BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MMAR_1726 (473 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,275,203 sequences; 3,846,993,858 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|B2HII1|LEUC_MYCMM Tax_Id=216594 (leuC)RecName: Full=3-isoprop... 927 0.0 sp|A0PPZ6|LEUC_MYCUA Tax_Id=362242 (leuC)RecName: Full=3-isoprop... 919 0.0 sp|Q73VI7|LEUC_MYCPA Tax_Id=1770 (leuC)RecName: Full=3-isopropyl... 854 0.0 sp|A0QJB7|LEUC_MYCA1 Tax_Id=243243 (leuC)RecName: Full=3-isoprop... 854 0.0 sp|O53237|LEUC_MYCTU Tax_Id=1773 (leuC)RecName: Full=3-isopropyl... 846 0.0 sp|A5U6Z9|LEUC_MYCTA Tax_Id=419947 (leuC)RecName: Full=3-isoprop... 846 0.0 tr|C6DW61|C6DW61_MYCTK Tax_Id=478434 SubName: Full=3-isopropylma... 846 0.0 tr|A5WRP1|A5WRP1_MYCTF Tax_Id=336982 SubName: Full=3-isopropylma... 846 0.0 tr|A4KKP4|A4KKP4_MYCTU Tax_Id=395095 SubName: Full=3-isopropylma... 846 0.0 tr|A2VLV9|A2VLV9_MYCTU Tax_Id=348776 SubName: Full=3-isopropylma... 846 0.0 sp|C1AGA3|LEUC_MYCBT Tax_Id=561275 (leuC)RecName: Full=3-isoprop... 845 0.0 sp|A1KMY2|LEUC_MYCBP Tax_Id=410289 (leuC)RecName: Full=3-isoprop... 845 0.0 sp|Q7TXH6|LEUC_MYCBO Tax_Id=1765 (leuC)RecName: Full=3-isopropyl... 845 0.0 sp|O33123|LEUC_MYCLE Tax_Id=1769 (leuC)RecName: Full=3-isopropyl... 822 0.0 tr|B8ZS12|B8ZS12_MYCLB Tax_Id=561304 (leuC)SubName: Full=3-isopr... 822 0.0 sp|A1T700|LEUC_MYCVP Tax_Id=350058 (leuC)RecName: Full=3-isoprop... 814 0.0 sp|A3PXR2|LEUC_MYCSJ Tax_Id=164757 (leuC)RecName: Full=3-isoprop... 814 0.0 sp|Q1BAQ4|LEUC_MYCSS Tax_Id=164756 (leuC)RecName: Full=3-isoprop... 813 0.0 sp|A1UEA8|LEUC_MYCSK Tax_Id=189918 (leuC)RecName: Full=3-isoprop... 813 0.0 sp|A4TE23|LEUC_MYCGI Tax_Id=350054 (leuC)RecName: Full=3-isoprop... 811 0.0 tr|A0QUY9|A0QUY9_MYCS2 Tax_Id=246196 (leuC)SubName: Full=3-isopr... 803 0.0 tr|C1B2N0|C1B2N0_RHOOB Tax_Id=632772 (leuC)SubName: Full=3-isopr... 781 0.0 sp|Q5YRY0|LEUC_NOCFA Tax_Id=37329 (leuC)RecName: Full=3-isopropy... 780 0.0 tr|C0ZXN1|C0ZXN1_RHOE4 Tax_Id=234621 (leuC)SubName: Full=3-isopr... 780 0.0 sp|B1MDQ1|LEUC_MYCA9 Tax_Id=561007 (leuC)RecName: Full=3-isoprop... 775 0.0 tr|Q0S2G4|Q0S2G4_RHOSR Tax_Id=101510 (leuC2)SubName: Full=3-isop... 775 0.0 tr|C3JSK4|C3JSK4_RHOER Tax_Id=596309 (leuC)SubName: Full=3-isopr... 774 0.0 tr|D0LC33|D0LC33_GORB4 Tax_Id=526226 SubName: Full=3-isopropylma... 771 0.0 tr|C7MXF5|C7MXF5_SACVD Tax_Id=471857 SubName: Full=3-isopropylma... 766 0.0 tr|C6WG49|C6WG49_ACTMD Tax_Id=446462 SubName: Full=3-isopropylma... 754 0.0 tr|C2AUC8|C2AUC8_TSUPA Tax_Id=521096 SubName: Full=3-isopropylma... 743 0.0 sp|A4FMP2|LEUC_SACEN Tax_Id=405948 (leuC)RecName: Full=3-isoprop... 735 0.0 sp|Q47SA3|LEUC_THEFY Tax_Id=269800 (leuC)RecName: Full=3-isoprop... 731 0.0 tr|C1YHU3|C1YHU3_NOCDA Tax_Id=446468 SubName: Full=3-isopropylma... 726 0.0 tr|B0REY2|B0REY2_CLAMS Tax_Id=31964 (leuC)SubName: Full=3-isopro... 726 0.0 sp|A0LVA3|LEUC_ACIC1 Tax_Id=351607 (leuC)RecName: Full=3-isoprop... 725 0.0 tr|C0W2R0|C0W2R0_9ACTO Tax_Id=525246 (leuC)SubName: Full=3-isopr... 724 0.0 tr|A5CQN2|A5CQN2_CLAM3 Tax_Id=443906 (leuC)SubName: Full=LeuC pr... 722 0.0 sp|A6W7Q7|LEUC_KINRD Tax_Id=266940 (leuC)RecName: Full=3-isoprop... 721 0.0 tr|D1BDJ2|D1BDJ2_9MICO Tax_Id=446469 SubName: Full=3-isopropylma... 714 0.0 sp|B8HAC9|LEUC_ARTCA Tax_Id=452863 (leuC)RecName: Full=3-isoprop... 711 0.0 sp|O86534|LEUC_STRCO Tax_Id=1902 (leuC)RecName: Full=3-isopropyl... 710 0.0 tr|C5CAC8|C5CAC8_MICLC Tax_Id=465515 SubName: Full=3-isopropylma... 710 0.0 tr|D1AB58|D1AB58_THECU Tax_Id=471852 SubName: Full=3-isopropylma... 710 0.0 tr|C8XEL9|C8XEL9_NAKMY Tax_Id=479431 SubName: Full=3-isopropylma... 709 0.0 tr|C1RN67|C1RN67_9CELL Tax_Id=446466 SubName: Full=3-isopropylma... 709 0.0 sp|B1VZ03|LEUC_STRGG Tax_Id=455632 (leuC)RecName: Full=3-isoprop... 709 0.0 tr|C9N9V0|C9N9V0_9ACTO Tax_Id=591167 SubName: Full=3-isopropylma... 709 0.0 tr|B5H064|B5H064_STRCL Tax_Id=443255 SubName: Full=3-isopropylma... 709 0.0 tr|A7DWG1|A7DWG1_STRCL Tax_Id=1901 (leuC)SubName: Full=Putative ... 709 0.0 >sp|B2HII1|LEUC_MYCMM Tax_Id=216594 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium marinum] Length = 473 Score = 927 bits (2396), Expect = 0.0 Identities = 461/473 (97%), Positives = 461/473 (97%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR Sbjct: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP Sbjct: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LPAGVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPAGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN Sbjct: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN Sbjct: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 >sp|A0PPZ6|LEUC_MYCUA Tax_Id=362242 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium ulcerans] Length = 473 Score = 919 bits (2374), Expect = 0.0 Identities = 457/473 (96%), Positives = 459/473 (97%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLH VHEVTSPQAFDGLRLAGRPVRR Sbjct: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHQVHEVTSPQAFDGLRLAGRPVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP Sbjct: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPL PFKTMAVNVDG+ Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLWPFKTMAVNVDGQ 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LPAGVS GTGGGQGHVIEY+GSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPAGVSAKDIILALIAKIGTGGGQGHVIEYQGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN Sbjct: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN Sbjct: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 >sp|Q73VI7|LEUC_MYCPA Tax_Id=1770 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium paratuberculosis] Length = 476 Score = 854 bits (2207), Expect = 0.0 Identities = 420/469 (89%), Positives = 436/469 (92%) Query: 5 TREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 64 T RTLAEKVWDDHVVVSG PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT Sbjct: 8 TATPRTLAEKVWDDHVVVSGGANEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 67 Query: 65 IATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGL 124 +ATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFG+RL+PMGD EQGIVHVVGPQLGL Sbjct: 68 LATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHVVGPQLGL 127 Query: 125 TQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAG 184 TQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG LPAG Sbjct: 128 TQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPAG 187 Query: 185 VSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDE 244 V+ GTGGGQGHVIEYRGSAIESLSMEGRMT+CNMSIEAGARAGM+APD+ Sbjct: 188 VTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGMIAPDD 247 Query: 245 TTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQG 304 TTYE+LR+RPHAP GAQWDAA+ YWQQLRTDPGAVFDTEV+LDAA LSPFVTWGTNPGQG Sbjct: 248 TTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEVYLDAASLSPFVTWGTNPGQG 307 Query: 305 VPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRV 364 VPL A VPDPEL+ DD ERQAAEKALAYMDL PG MRDIAVDAVFVGSCTNGRIEDLRV Sbjct: 308 VPLAAAVPDPELMTDDAERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRV 367 Query: 365 VAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQ 424 VA+VLRGRKVAPGVRML+VPGSMRVRAQAE EGLGEVFT AGAEWRQAGCSMCLGMNPDQ Sbjct: 368 VADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCLGMNPDQ 427 Query: 425 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL+ Sbjct: 428 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLD 476 >sp|A0QJB7|LEUC_MYCA1 Tax_Id=243243 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium avium] Length = 476 Score = 854 bits (2206), Expect = 0.0 Identities = 419/469 (89%), Positives = 436/469 (92%) Query: 5 TREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 64 T RTLAEKVWDDHVVVSG PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT Sbjct: 8 TATPRTLAEKVWDDHVVVSGGANEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 67 Query: 65 IATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGL 124 +ATEDHNVPT+DIDKPIADPVSRTQVETLRRNCAEFG+RL+PMGD EQGIVHVVGPQLGL Sbjct: 68 LATEDHNVPTIDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHVVGPQLGL 127 Query: 125 TQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAG 184 TQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG LPAG Sbjct: 128 TQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPAG 187 Query: 185 VSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDE 244 V+ GTGGGQGHVIEYRGSAIESLSMEGRMT+CNMSIEAGARAGM+APD+ Sbjct: 188 VTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGMIAPDD 247 Query: 245 TTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQG 304 TTYE+LR+RPHAP GAQWDAA+ YWQQLRTDPGAVFDTEV+LDAA LSPFVTWGTNPGQG Sbjct: 248 TTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEVYLDAASLSPFVTWGTNPGQG 307 Query: 305 VPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRV 364 VPL A VPDPEL+ DD ERQAAEKALAYMDL PG MRDIAVDAVFVGSCTNGRIEDLRV Sbjct: 308 VPLAAAVPDPELMTDDAERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRV 367 Query: 365 VAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQ 424 VA+VLRGRKVAPGVRML+VPGSMRVRAQAE EGLGEVFT AGAEWRQAGCSMCLGMNPDQ Sbjct: 368 VADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCLGMNPDQ 427 Query: 425 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL+ Sbjct: 428 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLD 476 >sp|O53237|LEUC_MYCTU Tax_Id=1773 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium tuberculosis] Length = 473 Score = 846 bits (2186), Expect = 0.0 Identities = 422/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|A5U6Z9|LEUC_MYCTA Tax_Id=419947 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium tuberculosis] Length = 473 Score = 846 bits (2186), Expect = 0.0 Identities = 422/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|C6DW61|C6DW61_MYCTK Tax_Id=478434 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis] Length = 473 Score = 846 bits (2186), Expect = 0.0 Identities = 422/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|A5WRP1|A5WRP1_MYCTF Tax_Id=336982 SubName: Full=3-isopropylmalate dehydratase large subunit leuC;[Mycobacterium tuberculosis] Length = 473 Score = 846 bits (2186), Expect = 0.0 Identities = 422/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|A4KKP4|A4KKP4_MYCTU Tax_Id=395095 SubName: Full=3-isopropylmalate dehydratase (Large subunit) leuC;[Mycobacterium tuberculosis str. Haarlem] Length = 473 Score = 846 bits (2186), Expect = 0.0 Identities = 422/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >tr|A2VLV9|A2VLV9_MYCTU Tax_Id=348776 SubName: Full=3-isopropylmalate dehydratase (Large subunit) leuC;[Mycobacterium tuberculosis C] Length = 473 Score = 846 bits (2186), Expect = 0.0 Identities = 422/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMRDIAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|C1AGA3|LEUC_MYCBT Tax_Id=561275 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 845 bits (2182), Expect = 0.0 Identities = 421/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMR+IAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|A1KMY2|LEUC_MYCBP Tax_Id=410289 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 845 bits (2182), Expect = 0.0 Identities = 421/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMR+IAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|Q7TXH6|LEUC_MYCBO Tax_Id=1765 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium bovis] Length = 473 Score = 845 bits (2182), Expect = 0.0 Identities = 421/473 (89%), Positives = 436/473 (92%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 MALQT E RTLAEK+WDDH+VVSG APDLIYIDLHLVHEVTSPQAFDGLRLAGR VRR Sbjct: 1 MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 P+LT+ATEDHNVPTVDID+PIADPVSRTQVETLRRNCAEFGIRLH MGD+EQGIVHVVGP Sbjct: 61 PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR Sbjct: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDETTY +LR RPHAPTGAQWD AL YWQ+LRTD GAVFDTEV+LDAA LSPFVTWGTN Sbjct: 241 APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGVPL A VPDP+L+ DD ERQAAEKALAYMDL PG AMR+IAVDAVFVGSCTNGRIE Sbjct: 301 PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLRVVAEVLRGRKVA GVRMLIVPGSMRVRAQAE EGLGE+FT AGA+WRQAGCSMCLGM Sbjct: 361 DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 NPDQLA GERCAATSNRNFEGRQG GGRTHLVSPAVAAATAVRGTLS+PADLN Sbjct: 421 NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN 473 >sp|O33123|LEUC_MYCLE Tax_Id=1769 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium leprae] Length = 476 Score = 822 bits (2124), Expect = 0.0 Identities = 406/472 (86%), Positives = 429/472 (90%), Gaps = 4/472 (0%) Query: 6 REARTLAEKVWDDHVVVSGR----NEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRP 61 R+ RTLAEKVWDDHVVV+G+ + PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP Sbjct: 5 RKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRP 64 Query: 62 DLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQ 121 DLT+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD+EQGIVHVVGPQ Sbjct: 65 DLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 124 Query: 122 LGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRL 181 LGLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRL Sbjct: 125 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 184 Query: 182 PAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVA 241 PAGV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVA Sbjct: 185 PAGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 244 Query: 242 PDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNP 301 PDETTYE+LR+RPHAPTG QWDAA+ YWQQLRTD AVFDTEV+LDA LSPFVTWGTNP Sbjct: 245 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 304 Query: 302 GQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIED 361 GQGVPL A+VPDPEL+ DD RQAAEKALAYMDL PG MRDIAVDAVFVGSCTNGRIED Sbjct: 305 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 364 Query: 362 LRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMN 421 LR+VA+VLRG KVA GVRMLIVPGSMRVRAQAE EGLGE+F AGA+WRQ GCSMCLGMN Sbjct: 365 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 424 Query: 422 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT SAPADLN Sbjct: 425 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 476 >tr|B8ZS12|B8ZS12_MYCLB Tax_Id=561304 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit;[Mycobacterium leprae] Length = 485 Score = 822 bits (2124), Expect = 0.0 Identities = 406/472 (86%), Positives = 429/472 (90%), Gaps = 4/472 (0%) Query: 6 REARTLAEKVWDDHVVVSGR----NEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRP 61 R+ RTLAEKVWDDHVVV+G+ + PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP Sbjct: 14 RKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRP 73 Query: 62 DLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQ 121 DLT+ATEDHNVPTVDIDKPIADPVSR QVETLRRNCAEFG+RLHPMGD+EQGIVHVVGPQ Sbjct: 74 DLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQ 133 Query: 122 LGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRL 181 LGLTQPGMTIVCGDSHTSTHGAFGA+AMGIGTSE+EHVLATQTLPLRPFKTMAV VDGRL Sbjct: 134 LGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRL 193 Query: 182 PAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVA 241 PAGV+ GTGGGQG+V+EYRGS IES+SMEGRMTICNMSIEAGARAGMVA Sbjct: 194 PAGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVA 253 Query: 242 PDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNP 301 PDETTYE+LR+RPHAPTG QWDAA+ YWQQLRTD AVFDTEV+LDA LSPFVTWGTNP Sbjct: 254 PDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNP 313 Query: 302 GQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIED 361 GQGVPL A+VPDPEL+ DD RQAAEKALAYMDL PG MRDIAVDAVFVGSCTNGRIED Sbjct: 314 GQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIED 373 Query: 362 LRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMN 421 LR+VA+VLRG KVA GVRMLIVPGSMRVRAQAE EGLGE+F AGA+WRQ GCSMCLGMN Sbjct: 374 LRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMN 433 Query: 422 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGT SAPADLN Sbjct: 434 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN 485 >sp|A1T700|LEUC_MYCVP Tax_Id=350058 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium vanbaalenii] Length = 481 Score = 814 bits (2103), Expect = 0.0 Identities = 399/470 (84%), Positives = 425/470 (90%), Gaps = 4/470 (0%) Query: 7 EARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 62 + RTLAEKVW DHVVV+G E PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD Sbjct: 6 QPRTLAEKVWSDHVVVAGTGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 65 Query: 63 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQL 122 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVH++GPQL Sbjct: 66 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHIIGPQL 125 Query: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 GLTQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG+LP Sbjct: 126 GLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGQLP 185 Query: 183 AGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 GVS GTGGGQGHVIEYRGSAIESLSMEGRMT+CNMSIEAGARAGM+AP Sbjct: 186 PGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGMIAP 245 Query: 243 DETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPG 302 DETT+E+LR RPHAP GA+WDAA+ W+QLRTD GA FDTE+++DA+ LSPFVTWGTNPG Sbjct: 246 DETTFEFLRGRPHAPKGAEWDAAVAVWRQLRTDEGAQFDTEIYIDASTLSPFVTWGTNPG 305 Query: 303 QGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDL 362 QGVPL VPDPEL+ D+ ERQAAEKALAYMDL G MR I VD VFVGSCTNGRIEDL Sbjct: 306 QGVPLSDPVPDPELMFDEAERQAAEKALAYMDLRAGTPMRQIPVDTVFVGSCTNGRIEDL 365 Query: 363 RVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNP 422 RVVA++LRGR+VA VRML+VPGSMRVRAQAE EGLGE+FT AGAEWRQAGCSMCLGMNP Sbjct: 366 RVVADILRGRRVADNVRMLVVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNP 425 Query: 423 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 DQLAPGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLS+PADL Sbjct: 426 DQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADL 475 >sp|A3PXR2|LEUC_MYCSJ Tax_Id=164757 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 814 bits (2103), Expect = 0.0 Identities = 401/474 (84%), Positives = 424/474 (89%), Gaps = 4/474 (0%) Query: 4 QTREARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 59 Q RT+AEKVW DHVV G E PDLIYIDLHLVHEVTSPQAFDGLRLA RPVR Sbjct: 3 QPATPRTMAEKVWADHVVAHGTGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVR 62 Query: 60 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVG 119 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGD EQGIVH++G Sbjct: 63 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIG 122 Query: 120 PQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG 179 PQLGLTQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPF+TMAVNVDG Sbjct: 123 PQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDG 182 Query: 180 RLPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM 239 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM Sbjct: 183 ELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM 242 Query: 240 VAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGT 299 VAPD+TT+E+LR RPHAPTGA WDAA+ W+QLRTDPGA FDTEVHLDAAELSPFVTWGT Sbjct: 243 VAPDDTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGT 302 Query: 300 NPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRI 359 NPGQGVPL VPDPELI D+GERQAAEKAL YM L+ G AMRD+AVD VFVGSCTNGRI Sbjct: 303 NPGQGVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRI 362 Query: 360 EDLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLG 419 EDLRVVA+VLRGR+VA G+RML+VPGSMRVRAQAE EGL +F AGAEWRQAGCSMCLG Sbjct: 363 EDLRVVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLG 422 Query: 420 MNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 MNPDQL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLS+PADL+ Sbjct: 423 MNPDQLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLS 476 >sp|Q1BAQ4|LEUC_MYCSS Tax_Id=164756 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 813 bits (2101), Expect = 0.0 Identities = 401/474 (84%), Positives = 424/474 (89%), Gaps = 4/474 (0%) Query: 4 QTREARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 59 Q RT+AEKVW DHVV G E PDLIYIDLHLVHEVTSPQAFDGLRLA RPVR Sbjct: 3 QPATPRTMAEKVWADHVVAHGIGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVR 62 Query: 60 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVG 119 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGD EQGIVH++G Sbjct: 63 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIG 122 Query: 120 PQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG 179 PQLGLTQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPF+TMAVNVDG Sbjct: 123 PQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDG 182 Query: 180 RLPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM 239 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM Sbjct: 183 ELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM 242 Query: 240 VAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGT 299 VAPD+TT+E+LR RPHAPTGA WDAA+ W+QLRTDPGA FDTEVHLDAAELSPFVTWGT Sbjct: 243 VAPDDTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGT 302 Query: 300 NPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRI 359 NPGQGVPL VPDPELI D+GERQAAEKAL YM L+ G AMRD+AVD VFVGSCTNGRI Sbjct: 303 NPGQGVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRI 362 Query: 360 EDLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLG 419 EDLRVVA+VLRGR+VA G+RML+VPGSMRVRAQAE EGL +F AGAEWRQAGCSMCLG Sbjct: 363 EDLRVVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLG 422 Query: 420 MNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 MNPDQL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLS+PADL+ Sbjct: 423 MNPDQLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLS 476 >sp|A1UEA8|LEUC_MYCSK Tax_Id=189918 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium sp.] Length = 481 Score = 813 bits (2101), Expect = 0.0 Identities = 401/474 (84%), Positives = 424/474 (89%), Gaps = 4/474 (0%) Query: 4 QTREARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVR 59 Q RT+AEKVW DHVV G E PDLIYIDLHLVHEVTSPQAFDGLRLA RPVR Sbjct: 3 QPATPRTMAEKVWADHVVAHGIGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLANRPVR 62 Query: 60 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVG 119 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGD EQGIVH++G Sbjct: 63 RPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDAEQGIVHIIG 122 Query: 120 PQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG 179 PQLGLTQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPF+TMAVNVDG Sbjct: 123 PQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAVNVDG 182 Query: 180 RLPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM 239 LP GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM Sbjct: 183 ELPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM 242 Query: 240 VAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGT 299 VAPD+TT+E+LR RPHAPTGA WDAA+ W+QLRTDPGA FDTEVHLDAAELSPFVTWGT Sbjct: 243 VAPDDTTFEFLRGRPHAPTGADWDAAVEAWRQLRTDPGAEFDTEVHLDAAELSPFVTWGT 302 Query: 300 NPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRI 359 NPGQGVPL VPDPELI D+GERQAAEKAL YM L+ G AMRD+AVD VFVGSCTNGRI Sbjct: 303 NPGQGVPLSGAVPDPELIVDEGERQAAEKALTYMGLQAGTAMRDVAVDTVFVGSCTNGRI 362 Query: 360 EDLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLG 419 EDLRVVA+VLRGR+VA G+RML+VPGSMRVRAQAE EGL +F AGAEWRQAGCSMCLG Sbjct: 363 EDLRVVADVLRGRRVADGIRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLG 422 Query: 420 MNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 MNPDQL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLS+PADL+ Sbjct: 423 MNPDQLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLS 476 >sp|A4TE23|LEUC_MYCGI Tax_Id=350054 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium gilvum] Length = 481 Score = 811 bits (2095), Expect = 0.0 Identities = 401/470 (85%), Positives = 422/470 (89%), Gaps = 4/470 (0%) Query: 7 EARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 62 + RTLAEKVW DHVVVSG E PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD Sbjct: 6 QPRTLAEKVWSDHVVVSGSGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 65 Query: 63 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQL 122 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNC EFGIRLHPMGDVEQGIVH++GPQL Sbjct: 66 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDVEQGIVHIIGPQL 125 Query: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 GLTQPG T+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDG LP Sbjct: 126 GLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELP 185 Query: 183 AGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 GVS GTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGM+AP Sbjct: 186 PGVSAKDVILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMIAP 245 Query: 243 DETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPG 302 DETT+E+L+ RPHAP GA WDAA+ W+ LRTD GA FDTEV++DAA LSPFVTWGTNPG Sbjct: 246 DETTFEFLKGRPHAPQGADWDAAVEAWKLLRTDEGAQFDTEVYIDAASLSPFVTWGTNPG 305 Query: 303 QGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDL 362 QGVPL +VPDPE+I D+GER A EKALAYMDL PG MR+I VDAVFVGSCTNGRIEDL Sbjct: 306 QGVPLSDSVPDPEMIFDEGERSAVEKALAYMDLRPGTPMREIPVDAVFVGSCTNGRIEDL 365 Query: 363 RVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNP 422 RVVA+VLRGR VA VRML+VPGSMRVRAQAE EGLGE+FT AGAEWRQAGCSMCLGMNP Sbjct: 366 RVVADVLRGRTVADDVRMLVVPGSMRVRAQAEAEGLGEIFTAAGAEWRQAGCSMCLGMNP 425 Query: 423 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 DQLAPGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLS+PADL Sbjct: 426 DQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADL 475 >tr|A0QUY9|A0QUY9_MYCS2 Tax_Id=246196 (leuC)SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Mycobacterium smegmatis] Length = 484 Score = 803 bits (2074), Expect = 0.0 Identities = 394/468 (84%), Positives = 418/468 (89%), Gaps = 4/468 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 64 RTLAEKVWDDHVV G E PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT Sbjct: 12 RTLAEKVWDDHVVARGEGEGTAKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 71 Query: 65 IATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGL 124 IATEDHNVPT+DIDKPIADPVSRTQVETLRRNC EFGIRLHPMGD EQGIVH++GPQLGL Sbjct: 72 IATEDHNVPTIDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLGL 131 Query: 125 TQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAG 184 TQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL L+PFKTMAVNVDG LP G Sbjct: 132 TQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPPG 191 Query: 185 VSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDE 244 VS GTGGGQGHVIEYRGSAI SLSMEGRMTICNMSIEAGARAGMVAPDE Sbjct: 192 VSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDE 251 Query: 245 TTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQG 304 TT+E+L+ RPHAP GA WDAA+ W +LRTD GA FDTEV++DA+ LSPFVTWGTNPGQG Sbjct: 252 TTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEVYIDASTLSPFVTWGTNPGQG 311 Query: 305 VPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRV 364 VPL VPDPELI D+G RQAAEKALAYMDL PG MRDIAVD VFVGSCTNGRIEDLRV Sbjct: 312 VPLSEAVPDPELIVDEGARQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLRV 371 Query: 365 VAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQ 424 VA+VLRGRKVA GVRMLIVPGSMRVRAQAE EGL ++FT AGA+WRQAGCSMCLGMNPDQ Sbjct: 372 VADVLRGRKVADGVRMLIVPGSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPDQ 431 Query: 425 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 L+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG L++PADL Sbjct: 432 LSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADL 479 >tr|C1B2N0|C1B2N0_RHOOB Tax_Id=632772 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus opacus] Length = 473 Score = 781 bits (2016), Expect = 0.0 Identities = 376/472 (79%), Positives = 413/472 (87%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 M +ARTLAEKVWDDHVVV G + PDLIYIDLHLVHEVTSPQAFDGLRLAGRP+RR Sbjct: 1 MEKMAEKARTLAEKVWDDHVVVRGEGDNPDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 PDLTIATEDHNVPTVDIDKPIADPVS+TQV+TLRRNC EFG+RLHPMG+++QGIVHVVGP Sbjct: 61 PDLTIATEDHNVPTVDIDKPIADPVSKTQVDTLRRNCEEFGVRLHPMGNIDQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHV+ATQTL LRPF+TMA+ VDG Sbjct: 121 QLGLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLRPFRTMAITVDGE 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 LP GV+ GTGGGQG+V+EYRG AI +SME RMTICNMSIEAGARAGM+ Sbjct: 181 LPEGVTSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKMSMEARMTICNMSIEAGARAGMI 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APDE TYE+++ RPHAP GA WDAA+ W+QL+TD GAVFD EVH+DA+ L+PFVTWGTN Sbjct: 241 APDEITYEFIKGRPHAPKGADWDAAVAAWEQLKTDEGAVFDNEVHIDASALTPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQG+PL VPDPE I D+ ER AAEKAL YM LE G +R++A+D VFVGSCTNGRIE Sbjct: 301 PGQGLPLGEAVPDPEQIVDESERHAAEKALTYMGLEAGTPLREVAIDTVFVGSCTNGRIE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLR VA+VLRGR VA GVRMLIVPGSMRVRAQAEKEGLGE+FT AGAEWRQAGCSMCLGM Sbjct: 361 DLRAVADVLRGRHVADGVRMLIVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 NPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLSAP DL Sbjct: 421 NPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPTDL 472 >sp|Q5YRY0|LEUC_NOCFA Tax_Id=37329 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Nocardia farcinica] Length = 474 Score = 780 bits (2014), Expect = 0.0 Identities = 376/469 (80%), Positives = 411/469 (87%), Gaps = 4/469 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLT 64 RTLAEKVW++HVV G E PDLIYIDLHLVHEVTSPQAFDGLR AGRPVRRPDLT Sbjct: 6 RTLAEKVWEEHVVARGEGEGASREPDLIYIDLHLVHEVTSPQAFDGLRAAGRPVRRPDLT 65 Query: 65 IATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGL 124 IATEDHNVPTVDIDKPIADP+SRTQVETLRRNCAEFGIRLHPMGD+EQGIVHVVGPQLGL Sbjct: 66 IATEDHNVPTVDIDKPIADPISRTQVETLRRNCAEFGIRLHPMGDLEQGIVHVVGPQLGL 125 Query: 125 TQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAG 184 TQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTL LRPFKTMA+N+DG+LP G Sbjct: 126 TQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLSLRPFKTMAINIDGQLPPG 185 Query: 185 VSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDE 244 V+ GTGGGQG+V+EYRG A+ ++SME RMT+CNMSIEAGARAGM+APDE Sbjct: 186 VTSKDVILAVIAQIGTGGGQGYVLEYRGEAVRAMSMEARMTMCNMSIEAGARAGMIAPDE 245 Query: 245 TTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQG 304 TYE+L+ RPHAP GA WDAA+ W LRTD GAVFD EVH+DA+ LSPFVTWGTNPGQG Sbjct: 246 VTYEFLKGRPHAPKGADWDAAVAAWDALRTDEGAVFDAEVHIDASSLSPFVTWGTNPGQG 305 Query: 305 VPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRV 364 PL ATVPDP D+ R+AA KAL YMDL PG +R++AVD VFVGSCTNGRIEDLR Sbjct: 306 APLSATVPDPADFADETAREAAAKALRYMDLTPGTPLREVAVDTVFVGSCTNGRIEDLRA 365 Query: 365 VAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQ 424 AE+L+GR+VA GVRML+VPGSMRVRAQAEKEGLGE+FT AGAEWRQAGCSMCLGMNPDQ Sbjct: 366 AAEILKGRRVAEGVRMLVVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGMNPDQ 425 Query: 425 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 L PG+RCA+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+PADL+ Sbjct: 426 LEPGQRCASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADLD 474 >tr|C0ZXN1|C0ZXN1_RHOE4 Tax_Id=234621 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus erythropolis] Length = 473 Score = 780 bits (2014), Expect = 0.0 Identities = 378/467 (80%), Positives = 412/467 (88%) Query: 6 REARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTI 65 ++ARTLAEKVWDDHVVV G + PDLIYIDLHLVHEVTSPQAFDGLRLAGRP+RRPDLTI Sbjct: 6 QKARTLAEKVWDDHVVVKGEGQDPDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRRPDLTI 65 Query: 66 ATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLT 125 ATEDHNVPT+DIDKPIADPVS+TQV+TLRRNC EFG+RLH MGD++QGIVHVVGPQLGLT Sbjct: 66 ATEDHNVPTIDIDKPIADPVSKTQVDTLRRNCEEFGVRLHRMGDLDQGIVHVVGPQLGLT 125 Query: 126 QPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGV 185 QPG T+VCGDSHTSTHGAFGALAMGIGTSEVEHV+ATQTL LRPFKTMA+ VDG LP GV Sbjct: 126 QPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFKTMAITVDGELPPGV 185 Query: 186 SXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDET 245 + GTGGGQG+V+EYRG AI LSME RMTICNMSIEAGARAGM+APDET Sbjct: 186 TSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKLSMEARMTICNMSIEAGARAGMIAPDET 245 Query: 246 TYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGV 305 TYE+++ RPHAP+GA+WD A+ W+ L+TD GA FD EVH+DA+ L+PFVTWGTNPGQG Sbjct: 246 TYEFIKGRPHAPSGAEWDEAVAAWELLKTDEGAEFDNEVHIDASALTPFVTWGTNPGQGA 305 Query: 306 PLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVV 365 PL VPDPELI D+ ERQAAEKAL YM L+ G A+RD+AVD VFVGSCTNGRIEDLR V Sbjct: 306 PLGDRVPDPELIVDESERQAAEKALTYMGLDAGMALRDVAVDTVFVGSCTNGRIEDLRAV 365 Query: 366 AEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQL 425 AEVL GR VA GVRMLIVPGSMRVRAQAE EGLGE+FT AGAEWRQAGCSMCLGMNPDQL Sbjct: 366 AEVLEGRHVAEGVRMLIVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNPDQL 425 Query: 426 APGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 APGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLSAPADL Sbjct: 426 APGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPADL 472 >sp|B1MDQ1|LEUC_MYCA9 Tax_Id=561007 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Mycobacterium abscessus] Length = 480 Score = 775 bits (2002), Expect = 0.0 Identities = 379/471 (80%), Positives = 409/471 (86%), Gaps = 4/471 (0%) Query: 6 REARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRP 61 ++ RTLAEKVWD HVVV G E PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRP Sbjct: 5 QQPRTLAEKVWDSHVVVRGTGEGEAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRQVRRP 64 Query: 62 DLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQ 121 DLTIATEDHNVPT+DIDKPIADPVSRTQVETLR+NC EFGIRLHPMGD EQGIVHVVGPQ Sbjct: 65 DLTIATEDHNVPTIDIDKPIADPVSRTQVETLRKNCEEFGIRLHPMGDAEQGIVHVVGPQ 124 Query: 122 LGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRL 181 LGLTQPG T+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPF+TMA+N+DG L Sbjct: 125 LGLTQPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAINIDGSL 184 Query: 182 PAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVA 241 P GV+ GTGGGQG+V+EYRG A+E +SME RMT+CNMSIEAGARAGMVA Sbjct: 185 PTGVTSKDVILAVIAKIGTGGGQGYVLEYRGQAVEEMSMEARMTMCNMSIEAGARAGMVA 244 Query: 242 PDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNP 301 PDETTY YL++RPHAP G WDAA+ W LRTD GA FD EVH+DA+ L+PFVTWGTNP Sbjct: 245 PDETTYAYLKDRPHAPKGQLWDAAVAEWDSLRTDEGAQFDAEVHIDASTLTPFVTWGTNP 304 Query: 302 GQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIED 361 GQGVPL A VPDPEL+ D+ ER AAEKAL YMDL PG MR+I VD VFVGSCTNGRIED Sbjct: 305 GQGVPLGADVPDPELMADEEERLAAEKALTYMDLTPGTPMREIPVDTVFVGSCTNGRIED 364 Query: 362 LRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMN 421 LR VA+VLR RKVA GV MLIVPGSMRVRAQAE EGLGE+F AGA+WRQAGCSMCLGMN Sbjct: 365 LRAVADVLRDRKVAAGVTMLIVPGSMRVRAQAESEGLGEIFAAAGAQWRQAGCSMCLGMN 424 Query: 422 PDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 PDQL+PG+RCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRG LS+PADL Sbjct: 425 PDQLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLSSPADL 475 >tr|Q0S2G4|Q0S2G4_RHOSR Tax_Id=101510 (leuC2)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Rhodococcus sp.] Length = 500 Score = 775 bits (2001), Expect = 0.0 Identities = 373/466 (80%), Positives = 411/466 (88%) Query: 7 EARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIA 66 +ARTLAEKVWDDHVVV G + PDLIYIDLHLVHEVTSPQAFDGLRLAGRP+RRPDLTIA Sbjct: 34 KARTLAEKVWDDHVVVRGEGDNPDLIYIDLHLVHEVTSPQAFDGLRLAGRPLRRPDLTIA 93 Query: 67 TEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQ 126 TEDHNVPTVDIDKPIADPVS+TQV+TLRRNC EFG+RLHPMG+++QGIVHVVGPQLGLTQ Sbjct: 94 TEDHNVPTVDIDKPIADPVSKTQVDTLRRNCEEFGVRLHPMGNIDQGIVHVVGPQLGLTQ 153 Query: 127 PGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVS 186 PGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHV+ATQTL LRPF+TMA+ VDG LP GV+ Sbjct: 154 PGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFRTMAITVDGELPDGVT 213 Query: 187 XXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETT 246 GTGGGQG+V+EYRG AI +SME RMT+CNMSIEAGARAGM+APDE T Sbjct: 214 SKDLILAVIAKIGTGGGQGYVLEYRGEAIRKMSMEARMTVCNMSIEAGARAGMIAPDEIT 273 Query: 247 YEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVP 306 YE+++ RPHAP GA WDAA+ W+QL+TD GAVFD EVH+DA+ L+PFVTWGTNPGQG+P Sbjct: 274 YEFIKGRPHAPKGADWDAAVEAWEQLKTDEGAVFDNEVHIDASSLTPFVTWGTNPGQGLP 333 Query: 307 LCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVA 366 L VP+P I D+ ER AAEKAL YM LE G +R++A+D VFVGSCTNGRIEDLR VA Sbjct: 334 LGEAVPNPAEIVDESERHAAEKALTYMGLEAGTPLREVAIDTVFVGSCTNGRIEDLRAVA 393 Query: 367 EVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLA 426 +VLRGR VA GVRMLIVPGSMRVRAQAEKEGLGE+FT AGAEWRQAGCSMCLGMNPDQLA Sbjct: 394 DVLRGRHVADGVRMLIVPGSMRVRAQAEKEGLGEIFTAAGAEWRQAGCSMCLGMNPDQLA 453 Query: 427 PGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 PGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLSAP DL Sbjct: 454 PGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPTDL 499 >tr|C3JSK4|C3JSK4_RHOER Tax_Id=596309 (leuC)SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Rhodococcus erythropolis SK121] Length = 473 Score = 774 bits (1998), Expect = 0.0 Identities = 375/467 (80%), Positives = 410/467 (87%) Query: 6 REARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTI 65 ++ARTLAEKVWDDHVVV G + PDLIYIDLHLVHEVTSPQAFDGLRLAGR +RRPDLTI Sbjct: 6 QKARTLAEKVWDDHVVVKGEGQDPDLIYIDLHLVHEVTSPQAFDGLRLAGRQLRRPDLTI 65 Query: 66 ATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLT 125 ATEDHNVPT+DIDKPIADPVS+TQV+TLRRNC EFG+RLH MGD++QGIVHVVGPQLGLT Sbjct: 66 ATEDHNVPTIDIDKPIADPVSKTQVDTLRRNCEEFGVRLHRMGDLDQGIVHVVGPQLGLT 125 Query: 126 QPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGV 185 QPG T+VCGDSHTSTHGAFGALAMGIGTSEVEHV+ATQTL LRPFKTMA+ VDG LP GV Sbjct: 126 QPGTTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLRPFKTMAITVDGELPPGV 185 Query: 186 SXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDET 245 + GTGGGQG+V+EYRG AI LSME RMTICNMSIEAGARAGM+APDET Sbjct: 186 TSKDLILAVIAKIGTGGGQGYVLEYRGEAIRKLSMEARMTICNMSIEAGARAGMIAPDET 245 Query: 246 TYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGV 305 TYE+++ RPHAP+GA+WD A+ W+ L+TD GA FD EVH+DA+ L+PFVTWGTNPGQG Sbjct: 246 TYEFIKGRPHAPSGAEWDEAVAAWELLKTDEGAEFDNEVHIDASALTPFVTWGTNPGQGA 305 Query: 306 PLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVV 365 PL VPDPELI D+ ERQAAEKAL YM L+ G +RD++VD VFVGSCTNGRIEDLR V Sbjct: 306 PLGDRVPDPELIVDESERQAAEKALTYMGLDAGMPLRDVSVDTVFVGSCTNGRIEDLRAV 365 Query: 366 AEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQL 425 AEVL GR VA GVRMLIVPGSMRVRAQAE EGLGE+FT AGAEWRQAGCSMCLGMNPDQL Sbjct: 366 AEVLEGRHVAEGVRMLIVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNPDQL 425 Query: 426 APGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 APGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLSAPADL Sbjct: 426 APGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSAPADL 472 >tr|D0LC33|D0LC33_GORB4 Tax_Id=526226 SubName: Full=3-isopropylmalate dehydratase, large subunit;[Gordonia bronchialis] Length = 477 Score = 771 bits (1991), Expect = 0.0 Identities = 379/477 (79%), Positives = 412/477 (86%), Gaps = 5/477 (1%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEA-----PDLIYIDLHLVHEVTSPQAFDGLRLAG 55 M+ T + RTLAEKVW+DHVVV G +A PDLIYIDLHLVHEVTSPQAF+GLRLAG Sbjct: 1 MSNSTAKPRTLAEKVWEDHVVVPGEADASGAQNPDLIYIDLHLVHEVTSPQAFEGLRLAG 60 Query: 56 RPVRRPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIV 115 RPVRRPDLTIATEDHNVPT+DI PIAD VSRTQVETLRRNCAEFGIRLHPMGD EQGIV Sbjct: 61 RPVRRPDLTIATEDHNVPTLDIFSPIADEVSRTQVETLRRNCAEFGIRLHPMGDAEQGIV 120 Query: 116 HVVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAV 175 HVVGPQLGLTQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTL LRPFKTMA+ Sbjct: 121 HVVGPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLSLRPFKTMAI 180 Query: 176 NVDGRLPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGA 235 VDG LP+GV+ GTGGGQG+V+EYRG AIE LSME RMTICNMSIEAGA Sbjct: 181 TVDGELPSGVTSKDLILAVIAKIGTGGGQGYVLEYRGPAIEKLSMEARMTICNMSIEAGA 240 Query: 236 RAGMVAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFV 295 RAGM+APD+ TY++L+ RP+APTGA WDAA+ YW LRTDPGA FD EVH+DA+ L+PFV Sbjct: 241 RAGMIAPDQVTYDFLKGRPNAPTGADWDAAVQYWDSLRTDPGAEFDAEVHIDASALTPFV 300 Query: 296 TWGTNPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCT 355 TWGTNPGQG PL A VPDP +GD+ AA KAL YMDL PG +RDI VD VFVGSCT Sbjct: 301 TWGTNPGQGAPLGAVVPDPADMGDENASTAASKALEYMDLTPGMPLRDIKVDTVFVGSCT 360 Query: 356 NGRIEDLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCS 415 NGRIEDLR VAE+L+GRKVA G+RMLIVPGSMRVRAQAE EGLG++F AGAEWRQAGCS Sbjct: 361 NGRIEDLRAVAEILKGRKVAEGMRMLIVPGSMRVRAQAEDEGLGDIFEHAGAEWRQAGCS 420 Query: 416 MCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 MCLGMNPDQL+PGERCA+TSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLS+P DL Sbjct: 421 MCLGMNPDQLSPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPDDL 477 >tr|C7MXF5|C7MXF5_SACVD Tax_Id=471857 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Saccharomonospora viridis] Length = 471 Score = 766 bits (1978), Expect = 0.0 Identities = 375/468 (80%), Positives = 408/468 (87%) Query: 6 REARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTI 65 + RTLAEKVWD HVV G PDL+YIDLHLVHEVTSPQAFDGLRLAGR VRRPDLTI Sbjct: 4 KRGRTLAEKVWDAHVVRRGEGAEPDLLYIDLHLVHEVTSPQAFDGLRLAGRKVRRPDLTI 63 Query: 66 ATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLT 125 ATEDHNVPT ID PIADPVSRTQVETLRRNC EFGIRLHPMGD EQGIVHV+GPQLGLT Sbjct: 64 ATEDHNVPTTGIDLPIADPVSRTQVETLRRNCEEFGIRLHPMGDDEQGIVHVIGPQLGLT 123 Query: 126 QPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGV 185 QPGMT+VCGDSHTSTHGAFGA+A GIGTSEVEHVLATQTLP+RPFKTMAVNVDG+L GV Sbjct: 124 QPGMTVVCGDSHTSTHGAFGAMAFGIGTSEVEHVLATQTLPMRPFKTMAVNVDGQLRPGV 183 Query: 186 SXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDET 245 + GTGGGQGHVIEYRGS IE+LSME RMTICNMSIEAGARAGM+APDET Sbjct: 184 TAKDIILAVIAKIGTGGGQGHVIEYRGSTIEALSMEARMTICNMSIEAGARAGMIAPDET 243 Query: 246 TYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGV 305 T+ YL++RPHAP GA WDAAL W++LRTD AVFDTEVHLDA+EL+PFVTWGTNPGQG+ Sbjct: 244 TFAYLKDRPHAPQGADWDAALAEWRELRTDDDAVFDTEVHLDASELTPFVTWGTNPGQGL 303 Query: 306 PLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVV 365 PL +VPDPE + D+ ER AAEKAL+YMDL+PG +R+IAVD VF+GSCTNGR+EDLR Sbjct: 304 PLSESVPDPEQMTDETERLAAEKALSYMDLKPGTPLREIAVDTVFLGSCTNGRLEDLRAA 363 Query: 366 AEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQL 425 AEVL+GRKVA GVRML+VPGSMRVR AE+EGL EVFT AGAEWR AGCSMCLGMNPDQL Sbjct: 364 AEVLKGRKVADGVRMLVVPGSMRVRKAAEEEGLHEVFTEAGAEWRAAGCSMCLGMNPDQL 423 Query: 426 APGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 PGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+P DL+ Sbjct: 424 KPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPEDLD 471 >tr|C6WG49|C6WG49_ACTMD Tax_Id=446462 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Actinosynnema mirum] Length = 472 Score = 754 bits (1946), Expect = 0.0 Identities = 368/465 (79%), Positives = 403/465 (86%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 +RTLAEKVW+ HVV G PDL+YIDLHL+HEVTSPQAFDGLRLAGR +RRPDLTIAT Sbjct: 2 SRTLAEKVWEAHVVRHGSGAEPDLLYIDLHLLHEVTSPQAFDGLRLAGRRLRRPDLTIAT 61 Query: 68 EDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQP 127 EDHNVPTVDI+ PIADPVSRTQVETLRRNCAEFG+RLHPMGD EQGIVHVVGPQLGLTQP Sbjct: 62 EDHNVPTVDIELPIADPVSRTQVETLRRNCAEFGVRLHPMGDAEQGIVHVVGPQLGLTQP 121 Query: 128 GMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSX 187 GMT+VCGDSHTSTHGAFGALA GIGTSEVEHV+ATQTLPLRPFKTMA+NV+G L GV+ Sbjct: 122 GMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQTLPLRPFKTMAINVEGSLRPGVTA 181 Query: 188 XXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTY 247 GTGGGQG+V+EYRGSAI +LSME RMT+CNMSIEAGARAGM+APD+TT+ Sbjct: 182 KDVILAVIAKIGTGGGQGYVLEYRGSAISALSMEARMTVCNMSIEAGARAGMIAPDQTTF 241 Query: 248 EYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPL 307 +Y++ RPHAP+GA WDAA+ YW L TD GA FD EV LDA EL+PFVTWGTNPGQG+PL Sbjct: 242 DYIKGRPHAPSGADWDAAVEYWSTLATDEGAEFDAEVTLDADELTPFVTWGTNPGQGLPL 301 Query: 308 CATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAE 367 A+VPDPE I D+ ER AAEKAL+YM LE G +RDI VD VF+GSCTNGRIEDLR A+ Sbjct: 302 GASVPDPEAIADENERVAAEKALSYMGLEAGTPLRDIRVDTVFLGSCTNGRIEDLRAAAD 361 Query: 368 VLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAP 427 VLRG VA GVRML+VPGSMRVRAQAE EGL EVF AGAEWRQAGCSMCLGMNPDQL P Sbjct: 362 VLRGHHVADGVRMLVVPGSMRVRAQAETEGLHEVFQAAGAEWRQAGCSMCLGMNPDQLKP 421 Query: 428 GERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 GER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+PADL Sbjct: 422 GERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 466 >tr|C2AUC8|C2AUC8_TSUPA Tax_Id=521096 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Tsukamurella paurometabola DSM 20162] Length = 481 Score = 743 bits (1918), Expect = 0.0 Identities = 365/470 (77%), Positives = 398/470 (84%), Gaps = 4/470 (0%) Query: 7 EARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPD 62 + RT+AEKVWD HVVV G E PDLIYIDLHLVHEVTSPQAFDGLRLAGR VRRPD Sbjct: 2 QPRTMAEKVWDQHVVVKGEGEGASREPDLIYIDLHLVHEVTSPQAFDGLRLAGRTVRRPD 61 Query: 63 LTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQL 122 LTIATEDHNVPT + +PIAD VSRTQVETLRRNCAEFG+RLH MGD EQGIVHV+GPQL Sbjct: 62 LTIATEDHNVPTDTLVQPIADEVSRTQVETLRRNCAEFGVRLHSMGDGEQGIVHVMGPQL 121 Query: 123 GLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLP 182 GLTQPGMT+VCGDSHTSTHGAFGA+AMGIGTSEVEHVLATQTL L+PFKTMA+NV G L Sbjct: 122 GLTQPGMTVVCGDSHTSTHGAFGAIAMGIGTSEVEHVLATQTLALKPFKTMAINVSGELQ 181 Query: 183 AGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAP 242 GV+ GTGGGQG+V+EYRGSAIE LSME RMTICNMSIEAGARAGM+AP Sbjct: 182 PGVTSKDLILAIIAKIGTGGGQGYVLEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAP 241 Query: 243 DETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPG 302 D+ TY+Y+R R HAP G WD A+ W LRTD GAVFD E+ +D L+PFVTWGTNPG Sbjct: 242 DQITYDYIRGREHAPQGELWDEAVAAWDALRTDEGAVFDAEIDIDGGALTPFVTWGTNPG 301 Query: 303 QGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDL 362 QG+PL +VPDP G DGER+ A KAL YM LEPG +R+IAVD VFVGSCTNGRIEDL Sbjct: 302 QGLPLSGSVPDPASFGSDGERETAAKALQYMGLEPGTPLREIAVDTVFVGSCTNGRIEDL 361 Query: 363 RVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNP 422 R VAE+LRGRKVA GVRML+VPGSMRVRAQAE+EGLG++F AGAEWRQAGCSMCLGMNP Sbjct: 362 RAVAEILRGRKVADGVRMLVVPGSMRVRAQAEEEGLGQIFLDAGAEWRQAGCSMCLGMNP 421 Query: 423 DQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 DQLAPGER A+TSNRNFEGRQGKG RTHLVSPAVAAATAVRGTLS+PADL Sbjct: 422 DQLAPGERSASTSNRNFEGRQGKGSRTHLVSPAVAAATAVRGTLSSPADL 471 >sp|A4FMP2|LEUC_SACEN Tax_Id=405948 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Saccharopolyspora erythraea] Length = 467 Score = 735 bits (1897), Expect = 0.0 Identities = 357/465 (76%), Positives = 394/465 (84%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 +TLAEKVW+ H+V G PDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLT+ATE Sbjct: 3 KTLAEKVWEAHIVRRGEGYEPDLLYIDLHLVHEVTSPQAFEGLRLAGRQVRRPDLTLATE 62 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHNVPT ID PIADPVSRTQV+TLRRNC EFGIRLHPMGD EQGIVHVVGPQLGLTQPG Sbjct: 63 DHNVPTTGIDLPIADPVSRTQVDTLRRNCEEFGIRLHPMGDAEQGIVHVVGPQLGLTQPG 122 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 T+VCGDSHTSTHGAFGALA GIGTSEVEHVLATQTLPLRPFKTMA+N++G L GV+ Sbjct: 123 TTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLRPFKTMAINIEGTLRPGVTSK 182 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQG+V+EYRGSA+E +SME RMT+CNMSIEAGARAGM+APDETT+ Sbjct: 183 DVILAVIAKIGTGGGQGYVLEYRGSAVEKMSMEARMTMCNMSIEAGARAGMIAPDETTFA 242 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL+ RPHAP G +WDAA+ YW+ LRTD A FD EV LDA EL+PFVTWGTNPGQG+PL Sbjct: 243 YLQGRPHAPEGTEWDAAVEYWKTLRTDEDAEFDAEVTLDADELTPFVTWGTNPGQGLPLG 302 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 A +PDP I D+ ER A EKAL YM LE G +R++AVD VF+GSCTNGRIEDLR A+V Sbjct: 303 ARIPDPAAIADESERFATEKALDYMGLEAGTPLREVAVDTVFLGSCTNGRIEDLRAAADV 362 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 L+GRKVA VRML+VPGSMRVR QAE EGL EVFT AGAEWR AGCSMCLGMNPDQL PG Sbjct: 363 LKGRKVASEVRMLVVPGSMRVRKQAEAEGLNEVFTAAGAEWRSAGCSMCLGMNPDQLTPG 422 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+P DL+ Sbjct: 423 ERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPEDLD 467 >sp|Q47SA3|LEUC_THEFY Tax_Id=269800 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Thermobifida fusca] Length = 465 Score = 731 bits (1886), Expect = 0.0 Identities = 358/465 (76%), Positives = 396/465 (85%), Gaps = 1/465 (0%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 ART+AEKVW++HVV E PDL+YIDLHL+HEVTSPQAF+GLRLA R +RRPDLTIAT Sbjct: 2 ARTMAEKVWEEHVVRRAEGE-PDLLYIDLHLIHEVTSPQAFEGLRLANRKLRRPDLTIAT 60 Query: 68 EDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQP 127 EDHNVPT +I PIADPVSRTQVETLR+N AEFG+RLHPMGD++QGIVHV+GPQLGLTQP Sbjct: 61 EDHNVPTENIFLPIADPVSRTQVETLRKNAAEFGVRLHPMGDIDQGIVHVIGPQLGLTQP 120 Query: 128 GMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSX 187 GMTIVCGDSHTSTHGAFGALA GIGTS+VEHV+ATQTLP+ PFKTMAVNV+G+L GV+ Sbjct: 121 GMTIVCGDSHTSTHGAFGALAFGIGTSQVEHVMATQTLPMTPFKTMAVNVEGKLKPGVTA 180 Query: 188 XXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTY 247 GTGGGQGHVIEYRG AI SLSME RMTICNMSIEAGARAGM+APD+TT+ Sbjct: 181 KDIILAVIAQIGTGGGQGHVIEYRGEAIRSLSMEARMTICNMSIEAGARAGMIAPDQTTF 240 Query: 248 EYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPL 307 +YL+ RPHAP G WD A+ YW+ L TD GAVFD EV L+A ELSPFVTWGTNPGQGVPL Sbjct: 241 DYLKGRPHAPKGELWDQAVEYWKTLPTDEGAVFDKEVFLNADELSPFVTWGTNPGQGVPL 300 Query: 308 CATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAE 367 + VPDPE D ER AAEKALAYMDL+PG MRDI +D VF+GSCTNGRIEDLR AE Sbjct: 301 DSVVPDPESFTDPVERAAAEKALAYMDLKPGTRMRDIKIDTVFLGSCTNGRIEDLRAAAE 360 Query: 368 VLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAP 427 VL+GRKVA GVRML+VPGS RV+ QA EGL E+F AGAEWR+AGCSMCLGMNPD L P Sbjct: 361 VLKGRKVADGVRMLVVPGSQRVKQQAAAEGLDEIFKAAGAEWREAGCSMCLGMNPDTLKP 420 Query: 428 GERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 GER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+PADL Sbjct: 421 GERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 465 >tr|C1YHU3|C1YHU3_NOCDA Tax_Id=446468 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] Length = 468 Score = 726 bits (1875), Expect = 0.0 Identities = 356/465 (76%), Positives = 398/465 (85%), Gaps = 1/465 (0%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 ART+AEKVW++HVV E PDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLTIAT Sbjct: 2 ARTMAEKVWEEHVVRRADGE-PDLLYIDLHLVHEVTSPQAFEGLRLAGRSVRRPDLTIAT 60 Query: 68 EDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQP 127 EDHNVPT D+ PIADPVSR QVETLR+NC++FG+RLHPMGD+EQG+VHVVGPQLGLTQP Sbjct: 61 EDHNVPTQDLLAPIADPVSRKQVETLRKNCSDFGVRLHPMGDIEQGVVHVVGPQLGLTQP 120 Query: 128 GMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSX 187 GMTIVCGDSHTSTHGAFGALA GIGTS+VEHVLATQTLP+ PFKTMAV V+G L GVS Sbjct: 121 GMTIVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPMAPFKTMAVTVNGTLRPGVSA 180 Query: 188 XXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTY 247 GTGGGQG+VIEYRG AIE+LSME RMT+CNMSIEAGARAGM+APD+TT+ Sbjct: 181 KDVILAVIAKIGTGGGQGYVIEYRGEAIEALSMEARMTVCNMSIEAGARAGMIAPDQTTF 240 Query: 248 EYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPL 307 +Y+R R HAP G +DAA+ +W+ LRTD GAVFD EV LDA ELSPFVTWGTNPGQGVPL Sbjct: 241 DYIRGRAHAPQGEDFDAAVEHWKSLRTDEGAVFDAEVVLDADELSPFVTWGTNPGQGVPL 300 Query: 308 CATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAE 367 A+VPDP D R AAEKALAYMDL G MR+++VD VF+GSCTNGRIEDLR AE Sbjct: 301 DASVPDPASFEDPSARAAAEKALAYMDLAAGTPMREVSVDTVFLGSCTNGRIEDLRAAAE 360 Query: 368 VLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAP 427 ++RGR+VA GVRML+VPGSMRV+ QA +EGLG VF AGAEWR+AGCSMCLGMNPDQL P Sbjct: 361 IIRGRRVAEGVRMLVVPGSMRVKEQANEEGLGRVFEEAGAEWREAGCSMCLGMNPDQLKP 420 Query: 428 GERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 GER A+TSNRNFEGRQG+GGRTHLVSP VAAATAVRGTLS+PADL Sbjct: 421 GERSASTSNRNFEGRQGRGGRTHLVSPQVAAATAVRGTLSSPADL 465 >tr|B0REY2|B0REY2_CLAMS Tax_Id=31964 (leuC)SubName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;[Clavibacter michiganensis subsp. sepedonicus] Length = 493 Score = 726 bits (1873), Expect = 0.0 Identities = 352/472 (74%), Positives = 391/472 (82%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 M + A+TLAEKVW DH+V G + PDL+YIDLHLVHEVTSPQAFDGLRLAGRPVRR Sbjct: 1 MRRAVQPAKTLAEKVWADHLVAEGEDGTPDLLYIDLHLVHEVTSPQAFDGLRLAGRPVRR 60 Query: 61 PDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGP 120 PDLTIATEDHN PT+ ID+PIAD SRTQ+ TLRRN EFGIRLH +GD+EQGIVHVVGP Sbjct: 61 PDLTIATEDHNTPTIGIDRPIADLTSRTQIHTLRRNAEEFGIRLHSLGDIEQGIVHVVGP 120 Query: 121 QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR 180 QLGLT PG+T+VCGDSHTSTHGAFGA+A GIGTSEVEHV+ATQTLPL+PFKTMAV V+G Sbjct: 121 QLGLTMPGITVVCGDSHTSTHGAFGAMAFGIGTSEVEHVMATQTLPLQPFKTMAVTVEGT 180 Query: 181 LPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV 240 L GV+ GTGGGQG+V+EYRGSAI SLSMEGRMTICNMSIEAGARAGMV Sbjct: 181 LRPGVTAKDIILAVIAQIGTGGGQGYVLEYRGSAIRSLSMEGRMTICNMSIEAGARAGMV 240 Query: 241 APDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTN 300 APD+TTY+YLR RPHAPTGA WD A+ YW L TD AVFD EV LDA L PFVTWGTN Sbjct: 241 APDQTTYDYLRGRPHAPTGADWDEAVAYWDTLATDDDAVFDAEVFLDADTLEPFVTWGTN 300 Query: 301 PGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIE 360 PGQGV L VPDP + D ER AAE+ALAYMDL PG M++IAVD VF+GSCTN R+E Sbjct: 301 PGQGVSLSEPVPDPAAVADPNERAAAERALAYMDLAPGTPMKEIAVDTVFIGSCTNSRVE 360 Query: 361 DLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGM 420 DLR AE++RGR A GVR+++VPGS RVR +AE EG+ +VFT GAEWR AGCSMCLGM Sbjct: 361 DLRAAAEIVRGRTKAEGVRVMVVPGSARVRLEAEAEGIDKVFTDFGAEWRFAGCSMCLGM 420 Query: 421 NPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 NPDQLAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGTLS+P DL Sbjct: 421 NPDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSPWDL 472 >sp|A0LVA3|LEUC_ACIC1 Tax_Id=351607 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Acidothermus cellulolyticus] Length = 473 Score = 725 bits (1871), Expect = 0.0 Identities = 358/465 (76%), Positives = 390/465 (83%), Gaps = 1/465 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 RT+AEK+W++HVV E PDL+YIDLHL+HEVTSPQAFDGLRLAGR VRRPDLTIATE Sbjct: 10 RTMAEKIWEEHVVRRADGE-PDLLYIDLHLIHEVTSPQAFDGLRLAGRRVRRPDLTIATE 68 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHNVPT DIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGD EQGIVHV+GPQLGLTQPG Sbjct: 69 DHNVPTTDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDREQGIVHVIGPQLGLTQPG 128 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 MTIVCGDSHTSTHGAFGALA GIGTSEVEHVLATQTLP KTMAV VDG L GV+ Sbjct: 129 MTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPQYKPKTMAVTVDGTLRPGVTSK 188 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQGHVIEYRG AI +LSME RMTICNMSIEAGARAGM+APD+TT+ Sbjct: 189 DIILALIAKIGTGGGQGHVIEYRGEAIRALSMEARMTICNMSIEAGARAGMIAPDDTTFA 248 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL RPHAP G W+AAL YW+ L TDP AVFD EV LDA LSP+VTWGTNPGQG PL Sbjct: 249 YLEGRPHAPKGRDWEAALEYWRSLPTDPDAVFDEEVLLDAGSLSPYVTWGTNPGQGAPLD 308 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 + VPDP D ER AAE+ALAYMDL+PG +R+I VD VF+GSCTNGRIEDLR A V Sbjct: 309 SVVPDPATFSDPIERAAAERALAYMDLQPGTPLREIRVDTVFIGSCTNGRIEDLRAAASV 368 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 L+GRKVAPGVR+L+VPGSM V+AQAE EGL +F AGAEWR AGCSMCLGMNPDQLAPG Sbjct: 369 LQGRKVAPGVRVLVVPGSMAVKAQAEAEGLDRIFRDAGAEWRNAGCSMCLGMNPDQLAPG 428 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 +R A+TSNRNFEGRQG+GGRTHLVSP VAAATAV G L+AP+DL+ Sbjct: 429 QRSASTSNRNFEGRQGRGGRTHLVSPLVAAATAVAGHLAAPSDLD 473 >tr|C0W2R0|C0W2R0_9ACTO Tax_Id=525246 (leuC)SubName: Full=3-isopropylmalate dehydratase; EC=4.2.1.33;[Actinomyces urogenitalis DSM 15434] Length = 473 Score = 724 bits (1868), Expect = 0.0 Identities = 349/464 (75%), Positives = 390/464 (84%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 +TLAEKVW DHVV G + APDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLT+ATE Sbjct: 3 KTLAEKVWQDHVVSQGADGAPDLLYIDLHLVHEVTSPQAFEGLRLAGRQVRRPDLTLATE 62 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHN PT+DID PIAD SRTQ+ETLRRNCAEFG+RLH +GD +QGIVH VGPQLGLTQPG Sbjct: 63 DHNTPTLDIDLPIADLTSRTQIETLRRNCAEFGVRLHSLGDADQGIVHAVGPQLGLTQPG 122 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 MT+VCGDSHTSTHGAFGALA GIGTS+VEHVLATQTL ++PF+TM+V +DG LPAG Sbjct: 123 MTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLQMKPFQTMSVRIDGELPAGSGAK 182 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GT G QGHVIEYRGSAIE LSME RMTICNMSIEAGARAGM+APD+TT++ Sbjct: 183 DIILAIIAKIGTNGAQGHVIEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDQTTFD 242 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL+ RPHAP G WDAA+ W LRTD AVFDTEV L+A ++ PFVTWGTNPGQG+P+ Sbjct: 243 YLQGRPHAPQGEDWDAAVACWSSLRTDEDAVFDTEVVLEAEDIEPFVTWGTNPGQGLPIS 302 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 ATVPDPE I D+ ER+AAE+AL YMDL PG +R+I VD VF+GSCTNGRIEDLR AEV Sbjct: 303 ATVPDPEQIADETERRAAERALEYMDLRPGTPLREIHVDTVFLGSCTNGRIEDLRAAAEV 362 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 +RGR APGVRML+VP S R+R QAE+EGL +VF GAEWR AGCSMCL MNPD+LAPG Sbjct: 363 VRGRTKAPGVRMLVVPASARIRLQAEEEGLDQVFKDFGAEWRNAGCSMCLAMNPDKLAPG 422 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS PADL Sbjct: 423 ERSASTSNRNFEGRQGKGGRTHLVSPVVAAATAVRGTLSTPADL 466 >tr|A5CQN2|A5CQN2_CLAM3 Tax_Id=443906 (leuC)SubName: Full=LeuC protein; EC=4.2.1.33;[Clavibacter michiganensis subsp. michiganensis] Length = 489 Score = 722 bits (1863), Expect = 0.0 Identities = 350/465 (75%), Positives = 388/465 (83%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 A+TLAEKVW DH+V G + PDL+YIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT Sbjct: 4 AKTLAEKVWADHLVAEGADGTPDLLYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 63 Query: 68 EDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQP 127 EDHN PTV ID+PIAD SRTQ+ TLR+N EFGIRLH +GD+EQGIVHVVGPQLGLT P Sbjct: 64 EDHNTPTVGIDQPIADLTSRTQIHTLRKNAEEFGIRLHSLGDIEQGIVHVVGPQLGLTMP 123 Query: 128 GMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSX 187 G+T+VCGDSHTSTHGAFGA+A GIGTSEVEHV+ATQTLPL+PFKTMAV V+G L GV+ Sbjct: 124 GITVVCGDSHTSTHGAFGAMAFGIGTSEVEHVMATQTLPLQPFKTMAVTVEGTLRPGVTA 183 Query: 188 XXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTY 247 GTGGGQG+V+EYRGSAI SLSMEGRMTICNMSIEAGARAGMVAPD+TTY Sbjct: 184 KDIILAVIAQIGTGGGQGYVLEYRGSAIRSLSMEGRMTICNMSIEAGARAGMVAPDQTTY 243 Query: 248 EYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPL 307 +YL RPHAPTGA WD A+ YW L TD AVFD EV LDA L PFVTWGTNPGQGV L Sbjct: 244 DYLEGRPHAPTGADWDEAVAYWDTLATDDDAVFDAEVFLDADTLEPFVTWGTNPGQGVSL 303 Query: 308 CATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAE 367 VPDP + D ER AAE+ALAYMDL PG M++IAVD VF+GSCTN R+EDLR AE Sbjct: 304 SEPVPDPAAVADPNERAAAERALAYMDLAPGTPMKEIAVDTVFIGSCTNSRVEDLRAAAE 363 Query: 368 VLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAP 427 ++RGR A GVR+++VPGS RVR +AE EG+ +VFT GAEWR AGCSMCLGMNPDQLAP Sbjct: 364 IVRGRTKAEGVRVMVVPGSARVRLEAEAEGIDKVFTDFGAEWRFAGCSMCLGMNPDQLAP 423 Query: 428 GERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 GERCA+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGTLS+P DL Sbjct: 424 GERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSPWDL 468 >sp|A6W7Q7|LEUC_KINRD Tax_Id=266940 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Kineococcus radiotolerans] Length = 477 Score = 721 bits (1860), Expect = 0.0 Identities = 352/468 (75%), Positives = 389/468 (83%), Gaps = 3/468 (0%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 ARTLAEKVWDDHVV G++ PDL+YIDLHLVHEVTSPQAFDGLR AGRPVRR DLTIAT Sbjct: 2 ARTLAEKVWDDHVVRKGQDGEPDLLYIDLHLVHEVTSPQAFDGLRAAGRPVRRLDLTIAT 61 Query: 68 EDHNVPTVDIDKPIA---DPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGL 124 EDHN PTVDID+P++ D S Q++TLR NCAEFG+RLHP+GD EQGIVHVVGPQLGL Sbjct: 62 EDHNTPTVDIDRPLSLLEDKTSAKQLQTLRENCAEFGVRLHPLGDAEQGIVHVVGPQLGL 121 Query: 125 TQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAG 184 TQPGMT+VCGDSHTSTHGAFG+L MGIGTSEVEHVLATQTLPL+PFKTMA+ VDG L G Sbjct: 122 TQPGMTVVCGDSHTSTHGAFGSLGMGIGTSEVEHVLATQTLPLKPFKTMAITVDGTLKPG 181 Query: 185 VSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDE 244 + GTGGGQG+V+EYRG AI +LSMEGRMTICNMSIEAGARAGMVAPDE Sbjct: 182 TTAKDVILAVIAEIGTGGGQGYVLEYRGEAIRNLSMEGRMTICNMSIEAGARAGMVAPDE 241 Query: 245 TTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQG 304 TT+ YL RPHAP GA WDAA+ YW+ LRTD A FD EV LD + L PFVTWGTNPGQG Sbjct: 242 TTFAYLEGRPHAPQGADWDAAVEYWRTLRTDDDAEFDAEVVLDGSALEPFVTWGTNPGQG 301 Query: 305 VPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRV 364 VPL +VP+PE IGDDG RQ E+AL YM LE G MRDIAVD VF+GSCTN RIEDLR Sbjct: 302 VPLSGSVPEPERIGDDGVRQGVERALEYMGLEGGTPMRDIAVDTVFIGSCTNSRIEDLRA 361 Query: 365 VAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQ 424 A+V+RGR+ A VR+++VPGS +VR QAE EG+ VF GA+WR AGCSMCLGMNPDQ Sbjct: 362 AADVVRGRRKADSVRVMVVPGSAKVRLQAEAEGIDTVFKEFGADWRFAGCSMCLGMNPDQ 421 Query: 425 LAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 LAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+PADL Sbjct: 422 LAPGERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 469 >tr|D1BDJ2|D1BDJ2_9MICO Tax_Id=446469 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Sanguibacter keddieii DSM 10542] Length = 479 Score = 714 bits (1844), Expect = 0.0 Identities = 346/465 (74%), Positives = 389/465 (83%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 A TLAEKVWD H+V G + APDL+YIDLHLVHEVTSPQAF+GLRLAGRPVRRPDLTIAT Sbjct: 2 AGTLAEKVWDAHLVRRGSDGAPDLLYIDLHLVHEVTSPQAFEGLRLAGRPVRRPDLTIAT 61 Query: 68 EDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQP 127 EDHN PT++ID PIAD SRTQ++TLR N EFG+R+H +GD +QGIVHVVGPQLGLT P Sbjct: 62 EDHNTPTLNIDLPIADLTSRTQIDTLRNNAKEFGVRIHSLGDADQGIVHVVGPQLGLTMP 121 Query: 128 GMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSX 187 G+T+VCGDSHTSTHGAFGALA GIGTSEVEHVLATQTLPL PFKTMA+ VDG LP G + Sbjct: 122 GLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLAPFKTMAITVDGALPEGSTA 181 Query: 188 XXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTY 247 GTGGGQG+V+EYRG AI SLSMEGRMTICNMSIEAGARAGM+APDETT+ Sbjct: 182 KDIILAVIAKIGTGGGQGYVLEYRGEAIRSLSMEGRMTICNMSIEAGARAGMIAPDETTF 241 Query: 248 EYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPL 307 EYL+ RPHAP GA WDAA+ YW+ LRTD A FDTEV L+AA+L PFVTWGTNPGQG+PL Sbjct: 242 EYLKGRPHAPEGADWDAAVEYWKTLRTDDDATFDTEVVLEAADLEPFVTWGTNPGQGLPL 301 Query: 308 CATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAE 367 A VP P I D+ ER AE+A+ YM L PG +RDIA+D VF+GSCTNGRIEDLR VAE Sbjct: 302 SANVPVPSEIADENERVTAERAIEYMGLNPGTPLRDIAIDTVFIGSCTNGRIEDLRAVAE 361 Query: 368 VLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAP 427 ++ G+K A +R+L+VPGS RVR QAE EGL +VF GAEWR AGCSMCLGMNPDQLAP Sbjct: 362 IVEGKKKADTLRVLVVPGSARVRLQAEAEGLDKVFLDFGAEWRNAGCSMCLGMNPDQLAP 421 Query: 428 GERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 GER A+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGTLS+P+DL Sbjct: 422 GERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSPSDL 466 >sp|B8HAC9|LEUC_ARTCA Tax_Id=452863 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Arthrobacter chlorophenolicus] Length = 484 Score = 711 bits (1834), Expect = 0.0 Identities = 348/470 (74%), Positives = 388/470 (82%), Gaps = 4/470 (0%) Query: 8 ARTLAEKVWDDHVVV----SGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDL 63 A+TLAEKVWD HVV +G N PDL++IDLHLVHEVTSPQAF+GLRLAGRP+RRPDL Sbjct: 2 AKTLAEKVWDAHVVRKGDGAGANAQPDLLFIDLHLVHEVTSPQAFEGLRLAGRPLRRPDL 61 Query: 64 TIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLG 123 TIATEDHN PT+DIDKPIAD SRTQ++TLR NCAEFG+RLH +GD EQGIVHVVGPQLG Sbjct: 62 TIATEDHNTPTLDIDKPIADLTSRTQIQTLRNNCAEFGVRLHSLGDAEQGIVHVVGPQLG 121 Query: 124 LTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPA 183 LTQPGMT+VCGDSHTSTHGAFGALAMGIGTSEVEHV+ATQTL L+PFKTMA+NV+G L Sbjct: 122 LTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLKPFKTMAINVEGTLRP 181 Query: 184 GVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPD 243 GV+ GTGGGQG+V+EYRGSAI +LSM+ RMTICNMSIEAGARAGMVAPD Sbjct: 182 GVTAKDIILAVIAKIGTGGGQGYVLEYRGSAIRALSMDARMTICNMSIEAGARAGMVAPD 241 Query: 244 ETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQ 303 ETTY Y++ RPHAP GA WDAA+ YW L+TD A FD EV LDA L PFVTWGTNPGQ Sbjct: 242 ETTYAYMQGRPHAPEGADWDAAVEYWNTLKTDDDATFDVEVDLDADTLEPFVTWGTNPGQ 301 Query: 304 GVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLR 363 GV L VP PE GD+ + AAE+AL YM LE G M+DI VD VF+GSCTN RIEDLR Sbjct: 302 GVSLSQAVPSPEDFGDENAKAAAERALQYMGLEAGTPMKDIRVDTVFLGSCTNSRIEDLR 361 Query: 364 VVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPD 423 A+++RGR+ P VRML+VPGS RVR +AE EGL VF GAEWR AGCSMCLGMNPD Sbjct: 362 AAADIIRGREKDPKVRMLVVPGSARVRLEAEAEGLDRVFKDFGAEWRFAGCSMCLGMNPD 421 Query: 424 QLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 QL PGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+P+DL+ Sbjct: 422 QLEPGERCASTSNRNFEGRQGKGGRTHLVSPVVAAATAVRGTLSSPSDLD 471 >sp|O86534|LEUC_STRCO Tax_Id=1902 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Streptomyces coelicolor] Length = 476 Score = 710 bits (1833), Expect = 0.0 Identities = 351/465 (75%), Positives = 386/465 (83%), Gaps = 1/465 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 RTLAEKVWDDHVV E PDL++IDLHL+HEVTSPQAFDGLR +GRPVRR DLTIATE Sbjct: 3 RTLAEKVWDDHVVRRAEGE-PDLLFIDLHLLHEVTSPQAFDGLRKSGRPVRRLDLTIATE 61 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHN PT+DIDKPIADPVSR Q+ETLR+NCA+FG+RLHP+GDVEQG+VHVVGPQLGLTQPG Sbjct: 62 DHNTPTLDIDKPIADPVSRAQLETLRKNCADFGVRLHPLGDVEQGVVHVVGPQLGLTQPG 121 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 T+VCGDSHTSTHGAFGALA GIGTS+VEHVLATQTLPL KTMA+ VDG LP GV+ Sbjct: 122 TTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVDGELPEGVTAK 181 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQG+++EYRG AIE LSME RMTICNMSIEAGARAGM+APDETT+ Sbjct: 182 DLILAIIARIGTGGGQGYILEYRGEAIEKLSMEARMTICNMSIEAGARAGMIAPDETTFA 241 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL+ RPHAP GA WDAA+ YW+ LRTD A FD EV ++AAEL+PFVTWGTNPGQG PL Sbjct: 242 YLQGRPHAPEGADWDAAVEYWKTLRTDDDAEFDAEVVIEAAELAPFVTWGTNPGQGAPLS 301 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 A VPDP D ER AAEKAL YM LE G+ +R I VD VFVGSCTNGRIEDLR AE+ Sbjct: 302 AAVPDPASYEDASERFAAEKALEYMGLEAGQPLRSIQVDTVFVGSCTNGRIEDLRAAAEI 361 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 +R RKVA GVRML+VPGS RV QA EGL VF AGAEWR AGCSMCLGMNPDQLAPG Sbjct: 362 VRDRKVADGVRMLVVPGSARVGLQAVSEGLDVVFKEAGAEWRHAGCSMCLGMNPDQLAPG 421 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G L++PADL+ Sbjct: 422 ERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLS 466 >tr|C5CAC8|C5CAC8_MICLC Tax_Id=465515 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Micrococcus luteus] Length = 484 Score = 710 bits (1833), Expect = 0.0 Identities = 351/476 (73%), Positives = 387/476 (81%), Gaps = 4/476 (0%) Query: 1 MALQTREARTLAEKVWDDHVVVSGRNEA----PDLIYIDLHLVHEVTSPQAFDGLRLAGR 56 M T RTLAEKVWD+HVVV G E PDL+YIDLHLVHEVTSPQAF+GLRLAGR Sbjct: 1 MTTATTRPRTLAEKVWDEHVVVRGEGEGASRTPDLLYIDLHLVHEVTSPQAFEGLRLAGR 60 Query: 57 PVRRPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVH 116 PVRRPDLTIATEDHN PT+DID+PIAD SRTQ+ETLR NCAEFG+RLHP+GD EQGIVH Sbjct: 61 PVRRPDLTIATEDHNTPTLDIDQPIADATSRTQIETLRANCAEFGVRLHPLGDAEQGIVH 120 Query: 117 VVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVN 176 VVGPQLGLTQPG+T+VCGDSHTSTHGAFGALA GIGTSEVEHVLATQTLPL+PFKTMAV Sbjct: 121 VVGPQLGLTQPGLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLKPFKTMAVT 180 Query: 177 VDGRLPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGAR 236 VDG L GV+ GTGGGQG V+EYRG AI +LSMEGRMTICNMSIEAGAR Sbjct: 181 VDGTLRPGVTAKDIILAVIAKIGTGGGQGFVLEYRGEAIRNLSMEGRMTICNMSIEAGAR 240 Query: 237 AGMVAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVT 296 AGMVAPDETT+ YL+ RPHAP GA WDAA+ +W+ L TD GA FD EV +DA L PFVT Sbjct: 241 AGMVAPDETTFAYLKGRPHAPVGADWDAAVEHWRTLATDEGAEFDAEVVIDADTLEPFVT 300 Query: 297 WGTNPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTN 356 WGTNPGQGV L VP PE D ++AA KAL+YMDL PG M+ + VD VF+GSCTN Sbjct: 301 WGTNPGQGVSLNDAVPAPEDFADPVAQEAARKALSYMDLAPGTPMKQVEVDTVFMGSCTN 360 Query: 357 GRIEDLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSM 416 RIEDLR AEV+RGR+ A G+R+++VPGS RVR QA EGL VF GAEWR AGCSM Sbjct: 361 SRIEDLRAFAEVVRGRRKAEGLRVMVVPGSARVRLQAMDEGLDRVFEDFGAEWRFAGCSM 420 Query: 417 CLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 CLGMNPDQLAPGERCA+TSNRNFEGRQGKGGRTHLVSP VAAATAV G L++P+DL Sbjct: 421 CLGMNPDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPVVAAATAVLGRLASPSDL 476 >tr|D1AB58|D1AB58_THECU Tax_Id=471852 SubName: Full=3-isopropylmalate dehydratase, large subunit;[Thermomonospora curvata DSM 43183] Length = 465 Score = 710 bits (1832), Expect = 0.0 Identities = 351/464 (75%), Positives = 390/464 (84%), Gaps = 1/464 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 RTLA+KV+D HVV E PDL+YIDLHLVHEVTSPQAFDGLR+AGR VRRPDLTIATE Sbjct: 3 RTLADKVYDAHVVRRAEGE-PDLLYIDLHLVHEVTSPQAFDGLRMAGRKVRRPDLTIATE 61 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHNVPT ++ PIADPVSRTQVETLR+N AEFGIRLHPMGD QGIVHV+GPQLGLTQPG Sbjct: 62 DHNVPTQNLLAPIADPVSRTQVETLRKNAAEFGIRLHPMGDEGQGIVHVIGPQLGLTQPG 121 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 MT+VCGDSHTSTHGAFGALA GIGTSEVEHVLATQTLP K MAV V+G LP GV+ Sbjct: 122 MTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPQIKPKNMAVTVNGTLPVGVTAK 181 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQGH+IEYRG AI LSMEGRMT+CNMSIEAGARAGM+APDETT+ Sbjct: 182 DLILAIIAKIGTGGGQGHIIEYRGEAIRGLSMEGRMTVCNMSIEAGARAGMIAPDETTFA 241 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL+ RPHAP GA+WD A+ YW+ LRTD AVFD EV +DA+ L+P+VTWGTNPGQG+PL Sbjct: 242 YLKGRPHAPKGAEWDKAVEYWKSLRTDDDAVFDKEVVIDASTLTPYVTWGTNPGQGLPLS 301 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 +VPDP D ERQAAE+AL YM L PG +RDI +D VFVGSCTNGRIEDLR VAEV Sbjct: 302 ESVPDPASFEDPIERQAAERALEYMGLTPGTPLRDIKIDTVFVGSCTNGRIEDLRAVAEV 361 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 L+GRKVA GVRMLIVPGSM+V+AQA++EGL E+F AGAEWR+AGCSMCL MNPD+L+PG Sbjct: 362 LKGRKVADGVRMLIVPGSMKVKAQAQEEGLDEIFKAAGAEWREAGCSMCLAMNPDKLSPG 421 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 ER A+TSNRNFEGRQG GGRTHLVSPAVAAATAV G L+APADL Sbjct: 422 ERSASTSNRNFEGRQGPGGRTHLVSPAVAAATAVTGRLTAPADL 465 >tr|C8XEL9|C8XEL9_NAKMY Tax_Id=479431 SubName: Full=3-isopropylmalate dehydratase, large subunit;[Nakamurella multipartita] Length = 486 Score = 709 bits (1831), Expect = 0.0 Identities = 355/475 (74%), Positives = 391/475 (82%), Gaps = 11/475 (2%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 A TLAEKVW+ HVV + E PDL+YIDLHLVHEVTSPQAFDGLR AGRPVRRPDLT+AT Sbjct: 2 ALTLAEKVWNAHVVHAAEGE-PDLLYIDLHLVHEVTSPQAFDGLRQAGRPVRRPDLTLAT 60 Query: 68 EDHNVPT---VDIDKP-------IADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHV 117 EDHNVPT VD D I DPVSRTQVETLR NCAEFG+RL PMGD EQGIVHV Sbjct: 61 EDHNVPTLFQVDADGGTRSRNLLIEDPVSRTQVETLRANCAEFGVRLFPMGDYEQGIVHV 120 Query: 118 VGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNV 177 VGPQLG+TQPGMTIVCGDSHTSTHGAFGALA GIGTSEVEHVLATQTLPL+PFKTMA+ V Sbjct: 121 VGPQLGITQPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLKPFKTMAITV 180 Query: 178 DGRLPAGVSXXXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARA 237 +G L GV+ GTGGGQG+V+EYRG AI +LSMEGRMTICNMSIEAGARA Sbjct: 181 EGTLAPGVTAKDIILAVIAKIGTGGGQGYVLEYRGEAIRALSMEGRMTICNMSIEAGARA 240 Query: 238 GMVAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTW 297 GM+APDETT+ Y++ R HAP G WD A+ YW+ LRTD A FD EV LD + L+PFVTW Sbjct: 241 GMIAPDETTFAYVQGRDHAPKGQDWDRAVEYWRSLRTDDDATFDAEVILDGSALTPFVTW 300 Query: 298 GTNPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNG 357 GTNPGQG+PL VPDPE + DD ER A EKAL+YMDL PG +R I VD VF+GSCTNG Sbjct: 301 GTNPGQGLPLSDVVPDPEAMVDDNERLATEKALSYMDLTPGTPLRQIHVDTVFLGSCTNG 360 Query: 358 RIEDLRVVAEVLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMC 417 RIEDLR A++LRGR++ P +RML+VPGSMRVRAQAE+EGL +VF AGAEWR AGCSMC Sbjct: 361 RIEDLRAAADILRGRRIDPTLRMLVVPGSMRVRAQAEEEGLDQVFLDAGAEWRSAGCSMC 420 Query: 418 LGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 LGMNPDQLAPGER A+TSNRNFEGRQGKGGRTHLVSP VAAATAVRGTLS+PADL Sbjct: 421 LGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADL 475 >tr|C1RN67|C1RN67_9CELL Tax_Id=446466 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Cellulomonas flavigena DSM 20109] Length = 487 Score = 709 bits (1830), Expect = 0.0 Identities = 345/465 (74%), Positives = 389/465 (83%) Query: 8 ARTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIAT 67 A TLAEKVW+ HVV G + APDL+YIDLHLVHEVTSPQAF+GLRLAGR VRRPDLT+AT Sbjct: 2 AGTLAEKVWEAHVVRRGTDGAPDLLYIDLHLVHEVTSPQAFEGLRLAGRQVRRPDLTLAT 61 Query: 68 EDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQP 127 EDHN PT+DID+PIAD SRTQ+ETLR N AEFG+R+H +GD +QGIVH VGPQLGLTQP Sbjct: 62 EDHNTPTLDIDRPIADATSRTQIETLRNNAAEFGVRIHSLGDADQGIVHQVGPQLGLTQP 121 Query: 128 GMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSX 187 G+T+VCGDSHTSTHGAFGALA GIGTSEVEHVLATQTLPL PFKTMA+ V+G+LP G S Sbjct: 122 GLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLAPFKTMAITVNGQLPIGASA 181 Query: 188 XXXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTY 247 GTGGGQG+V+EYRG AI +LSMEGRMTICNMSIEAGARAGM+APDETT+ Sbjct: 182 KDIILAIIARIGTGGGQGYVLEYRGEAIRNLSMEGRMTICNMSIEAGARAGMIAPDETTF 241 Query: 248 EYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPL 307 EYL+ RPHAP GA WDAA+ YW+ LRTD AVFD EV L+AA+L PFVTWGTNPGQG+PL Sbjct: 242 EYLKGRPHAPEGADWDAAVEYWRTLRTDDDAVFDAEVVLEAADLEPFVTWGTNPGQGLPL 301 Query: 308 CATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAE 367 VP PE I D ER AAE+A+ YM L PG+ +RDI VD VF+GSCTNGRIEDLR VA+ Sbjct: 302 SGNVPVPEEIADANERVAAERAIEYMGLTPGQPLRDIKVDTVFIGSCTNGRIEDLRAVAK 361 Query: 368 VLRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAP 427 +++GRK A VR+L+VP S RVR QAE EGL ++F GAEWR AGCSMCLGMNPDQLAP Sbjct: 362 LVKGRKKADDVRVLVVPASARVRLQAEAEGLDQIFLDFGAEWRNAGCSMCLGMNPDQLAP 421 Query: 428 GERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATA+RGTLS+ ADL Sbjct: 422 QERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAIRGTLSSVADL 466 >sp|B1VZ03|LEUC_STRGG Tax_Id=455632 (leuC)RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Isopropylmalate isomerase; AltName: Full=Alpha-IPM isomerase; Short=IPMI;[Streptomyces griseus subsp. griseus] Length = 475 Score = 709 bits (1829), Expect = 0.0 Identities = 353/465 (75%), Positives = 387/465 (83%), Gaps = 1/465 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 RTLAEKVWDDHVV E PDL++IDLHL+HEVTSPQAFDGLR AGRPVRR DLTIATE Sbjct: 3 RTLAEKVWDDHVVRRAEGE-PDLLFIDLHLLHEVTSPQAFDGLRQAGRPVRRLDLTIATE 61 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHN PT+DIDKPIADPVSR Q+ETLR+NCA+FG+RLHP+GDVEQG+VHVVGPQLGLTQPG Sbjct: 62 DHNTPTLDIDKPIADPVSRAQLETLRKNCADFGVRLHPLGDVEQGVVHVVGPQLGLTQPG 121 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 T+VCGDSHTSTHGAFGALA GIGTS+VEHVLATQTLPL KTMA+ V+G LP V+ Sbjct: 122 TTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVEGELPDEVTAK 181 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQG+++EYRGSAIE LSME RMTICNMSIEAGARAGM+APD TT++ Sbjct: 182 DLILAIIARIGTGGGQGYILEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDATTFD 241 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL R HAP G WDAA+ YW+ LR+D AVFD EV +DAAEL+PFVTWGTNPGQG PL Sbjct: 242 YLEGRDHAPRGEDWDAAVAYWKTLRSDDDAVFDAEVVIDAAELAPFVTWGTNPGQGAPLS 301 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 A VPDP D ER AAEKAL YM L G+A+RDI VD VFVGSCTNGRIEDLR A V Sbjct: 302 ANVPDPASYEDASERFAAEKALEYMGLTAGQALRDINVDTVFVGSCTNGRIEDLRNAAAV 361 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 L GRKVA GVRMLIVPGS+RV QA EGL +VFT AGAEWR AGCSMCLGMNPDQLAPG Sbjct: 362 LDGRKVADGVRMLIVPGSVRVALQAVAEGLDKVFTEAGAEWRHAGCSMCLGMNPDQLAPG 421 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G L++PADL+ Sbjct: 422 ERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLS 466 >tr|C9N9V0|C9N9V0_9ACTO Tax_Id=591167 SubName: Full=3-isopropylmalate dehydratase, large subunit; EC=4.2.1.33;[Streptomyces flavogriseus ATCC 33331] Length = 474 Score = 709 bits (1829), Expect = 0.0 Identities = 350/465 (75%), Positives = 386/465 (83%), Gaps = 1/465 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 RTLAEKVWDDHVV E PDL++IDLHL+HEVTSPQAFDGLR AGRPVRR DLTIATE Sbjct: 3 RTLAEKVWDDHVVRRADGE-PDLLFIDLHLLHEVTSPQAFDGLRQAGRPVRRLDLTIATE 61 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHN PT+DIDKPIADPVSR Q+ETLR+NCAEFG+RLHP+GDVEQG+VHVVGPQLGLTQPG Sbjct: 62 DHNTPTLDIDKPIADPVSRAQLETLRKNCAEFGVRLHPLGDVEQGVVHVVGPQLGLTQPG 121 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 T+VCGDSHTSTHGAFGALA GIGTS+VEHVLATQTLPL +TMA+ V+G LP V+ Sbjct: 122 TTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVEGELPDSVTAK 181 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQG+++EYRGSAIE LSME RMTICNMSIEAGARAGM+APDETT+ Sbjct: 182 DLILAIIARIGTGGGQGYILEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDETTFA 241 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL+ R HAP G WDAA+ YW+ LRTD AVFD EV +D A L+PFVTWGTNPGQG PL Sbjct: 242 YLKGRDHAPEGKDWDAAVEYWKTLRTDDDAVFDAEVVIDGASLAPFVTWGTNPGQGAPLS 301 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 A VPDP D ER AAEKAL YM L G+ +R+I VD VFVGSCTNGRIEDLR A V Sbjct: 302 ANVPDPASYEDASERHAAEKALEYMGLTAGQPLREIGVDTVFVGSCTNGRIEDLRNAASV 361 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 L GRKVA GVRML+VPGS+RV QA +EGL +VFT AGAEWR AGCSMCLGMNPDQLAPG Sbjct: 362 LEGRKVADGVRMLVVPGSVRVALQAVEEGLDKVFTAAGAEWRHAGCSMCLGMNPDQLAPG 421 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN 473 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G L++PADL+ Sbjct: 422 ERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLS 466 >tr|B5H064|B5H064_STRCL Tax_Id=443255 SubName: Full=3-isopropylmalate dehydratase large subunit;[Streptomyces clavuligerus ATCC 27064] Length = 475 Score = 709 bits (1829), Expect = 0.0 Identities = 350/464 (75%), Positives = 387/464 (83%), Gaps = 1/464 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 RTLAEKVWDDHVV E PDL+YIDLHL+HEVTSPQAFDGLR++GR VRR DLTIATE Sbjct: 3 RTLAEKVWDDHVVRRAEGE-PDLLYIDLHLLHEVTSPQAFDGLRMSGRTVRRLDLTIATE 61 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHN PT+DIDKPIADPVSR Q+ETLR+NCAEFG+RLHP+GDVEQG+VHVVGPQLGLTQPG Sbjct: 62 DHNTPTLDIDKPIADPVSRAQLETLRKNCAEFGVRLHPLGDVEQGVVHVVGPQLGLTQPG 121 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 T+VCGDSHTSTHGAFGALA GIGTS+VEHVLATQTLPL +TMA+ V+G LP GV+ Sbjct: 122 TTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVEGELPDGVTAK 181 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQG+++EYRG AIE LSME RMTICNMSIEAGARAGM+APDETT+ Sbjct: 182 DLILAIIARIGTGGGQGYILEYRGPAIEKLSMESRMTICNMSIEAGARAGMIAPDETTFA 241 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL++R HAP +WDAA+ YW+ LR+D AVFD EV +DAA LSPFVTWGTNPGQG PL Sbjct: 242 YLKDRDHAPRDEEWDAAVAYWKTLRSDDDAVFDAEVVIDAAALSPFVTWGTNPGQGAPLS 301 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 A+VPDP D ER AAEKAL YM L G+ +RDI VD VFVGSCTNGRIEDLR A V Sbjct: 302 ASVPDPASYEDASERLAAEKALEYMGLAAGQPLRDITVDTVFVGSCTNGRIEDLRSAATV 361 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 L GRKVA GVRML+VPGS+RV QA EGL +VFT AGAEWR AGCSMCLGMNPDQLAPG Sbjct: 362 LEGRKVADGVRMLVVPGSVRVSLQAVAEGLDKVFTAAGAEWRHAGCSMCLGMNPDQLAPG 421 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G L++PADL Sbjct: 422 ERSASTSNRNFEGRQGKGGRTHLVSPPVAAATAVLGHLASPADL 465 >tr|A7DWG1|A7DWG1_STRCL Tax_Id=1901 (leuC)SubName: Full=Putative isopropylmalate isomerase large subunit;[Streptomyces clavuligerus] Length = 483 Score = 709 bits (1829), Expect = 0.0 Identities = 350/464 (75%), Positives = 387/464 (83%), Gaps = 1/464 (0%) Query: 9 RTLAEKVWDDHVVVSGRNEAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATE 68 RTLAEKVWDDHVV E PDL+YIDLHL+HEVTSPQAFDGLR++GR VRR DLTIATE Sbjct: 11 RTLAEKVWDDHVVRRAEGE-PDLLYIDLHLLHEVTSPQAFDGLRMSGRTVRRLDLTIATE 69 Query: 69 DHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPG 128 DHN PT+DIDKPIADPVSR Q+ETLR+NCAEFG+RLHP+GDVEQG+VHVVGPQLGLTQPG Sbjct: 70 DHNTPTLDIDKPIADPVSRAQLETLRKNCAEFGVRLHPLGDVEQGVVHVVGPQLGLTQPG 129 Query: 129 MTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSXX 188 T+VCGDSHTSTHGAFGALA GIGTS+VEHVLATQTLPL +TMA+ V+G LP GV+ Sbjct: 130 TTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVEGELPDGVTAK 189 Query: 189 XXXXXXXXXXGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYE 248 GTGGGQG+++EYRG AIE LSME RMTICNMSIEAGARAGM+APDETT+ Sbjct: 190 DLILAIIARIGTGGGQGYILEYRGPAIEKLSMESRMTICNMSIEAGARAGMIAPDETTFA 249 Query: 249 YLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDAAELSPFVTWGTNPGQGVPLC 308 YL++R HAP +WDAA+ YW+ LR+D AVFD EV +DAA LSPFVTWGTNPGQG PL Sbjct: 250 YLKDRDHAPRDEEWDAAVAYWKTLRSDDDAVFDAEVVIDAAALSPFVTWGTNPGQGAPLS 309 Query: 309 ATVPDPELIGDDGERQAAEKALAYMDLEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEV 368 A+VPDP D ER AAEKAL YM L G+ +RDI VD VFVGSCTNGRIEDLR A V Sbjct: 310 ASVPDPASYEDASERLAAEKALEYMGLAAGQPLRDITVDTVFVGSCTNGRIEDLRSAATV 369 Query: 369 LRGRKVAPGVRMLIVPGSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPG 428 L GRKVA GVRML+VPGS+RV QA EGL +VFT AGAEWR AGCSMCLGMNPDQLAPG Sbjct: 370 LEGRKVADGVRMLVVPGSVRVSLQAVAEGLDKVFTAAGAEWRHAGCSMCLGMNPDQLAPG 429 Query: 429 ERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADL 472 ER A+TSNRNFEGRQGKGGRTHLVSP VAAATAV G L++PADL Sbjct: 430 ERSASTSNRNFEGRQGKGGRTHLVSPPVAAATAVLGHLASPADL 473 Database: Amellifera_nr Posted date: Feb 5, 2010 5:10 AM Number of letters in database: 3,846,993,858 Number of sequences in database: 11,275,203 Lambda K H 0.318 0.135 0.406 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11275203 Number of Hits to DB: 3,647,615,090 Number of extensions: 158887189 Number of successful extensions: 329681 Number of sequences better than 10.0: 4767 Number of HSP's gapped: 321863 Number of HSP's successfully gapped: 5503 Length of query: 473 Length of database: 3,846,993,858 Length adjustment: 141 Effective length of query: 332 Effective length of database: 2,257,190,235 Effective search space: 749387158020 Effective search space used: 749387158020 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 82 (36.2 bits)