BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= MMAR_1957
         (165 letters)

Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr;
Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr;
trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr;
Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr;
Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr;
Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr;
Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr;
Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr;
Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr;
Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr;
Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr;
Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 
           11,275,203 sequences; 3,846,993,858 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits)  Value

tr|B2HKY6|B2HKY6_MYCMM Tax_Id=216594 (dfrA)SubName: Full=Dihydro...   305   8e-82
tr|A0PQG8|A0PQG8_MYCUA Tax_Id=362242 (dfrA)SubName: Full=Dihydro...   305   8e-82
sp|Q9CBW1|DYR_MYCLE Tax_Id=1769 (folA)RecName: Full=Dihydrofolat...   223   4e-57
tr|B8ZRR6|B8ZRR6_MYCLB Tax_Id=561304 (folA)SubName: Full=Dihydro...   223   4e-57
tr|C6DLE4|C6DLE4_MYCTK Tax_Id=478434 SubName: Full=Dihydrofolate...   222   1e-56
tr|A4KK37|A4KK37_MYCTU Tax_Id=395095 SubName: Full=Dihydrofolate...   222   1e-56
tr|A2VL99|A2VL99_MYCTU Tax_Id=348776 SubName: Full=Dihydrofolate...   220   3e-56
sp|P0A546|DYR_MYCTU Tax_Id=1773 (folA)RecName: Full=Dihydrofolat...   218   1e-55
sp|P0A547|DYR_MYCBO Tax_Id=1765 (folA)RecName: Full=Dihydrofolat...   218   1e-55
tr|C1AFM6|C1AFM6_MYCBT Tax_Id=561275 (dfrA)SubName: Full=Putativ...   218   1e-55
tr|A5U6B6|A5U6B6_MYCTA Tax_Id=419947 (dfrA)SubName: Full=Dihydro...   218   1e-55
tr|A1KMA5|A1KMA5_MYCBP Tax_Id=410289 (dfrA)SubName: Full=Probabl...   218   1e-55
tr|A5WR14|A5WR14_MYCTF Tax_Id=336982 SubName: Full=Dihydrofolate...   218   1e-55
tr|Q73VZ3|Q73VZ3_MYCPA Tax_Id=1770 (dfrA)SubName: Full=DfrA;[Myc...   216   8e-55
tr|O30463|O30463_MYCAV Tax_Id=1764 (folA)SubName: Full=Dihydrofo...   215   1e-54
tr|A0QIU0|A0QIU0_MYCA1 Tax_Id=243243 (folA)SubName: Full=Dihydro...   214   2e-54
tr|A4TCI8|A4TCI8_MYCGI Tax_Id=350054 SubName: Full=Dihydrofolate...   206   9e-52
tr|A3PYA9|A3PYA9_MYCSJ Tax_Id=164757 SubName: Full=Dihydrofolate...   204   3e-51
tr|Q1BA63|Q1BA63_MYCSS Tax_Id=164756 SubName: Full=Dihydrofolate...   203   4e-51
tr|A1UEU9|A1UEU9_MYCSK Tax_Id=189918 SubName: Full=Dihydrofolate...   203   4e-51
tr|A1T7P5|A1T7P5_MYCVP Tax_Id=350058 SubName: Full=Dihydrofolate...   194   2e-48
tr|A0QVS0|A0QVS0_MYCS2 Tax_Id=246196 (folA)SubName: Full=Dihydro...   191   2e-47
tr|B1MD46|B1MD46_MYCA9 Tax_Id=561007 SubName: Full=Dihydrofolate...   168   2e-40
tr|C4EMW1|C4EMW1_STRRS Tax_Id=479432 SubName: Full=Dihydrofolate...   154   3e-36
tr|C5BYZ5|C5BYZ5_BEUC1 Tax_Id=471853 SubName: Full=Dihydrofolate...   150   3e-35
tr|Q6AFI1|Q6AFI1_LEIXX Tax_Id=59736 (folA)SubName: Full=Dihydrof...   150   4e-35
tr|C1B0L0|C1B0L0_RHOOB Tax_Id=632772 (folA)SubName: Full=Dihydro...   149   1e-34
tr|B9MG01|B9MG01_DIAST Tax_Id=535289 SubName: Full=Dihydrofolate...   149   1e-34
tr|A1W5A2|A1W5A2_ACISJ Tax_Id=232721 SubName: Full=Dihydrofolate...   149   1e-34
tr|Q0SEI0|Q0SEI0_RHOSR Tax_Id=101510 SubName: Full=Dihydrofolate...   147   3e-34
tr|C3JX49|C3JX49_RHOER Tax_Id=596309 (folA)SubName: Full=Dihydro...   146   6e-34
tr|Q5YPL6|Q5YPL6_NOCFA Tax_Id=37329 (dfrA)SubName: Full=Putative...   145   2e-33
tr|A1VQZ7|A1VQZ7_POLNA Tax_Id=365044 SubName: Full=Dihydrofolate...   145   2e-33
tr|A1TM51|A1TM51_ACIAC Tax_Id=397945 SubName: Full=Dihydrofolate...   144   4e-33
tr|C9Y9Z4|C9Y9Z4_9BURK Tax_Id=667019 (folA)SubName: Full=Dihydro...   143   7e-33
tr|A0JZC8|A0JZC8_ARTS2 Tax_Id=290399 SubName: Full=Dihydrofolate...   142   9e-33
tr|Q21U57|Q21U57_RHOFD Tax_Id=338969 SubName: Full=Dihydrofolate...   142   1e-32
tr|C0ZMB2|C0ZMB2_RHOE4 Tax_Id=234621 (folA)SubName: Full=Dihydro...   142   1e-32
tr|C1RGA1|C1RGA1_9CELL Tax_Id=446466 SubName: Full=Dihydrofolate...   142   2e-32
tr|A6WGF8|A6WGF8_KINRD Tax_Id=266940 SubName: Full=Dihydrofolate...   141   2e-32
tr|C1UIQ8|C1UIQ8_9ACTO Tax_Id=526225 SubName: Full=Dihydrofolate...   141   2e-32
tr|A1WMP6|A1WMP6_VEREI Tax_Id=391735 SubName: Full=Dihydrofolate...   141   3e-32
tr|A4AHI2|A4AHI2_9ACTN Tax_Id=312284 SubName: Full=Dihydrofolate...   139   8e-32
tr|Q12CI7|Q12CI7_POLSJ Tax_Id=296591 SubName: Full=Dihydrofolate...   139   1e-31
tr|D1BJ51|D1BJ51_9MICO Tax_Id=446469 SubName: Full=Dihydrofolate...   139   1e-31
tr|A9BMQ5|A9BMQ5_DELAS Tax_Id=398578 SubName: Full=Dihydrofolate...   138   2e-31
tr|C2AP27|C2AP27_TSUPA Tax_Id=521096 SubName: Full=Dihydrofolate...   137   3e-31
tr|C5CTW3|C5CTW3_VARPS Tax_Id=543728 SubName: Full=Dihydrofolate...   137   5e-31
tr|A1R8Y8|A1R8Y8_ARTAT Tax_Id=290340 (folA)SubName: Full=Dihydro...   136   7e-31
tr|C5T5W4|C5T5W4_ACIDE Tax_Id=573060 SubName: Full=Dihydrofolate...   135   1e-30

>tr|B2HKY6|B2HKY6_MYCMM Tax_Id=216594 (dfrA)SubName:
           Full=Dihydrofolate reductase DfrA;[Mycobacterium
           marinum]
          Length = 165

 Score =  305 bits (782), Expect = 8e-82
 Identities = 150/165 (90%), Positives = 150/165 (90%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP
Sbjct: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRC    
Sbjct: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCEVTE 120

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRRL 165
                      ALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRRL
Sbjct: 121 VDVDLPPEDEDALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRRL 165


>tr|A0PQG8|A0PQG8_MYCUA Tax_Id=362242 (dfrA)SubName:
           Full=Dihydrofolate reductase DfrA;[Mycobacterium
           ulcerans]
          Length = 165

 Score =  305 bits (782), Expect = 8e-82
 Identities = 150/165 (90%), Positives = 150/165 (90%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP
Sbjct: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRC    
Sbjct: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCEVTE 120

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRRL 165
                      ALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRRL
Sbjct: 121 VDVDLPPEDEDALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRRL 165


>sp|Q9CBW1|DYR_MYCLE Tax_Id=1769 (folA)RecName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium leprae]
          Length = 165

 Score =  223 bits (569), Expect = 4e-57
 Identities = 107/164 (65%), Positives = 121/164 (73%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MT VGLIWAQST+GVIGRDGG+PWR+PEDL  FK+LTMGH VVMGRRTWDSLP   RPLP
Sbjct: 1   MTVVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRN+V++RQ   +A GA+V GSLE+ +   E + E WVIGG QIY LALPLA RC    
Sbjct: 61  GRRNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTE 120

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                       LAPVLD TW G +GEWLVS SGLRYR+HSY R
Sbjct: 121 VDTYLLHEDDDVLAPVLDDTWVGVTGEWLVSCSGLRYRLHSYHR 164


>tr|B8ZRR6|B8ZRR6_MYCLB Tax_Id=561304 (folA)SubName:
           Full=Dihydrofolate reductase;[Mycobacterium leprae]
          Length = 165

 Score =  223 bits (569), Expect = 4e-57
 Identities = 107/164 (65%), Positives = 121/164 (73%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MT VGLIWAQST+GVIGRDGG+PWR+PEDL  FK+LTMGH VVMGRRTWDSLP   RPLP
Sbjct: 1   MTVVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRN+V++RQ   +A GA+V GSLE+ +   E + E WVIGG QIY LALPLA RC    
Sbjct: 61  GRRNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTE 120

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                       LAPVLD TW G +GEWLVS SGLRYR+HSY R
Sbjct: 121 VDTYLLHEDDDVLAPVLDDTWVGVTGEWLVSCSGLRYRLHSYHR 164


>tr|C6DLE4|C6DLE4_MYCTK Tax_Id=478434 SubName: Full=Dihydrofolate
           reductase dfrA;[Mycobacterium tuberculosis]
          Length = 161

 Score =  222 bits (565), Expect = 1e-56
 Identities = 109/164 (66%), Positives = 123/164 (75%), Gaps = 4/164 (2%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MT VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLP
Sbjct: 1   MTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRNVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC    
Sbjct: 61  GRRNVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTE 116

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 117 VDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 160


>tr|A4KK37|A4KK37_MYCTU Tax_Id=395095 SubName: Full=Dihydrofolate
           reductase dfrA (Tetrahydrofolate
           dehydrogenase);[Mycobacterium tuberculosis str. Haarlem]
          Length = 161

 Score =  222 bits (565), Expect = 1e-56
 Identities = 109/164 (66%), Positives = 123/164 (75%), Gaps = 4/164 (2%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MT VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLP
Sbjct: 1   MTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRNVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC    
Sbjct: 61  GRRNVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTE 116

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 117 VDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 160


>tr|A2VL99|A2VL99_MYCTU Tax_Id=348776 SubName: Full=Dihydrofolate
           reductase dfrA (Tetrahydrofolate
           dehydrogenase);[Mycobacterium tuberculosis C]
          Length = 164

 Score =  220 bits (561), Expect = 3e-56
 Identities = 108/164 (65%), Positives = 123/164 (75%), Gaps = 4/164 (2%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           +T VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLP
Sbjct: 4   VTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLP 63

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRNVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC    
Sbjct: 64  GRRNVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTE 119

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 120 VDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 163


>sp|P0A546|DYR_MYCTU Tax_Id=1773 (folA)RecName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium tuberculosis]
          Length = 159

 Score =  218 bits (556), Expect = 1e-55
 Identities = 107/161 (66%), Positives = 121/161 (75%), Gaps = 4/161 (2%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLPGRR
Sbjct: 2   VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC       
Sbjct: 62  NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158


>sp|P0A547|DYR_MYCBO Tax_Id=1765 (folA)RecName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium bovis]
          Length = 159

 Score =  218 bits (556), Expect = 1e-55
 Identities = 107/161 (66%), Positives = 121/161 (75%), Gaps = 4/161 (2%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLPGRR
Sbjct: 2   VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC       
Sbjct: 62  NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158


>tr|C1AFM6|C1AFM6_MYCBT Tax_Id=561275 (dfrA)SubName: Full=Putative
           dihydrofolate reductase; EC=1.5.1.3;[Mycobacterium
           bovis]
          Length = 159

 Score =  218 bits (556), Expect = 1e-55
 Identities = 107/161 (66%), Positives = 121/161 (75%), Gaps = 4/161 (2%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLPGRR
Sbjct: 2   VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC       
Sbjct: 62  NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158


>tr|A5U6B6|A5U6B6_MYCTA Tax_Id=419947 (dfrA)SubName:
           Full=Dihydrofolate reductase;[Mycobacterium
           tuberculosis]
          Length = 159

 Score =  218 bits (556), Expect = 1e-55
 Identities = 107/161 (66%), Positives = 121/161 (75%), Gaps = 4/161 (2%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLPGRR
Sbjct: 2   VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC       
Sbjct: 62  NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158


>tr|A1KMA5|A1KMA5_MYCBP Tax_Id=410289 (dfrA)SubName: Full=Probable
           dihydrofolate reductase dfrA; EC=1.5.1.3;[Mycobacterium
           bovis]
          Length = 159

 Score =  218 bits (556), Expect = 1e-55
 Identities = 107/161 (66%), Positives = 121/161 (75%), Gaps = 4/161 (2%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLPGRR
Sbjct: 2   VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC       
Sbjct: 62  NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158


>tr|A5WR14|A5WR14_MYCTF Tax_Id=336982 SubName: Full=Dihydrofolate
           reductase dfrA (Tetrahydrofolate
           dehydrogenase);[Mycobacterium tuberculosis]
          Length = 159

 Score =  218 bits (556), Expect = 1e-55
 Identities = 107/161 (66%), Positives = 121/161 (75%), Gaps = 4/161 (2%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA  RPLPGRR
Sbjct: 2   VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVV++RQ   +A GA+VVGSLE+AL       ETWVIGG Q+YALALP A RC       
Sbjct: 62  NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAPVLD+TW G +GEW  SRSGLRYR++SY R
Sbjct: 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158


>tr|Q73VZ3|Q73VZ3_MYCPA Tax_Id=1770 (dfrA)SubName:
           Full=DfrA;[Mycobacterium paratuberculosis]
          Length = 181

 Score =  216 bits (549), Expect = 8e-55
 Identities = 106/161 (65%), Positives = 116/161 (72%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGL+WAQSTSGVIGR G IPW +PEDL  FK +TMGHTV+MGRRTW+SLPA  RPLPGRR
Sbjct: 6   VGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 65

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVVV+R+   VA GA+V GSLE AL  A  D   WVIGGAQIY LALP A RC       
Sbjct: 66  NVVVSRRPDFVAEGARVAGSLEAALAHAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 125

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAP LD +W G +GEWL SRSGLRYR HSYRR
Sbjct: 126 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 166


>tr|O30463|O30463_MYCAV Tax_Id=1764 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Mycobacterium
           avium]
          Length = 181

 Score =  215 bits (548), Expect = 1e-54
 Identities = 106/161 (65%), Positives = 116/161 (72%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGL+WAQSTSGVIGR G IPW +PEDL  FK +TMGHTV+MGRRTW+SLPA  RPLPGRR
Sbjct: 6   VGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 65

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVVV+R+   VA GA+V GSLE AL  A  D   WVIGGAQIY LALP A RC       
Sbjct: 66  NVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 125

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAP LD +W G +GEWL SRSGLRYR HSYRR
Sbjct: 126 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 166


>tr|A0QIU0|A0QIU0_MYCA1 Tax_Id=243243 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Mycobacterium
           avium]
          Length = 176

 Score =  214 bits (546), Expect = 2e-54
 Identities = 105/161 (65%), Positives = 116/161 (72%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           +GL+WAQSTSGVIGR G IPW +PEDL  FK +TMGHTV+MGRRTW+SLPA  RPLPGRR
Sbjct: 1   MGLVWAQSTSGVIGRGGDIPWNVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 60

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVVV+R+   VA GA+V GSLE AL  A  D   WVIGGAQIY LALP A RC       
Sbjct: 61  NVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 120

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   ALAP LD +W G +GEWL SRSGLRYR HSYRR
Sbjct: 121 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 161


>tr|A4TCI8|A4TCI8_MYCGI Tax_Id=350054 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium gilvum]
          Length = 160

 Score =  206 bits (523), Expect = 9e-52
 Identities = 101/164 (61%), Positives = 117/164 (71%), Gaps = 5/164 (3%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MT + LIWAQS+SGVIGRDGGIPW +PED+A FK LTMGHTV+MGR+TW+SLP   RPLP
Sbjct: 1   MTELNLIWAQSSSGVIGRDGGIPWHVPEDMARFKELTMGHTVIMGRQTWESLPEKFRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRNVV+TRQ   VA GA+VV +LE A     P  + WVIGG+Q+Y LALPLA RC    
Sbjct: 61  GRRNVVLTRQADYVAEGAEVVTALEDA-----PLDDAWVIGGSQVYGLALPLATRCEITE 115

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      ALAP+LD+ W GT GEW  S SGLRYR +SY R
Sbjct: 116 VDLDLHRQDEDALAPLLDEAWVGTEGEWRDSASGLRYRFYSYVR 159


>tr|A3PYA9|A3PYA9_MYCSJ Tax_Id=164757 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium sp.]
          Length = 161

 Score =  204 bits (518), Expect = 3e-51
 Identities = 102/164 (62%), Positives = 117/164 (71%), Gaps = 4/164 (2%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           M +VGLIWAQSTSGVIGRDGGIPW LPEDLA FK +T+GH VVMGR TW+SLP   RPLP
Sbjct: 1   MMTVGLIWAQSTSGVIGRDGGIPWHLPEDLARFKEITLGHPVVMGRLTWESLPPKVRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GR+NVV+TRQ   +A GA+VV SL+ AL     D ETWVIGG +IY LAL  A RC    
Sbjct: 61  GRKNVVLTRQADYMAEGAEVVTSLDDAL----GDEETWVIGGERIYTLALGRATRCEVTE 116

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      A+APVL + W GT+G+WL S SGLRYR HSY+R
Sbjct: 117 VEIELHRQDADAVAPVLGEAWVGTAGDWLTSVSGLRYRFHSYQR 160


>tr|Q1BA63|Q1BA63_MYCSS Tax_Id=164756 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium sp.]
          Length = 167

 Score =  203 bits (517), Expect = 4e-51
 Identities = 101/164 (61%), Positives = 117/164 (71%), Gaps = 4/164 (2%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           M +VGLIWAQSTSGVIGRDGGIPW LPEDLA FK +T+GH VVMGR TW+SLP   RPLP
Sbjct: 7   MMTVGLIWAQSTSGVIGRDGGIPWHLPEDLARFKEITLGHPVVMGRLTWESLPPKVRPLP 66

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GR+NVV+TRQ   +A GA+VV SL+ AL     D ETWVIGG ++Y LAL  A RC    
Sbjct: 67  GRKNVVLTRQADYMAEGAEVVTSLDDAL----GDEETWVIGGERVYTLALGRATRCEVTE 122

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      A+APVL + W GT+G+WL S SGLRYR HSY+R
Sbjct: 123 VEIELHRQDADAVAPVLGEAWVGTAGDWLTSVSGLRYRFHSYQR 166


>tr|A1UEU9|A1UEU9_MYCSK Tax_Id=189918 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium sp.]
          Length = 161

 Score =  203 bits (517), Expect = 4e-51
 Identities = 101/164 (61%), Positives = 117/164 (71%), Gaps = 4/164 (2%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           M +VGLIWAQSTSGVIGRDGGIPW LPEDLA FK +T+GH VVMGR TW+SLP   RPLP
Sbjct: 1   MMTVGLIWAQSTSGVIGRDGGIPWHLPEDLARFKEITLGHPVVMGRLTWESLPPKVRPLP 60

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GR+NVV+TRQ   +A GA+VV SL+ AL     D ETWVIGG ++Y LAL  A RC    
Sbjct: 61  GRKNVVLTRQADYMAEGAEVVTSLDDAL----GDEETWVIGGERVYTLALGRATRCEVTE 116

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      A+APVL + W GT+G+WL S SGLRYR HSY+R
Sbjct: 117 VEIELHRQDADAVAPVLGEAWVGTAGDWLTSVSGLRYRFHSYQR 160


>tr|A1T7P5|A1T7P5_MYCVP Tax_Id=350058 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Mycobacterium vanbaalenii]
          Length = 162

 Score =  194 bits (494), Expect = 2e-48
 Identities = 96/164 (58%), Positives = 113/164 (68%), Gaps = 5/164 (3%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           ++ + ++WAQS+SGVIGR   IPW +PED+A FK LTMGHTV+MGR TW+SLPA  RPLP
Sbjct: 3   LSELNMVWAQSSSGVIGRGDAIPWHVPEDMARFKELTMGHTVIMGRLTWESLPAKFRPLP 62

Query: 61  GRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXX 120
           GRRNVVVTRQ G  A GA+VV S E A     P  + WVIGG+QIY LALPLA RC    
Sbjct: 63  GRRNVVVTRQAGYQADGAEVVTSFEDA-----PLDDAWVIGGSQIYGLALPLATRCEITE 117

Query: 121 XXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      ALAPVLD+ W GT G+W  S SGLRYR +S+ R
Sbjct: 118 VDIDLRREDDDALAPVLDEAWVGTEGDWRDSSSGLRYRFYSFVR 161


>tr|A0QVS0|A0QVS0_MYCS2 Tax_Id=246196 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Mycobacterium
           smegmatis]
          Length = 154

 Score =  191 bits (485), Expect = 2e-47
 Identities = 99/159 (62%), Positives = 110/159 (69%), Gaps = 7/159 (4%)

Query: 6   LIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRRNV 65
           LIWAQSTSG+IGRD  IPWRLPEDLA FK +TMGH VVMGR TW+SLPA+ RPLPGRRN+
Sbjct: 3   LIWAQSTSGIIGRDNSIPWRLPEDLARFKEMTMGHPVVMGRLTWESLPASVRPLPGRRNI 62

Query: 66  VVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXXXX 125
           VVTR     A GA+VV  L     P EPDA  WVIGGAQIYA+AL  A+RC         
Sbjct: 63  VVTRDADYRAEGAEVVTDL-----PDEPDA--WVIGGAQIYAMALARADRCEVTEVDIAL 115

Query: 126 XXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                 A APVLD +W  T+GEW  S SGLR+R  SYRR
Sbjct: 116 TPLDGDARAPVLDDSWVATTGEWQTSTSGLRFRFCSYRR 154


>tr|B1MD46|B1MD46_MYCA9 Tax_Id=561007 SubName: Full=Dihydrofolate
           reductase DfrA;[Mycobacterium abscessus]
          Length = 163

 Score =  168 bits (426), Expect = 2e-40
 Identities = 86/163 (52%), Positives = 104/163 (63%), Gaps = 5/163 (3%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           ++GLIWAQ+ +GVIG DG IPWRLPED A FKR+TMGHTV+MGR+TW+SLP + RPLPGR
Sbjct: 4   TIGLIWAQTRAGVIGADGAIPWRLPEDQARFKRITMGHTVIMGRKTWESLPGSVRPLPGR 63

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXX 122
            N+V+TR       GA  VG  + AL  A  D   WVIGG +IY L LPLA RC      
Sbjct: 64  PNIVLTRDALFEPDGALAVGCADAAL--AASDEAPWVIGGGEIYRLFLPLAQRC---EVT 118

Query: 123 XXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRRL 165
                    ALAP L + W     +W  S SGLRY+  SYR++
Sbjct: 119 VVEADVPGDALAPELGEGWVVEENDWQTSESGLRYQFLSYRKV 161


>tr|C4EMW1|C4EMW1_STRRS Tax_Id=479432 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Streptosporangium roseum DSM
           43021]
          Length = 167

 Score =  154 bits (389), Expect = 3e-36
 Identities = 87/169 (51%), Positives = 98/169 (57%), Gaps = 10/169 (5%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           +VGLIWAQ+ +GVIG D GIPWRLPED+AHFK  T+GH VVMGR+TWDSLP   RPL  R
Sbjct: 2   NVGLIWAQTLNGVIGADNGIPWRLPEDMAHFKATTLGHPVVMGRKTWDSLPPRFRPLSDR 61

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQAL-CPAEPD-----AETWVIGGAQIYALALPLANRC 116
           RN+VVTR    V  GA+  GS+ QAL   AEP      A  WVIGG +IY  AL  A   
Sbjct: 62  RNIVVTRDPHWVVEGAERAGSIAQALELAAEPSETAAPAAVWVIGGGEIYRAALGYAT-- 119

Query: 117 XXXXXXXXXXXXXXXALAPVLDQTW-AGTSGEWLVSRSGLRYRMHSYRR 164
                            AP LD TW       W  S SGLRYR+  Y R
Sbjct: 120 -MLSVTEVDLTVNGDTYAPTLDSTWKVAEDRGWQSSTSGLRYRIRRYTR 167


>tr|C5BYZ5|C5BYZ5_BEUC1 Tax_Id=471853 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Beutenbergia cavernae]
          Length = 169

 Score =  150 bits (380), Expect = 3e-35
 Identities = 81/169 (47%), Positives = 102/169 (60%), Gaps = 10/169 (5%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           +G+IWAQ+  GVIG  G +PW +PED AHFK  T GH VVMGR TWDSLP  +RP+P RR
Sbjct: 2   IGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPERR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQAL--CPAEPDAETWVIGGAQIYALALPLANRCXXXXX 121
           NVVVTRQ    A GA+  GS+  AL  C AEP  ETW++GGAQIYA A+P A+       
Sbjct: 62  NVVVTRQVDWSADGAERAGSIPDALERCAAEP--ETWIMGGAQIYAEAMPYADTLVVTQL 119

Query: 122 XXXXXXXXXXAL--APVLDQTWAGTS----GEWLVSRSGLRYRMHSYRR 164
                      +  AP +   W   +    G W  SR+G+R+++H Y R
Sbjct: 120 DLALDVEGAPDVVHAPPIGPEWRIATDTWDGTWQTSRTGVRWQVHQYVR 168


>tr|Q6AFI1|Q6AFI1_LEIXX Tax_Id=59736 (folA)SubName:
           Full=Dihydrofolate reductase;[Leifsonia xyli subsp.
           xyli]
          Length = 159

 Score =  150 bits (379), Expect = 4e-35
 Identities = 81/162 (50%), Positives = 96/162 (59%), Gaps = 4/162 (2%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           S+ LIWAQ+ + VIG  G +PWRLPEDL HF+ LT G  VVMGRRTW+SLP   RPLPGR
Sbjct: 2   SIALIWAQARNRVIGAGGTMPWRLPEDLRHFRELTGGEPVVMGRRTWESLPDRFRPLPGR 61

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXX 122
           RN+VVTRQ G  A GA+V  +L  AL  A  D   WVIGG ++Y  ALPLA+R       
Sbjct: 62  RNIVVTRQEGWNAPGAEVAHALPGALSAASDDT-VWVIGGGELYRQALPLADRVEVTEID 120

Query: 123 XXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                      AP L   W      WL + +G+RYR   Y R
Sbjct: 121 LAVAGDTP---APALGPEWHAQPTPWLTAENGMRYRFLRYLR 159


>tr|C1B0L0|C1B0L0_RHOOB Tax_Id=632772 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Rhodococcus
           opacus]
          Length = 163

 Score =  149 bits (376), Expect = 1e-34
 Identities = 79/163 (48%), Positives = 101/163 (61%), Gaps = 7/163 (4%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           V L+WAQ + GVIGRD  IPW +PED+A+FK++T GH V+MGRRTWDSLP   RPLPGRR
Sbjct: 5   VKLVWAQGSGGVIGRDNTIPWHVPEDMAYFKKVTQGHPVIMGRRTWDSLPPRFRPLPGRR 64

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           N+V++RQ    A GA+    +  AL  A  D +  VIGG QIY  A+P A +        
Sbjct: 65  NIVISRQPDWAAEGAESADGIASAL--ALTDEDVCVIGGGQIYTAAMPFATQ---LLVSE 119

Query: 124 XXXXXXXXALAPVLDQTW-AGTSGEWLVS-RSGLRYRMHSYRR 164
                   A AP +D +W A  +GEWL S ++G RYR  +Y R
Sbjct: 120 IDVSIDGDAWAPPIDDSWHAQDTGEWLTSEKNGTRYRWITYTR 162


>tr|B9MG01|B9MG01_DIAST Tax_Id=535289 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Diaphorobacter sp.]
          Length = 164

 Score =  149 bits (375), Expect = 1e-34
 Identities = 82/163 (50%), Positives = 97/163 (59%), Gaps = 5/163 (3%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           V LI+A++ +GVIG++G +PW LPEDLAHFK LT GH V+MGR+TWDSLP   RPLPGR 
Sbjct: 3   VNLIYARAANGVIGKNGTMPWHLPEDLAHFKALTQGHPVIMGRKTWDSLPPRFRPLPGRA 62

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAET--WVIGGAQIYALALPLANRCXXXXX 121
           N+VVTRQ      GAQ   SL +AL  A+    T  WVIGGAQIYA ALPLA R      
Sbjct: 63  NIVVTRQADWQESGAQRASSLPEALALAQQSGSTTAWVIGGAQIYAQALPLATR---VEV 119

Query: 122 XXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                     A AP L   W  T+    V   GL Y   ++ R
Sbjct: 120 TEIAQDYEGDAYAPALGPEWVETARSNHVGAGGLPYAFVTFER 162


>tr|A1W5A2|A1W5A2_ACISJ Tax_Id=232721 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Acidovorax sp.]
          Length = 164

 Score =  149 bits (375), Expect = 1e-34
 Identities = 82/161 (50%), Positives = 96/161 (59%), Gaps = 5/161 (3%)

Query: 6   LIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRRNV 65
           LI+A++ +GVIG+DG +PW LPEDLAHFK LT GH V+MGR+TWDSLP   RPLPGR N+
Sbjct: 5   LIYARAANGVIGKDGTMPWHLPEDLAHFKALTQGHPVIMGRKTWDSLPPRFRPLPGRANI 64

Query: 66  VVTRQTGLVAHGAQVVGSLEQALCPAEPDAET--WVIGGAQIYALALPLANRCXXXXXXX 123
           VVTRQ      GAQ   SL +AL  A+    T  WVIGGAQIYA ALPLA R        
Sbjct: 65  VVTRQADWQESGAQRASSLPEALALAQQSGSTTAWVIGGAQIYAQALPLAAR---VEVTE 121

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   A AP L   W  T+    V   GL Y   ++ R
Sbjct: 122 IARDYEGDAYAPALGPEWVETARSSHVGAGGLPYAFVTFER 162


>tr|Q0SEI0|Q0SEI0_RHOSR Tax_Id=101510 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Rhodococcus sp.]
          Length = 168

 Score =  147 bits (372), Expect = 3e-34
 Identities = 80/163 (49%), Positives = 100/163 (61%), Gaps = 7/163 (4%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           V L+WAQ   GVIG D  IPW +PED+A+FK++T GH V+MGRRTWDSLP   RPLPGRR
Sbjct: 6   VKLVWAQGVGGVIGLDNTIPWHVPEDMAYFKQVTQGHPVIMGRRTWDSLPPRFRPLPGRR 65

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           N+V++RQ    A GA+    L  AL  A  D +  VIGGAQIY  A+P A +        
Sbjct: 66  NIVISRQPDWTAEGAESADGLGSAL--ALTDEDVCVIGGAQIYTAAMPFATQ---LLVSE 120

Query: 124 XXXXXXXXALAPVLDQTW-AGTSGEWLVS-RSGLRYRMHSYRR 164
                   A AP +D +W A  +GEWL S ++G RYR  +Y R
Sbjct: 121 IDVTIDGDAWAPPIDDSWHAQDTGEWLTSAKNGTRYRWITYTR 163


>tr|C3JX49|C3JX49_RHOER Tax_Id=596309 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Rhodococcus
           erythropolis SK121]
          Length = 163

 Score =  146 bits (369), Expect = 6e-34
 Identities = 82/164 (50%), Positives = 101/164 (61%), Gaps = 7/164 (4%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           +V LIWAQ+  GVIG D  IPWR+ ED+A+FKR+TMGH V+MGRRTWDS+P+  RP  GR
Sbjct: 5   TVTLIWAQAHGGVIGADNSIPWRVSEDMAYFKRVTMGHPVIMGRRTWDSIPSKFRPFSGR 64

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXX 122
           RN+VVTR     A GA+VV SL+ AL  A PD + +V+GG QIY+ ALP A         
Sbjct: 65  RNIVVTRDPQWHAEGAEVVRSLDDAL--ALPDGDVFVVGGGQIYSAALPFATH---LLVT 119

Query: 123 XXXXXXXXXALAPVLDQTWAGTSGE-WLVS-RSGLRYRMHSYRR 164
                    A AP +   W   S E W  S +SGLR+R   Y R
Sbjct: 120 EIDLDIAGDAFAPEIGPEWNLKSDEPWQTSEKSGLRFRWLEYTR 163


>tr|Q5YPL6|Q5YPL6_NOCFA Tax_Id=37329 (dfrA)SubName: Full=Putative
           dihydrofolate reductase;[Nocardia farcinica]
          Length = 171

 Score =  145 bits (365), Expect = 2e-33
 Identities = 78/163 (47%), Positives = 101/163 (61%), Gaps = 5/163 (3%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           ++GLIWAQ+T GVIG +  IPWR+PED+A+F+ +T GH V+MGRRTWDSLP   RPL GR
Sbjct: 9   TIGLIWAQTTDGVIGFENTIPWRVPEDMANFRTVTWGHPVIMGRRTWDSLPPKFRPLAGR 68

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXX 122
           RNVVVTRQ    A GA+  GSL +AL   EP++  W+ GGAQIY  A+  A         
Sbjct: 69  RNVVVTRQPDWSAPGAERAGSLTEALALTEPES-VWIAGGAQIYETAMDFATE---LLVT 124

Query: 123 XXXXXXXXXALAPVLDQTW-AGTSGEWLVSRSGLRYRMHSYRR 164
                    A APV+   W    +G    S +GL++R++ Y R
Sbjct: 125 EVQVSVQGDAHAPVIGAQWRLAEAGPERTSTTGLKFRINRYVR 167


>tr|A1VQZ7|A1VQZ7_POLNA Tax_Id=365044 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Polaromonas naphthalenivorans]
          Length = 166

 Score =  145 bits (365), Expect = 2e-33
 Identities = 78/161 (48%), Positives = 96/161 (59%), Gaps = 3/161 (1%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           + LI+A++ +GVIGR+  +PW LPEDLAHFKRLT G  V+MGR+TWDSLP   RPLPGR 
Sbjct: 6   INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPPRFRPLPGRT 65

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           N+V+TRQ    A GA    SL  AL       E WVIGGAQIYA A PLA+R        
Sbjct: 66  NLVITRQPDWQAPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADR---IEVTE 122

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   A AP L + W  T+ E  VS  GL +   ++ +
Sbjct: 123 IAQDFDGDAFAPPLGEEWQETAREAHVSSHGLPFSFVTFEK 163


>tr|A1TM51|A1TM51_ACIAC Tax_Id=397945 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Acidovorax avenae subsp.
           citrulli]
          Length = 165

 Score =  144 bits (362), Expect = 4e-33
 Identities = 83/163 (50%), Positives = 102/163 (62%), Gaps = 7/163 (4%)

Query: 6   LIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRRNV 65
           LI+A++ +G IG    +PW LPEDLAHFK+LT+G TVVMGR+TWDSLPA  RPLPGR N+
Sbjct: 5   LIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRTNI 64

Query: 66  VVTRQTGLVAHGAQVVGSLEQALCPAEPDAET-WVIGGAQIYALALPLANRCXXXXXXXX 124
           VVTRQ G  A GA    SLEQA+  A P  +T WV+GGAQIYA ALP+A+          
Sbjct: 65  VVTRQAGWHADGALSASSLEQAVELARPHGDTVWVMGGAQIYAQALPMAD---GVEVTEI 121

Query: 125 XXXXXXXALAPVLDQTWAGTSGEWLVSRSG---LRYRMHSYRR 164
                  A APVL   W  T+   + + +G   L +   SYRR
Sbjct: 122 HRDFEADAFAPVLGPEWEETARTPVQTSAGSAALPFSFVSYRR 164


>tr|C9Y9Z4|C9Y9Z4_9BURK Tax_Id=667019 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Curvibacter
           putative symbiont of Hydra magnipapillata]
          Length = 184

 Score =  143 bits (360), Expect = 7e-33
 Identities = 77/159 (48%), Positives = 96/159 (60%), Gaps = 3/159 (1%)

Query: 6   LIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRRNV 65
           LI+A++ +GVIG  G +PW LPEDLAHFKR T+G  V+MGR+TWDSLP   RPLPGR N+
Sbjct: 28  LIYARAANGVIGIHGTLPWHLPEDLAHFKRTTLGCPVIMGRKTWDSLPPKFRPLPGRANI 87

Query: 66  VVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXXXX 125
           VVTRQ      GAQ    L +AL   E   + WVIGGAQ+YALA P+A+           
Sbjct: 88  VVTRQPDWSETGAQRASELREALQLCEQATDVWVIGGAQLYALAEPVAHTA---VVTEIE 144

Query: 126 XXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                 A AP L + W  T+ E  V+ SGL +   +Y R
Sbjct: 145 KDFEGDAFAPTLGEAWQETARERHVAASGLPFSFVTYTR 183


>tr|A0JZC8|A0JZC8_ARTS2 Tax_Id=290399 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Arthrobacter sp.]
          Length = 194

 Score =  142 bits (359), Expect = 9e-33
 Identities = 81/174 (46%), Positives = 102/174 (58%), Gaps = 14/174 (8%)

Query: 2   TSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPG 61
           T VGL+WAQ+T+GVIG+DG +PW LPED+ HF RLT GH V+MGR+TW S P  +RPLPG
Sbjct: 21  TGVGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPDKYRPLPG 80

Query: 62  RRNVVVTRQTGL----VAHGAQVVGSLEQALCPAE--PDAET-WVIGGAQIYALALPLAN 114
           R N+VVTRQ G      A GA  V SL+ AL  ++  P  ET WV+GG +I+A  L +A+
Sbjct: 81  RTNIVVTRQEGWGDTPDARGAIAVKSLDDALLESQFAPGHETVWVLGGGEIFAQTLDIAD 140

Query: 115 RCXXXXXXXXXXXXXXXALAPVLDQTWAGTSGE----WLVSRSGLRYRMHSYRR 164
                              AP L   W   + E    WL S +G RYR   +RR
Sbjct: 141 ---VAVVTFIDSETDGDTYAPELGYEWKLAASEPATGWLTSATGTRYRFTMWRR 191


>tr|Q21U57|Q21U57_RHOFD Tax_Id=338969 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Rhodoferax ferrireducens]
          Length = 164

 Score =  142 bits (358), Expect = 1e-32
 Identities = 80/161 (49%), Positives = 99/161 (61%), Gaps = 7/161 (4%)

Query: 6   LIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRRNV 65
           LI+A+S +GVIG +G +PW LPEDLAHFKR T+G  V+MGR+TWDSLP   RPLPGR NV
Sbjct: 5   LIFARSANGVIGLNGKLPWHLPEDLAHFKRTTLGSPVIMGRKTWDSLPPKFRPLPGRLNV 64

Query: 66  VVTRQTGLVAHGAQVVGSLEQ--ALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           VVTRQ    A GA    SL +  ALCP+  D+  WVIGGA++Y  ALP+A+         
Sbjct: 65  VVTRQPHWQAAGALTAHSLAEACALCPS--DSHAWVIGGAELYLQALPMASTA---VVTE 119

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                   A AP     W  T+ E LVS +GL +   +Y R
Sbjct: 120 IDANFEGDAFAPQFGPQWRETARERLVSSTGLSFSFVTYCR 160


>tr|C0ZMB2|C0ZMB2_RHOE4 Tax_Id=234621 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Rhodococcus
           erythropolis]
          Length = 163

 Score =  142 bits (358), Expect = 1e-32
 Identities = 80/164 (48%), Positives = 99/164 (60%), Gaps = 7/164 (4%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           +V LIWAQ+  GVIG D  IPWR+ ED+A+FKR+TMGH V+MGRRTWDS+P   RP  GR
Sbjct: 5   TVTLIWAQAHDGVIGVDNTIPWRVSEDMAYFKRVTMGHPVIMGRRTWDSIPLKFRPFSGR 64

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXX 122
           RN+V+TR     A GA+VV  L+ AL  A PD + +V+GG QIY+ ALP A         
Sbjct: 65  RNIVITRDPQWQAEGAEVVHRLDDAL--ALPDGDVFVVGGGQIYSAALPFATH---LLVT 119

Query: 123 XXXXXXXXXALAPVLDQTWAGTSGE-WLVS-RSGLRYRMHSYRR 164
                    A AP +   W   S E W  S +SGLR+R   Y R
Sbjct: 120 EVDLDIAGDAFAPEIGPEWNLKSDEPWQTSEKSGLRFRWLEYTR 163


>tr|C1RGA1|C1RGA1_9CELL Tax_Id=446466 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Cellulomonas flavigena DSM 20109]
          Length = 168

 Score =  142 bits (357), Expect = 2e-32
 Identities = 78/166 (46%), Positives = 96/166 (57%), Gaps = 10/166 (6%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           +GL+WAQ+  GVIG  G IPW +PED+AHF+ +T G TVVMGR TW+SLP   RPLPGRR
Sbjct: 2   IGLVWAQTPEGVIGDAGAIPWHVPEDMAHFREVTAGGTVVMGRATWESLPQRFRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           NVV++R     A GA V+  LE AL  AE   + WVIGG  +YA  L  A+R        
Sbjct: 62  NVVLSRDAAYDAPGATVLDDLETALHSAE---DVWVIGGGAVYAATLDRADR---LEVTV 115

Query: 124 XXXXXXXXALAPVLDQTWAGTSG----EWLVSRSGLRYRMHSYRRL 165
                     AP +   W   SG     WLVSR+  RYR  S+ R+
Sbjct: 116 VDLDVPGDTRAPTIGPGWRRASGGPDTPWLVSRTATRYRFDSWVRV 161


>tr|A6WGF8|A6WGF8_KINRD Tax_Id=266940 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Kineococcus radiotolerans]
          Length = 171

 Score =  141 bits (356), Expect = 2e-32
 Identities = 77/162 (47%), Positives = 96/162 (59%), Gaps = 7/162 (4%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           +GL+WAQS +GVIG  G IPWR+PEDLAHF  LT G TVVMGR TW+SLPA  RPLPGRR
Sbjct: 2   IGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGRR 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           N+V++R  G  A GA+VV  L  AL  A    + WVIGG+ +Y  AL  A+         
Sbjct: 62  NLVLSRDPGYAAEGAEVVHDLPGALAGA---GDVWVIGGSAVYRAALEHAD---VLVVTE 115

Query: 124 XXXXXXXXALAPVLDQTWAGTS-GEWLVSRSGLRYRMHSYRR 164
                     AP +   W     G+W  S  G R+R+ ++RR
Sbjct: 116 VDLVVEGDTRAPEVGPGWERVEVGDWATSTGGPRFRIGTWRR 157


>tr|C1UIQ8|C1UIQ8_9ACTO Tax_Id=526225 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Geodermatophilus obscurus DSM
           43160]
          Length = 176

 Score =  141 bits (356), Expect = 2e-32
 Identities = 78/166 (46%), Positives = 94/166 (56%), Gaps = 8/166 (4%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           +VGL+WAQ+  GVIG DG +PW LPEDL  F+ LT G TVVMGRRTW+SLP   RPLPGR
Sbjct: 2   AVGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPERFRPLPGR 61

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXX 122
           RNVV+T      A GA+ V  +E  L   + D + WVIGG ++YA  LP A+R       
Sbjct: 62  RNVVLTTDRSWAADGAERVDGVEDVLARTD-DGDLWVIGGGRVYAAFLPHADR---VVVT 117

Query: 123 XXXXXXXXXALAPVLDQTWAGTS----GEWLVSRSGLRYRMHSYRR 164
                      AP L   WA  S      W  S +GLRY +  Y R
Sbjct: 118 DVDTDVEGDTWAPQLGAEWARVSRTPASGWSASTTGLRYAVSGYTR 163


>tr|A1WMP6|A1WMP6_VEREI Tax_Id=391735 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Verminephrobacter eiseniae]
          Length = 162

 Score =  141 bits (355), Expect = 3e-32
 Identities = 75/159 (47%), Positives = 96/159 (60%), Gaps = 3/159 (1%)

Query: 6   LIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRRNV 65
           LI+A++ +GVIG+DG +PW LP+D+AHF++LT G +V+MGR+TWDSLPA  RPLPGR N+
Sbjct: 5   LIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLPARFRPLPGRSNI 64

Query: 66  VVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXXXX 125
           VVTRQ+   A GA+   SLEQAL   +     WVIGGAQ+YA ALPLA+           
Sbjct: 65  VVTRQSDWHADGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLAD---CVEVTEIN 121

Query: 126 XXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                 A AP L   W          + GL +    Y R
Sbjct: 122 QDFDGDAHAPTLGAEWVEIRRSRQPDQHGLAFSFVRYAR 160


>tr|A4AHI2|A4AHI2_9ACTN Tax_Id=312284 SubName: Full=Dihydrofolate
           reductase;[marine actinobacterium PHSC20C1]
          Length = 176

 Score =  139 bits (351), Expect = 8e-32
 Identities = 76/168 (45%), Positives = 100/168 (59%), Gaps = 11/168 (6%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           ++GLIWAQS  GVIG+ G +PW+LPEDLAHFK+LT+G  V+MGR+TW SLP   RPLPGR
Sbjct: 4   ALGLIWAQSEGGVIGQGGTMPWQLPEDLAHFKKLTLGSPVIMGRKTWKSLPPRFRPLPGR 63

Query: 63  RNVVVTRQTGLVAHGAQVVGSLEQA---LCPAEPDAE-TWVIGGAQIYALALPLANRCXX 118
           RN+VVTRQ    A GA++  S++ A      +  D E  WVIGGA+IY   +  A+R   
Sbjct: 64  RNIVVTRQADWNADGAEIAHSVDAARELAATSVDDGEIVWVIGGAEIYRATIASAHR--- 120

Query: 119 XXXXXXXXXXXXXALAPVLDQTWAGTSGE----WLVSRSGLRYRMHSY 162
                         +AP L + W   + +    W  S +GL+YR   Y
Sbjct: 121 LEITQIRENFVGDTIAPELGEQWMLAASDPAEGWHTSTAGLQYRFERY 168


>tr|Q12CI7|Q12CI7_POLSJ Tax_Id=296591 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Polaromonas sp.]
          Length = 164

 Score =  139 bits (350), Expect = 1e-31
 Identities = 73/159 (45%), Positives = 93/159 (58%), Gaps = 3/159 (1%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           + +I+A++ +GVIG +  +PW LPED+AHFKRLT G  V+MGR+TWDSLP   RPLPGR 
Sbjct: 3   INMIFARAANGVIGNNNRMPWHLPEDMAHFKRLTQGWPVIMGRKTWDSLPPKFRPLPGRT 62

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           N+V+TRQ      GA+   SL  AL       E WVIGGAQIYA A PLA R        
Sbjct: 63  NIVITRQQDWKEDGAEPAASLADALSLCGQSEEVWVIGGAQIYAQAKPLAQR---IEVTE 119

Query: 124 XXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSY 162
                   A AP L   W   + E  +S +GL++   +Y
Sbjct: 120 IAQDFEGDAFAPPLGSEWIEAAREDHISSNGLKFSFITY 158


>tr|D1BJ51|D1BJ51_9MICO Tax_Id=446469 SubName: Full=Dihydrofolate
           reductase;[Sanguibacter keddieii DSM 10542]
          Length = 182

 Score =  139 bits (349), Expect = 1e-31
 Identities = 81/171 (47%), Positives = 97/171 (56%), Gaps = 13/171 (7%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           VGL+WAQ+  GVIG  G +PW LPED AHF+R T G  VVMGR TWDSLP   RPLPGR 
Sbjct: 10  VGLVWAQARDGVIGAGGTMPWHLPEDGAHFRRTTAGAAVVMGRATWDSLPERFRPLPGRT 69

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDA--ETWVIGGAQIYALALPLANRCXXXXX 121
           NVV+TR  GL   GA VVGSL++AL  A   A   TWV+GG ++Y  AL  A+       
Sbjct: 70  NVVLTRSPGLELTGAVVVGSLDEALAVAADAAPGRTWVMGGGEVYRQALAQAD---LLVV 126

Query: 122 XXXXXXXXXXALAPVLDQTW-----AGTSGE---WLVSRSGLRYRMHSYRR 164
                       AP +   W      G S +   W  SR+GLR+R   +RR
Sbjct: 127 TEIDTEVEGDTRAPEIGDGWDAEPVVGDSTDADGWSTSRTGLRFRFVEHRR 177


>tr|A9BMQ5|A9BMQ5_DELAS Tax_Id=398578 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Delftia acidovorans]
          Length = 166

 Score =  138 bits (348), Expect = 2e-31
 Identities = 79/160 (49%), Positives = 97/160 (60%), Gaps = 8/160 (5%)

Query: 3   SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGR 62
           ++ LI+A++ +GVIG+D  +PW LPEDLAHFK+LT G  VVMGR+TWDSLPA  RPLPGR
Sbjct: 2   AIHLIYARAANGVIGKDNAMPWHLPEDLAHFKQLTQGSAVVMGRKTWDSLPARFRPLPGR 61

Query: 63  RNVVVTRQTGL----VAHGAQVVGSLEQAL-CPAEPDAETWVIGGAQIYALALPLANRCX 117
            N+VVTRQ       VA G     SLEQA+    +  A+ WV+GGAQIYA ALPLA+   
Sbjct: 62  TNIVVTRQADWAPEPVAPGVLHATSLEQAMELGRQASADVWVMGGAQIYAQALPLAD--- 118

Query: 118 XXXXXXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRY 157
                         A AP L   W   S    V+ +GL Y
Sbjct: 119 SIEVTEIERDYEGDAFAPTLGPEWQEASRSRHVAANGLPY 158


>tr|C2AP27|C2AP27_TSUPA Tax_Id=521096 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Tsukamurella paurometabola DSM
           20162]
          Length = 158

 Score =  137 bits (346), Expect = 3e-31
 Identities = 78/162 (48%), Positives = 92/162 (56%), Gaps = 10/162 (6%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           +GLIWAQ+ SGVIG  GGIPW +PED+  F+  T G TVVMGR+TWDSLPA  RPLPGR 
Sbjct: 2   IGLIWAQARSGVIGDGGGIPWHIPEDMKFFRETTAGATVVMGRKTWDSLPARFRPLPGRT 61

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCXXXXXXX 123
           N+VVTR     A GA V   L        P+ + WVIGG +IYA ALP A+         
Sbjct: 62  NIVVTRDRDWSADGAVVHHEL------VLPEGDVWVIGGGEIYAAALPSAD---LLAVTE 112

Query: 124 XXXXXXXXALAPVLDQTWAGTSGE-WLVSRSGLRYRMHSYRR 164
                     AP +   +  T    W  S SGLRYR  +YRR
Sbjct: 113 VDADIPGDTYAPSIPDGFTATEDTGWRESTSGLRYRHLTYRR 154


>tr|C5CTW3|C5CTW3_VARPS Tax_Id=543728 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3; Flags: Precursor;[Variovorax
           paradoxus]
          Length = 177

 Score =  137 bits (344), Expect = 5e-31
 Identities = 81/166 (48%), Positives = 98/166 (59%), Gaps = 7/166 (4%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           + LI+A++ +GVIG  G IPW LPED+ HFK+ T G  VVMGR+TWDSLP   RPLPGRR
Sbjct: 10  IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPPRFRPLPGRR 69

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQ--ALCPAEPDAETWVIGGAQIYALALPLANRCXXXXX 121
           N+VVTRQ    A GA  VGSL++  ALC      + W+IGGAQIYA A PLA +      
Sbjct: 70  NIVVTRQDDWKAEGAWRVGSLQEALALCEESQVPDVWIIGGAQIYAEAEPLAQQ---VVV 126

Query: 122 XXXXXXXXXXALAPVLD-QTWAGTSGEWLVS-RSGLRYRMHSYRRL 165
                     A AP L    W  T  E  VS + GL Y   +Y R+
Sbjct: 127 TELAHDYEGDAHAPELSPSAWRETKREAHVSAKEGLNYSFVTYERI 172


>tr|A1R8Y8|A1R8Y8_ARTAT Tax_Id=290340 (folA)SubName:
           Full=Dihydrofolate reductase; EC=1.5.1.3;[Arthrobacter
           aurescens]
          Length = 175

 Score =  136 bits (343), Expect = 7e-31
 Identities = 74/175 (42%), Positives = 99/175 (56%), Gaps = 14/175 (8%)

Query: 1   MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLP 60
           MT +GL+WAQ+ SGVIG+DG +PW LPEDL HF +LT GH V+MGR+TW S P  +RPLP
Sbjct: 1   MTGIGLVWAQTKSGVIGKDGAMPWHLPEDLKHFSQLTTGHPVIMGRKTWLSFPEKYRPLP 60

Query: 61  GRRNVVVTRQ----TGLVAHGAQVVGSLEQALCP---AEPDAETWVIGGAQIYALALPLA 113
           GR N+VVTR     +   A GA VV SL+ AL     A    + W+IGG +I+  ++ +A
Sbjct: 61  GRTNIVVTRNAEWGSTPEAEGAVVVSSLDAALLESQFAPGGQKVWIIGGGEIFEQSMGIA 120

Query: 114 NRCXXXXXXXXXXXXXXXALAPVLDQTW----AGTSGEWLVSRSGLRYRMHSYRR 164
           N                   AP L   W       +  WL +++G  YR  ++RR
Sbjct: 121 N---LAVITIIDADLEGDTYAPELGDDWTFDAVAPADGWLTAKNGTNYRFTTWRR 172


>tr|C5T5W4|C5T5W4_ACIDE Tax_Id=573060 SubName: Full=Dihydrofolate
           reductase; EC=1.5.1.3;[Acidovorax delafieldii 2AN]
          Length = 163

 Score =  135 bits (340), Expect = 1e-30
 Identities = 79/163 (48%), Positives = 95/163 (58%), Gaps = 5/163 (3%)

Query: 4   VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63
           V LI+A++ +GVIG+DG +PW LPED+AHFK+LT G  V+MGR+TWDSLP   RPLPGR 
Sbjct: 3   VHLIYARAANGVIGKDGTMPWHLPEDMAHFKQLTHGCPVIMGRKTWDSLPPRFRPLPGRT 62

Query: 64  NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAET--WVIGGAQIYALALPLANRCXXXXX 121
           N+V+TRQ       A+   SL  AL  AE    T  WVIGGAQIYA A PLA R      
Sbjct: 63  NIVITRQPEWNEIDAKRASSLRDALQIAEQSNATTVWVIGGAQIYAQAQPLAQR---VEV 119

Query: 122 XXXXXXXXXXALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164
                     A AP L   W  T+ E   S +GL +    Y R
Sbjct: 120 TEIAQDFDGDAHAPELGPEWVETAREAHTSTNGLAFAFVRYER 162


  Database: Amellifera_nr
    Posted date:  Feb 5, 2010  5:10 AM
  Number of letters in database: 3,846,993,858
  Number of sequences in database:  11,275,203
  
Lambda     K      H
   0.322    0.136    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 11275203
Number of Hits to DB: 1,222,637,884
Number of extensions: 43972567
Number of successful extensions: 86000
Number of sequences better than 10.0: 2368
Number of HSP's gapped: 84266
Number of HSP's successfully gapped: 2368
Length of query: 165
Length of database: 3,846,993,858
Length adjustment: 126
Effective length of query: 39
Effective length of database: 2,426,318,280
Effective search space: 94626412920
Effective search space used: 94626412920
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 75 (33.5 bits)