BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MMAR_0844 (558 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,275,203 sequences; 3,846,993,858 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|B2HRJ3|B2HRJ3_MYCMM Tax_Id=216594 (hemD)SubName: Full=Uroporp... 964 0.0 tr|A0PW30|A0PW30_MYCUA Tax_Id=362242 (hemD)SubName: Full=Uroporp... 959 0.0 tr|Q73SR9|Q73SR9_MYCPA Tax_Id=1770 (cysG)SubName: Full=CysG;[Myc... 896 0.0 tr|A0QLH9|A0QLH9_MYCA1 Tax_Id=243243 (hemD)SubName: Full=Uroporp... 867 0.0 tr|C6DT97|C6DT97_MYCTK Tax_Id=478434 SubName: Full=Uroporphyrin-... 863 0.0 tr|Q7D9R0|Q7D9R0_MYCTU Tax_Id=1773 SubName: Full=Uroporphyrin-II... 863 0.0 tr|A2VFJ6|A2VFJ6_MYCTU Tax_Id=348776 SubName: Full=Uroporphyrin-... 863 0.0 tr|Q7TTP7|Q7TTP7_MYCBO Tax_Id=1765 (hemD)SubName: Full=PROBABLE ... 863 0.0 tr|Q6MX34|Q6MX34_MYCTU Tax_Id=1773 (hemD)SubName: Full=PROBABLE ... 863 0.0 tr|C1AKJ1|C1AKJ1_MYCBT Tax_Id=561275 (hemD)SubName: Full=Putativ... 863 0.0 tr|A5TZP1|A5TZP1_MYCTA Tax_Id=419947 (hemD)SubName: Full=Uroporp... 863 0.0 tr|A1KFY7|A1KFY7_MYCBP Tax_Id=410289 (hemD)SubName: Full=Probabl... 863 0.0 tr|A5WJM6|A5WJM6_MYCTF Tax_Id=336982 SubName: Full=Uroporphyrin-... 863 0.0 tr|A4KEJ7|A4KEJ7_MYCTU Tax_Id=395095 SubName: Full=Uroporphyrin-... 863 0.0 tr|Q9CB60|Q9CB60_MYCLE Tax_Id=1769 (hemD)SubName: Full=Possible ... 861 0.0 tr|B8ZT69|B8ZT69_MYCLB Tax_Id=561304 (hemD)SubName: Full=Possibl... 861 0.0 tr|A0QR19|A0QR19_MYCS2 Tax_Id=246196 (hemD)SubName: Full=Uroporp... 811 0.0 tr|A4T339|A4T339_MYCGI Tax_Id=350054 SubName: Full=Uroporphyrino... 806 0.0 tr|A1T3D4|A1T3D4_MYCVP Tax_Id=350058 SubName: Full=Uroporphyrino... 796 0.0 tr|Q1BE85|Q1BE85_MYCSS Tax_Id=164756 SubName: Full=Uroporphyrino... 792 0.0 tr|A1UAP9|A1UAP9_MYCSK Tax_Id=189918 SubName: Full=Uroporphyrino... 792 0.0 tr|A3PUA5|A3PUA5_MYCSJ Tax_Id=164757 SubName: Full=Uroporphyrino... 791 0.0 tr|B1MHI4|B1MHI4_MYCA9 Tax_Id=561007 SubName: Full=Possible Urop... 761 0.0 tr|Q49819|Q49819_MYCLE Tax_Id=1769 SubName: Full=CysG;[Mycobacte... 722 0.0 tr|Q5YP71|Q5YP71_NOCFA Tax_Id=37329 (hemDX)SubName: Full=Putativ... 693 0.0 tr|D0L4A2|D0L4A2_GORB4 Tax_Id=526226 SubName: Full=Uroporphyrin-... 687 0.0 tr|C0ZUV6|C0ZUV6_RHOE4 Tax_Id=234621 (cysGA/hemD)SubName: Full=U... 682 0.0 tr|C3JK03|C3JK03_RHOER Tax_Id=596309 (hemD)SubName: Full=Uroporp... 682 0.0 tr|Q0SF28|Q0SF28_RHOSR Tax_Id=101510 SubName: Full=Probable urop... 681 0.0 tr|C1AZ42|C1AZ42_RHOOB Tax_Id=632772 (cysGA/hemD)SubName: Full=P... 680 0.0 tr|C2AL33|C2AL33_TSUPA Tax_Id=521096 SubName: Full=Uroporphyrino... 680 0.0 tr|C6WNG1|C6WNG1_ACTMD Tax_Id=446462 SubName: Full=Uroporphyrin-... 629 e-178 tr|A4FPY2|A4FPY2_SACEN Tax_Id=405948 (hemD)SubName: Full=Uroporp... 614 e-174 tr|C7MT08|C7MT08_SACVD Tax_Id=471857 SubName: Full=Uroporphyrino... 606 e-171 tr|C8XAG5|C8XAG5_NAKMY Tax_Id=479431 SubName: Full=Uroporphyrin-... 572 e-161 tr|C0U8E1|C0U8E1_9ACTO Tax_Id=526225 SubName: Full=Uroporphyrino... 531 e-149 tr|C4RC05|C4RC05_9ACTO Tax_Id=219305 SubName: Full=Uroporphyrino... 503 e-140 tr|Q8FSE4|Q8FSE4_COREF Tax_Id=152794 SubName: Full=Putative urop... 500 e-139 tr|C8NSF6|C8NSF6_COREF Tax_Id=196164 (hemD)SubName: Full=Uroporp... 500 e-139 tr|C4LLC0|C4LLC0_CORK4 Tax_Id=645127 SubName: Full=Uroporphyrin-... 500 e-139 tr|A8LZJ1|A8LZJ1_SALAI Tax_Id=391037 SubName: Full=Uroporphyrino... 495 e-138 tr|A4X1U3|A4X1U3_SALTO Tax_Id=369723 SubName: Full=Uroporphyrino... 495 e-138 tr|C2GGC0|C2GGC0_9CORY Tax_Id=548478 SubName: Full=Uroporphyrin-... 494 e-137 tr|C0VR96|C0VR96_9CORY Tax_Id=548477 SubName: Full=Uroporphyrin-... 494 e-137 tr|C8RUU7|C8RUU7_CORJE Tax_Id=525262 (hemD)SubName: Full=Uroporp... 494 e-137 tr|Q8NT81|Q8NT81_CORGL Tax_Id=1718 SubName: Full=Uroporphyrinoge... 493 e-137 tr|Q6M7T9|Q6M7T9_CORGL Tax_Id=1718 (hemD)SubName: Full=UROPORPHY... 493 e-137 tr|A4QB70|A4QB70_CORGB Tax_Id=340322 SubName: Full=Putative unch... 491 e-137 tr|Q8GMZ0|Q8GMZ0_CORGL Tax_Id=1718 (hemD)SubName: Full=Uroporpho... 491 e-137 tr|Q4JSX6|Q4JSX6_CORJK Tax_Id=306537 (hemD)SubName: Full=Uroporp... 488 e-136 >tr|B2HRJ3|B2HRJ3_MYCMM Tax_Id=216594 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase HemD;[Mycobacterium marinum] Length = 558 Score = 964 bits (2491), Expect = 0.0 Identities = 496/558 (88%), Positives = 496/558 (88%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 MMTRGRKPRPGRITYVGSGPGDPG FTDPDVPESVLALIGNDLPP Sbjct: 1 MMTRGRKPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPP 60 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG GGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS Sbjct: 61 VSGPAPATAVADNADAATGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD Sbjct: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 Query: 181 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET Sbjct: 181 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 Query: 241 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA 300 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA Sbjct: 241 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA 300 Query: 301 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 360 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK Sbjct: 301 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 360 Query: 361 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP 420 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP Sbjct: 361 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP 420 Query: 421 VNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFT 480 VNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTGGFDAVCFT Sbjct: 421 VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFT 480 Query: 481 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXX 540 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD Sbjct: 481 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAA 540 Query: 541 XXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 541 RLRAEGALPPPRKKSRRR 558 >tr|A0PW30|A0PW30_MYCUA Tax_Id=362242 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase HemD;[Mycobacterium ulcerans] Length = 557 Score = 959 bits (2480), Expect = 0.0 Identities = 494/557 (88%), Positives = 494/557 (88%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRITYVGSGPGDPG FTDPDVPESVLALIGNDLPPV Sbjct: 1 MTRGRKPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG Sbjct: 61 SGPAPATAVADNADAATGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 120 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV Sbjct: 121 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 180 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT Sbjct: 181 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 240 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG Sbjct: 241 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 300 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 EMSERLTSYGALPVEVPTIAV PPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF Sbjct: 301 EMSERLTSYGALPVEVPTIAVAPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 360 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV Sbjct: 361 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 420 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 NRVLLPRADIATETLAEGLRERGWEIEDV EMIKTGGFDAVCFTS Sbjct: 421 NRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFTS 480 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD Sbjct: 481 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAAR 540 Query: 542 XXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 541 LRAEGALPPPRKKSRRR 557 >tr|Q73SR9|Q73SR9_MYCPA Tax_Id=1770 (cysG)SubName: Full=CysG;[Mycobacterium paratuberculosis] Length = 552 Score = 896 bits (2316), Expect = 0.0 Identities = 458/558 (82%), Positives = 474/558 (84%), Gaps = 6/558 (1%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 M TRGRKP PGRITYVGSGPGDPG FTDPDVPE VLALIG DLPP Sbjct: 1 MTTRGRKPTPGRITYVGSGPGDPGLLTARAATVLANAALVFTDPDVPEPVLALIGKDLPP 60 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG G + E QA PAV+S GPDIRPALGDP EVAKTLTAEAR+ Sbjct: 61 VSGPAPAEPASN------GEGSGSEQGQAQPAVISGGPDIRPALGDPAEVAKTLTAEART 114 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 G DVVRLVAGDP++VDAVI EVNAI RSHL IEI+PGLA T+AVPTYAGLPLGS+HT+AD Sbjct: 115 GVDVVRLVAGDPLTVDAVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMAD 174 Query: 181 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 VRGDVDWEALAAAPGPLILQATASHLADAARTL+EHELA+ TPCVVTAHGTTCQQRS+ET Sbjct: 175 VRGDVDWEALAAAPGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIET 234 Query: 241 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA 300 TLQGLTD A+LGGTDPAGPLTGPLVVTIGKTVS R KLNWWESRALYGWTVLVPRTKDQA Sbjct: 235 TLQGLTDSAVLGGTDPAGPLTGPLVVTIGKTVSARTKLNWWESRALYGWTVLVPRTKDQA 294 Query: 301 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 360 GEMSERLTSYGALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK Sbjct: 295 GEMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 354 Query: 361 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP 420 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLD+FPPYDS+FDP Sbjct: 355 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSVFDP 414 Query: 421 VNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFT 480 VNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTGGFDAVCFT Sbjct: 415 VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFT 474 Query: 481 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXX 540 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD Sbjct: 475 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAA 534 Query: 541 XXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 535 RLRAEGALPPPRKKSRRR 552 >tr|A0QLH9|A0QLH9_MYCA1 Tax_Id=243243 (hemD)SubName: Full=Uroporphyrinogen-III synthase; EC=4.2.1.75;[Mycobacterium avium] Length = 537 Score = 867 bits (2240), Expect = 0.0 Identities = 445/543 (81%), Positives = 461/543 (84%), Gaps = 6/543 (1%) Query: 16 VGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXXXXXXXX 75 +GSGPGDPG FTDPDVPE VLALIG DLPPVSG Sbjct: 1 MGSGPGDPGLLTARAAAVLANAALVFTDPDVPEPVLALIGKDLPPVSGPAPAEPAPN--- 57 Query: 76 XXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVAGDPMSV 135 G A E QA PAV+S GPDIRPALGDP EVAKTLTAEAR+G DVVRLVAGDP++V Sbjct: 58 ---GEGAGSEQGQAQPAVISGGPDIRPALGDPAEVAKTLTAEARTGVDVVRLVAGDPLTV 114 Query: 136 DAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGDVDWEALAAAPG 195 DAVI EVNAI RSHL IEI+PGLA T+AVPTYAGLPLGS+HT+ADVRGDVDWEALAAAPG Sbjct: 115 DAVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRGDVDWEALAAAPG 174 Query: 196 PLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDPAILGGTD 255 PLILQATASHLADAARTL+EHELA+ TPCVVTAHGTTCQQRS+ETTLQGLTD A+LGGTD Sbjct: 175 PLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIETTLQGLTDSAVLGGTD 234 Query: 256 PAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPV 315 PAGPLTGPLVVTIGKTVS RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALP+ Sbjct: 235 PAGPLTGPLVVTIGKTVSARAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPI 294 Query: 316 EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVK 375 EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVK Sbjct: 295 EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVK 354 Query: 376 IACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPVNRVLLPRADIATET 435 IACVGESTADRVRAFGISPELVPAGEQSSLGLLD+FP YDS+FDPVNRVLLPRADIATET Sbjct: 355 IACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPLYDSVFDPVNRVLLPRADIATET 414 Query: 436 LAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRNLVGIAGKP 495 LAEGLRERGWEIEDV EMIKTGGFDAVCFTSSSTVRNLVGIAGKP Sbjct: 415 LAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVRNLVGIAGKP 474 Query: 496 HARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXXXPPPRKKS 555 HARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD PPPRKKS Sbjct: 475 HARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAEGALPPPRKKS 534 Query: 556 RRR 558 RRR Sbjct: 535 RRR 537 >tr|C6DT97|C6DT97_MYCTK Tax_Id=478434 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis] Length = 568 Score = 863 bits (2230), Expect = 0.0 Identities = 442/567 (77%), Positives = 475/567 (83%), Gaps = 10/567 (1%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 +MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPP Sbjct: 3 IMTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPP 62 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARS Sbjct: 63 VSGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARS 121 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 G DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVAD Sbjct: 122 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 181 Query: 181 VRGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRS 237 VR D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRS Sbjct: 182 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 241 Query: 238 VETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTV 291 VETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTV Sbjct: 242 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 301 Query: 292 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 351 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 302 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 361 Query: 352 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEF 411 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+F Sbjct: 362 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 421 Query: 412 PPYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKT 471 PPYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKT Sbjct: 422 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 481 Query: 472 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPL 531 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPL Sbjct: 482 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 541 Query: 532 VDXXXXXXXXXXXXXXXPPPRKKSRRR 558 VD PPPRKKSRRR Sbjct: 542 VDALAEHAARLRAEGALPPPRKKSRRR 568 >tr|Q7D9R0|Q7D9R0_MYCTU Tax_Id=1773 SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107;[Mycobacterium tuberculosis] Length = 568 Score = 863 bits (2230), Expect = 0.0 Identities = 442/567 (77%), Positives = 475/567 (83%), Gaps = 10/567 (1%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 +MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPP Sbjct: 3 IMTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPP 62 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARS Sbjct: 63 VSGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARS 121 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 G DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVAD Sbjct: 122 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 181 Query: 181 VRGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRS 237 VR D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRS Sbjct: 182 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 241 Query: 238 VETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTV 291 VETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTV Sbjct: 242 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 301 Query: 292 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 351 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 302 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 361 Query: 352 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEF 411 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+F Sbjct: 362 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 421 Query: 412 PPYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKT 471 PPYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKT Sbjct: 422 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 481 Query: 472 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPL 531 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPL Sbjct: 482 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 541 Query: 532 VDXXXXXXXXXXXXXXXPPPRKKSRRR 558 VD PPPRKKSRRR Sbjct: 542 VDALAEHAARLRAEGALPPPRKKSRRR 568 >tr|A2VFJ6|A2VFJ6_MYCTU Tax_Id=348776 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis C] Length = 568 Score = 863 bits (2230), Expect = 0.0 Identities = 442/567 (77%), Positives = 475/567 (83%), Gaps = 10/567 (1%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 +MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPP Sbjct: 3 IMTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPP 62 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARS Sbjct: 63 VSGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARS 121 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 G DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVAD Sbjct: 122 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 181 Query: 181 VRGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRS 237 VR D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRS Sbjct: 182 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 241 Query: 238 VETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTV 291 VETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTV Sbjct: 242 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 301 Query: 292 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST 351 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTST Sbjct: 302 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 361 Query: 352 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEF 411 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+F Sbjct: 362 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 421 Query: 412 PPYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKT 471 PPYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKT Sbjct: 422 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 481 Query: 472 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPL 531 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPL Sbjct: 482 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 541 Query: 532 VDXXXXXXXXXXXXXXXPPPRKKSRRR 558 VD PPPRKKSRRR Sbjct: 542 VDALAEHAARLRAEGALPPPRKKSRRR 568 >tr|Q7TTP7|Q7TTP7_MYCBO Tax_Id=1765 (hemD)SubName: Full=PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM); EC=2.1.1.107;[Mycobacterium bovis] Length = 565 Score = 863 bits (2229), Expect = 0.0 Identities = 442/566 (78%), Positives = 474/566 (83%), Gaps = 10/566 (1%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPPV Sbjct: 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct: 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct: 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 Query: 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct: 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 Query: 239 ETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 ETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct: 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 Query: 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct: 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 Query: 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct: 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 Query: 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTG 472 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTG Sbjct: 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 Query: 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct: 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 Query: 533 DXXXXXXXXXXXXXXXPPPRKKSRRR 558 D PPPRKKSRRR Sbjct: 540 DALAEHAARLRAEGALPPPRKKSRRR 565 >tr|Q6MX34|Q6MX34_MYCTU Tax_Id=1773 (hemD)SubName: Full=PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM); EC=2.1.1.107;[Mycobacterium tuberculosis] Length = 565 Score = 863 bits (2229), Expect = 0.0 Identities = 442/566 (78%), Positives = 474/566 (83%), Gaps = 10/566 (1%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPPV Sbjct: 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct: 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct: 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 Query: 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct: 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 Query: 239 ETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 ETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct: 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 Query: 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct: 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 Query: 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct: 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 Query: 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTG 472 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTG Sbjct: 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 Query: 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct: 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 Query: 533 DXXXXXXXXXXXXXXXPPPRKKSRRR 558 D PPPRKKSRRR Sbjct: 540 DALAEHAARLRAEGALPPPRKKSRRR 565 >tr|C1AKJ1|C1AKJ1_MYCBT Tax_Id=561275 (hemD)SubName: Full=Putative uroporphyrin-III C-methyltransferase; EC=2.1.1.107;[Mycobacterium bovis] Length = 565 Score = 863 bits (2229), Expect = 0.0 Identities = 442/566 (78%), Positives = 474/566 (83%), Gaps = 10/566 (1%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPPV Sbjct: 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct: 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct: 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 Query: 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct: 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 Query: 239 ETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 ETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct: 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 Query: 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct: 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 Query: 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct: 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 Query: 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTG 472 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTG Sbjct: 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 Query: 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct: 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 Query: 533 DXXXXXXXXXXXXXXXPPPRKKSRRR 558 D PPPRKKSRRR Sbjct: 540 DALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A5TZP1|A5TZP1_MYCTA Tax_Id=419947 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase;[Mycobacterium tuberculosis] Length = 565 Score = 863 bits (2229), Expect = 0.0 Identities = 442/566 (78%), Positives = 474/566 (83%), Gaps = 10/566 (1%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPPV Sbjct: 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct: 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct: 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 Query: 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct: 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 Query: 239 ETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 ETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct: 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 Query: 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct: 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 Query: 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct: 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 Query: 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTG 472 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTG Sbjct: 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 Query: 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct: 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 Query: 533 DXXXXXXXXXXXXXXXPPPRKKSRRR 558 D PPPRKKSRRR Sbjct: 540 DALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A1KFY7|A1KFY7_MYCBP Tax_Id=410289 (hemD)SubName: Full=Probable uroporphyrin-III c-methyltransferase hemD; EC=2.1.1.107;[Mycobacterium bovis] Length = 565 Score = 863 bits (2229), Expect = 0.0 Identities = 442/566 (78%), Positives = 474/566 (83%), Gaps = 10/566 (1%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPPV Sbjct: 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct: 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct: 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 Query: 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct: 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 Query: 239 ETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 ETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct: 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 Query: 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct: 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 Query: 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct: 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 Query: 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTG 472 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTG Sbjct: 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 Query: 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct: 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 Query: 533 DXXXXXXXXXXXXXXXPPPRKKSRRR 558 D PPPRKKSRRR Sbjct: 540 DALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A5WJM6|A5WJM6_MYCTF Tax_Id=336982 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis] Length = 565 Score = 863 bits (2229), Expect = 0.0 Identities = 442/566 (78%), Positives = 474/566 (83%), Gaps = 10/566 (1%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPPV Sbjct: 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct: 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct: 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 Query: 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct: 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 Query: 239 ETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 ETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct: 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 Query: 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct: 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 Query: 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct: 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 Query: 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTG 472 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTG Sbjct: 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 Query: 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct: 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 Query: 533 DXXXXXXXXXXXXXXXPPPRKKSRRR 558 D PPPRKKSRRR Sbjct: 540 DALAEHAARLRAEGALPPPRKKSRRR 565 >tr|A4KEJ7|A4KEJ7_MYCTU Tax_Id=395095 SubName: Full=Uroporphyrin-III C-methyltransferase hemD;[Mycobacterium tuberculosis str. Haarlem] Length = 565 Score = 863 bits (2229), Expect = 0.0 Identities = 442/566 (78%), Positives = 474/566 (83%), Gaps = 10/566 (1%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTRGRKPRPGRI +VGSGPGDPG FTDPDVPE V+ALIG DLPPV Sbjct: 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 SG GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct: 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct: 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 Query: 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct: 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 Query: 239 ETTLQGLTDPAILGGTDPA------GPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 ETTLQGLTDPA+LG TDPA GPL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct: 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 Query: 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct: 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 Query: 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct: 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 Query: 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTG 472 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTG Sbjct: 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 Query: 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct: 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 Query: 533 DXXXXXXXXXXXXXXXPPPRKKSRRR 558 D PPPRKKSRRR Sbjct: 540 DALAEHAARLRAEGALPPPRKKSRRR 565 >tr|Q9CB60|Q9CB60_MYCLE Tax_Id=1769 (hemD)SubName: Full=Possible uroporphyrin-III C-methyltransferase;[Mycobacterium leprae] Length = 563 Score = 861 bits (2225), Expect = 0.0 Identities = 441/558 (79%), Positives = 464/558 (83%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 M TRGRK RPGRIT+VG+GPG PG F DPDVPE VLALIG DLPP Sbjct: 6 MTTRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKDLPP 65 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG G EG+ QA P V+S G DIRPALGDPTEVAKTLTAEARS Sbjct: 66 VSGPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMSGGADIRPALGDPTEVAKTLTAEARS 125 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 G DVVRLVAGDP++VDAVIAEVNA+ R++LQIEI+PGL +S VPTYAGLPLGS+HTVAD Sbjct: 126 GVDVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVAD 185 Query: 181 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 VRGDVDWEALAAAPGPLILQATASHLADAA L++H L D TPCVVTA GTTCQQRSVET Sbjct: 186 VRGDVDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVET 245 Query: 241 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA 300 TL+GL D A+L GTD AGPLTGPLVVTIGKTV++RA+LNWWESRALYGWTVLVPRTKDQA Sbjct: 246 TLEGLADSAVLVGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPRTKDQA 305 Query: 301 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 360 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK Sbjct: 306 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 365 Query: 361 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP 420 FGEFGLDARAFSGVKIACVGE+TADRVRAFGISPELVPAGEQSSLGLLDEFPPYDS+FDP Sbjct: 366 FGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSVFDP 425 Query: 421 VNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFT 480 VNRVLLPRADIATETLAEGLR GWEIEDV EMIKTGGFDAVCFT Sbjct: 426 VNRVLLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFT 485 Query: 481 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXX 540 SSSTVRNLVGIAGKPHART+IACIGPKTAETA+EFGLRVDVQPETAAVGPLVD Sbjct: 486 SSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDALAEHVA 545 Query: 541 XXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 546 RLRAEGALPPPRKKSRRR 563 >tr|B8ZT69|B8ZT69_MYCLB Tax_Id=561304 (hemD)SubName: Full=Possible uroporphyrin-III C-methyltransferase;[Mycobacterium leprae] Length = 563 Score = 861 bits (2225), Expect = 0.0 Identities = 441/558 (79%), Positives = 464/558 (83%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 M TRGRK RPGRIT+VG+GPG PG F DPDVPE VLALIG DLPP Sbjct: 6 MTTRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKDLPP 65 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG G EG+ QA P V+S G DIRPALGDPTEVAKTLTAEARS Sbjct: 66 VSGPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMSGGADIRPALGDPTEVAKTLTAEARS 125 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 G DVVRLVAGDP++VDAVIAEVNA+ R++LQIEI+PGL +S VPTYAGLPLGS+HTVAD Sbjct: 126 GVDVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVAD 185 Query: 181 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 VRGDVDWEALAAAPGPLILQATASHLADAA L++H L D TPCVVTA GTTCQQRSVET Sbjct: 186 VRGDVDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVET 245 Query: 241 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA 300 TL+GL D A+L GTD AGPLTGPLVVTIGKTV++RA+LNWWESRALYGWTVLVPRTKDQA Sbjct: 246 TLEGLADSAVLVGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPRTKDQA 305 Query: 301 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 360 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK Sbjct: 306 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 365 Query: 361 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP 420 FGEFGLDARAFSGVKIACVGE+TADRVRAFGISPELVPAGEQSSLGLLDEFPPYDS+FDP Sbjct: 366 FGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSVFDP 425 Query: 421 VNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFT 480 VNRVLLPRADIATETLAEGLR GWEIEDV EMIKTGGFDAVCFT Sbjct: 426 VNRVLLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFT 485 Query: 481 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXX 540 SSSTVRNLVGIAGKPHART+IACIGPKTAETA+EFGLRVDVQPETAAVGPLVD Sbjct: 486 SSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDALAEHVA 545 Query: 541 XXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 546 RLRAEGALPPPRKKSRRR 563 >tr|A0QR19|A0QR19_MYCS2 Tax_Id=246196 (hemD)SubName: Full=Uroporphyrinogen-III synthase; EC=4.2.1.75;[Mycobacterium smegmatis] Length = 610 Score = 811 bits (2096), Expect = 0.0 Identities = 412/565 (72%), Positives = 454/565 (80%), Gaps = 9/565 (1%) Query: 3 TRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVS 62 +R RK +PGRIT+VGSGPGDPG FTDPDVPE+VLAL+G DLPP + Sbjct: 46 SRSRKVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLPPAA 105 Query: 63 GXXXXXXXXXXXXXXXGGPAEGESDQAV------PAVVSSGPDIRPALGDPTEVAKTLTA 116 G ++D+A PAV+ GP++RPALGDP EVAKTL + Sbjct: 106 GPAPAKKNDKADKATDKSDKSDKADKADDAKSDDPAVIPGGPEVRPALGDPAEVAKTLAS 165 Query: 117 EARSGADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAH 176 EAR G +VVRL+AGDP+SVDAVI E+NA+ ++HL EI+PGL T+AVPTYAGLPLGS+H Sbjct: 166 EARHGYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSH 225 Query: 177 TVADVRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQR 236 TVADVRGDVDW ALAAAPGPLIL ATASHL DAARTL+EH L + TP VVTA+GTTCQQR Sbjct: 226 TVADVRGDVDWAALAAAPGPLILHATASHLPDAARTLIEHGLVENTPAVVTANGTTCQQR 285 Query: 237 SVETTLQGLTDPAIL---GGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLV 293 SVETTL GLTD ++ G++ GPLTGPLVVTIGKTV+NRAKLNWWESRALYGWTVLV Sbjct: 286 SVETTLVGLTDKTVVEKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLV 345 Query: 294 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 353 PRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA Sbjct: 346 PRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 405 Query: 354 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPP 413 VRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVP+GEQSSLGLLDEFPP Sbjct: 406 VRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPP 465 Query: 414 YDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGG 473 YD +FDPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTGG Sbjct: 466 YDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGG 525 Query: 474 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD 533 FDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQPETAAVGPLV+ Sbjct: 526 FDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVE 585 Query: 534 XXXXXXXXXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 586 ALAEHAARLRAEGALPPPRKKSRRR 610 >tr|A4T339|A4T339_MYCGI Tax_Id=350054 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium gilvum] Length = 569 Score = 806 bits (2083), Expect = 0.0 Identities = 413/569 (72%), Positives = 448/569 (78%), Gaps = 11/569 (1%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 M RGRK +PGRIT+VGSGPGDPG FTDPDVPE+V AL+G++LPP Sbjct: 1 MSLRGRKNKPGRITFVGSGPGDPGLLTSRARAVLANAALVFTDPDVPEAVRALVGSELPP 60 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVP-----------AVVSSGPDIRPALGDPTE 109 SG G D A AV+ GPD+RPALGDP E Sbjct: 61 PSGPLPPVADAAPKTAAAGADQPASQDAAPADAAKTAKAAEDAVIPGGPDVRPALGDPAE 120 Query: 110 VAKTLTAEARSGADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAG 169 VAKTL EAR+G DVVRLVAGDP+S D+VI EVNA+ ++ L EI+PGL TSAVPTYAG Sbjct: 121 VAKTLAHEARTGVDVVRLVAGDPLSNDSVITEVNALAKTQLSFEIVPGLPGTSAVPTYAG 180 Query: 170 LPLGSAHTVADVRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAH 229 LPLGS+HTVADVRGDVDW ALAAAPGPLIL AT SHL +AARTL+E+ LA++TP VVTA+ Sbjct: 181 LPLGSSHTVADVRGDVDWAALAAAPGPLILHATPSHLPEAARTLIEYGLAESTPAVVTAN 240 Query: 230 GTTCQQRSVETTLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGW 289 GTTCQQRSVETTL GL D A L GT+PAGPLTG LVVTIG+TV+NRAKLNWWESRALYGW Sbjct: 241 GTTCQQRSVETTLAGLLDKAALAGTEPAGPLTGTLVVTIGRTVANRAKLNWWESRALYGW 300 Query: 290 TVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFT 349 TVLVPRTKDQAGEMS+RL +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFT Sbjct: 301 TVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFT 360 Query: 350 STNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLD 409 STNAVRAVWEKF EFGLDARAFSGVKIACVG++TA++VRAFGI+PELVP GEQSSLGLLD Sbjct: 361 STNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAEKVRAFGINPELVPTGEQSSLGLLD 420 Query: 410 EFPPYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMI 469 EFPPYD IFDPVNRVLLPRADIATETLAEGLRE GWEIEDV EMI Sbjct: 421 EFPPYDDIFDPVNRVLLPRADIATETLAEGLRELGWEIEDVTAYRTVRAAPPPAHTREMI 480 Query: 470 KTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVG 529 KTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQPE AAVG Sbjct: 481 KTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVG 540 Query: 530 PLVDXXXXXXXXXXXXXXXPPPRKKSRRR 558 PLV+ PPPRKKSRRR Sbjct: 541 PLVEALAEHAARLRAEGALPPPRKKSRRR 569 >tr|A1T3D4|A1T3D4_MYCVP Tax_Id=350058 SubName: Full=Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium vanbaalenii] Length = 571 Score = 796 bits (2056), Expect = 0.0 Identities = 412/572 (72%), Positives = 452/572 (79%), Gaps = 15/572 (2%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 M RGRK +PGRIT+VGSGPGDPG FTDPDVPE+VL L+G++LPP Sbjct: 1 MSLRGRKGKPGRITFVGSGPGDPGLLTTRARAVLAHAALVFTDPDVPEAVLELVGSELPP 60 Query: 61 VSGXXXXXXXXXXXXXXXG----------GPAEGESDQAVPAVVSSGPDIRPALGDPTEV 110 SG PAEG S A AV+ GPD+RPALGDP EV Sbjct: 61 PSGPLPPVAAGAAPKPADAVVKQDADAAEKPAEG-SKAAEDAVIPGGPDVRPALGDPVEV 119 Query: 111 AKTLTAEARSGADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGL 170 AKTL EAR+G DVVRLVAGDP+S+D+VI E+NA+ ++ L EI+PGL TSAVPTYAGL Sbjct: 120 AKTLATEARTGVDVVRLVAGDPLSIDSVITEINALAKTQLNFEIVPGLPGTSAVPTYAGL 179 Query: 171 PLGSAHTVADVRG-DVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAH 229 PLGS+HTVADVR +VDW ALAAAPGPLIL ATASHL +AARTL+E+ LAD+TP VVTA+ Sbjct: 180 PLGSSHTVADVRDPNVDWAALAAAPGPLILHATASHLPEAARTLIEYGLADSTPAVVTAN 239 Query: 230 GTTCQQRSVETTLQGLTDPAILGG---TDPAGPLTGPLVVTIGKTVSNRAKLNWWESRAL 286 GTTCQQRS+ETTL GL D A+L +PAGPLTG LVVT+G+TV++RAKLNWWESRAL Sbjct: 240 GTTCQQRSIETTLGGLLDKAVLDKPAVAEPAGPLTGTLVVTLGRTVAHRAKLNWWESRAL 299 Query: 287 YGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWV 346 YGWTVLVPRTKDQAGEMS+RL +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWV Sbjct: 300 YGWTVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWV 359 Query: 347 VFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLG 406 VFTSTNAVRAVWEKF EFGLDARAFSGVKIACVG++TA+RVRAFGI+PELVP GEQSSLG Sbjct: 360 VFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLG 419 Query: 407 LLDEFPPYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXX 466 LLDEFPPYD IFDPVNRVLLPRADIATETLAEGLRERGWEIEDV Sbjct: 420 LLDEFPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTR 479 Query: 467 EMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETA 526 EMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQPE A Sbjct: 480 EMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVA 539 Query: 527 AVGPLVDXXXXXXXXXXXXXXXPPPRKKSRRR 558 AVGPLV+ PPPRKKSRRR Sbjct: 540 AVGPLVEALAEHAARLRAEGALPPPRKKSRRR 571 >tr|Q1BE85|Q1BE85_MYCSS Tax_Id=164756 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium sp.] Length = 554 Score = 792 bits (2046), Expect = 0.0 Identities = 410/560 (73%), Positives = 445/560 (79%), Gaps = 18/560 (3%) Query: 4 RGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSG 63 RGRK +PGRIT+VGSGPGDPG FTDPDVPE+VL+L+G LPP SG Sbjct: 8 RGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSG 67 Query: 64 XXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGAD 123 PA+ +QA + + GPDIRPALGDP EVAK L EA+ G D Sbjct: 68 PEPAE------------PADAADEQA-GSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVD 114 Query: 124 VVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG 183 VVRLVAGDP+SVDAVIAEVNA+ +SH EI+PGL T+AVPTYAGLPLGS HTVADVR Sbjct: 115 VVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVADVRD 174 Query: 184 -DVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTL 242 +VDW ALAAAPGPLIL ATASHL DAARTL+E+ LA+TTP VVTA+GTTCQQRSVE+TL Sbjct: 175 PNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTL 234 Query: 243 QGLTDPAILGGTD----PAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKD 298 GL D A L D PA PL GPLVVT+G+TV+NRA+LNWWESRALYGWTVLVPRTKD Sbjct: 235 SGLLDKAALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKD 294 Query: 299 QAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW 358 QAGEMS++L +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW Sbjct: 295 QAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW 354 Query: 359 EKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIF 418 EKF EFGLDARAFSGVKIACVG++TA+RVRAFGI+PELVP GEQSSLGLLDEFPPYD IF Sbjct: 355 EKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIF 414 Query: 419 DPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVC 478 DPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTGGFDAVC Sbjct: 415 DPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVC 474 Query: 479 FTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXX 538 FTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQPE AAVGPLV+ Sbjct: 475 FTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEH 534 Query: 539 XXXXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 535 AARLRAEGALPPPRKKSRRR 554 >tr|A1UAP9|A1UAP9_MYCSK Tax_Id=189918 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium sp.] Length = 554 Score = 792 bits (2046), Expect = 0.0 Identities = 410/560 (73%), Positives = 445/560 (79%), Gaps = 18/560 (3%) Query: 4 RGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSG 63 RGRK +PGRIT+VGSGPGDPG FTDPDVPE+VL+L+G LPP SG Sbjct: 8 RGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSG 67 Query: 64 XXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGAD 123 PA+ +QA + + GPDIRPALGDP EVAK L EA+ G D Sbjct: 68 PEPAE------------PADAADEQA-GSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVD 114 Query: 124 VVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG 183 VVRLVAGDP+SVDAVIAEVNA+ +SH EI+PGL T+AVPTYAGLPLGS HTVADVR Sbjct: 115 VVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVADVRD 174 Query: 184 -DVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTL 242 +VDW ALAAAPGPLIL ATASHL DAARTL+E+ LA+TTP VVTA+GTTCQQRSVE+TL Sbjct: 175 PNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTL 234 Query: 243 QGLTDPAILGGTD----PAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKD 298 GL D A L D PA PL GPLVVT+G+TV+NRA+LNWWESRALYGWTVLVPRTKD Sbjct: 235 SGLLDKAALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKD 294 Query: 299 QAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW 358 QAGEMS++L +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW Sbjct: 295 QAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW 354 Query: 359 EKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIF 418 EKF EFGLDARAFSGVKIACVG++TA+RVRAFGI+PELVP GEQSSLGLLDEFPPYD IF Sbjct: 355 EKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIF 414 Query: 419 DPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVC 478 DPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTGGFDAVC Sbjct: 415 DPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVC 474 Query: 479 FTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXX 538 FTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQPE AAVGPLV+ Sbjct: 475 FTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEH 534 Query: 539 XXXXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 535 AARLRAEGALPPPRKKSRRR 554 >tr|A3PUA5|A3PUA5_MYCSJ Tax_Id=164757 SubName: Full=Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Mycobacterium sp.] Length = 554 Score = 791 bits (2043), Expect = 0.0 Identities = 410/560 (73%), Positives = 445/560 (79%), Gaps = 18/560 (3%) Query: 4 RGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSG 63 RGRK +PGRIT+VGSGPGDPG FTDPDVPE+VL+L+G LPP SG Sbjct: 8 RGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSG 67 Query: 64 XXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGAD 123 PA+ +QA + + GPDIRPALGDP EVAK L EA+ G D Sbjct: 68 PEPAE------------PADAADEQA-GSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVD 114 Query: 124 VVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG 183 VVRLVAGDP+SVDAVIAEVNA+ +SH EI+PGL T+AVPTYAGLPLGS HTVADVR Sbjct: 115 VVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVADVRD 174 Query: 184 -DVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTL 242 +VDW ALAAAPGPLIL ATASHL DAARTL+E+ LA+TTP VVTA+GTTCQQRSVE+TL Sbjct: 175 PNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTL 234 Query: 243 QGLTDPAILGGTD----PAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKD 298 GL D A L D PA PL GPLVVT+G+TV+NRA+LNWWESRALYGWTVLVPRTKD Sbjct: 235 FGLLDKAALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKD 294 Query: 299 QAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW 358 QAGEMS++L +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW Sbjct: 295 QAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW 354 Query: 359 EKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIF 418 EKF EFGLDARAFSGVKIACVG++TA+RVRAFGI+PELVP GEQSSLGLLDEFPPYD IF Sbjct: 355 EKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIF 414 Query: 419 DPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVC 478 DPVNRVLLPRADIATETLAEGLRERGWEIEDV EMIKTGGFDAVC Sbjct: 415 DPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVC 474 Query: 479 FTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXX 538 FTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQPE AAVGPLV+ Sbjct: 475 FTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEH 534 Query: 539 XXXXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 535 AARLRAEGALPPPRKKSRRR 554 >tr|B1MHI4|B1MHI4_MYCA9 Tax_Id=561007 SubName: Full=Possible Uroporphyrin-III C-methyltransferase;[Mycobacterium abscessus] Length = 549 Score = 761 bits (1966), Expect = 0.0 Identities = 393/559 (70%), Positives = 436/559 (77%), Gaps = 12/559 (2%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGN--DLP 59 MTRGRK +PGRI +VGSGPGDPG FTDPDVP++VL L+G+ +LP Sbjct: 1 MTRGRK-KPGRILFVGSGPGDPGLLTVRARAVLTGATVAFTDPDVPQAVLDLVGSAVELP 59 Query: 60 PVSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEAR 119 + G A +D A DIRPALGDP +VAKTL AEAR Sbjct: 60 EPA---------PAKPATGGDEAPAAADNEAAAEPPLTIDIRPALGDPADVAKTLVAEAR 110 Query: 120 SGADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVA 179 SG DVVRLVAGDP+S+D+V+AEV+A+TR+ + EILPGLA+++AVP YAGLP GSAHTVA Sbjct: 111 SGVDVVRLVAGDPLSIDSVLAEVHAVTRTQVAFEILPGLASSTAVPAYAGLPPGSAHTVA 170 Query: 180 DVRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVE 239 DVRGDVDW ALAAAPGPLIL AT +H+ DAA+ L+EH LAD T VTA GTTC QR+VE Sbjct: 171 DVRGDVDWAALAAAPGPLILHATPTHVPDAAKALIEHGLADQTLVAVTAQGTTCAQRTVE 230 Query: 240 TTLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQ 299 TTL L D + DP GP+TG LV+TIG+ V+ R+KLNWWESRALYGWTVLVPRTKDQ Sbjct: 231 TTLASLIDGVPVDANDPHGPMTGALVLTIGRVVAGRSKLNWWESRALYGWTVLVPRTKDQ 290 Query: 300 AGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWE 359 AGEMS++L YGALPVEVPTIAVEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAVWE Sbjct: 291 AGEMSDKLVGYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWE 350 Query: 360 KFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFD 419 KF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPAGEQSSLGLLDEFPPYD +FD Sbjct: 351 KFAEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPAGEQSSLGLLDEFPPYDDVFD 410 Query: 420 PVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCF 479 PVNRVLLPRADIATETLAEGLRERGWEI+DV EMIKTGGFDAVCF Sbjct: 411 PVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPAAQTREMIKTGGFDAVCF 470 Query: 480 TSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXX 539 TSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQPETAAVGPLV+ Sbjct: 471 TSSSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPETAAVGPLVEALAEHA 530 Query: 540 XXXXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 531 ARLRTEGALPPPRKKSRRR 549 >tr|Q49819|Q49819_MYCLE Tax_Id=1769 SubName: Full=CysG;[Mycobacterium leprae] Length = 472 Score = 722 bits (1864), Expect = 0.0 Identities = 366/450 (81%), Positives = 387/450 (86%) Query: 1 MMTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPP 60 M TRGRK RPGRIT+VG+GPG PG F DPDVPE VLALIG DLPP Sbjct: 6 MTTRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKDLPP 65 Query: 61 VSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARS 120 VSG G EG+ QA P V+S G DIRPALGDPTEVAKTLTAEARS Sbjct: 66 VSGPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMSGGADIRPALGDPTEVAKTLTAEARS 125 Query: 121 GADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD 180 G DVVRLVAGDP++VDAVIAEVNA+ R++LQIEI+PGL +S VPTYAGLPLGS+HTVAD Sbjct: 126 GVDVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVAD 185 Query: 181 VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 VRGDVDWEALAAAPGPLILQATASHLADAA L++H L D TPCVVTA GTTCQQRSVET Sbjct: 186 VRGDVDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVET 245 Query: 241 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA 300 TL+GL D A+L GTD AGPLTGPLVVTIGKTV++RA+LNWWESRALYGWTVLVPRTKDQA Sbjct: 246 TLEGLADSAVLVGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPRTKDQA 305 Query: 301 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 360 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK Sbjct: 306 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 365 Query: 361 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP 420 FGEFGLDARAFSGVKIACVGE+TADRVRAFGISPELVPAGEQSSLGLLDEFPPYDS+FDP Sbjct: 366 FGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSVFDP 425 Query: 421 VNRVLLPRADIATETLAEGLRERGWEIEDV 450 VNRVLLPRADIATETLAEGLR GWEIEDV Sbjct: 426 VNRVLLPRADIATETLAEGLRGCGWEIEDV 455 >tr|Q5YP71|Q5YP71_NOCFA Tax_Id=37329 (hemDX)SubName: Full=Putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase;[Nocardia farcinica] Length = 520 Score = 693 bits (1789), Expect = 0.0 Identities = 362/556 (65%), Positives = 405/556 (72%), Gaps = 38/556 (6%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 M+R K PGRI +VGSGPGDP FTDPDV + VLALIG + P Sbjct: 1 MSRATKKHPGRILFVGSGPGDPALLTVRAREVLGRATLAFTDPDVDKGVLALIGTAVEP- 59 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 D P D+RPALG+P EVAKTL AEAR G Sbjct: 60 -----------------------NEDGTSPV------DVRPALGEPAEVAKTLIAEARGG 90 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVR+VAGDP++ D+VI EV A+TRSH+ E+LPGL SAVP+YAG+ LGS HT ADV Sbjct: 91 HDVVRVVAGDPLTTDSVITEVTAVTRSHMVFEVLPGLPNGSAVPSYAGIALGSGHTEADV 150 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RG+VDW ALAAAPGPL+L AT+ HLA+ A LVEH +A TP VT GTT QQR++E T Sbjct: 151 RGEVDWAALAAAPGPLVLHATSGHLAETASALVEHGMAPQTPVAVTVRGTTRQQRTIEAT 210 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L L A L GPLVVTIGK V++R+K++WWESRALYGWTVLVPRTKDQA Sbjct: 211 LATLNSAA--------SELVGPLVVTIGKVVASRSKMSWWESRALYGWTVLVPRTKDQAA 262 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 EMSERL ++GA+P+EVPTIAVEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAVWEKF Sbjct: 263 EMSERLVTHGAIPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKF 322 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGVKIACVGE+TAD+VR+FGI+PELVP+GEQSS GLL +FPPYD +FDPV Sbjct: 323 AEFGLDARAFSGVKIACVGEATADKVRSFGINPELVPSGEQSSEGLLADFPPYDDVFDPV 382 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 NRVLLPRADIATETLAEGLR+RGWEI+DV EMIKTGGFDAV FTS Sbjct: 383 NRVLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRASPPPAETREMIKTGGFDAVLFTS 442 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQPE A VGPLV+ Sbjct: 443 SSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPEVAQVGPLVEALAEHAAR 502 Query: 542 XXXXXXXPPPRKKSRR 557 PPPRKKSRR Sbjct: 503 LRAEGLLPPPRKKSRR 518 >tr|D0L4A2|D0L4A2_GORB4 Tax_Id=526226 SubName: Full=Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase;[Gordonia bronchialis] Length = 577 Score = 687 bits (1774), Expect = 0.0 Identities = 354/577 (61%), Positives = 409/577 (70%), Gaps = 33/577 (5%) Query: 6 RKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGN--------- 56 +K PGRI +VGSGPGDP + DPDVP +V++LIG+ Sbjct: 6 KKSNPGRILFVGSGPGDPDLLTVRARTVIAHATTAYIDPDVPAAVISLIGSAYRAEPTPD 65 Query: 57 -----------DLPPVSGXXXXXXXXXXXXXXXGGPAEGESDQAV---PAVVSSGPD--I 100 D P G + + A P + PD + Sbjct: 66 NRRSTKKPAGADDAPADGVAKDGVAKDGAAKDGAAKDDAANKDAAANGPEATADEPDSPV 125 Query: 101 RPALGDPTEVAKTLTAEARSGADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAA 160 PALGDP EVAKTL A A++G DVVR+V+GDP++ D+V+ EVNA+ R+ + E+LPGL A Sbjct: 126 HPALGDPAEVAKTLVAAAKAGDDVVRVVSGDPLTTDSVLGEVNAVARTSVAFEVLPGLPA 185 Query: 161 TSAVPTYAGLPLGSAHTVADVRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELAD 220 S VP+YAG+PLGS HT ADVRG+VDW ALAAAPGPL+L AT+ HLA+ A L EH +A Sbjct: 186 ASVVPSYAGMPLGSTHTEADVRGEVDWAALAAAPGPLVLHATSGHLAETASALTEHGMAA 245 Query: 221 TTPCVVTAHGTTCQQRSVETTLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNW 280 TP +T +GTTCQQR++E TL L + LTGPL++TIG VS R KL+W Sbjct: 246 QTPVAITVNGTTCQQRTIEATLASLNEQG--------NALTGPLILTIGNVVSARGKLSW 297 Query: 281 WESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVD 340 WESRALYGWTVLVPRTKDQA +MSERL S+GA+P EVPTIAVEPPRSPAQMERAVKGLVD Sbjct: 298 WESRALYGWTVLVPRTKDQAADMSERLVSHGAVPKEVPTIAVEPPRSPAQMERAVKGLVD 357 Query: 341 GRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAG 400 GR+QWVVFTSTNAVRAVWEKF EFGLDARAFSGVKIACVGE+TA+RVR+FGI+PEL+P+G Sbjct: 358 GRYQWVVFTSTNAVRAVWEKFAEFGLDARAFSGVKIACVGEATAERVRSFGINPELIPSG 417 Query: 401 EQSSLGLLDEFPPYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXX 460 EQSSLGLLDEFPPYD +FDPVNR+LLPRADIATETL+EGLRERGWEI+DV Sbjct: 418 EQSSLGLLDEFPPYDDVFDPVNRILLPRADIATETLSEGLRERGWEIDDVTAYRTVRAAP 477 Query: 461 XXXXXXEMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVD 520 EMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVD Sbjct: 478 PPAATREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETATEFGLRVD 537 Query: 521 VQPETAAVGPLVDXXXXXXXXXXXXXXXPPPRKKSRR 557 VQPETA++ LVD PPPRKKSRR Sbjct: 538 VQPETASIPDLVDALAEHAARLRAEGALPPPRKKSRR 574 >tr|C0ZUV6|C0ZUV6_RHOE4 Tax_Id=234621 (cysGA/hemD)SubName: Full=Uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Rhodococcus erythropolis] Length = 520 Score = 682 bits (1761), Expect = 0.0 Identities = 352/557 (63%), Positives = 407/557 (73%), Gaps = 37/557 (6%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RK PGRI +VGSGPGDP FTDPDV + V+AL+G D+ Sbjct: 1 MTRVRKNTPGRILFVGSGPGDPALLTVRARDVLTGAAMAFTDPDVDKGVVALVGIDM--- 57 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 G ++ + D+RPALG+P EVAKTL EA++G Sbjct: 58 ----------------------GRDEETGELIA----DVRPALGEPAEVAKTLVHEAKNG 91 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLV+GDP++ D+VIAEV A+ R+ +Q E+LPGL + SAVP+YAG+ LGS HT ADV Sbjct: 92 HDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSGSAVPSYAGMALGSGHTEADV 151 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RG+VDW ALAAAPGPL+L AT+ HLA+ A LVE+ LA TP +T GTT QQR+VE T Sbjct: 152 RGEVDWAALAAAPGPLVLHATSGHLAETASALVENGLAPQTPAAITVRGTTRQQRTVEAT 211 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L L + L G L+VT+GK V+ R K++WWESRALYGWTVLVPRTKDQAG Sbjct: 212 LATLNEAG--------SELVGSLIVTVGKVVAQRNKMSWWESRALYGWTVLVPRTKDQAG 263 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 EMS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAVWEKF Sbjct: 264 EMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAVWEKF 323 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGVKIAC+GE+TA +VR+FGI+PEL+P GEQSS GLL EF PYD +FDPV Sbjct: 324 EEFGLDARAFSGVKIACIGEATAAKVRSFGINPELIPTGEQSSEGLLAEFAPYDDVFDPV 383 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 NRVLLPRADIATETLAEGLRERGWEI+DV EMIKTGGFDAVCFTS Sbjct: 384 NRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTS 443 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQPET+ VGPLV+ Sbjct: 444 SSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETSQVGPLVEALAEHAAR 503 Query: 542 XXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 504 LRAEGALPPPRKKSRRR 520 >tr|C3JK03|C3JK03_RHOER Tax_Id=596309 (hemD)SubName: Full=Uroporphyrinogen-III synthase; EC=4.2.1.75;[Rhodococcus erythropolis SK121] Length = 520 Score = 682 bits (1761), Expect = 0.0 Identities = 352/557 (63%), Positives = 407/557 (73%), Gaps = 37/557 (6%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RK PGRI +VGSGPGDP FTDPDV + V+AL+G D+ Sbjct: 1 MTRVRKNTPGRILFVGSGPGDPALLTVRARDVLTGAAMAFTDPDVDKGVVALVGIDM--- 57 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 G ++ + D+RPALG+P EVAKTL EA++G Sbjct: 58 ----------------------GRDEETGELIA----DVRPALGEPAEVAKTLVHEAKNG 91 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLV+GDP++ D+VIAEV A+ R+ +Q E+LPGL + SAVP+YAG+ LGS HT ADV Sbjct: 92 HDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSGSAVPSYAGMALGSGHTEADV 151 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RG+VDW ALAAAPGPL+L AT+ HLA+ A LVE+ LA TP +T GTT QQR+VE T Sbjct: 152 RGEVDWAALAAAPGPLVLHATSGHLAETASALVENGLAPQTPAAITVRGTTRQQRTVEAT 211 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L L + L G L+VT+GK V+ R K++WWESRALYGWTVLVPRTKDQAG Sbjct: 212 LATLNEAG--------SELVGSLIVTVGKVVAQRNKMSWWESRALYGWTVLVPRTKDQAG 263 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 EMS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAVWEKF Sbjct: 264 EMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAVWEKF 323 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGVKIAC+GE+TA +VR+FGI+PEL+P GEQSS GLL EF PYD +FDPV Sbjct: 324 EEFGLDARAFSGVKIACIGEATAAKVRSFGINPELIPTGEQSSEGLLAEFAPYDDVFDPV 383 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 NRVLLPRADIATETLAEGLRERGWEI+DV EMIKTGGFDAVCFTS Sbjct: 384 NRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTS 443 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQPET+ VGPLV+ Sbjct: 444 SSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETSQVGPLVEALAEHAAR 503 Query: 542 XXXXXXXPPPRKKSRRR 558 PPPRKKSRRR Sbjct: 504 LRAEGALPPPRKKSRRR 520 >tr|Q0SF28|Q0SF28_RHOSR Tax_Id=101510 SubName: Full=Probable uroporphiryn-III C-methyltransferase; EC=2.1.1.107;[Rhodococcus sp.] Length = 521 Score = 681 bits (1758), Expect = 0.0 Identities = 356/557 (63%), Positives = 404/557 (72%), Gaps = 37/557 (6%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 M+R RK PGRI +VGSGPGDP FTDPDV + V L+G DL Sbjct: 1 MSRVRKNTPGRILFVGSGPGDPALLTVHARDVLAAATLAFTDPDVDKGVTVLVGTDL--- 57 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 G AE A ++RPALG+P EVAKTL EAR+G Sbjct: 58 -----------------GVDAETGEPLA---------EVRPALGEPAEVAKTLVHEARNG 91 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLV+GDP++ D+VIAEV A+ R+ +Q E+LPGL + SAVP+YAG+ LGS HT ADV Sbjct: 92 HDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSASAVPSYAGMALGSGHTEADV 151 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RG+VDW ALAAAPGPL+L AT+ HLA+ A LVEH LA TP +T GTT QQR+VE T Sbjct: 152 RGEVDWAALAAAPGPLVLHATSGHLAETASALVEHGLAPQTPAAITVRGTTRQQRTVEAT 211 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L L + L G LVVT+GK V+ R K++WWESRALYGW VLVPRTKDQAG Sbjct: 212 LATLNEAG--------SELVGSLVVTVGKVVAQRNKMSWWESRALYGWKVLVPRTKDQAG 263 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 EMS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAVWEKF Sbjct: 264 EMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAVWEKF 323 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGVKIAC+GE+TA +VR+FGI+PELVP+GEQSS GLL EF PYD +FDPV Sbjct: 324 EEFGLDARAFSGVKIACIGEATAAKVRSFGINPELVPSGEQSSEGLLAEFAPYDDVFDPV 383 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 NRVLLPRADIATETLAEGLRERGWEI+DV EMIKTGGFDAVCFTS Sbjct: 384 NRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTS 443 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQPETA VGPLV+ Sbjct: 444 SSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETAQVGPLVEALAEHAAR 503 Query: 542 XXXXXXXPPPRKKSRRR 558 PPPRKKSR R Sbjct: 504 LRAEGALPPPRKKSRAR 520 >tr|C1AZ42|C1AZ42_RHOOB Tax_Id=632772 (cysGA/hemD)SubName: Full=Putative uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Rhodococcus opacus] Length = 521 Score = 680 bits (1755), Expect = 0.0 Identities = 355/557 (63%), Positives = 404/557 (72%), Gaps = 37/557 (6%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 M+R RK PGRI +VGSGPGDP FTDPDV + V L+G DL Sbjct: 1 MSRVRKNTPGRILFVGSGPGDPALLTVHARDVLAAATLAFTDPDVDKGVTVLVGTDL--- 57 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 G AE A ++RPALG+P EVAKTL EA++G Sbjct: 58 -----------------GVDAETGEPLA---------EVRPALGEPAEVAKTLVHEAKNG 91 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 DVVRLV+GDP++ D+VIAEV A+ R+ +Q E+LPGL + SAVP+YAG+ LGS HT ADV Sbjct: 92 HDVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSASAVPSYAGMALGSGHTEADV 151 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RG+VDW ALAAAPGPL+L AT+ HLA+ A LVEH LA TP +T GTT QQR+VE T Sbjct: 152 RGEVDWAALAAAPGPLVLHATSGHLAETASALVEHGLAPQTPAAITVRGTTRQQRTVEAT 211 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L L + L G LVVT+GK V+ R K++WWESRALYGW VLVPRTKDQAG Sbjct: 212 LATLNEAG--------SELVGSLVVTVGKVVAQRNKMSWWESRALYGWKVLVPRTKDQAG 263 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 EMS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAVWEKF Sbjct: 264 EMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAVWEKF 323 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGVKIAC+GE+TA +VR+FGI+PELVP+GEQSS GLL EF PYD +FDPV Sbjct: 324 EEFGLDARAFSGVKIACIGEATAAKVRSFGINPELVPSGEQSSEGLLAEFAPYDDVFDPV 383 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 NRVLLPRADIATETLAEGLRERGWEI+DV EMIKTGGFDAVCFTS Sbjct: 384 NRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTS 443 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQPETA VGPLV+ Sbjct: 444 SSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETAQVGPLVEALAEHAAR 503 Query: 542 XXXXXXXPPPRKKSRRR 558 PPPRKKSR R Sbjct: 504 LRAEGALPPPRKKSRAR 520 >tr|C2AL33|C2AL33_TSUPA Tax_Id=521096 SubName: Full=Uroporphyrinogen-III C-methyltransferase; uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Tsukamurella paurometabola DSM 20162] Length = 567 Score = 680 bits (1755), Expect = 0.0 Identities = 354/554 (63%), Positives = 409/554 (73%), Gaps = 18/554 (3%) Query: 4 RGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSG 63 RG+ PGRIT+VGSGPGDPG +TDPDVP +VL ++G +LP Sbjct: 29 RGKATAPGRITFVGSGPGDPGLLTLRAQQTIAQARTVYTDPDVPATVLEMVGAELP---- 84 Query: 64 XXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGAD 123 PA+G +A PA + + PALG+P EVAKTL +AR G D Sbjct: 85 ---VEPIETDADAPAAEPAKGR--KAEPAFRNPAT-VAPALGEPAEVAKTLLTQARHGQD 138 Query: 124 VVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG 183 VVRLVAGDPMS DAV+AE++A+ R+ + E++PGL+ +AVP YAG+ LGSAHTVADVRG Sbjct: 139 VVRLVAGDPMSSDAVLAEIHAVARTQIAFEVIPGLSTATAVPAYAGMALGSAHTVADVRG 198 Query: 184 DVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQ 243 +VDW ALAAAP PL+L ATA HLADAA LVE+ LA TP VT G+TC+Q++++ TL Sbjct: 199 EVDWAALAAAPSPLVLGATAEHLADAASALVENGLAPQTPVAVTTQGSTCKQKTLDATLA 258 Query: 244 GLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEM 303 L + A AG L GPLV+T+GK V R+KL+WWESRALYGWTVLVPRTKDQA +M Sbjct: 259 TLNEVA-------AG-LPGPLVITVGKVVGTRSKLSWWESRALYGWTVLVPRTKDQAADM 310 Query: 304 SERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGE 363 S RL +GA+P+EVPTIAVEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAVWEKF E Sbjct: 311 SNRLRGHGAIPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFTE 370 Query: 364 FGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPVNR 423 FGLDARAFSGVKIACVGE TA +VRAFGI PEL+P GEQSSLG+L+ FPP+D +FDPVNR Sbjct: 371 FGLDARAFSGVKIACVGEQTAAKVRAFGIEPELLPTGEQSSLGMLEVFPPFDDVFDPVNR 430 Query: 424 VLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSS 483 VLLPRADIATETLAEGLR+RGWEI+DV EMIKTG FDAVCFTSSS Sbjct: 431 VLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRAAPPPASTREMIKTGDFDAVCFTSSS 490 Query: 484 TVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXX 543 TVRNLVGIAGKPH+RTI+ACIGPKTAETA EFGLRVDVQPETA+V LV+ Sbjct: 491 TVRNLVGIAGKPHSRTIVACIGPKTAETAIEFGLRVDVQPETASVEDLVEALAAHASRLR 550 Query: 544 XXXXXPPPRKKSRR 557 PPPRKK RR Sbjct: 551 AEGTLPPPRKKPRR 564 >tr|C6WNG1|C6WNG1_ACTMD Tax_Id=446462 SubName: Full=Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase;[Actinosynnema mirum] Length = 510 Score = 629 bits (1623), Expect = e-178 Identities = 333/557 (59%), Positives = 389/557 (69%), Gaps = 49/557 (8%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RK PGR+ +VGSGPGD G TDPDVP V+AL Sbjct: 1 MTRARKT-PGRVAFVGSGPGDTGLLTVRARDLLGKAELVVTDPDVPAEVVAL-------- 51 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 V G ++RPA+G+P +VAK L AEA++G Sbjct: 52 --------------------------------VPDGVEVRPAVGEPADVAKDLVAEAKNG 79 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 A VVRLVAGDP+++D+V+ E +A++++ + +++PG+ A +AVP YAG+ LG+ HT ADV Sbjct: 80 AAVVRLVAGDPLTLDSVVKEAHAVSKTTIAFDVVPGVPAGTAVPAYAGVALGAVHTEADV 139 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RG VDW LA+A G L+L AT HLA+AA +LVEH LA TP VTA GT QR+V+TT Sbjct: 140 RGAVDWAGLASATGTLVLHATGGHLAEAASSLVEHGLAPQTPVAVTADGTGFSQRTVDTT 199 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L L A G L+GPLVVT+G V+NR KL+WWESRALYGW VLVPRTK+QAG Sbjct: 200 LASLAADA--------GELSGPLVVTVGSAVANRPKLSWWESRALYGWRVLVPRTKEQAG 251 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 MS+RL S+GA+PVEVPTI+VEPPRSPAQMER+VKGLVDGR+QWVVFTSTNAVRAVWEKF Sbjct: 252 AMSDRLHSHGAIPVEVPTISVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAVWEKF 311 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGVKIACVGE+TA +VR FGI PELVP+GEQSS GLL +FPPYD I DPV Sbjct: 312 REFGLDARAFSGVKIACVGEATAAKVRGFGIIPELVPSGEQSSEGLLADFPPYDDILDPV 371 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 +RVLLPRADIATETLA GLR+RGWEI+DV EMIK+GGFDAVCFTS Sbjct: 372 DRVLLPRADIATETLAAGLRDRGWEIDDVTAYRTVRAAPPPADTREMIKSGGFDAVCFTS 431 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHART++ACIGP+TAETA EFGLRVDVQPE A V LVD Sbjct: 432 SSTVRNLVGIAGKPHARTLVACIGPQTAETAREFGLRVDVQPEDANVPALVDALAQHAAR 491 Query: 542 XXXXXXXPPPRKKSRRR 558 PPPRK R R Sbjct: 492 LRAEGALPPPRKTKRLR 508 >tr|A4FPY2|A4FPY2_SACEN Tax_Id=405948 (hemD)SubName: Full=Uroporphyrinogen III synthase/methyltransferase; EC=2.1.1.107; EC=4.2.1.75;[Saccharopolyspora erythraea] Length = 510 Score = 614 bits (1584), Expect = e-174 Identities = 326/557 (58%), Positives = 376/557 (67%), Gaps = 49/557 (8%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RK PGRI +VGSGPGD G TDPDVP ++ L Sbjct: 1 MTRARKT-PGRIAFVGSGPGDAGLLTVRARHVITSASLVVTDPDVPADIVGL-------- 51 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 + G ++RPA+GDP +VA L EA++G Sbjct: 52 --------------------------------AAEGAEVRPAVGDPADVALDLANEAKTG 79 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 VVRLVAGDP++ DAV+ EV A+ ++ + +I+PG+ A SAVP YAG+ LG+ H DV Sbjct: 80 RPVVRLVAGDPLTADAVVREVQAVAKTDVAFDIVPGVPAGSAVPAYAGVALGAVHAEVDV 139 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 RGDVDW +LA PG L+L +HLA+AA LVEH A TP VTA GTT QQR+++TT Sbjct: 140 RGDVDWASLAKVPGALVLHTAGTHLAEAASALVEHGRAAQTPVAVTASGTTVQQRTIDTT 199 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L L A G L G LVVTIG VS R L+WWESRALYGW VLVPRTK+QAG Sbjct: 200 LASLAADA--------GELQGQLVVTIGDVVSERNSLSWWESRALYGWKVLVPRTKEQAG 251 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 MSERL S+GA+ EVPTI+VEPPRSPAQMERAVKGLVDGR+QWVVFTSTNAVRAVWEKF Sbjct: 252 SMSERLWSHGAVSHEVPTISVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKF 311 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGVKIACVGE+TA++VR+FGI+PELVP+GEQSS GLL +FPP+D I DPV Sbjct: 312 REFGLDARAFSGVKIACVGEATAEKVRSFGINPELVPSGEQSSEGLLQDFPPHDDILDPV 371 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 +RVLLPRADIATETLA GLRERGWEI+DV EMIKTGGFDAVCFTS Sbjct: 372 DRVLLPRADIATETLAAGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTS 431 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 +STVRNLVGIAGKPHART++ACIGP TAETA EFGLRVDVQPE + LVD Sbjct: 432 ASTVRNLVGIAGKPHARTLVACIGPSTAETAKEFGLRVDVQPEVPQIPVLVDALAEHAAR 491 Query: 542 XXXXXXXPPPRKKSRRR 558 PPP+K R R Sbjct: 492 LRAEGALPPPKKAKRAR 508 >tr|C7MT08|C7MT08_SACVD Tax_Id=471857 SubName: Full=Uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase;[Saccharomonospora viridis] Length = 516 Score = 606 bits (1562), Expect = e-171 Identities = 321/558 (57%), Positives = 380/558 (68%), Gaps = 50/558 (8%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RK GR+ +VGSGPGD G TDPDVP VLA G + Sbjct: 1 MTRARKTT-GRVAFVGSGPGDAGLLTVRARDLLAKADLVVTDPDVPAGVLAYAGPEA--- 56 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 ++RPA+G+P +VAK L EA++G Sbjct: 57 -------------------------------------EVRPAVGEPGDVAKDLATEAKAG 79 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 V+RL +GDP++ AVIAEV A++R++ +++PG+ A +A P YAG+ LG T D+ Sbjct: 80 RLVLRLTSGDPLTQQAVIAEVQAVSRTNAVFDVVPGVPAGTATPAYAGIALGGVRTEVDL 139 Query: 182 R-GDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET 240 R G+VDW LA+APG ++L AT+SHLA+AA LVEH ++D TP VT++GT QR++++ Sbjct: 140 RSGEVDWAKLASAPGAIVLHATSSHLAEAASALVEHGMSDQTPVAVTSNGTINTQRTLDS 199 Query: 241 TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA 300 TL L A G L GPLVVTIG+ VSNR KL+WWESRALYGW VLVPRTK+QA Sbjct: 200 TLASLAADA--------GELVGPLVVTIGEPVSNRQKLSWWESRALYGWKVLVPRTKEQA 251 Query: 301 GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK 360 G+M+ER+ S+GA P EVPTI+VEPPRSPAQMERAVKGLVDGR+QW+VFTS NAVRAVWEK Sbjct: 252 GDMAERILSHGATPHEVPTISVEPPRSPAQMERAVKGLVDGRYQWLVFTSANAVRAVWEK 311 Query: 361 FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP 420 F EFGLDARAFSGVKIACVGE+TADRVR+FGI PELVP GEQSS GLL EFPPYD + DP Sbjct: 312 FNEFGLDARAFSGVKIACVGEATADRVRSFGIIPELVPKGEQSSEGLLQEFPPYDDVLDP 371 Query: 421 VNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFT 480 VNRVLLPRADIATE L+ GL+ERGWE++DV EMIKTGGFDAVCFT Sbjct: 372 VNRVLLPRADIATEILSAGLQERGWEVDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFT 431 Query: 481 SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXX 540 SSSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDV+PE LVD Sbjct: 432 SSSTVRNLVGIAGKPHARTLVACIGPKTAETATEFGLRVDVRPEQPNAVMLVDALAEHAA 491 Query: 541 XXXXXXXXPPPRKKSRRR 558 PPPRK R R Sbjct: 492 KLRAEGALPPPRKAKRTR 509 >tr|C8XAG5|C8XAG5_NAKMY Tax_Id=479431 SubName: Full=Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase;[Nakamurella multipartita] Length = 506 Score = 572 bits (1473), Expect = e-161 Identities = 307/557 (55%), Positives = 368/557 (66%), Gaps = 51/557 (9%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RKP GRI +VG+GPGDPG TDPDVP + AL G Sbjct: 1 MTRARKP-VGRIAFVGAGPGDPGLLTMRAAHALDAASLVVTDPDVPADITALAGE----- 54 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 +++PA+G+P EVAK L A A++G Sbjct: 55 ------------------------------------AEVKPAVGEPAEVAKALVAAAKNG 78 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 VVRLVAGD ++ D V+ E+ +++RS + +++PGL+AT AV +Y+G+ +GS HTVADV Sbjct: 79 QFVVRLVAGDVLTADPVVKELQSVSRSAVLFDVIPGLSAT-AVASYSGIAVGSVHTVADV 137 Query: 182 RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT 241 R DW LAAAPG L+LQA++ HLAD A L + +A TP VT+ T QR+V+ T Sbjct: 138 RSTSDWPRLAAAPGTLLLQASSGHLADTAALLAQSGMAGETPASVTSGATLPTQRTVDGT 197 Query: 242 LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG 301 L A L G G +TGPLVVT+G ++ R +L+WWESRALYGW VL+P+TKD A Sbjct: 198 L------ATLDGI--GGDMTGPLVVTVGAGITQRNRLSWWESRALYGWRVLIPQTKDPAE 249 Query: 302 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF 361 EM E L +GA+P VPT+AVEPPR+PAQMERAVKGLVDGR+QW+VFTS N+VRAVWEKF Sbjct: 250 EMLELLRLHGAIPQRVPTVAVEPPRTPAQMERAVKGLVDGRYQWIVFTSINSVRAVWEKF 309 Query: 362 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV 421 EFGLDARAFSGV+IACV +T D VRA GI PEL+ A +QSS GLL FP YD I DPV Sbjct: 310 VEFGLDARAFSGVRIACVDSATGDAVRALGIVPELISADQQSSAGLLSTFPEYDDILDPV 369 Query: 422 NRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTS 481 +RVLLPRADIATETLAEGLRERGWEI+DV E IKTGGFDAVCFTS Sbjct: 370 DRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPAAPIREAIKTGGFDAVCFTS 429 Query: 482 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXX 541 SSTVRNLVGIAGKPHAR+++AC+GPKTAETA EFGLRVDVQPE A +G LV+ Sbjct: 430 SSTVRNLVGIAGKPHARSLVACLGPKTAETAREFGLRVDVQPEVAELGALVEALAEHASR 489 Query: 542 XXXXXXXPPPRKKSRRR 558 PPPRK RRR Sbjct: 490 LRAEGALPPPRKSPRRR 506 >tr|C0U8E1|C0U8E1_9ACTO Tax_Id=526225 SubName: Full=Uroporphyrinogen-III C-methyltransferase; uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Geodermatophilus obscurus DSM 43160] Length = 516 Score = 531 bits (1368), Expect = e-149 Identities = 292/540 (54%), Positives = 353/540 (65%), Gaps = 50/540 (9%) Query: 2 MTRGRKPR---PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDL 58 MTR RK G + +VG+GPGDPG D VP ++ + D Sbjct: 1 MTRFRKQNGGATGTVVFVGAGPGDPGMLTARATAALAEAHTVLVDTAVPPAIAEAVRADR 60 Query: 59 PPVSGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEA 118 P + ++ PA G+P EVAK A A Sbjct: 61 PEL-------------------------------------ELTPATGEPAEVAKAAVAAA 83 Query: 119 RSGADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTV 178 ++G VVRLVAGDP + DAV+ EV A+ R+ + +++PG+A+ +AVP +AG+ LG Sbjct: 84 KAGGTVVRLVAGDPFTSDAVVKEVLAVGRTSVGFDVVPGVASQTAVPAFAGVALGGTSLT 143 Query: 179 ADVRG-DVDWEALAAAP----GPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTC 233 AD+RG + D ALAAA PL+LQ A L DAA LVE L+ +T VVT G+ Sbjct: 144 ADLRGGEADLAALAAATKRLDAPLVLQGNAEDLPDAAARLVEGGLSGSTAVVVTTGGSGT 203 Query: 234 QQRSVETTLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLV 293 QRSV L + + G D ++GP+V T+G V RA+L+WWESR L+GW VLV Sbjct: 204 GQRSVVAKLAAVAEKT--AGLDA---VSGPVVATVGSAVDKRARLSWWESRPLFGWRVLV 258 Query: 294 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 353 PRTKDQAGEMS+RL +YGA+PVEVPTIAVEPPRSPAQM+RA+KGLV GR+ W+VFTS NA Sbjct: 259 PRTKDQAGEMSDRLRAYGAVPVEVPTIAVEPPRSPAQMDRAIKGLVTGRYGWIVFTSVNA 318 Query: 354 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPP 413 V+AV EKF E GLDARAF+GVK+ACVGESTAD VRAFGI PELVP G+QSS GLL +FP Sbjct: 319 VKAVREKFVELGLDARAFAGVKVACVGESTADAVRAFGIVPELVPTGQQSSEGLLADFPE 378 Query: 414 YDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGG 473 YD + DP++RVLLPRADIATETLA GL+ERGWEI+DV E IK GG Sbjct: 379 YDDVLDPIDRVLLPRADIATETLAAGLKERGWEIDDVTAYRTVRAAPPPAPVREAIKGGG 438 Query: 474 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD 533 FDAVCFTSSSTVRNLVGIAGKPHA+T++A IGP+TA TA EFGLRVDVQP TAAVGPLVD Sbjct: 439 FDAVCFTSSSTVRNLVGIAGKPHAKTVVAVIGPQTAATAQEFGLRVDVQPGTAAVGPLVD 498 >tr|C4RC05|C4RC05_9ACTO Tax_Id=219305 SubName: Full=Uroporphyrinogen III synthase HEM4;[Micromonospora sp. ATCC 39149] Length = 526 Score = 503 bits (1295), Expect = e-140 Identities = 288/536 (53%), Positives = 334/536 (62%), Gaps = 49/536 (9%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RKP GRI +VG+GPGDPG D VPES+L Sbjct: 1 MTRTRKP-VGRIAFVGAGPGDPGLLTRRAHDALVDADQVVYDRGVPESLL---------- 49 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 AV A S PA G P +VAK L + ARSG Sbjct: 50 --------------------------DAVRAQAKSDAQFSPAEGVPGDVAKVLISAARSG 83 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 + V LVAGDP D+V+ EV A+ R+ E++PG+ V TYAG+PL T ADV Sbjct: 84 LNAVHLVAGDPFGHDSVVKEVQAVARTAAHFEVVPGVGQAEGVATYAGVPLPGVRTAADV 143 Query: 182 RG--DVDWEALAAAPG--PLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRS 237 +D++ALAAA G L L A LA L+ + TT VT GT Q + Sbjct: 144 EDVTTLDFDALAAAVGRGSLALAVDAGDLAAIRDGLLAAGVDGTTGVGVTGDGTGETQYT 203 Query: 238 VETTLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTK 297 +T+ A+ TG +V+TIG+ V R K++WWE+R LYGW VLVPRTK Sbjct: 204 TTSTVDSFVAAAL--------GFTGRVVLTIGEGVGQRDKMSWWENRPLYGWKVLVPRTK 255 Query: 298 DQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 357 +QAG MS RL +YGA+P EVPTIAVEPPR+PAQMERAVKGLVDGR+ WVVFTS NAVRAV Sbjct: 256 EQAGAMSARLRAYGAIPCEVPTIAVEPPRTPAQMERAVKGLVDGRYAWVVFTSVNAVRAV 315 Query: 358 WEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSI 417 WEKF E GLDAR F GVKIAC+GE+TAD VRAFGI PELVPAGEQSS GLL EF P+D I Sbjct: 316 WEKFAEHGLDARHFGGVKIACIGEATADAVRAFGIQPELVPAGEQSSEGLLAEFSPHDEI 375 Query: 418 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAV 477 DPV RVLLPRADIATETLA GL ERGWE++DV + IK+GGFDAV Sbjct: 376 LDPVGRVLLPRADIATETLAAGLTERGWEVDDVTAYRTVRAAPPPAEIRDAIKSGGFDAV 435 Query: 478 CFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD 533 FTSSSTVRNLVGIAGKPHART++A IGPKTAETA EFGLRVDVQP+ A+V LV+ Sbjct: 436 LFTSSSTVRNLVGIAGKPHARTVVAVIGPKTAETATEFGLRVDVQPQHASVPDLVE 491 >tr|Q8FSE4|Q8FSE4_COREF Tax_Id=152794 SubName: Full=Putative uroporphyrin-III C-methyltransferase CysG;[Corynebacterium efficiens] Length = 673 Score = 500 bits (1288), Expect = e-139 Identities = 269/551 (48%), Positives = 338/551 (61%), Gaps = 10/551 (1%) Query: 10 PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXX 69 PG++ +VG+GPG+P TD V SV + +LP Sbjct: 128 PGKVIFVGAGPGNPDLLTVRAREVLGKTVRAVTDAQVLSSVRDFVAAELPVPEDKLKAAE 187 Query: 70 XXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVA 129 PA ++ I DP E+A+ L + G DV+RLV Sbjct: 188 EEYERLCAEAKEGGARRKPPRPAPPTAAEIIEVDHADPEEIARILAEQLAKGGDVIRLVT 247 Query: 130 GDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG-DVDWE 188 G+P+S D+ +AE+ A++ + + +++PG++ VP +AG+ LGS +T DV G DVDW+ Sbjct: 248 GNPLSSDSTLAEITAVSEAGMSFQVVPGMSLPGTVPAFAGIALGSTYTETDVSGEDVDWD 307 Query: 189 ALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDP 248 LA+AP PL+LQA A +LA A L +L P VT +GTT QR+ +TTL L Sbjct: 308 QLASAPQPLVLQARAENLATIATELKTRDLPLELPVSVTVNGTTRMQRTYDTTLGALAKL 367 Query: 249 AILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLT 308 L GPLVVT+G+ VS+R K +WWE+RALYGW VLVPR K QA MS RL Sbjct: 368 D--------AELPGPLVVTLGEGVSDREKYSWWENRALYGWRVLVPRAKPQAAAMSARLA 419 Query: 309 SYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDA 368 S+GA+P EVPTI+VEPPR+PAQMERA+KG+V+GR+QWVV TS NAVRAVW+ EFGLD+ Sbjct: 420 SHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVRAVWDMITEFGLDS 479 Query: 369 RAFSGVKIACVGESTADRVRAFGISPELV-PAGEQSSLGLLDEFPPYDSIFDPVNRVLLP 427 R+F+GV+IA VGE TA +RA GI+PEL+ P Q++ G++D FP Y DPV RVLLP Sbjct: 480 RSFAGVRIAAVGEKTAAEIRALGITPELLPPRNRQNAQGIVDVFPEYIEELDPVGRVLLP 539 Query: 428 RADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRN 487 RADIAT+ L +GL GWE++DV +MIKTGGFDAVCFTSSSTVRN Sbjct: 540 RADIATDVLVDGLVALGWEVDDVVAYRTVRAAPPSADIRDMIKTGGFDAVCFTSSSTVRN 599 Query: 488 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXX 547 LVGIAGKPH RTIIACIGP TA+TA E GLRVDV PE A V LVD Sbjct: 600 LVGIAGKPHPRTIIACIGPMTADTARELGLRVDVMPEIAEVPDLVDALADHVADLRAKGE 659 Query: 548 XPPPRKKSRRR 558 PPPRKK RRR Sbjct: 660 LPPPRKKRRRR 670 >tr|C8NSF6|C8NSF6_COREF Tax_Id=196164 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; EC=2.1.1.107;[Corynebacterium efficiens YS-314] Length = 626 Score = 500 bits (1288), Expect = e-139 Identities = 269/551 (48%), Positives = 338/551 (61%), Gaps = 10/551 (1%) Query: 10 PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXX 69 PG++ +VG+GPG+P TD V SV + +LP Sbjct: 81 PGKVIFVGAGPGNPDLLTVRAREVLGKTVRAVTDAQVLSSVRDFVAAELPVPEDKLKAAE 140 Query: 70 XXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVA 129 PA ++ I DP E+A+ L + G DV+RLV Sbjct: 141 EEYERLCAEAKEGGARRKPPRPAPPTAAEIIEVDHADPEEIARILAEQLAKGGDVIRLVT 200 Query: 130 GDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG-DVDWE 188 G+P+S D+ +AE+ A++ + + +++PG++ VP +AG+ LGS +T DV G DVDW+ Sbjct: 201 GNPLSSDSTLAEITAVSEAGMSFQVVPGMSLPGTVPAFAGIALGSTYTETDVSGEDVDWD 260 Query: 189 ALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDP 248 LA+AP PL+LQA A +LA A L +L P VT +GTT QR+ +TTL L Sbjct: 261 QLASAPQPLVLQARAENLATIATELKTRDLPLELPVSVTVNGTTRMQRTYDTTLGALAKL 320 Query: 249 AILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLT 308 L GPLVVT+G+ VS+R K +WWE+RALYGW VLVPR K QA MS RL Sbjct: 321 D--------AELPGPLVVTLGEGVSDREKYSWWENRALYGWRVLVPRAKPQAAAMSARLA 372 Query: 309 SYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDA 368 S+GA+P EVPTI+VEPPR+PAQMERA+KG+V+GR+QWVV TS NAVRAVW+ EFGLD+ Sbjct: 373 SHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVRAVWDMITEFGLDS 432 Query: 369 RAFSGVKIACVGESTADRVRAFGISPELV-PAGEQSSLGLLDEFPPYDSIFDPVNRVLLP 427 R+F+GV+IA VGE TA +RA GI+PEL+ P Q++ G++D FP Y DPV RVLLP Sbjct: 433 RSFAGVRIAAVGEKTAAEIRALGITPELLPPRNRQNAQGIVDVFPEYIEELDPVGRVLLP 492 Query: 428 RADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRN 487 RADIAT+ L +GL GWE++DV +MIKTGGFDAVCFTSSSTVRN Sbjct: 493 RADIATDVLVDGLVALGWEVDDVVAYRTVRAAPPSADIRDMIKTGGFDAVCFTSSSTVRN 552 Query: 488 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXX 547 LVGIAGKPH RTIIACIGP TA+TA E GLRVDV PE A V LVD Sbjct: 553 LVGIAGKPHPRTIIACIGPMTADTARELGLRVDVMPEIAEVPDLVDALADHVADLRAKGE 612 Query: 548 XPPPRKKSRRR 558 PPPRKK RRR Sbjct: 613 LPPPRKKRRRR 623 >tr|C4LLC0|C4LLC0_CORK4 Tax_Id=645127 SubName: Full=Uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase; EC=4.2.1.75;[Corynebacterium kroppenstedtii] Length = 552 Score = 500 bits (1287), Expect = e-139 Identities = 271/553 (49%), Positives = 343/553 (62%), Gaps = 13/553 (2%) Query: 10 PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXX 69 PGRI +VG+GPG+P + D V ES+ L+G+D+P V Sbjct: 6 PGRILFVGAGPGNPDLLTVRAREVLTSIADAWVDDGVGESICRLVGHDVP-VPREKIEEA 64 Query: 70 XXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVA 129 A+G + P + +IR GDP A + A+A +G DV+RLVA Sbjct: 65 EQEFARMVEEAKAKGSRRRPTPPPPPTAANIRSPEGDPQATADAMLAQAATGTDVIRLVA 124 Query: 130 GDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGDVD--- 186 G+P+ +V+AE++A+ +++PG++ S VP++AG+ +GS+ T DV G D Sbjct: 125 GNPLGNTSVLAEISAVAAHDADFQVVPGMSVPSTVPSFAGIAVGSSFTETDVTGSDDTAT 184 Query: 187 WEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLT 246 W+ LA AP PL+LQA A L LV+ L ++TP VT +GTT Q++ + TL LT Sbjct: 185 WDRLAQAPQPLVLQAEAQDLPVIESRLVDRGLPESTPATVTVNGTTRLQKTYDVTLGTLT 244 Query: 247 DPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSER 306 G L G LVVTIG V R K +WWE+RALYGW+VLVPR K QAG MS R Sbjct: 245 SCE--------GDLPGHLVVTIGVEVGARNKYSWWENRALYGWSVLVPRAKSQAGPMSTR 296 Query: 307 LTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGL 366 L +GA+P+EVPTI+VEPPRSPAQMERA+KGLVDGR+QW+VFTS NAV+AVWEK GL Sbjct: 297 LAQHGAIPLEVPTISVEPPRSPAQMERAIKGLVDGRYQWIVFTSVNAVKAVWEKLTAIGL 356 Query: 367 DARAFSGVKIACVGESTADRVRAFGISPELV-PAGEQSSLGLLDEFPPYDSIFDPVNRVL 425 DARAF+GV IA VG+ TA V GI+PEL+ PA +S+ GL+D FPPYD+ DPVNRV Sbjct: 357 DARAFAGVSIATVGKKTAKAVTDLGINPELMPPANARSASGLVDVFPPYDADIDPVNRVF 416 Query: 426 LPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTV 485 LPRADIAT+ L +GL + GW+++DV MIK+GGFDAVCFTSSSTV Sbjct: 417 LPRADIATDVLVDGLIDLGWDVDDVVAYRTVRAAPPSADIRHMIKSGGFDAVCFTSSSTV 476 Query: 486 RNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXX 545 +NLVGIAGKPH RTIIACIGP A TA E GLRVDV PE A V LVD Sbjct: 477 KNLVGIAGKPHQRTIIACIGPMAAATAKECGLRVDVVPEEAGVPELVDALAEHVAGLRAA 536 Query: 546 XXXPPPRKKSRRR 558 PPPRK +++ Sbjct: 537 GQLPPPRKVRKKK 549 >tr|A8LZJ1|A8LZJ1_SALAI Tax_Id=391037 SubName: Full=Uroporphyrinogen III synthase HEM4;[Salinispora arenicola] Length = 526 Score = 495 bits (1274), Expect = e-138 Identities = 283/536 (52%), Positives = 331/536 (61%), Gaps = 49/536 (9%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RKP GRI +VG+GPGDPG D VPES+L Sbjct: 1 MTRSRKP-VGRIAFVGAGPGDPGLLTRRGYDALVNADQVVYDRGVPESLL---------- 49 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 V A + A G +VAK L + ARSG Sbjct: 50 --------------------------DVVRAQAKQDAQLTLAEGGSGDVAKVLISAARSG 83 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 + V LVAGDP +V+ EV A+ R+ E++PG+ V TYAG+PL T ADV Sbjct: 84 LNAVHLVAGDPFGHGSVVKEVQAVARTAGHFEVVPGVGQAEGVATYAGVPLPGVRTAADV 143 Query: 182 R--GDVDWEALAAAP--GPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRS 237 +D+EALAAA GPL L A A LA L+ + DTT VT GT Q + Sbjct: 144 EDVNTLDFEALAAAVTRGPLALAADAGDLAAIRDGLLAAGVDDTTAVGVTGDGTGETQYT 203 Query: 238 VETTLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTK 297 +T+ A+ TG +V+T+G V R KL+WWE+R LYGW VLVPRTK Sbjct: 204 TTSTVDSFVAAAL--------GFTGRVVLTLGDGVGQRDKLSWWENRPLYGWKVLVPRTK 255 Query: 298 DQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 357 +QAG MS RL +YGA+P EVPTIAVEPPR+PAQMERAVKGLVDGR+ WV+FTS NAVRAV Sbjct: 256 EQAGVMSARLRAYGAIPCEVPTIAVEPPRTPAQMERAVKGLVDGRYAWVIFTSVNAVRAV 315 Query: 358 WEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSI 417 WEKF E GLDAR F GVKIAC+G++TAD VRAFGI PELVPAGEQSS GLL EF P+D + Sbjct: 316 WEKFAEHGLDARHFGGVKIACIGDATADAVRAFGIRPELVPAGEQSSEGLLAEFSPHDEV 375 Query: 418 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAV 477 DPV RVLLPRADIATETLA GL ERGWE++DV + IK+GGFDAV Sbjct: 376 LDPVGRVLLPRADIATETLAAGLTERGWEVDDVTAYRTVRAAPPPAEIRDAIKSGGFDAV 435 Query: 478 CFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD 533 FTSSSTVRNLVGIAGKPHART+++ IGPKTAETA EFGLRVDVQP A+V LV+ Sbjct: 436 LFTSSSTVRNLVGIAGKPHARTVVSVIGPKTAETATEFGLRVDVQPPHASVPDLVE 491 >tr|A4X1U3|A4X1U3_SALTO Tax_Id=369723 SubName: Full=Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; EC=2.1.1.107; EC=4.2.1.75;[Salinispora tropica] Length = 526 Score = 495 bits (1274), Expect = e-138 Identities = 283/536 (52%), Positives = 332/536 (61%), Gaps = 49/536 (9%) Query: 2 MTRGRKPRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPV 61 MTR RKP GRI +VG+GPGDPG D VPE++L Sbjct: 1 MTRTRKP-VGRIAFVGAGPGDPGLLTRRGYDALVSADQVVYDRGVPEALL---------- 49 Query: 62 SGXXXXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 V A + A G +VAK L + ARSG Sbjct: 50 --------------------------DVVRAQAKQEAQLTLAEGGSGDVAKVLISAARSG 83 Query: 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 + V LVAGDP +AV+ EV A+ R+ Q E++PG+ V TYAG+PL T ADV Sbjct: 84 LNAVHLVAGDPFGHEAVVREVQAVARTAGQFEVVPGVGQAEGVATYAGVPLPGVRTAADV 143 Query: 182 RG--DVDWEALAAAP--GPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRS 237 +D+EALAAA GPL L A LA L+ + D T VT GT Q + Sbjct: 144 EDVTTLDFEALAAAVARGPLALAVEAGDLAAIRDGLLAAGVDDATAVGVTGDGTGETQYT 203 Query: 238 VETTLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTK 297 +T+ A+ TG +V+T+G+ V R KL+WWE+R LYGW VLVPRTK Sbjct: 204 TTSTVDSFVAAAL--------GFTGRVVLTLGEGVGQRDKLSWWENRPLYGWKVLVPRTK 255 Query: 298 DQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV 357 +QAG MS RL +YGA+P EVPTIAVEPPR+PAQMERAVKGLVDGR+ WV+FTS NAVRAV Sbjct: 256 EQAGVMSARLRAYGAIPCEVPTIAVEPPRTPAQMERAVKGLVDGRYAWVIFTSVNAVRAV 315 Query: 358 WEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSI 417 WEKF E GLDAR F GVKIAC+G++TAD VRAFGI PELVPAGEQSS GLL EF P+D + Sbjct: 316 WEKFAEHGLDARHFGGVKIACIGDATADAVRAFGIRPELVPAGEQSSEGLLAEFSPHDEV 375 Query: 418 FDPVNRVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAV 477 DPV RVLLPRADIATETLA GL ERGWE++DV + IK+GGFDAV Sbjct: 376 LDPVGRVLLPRADIATETLAAGLTERGWEVDDVTAYRTVRAAPPPAEIRDAIKSGGFDAV 435 Query: 478 CFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD 533 FTSSSTVRNLVGIAGKPHART++A IGPKTAETA EFGLRVDVQP A+V LV+ Sbjct: 436 LFTSSSTVRNLVGIAGKPHARTVVAVIGPKTAETATEFGLRVDVQPPHASVPDLVE 491 >tr|C2GGC0|C2GGC0_9CORY Tax_Id=548478 SubName: Full=Uroporphyrin-III C-methyltransferase CysG;[Corynebacterium glucuronolyticum ATCC 51866] Length = 567 Score = 494 bits (1272), Expect = e-137 Identities = 270/556 (48%), Positives = 346/556 (62%), Gaps = 15/556 (2%) Query: 8 PRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLP--PVSGXX 65 P GRIT+VG+GPG+P +P V + V A+IG +LP P Sbjct: 17 PEKGRITFVGAGPGNPDLLTVTARNVLANTAYALVEPSVSDGVTAVIGAELPVPPQKKKE 76 Query: 66 XXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVV 125 G A + P + + A DP + A L ++ G DVV Sbjct: 77 AEEAYEKLCAEAKAGGARRRPPRPAPPTAAEITQMPAA--DPDKSADWLKQKSDEGIDVV 134 Query: 126 RLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGD- 184 R+V G+P+S AV+AE+N +T L I+PG++ + VP +AG+ L S +T D+ D Sbjct: 135 RVVNGNPLSNPAVLAEINTVTERGLDFHIVPGMSLPATVPMFAGITLDSNYTKVDLTRDE 194 Query: 185 -VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQ 243 V+W+ LA+AP PL+LQA A HL + L L TP VT HGTT QR+ +TTL Sbjct: 195 QVNWKGLASAPQPLVLQAEAEHLPTISEKLQAEGLPSVTPATVTVHGTTRLQRTHDTTL- 253 Query: 244 GLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEM 303 A LG D G L G LVVT+GK V +R K +WWESR LYGW VLVPR+K+QAG M Sbjct: 254 -----ANLGKLD--GDLPGELVVTLGKGVDDRTKYSWWESRPLYGWRVLVPRSKEQAGPM 306 Query: 304 SERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGE 363 S RL S+GA+P EVPTI+VEPPR+PAQM+RA+KG+V+GR++WVV TS NAV+A+W K Sbjct: 307 SARLASHGAIPQEVPTISVEPPRNPAQMDRAIKGIVEGRYEWVVLTSVNAVKALWRKVTA 366 Query: 364 FGLDARAFSGVKIACVGESTADRVRAFGISPELVP-AGEQSSLGLLDEFPPYDSIFDPVN 422 FGLDAR+F+GVK A VG TA+++ + GI+PEL+P A +Q++ GL++ FP YD DPV Sbjct: 367 FGLDARSFAGVKFAAVGAKTAEKIASLGITPELMPSARKQNAHGLVEVFPEYDEDIDPVG 426 Query: 423 RVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSS 482 RV +PRADIAT+ +AEGLR GWE++D+ +MIK+GGFDAVCFTSS Sbjct: 427 RVFMPRADIATDVVAEGLRGLGWEVDDITAYRTVRAAPPSVEIRDMIKSGGFDAVCFTSS 486 Query: 483 STVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXX 542 STV+NLVGIAGKPH+RTIIACIGP TA TA E GLRVDV PETA++ LVD Sbjct: 487 STVKNLVGIAGKPHSRTIIACIGPATAATAKEMGLRVDVVPETASIVSLVDALADHVAGL 546 Query: 543 XXXXXXPPPRKKSRRR 558 P PRKK R R Sbjct: 547 RAAGTLPAPRKKRRTR 562 >tr|C0VR96|C0VR96_9CORY Tax_Id=548477 SubName: Full=Uroporphyrin-III C-methyltransferase CysG;[Corynebacterium glucuronolyticum ATCC 51867] Length = 567 Score = 494 bits (1272), Expect = e-137 Identities = 270/556 (48%), Positives = 346/556 (62%), Gaps = 15/556 (2%) Query: 8 PRPGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLP--PVSGXX 65 P GRIT+VG+GPG+P +P V + V A+IG +LP P Sbjct: 17 PEKGRITFVGAGPGNPDLLTVTARNVLANTAYALVEPSVSDGVTAVIGAELPVPPQKKKE 76 Query: 66 XXXXXXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVV 125 G A + P + + A DP + A L ++ G DVV Sbjct: 77 AEEAYEKLCAEAKAGGARRRPPRPAPPTAAEITQMPAA--DPDKSADWLKQKSDEGIDVV 134 Query: 126 RLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGD- 184 R+V G+P+S AV+AE+N +T L I+PG++ + VP +AG+ L S +T D+ D Sbjct: 135 RVVNGNPLSNPAVLAEINTVTERGLDFHIVPGMSLPATVPMFAGITLDSNYTKVDLTRDE 194 Query: 185 -VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQ 243 V+W+ LA+AP PL+LQA A HL + L L TP VT HGTT QR+ +TTL Sbjct: 195 QVNWKGLASAPQPLVLQAEAEHLPTISEKLQAEGLPSVTPATVTVHGTTRLQRTHDTTL- 253 Query: 244 GLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEM 303 A LG D G L G LVVT+GK V +R K +WWESR LYGW VLVPR+K+QAG M Sbjct: 254 -----ANLGKLD--GDLPGELVVTLGKGVDDRTKYSWWESRPLYGWRVLVPRSKEQAGPM 306 Query: 304 SERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGE 363 S RL S+GA+P EVPTI+VEPPR+PAQM+RA+KG+V+GR++WVV TS NAV+A+W K Sbjct: 307 SARLASHGAIPQEVPTISVEPPRNPAQMDRAIKGIVEGRYEWVVLTSVNAVKALWRKVTA 366 Query: 364 FGLDARAFSGVKIACVGESTADRVRAFGISPELV-PAGEQSSLGLLDEFPPYDSIFDPVN 422 FGLDAR+F+GVK A VG TA+++ + GI+PEL+ PA +Q++ GL++ FP YD DPV Sbjct: 367 FGLDARSFAGVKFAAVGAKTAEKIASLGITPELMPPARKQNAHGLVEVFPEYDEDIDPVG 426 Query: 423 RVLLPRADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSS 482 RV +PRADIAT+ +AEGLR GWE++D+ +MIK+GGFDAVCFTSS Sbjct: 427 RVFMPRADIATDVVAEGLRGLGWEVDDITAYRTVRAAPPSVEIRDMIKSGGFDAVCFTSS 486 Query: 483 STVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXX 542 STV+NLVGIAGKPH+RTIIACIGP TA TA E GLRVDV PETA++ LVD Sbjct: 487 STVKNLVGIAGKPHSRTIIACIGPATAATAKEMGLRVDVVPETASIVSLVDALADHVAGL 546 Query: 543 XXXXXXPPPRKKSRRR 558 P PRKK R R Sbjct: 547 RAAGTLPAPRKKRRTR 562 >tr|C8RUU7|C8RUU7_CORJE Tax_Id=525262 (hemD)SubName: Full=Uroporphyrinogen-III synthase; EC=4.2.1.75;[Corynebacterium jeikeium ATCC 43734] Length = 628 Score = 494 bits (1271), Expect = e-137 Identities = 282/591 (47%), Positives = 350/591 (59%), Gaps = 45/591 (7%) Query: 11 GRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLP----PVSGXXX 66 GRI +VG+GPG+P + DP V ESV +I LP + Sbjct: 29 GRILFVGAGPGNPELLTIRARDILETTAHAWVDPSVLESVQKIIATRLPVPQEKLDAAEA 88 Query: 67 XXXXXXXXXXXXGG---------PAEGESDQAVPAVVS------SGPDIR---------- 101 G P E A PA +GP+ Sbjct: 89 EWEAKVKAAKDAGARRRPPRPAPPTAAEIVLAAPAAADPELDSETGPEAGGDTGAGAGAE 148 Query: 102 ----------PALGDPTEVAKTLTAEARSGADVVRLVAGDPMSVDAVIAEVNAITRSHLQ 151 P P +A+ + A A++G DVVRLVAG+P+S AV+ E+ + S ++ Sbjct: 149 ASTETYGEPVPEAVAPDVLAEQMVACAKAGNDVVRLVAGNPLSNPAVMNELQHVAASPVE 208 Query: 152 IEILPGLAATSAVPTYAGLPLGSAHTVADVRGDVDWEALAAAPGPLILQATASHLADAAR 211 +++PG+ + AVP + G+ LG T ADVRG DW+ LAAA PLIL A L+ A+ Sbjct: 209 FQVIPGMTGSVAVPAFTGIGLGPDVTEADVRGGTDWDQLAAAGLPLILTAAPDDLSTIAQ 268 Query: 212 TLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDPAILGGTDPA---GPLTGPLVVTI 268 L +A TP VT HGTT +QRS + TL L A G PA G L L+VT+ Sbjct: 269 ELKARGIAGATPATVTLHGTTRRQRSYDATLDTLKSIATQSG--PAAKDGELPDELIVTL 326 Query: 269 GKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSP 328 G V NR+K +WWE+RALYGWTVLVPR K+QAG MS RL S+GA+PVEVPTI+VEPPRSP Sbjct: 327 GSQVGNRSKYSWWENRALYGWTVLVPRAKNQAGPMSARLASHGAIPVEVPTISVEPPRSP 386 Query: 329 AQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVR 388 QMERA+KGLVDGR+ W+VFTS NAV+AVWEK GEFGLDARA +GV++A VG T+ V+ Sbjct: 387 VQMERAIKGLVDGRYHWIVFTSVNAVKAVWEKLGEFGLDARALAGVRVAAVGPKTSQAVK 446 Query: 389 AFGISPELVPAGE-QSSLGLLDEFPPYDSIFDPVNRVLLPRADIATETLAEGLRERGWEI 447 GI+PEL+P + +++ GL+D FPP+D D V+RVLLPRADIAT+ L +GL E GW++ Sbjct: 447 DLGITPELLPKDDARNAAGLVDVFPPHDPDLDLVDRVLLPRADIATDVLVDGLIELGWDV 506 Query: 448 EDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPK 507 EDV +MIKTGGFDAVCFTSSSTV+NLVGIAGKPHARTIIACIGP Sbjct: 507 EDVVAYRTVRAAPPSPEIRDMIKTGGFDAVCFTSSSTVKNLVGIAGKPHARTIIACIGPM 566 Query: 508 TAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXXXPPPRKKSRRR 558 A+TA E GLRVDV PE A V LVD PPPRK+ RRR Sbjct: 567 AAQTAREHGLRVDVMPEAAGVPELVDALADHVADLRAKGQLPPPRKRRRRR 617 >tr|Q8NT81|Q8NT81_CORGL Tax_Id=1718 SubName: Full=Uroporphyrinogen-III synthase; EC=2.1.1.107;[Corynebacterium glutamicum] Length = 590 Score = 493 bits (1269), Expect = e-137 Identities = 262/551 (47%), Positives = 344/551 (62%), Gaps = 10/551 (1%) Query: 10 PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXX 69 PG++ +VG+GPG+P TD V V A + ++P Sbjct: 45 PGKVIFVGAGPGNPDLLTVRAREVLGNAVRAITDEQVLSGVRAFVATEIPVPEDKLQAAE 104 Query: 70 XXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVA 129 PA ++ + P ++ + + G DV+RLV Sbjct: 105 DEYERICIEAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQDALSYGGDVIRLVT 164 Query: 130 GDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG-DVDWE 188 G+P+S DA +AE++A++ + L+ +++PG++ + VP +AG+ LGS +T DV G ++DW+ Sbjct: 165 GNPLSSDATLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNLDWD 224 Query: 189 ALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDP 248 LA+AP PL+LQA L+ A+ L ++ TP VTA+GTT QR+ +TTL Sbjct: 225 QLASAPQPLVLQARVDDLSRIAQELKARNMSLETPVSVTANGTTRLQRTYDTTL------ 278 Query: 249 AILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLT 308 +L D L+GPLVVT+GK V +R+K +WWE+RALYGW VLVPR ++QA MS RL+ Sbjct: 279 GLLHKLD--AELSGPLVVTLGKGVDDRSKYSWWENRALYGWRVLVPRAREQAASMSARLS 336 Query: 309 SYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDA 368 S+GA+P EVPTI+VEPPR+PAQMERA+KG+V+GR+QWVV TS NAV+AVWEK EFGLD+ Sbjct: 337 SHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDS 396 Query: 369 RAFSGVKIACVGESTADRVRAFGISPELVPA-GEQSSLGLLDEFPPYDSIFDPVNRVLLP 427 R+F+GV+IA VGE TA +RA GI+PEL+PA Q++ GL+D FP Y DPV RVLLP Sbjct: 397 RSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLP 456 Query: 428 RADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRN 487 RADIAT+ L +GL GWE+EDV +MIKTGGFDAV FTSSSTV+N Sbjct: 457 RADIATDVLVDGLTHLGWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKN 516 Query: 488 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXX 547 LVGIAGKPH RTI+ACIGP TA TA E GLRVDV PE A V L+D Sbjct: 517 LVGIAGKPHPRTIVACIGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGE 576 Query: 548 XPPPRKKSRRR 558 PPPRKK RRR Sbjct: 577 LPPPRKKRRRR 587 >tr|Q6M7T9|Q6M7T9_CORGL Tax_Id=1718 (hemD)SubName: Full=UROPORPHYRINOGEN III SYNTHASE/METHYLTRANSFERASE; EC=4.2.1.75;[Corynebacterium glutamicum] Length = 598 Score = 493 bits (1269), Expect = e-137 Identities = 262/551 (47%), Positives = 344/551 (62%), Gaps = 10/551 (1%) Query: 10 PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXX 69 PG++ +VG+GPG+P TD V V A + ++P Sbjct: 53 PGKVIFVGAGPGNPDLLTVRAREVLGNAVRAITDEQVLSGVRAFVATEIPVPEDKLQAAE 112 Query: 70 XXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVA 129 PA ++ + P ++ + + G DV+RLV Sbjct: 113 DEYERICIEAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQDALSYGGDVIRLVT 172 Query: 130 GDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG-DVDWE 188 G+P+S DA +AE++A++ + L+ +++PG++ + VP +AG+ LGS +T DV G ++DW+ Sbjct: 173 GNPLSSDATLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNLDWD 232 Query: 189 ALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDP 248 LA+AP PL+LQA L+ A+ L ++ TP VTA+GTT QR+ +TTL Sbjct: 233 QLASAPQPLVLQARVDDLSRIAQELKARNMSLETPVSVTANGTTRLQRTYDTTL------ 286 Query: 249 AILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLT 308 +L D L+GPLVVT+GK V +R+K +WWE+RALYGW VLVPR ++QA MS RL+ Sbjct: 287 GLLHKLD--AELSGPLVVTLGKGVDDRSKYSWWENRALYGWRVLVPRAREQAASMSARLS 344 Query: 309 SYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDA 368 S+GA+P EVPTI+VEPPR+PAQMERA+KG+V+GR+QWVV TS NAV+AVWEK EFGLD+ Sbjct: 345 SHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDS 404 Query: 369 RAFSGVKIACVGESTADRVRAFGISPELVPA-GEQSSLGLLDEFPPYDSIFDPVNRVLLP 427 R+F+GV+IA VGE TA +RA GI+PEL+PA Q++ GL+D FP Y DPV RVLLP Sbjct: 405 RSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLP 464 Query: 428 RADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRN 487 RADIAT+ L +GL GWE+EDV +MIKTGGFDAV FTSSSTV+N Sbjct: 465 RADIATDVLVDGLTHLGWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKN 524 Query: 488 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXX 547 LVGIAGKPH RTI+ACIGP TA TA E GLRVDV PE A V L+D Sbjct: 525 LVGIAGKPHPRTIVACIGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGE 584 Query: 548 XPPPRKKSRRR 558 PPPRKK RRR Sbjct: 585 LPPPRKKRRRR 595 >tr|A4QB70|A4QB70_CORGB Tax_Id=340322 SubName: Full=Putative uncharacterized protein;[Corynebacterium glutamicum] Length = 598 Score = 491 bits (1265), Expect = e-137 Identities = 262/551 (47%), Positives = 341/551 (61%), Gaps = 10/551 (1%) Query: 10 PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXX 69 PG++ +VG+GPG+P TD V V A + ++P Sbjct: 53 PGKVIFVGAGPGNPDLLTVRAREVLGNAVRAITDEQVLSGVRAFVATEIPVPEDKLQAAE 112 Query: 70 XXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVA 129 PA ++ + P ++ + + G DV+RLV Sbjct: 113 DEYERICIEAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQNALSYGGDVIRLVT 172 Query: 130 GDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG-DVDWE 188 G+P+S D +AE++A++ + L+ +++PG++ + VP +AG+ LGS +T DV G +VDW+ Sbjct: 173 GNPLSSDTTLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNVDWD 232 Query: 189 ALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDP 248 LA+AP PL+LQA L+ A+ L + TP VTA+GTT QR+ +TTL Sbjct: 233 QLASAPQPLVLQARVQDLSRIAQELKARNMPLETPVSVTANGTTRLQRTYDTTL------ 286 Query: 249 AILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLT 308 +L D L GPLVVT+GK V +R+K +WWE+RALYGW VLVPR ++QA MS RL+ Sbjct: 287 GLLHKLD--AELNGPLVVTLGKGVDDRSKYSWWENRALYGWRVLVPRAREQAASMSARLS 344 Query: 309 SYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDA 368 S+GA+P EVPTI+VEPPR+PAQMERA+KG+V+GR+QWVV TS NAV+AVWEK EFGLD+ Sbjct: 345 SHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDS 404 Query: 369 RAFSGVKIACVGESTADRVRAFGISPELVPA-GEQSSLGLLDEFPPYDSIFDPVNRVLLP 427 R+F+GV+IA VGE TA +RA GI+PEL+PA Q++ GL+D FP Y DPV RVLLP Sbjct: 405 RSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLP 464 Query: 428 RADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRN 487 RADIAT+ L +GL GWE+EDV +MIKTGGFDAV FTSSSTV+N Sbjct: 465 RADIATDVLVDGLTHLGWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKN 524 Query: 488 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXX 547 LVGIAGKPH RTI+ACIGP TA TA E GLRVDV PE A V L+D Sbjct: 525 LVGIAGKPHPRTIVACIGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGE 584 Query: 548 XPPPRKKSRRR 558 PPPRKK RRR Sbjct: 585 LPPPRKKRRRR 595 >tr|Q8GMZ0|Q8GMZ0_CORGL Tax_Id=1718 (hemD)SubName: Full=Uroporphobilinogen-III synthase;[Corynebacterium glutamicum] Length = 590 Score = 491 bits (1265), Expect = e-137 Identities = 262/551 (47%), Positives = 341/551 (61%), Gaps = 10/551 (1%) Query: 10 PGRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLPPVSGXXXXXX 69 PG++ +VG+GPG+P TD V V A + ++P Sbjct: 45 PGKVIFVGAGPGNPDLLTVRAREVLGNAVRAITDEQVLSGVRAFVATEIPVPEDKLQAAE 104 Query: 70 XXXXXXXXXGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVA 129 PA ++ + P ++ + + G DV+RLV Sbjct: 105 DEYERICIEAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQNALSYGGDVIRLVT 164 Query: 130 GDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRG-DVDWE 188 G+P+S D +AE++A++ + L+ +++PG++ + VP +AG+ LGS +T DV G +VDW+ Sbjct: 165 GNPLSSDTTLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNVDWD 224 Query: 189 ALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDP 248 LA+AP PL+LQA L+ A+ L + TP VTA+GTT QR+ +TTL Sbjct: 225 QLASAPQPLVLQARVQDLSRIAQELKARNMPLETPVSVTANGTTRLQRTYDTTL------ 278 Query: 249 AILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLT 308 +L D L GPLVVT+GK V +R+K +WWE+RALYGW VLVPR ++QA MS RL+ Sbjct: 279 GLLHKLD--AELNGPLVVTLGKGVDDRSKYSWWENRALYGWRVLVPRAREQAASMSARLS 336 Query: 309 SYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDA 368 S+GA+P EVPTI+VEPPR+PAQMERA+KG+V+GR+QWVV TS NAV+AVWEK EFGLD+ Sbjct: 337 SHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDS 396 Query: 369 RAFSGVKIACVGESTADRVRAFGISPELVPA-GEQSSLGLLDEFPPYDSIFDPVNRVLLP 427 R+F+GV+IA VGE TA +RA GI+PEL+PA Q++ GL+D FP Y DPV RVLLP Sbjct: 397 RSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLP 456 Query: 428 RADIATETLAEGLRERGWEIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRN 487 RADIAT+ L +GL GWE+EDV +MIKTGGFDAV FTSSSTV+N Sbjct: 457 RADIATDVLVDGLTHLGWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKN 516 Query: 488 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXX 547 LVGIAGKPH RTI+ACIGP TA TA E GLRVDV PE A V L+D Sbjct: 517 LVGIAGKPHPRTIVACIGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGE 576 Query: 548 XPPPRKKSRRR 558 PPPRKK RRR Sbjct: 577 LPPPRKKRRRR 587 >tr|Q4JSX6|Q4JSX6_CORJK Tax_Id=306537 (hemD)SubName: Full=Uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase; EC=4.2.1.75;[Corynebacterium jeikeium] Length = 628 Score = 488 bits (1257), Expect = e-136 Identities = 279/593 (47%), Positives = 350/593 (59%), Gaps = 49/593 (8%) Query: 11 GRITYVGSGPGDPGXXXXXXXXXXXXXXXXFTDPDVPESVLALIGNDLP----PVSGXXX 66 GRI +VG+GPG+P + DP V ESV +I LP + Sbjct: 29 GRILFVGAGPGNPELLTIRARDILETTAHAWVDPSVLESVQKIIATRLPVPQEKLDAAEA 88 Query: 67 XXXXXXXXXXXXGG---------PAEGESDQAVPAVVSSGPDIRPALGD----------- 106 G P E A PA ++ P++ LG Sbjct: 89 EWEAKVKAAKDAGARRRPPRPTPPTAAEIVLAAPA--ATDPELAAELGPEAGGETGAEAG 146 Query: 107 -----------------PTEVAKTLTAEARSGADVVRLVAGDPMSVDAVIAEVNAITRSH 149 P +A+ + A A +G DVVRLVAG+P+S AV+ E+ + S Sbjct: 147 AETGKETYGEPVPEAVAPEVLAEQMVACAMAGNDVVRLVAGNPLSNPAVMNELQHVAASS 206 Query: 150 LQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGDVDWEALAAAPGPLILQATASHLADA 209 ++ +++PG+ + AVP + G+ LG T ADVRG DW+ LAAA PLIL A +LA Sbjct: 207 VEFQVIPGMTGSVAVPAFTGIGLGPDVTEADVRGGADWDQLAAAGLPLILTAAPDNLATI 266 Query: 210 ARTLVEHELADTTPCVVTAHGTTCQQRSVETTLQGLTDPAILGGTDPA---GPLTGPLVV 266 A+ L ++ TP VT HGTT +QRS + TL L G PA G L L+V Sbjct: 267 AQELKARGISGATPATVTLHGTTRRQRSYDATLDTLKSITTQSG--PAAKDGELPAELIV 324 Query: 267 TIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPR 326 T+G V NR+K +WWE+RALYGWTVLVPR K+QAG MS RL S+GA+PVEVPTI+VEPPR Sbjct: 325 TLGSQVGNRSKYSWWENRALYGWTVLVPRAKNQAGPMSTRLASHGAIPVEVPTISVEPPR 384 Query: 327 SPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADR 386 SP QMERA+KGLVDGR+ W+VFTS NAV+AVWEK EFGLDARA +GV++A VG T+ Sbjct: 385 SPVQMERAIKGLVDGRYHWIVFTSVNAVKAVWEKLREFGLDARALAGVRVAAVGPKTSQA 444 Query: 387 VRAFGISPELVPAGE-QSSLGLLDEFPPYDSIFDPVNRVLLPRADIATETLAEGLRERGW 445 V+ GI+PEL+P + +++ GL++ FPP+D D V+RVLLPRADIAT+ L +GL E GW Sbjct: 445 VKDLGITPELLPKDDARNAAGLVEVFPPHDPDLDLVDRVLLPRADIATDVLVDGLIELGW 504 Query: 446 EIEDVXXXXXXXXXXXXXXXXEMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIG 505 ++EDV +MIKTGGFDAVCFTSSSTV+NLVGIAGKPHARTIIACIG Sbjct: 505 DVEDVVAYRTVRAAPPSPEIRDMIKTGGFDAVCFTSSSTVKNLVGIAGKPHARTIIACIG 564 Query: 506 PKTAETAAEFGLRVDVQPETAAVGPLVDXXXXXXXXXXXXXXXPPPRKKSRRR 558 P A+TA E GLRVDV PE A V LVD PPPRK+ RRR Sbjct: 565 PMAAQTAREHGLRVDVMPEAAGVPELVDALADHVADLRAKGQLPPPRKRRRRR 617 Database: Amellifera_nr Posted date: Feb 5, 2010 5:10 AM Number of letters in database: 3,846,993,858 Number of sequences in database: 11,275,203 Lambda K H 0.315 0.134 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11275203 Number of Hits to DB: 3,883,163,178 Number of extensions: 156151149 Number of successful extensions: 414878 Number of sequences better than 10.0: 2946 Number of HSP's gapped: 413519 Number of HSP's successfully gapped: 3006 Length of query: 558 Length of database: 3,846,993,858 Length adjustment: 143 Effective length of query: 415 Effective length of database: 2,234,639,829 Effective search space: 927375529035 Effective search space used: 927375529035 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 83 (36.6 bits)