BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MMAR_3195 (488 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,275,203 sequences; 3,846,993,858 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|B2HGR8|B2HGR8_MYCMM Tax_Id=216594 (murD)RecName: Full=UDP-N-a... 798 0.0 tr|A0PTI9|A0PTI9_MYCUA Tax_Id=362242 (murD)RecName: Full=UDP-N-a... 783 0.0 sp|C1AQ71|MURD_MYCBT Tax_Id=561275 (murD)RecName: Full=UDP-N-ace... 618 e-175 sp|A1KKJ8|MURD_MYCBP Tax_Id=410289 (murD)RecName: Full=UDP-N-ace... 618 e-175 sp|Q7VEP7|MURD_MYCBO Tax_Id=1765 (murD)RecName: Full=UDP-N-acety... 618 e-175 tr|A5WPC7|A5WPC7_MYCTF Tax_Id=336982 RecName: Full=UDP-N-acetylm... 618 e-175 tr|C6DPQ3|C6DPQ3_MYCTK Tax_Id=478434 RecName: Full=UDP-N-acetylm... 616 e-174 sp|O06222|MURD_MYCTU Tax_Id=1773 (murD)RecName: Full=UDP-N-acety... 615 e-174 sp|A5U4I2|MURD_MYCTA Tax_Id=419947 (murD)RecName: Full=UDP-N-ace... 615 e-174 tr|A4KIT3|A4KIT3_MYCTU Tax_Id=395095 RecName: Full=UDP-N-acetylm... 614 e-174 tr|A2VJQ2|A2VJQ2_MYCTU Tax_Id=348776 RecName: Full=UDP-N-acetylm... 614 e-174 sp|A0QF50|MURD_MYCA1 Tax_Id=243243 (murD)RecName: Full=UDP-N-ace... 612 e-173 sp|Q73YQ6|MURD_MYCPA Tax_Id=1770 (murD)RecName: Full=UDP-N-acety... 610 e-172 sp|P57995|MURD_MYCLE Tax_Id=1769 (murD)RecName: Full=UDP-N-acety... 600 e-169 sp|B8ZQP8|MURD_MYCLB Tax_Id=561304 (murD)RecName: Full=UDP-N-ace... 600 e-169 sp|A0R018|MURD_MYCS2 Tax_Id=246196 (murD)RecName: Full=UDP-N-ace... 524 e-147 tr|A4TBF3|A4TBF3_MYCGI Tax_Id=350054 RecName: Full=UDP-N-acetylm... 518 e-145 sp|A1TAX0|MURD_MYCVP Tax_Id=350058 (murD)RecName: Full=UDP-N-ace... 504 e-140 tr|A3Q1M0|A3Q1M0_MYCSJ Tax_Id=164757 RecName: Full=UDP-N-acetylm... 486 e-135 tr|Q1B6W9|Q1B6W9_MYCSS Tax_Id=164756 RecName: Full=UDP-N-acetylm... 486 e-135 tr|A1UI56|A1UI56_MYCSK Tax_Id=189918 RecName: Full=UDP-N-acetylm... 486 e-135 tr|B1MP35|B1MP35_MYCA9 Tax_Id=561007 RecName: Full=UDP-N-acetylm... 455 e-126 sp|Q0SHR9|MURD_RHOSR Tax_Id=101510 (murD)RecName: Full=UDP-N-ace... 419 e-115 tr|C1AU57|C1AU57_RHOOB Tax_Id=632772 (murD)RecName: Full=UDP-N-a... 408 e-111 tr|C3JJ50|C3JJ50_RHOER Tax_Id=596309 (murD)RecName: Full=UDP-N-a... 398 e-109 tr|C1A0X7|C1A0X7_RHOE4 Tax_Id=234621 (murD)RecName: Full=UDP-N-a... 395 e-108 tr|C2ATS3|C2ATS3_TSUPA Tax_Id=521096 RecName: Full=UDP-N-acetylm... 390 e-106 sp|Q5YYY1|MURD_NOCFA Tax_Id=37329 (murD)RecName: Full=UDP-N-acet... 384 e-104 tr|D0LAT4|D0LAT4_GORB4 Tax_Id=526226 SubName: Full=UDP-N-acetylm... 332 7e-89 tr|C6WDE4|C6WDE4_ACTMD Tax_Id=446462 RecName: Full=UDP-N-acetylm... 314 1e-83 tr|C8XGY8|C8XGY8_NAKMY Tax_Id=479431 SubName: Full=UDP-N-acetylm... 310 3e-82 tr|A4FLW2|A4FLW2_SACEN Tax_Id=405948 (murD)RecName: Full=UDP-N-a... 306 3e-81 tr|C0WK95|C0WK95_9CORY Tax_Id=525260 (murD)RecName: Full=UDP-N-a... 305 1e-80 tr|A4QFM5|A4QFM5_CORGB Tax_Id=340322 RecName: Full=UDP-N-acetylm... 299 5e-79 tr|C6RAX1|C6RAX1_9CORY Tax_Id=553206 (murD)RecName: Full=UDP-N-a... 296 3e-78 tr|Q6M3S0|Q6M3S0_CORGL Tax_Id=1718 (murD)RecName: Full=UDP-N-ace... 296 4e-78 sp|Q8FNT8|MURD_COREF Tax_Id=152794 (murD)RecName: Full=UDP-N-ace... 291 2e-76 tr|C8NQ14|C8NQ14_COREF Tax_Id=196164 (murD)SubName: Full=UDP-N-a... 291 2e-76 sp|Q82AD8|MURD_STRAW Tax_Id=33903 (murD)RecName: Full=UDP-N-acet... 288 8e-76 tr|D1A7U8|D1A7U8_THECU Tax_Id=471852 SubName: Full=UDP-N-acetylm... 288 8e-76 sp|Q47QX1|MURD_THEFY Tax_Id=269800 (murD)RecName: Full=UDP-N-ace... 287 2e-75 tr|C7MV95|C7MV95_SACVD Tax_Id=471857 RecName: Full=UDP-N-acetylm... 285 7e-75 sp|Q9S2W9|MURD_STRCO Tax_Id=1902 (murD)RecName: Full=UDP-N-acety... 283 3e-74 tr|C3PHF8|C3PHF8_CORA7 Tax_Id=548476 (murD)RecName: Full=UDP-N-a... 283 4e-74 tr|C0E4N1|C0E4N1_9CORY Tax_Id=566549 RecName: Full=UDP-N-acetylm... 283 4e-74 sp|Q6NGC6|MURD_CORDI Tax_Id=1717 (murD)RecName: Full=UDP-N-acety... 282 8e-74 tr|C5VD79|C5VD79_9CORY Tax_Id=553207 (murD)RecName: Full=UDP-N-a... 280 3e-73 tr|C2BNI7|C2BNI7_9CORY Tax_Id=525264 (murD)RecName: Full=UDP-N-a... 280 3e-73 tr|C7QI97|C7QI97_CATAD Tax_Id=479433 RecName: Full=UDP-N-acetylm... 278 9e-73 tr|B5I4L0|B5I4L0_9ACTO Tax_Id=463191 RecName: Full=UDP-N-acetylm... 278 1e-72 >tr|B2HGR8|B2HGR8_MYCMM Tax_Id=216594 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium marinum] Length = 488 Score = 798 bits (2061), Expect = 0.0 Identities = 416/477 (87%), Positives = 416/477 (87%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA Sbjct: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQLAQPEASPESRYALVVTSPGFQPSTPVL GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 120 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 RRWLVV SMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL Sbjct: 121 RRWLVVTGTNGKTTTTSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP Sbjct: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGP Sbjct: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPVGVLDTLAAAALAR 300 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 FQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA Sbjct: 301 AVGVSADAIADAVASFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEA 420 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEA Sbjct: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEA 420 Query: 421 CGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 CGASVTKVDDVGGSLG SGDTVLLAPAGASFDQFTSYGDRGD Sbjct: 421 CGASVTKVDDVGGSLGARVMRAAVAAARNMARSGDTVLLAPAGASFDQFTSYGDRGD 477 >tr|A0PTI9|A0PTI9_MYCUA Tax_Id=362242 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium ulcerans] Length = 488 Score = 783 bits (2022), Expect = 0.0 Identities = 410/477 (85%), Positives = 411/477 (86%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA Sbjct: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQLAQPE S ESRYALVVTSPGFQPSTPVL GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQLAQPEPSSESRYALVVTSPGFQPSTPVLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 120 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 RRWLVV SMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL Sbjct: 121 RRWLVVTGTNGKTTTTSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP Sbjct: 181 RWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 APVRVGFRIG PAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGP Sbjct: 241 APVRVGFRIGTPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPVGVLDTLAAAALAR 300 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 FQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA Sbjct: 301 AVGVSADAIADAVASFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEA 420 GGLLKGASVDAEVARMA+RLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEA Sbjct: 361 GGLLKGASVDAEVARMAARLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEA 420 Query: 421 CGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 GASVTKVDDVGGSLG SGDTVLLAPAGASFDQFTSYGDRGD Sbjct: 421 YGASVTKVDDVGGSLGARVMRAAVAAARNMARSGDTVLLAPAGASFDQFTSYGDRGD 477 >sp|C1AQ71|MURD_MYCBT Tax_Id=561275 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 618 bits (1593), Expect = e-175 Identities = 329/483 (68%), Positives = 352/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 1 MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+TP+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQI--------TGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 112 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 113 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 172 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 173 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 232 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA GELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 233 AQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 292 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 293 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 352 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 353 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 412 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 413 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 472 Query: 475 RGD 477 RG+ Sbjct: 473 RGE 475 >sp|A1KKJ8|MURD_MYCBP Tax_Id=410289 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 618 bits (1593), Expect = e-175 Identities = 329/483 (68%), Positives = 352/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 1 MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+TP+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQI--------TGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 112 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 113 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 172 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 173 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 232 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA GELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 233 AQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 292 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 293 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 352 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 353 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 412 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 413 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 472 Query: 475 RGD 477 RG+ Sbjct: 473 RGE 475 >sp|Q7VEP7|MURD_MYCBO Tax_Id=1765 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium bovis] Length = 486 Score = 618 bits (1593), Expect = e-175 Identities = 329/483 (68%), Positives = 352/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 1 MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+TP+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQI--------TGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 112 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 113 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 172 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 173 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 232 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA GELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 233 AQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 292 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 293 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 352 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 353 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 412 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 413 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 472 Query: 475 RGD 477 RG+ Sbjct: 473 RGE 475 >tr|A5WPC7|A5WPC7_MYCTF Tax_Id=336982 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis] Length = 486 Score = 618 bits (1593), Expect = e-175 Identities = 329/483 (68%), Positives = 352/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 1 MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+TP+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQI--------TGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 112 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 113 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 172 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 173 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 232 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA GELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 233 AQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 292 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 293 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 352 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 353 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 412 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 413 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 472 Query: 475 RGD 477 RG+ Sbjct: 473 RGE 475 >tr|C6DPQ3|C6DPQ3_MYCTK Tax_Id=478434 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis] Length = 489 Score = 616 bits (1589), Expect = e-174 Identities = 328/483 (67%), Positives = 352/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 +LDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 4 VLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 63 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+TP+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 64 VQQI--------TGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 115 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 116 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 175 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 176 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 235 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA GELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 236 AQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 295 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 296 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 355 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 356 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 415 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 416 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 475 Query: 475 RGD 477 RG+ Sbjct: 476 RGE 478 >sp|O06222|MURD_MYCTU Tax_Id=1773 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium tuberculosis] Length = 486 Score = 615 bits (1585), Expect = e-174 Identities = 328/483 (67%), Positives = 351/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 1 MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+TP+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQI--------TGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 112 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 113 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 172 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 173 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 232 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA ELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 233 AQVRVGFRLGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 292 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 293 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 352 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 353 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 412 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 413 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 472 Query: 475 RGD 477 RG+ Sbjct: 473 RGE 475 >sp|A5U4I2|MURD_MYCTA Tax_Id=419947 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium tuberculosis] Length = 486 Score = 615 bits (1585), Expect = e-174 Identities = 328/483 (67%), Positives = 351/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 1 MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+TP+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 61 VQQI--------TGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 112 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 113 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 172 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 173 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 232 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA ELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 233 AQVRVGFRLGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 292 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 293 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 352 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 353 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 412 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 413 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 472 Query: 475 RGD 477 RG+ Sbjct: 473 RGE 475 >tr|A4KIT3|A4KIT3_MYCTU Tax_Id=395095 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis str. Haarlem] Length = 496 Score = 614 bits (1583), Expect = e-174 Identities = 327/483 (67%), Positives = 351/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 +LDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 11 VLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 70 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+ P+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 71 VQQI--------TGYALVVASPGFSPAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 122 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 123 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 182 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 183 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 242 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA GELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 243 AQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 302 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 303 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 362 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 363 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 422 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 423 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 482 Query: 475 RGD 477 RG+ Sbjct: 483 RGE 485 >tr|A2VJQ2|A2VJQ2_MYCTU Tax_Id=348776 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium tuberculosis C] Length = 496 Score = 614 bits (1583), Expect = e-174 Identities = 327/483 (67%), Positives = 351/483 (72%), Gaps = 14/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 +LDPL PGAPVLVAG RVTG+AV A LTRFGA PT+CDDDP MLRP AE G+ TV S A Sbjct: 11 VLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA 70 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 VQQ+ + YALVV SPGF P+ P+L GVPIWGDVELAWRLDAAGCYGPP Sbjct: 71 VQQI--------TGYALVVASPGFSPAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPP 122 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQL 180 R WLVV SMLHAML+AG R+VLCGNIGS VLDVL+EPA+LLAVELSSFQL Sbjct: 123 RSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQL 182 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HWAPSLRPEAG VLNIAEDHLDWH TMA YT AKARVLTG VAV GLDDSRAAAL D +P Sbjct: 183 HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSP 242 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 A VRVGFR+G PA GELG+RD HLVDRAFSDDL LLP +SIPVPGP Sbjct: 243 AQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALAR 302 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F+VGRHR+EVV V DGITYVDDSKATNPHAA ASVLAYPRVVW+A Sbjct: 303 SVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIA 362 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE- 419 GGLLKGAS+ AEVA MASRLVGAVLIG+DRA VAEALSRHAPDVPVVQVV ED M Sbjct: 363 GGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPAT 422 Query: 420 -----ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 AC V K D G ++G GDTVLLAPAGASFDQFT Y D Sbjct: 423 VEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYAD 482 Query: 475 RGD 477 RG+ Sbjct: 483 RGE 485 >sp|A0QF50|MURD_MYCA1 Tax_Id=243243 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium avium] Length = 489 Score = 612 bits (1577), Expect = e-173 Identities = 326/479 (68%), Positives = 350/479 (73%), Gaps = 11/479 (2%) Query: 2 LDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAV 61 L PL PGAPVLVAG +TGRAVLAAL RFGA PT+CDDDPA LR + +SGV TV S A Sbjct: 8 LAPLSPGAPVLVAGGGITGRAVLAALRRFGAAPTLCDDDPATLRGYVDSGVDTVSTSAAA 67 Query: 62 QQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPR 121 +++ SRYALVVTSPGF P+ P+ GVP+WGDVELAWRLDAAG YGPPR Sbjct: 68 ERI--------SRYALVVTSPGFAPTAPLPLAAAAAGVPVWGDVELAWRLDAAGHYGPPR 119 Query: 122 RWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLH 181 RWLVV SMLHAML A RS+LCGNIGSPVLDVL++PA+LLAVELSSFQLH Sbjct: 120 RWLVVTGTNGKTTTTSMLHAMLTAAGRRSLLCGNIGSPVLDVLDQPAELLAVELSSFQLH 179 Query: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPA 241 WAPSLRPE G VLNIAEDHLDWHGT+A Y AKARVL GRVAVVGLDDSRAAAL TA A Sbjct: 180 WAPSLRPEGGAVLNIAEDHLDWHGTLADYAAAKARVLDGRVAVVGLDDSRAAALLSTARA 239 Query: 242 PVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXX 301 PVRVGFR+G PA GELG+R G LVDRAF+DDL LLP SIPVPGP Sbjct: 240 PVRVGFRLGEPAAGELGVRGGQLVDRAFADDLTLLPVDSIPVPGPVGVLDALAAAALARC 299 Query: 302 XXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 F+VGRHR+EVV V DGITYVDDSKATNPHAAEASVLAYPRVVW+AG Sbjct: 300 VDVPASPIAEAIVSFRVGRHRAEVVAVADGITYVDDSKATNPHAAEASVLAYPRVVWIAG 359 Query: 362 GLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE-- 419 GLLKGASVDA VARMASRLVGAVLIG+DR EVAEALSRHAPDVPVV VVT EDA M Sbjct: 360 GLLKGASVDAVVARMASRLVGAVLIGRDRREVAEALSRHAPDVPVVHVVTGEDAGMDATP 419 Query: 420 -ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 GA+VTKV +GG LG GDTVLLAPA ASFDQF Y DRGD Sbjct: 420 VVFGANVTKVKHLGGDLGAAVMSAAVAAARDLAKPGDTVLLAPAAASFDQFAGYADRGD 478 >sp|Q73YQ6|MURD_MYCPA Tax_Id=1770 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium paratuberculosis] Length = 489 Score = 610 bits (1574), Expect = e-172 Identities = 325/479 (67%), Positives = 350/479 (73%), Gaps = 11/479 (2%) Query: 2 LDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAV 61 L PL PGAPVLVAG +TGRAVLAAL RFGA PT+CDDDPA LR + +SGV TV S A Sbjct: 8 LAPLSPGAPVLVAGGGITGRAVLAALRRFGAAPTLCDDDPATLRGYVDSGVDTVSTSAAA 67 Query: 62 QQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPR 121 +++ SRYALVVTSPGF P+ P+ GVP+WGDVELAWRLD AG YGPPR Sbjct: 68 ERI--------SRYALVVTSPGFAPTAPLPLAAAAAGVPVWGDVELAWRLDVAGHYGPPR 119 Query: 122 RWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLH 181 RWLVV SMLHAML A RS+LCGNIGSPVLDVL++PA+LLAVELSSFQLH Sbjct: 120 RWLVVTGTNGKTTTTSMLHAMLTAAGRRSLLCGNIGSPVLDVLDQPAELLAVELSSFQLH 179 Query: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPA 241 WAPSLRPE G VLNIAEDHLDWHGT+A Y AKARVL GRVAVVGLDDSRAAAL TA A Sbjct: 180 WAPSLRPEGGAVLNIAEDHLDWHGTLADYAAAKARVLDGRVAVVGLDDSRAAALLSTARA 239 Query: 242 PVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXX 301 PVRVGFR+G PA GELG+R G LVDRAF+DDL LLP SIPVPGP Sbjct: 240 PVRVGFRLGEPAAGELGVRGGQLVDRAFADDLTLLPVDSIPVPGPVGVLDALAAAALARC 299 Query: 302 XXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 F+VGRHR+EVV V DGITYVDDSKATNPHAAEASVLAYPRVVW+AG Sbjct: 300 VDVPASPIAEAIVSFRVGRHRAEVVAVADGITYVDDSKATNPHAAEASVLAYPRVVWIAG 359 Query: 362 GLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGE-- 419 GLLKGASVDAEVARMAS LVGAVLIG+DR EVAEALSRHAPDVPVV VVT EDA M Sbjct: 360 GLLKGASVDAEVARMASWLVGAVLIGRDRREVAEALSRHAPDVPVVHVVTGEDAGMDATP 419 Query: 420 -ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 GA+VTKV +GG LG GDTVLLAPAGASFDQF Y DRG+ Sbjct: 420 VVFGANVTKVKHLGGDLGAAVMSAAVAAARDLAKPGDTVLLAPAGASFDQFAGYADRGE 478 >sp|P57995|MURD_MYCLE Tax_Id=1769 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium leprae] Length = 490 Score = 600 bits (1547), Expect = e-169 Identities = 323/483 (66%), Positives = 351/483 (72%), Gaps = 10/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLD LVPGAPVLVAG VTGRAVLAALTRFG T+CDDDPA L+ +A++GVATV + A Sbjct: 1 MLDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQQYADNGVATVSAATA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 QQ+ + +Y LVVTSPGF P+TPVL VPIWGDVELAWRLDAAG YGPP Sbjct: 61 TQQMFERGR----KYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPP 116 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEE---PADLLAVELSS 177 RRWLVV SMLHAML A RS+LCGNIG PVLDVL E P+D LAVELSS Sbjct: 117 RRWLVVTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSS 176 Query: 178 FQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRD 237 FQLHWAPSLRPEAGVVLNIAEDHLDWH TMA YT AKARVLTGRVAVVGLDDSRAAAL Sbjct: 177 FQLHWAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLS 236 Query: 238 TAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXX 297 T APVRVGFR G PAVGELG+RDG+LVDRAF++DL L+P +SIPV GP Sbjct: 237 TTVAPVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAA 296 Query: 298 XXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVV 357 F++GRHR+EVV V DGI YVDDSKATNPHAA SVLAYPRVV Sbjct: 297 LARSVGVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVV 356 Query: 358 WVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADM 417 WVAGGLLKGASVDAEVARMA +LVGAVLIG+DRA VAEALSRHAP+VPVVQVV EDA M Sbjct: 357 WVAGGLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGM 416 Query: 418 ---GEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 G V + DVGG++G GDTVLLAPAGASFDQF+ Y D Sbjct: 417 HAVAVVSGTDVISISDVGGTIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYAD 476 Query: 475 RGD 477 RGD Sbjct: 477 RGD 479 >sp|B8ZQP8|MURD_MYCLB Tax_Id=561304 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium leprae] Length = 490 Score = 600 bits (1547), Expect = e-169 Identities = 323/483 (66%), Positives = 351/483 (72%), Gaps = 10/483 (2%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 MLD LVPGAPVLVAG VTGRAVLAALTRFG T+CDDDPA L+ +A++GVATV + A Sbjct: 1 MLDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQQYADNGVATVSAATA 60 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 QQ+ + +Y LVVTSPGF P+TPVL VPIWGDVELAWRLDAAG YGPP Sbjct: 61 TQQMFERGR----KYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPP 116 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEE---PADLLAVELSS 177 RRWLVV SMLHAML A RS+LCGNIG PVLDVL E P+D LAVELSS Sbjct: 117 RRWLVVTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSS 176 Query: 178 FQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRD 237 FQLHWAPSLRPEAGVVLNIAEDHLDWH TMA YT AKARVLTGRVAVVGLDDSRAAAL Sbjct: 177 FQLHWAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVAVVGLDDSRAAALLS 236 Query: 238 TAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXX 297 T APVRVGFR G PAVGELG+RDG+LVDRAF++DL L+P +SIPV GP Sbjct: 237 TTVAPVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAA 296 Query: 298 XXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVV 357 F++GRHR+EVV V DGI YVDDSKATNPHAA SVLAYPRVV Sbjct: 297 LARSVGVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPRVV 356 Query: 358 WVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADM 417 WVAGGLLKGASVDAEVARMA +LVGAVLIG+DRA VAEALSRHAP+VPVVQVV EDA M Sbjct: 357 WVAGGLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGM 416 Query: 418 ---GEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 G V + DVGG++G GDTVLLAPAGASFDQF+ Y D Sbjct: 417 HAVAVVSGTDVISISDVGGTIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYAD 476 Query: 475 RGD 477 RGD Sbjct: 477 RGD 479 >sp|A0R018|MURD_MYCS2 Tax_Id=246196 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium smegmatis] Length = 493 Score = 524 bits (1350), Expect = e-147 Identities = 287/483 (59%), Positives = 323/483 (66%), Gaps = 15/483 (3%) Query: 2 LDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAV 61 L PL PGA VLV GA +TGRAVL AL T+CDD+ L A GVA + P A+ Sbjct: 8 LAPLTPGARVLVTGAGITGRAVLGALAPLEVAATLCDDNADALAALAAKGVAVIAPGDAI 67 Query: 62 QQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPR 121 + YALVVTSPGF PS PVL GVPIWGDVELAWRLDAAG YGPPR Sbjct: 68 ASIGD--------YALVVTSPGFAPSAPVLAAAAAAGVPIWGDVELAWRLDAAGRYGPPR 119 Query: 122 RWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLH 181 RWLVV SMLH MLVAG RSVLCGNIG PVL VL++PA+LLAVELSSFQLH Sbjct: 120 RWLVVTGTNGKTTTTSMLHDMLVAGGRRSVLCGNIGDPVLAVLDQPAELLAVELSSFQLH 179 Query: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPA 241 WAPSLRPEAGVVLN+AEDHLDWHG+MAAY KARVL GRVAVVGLDD AA L TA A Sbjct: 180 WAPSLRPEAGVVLNVAEDHLDWHGSMAAYARDKARVLDGRVAVVGLDDPVAAGLLPTAAA 239 Query: 242 PVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXX 301 VRVGFR+G PA GELG+RDG L+DRAF D + L + I V GP Sbjct: 240 TVRVGFRLGDPAAGELGVRDGKLIDRAFDDGVELADCADIGVAGPIGVLDALGAAALARA 299 Query: 302 XXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 FQVGRHR+EVV VDG+ ++DDSKATNPHAA+AS+ AY RVVWVAG Sbjct: 300 VGVAPGAIGAALASFQVGRHRAEVVGTVDGVVFIDDSKATNPHAAQASITAYDRVVWVAG 359 Query: 362 GLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDA------ 415 GLLKGASVD V ++A+RL GAVLIG+DR VA+ALSRHAPDVPVV++V ED+ Sbjct: 360 GLLKGASVDELVRQVANRLAGAVLIGRDRQMVADALSRHAPDVPVVELVAGEDSGVLGTN 419 Query: 416 DMGEACGASVTKVDDVGG-SLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGD 474 + E+ G VT+V +VGG + GDTVLLAPAGASFDQF+ YG Sbjct: 420 ESIESVGDHVTRVIEVGGRPVSDAVMSAVVSAARDLASPGDTVLLAPAGASFDQFSGYGQ 479 Query: 475 RGD 477 RGD Sbjct: 480 RGD 482 >tr|A4TBF3|A4TBF3_MYCGI Tax_Id=350054 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium gilvum] Length = 487 Score = 518 bits (1334), Expect = e-145 Identities = 279/474 (58%), Positives = 321/474 (67%), Gaps = 12/474 (2%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G VLV GARVTG+A+LAALT GA T+ DD P L FA+ GV +DP+ AV+++A Sbjct: 11 GLSVLVTGARVTGQAILAALTPLGARATLTDDSPTALTAFAQQGVEVLDPAAAVERIAA- 69 Query: 68 EASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVX 127 + LVVTSPGF P+ PVL GVPIWGDVELAWRLD +G +GPPR+WLVV Sbjct: 70 -------FDLVVTSPGFPPTAPVLAAAADAGVPIWGDVELAWRLDRSGRFGPPRQWLVVT 122 Query: 128 XXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLHWAPSLR 187 SMLHAML + R+VLCGNIG PVL +LE+PAD+ AVELSSFQLHWAPSLR Sbjct: 123 GTNGKTTTTSMLHAMLESAGRRAVLCGNIGDPVLTLLEQPADVFAVELSSFQLHWAPSLR 182 Query: 188 PEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGF 247 PEAG VLN+AEDHLDWHG+MAAY KAR LTGRVAV GLDD AA L +APA V+VGF Sbjct: 183 PEAGAVLNVAEDHLDWHGSMAAYAADKARALTGRVAVGGLDDEIAAGLLGSAPAAVKVGF 242 Query: 248 RIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXXXX 307 R+GAP GE G+RDG L+D AF+D L L SIPV GP Sbjct: 243 RLGAPGPGEFGVRDGALIDNAFADGLELAAVDSIPVAGPVGVLNALAAAALARAVDVPAE 302 Query: 308 XXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGA 367 FQVGRHR+EVV V DGITYVDDSKATNPHAA AS+ AYPRVVW+AGG+LKGA Sbjct: 303 AIATALAGFQVGRHRAEVVAVADGITYVDDSKATNPHAARASIDAYPRVVWIAGGMLKGA 362 Query: 368 SVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGASVTK 427 SV+ V+ A LVGAVLIG+DRA VAEAL+RHAPDVPVV++VT ED+ + E + VT+ Sbjct: 363 SVEDLVSDSADHLVGAVLIGRDRAVVAEALARHAPDVPVVELVTGEDSGVLEKDESGVTR 422 Query: 428 VDDV----GGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 V V SL GD +LLAPAGASFDQFTSYG RGD Sbjct: 423 VTRVVQADSESLSDAVMAAAVRAARGLAAPGDAILLAPAGASFDQFTSYGHRGD 476 >sp|A1TAX0|MURD_MYCVP Tax_Id=350058 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Mycobacterium vanbaalenii] Length = 483 Score = 504 bits (1297), Expect = e-140 Identities = 274/480 (57%), Positives = 314/480 (65%), Gaps = 12/480 (2%) Query: 2 LDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAV 61 + P+ PGA VLV GA +TGRAVLAAL GA T+ DD P L A+ V +DP+ AV Sbjct: 1 MQPISPGAAVLVVGAGITGRAVLAALAPLGARATLTDDSPTALTASAQQRVEVLDPATAV 60 Query: 62 QQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPR 121 ++A + LVV SPG P+ P+ G+P+WGDVELAW LD +G +GPPR Sbjct: 61 DRIAD--------FDLVVVSPGIPPTAPIPVAAAAAGIPVWGDVELAWHLDRSGRFGPPR 112 Query: 122 RWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLH 181 +WLVV SML+AML AG R+VLCGNIG PVL L+ PAD+LAVELSSFQLH Sbjct: 113 QWLVVTGTNGKTTTTSMLYAMLQAGGRRAVLCGNIGDPVLSQLDRPADVLAVELSSFQLH 172 Query: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPA 241 WAPSLRPEAG VLN+AEDHLDWHG+MAAY KAR LTGRVAV GLDD+ AA L APA Sbjct: 173 WAPSLRPEAGAVLNVAEDHLDWHGSMAAYAGDKARALTGRVAVGGLDDAIAAGLLADAPA 232 Query: 242 PVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXX 301 PV+VGFR+G P GE G+RDG L+D AF DL L A +IPV GP Sbjct: 233 PVKVGFRLGDPGPGEFGVRDGVLIDNAFGRDLALADADTIPVAGPVGVLDALAAAALARA 292 Query: 302 XXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 F VGRHR+EVV V DGITYVDDSKATNPHAA+ASV A+PRVVWVAG Sbjct: 293 VDVPAAAIAEALATFHVGRHRAEVVAVADGITYVDDSKATNPHAAQASVSAFPRVVWVAG 352 Query: 362 GLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEAC 421 GLLKGASVD V RLVG VLIG+DRA V ALSRHAPDVPVV++VT ED+ + E Sbjct: 353 GLLKGASVDEMVEATKDRLVGVVLIGRDRAIVGNALSRHAPDVPVVELVTGEDSVVLEKD 412 Query: 422 GASVTKVDDV----GGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 + VT+V V +L SGDTVLLAPAGASFDQFT YG RGD Sbjct: 413 ESGVTRVTRVIQTGDRTLADAVMTAAVDAARGLATSGDTVLLAPAGASFDQFTGYGHRGD 472 >tr|A3Q1M0|A3Q1M0_MYCSJ Tax_Id=164757 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 486 bits (1251), Expect = e-135 Identities = 275/489 (56%), Positives = 314/489 (64%), Gaps = 21/489 (4%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 +++PL PGA VL+ GA +TGR+V A L G T+CDDDP L+ + A V A Sbjct: 5 VVEPLTPGARVLITGAGLTGRSVSAVLEPTGVRLTICDDDPLALQRLI-TPAAVVTTGEA 63 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 V +A YALVVTSPGF P+ PVL GVPIWGDVELAWRLD AG +GPP Sbjct: 64 VAGIAD--------YALVVTSPGFPPTAPVLSAAAAAGVPIWGDVELAWRLDRAGWFGPP 115 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--------EEPADLLA 172 RRWLVV SML+A+L A R +LCGNIG+PVLDVL +E +LLA Sbjct: 116 RRWLVVTGTNGKTTTTSMLYAILRAADRRVMLCGNIGNPVLDVLGESPRTRGDEEPELLA 175 Query: 173 VELSSFQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRA 232 VELSSFQLHWAPSLRP+AGVVLN+AEDHLDWHG+M AY KAR L GRVAV GLDD A Sbjct: 176 VELSSFQLHWAPSLRPDAGVVLNVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVA 235 Query: 233 AALRDTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXX 292 A L TA APVRVGFR+G P GELG+ DG LVD AF+D L L A I V GP Sbjct: 236 AELLTTAAAPVRVGFRLGPPGAGELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNA 295 Query: 293 XXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLA 352 F+VGRHR+EVV V G+T+VDDSKATNPHAA AS+ A Sbjct: 296 LAAAALARAVDVPAEAVAAALASFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAA 355 Query: 353 YPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTS 412 YPRVVW+AGGLLKG SVDA VA +A RL G VLIG+DRA VAEALSRHAPDVPVV++VT Sbjct: 356 YPRVVWIAGGLLKGVSVDALVAEVADRLTGVVLIGRDRAVVAEALSRHAPDVPVVELVTG 415 Query: 413 EDADM---GEACGASVTKVDDVGG-SLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQ 468 ED+ + E+ VT+V D GG L GD VLLAPAGASFDQ Sbjct: 416 EDSGVHGTTESAVNHVTRVIDTGGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQ 475 Query: 469 FTSYGDRGD 477 F+ Y RGD Sbjct: 476 FSGYTQRGD 484 >tr|Q1B6W9|Q1B6W9_MYCSS Tax_Id=164756 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 486 bits (1250), Expect = e-135 Identities = 274/489 (56%), Positives = 314/489 (64%), Gaps = 21/489 (4%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 +++PL PG VL+ GA +TGR+V A L G T+CDDDP L+ + A V A Sbjct: 5 VVEPLTPGVRVLITGAGLTGRSVSAVLEPTGVRLTICDDDPLALQRLI-TPAAVVTTGEA 63 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 V +A YALVVTSPGF P+ PVL GVPIWGDVELAWRLD AG +GPP Sbjct: 64 VAGIAD--------YALVVTSPGFPPTAPVLAAAAAAGVPIWGDVELAWRLDRAGWFGPP 115 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--------EEPADLLA 172 RRWLVV SML+A+L A R++LCGNIG+PVLDVL +E +LLA Sbjct: 116 RRWLVVTGTNGKTTTTSMLYAILRAADRRAMLCGNIGNPVLDVLGESPRTRGDEEPELLA 175 Query: 173 VELSSFQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRA 232 VELSSFQLHWAPSLRP+AGVVLN+AEDHLDWHG+M AY KAR L GRVAV GLDD A Sbjct: 176 VELSSFQLHWAPSLRPDAGVVLNVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVA 235 Query: 233 AALRDTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXX 292 A L TA APVRVGFR+G P GELG+ DG LVD AF+D L L A I V GP Sbjct: 236 AELLTTAAAPVRVGFRLGPPGAGELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNA 295 Query: 293 XXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLA 352 F+VGRHR+EVV V G+T+VDDSKATNPHAA AS+ A Sbjct: 296 LAAAALARAVDVPAEAVAAALASFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAA 355 Query: 353 YPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTS 412 YPRVVW+AGGLLKG SVDA VA +A RL G VLIG+DRA VAEALSRHAPDVPVV++VT Sbjct: 356 YPRVVWIAGGLLKGVSVDALVAEVADRLAGVVLIGRDRAVVAEALSRHAPDVPVVELVTG 415 Query: 413 EDADM---GEACGASVTKVDDVGG-SLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQ 468 ED+ + E+ VT+V D GG L GD VLLAPAGASFDQ Sbjct: 416 EDSGVHGTTESAVNHVTRVIDTGGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQ 475 Query: 469 FTSYGDRGD 477 F+ Y RGD Sbjct: 476 FSGYTQRGD 484 >tr|A1UI56|A1UI56_MYCSK Tax_Id=189918 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium sp.] Length = 495 Score = 486 bits (1250), Expect = e-135 Identities = 274/489 (56%), Positives = 314/489 (64%), Gaps = 21/489 (4%) Query: 1 MLDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVA 60 +++PL PG VL+ GA +TGR+V A L G T+CDDDP L+ + A V A Sbjct: 5 VVEPLTPGVRVLITGAGLTGRSVSAVLEPTGVRLTICDDDPLALQRLI-TPAAVVTTGEA 63 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 V +A YALVVTSPGF P+ PVL GVPIWGDVELAWRLD AG +GPP Sbjct: 64 VAGIAD--------YALVVTSPGFPPTAPVLAAAAAAGVPIWGDVELAWRLDRAGWFGPP 115 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--------EEPADLLA 172 RRWLVV SML+A+L A R++LCGNIG+PVLDVL +E +LLA Sbjct: 116 RRWLVVTGTNGKTTTTSMLYAILRAADRRAMLCGNIGNPVLDVLGESPRTRGDEEPELLA 175 Query: 173 VELSSFQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRA 232 VELSSFQLHWAPSLRP+AGVVLN+AEDHLDWHG+M AY KAR L GRVAV GLDD A Sbjct: 176 VELSSFQLHWAPSLRPDAGVVLNVAEDHLDWHGSMTAYARDKARALDGRVAVAGLDDPVA 235 Query: 233 AALRDTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXX 292 A L TA APVRVGFR+G P GELG+ DG LVD AF+D L L A I V GP Sbjct: 236 AELLTTAAAPVRVGFRLGPPGAGELGVHDGWLVDNAFADGLRLARADDIRVAGPVGVLNA 295 Query: 293 XXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLA 352 F+VGRHR+EVV V G+T+VDDSKATNPHAA AS+ A Sbjct: 296 LAAAALARAVDVPAEAVAAALASFEVGRHRAEVVAVSGGVTWVDDSKATNPHAARASIAA 355 Query: 353 YPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTS 412 YPRVVW+AGGLLKG SVDA VA +A RL G VLIG+DRA VAEALSRHAPDVPVV++VT Sbjct: 356 YPRVVWIAGGLLKGVSVDALVAEVADRLAGVVLIGRDRAVVAEALSRHAPDVPVVELVTG 415 Query: 413 EDADM---GEACGASVTKVDDVGG-SLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQ 468 ED+ + E+ VT+V D GG L GD VLLAPAGASFDQ Sbjct: 416 EDSGVHGTTESAVNHVTRVIDTGGRPLPDAVMRAAVDAARHLARPGDAVLLAPAGASFDQ 475 Query: 469 FTSYGDRGD 477 F+ Y RGD Sbjct: 476 FSGYTQRGD 484 >tr|B1MP35|B1MP35_MYCA9 Tax_Id=561007 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Mycobacterium abscessus] Length = 488 Score = 455 bits (1171), Expect = e-126 Identities = 254/477 (53%), Positives = 297/477 (62%), Gaps = 12/477 (2%) Query: 5 LVPGAPVLVAGARVTGRAVLAALTRF---GAIPTMCDDDPAMLRPFAESGVATVDPSVAV 61 L G VLV GARVTG AV+AALT G T+CDDD L+ ++G + + A Sbjct: 9 LTGGTRVLVCGARVTGDAVVAALTGLADLGLRITVCDDDEDALQRHRDAGHGALTTAAAQ 68 Query: 62 QQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPR 121 + +A + LV+ SPGF PS PV+ G+PIWGDVELAWRLDA+G YG P+ Sbjct: 69 RHMADQD--------LVIVSPGFGPSAPVVQAAVQAGLPIWGDVELAWRLDASGRYGRPK 120 Query: 122 RWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLH 181 RW+VV +M+H ML A S LCGNIG PVL+VL+ + LAVELSSFQLH Sbjct: 121 RWVVVTGTNGKTTTTAMVHDMLTAAGGTSALCGNIGDPVLNVLDRDVEFLAVELSSFQLH 180 Query: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPA 241 WAPS+RP AG VLN+AEDHLDWHG M YT KAR L G VAV GLDD+ A L A A Sbjct: 181 WAPSVRPVAGAVLNVAEDHLDWHGGMEGYTRDKARALDGEVAVAGLDDAIAGGLLAAAAA 240 Query: 242 PVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXX 301 PV+ GFR G PAVGELG+ DG LVDRAF D+ L+ S +PV GP Sbjct: 241 PVKAGFRAGEPAVGELGVLDGWLVDRAFGVDIPLIEVSKLPVGGPIGVLNALAAAALARA 300 Query: 302 XXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 FQVGRHR+E++ V + YVDDSKATNPHAA AS+ YPRVVW+AG Sbjct: 301 VGTPAVHIARALEVFQVGRHRAELIARVADVAYVDDSKATNPHAAAASIAGYPRVVWIAG 360 Query: 362 GLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEAC 421 GLLKGA+VD V A RL VLIG+DRA +AEAL+RHAPDVPVV VVT EDA + EA Sbjct: 361 GLLKGAAVDDLVRDCADRLGAVVLIGRDRALIAEALARHAPDVPVVAVVTREDAGVQEAN 420 Query: 422 GASVTKVDDVGGS-LGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 VT D GG+ LG GDTVLLAPAGASFDQF+ Y +RGD Sbjct: 421 VVYVTDEADGGGADLGTRVMAAAVRHASSLARPGDTVLLAPAGASFDQFSGYSERGD 477 >sp|Q0SHR9|MURD_RHOSR Tax_Id=101510 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Rhodococcus sp.] Length = 499 Score = 419 bits (1078), Expect = e-115 Identities = 236/473 (49%), Positives = 289/473 (61%), Gaps = 8/473 (1%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G VLVAGA V+GRA + L GA+ T+ D + L A G ATV LA+ Sbjct: 13 GRSVLVAGAGVSGRATIEPLRDLGALVTVTDANVDALAECARLGAATVPID---DLLAER 69 Query: 68 EASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVX 127 + E +ALVVTSPGF+P P+L GVPIWGD+E +W +D AG YGPPRRWLVV Sbjct: 70 DRVAE--FALVVTSPGFRPDAPLLSLAAGDGVPIWGDIEFSWHVDRAGLYGPPRRWLVVT 127 Query: 128 XXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL---EEPADLLAVELSSFQLHWAP 184 SML ++L A + S+ CGNIG PVLD L E A+ LAVELSSFQLHWAP Sbjct: 128 GTNGKTTTTSMLQSILEAAELPSLACGNIGIPVLDALRQTEPRAEALAVELSSFQLHWAP 187 Query: 185 SLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVR 244 S+RP AG +LNIAEDHLDWHG M Y +AKAR LTG VAV+GLDD A++L ++PA Sbjct: 188 SVRPTAGAILNIAEDHLDWHGGMQPYIDAKARALTGEVAVLGLDDEVASSLFSSSPAVRT 247 Query: 245 VGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXX 304 VGFR+G PA GELG+ DG+LVDRAF+D L PA I PGP Sbjct: 248 VGFRLGVPAPGELGVEDGYLVDRAFADGERLAPAEGITPPGPAGLMDALAAAALARAIGV 307 Query: 305 XXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLL 364 VG HR+ +V V G+T+VDDSKATNPHAA S+LA+ RVVW+AGGLL Sbjct: 308 PPDAVAAGLAAHVVGPHRAALVAEVGGVTFVDDSKATNPHAARPSILAHERVVWIAGGLL 367 Query: 365 KGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGAS 424 KGA VD V +ASRL GAVL+G+D ++AE+L+RHAP+VPVV V T +DA + + Sbjct: 368 KGARVDDLVREVASRLAGAVLLGRDAMQIAESLARHAPEVPVVTVETGDDAGVSAVPQTA 427 Query: 425 VTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 +V + +GD+V+LAPA AS D F SYG RGD Sbjct: 428 THRVVLPADTDSDAVMGVVVREAAALATAGDSVVLAPAAASLDMFASYGHRGD 480 >tr|C1AU57|C1AU57_RHOOB Tax_Id=632772 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus opacus] Length = 499 Score = 408 bits (1048), Expect = e-111 Identities = 232/472 (49%), Positives = 282/472 (59%), Gaps = 8/472 (1%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G VLVAGA V+GRA + L GA T+ D + L A G ATV LA+ Sbjct: 13 GRSVLVAGAGVSGRATIEPLRDLGAHVTVTDSNVDALAECARRGAATVPID---DLLAER 69 Query: 68 EASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVX 127 E E +ALVVTSPGF+P P+L GVPIWGD+E +W +D AG YGPPRRWLVV Sbjct: 70 EKVAE--FALVVTSPGFRPDAPLLSAAAGDGVPIWGDIEFSWHVDRAGLYGPPRRWLVVT 127 Query: 128 XXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEP---ADLLAVELSSFQLHWAP 184 SML ++L A S+ CGNIG PVLD L A++LAVELSSFQLHWAP Sbjct: 128 GTNGKTTTTSMLQSILEAAGLPSLACGNIGLPVLDALRPTGPRAEVLAVELSSFQLHWAP 187 Query: 185 SLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVR 244 S+RP AG +LNIAEDHLDWHG M Y +AKAR LTG VAV+GLDD A++L ++ A Sbjct: 188 SVRPTAGAILNIAEDHLDWHGGMQPYIDAKARALTGEVAVLGLDDEVASSLFSSSLAVRT 247 Query: 245 VGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXX 304 +GFR+G PA GELG+ DG+LVDRAF+D L PA I PGP Sbjct: 248 LGFRLGVPAAGELGVEDGYLVDRAFADGERLAPADGITPPGPAGLMDALAAAALARAIGV 307 Query: 305 XXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLL 364 VG HR+ V V G+T+VDDSKATNPHAA S+LA+ RVVW+AGGLL Sbjct: 308 PPDAVAAGLAAHVVGPHRAARVAEVGGVTFVDDSKATNPHAARPSILAHDRVVWIAGGLL 367 Query: 365 KGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGAS 424 KGA VD V +A RL GAVL+G+D ++AE+L+RHAP+VPVV V T +DA + + Sbjct: 368 KGARVDDLVREVAGRLAGAVLLGRDARQIAESLARHAPEVPVVTVETGDDAGVSAVPQTA 427 Query: 425 VTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRG 476 +V + +GD V+LAPA AS D F SYG RG Sbjct: 428 THRVVLAADTDSDAVMGVVVREAAALASAGDAVVLAPAAASLDMFDSYGHRG 479 >tr|C3JJ50|C3JJ50_RHOER Tax_Id=596309 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus erythropolis SK121] Length = 507 Score = 398 bits (1023), Expect = e-109 Identities = 224/475 (47%), Positives = 278/475 (58%), Gaps = 12/475 (2%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G VLVAG RV+G+A + L GA+ T+ D AE G V + Sbjct: 16 GTRVLVAGGRVSGQATIEPLVALGAVVTVADSTLDFAERCAELGADMVTTTSI------- 68 Query: 68 EASPES--RYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLV 125 E +P+S Y LVVTSPGF+P P+L G+PIWGDVE +WR+D +G +G PR+WLV Sbjct: 69 EDAPDSITEYGLVVTSPGFRPDAPILAAAAGHGIPIWGDVEFSWRVDHSGHFGTPRKWLV 128 Query: 126 VXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPA---DLLAVELSSFQLHW 182 V SML ++L CGNIG P+LD L E + + LAVELSSFQLHW Sbjct: 129 VTGTNGKTTTTSMLASILDGAGVVGRACGNIGLPILDALAETSPRVEYLAVELSSFQLHW 188 Query: 183 APSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAP 242 APS+RP+AGVVLN+AEDHLDWHG M+AY EAK+R L+GRVAVVGLDD+ A+ L A A Sbjct: 189 APSVRPDAGVVLNVAEDHLDWHGGMSAYAEAKSRALSGRVAVVGLDDAIASELGTRATAD 248 Query: 243 VRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXX 302 + GFR+G P GELG+ GHLVD AF D + L A+SI GP Sbjct: 249 IVTGFRLGEPGEGELGVEAGHLVDNAFGDHVRLAEAASIDPAGPAGVMDALAAAALARAL 308 Query: 303 XXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGG 362 +VG HR +V V + Y+DDSKATNPHAA S+LA+ RVVWVAGG Sbjct: 309 GFEADVVERGLAAHKVGPHRGALVGRVGSVVYIDDSKATNPHAARPSILAHDRVVWVAGG 368 Query: 363 LLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACG 422 LLKGASVD V+ + RL GAVL+G+D + +AL+RHAPDVPVV V++ +DA + E Sbjct: 369 LLKGASVDQLVSEVGPRLSGAVLLGRDAGVIEDALARHAPDVPVVHVMSGDDAVVSENSS 428 Query: 423 ASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 S + G+ GD V+LAPA AS D F SYG RGD Sbjct: 429 NSTLTIRLPSGADADAVMAAVVVEAAELASPGDAVVLAPAAASLDMFASYGHRGD 483 >tr|C1A0X7|C1A0X7_RHOE4 Tax_Id=234621 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Rhodococcus erythropolis] Length = 507 Score = 395 bits (1016), Expect = e-108 Identities = 222/475 (46%), Positives = 279/475 (58%), Gaps = 12/475 (2%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G VLVAG RV+G+A + L GA+ T+ D + AE G V + Sbjct: 16 GTRVLVAGGRVSGQATIEPLVALGAVVTVADSTLDFAQRCAELGADMVTTTSI------- 68 Query: 68 EASPES--RYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLV 125 E +P+S Y LVVTSPGF+P P+L G+PIWGDVE +WR+D +G +G PR+WLV Sbjct: 69 EDAPDSITEYGLVVTSPGFRPDAPILAAAAGHGIPIWGDVEFSWRVDHSGHFGGPRKWLV 128 Query: 126 VXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPA---DLLAVELSSFQLHW 182 V SML ++L A CGNIG P+LD L E + + LAVELSSFQLHW Sbjct: 129 VTGTNGKTTTTSMLASILDAAGVVGRACGNIGLPILDALAETSPRVEYLAVELSSFQLHW 188 Query: 183 APSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAP 242 APS+RP+AGVVLN+AEDHLDWHG M+AY EAK+R L+G+VAVVGLDD+ A+ L A A Sbjct: 189 APSVRPDAGVVLNVAEDHLDWHGGMSAYAEAKSRALSGKVAVVGLDDAIASELGTRATAD 248 Query: 243 VRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXX 302 + GFR+G P GELG+ GHLVD AF D + L A+SI GP Sbjct: 249 IVTGFRLGEPGEGELGVEAGHLVDNAFGDHVRLAEAASIDPAGPAGVMDALAAAALARAL 308 Query: 303 XXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGG 362 +VG HR +V V + Y+DDSKATNPHAA S+LA+ RVVWVAGG Sbjct: 309 GFEADVVERGLAAHKVGPHRGALVGRVGSVVYIDDSKATNPHAARPSILAHDRVVWVAGG 368 Query: 363 LLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACG 422 LLKGASV+ V+ + RL GAVL+G+D + +AL+RHAPDVPVV V++ +D + E Sbjct: 369 LLKGASVEQLVSEVGPRLSGAVLLGRDAGVIEDALARHAPDVPVVHVLSGDDEAVSENSS 428 Query: 423 ASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 S + G+ GD V+LAPA AS D F SYG RGD Sbjct: 429 NSTLTIRLPSGADADAVMAAVVVEAAELASPGDAVVLAPAAASLDMFASYGHRGD 483 >tr|C2ATS3|C2ATS3_TSUPA Tax_Id=521096 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Tsukamurella paurometabola DSM 20162] Length = 486 Score = 390 bits (1001), Expect = e-106 Identities = 230/484 (47%), Positives = 282/484 (58%), Gaps = 30/484 (6%) Query: 7 PGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQ 66 PGA VLVAG VTG AV AL R GA T+ D +P A +A P VAV L Sbjct: 7 PGAHVLVAGGGVTGPAVARALLRLGAAVTVADG-----KPVAREKIAAEVPEVAVVDLDD 61 Query: 67 PEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVV 126 + + YALVV +PGF+P+ P++ GVP+ GDVELAW +D AG +G PR WLVV Sbjct: 62 LDPAG---YALVVVAPGFRPTAPIVVAAQDAGVPVIGDVELAWWIDRAGAFGAPRDWLVV 118 Query: 127 XXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPAD--LLAVELSSFQLHWAP 184 ML ++L +V CGNIG PV+D + + AD +LAVELSSFQLHWAP Sbjct: 119 TGTNGKTTTTQMLESILAHAGLPAVACGNIGRPVIDAIADAADPRVLAVELSSFQLHWAP 178 Query: 185 SLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVR 244 S+RP AGVVLNIAEDHLDWHG+MAAYT KAR LTG +AVVGLDD AA L P Sbjct: 179 SVRPRAGVVLNIAEDHLDWHGSMAAYTADKARALTGDIAVVGLDDPVAATL------PAA 232 Query: 245 VGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXX 304 GF +G PA G+ G+R G L+D A S ++PA+ + PGP Sbjct: 233 TGFTVGEPAPGQYGVRAGMLIDGAGSS---IVPAARVSPPGPAGIADALAATALAQAVGV 289 Query: 305 XXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLL 364 F+VG HR+E V V G+TY+DDSKATNPHAA+ S+ A+ RVVWVAGG L Sbjct: 290 TAAQAGAALTQFRVGAHRAEPVATVRGVTYIDDSKATNPHAAQNSIEAHERVVWVAGGQL 349 Query: 365 KGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDA-------DM 417 KGA +D VAR+ASRL GAVL+G D +A A++RHAPDVPVV+V + +D+ D Sbjct: 350 KGADIDPLVARVASRLAGAVLLGVDAELIAAAMARHAPDVPVVRVTSGDDSRVSPVTNDA 409 Query: 418 GEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDT----VLLAPAGASFDQFTSYG 473 + G SV V G +G + VLLAPA AS D F SYG Sbjct: 410 SRSIGTSVAGDVRVSGDADAVMTAAVHAAAGLADVAGQSRTPVVLLAPAAASLDMFRSYG 469 Query: 474 DRGD 477 RG+ Sbjct: 470 HRGE 473 >sp|Q5YYY1|MURD_NOCFA Tax_Id=37329 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Nocardia farcinica] Length = 480 Score = 384 bits (985), Expect = e-104 Identities = 219/471 (46%), Positives = 271/471 (57%), Gaps = 18/471 (3%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G VLVAG ++GR+++ L GA P + D L AE G+ V + Sbjct: 7 GRDVLVAGWGISGRSLVEPLRDIGAHPVVTDSGAKALAEAAELGLE-------VATSVEL 59 Query: 68 EASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVX 127 E++ SR+ALV+TSPG++P +PVL G+P+WGDVE AW +D A YGP R+WLVV Sbjct: 60 ESADLSRFALVITSPGWRPDSPVLVSAVTEGIPVWGDVEFAWWVDQARIYGPVRKWLVVT 119 Query: 128 XXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPA--DLLAVELSSFQLHWAPS 185 M HA+L A SV CGNIG P+LD L +LAVELSSFQLHWAPS Sbjct: 120 GTNGKTTTTQMTHAILRAAGIASVACGNIGLPILDALRRNPGPQVLAVELSSFQLHWAPS 179 Query: 186 LRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRV 245 +RPEAGVVLN+AEDHLDWHG + AY AKAR L GR+ VVGLDD AAAL + A V Sbjct: 180 VRPEAGVVLNVAEDHLDWHGGLDAYAAAKARALVGRIGVVGLDDPVAAALARRSKARRTV 239 Query: 246 GFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXX 305 GFR+G PA GELG+ DG L+DRAF+ +L I PGP Sbjct: 240 GFRVGVPADGELGVVDGKLLDRAFTKAAILAEVGDISPPGPAGVADALAAAALTRAIDVA 299 Query: 306 XXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLK 365 +VG HR+ V V G+ ++DDSKATNPHAA +S+LA+P VVW+AGG LK Sbjct: 300 PQFVKEGLQEHKVGPHRAAFVREVAGVEFIDDSKATNPHAARSSILAHPHVVWIAGGRLK 359 Query: 366 GASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGASV 425 GA+V+ V +A RLV AVLIG D +A AL+RHAP+VPVV+V +DA M + Sbjct: 360 GAAVEDLVEEVADRLVAAVLIGVDAPVIAAALARHAPEVPVVEVRAGDDAVMAD------ 413 Query: 426 TKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRG 476 D + +GDTVLLAPA AS D F Y RG Sbjct: 414 ---DPLRPDEADAVMAAAVRTAAGYARAGDTVLLAPAAASLDMFADYTHRG 461 >tr|D0LAT4|D0LAT4_GORB4 Tax_Id=526226 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase;[Gordonia bronchialis] Length = 512 Score = 332 bits (851), Expect = 7e-89 Identities = 212/507 (41%), Positives = 260/507 (51%), Gaps = 42/507 (8%) Query: 1 MLDPLV-PGAPVLVAGARVTGRAVLAALTRFGAIPTMCD------------DDPAMLRPF 47 M +PL+ G V+VAGA G + L GA T+ D A LR Sbjct: 1 MAEPLILDGRAVVVAGAGTAGMSAARFLLDAGAFVTLADARFAGEVAGSQIPGAAELRDR 60 Query: 48 AESGVATVDPSVAVQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVEL 107 +G+ TVD +A +R LVV SPGF P+ PV VP+WG+VEL Sbjct: 61 G-AGLVTVDDLLADDDWT-------ARTDLVVVSPGFAPTHPVAVAAADGSVPVWGEVEL 112 Query: 108 AWRLDAAGCYGPPRRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLD--VLE 165 AWR+D AG GPPR WLVV SML ++VAG + CGNIG PVLD ++ Sbjct: 113 AWRVDRAGILGPPRTWLVVTGTNGKTTTTSMLADIVVAGGRSGIACGNIGLPVLDAMLMA 172 Query: 166 EPADLLAVELSSFQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVV 225 D+L ELSSFQLHWAPS+RP+AGVVLN+AEDHLDWHG Y AK R LTG V+VV Sbjct: 173 PRVDVLCAELSSFQLHWAPSVRPDAGVVLNVAEDHLDWHGGFDGYAGAKTRALTGAVSVV 232 Query: 226 GLDDSRAAALRDTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPG 285 GLDD A L RVGF +G P +LG+ LVDRAF VLL A +I PG Sbjct: 233 GLDDEVAGGLPTQGR---RVGFTLGEPGPDDLGVVGAELVDRAFGSG-VLLAAEAIHPPG 288 Query: 286 PXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHA 345 P F+ HR EVV GI +VDDSKATNPHA Sbjct: 289 PSGLSDALAASALALAAGVDRAAVADALTAFRPAGHRGEVVAESAGIRFVDDSKATNPHA 348 Query: 346 AEASVLAYPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVP 405 A+A++ + RVV +AGGLLKGASVD + + RL G V IGQDR + +A++RHAP+VP Sbjct: 349 AQAAIAGFDRVVLIAGGLLKGASVDRMIDAVRHRLAGVVAIGQDRDIIVDAIARHAPEVP 408 Query: 406 VVQVVTSEDADMG---EACGASVTKV------------DDVGGSLGXXXXXXXXXXXXXX 450 V V T +D + AC ++ D ++ Sbjct: 409 TVTVFTGDDGGVNVHRMACARNLASARNHADPVSPGSPTDPAVAVMDRAVVEAWHLAGAA 468 Query: 451 XXSGDTVLLAPAGASFDQFTSYGDRGD 477 + VLLAPA AS D F YG RGD Sbjct: 469 DPTPQAVLLAPAAASLDMFAGYGRRGD 495 >tr|C6WDE4|C6WDE4_ACTMD Tax_Id=446462 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; Flags: Precursor;[Actinosynnema mirum] Length = 450 Score = 314 bits (805), Expect = 1e-83 Identities = 201/471 (42%), Positives = 245/471 (52%), Gaps = 40/471 (8%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAE--SGVATVDPSVAVQQLA 65 G LVAGA V GR+ AL GA T+ D L E GV V VA Sbjct: 6 GRSALVAGAGVAGRSAAEALLAAGATVTVTDSSADRLAAMGELLPGVDLVAGLVA----- 60 Query: 66 QPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLV 125 P LVVTSPG++P P+L GV + G+VELAWR+ AA PP WLV Sbjct: 61 -----PPEGVDLVVTSPGWRPDNPLLAASAAAGVEVIGEVELAWRM-AAELADPPA-WLV 113 Query: 126 VXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLHWAPS 185 V +ML ++L A ++ CGN+G PV+D L +LAVELSSFQLHW+PS Sbjct: 114 VTGTNGKTTTVTMLESILRAAGLDAIACGNVGLPVVDALLAGHRVLAVELSSFQLHWSPS 173 Query: 186 LRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRV 245 +RP AGV+LN+AEDHLDWHG++ AY AKA L G VA+ G+DD AAL +P V Sbjct: 174 VRPTAGVLLNVAEDHLDWHGSLEAYARAKAGALVGDVAIAGVDDPYVAALLTGSPGTAHV 233 Query: 246 GFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXX 305 G +G P G+LG+ G+LVDRAF D L + + GP Sbjct: 234 GITLGEPEEGQLGVAGGYLVDRAFGPDSRLAAVADVTPGGPPGIADALAAAALARAYGVA 293 Query: 306 XXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLK 365 F+ G HR VV V G+ YV+DSKATNPHAA AS+ ++ VVW+AGGLLK Sbjct: 294 PEAVRQGLLDFRPGDHRGVVVGEVGGVRYVNDSKATNPHAAVASLRSHESVVWIAGGLLK 353 Query: 366 GASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGASV 425 GASV V A RL AVLIG DRA +A AL+ HAP VPVV++ + M A A+ Sbjct: 354 GASVADLVRAEAHRLRAAVLIGADRAAIAAALAEHAPAVPVVELA---EGGMAGAVRAAA 410 Query: 426 TKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRG 476 GD VLLAPA AS D F Y RG Sbjct: 411 -----------------------GFARPGDAVLLAPAAASMDMFADYAHRG 438 >tr|C8XGY8|C8XGY8_NAKMY Tax_Id=479431 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase;[Nakamurella multipartita] Length = 485 Score = 310 bits (794), Expect = 3e-82 Identities = 204/485 (42%), Positives = 248/485 (51%), Gaps = 48/485 (9%) Query: 7 PGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQ 66 PG V+ AGA VTG V+ L G + + A A +G T A Sbjct: 14 PGDLVVAAGAGVTGLPVVRYLAARGVRVVVTANRAAPAELAAIAGDVT---------FAG 64 Query: 67 PEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYG---PPRRW 123 A+P + LV+TS G P+ P+L G+ + G+VELAWR+D G G PR W Sbjct: 65 DLATPPAGTTLVITSAGIPPTNPLLVAAAAAGIEVIGEVELAWRIDHDGPAGGQTAPRPW 124 Query: 124 LVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVL--------DVLEEPA--DLLAV 173 LVV ML ++L A CGNIG PVL D L++ D++AV Sbjct: 125 LVVTGTNGKTTTTGMLESILRAAGRTVTACGNIGWPVLAAVLAGGRDALDDTPRQDVIAV 184 Query: 174 ELSSFQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAA 233 ELSSFQLHWAPSLRP AGVVLN+AEDHLDWHG+MAAY KAR L G +A+ +DDS AA Sbjct: 185 ELSSFQLHWAPSLRPRAGVVLNLAEDHLDWHGSMAAYGADKARALAGEIALAVVDDSGAA 244 Query: 234 ALRDTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPAS-SIPVPGPXXXXXX 292 L A AP R+ AP G LGL DG LVD A++ L A+ ++ PG Sbjct: 245 GLLAGAGAPRRIPITAAAPVAGRLGLADGWLVDHAYAASAQRLAAAEAVRPPGAHNLTNA 304 Query: 293 XXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLA 352 F G HR+ +V G+ YVDDSKATNPHAA AS+LA Sbjct: 305 LAAAGLALAAGVPAQAVATGLAAFAPGGHRNVLVTQRAGVRYVDDSKATNPHAALASLLA 364 Query: 353 YPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVV-T 411 YPRVVW+AGG LKGA VD V + RL G VL+G D + A+SRHAPDVPV+ V T Sbjct: 365 YPRVVWIAGGQLKGAQVDELVLAVRDRLAGVVLLGVDAPVIHAAVSRHAPDVPVLPVPGT 424 Query: 412 SEDADMGEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTS 471 +D C A+ GD VLLAPA AS D F+S Sbjct: 425 DDDVMRSVVCAAA------------------------RMAAPGDVVLLAPAAASLDMFSS 460 Query: 472 YGDRG 476 Y RG Sbjct: 461 YAARG 465 >tr|A4FLW2|A4FLW2_SACEN Tax_Id=405948 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Saccharopolyspora erythraea] Length = 469 Score = 306 bits (785), Expect = 3e-81 Identities = 200/478 (41%), Positives = 246/478 (51%), Gaps = 42/478 (8%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQPEAS 70 +LVAGA V+GR+ AL GA T+ D L VA +L Sbjct: 1 MLVAGAGVSGRSAAEALLAAGASVTVSDASSDRL-------VALASLQAQGAELVPGLTE 53 Query: 71 PESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGP---------PR 121 P LVVTSPG++P +P+L GV + G+VELAWRLD P P Sbjct: 54 PPEGTDLVVTSPGWRPESPLLAATVAAGVELIGEVELAWRLDQEKANEPADSTGRPAGPA 113 Query: 122 RWLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLH 181 WL V ML ++L A V CGN+G PV+D + +LAVELSSFQLH Sbjct: 114 TWLAVTGTNGKTTTVGMLESILRADGVDVVACGNVGLPVVDAVRAGHRVLAVELSSFQLH 173 Query: 182 WAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGR-VAVVGLDDSRAAALRDT-A 239 W+ ++ P A VVLN+A DHLDWHG++ AY AKARV G VAV DD + L D A Sbjct: 174 WSQTVAPHASVVLNLAADHLDWHGSLDAYGAAKARVYAGNSVAVHNADDEWSVRLADAGA 233 Query: 240 PAPVR-VGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXX 298 P R V F + PA G LG+ G LVDRAF D + L + + GP Sbjct: 234 PQQARRVSFTLSDPAPGVLGVESGALVDRAFGDRVRLAAVADVHPAGPHNVANALAAASL 293 Query: 299 XXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVW 358 FQ G HRS VV G++YVDDSKATNPHAA+A++ A+P+VVW Sbjct: 294 ARAYGVEPEAVAEGLRSFQPGAHRSVVVAESAGVSYVDDSKATNPHAADAALRAHPKVVW 353 Query: 359 VAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMG 418 +AGGLLKGA V+ VA A+RL G VLIG+DRA AEAL+RHAPDVPV +V + +DA M Sbjct: 354 IAGGLLKGADVEDLVAANAARLAGVVLIGRDRARFAEALARHAPDVPVREVESGDDAGML 413 Query: 419 EACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRG 476 A + G V+LAPA AS D FT Y RG Sbjct: 414 AAVRLA-----------------------GEFAEPGCAVVLAPAAASMDMFTDYAHRG 448 >tr|C0WK95|C0WK95_9CORY Tax_Id=525260 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium accolens ATCC 49725] Length = 465 Score = 305 bits (780), Expect = 1e-80 Identities = 203/484 (41%), Positives = 250/484 (51%), Gaps = 43/484 (8%) Query: 2 LDPLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAES-GVATVDPSVA 60 L P + G VLVAGA V+GR +A L R G T+ D + A L AE GVATV Sbjct: 4 LPPFLRGR-VLVAGAGVSGRGCVAMLARLGVDTTVADSNAAALAALAEEFGVATVST--- 59 Query: 61 VQQLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPP 120 +A Y LVVTSPG++P + +L GV + GDVELA+RLD A +GPP Sbjct: 60 -------DAPAPGEYDLVVTSPGWRPDSALLDSFQAAGVEVIGDVELAYRLDRAEVFGPP 112 Query: 121 RRWLVVXXXXXXXXXXSMLHAMLVAGQHRSVL----CGNIGSPVLDVLEEP--ADLLAVE 174 R WLVV ML ++ A RS L GNIG + D L D+L E Sbjct: 113 RTWLVVTGTNGKTTTTGMLTKIMQADTARSGLRAQAVGNIGVSLFDALTASPRVDILCAE 172 Query: 175 LSSFQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAA 234 LSSFQLHW+ LRP+ GV+LN+AEDHLDWHG+ AY AKA+ L G AVVG DD AAA Sbjct: 173 LSSFQLHWSNELRPDVGVLLNVAEDHLDWHGSFDAYASAKAKALRGTRAVVGKDD--AAA 230 Query: 235 LRDTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLV-LLPASSIPVPGPXXXXXXX 293 R A GF G PA GE+G+ G LV R +D + L A I G Sbjct: 231 GRYAAGIDGVYGFTAGEPATGEVGVSAGRLVSRLDGEDAIDLASAEGIEPAGLAGVLDAA 290 Query: 294 XXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAY 353 + V HR VV G+ Y+D+SKATNPHAA+A++ + Sbjct: 291 AAASVARLAGASPAAIQEGLAAYAVAGHRGAVVHEHGGVAYIDNSKATNPHAADAALEGF 350 Query: 354 PRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSE 413 VVWVAGG LKGA VD +A A+RL AVL+G D++ +AEAL+R AP PV + E Sbjct: 351 NSVVWVAGGQLKGADVDELIATHAARLKAAVLVGIDKSIIAEALARRAPQTPVELI---E 407 Query: 414 DADMGEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYG 473 D D A A+V + +GDTVLLAPA AS D +T Sbjct: 408 DTDPQAAMNAAVGAAEQ-------------------HAEAGDTVLLAPAAASLDMYTGMA 448 Query: 474 DRGD 477 RGD Sbjct: 449 QRGD 452 >tr|A4QFM5|A4QFM5_CORGB Tax_Id=340322 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium glutamicum] Length = 472 Score = 299 bits (766), Expect = 5e-79 Identities = 176/470 (37%), Positives = 244/470 (51%), Gaps = 33/470 (7%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAES-GVATVDPSVAVQQLAQPEA 69 +LVAGA V+G ++ L+ + DD+ E VA + + A +QL Sbjct: 15 ILVAGAGVSGLSIAKMLSELHCDVVVADDNETARHMLIEVVDVADISTAQAQEQL----- 69 Query: 70 SPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXX 129 +++VVTSPG++P++ +L G+ + GDVELAWRLD AG +G P WL V Sbjct: 70 ---DSFSIVVTSPGWRPTSTLLVDAHRQGLEVIGDVELAWRLDQAGVFGEPHTWLAVTGT 126 Query: 130 XXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--EEPADLLAVELSSFQLHWAPSLR 187 SML AM+ G + GNIG PV + L + D+L ELSSFQLHW+P+ Sbjct: 127 NGKTTTTSMLAAMMNEGGFAAKAVGNIGIPVSEALVAKNRIDVLVAELSSFQLHWSPTFT 186 Query: 188 PEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGF 247 P+AGVVLN+AEDH+DWHG+M Y AK VL G+VA++G DD L A +GF Sbjct: 187 PDAGVVLNLAEDHIDWHGSMRDYALAKMEVLKGKVAIIGADDPYLVQLTSEADLSGLIGF 246 Query: 248 RIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXXXX 307 + PA G+LG++ G LVD A+ +++VL A I GP Sbjct: 247 TVNEPATGQLGVKAGELVDNAYGNNVVLASADGINPAGPAGVLDALAAAAVARSQGVAPE 306 Query: 308 XXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGA 367 F+V HR +VV DG+ ++D+SKATNPHAA++++ + V+WV GG LKGA Sbjct: 307 AIARALDSFEVAGHRGQVVAEHDGVHFIDNSKATNPHAADSALAGHDSVIWVVGGQLKGA 366 Query: 368 SVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGASVTK 427 + V + R+ A+++G DRAE+ AL HAP V ++ + EA VT+ Sbjct: 367 DIAPLVKKHEQRIKAALVLGADRAEIVAALKEHAPQ---ASVFVTDKTEPFEAMEEIVTE 423 Query: 428 VDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 + GDTVLLAPA AS D F G RGD Sbjct: 424 AFSIS-------------------EPGDTVLLAPAAASLDMFKGMGQRGD 454 >tr|C6RAX1|C6RAX1_9CORY Tax_Id=553206 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium tuberculostearicum SK141] Length = 463 Score = 296 bits (759), Expect = 3e-78 Identities = 194/475 (40%), Positives = 243/475 (51%), Gaps = 43/475 (9%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAES-GVATVDPSVAVQQLAQPEA 69 VLVAGA V+GR +A L G T+ D + L AE GVATV A Q Sbjct: 12 VLVAGAGVSGRGCVAMLASLGVDTTVADSNETALAELAEEFGVATVSVDSAAQ------- 64 Query: 70 SPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXX 129 + LVVTSPG++P +P+L GV + GDVELA+RLD AG +G PR WLVV Sbjct: 65 ---GDFDLVVTSPGWRPDSPLLVAFQDAGVEVIGDVELAYRLDRAGVFGAPRTWLVVTGT 121 Query: 130 XXXXXXXSMLHAMLVAGQHRS----VLCGNIGSPVLDVLEEP--ADLLAVELSSFQLHWA 183 ML ++ A R+ + GNIG + D L D+L ELSSFQLHW+ Sbjct: 122 NGKTTTTGMLAQIMQADAKRTGKRALAVGNIGVSLFDALTATPRVDVLCAELSSFQLHWS 181 Query: 184 PSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPV 243 LRP+ GV+LN+A+DHLDWHG+ AY AKA+VL+G VAVVG DD A A+R A Sbjct: 182 SHLRPDVGVLLNLADDHLDWHGSFDAYARAKAKVLSGDVAVVGKDD--AEAVRYAADTTD 239 Query: 244 RVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXX 303 GF P GE+G+ G LV R L A I G Sbjct: 240 FYGFTAAEPTQGEVGVSAGRLVSRLNEQREDLASAEGIEPAGLAGVLDAAAAASVARLAG 299 Query: 304 XXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGL 363 + V HR VV GIT++D+SKATNPHAA+A++ V+W+AGG Sbjct: 300 ATPESIAQGLAAYTVAGHRGAVVHEHSGITFIDNSKATNPHAADAALKGLNSVIWIAGGQ 359 Query: 364 LKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSED-ADMGEACG 422 LKGA VD VA+ A+ + AV++G DR EVA AL+ HAP PV + T E A M A Sbjct: 360 LKGAEVDGLVAKHAAHIKAAVVLGVDREEVARALAAHAPHAPVDVIETQEPFAAMHAAVE 419 Query: 423 ASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 A++ D +GDTVLLAPA AS D +T RGD Sbjct: 420 AALQHAD-----------------------AGDTVLLAPAAASLDMYTGMAQRGD 451 >tr|Q6M3S0|Q6M3S0_CORGL Tax_Id=1718 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium glutamicum] Length = 472 Score = 296 bits (758), Expect = 4e-78 Identities = 175/470 (37%), Positives = 243/470 (51%), Gaps = 33/470 (7%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAES-GVATVDPSVAVQQLAQPEA 69 +LVAGA V+G ++ L+ + DD+ E VA + + A +QL Sbjct: 15 ILVAGAGVSGLSIAKMLSELHCDVVVADDNETARHMLIEVVDVADISTAQAQEQL----- 69 Query: 70 SPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXX 129 +++VVTSPG++P++ +L G+ + GDVELAWRLD AG +G P WL V Sbjct: 70 ---DSFSIVVTSPGWRPTSTLLVDAHRQGLEVIGDVELAWRLDQAGVFGEPHTWLAVTGT 126 Query: 130 XXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--EEPADLLAVELSSFQLHWAPSLR 187 SML AM+ G + GNIG PV + L + D+L ELSSFQLHW+P+ Sbjct: 127 NGKTTTTSMLAAMMNEGGFTAKAVGNIGIPVSEALVAKNRIDVLVAELSSFQLHWSPTFT 186 Query: 188 PEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGF 247 P+AGVVLN+AEDH+DWHG+M Y AK VL G+VA++G DD L A +GF Sbjct: 187 PDAGVVLNLAEDHIDWHGSMRDYALAKMEVLKGKVAIIGADDPYLVQLTSEADLSGLIGF 246 Query: 248 RIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXXXX 307 + PA G+LG++ G LVD A+ +++VL A I GP Sbjct: 247 TVNEPATGQLGVKAGELVDNAYGNNVVLASADGINPAGPAGVLDALAAAAVARSQGVAPE 306 Query: 308 XXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGA 367 F+V HR +VV DG+ ++D+SKATNPHAA++++ + V+WV GG LKGA Sbjct: 307 AIARALDSFEVAGHRGQVVAEHDGVHFIDNSKATNPHAADSALAGHDSVIWVVGGQLKGA 366 Query: 368 SVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGASVTK 427 + V + R+ A+++G DRAE+ AL HA V ++ + EA VT+ Sbjct: 367 DIAPLVKKHEQRIKAALVLGADRAEIVAALKEHASQ---ASVFVTDKTEPFEAMEEIVTE 423 Query: 428 VDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 + GDTVLLAPA AS D F G RGD Sbjct: 424 AFSIS-------------------EPGDTVLLAPAAASLDMFKGMGQRGD 454 >sp|Q8FNT8|MURD_COREF Tax_Id=152794 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Corynebacterium efficiens] Length = 475 Score = 291 bits (744), Expect = 2e-76 Identities = 177/469 (37%), Positives = 240/469 (51%), Gaps = 31/469 (6%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQPEAS 70 +LV GA V+G + L G + +D+ E +D V + A+ Sbjct: 20 ILVTGAGVSGTGIAGMLHDLGLDVVVAEDNETSRHRLIE----LLDVDVVGTEHARASLG 75 Query: 71 PESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXXX 130 Y++VVTSPG++P +PVL G+ + GDVELAWRLD AG +G R WL V Sbjct: 76 D---YSIVVTSPGWRPDSPVLVDAASRGLEVIGDVELAWRLDRAGVFGVSRTWLAVTGTN 132 Query: 131 XXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLE--EPADLLAVELSSFQLHWAPSLRP 188 +ML AM+ G +V GNIG PV L + D++ ELSSFQLHWAP+L P Sbjct: 133 GKTTTTAMLAAMMKQGGFNAVAVGNIGVPVSAALTSCDRVDVMVAELSSFQLHWAPTLVP 192 Query: 189 EAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGFR 248 +AG+VLN+AEDH+DWHG+ Y AK RVLT VAV+G DDS L +GF Sbjct: 193 DAGLVLNLAEDHIDWHGSFRDYALAKTRVLTAPVAVIGADDSYLVELTTELGLSGLIGFT 252 Query: 249 IGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXXXXX 308 +G P +LG+ +GHLVD AF+ L L PA I GP Sbjct: 253 LGEPGPRQLGVLNGHLVDNAFAAQLPLAPADGINPSGPAGVLDALAAAAVARSQGVSAED 312 Query: 309 XXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGAS 368 F+V HR +VV G+ ++D+SKATNPHAA+ ++ V+W+ GG LKGA Sbjct: 313 IAGALATFEVSGHRGQVVAEDHGVQFIDNSKATNPHAADTALAGRESVIWIVGGQLKGAD 372 Query: 369 VDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGASVTKV 428 + VA A R+ A+++G DRAE+ A+ +HAPD +++V S D A++ ++ Sbjct: 373 ISELVATHAHRIKAALVLGADRAEIVTAVEQHAPDA-MIRVTDSTDP------VAAMREL 425 Query: 429 DDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 D GD VLLAPA AS D + G RGD Sbjct: 426 VD---------------HAFRFAEPGDCVLLAPAAASLDMYKGMGQRGD 459 >tr|C8NQ14|C8NQ14_COREF Tax_Id=196164 (murD)SubName: Full=UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium efficiens YS-314] Length = 475 Score = 291 bits (744), Expect = 2e-76 Identities = 177/469 (37%), Positives = 240/469 (51%), Gaps = 31/469 (6%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQPEAS 70 +LV GA V+G + L G + +D+ E +D V + A+ Sbjct: 20 ILVTGAGVSGTGIAGMLHDLGLDVVVAEDNETSRHRLIE----LLDVDVVGTEHARASLG 75 Query: 71 PESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXXX 130 Y++VVTSPG++P +PVL G+ + GDVELAWRLD AG +G R WL V Sbjct: 76 D---YSIVVTSPGWRPDSPVLVDAASRGLEVIGDVELAWRLDRAGVFGVSRTWLAVTGTN 132 Query: 131 XXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLE--EPADLLAVELSSFQLHWAPSLRP 188 +ML AM+ G +V GNIG PV L + D++ ELSSFQLHWAP+L P Sbjct: 133 GKTTTTAMLAAMMKQGGFNAVAVGNIGVPVSAALTSCDRVDVMVAELSSFQLHWAPTLVP 192 Query: 189 EAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGFR 248 +AG+VLN+AEDH+DWHG+ Y AK RVLT VAV+G DDS L +GF Sbjct: 193 DAGLVLNLAEDHIDWHGSFRDYALAKTRVLTAPVAVIGADDSYLVELTTELGLSGLIGFT 252 Query: 249 IGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXXXXX 308 +G P +LG+ +GHLVD AF+ L L PA I GP Sbjct: 253 LGEPGPRQLGVLNGHLVDNAFAAQLPLAPADGINPSGPAGVLDALAAAAVARSQGVSAED 312 Query: 309 XXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGAS 368 F+V HR +VV G+ ++D+SKATNPHAA+ ++ V+W+ GG LKGA Sbjct: 313 IAGALATFEVSGHRGQVVAEDHGVQFIDNSKATNPHAADTALAGRESVIWIVGGQLKGAD 372 Query: 369 VDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEACGASVTKV 428 + VA A R+ A+++G DRAE+ A+ +HAPD +++V S D A++ ++ Sbjct: 373 ISELVATHAHRIKAALVLGADRAEIVTAVEQHAPDA-MIRVTDSTDP------VAAMREL 425 Query: 429 DDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 D GD VLLAPA AS D + G RGD Sbjct: 426 VD---------------HAFRFAEPGDCVLLAPAAASLDMYKGMGQRGD 459 >sp|Q82AD8|MURD_STRAW Tax_Id=33903 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Streptomyces avermitilis] Length = 467 Score = 288 bits (738), Expect = 8e-76 Identities = 201/486 (41%), Positives = 249/486 (51%), Gaps = 51/486 (10%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDD-DPAMLRPFAESGVATVDPSVAVQQLAQ 66 G V VAG V+G L GA+ T+ +D D R A A ++ +L Sbjct: 6 GKNVTVAGLGVSGIPAARVLHGLGAVVTVVNDGDDERSRAQA----ADLEALGITVRLGD 61 Query: 67 PEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVV 126 PE L+VT+PG+QP P+ GVP+WGDVELAWRL G WL V Sbjct: 62 GATLPEGT-ELIVTTPGWQPDKPLFAAAAEAGVPVWGDVELAWRLRGPGS----APWLAV 116 Query: 127 XXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--EEPADLLAVELSSFQLHWAP 184 ML ++L A R+ GNIG +LD + EE D+LAVELSS+QLHWAP Sbjct: 117 TGTNGKTTTVQMLASILTAAGLRTAAVGNIGVSLLDAVLGEETYDVLAVELSSYQLHWAP 176 Query: 185 SLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTG-RVAVV-------GLDDSRAAALR 236 SLR + VLNIA DHLDWHG+M AYT K R+ G RVA V D RAA + Sbjct: 177 SLRAHSATVLNIAPDHLDWHGSMEAYTADKGRIYEGNRVACVYNVADKATEDLVRAADVE 236 Query: 237 DTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLV-----LLPASSIPVPGPXXXXX 291 + A VGF +G P +LG+ +G LVDRAF +D L + + P P Sbjct: 237 EGCRA---VGFTLGTPGPSQLGVVEGILVDRAFVEDRQKNAQELAEVADVHPPAPHNIAN 293 Query: 292 XXXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVL 351 F+ HR V VDG+TY+DDSKATN HAAEAS+ Sbjct: 294 ALAAAALARAFGVPASAVRDGLRAFRPDAHRIAHVADVDGVTYIDDSKATNTHAAEASLA 353 Query: 352 AYPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVT 411 AY +VW+AGGL KGAS D VA+ A RL G VLIG DRA + EAL+RHAP+VPVV + Sbjct: 354 AYGSIVWIAGGLAKGASFDELVAKSAQRLRGVVLIGADRALIREALARHAPEVPVVDL-- 411 Query: 412 SEDADMGEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTS 471 + D G A A+V + + +GDTVLLAPA AS D F + Sbjct: 412 -DRTDTG-AMPAAVQEARRLA-------------------VAGDTVLLAPACASMDMFAN 450 Query: 472 YGDRGD 477 Y RGD Sbjct: 451 YNKRGD 456 >tr|D1A7U8|D1A7U8_THECU Tax_Id=471852 SubName: Full=UDP-N-acetylmuramoylalanine/D-glutamate ligase; Flags: Precursor;[Thermomonospora curvata DSM 43183] Length = 469 Score = 288 bits (738), Expect = 8e-76 Identities = 194/477 (40%), Positives = 242/477 (50%), Gaps = 41/477 (8%) Query: 10 PVLVAGARVTGRAVLAALTRFGAIPTMCD--DDPAMLRPFAESGVATVDPSVAVQQLAQP 67 PV VAG ++GRA AL GA T+ D DD A E V +L Sbjct: 7 PVCVAGLGISGRAAARALAARGARVTVVDARDDAAAREQAGELRECGVQV-----RLGDG 61 Query: 68 EASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVX 127 +A PE LVV SPG++P P+ GV I+G+VELAWRL G WL + Sbjct: 62 DALPEGT-DLVVVSPGWRPDAPLPAAAAAAGVEIYGEVELAWRLSREDG-GRAAPWLALT 119 Query: 128 XXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPA-DLLAVELSSFQLHWAPSL 186 ML +L A HR+ GN+G+P+++ +P+ D+LAVELSS+QLHW+ SL Sbjct: 120 GTNGKTTTVRMLACILRAAGHRAPAVGNVGTPIVEAALDPSCDVLAVELSSYQLHWSSSL 179 Query: 187 RPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLT-GRVAVVGLDDSRAAALRDTAPAPVRV 245 PEAG VLN+A DHLDWHG++ AY K ++ G VAV DD + L A A V Sbjct: 180 APEAGAVLNVAPDHLDWHGSLEAYAADKGKIYAPGTVAVFNADDEISTRL--AAGAERAV 237 Query: 246 GFRIGAPAVGELGLRDGHLVDRAFSDD-----LVLLPASSIPVPGPXXXXXXXXXXXXXX 300 GF +G PA G+LG+ + LVDRAF+ D L S + P Sbjct: 238 GFTLGIPAPGQLGVVEDLLVDRAFTGDPRREAAELAQLSDVRPFAPHNVANALAAAALAR 297 Query: 301 XXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVA 360 F HR V V+G+ Y+DDSKATNPHAA AS+ A VW+A Sbjct: 298 AHGVPPQAVAEGLRAFVPDPHRIAHVATVNGVDYIDDSKATNPHAAAASLAACESAVWIA 357 Query: 361 GGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMGEA 420 GGLLKGA V V A RL AVLIG DRA++AEAL+RHAP+VPVV + + M Sbjct: 358 GGLLKGADVTELVRSCAPRLRAAVLIGADRAKIAEALARHAPEVPVVDIPDTHTGTMDIV 417 Query: 421 CGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 + GDTVLLAPAGASFD FTSYG RG+ Sbjct: 418 VAEAA-----------------------RLARPGDTVLLAPAGASFDMFTSYGARGE 451 >sp|Q47QX1|MURD_THEFY Tax_Id=269800 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Thermobifida fusca] Length = 465 Score = 287 bits (735), Expect = 2e-75 Identities = 193/485 (39%), Positives = 242/485 (49%), Gaps = 50/485 (10%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMC---DDDPAMLRPFAESGVATVDPSVAVQQL 64 G V V G V+G V AL + GA T+ DDD R T+ A +L Sbjct: 5 GRRVCVTGLGVSGPPVARALLKHGAHVTVVEGRDDDVNRER------ARTLRELGATVEL 58 Query: 65 AQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWL 124 +P P LVVTSPG++P PVL GV + GDVELAWRL AG + WL Sbjct: 59 GEPTTLPAGT-DLVVTSPGWRPDAPVLVAAADAGVEVIGDVELAWRLRPAG-----QVWL 112 Query: 125 VVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL----EEPADLLAVELSSFQL 180 V ML AML A R++ GN+G+PV+D + D+LAVELSSFQL Sbjct: 113 AVTGTNGKTTTVRMLEAMLRADGRRALAVGNVGTPVIDAALADGPDRWDILAVELSSFQL 172 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVL-TGRVAVVGLDDSRAAALRDTA 239 HW+ +++P A ++N+A DHLDWHG M Y AKA+V G + +V D L +T Sbjct: 173 HWSATVQPHAAAIINLAPDHLDWHGGMEPYAAAKAKVYGAGTIRIVNAADPALRELAETH 232 Query: 240 --PAPVRVGFRIGAPAVGELGLRDGHLVDRAF-----SDDLVLLPASSIPVPGPXXXXXX 292 PA VGF + P GELGL + LVDRAF ++ L + + P Sbjct: 233 GDPAAPLVGFSLDVPRAGELGLVEDLLVDRAFVANPRTEATELATLADVTPRAPHNVANA 292 Query: 293 XXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLA 352 FQ HR V +DG+ YVDDSKATN HAA AS+ A Sbjct: 293 LAAAALARSIGVAPEAVRTGLRNFQPEPHRIAHVATIDGVDYVDDSKATNAHAAAASLAA 352 Query: 353 YPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTS 412 YP VVW+AGGLLKGA V V + ASRL G VL+G DR ++ EAL HAP VPVV V + Sbjct: 353 YPSVVWIAGGLLKGADVTGLVRQAASRLRGVVLLGADRHQLREALDTHAPHVPVVDVART 412 Query: 413 EDADMGEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSY 472 ++ M E A+ GDTVLLAPA AS D FT+Y Sbjct: 413 DEGAMAEVVAAAARLAQ-----------------------KGDTVLLAPAAASMDMFTNY 449 Query: 473 GDRGD 477 +RG+ Sbjct: 450 IERGE 454 >tr|C7MV95|C7MV95_SACVD Tax_Id=471857 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Saccharomonospora viridis] Length = 458 Score = 285 bits (730), Expect = 7e-75 Identities = 195/479 (40%), Positives = 239/479 (49%), Gaps = 45/479 (9%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G V VAGA VTGR+V AL GA T+ D + L + GV V P + Sbjct: 5 GVAVCVAGAGVTGRSVATALVGMGAQVTVTDANAERLAELGDLGVRLV-PGLD------- 56 Query: 68 EASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGP-PRRWLVV 126 +P LVVTSPG++P+ P+L G+ + GDVELAWR+ G P P WL V Sbjct: 57 --TPPDGTRLVVTSPGWRPTAPLLTAAASSGIEVIGDVELAWRI---GQERPNPPTWLAV 111 Query: 127 XXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPADLLAVELSSFQLHWAPSL 186 M +ML + +V CGN+G VLD + L VELSSFQLHW+ SL Sbjct: 112 TGTNGKTTTVGMAESMLRSAGVDAVACGNVGFAVLDAVLAGHSTLVVELSSFQLHWSRSL 171 Query: 187 RPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVG-LDD--SRAAALRDTAPAPV 243 P A VVLN+AEDHLDWHG +A Y K + G VV L D SR A P Sbjct: 172 APSASVVLNVAEDHLDWHGGLAEYAADKGTIHRGSGTVVANLRDPWSRKLAEEHAPPEAR 231 Query: 244 RVGFRIGAPAVGELGLRDGHLVDRAFSDDLV-----LLPASSIPVPGPXXXXXXXXXXXX 298 RVGF + P GELG+ + LVDRAF D V L + + GP Sbjct: 232 RVGFTLDTPRPGELGVVEDLLVDRAFVADPVHAAEELGTLADVRPGGPHNVANALAAAAL 291 Query: 299 XXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVW 358 F+ G HR+ V DG+ Y+DDSKATNPHAA S+LA+P VVW Sbjct: 292 VRAYGVGPEAVAEGLRSFRPGAHRAVEVGEFDGVRYIDDSKATNPHAAIGSLLAHPSVVW 351 Query: 359 VAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSEDADMG 418 +AGG LKGASVD VA +A RL G VL+G D AEAL+RHAPDV V ++ + +D M Sbjct: 352 IAGGQLKGASVDELVAAVAERLRGVVLLGADADVFAEALARHAPDVLVRRIGSGDDEPMT 411 Query: 419 EACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 A A+ GD VLLAPA AS D F Y +RG+ Sbjct: 412 AAVKAA-----------------------RELARPGDAVLLAPAAASLDMFRDYAERGE 447 >sp|Q9S2W9|MURD_STRCO Tax_Id=1902 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Streptomyces coelicolor] Length = 471 Score = 283 bits (725), Expect = 3e-74 Identities = 193/485 (39%), Positives = 242/485 (49%), Gaps = 46/485 (9%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAESGVATVDPSVAVQQLAQP 67 G V VAG V+G L GA T+ +D A + A ++P +L Sbjct: 7 GKHVTVAGLGVSGVPAAKVLHGLGAQVTVVNDGDDER---ARTQAAELEPLGVTVRLGDG 63 Query: 68 EASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYG-PPRRWLVV 126 + PE L+VT+PG++P+ P+ GVP+WGDVELAWRL G G P WL V Sbjct: 64 DTLPEGT-ELIVTAPGWKPTKPLFTAAGQAGVPVWGDVELAWRL--RGLNGRKPAPWLAV 120 Query: 127 XXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--EEPADLLAVELSSFQLHWAP 184 ML ++L A R+ GNIG +LD + E+ D+LAVELSS+QLHWAP Sbjct: 121 TGTNGKTTTVQMLASILKAAGLRTAAVGNIGVSLLDAVTGEQEYDVLAVELSSYQLHWAP 180 Query: 185 SLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGR-------VAVVGLDDSRAAALRD 237 SLR + VLN+A DHLDWHG+M AY K R+ G VA +D AA D Sbjct: 181 SLRAHSAAVLNLAPDHLDWHGSMEAYAADKGRIYEGNHVACVYNVADKATEDLVRAA--D 238 Query: 238 TAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLV-----LLPASSIPVPGPXXXXXX 292 +GF +G P +LG+ +G LVDRAF +D L S + P P Sbjct: 239 VEEGCRAIGFTLGTPGPSQLGVVEGLLVDRAFVEDRQKNAQELAEVSDVNPPAPHNIANA 298 Query: 293 XXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLA 352 F HR V VDG+ YVDDSKATN HA EAS+ A Sbjct: 299 LAAAGLARAFGVSAAAVRDGLRAFTPDAHRIAHVADVDGVAYVDDSKATNTHATEASLAA 358 Query: 353 YPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTS 412 Y +VW+AGGL KGA+ D VA A RL GAVLIG DRA + EAL+RHAP+VPVV + + Sbjct: 359 YESIVWIAGGLAKGATFDELVAGAAKRLRGAVLIGADRALIREALARHAPEVPVVDLDRT 418 Query: 413 EDADMGEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSY 472 + GA + V + GDTVLLAPA AS D FT+Y Sbjct: 419 DT-------GAMLQAVQEA----------------RRLARPGDTVLLAPACASMDMFTNY 455 Query: 473 GDRGD 477 RGD Sbjct: 456 NQRGD 460 >tr|C3PHF8|C3PHF8_CORA7 Tax_Id=548476 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium aurimucosum] Length = 463 Score = 283 bits (724), Expect = 4e-74 Identities = 190/478 (39%), Positives = 247/478 (51%), Gaps = 47/478 (9%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCD-DDPAMLRPFAESGVATVDPSVAVQQLAQPEA 69 VL+AGA V+GR A L+ G T+ D ++ + R AE GVATVD S A Sbjct: 11 VLIAGAGVSGRGCAAVLSSLGVDLTVADGNEDSRSRIAAELGVATVDTS----------A 60 Query: 70 SPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXX 129 + Y+LVVTSPG++P +P+L G+ + GDVELA+RLD A +G PRRWL + Sbjct: 61 VDLAGYSLVVTSPGWRPDSPLLAAAASRGLEVIGDVELAYRLDQAEVFGAPRRWLAITGT 120 Query: 130 XXXXXXXSMLHAMLVAGQHRS----VLCGNIGSPVLDVL--EEPADLLAVELSSFQLHWA 183 ML A++ A + RS GNIG D L E D+L ELSSFQLHW+ Sbjct: 121 NGKTTTTGMLAAIMAADEQRSGQRAQAVGNIGVSSFDALAAEPRVDILVAELSSFQLHWS 180 Query: 184 PSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPV 243 LRPE G +LN+A+DHLDWHG+ AY KA++L G+ AV G +D L A P Sbjct: 181 SHLRPEVGALLNLADDHLDWHGSFEAYAADKAKILRGQHAVYGKEDEHVRVL--AASLPG 238 Query: 244 RVGFRIGAPAVGELGLRDGHLV--DRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXX 301 F PA GE+G+ G L+ + A V+ ++I G Sbjct: 239 ATAFSHAEPAAGEVGVSTGSLLVNEVAGMKSAVVDDVTTIQPAGLAGVLDAAAASAVAAL 298 Query: 302 XXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAG 361 + V HR E+V G+TY+D+SKATNPHAAE ++ VVWVAG Sbjct: 299 AGAQPESIAEGLSAYVVAGHRGEIVHRHAGVTYIDNSKATNPHAAEVAMRGLDSVVWVAG 358 Query: 362 GLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSED--ADMGE 419 G LKGA V + A+RL AVL+G D+ +A+AL + AP VPVV +V S D A M + Sbjct: 359 GQLKGADVSELLRTHAARLKTAVLVGVDKHVLAQALVKAAPHVPVV-IVDSHDPEAAMEQ 417 Query: 420 ACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 A A+V D +GDTVLLAPA AS D +T G RGD Sbjct: 418 AVSAAVQHAD-----------------------AGDTVLLAPAAASLDMYTGMGQRGD 452 >tr|C0E4N1|C0E4N1_9CORY Tax_Id=566549 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium matruchotii ATCC 33806] Length = 472 Score = 283 bits (724), Expect = 4e-74 Identities = 173/479 (36%), Positives = 248/479 (51%), Gaps = 41/479 (8%) Query: 4 PLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCD-DDPAMLRPFAESGVATVDPSVAVQ 62 P + VLV GA ++G + L + D ++ A R + VA + P A+ Sbjct: 12 PEILSGTVLVTGAGISGVGIARLLADLNVDVLIADANETARDRAMEVADVAGIHPDQALA 71 Query: 63 QLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRR 122 +L SR++ VVTSPG++P TP+L G+ + GDVEL +RLD A +GPPR Sbjct: 72 EL--------SRFSCVVTSPGWRPDTPLLRAAQAAGLEVLGDVELCYRLDRASVFGPPRT 123 Query: 123 WLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPA--DLLAVELSSFQL 180 W+VV SML +++ +++ GNIG V + + P D+L ELSSFQL Sbjct: 124 WMVVTGTNGKTTTTSMLASIMQHAGYQAEAVGNIGVSVAEAISAPQRIDVLVAELSSFQL 183 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HW+ L P+ GV+LN+AEDH+DWHG+MAAY AKA+VL +A+ GLDD A ++ Sbjct: 184 HWSSQLVPDVGVLLNLAEDHIDWHGSMAAYAAAKAKVLAAPLAIAGLDD---ALVQQYVT 240 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 PV +GF + P VG++G+ +G +VD ++P + + PGP Sbjct: 241 TPV-MGFTMHPPQVGQVGVTNGTIVDNLHGTPRNIVPVAGLEPPGPAGIYDALAATAAAV 299 Query: 301 XXXXXXXXXXXXXXX--FQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVW 358 F+V HR + V GI +D+SKATNPHAA++++ + V+W Sbjct: 300 ALVPDLQPSVIAQALQSFKVAGHRGQQVAEARGIVAIDNSKATNPHAADSALAGHDSVIW 359 Query: 359 VAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPV-VQVVTSEDADM 417 VAGG LKGA VD +AR A RL L+G DR + E++ +HAP VP+ V T + M Sbjct: 360 VAGGQLKGAEVDDLIARHAHRLKAVALMGVDRNIIRESVEKHAPGVPIFVTDDTDPQSAM 419 Query: 418 GEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRG 476 C +VT+ SGD ++LAPA AS D +T G RG Sbjct: 420 DAVCAWAVTQAS-----------------------SGDAIVLAPAAASLDMYTGMGQRG 455 >sp|Q6NGC6|MURD_CORDI Tax_Id=1717 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; AltName: Full=D-glutamic acid-adding enzyme;[Corynebacterium diphtheriae] Length = 475 Score = 282 bits (721), Expect = 8e-74 Identities = 168/475 (35%), Positives = 243/475 (51%), Gaps = 38/475 (8%) Query: 11 VLVAGARVTGRAVLAALTRFGAIPTMCDDDPAMLRPFAE-SGVATVDPSVAVQQLAQPEA 69 VLVAGA V+G + L G T+ D + A L A+ +G T+ P+ V Q Sbjct: 19 VLVAGAGVSGVGITQLLREMGCAVTVADSNSAQLDKLAQQTGCQTISPADVVSDGFQD-- 76 Query: 70 SPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXX 129 Y +VVTSPG++P +P+L G+ + GDVEL +RLD A +GP R W+VV Sbjct: 77 -----YTVVVTSPGWRPDSPLLVAAQSAGLEVIGDVELVYRLDRAEVFGPKRTWMVVTGT 131 Query: 130 XXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--EEPADLLAVELSSFQLHWAPSLR 187 +ML ++ R+ GNIG V D + + D+L ELSSFQLHW+ +L Sbjct: 132 NGKTTTTAMLAEIMQHSGARAAAVGNIGVSVADAVRTQPRIDVLVAELSSFQLHWSSTLV 191 Query: 188 PEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDD----SRAAALRDTAPAPV 243 P+ G++LN+A+DH+DWHG+ A Y + KA+VL A+ G D+ + ++ A Sbjct: 192 PDVGILLNLADDHIDWHGSFAQYAQDKAKVLAAPTAIAGFDNGHVMTETTRIQRAEDADP 251 Query: 244 RVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXX 303 +GF +G PA G +G+RDG L+D AF D++VL A I GP Sbjct: 252 IIGFTLGEPAKGMVGVRDGQLIDCAFGDNVVLRSAEGIEPAGPAGLNDALAAAAAARSMG 311 Query: 304 XXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGL 363 F+V HR + V + +D+SKATNPHAA++++ + VVWVAGG Sbjct: 312 VSAVCIEEALSKFEVAGHRGQCVGRHREVVAIDNSKATNPHAADSALAGFSSVVWVAGGQ 371 Query: 364 LKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQV-VTSEDADMGEACG 422 LKGA +D + R A R+ L+G DR + +++ H P +PV+ V T M EA Sbjct: 372 LKGAEIDELIVRHAGRIKAVALLGVDRDVIEDSVRTHIPGIPVLSVSETDPRRAMDEAVA 431 Query: 423 ASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 SV++ + +GD ++LAPA AS D +T G RGD Sbjct: 432 WSVSQAE-----------------------AGDAIVLAPAAASLDMYTGMGQRGD 463 >tr|C5VD79|C5VD79_9CORY Tax_Id=553207 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium matruchotii ATCC 14266] Length = 472 Score = 280 bits (716), Expect = 3e-73 Identities = 172/479 (35%), Positives = 246/479 (51%), Gaps = 41/479 (8%) Query: 4 PLVPGAPVLVAGARVTGRAVLAALTRFGAIPTMCD-DDPAMLRPFAESGVATVDPSVAVQ 62 P + VLV GA ++G + L + D ++ A R + VA + P A+ Sbjct: 12 PEILSGTVLVTGAGISGVGIARLLADLNVDVLIADTNETARDRAMEVADVAGIHPDQALA 71 Query: 63 QLAQPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRR 122 +L SR++ VVTSPG++P TP+L G+ + GDVEL +RLD A +GPPR Sbjct: 72 EL--------SRFSCVVTSPGWRPDTPLLRAAQAAGLEVLGDVELCYRLDRASVFGPPRT 123 Query: 123 WLVVXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVLEEPA--DLLAVELSSFQL 180 W+VV SML +++ +++ GNIG V + + P D+L ELSSFQL Sbjct: 124 WMVVTGTNGKTTTTSMLASIMQHAGYQAEAVGNIGVSVAEAISAPQRIDVLVAELSSFQL 183 Query: 181 HWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAP 240 HW+ L P+ GV+LN+AEDH+DWHG+MAAY AKA+VL +A+ GLDD A ++ Sbjct: 184 HWSSQLVPDVGVLLNLAEDHIDWHGSMAAYAAAKAKVLAAPLAIAGLDD---ALVQQYVT 240 Query: 241 APVRVGFRIGAPAVGELGLRDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXX 300 PV +GF + P G++G+ +G +VD ++P + + PGP Sbjct: 241 TPV-MGFTMHPPQAGQVGVTNGTIVDNLHGTTRNIVPVAGLEPPGPAGIYDALAATAAAV 299 Query: 301 XXXXXXXXXXXXXXX--FQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVW 358 F+V HR + V GI +D+SKATNPHAA++++ + V+W Sbjct: 300 ALVPDLQPSVIAQALQSFKVAGHRGQQVAEARGIVAIDNSKATNPHAADSALAGHDSVIW 359 Query: 359 VAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPV-VQVVTSEDADM 417 VAGG LKGA VD VA A RL L+G DR + E++ +HAP VP+ V T + M Sbjct: 360 VAGGQLKGAEVDDLVAHHAHRLKAVALMGVDRNIIRESVEKHAPGVPIFVTDDTDPQSAM 419 Query: 418 GEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRG 476 C +VT+ SGD ++LAPA AS D +T G RG Sbjct: 420 DAVCAWAVTQAS-----------------------SGDAIVLAPAAASLDMYTGMGQRG 455 >tr|C2BNI7|C2BNI7_9CORY Tax_Id=525264 (murD)RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Corynebacterium pseudogenitalium ATCC 33035] Length = 437 Score = 280 bits (716), Expect = 3e-73 Identities = 184/459 (40%), Positives = 231/459 (50%), Gaps = 43/459 (9%) Query: 27 LTRFGAIPTMCDDDPAMLRPFAES-GVATVDPSVAVQQLAQPEASPESRYALVVTSPGFQ 85 L G T+ D + L AE GVATV A Q + LVVTSPG++ Sbjct: 2 LASLGVDTTVADSNETALAELAEEFGVATVSVDSAAQ----------GDFDLVVTSPGWR 51 Query: 86 PSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLVVXXXXXXXXXXSMLHAMLVA 145 P +P+L GV + GDVELA+RLD AG +G PR WLVV ML ++ A Sbjct: 52 PDSPLLVAFQDAGVEVIGDVELAYRLDRAGVFGAPRTWLVVTGTNGKTTTTGMLAQIMQA 111 Query: 146 GQHRS----VLCGNIGSPVLDVLEEPA--DLLAVELSSFQLHWAPSLRPEAGVVLNIAED 199 R+ + GNIG + D L D+L ELSSFQLHW+ LRP+ GV+LN+A+D Sbjct: 112 DAKRTGKRALAVGNIGVSLFDALTATPRLDVLCAELSSFQLHWSSHLRPDVGVLLNLADD 171 Query: 200 HLDWHGTMAAYTEAKARVLTGRVAVVGLDDSRAAALRDTAPAPVRVGFRIGAPAVGELGL 259 HLDWHG+ AY AKA+VL+G VAVVG DD A A+R A GF P GE+G+ Sbjct: 172 HLDWHGSFDAYARAKAKVLSGDVAVVGKDD--AEAVRYAADTADLYGFTAAEPTQGEVGV 229 Query: 260 RDGHLVDRAFSDDLVLLPASSIPVPGPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFQVG 319 G LV R L A I G + V Sbjct: 230 SAGRLVSRLNEQREDLASAEGIEPAGLAGVLDAAAAASVARLAGATPESIAQGLAAYTVA 289 Query: 320 RHRSEVVEVVDGITYVDDSKATNPHAAEASVLAYPRVVWVAGGLLKGASVDAEVARMASR 379 HR VV GIT++D+SKATNPHAA+A++ V+W+AGG LKGA VD VA+ A+ Sbjct: 290 GHRGAVVHEHSGITFIDNSKATNPHAADAALKGLNSVIWIAGGQLKGAEVDGLVAKHAAH 349 Query: 380 LVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSED-ADMGEACGASVTKVDDVGGSLGXX 438 + AV++G DR EVA AL+ HAP PV + T E A M A A++ D Sbjct: 350 IKAAVVLGVDREEVARALAAHAPHAPVDVIETQEPVAAMHAAVEAALQHAD--------- 400 Query: 439 XXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYGDRGD 477 +GDTVLLAPA AS D +T RGD Sbjct: 401 --------------AGDTVLLAPAAASLDMYTGMAQRGD 425 >tr|C7QI97|C7QI97_CATAD Tax_Id=479433 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Catenulispora acidiphila] Length = 494 Score = 278 bits (712), Expect = 9e-73 Identities = 196/491 (39%), Positives = 230/491 (46%), Gaps = 46/491 (9%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCD--DDPAMLRPFAESGVATVDPSVAVQQLA 65 GA V V GARV G + AAL GA T+ D DD A A AV +L Sbjct: 14 GAVVTVVGARVVGLSASAALLARGARVTLIDRYDDAA-----TAGRAAGAAAQGAVVRLG 68 Query: 66 QPEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRRWLV 125 PE LVVT PG PS P++ GVPIWGD ELAWRL A G WLV Sbjct: 69 DDATLPEGTELLVVT-PGLPPSAPIVAAARAAGVPIWGDAELAWRLRAPLADGSYAPWLV 127 Query: 126 VXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL---------EEPADLLAVELS 176 V M AML CGNIG PVLD + EP ++L +ELS Sbjct: 128 VTGTNGKSTTVRMAEAMLKQAGKGVAACGNIGYPVLDAVLRGQAGGEAGEPFEVLVIELS 187 Query: 177 SFQLHWAPSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTG-RVAVV----GLDDSR 231 S+QL+W+ +L P A VLNIA DH+DWHG+ A Y AK R +VA V L+ R Sbjct: 188 SYQLYWSSTLSPLASAVLNIAPDHIDWHGSYADYVAAKGRAYENCQVAAVYNAADLETVR 247 Query: 232 AAALRDTAPAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDD-----LVLLPASSIPVPGP 286 D +GF +GAP + LG+ DG L DRAF D L + P Sbjct: 248 LVEEADVVEGCRAIGFTLGAPGLSMLGVVDGILADRAFIADRRTNAAELGTVYDVEPNAP 307 Query: 287 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAA 346 F+ HR V +DG+ +VDDSKATNPHAA Sbjct: 308 HNIANALAAAALVRAYGVEPAAVRDGLREFRPEPHRIAWVATIDGVDFVDDSKATNPHAA 367 Query: 347 EASVLAYPRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPV 406 AS+ AY VVW+AGGL KGA D V R A RL GAVL G +R VAEAL R AP+VPV Sbjct: 368 SASIGAYDHVVWLAGGLAKGADFDDLVERHAKRLRGAVLFGAERHLVAEALRRRAPEVPV 427 Query: 407 VQVVTSEDADMGEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASF 466 V + E ++ + SGDTVLLAPA AS Sbjct: 428 VDLGGPGPEQAAEVIAEAIAAARTMA-------------------VSGDTVLLAPACASM 468 Query: 467 DQFTSYGDRGD 477 D FTSYG RGD Sbjct: 469 DMFTSYGQRGD 479 >tr|B5I4L0|B5I4L0_9ACTO Tax_Id=463191 RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;[Streptomyces sviceus ATCC 29083] Length = 472 Score = 278 bits (710), Expect = 1e-72 Identities = 195/484 (40%), Positives = 243/484 (50%), Gaps = 47/484 (9%) Query: 8 GAPVLVAGARVTGRAVLAALTRFGAIPTMCDD-DPAMLRPFAESGVATVDPSVAVQQLAQ 66 G V VAG V+G AL GA T+ +D D A R A A ++ +L Sbjct: 11 GKHVTVAGLGVSGIPAAKALHARGAHVTVVNDGDDARAREQA----AELEALGITVRLGD 66 Query: 67 PEASPESRYALVVTSPGFQPSTPVLXXXXXXGVPIWGDVELAWRLDAAGCYGPPRR-WLV 125 PE LVVT+PG++P P+ G+ IWGDVELAWRL GP WL Sbjct: 67 GATLPEGT-ELVVTAPGWKPDKPLFTAARAAGLEIWGDVELAWRLR-----GPDAAPWLA 120 Query: 126 VXXXXXXXXXXSMLHAMLVAGQHRSVLCGNIGSPVLDVL--EEPADLLAVELSSFQLHWA 183 + ML ++L A R+ GNIG +LD + +E D+LAVELSS+QLHWA Sbjct: 121 ITGTNGKTTTTQMLASILKAAGLRTAAVGNIGVSLLDAVLGDEQYDVLAVELSSYQLHWA 180 Query: 184 PSLRPEAGVVLNIAEDHLDWHGTMAAYTEAKARVLTG-RVAVV-GLDDSRAAAL---RDT 238 PSLR + VLN+A DHLDWHG+M AY K R+ G RVA V + D L D Sbjct: 181 PSLRAHSAAVLNLAPDHLDWHGSMEAYAADKGRIYEGNRVACVYNVADKATEDLVREADV 240 Query: 239 APAPVRVGFRIGAPAVGELGLRDGHLVDRAFSDDL-----VLLPASSIPVPGPXXXXXXX 293 +GF +G P +LG+ +G LVDRAF +D L S + P P Sbjct: 241 EEGCRAIGFTLGTPGPSQLGVVEGILVDRAFVEDRHKNAQELAEVSDVNPPAPHNIANAL 300 Query: 294 XXXXXXXXXXXXXXXXXXXXXXFQVGRHRSEVVEVVDGITYVDDSKATNPHAAEASVLAY 353 F HR V VDG+ YVDDSKATN HAAEAS+ AY Sbjct: 301 AAAALARAFGVPARAVRDGLRDFTPDAHRISHVADVDGVGYVDDSKATNTHAAEASLAAY 360 Query: 354 PRVVWVAGGLLKGASVDAEVARMASRLVGAVLIGQDRAEVAEALSRHAPDVPVVQVVTSE 413 +VW+AGGL KGA+ D VA+ A RL G VLIGQDRA + EAL+RHAP+VPVV + ++ Sbjct: 361 ESIVWIAGGLAKGATFDELVAKSAKRLRGVVLIGQDRALIREALARHAPEVPVVDLDRTD 420 Query: 414 DADMGEACGASVTKVDDVGGSLGXXXXXXXXXXXXXXXXSGDTVLLAPAGASFDQFTSYG 473 GA + V + +GDTVLLAPA AS D F +Y Sbjct: 421 -------TGAMLAAVQEAS----------------RLAVAGDTVLLAPACASMDMFANYN 457 Query: 474 DRGD 477 RGD Sbjct: 458 KRGD 461 Database: Amellifera_nr Posted date: Feb 5, 2010 5:10 AM Number of letters in database: 3,846,993,858 Number of sequences in database: 11,275,203 Lambda K H 0.318 0.135 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11275203 Number of Hits to DB: 3,163,810,932 Number of extensions: 119363530 Number of successful extensions: 327314 Number of sequences better than 10.0: 2955 Number of HSP's gapped: 325586 Number of HSP's successfully gapped: 3992 Length of query: 488 Length of database: 3,846,993,858 Length adjustment: 142 Effective length of query: 346 Effective length of database: 2,245,915,032 Effective search space: 777086601072 Effective search space used: 777086601072 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 82 (36.2 bits)