQQR-----RSPADDFSD 404 + + S R R PAD+ ++ Sbjct: 451 GGATDLAETVESFAGRYLDRGRCPADELTE 480 >tr|D1ACB6|D1ACB6_THECD Tax_Id=471852 SubName: Full=Glutamate/cysteine ligase family protein;[Thermomonospora curvata] Length = 399 Score = 214 bits (545), Expect = 2e-53 Identities = 150/393 (38%), Positives = 177/393 (45%), Gaps = 22/393 (5%) Query: 26 HIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLPGGSRITVEPGG 85 H + GP G+VG E E D ++P + + A PLPG S IT EPGG Sbjct: 12 HTRGVCFKTGPPGKVGAETEWLVIDPADPAAHVPLERVRAAAEAGGPLPGRSVITYEPGG 71 Query: 86 AVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVNPGARYSAM 145 +ELS DG A L LV G DPLR R RY M Sbjct: 72 QLELSSRVCDGLADLHEALSQDLASVRARLAADGLDLVGRGVDPLRRPRLQAAHPRYRCM 131 Query: 146 EQFFXXXXXXXXXXXXXXXXXXVQVNLDAG--PRDGWAERVRLAHALGPTMIAITANSPM 203 +F VQV LD G P D R RLAHALGP ++A ANSP+ Sbjct: 132 YDYFAGGGYRETGATMMCSTASVQVCLDIGADPADA-LRRWRLAHALGPVLVAAFANSPL 190 Query: 204 LGGQFTGWCSTRQRVWGQLDSARCGPVL--GVDGDDPASEWARYALRAPVMLVNSPDAVP 261 G+ TG STRQ +W LD R PVL G DP W RYA+ APVML P Sbjct: 191 RAGRRTGLRSTRQAIWAALDPCRTRPVLEAGTGPADPCRAWTRYAIDAPVMLTR-PRPGT 249 Query: 262 VTNW-----VPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDA 316 W + F +W D P D YHL+TLFPPVRPR WLE+R +D++P Sbjct: 250 SDGWTGAPGMTFGEWMDKG------EPCLDDFAYHLSTLFPPVRPRGWLELRMIDALPLR 303 Query: 317 LWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLHTAALTCVXXXXXX 376 WP V T LLDDP A A +A RPVA W AAR LTD L AA C Sbjct: 304 YWPVPVAVATALLDDPQAGRIAEDAARPVAGRWGAAARHALTDPALALAARRCFAAALQA 363 Query: 377 XXXXXXXSMTLLM-----RSVQQRRSPADDFSD 404 + L+ R V++ R PADD +D Sbjct: 364 LPRLGAAELVPLVADYARRYVERGRCPADDPAD 396 >tr|C1YNM4|C1YNM4_NOCDA Tax_Id=446468 SubName: Full=Glutamate--cysteine ligase family protein;[Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] Length = 428 Score = 212 bits (540), Expect = 7e-53 Identities = 139/369 (37%), Positives = 176/369 (47%), Gaps = 30/369 (8%) Query: 19 SAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLPGGSR 78 + E +I + GP G+VG E E D ++PT D L+A++ P P GS Sbjct: 6 TTEDVHEYINGVCFKTGPPGKVGAETEWLVADSADPTAPVPVDRLAALVESCGPPPSGSG 65 Query: 79 ITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLGTDPLRPTRRVNP 138 +T EPGG +ELS P GP A L LV DP RP RR Sbjct: 66 VTFEPGGQLELSSPALPGPARAHAALSADLDHVGKALAEAGLHLVETALDPARPPRRQLR 125 Query: 139 GARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGP-----RDGWAERVRLAHALGPT 193 ARY+AME+FF +QV LD G RD W L H LGP Sbjct: 126 EARYTAMERFFAHHRQPSGYTMMCSTAS-LQVCLDTGEDAADVRDRW----ELVHRLGPV 180 Query: 194 MIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGD-DPASEWARYALRAPVM 252 ++A ANS + G+ TGW STR +W D+ R PVL DPA+ WA YAL A VM Sbjct: 181 LVAAFANSAVWRGRPTGWKSTRWAIWAATDATRTRPVLDAGSPADPATAWAEYALAARVM 240 Query: 253 LVNSPDAVPVTNWVP-----FADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEI 307 V + W P F+ W DG+ G R T ADL++HL+TLFPPVRPR W E+ Sbjct: 241 AVPGGEGP----WTPDPGVTFSQWLDGQ---GPRPATRADLEFHLSTLFPPVRPRGWWEL 293 Query: 308 RYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATR-------PVATAWDRAARMGLTDR 360 R +D++P WP V L+DDP A +A EAT P W R+AR+G+ D Sbjct: 294 RMIDALPVRWWPVPVALAAALVDDPRARAAAEEATEELCGGRSPDRHLWLRSARLGMADP 353 Query: 361 HLHTAALTC 369 + A C Sbjct: 354 DVARCARAC 362 >tr|C8XBM8|C8XBM8_NAKMY Tax_Id=479431 SubName: Full=Glutamate/cysteine ligase family protein;[Nakamurella multipartita] Length = 445 Score = 210 bits (535), Expect = 3e-52 Identities = 157/414 (37%), Positives = 200/414 (48%), Gaps = 31/414 (7%) Query: 13 VPVEFTSAEQAA-AHIGANSLQDGPIGRVGLEIE---AHCFDLSNPTRRP--SWDELSAV 66 +PVE T +E AA A I ++GP RVGLE+E A D + T P + L Sbjct: 16 LPVEPTLSEAAAEAWIPRTFFKNGPPHRVGLELEFLVAGTGDDALATHYPHEQYPHLIDR 75 Query: 67 IADVPP--LPGGS---RITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLG 121 + D PP PGG R+TVEPGG VELS P D R Sbjct: 76 LIDGPPDSPPGGGLDGRVTVEPGGQVELSSRPGDSLAATVDTVHHDLARLRRRARGRGAR 135 Query: 122 LVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAG-PRDGW 180 LV LG DP+RP RR+ RY AME++F VQVN++A P Sbjct: 136 LVGLGVDPIRPPRRITDQPRYRAMERYFRPWGATGPAMMCSTAS--VQVNVEAATPAVDL 193 Query: 181 AERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPAS 240 R L HA+GPT++A ANSP G+ TG+ STRQ +W +LD AR G G+DPA+ Sbjct: 194 HRRWELLHAIGPTLVAAFANSPRRLGRATGFQSTRQAIWQELDPARTGAPPRAPGEDPAT 253 Query: 241 EWARYALRAPVMLV-------NSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLT 293 + R++L APVML+ ++P + + +W+ RAV PT DL YHL+ Sbjct: 254 AFTRWSLDAPVMLIRREHDDWSAPPELSMRSWIRHGR----RAVPDRPAPTVDDLAYHLS 309 Query: 294 TLFPPVRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAA 353 TLFPPVRPR LEIRYLD++P W + LLDDP AA+ A PV W AA Sbjct: 310 TLFPPVRPRGHLEIRYLDALPGCWWIVPAAVIAALLDDPAAADQARATCEPVQEHWRTAA 369 Query: 354 RMGLTDRHLHTAALTCVXXXXXXXXXXXXXSM------TLLMRSVQQRRSPADD 401 R G+ D L AA + + L R + RSPADD Sbjct: 370 RSGVRDPALGRAATALLTTAAQALRRDPTAARFADPVEGYLQRWTLRGRSPADD 423 >tr|D2B0V7|D2B0V7_STRRD Tax_Id=479432 SubName: Full=Glutamate/cysteine ligase;[Streptosporangium roseum] Length = 408 Score = 210 bits (534), Expect = 3e-52 Identities = 145/335 (43%), Positives = 169/335 (50%), Gaps = 22/335 (6%) Query: 39 RVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPX 98 +VG+E+E FD ++P L+ V +PPLPGGSR+T EPGG +ELSGP GP Sbjct: 32 QVGVELEFLVFDRTSPDCHVP---LARVAGALPPLPGGSRVTFEPGGQLELSGPA--GPL 86 Query: 99 XXXXXXXXXXXXXXXEFARRNLGLVL--LGTDPLRPTRRVNPGARYSAMEQFFXXXXXXX 156 A R GLVL +G DP+RP RR RY AM +F Sbjct: 87 PEAIARLAADVDAARA-ALREAGLVLAGVGLDPIRPARRQLRLPRYEAMAEFLGTPYGSL 145 Query: 157 XXXXXXXXXXXVQVNLDAGPRDGWAERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQ 216 +QVNLD G R A R AH LGP + A ANSP+ GG+ GW S RQ Sbjct: 146 MMCSTAS----IQVNLDLGDRP--AVRWERAHLLGPVLTAAFANSPLSGGRPCGWMSGRQ 199 Query: 217 RVWGQLDSARCGPVLGVDGDDPASEWARYALRAPVMLV--NSPDAVPVTNWVPFADWADG 274 VW LD R PV DPA+ WA Y L A +MLV N V + F DW Sbjct: 200 AVWENLDRTRTAPVPATG--DPAAAWAEYLLDARLMLVRENGDRCRTVRDGSTFRDWLAA 257 Query: 275 RAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVA 334 A R T ADL YH TT+FPPVRPR WLEIRYLD+ A WP V L+ D A Sbjct: 258 PA----RPLTLADLAYHATTIFPPVRPRGWLEIRYLDAQRPADWPVCVAVTHALVMDDRA 313 Query: 335 AESAAEATRPVATAWDRAARMGLTDRHLHTAALTC 369 AE+A A P A W AAR GL + L AA TC Sbjct: 314 AETAIAAAEPYAGMWPGAARHGLAEPRLRKAAETC 348 >tr|C6WGZ9|C6WGZ9_ACTMD Tax_Id=446462 SubName: Full=Glutamate--cysteine ligase GCS2;[Actinosynnema mirum] Length = 408 Score = 203 bits (516), Expect = 4e-50 Identities = 141/373 (37%), Positives = 169/373 (45%), Gaps = 27/373 (7%) Query: 14 PVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAVIADVPP- 72 P F +A A++ + + GP +G+EIE L +P+ SA + D P Sbjct: 15 PASFRDRAEAEAYVASVCFKHGPPRLIGVEIEWTVHHLGDPSLPVDAALFSAALGDHAPP 74 Query: 73 ----------LPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGL 122 LP G+ +TVEPGG VE+S PP D L Sbjct: 75 TLVPDSPQRTLPSGTPLTVEPGGQVEISTPPRDSLTELLKTVASDVDHLAGLLEPAGFTL 134 Query: 123 VLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRDGWAE 182 G DP RP RR+ RY AM+ F +QV LDAG A Sbjct: 135 GDRGADPFRPPRRLLDVPRYRAMQHAFDALGPDGLTMMCSTAG--LQVCLDAGEGPDVAT 192 Query: 183 RVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARCGPVLGVDGDDPASEW 242 R AHALGP ++A+ ANSP +GG+ W S R R D RC P G DDPAS W Sbjct: 193 RWAAAHALGPALMALFANSPGVGGRRPDWASARMRTLYGTDPVRCRP--GAVCDDPASAW 250 Query: 243 ARYALRAPVMLVNSPDAVPVTNWVP-----FADWADGRAVLGGRRPTEADLDYHLTTLFP 297 AR L APV++V P +W+P FADW DG RRPT DLDYHLT FP Sbjct: 251 ARRVLDAPVIVVRRPGP----DWIPPHRLTFADWVDGAL---DRRPTTEDLDYHLTLQFP 303 Query: 298 PVRPRRWLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGL 357 PVRPR +LEIRYLD+ W V L L P +S EAT P W AAR GL Sbjct: 304 PVRPRGYLEIRYLDTPGPGGWIPPVVLLAALFSHPSVVDSVLEATGPSVRRWLTAARHGL 363 Query: 358 TDRHLHTAALTCV 370 D L A V Sbjct: 364 DDPVLARVAAQVV 376 >tr|B5I149|B5I149_9ACTO Tax_Id=463191 SubName: Full=Putative uncharacterized protein;[Streptomyces sviceus ATCC 29083] Length = 434 Score = 192 bits (489), Expect = 6e-47 Identities = 145/423 (34%), Positives = 189/423 (44%), Gaps = 34/423 (8%) Query: 7 SDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSWDELSAV 66 + + C P + A + + GP R+G+E+E +L NP + ++L+A Sbjct: 9 TSADCTKPRTSLPEAELEALVRGICFKTGPPRRIGVEVEWLVHELRNPRLPVTSEQLAAA 68 Query: 67 IADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNLGLVLLG 126 A + +P S +TVEPGG +ELS P D A LGLV LG Sbjct: 69 YAALRAVPLKSALTVEPGGQLELSSQPADSLMECIGTVSADLAAVRAALAEHGLGLVGLG 128 Query: 127 TDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRD----GWAE 182 DP P RR RY AME VQV +DAG + G Sbjct: 129 HDPWHPPRRYLREPRYDAMEACLDRTGPAGRAMMCTSAS--VQVCVDAGHEEPGPLGLGR 186 Query: 183 RVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSARC-GPVLGVDGDDPASE 241 R LAH LGP ++A ANSP+ G + TGW STRQ W ++ R GP L DP S Sbjct: 187 RWSLAHQLGPVLVAAFANSPLAGSEPTGWLSTRQLRWTEIGKGRAGGPSLDT---DPRSA 243 Query: 242 WARYALRAPVMLVNSPDAVP--VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPV 299 W R+ L APVM + D+ P + + F +WA R PT DLDYH++TLFPPV Sbjct: 244 WTRHVLDAPVMCIRR-DSGPWDIPEGLSFREWARSGV---PRPPTREDLDYHVSTLFPPV 299 Query: 300 RPRRWLEIRYLDSVP-DALWPAAVFTLTTLLDDPVAAESAAEATRPVA-----------T 347 RPR LE+R +D+ P + W + L DDP AAE+A +P+A Sbjct: 300 RPRGHLELRMIDAQPGEDGWIVPLAVTAALFDDPQAAETAYRVVKPLAERTLSMPAPHNP 359 Query: 348 AWDRAARMGLTDRHLHTAALTCVXXXXXXXXXXXXXSM------TLLMRSVQQRRSPADD 401 W AAR GL D L AA+ C + L R V + R PADD Sbjct: 360 LWIDAARHGLADPELCEAAIACFAAALEALPRLGATTEVTDAVGAYLHRYVIRGRCPADD 419 Query: 402 FSD 404 D Sbjct: 420 LLD 422 >tr|D5XNK5|D5XNK5_MYCTU Tax_Id=515617 SubName: Full=Glutamate-cysteine ligase gshA;[Mycobacterium tuberculosis T92] Length = 180 Score = 192 bits (487), Expect = 1e-46 Identities = 97/161 (60%), Positives = 113/161 (70%), Gaps = 3/161 (1%) Query: 247 LRAPVMLVNSPDAVP---VTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRR 303 ++APVM+V SPD VT++VPF DW DGR +L GRR T ADL YHLTTLFPPVRPR+ Sbjct: 1 MKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQ 60 Query: 304 WLEIRYLDSVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATAWDRAARMGLTDRHLH 363 WLEIRYLDSVPD +WPA VFTL TLLDDPVAA+ A +A PVATAWD AAR+GL DR L+ Sbjct: 61 WLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLY 120 Query: 364 TAALTCVXXXXXXXXXXXXXSMTLLMRSVQQRRSPADDFSD 404 AA C+ +M L+ V + PADDFSD Sbjct: 121 LAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSD 161 >tr|D1XI92|D1XI92_9ACTO Tax_Id=647653 SubName: Full=Glutamate/cysteine ligase family protein;[Streptomyces sp. ACTE] Length = 433 Score = 189 bits (479), Expect = 8e-46 Identities = 151/432 (34%), Positives = 183/432 (42%), Gaps = 39/432 (9%) Query: 1 MALPARSDSGCAVPVEFTSAEQAAAHIGANSLQDGPIGRVGLEIEAHCFDLSNPTRRPSW 60 M L G AV E ++A + + GP VG+E+E D P S Sbjct: 1 MPLDTPGAHGPAVEAEPLDEDEAQDRLRGICFKTGPPRTVGVELEWLIHDRERPEAAVSH 60 Query: 61 DELSAVIADVPPLPGGSRITVEPGGAVELSGPPYDGPXXXXXXXXXXXXXXXXEFARRNL 120 + L+A V P S +T EPGG +ELS P AR L Sbjct: 61 ERLTAAADAVRATPLDSALTFEPGGQLELSSRPAGSLTACVDAVSADMAAVRTVLARSGL 120 Query: 121 GLVLLGTDPLRPTRRVNPGARYSAMEQFFXXXXXXXXXXXXXXXXXXVQVNLDAGPRD-- 178 V LG DP +P RR+ RY+AME VQV +DAG + Sbjct: 121 EPVGLGVDPWQPPRRLLKEPRYAAMEAALDRSGDSGRAMMCTSAS--VQVCVDAGEEEPG 178 Query: 179 --GWAERVRLAHALGPTMIAITANSPMLGGQFTGWCSTRQRVWGQLDSAR--CGPVLGVD 234 G+ R +L H LG ++A ANSP G TGW STRQ +W LD AR PV Sbjct: 179 PLGFGRRWQLGHLLGAVLVAAFANSPFRQGVRTGWRSTRQALWADLDPARSLAPPV---- 234 Query: 235 GDDPASEWARYALRAPVMLVNSPDAVP--VTNWVPFADWADGRAVLGGRRP-TEADLDYH 291 P +WA Y L PVM + S D P V + F DW G GG RP ADLDYH Sbjct: 235 RRSPRDDWAGYVLDTPVMCIRSDDGTPWAVPEGLTFRDWIRG----GGPRPAVRADLDYH 290 Query: 292 LTTLFPPVRPRRWLEIRYLD--SVPDALWPAAVFTLTTLLDDPVAAESAAEATRPVATA- 348 +TTLFPPVRPR LE+R +D S PD W + T L DDP AAE+ +P+A Sbjct: 291 VTTLFPPVRPRGHLELRMIDAQSGPDG-WLVPLAVTTALFDDPEAAETVYRTVKPLAETA 349 Query: 349 ----------WDRAARMGLTDRHLHTAALTCVXXXXXXXXXXXXXS------MTLLMRSV 392 W AAR GL D L AA C R V Sbjct: 350 GPSPAPRNPLWTTAARDGLADPELAAAAKVCFAAASRALPGLGASGRVQDAVAAFTDRYV 409 Query: 393 QQRRSPADDFSD 404 + R PADD +D Sbjct: 410 VRGRCPADDLTD 421 Database: Amellifera_nr Posted date: Jul 23, 2010 5:10 AM Number of letters in database: 4,236,830,644 Number of sequences in database: 12,507,864 Lambda K H 0.319 0.135 0.428 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 12507864 Number of Hits to DB: 3,267,756,695 Number of extensions: 132412583 Number of successful extensions: 269235 Number of sequences better than 10.0: 420 Number of HSP's gapped: 269717 Number of HSP's successfully gapped: 420 Length of query: 423 Length of database: 4,236,830,644 Length adjustment: 141 Effective length of query: 282 Effective length of database: 2,473,221,820 Effective search space: 697448553240 Effective search space used: 697448553240 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 82 (36.2 bits)