BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MMAR_3691 (1670 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,275,203 sequences; 3,846,993,858 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|B2HM87|B2HM87_MYCMM Tax_Id=216594 (mbtE)SubName: Full=Non-rib... 2999 0.0 tr|A0PTU8|A0PTU8_MYCUA Tax_Id=362242 (mbtE)SubName: Full=Non-rib... 2979 0.0 tr|Q5Z1T0|Q5Z1T0_NOCFA Tax_Id=37329 (nbtD)SubName: Full=Putative... 1894 0.0 tr|B1MPF2|B1MPF2_MYCA9 Tax_Id=561007 SubName: Full=Putative pept... 1738 0.0 tr|D0L265|D0L265_GORB4 Tax_Id=526226 SubName: Full=Amino acid ad... 1395 0.0 tr|C1B2F0|C1B2F0_RHOOB Tax_Id=632772 SubName: Full=Non-ribosomal... 1202 0.0 tr|A0R0U5|A0R0U5_MYCS2 Tax_Id=246196 SubName: Full=Linear gramic... 1096 0.0 tr|A0QE94|A0QE94_MYCA1 Tax_Id=243243 SubName: Full=Linear gramic... 1076 0.0 tr|Q73XY5|Q73XY5_MYCPA Tax_Id=1770 (mbtE)SubName: Full=MbtE;[Myc... 1070 0.0 tr|C6DNA4|C6DNA4_MYCTK Tax_Id=478434 SubName: Full=Peptide synth... 1068 0.0 tr|Q7D791|Q7D791_MYCTU Tax_Id=1773 SubName: Full=Peptide synthet... 1068 0.0 tr|A5WPZ5|A5WPZ5_MYCTF Tax_Id=336982 SubName: Full=Peptide synth... 1068 0.0 tr|A4KJD0|A4KJD0_MYCTU Tax_Id=395095 SubName: Full=Peptide synth... 1068 0.0 tr|A2VKA6|A2VKA6_MYCTU Tax_Id=348776 SubName: Full=Peptide synth... 1068 0.0 tr|A4T2D0|A4T2D0_MYCGI Tax_Id=350054 SubName: Full=Amino acid ad... 1067 0.0 tr|A1TBS6|A1TBS6_MYCVP Tax_Id=350058 SubName: Full=Amino acid ad... 1061 0.0 tr|Q7TYQ7|Q7TYQ7_MYCBO Tax_Id=1765 (mbtE)SubName: Full=PEPTIDE S... 1053 0.0 tr|O86329|O86329_MYCTU Tax_Id=1773 (mbtE)SubName: Full=PEPTIDE S... 1053 0.0 tr|C1AQU3|C1AQU3_MYCBT Tax_Id=561275 (mbtE)SubName: Full=Peptide... 1053 0.0 tr|A5U573|A5U573_MYCTA Tax_Id=419947 (mbtE)SubName: Full=Peptide... 1053 0.0 tr|A1KL70|A1KL70_MYCBP Tax_Id=410289 (mbtE)SubName: Full=Peptide... 1053 0.0 tr|Q1B6B1|Q1B6B1_MYCSS Tax_Id=164756 SubName: Full=Amino acid ad... 1032 0.0 tr|A1UIR5|A1UIR5_MYCSK Tax_Id=189918 SubName: Full=Amino acid ad... 1032 0.0 tr|A3Q278|A3Q278_MYCSJ Tax_Id=164757 SubName: Full=Amino acid ad... 1030 0.0 tr|C2AVD0|C2AVD0_TSUPA Tax_Id=521096 SubName: Full=Amino acid ad... 923 0.0 tr|Q5YPH6|Q5YPH6_NOCFA Tax_Id=37329 SubName: Full=Putative non-r... 824 0.0 tr|A3KFG5|A3KFG5_9ACTO Tax_Id=196914 (pstC)SubName: Full=PstC pr... 819 0.0 tr|C1AR31|C1AR31_RHOOB Tax_Id=632772 SubName: Full=Putative non-... 805 0.0 tr|C7MU85|C7MU85_SACVD Tax_Id=471857 SubName: Full=Non-ribosomal... 805 0.0 tr|O07944|O07944_STRPR Tax_Id=38300 (snbDE)SubName: Full=Pristin... 801 0.0 tr|D0RB84|D0RB84_STRPR Tax_Id=38300 (snbDE)SubName: Full=Putativ... 800 0.0 tr|C6WBS4|C6WBS4_ACTMD Tax_Id=446462 SubName: Full=Cyclic nucleo... 798 0.0 tr|Q5YPH7|Q5YPH7_NOCFA Tax_Id=37329 SubName: Full=Putative non-r... 791 0.0 tr|Q0SKF6|Q0SKF6_RHOSR Tax_Id=101510 SubName: Full=Non-ribosomal... 789 0.0 tr|C1AZY4|C1AZY4_RHOOB Tax_Id=632772 SubName: Full=Putative non-... 789 0.0 tr|Q2JA66|Q2JA66_FRASC Tax_Id=106370 SubName: Full=Amino acid ad... 788 0.0 tr|D1A2F2|D1A2F2_THECU Tax_Id=471852 SubName: Full=Amino acid ad... 788 0.0 tr|Q45R85|Q45R85_STRFR Tax_Id=1906 (lptA)SubName: Full=Peptide s... 787 0.0 tr|Q9Z4X5|Q9Z4X5_STRCO Tax_Id=1902 (cdaPS2)SubName: Full=CDA pep... 784 0.0 tr|A8M6W3|A8M6W3_SALAI Tax_Id=391037 SubName: Full=Amino acid ad... 781 0.0 tr|A4FHN2|A4FHN2_SACEN Tax_Id=405948 SubName: Full=Putative non-... 779 0.0 tr|Q5YPK6|Q5YPK6_NOCFA Tax_Id=37329 SubName: Full=Putative non-r... 776 0.0 tr|Q0S5D8|Q0S5D8_RHOSR Tax_Id=101510 SubName: Full=Non-ribosomal... 768 0.0 tr|Q1D6A0|Q1D6A0_MYXXD Tax_Id=246197 SubName: Full=Non-ribosomal... 765 0.0 tr|Q0S3K6|Q0S3K6_RHOSR Tax_Id=101510 SubName: Full=Non-ribosomal... 763 0.0 tr|Q5Z1X7|Q5Z1X7_NOCFA Tax_Id=37329 SubName: Full=Putative non-r... 762 0.0 tr|Q50E74|Q50E74_STRFL Tax_Id=67294 (dptA)SubName: Full=Peptide ... 761 0.0 tr|B1MAQ8|B1MAQ8_MYCA9 Tax_Id=561007 SubName: Full=Probable pept... 761 0.0 tr|C3JNH4|C3JNH4_RHOER Tax_Id=596309 SubName: Full=Amino acid ad... 759 0.0 tr|Q5Z1X9|Q5Z1X9_NOCFA Tax_Id=37329 SubName: Full=Putative non-r... 758 0.0 >tr|B2HM87|B2HM87_MYCMM Tax_Id=216594 (mbtE)SubName: Full=Non-ribosomal peptide synthetase MbtE;[Mycobacterium marinum] Length = 1670 Score = 2999 bits (7775), Expect = 0.0 Identities = 1542/1670 (92%), Positives = 1542/1670 (92%) Query: 1 MADDVXXXXXXXXXXXXXXIAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPD 60 MADDV IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPD Sbjct: 1 MADDVRTLQDRRRELLRRRIAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPD 60 Query: 61 DVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR 120 DVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR Sbjct: 61 DVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR 120 Query: 121 REDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWD 180 REDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWD Sbjct: 121 REDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWD 180 Query: 181 DDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXX 240 DDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLR Sbjct: 181 DDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRPLPEPPEL 240 Query: 241 XGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFL 300 GVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFL Sbjct: 241 PGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFL 300 Query: 301 VSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV 360 VSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV Sbjct: 301 VSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV 360 Query: 361 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDP 420 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDP Sbjct: 361 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDP 420 Query: 421 DDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG 480 DDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG Sbjct: 421 DDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG 480 Query: 481 ELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPE 540 ELVEMPATTMVK VSDEAELTYSELHRRANRLARWFIGQGFGPE Sbjct: 481 ELVEMPATTMVKLLEATASAAGTATALALVSDEAELTYSELHRRANRLARWFIGQGFGPE 540 Query: 541 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVA 600 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVA Sbjct: 541 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVA 600 Query: 601 ERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW 660 ERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW Sbjct: 601 ERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW 660 Query: 661 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXX 720 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTV Sbjct: 661 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVLH 720 Query: 721 XXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS 780 QWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS Sbjct: 721 LVPSMLSTLLLLPQVQQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS 780 Query: 781 THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTL 840 THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTL Sbjct: 781 THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTL 840 Query: 841 TAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 TAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH Sbjct: 841 TAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 Query: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM Sbjct: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 Query: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL 1020 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL Sbjct: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL 1020 Query: 1021 LAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK 1080 LAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK Sbjct: 1021 LAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK 1080 Query: 1081 RARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXX 1140 RARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGP Sbjct: 1081 RARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPLDSVALAAALND 1140 Query: 1141 XXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL 1200 RHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL Sbjct: 1141 VVARHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL 1200 Query: 1201 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD 1260 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD Sbjct: 1201 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD 1260 Query: 1261 YAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARR 1320 YAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARR Sbjct: 1261 YAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARR 1320 Query: 1321 AALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVV 1380 AALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVV Sbjct: 1321 AALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVV 1380 Query: 1381 VLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 VLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR Sbjct: 1381 VLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 Query: 1441 GEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEPXX 1500 GEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEP Sbjct: 1441 GEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEPAT 1500 Query: 1501 XXXXXXXXXXXXXXXXXXXXXXXSAVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXETE 1560 SAVQ ETE Sbjct: 1501 VALIADALDAALAAFATTPDLPLSAVQLLPSADLAKLLAPPLPAGPAASPPVAAGSAETE 1560 Query: 1561 RRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAEL 1620 RRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAEL Sbjct: 1561 RRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAEL 1620 Query: 1621 AAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS 1670 AAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS Sbjct: 1621 AAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS 1670 >tr|A0PTU8|A0PTU8_MYCUA Tax_Id=362242 (mbtE)SubName: Full=Non-ribosomal peptide synthetase MbtE;[Mycobacterium ulcerans] Length = 1670 Score = 2979 bits (7723), Expect = 0.0 Identities = 1529/1670 (91%), Positives = 1536/1670 (91%) Query: 1 MADDVXXXXXXXXXXXXXXIAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPD 60 MADDV IAESGLAAEQSSDQP ICPGERYRLSDGQRRMWFLQTMDPD Sbjct: 1 MADDVRTLQDRRRELLRRRIAESGLAAEQSSDQPRICPGERYRLSDGQRRMWFLQTMDPD 60 Query: 61 DVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR 120 DVTLNICVAYRL GLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR Sbjct: 61 DVTLNICVAYRLTGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR 120 Query: 121 REDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWD 180 REDLTRLPEAGHE+QIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWD Sbjct: 121 REDLTRLPEAGHEQQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWD 180 Query: 181 DDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXX 240 DDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLR Sbjct: 181 DDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRPLPEPPEL 240 Query: 241 XGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFL 300 GVSGANPCRRAQRRVRPLPAGLFSRVE+FARKCSASPFMVLLAAYGVLVRRYTGASDFL Sbjct: 241 PGVSGANPCRRAQRRVRPLPAGLFSRVEEFARKCSASPFMVLLAAYGVLVRRYTGASDFL 300 Query: 301 VSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV 360 VSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV Sbjct: 301 VSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV 360 Query: 361 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDP 420 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGA+AAHLPLSLTIALDP Sbjct: 361 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAIAAHLPLSLTIALDP 420 Query: 421 DDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG 480 DDVSVEFEYQQQLSSVLVDQML HYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG Sbjct: 421 DDVSVEFEYQQQLSSVLVDQMLAHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG 480 Query: 481 ELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPE 540 ELVEMPATTMVK VSDEAELTYSELHRRANRLARWFIGQGFGPE Sbjct: 481 ELVEMPATTMVKLLEATASAAGTATALALVSDEAELTYSELHRRANRLARWFIGQGFGPE 540 Query: 541 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVA 600 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVA Sbjct: 541 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVA 600 Query: 601 ERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW 660 ERAAADNSDLPLSD DRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW Sbjct: 601 ERAAADNSDLPLSDGDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW 660 Query: 661 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXX 720 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTV Sbjct: 661 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVLH 720 Query: 721 XXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS 780 QWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS Sbjct: 721 LVPSMLSTLLLLPQVQQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS 780 Query: 781 THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTL 840 THM+VTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQV+GELYLGGSQLARGYLGRPTL Sbjct: 781 THMLVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVVGELYLGGSQLARGYLGRPTL 840 Query: 841 TAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 TAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH Sbjct: 841 TAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 Query: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM Sbjct: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 Query: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL 1020 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL Sbjct: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL 1020 Query: 1021 LAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK 1080 LAARLVAQIRAEFGVDLTVRTIFD PTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK Sbjct: 1021 LAARLVAQIRAEFGVDLTVRTIFDVPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK 1080 Query: 1081 RARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXX 1140 +ARPGFVKSARPQ LPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGP Sbjct: 1081 QARPGFVKSARPQWLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPLDSVALAAALND 1140 Query: 1141 XXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL 1200 RHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL Sbjct: 1141 VVARHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL 1200 Query: 1201 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD 1260 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD Sbjct: 1201 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD 1260 Query: 1261 YAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARR 1320 YAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARR Sbjct: 1261 YAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARR 1320 Query: 1321 AALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVV 1380 +ALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVV Sbjct: 1321 SALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVV 1380 Query: 1381 VLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 VLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR Sbjct: 1381 VLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 Query: 1441 GEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEPXX 1500 GEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEP Sbjct: 1441 GEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEPAT 1500 Query: 1501 XXXXXXXXXXXXXXXXXXXXXXXSAVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXETE 1560 SAVQ ETE Sbjct: 1501 VALIADALDAALAAFATTPDLPLSAVQLLPRADLAKLLAPPLPAGPAASQPVAAGSAETE 1560 Query: 1561 RRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAEL 1620 RRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAEL Sbjct: 1561 RRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAEL 1620 Query: 1621 AAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS 1670 AAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS Sbjct: 1621 AAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS 1670 >tr|Q5Z1T0|Q5Z1T0_NOCFA Tax_Id=37329 (nbtD)SubName: Full=Putative non-ribosomal peptide synthetase;[Nocardia farcinica] Length = 1701 Score = 1894 bits (4906), Expect = 0.0 Identities = 1004/1681 (59%), Positives = 1193/1681 (70%), Gaps = 37/1681 (2%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 + ESGLA +S Q GERY LS GQRRMWFLQT D D TLNIC+AYRL G +DE Sbjct: 23 LRESGLATAESDAQRAQA-GERYPLSPGQRRMWFLQTRDAADTTLNICLAYRLTGALDEQ 81 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RL A VVARH +LRTTYGVD +GEPYQVF+DDV + W+ DLT LPE G R++E L Sbjct: 82 RLREAFGTVVARHDLLRTTYGVDEQGEPYQVFTDDVVLAWQSHDLTDLPEQGRARRVEVL 141 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EFGRPFDL E PLR T++RT A+E VL+LVVHHI +DD+SW VFF E++AAYN Sbjct: 142 ARREFGRPFDLAAETPLRATLVRTGAEEHVLVLVVHHIAFDDESWPVFFAEVNAAYNGAE 201 Query: 200 INDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPL 259 AQF++ EVL P+ ADV YW +LR G + + P +A+RR L Sbjct: 202 PGAAPAQFVAAEVLAGPDEPAEADVEYWRASLRPLPEPLELPGSAPSQPSTQAERRTLAL 261 Query: 260 PAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYF 319 PA L +RV+ FAR+ SA+PFMVLLAA+ LV RYT A+DFLVSVPVT R A G +GYF Sbjct: 262 PADLMTRVDAFARERSATPFMVLLAAFDALVHRYTAATDFLVSVPVTNRRAATEGLIGYF 321 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM-GRDGMDLLV 378 GNTLLLR R D+FT V RETCL GFAHQSVGIDRVVREANPER+ GRDGMD LV Sbjct: 322 GNTLLLRAAVRPHDSFTGLVEATRETCLNGFAHQSVGIDRVVREANPERVAGRDGMDQLV 381 Query: 379 RLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVL 437 RLGF++RK + AL GV +QL LGA A +PL+L + L+ +E EYQ LS+ L Sbjct: 382 RLGFSVRKGSDAFALRGVTAQQLELGAPTAQVPLALAVVLESTGALLELEYQTDVLSAEL 441 Query: 438 VDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXX 497 V+Q+L HYL L+D AL EP R L+ L +L +R +VL QSHGELV PATTMV Sbjct: 442 VEQLLRHYLHLLDSALREPTRRLADLAMLSPEDRAAVLEQSHGELVPAPATTMV--ALLE 499 Query: 498 XXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAM 557 VSD+ ELTY +LHRRANR+AR I +G G EDI+GLRM S+EF+VAM Sbjct: 500 RAAAQRPGDLALVSDDTELTYDQLHRRANRVARLLIAEGIGTEDIVGLRMTTSVEFVVAM 559 Query: 558 LAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDR 617 LAVLK+GAAYLPIDPAYP++RI+YL+ DA P V+G E AE AAAD D +D+DR Sbjct: 560 LAVLKSGAAYLPIDPAYPEDRIEYLVEDAEPALVLGPVEFAAAESAAADLPDTAPTDADR 619 Query: 618 LRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFD 677 +RPL PG+LAYVIYTSGSTG+PKGV V H AIAEHV+ F AEW MTAEDR LQ SSVSFD Sbjct: 620 VRPLLPGNLAYVIYTSGSTGKPKGVPVPHAAIAEHVESFTAEWGMTAEDRLLQSSSVSFD 679 Query: 678 ASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQ 737 ASL D+FVTL LGA+LIVPKPDAF DI+YVADLI+RRGVTV + Sbjct: 680 ASLLDLFVTLSLGARLIVPKPDAFRDIAYVADLITRRGVTVLHMVPSMLSTFLLLPEVSE 739 Query: 738 WRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIG 797 WR LRHVPVGGEALPGEVAD+FAG FDAELRNHYGPTEAVVCSTHM V G G VVPIG Sbjct: 740 WRALRHVPVGGEALPGEVADKFAGVFDAELRNHYGPTEAVVCSTHMPVEGPQGTGVVPIG 799 Query: 798 VPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLY 857 VPNRNVY YVLDE L VP V+GELYLGG QLARGYLGRP LTAQRF+ADPF PG RLY Sbjct: 800 VPNRNVYTYVLDEALQLVPAGVVGELYLGGDQLARGYLGRPELTAQRFVADPFTPGARLY 859 Query: 858 RTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHC-LVVAEETEAG 916 RTGDLVRRNH GELEFVGRADEQVK+RGFRIELGEVE+ + THPAV HC +VVAE+ G Sbjct: 860 RTGDLVRRNHFGELEFVGRADEQVKVRGFRIELGEVEAAVATHPAVGHCVVVVAEDPAVG 919 Query: 917 PMLAAYLVPAA-----AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRAL 971 PMLAAY+VPAA ++DLEE+RAH AA +P+YMVP AFAVIPEIP+TV+GKLD+RAL Sbjct: 920 PMLAAYVVPAADEIAGGEIDLEEVRAHAAAVLPQYMVPSAFAVIPEIPLTVNGKLDKRAL 979 Query: 972 PAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRA 1031 PAPTP R +REP TATER +C+IF LF +RVGA+DSFF LGGHSLLAARLVAQIRA Sbjct: 980 PAPTPAVERSFREPATATERRLCAIFGHLFKMERVGADDSFFELGGHSLLAARLVAQIRA 1039 Query: 1032 EFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAAD------------------ 1073 EFG++L VR IFD PT AGLAARLV RFR++F++DLD++ AD Sbjct: 1040 EFGIELDVRAIFDTPTAAGLAARLVARFRDEFDIDLDSMDADFDGADTEFVGADIDFVEA 1099 Query: 1074 DMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXX 1133 + L ARP V + RP+R+PLS+SQLA WFQYR+EGA N+P A+R +G Sbjct: 1100 EGALPGGSARPPLVAAERPERIPLSYSQLAMWFQYRMEGATVAGNLPFAMRIDGDLDTTA 1159 Query: 1134 XXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVF 1193 RHEALRTNF EH+GVPYQ+VHPS ++L V A ++ D +LR ++F Sbjct: 1160 LSAALNDIVARHEALRTNFPEHDGVPYQLVHPSLEIELPVLATSEENLDATLDELRGYLF 1219 Query: 1194 TPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDI 1253 + E+ PL++ LLVLGP THVL L+VHHIV+DHASL I DDLI AYRAR+ +AP+W Sbjct: 1220 SVETEPLIRPTLLVLGPRTHVLSLLVHHIVADHASLGIFLDDLITAYRARVAGSAPRWAA 1279 Query: 1254 LPIQFADYAVWQRNTFE-------SNWGQTELDYWRDALAGLPDEISVATDRARPRVLGK 1306 IQ+ADYA+WQR F+ S + + E+++WR LAGLPDEISVA DR RP VLGK Sbjct: 1280 PAIQYADYALWQRAAFDHEPAGAPSEFARAEIEHWRGVLAGLPDEISVAPDRPRPPVLGK 1339 Query: 1307 RGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVE 1366 RGEVV F VPAA RAAL LA+++G +EFMLYQAA+A +LH LGGGTDIA+G+PVAARVE Sbjct: 1340 RGEVVTFVVPAAERAALEDLAKQSGVSEFMLYQAAVATLLHTLGGGTDIAVGTPVAARVE 1399 Query: 1367 PATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRA 1426 PA LVGLFAN+VVLR DL+GDPTLR+++ SRD VLDA AHQELPIERLVEALNPPR+ Sbjct: 1400 PAVGALVGLFANMVVLRNDLAGDPTLRTVIARSRDVVLDAHAHQELPIERLVEALNPPRS 1459 Query: 1427 LSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELD 1486 SRNPLFQ+M++FRG DWA P L+ G+TT+ LP +F+++ L L + ++V G L+ Sbjct: 1460 RSRNPLFQSMIHFRGADWAPAPTALSESGDTTLTVLPTDFDISFLDLNLSLNVGVDGSLE 1519 Query: 1487 VQVIANADLYEPXXXXXXXXXXXXXXXXXXXXXXXXXSAVQXXXXXXXXXXXXXXXXXXX 1546 V+V+ NADLYEP S ++ Sbjct: 1520 VRVVVNADLYEPATARSIADALRATLAAFAADPDRKVSELRVLPPQELERLLAPPAPRDT 1579 Query: 1547 XXXXXXXXXXXETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPF 1606 ETER L +LEELL+IT ++ ++N+FALGGDS+I+I+WSA+A ALGL Sbjct: 1580 AGAGAVSGGSAETERTLIQLLEELLDITDVEPEDNFFALGGDSVISIQWSARAAALGLAL 1639 Query: 1607 PPAMVFEHMTIAELAAAVDAANG-EPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 P +VFEHMTIAELAAAVDAA + E+ P E PMSASGL DALA L+ASW Sbjct: 1640 TPQLVFEHMTIAELAAAVDAAGPVDAQAESTAAPQPESAPMSASGLDSDALAALTASWQA 1699 Query: 1666 Q 1666 Q Sbjct: 1700 Q 1700 >tr|B1MPF2|B1MPF2_MYCA9 Tax_Id=561007 SubName: Full=Putative peptide synthetase MbtE;[Mycobacterium abscessus] Length = 1675 Score = 1738 bits (4502), Expect = 0.0 Identities = 921/1661 (55%), Positives = 1138/1661 (68%), Gaps = 20/1661 (1%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +AESG+AA+ P + GER L+ GQRRMWF+QT DP D +LNICVA+R+ G +D+ Sbjct: 20 LAESGVAAQAVESAPRVQAGERRGLAPGQRRMWFMQTKDPADTSLNICVAHRMRGALDQT 79 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RL AV V+ RH +LRT YGVD+ GEPYQ+F ++ EV W DLT L +RQ+ +L Sbjct: 80 RLRDAVAAVIRRHDVLRTVYGVDSAGEPYQLFVEEFEVPWTAVDLTDLTGDAQDRQVRAL 139 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EFGRPFDL + PLR+T++R A++ V+LLVVHHICWDD+SWEVFF ELS Y+ P Sbjct: 140 ADSEFGRPFDLAADRPLRVTLLRLGAEDFVVLLVVHHICWDDNSWEVFFAELSEYYHGRP 199 Query: 200 INDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPL 259 + A QF+ V ++ S AD+ YW L G + R A+R P+ Sbjct: 200 VQGEAPQFMVVSA--DTEPSSDADLTYWRRALTPLPDPLELPGAASTYSSRAARRLAVPM 257 Query: 260 PAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYF 319 PA +R+E+FAR+ SA+PFMVLLAA+GVLV RYTG+ DF+ ++PV ER A A+GYF Sbjct: 258 PAETAARIEEFAREHSATPFMVLLAAFGVLVHRYTGSRDFVTAIPVAERKSNAEKAIGYF 317 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLV 378 GNTLLLR D+F S V VRE CL F HQ+VGID VVRE NP R +G DGMD LV Sbjct: 318 GNTLLLRTVVNPDDSFASHVAAVREVCLDAFGHQNVGIDEVVREVNPSRSIGHDGMDELV 377 Query: 379 RLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVL 437 RLGF+MRK A G L+GV V QL L AV+A LPLSL IA + VEFEYQ L L Sbjct: 378 RLGFSMRKDASGYRLEGVDVTQLDLAAVSAQLPLSLAIATESSGTIVEFEYQTDVLPQWL 437 Query: 438 VDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXX 497 V Q+LVHY +L+ L+ PE L+ L++ A E ++L QSHG L A T+V Sbjct: 438 VGQLLVHYQRLLADGLSRPEETLARLELFDAEEHSALLDQSHGVLTRPSAATLVDLLDAA 497 Query: 498 XXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAM 557 VSD+ ELTY L +R+NR ARW + QG G ED+I L+M+ S+EFIVAM Sbjct: 498 ARATPEALAV--VSDDVELTYELLQQRSNRFARWLVAQGAGTEDVIALQMSTSVEFIVAM 555 Query: 558 LAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDR 617 L VLK+GAAY+PIDPA P+ERI+YLI DA+P+ V+ E VAE AA D P++D+DR Sbjct: 556 LGVLKSGAAYMPIDPALPEERIEYLIADAKPRIVMRPQEFRVAEAAATGLGDAPITDADR 615 Query: 618 LRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFD 677 LRPL P +LAYVIYTSGSTGRPKGVAV+H AIAEHV F AEW+MTA+DR LQ +SVSFD Sbjct: 616 LRPLLPDNLAYVIYTSGSTGRPKGVAVAHAAIAEHVVSFTAEWSMTADDRMLQSTSVSFD 675 Query: 678 ASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQ 737 ASLADI L LGAQL++PKP+ F DI YVADL+ RRGVTV + Sbjct: 676 ASLADILCPLSLGAQLVIPKPNPFSDIGYVADLVRRRGVTVLHMVPSLLGSVLLLPEARE 735 Query: 738 WRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIG 797 R LRHVPVGGEALPGEVAD+FA FDAELRNHYGPTEAVVCST+M V G G +VPIG Sbjct: 736 LRGLRHVPVGGEALPGEVADKFATMFDAELRNHYGPTEAVVCSTYMSVRGPQGNSIVPIG 795 Query: 798 VPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLY 857 PN+NVYAYVLD+ L VP V+GELYLGG+QLARGY RP LTA+RF+ADPF G RLY Sbjct: 796 RPNQNVYAYVLDQALKLVPAGVVGELYLGGAQLARGYRARPVLTAERFVADPFGSGGRLY 855 Query: 858 RTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLV-VAEETEAG 916 RTGDLVRRN GELEFVGRADEQVK+RG+RIELGE+E+VI P V HC+ V ++ + G Sbjct: 856 RTGDLVRRNARGELEFVGRADEQVKVRGYRIELGEIEAVIGADPRVGHCVATVVDDPQVG 915 Query: 917 PMLAAYLVPAAA--QVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAP 974 +LAAY+VPA ++DL+E+RA A+P YMVP AFAVIPEIP+T SGKLD+RALP P Sbjct: 916 SLLAAYVVPAGGTREIDLDELRARAQEALPAYMVPTAFAVIPEIPLTTSGKLDKRALPTP 975 Query: 975 TPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFG 1034 + R +R P T TER +C+I++ LFG++RVG +DSFF LGGHSLLAARLVAQIRA+FG Sbjct: 976 DALTERAFRLPVTPTERRMCAIYSHLFGKERVGLDDSFFELGGHSLLAARLVAQIRAQFG 1035 Query: 1035 VDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNL---AADDMPLDPKRARPGFVKSAR 1091 +DLTVR +FD PTPAGLA +LV FR +FE++LD L +D+M P+ RP V + R Sbjct: 1036 IDLTVRAVFDRPTPAGLAEQLVTYFREEFEIELDELDLDESDEMEAAPQDGRPDLVAAER 1095 Query: 1092 PQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTN 1151 P+RLPLS SQL+ WF+ ++EG + NM LALRF+GP RHEALRTN Sbjct: 1096 PERLPLSSSQLSMWFECQMEGVTDIGNMWLALRFDGPLQTPALIAALNDVVARHEALRTN 1155 Query: 1152 FDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPD 1211 HEG PYQIVHPSR + + + + D +LR H+F E+ L++ ++ L Sbjct: 1156 IAIHEGAPYQIVHPSRELAVPILRSSPEGLSDTLAELRHHIFGLETESLIRPAIIELSAQ 1215 Query: 1212 THVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-- 1269 HVL L+VHHIV DHAS ++ DDLI AYRARL+ APQWD P+Q+ADY +WQR+ F Sbjct: 1216 EHVLALVVHHIVVDHASFTVIVDDLIAAYRARLEGQAPQWDPQPVQYADYVLWQRDAFAP 1275 Query: 1270 ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAER 1329 +S +GQ E+++WR LAG+P EI+VA DRARP++LGKRGEV +F + RR ALT++AE+ Sbjct: 1276 DSEFGQAEVNFWRQQLAGVPTEIAVAHDRARPQILGKRGEVAKFVMEPERRQALTRMAEQ 1335 Query: 1330 NGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGD 1389 G TEFM+YQAALAVVLH+LGGGTDI +GSPVAARV P A+LVGLFAN+V LR DLSGD Sbjct: 1336 RGVTEFMVYQAALAVVLHRLGGGTDIVIGSPVAARVHPHVAKLVGLFANMVALRNDLSGD 1395 Query: 1390 PTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPR 1449 P+LRS+L SRD L+A AHQELPIE+LVEA+NP R+LS NPLFQ M+NFRG DW R Sbjct: 1396 PSLRSVLERSRDATLNAHAHQELPIEKLVEAVNPVRSLSWNPLFQTMVNFRGADWGTAAR 1455 Query: 1450 DLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEPXXXXXXXXXXX 1509 D+T GETTVVPLP+ +V+ L L ++VTPSG LDV V+ANADLY+ Sbjct: 1456 DVTVSGETTVVPLPMEVDVSYLDLNFALNVTPSGGLDVSVVANADLYDHETTRMIAQALD 1515 Query: 1510 XXXXXXXXXXXXXXSAVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXETERRLTAMLEE 1569 S + ET+ L ++LEE Sbjct: 1516 TAFDAFVNNQESRVSEIVLLPADAMAQLMAPPAAAVEPVTTPSVEGSEETKLVLISILEE 1575 Query: 1570 LLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAELAAAVDAANG 1629 LLEI+ +D ++N+FALGGDS+I+I+WS +A GL P MVFE TIA+LA AVDAA+ Sbjct: 1576 LLEISDVDPEDNFFALGGDSVISIQWSTRAAERGLAMTPQMVFECATIAQLAGAVDAAD- 1634 Query: 1630 EPVVEAD----PPPAQEYTPMSASGLAPDALAKLSASWLQQ 1666 V E D PP Q PMSASGL+ DALA+L+ASW Q Sbjct: 1635 RVVTEGDSHLVTPPVQS-APMSASGLSADALAELTASWQAQ 1674 >tr|D0L265|D0L265_GORB4 Tax_Id=526226 SubName: Full=Amino acid adenylation domain protein;[Gordonia bronchialis] Length = 1693 Score = 1395 bits (3610), Expect = 0.0 Identities = 799/1684 (47%), Positives = 1032/1684 (61%), Gaps = 57/1684 (3%) Query: 28 EQSSDQPGIC--PGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAV 85 + SS +P + PG LSD QRRMWF+Q +DP D TLN+CVAYRL+G +D RLH A Sbjct: 23 KSSSPEPVVANEPGTPSPLSDAQRRMWFVQNLDPTDTTLNVCVAYRLSGPLDAARLHQAC 82 Query: 86 NDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFG 145 DVVARH ILR+TYGVD GEP+QV + VE+ W+++DL LP E Q A EF Sbjct: 83 ADVVARHEILRSTYGVDENGEPFQVSAAAVELPWQQDDLRELPVDRRESQAHEWARREFA 142 Query: 146 RPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAA 205 RPFDLT ++P+R++++R +E +L+LVVHH+ WDD+SW VFF E++AAY + P Sbjct: 143 RPFDLTADIPIRVSLLRIADEEHILVLVVHHVGWDDESWPVFFTEVNAAYRGEQVPVPPV 202 Query: 206 QFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXX----GVSGANPCRRAQRRVRPLPA 261 Q++ L N A A++ +W L G + + A R+V P Sbjct: 203 QYVDA-ALGNRPADD-AELDFWRGELSPPPGRVEFGRTQPGTARSRDAGCASRQVSP--- 257 Query: 262 GLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGN 321 L ++ AR + +PF VLL A+ ++ Y+GA+DFLVSVPV R A +GYFGN Sbjct: 258 ALTEQIVGLARAHATTPFTVLLTAFEAAIQFYSGATDFLVSVPVVNRGANAEKLIGYFGN 317 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGR-DGMDLLVRL 380 +LLR F + ++ VR+ A FAHQ+VG+DRVVRE +P R G D + LV++ Sbjct: 318 AVLLRAQPEPTSDFAALLDRVRDASSAAFAHQNVGLDRVVREVSPPRSGGGDALTQLVQV 377 Query: 381 GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD-VSVEFEYQQQ-LSSVLV 438 F+ R +AGG LDGV V +L + A L L I D + VE YQ L+ LV Sbjct: 378 SFSSRSAAGGFDLDGVDVAELPWHSAVAPEDLGLLIVGDGSGGLRVEATYQTAALTPELV 437 Query: 439 DQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXX 498 +Q L HYL+L+ A+ +P PL +DILG ER + A SHG V+ PATTMV Sbjct: 438 EQFLDHYLRLLTAAVGDPSTPLRDIDILGEAERARLSAASHGRQVDTPATTMVALVESQA 497 Query: 499 XXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAML 558 +SD LT+++L RANRLA W IGQG G EDI+ LRM S+EFIVA L Sbjct: 498 ASTPTNDAV--ISDTDHLTFADLDTRANRLAHWMIGQGIGTEDIVALRMTTSVEFIVASL 555 Query: 559 AVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSD---S 615 AVLKAGAAYLP+DPAYP +RIDYL DARP + + D A S P +D + Sbjct: 556 AVLKAGAAYLPMDPAYPADRIDYLRADARPALEL---DFDGYGHAVTSASAYPATDPVDA 612 Query: 616 DRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 DR+RPLRP + AYVIYTSGSTG+PKGV V H+AIAEH+ GF EW +T +DR LQ +SVS Sbjct: 613 DRVRPLRPANTAYVIYTSGSTGQPKGVPVPHNAIAEHLLGFNDEWALTTDDRVLQSTSVS 672 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FDASL DI+VTL GA ++VPK +A+ DI YVADL+SR+GVTV Sbjct: 673 FDASLLDIYVTLTAGACVVVPKANAYRDIPYVADLVSRQGVTVLHMVPSMLATFLMLPEA 732 Query: 736 XQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVP 795 W LRHVPVGGEAL GE+ADRFA FDA LRNHYGPTEAVV STHM V G GA VVP Sbjct: 733 ADWSTLRHVPVGGEALVGEIADRFATQFDAHLRNHYGPTEAVVSSTHMEVEGPQGAGVVP 792 Query: 796 IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMR 855 IG+PN+NV Y+LD+ L VPD V GE+YLGG+QLARGYL R LTAQRF+ADPF PG R Sbjct: 793 IGIPNQNVDLYILDDALRLVPDGVAGEIYLGGNQLARGYLHRAGLTAQRFVADPFRPGAR 852 Query: 856 LYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLV-VAEETE 914 LYRTGDLVRR GE++F+GRADEQVK+RGFRIELGEVE+ IT H V H +V V ++ Sbjct: 853 LYRTGDLVRRKPSGEIDFLGRADEQVKVRGFRIELGEVETTITEHDDVAHAVVIVVDDPV 912 Query: 915 AGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPA 973 AGP LAAYLV + D+E IR++ A +P +MVP F VI E+P+T GKLD+RALPA Sbjct: 913 AGPALAAYLVAGPDSSPDVEAIRSYVAGRLPAHMVPATFTVIEEVPLTAHGKLDKRALPA 972 Query: 974 PTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEF 1033 P +A YREP T+ E+ + ++ LF R +VGA+DSFF LGGHSLLAARL+ +RAEF Sbjct: 973 PEAVAAPEYREPTTSAEKRVAALLGSLFQRDQVGADDSFFTLGGHSLLAARLITMVRAEF 1032 Query: 1034 GVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAAD-DMPLD---------PKRAR 1083 GV+L +R FD+PT LAA + E F ++F + LD D ++ +D A Sbjct: 1033 GVELDMRVPFDSPTVTALAAAIGEAFFDEFGISLDEFDGDPELDVDTGAYGAATADADAA 1092 Query: 1084 P--GFVKS--ARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 P G V + R + +PLS+SQ A W Q R+EGA + N+ LR EGP Sbjct: 1093 PAVGMVPTPQTRSEYIPLSYSQRAYWMQRRMEGAVDGENVTYPLRLEGPIDREALIAAVN 1152 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAID--QDEFDDVSTQLRRHVFTPES 1197 RHE+LRT F EH PYQ++HP++ +++ V +D ++ D +VF + Sbjct: 1153 DVVARHESLRTTFPEHNATPYQLIHPAQPIEVPVVELDGSEERLDRELDADAGYVFDLAA 1212 Query: 1198 GPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQ 1257 LL+ LLVL VL +++HHI++D +S EI DLI AYRAR++ AP+W LPI Sbjct: 1213 ETLLRVRLLVLHEQDCVLSVLLHHIIADRSSCEIFAADLITAYRARVRGQAPEWPALPIG 1272 Query: 1258 FADYAVWQRNTFE-------SNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEV 1310 FAD+A+WQR F+ S+ G+ +LDYWR+ALAGLPDEI+VA D RP++LG G Sbjct: 1273 FADFAIWQRAAFDRGPGRELSDVGRRQLDYWREALAGLPDEINVAHDHPRPQILGHNGIS 1332 Query: 1311 VQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATA 1370 VPA AE GATEFML Q+ A VL+ LG G D+A+G+ VA R+ AT Sbjct: 1333 TARRVPAEIWNRAITNAESVGATEFMLCQSVGASVLNALGAGDDLAIGAAVANRLGEATD 1392 Query: 1371 QLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRN 1430 Q++GLFANVVVLR+DLSGDPT R++L R++ LDA+ HQ +P ERLVE LNPPR+L+RN Sbjct: 1393 QVIGLFANVVVLRSDLSGDPTPRTVLERVRNSALDAITHQGVPFERLVETLNPPRSLARN 1452 Query: 1431 PLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVI 1490 PLFQ M++ R P + G TT + +EV+ + +V +G+L ++++ Sbjct: 1453 PLFQVMMHVRHR---ATPEPFSEDGSTTFRDVAKFYEVSFMDFHFDYTVDVNGDLILRIV 1509 Query: 1491 ANADLYEPXXXXXXXXXXXXXXXXXXXXXXXXXSAV----QXXXXXXXXXXXXXXXXXXX 1546 N DLY+ SA+ Sbjct: 1510 VNPDLYDAATGEVFADVTVGVLEAFANRVDAPLSALDVLPDGWDTSRCVVKHASATPDSA 1569 Query: 1547 XXXXXXXXXXXETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPF 1606 ETER L A+LEELL+I ++R++ +FALGGDS+IAI+W+ +A A+GLP Sbjct: 1570 GPELSADTPVTETERTLIALLEELLDIEDVEREDGFFALGGDSVIAIQWAGRAAAVGLPL 1629 Query: 1607 PPAMVFEHMTIAELAAAVDAANG---EPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 P MVFEH T+ ELAAAVD A EP +D E PMS SGL DALA L SW Sbjct: 1630 TPQMVFEHFTMFELAAAVDDAIANPPEPDGTSDETAPAESAPMSVSGLGDDALAALKDSW 1689 Query: 1664 LQQG 1667 +G Sbjct: 1690 AARG 1693 >tr|C1B2F0|C1B2F0_RHOOB Tax_Id=632772 SubName: Full=Non-ribosomal peptide synthetase;[Rhodococcus opacus] Length = 2218 Score = 1202 bits (3111), Expect = 0.0 Identities = 687/1491 (46%), Positives = 882/1491 (59%), Gaps = 63/1491 (4%) Query: 38 PGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRT 97 P R+ LS+GQRRMWF+ +DP LNI V L G +D DRL +V V ARH +LRT Sbjct: 78 PRSRFPLSEGQRRMWFVHDLDPTHAALNIGVGVELEGALDTDRLFRSVQTVTARHDLLRT 137 Query: 98 TYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLR 157 TY D +G P+QV ++ W D++ L + QI LAA+EF RPFDLT + PLR Sbjct: 138 TYHTDADGTPFQVVAERGTPAWTVHDVSGLAVGERDEQIGRLAAEEFARPFDLTTDPPLR 197 Query: 158 ITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND------LPINDPAAQFLSVE 211 TVIRT + VLLLV HHI WDDDSW +FF +L AY L I D AQ+L VE Sbjct: 198 TTVIRTAPNRHVLLLVAHHIAWDDDSWGLFFADLGEAYESTAPVDALRIRDDTAQYLDVE 257 Query: 212 VLQ--NSAAPSVADVGYWAETLRXXXXXXXXXGVSG---ANPCRRAQRRVRPLPAGLFSR 266 VL +++ DV YW G G A P A R +P + R Sbjct: 258 VLDRPDTSDADREDVAYWRSVYAQPPEALELPGEHGRPSAVPAVSAALGGR-VPDEVAER 316 Query: 267 VEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLR 326 V A K A+PFMVLLAA+ +V RYTG++D L + PV R AA ALGYFGNT++LR Sbjct: 317 VRALAHKTGATPFMVLLAAFVAVVHRYTGSADLLTATPVVNRPAAAGRALGYFGNTVVLR 376 Query: 327 ITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK 386 + +F S V R+ + F HQ G+DRVVRE NP R G G+D L RLGF +R Sbjct: 377 NRVDPRGSFRSLVEHTRDVAVGAFTHQGAGLDRVVREVNPGRGG--GLDALPRLGFGVRS 434 Query: 387 SAG-GLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVH 444 G G G+ + L A +PL + D D +++E EYQ + L L Q+L H Sbjct: 435 GIGTGFRPPGITCARTDLHGAVAQVPLGVMAEFD-DGITLELEYQTEVLDENLAAQLLRH 493 Query: 445 YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXX 504 ++Q + A EP+RP+ +D+LGA +R V S G PA T Sbjct: 494 FVQFLSAASEEPDRPIDVIDLLGA-DRARVSDWSRG--ARAPAATRTLPDLVQARIAETP 550 Query: 505 XXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAG 564 V D+ ++Y+EL RANRLA W I Q GPED++ L S+E +VA LAV++ G Sbjct: 551 DAVALVLDDLRISYAELGARANRLAHWLIAQSIGPEDLVALPFGRSVEMVVAALAVVQTG 610 Query: 565 AAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPG 624 AAYLPIDP YP +RI+YL+TDARP + + +LD AE AA D P +D+DR+RPLR Sbjct: 611 AAYLPIDPTYPADRIEYLLTDARPTSTLD--DLDAAEAAAQDFPATPPTDADRVRPLRTA 668 Query: 625 HLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIF 684 +LAYVIYTSGSTG PKGVA+SH AI EH + E+ ++D LQ +S SFD S+ +IF Sbjct: 669 NLAYVIYTSGSTGLPKGVAISHAAIVEHFEWMEREYVAYSDDALLQVASTSFDVSVGEIF 728 Query: 685 VTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHV 744 TLF GA+L++PKPD DI Y+ L+ VT +W LR V Sbjct: 729 GTLFGGARLVIPKPDGLTDIPYLTTLLRTEHVTAMHFVPSLLGLFLMLPGAEEWTSLRRV 788 Query: 745 PVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVY 804 P+GGEALPGE+AD+F FDA L N YGPTE + +T V G+ G R VPIG P N Sbjct: 789 PIGGEALPGELADKFTATFDAMLHNFYGPTETTLAATRFKVEGAQGTRTVPIGTPKANTE 848 Query: 805 AYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVR 864 YVLD L VP V+GE+Y+GGSQLARGYLGRP LTA+RF+ADP P RLYRTGDL R Sbjct: 849 VYVLDPVLGLVPPGVVGEVYIGGSQLARGYLGRPALTAERFVADPHTPCGRLYRTGDLAR 908 Query: 865 RNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE-AGPMLAAYL 923 N G+LEFVGRAD+QVKIRG+RIELGEVE+ +T HPAV +V+A E+E AG LAAY+ Sbjct: 909 WNSDGDLEFVGRADDQVKIRGYRIELGEVEAAVTAHPAVAAAVVIAHESEAAGKSLAAYV 968 Query: 924 VPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRY 982 V A+ +D ++RA A A+PE+MVP V+ EIP+T +GKLDR ALPAP P A Sbjct: 969 VAASPDALDTADVRARVADALPEHMVPATVTVVREIPITANGKLDRGALPAPEPQAPAPS 1028 Query: 983 REPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTI 1042 REP T TE +C+IFA GR RVG ++SFF LGGHSLLA RLV+++RAEFG D+++R Sbjct: 1029 REPSTPTEARLCAIFADALGRDRVGVDESFFDLGGHSLLATRLVSRLRAEFGADVSIRDA 1088 Query: 1043 FDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQL 1102 F+ PT AGLAA +D AA P RPG ++ RP R+PLS++QL Sbjct: 1089 FEVPTVAGLAAL----------VDARGEAAGASP------RPGLRRAERPPRIPLSYAQL 1132 Query: 1103 AAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQI 1162 WF YR+EG +++P A R +GP RHE LRT + +HEG PYQ+ Sbjct: 1133 RLWFLYRLEGPNPTYDIPFAARIDGPLDAGALAEAIGDVVARHEILRTTYPDHEGKPYQL 1192 Query: 1163 VHPSRTVQLAVRAIDQDEFDDVSTQL-------RRHVFTPESGPLLQANLLVLGPDTHVL 1215 VH + V +D D ++L H F ES ++A +L L P HV+ Sbjct: 1193 VHDPSPID--VPLVDLGAHGDRESRLAAELAEAAAHSFVLESELPIRARILRLAPGEHVV 1250 Query: 1216 LLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQR-----NTFE 1270 L++HHI D S I+F DL VAY ARL AP W LP+Q+ADYA+WQR +T Sbjct: 1251 SLVIHHIAGDEWSAPILFGDLAVAYAARLGGTAPAWPELPLQYADYALWQREMLDDDTST 1310 Query: 1271 SNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERN 1330 G ++ YWR LA LP++ +V DR RP + RG+ V F+VP A LT+LA Sbjct: 1311 DTVGGRQIAYWRSVLADLPEDTTVLRDRPRPPIASSRGDTVTFAVPDRVHAGLTELARTC 1370 Query: 1331 GATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDP 1390 GA+EFM+ Q A+AV+L KLG G DI LG+PVA R E ++VG F N +VLR DLSG+P Sbjct: 1371 GASEFMILQTAVAVLLAKLGAGEDIPLGTPVAGRAEHDLREIVGFFVNTLVLRNDLSGNP 1430 Query: 1391 TLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRD 1450 TLR+ ++ +R+T L A +HQ+LP ERLV+ L P R+LSR+PLFQ +++ R E A Sbjct: 1431 TLRTAVLRARETALGAFSHQDLPFERLVDVLGPDRSLSRHPLFQVLVHLR-ESGAHSEVR 1489 Query: 1451 LTGRGE----TTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 G G TT+VP A L + VT GEL + DLY+ Sbjct: 1490 AVGVGRDVRLTTIVP---ESGTAKFDLTVDFHVT-DGELRGGLNYRTDLYD 1536 Score = 419 bits (1078), Expect = e-114 Identities = 335/1080 (31%), Positives = 491/1080 (45%), Gaps = 66/1080 (6%) Query: 27 AEQSSDQPGICPGER---YRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHT 83 A +S +PG+ ER LS Q R+WFL ++ + T +I A R+ G +D L Sbjct: 1107 AAGASPRPGLRRAERPPRIPLSYAQLRLWFLYRLEGPNPTYDIPFAARIDGPLDAGALAE 1166 Query: 84 AVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADE 143 A+ DVVARH ILRTTY D EG+PYQ+ D + DL E ++ + A+ Sbjct: 1167 AIGDVVARHEILRTTYP-DHEGKPYQLVHDPSPIDVPLVDLGA--HGDRESRLAAELAEA 1223 Query: 144 FGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN------- 196 F L +ELP+R ++R E V+ LV+HHI D+ S + FG+L+ AY Sbjct: 1224 AAHSFVLESELPIRARILRLAPGEHVVSLVIHHIAGDEWSAPILFGDLAVAYAARLGGTA 1283 Query: 197 ----DLPINDPAAQFLSVEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPC 249 +LP+ E+L + + + YW L P Sbjct: 1284 PAWPELPLQYADYALWQREMLDDDTSTDTVGGRQIAYWRSVLADLPEDTTVLRDRPRPPI 1343 Query: 250 R--RAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTE 307 R +P + + + + AR C AS FM+L A VL+ + D + PV Sbjct: 1344 ASSRGDTVTFAVPDRVHAGLTELARTCGASEFMILQTAVAVLLAKLGAGEDIPLGTPVAG 1403 Query: 308 RSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANP 366 R+ + G+F NTL+LR T + V RET L F+HQ + +R+V P Sbjct: 1404 RAEHDLREIVGFFVNTLVLRNDLSGNPTLRTAVLRARETALGAFSHQDLPFERLVDVLGP 1463 Query: 367 ER-MGRDGM-DLLVRL---GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPD 421 +R + R + +LV L G + A G+ D VR + + LT+ Sbjct: 1464 DRSLSRHPLFQVLVHLRESGAHSEVRAVGVGRD---VRLTTIVPESGTAKFDLTVDFHVT 1520 Query: 422 DVSVE--FEYQQQLSSVLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQS 478 D + Y+ L + L +L V A+ P+R L +D+ +R+ +L S Sbjct: 1521 DGELRGGLNYRTDLYDRRTVERLATWLGRVLAEFADHPDRHLRDVDVSAPADRERLLGWS 1580 Query: 479 HGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFG 538 G+ + A V D+ +TY LH ++RLA +G G Sbjct: 1581 RGDAPDPAAPASVPELLEPSRAFGPDVIAVECGDDT-VTYPRLHVLSDRLAALLRRRGAG 1639 Query: 539 PEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELD 598 P + L + SI+ +VA++AV+K+GAA+LP+D YP ER+ ++I DA P V+ + Sbjct: 1640 PGTFVALAVPRSIDMVVALVAVMKSGAAFLPLDLRYPAERLAFMIADAAPVCVVTTGAVG 1699 Query: 599 VAERAAADNSDLPLSDSDRLRPL-----------RPGHLAYVIYTSGSTGRPKGVAVSHH 647 L L D + L R AY ++TSGSTGRPKGV +H Sbjct: 1700 GTLPPVPGVDLLVLDDPATIHDLAGVAVETLPFPRGDEAAYFLFTSGSTGRPKGVVGTHR 1759 Query: 648 AIAEHVQGFVAEWTM-------TAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDA 700 A+A + + + A D L S+SF ++ + GA+LI+ Sbjct: 1760 AMANRLAWQPRLFPVHPPADAPDAGDVRLAQGSLSFLDGGLELLAGIAAGARLILADDAE 1819 Query: 701 FGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFA 760 D+ +A L+ R + R R V G P +A Sbjct: 1820 ARDLEALARLLGRHPIGQVTAVASAVSVLVDTAPDVVRRVPRWVCSGEPLTPSLLAALAG 1879 Query: 761 GYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVI 820 D+++ N YG TE + +V G V+ +G P V VLD+ L PVP V+ Sbjct: 1880 TAPDSDIVNAYGTTE----TAGSIVRGLMEPGVLRVGRPVPGVRLLVLDDALKPVPQGVV 1935 Query: 821 GELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLVRRNHCGELEFVGRAD 878 GE+Y+ G+QLARGY RP LTA RF+A P G RLYRTGD N G L F GR D Sbjct: 1936 GEIYVAGAQLARGYWNRPGLTAARFVAHPSPDRAGERLYRTGDRGSWNPDGHLCFAGRTD 1995 Query: 879 EQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEE---- 934 QVK+RG+RIELGEVE+ + + P V + LA Y+VP D +E Sbjct: 1996 HQVKVRGYRIELGEVENALRSAPGVATAAARTYGRDGATSLAGYVVPRDTGPDRDEGQFL 2055 Query: 935 --IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERW 992 +RAH +P YM+P + +P T SGKLDR +LP P + P TATER Sbjct: 2056 AAVRAHLDRTLPGYMLPATVTALETMPTTGSGKLDRLSLPVPQVATAGHFEPPVTATERA 2115 Query: 993 ICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA 1052 + ++F ++ G VG D FF LGG S+++ +L + R+ G+ LT + +F+ T A LA Sbjct: 2116 LAALFEEILGVTEVGRSDGFFTLGGDSIVSIQLAGRARSA-GLVLTPQLVFEYSTLAELA 2174 Score = 98.6 bits (244), Expect = 7e-18 Identities = 51/109 (46%), Positives = 70/109 (64%), Gaps = 2/109 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIA 1618 TER L A+ EE+L +T + R + +F LGGDSI++I+ + +A + GL P +VFE+ T+A Sbjct: 2112 TERALAALFEEILGVTEVGRSDGFFTLGGDSIVSIQLAGRARSAGLVLTPQLVFEYSTLA 2171 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQG 1667 ELA A D A + E +P PA+ PMS SGL PD LA L SW +G Sbjct: 2172 ELAEACDRAAAQ--AEPEPEPAEPSAPMSVSGLDPDQLAALRKSWDARG 2218 Score = 38.5 bits (88), Expect = 8.3 Identities = 31/82 (37%), Positives = 42/82 (51%), Gaps = 3/82 (3%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTI 1617 TE RL A+ + L + DE++F LGG S++A + ++ A G FE T+ Sbjct: 1035 TEARLCAIFADALGRDRVGVDESFFDLGGHSLLATRLVSRLRAEFGADVSIRDAFEVPTV 1094 Query: 1618 AELAAAVDAANGEPVVEADPPP 1639 A LAA VD A GE A P P Sbjct: 1095 AGLAALVD-ARGE-AAGASPRP 1114 >tr|A0R0U5|A0R0U5_MYCS2 Tax_Id=246196 SubName: Full=Linear gramicidin synthetase subunit B; EC=5.1.1.-;[Mycobacterium smegmatis] Length = 1819 Score = 1096 bits (2834), Expect = 0.0 Identities = 640/1502 (42%), Positives = 855/1502 (56%), Gaps = 62/1502 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +AE GLAA +++ + + LSDGQRRMWF+Q DP V LN+ ++YRL G +D + Sbjct: 24 LAERGLAAGRAAAEGSAAAVDPTVLSDGQRRMWFVQGFDPSGVLLNVSLSYRLTGDIDAE 83 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 R+ AV V RH ILRTT+ D GEP DD+ W DL+ E + ++E L Sbjct: 84 RMQAAVEAVARRHPILRTTFHADENGEPRAEVHDDLTPSWTTHDLSEKSERARKLRLEVL 143 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EFG PFDL E PLR+T+IRT E VLLLV HHI WDD SW VFF +L+ AY+ Sbjct: 144 AQREFGTPFDLGTESPLRLTLIRTGPAEHVLLLVAHHIAWDDGSWRVFFTDLTRAYS--- 200 Query: 200 INDPAAQFLSVEVLQNSAAPSVAD--VGYWAETLRXXXXXXXXXGVSGANPCR--RAQRR 255 + L +AAP D + YW E + G G+ R+QR Sbjct: 201 -----GEQLPETPRVGAAAPDTTDEDLAYWREVMANPPEPLELPGPMGSVVPTGFRSQRS 255 Query: 256 VRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA 315 L A +V AR+ A+P+MVLLAA+G L+RRYT DFLV+ PV R Sbjct: 256 TVRLSAETVEKVTVLARETGATPYMVLLAAFGALIRRYTHTDDFLVATPVLNRD--TEDT 313 Query: 316 LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMD 375 +GY GNT+ +R+ RS F V + R+ L FAHQ V +DRVVRE NP+R R G + Sbjct: 314 IGYHGNTVAMRMRPRSDAGFRDLVLQTRDVALGAFAHQRVNLDRVVRELNPDR--RHGAE 371 Query: 376 LLVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ-L 433 + R+ F R+ GG GV + L LPL + + +VE E+ + L Sbjct: 372 RMTRVSFGFREPDGGGFCPAGVRCERAELRGNHTQLPLGFMVEWEATGATVEAEHLTEVL 431 Query: 434 SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKX 493 + L +QML H+ L+D ALA+P+R L LD+ A + + + GE + PA T+ Sbjct: 432 DAALAEQMLRHFTVLLDNALADPDRALWRLDLFTAEDTAWLTRMATGEAFDTPAATLTDL 491 Query: 494 XXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEF 553 V + TY E++ ANRLA W IGQG G ED + + + S E Sbjct: 492 VTQQAERTPDATAV--VYEGRHFTYREINESANRLAHWLIGQGIGTEDRVAVLLEKSPEL 549 Query: 554 IVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLS 613 ++ L ++KAGA YLP+DP YP++R++Y+++D+ P+ V+ + ++ D +D Sbjct: 550 VITALGIVKAGAVYLPVDPTYPEDRLNYILSDSDPKIVLREFVTGLDDQPTTDPTD---- 605 Query: 614 DSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSS 673 ++R+RPLRP + AY+IYTSGSTG PKGV V H IAE+ F E+ +T EDR LQ +S Sbjct: 606 -AERVRPLRPDNTAYLIYTSGSTGLPKGVPVPHRPIAEYFVWFGGEYDVTNEDRLLQVAS 664 Query: 674 VSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXX 733 SFD S+ +IF L GA+L++PKP DI Y+ DL+ G+T Sbjct: 665 QSFDVSIGEIFGMLAAGARLVIPKPGGLTDIGYLTDLLRNEGITSMHFVPSLLGLFLSLP 724 Query: 734 XXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARV 793 +WR L+ VP+GGEALPGE+AD+F FD+ L N YGPTE V+ T V G GAR Sbjct: 725 GVNEWRTLQRVPIGGEALPGEIADKFHATFDSLLHNFYGPTETVLNCTRYKVEGKQGART 784 Query: 794 VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPG 853 VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY RP +TA+RF+ADPFNPG Sbjct: 785 VPIGKPKINTTIHLLDDALQPVPVGVIGEIYIGGTHVAHGYHRRPGMTAERFVADPFNPG 844 Query: 854 MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEET 913 R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELGEV + I+ P+V +VV + Sbjct: 845 GRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGEVSAAISVDPSVGQAVVVVSDL 904 Query: 914 EA-GPMLAAYLVPAAA--QVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRA 970 + G L AY+ PAA VD+E IRA AA+PEYMVP A+ + EIP+T GK+DRRA Sbjct: 905 PSLGKSLVAYITPAAGADHVDIERIRARVTAALPEYMVPAAYVELDEIPITTHGKIDRRA 964 Query: 971 LPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIR 1030 LP P +T R+REP T TER + +FA+L R VGA+DSFF LGGHSLLA +LVA +R Sbjct: 965 LPEPEITSTTRFREPSTDTERTVAGLFAELLERDEVGADDSFFDLGGHSLLATKLVAAVR 1024 Query: 1031 AEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSA 1090 A VD+ V+ +F+ T +GLAA +++L A RP V Sbjct: 1025 ARCAVDVGVQDVFEHATVSGLAAH------------IEDLVAS----GASSGRPAIVAVP 1068 Query: 1091 RPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRT 1150 L +S +QL WFQ+RI+G N+P A R GP RHE LRT Sbjct: 1069 HDGPLQMSAAQLRQWFQFRIDGPNPVNNVPFAARLSGPCDVDALIAAVGDVVARHEILRT 1128 Query: 1151 NFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESGPLLQANLLV 1207 + E +G PYQI+HP V VR D D V QL RR+ F E+ ++A +L Sbjct: 1129 TYREIDGAPYQIIHPPAPV--PVRQARGDGEDWVQAQLDAERRYCFDLETDWPIRAAVLT 1186 Query: 1208 LGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRN 1267 + HVL L+VHHI +DH S ++F DL+ AY AR +A + LP+Q+AD+A WQ Sbjct: 1187 TA-EHHVLSLVVHHIAADHWSGTVLFTDLLTAYHARHAGSAVELPPLPVQYADFAAWQAE 1245 Query: 1268 TF--ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQ 1325 + + YW LAGLP+E + D RP V G + FS+ A RA L Sbjct: 1246 LLAGTDDTIDEQRRYWTTQLAGLPEENGLYPDFPRPPVPTGDGAALDFSIDADTRARLIA 1305 Query: 1326 LAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTD 1385 L G TEFML QAA+A+ LHK G GTDI LG+PVA R P L+G F N+VVLR D Sbjct: 1306 LTRELGVTEFMLLQAAVAIALHKSGQGTDIPLGTPVAGRTAPELDALIGFFINIVVLRND 1365 Query: 1386 LSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWA 1445 LSG+P+LR +L SR+ L A HQ+LP +R+V+A++P R+LSRNPLF +++ R + A Sbjct: 1366 LSGNPSLREVLRRSREMALAAYQHQDLPFDRVVDAVSPVRSLSRNPLFGVVVHVRDDLPA 1425 Query: 1446 LVPRDLTGRGETTVVPLPVNFEVALLFLAI---------GMSVTPSGELDVQVIANADLY 1496 D G GET L F+VA L++ G + P+G VI +LY Sbjct: 1426 DQVIDDGGNGETRFTALEPTFDVAHADLSLNFFAQNGNGGRAGEPAGYKGT-VIYRTELY 1484 Query: 1497 EP 1498 EP Sbjct: 1485 EP 1486 Score = 115 bits (287), Expect = 7e-23 Identities = 92/303 (30%), Positives = 137/303 (45%), Gaps = 26/303 (8%) Query: 755 VADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRN--VYAYVLDEQL 812 + D FA D LR+ + ++ R VP +P YVLDE L Sbjct: 1499 IIDAFATDADTTLRD----IAVIDADERTLLIEDWSRRAVPPALPQTEGATNVYVLDEWL 1554 Query: 813 HPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELE 872 PV VIG++Y G + + AQRF+ +PF G RLYRTGD R G LE Sbjct: 1555 EPVAIGVIGDVYYAGGAVDASAEAANGVAAQRFVPNPFGAG-RLYRTGDRARWTPDGRLE 1613 Query: 873 FVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQVDL 932 V + +++ L V+ V A R+ E + P+LAAY+V AA Sbjct: 1614 PVTAGEPRLQAA-----LEAVDGVAAA--ATRYW-----ENRSAPLLAAYVVADAAHAAD 1661 Query: 933 EEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERW 992 + A+P+ A V+ ++ + P + A+ + P T TER Sbjct: 1662 PQFAEQVRTALPDEFAGAAITVVDDLTPAALTR------PRVSATASGPFEAPATPTERA 1715 Query: 993 ICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA 1052 + ++ +L G +VG D FF LGG S+LA +L A+ R + GV +T R +F+ P + LA Sbjct: 1716 VAAMLVELLGVTQVGRHDDFFTLGGDSILAVQLAARAR-DAGVAMTARMVFEHPVLSELA 1774 Query: 1053 ARL 1055 A + Sbjct: 1775 AAI 1777 Score = 90.1 bits (222), Expect = 2e-15 Identities = 49/107 (45%), Positives = 68/107 (63%), Gaps = 5/107 (4%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIA 1618 TER + AML ELL +T + R +++F LGGDSI+A++ +A+A G+ MVFEH ++ Sbjct: 1712 TERAVAAMLVELLGVTQVGRHDDFFTLGGDSILAVQLAARARDAGVAMTARMVFEHPVLS 1771 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAA+DAA E + PM ASGL+ D LA L+A+W Q Sbjct: 1772 ELAAAIDAAG-----EGSAAQDVHHAPMEASGLSSDELAALTAAWGQ 1813 Score = 47.8 bits (112), Expect = 0.014 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMT 1616 +TER + + ELLE + D+++F LGG S++A K A A + VFEH T Sbjct: 982 DTERTVAGLFAELLERDEVGADDSFFDLGGHSLLATKLVAAVRARCAVDVGVQDVFEHAT 1041 Query: 1617 IAELAAAVD------AANGEPVVEADP 1637 ++ LAA ++ A++G P + A P Sbjct: 1042 VSGLAAHIEDLVASGASSGRPAIVAVP 1068 >tr|A0QE94|A0QE94_MYCA1 Tax_Id=243243 SubName: Full=Linear gramicidin synthetase subunit D; EC=1.-.-.-; EC=5.1.1.-;[Mycobacterium avium] Length = 2190 Score = 1076 bits (2782), Expect = 0.0 Identities = 632/1512 (41%), Positives = 861/1512 (56%), Gaps = 74/1512 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +AE GL S G + R+S GQ RMWF+Q++DPD LNICV+YRL G VD Sbjct: 23 LAERGL-----SRSAGTARHDEPRMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTG 77 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RLH AV+ V ARH +L TTY EG+P V D+ W DL+ L E +++ L Sbjct: 78 RLHRAVDAVAARHPVLHTTYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVL 137 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A +F RPFDL+ + PLR+T R DEL+LL+ HHI WDD SW FF +L+ AY Sbjct: 138 AQRDFRRPFDLSKDSPLRVTAARLADDELMLLITAHHIAWDDGSWAPFFADLTRAYT--- 194 Query: 200 INDPAAQFLSVEVLQNSAAPSVA----DVGYWAETLRXXXXXXXXXGVSGA--NPCRRAQ 253 F + V+ + +A A D+ YW + G +G+ RAQ Sbjct: 195 ---APGDFDATPVVPDLSADPTAIRREDLDYWRPLMADLPEPLELPGPNGSVVPSTWRAQ 251 Query: 254 RRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA 313 R LPA + R AR+ A+P+MVL+AA+ LV RYTG++DFLV+ PV R A Sbjct: 252 RAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAATE 311 Query: 314 GALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 +GY+GNT+++R+ +S +F + + R+ + FAH +D +VRE+NP+R R G Sbjct: 312 NVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR--RHG 369 Query: 374 MDLLVRLGFNMRKSAG-GLALDGVVVRQLGLGAVAAHLPLSLTIALD--PDDVS---VEF 427 D + R+ F R+ G G GV + L LPLSL + L+ PD VE Sbjct: 370 ADRMTRVSFGQREPDGAGFCPPGVRCERGDLRGHFNQLPLSLMVELNRTPDGSGGGLVEA 429 Query: 428 EYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMP 486 EY + L LV+QML HY L+D L++P+ LS+ ++ + + + A S GE P Sbjct: 430 EYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRAVSTGEQFITP 489 Query: 487 ATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLR 546 A T+ + V + TY ++ +NR+A W I +G G ED + + Sbjct: 490 AATLSELVSRRAARTPDAVAV--VYEGRTYTYRDIEEESNRVAHWLIERGVGTEDRVAVL 547 Query: 547 MANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAAD 606 + S E ++ L VLKAG YLP+DP YP +R+++++ DA + V+ P D+A+ A Sbjct: 548 LDKSPELVITALGVLKAGGVYLPVDPTYPQDRLNFILGDADAKLVLREPVTDLADYPATA 607 Query: 607 NSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAED 666 ++L LRPL P + AY+IYTSGSTG PKGV V H IAE+ F E+ + D Sbjct: 608 PTEL-------LRPLTPQNTAYLIYTSGSTGLPKGVPVPHAPIAEYFVWFGDEYRIDETD 660 Query: 667 RWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXX 726 R LQ +S SFD S+ +IF TL +GA+L++P+PD DI Y+ +L++R G+T Sbjct: 661 RLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSMHFVPSLL 720 Query: 727 XXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVT 786 QWR LR VP+GGEALPGE+AD+F FDA L N YGPTE VV T V Sbjct: 721 GLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFYGPTETVVNCTSYPVE 780 Query: 787 GSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFI 846 G+ G RVVPIG P N Y+LD L PVP VIGE+Y+ G+ +A GY RP LTA+RF+ Sbjct: 781 GAQGTRVVPIGRPKINTRVYLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFV 840 Query: 847 ADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHC 906 ADPF+ G R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELGE+ + I+ P+V Sbjct: 841 ADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELGEIAAAISVDPSVGQA 900 Query: 907 LVVAEE-TEAGPMLAAYLVPA----AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMT 961 +V+A + + G L Y+ PA VD+E IRA AAA+P+YM P A+ V+ EIP+T Sbjct: 901 VVLAMDLPQLGKSLVGYVTPAQGAGTETVDVERIRARVAAALPDYMTPAAYVVLDEIPIT 960 Query: 962 VSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLL 1021 K+DR ALP P A YR+P T TE I +F+ L G +RVG +DSFF LGGHSL+ Sbjct: 961 AHQKIDRAALPQPQIGAGTEYRDPTTPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLV 1020 Query: 1022 AARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKR 1081 A +LV IRAE GV++ +R +F+ T LA R +D L++ ++ Sbjct: 1021 ATKLVTAIRAECGVEIGIRDVFELATVGLLAER------------VDQLSSGEL----TG 1064 Query: 1082 ARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXX 1141 RP + +A + LPLS SQL +WF YR++G N+P A R GP Sbjct: 1065 TRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDV 1124 Query: 1142 XXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESG 1198 RHE LRT + E +GVPYQ+V P V++ VR D + + QL RRH F + Sbjct: 1125 VARHEILRTRYVELDGVPYQVVGPP-GVEIPVRREDGPDDPWLQQQLDAERRHCFELDGE 1183 Query: 1199 -PLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQ 1257 P+ A L V HVL L+VHHI SDH S ++F D++ AYRAR AP W L +Q Sbjct: 1184 LPIRVAVLRVANAAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQ 1243 Query: 1258 FADYAVWQRNTFESNWGQ------TELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV 1311 +ADYA WQR GQ + +YW LAGLP++ + D R V GE V Sbjct: 1244 YADYAAWQRTFLGDAGGQESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGESV 1303 Query: 1312 QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQ 1371 F + AA RA L + G TEFML Q A+AVVLHK GGG DI LG+PVA R E Q Sbjct: 1304 DFHIDAATRAKLADVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQ 1363 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 L+G F N++VLR DL G+PTLR +L +R+T L A AHQ+LP +R+V++++P R+LSRNP Sbjct: 1364 LIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNP 1423 Query: 1432 LFQNMLNFRGEDWA---LVPRDLTGRGETTV-VPLPVNFEVALLFLAIGMSVTP-SGEL- 1485 LFQ +++ R A + + G G+ TV L F++A L++ T +G++ Sbjct: 1424 LFQVVVHVRDHLSATRVIETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGAGDIG 1483 Query: 1486 -DVQVIANADLY 1496 + +I DLY Sbjct: 1484 YNCHLIFRTDLY 1495 Score = 427 bits (1097), Expect = e-117 Identities = 355/1106 (32%), Positives = 501/1106 (45%), Gaps = 102/1106 (9%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q R WF MD NI A RL G D D L AV DVVARH ILRT Y V+ Sbjct: 1080 LSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDVVARHEILRTRY-VEL 1138 Query: 104 EGEPYQVFSDD-VEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 +G PYQV VE+ RRED P ++Q+++ E F+L ELP+R+ V+R Sbjct: 1139 DGVPYQVVGPPGVEIPVRREDGPDDPWL--QQQLDA----ERRHCFELDGELPIRVAVLR 1192 Query: 163 T-RADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----DLPINDPA-AQFLSVEVLQN 215 A E VL LVVHHI D S V F ++ AY + P P Q+ Q Sbjct: 1193 VANAAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQR 1252 Query: 216 S---------AAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAG---- 262 + +A + A YW L +G P Q P+P+G Sbjct: 1253 TFLGDAGGQESAVAGAQREYWTRQLAGLPED------TGLRPDFPRQ----PVPSGDGES 1302 Query: 263 --------LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 +++ D R+ + FM+L A V++ + G D + PV R+ A Sbjct: 1303 VDFHIDAATRAKLADVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELD 1362 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRD 372 L G+F N L+LR T + RET LA +AHQ + DRVV +P R + R+ Sbjct: 1363 QLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRN 1422 Query: 373 GM-DLLVRLGFNMRKS-------AGGLALDGVVVRQLGLGAVAAHLPLSL----TIALDP 420 + ++V + ++ + GG D V L AH LS+ T Sbjct: 1423 PLFQVVVHVRDHLSATRVIETAPVGGDGQD-TVCTSLDPVFDMAHADLSVNFFGTDGAGD 1481 Query: 421 DDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEP-ERPLSSLDILGAGERDSVLAQ-S 478 + ++ L + L +L A A+ ++ L + ++ AGE+ +L Q S Sbjct: 1482 IGYNCHLIFRTDLYRRTTIERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWS 1541 Query: 479 HGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFG 538 G + E + Y LHRR++ LA + +G G Sbjct: 1542 RGAQPPRDRPRTIPELLQASRSLGADRIAVRCGAE-HIDYPALHRRSDNLAALLVDRGVG 1600 Query: 539 PEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL- 597 P ++GL SIE +VA++A++KAGA Y P+DP YP R +++ D RP V+ E Sbjct: 1601 PGTLVGLSTRRSIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAV 1660 Query: 598 ---------------DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGV 642 D RA D D+ + RLRP P Y+++TSGSTG+PKG Sbjct: 1661 DTMPGLPGVELLSLDDPQVRALVDRDDVD-PRAGRLRPPHPDDPMYLVFTSGSTGKPKGA 1719 Query: 643 AVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFG 702 +H ++A + + + +D L +S++F ++ L GA +I+ Sbjct: 1720 VGTHRSMAARLDWQLRHYPPRTDDVRLAQASITFLEGGMEMLAGLAAGATMILADDAEHR 1779 Query: 703 DISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGY 762 D + +L+ R V R L + GGE + + R Sbjct: 1780 DPEALGELMHRHSV-AQVTAVPSLVSALLDSRPDAVRSLSRLVCGGEPVSTSLLQRLVSV 1838 Query: 763 FD------AELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVP 816 D EL N+ G TE ++ V G +G P AY+LD+ L PVP Sbjct: 1839 CDEADGGGPELLNNIGSTE----TSGAVSRGPLSPPNPLVGKPVPGAQAYLLDDGLRPVP 1894 Query: 817 DQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLVRRNHCGELEFV 874 V+GELY G QLARGY RP LTA RF+A+PF PG RLYR+GDL R G+LEFV Sbjct: 1895 VGVVGELYYAGDQLARGYWKRPGLTAARFVANPFGAEPGSRLYRSGDLARWTEDGQLEFV 1954 Query: 875 GRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEE 934 GR+D QV++RGFR+EL EVE+ + V E G LA Y+VP D E Sbjct: 1955 GRSDHQVQVRGFRVELAEVEAALAGADGVAAAAARTWEVHGGTSLAGYVVPQRPIADEAE 2014 Query: 935 -------IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPET 987 +RA AA +P YM+P + V+ +P T SGKL+R LP P R T Sbjct: 2015 KAAFAAQVRAEIAATLPGYMMPSSLTVLDALPKTESGKLNRPGLPRPAVSTGGRTEPART 2074 Query: 988 ATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPT 1047 TER + ++FA+L VG D FF LGG S+L+ +L ++ RA G+ ++ R IF+ PT Sbjct: 2075 DTERALANVFAELLSTPEVGRFDDFFALGGDSILSVQLASRARAA-GLPVSPRMIFENPT 2133 Query: 1048 PAGLAARLVERFRNDFELDLDNLAAD 1073 LAA L ND + LD+ AD Sbjct: 2134 VQQLAAALDALGDNDSDGRLDDQPAD 2159 Score = 81.3 bits (199), Expect = 1e-12 Identities = 44/108 (40%), Positives = 66/108 (61%), Gaps = 2/108 (1%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 +TER L + ELL + R +++FALGGDSI++++ +++A A GLP P M+FE+ T+ Sbjct: 2075 DTERALANVFAELLSTPEVGRFDDFFALGGDSILSVQLASRARAAGLPVSPRMIFENPTV 2134 Query: 1618 AELAAAVDAA--NGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 +LAAA+DA N D P + PMS SGL+ LA ++ W Sbjct: 2135 QQLAAALDALGDNDSDGRLDDQPADTRFEPMSTSGLSASDLAAVTQLW 2182 >tr|Q73XY5|Q73XY5_MYCPA Tax_Id=1770 (mbtE)SubName: Full=MbtE;[Mycobacterium paratuberculosis] Length = 1759 Score = 1070 bits (2768), Expect = 0.0 Identities = 631/1513 (41%), Positives = 858/1513 (56%), Gaps = 76/1513 (5%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +AE GL S G + R+S GQ RMWF+Q++DPD LNICV+YRL G VD Sbjct: 23 LAERGL-----SRSTGTARHDEPRMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTG 77 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RLH AV+ V ARH +L TTY EG+P V D+ W DL+ L E +++ L Sbjct: 78 RLHRAVDAVAARHPVLHTTYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVL 137 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A +F RPFDL+ + PLR+T R +EL+LL+ HHI WDD SW FF +L+ AY Sbjct: 138 AQRDFRRPFDLSKDSPLRVTAARLADEELMLLITAHHIAWDDGSWAPFFADLTRAYA--- 194 Query: 200 INDPAAQFLSVEVLQNSAAPSVA----DVGYWAETLRXXXXXXXXXGVSGA--NPCRRAQ 253 F + V+ + +A A D+ YW + G +G+ RAQ Sbjct: 195 ---APGDFDTTPVVPDLSADPTAIRREDLDYWRPLMADLPEPLELPGPNGSVVPSTWRAQ 251 Query: 254 RRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA 313 R LPA + R AR+ A+P+MVL+AA+ LV RYTG++DFLV+ PV R A Sbjct: 252 RAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAATE 311 Query: 314 GALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 +GY+GNT+++R+ +S +F + + R+ + FAH +D +VRE+NP+R R G Sbjct: 312 NVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR--RHG 369 Query: 374 MDLLVRLGFNMRKSAGG-LALDGVVVRQLGLGAVAAHLPLSLTIALD--PDDVS---VEF 427 D + R+ F R+ G GV + L LPLSL I L+ PD VE Sbjct: 370 ADRMTRVSFGQREPDGASFCPPGVRCERGDLRGHFNQLPLSLMIELNRTPDGSGGGLVEA 429 Query: 428 EYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMP 486 EY + L LV+QML HY L+D L++P+ LS+ ++ + + + A S GE P Sbjct: 430 EYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRAVSTGEQFITP 489 Query: 487 ATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLR 546 A T+ + V + TY ++ +NR+A W I +G G ED + + Sbjct: 490 AATLSELVSHRAARTPDAVAV--VYEGHTYTYRDIEEESNRVAHWLIERGVGTEDRVAVL 547 Query: 547 MANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAAD 606 + S E ++ L VLKAG YLP+DP YP +R+++++ DA + V+ P D+A+ A Sbjct: 548 LDKSPELVITALGVLKAGGVYLPVDPTYPQDRLNFILGDADAKLVLREPVTDLADYPATA 607 Query: 607 NSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAED 666 ++L LRPL P + AY+IYTSGSTG PKGV V H IAE+ F E+ + D Sbjct: 608 PTEL-------LRPLTPQNTAYLIYTSGSTGLPKGVPVPHAPIAEYFVWFGDEYRIDETD 660 Query: 667 RWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXX 726 R LQ +S SFD S+ +IF TL +GA+L++P+PD DI Y+ +L++R G+T Sbjct: 661 RLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSMHFVPSLL 720 Query: 727 XXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVT 786 QWR LR VP+GGEALPGE+AD+F FDA L N YGPTE VV T V Sbjct: 721 GLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFYGPTETVVNCTSYPVE 780 Query: 787 GSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFI 846 G+ G RVVPIG P N Y+LD L PVP VIGE+Y+ G+ +A GY RP LTA+RF+ Sbjct: 781 GAQGTRVVPIGRPKINTRVYLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFV 840 Query: 847 ADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHC 906 ADPF+ G R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELGE+ + I+ P+V Sbjct: 841 ADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELGEIAAAISVDPSVGQA 900 Query: 907 LVVAEE-TEAGPMLAAYLVPA----AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMT 961 +V+A + + G L Y+ PA VD+E IRA AAA+P+YM P A+ V+ EIP+T Sbjct: 901 VVLAMDLPQLGKSLVGYVTPAQGAGTETVDVERIRARVAAALPDYMTPAAYVVLDEIPIT 960 Query: 962 VSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLL 1021 K+DR ALP P A YR+P T TE I +F+ L G +RVG +DSFF LGGHSL+ Sbjct: 961 AHQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLV 1020 Query: 1022 AARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKR 1081 A +LV IRAE GV++ +R +F+ T LA R +D L++ ++ Sbjct: 1021 ATKLVTAIRAECGVEIGIRDVFELATVGLLAER------------VDQLSSGEL----TG 1064 Query: 1082 ARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXX 1141 RP + +A + LPLS SQL +WF YR++G N+P A R GP Sbjct: 1065 TRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDV 1124 Query: 1142 XXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESG 1198 RHE LRT + E +GVPYQ+V P V++ VR D + + QL RRH F + Sbjct: 1125 VARHEILRTRYVELDGVPYQVVGPP-GVEIPVRREDGPDDPWLQQQLDAERRHCFELDGE 1183 Query: 1199 -PLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQ 1257 P+ A L V HVL L+VHHI SDH S ++F D++ AYRAR AP W L +Q Sbjct: 1184 LPIRVAVLRVANAAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQ 1243 Query: 1258 FADYAVWQRNTFESNWGQ------TELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV 1311 +ADYA WQR GQ + +YW LAGLP++ + D R V GE V Sbjct: 1244 YADYAAWQRTFLGDAGGQESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGESV 1303 Query: 1312 QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQ 1371 F + AA R L ++ G TEFML Q A+AVVLHK GGG DI LG+PVA R E Q Sbjct: 1304 DFHIDAATRVKLAEVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQ 1363 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 L+G F N++VLR DL G+PTLR +L +R+T L A AHQ+LP +R+V++++P R+LSRNP Sbjct: 1364 LIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNP 1423 Query: 1432 LFQNMLNFRGEDWA---LVPRDLTGRGETTV-VPLPVNFEVALLFLAIGMSVTPSGELDV 1487 LFQ +++ R A + + G G+ TV L F++A L++ T G D+ Sbjct: 1424 LFQVVVHVRDHLSATRVIETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGT-DGASDI 1482 Query: 1488 ----QVIANADLY 1496 +I DLY Sbjct: 1483 GYNCHLIFRTDLY 1495 Score = 182 bits (463), Expect = 3e-43 Identities = 186/631 (29%), Positives = 269/631 (42%), Gaps = 72/631 (11%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q R WF MD NI A RL G D D L AV DVVARH ILRT Y V+ Sbjct: 1080 LSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDVVARHEILRTRY-VEL 1138 Query: 104 EGEPYQVFSDD-VEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 +G PYQV VE+ RRED P ++Q+++ E F+L ELP+R+ V+R Sbjct: 1139 DGVPYQVVGPPGVEIPVRREDGPDDPWL--QQQLDA----ERRHCFELDGELPIRVAVLR 1192 Query: 163 T-RADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----DLPINDPA-AQFLSVEVLQN 215 A E VL LVVHHI D S V F ++ AY + P P Q+ Q Sbjct: 1193 VANAAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQR 1252 Query: 216 S---------AAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSR 266 + +A + A YW L +G P Q P+P+G Sbjct: 1253 TFLGDAGGQESAVAGAQREYWTRQLAGLPED------TGLRPDFPRQ----PVPSGDGES 1302 Query: 267 VE------------DFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 V+ + R+ + FM+L A V++ + G D + PV R+ A Sbjct: 1303 VDFHIDAATRVKLAEVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELD 1362 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRD 372 L G+F N L+LR T + RET LA +AHQ + DRVV +P R + R+ Sbjct: 1363 QLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRN 1422 Query: 373 GM-DLLVRLGFNMRKS-------AGGLALDGVVVRQLGLGAVAAHLPLSL----TIALDP 420 + ++V + ++ + GG D V L AH LS+ T Sbjct: 1423 PLFQVVVHVRDHLSATRVIETAPVGGDGQD-TVCTSLDPVFDMAHADLSVNFFGTDGASD 1481 Query: 421 DDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEP-ERPLSSLDILGAGERDSVLAQ-S 478 + ++ L + L +L A A+ ++ L + ++ AGE+ +L Q S Sbjct: 1482 IGYNCHLIFRTDLYRRTTIERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWS 1541 Query: 479 HGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFG 538 G + E + Y LHRR++ LA + +G G Sbjct: 1542 RGAQPPRDRPRTIPELLQPTRSLGADRIAVRCGAE-HIDYPALHRRSDNLAALLVDRGVG 1600 Query: 539 PEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG----- 593 P ++GL IE +VA++A++KAGA Y P+DP YP R +++ D RP V+ Sbjct: 1601 PGTLVGLSTRRGIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAV 1660 Query: 594 --RPELDVAERAAADNSDL-PLSDSDRLRPL 621 P L E + D+ + L D DR P+ Sbjct: 1661 DTMPALPGVELLSLDDPQVRALVDRDRPTPM 1691 >tr|C6DNA4|C6DNA4_MYCTK Tax_Id=478434 SubName: Full=Peptide synthetase mbtE;[Mycobacterium tuberculosis] Length = 1731 Score = 1068 bits (2763), Expect = 0.0 Identities = 631/1502 (42%), Positives = 845/1502 (56%), Gaps = 68/1502 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +A+ GL SS I P RLSDGQ RMWF+Q DP LNICV+YR+ G +D Sbjct: 23 LADRGL----SSAAQDIGPHTDDRLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLA 78 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RL AVN V RH ILRTTY V +G D+ GW + DLT L + ++E L Sbjct: 79 RLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVL 138 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EF PF+L+ + PLRITV+RT ADE VLLLV HHI WDD SW VFF +L+ AY+ Sbjct: 139 AQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRAD 198 Query: 200 INDPAAQFLSVEVLQNSAA---PSVADVGYWAETLRXXXXXXXXXGVSGA--NPCRRAQR 254 + L E ++A+ + AD+ YW + G +G RA R Sbjct: 199 LGAD----LGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAAR 254 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 LPA +RV A+ +P+MVLLAA+G LV RYT + DFLV+ PV R Sbjct: 255 ATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTED 314 Query: 315 ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 A+GYFGNT+ +R+ +S +F + R+ FAHQ + +DRVVRE NP+R R G Sbjct: 315 AIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR--RHGA 372 Query: 375 DLLVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ- 432 + + R+ F R+ GG G+ + L + LPL + D V VE E+ + Sbjct: 373 ERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEI 432 Query: 433 LSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 L L QML H+ L+D ALA P+ LS L ++ + + S GE + P T+V Sbjct: 433 LEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVD 492 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 V + TY +L+ +NRL W I QG G ED + + + S + Sbjct: 493 LVNEQTTRTPDATAV--VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPD 550 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPL 612 IV L V+K+GA Y+P+DP+YP +R+D+++ D + V+ P ++A SD P Sbjct: 551 LIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELA----GYRSDDP- 605 Query: 613 SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFS 672 +D+DR+RPLRP + AY+IYTSG+TG PKGVAV H +AE+ F E+ + DR LQ + Sbjct: 606 TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVA 665 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 S SFD S+A+IF TL GA++++P+P DI Y+ L+ G+T Sbjct: 666 SPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSL 725 Query: 733 XXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGAR 792 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V G G R Sbjct: 726 PGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTR 785 Query: 793 VVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP 852 +VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY R LTA+RF+ADPFNP Sbjct: 786 IVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP 845 Query: 853 GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEE 912 G R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I P V +VV + Sbjct: 846 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 905 Query: 913 -TEAGPMLAAYLVPAA-------AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSG 964 G L Y+ PAA VDL+ IRA AAA+PEYM+P A+ V+ EIP+T G Sbjct: 906 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 965 Query: 965 KLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAAR 1024 K+DR ALP P + +R P+TATER + +F +L GR RVGA+DSFF LGGHSLLA + Sbjct: 966 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 1025 Query: 1025 LVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 LVA +R FGVD+ VR IF+ T LA +D L +D ARP Sbjct: 1026 LVAAVRNAFGVDVGVREIFEFATVTALAGH------------IDTLDSDS-------ARP 1066 Query: 1085 GFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXR 1144 + + LS SQ+ +WF YR +G N+P A GP R Sbjct: 1067 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1126 Query: 1145 HEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESGPLL 1201 HE LRT + E GVP+QI+ P ++ VR + + +L R +VF E+ + Sbjct: 1127 HEILRTVYREIGGVPHQIIQP--PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPI 1184 Query: 1202 QANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADY 1261 +A LL P+ VL L+VHHI DH S ++F DL+ AYRAR P W LP+Q+ADY Sbjct: 1185 RAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1243 Query: 1262 AVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 +VWQ + G + DYW L GL E + D RP +L G+ V+F + AA Sbjct: 1244 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI 1303 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 R L ++ G TEFML QAA+AVVLHK GGG D+ +G+PVA R E QL+G F N+ Sbjct: 1304 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINI 1363 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 VVLR DL G+PTLR +L +R L A AHQ+LP +++VEA+NP R+LSRNPLF +++ Sbjct: 1364 VVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV 1423 Query: 1440 RGEDWALVPRDL---TG-RGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADL 1495 R + +P+D TG G+TT+ L F+ A L++ E VI +L Sbjct: 1424 REQ----MPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC-GDEYRGHVIYRTEL 1478 Query: 1496 YE 1497 YE Sbjct: 1479 YE 1480 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1626 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1685 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1686 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1729 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1534 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1591 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1592 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1633 Query: 922 YL 923 L Sbjct: 1634 IL 1635 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1611 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1669 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1670 GGIPLTARMVFEHPVLCELAA 1690 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 990 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1049 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1050 TALAGHIDTLDSD 1062 >tr|Q7D791|Q7D791_MYCTU Tax_Id=1773 SubName: Full=Peptide synthetase;[Mycobacterium tuberculosis] Length = 1787 Score = 1068 bits (2763), Expect = 0.0 Identities = 631/1502 (42%), Positives = 845/1502 (56%), Gaps = 68/1502 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +A+ GL SS I P RLSDGQ RMWF+Q DP LNICV+YR+ G +D Sbjct: 79 LADRGL----SSAAQDIGPHTDDRLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLA 134 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RL AVN V RH ILRTTY V +G D+ GW + DLT L + ++E L Sbjct: 135 RLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVL 194 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EF PF+L+ + PLRITV+RT ADE VLLLV HHI WDD SW VFF +L+ AY+ Sbjct: 195 AQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRAD 254 Query: 200 INDPAAQFLSVEVLQNSAA---PSVADVGYWAETLRXXXXXXXXXGVSGA--NPCRRAQR 254 + L E ++A+ + AD+ YW + G +G RA R Sbjct: 255 LGAD----LGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAAR 310 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 LPA +RV A+ +P+MVLLAA+G LV RYT + DFLV+ PV R Sbjct: 311 ATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTED 370 Query: 315 ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 A+GYFGNT+ +R+ +S +F + R+ FAHQ + +DRVVRE NP+R R G Sbjct: 371 AIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR--RHGA 428 Query: 375 DLLVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ- 432 + + R+ F R+ GG G+ + L + LPL + D V VE E+ + Sbjct: 429 ERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEI 488 Query: 433 LSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 L L QML H+ L+D ALA P+ LS L ++ + + S GE + P T+V Sbjct: 489 LEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVD 548 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 V + TY +L+ +NRL W I QG G ED + + + S + Sbjct: 549 LVNEQTTRTPDATAV--VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPD 606 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPL 612 IV L V+K+GA Y+P+DP+YP +R+D+++ D + V+ P ++A SD P Sbjct: 607 LIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELA----GYRSDDP- 661 Query: 613 SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFS 672 +D+DR+RPLRP + AY+IYTSG+TG PKGVAV H +AE+ F E+ + DR LQ + Sbjct: 662 TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVA 721 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 S SFD S+A+IF TL GA++++P+P DI Y+ L+ G+T Sbjct: 722 SPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSL 781 Query: 733 XXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGAR 792 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V G G R Sbjct: 782 PGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTR 841 Query: 793 VVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP 852 +VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY R LTA+RF+ADPFNP Sbjct: 842 IVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP 901 Query: 853 GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEE 912 G R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I P V +VV + Sbjct: 902 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 961 Query: 913 -TEAGPMLAAYLVPAA-------AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSG 964 G L Y+ PAA VDL+ IRA AAA+PEYM+P A+ V+ EIP+T G Sbjct: 962 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 1021 Query: 965 KLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAAR 1024 K+DR ALP P + +R P+TATER + +F +L GR RVGA+DSFF LGGHSLLA + Sbjct: 1022 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 1081 Query: 1025 LVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 LVA +R FGVD+ VR IF+ T LA +D L +D ARP Sbjct: 1082 LVAAVRNAFGVDVGVREIFEFATVTALAGH------------IDTLDSDS-------ARP 1122 Query: 1085 GFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXR 1144 + + LS SQ+ +WF YR +G N+P A GP R Sbjct: 1123 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1182 Query: 1145 HEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESGPLL 1201 HE LRT + E GVP+QI+ P ++ VR + + +L R +VF E+ + Sbjct: 1183 HEILRTVYREIGGVPHQIIQP--PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPI 1240 Query: 1202 QANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADY 1261 +A LL P+ VL L+VHHI DH S ++F DL+ AYRAR P W LP+Q+ADY Sbjct: 1241 RAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1299 Query: 1262 AVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 +VWQ + G + DYW L GL E + D RP +L G+ V+F + AA Sbjct: 1300 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI 1359 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 R L ++ G TEFML QAA+AVVLHK GGG D+ +G+PVA R E QL+G F N+ Sbjct: 1360 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINI 1419 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 VVLR DL G+PTLR +L +R L A AHQ+LP +++VEA+NP R+LSRNPLF +++ Sbjct: 1420 VVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV 1479 Query: 1440 RGEDWALVPRDL---TG-RGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADL 1495 R + +P+D TG G+TT+ L F+ A L++ E VI +L Sbjct: 1480 REQ----MPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC-GDEYRGHVIYRTEL 1534 Query: 1496 YE 1497 YE Sbjct: 1535 YE 1536 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1682 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1741 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1742 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1785 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1590 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1647 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1648 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1689 Query: 922 YL 923 L Sbjct: 1690 IL 1691 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1667 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1725 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1726 GGIPLTARMVFEHPVLCELAA 1746 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 1046 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1105 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1106 TALAGHIDTLDSD 1118 >tr|A5WPZ5|A5WPZ5_MYCTF Tax_Id=336982 SubName: Full=Peptide synthetase mbtE;[Mycobacterium tuberculosis] Length = 1731 Score = 1068 bits (2763), Expect = 0.0 Identities = 631/1502 (42%), Positives = 845/1502 (56%), Gaps = 68/1502 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +A+ GL SS I P RLSDGQ RMWF+Q DP LNICV+YR+ G +D Sbjct: 23 LADRGL----SSAAQDIGPHTDDRLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLA 78 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RL AVN V RH ILRTTY V +G D+ GW + DLT L + ++E L Sbjct: 79 RLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVL 138 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EF PF+L+ + PLRITV+RT ADE VLLLV HHI WDD SW VFF +L+ AY+ Sbjct: 139 AQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRAD 198 Query: 200 INDPAAQFLSVEVLQNSAA---PSVADVGYWAETLRXXXXXXXXXGVSGA--NPCRRAQR 254 + L E ++A+ + AD+ YW + G +G RA R Sbjct: 199 LGAD----LGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAAR 254 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 LPA +RV A+ +P+MVLLAA+G LV RYT + DFLV+ PV R Sbjct: 255 ATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTED 314 Query: 315 ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 A+GYFGNT+ +R+ +S +F + R+ FAHQ + +DRVVRE NP+R R G Sbjct: 315 AIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR--RHGA 372 Query: 375 DLLVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ- 432 + + R+ F R+ GG G+ + L + LPL + D V VE E+ + Sbjct: 373 ERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEI 432 Query: 433 LSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 L L QML H+ L+D ALA P+ LS L ++ + + S GE + P T+V Sbjct: 433 LEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVD 492 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 V + TY +L+ +NRL W I QG G ED + + + S + Sbjct: 493 LVNEQTTRTPDATAV--VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPD 550 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPL 612 IV L V+K+GA Y+P+DP+YP +R+D+++ D + V+ P ++A SD P Sbjct: 551 LIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELA----GYRSDDP- 605 Query: 613 SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFS 672 +D+DR+RPLRP + AY+IYTSG+TG PKGVAV H +AE+ F E+ + DR LQ + Sbjct: 606 TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVA 665 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 S SFD S+A+IF TL GA++++P+P DI Y+ L+ G+T Sbjct: 666 SPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSL 725 Query: 733 XXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGAR 792 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V G G R Sbjct: 726 PGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTR 785 Query: 793 VVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP 852 +VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY R LTA+RF+ADPFNP Sbjct: 786 IVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP 845 Query: 853 GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEE 912 G R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I P V +VV + Sbjct: 846 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 905 Query: 913 -TEAGPMLAAYLVPAA-------AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSG 964 G L Y+ PAA VDL+ IRA AAA+PEYM+P A+ V+ EIP+T G Sbjct: 906 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 965 Query: 965 KLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAAR 1024 K+DR ALP P + +R P+TATER + +F +L GR RVGA+DSFF LGGHSLLA + Sbjct: 966 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 1025 Query: 1025 LVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 LVA +R FGVD+ VR IF+ T LA +D L +D ARP Sbjct: 1026 LVAAVRNAFGVDVGVREIFEFATVTALAGH------------IDTLDSDS-------ARP 1066 Query: 1085 GFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXR 1144 + + LS SQ+ +WF YR +G N+P A GP R Sbjct: 1067 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1126 Query: 1145 HEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESGPLL 1201 HE LRT + E GVP+QI+ P ++ VR + + +L R +VF E+ + Sbjct: 1127 HEILRTVYREIGGVPHQIIQP--PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPI 1184 Query: 1202 QANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADY 1261 +A LL P+ VL L+VHHI DH S ++F DL+ AYRAR P W LP+Q+ADY Sbjct: 1185 RAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1243 Query: 1262 AVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 +VWQ + G + DYW L GL E + D RP +L G+ V+F + AA Sbjct: 1244 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI 1303 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 R L ++ G TEFML QAA+AVVLHK GGG D+ +G+PVA R E QL+G F N+ Sbjct: 1304 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINI 1363 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 VVLR DL G+PTLR +L +R L A AHQ+LP +++VEA+NP R+LSRNPLF +++ Sbjct: 1364 VVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV 1423 Query: 1440 RGEDWALVPRDL---TG-RGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADL 1495 R + +P+D TG G+TT+ L F+ A L++ E VI +L Sbjct: 1424 REQ----MPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC-GDEYRGHVIYRTEL 1478 Query: 1496 YE 1497 YE Sbjct: 1479 YE 1480 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1626 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1685 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1686 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1729 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1534 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1591 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1592 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1633 Query: 922 YL 923 L Sbjct: 1634 IL 1635 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1611 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1669 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1670 GGIPLTARMVFEHPVLCELAA 1690 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 990 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1049 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1050 TALAGHIDTLDSD 1062 >tr|A4KJD0|A4KJD0_MYCTU Tax_Id=395095 SubName: Full=Peptide synthetase mbtE;[Mycobacterium tuberculosis str. Haarlem] Length = 1731 Score = 1068 bits (2763), Expect = 0.0 Identities = 631/1502 (42%), Positives = 845/1502 (56%), Gaps = 68/1502 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +A+ GL SS I P RLSDGQ RMWF+Q DP LNICV+YR+ G +D Sbjct: 23 LADRGL----SSAAQDIGPHTDDRLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLA 78 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RL AVN V RH ILRTTY V +G D+ GW + DLT L + ++E L Sbjct: 79 RLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVL 138 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EF PF+L+ + PLRITV+RT ADE VLLLV HHI WDD SW VFF +L+ AY+ Sbjct: 139 AQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRAD 198 Query: 200 INDPAAQFLSVEVLQNSAA---PSVADVGYWAETLRXXXXXXXXXGVSGA--NPCRRAQR 254 + L E ++A+ + AD+ YW + G +G RA R Sbjct: 199 LGAD----LGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAAR 254 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 LPA +RV A+ +P+MVLLAA+G LV RYT + DFLV+ PV R Sbjct: 255 ATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTED 314 Query: 315 ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 A+GYFGNT+ +R+ +S +F + R+ FAHQ + +DRVVRE NP+R R G Sbjct: 315 AIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR--RHGA 372 Query: 375 DLLVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ- 432 + + R+ F R+ GG G+ + L + LPL + D V VE E+ + Sbjct: 373 ERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEI 432 Query: 433 LSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 L L QML H+ L+D ALA P+ LS L ++ + + S GE + P T+V Sbjct: 433 LEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVD 492 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 V + TY +L+ +NRL W I QG G ED + + + S + Sbjct: 493 LVNEQTTRTPDATAV--VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPD 550 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPL 612 IV L V+K+GA Y+P+DP+YP +R+D+++ D + V+ P ++A SD P Sbjct: 551 LIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELA----GYRSDDP- 605 Query: 613 SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFS 672 +D+DR+RPLRP + AY+IYTSG+TG PKGVAV H +AE+ F E+ + DR LQ + Sbjct: 606 TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVA 665 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 S SFD S+A+IF TL GA++++P+P DI Y+ L+ G+T Sbjct: 666 SPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSL 725 Query: 733 XXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGAR 792 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V G G R Sbjct: 726 PGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTR 785 Query: 793 VVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP 852 +VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY R LTA+RF+ADPFNP Sbjct: 786 IVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP 845 Query: 853 GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEE 912 G R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I P V +VV + Sbjct: 846 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 905 Query: 913 -TEAGPMLAAYLVPAA-------AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSG 964 G L Y+ PAA VDL+ IRA AAA+PEYM+P A+ V+ EIP+T G Sbjct: 906 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 965 Query: 965 KLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAAR 1024 K+DR ALP P + +R P+TATER + +F +L GR RVGA+DSFF LGGHSLLA + Sbjct: 966 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 1025 Query: 1025 LVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 LVA +R FGVD+ VR IF+ T LA +D L +D ARP Sbjct: 1026 LVAAVRNAFGVDVGVREIFEFATVTALAGH------------IDTLDSDS-------ARP 1066 Query: 1085 GFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXR 1144 + + LS SQ+ +WF YR +G N+P A GP R Sbjct: 1067 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1126 Query: 1145 HEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESGPLL 1201 HE LRT + E GVP+QI+ P ++ VR + + +L R +VF E+ + Sbjct: 1127 HEILRTVYREIGGVPHQIIQP--PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPI 1184 Query: 1202 QANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADY 1261 +A LL P+ VL L+VHHI DH S ++F DL+ AYRAR P W LP+Q+ADY Sbjct: 1185 RAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1243 Query: 1262 AVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 +VWQ + G + DYW L GL E + D RP +L G+ V+F + AA Sbjct: 1244 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI 1303 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 R L ++ G TEFML QAA+AVVLHK GGG D+ +G+PVA R E QL+G F N+ Sbjct: 1304 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINI 1363 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 VVLR DL G+PTLR +L +R L A AHQ+LP +++VEA+NP R+LSRNPLF +++ Sbjct: 1364 VVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV 1423 Query: 1440 RGEDWALVPRDL---TG-RGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADL 1495 R + +P+D TG G+TT+ L F+ A L++ E VI +L Sbjct: 1424 REQ----MPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC-GDEYRGHVIYRTEL 1478 Query: 1496 YE 1497 YE Sbjct: 1479 YE 1480 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1626 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1685 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1686 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1729 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1534 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1591 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1592 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1633 Query: 922 YL 923 L Sbjct: 1634 IL 1635 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1611 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1669 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1670 GGIPLTARMVFEHPVLCELAA 1690 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 990 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1049 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1050 TALAGHIDTLDSD 1062 >tr|A2VKA6|A2VKA6_MYCTU Tax_Id=348776 SubName: Full=Peptide synthetase mbtE;[Mycobacterium tuberculosis C] Length = 1731 Score = 1068 bits (2763), Expect = 0.0 Identities = 631/1502 (42%), Positives = 845/1502 (56%), Gaps = 68/1502 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +A+ GL SS I P RLSDGQ RMWF+Q DP LNICV+YR+ G +D Sbjct: 23 LADRGL----SSAAQDIGPHTDDRLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLA 78 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 RL AVN V RH ILRTTY V +G D+ GW + DLT L + ++E L Sbjct: 79 RLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVL 138 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A EF PF+L+ + PLRITV+RT ADE VLLLV HHI WDD SW VFF +L+ AY+ Sbjct: 139 AQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRAD 198 Query: 200 INDPAAQFLSVEVLQNSAA---PSVADVGYWAETLRXXXXXXXXXGVSGA--NPCRRAQR 254 + L E ++A+ + AD+ YW + G +G RA R Sbjct: 199 LGAD----LGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAAR 254 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 LPA +RV A+ +P+MVLLAA+G LV RYT + DFLV+ PV R Sbjct: 255 ATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTED 314 Query: 315 ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 A+GYFGNT+ +R+ +S +F + R+ FAHQ + +DRVVRE NP+R R G Sbjct: 315 AIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR--RHGA 372 Query: 375 DLLVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ- 432 + + R+ F R+ GG G+ + L + LPL + D V VE E+ + Sbjct: 373 ERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEI 432 Query: 433 LSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 L L QML H+ L+D ALA P+ LS L ++ + + S GE + P T+V Sbjct: 433 LEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVD 492 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 V + TY +L+ +NRL W I QG G ED + + + S + Sbjct: 493 LVNEQTTRTPDATAV--VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPD 550 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPL 612 IV L V+K+GA Y+P+DP+YP +R+D+++ D + V+ P ++A SD P Sbjct: 551 LIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELA----GYRSDDP- 605 Query: 613 SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFS 672 +D+DR+RPLRP + AY+IYTSG+TG PKGVAV H +AE+ F E+ + DR LQ + Sbjct: 606 TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVA 665 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 S SFD S+A+IF TL GA++++P+P DI Y+ L+ G+T Sbjct: 666 SPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSL 725 Query: 733 XXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGAR 792 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V G G R Sbjct: 726 PGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTR 785 Query: 793 VVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP 852 +VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY R LTA+RF+ADPFNP Sbjct: 786 IVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP 845 Query: 853 GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEE 912 G R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I P V +VV + Sbjct: 846 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 905 Query: 913 -TEAGPMLAAYLVPAA-------AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSG 964 G L Y+ PAA VDL+ IRA AAA+PEYM+P A+ V+ EIP+T G Sbjct: 906 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 965 Query: 965 KLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAAR 1024 K+DR ALP P + +R P+TATER + +F +L GR RVGA+DSFF LGGHSLLA + Sbjct: 966 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 1025 Query: 1025 LVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 LVA +R FGVD+ VR IF+ T LA +D L +D ARP Sbjct: 1026 LVAAVRNAFGVDVGVREIFEFATVTALAGH------------IDTLDSDS-------ARP 1066 Query: 1085 GFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXR 1144 + + LS SQ+ +WF YR +G N+P A GP R Sbjct: 1067 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1126 Query: 1145 HEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESGPLL 1201 HE LRT + E GVP+QI+ P ++ VR + + +L R +VF E+ + Sbjct: 1127 HEILRTVYREIGGVPHQIIQP--PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPI 1184 Query: 1202 QANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADY 1261 +A LL P+ VL L+VHHI DH S ++F DL+ AYRAR P W LP+Q+ADY Sbjct: 1185 RAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1243 Query: 1262 AVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 +VWQ + G + DYW L GL E + D RP +L G+ V+F + AA Sbjct: 1244 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI 1303 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 R L ++ G TEFML QAA+AVVLHK GGG D+ +G+PVA R E QL+G F N+ Sbjct: 1304 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINI 1363 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 VVLR DL G+PTLR +L +R L A AHQ+LP +++VEA+NP R+LSRNPLF +++ Sbjct: 1364 VVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV 1423 Query: 1440 RGEDWALVPRDL---TG-RGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADL 1495 R + +P+D TG G+TT+ L F+ A L++ E VI +L Sbjct: 1424 REQ----MPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC-GDEYRGHVIYRTEL 1478 Query: 1496 YE 1497 YE Sbjct: 1479 YE 1480 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1626 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1685 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1686 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1729 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1534 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1591 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1592 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1633 Query: 922 YL 923 L Sbjct: 1634 IL 1635 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1611 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1669 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1670 GGIPLTARMVFEHPVLCELAA 1690 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 990 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1049 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1050 TALAGHIDTLDSD 1062 >tr|A4T2D0|A4T2D0_MYCGI Tax_Id=350054 SubName: Full=Amino acid adenylation domain;[Mycobacterium gilvum] Length = 1762 Score = 1067 bits (2760), Expect = 0.0 Identities = 619/1493 (41%), Positives = 851/1493 (56%), Gaps = 55/1493 (3%) Query: 20 IAESGLAAEQSSDQPGICPGE-RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDE 78 +A SGL + ++ + R +DGQ+RMWF+ ++DP V LN+C++YR++G VD Sbjct: 18 LAGSGLREQDPAEPVAVAADPARGEFTDGQKRMWFVHSVDPSGVLLNVCLSYRISGEVDL 77 Query: 79 DRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIES 138 RLH AV V RH +LRTT+ D GEP + DD+ GW +D++ L E ++E Sbjct: 78 ARLHDAVTAVARRHPVLRTTFAADEAGEPQRTVHDDLLPGWTVQDISELSEHARRLRLEV 137 Query: 139 LAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDL 198 LA EFG PFDL E PLRITV RT E ++LLVVHHI WDD W VFF +L+ AY Sbjct: 138 LAQREFGTPFDLATESPLRITVARTAPAEYIMLLVVHHIAWDDGCWRVFFADLTRAYTGA 197 Query: 199 PINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSG-ANPCR-RAQRRV 256 + A + S D+ +W + G G A P R +R Sbjct: 198 ELGPTPAPVVEPPT-------SDEDLRFWRSAMTDLPEPLELPGPHGSAVPTTWRCRRVT 250 Query: 257 RPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL 316 L A RV AR+ A+P+MV+LAA+G L+ RYT A D L++ PV R + + Sbjct: 251 ATLSADTVERVRVAAREAGATPYMVMLAAFGALLHRYTHADDVLIASPVLLRGPDSEDVI 310 Query: 317 GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDL 376 GY GN+ ++R+ + TFT ++ R+ L FAHQ V +DRVVRE N +R R G + Sbjct: 311 GYHGNSAVMRLRPQPMQTFTELLSRTRDFALDAFAHQQVNLDRVVRELNLDR--RHGAER 368 Query: 377 LVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ-LS 434 + R+ F R+ GG + GV R+ L LPL L + L VE E+ + L Sbjct: 369 MTRVSFGFREPDGGGFSPPGVTCRRAELRGQITQLPLGLMVELHESGAVVEAEFLVEVLD 428 Query: 435 SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 LV QML HY+ L++ A+A+P+ LS L+++ + + + SHG ++PA T+ + Sbjct: 429 DTLVTQMLDHYVVLLEAAVAQPDTVLSRLELMDGDDAEWLRRVSHGPEFDVPAATIGELI 488 Query: 495 XXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFI 554 V + TY E++ ANR+A W IGQG G ED + + M S E + Sbjct: 489 EARTDLTPDTVAV--VYEGRRYTYREINESANRVAHWLIGQGIGAEDRVAVLMDRSPELL 546 Query: 555 VAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSD 614 + L ++KAGA YLP+DP+YP +R+ ++++D+ P VI P + +D P +D Sbjct: 547 ITALGIIKAGAVYLPVDPSYPQDRMSFVLSDSDPTLVIREPVAGLD----GHRTDNP-TD 601 Query: 615 SDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSV 674 R+RPLRP + AY+IYTSGSTG+PKGV V H +AE+ F E+ ++ DR LQ +S Sbjct: 602 DVRVRPLRPENAAYLIYTSGSTGQPKGVPVPHRPVAEYFVWFKDEYEISESDRLLQVASP 661 Query: 675 SFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXX 734 SFD S+ +IF TL G +L++PKPD D++Y+ +L+ R G+T Sbjct: 662 SFDVSIGEIFGTLACGGRLVIPKPDGLTDVAYLTELLQREGITAMHFVPSLLGLFLSLPG 721 Query: 735 XXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVV 794 QWR L VP+GGEALPGE+ADRF FDA L N YGPTE ++ +T V G+ G+R+V Sbjct: 722 VNQWRTLERVPIGGEALPGELADRFHATFDALLHNFYGPTETIINTTRYKVEGTQGSRIV 781 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGM 854 PIG P N ++LD+ L PVP IGE+Y+GG +ARGY RP LTA+RF+ADPF G Sbjct: 782 PIGTPKINTTVHLLDDALRPVPVGAIGEIYIGGGHVARGYHRRPALTAERFVADPFTVGG 841 Query: 855 RLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE 914 RLYR+GDL RRN G+LEFVGRAD+QVKIRGFRIELGEV + I+ P+V +V+ ++ Sbjct: 842 RLYRSGDLARRNADGDLEFVGRADDQVKIRGFRIELGEVAAAISVDPSVGQAVVLGQDLP 901 Query: 915 A-GPMLAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALP 972 G L Y+ PAA + VDL +R AAA+P+YM P + V+ EIP+T GK+DR ALP Sbjct: 902 GLGMSLVGYVTPAAGEDVDLARVRERVAAALPDYMTPAGYVVLDEIPITAHGKIDRAALP 961 Query: 973 APTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 P YREP+T TE+ + +F++L G RVG +DSFF LGGHSLLA +LV+ +R+ Sbjct: 962 LPEITTATDYREPQTETEQHLAQLFSELLGVARVGVDDSFFELGGHSLLATKLVSAVRSR 1021 Query: 1033 FGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAA-DDMPLDPKRARPGFVKSAR 1091 GVD+ +R IF+ G ARL ER +D LAA PL RP + Sbjct: 1022 CGVDMEIREIFE----LGTVARLAER--------VDELAAGGSAPL-----RPRLLAVPH 1064 Query: 1092 PQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTN 1151 P+S +QL WFQYRIEG N+P A RF GP RHE+LRT Sbjct: 1065 DGPAPMSAAQLRQWFQYRIEGPGPVNNVPFAARFAGPCDVDALIEAVRDVVNRHESLRTT 1124 Query: 1152 FDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVST--QLRRHVFTPESGPLLQANLLVLG 1209 F E +GVPYQ+V+ R D+ V RR VF E+ ++ +L + Sbjct: 1125 FCEIDGVPYQLVNAPDPGFPVRRDSGPDDAWLVGALDDERRRVFDLENQWPIRVAVLSI- 1183 Query: 1210 PDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF 1269 P H L ++VHHI +DH S ++F +L+ AYRAR AP W LP+Q+ADYA WQ Sbjct: 1184 PGEHALSVVVHHIAADHWSGGVLFTELLTAYRARRAGEAPTWAPLPVQYADYAAWQSALL 1243 Query: 1270 ESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLA 1327 + G + YW L GL E + D RP V + V+F++ AA R L L+ Sbjct: 1244 ADDSGIVAAQRRYWTQQLEGLSAETGLQPDLVRPSVPSGAADAVEFTLDAAIREKLVTLS 1303 Query: 1328 ERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLS 1387 GATEFML QAA+AV L+K G G DI LG+PVA R E QL+G F N++VLR DL Sbjct: 1304 REVGATEFMLLQAAVAVTLYKAGEGPDIPLGTPVAGRTESELDQLIGFFINILVLRNDLR 1363 Query: 1388 GDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALV 1447 +P+LR + SR+ L A AHQ+LP +++V+A++P R+LSRNPLF +++ R E + Sbjct: 1364 DNPSLRDVGFRSREMALAAYAHQDLPFDQVVDAVSPVRSLSRNPLFGVVVHVREE----L 1419 Query: 1448 PRD---LTGR-GETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLY 1496 P+D TG GETT L F++A L++ +G VI +LY Sbjct: 1420 PQDRVIATGSDGETTFTALEPTFDMAHADLSVNFFAGGNGYRG-HVIYRTELY 1471 Score = 80.5 bits (197), Expect = 2e-12 Identities = 46/117 (39%), Positives = 68/117 (58%), Gaps = 10/117 (8%) Query: 1558 ETERRLTAMLEELL----EITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFE 1613 +TE+ L ML ++L + TGI R +++F LGGDSI+A++ +A+A GL MVFE Sbjct: 1651 DTEKALVGMLADVLVEVHDGTGIGRFDDFFELGGDSILAVQLAARAKQAGLRLSARMVFE 1710 Query: 1614 HMTIAELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS 1670 H + +LA A+D A V + + PMSASGL P+ LA ++ SW + S Sbjct: 1711 HPVVHDLAVALDTAKTPEVADV------RHDPMSASGLTPEELAMVATSWAAEQDGS 1761 Score = 70.1 bits (170), Expect = 3e-09 Identities = 81/316 (25%), Positives = 117/316 (37%), Gaps = 60/316 (18%) Query: 743 HVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRN 802 HV E A+RFAG+ A + E V + P+ P Sbjct: 1463 HVIYRTELYTRATAERFAGWLSAVITAFADDPERHVDDVVIAE---------PVR-PGDG 1512 Query: 803 VYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDL 862 A +LD HPVP V+ +++ Y G P R GD Sbjct: 1513 AEAVLLDGAGHPVPVGVVADVH---------YAGAPD------------------RRGDR 1545 Query: 863 VRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAY 922 R G L++V R D ++E+ + P V V E + Y Sbjct: 1546 ARWTEDGRLQYVERVDH------------DLEAALAAVPGVAAAAVRTWEIGHRTAVVGY 1593 Query: 923 LVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPT---PIAT 979 +VPA D AAV P + V+ +P T RRALPAP P Sbjct: 1594 VVPAEPVDDPASFAETVRAAVAPESAPTSITVLDALPAT------RRALPAPRVGGPSEP 1647 Query: 980 RRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTV 1039 R + E A + + ++ +G D FF LGG S+LA +L A+ + + G+ L+ Sbjct: 1648 AR-TDTEKALVGMLADVLVEVHDGTGIGRFDDFFELGGDSILAVQLAARAK-QAGLRLSA 1705 Query: 1040 RTIFDAPTPAGLAARL 1055 R +F+ P LA L Sbjct: 1706 RMVFEHPVVHDLAVAL 1721 Score = 46.2 bits (108), Expect = 0.040 Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 6/109 (5%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMT 1616 ETE+ L + ELL + + D+++F LGG S++A K SA G+ +FE T Sbjct: 977 ETEQHLAQLFSELLGVARVGVDDSFFELGGHSLLATKLVSAVRSRCGVDMEIREIFELGT 1036 Query: 1617 IAELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 +A LA VD E P + G AP + A+L W Q Sbjct: 1037 VARLAERVD----ELAAGGSAPLRPRLLAVPHDGPAPMSAAQL-RQWFQ 1080 >tr|A1TBS6|A1TBS6_MYCVP Tax_Id=350058 SubName: Full=Amino acid adenylation domain;[Mycobacterium vanbaalenii] Length = 1721 Score = 1061 bits (2743), Expect = 0.0 Identities = 617/1505 (40%), Positives = 831/1505 (55%), Gaps = 88/1505 (5%) Query: 22 ESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRL 81 E GL+A + +P G+ L++GQ RMWF+ DP LN+C++YRL+G +D RL Sbjct: 24 ERGLSAGTDTAEPA---GDTDVLTEGQLRMWFVHNADPSGALLNVCLSYRLSGEIDVARL 80 Query: 82 HTAVNDVVARHAILRTTYGVDT-----EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQI 136 H AV V RH +LRTTY ++ G P + GW DL+ L E ++ Sbjct: 81 HDAVGAVARRHRVLRTTYRTESTAAGDSGMPVPTVHTGLMPGWAEHDLSELSERARGLRL 140 Query: 137 ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN 196 E LA EFGRPFDL E PLRITVIRT E V+LLV HHI WDD SWEVFF +L+ AY Sbjct: 141 EVLAQREFGRPFDLGAESPLRITVIRTAPAEYVMLLVAHHIAWDDASWEVFFDDLTGAYV 200 Query: 197 DLPINDPAAQFLSVEVLQNSAAPSVA-------DVGYWAETLRXXXXXXXXXGVSG-ANP 248 E L+ + P VA DV YW + G +G A P Sbjct: 201 G-------------EKLRPARRPVVAAGGSDEDDVAYWRAVMADPPEPLELPGPTGSAVP 247 Query: 249 CR-RAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTE 307 R+QR L RV A + A+P+ VLLA +GVL+ RY+ DFLV+ PV Sbjct: 248 TSWRSQRTTLRLDGETARRVTALADEVGATPYAVLLAVFGVLIHRYSHVDDFLVATPVLN 307 Query: 308 RSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPE 367 R+G +GYFGNT+ +R+ TF + + R+T L FAHQ VG+DR+VRE NP+ Sbjct: 308 RNGDTDDVIGYFGNTVAMRLRPHPAMTFRDLLTQTRDTALGAFAHQRVGLDRMVRELNPD 367 Query: 368 RMGRDGMDLLVRLGFNMR-KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE 426 R R G + + R+ F R + G GV + L + HLPL + + DPD+V VE Sbjct: 368 R--RHGAERMTRVSFGFRSRDRFGFTPPGVTCERADLRSHLTHLPLGIMVEFDPDEVVVE 425 Query: 427 FEYQQQLSSV-LVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM 485 E+ ++ L Q+L HY L+ AL +P+ LS L ++G + + + A S G + Sbjct: 426 LEHLVEIIEPGLARQLLDHYAVLIRSALDDPDTTLSGLQLMGDDDLEWLRAVSVGPTFDT 485 Query: 486 PATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGL 545 P T+ V + TY E++ ANR+A W IG+ G ED + + Sbjct: 486 PPATITDLIEAQVRRSPDGTAV--VYEGRHYTYREINEAANRVAHWLIGEDVGAEDRVAV 543 Query: 546 RMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAA 605 + S E +V L VLKAGA Y+PIDPAYP +R+++++ D + V+ P + A Sbjct: 544 MLDKSPELVVTALGVLKAGAVYVPIDPAYPQDRLEFILGDCDAKVVVREPVTGLDGYRAD 603 Query: 606 DNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAE 665 D D +DR RP+ P + AY+IYTSGSTG PKGV V H +AE+ F ++ + A Sbjct: 604 DPGD-----NDRRRPVGPYNTAYLIYTSGSTGLPKGVPVPHRPVAEYFVWFKGDYRVDAG 658 Query: 666 DRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXX 725 DR LQ +S SFD S+A++F TL GA+L++ +P DI Y+ L+ G+T Sbjct: 659 DRMLQVASPSFDISIAEVFGTLACGARLVIHRPGGLNDIGYLTALLRDEGITAMHFVPSL 718 Query: 726 XXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVV 785 QWR L+ VP+GGEALPGEVAD+F FDA L N YGPTE V+ +T V Sbjct: 719 LGLFLSLPGVNQWRTLQRVPIGGEALPGEVADKFRATFDALLHNFYGPTETVINATRFKV 778 Query: 786 TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 G G R+VPIG P N ++LD+ L PVP IGE+Y+GG+ +ARGY RP LTA+RF Sbjct: 779 EGRQGTRIVPIGKPKINTAIHILDDALQPVPVGSIGEIYIGGTHVARGYHHRPGLTAERF 838 Query: 846 IADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRH 905 +ADPF PG R+YR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + IT P+V Sbjct: 839 VADPFTPGARMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAITVDPSVGQ 898 Query: 906 CLVVAEE-TEAGPMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVS 963 +VV + G L AYL PA A VD++ IR AAA+PEYM P A+ V+ EIP+T Sbjct: 899 AVVVVSDLPNLGKSLVAYLTPADGAGVDVDRIRTRVAAALPEYMTPAAYVVVDEIPITAH 958 Query: 964 GKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAA 1023 GK+DR ALP P T +REP TE + +FA+L G ++VGA+DSFF LGGHSLLA Sbjct: 959 GKIDRAALPEPEIAPTTEFREPAAGTEAHLAQLFAELLGHEKVGADDSFFDLGGHSLLAT 1018 Query: 1024 RLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRAR 1083 +LVA++RA FGVD+ VR IF+ T A LAA L R R Sbjct: 1019 KLVAELRAGFGVDVEVRDIFENATIARLAAHLDTMGRATI----------------GTRR 1062 Query: 1084 PGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXX 1143 P V + PLS SQL +WF YRIEG N+P A R GP Sbjct: 1063 PRLVAAPLDGPAPLSSSQLRSWFGYRIEGRSPVNNIPFAARLTGPCDVDAFVAAIRDVVE 1122 Query: 1144 RHEALRTNFDEHEGVPYQIVHPSRTVQL-AVRAIDQDEFDDVSTQLRRHVFTPESGPLLQ 1202 RH LRT + E +GVPYQIV+P V + R + + R+H F E ++ Sbjct: 1123 RHAILRTTYREIDGVPYQIVNPISDVPVRRARGEGEQWLQAELDRERKHTFDLEEDWPIR 1182 Query: 1203 ANLLVLG----------------------PDTHVLLLIVHHIVSDHASLEIVFDDLIVAY 1240 A + +G HVL +++HHI DH S ++F DL+ AY Sbjct: 1183 AAVFTVGAVSPASDGGAVSPASDGGAVDPASDHVLSVVIHHIAGDHWSGGVLFTDLVAAY 1242 Query: 1241 RARLQHNAPQWDILPIQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDR 1298 RAR P W LP+Q+ DY WQ + G + +YW LA P E + + Sbjct: 1243 RARKAGERPTWAPLPVQYTDYGAWQAELLSDDTGIAGPQREYWIRQLADAPVESGLPLEF 1302 Query: 1299 ARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALG 1358 +RPR+ +G+ V+F++ R +T+L G TEFML QAA+AV L K+GGG DI LG Sbjct: 1303 SRPRLPSGKGDAVEFTIDGQVRRQITELCRELGITEFMLLQAAVAVTLAKVGGGLDIPLG 1362 Query: 1359 SPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLV 1418 +PVA R E QLVG F N VVLR DL G+PTLR +L+ +R+ L A ++Q++P E++V Sbjct: 1363 TPVAGRSEAELEQLVGFFVNFVVLRNDLRGNPTLREVLIRAREMALSAYSNQDVPFEQVV 1422 Query: 1419 EALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMS 1478 EA+NPPR L+RNPLFQ +++ R + +P+ +T L F++A L++ Sbjct: 1423 EAVNPPRTLARNPLFQVVVHVREQ----LPQRQMIDTDTEFTALEPTFDIAQADLSLNFL 1478 Query: 1479 VTPSG 1483 +G Sbjct: 1479 ADGTG 1483 Score = 108 bits (271), Expect = 5e-21 Identities = 128/481 (26%), Positives = 187/481 (38%), Gaps = 70/481 (14%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q R WF ++ NI A RL G D D A+ DVV RHAILRTTY + Sbjct: 1076 LSSSQLRSWFGYRIEGRSPVNNIPFAARLTGPCDVDAFVAAIRDVVERHAILRTTYR-EI 1134 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 +G PYQ+ + +V RR E+ +++ E FDL + P+R V Sbjct: 1135 DGVPYQIVNPISDVPVRRA------RGEGEQWLQAELDRERKHTFDLEEDWPIRAAVFTV 1188 Query: 164 RA----------------------DELVLLLVVHHICWDDDSWEVFFGELSAAYN----- 196 A + VL +V+HHI D S V F +L AAY Sbjct: 1189 GAVSPASDGGAVSPASDGGAVDPASDHVLSVVIHHIAGDHWSGGVLFTDLVAAYRARKAG 1248 Query: 197 ------DLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCR 250 LP+ E+L + + YW L V P Sbjct: 1249 ERPTWAPLPVQYTDYGAWQAELLSDDTGIAGPQREYWIRQLADAP-------VESGLPLE 1301 Query: 251 RAQRRVRPLPAGLFSRVE------------DFARKCSASPFMVLLAAYGVLVRRYTGASD 298 ++ R LP+G VE + R+ + FM+L AA V + + G D Sbjct: 1302 FSRPR---LPSGKGDAVEFTIDGQVRRQITELCRELGITEFMLLQAAVAVTLAKVGGGLD 1358 Query: 299 FLVSVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGI 357 + PV RS A L G+F N ++LR R T + RE L+ +++Q V Sbjct: 1359 IPLGTPVAGRSEAELEQLVGFFVNFVVLRNDLRGNPTLREVLIRAREMALSAYSNQDVPF 1418 Query: 358 DRVVREANPER-MGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAV--AAHLPLSL 414 ++VV NP R + R+ + +V ++R+ + L A LSL Sbjct: 1419 EQVVEAVNPPRTLARNPLFQVV---VHVREQLPQRQMIDTDTEFTALEPTFDIAQADLSL 1475 Query: 415 TIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDS 473 D Y+ +L + + L +L V A + P+R L +DI+ A ER Sbjct: 1476 NFLADGTGYRGYLIYRPELYARRTIERLGRWLPRVVAAFVDTPDRALGDVDIVSAEERQR 1535 Query: 474 V 474 V Sbjct: 1536 V 1536 Score = 89.4 bits (220), Expect = 4e-15 Identities = 48/106 (45%), Positives = 67/106 (63%), Gaps = 4/106 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ++ER L A+L ELL + R +++F LGGDS++A++ +A+A GL MVFEH + Sbjct: 1616 DSERALAALLSELLATEEVGRHDDFFGLGGDSVLAVQLAARARDTGLDLTARMVFEHPRL 1675 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 AELAAA+D+ G A P + PMS SGL+ D LA L+ASW Sbjct: 1676 AELAAALDSGAG----AAAEQPDTHHAPMSVSGLSEDELAALTASW 1717 Score = 65.1 bits (157), Expect = 8e-08 Identities = 33/74 (44%), Positives = 48/74 (64%), Gaps = 1/74 (1%) Query: 982 YREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRT 1041 + EP T +ER + ++ ++L + VG D FFGLGG S+LA +L A+ R + G+DLT R Sbjct: 1610 FEEPRTDSERALAALLSELLATEEVGRHDDFFGLGGDSVLAVQLAARAR-DTGLDLTARM 1668 Query: 1042 IFDAPTPAGLAARL 1055 +F+ P A LAA L Sbjct: 1669 VFEHPRLAELAAAL 1682 Score = 43.9 bits (102), Expect = 0.20 Identities = 32/98 (32%), Positives = 47/98 (47%), Gaps = 5/98 (5%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTI 1617 TE L + ELL + D+++F LGG S++A K A+ A G+ +FE+ TI Sbjct: 984 TEAHLAQLFAELLGHEKVGADDSFFDLGGHSLLATKLVAELRAGFGVDVEVRDIFENATI 1043 Query: 1618 AELAAAVDAANGEPVVEADP----PPAQEYTPMSASGL 1651 A LAA +D + P P P+S+S L Sbjct: 1044 ARLAAHLDTMGRATIGTRRPRLVAAPLDGPAPLSSSQL 1081 >tr|Q7TYQ7|Q7TYQ7_MYCBO Tax_Id=1765 (mbtE)SubName: Full=PEPTIDE SYNTHETASE MBTE (PEPTIDE SYNTHASE);[Mycobacterium bovis] Length = 1682 Score = 1053 bits (2724), Expect = 0.0 Identities = 617/1471 (41%), Positives = 829/1471 (56%), Gaps = 64/1471 (4%) Query: 51 MWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQV 110 MWF+Q DP LNICV+YR+ G +D RL AVN V RH ILRTTY V +G Sbjct: 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query: 111 FSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVL 170 D+ GW + DLT L + ++E LA EF PF+L+ + PLRITV+RT ADE VL Sbjct: 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query: 171 LLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAA---PSVADVGYW 227 LLV HHI WDD SW VFF +L+ AY+ + L E ++A+ + AD+ YW Sbjct: 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD----LGPEHRPSAASGPDTTEADLNYW 176 Query: 228 AETLRXXXXXXXXXGVSGA--NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAA 285 + G +G RA R LPA +RV A+ +P+MVLLAA Sbjct: 177 RAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 Query: 286 YGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRET 345 +G LV RYT + DFLV+ PV R A+GYFGNT+ +R+ +S +F + R+ Sbjct: 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 Query: 346 CLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLG 404 FAHQ + +DRVVRE NP+R R G + + R+ F R+ GG G+ + L Sbjct: 297 ASGAFAHQRINLDRVVRELNPDR--RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLR 354 Query: 405 AVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSL 463 + LPL + D V VE E+ + L L QML H+ L+D ALA P+ LS L Sbjct: 355 SNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGL 414 Query: 464 DILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHR 523 ++ + + S GE + P T+V V + TY +L+ Sbjct: 415 ALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV--VYEGQHFTYHDLNE 472 Query: 524 RANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLI 583 +NRL W I QG G ED + + + S + IV L V+K+GA Y+P+DP+YP +R+D+++ Sbjct: 473 ASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFIL 532 Query: 584 TDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVA 643 D + V+ P ++A SD P +D+DR+RPLRP + AY+IYTSG+TG PKGVA Sbjct: 533 ADCDAKLVLRTPVRELA----GYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGVA 587 Query: 644 VSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGD 703 V H +AE+ F E+ + DR LQ +S SFD S+A+IF TL GA++++P+P D Sbjct: 588 VPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTD 647 Query: 704 ISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYF 763 I Y+ L+ G+T QWR L+ VP+GGE LPGEVAD+F F Sbjct: 648 IGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 Query: 764 DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGEL 823 DA L N YGPTE V+ ++ V G G R+VPIG P N ++LD+ L PVP VIGE+ Sbjct: 708 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEI 767 Query: 824 YLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKI 883 Y+GG+ +A GY R LTA+RF+ADPFNPG R+YR+GDL RRN G++EFVGRADEQVKI Sbjct: 768 YIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKI 827 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEE-TEAGPMLAAYLVPAA-------AQVDLEEI 935 RGFRIELG+V + I P V +VV + G L Y+ PAA VDL+ I Sbjct: 828 RGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRI 887 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 RA AAA+PEYM+P A+ V+ EIP+T GK+DR ALP P + +R P+TATER + Sbjct: 888 RARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQ 947 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +F +L GR RVGA+DSFF LGGHSLLA +LVA +R FGVD+ VR IF+ T LA Sbjct: 948 LFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH- 1006 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 +D L +D ARP + + LS SQ+ +WF YR +G Sbjct: 1007 -----------IDTLDSDS-------ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNA 1048 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRA 1175 N+P A GP RHE LRT + E GVP+QI+ P ++ VR Sbjct: 1049 VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP--PAEVPVRC 1106 Query: 1176 IDQDEFDDVSTQL---RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIV 1232 + + +L R +VF E+ ++A LL P+ VL L+VHHI DH S ++ Sbjct: 1107 AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVL 1165 Query: 1233 FDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPD 1290 F DL+ AYRAR P W LP+Q+ADY+VWQ + G + DYW L GL Sbjct: 1166 FTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAG 1225 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 E + D RP +L G+ V+F + AA R L ++ G TEFML QAA+AVVLHK G Sbjct: 1226 ETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAG 1285 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 GG D+ +G+PVA R E QL+G F N+VVLR DL G+PTLR +L +R L A AHQ Sbjct: 1286 GGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQ 1345 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---TG-RGETTVVPLPVNF 1466 +LP +++VEA+NP R+LSRNPLF +++ R + +P+D TG G+TT+ L F Sbjct: 1346 DLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPTF 1401 Query: 1467 EVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 + A L++ E VI +LYE Sbjct: 1402 DAAQADLSVNFFAC-GDEYRGHVIYRTELYE 1431 Score = 126 bits (317), Expect = 2e-26 Identities = 129/465 (27%), Positives = 193/465 (41%), Gaps = 45/465 (9%) Query: 43 RLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVD 102 RLS Q R WF D + NI A L G D + A+ DVVARH ILRT Y + Sbjct: 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-E 1087 Query: 103 TEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 G P+Q+ EV R + + +E G FDL + P+R ++ Sbjct: 1088 IGGVPHQIIQPPAEVP------VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS 1141 Query: 163 TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVE 211 T ++ VL LVVHHI D S V F +L AY LP+ Sbjct: 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query: 212 VLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR-----------PLP 260 +L + A YW L G++G R R L Sbjct: 1201 LLDDGAGIVGPQRDYWIRQL---------GGLAGETGLRPDFPRPALLSGAGDAVEFRLG 1251 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A + ++ +R + FM+L AA V++ + G D + PV RS A L G+F Sbjct: 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-DLL 377 N ++LR R T + R+ LA +AHQ + D+VV NP+R + R+ + D++ Sbjct: 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV 1371 Query: 378 VRLGFNM-RKSAGGLALDG-VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSS 435 V + M + DG +R L AA LS+ D+ Y+ +L Sbjct: 1372 VHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYE 1431 Query: 436 VLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQSH 479 Q +L V +A A+ P++PL ++++ A R +L +S+ Sbjct: 1432 RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1577 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1636 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1637 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1680 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1542 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1543 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1584 Query: 922 YL 923 L Sbjct: 1585 IL 1586 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1620 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1621 GGIPLTARMVFEHPVLCELAA 1641 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 941 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1000 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1001 TALAGHIDTLDSD 1013 >tr|O86329|O86329_MYCTU Tax_Id=1773 (mbtE)SubName: Full=PEPTIDE SYNTHETASE MBTE (PEPTIDE SYNTHASE);[Mycobacterium tuberculosis] Length = 1682 Score = 1053 bits (2724), Expect = 0.0 Identities = 617/1471 (41%), Positives = 829/1471 (56%), Gaps = 64/1471 (4%) Query: 51 MWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQV 110 MWF+Q DP LNICV+YR+ G +D RL AVN V RH ILRTTY V +G Sbjct: 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query: 111 FSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVL 170 D+ GW + DLT L + ++E LA EF PF+L+ + PLRITV+RT ADE VL Sbjct: 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query: 171 LLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAA---PSVADVGYW 227 LLV HHI WDD SW VFF +L+ AY+ + L E ++A+ + AD+ YW Sbjct: 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD----LGPEHRPSAASGPDTTEADLNYW 176 Query: 228 AETLRXXXXXXXXXGVSGA--NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAA 285 + G +G RA R LPA +RV A+ +P+MVLLAA Sbjct: 177 RAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 Query: 286 YGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRET 345 +G LV RYT + DFLV+ PV R A+GYFGNT+ +R+ +S +F + R+ Sbjct: 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 Query: 346 CLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLG 404 FAHQ + +DRVVRE NP+R R G + + R+ F R+ GG G+ + L Sbjct: 297 ASGAFAHQRINLDRVVRELNPDR--RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLR 354 Query: 405 AVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSL 463 + LPL + D V VE E+ + L L QML H+ L+D ALA P+ LS L Sbjct: 355 SNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGL 414 Query: 464 DILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHR 523 ++ + + S GE + P T+V V + TY +L+ Sbjct: 415 ALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV--VYEGQHFTYHDLNE 472 Query: 524 RANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLI 583 +NRL W I QG G ED + + + S + IV L V+K+GA Y+P+DP+YP +R+D+++ Sbjct: 473 ASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFIL 532 Query: 584 TDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVA 643 D + V+ P ++A SD P +D+DR+RPLRP + AY+IYTSG+TG PKGVA Sbjct: 533 ADCDAKLVLRTPVRELA----GYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGVA 587 Query: 644 VSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGD 703 V H +AE+ F E+ + DR LQ +S SFD S+A+IF TL GA++++P+P D Sbjct: 588 VPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTD 647 Query: 704 ISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYF 763 I Y+ L+ G+T QWR L+ VP+GGE LPGEVAD+F F Sbjct: 648 IGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 Query: 764 DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGEL 823 DA L N YGPTE V+ ++ V G G R+VPIG P N ++LD+ L PVP VIGE+ Sbjct: 708 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEI 767 Query: 824 YLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKI 883 Y+GG+ +A GY R LTA+RF+ADPFNPG R+YR+GDL RRN G++EFVGRADEQVKI Sbjct: 768 YIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKI 827 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEE-TEAGPMLAAYLVPAA-------AQVDLEEI 935 RGFRIELG+V + I P V +VV + G L Y+ PAA VDL+ I Sbjct: 828 RGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRI 887 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 RA AAA+PEYM+P A+ V+ EIP+T GK+DR ALP P + +R P+TATER + Sbjct: 888 RARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQ 947 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +F +L GR RVGA+DSFF LGGHSLLA +LVA +R FGVD+ VR IF+ T LA Sbjct: 948 LFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH- 1006 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 +D L +D ARP + + LS SQ+ +WF YR +G Sbjct: 1007 -----------IDTLDSDS-------ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNA 1048 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRA 1175 N+P A GP RHE LRT + E GVP+QI+ P ++ VR Sbjct: 1049 VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP--PAEVPVRC 1106 Query: 1176 IDQDEFDDVSTQL---RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIV 1232 + + +L R +VF E+ ++A LL P+ VL L+VHHI DH S ++ Sbjct: 1107 AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVL 1165 Query: 1233 FDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPD 1290 F DL+ AYRAR P W LP+Q+ADY+VWQ + G + DYW L GL Sbjct: 1166 FTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAG 1225 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 E + D RP +L G+ V+F + AA R L ++ G TEFML QAA+AVVLHK G Sbjct: 1226 ETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAG 1285 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 GG D+ +G+PVA R E QL+G F N+VVLR DL G+PTLR +L +R L A AHQ Sbjct: 1286 GGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQ 1345 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---TG-RGETTVVPLPVNF 1466 +LP +++VEA+NP R+LSRNPLF +++ R + +P+D TG G+TT+ L F Sbjct: 1346 DLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPTF 1401 Query: 1467 EVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 + A L++ E VI +LYE Sbjct: 1402 DAAQADLSVNFFAC-GDEYRGHVIYRTELYE 1431 Score = 126 bits (317), Expect = 2e-26 Identities = 129/465 (27%), Positives = 193/465 (41%), Gaps = 45/465 (9%) Query: 43 RLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVD 102 RLS Q R WF D + NI A L G D + A+ DVVARH ILRT Y + Sbjct: 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-E 1087 Query: 103 TEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 G P+Q+ EV R + + +E G FDL + P+R ++ Sbjct: 1088 IGGVPHQIIQPPAEVP------VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS 1141 Query: 163 TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVE 211 T ++ VL LVVHHI D S V F +L AY LP+ Sbjct: 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query: 212 VLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR-----------PLP 260 +L + A YW L G++G R R L Sbjct: 1201 LLDDGAGIVGPQRDYWIRQL---------GGLAGETGLRPDFPRPALLSGAGDAVEFRLG 1251 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A + ++ +R + FM+L AA V++ + G D + PV RS A L G+F Sbjct: 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-DLL 377 N ++LR R T + R+ LA +AHQ + D+VV NP+R + R+ + D++ Sbjct: 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV 1371 Query: 378 VRLGFNM-RKSAGGLALDG-VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSS 435 V + M + DG +R L AA LS+ D+ Y+ +L Sbjct: 1372 VHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYE 1431 Query: 436 VLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQSH 479 Q +L V +A A+ P++PL ++++ A R +L +S+ Sbjct: 1432 RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1577 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1636 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1637 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1680 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1542 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1543 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1584 Query: 922 YL 923 L Sbjct: 1585 IL 1586 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1620 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1621 GGIPLTARMVFEHPVLCELAA 1641 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 941 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1000 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1001 TALAGHIDTLDSD 1013 >tr|C1AQU3|C1AQU3_MYCBT Tax_Id=561275 (mbtE)SubName: Full=Peptide synthetase;[Mycobacterium bovis] Length = 1682 Score = 1053 bits (2724), Expect = 0.0 Identities = 617/1471 (41%), Positives = 829/1471 (56%), Gaps = 64/1471 (4%) Query: 51 MWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQV 110 MWF+Q DP LNICV+YR+ G +D RL AVN V RH ILRTTY V +G Sbjct: 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query: 111 FSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVL 170 D+ GW + DLT L + ++E LA EF PF+L+ + PLRITV+RT ADE VL Sbjct: 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query: 171 LLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAA---PSVADVGYW 227 LLV HHI WDD SW VFF +L+ AY+ + L E ++A+ + AD+ YW Sbjct: 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD----LGPEHRPSAASGPDTTEADLNYW 176 Query: 228 AETLRXXXXXXXXXGVSGA--NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAA 285 + G +G RA R LPA +RV A+ +P+MVLLAA Sbjct: 177 RAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 Query: 286 YGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRET 345 +G LV RYT + DFLV+ PV R A+GYFGNT+ +R+ +S +F + R+ Sbjct: 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 Query: 346 CLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLG 404 FAHQ + +DRVVRE NP+R R G + + R+ F R+ GG G+ + L Sbjct: 297 ASGAFAHQRINLDRVVRELNPDR--RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLR 354 Query: 405 AVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSL 463 + LPL + D V VE E+ + L L QML H+ L+D ALA P+ LS L Sbjct: 355 SNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGL 414 Query: 464 DILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHR 523 ++ + + S GE + P T+V V + TY +L+ Sbjct: 415 ALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV--VYEGQHFTYHDLNE 472 Query: 524 RANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLI 583 +NRL W I QG G ED + + + S + IV L V+K+GA Y+P+DP+YP +R+D+++ Sbjct: 473 ASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFIL 532 Query: 584 TDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVA 643 D + V+ P ++A SD P +D+DR+RPLRP + AY+IYTSG+TG PKGVA Sbjct: 533 ADCDAKLVLRTPVRELA----GYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGVA 587 Query: 644 VSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGD 703 V H +AE+ F E+ + DR LQ +S SFD S+A+IF TL GA++++P+P D Sbjct: 588 VPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTD 647 Query: 704 ISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYF 763 I Y+ L+ G+T QWR L+ VP+GGE LPGEVAD+F F Sbjct: 648 IGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 Query: 764 DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGEL 823 DA L N YGPTE V+ ++ V G G R+VPIG P N ++LD+ L PVP VIGE+ Sbjct: 708 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEI 767 Query: 824 YLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKI 883 Y+GG+ +A GY R LTA+RF+ADPFNPG R+YR+GDL RRN G++EFVGRADEQVKI Sbjct: 768 YIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKI 827 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEE-TEAGPMLAAYLVPAA-------AQVDLEEI 935 RGFRIELG+V + I P V +VV + G L Y+ PAA VDL+ I Sbjct: 828 RGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRI 887 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 RA AAA+PEYM+P A+ V+ EIP+T GK+DR ALP P + +R P+TATER + Sbjct: 888 RARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQ 947 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +F +L GR RVGA+DSFF LGGHSLLA +LVA +R FGVD+ VR IF+ T LA Sbjct: 948 LFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH- 1006 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 +D L +D ARP + + LS SQ+ +WF YR +G Sbjct: 1007 -----------IDTLDSDS-------ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNA 1048 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRA 1175 N+P A GP RHE LRT + E GVP+QI+ P ++ VR Sbjct: 1049 VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP--PAEVPVRC 1106 Query: 1176 IDQDEFDDVSTQL---RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIV 1232 + + +L R +VF E+ ++A LL P+ VL L+VHHI DH S ++ Sbjct: 1107 AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVL 1165 Query: 1233 FDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPD 1290 F DL+ AYRAR P W LP+Q+ADY+VWQ + G + DYW L GL Sbjct: 1166 FTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAG 1225 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 E + D RP +L G+ V+F + AA R L ++ G TEFML QAA+AVVLHK G Sbjct: 1226 ETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAG 1285 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 GG D+ +G+PVA R E QL+G F N+VVLR DL G+PTLR +L +R L A AHQ Sbjct: 1286 GGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQ 1345 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---TG-RGETTVVPLPVNF 1466 +LP +++VEA+NP R+LSRNPLF +++ R + +P+D TG G+TT+ L F Sbjct: 1346 DLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPTF 1401 Query: 1467 EVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 + A L++ E VI +LYE Sbjct: 1402 DAAQADLSVNFFAC-GDEYRGHVIYRTELYE 1431 Score = 126 bits (317), Expect = 2e-26 Identities = 129/465 (27%), Positives = 193/465 (41%), Gaps = 45/465 (9%) Query: 43 RLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVD 102 RLS Q R WF D + NI A L G D + A+ DVVARH ILRT Y + Sbjct: 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-E 1087 Query: 103 TEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 G P+Q+ EV R + + +E G FDL + P+R ++ Sbjct: 1088 IGGVPHQIIQPPAEVP------VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS 1141 Query: 163 TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVE 211 T ++ VL LVVHHI D S V F +L AY LP+ Sbjct: 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query: 212 VLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR-----------PLP 260 +L + A YW L G++G R R L Sbjct: 1201 LLDDGAGIVGPQRDYWIRQL---------GGLAGETGLRPDFPRPALLSGAGDAVEFRLG 1251 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A + ++ +R + FM+L AA V++ + G D + PV RS A L G+F Sbjct: 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-DLL 377 N ++LR R T + R+ LA +AHQ + D+VV NP+R + R+ + D++ Sbjct: 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV 1371 Query: 378 VRLGFNM-RKSAGGLALDG-VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSS 435 V + M + DG +R L AA LS+ D+ Y+ +L Sbjct: 1372 VHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYE 1431 Query: 436 VLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQSH 479 Q +L V +A A+ P++PL ++++ A R +L +S+ Sbjct: 1432 RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1577 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1636 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1637 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1680 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1542 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1543 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1584 Query: 922 YL 923 L Sbjct: 1585 IL 1586 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1620 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1621 GGIPLTARMVFEHPVLCELAA 1641 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 941 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1000 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1001 TALAGHIDTLDSD 1013 >tr|A5U573|A5U573_MYCTA Tax_Id=419947 (mbtE)SubName: Full=Peptide synthetase;[Mycobacterium tuberculosis] Length = 1682 Score = 1053 bits (2724), Expect = 0.0 Identities = 617/1471 (41%), Positives = 829/1471 (56%), Gaps = 64/1471 (4%) Query: 51 MWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQV 110 MWF+Q DP LNICV+YR+ G +D RL AVN V RH ILRTTY V +G Sbjct: 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query: 111 FSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVL 170 D+ GW + DLT L + ++E LA EF PF+L+ + PLRITV+RT ADE VL Sbjct: 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query: 171 LLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAA---PSVADVGYW 227 LLV HHI WDD SW VFF +L+ AY+ + L E ++A+ + AD+ YW Sbjct: 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD----LGPEHRPSAASGPDTTEADLNYW 176 Query: 228 AETLRXXXXXXXXXGVSGA--NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAA 285 + G +G RA R LPA +RV A+ +P+MVLLAA Sbjct: 177 RAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 Query: 286 YGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRET 345 +G LV RYT + DFLV+ PV R A+GYFGNT+ +R+ +S +F + R+ Sbjct: 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 Query: 346 CLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLG 404 FAHQ + +DRVVRE NP+R R G + + R+ F R+ GG G+ + L Sbjct: 297 ASGAFAHQRINLDRVVRELNPDR--RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLR 354 Query: 405 AVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSL 463 + LPL + D V VE E+ + L L QML H+ L+D ALA P+ LS L Sbjct: 355 SNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGL 414 Query: 464 DILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHR 523 ++ + + S GE + P T+V V + TY +L+ Sbjct: 415 ALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV--VYEGQHFTYHDLNE 472 Query: 524 RANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLI 583 +NRL W I QG G ED + + + S + IV L V+K+GA Y+P+DP+YP +R+D+++ Sbjct: 473 ASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFIL 532 Query: 584 TDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVA 643 D + V+ P ++A SD P +D+DR+RPLRP + AY+IYTSG+TG PKGVA Sbjct: 533 ADCDAKLVLRTPVRELA----GYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGVA 587 Query: 644 VSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGD 703 V H +AE+ F E+ + DR LQ +S SFD S+A+IF TL GA++++P+P D Sbjct: 588 VPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTD 647 Query: 704 ISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYF 763 I Y+ L+ G+T QWR L+ VP+GGE LPGEVAD+F F Sbjct: 648 IGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 Query: 764 DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGEL 823 DA L N YGPTE V+ ++ V G G R+VPIG P N ++LD+ L PVP VIGE+ Sbjct: 708 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEI 767 Query: 824 YLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKI 883 Y+GG+ +A GY R LTA+RF+ADPFNPG R+YR+GDL RRN G++EFVGRADEQVKI Sbjct: 768 YIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKI 827 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEE-TEAGPMLAAYLVPAA-------AQVDLEEI 935 RGFRIELG+V + I P V +VV + G L Y+ PAA VDL+ I Sbjct: 828 RGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRI 887 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 RA AAA+PEYM+P A+ V+ EIP+T GK+DR ALP P + +R P+TATER + Sbjct: 888 RARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQ 947 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +F +L GR RVGA+DSFF LGGHSLLA +LVA +R FGVD+ VR IF+ T LA Sbjct: 948 LFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH- 1006 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 +D L +D ARP + + LS SQ+ +WF YR +G Sbjct: 1007 -----------IDTLDSDS-------ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNA 1048 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRA 1175 N+P A GP RHE LRT + E GVP+QI+ P ++ VR Sbjct: 1049 VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP--PAEVPVRC 1106 Query: 1176 IDQDEFDDVSTQL---RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIV 1232 + + +L R +VF E+ ++A LL P+ VL L+VHHI DH S ++ Sbjct: 1107 AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVL 1165 Query: 1233 FDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPD 1290 F DL+ AYRAR P W LP+Q+ADY+VWQ + G + DYW L GL Sbjct: 1166 FTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAG 1225 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 E + D RP +L G+ V+F + AA R L ++ G TEFML QAA+AVVLHK G Sbjct: 1226 ETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAG 1285 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 GG D+ +G+PVA R E QL+G F N+VVLR DL G+PTLR +L +R L A AHQ Sbjct: 1286 GGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQ 1345 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---TG-RGETTVVPLPVNF 1466 +LP +++VEA+NP R+LSRNPLF +++ R + +P+D TG G+TT+ L F Sbjct: 1346 DLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPTF 1401 Query: 1467 EVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 + A L++ E VI +LYE Sbjct: 1402 DAAQADLSVNFFAC-GDEYRGHVIYRTELYE 1431 Score = 126 bits (317), Expect = 2e-26 Identities = 129/465 (27%), Positives = 193/465 (41%), Gaps = 45/465 (9%) Query: 43 RLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVD 102 RLS Q R WF D + NI A L G D + A+ DVVARH ILRT Y + Sbjct: 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-E 1087 Query: 103 TEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 G P+Q+ EV R + + +E G FDL + P+R ++ Sbjct: 1088 IGGVPHQIIQPPAEVP------VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS 1141 Query: 163 TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVE 211 T ++ VL LVVHHI D S V F +L AY LP+ Sbjct: 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query: 212 VLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR-----------PLP 260 +L + A YW L G++G R R L Sbjct: 1201 LLDDGAGIVGPQRDYWIRQL---------GGLAGETGLRPDFPRPALLSGAGDAVEFRLG 1251 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A + ++ +R + FM+L AA V++ + G D + PV RS A L G+F Sbjct: 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-DLL 377 N ++LR R T + R+ LA +AHQ + D+VV NP+R + R+ + D++ Sbjct: 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV 1371 Query: 378 VRLGFNM-RKSAGGLALDG-VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSS 435 V + M + DG +R L AA LS+ D+ Y+ +L Sbjct: 1372 VHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYE 1431 Query: 436 VLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQSH 479 Q +L V +A A+ P++PL ++++ A R +L +S+ Sbjct: 1432 RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1577 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1636 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1637 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1680 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1542 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1543 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1584 Query: 922 YL 923 L Sbjct: 1585 IL 1586 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1620 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1621 GGIPLTARMVFEHPVLCELAA 1641 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 941 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1000 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1001 TALAGHIDTLDSD 1013 >tr|A1KL70|A1KL70_MYCBP Tax_Id=410289 (mbtE)SubName: Full=Peptide synthetase mbtE;[Mycobacterium bovis] Length = 1682 Score = 1053 bits (2724), Expect = 0.0 Identities = 617/1471 (41%), Positives = 829/1471 (56%), Gaps = 64/1471 (4%) Query: 51 MWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQV 110 MWF+Q DP LNICV+YR+ G +D RL AVN V RH ILRTTY V +G Sbjct: 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query: 111 FSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVL 170 D+ GW + DLT L + ++E LA EF PF+L+ + PLRITV+RT ADE VL Sbjct: 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query: 171 LLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAA---PSVADVGYW 227 LLV HHI WDD SW VFF +L+ AY+ + L E ++A+ + AD+ YW Sbjct: 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD----LGPEHRPSAASGPDTTEADLNYW 176 Query: 228 AETLRXXXXXXXXXGVSGA--NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAA 285 + G +G RA R LPA +RV A+ +P+MVLLAA Sbjct: 177 RAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 Query: 286 YGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRET 345 +G LV RYT + DFLV+ PV R A+GYFGNT+ +R+ +S +F + R+ Sbjct: 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 Query: 346 CLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLG 404 FAHQ + +DRVVRE NP+R R G + + R+ F R+ GG G+ + L Sbjct: 297 ASGAFAHQRINLDRVVRELNPDR--RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLR 354 Query: 405 AVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSL 463 + LPL + D V VE E+ + L L QML H+ L+D ALA P+ LS L Sbjct: 355 SNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGL 414 Query: 464 DILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHR 523 ++ + + S GE + P T+V V + TY +L+ Sbjct: 415 ALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV--VYEGQHFTYHDLNE 472 Query: 524 RANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLI 583 +NRL W I QG G ED + + + S + IV L V+K+GA Y+P+DP+YP +R+D+++ Sbjct: 473 ASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFIL 532 Query: 584 TDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVA 643 D + V+ P ++A SD P +D+DR+RPLRP + AY+IYTSG+TG PKGVA Sbjct: 533 ADCDAKLVLRTPVRELA----GYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGVA 587 Query: 644 VSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGD 703 V H +AE+ F E+ + DR LQ +S SFD S+A+IF TL GA++++P+P D Sbjct: 588 VPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTD 647 Query: 704 ISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYF 763 I Y+ L+ G+T QWR L+ VP+GGE LPGEVAD+F F Sbjct: 648 IGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 Query: 764 DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGEL 823 DA L N YGPTE V+ ++ V G G R+VPIG P N ++LD+ L PVP VIGE+ Sbjct: 708 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEI 767 Query: 824 YLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKI 883 Y+GG+ +A GY R LTA+RF+ADPFNPG R+YR+GDL RRN G++EFVGRADEQVKI Sbjct: 768 YIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKI 827 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEE-TEAGPMLAAYLVPAA-------AQVDLEEI 935 RGFRIELG+V + I P V +VV + G L Y+ PAA VDL+ I Sbjct: 828 RGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRI 887 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 RA AAA+PEYM+P A+ V+ EIP+T GK+DR ALP P + +R P+TATER + Sbjct: 888 RARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQ 947 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +F +L GR RVGA+DSFF LGGHSLLA +LVA +R FGVD+ VR IF+ T LA Sbjct: 948 LFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH- 1006 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 +D L +D ARP + + LS SQ+ +WF YR +G Sbjct: 1007 -----------IDTLDSDS-------ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNA 1048 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRA 1175 N+P A GP RHE LRT + E GVP+QI+ P ++ VR Sbjct: 1049 VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP--PAEVPVRC 1106 Query: 1176 IDQDEFDDVSTQL---RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIV 1232 + + +L R +VF E+ ++A LL P+ VL L+VHHI DH S ++ Sbjct: 1107 AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVL 1165 Query: 1233 FDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPD 1290 F DL+ AYRAR P W LP+Q+ADY+VWQ + G + DYW L GL Sbjct: 1166 FTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAG 1225 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 E + D RP +L G+ V+F + AA R L ++ G TEFML QAA+AVVLHK G Sbjct: 1226 ETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAG 1285 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 GG D+ +G+PVA R E QL+G F N+VVLR DL G+PTLR +L +R L A AHQ Sbjct: 1286 GGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQ 1345 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---TG-RGETTVVPLPVNF 1466 +LP +++VEA+NP R+LSRNPLF +++ R + +P+D TG G+TT+ L F Sbjct: 1346 DLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPTF 1401 Query: 1467 EVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 + A L++ E VI +LYE Sbjct: 1402 DAAQADLSVNFFAC-GDEYRGHVIYRTELYE 1431 Score = 126 bits (317), Expect = 2e-26 Identities = 129/465 (27%), Positives = 193/465 (41%), Gaps = 45/465 (9%) Query: 43 RLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVD 102 RLS Q R WF D + NI A L G D + A+ DVVARH ILRT Y + Sbjct: 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-E 1087 Query: 103 TEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 G P+Q+ EV R + + +E G FDL + P+R ++ Sbjct: 1088 IGGVPHQIIQPPAEVP------VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS 1141 Query: 163 TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVE 211 T ++ VL LVVHHI D S V F +L AY LP+ Sbjct: 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query: 212 VLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR-----------PLP 260 +L + A YW L G++G R R L Sbjct: 1201 LLDDGAGIVGPQRDYWIRQL---------GGLAGETGLRPDFPRPALLSGAGDAVEFRLG 1251 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A + ++ +R + FM+L AA V++ + G D + PV RS A L G+F Sbjct: 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-DLL 377 N ++LR R T + R+ LA +AHQ + D+VV NP+R + R+ + D++ Sbjct: 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV 1371 Query: 378 VRLGFNM-RKSAGGLALDG-VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSS 435 V + M + DG +R L AA LS+ D+ Y+ +L Sbjct: 1372 VHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYE 1431 Query: 436 VLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQSH 479 Q +L V +A A+ P++PL ++++ A R +L +S+ Sbjct: 1432 RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Score = 97.1 bits (240), Expect = 2e-17 Identities = 54/108 (50%), Positives = 75/108 (69%), Gaps = 4/108 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct: 1577 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1636 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 ELAAAVDA +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct: 1637 CELAAAVDA---KPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1680 Score = 64.3 bits (155), Expect = 1e-07 Identities = 47/122 (38%), Positives = 63/122 (51%), Gaps = 24/122 (19%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct: 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE-- 1542 Query: 864 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE--ETEAGPMLAA 921 V +AD Q+++ L E+E + P + V AE +TE LAA Sbjct: 1543 --------RGVWKADGQLEL------LAEIERL----PTAQAAPVPAEPADTETERALAA 1584 Query: 922 YL 923 L Sbjct: 1585 IL 1586 Score = 51.6 bits (122), Expect = 0.001 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 2/81 (2%) Query: 974 PTPIATRRYREP-ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 PT A EP +T TER + +I A + VG D FF LGG S+LA ++ A+ R + Sbjct: 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1620 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ LT R +F+ P LAA Sbjct: 1621 GGIPLTARMVFEHPVLCELAA 1641 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TERRL + ELL + D+++F LGG S++A K +A A G+ +FE T+ Sbjct: 941 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1000 Query: 1618 AELAAAVDAANGE 1630 LA +D + + Sbjct: 1001 TALAGHIDTLDSD 1013 >tr|Q1B6B1|Q1B6B1_MYCSS Tax_Id=164756 SubName: Full=Amino acid adenylation;[Mycobacterium sp.] Length = 1745 Score = 1032 bits (2669), Expect = 0.0 Identities = 613/1494 (41%), Positives = 837/1494 (56%), Gaps = 75/1494 (5%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 + E GL+++ G P R LS+GQ+RMWF+Q DP LN+CV+YR+ G VD Sbjct: 23 LTERGLSSQHPR---GTEPSTR-ELSEGQQRMWFVQAADPSGALLNVCVSYRIRGAVDLA 78 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQ---I 136 L A++ V RH +LRTTY D G P D+ W DLT L + Q + Sbjct: 79 ALRGALDAVARRHPVLRTTYAADDTGAPRPTVHADLRPAWAEHDLTGLANQSEQAQRLRL 138 Query: 137 ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN 196 E LA EF PFDL+ + PLRIT++ T +DE V+LLV HHI WDD SWEVFFG+L+ AY Sbjct: 139 EVLAQREFAAPFDLSTDAPLRITMVHTGSDEYVMLLVAHHIAWDDGSWEVFFGDLTRAY- 197 Query: 197 DLPINDPAAQFLSVEVLQNSAA---PSVADVGYWAETLRXXXXXXXXXGVSG-ANPCR-R 251 A + L E+ ++ A + D+ YW + G +G A P R Sbjct: 198 -------AGEDLGEELEPHAPAVPRDAADDLAYWRRVMADPPEPLELPGPTGSAVPTGWR 250 Query: 252 AQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA 311 + R L A RV D AR+ +P+ VLLA +G L+ RYT A DFLV+ PV R Sbjct: 251 SARTGVALDADTARRVVDLARETGCTPYAVLLAVFGTLIHRYTHADDFLVATPVLNRGTG 310 Query: 312 AAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGR 371 +GY+GNT+ +R+ + +F + + R+T L FAHQ V +D+VVRE NP+R R Sbjct: 311 TEDRIGYYGNTVAMRLRPTTSMSFRDMLIQTRDTALGAFAHQGVNVDQVVRELNPDR--R 368 Query: 372 DGMDLLVRLGFNMR-KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVS----VE 426 G + + R+ F R G A GV + L + LPL + + D + VE Sbjct: 369 HGTERMTRVSFGFRGPDRFGFAPAGVHCERADLRSHLTQLPLGVMVEFDAEPSGGGAVVE 428 Query: 427 FEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM 485 E+ ++ L Q+L H++ L+ AL P+ L+ L ++ A + + + G+ + Sbjct: 429 VEHLVEIIEPALAQQLLDHFVVLLGSALDRPDTTLARLALMSAADAAWLHDVARGDHFDT 488 Query: 486 PATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGL 545 P T+ + TY E++ +ANR+A W IGQ G ED + + Sbjct: 489 PPRTL--PDLIAAQVATTPDEIAVAYEGRHYTYREINEQANRVAHWLIGQSIGAEDRVAV 546 Query: 546 RMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAA 605 + S E IV L V KAGA Y+P+DP YP++R+ +++ D + V+ P + A Sbjct: 547 LLDKSPELIVTALGVAKAGAVYVPVDPTYPEDRLAFILGDCDAKLVLREPVSGLDGTPAH 606 Query: 606 DNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAE 665 D +D +DRLRPL P + AY+IYTSG+TG PKGV VSH +AE+ F A++ + A+ Sbjct: 607 DPTD-----ADRLRPLLPENTAYLIYTSGTTGLPKGVPVSHRPVAEYFVWFKADYQVDAK 661 Query: 666 DRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXX 725 DR LQ +S SFD S+A+IF L GA++++ +P DI Y+ +L+ +T Sbjct: 662 DRLLQVASPSFDVSIAEIFGMLACGARIVIHRPGGLNDIGYLTELLRDERITAMHFVPSL 721 Query: 726 XXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVV 785 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V Sbjct: 722 LGLFLSLPGVNQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRYKV 781 Query: 786 TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 G G R+VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY RP LTA+RF Sbjct: 782 EGKQGTRIVPIGRPKINTQMHLLDDALQPVPVGVIGEIYIGGTHVAHGYHRRPGLTAERF 841 Query: 846 IADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRH 905 +ADPF PG RLYR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I+ P+V Sbjct: 842 VADPFTPGGRLYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAISVDPSVGQ 901 Query: 906 CLV-VAEETEAGPMLAAYLVPAAAQ----VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 +V V+E G L YL P + + V ++ IRA AAA+PEYMVP A+ V+ E+P+ Sbjct: 902 AVVMVSELPNLGKSLVGYLTPVSGEDRDSVAVDRIRARVAAALPEYMVPAAYVVLDEVPI 961 Query: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQ-RVGAEDSFFGLGGHS 1019 T GK+DR ALPAP +T +REP T TER + +F +L GR +GA+DSFF LGGHS Sbjct: 962 TTHGKIDRAALPAPELTSTADFREPGTDTEREMARLFGELLGRSANIGADDSFFDLGGHS 1021 Query: 1020 LLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDP 1079 LLA +LVA +R GVD+ V+ +F+ T A LA V+ R A P Sbjct: 1022 LLATKLVAAVRTSCGVDIGVQEVFELATVAQLAGH-VDALR----------AGGGGP--- 1067 Query: 1080 KRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 ARP + PLS SQL +WF YR++G N+P A R GP Sbjct: 1068 --ARPRLMPLHLDGPAPLSSSQLRSWFAYRVDGPSVVNNIPFAARLRGPCDVDALVTAIG 1125 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPE 1196 RHE LRT + E +GVP+Q+V P V VR D + + +L R HVF E Sbjct: 1126 DVVNRHEILRTVYREIDGVPHQVVLPPEPV--TVRRAHGDGEEWLRAELDRERAHVFDLE 1183 Query: 1197 SG-PLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILP 1255 P+ A L V PD VL +++HHI DH S ++F DL+ AYRAR AP W LP Sbjct: 1184 QDRPIRPAVLRV--PDGVVLSVVMHHIAGDHWSATVLFADLLTAYRARAAGEAPAWAPLP 1241 Query: 1256 IQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQF 1313 +Q+AD+ WQ + G + DYW LAGLP+E + D ARP V R E V+F Sbjct: 1242 LQYADFGAWQTALLADDAGIAGPQRDYWTRQLAGLPEETGLRPDFARPPVPSGRAEAVEF 1301 Query: 1314 SVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLV 1373 + A R LT L G TEFML QAA+AVVLHK GGG D+ LG+PVA R EP QLV Sbjct: 1302 HIDGATRDKLTALCRELGVTEFMLLQAAVAVVLHKAGGGPDVPLGTPVAGRSEPELDQLV 1361 Query: 1374 GLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLF 1433 G F N++VLR DL G+PTLR + +R+ L+A AHQ+LP +++V+A++P R L+RNPLF Sbjct: 1362 GFFINILVLRNDLRGNPTLREVCRRAREMALEAYAHQDLPFDQVVDAVSPVRTLARNPLF 1421 Query: 1434 QNMLNFRGEDWALVPRDLT----GRGETTVVPLPVNFEVALLFLAIGMSVTPSG 1483 +++ R + +P D G+TTV L F+ A L++ + G Sbjct: 1422 SVVVHVREQ----LPEDRVIAHGPDGDTTVTVLEPTFDAAHADLSLNFFASERG 1471 Score = 86.7 bits (213), Expect = 3e-14 Identities = 48/106 (45%), Positives = 68/106 (64%), Gaps = 4/106 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 +TER L +L ++L++ R +++F+LGGDSI+A++ +A+A GL MVFE T+ Sbjct: 1636 DTERALATLLADVLDVEVTRRHDDFFSLGGDSILAVQLAARARDAGLRLTARMVFEQPTL 1695 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 +LAAAVDAA P P + PMSASGL+ D LA L+ASW Sbjct: 1696 QDLAAAVDAAAETP----GPAGDTAHAPMSASGLSADELAALTASW 1737 Score = 66.2 bits (160), Expect = 4e-08 Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 34/188 (18%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 +VLDE L PVP V+G++Y G LA + G LTA RF+A P+ + G RL+RTGD Sbjct: 1542 FVLDETLRPVPVGVVGDVYTAGGPLAAAHWGEAALTATRFVAHPYGADAGGRLHRTGDQA 1601 Query: 864 RRNHCGELEFVG----RADEQVKIRGFRIE-------------LGEVESVITTH------ 900 R + G LE VG A+ V+ G E L +V V T Sbjct: 1602 RWSADGVLELVGAEGLAAEPAVRAAGHTAEPPATDTERALATLLADVLDVEVTRRHDDFF 1661 Query: 901 ----PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIP 956 ++ + A +AG L A +V Q L+++ A AA PG Sbjct: 1662 SLGGDSILAVQLAARARDAGLRLTARMV--FEQPTLQDLAAAVDAAAE---TPGPAGDTA 1716 Query: 957 EIPMTVSG 964 PM+ SG Sbjct: 1717 HAPMSASG 1724 Score = 50.4 bits (119), Expect = 0.002 Identities = 28/69 (40%), Positives = 40/69 (57%), Gaps = 1/69 (1%) Query: 985 PETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFD 1044 P T TER + ++ A + + D FF LGG S+LA +L A+ R + G+ LT R +F+ Sbjct: 1633 PATDTERALATLLADVLDVEVTRRHDDFFSLGGDSILAVQLAARAR-DAGLRLTARMVFE 1691 Query: 1045 APTPAGLAA 1053 PT LAA Sbjct: 1692 QPTLQDLAA 1700 Score = 43.5 bits (101), Expect = 0.26 Identities = 35/108 (32%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Query: 1558 ETERRLTAMLEELL-EITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHM 1615 +TER + + ELL I D+++F LGG S++A K +A + G+ VFE Sbjct: 989 DTEREMARLFGELLGRSANIGADDSFFDLGGHSLLATKLVAAVRTSCGVDIGVQEVFELA 1048 Query: 1616 TIAELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 T+A+LA VDA P P+ G AP + ++L SW Sbjct: 1049 TVAQLAGHVDALR----AGGGGPARPRLMPLHLDGPAPLSSSQL-RSW 1091 >tr|A1UIR5|A1UIR5_MYCSK Tax_Id=189918 SubName: Full=Amino acid adenylation domain;[Mycobacterium sp.] Length = 1745 Score = 1032 bits (2669), Expect = 0.0 Identities = 613/1494 (41%), Positives = 837/1494 (56%), Gaps = 75/1494 (5%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 + E GL+++ G P R LS+GQ+RMWF+Q DP LN+CV+YR+ G VD Sbjct: 23 LTERGLSSQHPR---GTEPSTR-ELSEGQQRMWFVQAADPSGALLNVCVSYRIRGAVDLA 78 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQ---I 136 L A++ V RH +LRTTY D G P D+ W DLT L + Q + Sbjct: 79 ALRGALDAVARRHPVLRTTYAADDTGAPRPTVHADLRPAWAEHDLTGLANQSEQAQRLRL 138 Query: 137 ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN 196 E LA EF PFDL+ + PLRIT++ T +DE V+LLV HHI WDD SWEVFFG+L+ AY Sbjct: 139 EVLAQREFAAPFDLSTDAPLRITMVHTGSDEYVMLLVAHHIAWDDGSWEVFFGDLTRAY- 197 Query: 197 DLPINDPAAQFLSVEVLQNSAA---PSVADVGYWAETLRXXXXXXXXXGVSG-ANPCR-R 251 A + L E+ ++ A + D+ YW + G +G A P R Sbjct: 198 -------AGEDLGEELEPHAPAVPRDAADDLAYWRRVMADPPEPLELPGPTGSAVPTGWR 250 Query: 252 AQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA 311 + R L A RV D AR+ +P+ VLLA +G L+ RYT A DFLV+ PV R Sbjct: 251 SARTGVALDADTARRVVDLARETGCTPYAVLLAVFGTLIHRYTHADDFLVATPVLNRGTG 310 Query: 312 AAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGR 371 +GY+GNT+ +R+ + +F + + R+T L FAHQ V +D+VVRE NP+R R Sbjct: 311 TEDRIGYYGNTVAMRLRPTTSMSFRDMLIQTRDTALGAFAHQGVNVDQVVRELNPDR--R 368 Query: 372 DGMDLLVRLGFNMR-KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVS----VE 426 G + + R+ F R G A GV + L + LPL + + D + VE Sbjct: 369 HGTERMTRVSFGFRGPDRFGFAPAGVHCERADLRSHLTQLPLGVMVEFDAEPSGGGAVVE 428 Query: 427 FEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM 485 E+ ++ L Q+L H++ L+ AL P+ L+ L ++ A + + + G+ + Sbjct: 429 VEHLVEIIEPALAQQLLDHFVVLLGSALDRPDTTLARLALMSAADAAWLHDVARGDHFDT 488 Query: 486 PATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGL 545 P T+ + TY E++ +ANR+A W IGQ G ED + + Sbjct: 489 PPRTL--PDLIAAQVATTPDEIAVAYEGRHYTYREINEQANRVAHWLIGQSIGAEDRVAV 546 Query: 546 RMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAA 605 + S E IV L V KAGA Y+P+DP YP++R+ +++ D + V+ P + A Sbjct: 547 LLDKSPELIVTALGVAKAGAVYVPVDPTYPEDRLAFILGDCDAKLVLREPVSGLDGTPAH 606 Query: 606 DNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAE 665 D +D +DRLRPL P + AY+IYTSG+TG PKGV VSH +AE+ F A++ + A+ Sbjct: 607 DPTD-----ADRLRPLLPENTAYLIYTSGTTGLPKGVPVSHRPVAEYFVWFKADYQVDAK 661 Query: 666 DRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXX 725 DR LQ +S SFD S+A+IF L GA++++ +P DI Y+ +L+ +T Sbjct: 662 DRLLQVASPSFDVSIAEIFGMLACGARIVIHRPGGLNDIGYLTELLRDERITAMHFVPSL 721 Query: 726 XXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVV 785 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V Sbjct: 722 LGLFLSLPGVNQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRYKV 781 Query: 786 TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 G G R+VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY RP LTA+RF Sbjct: 782 EGKQGTRIVPIGRPKINTQMHLLDDALQPVPVGVIGEIYIGGTHVAHGYHRRPGLTAERF 841 Query: 846 IADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRH 905 +ADPF PG RLYR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I+ P+V Sbjct: 842 VADPFTPGGRLYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAISVDPSVGQ 901 Query: 906 CLV-VAEETEAGPMLAAYLVPAAAQ----VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 +V V+E G L YL P + + V ++ IRA AAA+PEYMVP A+ V+ E+P+ Sbjct: 902 AVVMVSELPNLGKSLVGYLTPVSGEDRDSVAVDRIRARVAAALPEYMVPAAYVVLDEVPI 961 Query: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQ-RVGAEDSFFGLGGHS 1019 T GK+DR ALPAP +T +REP T TER + +F +L GR +GA+DSFF LGGHS Sbjct: 962 TTHGKIDRAALPAPELTSTADFREPGTDTEREMARLFGELLGRSANIGADDSFFDLGGHS 1021 Query: 1020 LLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDP 1079 LLA +LVA +R GVD+ V+ +F+ T A LA V+ R A P Sbjct: 1022 LLATKLVAAVRTSCGVDIGVQEVFELATVAQLAGH-VDALR----------AGGGGP--- 1067 Query: 1080 KRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 ARP + PLS SQL +WF YR++G N+P A R GP Sbjct: 1068 --ARPRLMPLHLDGPAPLSSSQLRSWFAYRVDGPSVVNNIPFAARLRGPCDVDALVTAIG 1125 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPE 1196 RHE LRT + E +GVP+Q+V P V VR D + + +L R HVF E Sbjct: 1126 DVVNRHEILRTVYREIDGVPHQVVLPPEPV--TVRRAHGDGEEWLRAELDRERAHVFDLE 1183 Query: 1197 SG-PLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILP 1255 P+ A L V PD VL +++HHI DH S ++F DL+ AYRAR AP W LP Sbjct: 1184 QDRPIRPAVLRV--PDGVVLSVVMHHIAGDHWSATVLFADLLTAYRARAAGEAPAWAPLP 1241 Query: 1256 IQFADYAVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQF 1313 +Q+AD+ WQ + G + DYW LAGLP+E + D ARP V R E V+F Sbjct: 1242 LQYADFGAWQTALLADDAGIAGPQRDYWTRQLAGLPEETGLRPDFARPPVPSGRAEAVEF 1301 Query: 1314 SVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLV 1373 + A R LT L G TEFML QAA+AVVLHK GGG D+ LG+PVA R EP QLV Sbjct: 1302 HIDGATRDKLTALCRELGVTEFMLLQAAVAVVLHKAGGGPDVPLGTPVAGRSEPELDQLV 1361 Query: 1374 GLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLF 1433 G F N++VLR DL G+PTLR + +R+ L+A AHQ+LP +++V+A++P R L+RNPLF Sbjct: 1362 GFFINILVLRNDLRGNPTLREVCRRAREMALEAYAHQDLPFDQVVDAVSPVRTLARNPLF 1421 Query: 1434 QNMLNFRGEDWALVPRDLT----GRGETTVVPLPVNFEVALLFLAIGMSVTPSG 1483 +++ R + +P D G+TTV L F+ A L++ + G Sbjct: 1422 SVVVHVREQ----LPEDRVIAHGPDGDTTVTVLEPTFDAAHADLSLNFFASERG 1471 Score = 86.7 bits (213), Expect = 3e-14 Identities = 48/106 (45%), Positives = 68/106 (64%), Gaps = 4/106 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 +TER L +L ++L++ R +++F+LGGDSI+A++ +A+A GL MVFE T+ Sbjct: 1636 DTERALATLLADVLDVEVTRRHDDFFSLGGDSILAVQLAARARDAGLRLTARMVFEQPTL 1695 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 +LAAAVDAA P P + PMSASGL+ D LA L+ASW Sbjct: 1696 QDLAAAVDAAAETP----GPAGDTAHAPMSASGLSADELAALTASW 1737 Score = 66.2 bits (160), Expect = 4e-08 Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 34/188 (18%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 +VLDE L PVP V+G++Y G LA + G LTA RF+A P+ + G RL+RTGD Sbjct: 1542 FVLDETLRPVPVGVVGDVYTAGGPLAAAHWGEAALTATRFVAHPYGADAGGRLHRTGDQA 1601 Query: 864 RRNHCGELEFVG----RADEQVKIRGFRIE-------------LGEVESVITTH------ 900 R + G LE VG A+ V+ G E L +V V T Sbjct: 1602 RWSADGVLELVGAEGLAAEPAVRAAGHTAEPPATDTERALATLLADVLDVEVTRRHDDFF 1661 Query: 901 ----PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIP 956 ++ + A +AG L A +V Q L+++ A AA PG Sbjct: 1662 SLGGDSILAVQLAARARDAGLRLTARMV--FEQPTLQDLAAAVDAAAE---TPGPAGDTA 1716 Query: 957 EIPMTVSG 964 PM+ SG Sbjct: 1717 HAPMSASG 1724 Score = 50.4 bits (119), Expect = 0.002 Identities = 28/69 (40%), Positives = 40/69 (57%), Gaps = 1/69 (1%) Query: 985 PETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFD 1044 P T TER + ++ A + + D FF LGG S+LA +L A+ R + G+ LT R +F+ Sbjct: 1633 PATDTERALATLLADVLDVEVTRRHDDFFSLGGDSILAVQLAARAR-DAGLRLTARMVFE 1691 Query: 1045 APTPAGLAA 1053 PT LAA Sbjct: 1692 QPTLQDLAA 1700 Score = 43.5 bits (101), Expect = 0.26 Identities = 35/108 (32%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Query: 1558 ETERRLTAMLEELL-EITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHM 1615 +TER + + ELL I D+++F LGG S++A K +A + G+ VFE Sbjct: 989 DTEREMARLFGELLGRSANIGADDSFFDLGGHSLLATKLVAAVRTSCGVDIGVQEVFELA 1048 Query: 1616 TIAELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 T+A+LA VDA P P+ G AP + ++L SW Sbjct: 1049 TVAQLAGHVDALR----AGGGGPARPRLMPLHLDGPAPLSSSQL-RSW 1091 >tr|A3Q278|A3Q278_MYCSJ Tax_Id=164757 SubName: Full=Amino acid adenylation domain;[Mycobacterium sp.] Length = 1745 Score = 1030 bits (2662), Expect = 0.0 Identities = 611/1491 (40%), Positives = 834/1491 (55%), Gaps = 69/1491 (4%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 + E GL+++ G P R LS+GQ+RMWF+Q DP LN+CV+YR+ G VD Sbjct: 23 LTERGLSSQHPR---GTEPSTR-ELSEGQQRMWFVQAADPSGALLNVCVSYRIRGAVDLA 78 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQ---I 136 L A++ V RH +LRTTY D G P D+ W DLT L + Q + Sbjct: 79 ALRGALDAVARRHPVLRTTYAADDTGAPRPTVHADLRPAWAEHDLTGLANQSEQAQRLRL 138 Query: 137 ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN 196 E LA EF PFDL+ + PLRIT++ T +DE V+LLV HHI WDD SWEVFFG+L+ AY Sbjct: 139 EVLAQREFAAPFDLSTDAPLRITMVHTGSDEYVMLLVAHHIAWDDGSWEVFFGDLTRAYA 198 Query: 197 DLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSG-ANPCR-RAQR 254 + + V + AA D+ YW + G +G A P R+ R Sbjct: 199 GEDLGEELEPH--VPAVPRDAAD---DLAYWRRVMADPPEPLELPGPTGSAVPTGWRSAR 253 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 L A RV D AR+ +P+ VLLA +G L+ RYT A DFLV+ PV R Sbjct: 254 TGVALDADTARRVVDLARETGCTPYAVLLAVFGTLIHRYTHADDFLVATPVLNRGTGTED 313 Query: 315 ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 +GY+GNT+ +R+ + +F + + R+T L FAHQ V +D+VVRE NP+R R G Sbjct: 314 RIGYYGNTVAMRLRPTTSMSFRDMLIQTRDTALGAFAHQGVNVDQVVRELNPDR--RHGT 371 Query: 375 DLLVRLGFNMR-KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVS----VEFEY 429 + + R+ F R G A GV + L + LPL + + D + VE E+ Sbjct: 372 ERMTRVSFGFRGPDRFGFAPAGVHCERADLRSHLTQLPLGVMVEFDAEPSGGGAVVEVEH 431 Query: 430 QQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPAT 488 ++ L Q+L H++ L+ AL P+ L+ L ++ A + + + G+ + P Sbjct: 432 LVEIIEPALAQQLLDHFVVLLGSALDRPDTTLARLALMSAADAAWLHDVARGDHFDTPPR 491 Query: 489 TMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMA 548 T+ + TY E++ +ANR+A W IGQG G ED + + + Sbjct: 492 TL--PDLIAAQAATTPDEIAVAYEGRHYTYREINEQANRVAHWLIGQGIGAEDRVAVLLD 549 Query: 549 NSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNS 608 S E IV L V KAGA Y+P+DP YP++R+ +++ D + V+ P + A D + Sbjct: 550 KSPELIVTALGVAKAGAVYVPVDPTYPEDRLAFILGDCDAKLVLREPVSGLDGTPAHDPT 609 Query: 609 DLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRW 668 D +DR+RPL P + AY+IYTSG+TG PKGV VSH +AE+ F A++ + A+DR Sbjct: 610 D-----ADRVRPLLPDNTAYLIYTSGTTGLPKGVPVSHRPVAEYFVWFKADYQVDAKDRL 664 Query: 669 LQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXX 728 LQ +S SFD S+A+IF L GA++++ +P DI Y+ +L+ +T Sbjct: 665 LQVASPSFDVSIAEIFGMLACGARIVIHRPGGLNDIGYLTELLRDERITAMHFVPSLLGL 724 Query: 729 XXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGS 788 QWR L+ VP+GGE LPGEVAD+F FDA L N YGPTE V+ ++ V G Sbjct: 725 FLSLPGVNQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRYKVEGK 784 Query: 789 HGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIAD 848 G R+VPIG P N ++LD+ L PVP VIGE+Y+GG+ +A GY RP LTA+RF+AD Sbjct: 785 QGTRIVPIGRPKINTQMHLLDDALQPVPVGVIGEIYIGGTHVAHGYHRRPGLTAERFVAD 844 Query: 849 PFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLV 908 PF PG RLYR+GDL RRN G++EFVGRADEQVKIRGFRIELG+V + I+ P+V +V Sbjct: 845 PFTPGGRLYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAISVDPSVGQAVV 904 Query: 909 -VAEETEAGPMLAAYLVPAAAQ----VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVS 963 V+E G L YL P + + V ++ IRA AAA+PEYMVP A+ V+ E+P+T Sbjct: 905 MVSELPNLGKSLVGYLTPVSGEDRDSVAVDRIRARVAAALPEYMVPAAYVVLDEVPITTH 964 Query: 964 GKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQ-RVGAEDSFFGLGGHSLLA 1022 GK+DR ALPAP +T +REP T TER + +F +L GR +GA+DSFF LGGHSLLA Sbjct: 965 GKIDRAALPAPELTSTVDFREPGTDTEREMARLFGELLGRSANIGADDSFFDLGGHSLLA 1024 Query: 1023 ARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRA 1082 +LVA +R GVD+ V+ +F+ T A LA V+ R A P A Sbjct: 1025 TKLVAAVRTSCGVDIGVQEVFELATVAQLAGH-VDALR----------AGGGGP-----A 1068 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 RP + PLS SQL +WF YR++G N+P A R GP Sbjct: 1069 RPRLMPLHLDGPAPLSSSQLRSWFAYRVDGPSVVNNIPFAARLRGPCDVDALVTAIGDVV 1128 Query: 1143 XRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTPESG- 1198 RHE LRT + E +GVP+Q+V P V VR D + + +L R HVF E Sbjct: 1129 NRHEILRTVYREIDGVPHQVVLPPEPV--TVRRAHGDGEEWLRAELDRERAHVFDLEQDR 1186 Query: 1199 PLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQF 1258 P+ A L V PD VL +++HHI DH S ++F DL+ AYRAR AP W LP+Q+ Sbjct: 1187 PIRPAVLRV--PDGVVLSVVMHHIAGDHWSATVLFADLLTAYRARAAGEAPAWAPLPLQY 1244 Query: 1259 ADYAVWQRNTFESNWG--QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVP 1316 AD+ WQ + G + DYW LAGLP+E + D ARP V R V+F + Sbjct: 1245 ADFGAWQSALLADDAGIAGPQRDYWTRQLAGLPEETGLRPDFARPPVPSGRAGAVEFHID 1304 Query: 1317 AARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLF 1376 A R LT L G TEFML QAA+AVVLHK GGG D+ LG+PVA R EP QLVG F Sbjct: 1305 GATRDKLTALCRELGVTEFMLLQAAVAVVLHKAGGGPDVPLGTPVAGRSEPELDQLVGFF 1364 Query: 1377 ANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNM 1436 N++VLR DL G+PTLR + +R+ L+A AHQ+LP +++V+A++P R L+RNPLF + Sbjct: 1365 INILVLRNDLRGNPTLREVCRRAREMALEAYAHQDLPFDQVVDAVSPVRTLARNPLFSVV 1424 Query: 1437 LNFRGEDWALVPRDLT----GRGETTVVPLPVNFEVALLFLAIGMSVTPSG 1483 ++ R + +P D G+TTV L F+ A L++ + G Sbjct: 1425 VHVREQ----LPEDRVIAHGPDGDTTVTVLEPTFDAAHADLSLNFFASERG 1471 Score = 84.0 bits (206), Expect = 2e-13 Identities = 47/106 (44%), Positives = 68/106 (64%), Gaps = 4/106 (3%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 +TER L +L ++L++ R +++F+LGGDSI+A++ +A+A GL MVFE T+ Sbjct: 1636 DTERALATLLADVLDVEVTRRHDDFFSLGGDSILAVQLAARARDAGLRLTARMVFEQPTL 1695 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 +LAAAVDAA + P + PMSASGL+ D LA L+ASW Sbjct: 1696 YDLAAAVDAA----ADVSGPAGDTAHAPMSASGLSADELAALTASW 1737 Score = 65.5 bits (158), Expect = 6e-08 Identities = 35/72 (48%), Positives = 45/72 (62%), Gaps = 2/72 (2%) Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 +VLDE L PVP V+G++Y G LA + G LTA RF+A P+ + G RL+RTGD Sbjct: 1542 FVLDETLRPVPVGVVGDVYTAGGPLAAAHWGEAALTATRFVAHPYGADAGGRLHRTGDQA 1601 Query: 864 RRNHCGELEFVG 875 R + G LE VG Sbjct: 1602 RWSADGVLELVG 1613 Score = 50.1 bits (118), Expect = 0.003 Identities = 28/69 (40%), Positives = 40/69 (57%), Gaps = 1/69 (1%) Query: 985 PETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFD 1044 P T TER + ++ A + + D FF LGG S+LA +L A+ R + G+ LT R +F+ Sbjct: 1633 PATDTERALATLLADVLDVEVTRRHDDFFSLGGDSILAVQLAARAR-DAGLRLTARMVFE 1691 Query: 1045 APTPAGLAA 1053 PT LAA Sbjct: 1692 QPTLYDLAA 1700 Score = 43.5 bits (101), Expect = 0.26 Identities = 35/108 (32%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Query: 1558 ETERRLTAMLEELL-EITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHM 1615 +TER + + ELL I D+++F LGG S++A K +A + G+ VFE Sbjct: 989 DTEREMARLFGELLGRSANIGADDSFFDLGGHSLLATKLVAAVRTSCGVDIGVQEVFELA 1048 Query: 1616 TIAELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 T+A+LA VDA P P+ G AP + ++L SW Sbjct: 1049 TVAQLAGHVDALR----AGGGGPARPRLMPLHLDGPAPLSSSQL-RSW 1091 >tr|C2AVD0|C2AVD0_TSUPA Tax_Id=521096 SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein;[Tsukamurella paurometabola DSM 20162] Length = 1653 Score = 923 bits (2386), Expect = 0.0 Identities = 634/1675 (37%), Positives = 863/1675 (51%), Gaps = 77/1675 (4%) Query: 25 LAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTA 84 L A + P + L+ +RRMWF Q DP LNI AYRL G +D DRL A Sbjct: 17 LRAAGLTTTPSSVAADPAALTAPERRMWFGQRRDPSGTELNIPFAYRLTGELDADRLLGA 76 Query: 85 VNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEF 144 ++ VV RH LRT + D G V + +VGW+R DLT L E ER+I LA + Sbjct: 77 LHAVVERHPALRTVFDEDGAGPRRTVRA--AQVGWQRTDLTDLTEGERERRIRVLARRDA 134 Query: 145 GRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY--NDLPIND 202 PFDL+ + LR +IRT A E VL LVVHHI +DD S+ + +L+AAY LP Sbjct: 135 DAPFDLSRDPLLRAHLIRTAAREHVLALVVHHIAFDDASFALLLTDLAAAYAGRSLP--- 191 Query: 203 PAAQFLSVEVLQNSAAPSVAD---VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPL 259 PAA +V AP+ AD V AE LR G +G + + L Sbjct: 192 PAAAGRAV------VAPAPADRERVAAAAERLRPLPDPVALPGDTGTDVGPASASAA--L 243 Query: 260 PAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYF 319 P GL V AR +PF LL A+ VLV R A D VSVPVT R A+GYF Sbjct: 244 PDGLDDAVAGAARALGVTPFTWLLTAHAVLVARLFDADDAAVSVPVTARPAGTEDAIGYF 303 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMG-RDGMDLLV 378 G + R+T R ++F + V++ A A V +D V+ +P R G DG L Sbjct: 304 GTITVRRLTARPGESFRTAALRVQDDGAAALAFADVPVDAVIGALDPARAGDADGFARLA 363 Query: 379 RLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTI---ALDPDDVSVEFEYQQ-QLS 434 +L F+ R + G L+G+ L L A +P ++ A + +E +++ ++ Sbjct: 364 QLSFSTRAAVPGPDLEGIASAPLELATPGAQVPFEASVIRAAPGTPESRIEVRFRRGRVD 423 Query: 435 SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 V+ L L+ +A+P+ + +L + A D ++A G V+ + Sbjct: 424 PAAVEAYLTALPVLLAATVADPDADVRTLPLTTAPHADDLIAAGRGRAVDAGHPDTLTGL 483 Query: 495 XXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFI 554 ++DE +TY+E RRA LAR +G D++ L + I+F Sbjct: 484 WEAAVDRAPEALAL-LTDEDAVTYAEADRRAEVLARVLDRRGVQQGDVVALDLGGGIDFP 542 Query: 555 VAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSD 614 VA LAV+K GAAYLP+DPAYP ER L+ DARP+ V+ + VA A D +D Sbjct: 543 VAALAVMKLGAAYLPVDPAYPAERKRLLLGDARPRLVLDAAAVRVALDGAQGTVDT--AD 600 Query: 615 SDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSV 674 R+ RP AYVIYTSGSTGRPKGV V+H AIAEH+ G + ++ DR L SV Sbjct: 601 RTRITRTRPQDPAYVIYTSGSTGRPKGVVVAHAAIAEHLAGHLTAESLDPTDRLLLTGSV 660 Query: 675 SFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXX 734 SFDAS+ ++F TL GA L++ +P D Y+++L++R V+V Sbjct: 661 SFDASVFEVFGTLTAGATLVIGRPGGAADFGYISELVARHRVSVVHMVPSTLATYLMLPD 720 Query: 735 XXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVV 794 +WR +R +PVGGEALPG VADR A + N+YGPTEAVV +T +V V Sbjct: 721 AARWRSVRWIPVGGEALPGGVADRARAVLGARISNNYGPTEAVVAATGRMVDEPRAGETV 780 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGM 854 PIG P YVLD L PVPD + GELYLGG QLA GYLG P TA +F+ADP+ G Sbjct: 781 PIGGPTPGTALYVLDRALTPVPDGIAGELYLGGEQLALGYLGDPVATASKFVADPWRSGG 840 Query: 855 RLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA-EET 913 R+YRTGD VRR G+LEF+GR D+QVKI GFRIE GEV +V++ V VVA ++ Sbjct: 841 RMYRTGDRVRRRADGDLEFLGRTDDQVKIHGFRIEPGEVAAVLSGLEGVGGAAVVAVDDP 900 Query: 914 EAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPA 973 GP LAAYL P A+VD+ + A A+P ++VP A+ V+ +P+ +GKL R ALPA Sbjct: 901 VTGPALAAYLCP--AEVDVAAVAAAAERALPAHLVPSAYVVLDALPIGPNGKLARSALPA 958 Query: 974 PTPIATRRYREPETATERWICSIFAQLFGR--QRVGAEDSFFGLGGHSLLAARLVAQIRA 1031 P A R P TATER + + A+L R + A DSFF LGGHSLL RLVAQ+RA Sbjct: 959 PQRAAASGGRSPATATERTVAAAVARLLDRPATEIAATDSFFVLGGHSLLVTRLVAQLRA 1018 Query: 1032 EFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSAR 1091 E G++L+VR +FD PT +AA +D A ++ L P AR + Sbjct: 1019 ESGIELSVRAVFDGPTVEQIAAA------------IDVGAGGELRL-PLLAR----HATL 1061 Query: 1092 PQRLPLSHSQLAAWFQYR----IEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEA 1147 P +PL+ SQ + WF ++ A + A+R +GP RH++ Sbjct: 1062 PDTVPLTASQRSIWFAAALAAGVDAAPGAGVIEAAVRLDGPVDAEALAAALGDVVARHDS 1121 Query: 1148 LRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLV 1207 LRT F +GVP V S T +L + +D + L R F E P+L+A LLV Sbjct: 1122 LRTVFSTDDGVPTARVLGSWTPELPTVRVAEDPAGARAAFLAR-PFPLEGAPMLRAQLLV 1180 Query: 1208 LGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRN 1267 G T VL ++VHH+V+DH S+EI+ DDL AYRAR AP +FAD+A+WQ Sbjct: 1181 TGTAT-VLQVVVHHLVTDHRSMEILVDDLFAAYRARTL-GAPVAAPPAHRFADHALWQAE 1238 Query: 1268 TFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLG-KRGEVVQFSVPAARRAALTQL 1326 F S G+ +D L LP +I D R L RG F V A RA L ++ Sbjct: 1239 VFGSESGRAAVDAVAAGLRDLPGQIPALHDHPRRAELTLTRGHRAVFHVEPALRARLREV 1298 Query: 1327 AERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDL 1386 A+R+GATEF+L AALAVVLH++ GG DIA+G+ +AR EPA + GL AN+VVLRT + Sbjct: 1299 AQRHGATEFVLADAALAVVLHRVAGGRDIAIGTAASARTEPALDAMAGLIANMVVLRTTV 1358 Query: 1387 SGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWAL 1446 + TL +L +R A Q++P E +V+A+ P R RNPLFQ +L+ R + L Sbjct: 1359 RPESTLADVLDSARSAAALAFDRQQVPFELVVDAVAPERGPGRNPLFQTVLHVRDDAAVL 1418 Query: 1447 VPRDLT-GRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEPXXXXXXX 1505 PR + G G T LP++F+VAL+ LA+ + TP G D VIA +Y Sbjct: 1419 APRTVAPGLGATR---LPMDFDVALVDLAVSLFGTPDGGYDGAVIAGPAVYTAATAARLA 1475 Query: 1506 XXXXXXXXXXXXXXXXXXSAVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXETERRLTA 1565 + + + + Sbjct: 1476 DAVARVLAAFVDPATRVDAVLPELGVRTEPVAPLLDAAADCARTDFGTTGSALSAEEALS 1535 Query: 1566 MLEELL-EITGI---DRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAELA 1621 L ++L E+ G+ D+NYFA+GGDS+ +++++A+A A+G+P P +VF T+ EL Sbjct: 1536 QLLDILSELLGVPGITADDNYFAVGGDSVTSLQFAARATAIGVPVTPQLVFATATLGELV 1595 Query: 1622 AAVDAANGEPVVE-------------ADPPPAQEYTPMSASGLAPDALAKLSASW 1663 AA AA P A P MSASGL D LA L+A+W Sbjct: 1596 AAATAAGPGPATPDGADAAAPASTTGAAPVSTTGAAAMSASGLDADQLAALTAAW 1650 >tr|Q5YPH6|Q5YPH6_NOCFA Tax_Id=37329 SubName: Full=Putative non-ribosomal peptide synthetase;[Nocardia farcinica] Length = 5961 Score = 824 bits (2129), Expect = 0.0 Identities = 558/1507 (37%), Positives = 764/1507 (50%), Gaps = 92/1507 (6%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS Q+RMWFL D D N+ A R+ G +D L AV D+VARH ILRT Y Sbjct: 2193 RVPLSYAQQRMWFLNRFDADSTANNLTAALRITGPLDVTALAAAVTDLVARHEILRTRYP 2252 Query: 101 VDTEGEPYQVFS-DDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 G Q+ S +D V RE+L + ++ LAA RPFD+T PLR+ Sbjct: 2253 EADGGGYQQICSVEDSGVALEREELAA---DAVDARVRELAA----RPFDVTAHPPLRLH 2305 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-----------LPINDPAAQFL 208 ++R A+E VL++ +HHI D S +L AY+ LP+ Sbjct: 2306 LLRVAAEEHVLVVGLHHIAADGWSVAPLTRDLLRAYDSRRAGTAPDWAPLPVQYADYTLW 2365 Query: 209 SVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAG 262 E+L +A P A + +W+ L P + R LPA Sbjct: 2366 QRELLGTAADPDSLPAAQLAFWSAELAGLPDLLELP-TDRPRPAEASGHGARHRCALPAS 2424 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 + + A +S FMVL AA+ ++ +G+ D +V PV R AA L G F N Sbjct: 2425 TVAELRALADATDSSLFMVLHAAFATVLAALSGSRDIVVGTPVAGRGEAALDELVGMFVN 2484 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLG 381 TL+LR R F V VRET L F H V +R+V P R V L Sbjct: 2485 TLVLRTEVRPDLAFAQLVAAVRETDLRAFEHADVPFERLVEALEPRRSAARHPLFQVMLD 2544 Query: 382 FNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQM 441 N A + + G + L L AA L L++ D + F Y L Sbjct: 2545 LNNTAPAAPVDMAGTNITPLELDDAAAKFDLQLSLTETADGMDAVFTYATDLFDEATVAS 2604 Query: 442 LVHYLQLV-DKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM-PATTMVKXXXXXXX 499 L+LV D A+P+ + ++D+L A ER +L + + + PA T++ Sbjct: 2605 FATRLRLVLDAVCADPDVRIGAIDLLTAAERTVLLRERNATARPLGPAATLIDLFEEQAE 2664 Query: 500 XXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLA 559 V ++ LTY E R +RLAR + G GPE +GL M SIE +V M A Sbjct: 2665 RTPDAVAV--VFEDEHLTYREFAARVHRLARLLVAHGVGPERTVGLGMHRSIELVVGMYA 2722 Query: 560 VLKAGAAYLPIDPAYPDERIDYLITDARPQTVI--GRPELDVAERAAADNS--------D 609 VL AG AY+P+DPA+P ER+ +++ ARP V+ GR L+V A D D Sbjct: 2723 VLAAGGAYVPLDPAHPAERLAHILDTARPVCVLTRGRDGLEVTGPAVLDLDLLDTTGYPD 2782 Query: 610 LPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWL 669 L+D+DR PLRP AYV++TSGSTGRPKGV + H AI ++ E+ + A D L Sbjct: 2783 TALTDADRRAPLRPARPAYVLFTSGSTGRPKGVTIEHAAIVNRLRWMQDEYRIDARDVVL 2842 Query: 670 QFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXX 729 Q + V+FD S+ + F L +GA+L++ +PD D Y+A+LI+ VTV Sbjct: 2843 QKTPVTFDVSVWEFFWPLQVGARLVLARPDGHRDPRYLAELITAEAVTVAHFVPAMLAVF 2902 Query: 730 XXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSH 789 Q LR V GEALP A R A + N YGPTEA V TH VT + Sbjct: 2903 VAEPAAAQCHSLRAVFCSGEALPPAPAHRLRALTGAAVHNLYGPTEAAVDVTHHEVTDAD 2962 Query: 790 GARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADP 849 + VPIG P N YVLD++L PVP V GELYL G QLARGY GRP LTA RF+ADP Sbjct: 2963 -TQSVPIGSPVANTRVYVLDDRLRPVPAGVPGELYLAGVQLARGYAGRPDLTADRFVADP 3021 Query: 850 FNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVV 909 F PG R+YRTGD VR + GELE++GR D QVK+RG RIE GE+E+ +T V +VV Sbjct: 3022 FTPGARMYRTGDRVRWSAAGELEYLGRTDFQVKVRGMRIEPGEIEAALTELDGVDQAVVV 3081 Query: 910 AEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRR 969 A + L AYL+P A VD + +R A +P Y+VP AF ++ P+ SGKLDR Sbjct: 3082 ARDEH----LVAYLIP-AGPVDPDAVRVALARRLPAYLVPAAFVLLDAFPLNASGKLDRT 3136 Query: 970 ALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQI 1029 ALPAP A YR P TA +R + ++FA L G +RVG +D FF LGG+SL A R+VA++ Sbjct: 3137 ALPAPV-FAAAAYRAPVTAVQRQVAAVFADLLGAERVGLDDDFFALGGNSLTATRVVARL 3195 Query: 1030 RAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKS 1089 A + VR +FDAPT GLAAR+ PL ARP Sbjct: 3196 GAALDAQVPVRALFDAPTVEGLAARVA-------------------PLCGSGARPALTAR 3236 Query: 1090 ARPQRLPLSHSQLAAWF--QYRIEGAREEF-NMPLALRFEGPXXXXXXXXXXXXXXXRHE 1146 RP R+PLS +Q WF ++ +G + N+P+ALR G RHE Sbjct: 3237 PRPDRIPLSAAQQRIWFLNRFLADGPGDAVSNIPVALRLTGELDAAALTAALHDVVTRHE 3296 Query: 1147 ALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL---LQA 1203 +LRT PYQ+V P+ + +R + DD+ +L + P + L+A Sbjct: 3297 SLRTVHPADVAGPYQVVRPAGEQRFDLRPVAVTA-DDLPARLAARIAEPFDLTVETPLRA 3355 Query: 1204 NLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAV 1263 +L L PD HV+L+++HHI +D SL + DL+ AY AR AP W LP+Q+ADYA+ Sbjct: 3356 DLFALAPDEHVVLVVLHHIGADGFSLGPLAADLMTAYTARRAGVAPAWTPLPVQYADYAL 3415 Query: 1264 WQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAA 1318 WQ + EL +WR AL GLP+++ + TDR RP V RG + + A Sbjct: 3416 WQAELLGDDADPGSRAHRELAFWRAALDGLPEQLDLPTDRPRPAVASHRGATHRLRIDAD 3475 Query: 1319 RRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFAN 1378 + L +LA + T F AALAV+L +L G DIA+G+PVA R + +VG+F N Sbjct: 3476 LHSELRELARKRDTTLFATVHAALAVLLARLSGTADIAIGTPVAGRGDQGLDGVVGMFVN 3535 Query: 1379 VVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLN 1438 +VLR+ + ++L +R LDAL+H +LP ERLVE L P RA +R+PLFQ L Sbjct: 3536 TLVLRSHIDPRDRFEAVLDETRRRDLDALSHPDLPFERLVEVLAPARARNRHPLFQVALT 3595 Query: 1439 FRGEDWALVPRDLTGRGETTVVPLPVN-----FEVALLFLAIGMSVTPSGE---LDVQVI 1490 +++ + P +L G V PLP++ F++ L + P G +D+++I Sbjct: 3596 M--QNFTVPPLELPG---LRVRPLPLDAVAAEFDLQFSVLENASADDPDGRADGMDIEII 3650 Query: 1491 ANADLYE 1497 DL++ Sbjct: 3651 YATDLFD 3657 Score = 707 bits (1826), Expect = 0.0 Identities = 517/1464 (35%), Positives = 708/1464 (48%), Gaps = 94/1464 (6%) Query: 40 ERYRLSDGQRRMWFLQTM---DPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILR 96 +R LS Q+R+WFL P D NI VA RL G +D L A++DVV RH LR Sbjct: 3240 DRIPLSAAQQRIWFLNRFLADGPGDAVSNIPVALRLTGELDAAALTAALHDVVTRHESLR 3299 Query: 97 TTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPL 156 T + D G PYQV G +R DL P A + + A PFDLT E PL Sbjct: 3300 TVHPADVAG-PYQVVRP---AGEQRFDLR--PVAVTADDLPARLAARIAEPFDLTVETPL 3353 Query: 157 RITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAA 205 R + DE V+L+V+HHI D S +L AY LP+ Sbjct: 3354 RADLFALAPDEHVVLVVLHHIGADGFSLGPLAADLMTAYTARRAGVAPAWTPLPVQYADY 3413 Query: 206 QFLSVEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPC----RRAQRRVRP 258 E+L + A P ++ +W L P R A R+R Sbjct: 3414 ALWQAELLGDDADPGSRAHRELAFWRAALDGLPEQLDLP-TDRPRPAVASHRGATHRLR- 3471 Query: 259 LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALG 317 + A L S + + ARK + F + AA VL+ R +G +D + PV R G +G Sbjct: 3472 IDADLHSELRELARKRDTTLFATVHAALAVLLARLSGTADIAIGTPVAGRGDQGLDGVVG 3531 Query: 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLL 377 F NTL+LR +D F + ++E R L +H + +R+V P R L Sbjct: 3532 MFVNTLVLRSHIDPRDRFEAVLDETRRRDLDALSHPDLPFERLVEVLAPARARN--RHPL 3589 Query: 378 VRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTI-----ALDPDD----VSVEF 427 ++ M+ + L L G+ VR L L AVAA L ++ A DPD + +E Sbjct: 3590 FQVALTMQNFTVPPLELPGLRVRPLPLDAVAAEFDLQFSVLENASADDPDGRADGMDIEI 3649 Query: 428 EYQQQLSSV-LVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMP 486 Y L V + + Q++ A+ + + +L A E+ L + Sbjct: 3650 IYATDLFDADSVAVLARRFTQVLAAVAADATVVVGDIQLLSAEEQYRTLHDWAATGRDRA 3709 Query: 487 ATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLR 546 A + L+Y EL R+NRLAR + G GPE ++ + Sbjct: 3710 AGDRTLPDRFAAAARRDPAATAVRAAATTLSYGELDARSNRLARRLVAAGVGPETLVAVA 3769 Query: 547 MANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI------------GR 594 + S E +VA+LAVLKAG YLPIDP YP +RI+Y+I DARP + G Sbjct: 3770 LPRSAELVVALLAVLKAGGGYLPIDPDYPADRIEYMIDDARPICALTAPGTALARDWFGG 3829 Query: 595 PELDVAERAAADN--SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEH 652 P LDV ER A + PL+D+DR PLRP H AYVIYTSGSTGRPKGV + H + Sbjct: 3830 PVLDV-ERDADPRYYASTPLTDADRRAPLRPEHTAYVIYTSGSTGRPKGVVIPHRNVVRL 3888 Query: 653 VQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLIS 712 + + D W F S +FD S+ +++ L G ++V +L+ Sbjct: 3889 LDNTRELFGFGPHDVWTMFHSYAFDFSVWELWGALLHGGSVVVVDYFTSRSPEQFRELLV 3948 Query: 713 RRGVTVXXXXXXXXXXXXXXXXXXQWRQ--LRHVPVGGEAL-PGEVADRFAGYFDA-ELR 768 VTV + + LR V GGEAL P + Y DA L Sbjct: 3949 GERVTVLDQTPSAFYQLVAADTAAEPAEYALRWVIFGGEALEPQRLGGWLRRYPDAPRLV 4008 Query: 769 NHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGS 828 N YG TE V ++ + GA V IG + VLD +L PVP V GE+Y+ G Sbjct: 4009 NMYGITETTVHVSYRAIDAGTGAASV-IGGAIPGLTVRVLDPRLRPVPVGVPGEIYVSGG 4067 Query: 829 QLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFR 887 QLARGYLGRP LTA RF+ADP+ P G R YR+GDL R GELEF+GRAD+QV +RGFR Sbjct: 4068 QLARGYLGRPGLTAGRFVADPYGPAGARAYRSGDLARWTATGELEFLGRADQQVNLRGFR 4127 Query: 888 IELGEVESVITTHPAVRH-CLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEY 946 IELGE+E+ + P V +VV + + YLV A VD E+R +PE+ Sbjct: 4128 IELGEIEAALLAEPEVTEAAVVVRSDLVDEARIVGYLV-TAGPVDTAELRERVRRTLPEH 4186 Query: 947 MVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFG--RQ 1004 MVP A I IP+TV+GKLDR ALPAP AT YR P T E + ++A++ G Q Sbjct: 4187 MVPAALVEIDRIPLTVNGKLDRAALPAPVFTAT-AYRAPATLVEEIVAGVYAEVLGLTDQ 4245 Query: 1005 RVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFE 1064 RVGA+D FF LGG SLLAA+ A+I ++VRT+F+AP A LAA Sbjct: 4246 RVGADDDFFALGGSSLLAAKAAARIGTALDRQVSVRTLFEAPRVAELAAA---------- 4295 Query: 1065 LDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALR 1124 ++ AA RP V ARP RLPLS +Q WF R + A + +P+ALR Sbjct: 4296 --VEAAAA--------ATRPPLVAGARPARLPLSPAQQRMWFLNRYDAASTAYTIPVALR 4345 Query: 1125 FEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDV 1184 G RHEALRT + E +G P Q + P+ + + Sbjct: 4346 LRGALDPAALRAALDDLVARHEALRTRYPEVDGEPVQEILPAGPALPDAETVAESALPQR 4405 Query: 1185 STQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARL 1244 +L F + ++ LL + HVL+ +HHI +D +S+ DL+ AY AR+ Sbjct: 4406 IRELVHAPFDVTAEVPVRLRLLRVAETEHVLVGALHHIAADGSSIVPFVRDLMTAYTARV 4465 Query: 1245 QHNAPQWDILPIQFADYAVWQR-----NTFESNWGQTELDYWRDALAGLPDEISVATDRA 1299 +AP W +Q+ADYA+WQR + ++ ++ YW ALAGLPD++++ TDR Sbjct: 4466 ADSAPCWQPPAVQYADYALWQRALLGDESDPASRAAEQIGYWTRALAGLPDQLALPTDRP 4525 Query: 1300 RPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGS 1359 RP RG+ V +V A A L L +GAT FM+ AA A +L +L G DIA+G+ Sbjct: 4526 RPATQSLRGDTVSVAVDARLHAGLVALGRAHGATLFMVVHAAFAALLARLSGTADIAVGT 4585 Query: 1360 PVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVE 1419 PVA R ++G+F N +VLRT + +L +R L A AH ++P ERLVE Sbjct: 4586 PVAGRGAAELDDVIGMFVNTLVLRTVVDDGAPFTELLDRARAADLAAFAHADVPFERLVE 4645 Query: 1420 ALNPPRALSRNPLFQNMLNFRGED 1443 L+P R+ +R+PLFQ +F+ + Sbjct: 4646 VLDPARSTARHPLFQVGFSFQNHE 4669 Score = 706 bits (1823), Expect = 0.0 Identities = 522/1532 (34%), Positives = 743/1532 (48%), Gaps = 142/1532 (9%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++ DD ++ V RL G ++ L A+ DV+ RH ILRT + VDT Sbjct: 1131 LSPAQQRIWFLSRLERDDPRYHMPVLLRLDGALEVTALRAALADVLDRHEILRTVFPVDT 1190 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEF--------GRPFDLTNELP 155 +G +Q LP E +E + A E RPF L E+P Sbjct: 1191 DGAAHQQI---------------LPATTVELPVEPVEAAELTAAVRVFAARPFQLETEIP 1235 Query: 156 LRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPA 204 +R T+ R DE L LV+HHI D S V + + AY LP+ Sbjct: 1236 VRATLFRLGPDEYALALVLHHIAADGLSLPVLAADTATAYAARRDGGAPQWAPLPLQYAD 1295 Query: 205 AQFLSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXG-------VSGANPCRRAQR 254 E L + A P + + +W L GA R Sbjct: 1296 YALWQRERLGDPADPGSLAARQLAFWTAALDGAPDHLELPADRPRPAIADGAGATYRID- 1354 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 +PA L +RV + AR+ A+ FMVL AA VL+ R +G D ++ PV R A Sbjct: 1355 ----IPAELHTRVAELAREEGATVFMVLHAALAVLLARLSGVDDVVIGAPVGGRDAAGLD 1410 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 AL G F NT+ LR F + + VRE LA FAH V +++V P R Sbjct: 1411 ALVGMFVNTVPLRTPVDRSAPFHTLLRAVREHDLAAFAHADVPFEQLVEVLRPAR----- 1465 Query: 374 MDLLVRLGFNMRKSAG-----GLALDGVVVRQLGLGAVAAHLPLSLTIALD--------- 419 L F + SA +AL GV VR + L++ + Sbjct: 1466 -SLARHPVFQVALSAAVTGDLAVALPGVAVRTSTVETGVTKFDLAVEVTERFAGAGRGEG 1524 Query: 420 --PDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA 476 P ++ EF Y L + V +++L+ A A P+ P+ +L +L E ++ Sbjct: 1525 PAPAGITAEFTYATALFDAATVAATAARFVRLLAAATAGPDLPVGALPLLDGAEYAALTT 1584 Query: 477 QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQG 536 + G A T + V+ ELTY EL + + RLAR + +G Sbjct: 1585 RWAGPA----AATTLLPDLFAAAAATAPERVAIVAAGRELTYRELDQTSARLARALMARG 1640 Query: 537 FGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITD----------A 586 GP+D++ + + S EF+ A+ A+ KAGAA++P+DPAYP ERI++++ D A Sbjct: 1641 VGPDDVVAVGIPRSPEFVTAVWAIAKAGAAWVPVDPAYPAERIEHMLRDSGAVLGLTVGA 1700 Query: 587 RPQTVIGRPE---LDVAERA--AADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKG 641 + G+P LD E A P+ D++R+RPLRP +LAYVIYTSGSTG PKG Sbjct: 1701 VRADLPGQPHWLVLDDVEFGFECARFGGEPVRDAERVRPLRPHNLAYVIYTSGSTGTPKG 1760 Query: 642 VAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIV-PKPDA 700 V V+ +A A + + A R L S SFD ++A++ + A L++ P+ Sbjct: 1761 VLVTQAGVAGFAAEQTARYPIDATARVLHVGSPSFDITVAELLMAFDSAATLVIAPEEAR 1820 Query: 701 FGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFA 760 FG + +L++ + VT + LR + GGEA P E+ R+ Sbjct: 1821 FG--RELVELLAAQRVT----HSIMTPSGALTIDPAEVPDLRVLVAGGEACPPELVRRWH 1874 Query: 761 GYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVI 820 L + YGPTEA V + R V IG P R V +VLDE+L PVP V Sbjct: 1875 AA-GRRLVDAYGPTEATVAVD--ISDRLEPGRPVTIGRPLRGVREWVLDERLRPVPVGVA 1931 Query: 821 GELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCG---ELEFVGRA 877 GELY+ G+QLARGY GR TA+RF+A P+ PG R+YRTGDLVR ELE++GR Sbjct: 1932 GELYVAGAQLARGYHGRRATTAERFVACPWAPGERMYRTGDLVRWTLASGGRELEYLGRN 1991 Query: 878 DEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEA-GPMLAAYLVPAAAQ-VDLEEI 935 D QVK+RGFRIELGE+E+ + P V H +V A G LAAY+VP+ +D ++ Sbjct: 1992 DAQVKVRGFRIELGEIEAALAARPGVAHAVVTVHRDPARGDQLAAYVVPSGGHPLDAGDL 2051 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 +A + ++VP A V+ +P+T +GKLDR ALPAP R YR P T ER + + Sbjct: 2052 KAGLRTRLAPHLVPAAITVLDTLPLTPNGKLDRAALPAP-EFGVRAYRAPATDVERTVAA 2110 Query: 996 IFAQLFG---RQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA 1052 +A++ G VG +D FF LGG+SL+A RLVA++ A + + VR +F+AP+ AGLA Sbjct: 2111 TYAEVLGVRAEPGVGRDDDFFELGGNSLIATRLVARLGAALDMTVPVRAVFEAPSVAGLA 2170 Query: 1053 ARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEG 1112 A L + P RARP RP R+PLS++Q WF R + Sbjct: 2171 ALLAHGVGSGARA-------------PLRARP------RPPRVPLSYAQQRMWFLNRFDA 2211 Query: 1113 AREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIV--HPSRTVQ 1170 N+ ALR GP RHE LRT + E +G YQ + V Sbjct: 2212 DSTANNLTAALRITGPLDVTALAAAVTDLVARHEILRTRYPEADGGGYQQICSVEDSGVA 2271 Query: 1171 LAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLE 1230 L + D D +L F + P L+ +LL + + HVL++ +HHI +D S+ Sbjct: 2272 LEREELAADAVDARVRELAARPFDVTAHPPLRLHLLRVAAEEHVLVVGLHHIAADGWSVA 2331 Query: 1231 IVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDAL 1285 + DL+ AY +R AP W LP+Q+ADY +WQR + +L +W L Sbjct: 2332 PLTRDLLRAYDSRRAGTAPDWAPLPVQYADYTLWQRELLGTAADPDSLPAAQLAFWSAEL 2391 Query: 1286 AGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVV 1345 AGLPD + + TDR RP G + ++PA+ A L LA+ ++ FM+ AA A V Sbjct: 2392 AGLPDLLELPTDRPRPAEASGHGARHRCALPASTVAELRALADATDSSLFMVLHAAFATV 2451 Query: 1346 LHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLD 1405 L L G DI +G+PVA R E A +LVG+F N +VLRT++ D ++ R+T L Sbjct: 2452 LAALSGSRDIVVGTPVAGRGEAALDELVGMFVNTLVLRTEVRPDLAFAQLVAAVRETDLR 2511 Query: 1406 ALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVN 1465 A H ++P ERLVEAL P R+ +R+PLFQ ML+ A P D+ G T + PL ++ Sbjct: 2512 AFEHADVPFERLVEALEPRRSAARHPLFQVMLDLNNTAPA-APVDMAG---TNITPLELD 2567 Query: 1466 FEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 A L + ++ T G +D DL++ Sbjct: 2568 DAAAKFDLQLSLTETADG-MDAVFTYATDLFD 2598 Score = 687 bits (1772), Expect = 0.0 Identities = 522/1541 (33%), Positives = 727/1541 (47%), Gaps = 138/1541 (8%) Query: 20 IAESGLAAEQSS--DQPGICPGER---YRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAG 74 +AE A E ++ +P + G R LS Q+RMWFL D I VA RL G Sbjct: 4289 VAELAAAVEAAAAATRPPLVAGARPARLPLSPAQQRMWFLNRYDAASTAYTIPVALRLRG 4348 Query: 75 LVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHER 134 +D L A++D+VARH LRT Y + +GEP Q + + G D + E+ + Sbjct: 4349 ALDPAALRAALDDLVARHEALRTRYP-EVDGEPVQ---EILPAGPALPDAETVAESALPQ 4404 Query: 135 QIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAA 194 +I L PFD+T E+P+R+ ++R E VL+ +HHI D S F +L A Sbjct: 4405 RIRELVH----APFDVTAEVPVRLRLLRVAETEHVLVGALHHIAADGSSIVPFVRDLMTA 4460 Query: 195 YNDLPIND------PAAQFLSVEVLQNS--------AAPSVADVGYWAETLRXXXXXXXX 240 Y + PA Q+ + Q + A+ + +GYW L Sbjct: 4461 YTARVADSAPCWQPPAVQYADYALWQRALLGDESDPASRAAEQIGYWTRALAGLPDQLAL 4520 Query: 241 XG--VSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASD 298 A R + A L + + R A+ FMV+ AA+ L+ R +G +D Sbjct: 4521 PTDRPRPATQSLRGDTVSVAVDARLHAGLVALGRAHGATLFMVVHAAFAALLARLSGTAD 4580 Query: 299 FLVSVPVTERSGAAAG-ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGI 357 V PV R A +G F NTL+LR FT ++ R LA FAH V Sbjct: 4581 IAVGTPVAGRGAAELDDVIGMFVNTLVLRTVVDDGAPFTELLDRARAADLAAFAHADVPF 4640 Query: 358 DRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTI 416 +R+V +P R L ++GF+ + G L L G+ V ++ + A L L Sbjct: 4641 ERLVEVLDPARS--TARHPLFQVGFSFQNHERGTLELPGLTVEEIEFDSGVAQFDLHL-F 4697 Query: 417 ALD-------PDDVSVEFEYQQQLSSVLVDQMLVHYL-QLVDKALAEPERPLSSLDILGA 468 ALD P V + Y L + L +++ + + +P+ + LD+LG Sbjct: 4698 ALDRYGSGGAPQGVELVLGYATDLFEASTARRFADQLHRVLAEVVRQPQVVVGDLDLLGP 4757 Query: 469 GERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRL 528 R+ +L + +PA T+ LTY E ANRL Sbjct: 4758 AGRE-LLGTWNATAHPLPAATLADLGARQAAATPDAVAVLDAHQGRTLTYREFDAAANRL 4816 Query: 529 ARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARP 588 AR I G GPE + L + S+ +VAM AV++AG AY+P+DP +P ERI +++ A P Sbjct: 4817 ARRLIRAGVGPEQTVVLALRRSVALVVAMHAVVRAGGAYVPVDPDHPAERIAHILDTAAP 4876 Query: 589 QTVIGR---------PELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRP 639 V+ P LD+ AA D P+ D +R+RPLRP H AYVI+TSGSTGRP Sbjct: 4877 VCVLATGDLPFDTALPVLDIDGGAALP--DDPIRDEERVRPLRPEHPAYVIFTSGSTGRP 4934 Query: 640 KGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPD 699 KGVAV H A+A ++ AE+ + + D L + +FD S+ + + L G +L+V P Sbjct: 4935 KGVAVPHAAVANQIRWLCAEFGLGSADACLLKTPATFDLSVWEFWGPLLSGGRLVVTAPG 4994 Query: 700 AFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVA--- 756 D + DL+ R +T+ LRHV GEALP VA Sbjct: 4995 DERDPDRLRDLLDRHAITLLCTVPSMLAMLLGAAAGLPGA-LRHVLAIGEALPPAVAADF 5053 Query: 757 -DRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPV 815 DR AG A L N YGPTEA V T V VPIG P N YVLD ++ PV Sbjct: 5054 LDRAAGT-GAALHNLYGPTEAAVSITAHEVR-ERPRHTVPIGTPAWNSRLYVLDRRMRPV 5111 Query: 816 PDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVG 875 P V GELYL G QLARGY P LTA RF+ADPF+ G R+YRTGD+VRR G LE++ Sbjct: 5112 PVGVAGELYLAGVQLARGYQAAPALTAGRFVADPFDRGARMYRTGDIVRRRADGSLEYLE 5171 Query: 876 RADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYL----------- 923 RAD QVKI GFRIELG++ES + P VR + +A + AG L AY Sbjct: 5172 RADFQVKIGGFRIELGDIESALLALPGVRAAVALARTDGAAGARLVAYAAVDGVLSSATS 5231 Query: 924 ------VPAAAQVDLE------------EIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGK 965 PAA + E E+RA +P YMVP A +P +P+T +GK Sbjct: 5232 GSSNGGAPAADATEREDDAVSATTRIAAELRAELRERLPGYMVPAAVMALPALPLTGNGK 5291 Query: 966 LDRRALPAPTPIATRRYREPETATERWICSIFAQLFG--RQRVGAEDSFFGLGGHSLLAA 1023 +DR LP P A +REP +R + + FA++ G +RVGAE FF LGG+SLLA Sbjct: 5292 VDRARLPEPV-FAEGAFREPRGPVQRLVAATFAEVVGIPPERVGAESDFFDLGGNSLLAT 5350 Query: 1024 RLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRAR 1083 +L A++ A GV + V +F+APT LA RL LD AR Sbjct: 5351 KLAARLGAARGVRVPVAAVFEAPTVEALARRLDA---------LDG-----------AAR 5390 Query: 1084 PGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXX 1143 P V+ +PL+ +Q W R+ +N+P ALR G Sbjct: 5391 PPLVRRTGTAPVPLAPAQQRMWVVNRLAPDSAAYNIPAALRLTGDLDHAALTAAVRDVLD 5450 Query: 1144 RHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV---FTPESGPL 1200 RH LRT + + P Q V P + + + D++ T+L V F + P Sbjct: 5451 RHATLRTRYPDGPEGPIQEVLPVAALAPDLTPVPV-RADELPTRLAEFVSRGFDVAAAPP 5509 Query: 1201 LQANLLVL---------GPDT----HVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHN 1247 + L GP + HVL+++VHHI +D S+ + DL+ AY R + Sbjct: 5510 ARIALFACADEHGGGHDGPPSTSTEHVLVVVVHHISADGYSVLPLTRDLMRAYAERAAGH 5569 Query: 1248 APQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPR 1302 AP W L I +ADY+VWQ + + +L YWR LA P+ +++ TDR RP Sbjct: 5570 APGWAPLAITYADYSVWQHDLLGAPDAPDSAAAAQLAYWRGELASAPELLALPTDRPRPP 5629 Query: 1303 VLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVA 1362 RG V +V A AL ++A +G T F + +ALAV+L KL GGTDI +G PVA Sbjct: 5630 HRDMRGASVDVTVDAELTGALDRVARTHGTTLFTVLHSALAVLLAKLSGGTDICVGVPVA 5689 Query: 1363 ARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALN 1422 R E LVG+F N VVLRT++ +L + +L AL+H ++P E++V+AL Sbjct: 5690 GRGERELDDLVGMFVNTVVLRTEIEAKAGFADLLAQASRRMLGALSHADVPFEQVVDALG 5749 Query: 1423 PPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLP 1463 R+ + PLFQ M F+ V +L G + P P Sbjct: 5750 RTRSSAYTPLFQVMFTFQNMPPGTV--ELPGLAVEVIDPAP 5788 Score = 640 bits (1650), Expect = 0.0 Identities = 505/1537 (32%), Positives = 708/1537 (46%), Gaps = 143/1537 (9%) Query: 38 PGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRT 97 P + LS Q +W+ Q +DP V + + L G +D D L +V A A+ Sbjct: 41 PAAPFPLSPAQTGVWYAQLLDPQ-VPITVAQYVDLRGDLDVDLLQ----EVSAEAAL--- 92 Query: 98 TYG------VDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGR----- 146 YG + +G P+QV + +LT L H + AA E+ R Sbjct: 93 DYGSGFVRLCEIDGVPHQVVDPTLS-----RELTVLDLREHADPVA--AAHEWMRADAAA 145 Query: 147 PFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-------DLP 199 P DL + R ++R L HHI D V ++ Y P Sbjct: 146 PLDLLRDRLTRGAILRVGTRRWFWYLRAHHIVLDGYGALVNTQRVAERYTARVHGTEPAP 205 Query: 200 IND-PAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRV-- 256 + P + ++ E ++ AD +WA + + G R A V Sbjct: 206 VRPAPLPELVAAEQAYRDSSRFAADRAHWASRVAGLDGVT---SLDGRVAPRAASNLVVG 262 Query: 257 RPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG-A 315 R LP L R+ A ++ VL+AA+G + R T D ++S+PVT R+ AA + Sbjct: 263 RALPQALVERMNTVAADQDSTIATVLIAAFGGYLGRLTDRPDVVLSLPVTARTTAAMRRS 322 Query: 316 LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMD 375 G N + LR+ + + + R HQ + + R+A E GR Sbjct: 323 TGMMSNIVPLRLPV-GEVRWAELLRATRVELAGALRHQRYRHEDIRRDA--EHDGRPAHR 379 Query: 376 LLVRLGFNMRKSAGGLALDGVVVRQ--LGLGAVAAHLPLSLTIAL-DPDDVSVEFEYQQQ 432 L N+ L L R L G V LS+ + + D V V+FE Sbjct: 380 ALFGPLANIMLFGRDLTLGTTTGRYHVLSTGPVE---DLSMNVYYGERDSVHVDFEANPN 436 Query: 433 LSSVLVDQMLVH---YLQLVDK-ALAEPERPLSSLDILGAGERD--------------SV 474 L S D++ H +L +D+ A A P+ L ++ + E + ++ Sbjct: 437 LYST--DELARHHARFLGYLDRLADAGPDTALGAVPVTSELEFEVSTRIWNATDVDVRAL 494 Query: 475 LAQ------------------SHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAEL 516 LA G P T + + L Sbjct: 495 LAPVRAGGSAVGGAASMCGPARQGASETAPPTLVSMFAAQVARTPDAVALRFAGAPPTVL 554 Query: 517 TYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPD 576 TY EL R +RLAR IG G GPE ++ L M S + ++AM AVL AG AY+P+DP +P Sbjct: 555 TYRELAGRVDRLARHLIGLGVGPETLVALHMRRSPDLVIAMYAVLSAGGAYVPLDPDHPA 614 Query: 577 ERIDYLITDARPQTVIGRPELDVAERAAA---DNSDL------PLSDSDRLRPLRPGHLA 627 ER +++ A P V+ E ++ A D+ DL P+ D +R RPLRP + A Sbjct: 615 ERTAHILATAAPACVLTAGETRLSADAPVVHLDDLDLSAHPDGPVWDRERRRPLRPRNPA 674 Query: 628 YVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTL 687 YVI+TSGSTG PKGVAV+H AI + + + + LQ + +FD S+ + F L Sbjct: 675 YVIFTSGSTGAPKGVAVTHEAIVNRLVWMQQTYRLGPGEVVLQKTPATFDVSVWEFFWPL 734 Query: 688 FLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVG 747 +GA+L++ PD D +Y+ +I GVT + LR V Sbjct: 735 QVGAELVLAAPDGHRDPAYLRRVIDDYGVTTAHFVPSMLEAFLAGQDIARAGTLRRVFAS 794 Query: 748 GEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYV 807 GEALP A R A L N YGPTEA V T VT + VPIG P N +V Sbjct: 795 GEALPAATAQRLRLLTGARLHNLYGPTEAAVDVTFHEVTDA-DTDAVPIGAPVFNTRLHV 853 Query: 808 LDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRN 866 LD +L PVP GELYL G QLARGY+ RP L+A+RF+ADPF P G R+YRTGDLVR N Sbjct: 854 LDSRLRPVPVGAPGELYLSGVQLARGYVARPGLSAERFVADPFGPAGTRMYRTGDLVRWN 913 Query: 867 HCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGP----MLAAY 922 GELE++GR D QVK+RG RIELGE+E+V+ V +V+ + P L AY Sbjct: 914 TSGELEYLGRTDFQVKLRGLRIELGEIEAVLAGVDGVVRAVVLVRDDVGSPALGEQLVAY 973 Query: 923 LVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRR 981 +V A V E++RA A+P YMVP A+ V+ E+P+ SGKLDR ALPAP Sbjct: 974 VVAAEPDAVGAEQLRAAALRALPAYMVPAAYVVLDELPVNASGKLDRAALPAPARTVV-A 1032 Query: 982 YREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRT 1041 Y P T ER + +F ++ GR+RVG +D FF LGG+SL+A ++ A++ A+ L VR Sbjct: 1033 YAAPATPVERAVARVFGEVLGRERVGRDDDFFALGGNSLVATQVAARLSADLNCSLGVRE 1092 Query: 1042 IFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQ 1101 +F A T L A L+ER P R P RP +PLS +Q Sbjct: 1093 MFTATTVRDL-AELIERAG----------GTGGGPHRQLRVVP------RPPLVPLSPAQ 1135 Query: 1102 LAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFD-EHEGVPY 1160 WF R+E ++MP+ LR +G RHE LRT F + +G + Sbjct: 1136 QRIWFLSRLERDDPRYHMPVLLRLDGALEVTALRAALADVLDRHEILRTVFPVDTDGAAH 1195 Query: 1161 QIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVH 1220 Q + P+ TV+L V ++ E F E+ ++A L LGPD + L L++H Sbjct: 1196 QQILPATTVELPVEPVEAAELTAAVRVFAARPFQLETEIPVRATLFRLGPDEYALALVLH 1255 Query: 1221 HIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQ 1275 HI +D SL ++ D AY AR APQW LP+Q+ADYA+WQR + Sbjct: 1256 HIAADGLSLPVLAADTATAYAARRDGGAPQWAPLPLQYADYALWQRERLGDPADPGSLAA 1315 Query: 1276 TELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEF 1335 +L +W AL G PD + + DR RP + G + +PA + +LA GAT F Sbjct: 1316 RQLAFWTAALDGAPDHLELPADRPRPAIADGAGATYRIDIPAELHTRVAELAREEGATVF 1375 Query: 1336 MLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSI 1395 M+ AALAV+L +L G D+ +G+PV R LVG+F N V LRT + ++ Sbjct: 1376 MVLHAALAVLLARLSGVDDVVIGAPVGGRDAAGLDALVGMFVNTVPLRTPVDRSAPFHTL 1435 Query: 1396 LVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---- 1451 L R+ L A AH ++P E+LVE L P R+L+R+P+FQ L+ A V DL Sbjct: 1436 LRAVREHDLAAFAHADVPFEQLVEVLRPARSLARHPVFQVALS------AAVTGDLAVAL 1489 Query: 1452 ------TGRGETTVVPLPVNFEVALLFLAIGMSVTPS 1482 T ET V + EV F G P+ Sbjct: 1490 PGVAVRTSTVETGVTKFDLAVEVTERFAGAGRGEGPA 1526 Score = 44.7 bits (104), Expect = 0.12 Identities = 27/69 (39%), Positives = 42/69 (60%), Gaps = 4/69 (5%) Query: 1558 ETERRLTAMLEELLEIT---GIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFE 1613 + ER + A E+L + G+ RD+++F LGG+S+IA + A+ G AL + P VFE Sbjct: 2103 DVERTVAATYAEVLGVRAEPGVGRDDDFFELGGNSLIATRLVARLGAALDMTVPVRAVFE 2162 Query: 1614 HMTIAELAA 1622 ++A LAA Sbjct: 2163 APSVAGLAA 2171 Score = 44.3 bits (103), Expect = 0.15 Identities = 33/97 (34%), Positives = 51/97 (52%), Gaps = 8/97 (8%) Query: 1560 ERRLTAMLEELLEITG--IDRDENYFALGGDSIIAIKWSAQAGAL-GLPFPPAMVFEHMT 1616 +R + A E++ I + + ++F LGG+S++A K +A+ GA G+ P A VFE T Sbjct: 5315 QRLVAATFAEVVGIPPERVGAESDFFDLGGNSLLATKLAARLGAARGVRVPVAAVFEAPT 5374 Query: 1617 IAELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAP 1653 + LA +DA +G A PP T + LAP Sbjct: 5375 VEALARRLDALDG-----AARPPLVRRTGTAPVPLAP 5406 Score = 43.9 bits (102), Expect = 0.20 Identities = 32/87 (36%), Positives = 49/87 (56%), Gaps = 5/87 (5%) Query: 1560 ERRLTAMLEELLEITG--IDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMT 1616 E + + E+L +T + D+++FALGG S++A K +A+ G AL +FE Sbjct: 4229 EEIVAGVYAEVLGLTDQRVGADDDFFALGGSSLLAAKAAARIGTALDRQVSVRTLFEAPR 4288 Query: 1617 IAELAAAVDAANG--EPVVEADPPPAQ 1641 +AELAAAV+AA P + A PA+ Sbjct: 4289 VAELAAAVEAAAAATRPPLVAGARPAR 4315 Score = 43.5 bits (101), Expect = 0.26 Identities = 30/94 (31%), Positives = 51/94 (54%), Gaps = 6/94 (6%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 +R++ A+ +LL + D+++FALGG+S+ A + A+ G AL P +F+ T+ Sbjct: 3156 QRQVAAVFADLLGAERVGLDDDFFALGGNSLTATRVVARLGAALDAQVPVRALFDAPTVE 3215 Query: 1619 ELAAAVD---AANGEPVVEADPPPAQEYTPMSAS 1649 LAA V + P + A P P + P+SA+ Sbjct: 3216 GLAARVAPLCGSGARPALTARPRP--DRIPLSAA 3247 Score = 39.3 bits (90), Expect = 4.9 Identities = 22/71 (30%), Positives = 40/71 (56%), Gaps = 1/71 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTIA 1618 ER + + E+L + RD+++FALGG+S++A + +A+ A L +F T+ Sbjct: 1041 ERAVARVFGEVLGRERVGRDDDFFALGGNSLVATQVAARLSADLNCSLGVREMFTATTVR 1100 Query: 1619 ELAAAVDAANG 1629 +LA ++ A G Sbjct: 1101 DLAELIERAGG 1111 >tr|A3KFG5|A3KFG5_9ACTO Tax_Id=196914 (pstC)SubName: Full=PstC protein;[Actinoplanes friuliensis] Length = 6661 Score = 819 bits (2116), Expect = 0.0 Identities = 561/1498 (37%), Positives = 763/1498 (50%), Gaps = 91/1498 (6%) Query: 26 AAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAV 85 AA ++ P P +R LS GQRR+WFL + T ++ VA RL G +D D + A+ Sbjct: 3073 AAARTRITPAARP-DRVPLSYGQRRLWFLHQFEASGATYHLPVALRLHGALDVDAMTAAL 3131 Query: 86 NDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLP--EAGHERQIESLAADE 143 DV RH LRT +G D +G V + D R L L EAG + +++ LA E Sbjct: 3132 GDVTDRHESLRTVFGEDADGSYQTVLAPDQA----RPALPVLDVAEAGLDHELD-LAVQE 3186 Query: 144 FGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-------- 195 FDL + PLR + R D+ VLL+VVHHI D S +L++AY Sbjct: 3187 ---AFDLRTQAPLRARLFRLGTDDHVLLVVVHHIAGDAWSMGPLARDLASAYAARVAGAA 3243 Query: 196 ---NDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXG--VSGANPCR 250 + LP+ +VL S A +W + L G Sbjct: 3244 PSWSPLPVQYADYSLWQHDVLDESEL--TARWIFWRQALAELPQELDLPADRSRGTRAAH 3301 Query: 251 RAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSG 310 R LPA L +R+ A + ++ FMVL AA L+ + +D + P+ R+ Sbjct: 3302 AGGRVPFELPADLSARLTAVAGETRSTLFMVLQAALATLLSKLGAGTDIPIGTPIAGRTD 3361 Query: 311 AAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM 369 A L G+F NTL+LR T TF + VRE LA +AHQ + +R+V E NPER Sbjct: 3362 DALDDLVGFFVNTLVLRTDTSGDPTFAELIARVREADLAAYAHQDLPFERLVEELNPERS 3421 Query: 370 GRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEY 429 V L N + AL G+ V G AA LS + ++ +Y Sbjct: 3422 LARHPLFQVLLTVNNTEQVEAPALPGLTVTSRAAGTGAAKFDLSFRLTEHDGSLNGALDY 3481 Query: 430 QQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPAT 488 + L + Q++ +++L+D A+P PL ++ LGA E+ VL + + P Sbjct: 3482 RTDLFDASTAAQLVERFVRLLDTVTADPAVPLRTVSGLGADEKHRVLHEWNN--TARPTR 3539 Query: 489 TMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMA 548 + D LTY+EL RR+N++ARW +G+G GPE +G+ + Sbjct: 3540 PVTLPELFTEQAARTPDAIAVECDGTTLTYAELDRRSNQVARWLVGRGAGPERFVGVVLP 3599 Query: 549 NSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNS 608 S + +V +L V K+GAAY+P+DPAYP ERI Y++ DARP VI DV A A Sbjct: 3600 RSTDLVVTLLGVAKSGAAYVPVDPAYPAERIGYILDDARPVLVID----DVRALAEAGTY 3655 Query: 609 DLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHV-QGFVAEWTMTAEDR 667 D + + P H YVIYTSGSTGRPKGV V H ++ ++ +G E A Sbjct: 3656 D-----TTAVNHAVPAHPVYVIYTSGSTGRPKGVVVQHSSVGAYLLRG--REVYPDAAGV 3708 Query: 668 WLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXX 727 L SSVSFD ++ ++ L G ++++ DL Sbjct: 3709 ALLHSSVSFDLTVTALYTPLVSGGRVVL------------GDLTETTTTRPTFMKVTPSH 3756 Query: 728 XXXXXXXXXQWRQLRHVPVGGEALPGEVADRF-AGYFDAELRNHYGPTEAVV-CSTHMVV 785 + GGEAL GEV + + A + D L N YGPTEA V C+ H V Sbjct: 3757 LALLEALPAHVSPSGTLVTGGEALTGEVINSWRAAHPDVALVNAYGPTEATVNCTDHHVA 3816 Query: 786 TGSH-GARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQR 844 G GA VPIG P N AYVLD L PV V GELY+ G LARGY RP LTA+R Sbjct: 3817 PGEPLGAGPVPIGRPFWNTQAYVLDAALQPVSAGVTGELYVAGVVLARGYWQRPGLTAER 3876 Query: 845 FIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAV 903 F+A+PF PG RLYRTGDLVR N G L ++GRAD QVK+RGFRIELGE+E+V+TT PAV Sbjct: 3877 FVANPFGAPGTRLYRTGDLVRWNADGTLVYLGRADGQVKLRGFRIELGEIEAVLTTDPAV 3936 Query: 904 RHCLVVAEETEAGPM-LAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTV 962 VV E + G L AY+ + ++ +R A A+P+YMVP AF + E P+T Sbjct: 3937 TQAAVVVREDQPGDKRLVAYV-----RGSVDGLRERVAQALPDYMVPSAFVALDEFPLTP 3991 Query: 963 SGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLA 1022 +GKLDRRALPAP R P E +C +FA+ G G +D+FF LGGHSLLA Sbjct: 3992 NGKLDRRALPAPDYGTAPTGRAPRNPREEVLCGLFAETLGLPAAGIDDNFFTLGGHSLLA 4051 Query: 1023 ARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRA 1082 RL+++IR+ V++ VR +F+ PT AGLAA L D +AA Sbjct: 4052 TRLISRIRSVLAVEVGVRQLFETPTVAGLAAAL----------DGGTVAA---------- 4091 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 R V RP+R+PLS++Q WF ++ EG + P+ALR G Sbjct: 4092 RTPVVARVRPERIPLSYAQQRLWFLHQFEGPSATYLQPMALRLSGDLDPALLRAALGDVI 4151 Query: 1143 XRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLR---RHVFTPESGP 1199 RHE+LRT F E PYQ+V L V I+ E + V+ QLR R F + Sbjct: 4152 ERHESLRTVFGEDASGPYQVVLDRAEAPLTV--IESSE-NAVAEQLRAESRRGFDLRADL 4208 Query: 1200 LLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFA 1259 ++A L VLG VLL++ HHIVSD S + DL+ AY AR AP W LP+Q+A Sbjct: 4209 PVRATLFVLGQRDFVLLILTHHIVSDAWSRGPLARDLVTAYAARAASEAPSWSPLPVQYA 4268 Query: 1260 DYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 DY++WQR + +L +W+ AL GLPD++ + TDR RP V RGE + F VPA Sbjct: 4269 DYSLWQREILGDDELDRQLGHWKQALDGLPDQLELPTDRPRPAVASYRGERLDFEVPADV 4328 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 + LT LA ++G + FM+ QAALA +L +LG GTD+ +G+P+A R + A L+G+F N Sbjct: 4329 QEQLTTLARQSGTSPFMVLQAALATLLTRLGAGTDVPIGTPIAGRTDEAVEDLIGVFINT 4388 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 +VLRTD SG+PT +L R+ L A AHQ+LP ERLVE LNP R+L+R+PLFQ +L Sbjct: 4389 LVLRTDTSGNPTFTDLLARVREADLVAYAHQDLPFERLVEELNPQRSLARHPLFQVLLTL 4448 Query: 1440 RGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 D V LT TV + L+ + P G + + + DLY+ Sbjct: 4449 NNTDLGAVDDALTRLPGLTVTRAGTDTGTGKFDLSFAFADRPGGLAGI-LEFSTDLYD 4505 Score = 787 bits (2032), Expect = 0.0 Identities = 552/1470 (37%), Positives = 741/1470 (50%), Gaps = 99/1470 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER +S Q+R+WFL + N VA RL G +D + TA+ DVVARH LRT + Sbjct: 1042 ERVPVSFAQQRLWFLHQFEGPSAAYNSPVALRLTGELDAAAMRTALADVVARHESLRTIF 1101 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLP--EAGHERQIESLAADEFGRPFDLTNELPLR 157 D G P Q+ V LP E LAA R FDL +E+P+R Sbjct: 1102 AEDGAG-PVQIVLPPAPV--------ELPVVRTDEESLAGELAAASRHR-FDLASEIPVR 1151 Query: 158 ITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQ 206 + E VLLL+ HHI D S +L+ AY LP+ Sbjct: 1152 AVLFALGEGEHVLLLLTHHIVSDAWSRAPLARDLATAYAARAAGNQPSWPPLPVQYADYS 1211 Query: 207 FLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLPAGLF 264 EVL + D +W + L + A+P R R + L Sbjct: 1212 LWQREVLGEAELGRQLD--FWKQALAGVPEELDLPADRIRPASPSHRGGRIEFTVDPELH 1269 Query: 265 SRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTL 323 R+ AR AS FMVL AA L+ R D + P+ R+ A L G+F NTL Sbjct: 1270 GRLTALARDHRASLFMVLQAALATLLTRLGAGDDIPIGTPIAGRTDDALDDLVGFFVNTL 1329 Query: 324 LLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGF 382 +LR T TF + VRE LA +AHQ + +R+V E NPER + R L + Sbjct: 1330 VLRTDTSGDPTFAELIARVREADLAAYAHQDLPFERLVEELNPERSLARHP---LFQTML 1386 Query: 383 NMRKSAGGLALD------GVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSV 436 N+ + ALD G+ R+ L L+ + A D ++ +Y L Sbjct: 1387 NLNNARLDEALDAIDHFAGLTARREDADTGQVKLDLAFSFAED-HGLAGALDYSTDLFDH 1445 Query: 437 LVDQMLVHYLQ-LVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 Q LV LQ +++ A+ + + +LGA E D VL + + P+ + Sbjct: 1446 ASAQALVERLQRILETVAADASVRIGDVPVLGADEADRVLREWNA--TARPSRAVSLTDL 1503 Query: 496 XXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIV 555 D L+Y+EL RR+N++ARW IGQG GPE +G+ + S E IV Sbjct: 1504 FAEQVARTPDAVAVECDGRTLSYAELDRRSNQVARWLIGQGAGPERFVGVVLPRSPELIV 1563 Query: 556 AMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAE-RAAADNSDLPLSD 614 +L V K+GAAY+P+DPAYP ERI Y++ DARP VI D A AA D+ + P++ Sbjct: 1564 TLLGVAKSGAAYVPVDPAYPAERIAYILEDARPVLVID----DAAVLTAAGDHDEAPVNQ 1619 Query: 615 SDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHV-QGFVAEWTMTAEDRWLQFSS 673 + P H YVIYTSGSTGRPKGV V H ++ ++ +G E A L SS Sbjct: 1620 AG------PAHPVYVIYTSGSTGRPKGVVVQHSSVGAYLLRG--REVYPDAAGSALVHSS 1671 Query: 674 VSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXX 733 VSFD ++ ++ L G ++++ GD+ A + VT Sbjct: 1672 VSFDLTVTALYTPLVSGGRIVL------GDLDEKAPPTTFMKVTPSHLALLEALPGEVSP 1725 Query: 734 XXXQWRQLRHVPVGGEALPGEVADRFAG-YFDAELRNHYGPTEAVV-CSTHMVVTGSH-G 790 + GGEAL GEV + + D L N YGPTEA V C+ + G G Sbjct: 1726 SGT-------LVTGGEALTGEVISSWRDTHPDVALVNAYGPTEATVNCTDFTMAPGFRPG 1778 Query: 791 ARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF 850 VPIG P N AYVLDE+L PVP V GELY+ G LARGY RP LTA+RF+A+PF Sbjct: 1779 PGPVPIGRPFWNTQAYVLDERLRPVPPGVTGELYVAGVVLARGYWQRPGLTAERFVANPF 1838 Query: 851 NP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVV 909 G RLYRTGD R N G L + GRAD QVK+RGFRIELGE+E+V+TT PAV V+ Sbjct: 1839 GAAGTRLYRTGDRARWNADGNLVYAGRADAQVKVRGFRIELGEIEAVLTTDPAVTQAAVL 1898 Query: 910 AEETEAGPM-LAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDR 968 E + G L AY+ + ++ +R A A+P+YMVP AF + E P+T +GKLDR Sbjct: 1899 VREDQPGDKRLVAYV-----RGSVDGLRERVAQALPDYMVPAAFVALDEFPLTPNGKLDR 1953 Query: 969 RALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQ 1028 RALPAP T R P E +C +FA++ G + G +++FF LGGHSLLA RL A+ Sbjct: 1954 RALPAPEYGPTTAGRAPRNPREELLCGLFAEVLGLESAGIDNNFFALGGHSLLATRLAAR 2013 Query: 1029 IRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVK 1088 +R+ VD+TVR +F+ PT AGLAA L D P RAR V Sbjct: 2014 VRSVLDVDVTVRQLFETPTVAGLAAAL----------DAGR---------PARARITAVV 2054 Query: 1089 SARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEAL 1148 RP+RLP+S +Q WF ++ EG +N P+ALR G RHE+L Sbjct: 2055 P-RPERLPVSFAQQRLWFLHQFEGPGAAYNSPVALRLTGVLDVPAMEAALNDVIARHESL 2113 Query: 1149 RTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVL 1208 RT F E P Q+V P+ L V D RH F + ++A + L Sbjct: 2114 RTVFTEDSHGPVQVVLPAARAALPVVTTDAASLPADLAAAVRHRFDLSTEIPVRAQVFSL 2173 Query: 1209 GPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNT 1268 G +VLL++ HHIVSD S + DL+ AY AR+ + P W LP+Q+ADY++WQR Sbjct: 2174 GERENVLLVLTHHIVSDAWSRVPLARDLVTAYAARVSGDEPSWSPLPVQYADYSLWQREI 2233 Query: 1269 FESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAE 1328 + +L +W+ L GLPD++ + TDR+RP V RGE + F VPA + +A Sbjct: 2234 LGDDELDRQLGHWKQTLDGLPDQLELPTDRSRPAVASYRGERLDFDVPADLYEQVKAVAR 2293 Query: 1329 RNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSG 1388 R+GA+ FM+ QAALA +L +LG GTDI +G+P+A R + A LVG+F N +VLRTD SG Sbjct: 2294 RSGASPFMVLQAALAALLTRLGAGTDIPIGTPIAGRTDEAVDDLVGVFINTLVLRTDTSG 2353 Query: 1389 DPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVP 1448 +P +L R+T L A AHQ+LP ERLVE LNP R+L+R+PLFQ +L D Sbjct: 2354 NPGFTELLARVRETDLAAYAHQDLPFERLVEELNPQRSLARHPLFQVLLTLDNTDHQGAL 2413 Query: 1449 RDLTGRGETTVVPLPVNFEVALLFLAIGMS 1478 L G T ++ VA LA G S Sbjct: 2414 DSLAGLPGLTAAEQVLDSAVAKFDLAFGFS 2443 Score = 756 bits (1952), Expect = 0.0 Identities = 528/1461 (36%), Positives = 721/1461 (49%), Gaps = 80/1461 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+R+WFL + T +A RL+G +D L A+ DV+ RH LRT + Sbjct: 4102 ERIPLSYAQQRLWFLHQFEGPSATYLQPMALRLSGDLDPALLRAALGDVIERHESLRTVF 4161 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 G D G PYQV D R E + E+ E L A E R FDL +LP+R T Sbjct: 4162 GEDASG-PYQVVLD------RAEAPLTVIESSENAVAEQLRA-ESRRGFDLRADLPVRAT 4213 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFL 208 + + VLL++ HHI D S +L AY + LP+ Sbjct: 4214 LFVLGQRDFVLLILTHHIVSDAWSRGPLARDLVTAYAARAASEAPSWSPLPVQYADYSLW 4273 Query: 209 SVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLPAGLFSR 266 E+L + +G+W + L A R +R +PA + + Sbjct: 4274 QREILGDDELDR--QLGHWKQALDGLPDQLELPTDRPRPAVASYRGERLDFEVPADVQEQ 4331 Query: 267 VEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLL 325 + AR+ SPFMVL AA L+ R +D + P+ R+ A L G F NTL+L Sbjct: 4332 LTTLARQSGTSPFMVLQAALATLLTRLGAGTDVPIGTPIAGRTDEAVEDLIGVFINTLVL 4391 Query: 326 RITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMR 385 R T TFT + VRE L +AHQ + +R+V E NP+R V L N Sbjct: 4392 RTDTSGNPTFTDLLARVREADLVAYAHQDLPFERLVEELNPQRSLARHPLFQVLLTLN-N 4450 Query: 386 KSAGGL-----ALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQ 440 G + L G+ V + G LS A P ++ E+ L Sbjct: 4451 TDLGAVDDALTRLPGLTVTRAGTDTGTGKFDLSFAFADRPGGLAGILEFSTDLYDRGTAG 4510 Query: 441 MLVHYLQLV-DKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXX 499 +L+ Q V +A+ P P+ +DILG +R +L + P ++V+ Sbjct: 4511 LLIERFQRVLREAVQAPGAPIGEIDILGPADRARLLLDWNTTARPTPDLSLVELLAEQVA 4570 Query: 500 XXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLA 559 D LTY+EL RA RLA W + QG GPE + + + S++ +V +LA Sbjct: 4571 RTPDAIAVEC--DGVHLTYAELDDRAARLASWLVDQGVGPERFVAVALPRSLDLLVTLLA 4628 Query: 560 VLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAAD-NSDLPLSDSDRL 618 V KAGA YLP+D YP +R+ Y++ DA+P V+G D + LPL+ + + Sbjct: 4629 VAKAGAGYLPLDLEYPADRLAYMLQDAQPVLVLGSGLPGATPIDDIDLTTQLPLTTT--V 4686 Query: 619 RPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDA 678 LR +YVIYTSGSTGRPKGV V A V + +TA DR L ++V FD Sbjct: 4687 EGLRD-RASYVIYTSGSTGRPKGVVVPDAAFVNFVIDMRDRFGLTAGDRLLAVTTVGFDI 4745 Query: 679 SLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQW 738 + ++FV L GA +++ D D + ++ LI G++V Sbjct: 4746 AGLELFVPLLAGATVVIAPRDVVRDAAALSALIGSAGISVMQATPSLWRAVLAEDTDLS- 4804 Query: 739 RQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGV 798 HV VGGEALP ++A R A + N YGPTE V ST V IG Sbjct: 4805 --ALHVLVGGEALPSDLA-RDLHTRAASVTNLYGPTETTVWSTVADVDPDRST----IGS 4857 Query: 799 PNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLY 857 P N YVLD L PVP V GE+Y+ G + RGY RP LTAQRF+A+P+ G R Y Sbjct: 4858 PIANTQVYVLDAALRPVPAGVAGEVYIAGDGVVRGYWQRPGLTAQRFVANPYGTTGSRFY 4917 Query: 858 RTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGP 917 RTGD+ R G LE++ RAD+QVK+RG RIELGE+E+V+ AV V+ E G Sbjct: 4918 RTGDIGRWAADGMLEYLSRADDQVKLRGHRIELGEIEAVLAADAAVAQAAVIVREDRPGD 4977 Query: 918 M-LAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTP 976 L AY+ +A + +R AAA+P YMVP AF + P+T +GKLDRRALPAP Sbjct: 4978 KRLVAYVRGSA-----DGLRDRAAAALPGYMVPAAFVELDTFPLTPNGKLDRRALPAPEY 5032 Query: 977 IATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVD 1036 R P E +C +FA++ G + VG +D FF LGGHSLLA RL+++IR+ G + Sbjct: 5033 DVEGTGRRPRNPREELLCGLFAEVLGVESVGIDDDFFALGGHSLLATRLISRIRSVLGAE 5092 Query: 1037 LTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLP 1096 + VR +F+APT A L A L D+ A P+ R RP R+P Sbjct: 5093 VAVRRLFEAPTVATLVATL------------DDGGAARTPVTAARERPA--------RVP 5132 Query: 1097 LSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRT---NFD 1153 +S +Q WF ++EG + +N+P+AL EG RHE+LRT D Sbjct: 5133 VSFAQQRLWFLRQLEGPSDAYNVPVALDLEGDLDVEALRGALADVVTRHESLRTVVVGSD 5192 Query: 1154 EHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTH 1213 E E + V L V D+ + D + +VF + +L+A LL PD Sbjct: 5193 EAEAYQVVLSPGQAAVTLTVEETDEADVDARVREAASYVFDISAETMLRAWLLTTAPDRE 5252 Query: 1214 VLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNW 1273 L+L+ HHI SD S I+ L+ AY AR+ P W LP+Q+ADY++WQR Sbjct: 5253 ELVLLTHHIASDAWSRTILVRYLVTAYVARVTGTEPAWPPLPVQYADYSLWQREVLGEAE 5312 Query: 1274 GQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGAT 1333 +LD+WR+ L GLP E+ + DR R G V F +PA A LT +A +T Sbjct: 5313 QTRQLDFWRNTLTGLPQELDLPVDRPRGSRPSYAGARVPFEIPAELSARLTAVAGETRST 5372 Query: 1334 EFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLR 1393 FM+ QAALA +L KLG GTDI +G+P+A R + A LVG F N +VLRTD SGDPT Sbjct: 5373 LFMVLQAALATLLSKLGAGTDIPIGTPIAGRTDDALDDLVGFFVNTLVLRTDTSGDPTFA 5432 Query: 1394 SILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPR---- 1449 ++ R+T L A AHQ+LP ERLVE LNP R+L+R+PLFQ MLN A V Sbjct: 5433 ELIARVRETDLAAYAHQDLPFERLVEELNPERSLARHPLFQTMLNLDNATPATVAELPGL 5492 Query: 1450 DLTGRGETTV-VPLPVNFEVA 1469 ++GR TV ++FE+A Sbjct: 5493 TVSGRPSGTVAAKFDLSFELA 5513 Score = 749 bits (1933), Expect = 0.0 Identities = 521/1466 (35%), Positives = 724/1466 (49%), Gaps = 96/1466 (6%) Query: 23 SGLAAEQSSDQPG-------ICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGL 75 +GLAA + +P + ER +S Q+R+WFL + N VA RL G+ Sbjct: 2034 AGLAAALDAGRPARARITAVVPRPERLPVSFAQQRLWFLHQFEGPGAAYNSPVALRLTGV 2093 Query: 76 VDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR--REDLTRLPEAGHE 133 +D + A+NDV+ARH LRT + D+ G P QV D LP Sbjct: 2094 LDVPAMEAALNDVIARHESLRTVFTEDSHG-PVQVVLPAARAALPVVTTDAASLPA---- 2148 Query: 134 RQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSA 193 LAA R FDL+ E+P+R V E VLL++ HHI D S +L Sbjct: 2149 ----DLAAAVRHR-FDLSTEIPVRAQVFSLGERENVLLVLTHHIVSDAWSRVPLARDLVT 2203 Query: 194 AY-----------NDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXG 242 AY + LP+ E+L + +G+W +TL Sbjct: 2204 AYAARVSGDEPSWSPLPVQYADYSLWQREILGDDELDR--QLGHWKQTLDGLPDQLELPT 2261 Query: 243 VSG--ANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFL 300 A R +R +PA L+ +V+ AR+ ASPFMVL AA L+ R +D Sbjct: 2262 DRSRPAVASYRGERLDFDVPADLYEQVKAVARRSGASPFMVLQAALAALLTRLGAGTDIP 2321 Query: 301 VSVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDR 359 + P+ R+ A L G F NTL+LR T FT + VRET LA +AHQ + +R Sbjct: 2322 IGTPIAGRTDEAVDDLVGVFINTLVLRTDTSGNPGFTELLARVRETDLAAYAHQDLPFER 2381 Query: 360 VVREANPERMGRDGMDLLVRLGFNMRKSAGGL----ALDGVVVRQLGLGAVAAHLPLSLT 415 +V E NP+R V L + G L L G+ + L + A L+ Sbjct: 2382 LVEELNPQRSLARHPLFQVLLTLDNTDHQGALDSLAGLPGLTAAEQVLDSAVAKFDLAFG 2441 Query: 416 IALDPDDVSV----EFE---YQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGA 468 + + EF + + + ++ D+ L+ ++ LA+P+ P+ + L Sbjct: 2442 FSDHRAGAGLRGVLEFSTDLFDRASAGLIADRFLL----VLRSVLADPQAPIGAAQTLDR 2497 Query: 469 GERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRL 528 E D +L + P ++V+ D A LTY+EL RA RL Sbjct: 2498 AESDRILTTWNDTTRPTPDLSLVELLAEQVTRTPEAIAVEC--DGARLTYAELDDRAARL 2555 Query: 529 ARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARP 588 A W + QG GPE + + + SI+ +V +LAV KAGA YLP+D YP +R+ Y++ DA+P Sbjct: 2556 ASWLVDQGVGPERFVAVALPRSIDLLVTLLAVAKAGAGYLPLDLEYPADRLAYMLQDAQP 2615 Query: 589 QTVIGRPELDVAERAAADNSDLPLSD--SDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSH 646 V+G + D+ DL + + + LR +YVIYTSGSTGRPKGV V Sbjct: 2616 VLVLGS---GLPGATPIDDIDLTMHQPLTTTVEGLRD-RASYVIYTSGSTGRPKGVVVPD 2671 Query: 647 HAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISY 706 A V + +TA DR L ++V FD + ++FV L GA +++ D D + Sbjct: 2672 AAFVNFVIDMRDRFGLTAGDRLLAVTTVGFDIAGLELFVPLLTGATVVIAPRDVVRDAAA 2731 Query: 707 VADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAE 766 ++ LI G++V HV VGGEALP ++A R A Sbjct: 2732 LSALIGSAGISVMQATPSLWRAVLAEDADLS---ALHVLVGGEALPSDLA-RDLHERAAS 2787 Query: 767 LRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLG 826 + N YGPTE V ST V IG P N YVLD L PVP V GE+Y+ Sbjct: 2788 VTNLYGPTETTVWSTVAEVEPGRST----IGTPIANTQVYVLDAALRPVPAGVPGEVYIA 2843 Query: 827 GSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRG 885 G + RGY RP LTAQRF+A+P+ G R YRTGD+ R G LE++ RAD+QVK+RG Sbjct: 2844 GDGVVRGYWQRPALTAQRFVANPYGTTGSRFYRTGDIGRWAADGTLEYLSRADDQVKLRG 2903 Query: 886 FRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQVDLEEIRAHTAAAVP 944 +RIELGE+E+V+ PAV V+ E G L AY+ +A + +R A ++P Sbjct: 2904 YRIELGEIEAVLAADPAVVQAAVLVREDRPGDKRLVAYVRGSA-----DGLRERIARSLP 2958 Query: 945 EYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQ 1004 EYMVP A + P+T +GKL+RRALPAP R+P E +C +FA++ G + Sbjct: 2959 EYMVPAAIVELDTFPLTPNGKLNRRALPAPDYGVESAGRQPRNPREELLCGLFAEVLGVE 3018 Query: 1005 RVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFE 1064 VG +D FF LGGHSLLA RL+++IR+ G ++ VR +F+ PT AGLAA Sbjct: 3019 SVGIDDDFFALGGHSLLATRLISRIRSVLGAEVAVRRLFETPTVAGLAATF--------- 3069 Query: 1065 LDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALR 1124 D AA AR +ARP R+PLS+ Q WF ++ E + +++P+ALR Sbjct: 3070 ---DTNAA---------ARTRITPAARPDRVPLSYGQRRLWFLHQFEASGATYHLPVALR 3117 Query: 1125 FEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDE--FD 1182 G RHE+LRT F E YQ V + A+ +D E D Sbjct: 3118 LHGALDVDAMTAALGDVTDRHESLRTVFGEDADGSYQTVLAPDQARPALPVLDVAEAGLD 3177 Query: 1183 DVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRA 1242 + F + L+A L LG D HVLL++VHHI D S+ + DL AY A Sbjct: 3178 HELDLAVQEAFDLRTQAPLRARLFRLGTDDHVLLVVVHHIAGDAWSMGPLARDLASAYAA 3237 Query: 1243 RLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPR 1302 R+ AP W LP+Q+ADY++WQ + + + +WR ALA LP E+ + DR+R Sbjct: 3238 RVAGAAPSWSPLPVQYADYSLWQHDVLDESELTARWIFWRQALAELPQELDLPADRSRGT 3297 Query: 1303 VLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVA 1362 G V F +PA A LT +A +T FM+ QAALA +L KLG GTDI +G+P+A Sbjct: 3298 RAAHAGGRVPFELPADLSARLTAVAGETRSTLFMVLQAALATLLSKLGAGTDIPIGTPIA 3357 Query: 1363 ARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALN 1422 R + A LVG F N +VLRTD SGDPT ++ R+ L A AHQ+LP ERLVE LN Sbjct: 3358 GRTDDALDDLVGFFVNTLVLRTDTSGDPTFAELIARVREADLAAYAHQDLPFERLVEELN 3417 Query: 1423 PPRALSRNPLFQNMLNFRGEDWALVP 1448 P R+L+R+PLFQ +L + P Sbjct: 3418 PERSLARHPLFQVLLTVNNTEQVEAP 3443 Score = 694 bits (1792), Expect = 0.0 Identities = 503/1427 (35%), Positives = 712/1427 (49%), Gaps = 93/1427 (6%) Query: 48 QRRMWFLQTMDPDDVTLNIC-VAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGE 106 Q F D DD+ + V++ + G +D L A + ++ RH LR + G+ Sbjct: 18 QEGFLFHSVYDGDDLDPYVVQVSFTIDGTLDAGVLRLAADALLRRHPNLRAAFRQRKSGD 77 Query: 107 PYQVFSDDVEVGWRREDLTRLPEAGHERQI-ESLAADEFGRPFDLTNELPLRITVIRTRA 165 Q+ DV W DL+ L A + + E LAAD R FD++ LR T++ A Sbjct: 78 WAQLVVRDVPTPWTDVDLSGLSGAAQDEAVAEVLAADRVKR-FDVSKPPLLRFTLVDLGA 136 Query: 166 DELVLLLVVHHICWDDDSWEVFFGELSAAY------NDLPINDPAAQFLSVEVLQNSAAP 219 +L HH+ D S V GEL A Y LP P +L+ +++ A Sbjct: 137 GRRRFVLTNHHLLLDGWSLPVLMGELLALYAARGDAGALPRVRPYRDYLTWLAARDNNAA 196 Query: 220 SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPF 279 A W L + A+ L A R+ AR+ + Sbjct: 197 REA----WRTALAGLEEPTLVHPGAARTAVTGAEVETL-LSAPETERLTAVARQHGVTLN 251 Query: 280 MVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA---LGYFGNTLLLRITTRSQDTFT 336 ++ AA+G+++ + TG D + V+ R G +G F NT+ RI +T Sbjct: 252 TMVQAAWGIVLGQLTGRDDVVFGSTVSCRPPELDGVETMVGLFINTVPTRIRLHPAETAG 311 Query: 337 SFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSA-GGLALDG 395 + + V+ A AH+ +G+ + RE+ + M V + + +A G L Sbjct: 312 ALLTRVQGELAARTAHEHLGLAEIRRESGHTELFDTSM---VFQNYPVVPAADAGSELGV 368 Query: 396 VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYL-QLVDKALA 454 + G A H PL L IA D V + Y+ L + + +V + +++ + A Sbjct: 369 GITVAAGNNREATHYPL-LLIAAARDTVQLRLSYRPDLYAEPAARRIVERVARVLAQFAA 427 Query: 455 EPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEA 514 +RP+ LD+L A E+ +VL + + ++P +++ + Sbjct: 428 GLDRPVGRLDLLTADEQRTVLREWNDTAHDVPDASLLDLFRAQVARTPDAAAVQ--AGPV 485 Query: 515 ELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAY 574 L+Y+EL R+ RLA +G GPE +G+ + + +V +LAVLK GAAYLPID ++ Sbjct: 486 VLSYAELDARSTRLAWALRERGAGPERFVGIALPRDAQLVVVLLAVLKTGAAYLPIDLSH 545 Query: 575 PDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRP----------LRPG 624 P +RI +++ D P ++ A AA ++ PL D L P +R G Sbjct: 546 PADRIAFMLADTEPALIV----TTAASAAALPPAEAPLLLVDDLEPAGAAAADLPPVRLG 601 Query: 625 HLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRW----LQFSSVSFDASL 680 H AYVIYTSGSTGRPKGV + H ++ ++Q W A L S +SFD ++ Sbjct: 602 HPAYVIYTSGSTGRPKGVVIEHRSLGAYLQ-----WARQAYPAMSGTSLLHSPISFDLTV 656 Query: 681 ADIFVTLFLGAQLIVPKPDAFGDISYVADLISRR---GVTVXXXXXXXXXXXXXXXXXXQ 737 ++ TL G + VADL R G Sbjct: 657 TALYTTLVAGG------------LVRVADLDERAAADGPRPTFLKGTPSVLAMLDALPDD 704 Query: 738 WRQLRHVPVGGEALPGEVADRFAG-YFDAELRNHYGPTEAVVCST-HMVVTGSHG-ARVV 794 + +GGE L GE ADR+ + A+L N YG TEA V S + + G+ A V Sbjct: 705 VSPSELIMLGGELLLGEAADRWRSRHPGADLLNVYGATEATVNSVQYRLAAGTPAPAGPV 764 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PG 853 P+G P N YVLD L PVP V GE Y+ G+ LARGY RP L+A+RF+A+PF+ PG Sbjct: 765 PVGRPFWNTRVYVLDAGLRPVPAGVPGEAYIAGTGLARGYWRRPGLSAERFVANPFDGPG 824 Query: 854 MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEET 913 R+YRTGD+VR N G+LEFVGR D QVK+RG+RIELGE+ESVI AV V+ E Sbjct: 825 ARMYRTGDVVRWNTDGQLEFVGRGDGQVKLRGYRIELGEIESVIAADDAVTQAAVLVRED 884 Query: 914 EAGPM-LAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALP 972 G L AY+ + + + +R A +P+YMVP AF V+ P+T +GKLDRRALP Sbjct: 885 RPGDKRLVAYV-----RGNADGLRERVAELLPDYMVPAAFVVLDVFPLTPNGKLDRRALP 939 Query: 973 APTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 AP R P E +C +FA++ G + G +D+FF LGGHSLLA RL+++IR+ Sbjct: 940 APAYDLEATLRAPRNPREEVLCGLFAEVLGLESAGIDDNFFALGGHSLLATRLISRIRSV 999 Query: 1033 FGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARP 1092 V++ VR +F+ PT AGLA D L A D D RAR V+ RP Sbjct: 1000 LDVEVGVRQLFETPTVAGLA---------------DALDAADP--DRVRARVVAVRP-RP 1041 Query: 1093 QRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF 1152 +R+P+S +Q WF ++ EG +N P+ALR G RHE+LRT F Sbjct: 1042 ERVPVSFAQQRLWFLHQFEGPSAAYNSPVALRLTGELDAAAMRTALADVVARHESLRTIF 1101 Query: 1153 DEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDT 1212 E P QIV P V+L V D++ RH F S ++A L LG Sbjct: 1102 AEDGAGPVQIVLPPAPVELPVVRTDEESLAGELAAASRHRFDLASEIPVRAVLFALGEGE 1161 Query: 1213 HVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-ES 1271 HVLLL+ HHIVSD S + DL AY AR N P W LP+Q+ADY++WQR E+ Sbjct: 1162 HVLLLLTHHIVSDAWSRAPLARDLATAYAARAAGNQPSWPPLPVQYADYSLWQREVLGEA 1221 Query: 1272 NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNG 1331 G+ +LD+W+ ALAG+P+E+ + DR RP RG ++F+V LT LA + Sbjct: 1222 ELGR-QLDFWKQALAGVPEELDLPADRIRPASPSHRGGRIEFTVDPELHGRLTALARDHR 1280 Query: 1332 ATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPT 1391 A+ FM+ QAALA +L +LG G DI +G+P+A R + A LVG F N +VLRTD SGDPT Sbjct: 1281 ASLFMVLQAALATLLTRLGAGDDIPIGTPIAGRTDDALDDLVGFFVNTLVLRTDTSGDPT 1340 Query: 1392 LRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLN 1438 ++ R+ L A AHQ+LP ERLVE LNP R+L+R+PLFQ MLN Sbjct: 1341 FAELIARVREADLAAYAHQDLPFERLVEELNPERSLARHPLFQTMLN 1387 Score = 492 bits (1267), Expect = e-136 Identities = 425/1399 (30%), Positives = 617/1399 (44%), Gaps = 108/1399 (7%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R +S Q+R+WFL+ ++ N+ VA L G +D + L A+ DVV RH LRT Sbjct: 5130 RVPVSFAQQRLWFLRQLEGPSDAYNVPVALDLEGDLDVEALRGALADVVTRHESLRTVVV 5189 Query: 101 VDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITV 160 E E YQV + +T E E +++ + FD++ E LR + Sbjct: 5190 GSDEAEAYQVVLSPGQAA-----VTLTVEETDEADVDARVREAASYVFDISAETMLRAWL 5244 Query: 161 IRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFLS 209 + T D L+L+ HHI D S + L AY LP+ Sbjct: 5245 LTTAPDREELVLLTHHIASDAWSRTILVRYLVTAYVARVTGTEPAWPPLPVQYADYSLWQ 5304 Query: 210 VEVLQNSAAPSVADVGYWAETLRXXXXXXXXX--GVSGANPCRRAQRRVRPLPAGLFSRV 267 EVL A + +W TL G+ P R +PA L +R+ Sbjct: 5305 REVL--GEAEQTRQLDFWRNTLTGLPQELDLPVDRPRGSRPSYAGARVPFEIPAELSARL 5362 Query: 268 EDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLLR 326 A + ++ FMVL AA L+ + +D + P+ R+ A L G+F NTL+LR Sbjct: 5363 TAVAGETRSTLFMVLQAALATLLSKLGAGTDIPIGTPIAGRTDDALDDLVGFFVNTLVLR 5422 Query: 327 ITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK 386 T TF + VRET LA +AHQ + +R+V E NPER L + Sbjct: 5423 TDTSGDPTFAELIARVRETDLAAYAHQDLPFERLVEELNPERSLARHPLFQTMLNLDNAT 5482 Query: 387 SAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDDVSVEFEYQQQL-SSVLVD 439 A L G+ V G VAA LS +A P + +Y L Sbjct: 5483 PATVAELPGLTVSGRPSGTVAAKFDLSFELAERGATADGPPVLGGWLDYSTDLFDETSAA 5542 Query: 440 QMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXX 499 ++ + +++ A+P R L S+D+L ER ++LA + + PA + + Sbjct: 5543 RLTARFTRILAAVAADPHRRLGSIDVLDPAERRTLLADRNDTAEDFPAVAVHELVARQAA 5602 Query: 500 XXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLA 559 + LTY+EL+ ANRLA I QG PED + + + E +V LA Sbjct: 5603 RTPDAVAV--TAGTTTLTYAELNAAANRLAHRLIRQGVRPEDRVAVLQERTAELVVTSLA 5660 Query: 560 VLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELD------VAERAAADNSDLPLS 613 VLKAG Y+P+DP P R ++++ D ++ D +A AAD+ D + Sbjct: 5661 VLKAGGVYVPLDPHQPAARSEFILRDTAAVALVTDRAPDALGFAALASVVAADSGDGTTA 5720 Query: 614 DSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSS 673 D D P P L YV+YTSGSTG PKGVA + HA H+ G W DR L S Sbjct: 5721 DPDV--PTAPDQLIYVMYTSGSTGTPKGVA-NTHANVVHLAG-ARYWRQGRHDRVLMHSP 5776 Query: 674 VSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXX 733 +FDAS +I+ L G +++V P G A +I+ + VT Sbjct: 5777 YAFDASTFEIWTPLLTGGRIVVAPPGRLGAPDLAA-VIAEQQVTGMFVSAGLFRVLADEH 5835 Query: 734 XXXQWRQLRHVPVGGEALPGEVADRFAGYFDAEL-RNHYGPTEAVVCSTHMVVTGSHGA- 791 + +R + GG+ + R + N YGPTE V ST + + Sbjct: 5836 PAC-FAGVREIWAGGDVVSPVAVRRVLDACPGTIVANEYGPTETTVFSTVNPLRAADTVP 5894 Query: 792 -RVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF 850 VVPIG P N YVLDE+L PV V GELYL G+ +ARGYLGRP LT QRF+ADPF Sbjct: 5895 EAVVPIGAPLWNTRVYVLDERLQPVAPGVKGELYLAGAGVARGYLGRPGLTGQRFVADPF 5954 Query: 851 -NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVV 909 G R+YRTGD+V + G L F GR D+QVK+RGFR+E GE+E+V+ P V V+ Sbjct: 5955 TGSGERMYRTGDVVSWDADGRLIFAGRVDDQVKLRGFRVEPGEIEAVLRQRPEVAEAAVI 6014 Query: 910 AEETEAG-PMLAAYLVPAAA-QVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLD 967 E G L AY+V AAA +++R H AA +P+Y+VP A ++ +P+T +GKLD Sbjct: 6015 LREDRPGDKRLVAYVVTAAAFSAHPDDLRRHVAATLPDYLVPSAVVLVDVLPLTANGKLD 6074 Query: 968 RRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVA 1027 R ALP P R P E+ + ++FA++ G VG ++ FF LGG S+++ +LV+ Sbjct: 6075 RAALPVP-EFGGSSGRGPRDEREKVLAALFAEVLGVAEVGVDEGFFDLGGDSIMSIQLVS 6133 Query: 1028 QIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFV 1087 + R G++L+VR +F+ T LA V R ++ A D+PL P + Sbjct: 6134 RAR-RAGLELSVREVFEHRTVEALAP--VVREVGAAPVEAPGEAYGDVPLTP------II 6184 Query: 1088 KSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEA 1147 +S + G ++FN ++ H+A Sbjct: 6185 QSFLDR-----------------GGPTDQFNQSRLVQVPASLTTERLAEALQAVLDHHDA 6227 Query: 1148 LRTNFDEHE-GVPYQIVHPSRTVQLAVRAID--QDEFDDVSTQLRRHVFTPESGPLLQAN 1204 LR +P +RT+ V + Q+ T+ R P +G +LQA Sbjct: 6228 LRAELHARRLTIPPPGATDARTLITRVETGEDGQEALLRTHTEAARQRLDPGAGTMLQAV 6287 Query: 1205 LLVLGPDT-HVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAV 1263 GP T +LLLIVHH+V D S ++ DL AY+A P+ + +A Sbjct: 6288 WFDRGPATPGLLLLIVHHLVVDGVSWRVLVPDLAEAYQAVSAGRPPRLQPVGTSLRGWAR 6347 Query: 1264 WQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKR---GEVVQF------- 1313 S E +W+ L+ R P +LGKR GE ++ Sbjct: 6348 QLTEVAASPVRAAEATWWQQVLS-----------RDTP-LLGKRPLDGERDRYDTAGHLT 6395 Query: 1314 -SVPAA-RRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPAT-- 1369 ++PAA LT + A + AA A+ + GG + L R E Sbjct: 6396 VTLPAAVTEQVLTTVPALFHAEVNDVLLAAFALAWARWRGGDGLLLDLEGHGREEHLVPG 6455 Query: 1370 ---AQLVGLFANVVVLRTD 1385 + +G F NV +R D Sbjct: 6456 ADLTRTIGWFTNVYPVRLD 6474 Score = 53.5 bits (127), Expect = 2e-04 Identities = 29/75 (38%), Positives = 41/75 (54%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 E E+ L A+ E+L + + DE +F LGGDSI++I+ ++A GL VFEH T+ Sbjct: 6094 EREKVLAALFAEVLGVAEVGVDEGFFDLGGDSIMSIQLVSRARRAGLELSVREVFEHRTV 6153 Query: 1618 AELAAAVDAANGEPV 1632 LA V PV Sbjct: 6154 EALAPVVREVGAAPV 6168 Score = 43.5 bits (101), Expect = 0.26 Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 1/89 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQA-GALGLPFPPAMVFEHMTIA 1618 E L + E+L + D N+FALGG S++A + +A+ L + +FE T+A Sbjct: 1975 EELLCGLFAEVLGLESAGIDNNFFALGGHSLLATRLAARVRSVLDVDVTVRQLFETPTVA 2034 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 LAAA+DA P E P+S Sbjct: 2035 GLAAALDAGRPARARITAVVPRPERLPVS 2063 Score = 40.8 bits (94), Expect = 1.7 Identities = 28/85 (32%), Positives = 42/85 (49%), Gaps = 3/85 (3%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L + E+L + + D+++FALGG S++A + S LG +FE T+A Sbjct: 5046 EELLCGLFAEVLGVESVGIDDDFFALGGHSLLATRLISRIRSVLGAEVAVRRLFEAPTVA 5105 Query: 1619 ELAAAVD--AANGEPVVEADPPPAQ 1641 L A +D A PV A PA+ Sbjct: 5106 TLVATLDDGGAARTPVTAARERPAR 5130 Score = 40.4 bits (93), Expect = 2.2 Identities = 26/74 (35%), Positives = 40/74 (54%), Gaps = 1/74 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L + E+L + D+N+FALGG S++A + S L + +FE T+A Sbjct: 957 EEVLCGLFAEVLGLESAGIDDNFFALGGHSLLATRLISRIRSVLDVEVGVRQLFETPTVA 1016 Query: 1619 ELAAAVDAANGEPV 1632 LA A+DAA+ + V Sbjct: 1017 GLADALDAADPDRV 1030 Score = 39.7 bits (91), Expect = 3.7 Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 2/89 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L + E+L + + D+++FALGG S++A + S LG +FE T+A Sbjct: 3004 EELLCGLFAEVLGVESVGIDDDFFALGGHSLLATRLISRIRSVLGAEVAVRRLFETPTVA 3063 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 LAA D N P + P+S Sbjct: 3064 GLAATFD-TNAAARTRITPAARPDRVPLS 3091 >tr|C1AR31|C1AR31_RHOOB Tax_Id=632772 SubName: Full=Putative non-ribosomal peptide synthetase;[Rhodococcus opacus] Length = 9855 Score = 805 bits (2080), Expect = 0.0 Identities = 560/1521 (36%), Positives = 756/1521 (49%), Gaps = 95/1521 (6%) Query: 34 PGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVA 90 P + P ER LS Q+R+WFL D N+ +A R +G +D L A+ V+ Sbjct: 2133 PALTPQERPEQVPLSPAQQRVWFLNQFDTSSPVYNLPLAVRFSGGLDVTALRRALRAVLH 2192 Query: 91 RHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFG---RP 147 RH LRT + ++ P+Q D+ +V DLT + E LAA G Sbjct: 2193 RHESLRTVFPA-SDSSPWQRILDEHDVDL---DLTVVEATDAE-----LAAAIRGFALAG 2243 Query: 148 FDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN----------- 196 FD+T E+P+R ++R R DE VL+LVVHHI D S+ +L AY Sbjct: 2244 FDVTTEIPVRARLLRVRNDEHVLVLVVHHIAADGWSFAPLSRDLMVAYAAHSGGRDLQWA 2303 Query: 197 DLPINDPAAQFLSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQ 253 LP+ E+L P + + YWA TL P ++ Sbjct: 2304 PLPVQYADYTLWQRELLGEKHDPDSRAARQLAYWATTLAGLPDSLDLP-TDRPRPSVASK 2362 Query: 254 RRVR---PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSG 310 + L R+ AR + FMV +A VL+ R + +D + PV R Sbjct: 2363 HGATVSWEISTELHERLLTLARTQDTTLFMVAHSALSVLLSRLSATTDIAIGTPVAGRGD 2422 Query: 311 AAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM 369 L G F NTL+LR +F + +VRE LA FAH V +R+V NP R Sbjct: 2423 RDLDDLVGMFVNTLVLRAQLDPASSFAELLQQVREVDLAAFAHTDVPFERLVEHLNPTRT 2482 Query: 370 GRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGL--GAVAAHLPLSLTIALD----PDDV 423 V L F A L L G+ V + A L L LT D P + Sbjct: 2483 AAHHPLFQVALFFQNHAPAH-LELPGLSVSSQPILPDVAAFDLQLVLTDTRDADGTPGPI 2541 Query: 424 SVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGEL 482 + EF Y +L + +++++D P P+ + I R L+ + Sbjct: 2542 TAEFNYATELFDESTIRSFGSQFVRILDAVTMAPHTPVGDIAIAHPAARIRELSGWNATD 2601 Query: 483 VEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDI 542 ++P TT+ V D A LTY E ANRLAR+ I G GPE Sbjct: 2602 HDVPDTTL--PDLFGAQAARTPDAPAVVFDGASLTYREFDEHANRLARYLISCGVGPESR 2659 Query: 543 IGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-------GRP 595 + L M S++ +V M AV+KAG AY+P+DP +P +RI Y++ A P V+ P Sbjct: 2660 VALAMRRSLDLVVGMYAVVKAGGAYVPVDPDHPADRIGYVLQSAGPVCVLTTTADRGALP 2719 Query: 596 ELDVAERAAADNSDL---PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEH 652 DV D SD P++D+DR+ PLR + AYVIYTSGSTG+PKGVAV H AI Sbjct: 2720 SGDVVTLDCLDLSDFSGAPVTDADRVYPLRADNTAYVIYTSGSTGKPKGVAVPHAAIVNQ 2779 Query: 653 VQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLIS 712 + +++ +T D LQ ++ +FD S+ F L +GA L++ PD D Y+A I Sbjct: 2780 LLWMQSQYALTGRDVVLQKTATTFDVSVWGFFWPLQVGAALVLAGPDGHRDPDYLARTID 2839 Query: 713 RRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYG 772 GVTV LRHV V GEALP E A RF A L N YG Sbjct: 2840 ELGVTVTDFVPSMLDVFVASVPADSCSSLRHVFVIGEALPPETASRFRDLSSAGLHNLYG 2899 Query: 773 PTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLAR 832 PTEA V T+ T VPIGVP N AYVLD +LHPV V GELYLGG QLAR Sbjct: 2900 PTEAAVSVTYWE-TSDADTVTVPIGVPEWNTQAYVLDSRLHPVAAGVPGELYLGGVQLAR 2958 Query: 833 GYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELG 891 GYLGR LT+ RF+A+PF G R+YRTGDLVRR G LE++GR D QVK RG RIELG Sbjct: 2959 GYLGRVDLTSDRFVANPFGGAGARMYRTGDLVRRRRDGVLEYIGRTDFQVKFRGQRIELG 3018 Query: 892 EVESVITTHPAVRHCLVVA-EETEAGPMLAAYLVPAAAQV-DLEEIRAHTAAAVPEYMVP 949 E+E+V+ +HP V VV + G L AY+VPA +V D EIR H + ++P YMVP Sbjct: 3019 EIETVLRSHPGVTGAAVVVYSDATTGDHLVAYVVPAPDRVADTAEIRRHASGSLPSYMVP 3078 Query: 950 GAFAVIPEIPMTVSGKLDRRALPAP--TPIATRRYREPETATERWICSIFAQLFGRQRVG 1007 A ++ E P+ SGKLDR+ALPAP T AT Y P T+ ER + S+F + G +RV Sbjct: 3079 SAVVLLDEFPLNTSGKLDRKALPAPEFTSDATE-YVAPSTSVERAVASVFCAVLGLERVS 3137 Query: 1008 AEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDL 1067 DSFF LGG+SL+A +LV+++R E V +TVR +F+ PT A LAARL + D Sbjct: 3138 VRDSFFELGGNSLIATQLVSRLRGELDVPVTVRDLFETPTVAELAARLSQSTGAD----- 3192 Query: 1068 DNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEG 1127 RP ++ RP+R+PLS +Q WF + + + +N+P A+RF G Sbjct: 3193 --------------TRPALIRRERPERIPLSPAQQRMWFLNQFDPSSPAYNLPFAVRFTG 3238 Query: 1128 PXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV--QLAVRAIDQDEFDDVS 1185 P RHE+LRT F + P+Q+V + L V I +DE + V Sbjct: 3239 PLDRVALEAAVADLVERHESLRTVFPDSATGPHQVVRDTADAPPNLTVADIAEDELETVL 3298 Query: 1186 TQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQ 1245 + F + ++ LL + HVL L+VHHI D S+ + D++VAY AR + Sbjct: 3299 ARFFTTGFDVTTDLPVRVTLLRVSAHEHVLALVVHHICGDGWSMAPMVRDVMVAYTARTR 3358 Query: 1246 HNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRAR 1300 P W LP+Q+ADYA+WQR +LDYW D LAG+PDE+ + TD R Sbjct: 3359 GERPAWTPLPVQYADYALWQRELLGDESDPDTLAARQLDYWTDTLAGIPDELELPTDHPR 3418 Query: 1301 PRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSP 1360 P RG V F + A+ AL LA+ AT FM+ ALAV+L +L +D+ +G+P Sbjct: 3419 PAEQSYRGSHVDFDIDASAHRALAALAQSRRATLFMVMHTALAVLLGRLSASSDVTIGTP 3478 Query: 1361 VAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEA 1420 VA R EP L+G+F N V LRT + +L RD L A + ++P ERLVE Sbjct: 3479 VAGRGEPELDDLIGMFVNTVALRTHVDPGSAFTDVLDHVRDVDLAAFSRADVPFERLVEV 3538 Query: 1421 LNPPRALSRNPLFQNMLNFRG-EDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSV 1479 L+P R +R+PLFQ ML F+ E AL LT RG T + + F+ L L + Sbjct: 3539 LSPTRHAARHPLFQVMLTFQNLEQTALELDGLTLRGLGTDIDV-AKFD---LHLTLVERF 3594 Query: 1480 TPSGELD---VQVIANADLYE 1497 P+G D Q+ DL++ Sbjct: 3595 DPAGRPDGMTAQLTYATDLFD 3615 Score = 779 bits (2012), Expect = 0.0 Identities = 529/1446 (36%), Positives = 721/1446 (49%), Gaps = 80/1446 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+RMWFL DP N+ A R G +D L AV D+V RH LRT + Sbjct: 3204 ERIPLSPAQQRMWFLNQFDPSSPAYNLPFAVRFTGPLDRVALEAAVADLVERHESLRTVF 3263 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 G P+QV D + +LT A E ++E++ A F FD+T +LP+R+T Sbjct: 3264 PDSATG-PHQVVRDTADAP---PNLTVADIA--EDELETVLARFFTTGFDVTTDLPVRVT 3317 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFL 208 ++R A E VL LVVHHIC D S ++ AY LP+ Sbjct: 3318 LLRVSAHEHVLALVVHHICGDGWSMAPMVRDVMVAYTARTRGERPAWTPLPVQYADYALW 3377 Query: 209 SVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAG 262 E+L + + P + + YW +TL P ++ R + A Sbjct: 3378 QRELLGDESDPDTLAARQLDYWTDTLAGIPDELELP-TDHPRPAEQSYRGSHVDFDIDAS 3436 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 + A+ A+ FMV+ A VL+ R + +SD + PV R L G F N Sbjct: 3437 AHRALAALAQSRRATLFMVMHTALAVLLGRLSASSDVTIGTPVAGRGEPELDDLIGMFVN 3496 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLG 381 T+ LR FT ++ VR+ LA F+ V +R+V +P R V L Sbjct: 3497 TVALRTHVDPGSAFTDVLDHVRDVDLAAFSRADVPFERLVEVLSPTRHAARHPLFQVMLT 3556 Query: 382 F-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTI------ALDPDDVSVEFEYQQQLS 434 F N+ ++A L LDG+ +R LG A L LT+ A PD ++ + Y L Sbjct: 3557 FQNLEQTA--LELDGLTLRGLGTDIDVAKFDLHLTLVERFDPAGRPDGMTAQLTYATDLF 3614 Query: 435 SV-LVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKX 493 D + + ++ + + + +LGA ER ++ + E +PATT+ Sbjct: 3615 DADTADSIAARFTTILGAVTTDATTRVGDIALLGADERAALTLWNSTEHA-VPATTL--P 3671 Query: 494 XXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEF 553 V D A LTY E ANRLAR+ + G GPE + L M S++ Sbjct: 3672 VLFDAQVARTPGAPALVLDGASLTYREFDEHANRLARYLVSCGVGPESRVALAMRRSLDL 3731 Query: 554 IVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-------GRPELDVAERAAAD 606 +V M AV+KAG AY+P+DP +P +RI Y++ A P V+ P DV D Sbjct: 3732 VVGMYAVVKAGGAYVPVDPDHPADRIGYVLQSAGPVCVLTTAADRGALPSGDVVTLDCLD 3791 Query: 607 NSDL---PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMT 663 SD P++D+DR+ PLR + AYVIYTSGSTG+PKGVAV H AI + +++ +T Sbjct: 3792 LSDFSGAPVTDADRVYPLRADNTAYVIYTSGSTGKPKGVAVPHAAIVNQLLWMQSQYALT 3851 Query: 664 AEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXX 723 D LQ ++ +FD S+ F L +GA L++ PD D Y+A I GVTV Sbjct: 3852 GRDVVLQKTATTFDVSVWGFFWPLQVGAALVLAGPDGHRDPDYLARTIDELGVTVTDFVP 3911 Query: 724 XXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHM 783 LRHV V GEALP E A RF A L N YGPTEA V T+ Sbjct: 3912 SMLDVFVASVPADSCSSLRHVFVIGEALPPETASRFRDLSSAGLHNLYGPTEAAVSVTYW 3971 Query: 784 VVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQ 843 T VPIGVP N AYVLD +LHPV V GELYLGG QLARGYLGR LT+ Sbjct: 3972 E-TSDADTVTVPIGVPEWNTQAYVLDSRLHPVAAGVPGELYLGGVQLARGYLGRVDLTSD 4030 Query: 844 RFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPA 902 RF+A+PF G R+YRTGDLVRR G LE++GR D QVK RG RIELGE+E+V+ +HP Sbjct: 4031 RFVANPFGGAGARMYRTGDLVRRRRDGVLEYIGRTDFQVKFRGQRIELGEIETVLRSHPG 4090 Query: 903 VRHCLVVA-EETEAGPMLAAYLVPAAAQV-DLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 V VV + G L AY+VPA +V D EIR H + ++P YMVP A ++ E P+ Sbjct: 4091 VTGAAVVVYSDATTGDHLVAYVVPAPDRVADTAEIRRHASGSLPSYMVPSAVVLLDEFPL 4150 Query: 961 TVSGKLDRRALPAPTPIA-TRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHS 1019 SGKLDR+ALPAP + Y P E+ + +FA + G RVG DSFF LGG+S Sbjct: 4151 NTSGKLDRKALPAPEFSSDATEYVAPRNEVEQALAGVFADVLGAGRVGVHDSFFDLGGNS 4210 Query: 1020 LLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDP 1079 L RL A+I G L+VR +F+APT A LA R+ D A D Sbjct: 4211 LSVTRLAARITETTGTRLSVRDVFEAPTVADLAVRI------------DPTARD------ 4252 Query: 1080 KRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 RP + RP R+PLS +Q W + + +N+P A+R G Sbjct: 4253 --VRPALTAAPRPARIPLSLAQQRMWLLNQFDADSPAYNLPFAVRLSGVVDTAALAAAFD 4310 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFD--DVSTQLRRHVFTPES 1197 RHE+LRT F + P Q+V V + + +D E D L F + Sbjct: 4311 DVVERHESLRTVFPDGGDGPEQVVLAVTDVSVTLPPVDVTEADLPGRMAALASRTFDVTA 4370 Query: 1198 GPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQ 1257 ++A L P HVL + +HHI +D S + D++VAY AR +APQW +Q Sbjct: 4371 ETPVRATLFRTAPTEHVLAISLHHIAADGWSFGPLGRDVMVAYAARTDGHAPQWAPFEVQ 4430 Query: 1258 FADYAVWQRNTFESNWGQ-----TELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQ 1312 +AD++VWQR+ S T+L +W LAG PDE+ + DR RP G V Sbjct: 4431 YADFSVWQRDVLGSEDDPESVLATQLGFWTRTLAGAPDELPLPFDRPRPAQPTFAGGSVG 4490 Query: 1313 FSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQL 1372 F + + LA +GAT FM+ A A+++ +L D+A+G+P+A R E A L Sbjct: 4491 FDIDPETHRRIRSLARDHGATTFMVAHTAFALLMARLSATDDVAIGTPIAGRGERALDDL 4550 Query: 1373 VGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPL 1432 VG+F N +VLRT ++G T +L RDT L A AH ++P ERLV+AL P R +R+P+ Sbjct: 4551 VGMFVNTLVLRTAVNGGATFAEMLRTVRDTDLAAFAHADVPFERLVDALAPTRTAARHPI 4610 Query: 1433 FQNMLN 1438 +Q L+ Sbjct: 4611 YQVALS 4616 Score = 768 bits (1983), Expect = 0.0 Identities = 532/1460 (36%), Positives = 725/1460 (49%), Gaps = 77/1460 (5%) Query: 26 AAEQSSDQPGICPGER---YRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLH 82 A QS +P + P ER LS Q+RMWFL D N+ +A RLAG +D + L Sbjct: 1069 AGPQSDPRPALEPRERPDRMPLSVAQQRMWFLNQFDTASAAYNLPIALRLAGALDREALR 1128 Query: 83 TAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAAD 142 A+ DV RH LRT + +G P+Q+ V V + L PE+ + A Sbjct: 1129 AALGDVQERHEALRTVFPDSADG-PHQLIKPAVSVLADTDPLDVDPES------LTAAVT 1181 Query: 143 EFGRP-FDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----N 196 G FDLT + PLR + R + VL+LVVHHI D S ++ AY Sbjct: 1182 ALGSTGFDLTADTPLRAGLFREAPERHVLVLVVHHIAADGWSMTPLAADVMVAYAARAAG 1241 Query: 197 DLPINDPA-AQFLSVEVLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGAN 247 PI P Q++ + Q S D + +W L Sbjct: 1242 HAPIWAPLPVQYVDYSLWQRDLLGSEDDPNSLSAKQIAHWRAALAGVPQLIELP-TDRTR 1300 Query: 248 PCRRAQRRVR---PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVP 304 P + R R +PA + R+ D A+ +PFMV AA VL+RR SD ++ P Sbjct: 1301 PAEMSHRGGRVEFTIPADVHGRLVDLAQSTGTTPFMVTHAALAVLLRRLGAGSDIVIGTP 1360 Query: 305 VTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVRE 363 V R A L G F NTL LR T DTF + R LA F H V +R+V Sbjct: 1361 VAGRGEEALDHLVGMFVNTLALRTTVDLGDTFEDVLARTRAADLAAFQHGDVPFERLVEV 1420 Query: 364 ANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDV 423 +P R V L F + + LDG+ V + A L LT+A + D Sbjct: 1421 LSPARSSAHHPLFQVMLTFQNTANTR-VELDGLEVEAAEIDVQVAKFDLHLTVAENVDAA 1479 Query: 424 SVEFEYQQQLSSV--LVDQMLV-----HYLQLVDKALAEPERPLSSLDILGAGERDSVLA 476 QLS L D V + +L+D P + LD+L + E + L Sbjct: 1480 GNAAGLAVQLSYATDLFDHSTVVSIGERFGRLLDAVSGNPPVAVGDLDLLDSREH-AALT 1538 Query: 477 QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQG 536 ++ +PA T+ V D+ LTY+E R +RLAR I G Sbjct: 1539 AANATHRPVPADTLASLFAAQAAATPDAVAL--VFDDRRLTYAEFDERTDRLARHLIRTG 1596 Query: 537 FGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPE 596 GPE ++ + M SI+ +VA+ A++KAGAAYLPIDP +P ER Y++ A+P V+ R Sbjct: 1597 VGPESVVAVGMRRSIDLLVAVYAIVKAGAAYLPIDPDHPAERTAYVLDTAQPVCVLTRAA 1656 Query: 597 LDVAERAAA-----DNSDLPLSDSDRLRP-LRPGHLAYVIYTSGSTGRPKGVAVSHHAIA 650 D R AA D DLP D + L G+ AYVI+TSGSTGRPKGVAV+H AI Sbjct: 1657 DDTTFRTAAPVVNIDTLDLPDQDPTPISTALTAGNTAYVIFTSGSTGRPKGVAVTHGAIV 1716 Query: 651 EHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADL 710 + E+ +T +D +Q + V+FD S+ ++F L +GA +++ PD D Y+A L Sbjct: 1717 NRLLWMQHEYGLTPDDAVMQKTPVTFDVSVWELFWPLQVGASMVIAAPDGHRDPDYLATL 1776 Query: 711 ISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNH 770 I R VT LR V GEAL E RF A L N Sbjct: 1777 IRRHRVTTMHFVPSMLSVFTAEPAVAVCDSLRLVFCSGEALTPEQVSRFRAVSGAGLHNL 1836 Query: 771 YGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQL 830 YGPTEA V T+ TG+ A VPIG P N +VLD +LHPVP+ V GE+YL G QL Sbjct: 1837 YGPTEAAVDVTYWE-TGAADALSVPIGRPVWNTQVHVLDARLHPVPNGVAGEVYLAGDQL 1895 Query: 831 ARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIEL 890 ARGYL R L++ RF+A+PF G R+YRTGDLVRR G LE++GR D QVK+RG RIEL Sbjct: 1896 ARGYLNRADLSSDRFVANPFVAGGRMYRTGDLVRRRGDGALEYLGRTDFQVKLRGQRIEL 1955 Query: 891 GEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVP 949 GE+ES + HP V +VV E G L AYLV A + ++RAH + VP YM+P Sbjct: 1956 GEIESALEAHPDVVQAVVVVHRDERGDEALVAYLVGRRA-AEWSDVRAHLSTRVPSYMIP 2014 Query: 950 GAFAVIPEIPMTVSGKLDRRALPAPT-PIATRRYREPETATERWICSIFAQLFGRQRVGA 1008 + +P++V+GKLDR+ALP PT AT Y P+T E + +FA++ G +RVG Sbjct: 2015 ARVVHLDTLPLSVNGKLDRKALPPPTLDTATAEYIAPQTPAEVVVAGVFAEILGVERVGT 2074 Query: 1009 EDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLD 1068 D FF LGG+SL+A RLV+++R GV +++R +FDAPT LA R LD Sbjct: 2075 HDHFFDLGGNSLVATRLVSRLRIALGVPVSLRDVFDAPTVGALAHR----------LDRV 2124 Query: 1069 NLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGP 1128 + AA P P RP+++PLS +Q WF + + + +N+PLA+RF G Sbjct: 2125 DPAAHPAP-------PALTPQERPEQVPLSPAQQRVWFLNQFDTSSPVYNLPLAVRFSGG 2177 Query: 1129 XXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL 1188 RHE+LRT F + P+Q + V L + ++ + +++ + Sbjct: 2178 LDVTALRRALRAVLHRHESLRTVFPASDSSPWQRILDEHDVDLDLTVVEATD-AELAAAI 2236 Query: 1189 RRHV---FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQ 1245 R F + ++A LL + D HVL+L+VHHI +D S + DL+VAY A Sbjct: 2237 RGFALAGFDVTTEIPVRARLLRVRNDEHVLVLVVHHIAADGWSFAPLSRDLMVAYAAHSG 2296 Query: 1246 HNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRAR 1300 QW LP+Q+ADY +WQR + +L YW LAGLPD + + TDR R Sbjct: 2297 GRDLQWAPLPVQYADYTLWQRELLGEKHDPDSRAARQLAYWATTLAGLPDSLDLPTDRPR 2356 Query: 1301 PRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSP 1360 P V K G V + + L LA T FM+ +AL+V+L +L TDIA+G+P Sbjct: 2357 PSVASKHGATVSWEISTELHERLLTLARTQDTTLFMVAHSALSVLLSRLSATTDIAIGTP 2416 Query: 1361 VAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEA 1420 VA R + LVG+F N +VLR L + +L R+ L A AH ++P ERLVE Sbjct: 2417 VAGRGDRDLDDLVGMFVNTLVLRAQLDPASSFAELLQQVREVDLAAFAHTDVPFERLVEH 2476 Query: 1421 LNPPRALSRNPLFQNMLNFR 1440 LNP R + +PLFQ L F+ Sbjct: 2477 LNPTRTAAHHPLFQVALFFQ 2496 Score = 764 bits (1972), Expect = 0.0 Identities = 526/1530 (34%), Positives = 758/1530 (49%), Gaps = 94/1530 (6%) Query: 26 AAEQSSDQPGICPGER---YRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLH 82 A++ ++++P + GER LS Q+RMWFL D I +A R++G +D L Sbjct: 5310 ASDTTAERPALVAGERPATIPLSPAQQRMWFLNQFDTTAAAYTIPLALRMSGRIDVATLR 5369 Query: 83 TAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAAD 142 TA+ DV+ARH LRT Y TE +QV V V DLT +G + L Sbjct: 5370 TALGDVLARHEALRTVYPA-TENGAHQVI---VPVESIPLDLTPTRLSGEDLSGAILRHA 5425 Query: 143 EFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY------- 195 G FD+T +LPLR+ + R E VLL VVHHI D S+ ++ +Y Sbjct: 5426 SAG--FDVTTDLPLRVHLFRESRSEHVLLFVVHHISADGWSFIPLASDVMTSYAARTAGD 5483 Query: 196 ----NDLPINDPAAQFLSVEVLQNSAAP---SVADVGYWAETLR--XXXXXXXXXGVSGA 246 N LP+ +L +S P + + + YW TL Sbjct: 5484 APVWNALPVQYADYAMWQRHLLGDSDDPQSLAASQIAYWKRTLAGLPDQVALPTDRPRPP 5543 Query: 247 NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVT 306 P L L ++ + AR AS FMV+ A L+ R D V V Sbjct: 5544 APSNLGGTARLTLDGDLHRQLHELARAHHASLFMVVHTALAALLSRLGAGPDVAVGTSVA 5603 Query: 307 ERSGAAA-GALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREAN 365 R + G +G F NTL+LR T + + +VR L F+H V +++V N Sbjct: 5604 GRGEQSLDGLVGMFVNTLVLRTDVHPDSTGAALLEQVRRVDLEAFSHVEVPFEQLVDAIN 5663 Query: 366 PERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------D 419 P R V L ++ L L G+ V L + + A L+ + + Sbjct: 5664 PTRSTAFHPLFQVALALQNLQTP-TLELPGLEVSALDIESPIAKFDLNFVLGERHDEDGN 5722 Query: 420 PDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQS 478 P + +E Y + L + ++ +++++ +P P+ LD+LG R +LAQS Sbjct: 5723 PAGLDLELGYAKDLFDADTASRIGESFVRVLSGLAHDPRTPVGDLDLLGDDARLRLLAQS 5782 Query: 479 HGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFG 538 HG E +T+V + LTY+E ANRLAR I G G Sbjct: 5783 HGATRETVHSTLVGLLDEQVRATPSAPAVRW--RDTALTYAEFDACANRLARKLIADGVG 5840 Query: 539 PEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL- 597 P+ ++ + + S++ +VA+ AV+KAG AY P+DP P++R ++ + V+ EL Sbjct: 5841 PDAVVAVEIPRSLDLLVAVHAVVKAGGAYTPLDPGQPEQRNRDIVEQSGASLVLTSSELL 5900 Query: 598 -----------DVAERA--AADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAV 644 +A A A+ P+ ++R+ PLRP + AYV++TSGSTGRPKGVAV Sbjct: 5901 RQTGATRHGVRAIAPDALDPAEFGGEPIRAAERIAPLRPDNTAYVLFTSGSTGRPKGVAV 5960 Query: 645 SHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDI 704 SH AI ++ ++ + D L + V+FD S+ + F L GA+L++ PD D Sbjct: 5961 SHAAITAQLEWLREQYALGTADTMLLKTPVTFDVSVWECFAPLAAGARLVIADPDGHRDP 6020 Query: 705 SYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFD 764 Y+A+++ GVTV LRHV VGGEA+ E D F Sbjct: 6021 EYLAEIVRTHGVTVVHFVPAMLAALTSGPGLTDMPALRHVLVGGEAVSPETIDDFRASHP 6080 Query: 765 AELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELY 824 AE+ N YGPTEA V +T S + VPIG+P N VLD++L PVP V GELY Sbjct: 6081 AEIDNTYGPTEAAVTTTFFAAR-SDNSDTVPIGLPVWNTSTLVLDDRLRPVPAGVAGELY 6139 Query: 825 LGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKI 883 LGG QLARGYLGRP LTA+RF+ADPF+ G RLYRTGDLVR G LE++GR D QVK+ Sbjct: 6140 LGGVQLARGYLGRPDLTAERFVADPFSTSGARLYRTGDLVRWTAAGRLEYLGRTDFQVKV 6199 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVA-EETEAGPMLAAYLVP-AAAQVDLEEIRAHTAA 941 RGFRIELGE+ S + H V +VV + G L Y+VP A +D + + A A Sbjct: 6200 RGFRIELGEIVSALLRHEDVDQAVVVPHSDPHTGEHLVGYVVPRGAVALDCDAVLAEAAG 6259 Query: 942 AVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLF 1001 ++P YMVP + E+P+T +GK+DR ALPAP Y P T +ER + ++FA+L Sbjct: 6260 SLPSYMVPSLLVPLTELPLTPNGKVDRNALPAPVFAGKAEYTAPRTESERVVAAVFAELL 6319 Query: 1002 GRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRN 1061 G RVG +D+FF LGG+SL A +L +I + +R +FDAPT A LA RL + Sbjct: 6320 GVSRVGVDDNFFELGGNSLSATKLSTRIGVATQTRIAIRDVFDAPTVAALARRLDQH--- 6376 Query: 1062 DFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPL 1121 P A + RP R+PLS +Q WF + E + +N+P Sbjct: 6377 ----------------GPSTAIAPLTAAVRPGRIPLSLAQQRMWFLNQFETSSPAYNLPA 6420 Query: 1122 ALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEF 1181 A+R G RHE+LRT F + G P+Q++ V + E Sbjct: 6421 AVRLTGSLDTAALAAAIGDLIARHESLRTVFPDSRGGPHQVILEPGDFTPDVAPVHVSET 6480 Query: 1182 D---DVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIV 1238 D+ L E+ P L+ + LGP HVL L+VHHI +D AS+E + D+++ Sbjct: 6481 GLRADLQEFLLAGFDVSEAVP-LRVKVYSLGPAEHVLALVVHHISADGASMEPLIRDVMI 6539 Query: 1239 AYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEIS 1293 AY +R + P W LP+Q+ADYA+WQR S + +LDYW ALAG+PD++ Sbjct: 6540 AYGSRAAGHPPTWAPLPVQYADYALWQRTVLGSESEPGSLAAAQLDYWTRALAGVPDQLY 6599 Query: 1294 VATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGT 1353 + DR RP V RG +F++ A ALT+LA +GA+ FM+ AAL+V+L +L Sbjct: 6600 LPGDRGRPAVPTHRGAATRFTLDAGTHRALTELARAHGASLFMVAHAALSVLLGRLSTTA 6659 Query: 1354 DIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELP 1413 DIA+G+ VA R ++G+F N +VLRT L + ++L +R L+A AH +LP Sbjct: 6660 DIAVGTAVAGRGRVELDDIIGMFVNTLVLRTTLDPGASFVALLAQTRTVDLEAFAHADLP 6719 Query: 1414 IERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFL 1473 ERLVE L+P R+ S +PLFQ L + V D +V PL ++ +A L Sbjct: 6720 FERLVEVLSPVRSTSHHPLFQVALGVQA-----VSADGLELDGLSVTPLTLDASIAKFDL 6774 Query: 1474 AIGM------SVTPSGELDVQVIANADLYE 1497 + + P+G +D ++I D+++ Sbjct: 6775 HFTLTERLDDTAEPAG-IDAELIYATDIFD 6803 Score = 761 bits (1964), Expect = 0.0 Identities = 518/1454 (35%), Positives = 734/1454 (50%), Gaps = 81/1454 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 E LS Q+RMWF+ D N+ VA RL+G VD + A+ D+V RH LRT Y Sbjct: 7450 EHIPLSLAQQRMWFINQFDTASPAYNLPVALRLSGEVDLRAMQIAIADLVGRHEALRTVY 7509 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G P+QV + +T P+ ER + + FD+T+++PLR Sbjct: 7510 PDSGDG-PHQVIVPAADAVPDLTPVTAHPDDVLERVLALVTTG-----FDVTSDVPLRAR 7563 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFL 208 + R AD+ VL++V HHI D S ++ AY LP+ Sbjct: 7564 MYRVGADDYVLVMVAHHISGDGWSLAPLARDVMLAYTARTEGHVPLWTPLPVQYADYSLW 7623 Query: 209 SVEVLQNSAAP-SVA--DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAG 262 E+L + A P SVA + YW TL P + R + A Sbjct: 7624 QRELLGDEADPESVAAEQIAYWTRTLDGLPDRLSLP-TDRPRPAVASHRGAHVPFTIDAA 7682 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 + AR + S FMV+ A VL+ R + SD V P+ R + L G F N Sbjct: 7683 THRALLTLARGRNTSLFMVMHTALAVLLARLSNESDIAVGAPIAGRGEESLDELVGMFVN 7742 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLG 381 TL+LR +F +N R T L+ FAH + +R+V NP R V Sbjct: 7743 TLVLRTHVDLASSFADSLNVARSTDLSAFAHSDIPFERLVDVLNPARSRSHHPLFQVAFS 7802 Query: 382 FNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVSVEFEYQQQL-S 434 F +A L L G+ V L + + L LT++ PD + +F Y L Sbjct: 7803 FQNLATAT-LELPGLHVEGLDVPNTISTFDLHLTLSEKHDADGTPDVIEAQFTYATDLFD 7861 Query: 435 SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 V + ++++ + +P+ + ++D+LG ER SV+A+ + V++P TT+ Sbjct: 7862 DTTVRAFAERFTRILESVVRDPDLAVGAIDLLGGAERQSVIAEFNDTAVDLPPTTLADLF 7921 Query: 495 XXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFI 554 + ELTYSE RR + LA I G GP+ ++GL M SIE + Sbjct: 7922 SAQAVRTPDYPAVFF--EGTELTYSEFDRRVDALAHRLIDSGVGPDTVVGLAMNRSIELL 7979 Query: 555 VAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR-PELDVAERAAA---DNSDL 610 M AVL+AG AYLPID +P +R+ Y++ ARP V+ P+ AE D DL Sbjct: 7980 AGMYAVLRAGGAYLPIDLGHPADRLAYVLETARPVCVLTTSPDGFTAENVPVIEIDTLDL 8039 Query: 611 ------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTA 664 P++D+ R PLRP + AY+I+TSGSTGRPKGVAVSH AIA ++ E+ + Sbjct: 8040 TGSPRGPVTDAHRRAPLRPENTAYLIFTSGSTGRPKGVAVSHAAIANQLRWKQHEYPLDT 8099 Query: 665 EDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXX 724 D +Q + V+FD S+ ++F L GA+L++ +PD D +Y+ADL+ ++ VT Sbjct: 8100 TDAVVQKTPVTFDLSVWELFWPLMSGARLVISRPDGHRDPAYLADLMRQQRVTTAHFVPS 8159 Query: 725 XXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYF-DAELRNHYGPTEAVVCSTHM 783 + LR V GEALP + A RF F L N YGPTEA V T Sbjct: 8160 LLEAFIPDAG--EQPTLRRVLCIGEALPVDTAARFRSRFASVALHNLYGPTEAAVSVTAW 8217 Query: 784 VVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQ 843 T VPIG P N A+VLD +L+PVP V GELYL G QLARGY+ R LTA+ Sbjct: 8218 THTDVD-TDTVPIGGPEWNTQAFVLDARLNPVPVGVAGELYLAGDQLARGYVARTDLTAE 8276 Query: 844 RFIADPFN-PGMRLYRTGDLVR---RNHCGELEFVGRADEQVKIRGFRIELGEVESVITT 899 RF+A+PF PG RLYRTGD+VR R G LE++ R+D QVK+RGFRIELGE+ES + Sbjct: 8277 RFVANPFGAPGARLYRTGDVVRWRIRGTTGVLEYLERSDFQVKVRGFRIELGEIESALIR 8336 Query: 900 HPAVRHCLVVAEET-EAGPMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPE 957 V +VVA G L AY+VP + VD + A AAVP YMVP A V+ E Sbjct: 8337 SAGVGQAVVVAHRNPHTGTALVAYVVPEDGSTVDPTAVLADVGAAVPSYMVPAALVVLAE 8396 Query: 958 IPMTVSGKLDRRALPAPT-PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLG 1016 +P+T +GKLDR+ALPAP A YR P T TE + +++A + G ++VG +FF LG Sbjct: 8397 LPLTANGKLDRKALPAPDFASAAAEYRAPATPTEEIVAAVYADVLGVEQVGTAANFFDLG 8456 Query: 1017 GHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMP 1076 G+SL+A R+VA++ G + +R++F+AP LAA L D + A Sbjct: 8457 GNSLVATRVVARLSETLGRRVEIRSLFEAPAVGALAALL----------DSTDATAP--- 8503 Query: 1077 LDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXX 1136 RP + RP+ LPLS +Q WF R + N+P+A+R G Sbjct: 8504 -----TRPALTPAVRPELLPLSSAQQRMWFLNRFDPDSAVHNIPVAVRLSGVLDVDALQH 8558 Query: 1137 XXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV--QLAVRAIDQDEFDDVSTQLRRHVFT 1194 RHE+LRT + + P+Q++ + V + +V A D+ + L F Sbjct: 8559 AVADVLHRHESLRTIYPDSADGPHQVILSTDRVGAETSVDAADEAALPALIADLVTTGFD 8618 Query: 1195 PESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDIL 1254 + ++ + + HVL ++VHHI D S+ + D++ AY AR +P W L Sbjct: 8619 VTAEVPVRVRIFRISATEHVLAVVVHHISGDGWSMAPMVRDVMAAYSARSAGTSPDWAPL 8678 Query: 1255 PIQFADYAVWQRN-----TFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGE 1309 P+Q+ADYA+WQR+ T + +L +W LAG PD++ + TDR RP V RG Sbjct: 8679 PVQYADYALWQRDLLGDETDPDSVAARQLAFWTQTLAGAPDQLDLPTDRPRPAVASYRGG 8738 Query: 1310 VVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPAT 1369 V F+VPA + A A+ FM+ +ALAV+L +L G DI++G+PVA R E Sbjct: 8739 TVDFTVPADLHGTVVGAARDANASVFMVVHSALAVLLSRLAGSGDISIGTPVAGRGEREL 8798 Query: 1370 AQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSR 1429 L+G+F N +VLR + G T +L R+T L A +H ++P ERLVE +NP R+ R Sbjct: 8799 DDLIGMFVNTLVLRQHVDGGRTFAELLADVRETDLAAFSHADVPFERLVEVVNPSRSTGR 8858 Query: 1430 NPLFQNMLNFRGED 1443 +PLFQ ML F+ D Sbjct: 8859 HPLFQVMLTFQNLD 8872 Score = 717 bits (1850), Expect = 0.0 Identities = 498/1459 (34%), Positives = 715/1459 (49%), Gaps = 101/1459 (6%) Query: 38 PGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRT 97 PG R LS Q+RMWFL + N+ A RL G +D L A+ D++ARH LRT Sbjct: 6391 PG-RIPLSLAQQRMWFLNQFETSSPAYNLPAAVRLTGSLDTAALAAAIGDLIARHESLRT 6449 Query: 98 TYGVDTEGEPYQVFSDDVEVGWRREDLT--RLPEAGHERQIESLAADEFGRPFDLTNELP 155 + D+ G P+QV +E G D+ + E G ++ FD++ +P Sbjct: 6450 VFP-DSRGGPHQVI---LEPGDFTPDVAPVHVSETGLRADLQEFLL----AGFDVSEAVP 6501 Query: 156 LRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-----------LPINDPA 204 LR+ V E VL LVVHHI D S E ++ AY LP+ Sbjct: 6502 LRVKVYSLGPAEHVLALVVHHISADGASMEPLIRDVMIAYGSRAAGHPPTWAPLPVQYAD 6561 Query: 205 AQFLSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSG--ANPCRRAQRRVRPL 259 VL + + P + A + YW L G G A P R L Sbjct: 6562 YALWQRTVLGSESEPGSLAAAQLDYWTRALAGVPDQLYLPGDRGRPAVPTHRGAATRFTL 6621 Query: 260 PAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG-ALGY 318 AG + + AR AS FMV AA VL+ R + +D V V R +G Sbjct: 6622 DAGTHRALTELARAHGASLFMVAHAALSVLLGRLSTTADIAVGTAVAGRGRVELDDIIGM 6681 Query: 319 FGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLV 378 F NTL+LR T +F + + + R L FAH + +R+V +P R V Sbjct: 6682 FVNTLVLRTTLDPGASFVALLAQTRTVDLEAFAHADLPFERLVEVLSPVRSTSHHPLFQV 6741 Query: 379 RLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL---SS 435 LG SA GL LDG+ V L L A A L T+ DD + +L + Sbjct: 6742 ALGVQA-VSADGLELDGLSVTPLTLDASIAKFDLHFTLTERLDDTAEPAGIDAELIYATD 6800 Query: 436 VLVDQMLVHYL----QLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMV 491 + + Y ++ + +A+P+RP+ + +LG E ++ + P + Sbjct: 6801 IFDESTAAGYATRLRRIFEAVVADPQRPIGDIPVLGEDEHAALTPVRGAD----PRPVQM 6856 Query: 492 KXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSI 551 V D A LTY +L R+N+LAR + +G GPE + L + S Sbjct: 6857 LPEILADAVAAAPDGLAVVFDGAGLTYRDLDERSNQLARLLVDRGVGPETSVALALPRSF 6916 Query: 552 EFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQT------------------VIG 593 E +VA+ AV K GAA++P+DP YP +RI +++ D+ ++ Sbjct: 6917 ESVVAVWAVAKTGAAFVPVDPGYPADRIVHMVQDSGAMVGITVSAKRALLPDSIRWMLLD 6976 Query: 594 RPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHV 653 P L+V S LPL++ DR+RP+ +AYVIYTSGSTGRPKGVAV+H + V Sbjct: 6977 DPALEVR---CTHESRLPLTNRDRMRPILSDQVAYVIYTSGSTGRPKGVAVTHRGLMNLV 7033 Query: 654 QGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISR 713 +T+ R L F+S SFDAS+ ++ + L GA +++ P +G S +A+L++ Sbjct: 7034 TDERELLAVTSRSRTLHFASPSFDASVFEMLMALGAGATMVIAPPTIYGG-SELAELLAA 7092 Query: 714 RGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGP 773 +T +L V V G+ P E+ R+A L N YGP Sbjct: 7093 ERITHAFSTPAALASVDHHGLD----ELAVVVVAGDVCPPELVARWAP--GRRLVNAYGP 7146 Query: 774 TEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARG 833 +EA + S+ + V IG P+R V A VLD +L PVP V GELY+GG LARG Sbjct: 7147 SEATIMSS--ITEPLRAGEPVTIGGPSRGVRALVLDGRLRPVPVGVPGELYVGGPSLARG 7204 Query: 834 YLGRPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGE 892 YLGRP LTA+RF+ADP+ PG +YRTGDLVR L+FVGR D QVKIRGFRIELGE Sbjct: 7205 YLGRPGLTAERFVADPYGEPGDLMYRTGDLVRWREDRVLDFVGRTDHQVKIRGFRIELGE 7264 Query: 893 VESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPG 950 +++ +T HP + + + E G L AY++P + VD E+ +P YMVP Sbjct: 7265 IDAALTAHPQIEYATTIGYEHPNGETSLVAYVLPFTGEDVDRVEVANFVGRTLPAYMVPA 7324 Query: 951 AFAVIPEIPMTVSGKLDRRALPAPT-PIATRRYREPETATERWICSIFAQLFGRQRVGAE 1009 + ++ +P+T +GKLDR ALP P A + P E + IFA + +G Sbjct: 7325 SVTLLDALPLTPAGKLDRSALPEPIFAAAATTFEAPRNPMEVIVAGIFADILALPEIGIH 7384 Query: 1010 DSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDN 1069 DSFF LGG+SLLA ++V++I A V + VR +F++PT A LAAR+ E + Sbjct: 7385 DSFFDLGGNSLLATQVVSRINAALDVHVGVREVFESPTVAALAARITETTTHG------- 7437 Query: 1070 LAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPX 1129 RP ARP+ +PLS +Q WF + + A +N+P+ALR G Sbjct: 7438 -----------ARRPALTARARPEHIPLSLAQQRMWFINQFDTASPAYNLPVALRLSGEV 7486 Query: 1130 XXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLR 1189 RHEALRT + + P+Q++ P+ + + DDV ++ Sbjct: 7487 DLRAMQIAIADLVGRHEALRTVYPDSGDGPHQVIVPAADAVPDLTPVTAHP-DDVLERVL 7545 Query: 1190 RHV---FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQH 1246 V F S L+A + +G D +VL+++ HHI D SL + D+++AY AR + Sbjct: 7546 ALVTTGFDVTSDVPLRARMYRVGADDYVLVMVAHHISGDGWSLAPLARDVMLAYTARTEG 7605 Query: 1247 NAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARP 1301 + P W LP+Q+ADY++WQR + ++ YW L GLPD +S+ TDR RP Sbjct: 7606 HVPLWTPLPVQYADYSLWQRELLGDEADPESVAAEQIAYWTRTLDGLPDRLSLPTDRPRP 7665 Query: 1302 RVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPV 1361 V RG V F++ AA AL LA + FM+ ALAV+L +L +DIA+G+P+ Sbjct: 7666 AVASHRGAHVPFTIDAATHRALLTLARGRNTSLFMVMHTALAVLLARLSNESDIAVGAPI 7725 Query: 1362 AARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEAL 1421 A R E + +LVG+F N +VLRT + + L +R T L A AH ++P ERLV+ L Sbjct: 7726 AGRGEESLDELVGMFVNTLVLRTHVDLASSFADSLNVARSTDLSAFAHSDIPFERLVDVL 7785 Query: 1422 NPPRALSRNPLFQNMLNFR 1440 NP R+ S +PLFQ +F+ Sbjct: 7786 NPARSRSHHPLFQVAFSFQ 7804 Score = 662 bits (1709), Expect = 0.0 Identities = 485/1459 (33%), Positives = 703/1459 (48%), Gaps = 113/1459 (7%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS Q+RMW L D D N+ A RL+G+VD L A +DVV RH LRT + Sbjct: 4265 RIPLSLAQQRMWLLNQFDADSPAYNLPFAVRLSGVVDTAALAAAFDDVVERHESLRTVFP 4324 Query: 101 VDTEGEPYQVFS-DDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G V + DV V D+T EA ++ +LA+ R FD+T E P+R T Sbjct: 4325 DGGDGPEQVVLAVTDVSVTLPPVDVT---EADLPGRMAALAS----RTFDVTAETPVRAT 4377 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDP-AAQFLSVEVL 213 + RT E VL + +HHI D S+ ++ AY P P Q+ V Sbjct: 4378 LFRTAPTEHVLAISLHHIAADGWSFGPLGRDVMVAYAARTDGHAPQWAPFEVQYADFSVW 4437 Query: 214 QNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAG--- 262 Q S D +G+W TL P R R +P AG Sbjct: 4438 QRDVLGSEDDPESVLATQLGFWTRTLAGAPDELPL-------PFDRP-RPAQPTFAGGSV 4489 Query: 263 -------LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA 315 R+ AR A+ FMV A+ +L+ R + D + P+ R A Sbjct: 4490 GFDIDPETHRRIRSLARDHGATTFMVAHTAFALLMARLSATDDVAIGTPIAGRGERALDD 4549 Query: 316 L-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 L G F NTL+LR TF + VR+T LA FAH V +R+V P R Sbjct: 4550 LVGMFVNTLVLRTAVNGGATFAEMLRTVRDTDLAAFAHADVPFERLVDALAPTRTAARHP 4609 Query: 375 DLLVRLGFNMRKSAGGLALDG--VVVRQLGLGAVAAHLPLSLTIALD----PDDVSVEFE 428 V L N +S L G + V + G L L+L LD P + EF Sbjct: 4610 IYQVALSMNPLQSPD-YELPGLRIGVEDVDPGVAKIDLQLTLGEELDHTGAPSGMRAEFI 4668 Query: 429 YQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVL-AQSHGELVEMP 486 Y L + + ++++ ++P+ + LD+L ERD+++ A L+ + Sbjct: 4669 YATDLFDESTISDVASRLQRILEAVTSDPDTLVGDLDLLHDAERDALVPASGRPGLIPVT 4728 Query: 487 ATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLR 546 ++ + + L+Y L +NRLAR I GPE + L Sbjct: 4729 LPDLLAGAVRSNPDGDALVAPGHGTSDGTLSYRALDATSNRLARLLIDLQVGPEVSVALA 4788 Query: 547 MANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL--------- 597 + S E +VA AV K+GAA++P+DP YP +RI +++ D I L Sbjct: 4789 LPRSRESVVATWAVTKSGAAFVPVDPNYPADRIAFMLEDCGAPIGITTAALRENLPDSTL 4848 Query: 598 ------DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAE 651 D A S P+ DSDR+ L H AY+IYTSGSTGRPKGVAVSH + Sbjct: 4849 WLVLDDDAVIEALTSYSSEPVQDSDRVAALSVDHPAYLIYTSGSTGRPKGVAVSHRGVVN 4908 Query: 652 HVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLI 711 + +E R L F+S SFDAS+ ++ + + GA L+V FG +A+ + Sbjct: 4909 LAADERVRLGVLSESRVLHFASPSFDASVFELMMAVSAGATLVVAPTTIFGG-EELAEFL 4967 Query: 712 SRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHY 771 + + V+ L V V G+ P E+ R+A + N Y Sbjct: 4968 AEQEVSHAFCTPAALASVNHRGLD----SLTTVVVAGDVCPPELVARWAP--GRVMVNAY 5021 Query: 772 GPTEAVVCS--THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQ 829 GP+EA + S T +V G + V IG P V VLD +L PVP V GELY+ GS Sbjct: 5022 GPSEATIMSSATGPLVPG----QPVTIGSPTVGVDLVVLDSRLRPVPAGVRGELYVLGSS 5077 Query: 830 LARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGE----LEFVGRADEQVKIRG 885 LARGY+ R LTA+RF+A PF G R+YRTGD+VR + LEF+GR+D QVKIRG Sbjct: 5078 LARGYVRRSGLTAERFVASPFGSGGRMYRTGDVVRWVTAPDRPPVLEFLGRSDFQVKIRG 5137 Query: 886 FRIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPA-AAQVDLEEIRAHTAAAV 943 FRIELGE+++ +T HP V + + +G L +Y++PA AA+VD + + Sbjct: 5138 FRIELGEIDAALTAHPVVEFAHTIGFDDGSGHDRLVSYVLPAPAAEVDSRVLSEFVGERL 5197 Query: 944 PEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGR 1003 P YMVP + V+ +P+T +GKLDR ALP P + P+T E+ I ++FA + G Sbjct: 5198 PGYMVPSSIMVLDSLPLTPAGKLDRNALPTPVFAQRSEFTAPQTPAEQAIAAVFADVVGE 5257 Query: 1004 QRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDF 1063 +G +D+FF LGG+SL A ++V+++ + G ++VRT+FD PT LA Sbjct: 5258 PSIGLDDNFFDLGGNSLSATQVVSRVGSALGTRISVRTLFDNPTVRALATA--------- 5308 Query: 1064 ELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLAL 1123 AA D + RP V RP +PLS +Q WF + + + +PLAL Sbjct: 5309 -------AASDTTAE----RPALVAGERPATIPLSPAQQRMWFLNQFDTTAAAYTIPLAL 5357 Query: 1124 RFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDD 1183 R G RHEALRT + E +Q++ P ++ L + +D Sbjct: 5358 RMSGRIDVATLRTALGDVLARHEALRTVYPATENGAHQVIVPVESIPLDLTPTRLSG-ED 5416 Query: 1184 VSTQLRRHV---FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAY 1240 +S + RH F + L+ +L HVLL +VHHI +D S + D++ +Y Sbjct: 5417 LSGAILRHASAGFDVTTDLPLRVHLFRESRSEHVLLFVVHHISADGWSFIPLASDVMTSY 5476 Query: 1241 RARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVA 1295 AR +AP W+ LP+Q+ADYA+WQR+ + +++ YW+ LAGLPD++++ Sbjct: 5477 AARTAGDAPVWNALPVQYADYAMWQRHLLGDSDDPQSLAASQIAYWKRTLAGLPDQVALP 5536 Query: 1296 TDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDI 1355 TDR RP G + ++ L +LA + A+ FM+ ALA +L +LG G D+ Sbjct: 5537 TDRPRPPAPSNLGGTARLTLDGDLHRQLHELARAHHASLFMVVHTALAALLSRLGAGPDV 5596 Query: 1356 ALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIE 1415 A+G+ VA R E + LVG+F N +VLRTD+ D T ++L R L+A +H E+P E Sbjct: 5597 AVGTSVAGRGEQSLDGLVGMFVNTLVLRTDVHPDSTGAALLEQVRRVDLEAFSHVEVPFE 5656 Query: 1416 RLVEALNPPRALSRNPLFQ 1434 +LV+A+NP R+ + +PLFQ Sbjct: 5657 QLVDAINPTRSTAFHPLFQ 5675 Score = 595 bits (1535), Expect = e-167 Identities = 476/1523 (31%), Positives = 703/1523 (46%), Gaps = 114/1523 (7%) Query: 35 GICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVD----EDRLHTAVNDVVA 90 G P + LS QR MWF Q +DP V + I L G +D + L TA ++ + Sbjct: 29 GRIPDGAFPLSAAQRGMWFAQQLDPS-VPVTIAQCVELVGALDVALLSESLITAGRELGS 87 Query: 91 RHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDL 150 A LR V+ +G PYQ+ +E DL P+ E+ P D+ Sbjct: 88 --AFLRL---VEVDGVPYQLIDPTLEASVSVVDLQHEPDP--RAAATEWMRQEYTTPLDV 140 Query: 151 TNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSV 210 + + V+R + VHH+ D + Y A + Sbjct: 141 CRDRLVTSAVLRIGPNHHYWYCRVHHVALDGMGSVTLVDRTAELYTAAVEGRAVAPSKAA 200 Query: 211 EVLQ--------NSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAG 262 E+ +++ +AD YW+E R V P R R G Sbjct: 201 ELTDVARVDDEYRTSSRYLADGEYWSE--RVSSIGEPHSLVDRTAPARARSRTTGGQILG 258 Query: 263 -LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALG-YFG 320 L ++ + +S ++AA+ + R TG + VS+PVT R+ A G Sbjct: 259 PLADHLDAATNRHDSSAAFEVIAAFAAYLARMTGREEVAVSLPVTARTTALLRRSGGMVS 318 Query: 321 NTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRL 380 N + LR+ R T T V VR HQ + R+A + G G + V L Sbjct: 319 NVVPLRLDVRPDMTNTDLVAAVRLEVTGALRHQRYPHMDIRRDAATDHQGFYGPLINVML 378 Query: 381 GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQ 440 N + L G +V +L L + L++ + S+ + + D Sbjct: 379 FHNE------ITL-GSIVGRLELLSTGPISDLAVNVYHGVAGTSINLDLEANPDLYSDDA 431 Query: 441 MLVHYLQL-------VDKALAEPERPLSSLDILGAGE-RDSVLAQSHGELVEMPATTMVK 492 + H+ + + P R + L+IL E R V A + ++ Sbjct: 432 LAAHHARFTRFLGAFLTSDTGTPRR-IGDLEILDEDECRILVPAAGRAGFAPVALPDLLA 490 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 + + L+Y L +NRLAR I GPE + L + S+E Sbjct: 491 GAVRSNPDGDALVAPGHGTPDVTLSYRALDEESNRLARLLIDLQVGPEVSVALALPRSVE 550 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-------GRPEL-------- 597 + ++ AV K+GAA++P+DP YP ERI +++ D I G P+ Sbjct: 551 SVSSVWAVAKSGAAFVPVDPGYPFERIVHMLEDCGAPIGITTAALRAGLPDSTLWLVLDD 610 Query: 598 -DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 + AA +D P++D+DR L H AYVIYTSGSTGRPKGVAVSH + Sbjct: 611 DEFVSAVAAYPAD-PVTDADRTGVLMVDHPAYVIYTSGSTGRPKGVAVSHRGVVNLAADE 669 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGV 716 ++A+ R L F+S SFDAS+ ++ + + GA L+V FG + +A+ ++ V Sbjct: 670 RDRLGVSADSRVLHFASPSFDASVFELVMAVCAGAALVVAPTTMFGGVE-LAEFLAEHEV 728 Query: 717 TVXXXXXXXXXXXXXXXXXXQWRQLRH---VPVGGEALPGEVADRFAGYFDAELRNHYGP 773 + R L H V V G+ P E+ ++A + N YGP Sbjct: 729 S-------HAFCTPAALASLDHRGLDHLTTVVVAGDVCPPELVAKWAP--GRIMVNAYGP 779 Query: 774 TEAVVCS--THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLA 831 TE + S T +V G + V IG V VLD +L PVP V GELY+ GS LA Sbjct: 780 TETTIMSSATGPMVPG----QPVTIGSATVGVDLVVLDHRLRPVPVGVRGELYVLGSSLA 835 Query: 832 RGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGE----LEFVGRADEQVKIRGFR 887 RGY+ R LTA+RF+A PF G R+YRTGD+VR + LEF+GR+D QVKIRGFR Sbjct: 836 RGYVHRAGLTAERFVASPFGTGGRMYRTGDVVRWGTVPDGPPVLEFLGRSDFQVKIRGFR 895 Query: 888 IELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPA-AAQVDLEEIRAHTAAAVPE 945 IELGE+++ ++ HP V V + +G L +Y++PA V+ + +P Sbjct: 896 IELGEIDAALSAHPVVEFAHTVGYDDGSGRSRLVSYVLPAPGTDVETRVLSEFVGTRLPG 955 Query: 946 YMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIA-TRRYREPETATERWICSIFAQLFGRQ 1004 YMVP + V+ +P+T +GKLDR ALPAP A + P T +E + IF + G Sbjct: 956 YMVPSSIMVLNMLPLTPAGKLDRNALPAPVFAARSADIVRPRTVSEEILLGIFRDVLGLP 1015 Query: 1005 RVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFE 1064 + + SFF LGG+SL+A ++V+++ A V + VR +F +P+ + LAA + Sbjct: 1016 ELSVDTSFFELGGNSLMATQVVSRVNAALDVRIGVRDLFQSPSVSKLAATVA-------- 1067 Query: 1065 LDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALR 1124 N P RP RP R+PLS +Q WF + + A +N+P+ALR Sbjct: 1068 ----NAGPQSDP------RPALEPRERPDRMPLSVAQQRMWFLNQFDTASAAYNLPIALR 1117 Query: 1125 FEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQD--EFD 1182 G RHEALRT F + P+Q++ P+ +V +D D Sbjct: 1118 LAGALDREALRAALGDVQERHEALRTVFPDSADGPHQLIKPAVSVLADTDPLDVDPESLT 1177 Query: 1183 DVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRA 1242 T L F + L+A L P+ HVL+L+VHHI +D S+ + D++VAY A Sbjct: 1178 AAVTALGSTGFDLTADTPLRAGLFREAPERHVLVLVVHHIAADGWSMTPLAADVMVAYAA 1237 Query: 1243 RLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEISVATD 1297 R +AP W LP+Q+ DY++WQR+ S + ++ +WR ALAG+P I + TD Sbjct: 1238 RAAGHAPIWAPLPVQYVDYSLWQRDLLGSEDDPNSLSAKQIAHWRAALAGVPQLIELPTD 1297 Query: 1298 RARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIAL 1357 R RP + RG V+F++PA L LA+ G T FM+ AALAV+L +LG G+DI + Sbjct: 1298 RTRPAEMSHRGGRVEFTIPADVHGRLVDLAQSTGTTPFMVTHAALAVLLRRLGAGSDIVI 1357 Query: 1358 GSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERL 1417 G+PVA R E A LVG+F N + LRT + T +L +R L A H ++P ERL Sbjct: 1358 GTPVAGRGEEALDHLVGMFVNTLALRTTVDLGDTFEDVLARTRAADLAAFQHGDVPFERL 1417 Query: 1418 VEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGM 1477 VE L+P R+ + +PLFQ ML F ++ A +L G E + V L L + Sbjct: 1418 VEVLSPARSSAHHPLFQVMLTF--QNTANTRVELDGL-EVEAAEIDVQVAKFDLHLTVAE 1474 Query: 1478 SVTPSGE---LDVQVIANADLYE 1497 +V +G L VQ+ DL++ Sbjct: 1475 NVDAAGNAAGLAVQLSYATDLFD 1497 Score = 591 bits (1524), Expect = e-166 Identities = 402/1065 (37%), Positives = 543/1065 (50%), Gaps = 63/1065 (5%) Query: 34 PGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHA 93 P + P E LS Q+RMWFL DPD NI VA RL+G++D D L AV DV+ RH Sbjct: 8510 PAVRP-ELLPLSSAQQRMWFLNRFDPDSAVHNIPVAVRLSGVLDVDALQHAVADVLHRHE 8568 Query: 94 ILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNE 153 LRT Y +G P+QV VG +A E + +L AD FD+T E Sbjct: 8569 SLRTIYPDSADG-PHQVILSTDRVGAETS-----VDAADEAALPALIADLVTTGFDVTAE 8622 Query: 154 LPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPIND 202 +P+R+ + R A E VL +VVHHI D S ++ AAY+ LP+ Sbjct: 8623 VPVRVRIFRISATEHVLAVVVHHISGDGWSMAPMVRDVMAAYSARSAGTSPDWAPLPVQY 8682 Query: 203 PAAQFLSVEVLQNSAAP-SVA--DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR-- 257 ++L + P SVA + +W +TL P + R Sbjct: 8683 ADYALWQRDLLGDETDPDSVAARQLAFWTQTLAGAPDQLDLP-TDRPRPAVASYRGGTVD 8741 Query: 258 -PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL 316 +PA L V AR +AS FMV+ +A VL+ R G+ D + PV R L Sbjct: 8742 FTVPADLHGTVVGAARDANASVFMVVHSALAVLLSRLAGSGDISIGTPVAGRGERELDDL 8801 Query: 317 -GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM-GRDGM 374 G F NTL+LR TF + +VRET LA F+H V +R+V NP R GR + Sbjct: 8802 IGMFVNTLVLRQHVDGGRTFAELLADVRETDLAAFSHADVPFERLVEVVNPSRSTGRHPL 8861 Query: 375 DLLVRLGFNMRKSA---GGLALDGVVVRQLGLGAVAAHLPLSLTIALD----PDDVSVEF 427 ++ N+ + + G L++ GV L + L L+L D PD ++ Sbjct: 8862 FQVMLTFQNLDQESLELGDLSVSGV---DLDVDIAKFDLQLTLMEQFDSEGGPDGIAARL 8918 Query: 428 EYQQQLSSVLVDQMLVH-----YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGEL 482 Y ++ L D+ H +LQ++ A+ P+ + LD+LG GER + + Sbjct: 8919 TY----AADLFDEPSAHVFGQRFLQVLRAAVDGPDTAVGDLDVLGRGERKQIAGTN---A 8971 Query: 483 VEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDI 542 P V D ELTY+ R NRLAR I QG GPE + Sbjct: 8972 TAHPVLAGTLASLFDTAVAADPDRIAVVFDRDELTYANFDARVNRLARRLIEQGVGPESV 9031 Query: 543 IGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI---------- 592 + + M SI+ +V + AV+KAG AYLPIDP +P ER Y++ ARP V+ Sbjct: 9032 VAVAMRRSIDLLVGIYAVVKAGGAYLPIDPDHPVERTAYVLDTARPACVLVSGAGLADSG 9091 Query: 593 GRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEH 652 P +D+A + P++D DRLRPL + AYVI+TSGSTGRPKGVAV+H AI Sbjct: 9092 SVPVVDIASEDLSRYGSAPVTDRDRLRPLTAANTAYVIFTSGSTGRPKGVAVTHGAIVNR 9151 Query: 653 VQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLIS 712 + E+ +T+ D LQ + V+FD S+ ++F L +GA +++ PD D Y+ L+ Sbjct: 9152 LLWMQHEYALTSADVVLQKTPVTFDVSVWELFWPLQVGASMVIAAPDGHRDPRYLTGLVQ 9211 Query: 713 RRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYG 772 R VT LR V GEAL E RF G A L N YG Sbjct: 9212 ERHVTTMHFVPSMLSVFTAEPAVAVCDSLRLVFCSGEALTPEQVSRFRGVSGAGLHNLYG 9271 Query: 773 PTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLAR 832 PTEA V T TG VPIG P N +VLD +LHPVP+ V GELYL G QLAR Sbjct: 9272 PTEAAVDVTFWE-TGESDTHSVPIGRPVWNTQVHVLDARLHPVPNGVAGELYLAGEQLAR 9330 Query: 833 GYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGE 892 GYLGR LT+ RF+A+PF G R+YRTGDLVRR G LE++GR D QVK+RG RIELGE Sbjct: 9331 GYLGRVDLTSDRFVANPFVAGGRMYRTGDLVRRRGDGALEYLGRTDFQVKLRGQRIELGE 9390 Query: 893 VESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGA 951 +ES + HP V +VV E G L AYLV A + ++RAH + VP YM+P Sbjct: 9391 IESALEAHPDVVQAVVVVHRDERGDEALVAYLVGRRA-AEWSDVRAHLSTRVPSYMIPAR 9449 Query: 952 FAVIPEIPMTVSGKLDRRALPAP-TPIATRRYREPETATERWICSIFAQLFGRQRVGAED 1010 + +P++V+GKLDR+ALPAP A Y+ P +A ER + ++F ++ RVGA D Sbjct: 9450 VVHLDTLPLSVNGKLDRKALPAPEVRSAAAEYQPPRSAAERAVATVFGEVLEIDRVGATD 9509 Query: 1011 SFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 SFF LGG+SL+A R+ A + +E G+D ++ +F PTP L R+ Sbjct: 9510 SFFDLGGNSLIATRVAAALGSELGIDFPLQWMFSDPTPRSLGQRI 9554 Score = 43.5 bits (101), Expect = 0.26 Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 14/117 (11%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMT 1616 E+ER + A+ ELL ++ + D+N+F LGG+S+ A K S + G A VF+ T Sbjct: 6306 ESERVVAAVFAELLGVSRVGVDDNFFELGGNSLSATKLSTRIGVATQTRIAIRDVFDAPT 6365 Query: 1617 IAELAAAVDAANGEPVVEADPPPAQEYTPMSAS---GLAPDALAKLSASWLQQGSAS 1670 +A LA +D P+ P++A+ G P +LA+ +L Q S Sbjct: 6366 VAALARRLDQHG----------PSTAIAPLTAAVRPGRIPLSLAQQRMWFLNQFETS 6412 Score = 41.2 bits (95), Expect = 1.3 Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 6/76 (7%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTIA 1618 ER + + E+LEI + +++F LGG+S+IA + +A G+ LG+ FP +F T Sbjct: 9489 ERAVATVFGEVLEIDRVGATDSFFDLGGNSLIATRVAAALGSELGIDFPLQWMFSDPTPR 9548 Query: 1619 ELA-----AAVDAANG 1629 L AA+D G Sbjct: 9549 SLGQRIQNAAIDGVPG 9564 Score = 38.5 bits (88), Expect = 8.3 Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 6/82 (7%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 ER + ++ +L + + +++F LGG+S+IA + S G L +P +FE T+A Sbjct: 3120 ERAVASVFCAVLGLERVSVRDSFFELGGNSLIATQLVSRLRGELDVPVTVRDLFETPTVA 3179 Query: 1619 ELAAAVDAANGEPVVEADPPPA 1640 ELAA + + G AD PA Sbjct: 3180 ELAARLSQSTG-----ADTRPA 3196 >tr|C7MU85|C7MU85_SACVD Tax_Id=471857 SubName: Full=Non-ribosomal peptide synthase/amino acid adenylation enzyme;[Saccharomonospora viridis] Length = 7310 Score = 805 bits (2078), Expect = 0.0 Identities = 545/1456 (37%), Positives = 754/1456 (51%), Gaps = 97/1456 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS QRR+WFL M+ T N+ + R+ G +D + + A+ D+V RH LRT + Sbjct: 4710 ERVPLSFAQRRLWFLYQMEGPSATYNVPLMLRIRGDLDVEAMAAALTDLVHRHETLRTLF 4769 Query: 100 GVDTEGEPYQVF-SDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRI 158 D +G +V ++DV V ++T E G ++ ++A EF L E+P+ Sbjct: 4770 QADEDGPWQRVLPAEDVRVELVPVEVT---EDGLAERLRAVARYEFA----LHAEIPVHP 4822 Query: 159 TVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA-AQFLSVEV 212 + R ADE VL++VVHHI D S+E F +L+ AY + P+ +P Q+ + Sbjct: 4823 RLFRLSADEHVLVVVVHHIATDGWSYEPFVRDLTTAYLARRSGEPPVWEPLPVQYADYAL 4882 Query: 213 LQ----------NSAAPSVADVGYWAETLRXXXXXXXXX--GVSGANPCRRAQRRVRPLP 260 Q NSA A + YW + L A R R +P Sbjct: 4883 WQQAHLGHEHDRNSAV--AAQLAYWRDALADLPEELNLPFDRPRPAVATYRGDRVEFTVP 4940 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A L R+ AR+ + MVL AA L+ R +D + P+ R+ A L G+F Sbjct: 4941 ADLSERITAVARERRVTVVMVLQAAVAALLTRLGAGTDIPMGSPIAGRTDEATNDLIGFF 5000 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLV 378 NTL+LR T TF ++ VR+ LA +AHQ + +R+V NP R M R L Sbjct: 5001 VNTLILRTDTSGDPTFGELLDRVRKVDLAAYAHQDIPFERLVEVVNPTRSMARHP---LF 5057 Query: 379 RLGFNMRKSA------GGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ 432 ++ F++ + A L+ G+ VR+ + A A LS + + E+ Sbjct: 5058 QVLFSVSQFAPRDDTVSTLSGAGIEVRRESIEARIAKFDLSFSFTRSDAEWRGMIEFSVD 5117 Query: 433 L-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMV 491 L V M L+L+ A+A P+ P+ +L +L + ER VL + + P T + Sbjct: 5118 LFDRETVTAMSERLLRLLAAAVAAPDVPIGALPVLDSVERRRVLTEWND--TAHPVETGL 5175 Query: 492 KXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSI 551 D LTY+EL +ANRLA + +G E ++ + + + Sbjct: 5176 LESFQAQVAATPDAIALAYGD-GTLTYAELDAKANRLAAFLRARGAASERLVAVALPRTP 5234 Query: 552 EFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL-------------- 597 + +V +LA+LK GAAYLPID YP +RI Y+ DA P + EL Sbjct: 5235 DLLVTLLAILKTGAAYLPIDTGYPADRISYMFDDAAPALAVTTGELVERVPTREGTQVLL 5294 Query: 598 ----DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHV 653 DV + A++ D P D AYVIYTSGSTGRPKGV V+ + + Sbjct: 5295 LDDPDVIDAVDAESEDFPTIPRDA------DTAAYVIYTSGSTGRPKGVVVTSANLDNFL 5348 Query: 654 QGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISR 713 + A+DR L +++ FD + ++F+ L GA++++ PD D + V L R Sbjct: 5349 VDMRGRIGLDADDRLLAVTTIGFDIAALELFLPLVSGARVVLADPDVVRDPAAVVRLCER 5408 Query: 714 RGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGP 773 GVT + L VGGEALPG+VA G A + N YGP Sbjct: 5409 AGVTAIQATPSWWRALVQDGETGRL-DLGTALVGGEALPGDVARALTG-IAASVTNVYGP 5466 Query: 774 TEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARG 833 TE + ST VTG R IGVP N +VLDE+L PVP V+GELY+ G+ +ARG Sbjct: 5467 TETTIWSTAASVTGEPDMRP-SIGVPIGNTSVFVLDERLAPVPVGVVGELYIAGAGVARG 5525 Query: 834 YLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGE 892 YLGRP LTA+RF+A PF PG R+YRTGDLVR G L +VGR D+QVK+RGFRIELGE Sbjct: 5526 YLGRPGLTAERFVACPFGEPGERMYRTGDLVRWLSDGTLAYVGRVDDQVKLRGFRIELGE 5585 Query: 893 VESVITTHPAVRHCLVVAEETEAGP-MLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPG 950 +ESV+ P V VV E G L Y+VPA + D + A + +P+YMVP Sbjct: 5586 IESVLRELPEVAGAAVVVREDRPGDHRLVGYVVPAPGVEPDRARLVAQLRSRLPDYMVPA 5645 Query: 951 AFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAED 1010 AF V+ E+PMT +GKLDRR+LPAP A R P E + +FA + G VG +D Sbjct: 5646 AFVVLDELPMTPNGKLDRRSLPAPQLEAAAASRAPRNPREEILAELFADVLGVSTVGIDD 5705 Query: 1011 SFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNL 1070 FF LGGHSLLA RLV+++R+ GV+L++R +F+APT AGL+A L D Sbjct: 5706 DFFALGGHSLLATRLVSRVRSTLGVELSLRALFEAPTVAGLSAAL------------DGA 5753 Query: 1071 AADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXX 1130 A P P P RLPLS++Q WF +R+EG +N+PLALR G Sbjct: 5754 QATGRPALRAVESP-------PDRLPLSYAQRRLWFLHRMEGPSATYNVPLALRLIGTLD 5806 Query: 1131 XXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRR 1190 RHE LRT E + PYQ V P+ + +L R +D+D+ ++ R Sbjct: 5807 PAALRAALTDVIDRHEPLRTVVAEDDQGPYQRVLPTGSCELHHRRVDEDDLAAELSRAGR 5866 Query: 1191 HVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQ 1250 H F + P ++A L L D +VLL+++HHI +D AS+ + DL AY AR P Sbjct: 5867 HGFELDREPPIRAWLFELAEDENVLLVVMHHIATDGASMSVFLRDLTTAYAARRLGGKPV 5926 Query: 1251 WDILPIQFADYAVWQRNTFESNWGQT-----ELDYWRDALAGLPDEISVATDRARPRVLG 1305 W LP+++ADYA+WQ+ S +++YW+ ALA LP+EI + TDR RP Sbjct: 5927 WKPLPVRYADYALWQQEVLGSETDPNSMLSGQIEYWKTALAELPEEIRLPTDRPRPPESS 5986 Query: 1306 KRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARV 1365 RGE V F+VP L +LA AT FM+ QAALA +L +LG GTDI +G+PVA R Sbjct: 5987 YRGERVHFTVPTELSRRLAELAATRQATVFMVVQAALAALLTRLGAGTDIPIGTPVAGRT 6046 Query: 1366 EPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPR 1425 + AT +LVGLF N +VLRTD SGDP+ +L R+ L A A+Q+LP ERLVE + P R Sbjct: 6047 DEATDELVGLFVNTLVLRTDTSGDPSFTELLDRVREVDLGAYANQDLPFERLVEIVKPAR 6106 Query: 1426 ALSRNPLFQNMLNFRG 1441 AL+R+PLFQ ML F G Sbjct: 6107 ALNRHPLFQVMLTFAG 6122 Score = 759 bits (1961), Expect = 0.0 Identities = 550/1548 (35%), Positives = 763/1548 (49%), Gaps = 144/1548 (9%) Query: 26 AAEQSSD-QPGICPGERYRL---SDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRL 81 AAE+ D +P + P R S Q+R+WFL DP+ +I VA RL G +D + Sbjct: 1045 AAEREDDTRPALLPRPRPETVPASFAQQRLWFLNRFDPESAAYHIPVALRLTGELDATAM 1104 Query: 82 HTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAA 141 A+ DVVARH +LRT Y +G V +D + L RL + +++ A Sbjct: 1105 VDALADVVARHEVLRTVYDDGPDGAVQIVLPEDRA----KVTLPRLRIRADD--LDARLA 1158 Query: 142 DEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND---- 197 D RPFDLT +LPLR + DE VLLLV+HHI D S +L+AAY Sbjct: 1159 DCVRRPFDLTTDLPLRAWLFELAPDEHVLLLVLHHIAADGWSMGPLARDLTAAYRARTAG 1218 Query: 198 -------LPIN--DPAAQFLSV---EVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSG 245 LP+ D A V E Q+SA + D +W TL + Sbjct: 1219 TAPRLPALPVQYADYALWQRDVFGDETDQDSAIRAQLD--HWRRTLADLPEELGLRRSTV 1276 Query: 246 ANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPV 305 A + + L + + R+ A+ FMV AA ++ R +D + P+ Sbjct: 1277 AETTTPPEPVTVEIDGELHAALVALCRQRRATLFMVFQAALAGVLSRLGAGTDIPIGTPI 1336 Query: 306 TERSG-AAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREA 364 R A A ++G+F NTL+LR T ++ VRE L +A+Q V +R+V E Sbjct: 1337 AGRGDDALAESVGFFVNTLVLRTDVSGNPTVAELIDRVREVALTAYANQDVPFERLVEEL 1396 Query: 365 NPERMGRDGMDLLVRLGFNMRKSAGGL----ALDGVVVRQLGLGAVAAHLPLSLTIALDP 420 NP+R V L FN L L G+ + A A + L+LT+ + Sbjct: 1397 NPDRSTDRHPLFQVMLTFNNVDQQAALDTIHELPGLRAEGYPVAAGEAKVDLALTVTENF 1456 Query: 421 DD--------VSVEFE---YQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAG 469 D V+++F Y++ L D+++ +++ L ER + +++L A Sbjct: 1457 TDDAAPAGLRVTIQFRGDSYERAWVRDLADRLV----RMLSGFLTASER-VDRIELLSAE 1511 Query: 470 ERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLA 529 ER + S + P + +D EL Y+EL A+R+A Sbjct: 1512 ERSRITGWSGLGVAPTPGALLPDLIAEQAARTPDAVAVS--ADGVELRYAELLALADRVA 1569 Query: 530 RWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQ 589 R G GPE ++ + + S++ +VA+LAV +AG Y+PIDP P +R+ YLI+DARP Sbjct: 1570 RALRRAGVGPERLVAVLLGKSVDLLVALLAVWRAGGGYVPIDPDQPADRVAYLISDARPV 1629 Query: 590 TVIGRPEL------DVAERAAADNSDLPLSDSDRLRP----LRPGHLAYVIYTSGSTGRP 639 + P+L D D D + + P PG +AYVIYTSGSTGRP Sbjct: 1630 LTLTEPDLAAHLPPDTPTLIVRDLVDESSATTPSTAPPPAVTSPGQIAYVIYTSGSTGRP 1689 Query: 640 KGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPD 699 KGVA+ H A+A +V+ + A L +S+ FD ++ +F L LG ++++ Sbjct: 1690 KGVAIPHEALAAYVRRSARAYP-DAGGVSLAHTSIGFDLTVTALFTPLVLGGRVVLSDSI 1748 Query: 700 AFG-----------DISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGG 748 G ++ +ADL T+ +GG Sbjct: 1749 EDGAEATFTKATPSHLTLLADLPEIAPSTLV--------------------------LGG 1782 Query: 749 EALPGE-VADRFAGYFDAELRNHYGPTEAVV-CSTHMVVTGSH-GARVVPIGVPNRNVYA 805 EAL G+ +AD A + D + N YGPTE V C+ V G+ VPIG P Sbjct: 1783 EALTGQALADWRADHPDTTVVNAYGPTELTVNCTEFTVPPGTVLDPGPVPIGRPFPGTAV 1842 Query: 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVR 864 +VLD L PVP +GELY+ GS LARGYL RP L+A+RF+A PF PG R+YRTGDLVR Sbjct: 1843 FVLDRGLRPVPVGTVGELYVAGSGLARGYLRRPGLSAERFVACPFGEPGARMYRTGDLVR 1902 Query: 865 RNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAV-RHCLVVAEETEAGPMLAAY- 922 + G+L +VGRAD+QVK+RGFRIE GE+ESV+ P V R +V+ ++T L Y Sbjct: 1903 WSPDGDLVYVGRADDQVKVRGFRIEPGEIESVVADCPGVLRAVVVLRDDTPGERRLVCYA 1962 Query: 923 LVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRY 982 L + V E + +P ++VP AF V+ E+P+T +GK+DRR+LPAP P R+ Sbjct: 1963 LAEPGSDVTPERLAEWAGERLPTHLVPSAFVVLDELPLTANGKVDRRSLPAP-PTTNRKS 2021 Query: 983 --REPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVR 1040 R P T E +C +FA+ G V +D FF LGGHSLLA RL+ ++RA GVDL +R Sbjct: 2022 TGRAPRTPVEEILCGLFAEALGVAAVTVDDDFFALGGHSLLAMRLMNRVRAVLGVDLRLR 2081 Query: 1041 TIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHS 1100 +FD PT AGLA + R V RP R PLS + Sbjct: 2082 ALFDTPTVAGLAEGIARG---------------------AGVRRALVGRPRPARPPLSFA 2120 Query: 1101 QLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPY 1160 Q WF Y ++G +N+P+ALR G RHE+LRT + E Y Sbjct: 2121 QQRLWFLYELDGPSPTYNVPMALRLSGDLDVAALRLALRDVVARHESLRTVIESDEHGAY 2180 Query: 1161 QIVHPSRTV--QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLI 1218 Q + P V +LAV +D+ D H F + ++A L + P HV LL+ Sbjct: 2181 QRIVPVEAVDVELAVETLDEARLADALADNVGHGFALDRDIPVRAWLYRIAPREHVFLLL 2240 Query: 1219 VHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTEL 1278 VHHI +D S + DL VAY AR + PQW P+Q+ADYAVWQR T G TE Sbjct: 2241 VHHIATDGWSKGPLTRDLTVAYAARRRGRQPQWSPCPVQYADYAVWQRETL----GDTER 2296 Query: 1279 D---------YWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAER 1329 D YWRDALAGLPDE+++ DR RP V RG+ V+F+V A A L +LA Sbjct: 2297 DDSVLARQLAYWRDALAGLPDELNLPVDRPRPAVPSHRGDRVEFTVDAKLHARLAELARA 2356 Query: 1330 NGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGD 1389 +G T FM+ QAALA +L +LG GTDI +GSPVA R + AT +VG F N +VLRTD G+ Sbjct: 2357 HGVTVFMVLQAALATLLTRLGAGTDIPIGSPVAGRDDEATNDVVGYFVNTLVLRTDTEGN 2416 Query: 1390 PTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPR 1449 PT +L R T L A AHQ++P E LV+A+ P R+L+R+PLFQ ML F D + P Sbjct: 2417 PTFAELLARVRRTNLAAYAHQDVPFELLVDAVQPERSLARHPLFQVMLAFNSTDHEVPPE 2476 Query: 1450 DLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 TV P+ A L G + SG L V + DL++ Sbjct: 2477 SAMADSGLTVTPVRTPTTSAKFDLLFGFAEEESGGLVCSVEFSTDLFD 2524 Score = 701 bits (1808), Expect = 0.0 Identities = 500/1410 (35%), Positives = 711/1410 (50%), Gaps = 75/1410 (5%) Query: 72 LAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAG 131 L G VD R+ AV + RHA LR + GE Q+ V + DL +A Sbjct: 46 LTGSVDVGRMRNAVAGLFDRHAGLRLCFRQVRSGEWVQIVQRRVATPFEVVDLCDASDA- 104 Query: 132 HERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGEL 191 + ++ L E R FD+T+ R ++R+ D ++ HH+ WD S V EL Sbjct: 105 -DAELRRLIERERSRGFDVTSGPLARFVLVRSSEDTFRFVVTHHHVLWDGWSVPVLLREL 163 Query: 192 SAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRR 251 A Y + + A F ++ ++N S + +WAE L G G +P + Sbjct: 164 LALYRGEHL-EQAPDFGAL--VRNVLGLSGSGRRFWAERLSGVEPCLVSDG--GVDPGQL 218 Query: 252 AQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSG- 310 R L + DFAR+ A+ +V+ AA+GV++ G D + + V+ R Sbjct: 219 PGSVTRELTVAASRGLRDFARRHGATLSVVVQAAWGVVLSSLLGRDDVVFGMTVSGRPDG 278 Query: 311 --AAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER 368 AA +G F NT+ RI + ++ V+ V+E +Q DR+V Sbjct: 279 VPAAEDVVGLFINTVPARIVLGAGESAPELVSRVQEDFGRTLDNQ---FDRLVDIQAAAG 335 Query: 369 MGRDGMDLLVRL-GFNMRKSAGGLALDGVVVRQLGL-GAVAAHLPLSLTIALDPDDVSVE 426 G + D +V + + + AG LD R + G A H PL LT+ + + V++ Sbjct: 336 HGGELFDTVVVFENYPLGEFAGKTELDVEDFRVTSVEGRDATHYPLLLTV-VPGNTVALR 394 Query: 427 FEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM 485 +++Q L +L ++++D+ + +P+ P++ +D+L ERD VL + VE Sbjct: 395 LDHRQDLFDEAAATAVLDRLVRVLDRFVTDPDGPVARIDLLTDVERDRVLHHWNDTAVEH 454 Query: 486 PATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGL 545 P TT+ + V + LT++EL RANRLA + +G G EDI+ L Sbjct: 455 PPTTLPEAFARRAAETPEATAL--VFGKTTLTFAELDMRANRLAHLLLSRGVGAEDIVAL 512 Query: 546 RMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAA 605 + S E IVA+LAVL+ GAAYLP+D P +R+ Y++TDARP V+ D+ + A Sbjct: 513 AIPRSAETIVALLAVLQTGAAYLPVDLDQPADRVAYVLTDARPTLVLTTITSDLPDHPAP 572 Query: 606 DNS-DLPLS-------------DSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIA- 650 D P++ D DR+ P+ P H AYVIYTSGSTGRPKGV ++H + Sbjct: 573 TLVLDDPVTEAALLAAPTRNPHDVDRVVPMHPAHPAYVIYTSGSTGRPKGVVLTHAGLRN 632 Query: 651 ---EHVQGFVAEWT-MTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISY 706 +HV G + T R +++SFD S + + L G +L + + D Sbjct: 633 LYHDHVAGLIEPHAPKTRRLRTGLSAALSFDTSW-ECLLCLVAGHELHLLDDETRRDADL 691 Query: 707 VADLISRRGVTVXXXXXXXXXXXXXXXXXXQ-WRQLRHVPVGGEALPGEVADRFAGYFDA 765 + ++ + + + + + +GGEA+P + R Sbjct: 692 LVRYVAEHRLDLLDLTPSHAQELVETGLLAEDGHRPAVLMLGGEAVPPALWTRLRAAPHT 751 Query: 766 ELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYL 825 N+YGPTE V + + S IG P N AYVLD L PV V GELYL Sbjct: 752 RCYNYYGPTEFTVDAVACALDDSEQPT---IGRPLDNTRAYVLDAALLPVAPGVPGELYL 808 Query: 826 GGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIR 884 G QLARGYLGR LTA+RF+A PF PG R+YRTGDL R G LEF+GRAD QVKIR Sbjct: 809 AGPQLARGYLGRAGLTAERFVACPFGAPGERMYRTGDLARWTEHGTLEFLGRADGQVKIR 868 Query: 885 GFRIELGEVESVITTHPAVRHCLVVAEETE-AGPMLAAYLVPAAAQVDLEE---IRAHTA 940 GFR+ELGEVE + THP+V C VVA E E AG L AY+VP A+ D + + H A Sbjct: 869 GFRVELGEVEHALLTHPSVGQCAVVATEAEPAGTRLVAYVVPRASHTDAVDTGVLARHVA 928 Query: 941 AAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQL 1000 A +P++MVP AF V+ E+P T +GKLDRRALP+P R R P E +C++F + Sbjct: 929 ATLPDHMVPAAFVVLDELPRTQAGKLDRRALPSPDFGVVARGRAPRGPREEILCTLFGDV 988 Query: 1001 FGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFR 1060 +D FF LGGHSLLA++LV+++R+ GV+L++RT+F+ T A LAA L R Sbjct: 989 LRVPPPSIDDDFFALGGHSLLASKLVSRVRSTLGVELSLRTLFETRTVAALAAALDAAER 1048 Query: 1061 NDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMP 1120 D RP + RP+ +P S +Q WF R + +++P Sbjct: 1049 ED------------------DTRPALLPRPRPETVPASFAQQRLWFLNRFDPESAAYHIP 1090 Query: 1121 LALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPS--RTVQLAVRAIDQ 1178 +ALR G RHE LRT +D+ QIV P V L I Sbjct: 1091 VALRLTGELDATAMVDALADVVARHEVLRTVYDDGPDGAVQIVLPEDRAKVTLPRLRIRA 1150 Query: 1179 DEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIV 1238 D+ D R F + L+A L L PD HVLLL++HHI +D S+ + DL Sbjct: 1151 DDLDARLADCVRRPFDLTTDLPLRAWLFELAPDEHVLLLVLHHIAADGWSMGPLARDLTA 1210 Query: 1239 AYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQ-----TELDYWRDALAGLPDEIS 1293 AYRAR AP+ LP+Q+ADYA+WQR+ F Q +LD+WR LA LP+E+ Sbjct: 1211 AYRARTAGTAPRLPALPVQYADYALWQRDVFGDETDQDSAIRAQLDHWRRTLADLPEELG 1270 Query: 1294 VATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGT 1353 + R+ E V + AAL L + AT FM++QAALA VL +LG GT Sbjct: 1271 LR--RSTVAETTTPPEPVTVEIDGELHAALVALCRQRRATLFMVFQAALAGVLSRLGAGT 1328 Query: 1354 DIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELP 1413 DI +G+P+A R + A A+ VG F N +VLRTD+SG+PT+ ++ R+ L A A+Q++P Sbjct: 1329 DIPIGTPIAGRGDDALAESVGFFVNTLVLRTDVSGNPTVAELIDRVREVALTAYANQDVP 1388 Query: 1414 IERLVEALNPPRALSRNPLFQNMLNFRGED 1443 ERLVE LNP R+ R+PLFQ ML F D Sbjct: 1389 FERLVEELNPDRSTDRHPLFQVMLTFNNVD 1418 Score = 687 bits (1772), Expect = 0.0 Identities = 493/1427 (34%), Positives = 700/1427 (49%), Gaps = 98/1427 (6%) Query: 70 YRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPE 129 + L G VD +R+ AV + RH LR + + G QV + V + DL + Sbjct: 3700 FELVGAVDVERMREAVAGLFRRHEGLRVCFRQVSSGSWVQVVARTVTTPFDVVDLRDSDD 3759 Query: 130 AGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFG 189 A ER+ E LA ++ R FD+T+ R + R D ++ HH WD S + Sbjct: 3760 A--EREFERLAEEQRARGFDVTSGPLARFVLARVSEDVFRFVVTNHHAIWDGWSIPIVLR 3817 Query: 190 ELSAAYN-DLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANP 248 +L A Y D P P V++ A S +W L G A Sbjct: 3818 DLLALYRGDEPGRAPGLG----AVVRELVASSGGGREFWGHVL--GGVEPCLIGTGDATG 3871 Query: 249 CRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTER 308 A+ R + + L +R + AR + V+ AA+ V++ D + V+ R Sbjct: 3872 SGAAESLSRVIDSELSARFTELARDNGVTASTVVQAAWSVVLSGLLCRDDVVFGATVSGR 3931 Query: 309 SGAAAG---ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREAN 365 G +G NT+ +R+ + + ++ + HQ DR+V Sbjct: 3932 PDDVEGIRETVGMLINTVPVRVGLTADEPVADLLSRLHREFGRILDHQ---FDRLVDVQT 3988 Query: 366 PERMGRDGMDLLVRL-GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVS 424 +G D D +V F + + + VR++G GA H PL+L ++ ++ Sbjct: 3989 WSGVGGDLFDTVVVFENFPVAEVTEDQKGGDLTVRRIG-GASGTHYPLTLNASMRGRELE 4047 Query: 425 VEFEYQQQLSSVLVDQMLVHYLQ---LVDKALAEPERPLSSLDILGAGERDSVLAQSHGE 481 + YQ L L D++ V L V + +R L LD+L +R +L + GE Sbjct: 4048 LRLLYQPGL---LADEVAVRVLDSFTTVLEGFVAGDRRLGELDLLPRPQRSRLL-RDWGE 4103 Query: 482 LVEM----PATT---MVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIG 534 PA T +V S + LTY+EL RANRLAR + Sbjct: 4104 TGPASPWDPAVTVPELVAEQARRTPEAVAVVCADSTSPASALTYAELDARANRLARRLVE 4163 Query: 535 QGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG- 593 G GPE ++G+ + + + +VA+LAVL+AG AY+PIDP YPD+RIDY++ DA P V+ Sbjct: 4164 LGVGPERLVGVLLGKTPDLVVALLAVLRAGGAYVPIDPEYPDDRIDYVVRDAAPVLVLTD 4223 Query: 594 ------------RPELD--VAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRP 639 R LD A A+ ++ PLSD++R P+ P AYVIYTSGSTGRP Sbjct: 4224 TASATRVPAGHRRLVLDDPATAEAVAELAEGPLSDAERGGPVEPDQAAYVIYTSGSTGRP 4283 Query: 640 KGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPD 699 KGV VS A++ +V+ A + A L SSV+FD +L +F L +G + Sbjct: 4284 KGVVVSVGAMSAYVRRSAAAYP-DAAGSGLVHSSVAFDLTLTVLFTPLAVGGAV------ 4336 Query: 700 AFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRF 759 ++ D + V + +GGEAL G + Sbjct: 4337 ------HLVDRLDEHSAAVDVSLLKVTPSHLPLLEELPELVPSTLVIGGEALFGRALVPW 4390 Query: 760 -AGYFDAELRNHYGPTEAVVCSTHMVVTGS--HGARVVPIGVPNRNVYAYVLDEQLHPVP 816 A + ++ + N YGPTE V V+ G VPIG P +VLD L PVP Sbjct: 4391 RAAHPESTVINAYGPTELTVNCAEFVLPPHTPQGNGPVPIGKPFPGFRVFVLDHWLRPVP 4450 Query: 817 DQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVG 875 V GELY+ G +ARGYLGR LTA+RF+A P+ PG R+YRTGD VR + G LE+VG Sbjct: 4451 VGVPGELYVSGVGMARGYLGRSALTAERFVACPYGEPGQRMYRTGDQVRWSPDGNLEYVG 4510 Query: 876 RADEQVKIRGFRIELGEVESVITTHPAV-RHCLVVAEETEAGPMLAAYL-VPAAAQVDLE 933 R D QVK+RG RIELGE+E+V+ HP V R VV E+T + AYL + V Sbjct: 4511 RVDHQVKVRGHRIELGEIEAVLAEHPEVSRAVAVVREDTAGDRRIVAYLGTDSDTPVSTA 4570 Query: 934 EIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWI 993 ++ AH + +P+YMVP AF + E P+T +GK+DR ALP P T P E + Sbjct: 4571 DVAAHVRSRLPDYMVPSAFVTLAEFPLTANGKIDRAALPEPRTTGTVD-NGPRDPYEEIL 4629 Query: 994 CSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAA 1053 C +FA + VG +D FF LGGHSLLA RL++++R+ GV L +R FD PT A LA Sbjct: 4630 CGLFADVLDVPAVGVDDDFFDLGGHSLLAIRLISRVRSVLGVQLGIREFFDRPTVAALAV 4689 Query: 1054 RLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGA 1113 L +AD P P RP+R+PLS +Q WF Y++EG Sbjct: 4690 GL-------------GRSADAAPSKVVAVSP------RPERVPLSFAQRRLWFLYQMEGP 4730 Query: 1114 REEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAV 1173 +N+PL LR G RHE LRT F E P+Q V P+ V++ + Sbjct: 4731 SATYNVPLMLRIRGDLDVEAMAAALTDLVHRHETLRTLFQADEDGPWQRVLPAEDVRVEL 4790 Query: 1174 RAIDQDEFDDVSTQLR---RHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLE 1230 ++ E D ++ +LR R+ F + + L L D HVL+++VHHI +D S E Sbjct: 4791 VPVEVTE-DGLAERLRAVARYEFALHAEIPVHPRLFRLSADEHVLVVVVHHIATDGWSYE 4849 Query: 1231 IVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDAL 1285 DL AY AR P W+ LP+Q+ADYA+WQ+ ++ +L YWRDAL Sbjct: 4850 PFVRDLTTAYLARRSGEPPVWEPLPVQYADYALWQQAHLGHEHDRNSAVAAQLAYWRDAL 4909 Query: 1286 AGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVV 1345 A LP+E+++ DR RP V RG+ V+F+VPA +T +A T M+ QAA+A + Sbjct: 4910 ADLPEELNLPFDRPRPAVATYRGDRVEFTVPADLSERITAVARERRVTVVMVLQAAVAAL 4969 Query: 1346 LHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLD 1405 L +LG GTDI +GSP+A R + AT L+G F N ++LRTD SGDPT +L R L Sbjct: 4970 LTRLGAGTDIPMGSPIAGRTDEATNDLIGFFVNTLILRTDTSGDPTFGELLDRVRKVDLA 5029 Query: 1406 ALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLT 1452 A AHQ++P ERLVE +NP R+++R+PLFQ + + PRD T Sbjct: 5030 AYAHQDIPFERLVEVVNPTRSMARHPLFQVLFSVS----QFAPRDDT 5072 Score = 533 bits (1374), Expect = e-149 Identities = 447/1396 (32%), Positives = 632/1396 (45%), Gaps = 109/1396 (7%) Query: 23 SGLAAEQSSDQPGI----CPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDE 78 + L Q++ +P + P +R LS QRR+WFL M+ T N+ +A RL G +D Sbjct: 5748 AALDGAQATGRPALRAVESPPDRLPLSYAQRRLWFLHRMEGPSATYNVPLALRLIGTLDP 5807 Query: 79 DRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIES 138 L A+ DV+ RH LRT D +G PYQ R T E H R E Sbjct: 5808 AALRAALTDVIDRHEPLRTVVAEDDQG-PYQ-----------RVLPTGSCELHHRRVDED 5855 Query: 139 LAADEFGRP----FDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAA 194 A E R F+L E P+R + DE VLL+V+HHI D S VF +L+ A Sbjct: 5856 DLAAELSRAGRHGFELDREPPIRAWLFELAEDENVLLVVMHHIATDGASMSVFLRDLTTA 5915 Query: 195 Y-----------NDLPINDPAAQFLSVEVLQNSAAPSV---ADVGYWAETLRXXXXXXXX 240 Y LP+ EVL + P+ + YW L Sbjct: 5916 YAARRLGGKPVWKPLPVRYADYALWQQEVLGSETDPNSMLSGQIEYWKTALAELPEEIRL 5975 Query: 241 XGVSGANP--CRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASD 298 P R +R +P L R+ + A A+ FMV+ AA L+ R +D Sbjct: 5976 PTDRPRPPESSYRGERVHFTVPTELSRRLAELAATRQATVFMVVQAALAALLTRLGAGTD 6035 Query: 299 FLVSVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGI 357 + PV R+ A L G F NTL+LR T +FT ++ VRE L +A+Q + Sbjct: 6036 IPIGTPVAGRTDEATDELVGLFVNTLVLRTDTSGDPSFTELLDRVREVDLGAYANQDLPF 6095 Query: 358 DRVVREANPER-MGRDGM-DLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLT 415 +R+V P R + R + +++ + A DG+ +R+ L A A L + Sbjct: 6096 ERLVEIVKPARALNRHPLFQVMLTFAGTTGEDADRPVDDGLRIRREPLEATVAKFDLLVN 6155 Query: 416 IALDP-DDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDS 473 I P + + E+ L V+ +L L+ + +A+P + + +IL A ER Sbjct: 6156 IVEQPANGLRGVVEFSTDLFDRATVETLLERLLRFLRAVVADPAERIGAHEILTADERHR 6215 Query: 474 VLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFI 533 +LA+ + + AT ++ +A LTY+EL+ RA+RLAR + Sbjct: 6216 LLAEWNDTGTQRTATLPIEQIEKQAALRPDAVAVTHA--DATLTYAELNTRADRLARVLV 6273 Query: 534 GQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG 593 +G PE + + M +++ +VA++AVLK GAAYLPID YP ERI+YL+TDA P + + Sbjct: 6274 ERGAAPERFVAVAMERTVDLVVAVVAVLKTGAAYLPIDHRYPTERIEYLLTDADPVSFLA 6333 Query: 594 R----PELD--VAERAAADNSDLPLSDS-------DRLRPLRPGHLAYVIYTSGSTGRPK 640 P L VAE A L L + R R AY+IYTSGSTGRPK Sbjct: 6334 SSATWPTLAGLVAEEAVLLVDRLELDTAVEGAEPIGRHRSAHRDGAAYMIYTSGSTGRPK 6393 Query: 641 GVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDA 700 GV V+H +AE + E+ + + +S+SFD S+ ++F L +G + + Sbjct: 6394 GVVVTHGNLAELMAWARTEFGAERLAQVVLSTSLSFDVSVFELFAPLSVGGTV-----EI 6448 Query: 701 FGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFA 760 D+ +AD ++ + + + GEALP R Sbjct: 6449 VDDLLVLADRSEAWSASLVSSVPSAFSRLLTGGLLDR-ADIGTLVFAGEALPAATLARIR 6507 Query: 761 GYFD-AELRNHYGPTEAVVCSTHMVVTGSHGARVVP-IGVPNRNVYAYVLDEQLHPVPDQ 818 +E+ N YGPTE V T + + G R P IG P N AYVLDE+L PVP Sbjct: 6508 EVLPHSEVFNLYGPTETTVYCTGGALDVADGGRSAPPIGRPMPNTRAYVLDERLRPVPAG 6567 Query: 819 VIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRA 877 V GELY+ G +++RGY R +LT+ RF+A PF P G R+YRTGDLVR G LEF+ R Sbjct: 6568 VPGELYVAGERVSRGYRRRASLTSTRFVACPFGPLGSRMYRTGDLVRWLPDGRLEFLARV 6627 Query: 878 DEQVKIRGFRIELGEVESVITTHPAVRHCLVVA-EETEAGPMLAAYLVPAAAQVDLEEIR 936 D+QVKIRGFR+ELGE+ESV+ HP V VVA E+T P L AY+V VD ++ Sbjct: 6628 DDQVKIRGFRVELGEIESVVAAHPDVERVAVVAREDTPGEPRLVAYVV---GTVDRADLT 6684 Query: 937 AHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSI 996 ++ AA +PEYM P A+ + ++P+T +GKLDRRALPAP T P E +C + Sbjct: 6685 SYVAARLPEYMAPSAYVELTDLPLTSNGKLDRRALPAPDVEVTTE-ATPRNEREELLCGL 6743 Query: 997 FAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLV 1056 FAQ+ G VG D FF LGG S+L+ +LV R + G+ L+VR +F+ T AGLA Sbjct: 6744 FAQVLGLPEVGITDGFFALGGDSILSIQLVGLAR-QAGLGLSVRDVFEHQTVAGLAT--- 6799 Query: 1057 ERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEG---- 1112 A D+ P + A LPL + + AW R G Sbjct: 6800 --------------VARDL---PTAGTAPVSREAAVGELPL--TPIMAWLHQRDSGSAGS 6840 Query: 1113 AREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLA 1172 A FN + H+ALRT D+ V P +V A Sbjct: 6841 ALAGFNQSRVVAVPAGARYDDVLAAMTAVLEHHDALRTRLDDSGSRWRLFVEPPGSVTAA 6900 Query: 1173 --VRAIDQDEFDDVSTQLR--------RHVFTPESGPLLQANLLVLGPDTH-VLLLIVHH 1221 V +D + D + Q R R P G LQA GP LLL+ HH Sbjct: 6901 DVVSRVDATGWTDETLQKRLVEAAVTARGKLAPTEGIQLQAVWFDRGPHLRGRLLLVAHH 6960 Query: 1222 IVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYW 1281 +V D S ++ DL AY A + + + + ++A E YW Sbjct: 6961 LVVDGVSWRVLLPDLAQAYGASTRGTPAELAPVDVSMREWANALAEHARHPDTAAERPYW 7020 Query: 1282 RDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAA 1341 + L+G+ A D R R Q S LT++ ER A + A Sbjct: 7021 TEVLSGVTPVADRALDPTRDVQATARTLSRQLSTDVTEE-LLTRIPERFRAGINDVLLAG 7079 Query: 1342 LAVVLHKLGGGTDIAL 1357 LA+ L + GGTD + Sbjct: 7080 LAMALTRWHGGTDTVI 7095 Score = 502 bits (1292), Expect = e-139 Identities = 454/1446 (31%), Positives = 644/1446 (44%), Gaps = 131/1446 (9%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL +D T N+ +A RL+G +D L A+ DVVARH LRT D Sbjct: 2117 LSFAQQRLWFLYELDGPSPTYNVPMALRLSGDLDVAALRLALRDVVARHESLRTVIESDE 2176 Query: 104 EGEPYQ----VFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 G YQ V + DVE+ D RL +A AD G F L ++P+R Sbjct: 2177 HGA-YQRIVPVEAVDVELAVETLDEARLADA---------LADNVGHGFALDRDIPVRAW 2226 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA-AQFLSVEVL 213 + R E V LL+VHHI D S +L+ AY P P Q+ V Sbjct: 2227 LYRIAPREHVFLLLVHHIATDGWSKGPLTRDLTVAYAARRRGRQPQWSPCPVQYADYAVW 2286 Query: 214 QNSAAPSVA--------DVGYWAETLRXXXXXXXXX--GVSGANPCRRAQRRVRPLPAGL 263 Q + YW + L A P R R + A L Sbjct: 2287 QRETLGDTERDDSVLARQLAYWRDALAGLPDELNLPVDRPRPAVPSHRGDRVEFTVDAKL 2346 Query: 264 FSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG-ALGYFGNT 322 +R+ + AR + FMVL AA L+ R +D + PV R A +GYF NT Sbjct: 2347 HARLAELARAHGVTVFMVLQAALATLLTRLGAGTDIPIGSPVAGRDDEATNDVVGYFVNT 2406 Query: 323 LLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGF 382 L+LR T TF + VR T LA +AHQ V + +V PER V L F Sbjct: 2407 LVLRTDTEGNPTFAELLARVRRTNLAAYAHQDVPFELLVDAVQPERSLARHPLFQVMLAF 2466 Query: 383 NMRKSA----GGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD---VSVEFEYQQQLSS 435 N +A G+ V + +A L A + SVEF Sbjct: 2467 NSTDHEVPPESAMADSGLTVTPVRTPTTSAKFDLLFGFAEEESGGLVCSVEFS-TDLFDR 2525 Query: 436 VLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 VD M+ +++ A+ P+ + D+L A ER +L+ + + + ++ Sbjct: 2526 ATVDDMIARLSRVLRTAVTAPDLSIGGYDVLAADERHRLLSGWNDTDRDTSGRSPIELFE 2585 Query: 496 XXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIV 555 S + LTY+EL+ RA+RLA G G E ++ + + + + +V Sbjct: 2586 DQVRRTPDAVAVC--SGDVRLTYAELNTRADRLAAVLCALGVGTERLVAVALPRTEQLVV 2643 Query: 556 AMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG----------RPELD--VAERA 603 A+LA+LKAG AYLP+D YP ER+ YL DARP ++ PE+ + + A Sbjct: 2644 ALLAILKAGGAYLPVDADYPAERLAYLFADARPALLLSSRSQVERLAVEPEIPTLLLDEA 2703 Query: 604 AADNSDLPLSD-SDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTM 662 + D S+ ++R R L+YVIYTSGSTGRPKGV VS ++A ++ AE+ Sbjct: 2704 TVEPVDPQQSEPNERDRAAALDRLSYVIYTSGSTGRPKGVGVSARSMANLLEWARAEFGA 2763 Query: 663 TAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLIS----RRGVTV 718 A R + +S++FD S+ ++F L G G + V DL++ RG + Sbjct: 2764 DAFTRVIFATSLNFDVSVFELFGPLVSG-----------GTVEIVDDLLALLDRPRGWSA 2812 Query: 719 XXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYF-DAELRNHYGPTEAV 777 + + + GEALP + D + N YGPTEA Sbjct: 2813 GMLSAVPSAFARLLAAGALDAHIGLIVLAGEALPSTLVDDIRRRLPTTRVVNAYGPTEAT 2872 Query: 778 VCSTHMVVTGSHGARV--VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYL 835 V +T A + VPIG N YVLD L PVP V+GELYL GS LARGYL Sbjct: 2873 VYTTWYRDDSRKHAELPQVPIGRGLPNTRLYVLDRYLEPVPVGVVGELYLAGSGLARGYL 2932 Query: 836 GRPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVE 894 RP L+A+RF+A PF PG R+YRTGDLVR G+L +VGRADEQVK+RGFRIE GE+E Sbjct: 2933 RRPGLSAERFVACPFGEPGARMYRTGDLVRWLPSGDLVYVGRADEQVKVRGFRIEPGEIE 2992 Query: 895 SVITTHPAVRHCLVVAEETEAGP-MLAAYLVPAAAQVDLEEIRAHTA--AAVPEYMVPGA 951 + +T V VV E G L AY+VPA + ++E TA + +PEY++P Sbjct: 2993 AALTDISGVAQAAVVVREDVPGDRRLVAYVVPADTGIGIDEHALATALRSRLPEYLIPSV 3052 Query: 952 FAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDS 1011 F ++PE+PM +GKLDR+ALPAPT + T + P T TE+ +C +F+ + G VG D Sbjct: 3053 FVLLPELPMNRNGKLDRKALPAPT-VETESFTGPRTPTEQVLCELFSAVLGVPEVGVHDG 3111 Query: 1012 FFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLA 1071 FF LGG S+L+ +LV Q R G+ ++VR +F+ T AGLAA L D + Sbjct: 3112 FFALGGDSILSIQLVGQAR-RAGLRMSVRDVFEHKTVAGLAAAL------DETSPTGHPQ 3164 Query: 1072 ADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXX 1131 A + D G + + + + W R G EFN + + Sbjct: 3165 ASEAESDGDTGDEGIGE--------VVVTPIMEWLAER-GGEIAEFNQSMVVHTPAGASL 3215 Query: 1132 XXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQL--AVRAIDQDEFDDV----- 1184 H+ALR + +G+ V V++ V +D DD Sbjct: 3216 ERIVATLRAVSDHHDALRMRLSDEDGLWRLFVDGPGGVRVDDLVTVLDGTGLDDEEIRPL 3275 Query: 1185 ---STQLRRHVFTPESGPLLQANLLVLGPDTH-VLLLIVHHIVSDHASLEIVFDDLIVAY 1240 + + R +P G + + G + +LLL+ HH+V D S I+ DL AY Sbjct: 3276 LRDAAESARSRLSPSDGVMTRYVWCDRGAEEQGLLLLVAHHLVVDGVSWRILLGDLARAY 3335 Query: 1241 RARLQHNAPQWDILPI-----QFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVA 1295 P+ +LP+ Q+AD+ + E EL +W L + Sbjct: 3336 ADLDAGRTPR--LLPVGTSFRQWADHLAELASRPER---LDELSHWTRTLRAVEPLADDE 3390 Query: 1296 TDRARPRVLGKRGEVVQFSVPA-ARRAALTQLAE--RNGATEFMLYQAALAVVLHKLGGG 1352 D AR R + ++PA LT L E R G E +L A L+V L + GG Sbjct: 3391 LDPARDTHATARS--FERTLPAEVTGTLLTGLVERFRVGMKEVLL--AGLSVALSRWHGG 3446 Query: 1353 TDIALGSPVAARVE-----PATAQLVGLFANVVVLRTDLS----GDPTLRS-ILVGSRDT 1402 T + R E ++ VG F + + D GD + RS +L + T Sbjct: 3447 TATVVDLEGHGREEHLMPGADLSRTVGWFTTLYPVLLDTGPVDWGDASARSELLTRTLRT 3506 Query: 1403 VLDALA 1408 +ALA Sbjct: 3507 TAEALA 3512 Score = 51.6 bits (122), Expect = 0.001 Identities = 28/67 (41%), Positives = 40/67 (59%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIA 1618 TE+ L + +L + + + +FALGGDSI++I+ QA GL VFEH T+A Sbjct: 3089 TEQVLCELFSAVLGVPEVGVHDGFFALGGDSILSIQLVGQARRAGLRMSVRDVFEHKTVA 3148 Query: 1619 ELAAAVD 1625 LAAA+D Sbjct: 3149 GLAAALD 3155 Score = 46.2 bits (108), Expect = 0.040 Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 9/114 (7%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 E E L + ++L + + + +FALGGDSI++I+ A GL VFEH T+ Sbjct: 6735 EREELLCGLFAQVLGLPEVGITDGFFALGGDSILSIQLVGLARQAGLGLSVRDVFEHQTV 6794 Query: 1618 AELAAA---VDAANGEPVVEADPPPAQEYTPMSA------SGLAPDALAKLSAS 1662 A LA + A PV TP+ A SG A ALA + S Sbjct: 6795 AGLATVARDLPTAGTAPVSREAAVGELPLTPIMAWLHQRDSGSAGSALAGFNQS 6848 Score = 45.1 bits (105), Expect = 0.089 Identities = 32/91 (35%), Positives = 45/91 (49%), Gaps = 3/91 (3%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L + ++L + D+++FALGG S++A K S LG+ +FE T+A Sbjct: 978 EEILCTLFGDVLRVPPPSIDDDFFALGGHSLLASKLVSRVRSTLGVELSLRTLFETRTVA 1037 Query: 1619 ELAAAVDAANGEPVVEAD--PPPAQEYTPMS 1647 LAAA+DAA E P P E P S Sbjct: 1038 ALAAALDAAEREDDTRPALLPRPRPETVPAS 1068 Score = 43.9 bits (102), Expect = 0.20 Identities = 28/84 (33%), Positives = 47/84 (55%), Gaps = 4/84 (4%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L + ++L ++ + D+++FALGG S++A + S LG+ +FE T+A Sbjct: 5685 EEILAELFADVLGVSTVGIDDDFFALGGHSLLATRLVSRVRSTLGVELSLRALFEAPTVA 5744 Query: 1619 ELAAAVDA--ANGEPVVEA-DPPP 1639 L+AA+D A G P + A + PP Sbjct: 5745 GLSAALDGAQATGRPALRAVESPP 5768 Score = 40.8 bits (94), Expect = 1.7 Identities = 46/181 (25%), Positives = 67/181 (37%), Gaps = 26/181 (14%) Query: 170 LLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVG---- 225 LLLV HH+ D SW V +L+ AY P A+ V+V A ++A+ Sbjct: 6954 LLLVAHHLVVDGVSWRVLLPDLAQAYGASTRGTP-AELAPVDVSMREWANALAEHARHPD 7012 Query: 226 ------YWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVED-----FARKC 274 YW E L +P R Q R L L + V + + Sbjct: 7013 TAAERPYWTEVLSGVTPVAD----RALDPTRDVQATARTLSRQLSTDVTEELLTRIPERF 7068 Query: 275 SASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG------ALGYFGNTLLLRIT 328 A VLLA + + R+ G +D ++ V R G LG+F +R+ Sbjct: 7069 RAGINDVLLAGLAMALTRWHGGTDTVIDVEGHGREPRLVGDADLSRTLGWFTTLYPVRLV 7128 Query: 329 T 329 T Sbjct: 7129 T 7129 >tr|O07944|O07944_STRPR Tax_Id=38300 (snbDE)SubName: Full=Pristinamycin I synthase 3 and 4;[Streptomyces pristinaespiralis] Length = 4848 Score = 801 bits (2069), Expect = 0.0 Identities = 555/1470 (37%), Positives = 742/1470 (50%), Gaps = 108/1470 (7%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q R+WFL M+ T NI ++ RL G +D L A+ DV ARH LRT Y ++ Sbjct: 2488 LSFAQYRLWFLHRMEGPGPTYNIPMSLRLTGTLDTAALRAALADVTARHEALRTVYP-ES 2546 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 G P Q DV + D T + +E+ R FDL ELPLR T+ R Sbjct: 2547 GGVPRQHVLHDVRPHFETADTTA-------QTLEADLTRAARRGFDLARELPLRATLFRL 2599 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVEV 212 DE VLLL++HHI D SW +L AY LP+ ++ Sbjct: 2600 AEDEHVLLLLMHHIAGDGWSWPPLARDLGDAYAARLAGRAPDLPPLPVQYADYALWQRDL 2659 Query: 213 LQNSAAPS---VADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP---------LP 260 L + P+ + YWA L PC R + V + Sbjct: 2660 LGDEDDPTSRHARQLAYWAGALDDLPEELQL-------PCDRPRPAVATHRGDTVPFAVD 2712 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 L R+ A + AS FMVL AA+ L+ R+ +D + P+ R+ A L G+F Sbjct: 2713 PDLHQRLNALATEGRASLFMVLQAAFAALLTRHGAGTDIPLGSPIAGRTDDALEDLVGFF 2772 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVR 379 NTL+LR T TF + VRE+ LA +AHQ V +++V + PER V Sbjct: 2773 VNTLVLRTDTSGDPTFRELLQRVRESDLAAYAHQDVPFEKLVEKLRPERSLSRHPLFQVM 2832 Query: 380 LGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDDVSVEFEYQQQL 433 L F A LAL G+ R L +G A L L++ P + EY L Sbjct: 2833 LAFQNSGEAR-LALPGLDARALPVGVGVAKFDLHLSMVELRTGDGRPGGIQAALEYATDL 2891 Query: 434 SSVLVDQMLV-HYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGE-----LVEMPA 487 Q LV L+L+ +P + +++L ER VL + P Sbjct: 2892 FDRTTAQALVDRLLRLLAAVADDPGLTVGRVELLDPAERHRVLQDWNTTPGGDGAARTPV 2951 Query: 488 TTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRM 547 T +++ V D+ LTY+ELH RANRLAR I G GPE I+ LRM Sbjct: 2952 TELLERQAARTPDAVAL-----VHDDGRLTYAELHARANRLARHLITLGAGPEQIVALRM 3006 Query: 548 ANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADN 607 S++ VA+LAVLK GAAYLP+D +YP ERI ++I DARP TV+ R D+ D Sbjct: 3007 PRSLDLYVALLAVLKTGAAYLPVDISYPAERIAFMIEDARPVTVLDRLPDDLGAYRDTD- 3065 Query: 608 SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDR 667 L+D+DR PLRP H AYVI+TSGSTG PK V + H +A + + R Sbjct: 3066 ----LTDADRTAPLRPEHPAYVIHTSGSTGTPKAVVMPHAGLANLLTWHARRFPGGTGVR 3121 Query: 668 WLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVT--VXXXXXXX 725 QF+++ FD S+ +I L +G L VP + +A + + + Sbjct: 3122 TAQFTAIGFDFSVQEILSPLVMGKTLAVPSEEVRHSAELLAGWLETQQINELFAPNLVIE 3181 Query: 726 XXXXXXXXXXXQWRQLRHVPVGGEAL-PGEVADRF-AGYFDAELRNHYGPTEAVVCSTHM 783 L + GGEAL P E F A L N YGP E +TH Sbjct: 3182 ALAEAAAEAGRTLPDLTDILQGGEALAPTERVRAFTAAVPGRRLHNVYGPAETHAVTTHT 3241 Query: 784 VVTG-SHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTA 842 + +H PIG P + YVLD L PVP V GELYL G+ +ARGYL RP TA Sbjct: 3242 LAADPAHWPPSAPIGRPVDHDRVYVLDSALRPVPPGVTGELYLAGAGVARGYLHRPRTTA 3301 Query: 843 QRFIADPF--NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 +RF+ADP+ PG R+YRTGDL R N GELEF GRAD QVKIRGFR+E GEVE+ +T H Sbjct: 3302 ERFVADPYAPRPGARMYRTGDLGRWNTRGELEFAGRADHQVKIRGFRVEPGEVEAALTAH 3361 Query: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 P + V+A G L AY+V A + DL +R H AA +P++MVP A+ + +P+ Sbjct: 3362 PRITQAAVLAH----GDRLVAYVVTTADR-DLTGVREHLAARLPDFMVPTAYVRLEALPL 3416 Query: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL 1020 TV+GKLDR ALPAP A R P T E +C +FA++ G +R G +D+FF LGGHSL Sbjct: 3417 TVNGKLDRAALPAPDAPAAGR--APRTVREEILCGLFAEVLGTERAGIDDNFFDLGGHSL 3474 Query: 1021 LAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK 1080 LA RL+++IR G ++T+R +F+APT AGL RL + Sbjct: 3475 LATRLISRIRTALGAEITLRDLFEAPTVAGLGERLDQA---------------------S 3513 Query: 1081 RARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXX 1140 ARP + RP+RLPLS++Q WF R+ G +NMP+ LR G Sbjct: 3514 GARPALTPAERPERLPLSYAQRRLWFLGRLTGGDPGYNMPVGLRLSGTLDTAALTAALAD 3573 Query: 1141 XXXRHEALRTNFDE-HEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLR---RHVFTPE 1196 RHE LRT F E +G P+Q+V + A+ D + DD++T+L RH F Sbjct: 3574 LVARHETLRTVFPEGDDGSPHQLVLDPGAARPALHPRDTTQ-DDLATELAAAARHCFDLT 3632 Query: 1197 SGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPI 1256 + L+A L L D HVLLL++HHI D SL + DL+ AY AR +AP + LP+ Sbjct: 3633 TELPLRATLFRLAEDEHVLLLLLHHIAGDGWSLAPLARDLVTAYAARRDGHAPDFAPLPV 3692 Query: 1257 QFADYAVWQRNTF--ESNWGQT---ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV 1311 Q+ADY +WQ E++ T + +W+DALAGLP+EI + DR RP RGE V Sbjct: 3693 QYADYTLWQHALLGDENDPDSTISRQSAHWKDALAGLPEEIQLPADRPRPATPAHRGEAV 3752 Query: 1312 QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQ 1371 ++ A L LA GA+ FM+ QAA+A VL + G GTDI LGSP+A R + A Sbjct: 3753 FRTLDADLHRELLHLARTGGASLFMVLQAAVAAVLTRHGAGTDIPLGSPIAGRTDDALDD 3812 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 LVG F N +VLRTD SG+PT R +L R+ L A AHQ++P E+LVE P R+LSR+P Sbjct: 3813 LVGFFVNTLVLRTDTSGNPTFRELLDRVREFDLAAYAHQDVPFEKLVEDAAPGRSLSRHP 3872 Query: 1432 LFQNMLNFRGEDWALVP-RDLTGRGETTVV 1460 LFQ +L + A++ LT R E + Sbjct: 3873 LFQVLLALQNTPEAVLELPGLTARPEVVTL 3902 Score = 702 bits (1811), Expect = 0.0 Identities = 495/1459 (33%), Positives = 701/1459 (48%), Gaps = 71/1459 (4%) Query: 55 QTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDD 114 +T PD T+ + + L G +DED L A ++ RH LR + P Q ++ Sbjct: 28 ETHGPDVYTVQM--VFELRGPLDEDGLRAAAAALLRRHPNLRAGFWQQGVERPVQFVPNE 85 Query: 115 VEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVV 174 V + W D T L E+ ER +E+ + FD +R ++ AD L+L Sbjct: 86 VPLPWHTRDFTALGESDRERAVEAYVTADRAERFDPGAPPLIRFALLGLAADHHKLVLTT 145 Query: 175 HHICWDDDSWEVFFGELSAAYND------LPINDPAAQFLSVEVLQNSAAPSVADVGYWA 228 HH+ D S + EL Y +P P +L+ ++ A A A Sbjct: 146 HHLLLDGWSMPLLVRELFTLYGQRGDDAGMPPVTPYRAYLAHLAGRDDDAARAAWRTALA 205 Query: 229 ETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGV 288 + G A+ + + A + + AR C+ + G Sbjct: 206 DLEEPSLVAGAGAGRGAADGSALPGQIWHEIDAATTAGLTALARSCNITLQHPGAKRLGT 265 Query: 289 LVRRYTGASDFLVSVPVTERSGAAAG---ALGYFGNTLLLRITTRSQDTFTSFVNEVRET 345 R G D + V R G +G F NTL +R+ R +T + V+ Sbjct: 266 AARPQLGRDDVVFGATVAHRPPEIPGIESTIGMFINTLPVRVRVRPAETLGDLLGRVQRE 325 Query: 346 CLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFN---MRKSAGGLALDGVVVRQLG 402 A H+ + + + + D + + + +R A GL L G V Sbjct: 326 QAALIEHRHLSLTDIRSTTGTGELF-DTVVVFENYPLDPAVLRAEARGLRLAGFEVSD-- 382 Query: 403 LGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAE--PERPL 460 A H PLSL +A+ + + +++ + ++L+ L + +AE + P+ Sbjct: 383 ----ATHYPLSL-LAIPGESLRFRLDHRGDVLDEAGARLLLERLDTLLTDIAEHGADLPV 437 Query: 461 SSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSE 520 LD+L A ER VL + + +PA + LTY+E Sbjct: 438 GRLDLLSAAERHQVLEEFND--TGLPAEDATLAALFEAQAARTPDTTALLVGGRSLTYAE 495 Query: 521 LHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERID 580 L+ RANRLAR + G GPE I+ +++ S++ VA+LAVLK GAAYLP+D AYP ERI Sbjct: 496 LNARANRLARHLVTLGAGPEQIVAVKLERSLDLYVALLAVLKTGAAYLPVDTAYPAERIA 555 Query: 581 YLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPK 640 +++ DARP V+ + + + D++DL +D+DR PL P H AYVIYTSGSTG PK Sbjct: 556 FMMDDARPAVVLTGEDTG-QDLSGYDDTDL--TDADRTAPLLPAHPAYVIYTSGSTGTPK 612 Query: 641 GVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDA 700 V + A+ + E A QF+++ FD + +I T G L VP + Sbjct: 613 AVVMPGAALVNLLAWHRREIPGEAGAPVAQFTTIGFDVAAQEILATWLHGKTLAVPSQEV 672 Query: 701 FGDISYVADLISRRGVT--VXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALP--GEVA 756 +A + + V+ LRH+ GEAL V Sbjct: 673 RRSAEQLAAWLDEQHVSELYAPNLVIEALAEAAAEAGRTLPALRHIAQAGEALTLTRTVR 732 Query: 757 DRFAGYFDAELRNHYGPTEA-VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPV 815 + A +L NHYGP E V+ T + + + P+G P YVLD L PV Sbjct: 733 EFAAAVPGRQLHNHYGPAETHVMTGTALPEDPAAWSEHAPLGRPVSGARVYVLDSALRPV 792 Query: 816 PDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLVRRNHCGELEF 873 V GELYL G+ ++RGYL RP LTA+RF+ADP+ +PG R+YRTGDL R N GELEF Sbjct: 793 APGVTGELYLAGAGVSRGYLNRPVLTAERFVADPYAPSPGARMYRTGDLGRWNTRGELEF 852 Query: 874 VGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQVDL 932 GRAD QVKIRGFRIE GE+E+ +T PAV VV E G L AY VPA +D Sbjct: 853 AGRADHQVKIRGFRIEPGEIEAALTDLPAVARAAVVVREDRPGDKRLVAYAVPAGEGLDA 912 Query: 933 EEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERW 992 +R+ A +P++MVP A + +P+T +GKLDR ALPAP T R P + E Sbjct: 913 AAVRSRLARTLPDFMVPAAIVALDALPLTPNGKLDRAALPAPQS-TTAVQRTPRSPREEI 971 Query: 993 ICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA 1052 + ++FA + RVG +D+FF LGGHSLLA RL+++IR G ++T+R +F+APT AGL Sbjct: 972 LTTLFAAVLKLPRVGIDDNFFDLGGHSLLATRLISRIRTVLGAEITLRDLFEAPTVAGLG 1031 Query: 1053 ARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEG 1112 RL + ARP + RP+RLPLSH+Q WF R++G Sbjct: 1032 ERLDQA---------------------SGARPALTPAERPERLPLSHAQRRLWFLGRLDG 1070 Query: 1113 AREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQ-IVHPS-RTVQ 1170 +N+PLALR G RHE LRT + H+G PYQ IV P+ T Sbjct: 1071 PNSTYNIPLALRLSGTLDTAALRAALADLVARHETLRTRYPSHDGEPYQHIVAPADATPA 1130 Query: 1171 LAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLE 1230 L V ++ + + + + L+A L LG D HVLLL++HHI D SL Sbjct: 1131 LTVVHTEEHRLAEQLAEATARPYDLTTELPLRATLFRLGEDEHVLLLLLHHIAGDGWSLA 1190 Query: 1231 IVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDAL 1285 + DL AY AR +AP + LP+Q+ADY +WQR ++ +L +WR AL Sbjct: 1191 PLTRDLAAAYAARRDGHAPGFAPLPVQYADYTLWQRGLLGDADDPTSLQAAQLAHWRQAL 1250 Query: 1286 AGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVV 1345 G P + + D RP V RG V F + A LT LA+ ++ FM+ QAA A + Sbjct: 1251 EGRPAHLELPCDHPRPAVATHRGATVPFHIDAGLHEKLTALAKACDSSLFMVLQAAFAAL 1310 Query: 1346 LHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLD 1405 L + G GTDI +GSPVA R + A LVG F N +VLRTD SGDPT R ++ R L Sbjct: 1311 LTRHGAGTDIPVGSPVAGRTDDALDDLVGFFVNTLVLRTDTSGDPTFRELVARVRQFDLA 1370 Query: 1406 ALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRG-ETTVVPLPV 1464 A HQ++P E+LVE +NP R+L+RNPLFQ +L + ++ DL G + P+ V Sbjct: 1371 AYTHQDMPFEKLVEEVNPERSLARNPLFQVVLALQ----SMPAADLALPGLDVAAEPVRV 1426 Query: 1465 NFEVALLFLAIGMSVTPSG 1483 F L LA+ T G Sbjct: 1427 GFAKFDLGLAVIEEHTADG 1445 Score = 471 bits (1211), Expect = e-130 Identities = 370/1086 (34%), Positives = 507/1086 (46%), Gaps = 79/1086 (7%) Query: 28 EQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTA 84 + S +P + P ER LS QRR+WFL + D N+ V RL+G +D L A Sbjct: 3511 QASGARPALTPAERPERLPLSYAQRRLWFLGRLTGGDPGYNMPVGLRLSGTLDTAALTAA 3570 Query: 85 VNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEF 144 + D+VARH LRT + +G P+Q+ D G R L + E AA Sbjct: 3571 LADLVARHETLRTVFPEGDDGSPHQLVLDP---GAARPALHPRDTTQDDLATELAAAAR- 3626 Query: 145 GRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-------- 196 FDLT ELPLR T+ R DE VLLL++HHI D S +L AY Sbjct: 3627 -HCFDLTTELPLRATLFRLAEDEHVLLLLLHHIAGDGWSLAPLARDLVTAYAARRDGHAP 3685 Query: 197 ---DLPINDPAAQFLSVEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXG--VSGANP 248 LP+ +L + P +W + L A P Sbjct: 3686 DFAPLPVQYADYTLWQHALLGDENDPDSTISRQSAHWKDALAGLPEEIQLPADRPRPATP 3745 Query: 249 CRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTER 308 R + R L A L + AR AS FMVL AA ++ R+ +D + P+ R Sbjct: 3746 AHRGEAVFRTLDADLHRELLHLARTGGASLFMVLQAAVAAVLTRHGAGTDIPLGSPIAGR 3805 Query: 309 SGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPE 367 + A L G+F NTL+LR T TF ++ VRE LA +AHQ V +++V +A P Sbjct: 3806 TDDALDDLVGFFVNTLVLRTDTSGNPTFRELLDRVREFDLAAYAHQDVPFEKLVEDAAPG 3865 Query: 368 RMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPD 421 R V L A L L G+ R + AA L+ +A +P Sbjct: 3866 RSLSRHPLFQVLLALQNTPEAV-LELPGLTARPEVVTLGAAKFDLTFNLAERHGPDGEPH 3924 Query: 422 DVSVEFEYQQQL-----SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA 476 + EY L + L D+ L+ +L+ V A+P R ++ + IL A + VL Sbjct: 3925 GIDAVLEYSTDLFDRTTAEALTDR-LITFLRAV---AADPGRTVADVPILDADDHARVLT 3980 Query: 477 QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAE---LTYSELHRRANRLARWFI 533 + T EA +TYSEL RANRLAR I Sbjct: 3981 GWNDTDHPRGRRTADACLPRRIAEQAARTPHAVAVTEAGGTLITYSELDARANRLARHLI 4040 Query: 534 GQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITD-------- 585 +G E + + S + +V LA+LKAG Y+P+ YP +R+ +++ D Sbjct: 4041 RRGVTAETRVAVLAERSAQLVVTTLAILKAGGVYVPLHTGYPVDRMRHVLADTEAALLLT 4100 Query: 586 ----ARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKG 641 A + P L V E A D D +RP LAY+++TSGSTG PKG Sbjct: 4101 DTHHAATAARLDTPALTVDEDTTAGEQDTTAPDV----TVRPDQLAYIMFTSGSTGTPKG 4156 Query: 642 VAVSHH-AIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIV-PKPD 699 + ++H AIA W + R L S +FD S ++F L G +++V P+ D Sbjct: 4157 IGITHRDAIALAADRC---WDLDTGSRVLMHSPYAFDISTFELFAPLLAGGRIVVAPRGD 4213 Query: 700 AFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEAL-PGEVADR 758 D + + ++ GVT + ++ V GG+ + P V Sbjct: 4214 I--DAAVLQRTLAAHGVT-SLLLTAGLLGVIADEAPEVFTGVKDVWTGGDVVSPTAVRRV 4270 Query: 759 FAGYFDAELRNHYGPTEAVVCSTHMVVTGSHG-ARVVPIGVPNRNVYAYVLDEQLHPVPD 817 ++ YGPTE + T + T VPIG P N AYVLDE+L PVP Sbjct: 4271 LEACPGTVVKTLYGPTETTLGCTWLPFTDPRRIPPAVPIGRPLDNTRAYVLDERLRPVPP 4330 Query: 818 QVIGELYLGGSQLARGYLGRPTLTAQRFIADPF-----NPGMRLYRTGDLVRRNHCGELE 872 V GELY+ G+ LARGY + TA+RF ADP + G R+YRTGDL RR+ G L Sbjct: 4331 GVTGELYIAGAGLARGYWDQSARTAERFTADPHAHLFGDTGGRMYRTGDLARRDADGVLH 4390 Query: 873 FVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLV--PAAAQ 929 F GRAD+QVKIRGFRIE GE+E+ + HP V VVA AG +L AYLV P A Sbjct: 4391 FCGRADQQVKIRGFRIEPGEIETALAAHPDVTRAAVVARPGRAGDKVLVAYLVTAPDAGD 4450 Query: 930 VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETAT 989 E++RA +P+YMVP AF +P +P+T +GKLDR ALP P R P Sbjct: 4451 TTAEQLRAGLETQLPDYMVPAAFVALPALPVTPNGKLDRDALPEP-DWGGGAGRPPRGPR 4509 Query: 990 ERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPA 1049 E +C +FA++ G RVG +D+FF LGGHS+LA RLV +++ G D+ VRT+F+APT A Sbjct: 4510 EEILCGLFAEVLGAPRVGTDDNFFELGGHSMLATRLVGRVKTVLGADIGVRTLFEAPTVA 4569 Query: 1050 GLAARL 1055 LAAR+ Sbjct: 4570 ALAARI 4575 Score = 468 bits (1204), Expect = e-129 Identities = 344/940 (36%), Positives = 469/940 (49%), Gaps = 74/940 (7%) Query: 28 EQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTA 84 + S +P + P ER LS QRR+WFL +D + T NI +A RL+G +D L A Sbjct: 1036 QASGARPALTPAERPERLPLSHAQRRLWFLGRLDGPNSTYNIPLALRLSGTLDTAALRAA 1095 Query: 85 VNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGH--ERQIESLAAD 142 + D+VARH LRT Y +GEPYQ D T H E ++ A+ Sbjct: 1096 LADLVARHETLRTRYP-SHDGEPYQHIVAPA-------DATPALTVVHTEEHRLAEQLAE 1147 Query: 143 EFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN------ 196 RP+DLT ELPLR T+ R DE VLLL++HHI D S +L+AAY Sbjct: 1148 ATARPYDLTTELPLRATLFRLGEDEHVLLLLLHHIAGDGWSLAPLTRDLAAAYAARRDGH 1207 Query: 197 -----DLPINDPAAQFLSVEVLQNSAAPS---VADVGYWAETL--RXXXXXXXXXGVSGA 246 LP+ +L ++ P+ A + +W + L R A Sbjct: 1208 APGFAPLPVQYADYTLWQRGLLGDADDPTSLQAAQLAHWRQALEGRPAHLELPCDHPRPA 1267 Query: 247 NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVT 306 R + AGL ++ A+ C +S FMVL AA+ L+ R+ +D V PV Sbjct: 1268 VATHRGATVPFHIDAGLHEKLTALAKACDSSLFMVLQAAFAALLTRHGAGTDIPVGSPVA 1327 Query: 307 ERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREAN 365 R+ A L G+F NTL+LR T TF V VR+ LA + HQ + +++V E N Sbjct: 1328 GRTDDALDDLVGFFVNTLVLRTDTSGDPTFRELVARVRQFDLAAYTHQDMPFEKLVEEVN 1387 Query: 366 PER-MGRDGMDLLVRLGFNMRKSAGGLALDGVVVR-----------QLGLGAVAAHLPLS 413 PER + R+ + +V +M A LAL G+ V LGL + H Sbjct: 1388 PERSLARNPLFQVVLALQSM--PAADLALPGLDVAAEPVRVGFAKFDLGLAVIEEHTADG 1445 Query: 414 LTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERD 472 + D +EY +L V+ + ++L+D +PER + S+D+L A ER Sbjct: 1446 TRAGIRGD-----WEYSTELFERGTVEALGSRLVRLLDAVADDPERTIGSVDLLDATERH 1500 Query: 473 SVLA---QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLA 529 +L + G L E T + V + LTY+EL RANRLA Sbjct: 1501 RLLVGLNTTDGPLPEERTLTAL----FEQQAAATPDATALVMGDRSLTYAELDARANRLA 1556 Query: 530 RWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQ 589 R + G GPE I+ L++ S++ + A+LAV K+GAAYLP+DP YP ERI ++ DARP Sbjct: 1557 RHLVALGAGPEQIVALQLPRSLDLVTAVLAVWKSGAAYLPVDPDYPPERIAHMRADARPA 1616 Query: 590 TVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAI 649 V+ D A AD+ L+D+DR PL P H AYVIYTSGSTG PKGV V+H ++ Sbjct: 1617 LVVDAIPDDTTLAAYADSR---LTDADRSAPLLPAHPAYVIYTSGSTGAPKGVVVAHRSL 1673 Query: 650 AEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVAD 709 A V A + + R L F+S+SFDA++ ++ LF GA L++ D +A Sbjct: 1674 AATVPAQAAAFGLGTHSRVLNFASISFDAAVWELTSALFTGAGLVLADADDLLPGPSLAR 1733 Query: 710 LISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRN 769 L+ R +T+ + V G+A + A RFA + N Sbjct: 1734 LVHDRHITLIALPPSALPALPDGALPPG----TDLIVAGDATAPDQAARFAP--GRRMVN 1787 Query: 770 HYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQ 829 YG TE VC+T GA PIG P + YVLDE+L PVP V GE+Y+ G+ Sbjct: 1788 AYGLTETTVCATMSEPATGDGA--PPIGRPVAHARVYVLDERLRPVPPGVTGEMYVSGAG 1845 Query: 830 LARGYLGRPTLTAQRFIADPF-----NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIR 884 +ARGYL RP LTAQRF+ DP+ G R+YRTGDL R + G L F GRAD+QVKIR Sbjct: 1846 VARGYLHRPALTAQRFVPDPYALLFGETGTRMYRTGDLARLDADGRLHFAGRADQQVKIR 1905 Query: 885 GFRIELGEVESVITTHPAVRHCLVVA-EETEAGPMLAAYL 923 GFRIE GE+E+V+T HPAV V+A E+T L AYL Sbjct: 1906 GFRIEPGEIETVLTAHPAVAAGAVIAREDTPGDKQLVAYL 1945 Score = 344 bits (883), Expect = 5e-92 Identities = 224/570 (39%), Positives = 297/570 (52%), Gaps = 38/570 (6%) Query: 925 PAAAQVD---LEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRR 981 PA A+ D + E+R A +P +M P A+ ++ +P++ +GKLDR ALPAP Sbjct: 2334 PARAEQDAALVGELRDLVAQRLPAHMAPAAYVLLDRLPLSANGKLDRDALPAPDRGEDAA 2393 Query: 982 YREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRT 1041 + P T E + ++FA++ G VG + SFF LGGHSLLA RL+++IR+ G +L VR Sbjct: 2394 GQAPRTRREEILSTLFAEVLGLPAVGIDRSFFDLGGHSLLATRLLSRIRSVLGAELAVRD 2453 Query: 1042 IFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQ 1101 +F APT A LA R+ + ARP RP +PLS +Q Sbjct: 2454 LFQAPTVAALAERVD---------------------GAQEARPPLTARTRPAEVPLSFAQ 2492 Query: 1102 LAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQ 1161 WF +R+EG +N+P++LR G RHEALRT + E GVP Q Sbjct: 2493 YRLWFLHRMEGPGPTYNIPMSLRLTGTLDTAALRAALADVTARHEALRTVYPESGGVPRQ 2552 Query: 1162 -IVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVH 1220 ++H R Q D++ RR PL +A L L D HVLLL++H Sbjct: 2553 HVLHDVRPHFETADTTAQTLEADLTRAARRGFDLARELPL-RATLFRLAEDEHVLLLLMH 2611 Query: 1221 HIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT---- 1276 HI D S + DL AY ARL AP LP+Q+ADYA+WQR+ T Sbjct: 2612 HIAGDGWSWPPLARDLGDAYAARLAGRAPDLPPLPVQYADYALWQRDLLGDEDDPTSRHA 2671 Query: 1277 -ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEF 1335 +L YW AL LP+E+ + DR RP V RG+ V F+V L LA A+ F Sbjct: 2672 RQLAYWAGALDDLPEELQLPCDRPRPAVATHRGDTVPFAVDPDLHQRLNALATEGRASLF 2731 Query: 1336 MLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSI 1395 M+ QAA A +L + G GTDI LGSP+A R + A LVG F N +VLRTD SGDPT R + Sbjct: 2732 MVLQAAFAALLTRHGAGTDIPLGSPIAGRTDDALEDLVGFFVNTLVLRTDTSGDPTFREL 2791 Query: 1396 LVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWA-LVPRDLTGR 1454 L R++ L A AHQ++P E+LVE L P R+LSR+PLFQ ML F+ A L L R Sbjct: 2792 LQRVRESDLAAYAHQDVPFEKLVEKLRPERSLSRHPLFQVMLAFQNSGEARLALPGLDAR 2851 Query: 1455 GETTVVPLPVNFEVALLFLAIGMSVTPSGE 1484 LPV VA L + M +G+ Sbjct: 2852 A------LPVGVGVAKFDLHLSMVELRTGD 2875 Score = 38.9 bits (89), Expect = 6.4 Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 1/70 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQA-GALGLPFPPAMVFEHMTIA 1618 E L + E+L + D+N+F LGG S++A + + LG +FE T+A Sbjct: 4510 EEILCGLFAEVLGAPRVGTDDNFFELGGHSMLATRLVGRVKTVLGADIGVRTLFEAPTVA 4569 Query: 1619 ELAAAVDAAN 1628 LAA +D A+ Sbjct: 4570 ALAARIDGAD 4579 >tr|D0RB84|D0RB84_STRPR Tax_Id=38300 (snbDE)SubName: Full=Putative pristinamycin I peptide synthase 3 and 4;[Streptomyces pristinaespiralis] Length = 4848 Score = 800 bits (2067), Expect = 0.0 Identities = 555/1470 (37%), Positives = 742/1470 (50%), Gaps = 108/1470 (7%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q R+WFL M+ T NI ++ RL G +D L A+ DV ARH LRT Y ++ Sbjct: 2488 LSFAQYRLWFLHRMEGFGPTYNIPMSLRLTGTLDTAALRAALADVTARHEALRTVYP-ES 2546 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 G P Q DV + D T + +E+ R FDL ELPLR T+ R Sbjct: 2547 GGVPRQHVLHDVRPHFETADTTA-------QTLEADLTRAARRGFDLARELPLRATLFRL 2599 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVEV 212 DE VLLL++HHI D SW +L AY LP+ ++ Sbjct: 2600 AEDEHVLLLLMHHIAGDGWSWPPLARDLGDAYAARLAGRAPDLPPLPVQYADYALWQRDL 2659 Query: 213 LQNSAAPS---VADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP---------LP 260 L + P+ + YWA L PC R + V + Sbjct: 2660 LGDEDDPTSRHARQLAYWAGALDDLPEELQL-------PCDRPRPAVATHRGDTVPFAVD 2712 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 L R+ A + AS FMVL AA+ L+ R+ +D + P+ R+ A L G+F Sbjct: 2713 PDLHQRLNALATEGRASLFMVLQAAFAALLTRHGAGTDIPLGSPIAGRTDDALEDLVGFF 2772 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVR 379 NTL+LR T TF + VRE+ LA +AHQ V +++V + PER V Sbjct: 2773 VNTLVLRTDTSGDPTFRELLQRVRESDLAAYAHQDVPFEKLVEKLRPERSLSRHPLFQVM 2832 Query: 380 LGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDDVSVEFEYQQQL 433 L F A LAL G+ R L +G A L L++ P + EY L Sbjct: 2833 LAFQNSGEAR-LALPGLDARALPVGVGVAKFDLHLSMVELRTGDGRPGGIQAALEYATDL 2891 Query: 434 SSVLVDQMLV-HYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGE-----LVEMPA 487 Q LV L+L+ +P + +++L ER VL + P Sbjct: 2892 FDRTTAQALVDRLLRLLAAVADDPGLTVGRVELLDPAERHRVLQDWNTTPGGDGAARTPV 2951 Query: 488 TTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRM 547 T +++ V D+ LTY+ELH RANRLAR I G GPE I+ LRM Sbjct: 2952 TELLERQAARTPDAVAL-----VHDDGRLTYAELHARANRLARHLITLGAGPEQIVALRM 3006 Query: 548 ANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADN 607 S++ VA+LAVLK GAAYLP+D +YP ERI ++I DARP TV+ R D+ D Sbjct: 3007 PRSLDLYVALLAVLKTGAAYLPVDISYPAERIAFMIEDARPVTVLDRLPDDLGAYRDTD- 3065 Query: 608 SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDR 667 L+D+DR PLRP H AYVI+TSGSTG PK V + H +A + + R Sbjct: 3066 ----LTDADRTAPLRPEHPAYVIHTSGSTGTPKAVVMPHAGLANLLTWHARRFPGGTGVR 3121 Query: 668 WLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVT--VXXXXXXX 725 QF+++ FD S+ +I L +G L VP + +A + + + Sbjct: 3122 TAQFTAIGFDFSVQEILSPLVMGKTLAVPSEEVRHSAELLAGWLETQQINELFAPNLVIE 3181 Query: 726 XXXXXXXXXXXQWRQLRHVPVGGEAL-PGEVADRF-AGYFDAELRNHYGPTEAVVCSTHM 783 L + GGEAL P E F A L N YGP E +TH Sbjct: 3182 ALAEAAAEAGRTLPDLTDILQGGEALAPTERVRAFTAAVPGRRLHNVYGPAETHAVTTHT 3241 Query: 784 VVTG-SHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTA 842 + +H PIG P + YVLD L PVP V GELYL G+ +ARGYL RP TA Sbjct: 3242 LAADPAHWPPSAPIGRPVDHDRVYVLDSALRPVPPGVTGELYLAGAGVARGYLHRPRTTA 3301 Query: 843 QRFIADPF--NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 +RF+ADP+ PG R+YRTGDL R N GELEF GRAD QVKIRGFR+E GEVE+ +T H Sbjct: 3302 ERFVADPYAPRPGARMYRTGDLGRWNTRGELEFAGRADHQVKIRGFRVEPGEVEAALTAH 3361 Query: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 P + V+A G L AY+V A + DL +R H AA +P++MVP A+ + +P+ Sbjct: 3362 PRITQAAVLAH----GDRLVAYVVTTADR-DLTGVREHLAARLPDFMVPTAYVRLEALPL 3416 Query: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL 1020 TV+GKLDR ALPAP A R P T E +C +FA++ G +R G +D+FF LGGHSL Sbjct: 3417 TVNGKLDRAALPAPDAPAAGR--APRTVREEILCGLFAEVLGTERAGIDDNFFDLGGHSL 3474 Query: 1021 LAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK 1080 LA RL+++IR G ++T+R +F+APT AGL RL + Sbjct: 3475 LATRLISRIRTALGAEITLRDLFEAPTVAGLGERLDQA---------------------S 3513 Query: 1081 RARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXX 1140 ARP + RP+RLPLS++Q WF R+ G +NMP+ LR G Sbjct: 3514 GARPALTPAERPERLPLSYAQRRLWFLGRLTGGDPGYNMPVGLRLSGTLDTAALTAALAD 3573 Query: 1141 XXXRHEALRTNFDE-HEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLR---RHVFTPE 1196 RHE LRT F E +G P+Q+V + A+ D + DD++T+L RH F Sbjct: 3574 LVARHETLRTVFPEGDDGSPHQLVLDPGAARPALHPRDTTQ-DDLATELAAAARHCFDLT 3632 Query: 1197 SGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPI 1256 + L+A L L D HVLLL++HHI D SL + DL+ AY AR +AP + LP+ Sbjct: 3633 TELPLRATLFRLAEDEHVLLLLLHHIAGDGWSLAPLARDLVTAYAARRDGHAPDFAPLPV 3692 Query: 1257 QFADYAVWQRNTF--ESNWGQT---ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV 1311 Q+ADY +WQ E++ T + +W+DALAGLP+EI + DR RP RGE V Sbjct: 3693 QYADYTLWQHALLGDENDPDSTISRQSAHWKDALAGLPEEIQLPADRPRPATPAHRGEAV 3752 Query: 1312 QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQ 1371 ++ A L LA GA+ FM+ QAA+A VL + G GTDI LGSP+A R + A Sbjct: 3753 FRTLDADLHRELLHLARTGGASLFMVLQAAVAAVLTRHGAGTDIPLGSPIAGRTDDALDD 3812 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 LVG F N +VLRTD SG+PT R +L R+ L A AHQ++P E+LVE P R+LSR+P Sbjct: 3813 LVGFFVNTLVLRTDTSGNPTFRELLDRVREFDLAAYAHQDVPFEKLVEDAAPGRSLSRHP 3872 Query: 1432 LFQNMLNFRGEDWALVP-RDLTGRGETTVV 1460 LFQ +L + A++ LT R E + Sbjct: 3873 LFQVLLALQNTPEAVLELPGLTARPEVVTL 3902 Score = 709 bits (1830), Expect = 0.0 Identities = 496/1459 (33%), Positives = 708/1459 (48%), Gaps = 71/1459 (4%) Query: 55 QTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDD 114 +T PD T+ + + L G +DED L A ++ RH LR + P Q ++ Sbjct: 28 ETHGPDVYTVQM--VFELRGPLDEDGLRAAAAALLRRHPNLRAGFWQQGVERPVQFVPNE 85 Query: 115 VEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVV 174 V + W D T L E+ ER +E+ + FD +R ++ AD L+L Sbjct: 86 VPLPWHTRDFTALGESDRERAVEAYVTADRAERFDPGAPPLIRFALLGLAADHHKLVLTT 145 Query: 175 HHICWDDDSWEVFFGELSAAYND------LPINDPAAQFLSVEVLQNSAAPSVADVGYWA 228 HH+ D S + EL Y +P P +L+ ++ A A A Sbjct: 146 HHLLLDGWSMPLLVRELFTLYGQRGDDAGMPPVTPYRAYLAHLAGRDDDAARAAWRTALA 205 Query: 229 ETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGV 288 + G A+ + + A + + AR C+ + ++ +A+ + Sbjct: 206 DLEEPSLVAGAGAGRGAADGSALPGQIWHEIDAATTAGLTALARSCNITLNTLVQSAWAL 265 Query: 289 LVRRYTGASDFLVSVPVTERSGAAAG---ALGYFGNTLLLRITTRSQDTFTSFVNEVRET 345 L+ R G D + V R G +G F NTL +R+ R +T + V+ Sbjct: 266 LLGRQLGRDDVVFGATVAHRPPEIPGIESTIGMFINTLPVRVRVRPAETLGDLLGRVQRE 325 Query: 346 CLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFN---MRKSAGGLALDGVVVRQLG 402 A H+ + + + + D + + + +R A GL L G V Sbjct: 326 QAALIEHRHLSLTDIRSTTGTGELF-DTVVVFENYPLDPAVLRAEARGLRLAGFEVSD-- 382 Query: 403 LGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAE--PERPL 460 A H PLSL +A+ + + +++ + ++L+ L + +AE + P+ Sbjct: 383 ----ATHYPLSL-LAIPGESLRFRLDHRGDVLDEAGARLLLERLDTLLTDIAEHGADLPV 437 Query: 461 SSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSE 520 LD+L A ER VL + + +PA + LTY+E Sbjct: 438 GRLDLLSAAERHQVLEEFND--TGLPAEDATLAALFEAQAARTPDTTALLVGGRSLTYAE 495 Query: 521 LHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERID 580 L+ RANRLAR + G GPE I+ +++ S++ VA+LAVLK GAAYLP+D AYP ERI Sbjct: 496 LNARANRLARHLVTLGAGPEQIVAVKLERSLDLYVALLAVLKTGAAYLPVDTAYPAERIA 555 Query: 581 YLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPK 640 +++ DARP V+ + + + D++DL +D+DR PL P H AYVIYTSGSTG PK Sbjct: 556 FMMDDARPAVVLTGEDTG-QDLSGYDDTDL--TDADRTAPLLPAHPAYVIYTSGSTGTPK 612 Query: 641 GVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDA 700 V + A+ + E A QF+++ FD + +I T G L VP + Sbjct: 613 AVVMPGAALVNLLAWHRREIPGEAGAPVAQFTTIGFDVAAQEILATWLHGKTLAVPSQEV 672 Query: 701 FGDISYVADLISRRGVT--VXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALP--GEVA 756 +A + + V+ LRH+ GEAL V Sbjct: 673 RRSAEQLAAWLDEQHVSELYAPNLVIEALAEAAAEAGRTLPALRHIAQAGEALTLTRTVR 732 Query: 757 DRFAGYFDAELRNHYGPTEA-VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPV 815 + A +L NHYGP E V+ T + + + P+G P YVLD L PV Sbjct: 733 EFAAAVPGRQLHNHYGPAETHVMTGTALPEDPAAWSEHAPLGRPVSGARVYVLDSALRPV 792 Query: 816 PDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLVRRNHCGELEF 873 V GELYL G+ ++RGYL RP LTA+RF+ADP+ +PG R+YRTGDL R N GELEF Sbjct: 793 APGVTGELYLAGAGVSRGYLNRPVLTAERFVADPYAPSPGARMYRTGDLGRWNTRGELEF 852 Query: 874 VGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQVDL 932 GRAD QVKIRGFRIE GE+E+ +T PAV VV E G L AY VPA +D Sbjct: 853 AGRADHQVKIRGFRIEPGEIEAALTDLPAVARAAVVVREDRPGDKRLVAYAVPAGEGLDA 912 Query: 933 EEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERW 992 +R+ A +P++MVP A + +P+T +GKLDR ALPAP T R P + E Sbjct: 913 AAVRSRLARTLPDFMVPAAIVALDALPLTPNGKLDRAALPAPQS-TTAVQRTPRSPREEI 971 Query: 993 ICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA 1052 + ++FA + RVG +D+FF LGGHSLLA RL+++IR G ++T+R +F+APT AGL Sbjct: 972 LTTLFAAVLKLPRVGIDDNFFDLGGHSLLATRLISRIRTVLGAEITLRDLFEAPTVAGLG 1031 Query: 1053 ARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEG 1112 RL + ARP + RP+RLPLSH+Q WF R++G Sbjct: 1032 ERLDQA---------------------SGARPALTPAERPERLPLSHAQRRLWFLGRLDG 1070 Query: 1113 AREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQ-IVHPS-RTVQ 1170 +N+PLALR G RHE LRT + H+G PYQ IV P+ T Sbjct: 1071 PNSTYNIPLALRLSGTLDTAALRAALADLVARHETLRTRYPSHDGEPYQHIVAPADATPA 1130 Query: 1171 LAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLE 1230 L V ++ + + + + L+A L LG D HVLLL++HHI D SL Sbjct: 1131 LTVVHTEEHRLAEQLAEATARPYDLTTELPLRATLFRLGEDEHVLLLLLHHIAGDGWSLA 1190 Query: 1231 IVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDAL 1285 + DL AY AR +AP + LP+Q+ADY +WQR ++ +L +WR AL Sbjct: 1191 PLTRDLAAAYAARRDGHAPGFAPLPVQYADYTLWQRGLLGDADDPTSLQAAQLAHWRQAL 1250 Query: 1286 AGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVV 1345 G P + + D RP V RG V F + A LT LA+ ++ FM+ QAA A + Sbjct: 1251 EGRPAHLELPCDHPRPAVATHRGATVPFHIDAGLHEKLTALAKACDSSLFMVLQAAFAAL 1310 Query: 1346 LHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLD 1405 L + G GTDI +GSPVA R + A LVG F N +VLRTD SGDPT R ++ R L Sbjct: 1311 LTRHGAGTDIPVGSPVAGRTDDALDDLVGFFVNTLVLRTDTSGDPTFRELVARVRQFDLA 1370 Query: 1406 ALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRG-ETTVVPLPV 1464 A HQ++P E+LVE +NP R+L+RNPLFQ +L + ++ DL G + P+ V Sbjct: 1371 AYTHQDMPFEKLVEEVNPERSLARNPLFQVVLALQ----SMPAADLALPGLDVAAEPVRV 1426 Query: 1465 NFEVALLFLAIGMSVTPSG 1483 F L LA+ T G Sbjct: 1427 GFAKFDLGLAVIEEHTADG 1445 Score = 471 bits (1211), Expect = e-130 Identities = 370/1086 (34%), Positives = 507/1086 (46%), Gaps = 79/1086 (7%) Query: 28 EQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTA 84 + S +P + P ER LS QRR+WFL + D N+ V RL+G +D L A Sbjct: 3511 QASGARPALTPAERPERLPLSYAQRRLWFLGRLTGGDPGYNMPVGLRLSGTLDTAALTAA 3570 Query: 85 VNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEF 144 + D+VARH LRT + +G P+Q+ D G R L + E AA Sbjct: 3571 LADLVARHETLRTVFPEGDDGSPHQLVLDP---GAARPALHPRDTTQDDLATELAAAAR- 3626 Query: 145 GRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-------- 196 FDLT ELPLR T+ R DE VLLL++HHI D S +L AY Sbjct: 3627 -HCFDLTTELPLRATLFRLAEDEHVLLLLLHHIAGDGWSLAPLARDLVTAYAARRDGHAP 3685 Query: 197 ---DLPINDPAAQFLSVEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXG--VSGANP 248 LP+ +L + P +W + L A P Sbjct: 3686 DFAPLPVQYADYTLWQHALLGDENDPDSTISRQSAHWKDALAGLPEEIQLPADRPRPATP 3745 Query: 249 CRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTER 308 R + R L A L + AR AS FMVL AA ++ R+ +D + P+ R Sbjct: 3746 AHRGEAVFRTLDADLHRELLHLARTGGASLFMVLQAAVAAVLTRHGAGTDIPLGSPIAGR 3805 Query: 309 SGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPE 367 + A L G+F NTL+LR T TF ++ VRE LA +AHQ V +++V +A P Sbjct: 3806 TDDALDDLVGFFVNTLVLRTDTSGNPTFRELLDRVREFDLAAYAHQDVPFEKLVEDAAPG 3865 Query: 368 RMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPD 421 R V L A L L G+ R + AA L+ +A +P Sbjct: 3866 RSLSRHPLFQVLLALQNTPEAV-LELPGLTARPEVVTLGAAKFDLTFNLAERHGPDGEPH 3924 Query: 422 DVSVEFEYQQQL-----SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA 476 + EY L + L D+ L+ +L+ V A+P R ++ + IL A + VL Sbjct: 3925 GIDAVLEYSTDLFDRTTAEALTDR-LITFLRAV---AADPGRTVADVPILDADDHARVLT 3980 Query: 477 QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAE---LTYSELHRRANRLARWFI 533 + T EA +TYSEL RANRLAR I Sbjct: 3981 GWNDTDHPRGRRTADACLPRRIAEQAARTPHAVAVTEAGGTLITYSELDARANRLARHLI 4040 Query: 534 GQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITD-------- 585 +G E + + S + +V LA+LKAG Y+P+ YP +R+ +++ D Sbjct: 4041 RRGVTAETRVAVLAERSAQLVVTTLAILKAGGVYVPLHTGYPVDRMRHVLADTEAALLLT 4100 Query: 586 ----ARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKG 641 A + P L V E A D D +RP LAY+++TSGSTG PKG Sbjct: 4101 DTHHAATAARLDTPALTVDEDTTAGEQDTTAPDV----TVRPDQLAYIMFTSGSTGTPKG 4156 Query: 642 VAVSHH-AIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIV-PKPD 699 + ++H AIA W + R L S +FD S ++F L G +++V P+ D Sbjct: 4157 IGITHRDAIALAADRC---WDLDTGSRVLMHSPYAFDISTFELFAPLLAGGRIVVAPRGD 4213 Query: 700 AFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEAL-PGEVADR 758 D + + ++ GVT + ++ V GG+ + P V Sbjct: 4214 I--DAAVLQRTLAAHGVT-SLLLTAGLLGVIADEAPEVFTGVKDVWTGGDVVSPTAVRRV 4270 Query: 759 FAGYFDAELRNHYGPTEAVVCSTHMVVTGSHG-ARVVPIGVPNRNVYAYVLDEQLHPVPD 817 ++ YGPTE + T + T VPIG P N AYVLDE+L PVP Sbjct: 4271 LEACPGTVVKTLYGPTETTLGCTWLPFTDPRRIPPAVPIGRPLDNTRAYVLDERLRPVPP 4330 Query: 818 QVIGELYLGGSQLARGYLGRPTLTAQRFIADPF-----NPGMRLYRTGDLVRRNHCGELE 872 V GELY+ G+ LARGY + TA+RF ADP + G R+YRTGDL RR+ G L Sbjct: 4331 GVTGELYIAGAGLARGYWDQSARTAERFTADPHAHLFGDTGGRMYRTGDLARRDADGVLH 4390 Query: 873 FVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLV--PAAAQ 929 F GRAD+QVKIRGFRIE GE+E+ + HP V VVA AG +L AYLV P A Sbjct: 4391 FCGRADQQVKIRGFRIEPGEIETALAAHPDVTRAAVVARPGRAGDKVLVAYLVTAPDAGD 4450 Query: 930 VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETAT 989 E++RA +P+YMVP AF +P +P+T +GKLDR ALP P R P Sbjct: 4451 TTAEQLRAGLETQLPDYMVPAAFVALPALPVTPNGKLDRDALPEP-DWGGGAGRPPRGPR 4509 Query: 990 ERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPA 1049 E +C +FA++ G RVG +D+FF LGGHS+LA RLV +++ G D+ VRT+F+APT A Sbjct: 4510 EEILCGLFAEVLGAPRVGTDDNFFELGGHSMLATRLVGRVKTVLGADIGVRTLFEAPTVA 4569 Query: 1050 GLAARL 1055 LAAR+ Sbjct: 4570 ALAARI 4575 Score = 466 bits (1198), Expect = e-128 Identities = 343/940 (36%), Positives = 468/940 (49%), Gaps = 74/940 (7%) Query: 28 EQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTA 84 + S +P + P ER LS QRR+WFL +D + T NI +A RL+G +D L A Sbjct: 1036 QASGARPALTPAERPERLPLSHAQRRLWFLGRLDGPNSTYNIPLALRLSGTLDTAALRAA 1095 Query: 85 VNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGH--ERQIESLAAD 142 + D+VARH LRT Y +GEPYQ D T H E ++ A+ Sbjct: 1096 LADLVARHETLRTRYP-SHDGEPYQHIVAPA-------DATPALTVVHTEEHRLAEQLAE 1147 Query: 143 EFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN------ 196 RP+DLT ELPLR T+ R DE VLLL++HHI D S +L+AAY Sbjct: 1148 ATARPYDLTTELPLRATLFRLGEDEHVLLLLLHHIAGDGWSLAPLTRDLAAAYAARRDGH 1207 Query: 197 -----DLPINDPAAQFLSVEVLQNSAAPS---VADVGYWAETL--RXXXXXXXXXGVSGA 246 LP+ +L ++ P+ A + +W + L R A Sbjct: 1208 APGFAPLPVQYADYTLWQRGLLGDADDPTSLQAAQLAHWRQALEGRPAHLELPCDHPRPA 1267 Query: 247 NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVT 306 R + AGL ++ A+ C +S FMVL AA+ L+ R+ +D V PV Sbjct: 1268 VATHRGATVPFHIDAGLHEKLTALAKACDSSLFMVLQAAFAALLTRHGAGTDIPVGSPVA 1327 Query: 307 ERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREAN 365 R+ A L G+F NTL+LR T TF V VR+ LA + HQ + +++V E N Sbjct: 1328 GRTDDALDDLVGFFVNTLVLRTDTSGDPTFRELVARVRQFDLAAYTHQDMPFEKLVEEVN 1387 Query: 366 PER-MGRDGMDLLVRLGFNMRKSAGGLALDGVVVR-----------QLGLGAVAAHLPLS 413 PER + R+ + +V +M A LAL G+ V LGL + H Sbjct: 1388 PERSLARNPLFQVVLALQSM--PAADLALPGLDVAAEPVRVGFAKFDLGLAVIEEHTADG 1445 Query: 414 LTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERD 472 + D +EY +L V+ + ++L+D +PER + S+D+L A ER Sbjct: 1446 TRAGIRGD-----WEYSTELFERGTVEALGSRLVRLLDAVADDPERTIGSVDLLDATERH 1500 Query: 473 SVLA---QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLA 529 +L + G L E T + V + LTY+EL RANRLA Sbjct: 1501 RLLVGLNTTDGPLPEERTLTAL----FEQQAAATPDATALVMGDRSLTYAELDARANRLA 1556 Query: 530 RWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQ 589 R + G GPE I+ L++ S++ + A+LAV K+GAAYLP+DP YP ERI ++ DARP Sbjct: 1557 RHLVALGAGPEQIVALQLPRSLDLVTAVLAVWKSGAAYLPVDPDYPPERIAHMRADARPA 1616 Query: 590 TVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAI 649 V+ D A AD+ L+D+DR PL P H AYVIYTSGSTG PKGV V+H ++ Sbjct: 1617 LVVDAIPDDTTLAAYADSR---LTDADRSAPLLPAHPAYVIYTSGSTGAPKGVVVAHRSL 1673 Query: 650 AEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVAD 709 A V A + + R L F+S+SFDA++ ++ L GA L++ D +A Sbjct: 1674 AATVPAQAAAFGLGTHSRVLNFASISFDAAVWELTSALLTGAGLVLADADDLLPGPSLAR 1733 Query: 710 LISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRN 769 L+ R +T+ + V G+A + A RFA + N Sbjct: 1734 LVHDRHITLIALPPSALPALPDGALPPG----TDLIVAGDATAPDQAARFAP--GRRMVN 1787 Query: 770 HYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQ 829 YG TE VC+T GA PIG P + YVLDE+L PVP V GE+Y+ G+ Sbjct: 1788 AYGLTETTVCATMSEPATGDGA--PPIGRPVAHARVYVLDERLRPVPPGVTGEMYVSGAG 1845 Query: 830 LARGYLGRPTLTAQRFIADPF-----NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIR 884 +ARGYL RP LTAQRF+ DP+ G R+YRTGDL R + G L F GRAD+QVKIR Sbjct: 1846 VARGYLHRPALTAQRFVPDPYALLFGETGTRMYRTGDLARLDADGRLHFAGRADQQVKIR 1905 Query: 885 GFRIELGEVESVITTHPAVRHCLVVA-EETEAGPMLAAYL 923 GFRIE GE+E+V+T HPAV V+A E+T L AYL Sbjct: 1906 GFRIEPGEIETVLTAHPAVAAGAVIAREDTPGDKQLVAYL 1945 Score = 344 bits (882), Expect = 7e-92 Identities = 224/570 (39%), Positives = 297/570 (52%), Gaps = 38/570 (6%) Query: 925 PAAAQVD---LEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRR 981 PA A+ D + E+R A +P +M P A+ ++ +P++ +GKLDR ALPAP Sbjct: 2334 PARAEQDAALVGELRDLVAQRLPAHMAPAAYVLLDRLPLSANGKLDRDALPAPDRGEDAA 2393 Query: 982 YREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRT 1041 + P T E + ++FA++ G VG + SFF LGGHSLLA RL+++IR+ G +L VR Sbjct: 2394 GQAPRTRREEILSTLFAEVLGLPAVGIDRSFFDLGGHSLLATRLLSRIRSVLGAELAVRD 2453 Query: 1042 IFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQ 1101 +F APT A LA R+ + ARP RP +PLS +Q Sbjct: 2454 LFQAPTVAALAERVD---------------------GAQEARPPLTARTRPAEVPLSFAQ 2492 Query: 1102 LAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQ 1161 WF +R+EG +N+P++LR G RHEALRT + E GVP Q Sbjct: 2493 YRLWFLHRMEGFGPTYNIPMSLRLTGTLDTAALRAALADVTARHEALRTVYPESGGVPRQ 2552 Query: 1162 -IVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVH 1220 ++H R Q D++ RR PL +A L L D HVLLL++H Sbjct: 2553 HVLHDVRPHFETADTTAQTLEADLTRAARRGFDLARELPL-RATLFRLAEDEHVLLLLMH 2611 Query: 1221 HIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT---- 1276 HI D S + DL AY ARL AP LP+Q+ADYA+WQR+ T Sbjct: 2612 HIAGDGWSWPPLARDLGDAYAARLAGRAPDLPPLPVQYADYALWQRDLLGDEDDPTSRHA 2671 Query: 1277 -ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEF 1335 +L YW AL LP+E+ + DR RP V RG+ V F+V L LA A+ F Sbjct: 2672 RQLAYWAGALDDLPEELQLPCDRPRPAVATHRGDTVPFAVDPDLHQRLNALATEGRASLF 2731 Query: 1336 MLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSI 1395 M+ QAA A +L + G GTDI LGSP+A R + A LVG F N +VLRTD SGDPT R + Sbjct: 2732 MVLQAAFAALLTRHGAGTDIPLGSPIAGRTDDALEDLVGFFVNTLVLRTDTSGDPTFREL 2791 Query: 1396 LVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWA-LVPRDLTGR 1454 L R++ L A AHQ++P E+LVE L P R+LSR+PLFQ ML F+ A L L R Sbjct: 2792 LQRVRESDLAAYAHQDVPFEKLVEKLRPERSLSRHPLFQVMLAFQNSGEARLALPGLDAR 2851 Query: 1455 GETTVVPLPVNFEVALLFLAIGMSVTPSGE 1484 LPV VA L + M +G+ Sbjct: 2852 A------LPVGVGVAKFDLHLSMVELRTGD 2875 Score = 38.9 bits (89), Expect = 6.4 Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 1/70 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQA-GALGLPFPPAMVFEHMTIA 1618 E L + E+L + D+N+F LGG S++A + + LG +FE T+A Sbjct: 4510 EEILCGLFAEVLGAPRVGTDDNFFELGGHSMLATRLVGRVKTVLGADIGVRTLFEAPTVA 4569 Query: 1619 ELAAAVDAAN 1628 LAA +D A+ Sbjct: 4570 ALAARIDGAD 4579 >tr|C6WBS4|C6WBS4_ACTMD Tax_Id=446462 SubName: Full=Cyclic nucleotide-binding protein;[Actinosynnema mirum] Length = 8211 Score = 798 bits (2061), Expect = 0.0 Identities = 546/1443 (37%), Positives = 732/1443 (50%), Gaps = 94/1443 (6%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS QRR+WFL+ +D ++ +A RL G +D + L +A++DV ARH LRT + D Sbjct: 4378 LSPAQRRLWFLEQVDEASGAYHLPLALRLTGPLDREALRSALDDVAARHESLRTVFP-DR 4436 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 +G P Q D V V W D T + L R F L E P+R + T Sbjct: 4437 DGVPAQAVLDGVRVPWAVVDATGA-------DLPPLLRACAVREFVLAVEQPVRAALFVT 4489 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA-AQFLSVEVLQNSA 217 DE VLL+V+HHI D S +L+ AY + P P Q+ + Q Sbjct: 4490 GPDEHVLLVVLHHIAADGWSMGPLSRDLATAYAARCRGEAPAWAPLPVQYADYALWQRDL 4549 Query: 218 APSVADVG--------YWAETLRXXXXXXXXXGVSGANPCR---RAQRRVRPLPAGLFSR 266 D G +W L P R R + L AGL +R Sbjct: 4550 LGDEGDEGGEFARQVAHWRTRLAGLPELITLP-TDRPRPARASHRGEHLAVELDAGLHAR 4608 Query: 267 VEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLL 325 + D AR A+ FMVL A L+ + D ++ P+ R+ A L G+F NTL+L Sbjct: 4609 LADLARASGATLFMVLQAGLAGLLTKLGAGEDVVIGSPIAGRTDEALDDLVGFFVNTLVL 4668 Query: 326 RITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMR 385 R T +FT V VRE L +A+Q V + +V NP R L V L Sbjct: 4669 RTDTSGDPSFTELVARVREGALEAYANQDVPFEHLVEVLNPARSLSHHPLLQVVLAVQ-N 4727 Query: 386 KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDDVSVEFEYQQQL-SSVLV 438 G AL G+ V + + + L L++++ P + EY L V Sbjct: 4728 APTGDFALPGLAVAGVPVPTGTSRLDLAISLTERRAEDGSPGGLVGAVEYSTDLFDRGTV 4787 Query: 439 DQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXX 498 + +L + +L+ A+P PL ++D+LG E ++ +++ P Sbjct: 4788 ELLLARWTRLLTAVTADPRLPLRAVDLLGGPEHRALADRNN---TTQPVAGEHFAALFRA 4844 Query: 499 XXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAML 558 V + LTY+EL RANR A + +G GPED++ LR+ S+E +VA+L Sbjct: 4845 VADRAPGATAVVGADETLTYAELDARANRFAHALVARGTGPEDVVALRLPRSVELVVAVL 4904 Query: 559 AVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPE---------LDVAERAAADNSD 609 VLKAGAAYLP+DPAYP RI+ ++ DAR V+ P+ L +AA D Sbjct: 4905 GVLKAGAAYLPVDPAYPAARIELMLADARCALVVDSPDVVNDPAGALLAGVAQAATDPVV 4964 Query: 610 LP------LSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMT 663 LP L D+D +RP + AYVIYTSGSTGRPKGV V+H + V V + Sbjct: 4965 LPDTDPVVLPDTDPRVLVRPENPAYVIYTSGSTGRPKGVVVTHGGVPSLVATQVERLALA 5024 Query: 664 AEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXX 723 + R LQ +S SFDA+ D+ TL GA L++ D L + G V Sbjct: 5025 PDSRVLQLASPSFDAAFWDLCATLLTGAALVLAPVDD--------PLSALTGADVTHATL 5076 Query: 724 XXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHM 783 + + V GEA P E+ R+A + N YGPTE VC+T Sbjct: 5077 PPSALASVDGEV----RATTLVVAGEACPPELVARWAP--GRRMVNAYGPTETTVCAT-- 5128 Query: 784 VVTG--SHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLT 841 +G + A IG+P N +VLD L VPD V+GELY+ G LARGYLGRP LT Sbjct: 5129 -ASGPLTPSADAPTIGLPIANARVHVLDAALRLVPDGVVGELYVSGPGLARGYLGRPGLT 5187 Query: 842 AQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 ++RF+ADPF PG R+YRTGDL R G LEFVGRADEQVK+RGFR+ELGEVES + H Sbjct: 5188 SERFVADPFGAPGSRMYRTGDLARWRRDG-LEFVGRADEQVKVRGFRVELGEVESALAAH 5246 Query: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 P+V L A VPA ++D+ E+ +PE++VP A + ++P+ Sbjct: 5247 PSVARVAATVRRDR----LVACAVPAGDRLDVAELDRFLRVLLPEHLVPSAIVTVTDLPL 5302 Query: 961 TVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSL 1020 + +GKLDR ALP P AT R P T E+ + +FA++ G VG D FF LGGHSL Sbjct: 5303 SPNGKLDRDALPDPVAKATGR--APRTPREQVLTGLFAEVLGLPEVGVADDFFDLGGHSL 5360 Query: 1021 LAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPK 1080 LA RL+A++R GV++ +R +F +PTPA LAA L +LD + LD Sbjct: 5361 LATRLIARVRTALGVEVPLRELFTSPTPAALAALLDGP-------ELDGRRFEGSGLDGS 5413 Query: 1081 -RARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 RARP RP+ +PLS +Q WF R+EG +N+P+ALR G Sbjct: 5414 GRARPALTARPRPEPVPLSFAQRRLWFLDRVEGPSATYNIPVALRLSGALDRDALRAALD 5473 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGP 1199 RHE+LRT F E +GVP Q V P V L V + +++ ++ R F +G Sbjct: 5474 DVVARHESLRTVFPEVDGVPVQRVLPEARVALDVTRVTGGLPGELA-RVARAPFDLAAGL 5532 Query: 1200 LLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFA 1259 L+A LLVLGPD HVLLL+VHHI D S + DL AY AR + AP W LP Q+A Sbjct: 5533 PLRAALLVLGPDEHVLLLVVHHIAGDGWSTGPLSRDLATAYAARRRGEAPAWAPLPAQYA 5592 Query: 1260 DYAVWQRNTFESNWG-----QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFS 1314 DYA+WQR S +L +W DALAGLP+ I++ TDR P V RG V Sbjct: 5593 DYALWQRELLGSTDDPRSAFSRQLAHWADALAGLPERIALPTDRPHPAVASHRGAQVPLD 5652 Query: 1315 VPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVG 1374 + A A L +L R GA+ FML A+LAV+ LG G DIA+GSP+A R + A LVG Sbjct: 5653 LDAGLHARLVELGRRTGASLFMLAHASLAVLFSGLGAGEDIAIGSPIAGRTDEALDDLVG 5712 Query: 1375 LFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQ 1434 F N +VLRTD SGDPT ++ R+ L A A+Q++P E LVEALNP R+LS +PLFQ Sbjct: 5713 FFVNTLVLRTDTSGDPTFTELVARVRERALSAYANQDVPFEHLVEALNPTRSLSHHPLFQ 5772 Query: 1435 NML 1437 ML Sbjct: 5773 VML 5775 Score = 777 bits (2007), Expect = 0.0 Identities = 544/1478 (36%), Positives = 728/1478 (49%), Gaps = 79/1478 (5%) Query: 39 GERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTT 98 GER LS QRR+WFL ++ NI +A+RL G +D L A+ DV+ARH LRT Sbjct: 2272 GERVPLSFSQRRLWFLHQLEGASANYNIPLAWRLTGALDLPALEAALADVLARHESLRTL 2331 Query: 99 YGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRI 158 + DT G +Q+ D R + P A E + + A R FDL ELPLR Sbjct: 2332 FP-DTGGATHQLVLDAPP----RPRVPVSPVA--ECDLAATATAAATRGFDLETELPLRA 2384 Query: 159 TVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQF 207 V DE VLLLVVHHI D S +L+ AY LP+ Sbjct: 2385 QVFALAPDEHVLLLVVHHIAGDGWSLGPLARDLATAYTARLRGHAPDFAPLPVQYADYAL 2444 Query: 208 LSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPC--RRAQRRVRPLPAG 262 +L + P S +W L P R LP Sbjct: 2445 WQHRLLGDHTDPTSSSARQAAHWTSALAGLPEVLQLPTDRPRPPIASHRGGFVEIDLPGE 2504 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 L + D A + AS FMVL A L+ R D V + R+ A L GYF N Sbjct: 2505 LHRALRDLAGRDGASLFMVLQAGLAALLTRLGAGHDVPVGTLIAGRTDQALDHLVGYFVN 2564 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLG 381 TL+LR T +FT + VRE LA +AHQ V + +V NP R V L Sbjct: 2565 TLVLRADTSGDPSFTELLGRVRERALAAYAHQDVPFEHLVEVLNPPRSLAHHPLFQVMLV 2624 Query: 382 FNMRKSAGGLALDGVVVRQLGLGAVAAHLPL--SLTIALDPDDVSVEF----EYQQQL-S 434 A A DG+ L + + L L S+T D D EY L Sbjct: 2625 LQNAPRAD-FAPDGLTASPLSITTTTSKLDLIFSVTERHDADGAPAGLGGFVEYSSDLYD 2683 Query: 435 SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 V++++ + +L+ A+P RP+ +D+L A ER + + E V P + + Sbjct: 2684 RSTVEELVARWARLLAAVTADPARPIGRVDLLTATERCELPRRP--EPVAAPRAALHELF 2741 Query: 495 XXXXXXXXXXXXXXXVSDEA---ELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSI 551 E ELTY EL RANRLA +G GPE ++ L + S+ Sbjct: 2742 AARAALVPDAVAVTSDGAEPTCRELTYRELEERANRLAHLLAARGAGPERLVALVLPRSL 2801 Query: 552 EFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLP 611 + +VA+LAVLK GAAYLPIDP YP R+ + DA P ++G LD+A A+ Sbjct: 2802 DLVVAVLAVLKTGAAYLPIDPDYPAARVAATLADAAPVLLVGEGGLDLAAERTAELLAAA 2861 Query: 612 LSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQF 671 + + R + P AYVIYTSGSTG PKGV V H + + + D W F Sbjct: 2862 PTTAPPAR-VDPACAAYVIYTSGSTGTPKGVVVPHANVVRLFEATDHLFAFGERDVWTLF 2920 Query: 672 SSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXX 731 S +FD S+ +++ L G +L+V +L+ R VTV Sbjct: 2921 HSYAFDFSVWELWGALLHGGRLVVVPHGTSRSPERFLELLERERVTVLNQTPSAFHQLDR 2980 Query: 732 XXXXXQWR--QLRHVPVGGEAL-PGEVADRFAGYFD--AELRNHYGPTEAVVCSTHMVVT 786 LR+V GGEAL P +A ++ + D L N YG TE V TH+ + Sbjct: 2981 AERERPTALDALRYVVFGGEALEPTRLAGWYSRHADDAPALVNMYGITETTVHVTHLPLD 3040 Query: 787 GSHGARV-VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 + A IG P ++ AYVLD L PVP V+GELY+ G+ LARGYL RP LTA RF Sbjct: 3041 RARAADPGSAIGAPVPDLGAYVLDHALSPVPRGVVGELYVPGAGLARGYLNRPGLTASRF 3100 Query: 846 IADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVR 904 +ADPF PG R+YRTGDL R G LE+ GRAD+QVK+RGFRIELGE+E+ + HP V Sbjct: 3101 VADPFGEPGQRMYRTGDLARWRADGGLEYAGRADDQVKVRGFRIELGEIEAALGAHPDVA 3160 Query: 905 HCLVVAEETEAGPM-LAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTV 962 V A A L AY VPAA ++ D E +RAH A +P +MVP F + IP+T Sbjct: 3161 QAAVTARREGADDTRLVAYTVPAAGSEHDPERLRAHLADRLPRHMVPSVFVALDAIPLTG 3220 Query: 963 SGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLA 1022 +GKLDR+ALPAP+P TRR R T ER +C +F ++ G VGA+D FF LGGHSLLA Sbjct: 3221 NGKLDRKALPAPSPAPTRRSRPARTPRERVLCELFTEVLGVAEVGADDDFFALGGHSLLA 3280 Query: 1023 ARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRA 1082 RLV+++R+ GV+L +R +F +PT AGLAA L D RA Sbjct: 3281 TRLVSRVRSALGVELDLRALFGSPTVAGLAAVLD---------------------DADRA 3319 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 RP + RP +PLS +Q WF +++EG +N+PLA R G Sbjct: 3320 RPAVTSAPRPNVVPLSSAQRRLWFLHQLEGPSATYNIPLAWRLTGELDRAALEAALGDLV 3379 Query: 1143 XRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQ 1202 RHE LRT + H VP+Q+V L VRA+D D + T F + P L+ Sbjct: 3380 TRHEVLRTVYPAHGDVPHQVVLDPFRPDLPVRAVDAD-LPALLTASAARGFDLVARPPLR 3438 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYA 1262 A L L P HVLLL+VHHI D SL + DL AY ARL+ P W LP+Q+ADYA Sbjct: 3439 AELFALAPTEHVLLLVVHHIAGDGWSLGPLARDLATAYTARLRGGEPDWAPLPVQYADYA 3498 Query: 1263 VWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPA 1317 +WQ + E + + +W ALAGLP+ +++ TDR RP RG + + Sbjct: 3499 LWQEDLLGDPADERSAAARQTAHWTRALAGLPERLALPTDRPRPATASYRGGRLPVELGP 3558 Query: 1318 ARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFA 1377 L +L +GA+ FM+ Q LA +L ++G G D+ +G+ +A R + A LVG F Sbjct: 3559 ELHRGLVELGREHGASLFMVLQTGLAALLSRMGAGHDVPVGTLIAGRTDEALDDLVGFFV 3618 Query: 1378 NVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNML 1437 N +VLRTD SGDP+ ++L R++ L A A+Q+LP +R+VEA+NP R+LS PLFQ ML Sbjct: 3619 NTLVLRTDTSGDPSFTALLGRVRESALTAYANQDLPFDRVVEAVNPARSLSHQPLFQVML 3678 Query: 1438 NFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAI 1475 + VPR +PV+ A+ L++ Sbjct: 3679 ALQN-----VPRSGLALPGLATEVVPVHPATAMFDLSV 3711 Score = 765 bits (1975), Expect = 0.0 Identities = 535/1445 (37%), Positives = 718/1445 (49%), Gaps = 91/1445 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS QRR+WFL ++ T NI +A RL G++D D L A+ DVVARH LRT + Sbjct: 1223 ERVPLSPAQRRLWFLHQVEGAGATYNIPLALRLTGVLDRDALRAALGDVVARHESLRTVF 1282 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLP-EAGHERQIESLAADEFGRPFDLTNELPLRI 158 + +GEP Q + LP A + L A FDL +++PL Sbjct: 1283 PL-VDGEPVQHVLPPAPLP--------LPVTATTADALPDLLAASARHGFDLASDVPLHA 1333 Query: 159 TVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQF 207 + T +E LLLV HHI D S +++ AY LP+ Sbjct: 1334 ELFTTGPEEHALLLVAHHIASDGWSMGALSRDVATAYAARLRGAAPDWAPLPVQYADHAL 1393 Query: 208 LSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP--LPAG 262 E + A P + + +W L V P LPA Sbjct: 1394 WQAEAAGDEADPDSRAARGLAFWRRALAGLPEVLDLPADRPRPTTTSHLGGVVPVVLPAD 1453 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 L + A AS F+VL AA L+ + D + PV RS AA L G+F N Sbjct: 1454 LHRGLRAVALDRGASLFLVLQAALAALLDKLGAGRDIPIGTPVAGRSDTAADDLVGFFVN 1513 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG--MDLLVR 379 TL+LR T TFT ++ VRET LA + HQ V +R+V NP R L+ Sbjct: 1514 TLVLRADTSGDPTFTELLDRVRETALAAYEHQDVPFERLVEALNPTRSLAHNPLYQTLLA 1573 Query: 380 LGFNMRKSAGGLALDGVV-VRQLGLGAVAAHLPLSLTIALD--PDDVSVEFEYQQQLSSV 436 L + L GV + G L L+ T D P V+ EY L Sbjct: 1574 LQHDPLGPFDPPGLTGVAELVHTGTAKCDLSLILTETTTADGAPSGVTGSAEYSADLFDP 1633 Query: 437 LVDQMLVH-YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 ++LV +L L+ + +A+P R LS+ D+ A ER + +H + + Sbjct: 1634 DTAELLVRRWLDLLRQVVADPGRRLSAFDVRTAAERATTPPVTHRPRGALHTLFEARADR 1693 Query: 496 XXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIV 555 D LTY+EL RANRLAR I +G GPE ++ L + S++ +V Sbjct: 1694 APDAVAV-------TCDGESLTYAELDARANRLARLLIERGAGPERLVALSLPRSLDLVV 1746 Query: 556 AMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDS 615 A+LAVLK+GAAYLP+DP YP R+ +L+ DARP ++ A+ A D + + Sbjct: 1747 AVLAVLKSGAAYLPVDPGYPAARVAFLLDDARPALLVTAGAS--AQEHALDLDAVDWAAL 1804 Query: 616 DRLRP---LRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFS 672 D RP + P AYVIYTSGSTG PKGV V H + + D W F Sbjct: 1805 DPTRPAVAVHPECAAYVIYTSGSTGNPKGVVVPHANVVRLFDATDHWFGFDEHDVWTLFH 1864 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 S +FD S+ +++ L G +L+V + +L+ R VTV Sbjct: 1865 SYAFDFSVWELWGPLLHGGRLVVVPHETSRSPERFLELLERERVTVLNQTPSAFHQLDRA 1924 Query: 733 XXXXQWR--QLRHVPVGGEALPGEVADRFAGYFDAE------LRNHYGPTEAVVCSTHMV 784 LRHV GGEAL R AG++ L N YG TE V TH Sbjct: 1925 ERERPTALDALRHVVFGGEALD---LPRLAGWYSRHADDAPALVNMYGITETTVHVTHTA 1981 Query: 785 VTGSHGARVVP--IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTA 842 + S P IG ++ A+VLD +L PVP V GEL++ G+ LARGYL RP LTA Sbjct: 1982 LDRSRAVPGAPSDIGAAIPDLRAHVLDARLKPVPTGVTGELHISGAGLARGYLNRPGLTA 2041 Query: 843 QRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHP 901 RF+ADPF PG R+YRTGDL RRN G LEF+GRAD QVK+RGFRIELGE+E+ + HP Sbjct: 2042 SRFVADPFGEPGQRMYRTGDLARRNRHGALEFLGRADHQVKVRGFRIELGEIEAALAEHP 2101 Query: 902 AVRHCLVVAEETEAGPM-LAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIP 959 V VVA + A L AY V A A + +RAH A +P +MVP AF + IP Sbjct: 2102 EVAQAAVVARQDRADDTRLVAYTVAVAGAHPRPDALRAHLAQRLPAHMVPAAFVPLDAIP 2161 Query: 960 MTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHS 1019 +T +GKLDR+ALP P A R T E+ +C +F ++ G VG +D FF LGGHS Sbjct: 2162 LTGNGKLDRKALPEPEA-ALVGGRAARTPQEQLLCELFGEVLGVAGVGVDDGFFDLGGHS 2220 Query: 1020 LLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDP 1079 LLA RLV+++RA GV+L +RT+F++PTPAGLAA L Sbjct: 2221 LLATRLVSRVRATLGVELELRTLFESPTPAGLAAVLG---------------------GA 2259 Query: 1080 KRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 RAR R +R+PLS SQ WF +++EGA +N+PLA R G Sbjct: 2260 GRARLALTPQERGERVPLSFSQRRLWFLHQLEGASANYNIPLAWRLTGALDLPALEAALA 2319 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIV--HPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPES 1197 RHE+LRT F + G +Q+V P R ++ V + + + +T F E+ Sbjct: 2320 DVLARHESLRTLFPDTGGATHQLVLDAPPRP-RVPVSPVAECDLAATATAAATRGFDLET 2378 Query: 1198 GPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQ 1257 L+A + L PD HVLLL+VHHI D SL + DL AY ARL+ +AP + LP+Q Sbjct: 2379 ELPLRAQVFALAPDEHVLLLVVHHIAGDGWSLGPLARDLATAYTARLRGHAPDFAPLPVQ 2438 Query: 1258 FADYAVWQRNTFESNWGQT-----ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQ 1312 +ADYA+WQ + T + +W ALAGLP+ + + TDR RP + RG V+ Sbjct: 2439 YADYALWQHRLLGDHTDPTSSSARQAAHWTSALAGLPEVLQLPTDRPRPPIASHRGGFVE 2498 Query: 1313 FSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQL 1372 +P AL LA R+GA+ FM+ QA LA +L +LG G D+ +G+ +A R + A L Sbjct: 2499 IDLPGELHRALRDLAGRDGASLFMVLQAGLAALLTRLGAGHDVPVGTLIAGRTDQALDHL 2558 Query: 1373 VGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPL 1432 VG F N +VLR D SGDP+ +L R+ L A AHQ++P E LVE LNPPR+L+ +PL Sbjct: 2559 VGYFVNTLVLRADTSGDPSFTELLGRVRERALAAYAHQDVPFEHLVEVLNPPRSLAHHPL 2618 Query: 1433 FQNML 1437 FQ ML Sbjct: 2619 FQVML 2623 Score = 753 bits (1943), Expect = 0.0 Identities = 536/1498 (35%), Positives = 733/1498 (48%), Gaps = 94/1498 (6%) Query: 21 AESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDR 80 A+ A S+ +P + P LS QRR+WFL ++ T NI +A+RL G +D Sbjct: 3316 ADRARPAVTSAPRPNVVP-----LSSAQRRLWFLHQLEGPSATYNIPLAWRLTGELDRAA 3370 Query: 81 LHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLA 140 L A+ D+V RH +LRT Y + P+QV D R DL P + + +L Sbjct: 3371 LEAALGDLVTRHEVLRTVYPAHGD-VPHQVVLDPF-----RPDL---PVRAVDADLPALL 3421 Query: 141 ADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN---- 196 R FDL PLR + E VLLLVVHHI D S +L+ AY Sbjct: 3422 TASAARGFDLVARPPLRAELFALAPTEHVLLLVVHHIAGDGWSLGPLARDLATAYTARLR 3481 Query: 197 -------DLPINDPAAQFLSVEVLQNSA---APSVADVGYWAETLRXXXXXXXXXGVSGA 246 LP+ ++L + A + + +W L Sbjct: 3482 GGEPDWAPLPVQYADYALWQEDLLGDPADERSAAARQTAHWTRALAGLPERLALP-TDRP 3540 Query: 247 NPCRRAQRRVR-PLPAG--LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSV 303 P + R R P+ G L + + R+ AS FMVL L+ R D V Sbjct: 3541 RPATASYRGGRLPVELGPELHRGLVELGREHGASLFMVLQTGLAALLSRMGAGHDVPVGT 3600 Query: 304 PVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVR 362 + R+ A L G+F NTL+LR T +FT+ + VRE+ L +A+Q + DRVV Sbjct: 3601 LIAGRTDEALDDLVGFFVNTLVLRTDTSGDPSFTALLGRVRESALTAYANQDLPFDRVVE 3660 Query: 363 EANPERMGRDGMDLLVRLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPD 421 NP R V L N+ +S GLAL G+ + + A LS+T+ Sbjct: 3661 AVNPARSLSHQPLFQVMLALQNVPRS--GLALPGLATEVVPVHPATAMFDLSVTLLERDG 3718 Query: 422 DVSVE--FEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQS 478 D + EY L V + + +L++ ALA+P RPL +D+L ER +L + Sbjct: 3719 DGGLHGWVEYAADLFDEATVRSLTTRWTRLLETALADPARPLGRIDVLTDAERRLLLVER 3778 Query: 479 HGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFG 538 + P T++ V E ELTY+EL R++ LA +G+G G Sbjct: 3779 NRTAHHDPVTSL--PALFAEQVRRTPDTTAVVFGEVELTYAELDARSDALAHVLVGRGAG 3836 Query: 539 PEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELD 598 PE ++ LR+ +E +VA+LAVLK+GAAYLP+DP YP R+++++ DARP V+ P Sbjct: 3837 PERVVALRLPRGVEQLVALLAVLKSGAAYLPVDPDYPAARVEFMLADARPVLVLDDPADV 3896 Query: 599 VAERAAADNSDL--PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 A A D D PL P H AYVIYTSGSTG PK V + A+ ++ Sbjct: 3897 RAHWHATDRHDTAAPLGTGHD-----PRHPAYVIYTSGSTGTPKAVVMPSGALVNLLRWH 3951 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGV 716 R QF+S SFD S +I L G L+ P + + D + R V Sbjct: 3952 HRALGGEVGARVAQFTSTSFDVSAQEILSALLFGKTLVAPDEEQRRSAELLVDWLDRHRV 4011 Query: 717 T--VXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEA--LPGEVADRFAGYFDAELRNHYG 772 LR + GEA L G + L NHYG Sbjct: 4012 EELYAPDLVLEAVAEAANERGRDLPALRLLAQAGEAMRLGGALRQFQRRVPGRSLHNHYG 4071 Query: 773 PTEA-VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLA 831 P E VV + + S VPIG P N YVLD L PVP V GELYL G+ LA Sbjct: 4072 PAETHVVTAFPLPADLSACPLPVPIGRPVANTAVYVLDAALRPVPPGVPGELYLAGAGLA 4131 Query: 832 RGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIEL 890 RGYL RP LT+ RF+ADPF PG R+YRTGD+ R GELEF GRAD+QVK+RGFR+E Sbjct: 4132 RGYLNRPGLTSARFVADPFGGPGSRMYRTGDVARWRADGELEFGGRADDQVKVRGFRVEP 4191 Query: 891 GEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVPAAAQVDLEE-IRAHTAAAVPEYMV 948 GEVE+V+ HP V +V+A + G L Y VPA + +RAH A +P+++V Sbjct: 4192 GEVEAVLAGHPEVARAVVLARSDAPGGARLVGYAVPAPGRAPTARALRAHLADLLPDHLV 4251 Query: 949 PGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGA 1008 P + ++ IP+T +GKLDR ALPAP R P T E + +FA++ G VG Sbjct: 4252 PSSVVLLDAIPLTPNGKLDRAALPAPGTDEPEAARRPRTPREEILRELFAEVLGLPEVGV 4311 Query: 1009 EDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLD 1068 ++ FF LGGHSLLA RL++++RA G + +R +F+APT AGLA RL Sbjct: 4312 DEDFFALGGHSLLATRLLSRVRATLGAEPGLRALFEAPTAAGLATRL------------- 4358 Query: 1069 NLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGP 1128 + P ARP RP +PLS +Q WF +++ A +++PLALR GP Sbjct: 4359 ---SGGGVRAPLTARP------RPALVPLSPAQRRLWFLEQVDEASGAYHLPLALRLTGP 4409 Query: 1129 XXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL 1188 RHE+LRT F + +GVP Q V V AV + + Sbjct: 4410 LDREALRSALDDVAARHESLRTVFPDRDGVPAQAVLDGVRVPWAVVDATGADLPPLLRAC 4469 Query: 1189 RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNA 1248 F ++A L V GPD HVLL+++HHI +D S+ + DL AY AR + A Sbjct: 4470 AVREFVLAVEQPVRAALFVTGPDEHVLLVVLHHIAADGWSMGPLSRDLATAYAARCRGEA 4529 Query: 1249 PQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRV 1303 P W LP+Q+ADYA+WQR+ E ++ +WR LAGLP+ I++ TDR RP Sbjct: 4530 PAWAPLPVQYADYALWQRDLLGDEGDEGGEFARQVAHWRTRLAGLPELITLPTDRPRPAR 4589 Query: 1304 LGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAA 1363 RGE + + A A L LA +GAT FM+ QA LA +L KLG G D+ +GSP+A Sbjct: 4590 ASHRGEHLAVELDAGLHARLADLARASGATLFMVLQAGLAGLLTKLGAGEDVVIGSPIAG 4649 Query: 1364 RVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNP 1423 R + A LVG F N +VLRTD SGDP+ ++ R+ L+A A+Q++P E LVE LNP Sbjct: 4650 RTDEALDDLVGFFVNTLVLRTDTSGDPSFTELVARVREGALEAYANQDVPFEHLVEVLNP 4709 Query: 1424 PRALSRNPLFQNML---NFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMS 1478 R+LS +PL Q +L N D+AL + G VP+P + L LAI ++ Sbjct: 4710 ARSLSHHPLLQVVLAVQNAPTGDFALPGLAVAG------VPVPTG--TSRLDLAISLT 4759 Score = 543 bits (1398), Expect = e-151 Identities = 403/1071 (37%), Positives = 530/1071 (49%), Gaps = 67/1071 (6%) Query: 24 GLAAE---QSSDQPGICP---GERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVD 77 GLAA + +P + P ER LS QRR+WFL +D T + +A RL G +D Sbjct: 6868 GLAARLDAAGAARPALVPVERPERVPLSFAQRRLWFLHQVDGPSATYTMPLALRLTGTLD 6927 Query: 78 EDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIE 137 + L A+ DV+ARH LRT + D G P+Q D P H Sbjct: 6928 REALRNALGDVLARHESLRTVFR-DEGGVPHQHVLDPAPP----------PLLVHPAGAG 6976 Query: 138 SLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN- 196 SL D R FDL + P+RI + T E VLL+VVHHI D S +L+ AY Sbjct: 6977 SLL-DSARRGFDLAEQPPIRIELFETGPAEHVLLIVVHHIAADGWSMGPLSRDLATAYAA 7035 Query: 197 ----------DLPINDPAAQFLSVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXGV 243 LP+ ++L AP + YW L Sbjct: 7036 RCRGEAPAWAPLPVQYADYALWQRDLLGEPTAPDSRFAEQLAYWTGALAGLPECVELPTD 7095 Query: 244 SGANPCRRAQRRVRP--LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLV 301 + V P LPA L V D A AS FMVL A L+ + D ++ Sbjct: 7096 RPRPAVASHRGDVLPVELPARLHRAVRDLAAAQGASVFMVLQAGLAALLTKLGAGEDVVI 7155 Query: 302 SVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV 360 P+ R+ A L G+F NTL+LR T +FT + VRE LA +A+Q V + + Sbjct: 7156 GSPIAGRTDEALDELVGFFVNTLVLRTDTSGNPSFTRLLGRVRENALAAYANQDVPFEYL 7215 Query: 361 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVV--RQLGLGAVAAHLPLSLTIAL 418 V NP R V LG S G AL G+ + G A L +SL L Sbjct: 7216 VEAVNPARSLAHHPLFQVVLGLQNAPS-GDFALPGLEIGHESAPTGTARADLTISLAERL 7274 Query: 419 DPDDV------SVEFE---YQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAG 469 PD +VE+ + + + LVD+ + +L+D A+P+ P D+LG Sbjct: 7275 RPDGEPDGLVGAVEYATDLFDRDTVAALVDR----FARLLDAVTADPDVPFQRADLLGPA 7330 Query: 470 ERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLA 529 ERD +L + G VE PA + V +AELTY+EL RA+RLA Sbjct: 7331 ERDRLL-ELGGAPVEPPAGDLA--GLFAEQARRTPDAVAVVHGDAELTYAELDARADRLA 7387 Query: 530 RWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQ 589 G+G E + + + S E +VA+LAVLKAG AY+P+DP YP R+ ++ + Sbjct: 7388 AALAGRGVERETRVAVLLERSPELVVALLAVLKAGGAYVPLDPRYPAARVQLILRGSGAT 7447 Query: 590 TVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAI 649 TV+ L E AA + + L + + P LAYV+YTSGSTG PKGV V+H + Sbjct: 7448 TVLTPEVLAELESAAPETAALGVPEGVG----HPEQLAYVMYTSGSTGTPKGVGVTHRDV 7503 Query: 650 AEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVAD 709 E V W A +R L + V+FD S +++V L G ++V P F D + + + Sbjct: 7504 VELALDPV--WRGGAHERVLLHAPVAFDLSTYELWVPLLSGGCVVVTPPGEF-DPAVLHE 7560 Query: 710 LISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEAL-PGEVADRFAGYFDAELR 768 +I+R+ VT + +R + GEA+ PG V + + Sbjct: 7561 VITRQRVTALVLPYSLLSLLVDERPGT-FAHVRELITAGEAVAPGAVTEVLRACPGVTVV 7619 Query: 769 NHYGPTEAVVCSTH-MVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGG 827 N YGPTE V STH V T + AR VPIG P R VLD L VP V+GEL++ G Sbjct: 7620 NAYGPTETTVYSTHHRVTTTPNPARPVPIGGPTRGTCLRVLDRGLRLVPPGVVGELHIAG 7679 Query: 828 SQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGF 886 S LARGY+G P TA+RF+ADPF PG R+YRTGDLVRR GELEFVGRAD QVK+RGF Sbjct: 7680 SGLARGYVGAPGRTAERFVADPFGAPGSRMYRTGDLVRRLPGGELEFVGRADGQVKLRGF 7739 Query: 887 RIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPA-AAQVDLEEIRAHTAAAVP 944 RIELGEVE+ + P V VV E G P L AYLVPA A VD + VP Sbjct: 7740 RIELGEVETALERLPEVARATVVVREDRPGHPCLVAYLVPAPGAVVDPGALVEPLRGQVP 7799 Query: 945 EYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQ 1004 EY P AF V+ +P+T +GKLDR ALPAP P T E+ +C +FA + GR+ Sbjct: 7800 EYAAPSAFVVLDALPLTPNGKLDRAALPAPELPVRGEGLMPRTPHEQLLCELFAGVLGRE 7859 Query: 1005 RVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 RV ++ FF LGGHSLLAARLVA +R GV L +RT+F++PTPA LAA L Sbjct: 7860 RVHVDEGFFELGGHSLLAARLVAMVRDVLGVPLGLRTLFESPTPAALAAHL 7910 Score = 532 bits (1370), Expect = e-148 Identities = 354/905 (39%), Positives = 455/905 (50%), Gaps = 94/905 (10%) Query: 620 PLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAED--RWLQFSSVSFD 677 P P H AY ++TSGSTGRPKGV ++H A+A + A T+ R +S SFD Sbjct: 714 PADPRHAAYALHTSGSTGRPKGVVITHGALANLLVHHRATLFATSARPLRVAWSTSTSFD 773 Query: 678 ASLADIFVTLFLGAQLIVPKPDAFGD-ISYVADLISRRGVTVXXXXXXXXXXXXXXXXXX 736 A+ D LF G +L V + D + VA + ++R V Sbjct: 774 ATW-DQLACLFAGHELHVVDHTTWTDPAACVAHVAAQRLDFVESAPSYLRVLVAKGLLDD 832 Query: 737 QWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPI 796 R+ V GGEA+P E+ R NHYGPTE V +T + S AR V I Sbjct: 833 PERRPSVVVAGGEAVPEELWRRLRAVDGVRAVNHYGPTECAVDATTADLADS--ARPV-I 889 Query: 797 GVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMR 855 G P +V A VLD L P P V GELYL G+ + RGYLG+ LTA+RF+ADPF PG R Sbjct: 890 GRPIGHVRALVLDSALQPSPPGVPGELYLAGAGVGRGYLGQSALTAERFVADPFGVPGQR 949 Query: 856 LYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEE--- 912 +YRTGDLVRR G++E +GRAD+QVK+RGFR+E GE+E+ + HP V VV Sbjct: 950 MYRTGDLVRRTGTGDVEHLGRADDQVKVRGFRVEPGEIEARLLEHPGVARAAVVVRHRGG 1009 Query: 913 --------------------------------------------TEAGPMLAAYLVPAA- 927 T A P AA PA Sbjct: 1010 ANHLAAYLVHADTAQGTAAPDTPASNTPAMPNTAATPNTAATPNTAATPGTAALSAPAPG 1069 Query: 928 ----------AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPI 977 A D +RAH +PE+M+P F V+ +P+T SGKLDRRALP Sbjct: 1070 LTAAGTAASDAVPDPAALRAHLRERLPEHMIPSVFVVLDALPLTTSGKLDRRALP-DVGA 1128 Query: 978 ATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDL 1037 R P ER +C +F ++ G V A+ FF LGGHSLLA RLVA +RA GV+L Sbjct: 1129 EVSEGRPPRNERERVLCGLFGEVLGVAAVAADADFFALGGHSLLAVRLVAAVRASLGVEL 1188 Query: 1038 TVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPL 1097 + +FDAPTP LA R+ D A PL P+ RP+R+PL Sbjct: 1189 GLADLFDAPTPEALALRV------------DAAAPARAPLRPR---------PRPERVPL 1227 Query: 1098 SHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEG 1157 S +Q WF +++EGA +N+PLALR G RHE+LRT F +G Sbjct: 1228 SPAQRRLWFLHQVEGAGATYNIPLALRLTGVLDRDALRAALGDVVARHESLRTVFPLVDG 1287 Query: 1158 VPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLL 1217 P Q V P + L V A D D+ RH F S L A L GP+ H LLL Sbjct: 1288 EPVQHVLPPAPLPLPVTATTADALPDLLAASARHGFDLASDVPLHAELFTTGPEEHALLL 1347 Query: 1218 IVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESN 1272 + HHI SD S+ + D+ AY ARL+ AP W LP+Q+AD+A+WQ + Sbjct: 1348 VAHHIASDGWSMGALSRDVATAYAARLRGAAPDWAPLPVQYADHALWQAEAAGDEADPDS 1407 Query: 1273 WGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGA 1332 L +WR ALAGLP+ + + DR RP G VV +PA L +A GA Sbjct: 1408 RAARGLAFWRRALAGLPEVLDLPADRPRPTTTSHLGGVVPVVLPADLHRGLRAVALDRGA 1467 Query: 1333 TEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTL 1392 + F++ QAALA +L KLG G DI +G+PVA R + A LVG F N +VLR D SGDPT Sbjct: 1468 SLFLVLQAALAALLDKLGAGRDIPIGTPVAGRSDTAADDLVGFFVNTLVLRADTSGDPTF 1527 Query: 1393 RSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWA-LVPRDL 1451 +L R+T L A HQ++P ERLVEALNP R+L+ NPL+Q +L + + P L Sbjct: 1528 TELLDRVRETALAAYEHQDVPFERLVEALNPTRSLAHNPLYQTLLALQHDPLGPFDPPGL 1587 Query: 1452 TGRGE 1456 TG E Sbjct: 1588 TGVAE 1592 Score = 412 bits (1058), Expect = e-112 Identities = 326/914 (35%), Positives = 442/914 (48%), Gaps = 78/914 (8%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS QRR+WFL ++ T NI VA RL+G +D D L A++DVVARH LRT + + Sbjct: 5431 LSFAQRRLWFLDRVEGPSATYNIPVALRLSGALDRDALRAALDDVVARHESLRTVFP-EV 5489 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 +G P Q + V D+TR+ G ++ +A PFDL LPLR ++ Sbjct: 5490 DGVPVQRVLPEARVAL---DVTRVT-GGLPGELARVAR----APFDLAAGLPLRAALLVL 5541 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA-AQFLSVEVLQNSA 217 DE VLLLVVHHI D S +L+ AY + P P AQ+ + Q Sbjct: 5542 GPDEHVLLLVVHHIAGDGWSTGPLSRDLATAYAARRRGEAPAWAPLPAQYADYALWQREL 5601 Query: 218 APSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAGLFSR 266 S D + +WA+ L +P + R + L AGL +R Sbjct: 5602 LGSTDDPRSAFSRQLAHWADALAGLPERIALP-TDRPHPAVASHRGAQVPLDLDAGLHAR 5660 Query: 267 VEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLL 325 + + R+ AS FM+ A+ VL D + P+ R+ A L G+F NTL+L Sbjct: 5661 LVELGRRTGASLFMLAHASLAVLFSGLGAGEDIAIGSPIAGRTDEALDDLVGFFVNTLVL 5720 Query: 326 RITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMR 385 R T TFT V VRE L+ +A+Q V + +V NP R V L Sbjct: 5721 RTDTSGDPTFTELVARVRERALSAYANQDVPFEHLVEALNPTRSLSHHPLFQVMLAVQ-N 5779 Query: 386 KSAGGLALDGVVVRQLGL--GAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVD---- 439 G L G+ V + G L SL D D + ++ L D Sbjct: 5780 IPMGDFDLPGLGVEPVPAPTGTAKFDLGFSLVERFDADGAPAGIVGYVEHATDLYDGATA 5839 Query: 440 -QMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXX 498 ++ +++L+D A + P+ +D+L A ER ++L VE T V Sbjct: 5840 TTLVRRWVRLLDAVSAASDLPIRRVDLLSADERRALLTGPAVVGVETRTLTGVFDEVVRA 5899 Query: 499 XXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAML 558 D LTY+ L A+R A + +G G ED++ L + S+E +VA+L Sbjct: 5900 HPDAVAVEL----DGTALTYAALDAWADRFAGDLVARGIGAEDLVALELPRSLELVVAVL 5955 Query: 559 AVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRL 618 VLKAGAAYLP+DPAYP R ++ DARP V+ R P+ D+ Sbjct: 5956 GVLKAGAAYLPVDPAYPAARKAAMVGDARPALVVDRTG--------------PVVDAGGA 6001 Query: 619 RPL---RPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 P+ G+ AYVI+TSGSTGRPKGV V+H ++ V V + + A DR LQF+S S Sbjct: 6002 APVGGPAAGNAAYVIHTSGSTGRPKGVVVTHASVVRLVDAQVERFAIGAGDRVLQFASPS 6061 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FDAS++++F L GA ++ D G +++ GVT Sbjct: 6062 FDASVSELFTALLTGATAVL-TADPVGALAHA-------GVTHATVPPSVLAAVPEI--- 6110 Query: 736 XQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVP 795 + V GEA E+ R+A + N YGPTE VC+T M + S G+ V Sbjct: 6111 ----SATTLVVAGEACSPELVARWAP--GRRMINAYGPTETTVCAT-MSLPLSPGSGVPT 6163 Query: 796 IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF-NPGM 854 IG + VLD L VP V+GELY+ GS +ARGYLGRP LT++RF+ADPF PG Sbjct: 6164 IGRAAPHAAVRVLDGGLRLVPPGVVGELYVAGSGVARGYLGRPGLTSERFVADPFGEPGS 6223 Query: 855 RLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE 914 R+YRTGDLVR G LEFVGRADEQVK+RGFR+E GEV++ I HP V C VVA + Sbjct: 6224 RMYRTGDLVRWRADG-LEFVGRADEQVKVRGFRVEPGEVQAAIAGHPDVAACAVVARRDQ 6282 Query: 915 A-GPMLAAYLVPAA 927 A L AYLVP A Sbjct: 6283 ADDTRLVAYLVPRA 6296 Score = 377 bits (969), Expect = e-102 Identities = 227/562 (40%), Positives = 309/562 (54%), Gaps = 42/562 (7%) Query: 934 EIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWI 993 ++RAH +PE++VP AF V+ +P+T GKLDR ALPAP A R R P T E + Sbjct: 6753 DVRAHLVERLPEHLVPSAFVVLDALPLTPVGKLDRAALPAPDAGA-RPGRSPRTPREELL 6811 Query: 994 CSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAA 1053 C +FA++ G RVG +D FF LGGHSLLA RLV+++RA V+L VR +F+ PTP GLAA Sbjct: 6812 CGLFAEVLGLDRVGVDDDFFDLGGHSLLATRLVSRVRAVLAVELDVRALFETPTPEGLAA 6871 Query: 1054 RLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGA 1113 RL D A ARP V RP+R+PLS +Q WF ++++G Sbjct: 6872 RL------------DAAGA---------ARPALVPVERPERVPLSFAQRRLWFLHQVDGP 6910 Query: 1114 REEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAV 1173 + MPLALR G RHE+LRT F + GVP+Q V L V Sbjct: 6911 SATYTMPLALRLTGTLDREALRNALGDVLARHESLRTVFRDEGGVPHQHVLDPAPPPLLV 6970 Query: 1174 RAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVF 1233 D + R F P ++ L GP HVLL++VHHI +D S+ + Sbjct: 6971 HPAGAGSLLDSA----RRGFDLAEQPPIRIELFETGPAEHVLLIVVHHIAADGWSMGPLS 7026 Query: 1234 DDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF------ESNWGQTELDYWRDALAG 1287 DL AY AR + AP W LP+Q+ADYA+WQR+ +S + + +L YW ALAG Sbjct: 7027 RDLATAYAARCRGEAPAWAPLPVQYADYALWQRDLLGEPTAPDSRFAE-QLAYWTGALAG 7085 Query: 1288 LPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLH 1347 LP+ + + TDR RP V RG+V+ +PA A+ LA GA+ FM+ QA LA +L Sbjct: 7086 LPECVELPTDRPRPAVASHRGDVLPVELPARLHRAVRDLAAAQGASVFMVLQAGLAALLT 7145 Query: 1348 KLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDAL 1407 KLG G D+ +GSP+A R + A +LVG F N +VLRTD SG+P+ +L R+ L A Sbjct: 7146 KLGAGEDVVIGSPIAGRTDEALDELVGFFVNTLVLRTDTSGNPSFTRLLGRVRENALAAY 7205 Query: 1408 AHQELPIERLVEALNPPRALSRNPLFQNML---NFRGEDWALVPRDLTGRGETTVVPLPV 1464 A+Q++P E LVEA+NP R+L+ +PLFQ +L N D+AL ++ P Sbjct: 7206 ANQDVPFEYLVEAVNPARSLAHHPLFQVVLGLQNAPSGDFALPGLEIGHES------APT 7259 Query: 1465 NFEVALLFLAIGMSVTPSGELD 1486 A L +++ + P GE D Sbjct: 7260 GTARADLTISLAERLRPDGEPD 7281 Score = 91.7 bits (226), Expect = 8e-16 Identities = 132/595 (22%), Positives = 209/595 (35%), Gaps = 70/595 (11%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 L+ QR +WF + + +YR+ ++ +H AV+ VV A+ D Sbjct: 11 LTTAQREIWFAEQRAGGPIP-----SYRIGECLE---IHGAVDPVVFERALRLVVDAADV 62 Query: 104 ------EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLR 157 EG V + + W L E + RP DL ++ Sbjct: 63 LHVRVVEGPDGPVQVERRDRDWELTTLDLSAEPDPRAAALDWSRRHLQRPIDLAHDRLFA 122 Query: 158 ITVIRTRADELVLLLVVHHICWDDDSWEVF---FGELSAAYND----LPINDPAAQFLSV 210 +I+ + V HH+ D + + GE AA + P+ P + ++ Sbjct: 123 YALIKLSDENFVWYQGYHHLVTDGFGYRLLSRRVGEACAALAEGLPSEPVVAPLREVVAH 182 Query: 211 EVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDF 270 ++ S+ + D +W L P + VR + G + + D Sbjct: 183 DLAYRSSGRAAEDRAHWTSHLAAPPDL--------TTPAGDPRAVVRSVDLGDVAGLADV 234 Query: 271 ARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTER---SGAAAGALGYFGNTLLLRI 327 R+ + L+AA + R TG D ++ + V+ R A ++ N + LR+ Sbjct: 235 GRRSGVTWTRALVAATALYAHRLTGERDVVLGLVVSGRPRGDALLADSIAVAANVVPLRL 294 Query: 328 TTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMR-- 385 R + V R A HQ + + R+ G+D L N+ Sbjct: 295 AVRPDTRWGDLVANTRREMTAALPHQRYRYEDLHRDL--------GVDALFHAVVNIMPF 346 Query: 386 KSAGGLALDGVVVRQLG--LGAVAAHL------PLSLTIALDPDDVSVEFEYQQQLSSVL 437 + A G A V L LG + L P A V E + + L Sbjct: 347 RPAAGFAGHPVTAHALSTSLGPTLSLLAWDDGKPCVEVHATADAPVEHRAEAHRARLAAL 406 Query: 438 VDQML-------VHYLQLVDKALAEPERP----LSSLDILGAGERDSVLAQSHGEL---- 482 V ++ + + L A A P +P ++ ++ G A+S Sbjct: 407 VANLVPITPDTPIGRVSLTPTAFALPSQPGPATVTPTGLVVPGPAAPPPAESATTPPADT 466 Query: 483 -----VEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGF 537 PA T V + LTY+EL RA RL+R G Sbjct: 467 TPPADTTTPAATTTPAELFAEQVATTPDAVAVVHGDTTLTYAELDVRAERLSRALHAHGI 526 Query: 538 GPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI 592 G E + L M S + A+LAVLK GAA P+DPA P RI L+ D RP V+ Sbjct: 527 GAEHFVALAMPRSADLATALLAVLKRGAACAPLDPAQPPARIADLLADIRPALVL 581 Score = 50.4 bits (119), Expect = 0.002 Identities = 80/353 (22%), Positives = 128/353 (36%), Gaps = 28/353 (7%) Query: 1095 LPLSHSQLAAWF-QYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFD 1153 +PL+ +Q WF + R G + + L G + L Sbjct: 9 VPLTTAQREIWFAEQRAGGPIPSYRIGECLEIHGAVDPVVFERALRLVVDAADVLHVRVV 68 Query: 1154 EHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL---RRHVFTP---ESGPLLQANLLV 1207 E P Q+ R +L + + D + L RRH+ P L L+ Sbjct: 69 EGPDGPVQVERRDRDWELTTLDLSAEP-DPRAAALDWSRRHLQRPIDLAHDRLFAYALIK 127 Query: 1208 LGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRN 1267 L + V HH+V+D ++ + A A + + + P++ + Sbjct: 128 LSDENFVWYQGYHHLVTDGFGYRLLSRRVGEACAALAEGLPSEPVVAPLR--EVVAHDLA 185 Query: 1268 TFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLA 1327 S + +W LA PD + A D PR + + SV A L + Sbjct: 186 YRSSGRAAEDRAHWTSHLAAPPDLTTPAGD---PRAVVR-------SVDLGDVAGLADVG 235 Query: 1328 ERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARV--EPATAQLVGLFANVVVLRTD 1385 R+G T AA A+ H+L G D+ LG V+ R + A + + ANVV LR Sbjct: 236 RRSGVTWTRALVAATALYAHRLTGERDVVLGLVVSGRPRGDALLADSIAVAANVVPLRLA 295 Query: 1386 LSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLN 1438 + D ++ +R + AL HQ E L R L + LF ++N Sbjct: 296 VRPDTRWGDLVANTRREMTAALPHQRYRYEDL------HRDLGVDALFHAVVN 342 Score = 46.2 bits (108), Expect = 0.040 Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 4/92 (4%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 ER L + E+L + + D+++FALGG S++A + S ALG+ +F T+A Sbjct: 3248 ERVLCELFTEVLGVAEVGADDDFFALGGHSLLATRLVSRVRSALGVELDLRALFGSPTVA 3307 Query: 1619 ELAAAVDAAN-GEPVVEADPPPAQEYTPMSAS 1649 LAA +D A+ P V + P P P+S++ Sbjct: 3308 GLAAVLDDADRARPAVTSAPRP--NVVPLSSA 3337 Score = 45.1 bits (105), Expect = 0.089 Identities = 31/91 (34%), Positives = 47/91 (51%), Gaps = 2/91 (2%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMT 1616 E ER L + E+L + + D ++FALGG S++A++ +A +LG+ A +F+ T Sbjct: 1139 ERERVLCGLFGEVLGVAAVAADADFFALGGHSLLAVRLVAAVRASLGVELGLADLFDAPT 1198 Query: 1617 IAELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 LA VDAA P P E P+S Sbjct: 1199 PEALALRVDAA-APARAPLRPRPRPERVPLS 1228 >tr|Q5YPH7|Q5YPH7_NOCFA Tax_Id=37329 SubName: Full=Putative non-ribosomal peptide synthetase;[Nocardia farcinica] Length = 8426 Score = 791 bits (2042), Expect = 0.0 Identities = 559/1525 (36%), Positives = 761/1525 (49%), Gaps = 122/1525 (8%) Query: 20 IAESGLAAEQSSDQPGICPG---ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLV 76 +AE AA + +P + +R LS Q R+W L +DP+ NI + RL G + Sbjct: 3907 LAERVRAAAGAPSRPPLAARPRPQRIPLSAAQTRIWLLNRLDPESPVYNIPLTIRLTGAL 3966 Query: 77 DEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQ- 135 D L TA+ DV+ARH LRT + D EG P+QV V DL + G Sbjct: 3967 DVPALGTALADVMARHESLRTVFPADAEG-PHQV----VRAPGPAPDLDPVRVEGDPATA 4021 Query: 136 IESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY 195 + AD F DL ELP+R + R ADE VL +VVHHI D S +L AY Sbjct: 4022 VLGFLADGF----DLRTELPVRARLFRLAADEHVLAVVVHHIAADGVSTAPLARDLMTAY 4077 Query: 196 N-----------DLPI----------------NDPAAQFLSVEVLQNSAAPSVADVGYWA 228 LP+ +DPA+ VL +A A++ A Sbjct: 4078 AARAAGAAPGWAPLPVQYADFALWQRETLGDPDDPAS------VLARQSAHWRAELAGLA 4131 Query: 229 ETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGV 288 L SG R L L + + D AR+ SPFMV+ AAY V Sbjct: 4132 PVLELPADRPRPPVASG-----RGATVEFALSTELTAAIADTARRHGVSPFMVVHAAYAV 4186 Query: 289 LVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCL 347 L+ R G +D + PV R+ AA L G F NT++LR + +F ++ VRE + Sbjct: 4187 LLARLAGTADVAIGTPVAGRAEAALDDLVGMFVNTVVLRTPVPAGQSFAELLHRVREIDV 4246 Query: 348 AGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVA 407 FA+ + +R+V + NP R + L + R L L G+ V L + Sbjct: 4247 RAFANADLPFERLVEDLNPVRSQAHAPIVQALLTYEHRDDTV-LRLPGLEVAPYPLDSGI 4305 Query: 408 AHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLV-----HYLQLVDKALAEPERPLSS 462 A L+L +A + + ++ L D+ V ++L+ A+A+P RP+ Sbjct: 4306 AQFDLALELAELATEAGTAVRAVLRYATDLFDEATVASFAERLIRLLSAAVADPARPVGD 4365 Query: 463 LDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELH 522 LD+L A ER VL + + A + L+Y+E Sbjct: 4366 LDLLAADERALVLRHWNDTAHPVAAPDDTLASLFERQVRRAPDAIALSFEGTSLSYAEFA 4425 Query: 523 RRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYL 582 RA RLARW + QG P + L M S++ +V M AV AG AY+PIDP +P ER++Y+ Sbjct: 4426 ARARRLARWLVSQGVAPGSAVALGMRRSVDLVVGMYAVTLAGGAYVPIDPEHPAERVEYV 4485 Query: 583 ITDARPQTVIGR---------PELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTS 633 + ARP V+ P++ V + +D P+ D++R PLRPGH AYV++TS Sbjct: 4486 LRTARPVCVLTAGADLSVGTAPQVRVDRLELSRFADGPIRDAERRAPLRPGHPAYVLFTS 4545 Query: 634 GSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQL 693 GSTGRPKGVAV+H AI + + + +D LQ + +FD S+ + F L +GA+L Sbjct: 4546 GSTGRPKGVAVAHAAIVNRLVWMQDRYGLRPDDVVLQKTPATFDVSVWEFFWPLQVGARL 4605 Query: 694 IVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPG 753 +V +PD D +Y+A L VT + LR V GEALP Sbjct: 4606 VVARPDGHRDPAYLARLTVDERVTTVHFVPSMLAVFLAEPAADR-TGLRRVFASGEALPA 4664 Query: 754 EVADRFAGYFDAELRNHYGPTEAVVCST-HMVVTGSHGARVVPIGVPNRNVYAYVLDEQL 812 +A R A + N YGPTEA V T H V GA VPIG P N VLD +L Sbjct: 4665 PIAQRARRVLGARVHNLYGPTEAAVDVTFHEVTDADTGA--VPIGRPVFNTRLLVLDARL 4722 Query: 813 HPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGEL 871 PVP V GELYL G+QLA GY+ RP LTA+RF+ADPF PG R+YRTGDLVR N GEL Sbjct: 4723 RPVPVGVPGELYLAGAQLALGYVARPDLTAERFVADPFGEPGDRMYRTGDLVRWNRDGEL 4782 Query: 872 EFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGP-MLAAYLVPAAAQV 930 E++GR D QVK+RG RIELGE+E+ +T P + V+ T G L YLV A Sbjct: 4783 EYLGRTDFQVKLRGLRIELGEIETALTALPGIEQAAVLVRGTAGGEDTLVGYLV--ATDP 4840 Query: 931 DLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATE 990 DL+ +RA AA +P YMVP AF V+ E+P+ SGKLDR ALP P + RYR PET TE Sbjct: 4841 DLDAVRAALAARLPAYMVPAAFVVLDELPVNSSGKLDRAALPDPV-FESARYRAPETETE 4899 Query: 991 RWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAG 1050 R + ++FA + GR +GA+D FF GG+SL A R VA++ A+ DL VR +FDAPT AG Sbjct: 4900 RLVAAVFADVLGRADIGADDDFFASGGNSLSATRAVARLGADLAADLPVRLLFDAPTVAG 4959 Query: 1051 LAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRI 1110 AAR A P++ P RP+ +PLS +Q WF R Sbjct: 4960 FAAR-----------------AAAFAATPRK--PALAPRPRPEHVPLSPAQQRMWFLNRF 5000 Query: 1111 EGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQ-IVHPSRTV 1169 + N+P+A+RF G RHE LRT + + +G+ +Q I+ P R Sbjct: 5001 DPTETVHNIPVAIRFTGELDRAALTAALAAVVDRHETLRTRYPDRDGIGHQQILPPGRVP 5060 Query: 1170 QLAVRAIDQDEFD--DVSTQLRRHVFTP---ESGPLLQANLLVLGPDTHVLLLIVHHIVS 1224 ++ E D D + L V TP + L+ L LG H+L L+VHHI + Sbjct: 5061 EIV-------ELDGADPAAALTEFVATPFDVTAEVPLRIGLARLGAREHLLALVVHHIAA 5113 Query: 1225 DHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELD 1279 D S+ + DL AY A+L AP W L + +ADYA+WQR + + +L Sbjct: 5114 DGFSMGPLARDLAAAYTAQLTGTAPDWPELRVHYADYALWQRELLGAEDDPDSPAAVQLG 5173 Query: 1280 YWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQ 1339 YWR+ L GLP ++ + DR RP V R V +P RA + +A R AT FM+ Sbjct: 5174 YWRETLRGLPAQLDLPADRPRPAVASHRAASVCVPLPDELRAGVDAVAARYEATPFMVVH 5233 Query: 1340 AALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGS 1399 AALAV+L +L G DIA+G+P+A R LVG+F N +VLRT + G T ++L Sbjct: 5234 AALAVLLARLSGTADIAVGAPIAGRGARGLDDLVGMFVNTLVLRTAVPGADTFDAVLRRV 5293 Query: 1400 RDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTV 1459 R+ LDA AH ++P ERLVE L+PPR+ SR+PLFQ L F ++ A V +L G V Sbjct: 5294 RERDLDAFAHADVPFERLVEVLDPPRSESRHPLFQVALFF--QNLAPVQLELPG---VVV 5348 Query: 1460 VPLPVNFEVALLFLAIGMSVTPSGE 1484 PV EV+ + VT +GE Sbjct: 5349 TEHPVEHEVS----RFDLQVTVAGE 5369 Score = 766 bits (1979), Expect = 0.0 Identities = 561/1527 (36%), Positives = 743/1527 (48%), Gaps = 104/1527 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDD-------VTLNICVAYRLAGLVDEDRLHTAVNDVVARH 92 E LS QRRMWFL + D NI VA RL G +D L A++D+VARH Sbjct: 727 EHIPLSPAQRRMWFLNRLGTDSGRDPAAGAVDNIPVALRLRGPLDAAALAAAMSDLVARH 786 Query: 93 AILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTN 152 ILRT Y TE P QV V P A E ++ + FD+ Sbjct: 787 EILRTVYP-QTETGPVQVIRPVHPVP------ALAPGAVAESELVETVQAIAIQGFDVAE 839 Query: 153 ELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPIN 201 E+P+R+ ++R ++ L+ VVHHI D S V +L AY LP+ Sbjct: 840 EIPMRVRLLRCGPEDHTLVFVVHHIAADGVSMGVLVRDLVTAYAARRDGHAPDWAPLPVQ 899 Query: 202 DPAAQFLSVEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRV 256 VL ++ P A + +W L A R Sbjct: 900 YADYALWQQRVLGDAQDPESALARQLDFWRAELAELPAQLDLLTDRPRPAVSTYRGASHA 959 Query: 257 RPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG-A 315 L AGL + ++ A + A+PFMV+ AA L+ R +G +D V PV R A Sbjct: 960 FALDAGLRADIDRVAARYGATPFMVVHAALAALLARLSGTADIAVGTPVAGRGEALLDDV 1019 Query: 316 LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM-GRDGM 374 +G F NTL+LR R TF V R+ L FAH+ + +++V NP R GR + Sbjct: 1020 VGMFVNTLVLRTEVRPAATFAELVAHARDRDLRAFAHRDIPFEQLVEALNPARSRGRHPL 1079 Query: 375 DLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVS---VEFEYQQ 431 + N+ A LAL G+ V QL A L LT++ DD EF Y Sbjct: 1080 FQVALFMQNIGPVA--LALPGLRVEQLDFDPGFAKFDLQLTLSEPLDDAGGYRAEFTYAT 1137 Query: 432 QL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTM 490 L + V + + +L+ ALA+PER L +D+L AGERD V+ S A Sbjct: 1138 DLFDAATVAEFAAKFDRLLRAALADPERVLGDIDVLDAGERDYVV-DSWNASGHKVAERF 1196 Query: 491 VKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANS 550 + D LTY+EL RANRLAR I G GPE ++ L M Sbjct: 1197 LHDGFDIQVRRTPDAIAVRADDGETLTYAELSARANRLARLLIAAGVGPESLVVLAMPRG 1256 Query: 551 IEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAA------ 604 +E +VAM AVL+AG AY+P+DPA+P ER+ +++ A P+ V+ VA A Sbjct: 1257 VELVVAMYAVLRAGGAYVPVDPAHPAERVGHILATAAPRVVLTTAAAGVAPAALPAGVPV 1316 Query: 605 --ADNSDLP------LSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 D DL ++D +R PL P + AYVI+TSGSTG+PKGV+VSH AI + Sbjct: 1317 HQVDELDLSGYAPTRIADHERA-PLHPDNPAYVIFTSGSTGKPKGVSVSHRAIVNQLAWM 1375 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGV 716 AE+ + D +LQ ++ +FD SL F+ L GA L + PD D Y+A+ I+ V Sbjct: 1376 HAEYRVRPGDVYLQKTAATFDVSLWGYFLPLRAGATLRLAAPDGHRDPRYLAETIAADQV 1435 Query: 717 TVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEA 776 T+ + LR V V GEALP E F DA L N YGPTEA Sbjct: 1436 TLTDFVPSMLAVFAAHARRGELDSLREVFVIGEALPPETVAAFHAVCDAGLHNLYGPTEA 1495 Query: 777 VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLG 836 V T+ VT + G +VPIG P N YVLD +LHP P V GELYL G QLARGY G Sbjct: 1496 AVSITYREVTAADGP-LVPIGEPEWNSQVYVLDARLHPAPIGVPGELYLAGDQLARGYHG 1554 Query: 837 RPTLTAQRFIADPFNPG-MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVES 895 R LTA RF+A+PF G R+YRTGDLVR + GEL ++GR D QVK RG RIEL E+E+ Sbjct: 1555 RVDLTADRFVANPFGRGGERMYRTGDLVRWSSDGELIYLGRVDFQVKFRGQRIELAEIET 1614 Query: 896 VITTHPAVRHCLVVAEETEAGP-----MLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVP 949 + P V E G L Y+V A A+VD++ +RA +P YMVP Sbjct: 1615 ALLAEPEVGQAAAALWSRERGSGEPGEHLVGYVVAAPGAEVDIDRLRAALTRRLPAYMVP 1674 Query: 950 GAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAE 1009 A + E P+ SGKLDRRALPAP + +R P +R + +FA++ G +R G + Sbjct: 1675 TALVELAEFPLNTSGKLDRRALPAPV-LRAGVFRAPVDRVQRLVAEVFAEVLGAERAGLD 1733 Query: 1010 DSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDN 1069 D FF LGG SL A ++ A++ + VRT+F+APT A A D L Sbjct: 1734 DDFFALGGSSLDATQVTARVGTALDARVPVRTLFEAPTVAAFA---------DAIRPLAG 1784 Query: 1070 LAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIE---GAREEFNMPLALRFE 1126 AAD RP + ARP R+PLS +Q WF R+E GA +N+P+ LR Sbjct: 1785 SAAD---------RPVLARRARPDRIPLSPAQQRLWFLNRVETQDGADSVYNLPVVLRLT 1835 Query: 1127 GPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAID--QDEFDDV 1184 G RHE+LRT F + E P Q V P+ V A+ I DE DD Sbjct: 1836 GELDIPALEHAVGDVLGRHESLRTVFPQDERGPCQAVLPAAEVGPALDLIPVTPDELDDA 1895 Query: 1185 STQLRRHVFTPESGPLLQANLLVLG-----PDTH---VLLLIVHHIVSDHASLEIVFDDL 1236 L R F S L A + +LG P H VL+ +VHHI +D S + DL Sbjct: 1896 VASLVRAGFDVTSE--LPARIALLGIERENPTEHAEYVLVFVVHHIAADALSAAPLVADL 1953 Query: 1237 IVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDE 1291 + AYRAR AP W LP+Q+ADY++WQ S + +LD+WR L G P + Sbjct: 1954 MRAYRARHAGAAPDWAELPVQYADYSLWQHELLGSPDRPGDLAADQLDFWRATLDGAPAQ 2013 Query: 1292 ISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGG 1351 + + TDR RP RG V ++ AA L LA R GAT FM+ AA A L +L G Sbjct: 2014 LPLPTDRPRPAQPTLRGAAVDLALDAAATEGLRALAARGGATLFMVVHAAFAATLARLSG 2073 Query: 1352 GTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQE 1411 DI +G+PV R + A LVG+F N +VLRT + D TL ++ R+ L A AH E Sbjct: 2074 TDDIVVGTPVGGRGDRALDALVGMFVNTLVLRTPIRLDATLAEVVAQVREVDLAAFAHPE 2133 Query: 1412 LPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALL 1471 LP E+LV+AL R+ +PLFQ ML+F D L G V LPV + A Sbjct: 2134 LPFEQLVDALVIDRSGGAHPLFQVMLSFGAADQPTAAFALPG---VRVEALPVPDDGAKF 2190 Query: 1472 FLAIGMSVTPSGELDVQVIANADLYEP 1498 L + ++ P G L + DL++P Sbjct: 2191 DLHLVLTEQPDGGLSGSLRYATDLFDP 2217 Score = 749 bits (1935), Expect = 0.0 Identities = 542/1520 (35%), Positives = 752/1520 (49%), Gaps = 101/1520 (6%) Query: 33 QPGICPG---ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVV 89 +P + P E LS Q+RMWFL DP + NI VA R G +D L A+ VV Sbjct: 4973 KPALAPRPRPEHVPLSPAQQRMWFLNRFDPTETVHNIPVAIRFTGELDRAALTAALAAVV 5032 Query: 90 ARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFD 149 RH LRT Y D +G +Q + R ++ L A + A PFD Sbjct: 5033 DRHETLRTRYP-DRDGIGHQ----QILPPGRVPEIVELDGADPAAALTEFVAT----PFD 5083 Query: 150 LTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DL 198 +T E+PLRI + R A E +L LVVHHI D S +L+AAY +L Sbjct: 5084 VTAEVPLRIGLARLGAREHLLALVVHHIAADGFSMGPLARDLAAAYTAQLTGTAPDWPEL 5143 Query: 199 PINDPAAQFLSVEVL---QNSAAPSVADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQ 253 ++ E+L + +P+ +GYW ETLR A RA Sbjct: 5144 RVHYADYALWQRELLGAEDDPDSPAAVQLGYWRETLRGLPAQLDLPADRPRPAVASHRAA 5203 Query: 254 RRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA 313 PLP L + V+ A + A+PFMV+ AA VL+ R +G +D V P+ R Sbjct: 5204 SVCVPLPDELRAGVDAVAARYEATPFMVVHAALAVLLARLSGTADIAVGAPIAGRGARGL 5263 Query: 314 GAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRD 372 L G F NTL+LR DTF + + VRE L FAH V +R+V +P R Sbjct: 5264 DDLVGMFVNTLVLRTAVPGADTFDAVLRRVRERDLDAFAHADVPFERLVEVLDPPRSESR 5323 Query: 373 GMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ 432 V L F + L L GVVV + + + L +T+A + ++ F Y Sbjct: 5324 HPLFQVALFFQ-NLAPVQLELPGVVVTEHPVEHEVSRFDLQVTVAGE----TLRFTYATD 5378 Query: 433 L-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMP-ATTM 490 L V + +L+L+ +A+ P+ +D+ G GE V+ + + P A + Sbjct: 5379 LFDESTVRGVADRFLRLLGAVVADQHVPVGDIDLFGPGELHRVVTEWNDSAHTTPLAELL 5438 Query: 491 VKXXXXXXXXXXXXXXXXXVSDE----AELTYSELHRRANRLARWFIGQGFGPEDIIGLR 546 + V D+ A L+Y EL RR N+LAR IG G GPE ++ L Sbjct: 5439 LDEFELQAAATPDDPAVIHVPDDGSAAAVLSYGELDRRGNQLARHLIGLGVGPESLVALA 5498 Query: 547 MANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDV------- 599 + S + +VAM AVLKAG AY+PIDP +P RI +++ A P ++ ++ + Sbjct: 5499 IRRSTDLVVAMYAVLKAGGAYVPIDPDHPPLRIAHVLDTAAPAALLVTTDVTLDYDGPVV 5558 Query: 600 -AERAAADN-SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFV 657 + A D +D P++ +R PL P + AYV++TSGSTG+PKGV+VSH AI + Sbjct: 5559 AVDTVALDGYADDPVAPEERRGPLHPDNPAYVLFTSGSTGKPKGVSVSHAAIVNQITWMQ 5618 Query: 658 AEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVT 717 + + + + D +LQ ++ +FD SL F+ L +GA +++ PD D Y+A+++ GVT Sbjct: 5619 SRYRLDSGDVYLQKTATTFDVSLWGYFLPLRVGATVVLASPDGHRDPGYLAEVMGAYGVT 5678 Query: 718 VXXXXXXXXXXXXXXXXXX----QWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGP 773 V LR V V GEALPGE F A + N YGP Sbjct: 5679 VTDFVPTMLAVFAGHVAESGQAAALAALRMVFVIGEALPGETVRAFTAISSAAVHNLYGP 5738 Query: 774 TEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARG 833 TEA V TH VTG G V PIG P N YVLD +L P V GELYL G QLARG Sbjct: 5739 TEAAVSITHREVTGETGRAVAPIGNPEWNSRVYVLDSRLRPTLPGVAGELYLAGVQLARG 5798 Query: 834 YLGRPTLTAQRFIADPFN-PGMRLYRTGDLVR---RNHCGELEFVGRADEQVKIRGFRIE 889 Y GRP LTA RF+A+PF G R+YRTGDLVR R EL ++GR D QVK RG RIE Sbjct: 5799 YHGRPALTADRFVANPFGAAGERMYRTGDLVRWETRGDTAELVYLGRTDFQVKFRGQRIE 5858 Query: 890 LGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQVD-----LEEIRAHTAAAVP 944 LGE+E+V+ P V A G L YL+ A D L RA A+P Sbjct: 5859 LGEIEAVLAAVPGV----AGAAARVLGEHLVGYLLVAPEAADDHDAVLARARAAAHEALP 5914 Query: 945 EYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQ 1004 YMVPGA + E P+ VSGKLDR ALP P YR P T ER + FA + G Sbjct: 5915 AYMVPGALLALDEFPLNVSGKLDRAALPEPV-FDGAAYRAPVTPAERLVAEAFATVLGVD 5973 Query: 1005 RVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFE 1064 R G +DSFF LGG+SL A R++A++ G + VR +F+ PT GLAA L Sbjct: 5974 RPGVDDSFFDLGGNSLSATRVLARLGERLGRRVPVRLLFEEPTVRGLAAAL--------- 6024 Query: 1065 LDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALR 1124 AD + P A P RP LPL+ Q WF R++ N+P+ALR Sbjct: 6025 ----TAGADAEAVVPLVAGP------RPPVLPLAPVQRGMWFLNRLDPESPAHNIPVALR 6074 Query: 1125 FEGPXXXXXXXXXXXXXXXRHEALRTNFD-EHEGVPYQIVHPSR--TVQLAVRAIDQDEF 1181 G RHEALRT + + +GV +Q+V P+ V+LA+ A+D + Sbjct: 6075 MTGELDEDWLTAAFADVVARHEALRTVYPADADGVGHQVVLPAEDAPVRLAIEAVDPAQV 6134 Query: 1182 DDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYR 1241 D + F + ++A LL + VL+ ++HH+ +D S+ + DL+VAY Sbjct: 6135 DARIAEFLADGFDVTAEVPVRAVLLRESATSRVLVAVLHHLAADGFSMRPLLRDLLVAYM 6194 Query: 1242 ARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARP 1301 +R P W L Q+ADYA+WQ ++ EL YWR+ L GLPD++++ TDR RP Sbjct: 6195 SRALRTEPAWPPLHAQYADYALWQSAAADAA-ADRELAYWREQLRGLPDDLALPTDRPRP 6253 Query: 1302 RVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPV 1361 V KRG V+ + A A + LA+R+ AT FM+ AALAV+L +L G TD+A+G+PV Sbjct: 6254 AVASKRGATVRARLGAPVAARIRALAQRHEATPFMVVYAALAVLLARLSGATDVAVGTPV 6313 Query: 1362 AARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEAL 1421 A R A LVG+F N + LR+ + +++ S+ T L A +H +P ER+VE L Sbjct: 6314 AGRGAAALDDLVGMFVNTLTLRSRPEPGRSFDALIEESKTTALQAFSHATVPFERVVEDL 6373 Query: 1422 NPPRALSRNPLFQNMLNFR--GEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSV 1479 P +R+PLF +LN++ G D VP + P+ VA L G++ Sbjct: 6374 GVPADPARHPLFTVVLNYQNLGTDTFAVP-------GLELAPVEFAETVARFDLQFGVAD 6426 Query: 1480 TP--SGELDVQVIANADLYE 1497 P G L +++ DL++ Sbjct: 6427 APDADGHLALELEYATDLFD 6446 Score = 740 bits (1911), Expect = 0.0 Identities = 530/1454 (36%), Positives = 717/1454 (49%), Gaps = 80/1454 (5%) Query: 40 ERYRLSDGQRRMWFL---QTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILR 96 +R LS Q+R+WFL +T D D N+ V RL G +D L AV DV+ RH LR Sbjct: 1799 DRIPLSPAQQRLWFLNRVETQDGADSVYNLPVVLRLTGELDIPALEHAVGDVLGRHESLR 1858 Query: 97 TTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPL 156 T + D G P Q EVG + + P+ +++ A FD+T+ELP Sbjct: 1859 TVFPQDERG-PCQAVLPAAEVGPALDLIPVTPD-----ELDDAVASLVRAGFDVTSELPA 1912 Query: 157 RITVIR------TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLP 199 RI ++ T E VL+ VVHHI D S +L AY +LP Sbjct: 1913 RIALLGIERENPTEHAEYVLVFVVHHIAADALSAAPLVADLMRAYRARHAGAAPDWAELP 1972 Query: 200 INDPAAQFLSVEVLQNSAAPS--VAD-VGYWAETL--RXXXXXXXXXGVSGANPCRRAQR 254 + E+L + P AD + +W TL A P R Sbjct: 1973 VQYADYSLWQHELLGSPDRPGDLAADQLDFWRATLDGAPAQLPLPTDRPRPAQPTLRGAA 2032 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 L A + A + A+ FMV+ AA+ + R +G D +V PV R A Sbjct: 2033 VDLALDAAATEGLRALAARGGATLFMVVHAAFAATLARLSGTDDIVVGTPVGGRGDRALD 2092 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 AL G F NTL+LR R T V +VRE LA FAH + +++V +R G Sbjct: 2093 ALVGMFVNTLVLRTPIRLDATLAEVVAQVREVDLAAFAHPELPFEQLVDALVIDRSGGAH 2152 Query: 374 MDLLVRLGFNMR-KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD-VSVEFEYQQ 431 V L F + AL GV V L + A L L + PD +S Y Sbjct: 2153 PLFQVMLSFGAADQPTAAFALPGVRVEALPVPDDGAKFDLHLVLTEQPDGGLSGSLRYAT 2212 Query: 432 QL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTM 490 L + + +++ A P+ + ++++L A ER VL + + + A Sbjct: 2213 DLFDPATAATLAARFTRVLGAAATAPDTAVGAVELLDAEERALVLHRWN-DTAHALAQDG 2271 Query: 491 VKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANS 550 +D LTY+E R NRLARW IGQG GP+ ++ L M S Sbjct: 2272 TLADLFARQAARTPDRPALTADGVTLTYAEFAARVNRLARWLIGQGVGPDALVALGMRRS 2331 Query: 551 IEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-GRPELDV-AERAAADNS 608 I+ +V M AV AG YLP+DP P ER +++ A P V+ +LD+ + D Sbjct: 2332 IDLVVGMYAVTVAGGGYLPLDPDLPAERTRHILDTAIPVAVLTAGTDLDLPVAQIRIDRL 2391 Query: 609 DL------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW-T 661 DL P+ D++R PLR H AYV++TSGSTGRPKGVAV+H A+ ++ + Sbjct: 2392 DLERYPTTPVRDAERRAPLRAAHTAYVLFTSGSTGRPKGVAVAHAAVVNRLRWMQEAYIA 2451 Query: 662 MTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXX 721 + +D LQ + V+FD S+ + F L +GA+L++ PD D Y+A++I GVTV Sbjct: 2452 LRPDDVLLQKTPVTFDVSVPEFFWPLQVGARLVLATPDGHRDPRYLAEVIRAEGVTVAHF 2511 Query: 722 XXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCST 781 R LRH+ GEALP A R A + N YGPTEA V T Sbjct: 2512 VPSMLAVFLAEAASGDTR-LRHLLCSGEALPAATAQRARELTGARVHNLYGPTEAAVEVT 2570 Query: 782 HMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLT 841 VT + VP+G P N AYVLD +L PVP V GELYL G+QLARGYLGR LT Sbjct: 2571 CHEVTDAD-TDTVPMGRPVWNTRAYVLDARLRPVPVGVPGELYLAGAQLARGYLGRADLT 2629 Query: 842 AQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 RF+ADPF+ PG R+YRTGDLVR N GELE++GR D QVK+RG RIELGE+E+ + Sbjct: 2630 GDRFVADPFDEPGDRMYRTGDLVRWNRDGELEYLGRTDFQVKLRGLRIELGEIETALLAV 2689 Query: 901 PAVRHCLV-VAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIP 959 P V V V ++ GP L AY+V V E +RA A +P YMVPG + + +P Sbjct: 2690 PGVEQAAVLVRDDHGTGPRLVAYVV-GVEPVPAEGLRAELARRLPGYMVPGVYVALDALP 2748 Query: 960 MTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHS 1019 + SGKLDR ALPAP P+AT +R P A E + IFA L G VGA D FF LGG+S Sbjct: 2749 LNASGKLDRAALPAPAPVATA-FRPPTGAAETLVAGIFADLLGHPAVGAGDDFFALGGNS 2807 Query: 1020 LLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDP 1079 L+A +L A++ A GV + VR +FDAPT A LA R+V DL Sbjct: 2808 LIATQLAARLTAARGVPVPVRAVFDAPTVAELA-RVVGAPAESAAPDL------------ 2854 Query: 1080 KRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 P AR +PLS +Q WF R + + +P ALR G Sbjct: 2855 ----PPLTGGARLDPVPLSIAQQRMWFLNRFDNRGGGYQIPFALRLSGALNVPALDAAIA 2910 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIVHPS--RTVQLAVRAIDQDEFDDVSTQLRRHVFTPES 1197 RHE LRT + E +G +Q+V P+ R V L R + E ++ F + Sbjct: 2911 DVIARHETLRTLYPEQDGAAHQVVLPAGTRLVDLVARPVRAAELPELVAAAASTPFDVTA 2970 Query: 1198 GPLLQANLLVL----GPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDI 1253 ++ LL + GP+ HVLL +VHHI +D S + DL AY AR AP W Sbjct: 2971 EVPVRVKLLEVRDAPGPE-HVLLFVVHHIAADGWSFAPLTRDLAAAYVARCAGVAPAWAP 3029 Query: 1254 LPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRG 1308 LP+Q+ADYA WQR + + +L YW + LAGLPD +++ DR RP V RG Sbjct: 3030 LPVQYADYACWQRRALGAPDEPGSVLADQLRYWTEQLAGLPDVLTLPVDRPRPAVATGRG 3089 Query: 1309 EVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPA 1368 V + AA + +LA + AT FM+ AALA +L +L D+ LG+PVA R + A Sbjct: 3090 GAVTGHLDAALHRGIVELAAAHRATPFMVLHAALAALLSRLAVTDDVVLGAPVAGRGDAA 3149 Query: 1369 TAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALS 1428 +LVG+F N +VLRT + D L ++ RDT L A H +P E+LV+ALNP R+ + Sbjct: 3150 LDELVGMFVNTLVLRTRVRPDAPLAELIDTVRDTDLAAFDHALVPFEQLVDALNPARSQA 3209 Query: 1429 RNPLFQNMLNFRGE 1442 +PL+Q L + + Sbjct: 3210 HSPLYQVALTLQNQ 3223 Score = 728 bits (1878), Expect = 0.0 Identities = 526/1486 (35%), Positives = 748/1486 (50%), Gaps = 111/1486 (7%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 L+ QR MWFL +DP+ NI VA R+ G +DED L A DVVARH LRT Y D Sbjct: 6047 LAPVQRGMWFLNRLDPESPAHNIPVALRMTGELDEDWLTAAFADVVARHEALRTVYPADA 6106 Query: 104 EGEPYQVF--SDDVEVGWRREDLTRLP-EAGHERQIESLAADEFGRPFDLTNELPLRITV 160 +G +QV ++D V RL EA Q+++ A+ FD+T E+P+R + Sbjct: 6107 DGVGHQVVLPAEDAPV--------RLAIEAVDPAQVDARIAEFLADGFDVTAEVPVRAVL 6158 Query: 161 IRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPIN-DPA-----AQFLSVEVLQ 214 +R A VL+ V+HH+ D S +L AY + +PA AQ+ + Q Sbjct: 6159 LRESATSRVLVAVLHHLAADGFSMRPLLRDLLVAYMSRALRTEPAWPPLHAQYADYALWQ 6218 Query: 215 NSAAPSVAD--VGYWAETLRXXXXXXXXXGVSGANPCRRAQR----RVRPLPAGLFSRVE 268 ++AA + AD + YW E LR P ++R R R L A + +R+ Sbjct: 6219 SAAADAAADRELAYWREQLRGLPDDLALP-TDRPRPAVASKRGATVRAR-LGAPVAARIR 6276 Query: 269 DFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLLRI 327 A++ A+PFMV+ AA VL+ R +GA+D V PV R AA L G F NTL LR Sbjct: 6277 ALAQRHEATPFMVVYAALAVLLARLSGATDVAVGTPVAGRGAAALDDLVGMFVNTLTLRS 6336 Query: 328 TTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREAN-PERMGRDGMDLLVRLGFNMRK 386 +F + + E + T L F+H +V +RVV + P R + +V N+ Sbjct: 6337 RPEPGRSFDALIEESKTTALQAFSHATVPFERVVEDLGVPADPARHPLFTVVLNYQNLGT 6396 Query: 387 SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPD---DVSVEFEYQQQL-SSVLVDQML 442 A+ G+ + + A L +A PD +++E EY L + +L Sbjct: 6397 DT--FAVPGLELAPVEFAETVARFDLQFGVADAPDADGHLALELEYATDLFDAATAAALL 6454 Query: 443 VHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXX 502 + +L+ A P+RP+ ++L GER ++L +S + TM+ Sbjct: 6455 RRFGRLLGALTAAPDRPIGDAELLAPGERAALLGRSGPPVRPDTLATML-----VTAAAA 6509 Query: 503 XXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLK 562 V + +LTY L +++RLAR IGQG G EDI+ L + S E+ +A+ AV K Sbjct: 6510 NPDGIAVVCGDRQLTYRALDEQSSRLARMLIGQGIGAEDIVALAIPRSAEYQLALWAVAK 6569 Query: 563 AGAAYLPIDPAYPDERIDYLITDARPQTVI-------GRPE------LDVAERAAA--DN 607 GAA++P+DP YP ERI +++TD+ + G P LD A AA Sbjct: 6570 TGAAFVPVDPTYPAERIAHMLTDSGAALGLTVERARAGLPGDTEWLVLDAATTAARLRHT 6629 Query: 608 SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDR 667 S P+S + +RP+R A++IYTSGSTG PKG V+H+ IA + +TA R Sbjct: 6630 SAAPVSPGELVRPVRTDDAAWMIYTSGSTGLPKGALVTHNGIAGVAYTQRDRYDVTARTR 6689 Query: 668 WLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXX 727 L +S SFDAS+ ++ + + L++ P+ F + +L++R V+ Sbjct: 6690 VLGVASPSFDASMLELLLAVVAAGTLVIAPPEVFAGAE-LTELMARERVS----HAFITP 6744 Query: 728 XXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTG 787 + H+ +GGEA E +A A N YGPTE + +T V Sbjct: 6745 SVLRTLDPARLPDFTHLIIGGEAFGTETVAAWARDGRAVF-NGYGPTETTIVAT--VSPP 6801 Query: 788 SHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIA 847 R V +GVP + A VLD +L PVP V GELYL G LARGY RP LTA RF+A Sbjct: 6802 LRPDRPVELGVPLAGMSAVVLDARLRPVPAGVPGELYLRGHGLARGYHARPGLTAGRFVA 6861 Query: 848 DPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHC 906 DP P G RLYRTGDL G L ++GR D QVK+RG RIELGE+++V+ HP+VR Sbjct: 6862 DPHGPAGGRLYRTGDLACWTADGALRYLGRGDHQVKVRGLRIELGEIDTVLAAHPSVRAA 6921 Query: 907 LVVAEETEAGPM-LAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSG 964 + V + L +Y+V A + VD + AH A A+P YMVP A V+ +P+T G Sbjct: 6922 VTVGHAVAGEDVALVSYVVAAQGEIVDTAALLAHAARALPPYMVPAAVTVLDRLPLTPVG 6981 Query: 965 KLDRRALPAPTPIATRRYREPETATERWICSIFAQLFG--RQRVGAEDSFFGLGGHSLLA 1022 KLDR ALPAP +R PETA +R + ++FA++ G RVG +D FF GG+SL A Sbjct: 6982 KLDRAALPAPH-FRAATFRAPETAAQRAVAAVFAEVLGLPADRVGLDDDFFARGGNSLTA 7040 Query: 1023 ARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRA 1082 +L A++ A V + VRT+F+ T A LA D LA P+ Sbjct: 7041 TQLAARLGAALSVTVGVRTVFEHATVAALA---------------DALAGAGSAHGPR-- 7083 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 V +PLS +Q WF R + +N+PLA+R G Sbjct: 7084 ---LVAREHDGPVPLSLAQQRMWFLNRFDHQSTAYNIPLAVRLTGELDVAALGAAVADVV 7140 Query: 1143 XRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV---FTPESGP 1199 RHE LRT + E +G P Q+V P R DD+ T + V F + P Sbjct: 7141 ARHEVLRTVYPEQDGAPVQVVLPVRRADAPSLTAIPVALDDLRTAVVDFVSAGFDVTAAP 7200 Query: 1200 LLQANLLV----LGPDT-------HVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNA 1248 ++A L PD HVL++++HHI +D +SL + D++VAY AR + A Sbjct: 7201 PVRATLFRPVADADPDAGAVPAREHVLVVVMHHIAADGSSLVPLARDVMVAYAARKRGLA 7260 Query: 1249 PQWDILPIQFADYAVWQRNTFESNWGQT-----ELDYWRDALAGLPDEISVATDRARPRV 1303 P W LP+Q+ADYA+WQR+ + +L +W D LAGLP E+ + TDR RP V Sbjct: 7261 PDWAPLPVQYADYAIWQRDVLGAEDDPDSLIARQLRFWLDTLAGLPAELPLPTDRPRPAV 7320 Query: 1304 LGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAA 1363 RG V F+V AA L +LA +GAT FM+ AA AV+L +L G TDIA+G+PVA Sbjct: 7321 ASTRGRHVDFTVDAATHTRLVELARAHGATPFMVVHAAFAVLLARLSGTTDIAVGTPVAG 7380 Query: 1364 RVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNP 1423 R +VG+F N +VLRT++ + ++L R L A AH ++P ERLVE +NP Sbjct: 7381 RGAAELDDVVGMFVNTLVLRTEVEPGASFTALLDRVRAADLAAFAHADVPFERLVEVVNP 7440 Query: 1424 PRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVA 1469 R+ +R+PLFQ +F + A +L G T P+ V+ EV+ Sbjct: 7441 ERSTARHPLFQVGFSFHNQ--ADADLELDG---ITASPVEVDTEVS 7481 Score = 717 bits (1852), Expect = 0.0 Identities = 531/1514 (35%), Positives = 742/1514 (49%), Gaps = 101/1514 (6%) Query: 24 GLAAEQSS-DQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 G AE ++ D P + G R LS Q+RMWFL D I A RL+G ++ Sbjct: 2844 GAPAESAAPDLPPLTGGARLDPVPLSIAQQRMWFLNRFDNRGGGYQIPFALRLSGALNVP 2903 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 L A+ DV+ARH LRT Y + +G +QV + G R DL P E + L Sbjct: 2904 ALDAAIADVIARHETLRTLYP-EQDGAAHQVV---LPAGTRLVDLVARPVRAAE--LPEL 2957 Query: 140 AADEFGRPFDLTNELPLRITVIRTR---ADELVLLLVVHHICWDDDSWEVFFGELSAAY- 195 A PFD+T E+P+R+ ++ R E VLL VVHHI D S+ +L+AAY Sbjct: 2958 VAAAASTPFDVTAEVPVRVKLLEVRDAPGPEHVLLFVVHHIAADGWSFAPLTRDLAAAYV 3017 Query: 196 ----NDLPINDPA-AQFLSVEVLQNSAAPSVADVG--------YWAETLRXXXXXXXXXG 242 P P Q+ Q A + + G YW E L Sbjct: 3018 ARCAGVAPAWAPLPVQYADYACWQRRALGAPDEPGSVLADQLRYWTEQLAGLPDVLTLP- 3076 Query: 243 VSGANPCRRAQRR---VRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDF 299 V P R L A L + + A A+PFMVL AA L+ R D Sbjct: 3077 VDRPRPAVATGRGGAVTGHLDAALHRGIVELAAAHRATPFMVLHAALAALLSRLAVTDDV 3136 Query: 300 LVSVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGID 358 ++ PV R AA L G F NTL+LR R ++ VR+T LA F H V + Sbjct: 3137 VLGAPVAGRGDAALDELVGMFVNTLVLRTRVRPDAPLAELIDTVRDTDLAAFDHALVPFE 3196 Query: 359 RVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPL--SLTI 416 ++V NP R V L ++A + L + + L +G + L +LT Sbjct: 3197 QLVDALNPARSQAHSPLYQVALTLQ-NQAAPQVRLHRLEITALEVGPAPIQVDLDWTLTD 3255 Query: 417 ALD----PDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGER 471 D P + V Y L V L + +++ + + + ++++ ER Sbjct: 3256 RYDAEGAPAGIDVYLHYALDLFDEPTVTGFLAGFERVLRAMVRDARTVVGDVELMSVAER 3315 Query: 472 DSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAEL-TYSELHRRANRLAR 530 +LA + +PA T+ V+ AE TY+E R NRLA Sbjct: 3316 GMLLADRNATAHRLPAETL---DDLLTTRVAADPDGHAVTVGAETRTYTEFAERVNRLAH 3372 Query: 531 WFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQT 590 IG G GPE ++GL ++ +VAM A+++AG AYLP+DPA+P +R+ ++ A+P Sbjct: 3373 HLIGAGVGPERVVGLVAHRGLDMLVAMYAIVRAGGAYLPLDPAHPADRLAQIVESAQPAL 3432 Query: 591 VI----------GRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPK 640 V+ G P L +A+ AD P++D+DR LRP + AYV++TSGSTGRPK Sbjct: 3433 VLVPVGADLPPLGVPVLRMADLDLADAPARPVTDADRTAALRPDNTAYVLFTSGSTGRPK 3492 Query: 641 GVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDA 700 GVAV+H AI ++ + +T DR LQ + ++FD S+ + F+ + +GA L++ P A Sbjct: 3493 GVAVTHRAIMNQLRWLEHRYQVTGADRILQRAPLTFDVSVWECFLPVAVGAPLVIAAPGA 3552 Query: 701 FGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFA 760 D++ ADL+ +T+ RH+ GGEAL ++ Sbjct: 3553 HLDLAAFADLLREHRITIAEYVPSVLAALIAEGMGDALASFRHLHCGGEALTPDLLTALR 3612 Query: 761 GYFDAELRNHYGPTEAVVCSTHMVVTGSHGA--RVVPIGVPNRNVYAYVLDEQLHPVPDQ 818 G FD + N YGPTEA + + + T + A R V IG P N YVLD +L PVP Sbjct: 3613 GVFDGAVHNAYGPTEAAISAVYHEFTDADVAQGRDVAIGRPCWNTRVYVLDTRLRPVPIG 3672 Query: 819 VIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRA 877 V GELYL G+QLARGY RP TA+RF+ADPF PG +YRTGDLVR N G+L ++GR Sbjct: 3673 VPGELYLAGNQLARGYHRRPGPTAERFVADPFGVPGSLMYRTGDLVRWNRDGDLIYLGRN 3732 Query: 878 DEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYL----VPAAAQVDL 932 D QVK+RG RIELGE+E+ + P V + V AG L Y+ + AAA +D+ Sbjct: 3733 DFQVKLRGQRIELGEIEAALAAVPGVANAAVRVVADSAGRDALVGYVSGDDLSAAAVLDV 3792 Query: 933 EEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPT-PIATRRYREPETATER 991 R +P YMVP V+ E+P+T GKLDR ALP P AT YR P E Sbjct: 3793 LRDR------LPGYMVPAHLVVLAEMPLTTVGKLDRAALPRPEFTAATTAYRAPREGAET 3846 Query: 992 WICSIFAQLFGRQ-RVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAG 1050 + ++ A+L G RVGA+D FF LGG+SLLA RLVA+ + GVDLTVR +F+APT A Sbjct: 3847 VLATLIAELLGGGVRVGADDDFFTLGGNSLLAMRLVARAGSALGVDLTVREVFEAPTVAQ 3906 Query: 1051 LAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRI 1110 LA R+ AA P ARP RPQR+PLS +Q W R+ Sbjct: 3907 LAERV-------------RAAAGAPSRPPLAARP------RPQRIPLSAAQTRIWLLNRL 3947 Query: 1111 EGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVH-PSRTV 1169 + +N+PL +R G RHE+LRT F P+Q+V P Sbjct: 3948 DPESPVYNIPLTIRLTGALDVPALGTALADVMARHESLRTVFPADAEGPHQVVRAPGPAP 4007 Query: 1170 QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASL 1229 L ++ D V L P+ +A L L D HVL ++VHHI +D S Sbjct: 4008 DLDPVRVEGDPATAVLGFLADGFDLRTELPV-RARLFRLAADEHVLAVVVHHIAADGVST 4066 Query: 1230 EIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDA 1284 + DL+ AY AR AP W LP+Q+AD+A+WQR T ++ + +WR Sbjct: 4067 APLARDLMTAYAARAAGAAPGWAPLPVQYADFALWQRETLGDPDDPASVLARQSAHWRAE 4126 Query: 1285 LAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAV 1344 LAGL + + DR RP V RG V+F++ AA+ A R+G + FM+ AA AV Sbjct: 4127 LAGLAPVLELPADRPRPPVASGRGATVEFALSTELTAAIADTARRHGVSPFMVVHAAYAV 4186 Query: 1345 VLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVL 1404 +L +L G D+A+G+PVA R E A LVG+F N VVLRT + + +L R+ + Sbjct: 4187 LLARLAGTADVAIGTPVAGRAEAALDDLVGMFVNTVVLRTPVPAGQSFAELLHRVREIDV 4246 Query: 1405 DALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPV 1464 A A+ +LP ERLVE LNP R+ + P+ Q +L + D ++ L G V P P+ Sbjct: 4247 RAFANADLPFERLVEDLNPVRSQAHAPIVQALLTYEHRDDTVL--RLPG---LEVAPYPL 4301 Query: 1465 NFEVALLFLAIGMS 1478 + +A LA+ ++ Sbjct: 4302 DSGIAQFDLALELA 4315 Score = 610 bits (1574), Expect = e-172 Identities = 383/955 (40%), Positives = 513/955 (53%), Gaps = 56/955 (5%) Query: 512 DEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPID 571 ++ LTY+E RA LAR + G GPE ++GL SIE +V M A+ KAG Y+PID Sbjct: 151 EDITLTYAEFDARAEALARHLVRCGVGPETLVGLAARRSIELMVGMYAIHKAGGGYVPID 210 Query: 572 PAYPDERIDYLITDARPQTVIGRPELDVAERAAA------DNSDLPLSDSDRLRPL---R 622 P +P ERI Y++ A P V+ + A A + P + L PL Sbjct: 211 PEHPAERIAYVLDTAAPVLVLTTTADEPAGLGDARVLRIDEFEAAPPAAEPELAPLPGPH 270 Query: 623 PGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLAD 682 P +AYVI+TSGSTGRPKGVAVSH ++ +++ M +D +Q + +FD S+ + Sbjct: 271 PDTVAYVIFTSGSTGRPKGVAVSHRSVMANLRWRQRLHPMRPDDVVIQKTPFTFDVSVWE 330 Query: 683 IFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXX--QWRQ 740 F L +GA+L + +PD D +Y+ ++ RGVT+ Sbjct: 331 FFWPLQVGARLAIARPDGHRDPAYLVRFLAERGVTIAHFVPSMLAMFVAELASSGVALDA 390 Query: 741 LRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPN 800 LR V GEALP A A L+N YGPTEA V T VT + VPIG Sbjct: 391 LRMVVASGEALPAATAAALRDVSGATLQNTYGPTEATVDVTAHEVTAADTV-TVPIGTVA 449 Query: 801 RNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRT 859 + VLDE L PVP V+GELYL G QLARGY+ RP LTA+RF+A+P PG R+YRT Sbjct: 450 DDNELLVLDESLRPVPTGVVGELYLAGVQLARGYVARPGLTAERFVANPHGAPGERMYRT 509 Query: 860 GDLVRRNHCG-----ELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE 914 GDLVR ELE++GR D QVK+RG RIELGEVE+ + V VV + Sbjct: 510 GDLVRWGGGADGGPLELEYLGRIDFQVKLRGLRIELGEVEAALLRSQQVAQAAVVVRQHA 569 Query: 915 AGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAP 974 G L Y+VPA VD + A +PEYMVP V+ E+P+ +GKLDR ALP P Sbjct: 570 GGDHLVGYVVPAGGPVDPAAVLAVAREHLPEYMVPALVQVLDELPVNANGKLDRAALPEP 629 Query: 975 T-PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEF 1033 A YREPETA E + ++FA+L G RVGA+D+FF LGG+SLLA R +A++ A Sbjct: 630 DFGAAAGEYREPETAAEHAVAAVFAELLGVDRVGADDNFFALGGNSLLATRAIARVAAAL 689 Query: 1034 GVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQ 1093 GV + VR FD PT A LAA L A ARP RP+ Sbjct: 690 GVTIDVRDFFDRPTVAALAA-------------LSGTA---------EARPPLTAQPRPE 727 Query: 1094 RLPLSHSQLAAWFQYRI-------EGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHE 1146 +PLS +Q WF R+ A N+P+ALR GP RHE Sbjct: 728 HIPLSPAQRRMWFLNRLGTDSGRDPAAGAVDNIPVALRLRGPLDAAALAAAMSDLVARHE 787 Query: 1147 ALRTNFDEHEGVPYQIVHPSRTVQ-LAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANL 1205 LRT + + E P Q++ P V LA A+ + E + + F ++ L Sbjct: 788 ILRTVYPQTETGPVQVIRPVHPVPALAPGAVAESELVETVQAIAIQGFDVAEEIPMRVRL 847 Query: 1206 LVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQ 1265 L GP+ H L+ +VHHI +D S+ ++ DL+ AY AR +AP W LP+Q+ADYA+WQ Sbjct: 848 LRCGPEDHTLVFVVHHIAADGVSMGVLVRDLVTAYAARRDGHAPDWAPLPVQYADYALWQ 907 Query: 1266 RNTF------ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 + ES + +LD+WR LA LP ++ + TDR RP V RG F++ A Sbjct: 908 QRVLGDAQDPESALAR-QLDFWRAELAELPAQLDLLTDRPRPAVSTYRGASHAFALDAGL 966 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 RA + ++A R GAT FM+ AALA +L +L G DIA+G+PVA R E +VG+F N Sbjct: 967 RADIDRVAARYGATPFMVVHAALAALLARLSGTADIAVGTPVAGRGEALLDDVVGMFVNT 1026 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQ 1434 +VLRT++ T ++ +RD L A AH+++P E+LVEALNP R+ R+PLFQ Sbjct: 1027 LVLRTEVRPAATFAELVAHARDRDLRAFAHRDIPFEQLVEALNPARSRGRHPLFQ 1081 Score = 522 bits (1344), Expect = e-145 Identities = 376/1066 (35%), Positives = 515/1066 (48%), Gaps = 67/1066 (6%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+RMWFL D NI +A RL G +D L AV DVVARH +LRT Y + Sbjct: 7095 LSLAQQRMWFLNRFDHQSTAYNIPLAVRLTGELDVAALGAAVADVVARHEVLRTVYP-EQ 7153 Query: 104 EGEPYQVFSDDVEVGWRRED---LTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITV 160 +G P QV + RR D LT +P A + + + D FD+T P+R T+ Sbjct: 7154 DGAPVQVV-----LPVRRADAPSLTAIPVALDD--LRTAVVDFVSAGFDVTAAPPVRATL 7206 Query: 161 IRTRAD-----------ELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DL 198 R AD E VL++V+HHI D S ++ AY L Sbjct: 7207 FRPVADADPDAGAVPAREHVLVVVMHHIAADGSSLVPLARDVMVAYAARKRGLAPDWAPL 7266 Query: 199 PINDPAAQFLSVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQ 253 P+ +VL P + +W +TL A R + Sbjct: 7267 PVQYADYAIWQRDVLGAEDDPDSLIARQLRFWLDTLAGLPAELPLPTDRPRPAVASTRGR 7326 Query: 254 RRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA 313 + A +R+ + AR A+PFMV+ AA+ VL+ R +G +D V PV R A Sbjct: 7327 HVDFTVDAATHTRLVELARAHGATPFMVVHAAFAVLLARLSGTTDIAVGTPVAGRGAAEL 7386 Query: 314 G-ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRD 372 +G F NTL+LR +FT+ ++ VR LA FAH V +R+V NPER Sbjct: 7387 DDVVGMFVNTLVLRTEVEPGASFTALLDRVRAADLAAFAHADVPFERLVEVVNPERS--T 7444 Query: 373 GMDLLVRLGFNMRKSAGG-LALDGVVVRQLGLGAVAAHLPLSLTI--ALDPDDVSVEFEY 429 L ++GF+ A L LDG+ + + + L L + D D Sbjct: 7445 ARHPLFQVGFSFHNQADADLELDGITASPVEVDTEVSQFDLHLVVNDRSDTDGTPRGLAA 7504 Query: 430 QQQLSSVLVDQMLV-----HYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVE 484 ++ L D+ V +L+ A P+ P+ L +L A E + VL + + Sbjct: 7505 ALTYATALFDEATVAGFAGRLQRLLAAVCAAPDLPVGDLPLLDAAETERVLRTWNQP--D 7562 Query: 485 MPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIG 544 T V + LTY E NRLAR IG+G GPE ++ Sbjct: 7563 RTCATGALAAGFHAQAARTPQHIAVVEGDRSLTYGEFAAAVNRLARVLIGRGVGPESLVA 7622 Query: 545 LRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR------PE-- 596 L + S E +VAM AVL AGA Y+P+DPA+P ER ++ A P+ V+ PE Sbjct: 7623 LAIPRSTELLVAMYAVLTAGAGYVPLDPAHPLERTTAVLAAADPELVLVSTRAPMLPERV 7682 Query: 597 --LDVAERAAADNSDLP---LSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAE 651 L++ A +D+P + + +RP+ P AYVI+TSGSTG PKGV V A+ Sbjct: 7683 SGLEIVLDIAGIGTDVPAHPVRPYELVRPVHPADTAYVIFTSGSTGAPKGVVVPQAAVTH 7742 Query: 652 HVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLI 711 ++ +E+ + A+D L +S +FD S+ + + GA+L++ A D + DL+ Sbjct: 7743 QLEWMQSEYGLGADDAVLLHTSAAFDLSVWEFWWAPRTGARLVLAPEGAHRDPQGLLDLL 7802 Query: 712 SRRGVT-VXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNH 770 + VT V LR + V GEALP + R A L N Sbjct: 7803 TYAAVTTVTLVPAQVAMLTEVAGERGLPAALRRLLVIGEALPTDTVRRTGESTQARLDNL 7862 Query: 771 YGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQL 830 YGPTEA V T V PIG P YVLD++LHPVP V+GELYLGG+QL Sbjct: 7863 YGPTEATVSVTRYRTGADEHGAVAPIGAPEAGTRVYVLDDRLHPVPTGVVGELYLGGAQL 7922 Query: 831 ARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIE 889 ARGY RP LTA+RF+ADPF PG RLYRTGDLVR G+L FV R D QVK+RG+RIE Sbjct: 7923 ARGYHRRPDLTAERFVADPFGAPGERLYRTGDLVRWTAEGQLVFVQRRDFQVKVRGYRIE 7982 Query: 890 LGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVP 949 L E+E + HPAV +V+A + V VD E++RA A +P YMVP Sbjct: 7983 LTEIEHALRAHPAVAEAVVLAHGAGGAEAMLVGYVTTRTPVDTEDLRAALAGTLPGYMVP 8042 Query: 950 GAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAE 1009 A + +P+T +GKLDR ALP P + R YR PET E +C+ FA+ G +RVG + Sbjct: 8043 AALVRLDALPLTANGKLDRAALPRP-DLRAREYRAPETELETAVCAAFAEALGVERVGLD 8101 Query: 1010 DSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 D+FF GG+SLLA RL ++ A + V +F APTPAG+ +L Sbjct: 8102 DNFFERGGNSLLATRLATRLAARLAEPVPVIWLFAAPTPAGIVDQL 8147 Score = 55.5 bits (132), Expect = 7e-05 Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 3/89 (3%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMTIA 1618 E + A+ ELL + + D+N+FALGG+S++A + A+ A ALG+ F+ T+A Sbjct: 646 EHAVAAVFAELLGVDRVGADDNFFALGGNSLLATRAIARVAAALGVTIDVRDFFDRPTVA 705 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 LAA A P + A P P E+ P+S Sbjct: 706 ALAALSGTAEARPPLTAQPRP--EHIPLS 732 Score = 49.3 bits (116), Expect = 0.005 Identities = 36/96 (37%), Positives = 55/96 (57%), Gaps = 9/96 (9%) Query: 1560 ERRLTAMLEELLEI-TGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTI 1617 E L ++ ELL + D+++F LGG+S++A++ A+AG ALG+ VFE T+ Sbjct: 3845 ETVLATLIAELLGGGVRVGADDDFFTLGGNSLLAMRLVARAGSALGVDLTVREVFEAPTV 3904 Query: 1618 AELAAAVDAANGEPVVEADPP----PAQEYTPMSAS 1649 A+LA V AA G P + PP P + P+SA+ Sbjct: 3905 AQLAERVRAAAGAP---SRPPLAARPRPQRIPLSAA 3937 Score = 48.1 bits (113), Expect = 0.010 Identities = 32/92 (34%), Positives = 49/92 (53%), Gaps = 2/92 (2%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMT 1616 ETER + A+ ++L I D+++FA GG+S+ A + A+ GA L P ++F+ T Sbjct: 4897 ETERLVAAVFADVLGRADIGADDDFFASGGNSLSATRAVARLGADLAADLPVRLLFDAPT 4956 Query: 1617 IAELAAAVDAANGEPVVEA-DPPPAQEYTPMS 1647 +A AA A P A P P E+ P+S Sbjct: 4957 VAGFAARAAAFAATPRKPALAPRPRPEHVPLS 4988 Score = 45.1 bits (105), Expect = 0.089 Identities = 30/83 (36%), Positives = 45/83 (54%), Gaps = 7/83 (8%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMTIA 1618 E + + +LL + +++FALGG+S+IA + +A+ A G+P P VF+ T+A Sbjct: 2778 ETLVAGIFADLLGHPAVGAGDDFFALGGNSLIATQLAARLTAARGVPVPVRAVFDAPTVA 2837 Query: 1619 ELAAAVDAANGEPVVEADP--PP 1639 ELA V G P A P PP Sbjct: 2838 ELARVV----GAPAESAAPDLPP 2856 Score = 43.1 bits (100), Expect = 0.34 Identities = 30/87 (34%), Positives = 45/87 (51%), Gaps = 8/87 (9%) Query: 1568 EELLEITGIDR---DENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTIAELAAA 1623 E + G+DR D+++F LGG+S+ A + A+ G LG P ++FE T+ LAAA Sbjct: 5964 EAFATVLGVDRPGVDDSFFDLGGNSLSATRVLARLGERLGRRVPVRLLFEEPTVRGLAAA 6023 Query: 1624 V----DAANGEPVVEADPPPAQEYTPM 1646 + DA P+V PP P+ Sbjct: 6024 LTAGADAEAVVPLVAGPRPPVLPLAPV 6050 Score = 40.4 bits (93), Expect = 2.2 Identities = 25/71 (35%), Positives = 42/71 (59%), Gaps = 3/71 (4%) Query: 1560 ERRLTAMLEELLEITG--IDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMT 1616 +R + A+ E+L + + D+++FA GG+S+ A + +A+ G AL + VFEH T Sbjct: 7006 QRAVAAVFAEVLGLPADRVGLDDDFFARGGNSLTATQLAARLGAALSVTVGVRTVFEHAT 7065 Query: 1617 IAELAAAVDAA 1627 +A LA A+ A Sbjct: 7066 VAALADALAGA 7076 >tr|Q0SKF6|Q0SKF6_RHOSR Tax_Id=101510 SubName: Full=Non-ribosomal peptide synthetase; EC=5.1.1.13; EC=6.1.1.13;[Rhodococcus sp.] Length = 10372 Score = 789 bits (2038), Expect = 0.0 Identities = 528/1481 (35%), Positives = 737/1481 (49%), Gaps = 81/1481 (5%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+RMWFL D N+ ++ RL G +D + L A+ DV RH LRT + DT Sbjct: 1098 LSVAQQRMWFLNQFDTASPAYNLPISLRLTGALDREALRAALGDVQERHEALRTVFP-DT 1156 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 P+Q+ V V + P + + + G FDLT + PLR + R Sbjct: 1157 PDGPHQLVVPVVSVLAETD-----PIDVDAKSLTAAVTALGGAGFDLTTDTPLRAGLFRE 1211 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVEV 212 D VL+LVVHH+ D S ++ AY LP+ E+ Sbjct: 1212 APDRHVLVLVVHHVAADGWSMTPLAADVMVAYAARVAGHAPTWAPLPVQYADYTLWQREL 1271 Query: 213 LQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAGLFSR 266 L + P S + +W L P + R R + A + R Sbjct: 1272 LGSEDDPDSVSARQIAHWQSALAGVPQLLELPA-DRPRPAEMSHRGGRVEFTITADVHGR 1330 Query: 267 VEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLL 325 + D A+ + FMV AA VL R +D ++ PV R A L G F NTL+L Sbjct: 1331 LVDLAQSTGTTLFMVTHAALVVLFHRLGAGTDIVIGTPVAGRGEEALDDLVGMFVNTLVL 1390 Query: 326 RITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMR 385 R T DTF ++ VR+ LA F+H V +R+V +P+R V L F Sbjct: 1391 RATAEPGDTFEEVLDRVRDADLAAFSHADVPFERLVEVLSPDRSAARHPLFQVMLSFQ-N 1449 Query: 386 KSAGGLALDGVVVRQLGLGAVAAHLPLSLTI------ALDPDDVSVEFEYQQQL-SSVLV 438 + + L G+ V + A L LT+ A P ++ F+Y L V Sbjct: 1450 TAPTSVELPGLEVAAAEIDVHVAKFDLQLTVTERFVGAGMPGGLAAGFDYATDLFDESTV 1509 Query: 439 DQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXX 498 M + L+ A + L +L A ERD +L + +PA M Sbjct: 1510 ASMAERFANLLRSVAASSATVVGDLSLLHAAERDRLLGTWNDTAHRVPA--MCLPELFDA 1567 Query: 499 XXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAML 558 V + L+YS+L RAN +AR+ I +G GPE +GL M S + +V M Sbjct: 1568 QVARTPDAVAVVFGDVTLSYSQLDCRANSVARYLIDRGVGPESRVGLAMRRSPDLLVGMY 1627 Query: 559 AVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-----------GRPELDVAERAAADN 607 A++KAG AY+P+DP +P +RI Y++ A+P V+ G+ +++ A Sbjct: 1628 AIVKAGGAYVPVDPDHPTDRIGYVLDSAQPVCVLTTSADRGALPAGQSFVEIDRIALDSY 1687 Query: 608 SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDR 667 S P++DSDRL PLRP + AYVIYTSGSTGRPKGV+V H I + +E+ +T D Sbjct: 1688 SGGPVTDSDRLAPLRPDNPAYVIYTSGSTGRPKGVSVPHRGIVNQLLWMQSEYALTERDV 1747 Query: 668 WLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXX 727 LQ ++ +FD SL F L GA +++ PD D Y+A +I GVTV Sbjct: 1748 LLQKTATTFDVSLWGYFWPLHTGATMVLATPDGHRDPEYLARVIDEHGVTVTDFVPSMLD 1807 Query: 728 XXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTG 787 LRHV V GEALP E RF DA L N YGPTEA V T+ T Sbjct: 1808 AFVASVPITSCSTLRHVFVIGEALPPETVTRFRALSDAGLHNLYGPTEAAVSVTYWD-TA 1866 Query: 788 SHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIA 847 + A VPIGVP N YVLD +LHPVP V GELYL G QLARGYLGR LT+ RF+A Sbjct: 1867 TTVAGTVPIGVPEWNTQVYVLDSRLHPVPPGVAGELYLAGEQLARGYLGRVDLTSDRFVA 1926 Query: 848 DPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCL 907 +PF PG+R+YRTGDLVR G LE++GR D QVK RG RIELGE+E V+ P+V Sbjct: 1927 NPFTPGLRMYRTGDLVRWTSAGALEYIGRTDFQVKFRGQRIELGEIEFVLRAQPSVTSAA 1986 Query: 908 V-VAEETEAGPMLAAYLVPAAA-QVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGK 965 V V + G L AY+VP +D +R AA++P YM+P A V+ E P+ SGK Sbjct: 1987 VLVHSDPGTGDRLVAYVVPEPGHDLDTTRLRECAAASLPAYMIPAALMVVDEFPLNTSGK 2046 Query: 966 LDRRALPAPT-PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAAR 1024 LDR+ALPAP + Y P T+ E + IFA++ G R+G D+FF +GG+SL+A R Sbjct: 2047 LDRQALPAPEFGGSGTEYVAPRTSVEANLAEIFAEVLGLDRIGLRDNFFDVGGNSLVATR 2106 Query: 1025 LVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 + ++IRAE G L +R +FDAPT LA R+ + R Sbjct: 2107 VTSRIRAELGAPLALRDLFDAPTVGALAERIEGTVQT-------------------TPRA 2147 Query: 1085 GFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXR 1144 V + R R+PLS +Q WF + + A +NMP ALR G R Sbjct: 2148 PLVAATRAGRIPLSPAQRRMWFVNQFDTASAAYNMPFALRLSGILDCDGLRSAIRDVLER 2207 Query: 1145 HEALRTNFDEHEGVPYQIVHPSRTV--QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQ 1202 HE+LRT + + P+Q++ + V L V+ I + E +L F S L+ Sbjct: 2208 HESLRTLYPDSTDGPHQVIVGADEVPLDLDVQPITEAELPTRLVELATEGFDVTSAVPLR 2267 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYA 1262 LL L D +VL ++VHHI +D +S+ + D+++AY AR AP W L +Q+ADY+ Sbjct: 2268 TALLRLSVDEYVLAVVVHHISADGSSMAPLARDILLAYTARTAGRAPSWPPLDVQYADYS 2327 Query: 1263 VWQR-----NTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPA 1317 WQ T + ++++W AL G+PD + + DR RP + G V FSV A Sbjct: 2328 YWQAEFLGDETDGRSQATEQIEFWSAALDGIPDLLELPADRPRPAMPTNSGATVPFSVDA 2387 Query: 1318 ARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFA 1377 A A+ LA R+ AT FM++ AAL+V+L +L D+ +G+PVA R EP+ LVG+F Sbjct: 2388 ATAKAVADLAARSAATPFMVWHAALSVLLSRLSNAVDVTVGTPVAGRAEPSLQDLVGMFV 2447 Query: 1378 NVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNML 1437 N + LR +SGD + +L R+ L A AH +LP ERLVE L P R+ +R+PLFQ L Sbjct: 2448 NTLTLRARVSGDLSFADLLAQVREFDLAAFAHADLPFERLVEVLEPARSTARHPLFQVGL 2507 Query: 1438 NFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMS 1478 ++ + ++ +L G TV + +N E+A L + ++ Sbjct: 2508 SYENFEPGVL--ELPG---LTVSAVEMNPEIAKFDLNVTLT 2543 Score = 774 bits (1998), Expect = 0.0 Identities = 525/1470 (35%), Positives = 737/1470 (50%), Gaps = 107/1470 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 E LS Q+RMWF+ D N+ VA RL+G VD + A+ D+V RH LRT Y Sbjct: 7965 EHIPLSLAQQRMWFINQFDTASPAYNLPVALRLSGEVDLRAMQIAIADLVGRHEALRTVY 8024 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G P+QV V G DLT P A H + FD+T ++PLR Sbjct: 8025 PDSVDG-PHQVI---VPAGDAVPDLT--PVAAHPDDVLDRVLALVTTGFDVTADVPLRAR 8078 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFL 208 + R AD+ VL++V HHI D S ++ AY LP+ Sbjct: 8079 MYRVGADDYVLVMVAHHISGDGWSLAPLARDVMLAYTARAEGHVPRWTPLPVQYADYSLW 8138 Query: 209 SVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPA---- 261 E+L + P + A + YW TL P R + RP PA Sbjct: 8139 QRELLGDETDPESVAAAQIAYWTRTLEGL-------------PDRPSLPTDRPRPAVASH 8185 Query: 262 -----------GLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSG 310 G + AR + S FMV+ A VL+ R + SD V P+ R Sbjct: 8186 LGAHVPFTIDAGTHRALLALARGRNTSLFMVMHTALAVLLARLSNESDIAVGAPIAGRGE 8245 Query: 311 AAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM 369 + L G F NTL+LR +F + +VR L FAH + +R+V NP R Sbjct: 8246 ESLDELVGMFVNTLVLRTRVALASSFADSLADVRSADLNAFAHSDIPFERLVDVLNPARS 8305 Query: 370 GRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDDV 423 V F + L L G+ V L + ++ L LT++ PD + Sbjct: 8306 RAHHPLFQVAFSFQ-NLATTTLELPGLHVEGLDVPNTISNFDLHLTLSEKHDADGSPDVI 8364 Query: 424 SVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGEL 482 +F Y L V + +++ + +P+ + ++D+L ER S++A + Sbjct: 8365 EAQFTYATDLFDESTVRAFAERFTRVLASVVEDPDVAVGAIDLLDGPERQSIVADFNDTG 8424 Query: 483 VEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDI 542 V++P TT+ + + ELTY+E RR + LA I +G GPE + Sbjct: 8425 VDLPPTTLAELFSAQAARTPEKAAVFF--EGTELTYAEFDRRVDVLAHRLIDRGVGPESV 8482 Query: 543 IGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRP------- 595 +GL M SIE +V M AVL+AG AYLPID +P +R+ Y++ ARP ++ Sbjct: 8483 VGLAMNRSIELLVGMYAVLRAGGAYLPIDLTHPADRLAYVLATARPVCILTTSSDGFAAE 8542 Query: 596 -----ELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIA 650 E+D + + P++D+ RL PLRP + AY+I+TSGSTGRPKGVAV+H AIA Sbjct: 8543 SVPVIEIDTLDHTGSPRE--PVTDARRLAPLRPENTAYLIFTSGSTGRPKGVAVTHAAIA 8600 Query: 651 EHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADL 710 ++ E+++ D +Q + V+FD S+ ++F L GA+L++ +PD D +Y+ADL Sbjct: 8601 NQLRWKQHEYSLDTTDAVVQKTPVTFDLSVWELFWPLTTGARLVIARPDGHRDPAYLADL 8660 Query: 711 ISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDA-ELRN 769 + ++ VT + LR V GEALP + A RF F L N Sbjct: 8661 MRQQRVTTAHFVPSLLEAFLATPDAGEQPALRRVLCIGEALPVDTAARFRRRFGTVALHN 8720 Query: 770 HYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQ 829 YGPTEA V T T VPIG P N +VLD +L+PVP V GELYL G Q Sbjct: 8721 LYGPTEAAVSVTAWTHTADD-VDTVPIGGPEWNTQVFVLDARLNPVPVGVAGELYLAGEQ 8779 Query: 830 LARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVR---RNHCGELEFVGRADEQVKIRG 885 LARGY+ R LTA+RF+A+PF G RLYRTGD+VR R+ G LE++ R+D QVK+RG Sbjct: 8780 LARGYVARADLTAERFVANPFGASGSRLYRTGDVVRWHVRDSRGVLEYLERSDFQVKVRG 8839 Query: 886 FRIELGEVESVITTHPAVRHCLVVAEE-TEAGPMLAAYLVPA-AAQVDLEEIRAHTAAAV 943 FRIELGE+ES + + V +VVA + G L Y+VP A VD + A AAV Sbjct: 8840 FRIELGEIESALVSSAGVGQAVVVAHQHPHTGTTLIGYVVPEDGATVDFAAVLAEVGAAV 8899 Query: 944 PEYMVPGAFAVIPEIPMTVSGKLDRRALPAPT-PIATRRYREPETATERWICSIFAQLFG 1002 P YMVP A V+ ++P+T +GKLDRRALPAP AT YR P T TE + ++FA + G Sbjct: 8900 PSYMVPAALVVLAQLPLTSNGKLDRRALPAPDFASATDEYRAPATPTEEAVAAVFADVLG 8959 Query: 1003 RQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRND 1062 +VG +FF LGG+SL+A R+VA++ G + +RT+F+APT A LAA L Sbjct: 8960 VDQVGTAANFFDLGGNSLVATRVVARLSERLGCRVEIRTLFEAPTVAALAALL------- 9012 Query: 1063 FELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLA 1122 D++ A ARP + RP+R+PLS +Q WF R + N+P A Sbjct: 9013 -----DSIDAT------APARPALTPAVRPERIPLSSAQHRMWFLNRFDPNSAVHNIPAA 9061 Query: 1123 LRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV--QLAVRAIDQDE 1180 +R G RHE+LRT + + P+Q++ P V +++V A D+ Sbjct: 9062 VRLSGALDVDALQHAVADVVRRHESLRTVYPDSADGPHQVILPIDRVGGEMSVVATDEAA 9121 Query: 1181 FDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAY 1240 + L F + ++ + + HVL L+VHHI D S+ + D++ AY Sbjct: 9122 LPALIAGLVTTGFDVTTEVPVRVRIFRMSATEHVLALVVHHISGDGWSMAPMVRDVMTAY 9181 Query: 1241 RARLQHNAPQWDILPIQFADYAVWQR-----NTFESNWGQTELDYWRDALAGLPDEISVA 1295 AR P W LP+Q+ADYA+WQR T + +L +W LAG PD++ + Sbjct: 9182 AARSADTTPDWAPLPVQYADYALWQRALLGDETDPESVSARQLAFWTHTLAGAPDQLDLP 9241 Query: 1296 TDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDI 1355 TDR RP V RG V F+VPA L A A+ FML AALAV+L +L G DI Sbjct: 9242 TDRPRPAVASYRGGTVDFTVPADLHGTLLGAARDANASLFMLVHAALAVLLSRLSGTGDI 9301 Query: 1356 ALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIE 1415 A+G+PVA R E L+G+F N +VLR + G T ++ R+T L A +H ++P E Sbjct: 9302 AIGTPVAGRGERELDDLIGMFVNTLVLRQQVDGGRTFAELVADVRETDLAAFSHADVPFE 9361 Query: 1416 RLVEALNPPRALSRNPLFQNMLNFRGEDWA 1445 RLVE +NP R+ R+PLFQ ML F+ D A Sbjct: 9362 RLVEVVNPSRSTGRHPLFQVMLTFQNLDQA 9391 Score = 706 bits (1823), Expect = 0.0 Identities = 498/1470 (33%), Positives = 720/1470 (48%), Gaps = 95/1470 (6%) Query: 26 AAEQSSDQPGICPG---ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLH 82 A + +S P + P +R LS Q+RMWFL + N+ A RL G +D L Sbjct: 6890 AGDGASAGPALAPQPRPDRIPLSLAQQRMWFLNQFETSSPAYNLPAAVRLTGPLDTAALA 6949 Query: 83 TAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLT--RLPEAGHERQIESLA 140 A++D++ RH LRT + D+ G P+QV +E G D R+ E+G +E Sbjct: 6950 AAIDDLITRHESLRTVFP-DSRGGPHQVI---LEPGQFTPDTAPVRVSESGLRADLEQFL 7005 Query: 141 ADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND--- 197 F D++ +PLR+ V E VL VVHHI D S E ++ AY+ Sbjct: 7006 LTGF----DVSQAVPLRVKVYSLGDTEHVLAFVVHHIAADGVSMEPLIRDVMIAYSSRAA 7061 Query: 198 --------LPINDPAAQFLSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSG- 245 LP+ EVL + P + A + YW TL G G Sbjct: 7062 GHAPSWAPLPVQYADYALWQREVLGVESDPGSLAAAQLEYWTRTLAGVPDQLYLPGDRGR 7121 Query: 246 -ANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVP 304 A P R L A + + AR AS FMV AA VL+ R + +SD V Sbjct: 7122 PAVPSHRGAATRFTLDADTHRALAELARAHGASIFMVAHAALSVLLGRLSTSSDITVGTA 7181 Query: 305 VTERSGAAAG-ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVRE 363 + R +G F NTL+LR T +F S + + R+ L FAH + +R+V Sbjct: 7182 IAGRGRVELDDIIGMFVNTLVLRTTLDPGASFVSLLEQARDVDLEAFAHADLPFERLVEV 7241 Query: 364 ANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDV 423 +P R V LG SA L LDG+ + L L A A L T+ DD Sbjct: 7242 LSPVRSTSHHPLFQVALGVQA-VSADRLELDGLSLEPLTLDASTAKFDLHFTLTERLDDA 7300 Query: 424 S------VEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA 476 S E Y + + + ++ + +A+P+RP+ + +LG E + L Sbjct: 7301 SEAAGIDAELVYATDIFDESTAAEYAIRLRRIFEAVVADPQRPIGDIPVLG-DEEYAALT 7359 Query: 477 QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQG 536 G + M+ E+ LTY +L R+N+LAR + +G Sbjct: 7360 PVRG--ADARPVQMLPEILADAVAAAPDGPAVVFEGES-LTYRDLDERSNQLARLLVDRG 7416 Query: 537 FGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQ---TVIG 593 GPE + L + S+E +VA+ AV K GAA++P+DP YP +R+ +++ D+ TV Sbjct: 7417 VGPETRVALALPRSLESVVAVWAVAKTGAAFVPVDPGYPADRVLHMVQDSGAMVGITVSA 7476 Query: 594 RPE----------LDVAERAA--ADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKG 641 + + LD A S LPL++ DR+RP+ +AYVIYTSGSTGRPKG Sbjct: 7477 KQDVLPDSIRWMLLDDPALAVRCTHESRLPLTNRDRMRPILSDQVAYVIYTSGSTGRPKG 7536 Query: 642 VAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAF 701 VAV+H + V +T+ R L F+S SFDAS+ ++ + L GA +++ P + Sbjct: 7537 VAVTHRGLMNLVTDERELLGVTSGSRTLHFASPSFDASVFEMLMALGAGATMVIAPPTIY 7596 Query: 702 GDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAG 761 G S +A+L++ VT L V V G+ P E+ R+A Sbjct: 7597 GG-SELAELLAAEHVTHAFSTPAALASVDHHGLD----DLAVVVVAGDVCPPELVARWAP 7651 Query: 762 YFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIG 821 + N YGP+EA + S+ + V IG P+R V A VLD +L PVP V G Sbjct: 7652 --GRRMVNAYGPSEATIMSS--ITEPLRAGEPVTIGGPSRGVRALVLDGRLRPVPVGVPG 7707 Query: 822 ELYLGGSQLARGYLGRPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQ 880 ELY+GG LARGYLGRP LTA+RF+ADP+ PG +YRTGDLVR L+FVGR D Q Sbjct: 7708 ELYVGGPSLARGYLGRPGLTAERFVADPYGEPGDLMYRTGDLVRWRENRVLDFVGRTDHQ 7767 Query: 881 VKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPAAAQ-VDLEEIRAH 938 VKIRGFRIELGE+++ +T HP + + + E G L AY++P + VD E+ Sbjct: 7768 VKIRGFRIELGEIDAALTAHPQIEYATTIGYEHPNGETSLVAYVLPFTGEDVDRVEVANF 7827 Query: 939 TAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPI-ATRRYREPETATERWICSIF 997 +P YMVP + ++ +P+T +GKLDR ALP P + A + P E + IF Sbjct: 7828 VGRTLPAYMVPASVTLLDALPLTPAGKLDRAALPEPIFVAAATTFEAPRNPMEVIVAGIF 7887 Query: 998 AQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVE 1057 A + +G DSFF LGG+SLLA ++V++I A V + VR +F++PT A LAAR+ E Sbjct: 7888 ADILALPEIGIHDSFFDLGGNSLLATQVVSRINAALDVHVGVREVFESPTVAALAARITE 7947 Query: 1058 RFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEF 1117 + RP RP+ +PLS +Q WF + + A + Sbjct: 7948 TTTHGVR------------------RPALTAKPRPEHIPLSLAQQRMWFINQFDTASPAY 7989 Query: 1118 NMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPS--RTVQLAVRA 1175 N+P+ALR G RHEALRT + + P+Q++ P+ L A Sbjct: 7990 NLPVALRLSGEVDLRAMQIAIADLVGRHEALRTVYPDSVDGPHQVIVPAGDAVPDLTPVA 8049 Query: 1176 IDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDD 1235 D+ D L F + L+A + +G D +VL+++ HHI D SL + D Sbjct: 8050 AHPDDVLDRVLALVTTGFDVTADVPLRARMYRVGADDYVLVMVAHHISGDGWSLAPLARD 8109 Query: 1236 LIVAYRARLQHNAPQWDILPIQFADYAVWQR-----NTFESNWGQTELDYWRDALAGLPD 1290 +++AY AR + + P+W LP+Q+ADY++WQR T + ++ YW L GLPD Sbjct: 8110 VMLAYTARAEGHVPRWTPLPVQYADYSLWQRELLGDETDPESVAAAQIAYWTRTLEGLPD 8169 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 S+ TDR RP V G V F++ A AL LA + FM+ ALAV+L +L Sbjct: 8170 RPSLPTDRPRPAVASHLGAHVPFTIDAGTHRALLALARGRNTSLFMVMHTALAVLLARLS 8229 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 +DIA+G+P+A R E + +LVG+F N +VLRT ++ + L R L+A AH Sbjct: 8230 NESDIAVGAPIAGRGEESLDELVGMFVNTLVLRTRVALASSFADSLADVRSADLNAFAHS 8289 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 ++P ERLV+ LNP R+ + +PLFQ +F+ Sbjct: 8290 DIPFERLVDVLNPARSRAHHPLFQVAFSFQ 8319 Score = 703 bits (1814), Expect = 0.0 Identities = 488/1408 (34%), Positives = 701/1408 (49%), Gaps = 75/1408 (5%) Query: 72 LAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAG 131 L G V DR+ A ++ R++ LR + D + Q+ VEV DL+ Sbjct: 3751 LLGDVSADRMRAAAAALLDRYSNLRVVFVQDGDVTA-QIPLRGVEVPLTVVDLSGRESDS 3809 Query: 132 HERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGEL 191 ER++ESL A+ PFDL+ LR+ ++RT AD L + HHI D S + +L Sbjct: 3810 GERELESLVAENRTAPFDLSEAPLLRLLLVRTGADRHELAMTNHHILLDGWSIPLIVQDL 3869 Query: 192 SAAY------NDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGV-S 244 Y + LP P ++L ++ +A A WA L + Sbjct: 3870 LVLYATAGDQSALPAVRPYREYLDWLTRRDPSASRAA----WAHALEGFDEPTLLAPAHT 3925 Query: 245 GANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVP 304 G + + A + + FAR+ +P V+ A+ +L+RR TG D + Sbjct: 3926 GGSATADPEEVPVHFSAADTAELLAFARQHGVTPNTVIQTAWALLLRRLTGRDDVVFGAT 3985 Query: 305 VTERSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVV 361 V+ R G +G F NT+ +R+ + ++ + V+ H +G+ + Sbjct: 3986 VSGRPPHIPGIESMVGLFINTVPVRVRIDADESVAELLVRVQGQQADLLDHHYLGLTEIQ 4045 Query: 362 REANPERMGRDGMDLLVRLGFNMRKSA-------GGLALDGVVVRQLGLGAVAAHLPLSL 414 EA +G L V + M ++A G+ +D V V + H PLSL Sbjct: 4046 AEAG---VGALFDTLTVFESYPMDQAALQAQTDIAGMRVDSVQVHSV------THYPLSL 4096 Query: 415 TIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKAL-AEPERPLSSLDILGAGERDS 473 +D D + + Y +++ L V +AL AEP ++ + GE Sbjct: 4097 MAQVD-DTLRLGVAYLPDTFERDEARLIAARLDSVIRALIAEPSAAVAQVTGFIPGEYAR 4155 Query: 474 VLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFI 533 V+ + +P +T++ D LTY+ L RAN+LAR I Sbjct: 4156 VMHDWNATGHHVPESTLLTLFEAQAARTPDAVAVDFDGDV--LTYAALDARANQLARHLI 4213 Query: 534 GQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI- 592 G PE + + M S+E +V + AVLKAG AY+P+DP +P ER Y++ A+P V+ Sbjct: 4214 ALGVAPETRVAVVMRRSLELVVGIYAVLKAGGAYVPVDPDHPAERTSYVLASAQPVCVLT 4273 Query: 593 ---GRPEL-DVAERAAADNSDL------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGV 642 RP+L + +A D DL PL+D++R+ PLRP H AYVIYTSGSTG+PKGV Sbjct: 4274 TSADRPDLPNRIPVSALDTLDLSGVSAVPLTDAERIEPLRPAHPAYVIYTSGSTGKPKGV 4333 Query: 643 AVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFG 702 AV H AI + +E+ +T D WLQ ++ +FD SL F L +GA +++ PD Sbjct: 4334 AVPHAAIVNQLLWMQSEYALTDRDVWLQKTATTFDVSLWGYFWPLQVGATMVLATPDGHR 4393 Query: 703 DISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGY 762 + +Y+ +I R VTV R LR V V GEALP RF Sbjct: 4394 EPAYLTRVIDERAVTVTDFVPSMLDVFVAAAPEGTCRSLRLVFVIGEALPPATVLRFREL 4453 Query: 763 FDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGE 822 A L N YGPTEA V T+ TG VPIGVP N AYVLD +LHPVP V GE Sbjct: 4454 SAAGLHNLYGPTEAAVSVTYWK-TGDADTTNVPIGVPEWNTQAYVLDSRLHPVPVGVPGE 4512 Query: 823 LYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQV 881 LYLGG+QLARGYLGR LT+ RF+A+PF G R+YRTGDLVR G L ++GR D QV Sbjct: 4513 LYLGGAQLARGYLGRVDLTSDRFVANPFGRTGERMYRTGDLVRWTSSGALVYIGRTDFQV 4572 Query: 882 KIRGFRIELGEVESVITTHPAVRHCLV-VAEETEAGPMLAAYLVPAAAQVDLEEIRAHTA 940 K RG RIELGE+E+V+ +HPAV +V V +T G L AY+V ++D+ E+R + Sbjct: 4573 KFRGQRIELGEIETVLRSHPAVTGAVVSVYSDTTVGDHLVAYVVGTPGELDVAELRRQAS 4632 Query: 941 AAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPT-PIATRRYREPETATERWICSIFAQ 999 ++P YMVP A V+ E P+ SGKLDR+ LPAP ++ Y P ER + ++FA Sbjct: 4633 ESLPSYMVPSAITVLDEFPLNTSGKLDRKELPAPEFHGSSTEYIAPRNEAERTVAAVFAD 4692 Query: 1000 LFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERF 1059 + G RVGA D+FF LGG+SL R+ A++ G L+VR +F APT A LA RL E Sbjct: 4693 VLGSSRVGAHDNFFDLGGNSLSVTRVAARLGELSGTGLSVRDVFTAPTVAELARRLAE-- 4750 Query: 1060 RNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNM 1119 P ARP RP R+PLS +Q WF + + + +N+ Sbjct: 4751 ----------------PTAAGGARPVLSGMQRPARIPLSPAQQRMWFINQFDPSSPAYNL 4794 Query: 1120 PLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAID-- 1177 P A+R G RHE+LRT F + + P Q+V + + + + +D Sbjct: 4795 PFAVRMSGALDVAALSQALDDVVGRHESLRTVFPDTDDGPAQVVVSAADLSMPLEVVDVP 4854 Query: 1178 QDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLI 1237 + E D H F ++A L GP HVL + +HHI +D S + D++ Sbjct: 4855 EGELDSRMIAFSSHGFDVSEDLPVRATLFRTGPGEHVLAITLHHIAADGWSFGPLGADVM 4914 Query: 1238 VAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEI 1292 VAY AR + +P+W L +Q+ADY+VW R S + + +L+YW L GLPDE+ Sbjct: 4915 VAYAARAESRSPEWIPLAVQYADYSVWHRAVLGSEDEPESLARRQLEYWTRTLDGLPDEL 4974 Query: 1293 SVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGG 1352 + DR R G V F++ + + +LA +GAT FM+ AA A++L +L Sbjct: 4975 KLPFDRPRRTEQSYVGGSVGFTITPEIHSGIERLAREHGATVFMVAHAAFALLLARLSAS 5034 Query: 1353 TDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQEL 1412 DIA+G+P+A R E A LVG+F N +VLRT + T +L RD + A H +L Sbjct: 5035 DDIAVGAPIAGRGERALDNLVGMFVNTLVLRTRIESTETFAELLTRVRDGDIGAFGHADL 5094 Query: 1413 PIERLVEALNPPRALSRNPLFQNMLNFR 1440 P ERLV+ L+P R + +P+ Q L+ + Sbjct: 5095 PFERLVDVLDPVRTSAHHPVIQTALSMQ 5122 Score = 686 bits (1771), Expect = 0.0 Identities = 490/1469 (33%), Positives = 732/1469 (49%), Gaps = 123/1469 (8%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS Q+RMWF+ DP N+ A R++G +D L A++DVV RH LRT + Sbjct: 4769 RIPLSPAQQRMWFINQFDPSSPAYNLPFAVRMSGALDVAALSQALDDVVGRHESLRTVFP 4828 Query: 101 VDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITV 160 DT+ P QV ++ E + +PE E +A G FD++ +LP+R T+ Sbjct: 4829 -DTDDGPAQVVVSAADLSMPLE-VVDVPEG--ELDSRMIAFSSHG--FDVSEDLPVRATL 4882 Query: 161 IRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND---------LPINDPAAQFLSVE 211 RT E VL + +HHI D S+ ++ AY +P+ A Q+ Sbjct: 4883 FRTGPGEHVLAITLHHIAADGWSFGPLGADVMVAYAARAESRSPEWIPL---AVQYADYS 4939 Query: 212 VLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAG- 262 V + S + + YW TL P R +R + G Sbjct: 4940 VWHRAVLGSEDEPESLARRQLEYWTRTLDGLPDELKL-------PFDRPRRTEQSYVGGS 4992 Query: 263 --------LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 + S +E AR+ A+ FMV AA+ +L+ R + + D V P+ R A Sbjct: 4993 VGFTITPEIHSGIERLAREHGATVFMVAHAAFALLLARLSASDDIAVGAPIAGRGERALD 5052 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 L G F NTL+LR S +TF + VR+ + F H + +R+V +P R Sbjct: 5053 NLVGMFVNTLVLRTRIESTETFAELLTRVRDGDIGAFGHADLPFERLVDVLDPVRTSAHH 5112 Query: 374 MDLLVRLGFNMRKSA-GGLALDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVSVE 426 +++ +M+ +A + L G+ VR + A A L LT+ D P + E Sbjct: 5113 P--VIQTALSMQPTAIDDIELPGLRVRVEDIDARVAKFDLQLTLGEDIDPAGVPSGIRAE 5170 Query: 427 FEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM 485 F Y L V V + +++++ +A+P + +++L ER + LA G Sbjct: 5171 FTYAADLFDDVTVRRYAGQLVRILETVIADPTTVVGDVNLLDDAER-ARLAPVRGP-ASR 5228 Query: 486 PATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGL 545 P+ + + V + +TY EL RR+N AR I G GPE + + Sbjct: 5229 PSRLLPEVLAESAADPSATAL---VFGDRSMTYGELDRRSNLWARELIEAGAGPETFVAV 5285 Query: 546 RMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITD---ARPQTVI----GRPE-- 596 +A SIE ++A+ AV K GAA++P+DP YP ERI +++ D A T I G P+ Sbjct: 5286 ALARSIESVLAVWAVAKTGAAFVPVDPNYPAERIAHMLGDSGSALGLTTIEFRAGLPDST 5345 Query: 597 ----LDVAERAA--ADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIA 650 +D + A +S ++ +DRL + LAY+IYTSGSTG PKGVAV+H +A Sbjct: 5346 QWLVMDDPDHTALVTSHSSAAVTAADRLGRMHADQLAYLIYTSGSTGLPKGVAVTHSGLA 5405 Query: 651 EHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADL 710 + E+ +TA+ R L F+S SFDAS+ + + GA ++V +G +A+L Sbjct: 5406 NLLTELADEYELTADARTLHFASPSFDASVFEYLMAFCRGATMVVVPHSVYGGTE-LAEL 5464 Query: 711 ISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNH 770 + +GVT +L + VGGEA ++A+R+ L N Sbjct: 5465 LGAQGVTHAFFTPAALASVDHTGLD----ELAVIVVGGEAWGADLAERWVP--GRALFNG 5518 Query: 771 YGPTEAVVCSTHMVVTGSH----GARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLG 826 YGPTE+ M+VT S G R+ IG P R V A+VLD +LHPV V GELY+ Sbjct: 5519 YGPTES-----SMMVTQSGPLMLGERMT-IGAPVRGVEAFVLDARLHPVSPGVPGELYIS 5572 Query: 827 GSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVR----RNHCGELEFVGRADEQV 881 G LARGY R LTA+RF+A+P PG R+YRTGDLVR R +E+VGR+D QV Sbjct: 5573 GPALARGYHQRLGLTAERFVANPHGAPGRRMYRTGDLVRWVESRTGTYVIEYVGRSDFQV 5632 Query: 882 KIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAA--QVDLEEIRAHT 939 KIRGFR+ELGE++SV H AV +A +TE+G V AA+ VD++++ A Sbjct: 5633 KIRGFRVELGEIDSVFRAHSAVGFAATIAHDTESGVTALVTYVCAASGNDVDVDDLTAFV 5692 Query: 940 AAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQ 999 +P +MVPG+ V+ IP+T +GKLDRRALP P ++ R+ P+TA E + + FA Sbjct: 5693 GGVLPAHMVPGSIMVLDSIPLTPAGKLDRRALPEPVFVSHTRFTAPDTADEIAVAAAFAD 5752 Query: 1000 LFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERF 1059 + G R+G +D+FF LGG+SL A ++V+++ + FG ++VRT+FD PT L + + Sbjct: 5753 VLGESRIGVDDNFFALGGNSLSATQVVSRVGSAFGTRVSVRTLFDNPTVRQLVSAV---- 5808 Query: 1060 RNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNM 1119 A P D RP + P R+PLS +Q WF + + + +N+ Sbjct: 5809 ------------ATSGP-DASSGRPALTRREHPGRIPLSLAQQRIWFLNQYDPSSSAYNI 5855 Query: 1120 PLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQD 1179 PLALR G RHE+LRT + +Q + P+ + + I + Sbjct: 5856 PLALRMSGRIDVPALRAALGDVLERHESLRTVYPGSADGAHQEILPAAAAEFDLTPI-RT 5914 Query: 1180 EFDDVSTQLRRHV---FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDL 1236 D + ++ + F + +L HVLLL+ HHI +D S + D+ Sbjct: 5915 APDQLMLRIAEYAVAGFDVTREIPFRIHLFRENRSEHVLLLVAHHIAADGWSFGPLAADV 5974 Query: 1237 IVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDE 1291 + AY +R++ AP W+ LP+Q+ADY+VWQR + + T+++ WR AL G P+ Sbjct: 5975 MAAYASRVEGLAPSWEPLPVQYADYSVWQRELLGAEDDPDSLSATQIERWRAALDGAPEA 6034 Query: 1292 ISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGG 1351 + + TD RP V RGE V F + A L + A++ G T FM+ AA A +LH+L G Sbjct: 6035 LDLPTDHPRPAVASHRGERVDFEIDADTHRGLVERAQKGGTTLFMVVHAAFATLLHRLSG 6094 Query: 1352 GTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQE 1411 TDI +G+PVA R + LVG+F N + LRT + ++ ++L RD L A E Sbjct: 6095 STDIVIGTPVAGRGDEGLDPLVGMFVNTLALRTRIDPGESIDALLEQVRDVDLTAFQDTE 6154 Query: 1412 LPIERLVEALNPPRALSRNPLFQNMLNFR 1440 +P +RLVE L P R+ R+PLFQ M F+ Sbjct: 6155 VPFDRLVEILRPTRSSDRHPLFQVMFAFQ 6183 Score = 671 bits (1732), Expect = 0.0 Identities = 491/1483 (33%), Positives = 696/1483 (46%), Gaps = 111/1483 (7%) Query: 21 AESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDR 80 A SG A + PG P LS Q+R+WFL DP NI +A R++G +D Sbjct: 5815 ASSGRPALTRREHPGRIP-----LSLAQQRIWFLNQYDPSSSAYNIPLALRMSGRIDVPA 5869 Query: 81 LHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLA 140 L A+ DV+ RH LRT Y +G ++ + DLT + A + + Sbjct: 5870 LRAALGDVLERHESLRTVYPGSADGAHQEI----LPAAAAEFDLTPIRTAPDQLMLR--I 5923 Query: 141 ADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY----- 195 A+ FD+T E+P RI + R E VLLLV HHI D S+ ++ AAY Sbjct: 5924 AEYAVAGFDVTREIPFRIHLFRENRSEHVLLLVAHHIAADGWSFGPLAADVMAAYASRVE 5983 Query: 196 ------NDLPINDPAAQFLSVEVLQNSAAP---SVADVGYWAETL--RXXXXXXXXXGVS 244 LP+ E+L P S + W L Sbjct: 5984 GLAPSWEPLPVQYADYSVWQRELLGAEDDPDSLSATQIERWRAALDGAPEALDLPTDHPR 6043 Query: 245 GANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVP 304 A R +R + A + + A+K + FMV+ AA+ L+ R +G++D ++ P Sbjct: 6044 PAVASHRGERVDFEIDADTHRGLVERAQKGGTTLFMVVHAAFATLLHRLSGSTDIVIGTP 6103 Query: 305 VTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVRE 363 V R L G F NTL LR ++ + + +VR+ L F V DR+V Sbjct: 6104 VAGRGDEGLDPLVGMFVNTLALRTRIDPGESIDALLEQVRDVDLTAFQDTEVPFDRLVEI 6163 Query: 364 ANPERMGRDGMDLLVRLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD 422 P R V F N+R + L +VV + A L L +A DD Sbjct: 6164 LRPTRSSDRHPLFQVMFAFQNLRPVT--MELPQLVVEAVDFDPHIAKFDLDLALAEIVDD 6221 Query: 423 ------VSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVL 475 +S F + +L V +L++++ + + + + ILGA E+ S+ Sbjct: 6222 AGHHHGISGAFTFASELFERATVAGFADRFLRILEAVASADDIAVGDIAILGAAEQGSLA 6281 Query: 476 AQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQ 535 G L+ V D + Y EL RR+ +LAR IG Sbjct: 6282 PVWGGPLL----ANATLPELLVATAERYPDSTAVVFDGVSIDYRELDRRSTQLARALIGM 6337 Query: 536 GFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRP 595 G GPE + L + S+E ++ + A K GAAY+PIDPA+P +RI +++ D+ V+G Sbjct: 6338 GVGPETYVALALPRSVESVLCVWAAAKTGAAYVPIDPAHPADRIAHILRDSG--VVVGVT 6395 Query: 596 ELDVAE-----------------RAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGR 638 + AE R + S P+ D+DR L H AY+IYTSGSTG Sbjct: 6396 CAEFAEHLPGVTDWLVLDDPAVLRELSSASTAPVGDADRTSALHVDHPAYLIYTSGSTGL 6455 Query: 639 PKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKP 698 PKGV VSH +A + T E R +S +FD S+ ++ + GA L+V P Sbjct: 6456 PKGVVVSHRGLANLAGSYTTAVRATEESRVAHLASPTFDLSVLELLLAHTSGAALVVCPP 6515 Query: 699 DAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADR 758 +G + L S R + LR + VGG+A P E R Sbjct: 6516 GVYGGVELHEVLQSERVTHMTITNAALASVEPEGLD-----DLRSIVVGGDACPPETVAR 6570 Query: 759 FAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQ 818 +A EL N YGPTE V +T V G R + IG P V A VLD +L PVP Sbjct: 6571 WADRL--ELVNGYGPTEVTVGATFSSVLGQ--GRDITIGGPLPGVAAVVLDSRLRPVPVG 6626 Query: 819 VIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRN--HCG------ 869 V+GELYL G LARGY R LTA RF+A PF G R+YRTGD+VR H G Sbjct: 6627 VVGELYLLGPALARGYHERAALTAHRFVASPFEAAGARMYRTGDIVRWRAVHSGVTGSMT 6686 Query: 870 -------ELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAY 922 +E++GR+D QVK+RG RIELGE+++ + HP V + E+ A LA++ Sbjct: 6687 DGTFPGHAIEYLGRSDHQVKVRGLRIELGEIDAALNAHPDVEFAATLGYESPAETRLASH 6746 Query: 923 -LVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRR 981 LV A A D + A A+P YMVP A + IP+T +GKLDR ALPAP A + Sbjct: 6747 VLVGAGADRDPAALLAFLRQALPGYMVPSALVFLDTIPLTPNGKLDRDALPAPDFGAAAK 6806 Query: 982 ---YREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLT 1038 YREP E+ I FA++ G +G + FF GG+SL A R+ A++ A + +T Sbjct: 6807 EIVYREPRNPLEQSIADAFAEVLGGTDIGLDTDFFDAGGNSLSATRVTARVGALLDIRVT 6866 Query: 1039 VRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLS 1098 VR +F+APT LA L R D A P RP R+PLS Sbjct: 6867 VRDLFEAPTVLALAESLAPRMSEAG--------------DGASAGPALAPQPRPDRIPLS 6912 Query: 1099 HSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGV 1158 +Q WF + E + +N+P A+R GP RHE+LRT F + G Sbjct: 6913 LAQQRMWFLNQFETSSPAYNLPAAVRLTGPLDTAALAAAIDDLITRHESLRTVFPDSRGG 6972 Query: 1159 PYQIV-HPSR-TVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLL 1216 P+Q++ P + T A + + Q F L+ + LG HVL Sbjct: 6973 PHQVILEPGQFTPDTAPVRVSESGLRADLEQFLLTGFDVSQAVPLRVKVYSLGDTEHVLA 7032 Query: 1217 LIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF--ESNWG 1274 +VHHI +D S+E + D+++AY +R +AP W LP+Q+ADYA+WQR ES+ G Sbjct: 7033 FVVHHIAADGVSMEPLIRDVMIAYSSRAAGHAPSWAPLPVQYADYALWQREVLGVESDPG 7092 Query: 1275 Q---TELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNG 1331 +L+YW LAG+PD++ + DR RP V RG +F++ A AL +LA +G Sbjct: 7093 SLAAAQLEYWTRTLAGVPDQLYLPGDRGRPAVPSHRGAATRFTLDADTHRALAELARAHG 7152 Query: 1332 ATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPT 1391 A+ FM+ AAL+V+L +L +DI +G+ +A R ++G+F N +VLRT L + Sbjct: 7153 ASIFMVAHAALSVLLGRLSTSSDITVGTAIAGRGRVELDDIIGMFVNTLVLRTTLDPGAS 7212 Query: 1392 LRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQ 1434 S+L +RD L+A AH +LP ERLVE L+P R+ S +PLFQ Sbjct: 7213 FVSLLEQARDVDLEAFAHADLPFERLVEVLSPVRSTSHHPLFQ 7255 Score = 600 bits (1548), Expect = e-169 Identities = 468/1471 (31%), Positives = 685/1471 (46%), Gaps = 129/1471 (8%) Query: 38 PGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVD----EDRLHTAVNDVVARHA 93 P + LS QR MWF Q +DP+ V + I L G++D + L TA ++ + A Sbjct: 39 PDGAFPLSTAQRGMWFAQQLDPE-VPVTIAQCVELVGVLDVALLSESLITAGRELGS--A 95 Query: 94 ILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNE 153 LR V+ +G PYQ+ ++ R DL R P+ + E+ P D+ + Sbjct: 96 FLRL---VEVDGVPYQLVDPTLDASVRFVDLQREPDP--RAAAKEWMRQEYTTPLDVCRD 150 Query: 154 LPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVL 213 + V+ T D VHH+ D + + D Q + V Sbjct: 151 RLVTSAVLCTGPDRHYWYSRVHHVALD-------------GMGSMTLIDRTTQLYTAAVQ 197 Query: 214 QNSAAPSVA---------------------DVGYWAETLRXXXXXXXXXGVSGANPCRRA 252 +AAPS A D YW+E R V + P R Sbjct: 198 GRTAAPSKAAALTDVARVDDDYRISPRYRADQEYWSE--RVSTIGETHSLVERSAPARAR 255 Query: 253 QRRVR-PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA 311 R +P L +E + +S ++AA+ + R TG + VS+PVT R+ A Sbjct: 256 SRTAGGQIPGTLVDHLEAATDRHDSSTAFEVIAAFAAYLSRMTGREEVAVSLPVTARTTA 315 Query: 312 AAGALG-YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMG 370 G N + L + R T V VR A HQ + R+A E G Sbjct: 316 LLRRSGGMVSNVVPLHLHVRPDMTNADLVAAVRLEVTAALRHQRYPHIDIRRDAATEHQG 375 Query: 371 RDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQ 430 G + V L F+ + G +V +L L + L++ + S+ +++ Sbjct: 376 FYGPLINVML-FHDEITLGS------IVGRLELLSTGPITDLAVNVYHGVAGTSLNLDFE 428 Query: 431 QQLSSVLVDQMLVHYLQL-------VDKALAEPERPLSSLDILGAGERDSVLAQSHGELV 483 + H+ + + EP R + LDIL E +++ S G Sbjct: 429 ANPDLYSEGTLRAHHTRFTRFLGAFLTSDTDEPRR-VGDLDILDDDESRTLVPAS-GRAG 486 Query: 484 EMPATT---MVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPE 540 P T + +S L+Y L +NRLAR I GPE Sbjct: 487 FAPVTLPDLLGGAVRSNRDGDALVAPGHGISSADTLSYRALDEASNRLARLLIDLQVGPE 546 Query: 541 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-------G 593 ++ L + S E + ++ AV KAGAA++P+DP+ P +RI +++ D I G Sbjct: 547 VMVALALPRSRESVSSVWAVAKAGAAFVPVDPSLPADRIAFMLEDCGAPIGITTAALRDG 606 Query: 594 RPEL--------DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVS 645 PE D AA ++D+DR R L H AYVIYTSGSTGRPKGVAV+ Sbjct: 607 LPECTHWIVLDDDEFRATAAAYPPDAVTDTDRTRALSVDHPAYVIYTSGSTGRPKGVAVT 666 Query: 646 HHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDIS 705 H + +++ R L F+S SFDAS+ ++ + + GA L+V +G Sbjct: 667 HRGVVNLAADERDRLVVSSGSRVLHFASPSFDASVFELVMAVCAGATLVVAPTTIYGGTE 726 Query: 706 YVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDA 765 +A+L++ + VT LR V V G+ P E+ R+A Sbjct: 727 -LAELMAEQRVTHAFCTPAALASLDHRGLD----HLRTVVVAGDVCPPELVARWAP--GR 779 Query: 766 ELRNHYGPTEAVVCS--THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGEL 823 + N YGP+E + S T +V G + V +G P V VLD +L PVP V GEL Sbjct: 780 IMVNAYGPSETTIMSSATGPMVPG----QPVTVGSPTVGVDLVVLDHRLRPVPAGVRGEL 835 Query: 824 YLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGE----LEFVGRADE 879 Y+ GS LARGY+ R LTA+RF+A PF G R+YRTGD+VR + LEF+GR+D Sbjct: 836 YVLGSSLARGYVRRAGLTAERFVASPFGTGGRMYRTGDVVRWVTAPDGPPVLEFLGRSDF 895 Query: 880 QVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPA-AAQVDLEEIRA 937 QVKIRGFRIELGE+++ +T HP V V + +G L +Y++P A V+ + Sbjct: 896 QVKIRGFRIELGEIDAALTAHPVVEFAYTVGYDDGSGSSRLVSYVLPVPATDVETRVLSE 955 Query: 938 HTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIA-TRRYREPETATERWICSI 996 +P YMVP + ++ +P+T +GKLDR ALPAP A + P T TE + I Sbjct: 956 FVGERLPGYMVPSSIMMLDSLPLTPAGKLDRNALPAPVFAARSADIVRPRTVTEEILLGI 1015 Query: 997 FAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLV 1056 F + G + + SFF LGG+SL+A ++V+++ GV + VR +F +P+ + LA Sbjct: 1016 FRDVLGLPELSVDTSFFELGGNSLMATQVVSRVNTALGVRIGVRDLFQSPSVSQLAVP-- 1073 Query: 1057 ERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREE 1116 AA+ P +RP RP +PLS +Q WF + + A Sbjct: 1074 --------------AANTGP--QADSRPVLEARERPDHVPLSVAQQRMWFLNQFDTASPA 1117 Query: 1117 FNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAI 1176 +N+P++LR G RHEALRT F + P+Q+V P +V I Sbjct: 1118 YNLPISLRLTGALDREALRAALGDVQERHEALRTVFPDTPDGPHQLVVPVVSVLAETDPI 1177 Query: 1177 DQD--EFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFD 1234 D D T L F + L+A L PD HVL+L+VHH+ +D S+ + Sbjct: 1178 DVDAKSLTAAVTALGGAGFDLTTDTPLRAGLFREAPDRHVLVLVVHHVAADGWSMTPLAA 1237 Query: 1235 DLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLP 1289 D++VAY AR+ +AP W LP+Q+ADY +WQR S + ++ +W+ ALAG+P Sbjct: 1238 DVMVAYAARVAGHAPTWAPLPVQYADYTLWQRELLGSEDDPDSVSARQIAHWQSALAGVP 1297 Query: 1290 DEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKL 1349 + + DR RP + RG V+F++ A L LA+ G T FM+ AAL V+ H+L Sbjct: 1298 QLLELPADRPRPAEMSHRGGRVEFTITADVHGRLVDLAQSTGTTLFMVTHAALVVLFHRL 1357 Query: 1350 GGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAH 1409 G GTDI +G+PVA R E A LVG+F N +VLR T +L RD L A +H Sbjct: 1358 GAGTDIVIGTPVAGRGEEALDDLVGMFVNTLVLRATAEPGDTFEEVLDRVRDADLAAFSH 1417 Query: 1410 QELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 ++P ERLVE L+P R+ +R+PLFQ ML+F+ Sbjct: 1418 ADVPFERLVEVLSPDRSAARHPLFQVMLSFQ 1448 Score = 595 bits (1533), Expect = e-167 Identities = 405/1072 (37%), Positives = 550/1072 (51%), Gaps = 64/1072 (5%) Query: 34 PGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHA 93 P + P ER LS Q RMWFL DP+ NI A RL+G +D D L AV DVV RH Sbjct: 9027 PAVRP-ERIPLSSAQHRMWFLNRFDPNSAVHNIPAAVRLSGALDVDALQHAVADVVRRHE 9085 Query: 94 ILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNE 153 LRT Y +G P+QV VG + A E + +L A FD+T E Sbjct: 9086 SLRTVYPDSADG-PHQVILPIDRVGGEMSVV-----ATDEAALPALIAGLVTTGFDVTTE 9139 Query: 154 LPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPIND 202 +P+R+ + R A E VL LVVHHI D S ++ AY LP+ Sbjct: 9140 VPVRVRIFRMSATEHVLALVVHHISGDGWSMAPMVRDVMTAYAARSADTTPDWAPLPVQY 9199 Query: 203 PAAQFLSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR-- 257 +L + P S + +W TL P + R Sbjct: 9200 ADYALWQRALLGDETDPESVSARQLAFWTHTLAGAPDQLDLP-TDRPRPAVASYRGGTVD 9258 Query: 258 -PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL 316 +PA L + AR +AS FM++ AA VL+ R +G D + PV R L Sbjct: 9259 FTVPADLHGTLLGAARDANASLFMLVHAALAVLLSRLSGTGDIAIGTPVAGRGERELDDL 9318 Query: 317 -GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM-GRDGM 374 G F NTL+LR TF V +VRET LA F+H V +R+V NP R GR + Sbjct: 9319 IGMFVNTLVLRQQVDGGRTFAELVADVRETDLAAFSHADVPFERLVEVVNPSRSTGRHPL 9378 Query: 375 DLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTI------ALDPDDVSVEFE 428 ++ N+ ++ L L + V + A L LT+ A PD ++ Sbjct: 9379 FQVMLTFQNLDQAT--LRLGDLSVSGVDFDVDIAKFDLQLTLMEQFDSAGSPDGIAARLT 9436 Query: 429 YQQQLSSVLVDQMLVH-----YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELV 483 Y +S L D+ +H + Q++ A P+ + +D+LG+GER + A ++ Sbjct: 9437 Y----ASDLFDEPSMHVFGQRFQQVLRAATDSPDTAVGDIDVLGSGERKQI-AGTNATSH 9491 Query: 484 EMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDII 543 E+PA T+ + D ELTY++ R NRLAR I QG GPE ++ Sbjct: 9492 EVPAGTLASLFDTRVAADPVRVAV--IFDRDELTYADFDARVNRLARRLIEQGVGPESVV 9549 Query: 544 GLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI----------G 593 + M SI+ +VA+ AV+KAG AYLP+DP +P ER +++ A+P V+ Sbjct: 9550 AVAMRRSIDLLVAIYAVVKAGGAYLPVDPDHPAERTAHVLDTAQPACVLVSGAGLAGGGS 9609 Query: 594 RPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHV 653 P +DVA + P++D+DRL PL P + AYVI+TSGSTGRPKGVAV+H AI + Sbjct: 9610 VPVIDVASEDVSGFDSSPVTDADRLWPLSPANTAYVIFTSGSTGRPKGVAVTHGAIVNRL 9669 Query: 654 QGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISR 713 E+T+T+ D LQ + V+FD S+ ++F L +GA L++ PD D Y+ LI Sbjct: 9670 LWMQHEYTLTSADVVLQKTPVTFDVSVWELFWPLQVGASLVIAAPDGHRDPRYLTGLIQE 9729 Query: 714 RGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGP 773 R VT LR V GEAL E RF A+L N YGP Sbjct: 9730 RHVTTTHFVPSMLSVFTAEPAVAVCDSLRLVFCSGEALTPEQVSRFRAVCGADLHNLYGP 9789 Query: 774 TEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARG 833 TEA V T+ TG+ VPIG P N +VLD +LHPVP+ V GELYL G QLARG Sbjct: 9790 TEAAVDVTYWE-TGAADTVTVPIGRPVWNTQVHVLDSRLHPVPNGVAGELYLAGDQLARG 9848 Query: 834 YLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEV 893 YL RP L+A RF+A+P G R+YRTGDLVRR G LE+VGR D QVK+RG RIELGE+ Sbjct: 9849 YLNRPDLSADRFVANPHVAGGRMYRTGDLVRRRADGVLEYVGRTDFQVKLRGQRIELGEI 9908 Query: 894 ESVITTHPAVRHCLVVAEETEAG-PMLAAYLV-PAAAQVDLEEIRAHTAAAVPEYMVPGA 951 E+ + HP V +VV + G L AYLV P AA D ++RAH +A VP YM+P Sbjct: 9909 EAALEAHPDVSQAVVVVHRDDRGEEALVAYLVGPRAA--DWSDVRAHLSARVPSYMIPAQ 9966 Query: 952 FAVIPEIPMTVSGKLDRRALPAPTP-IATRRYREPETATERWICSIFAQLFGRQRVGAED 1010 + +P++ +GKLDR ALPAP A Y+ P TA ER + ++FA + G RVG D Sbjct: 9967 VVHLDTLPLSANGKLDRTALPAPAARSAADEYQAPRTAAERAVATVFADVLGIDRVGVTD 10026 Query: 1011 SFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRND 1062 SFF LGG+SL+A R+ + + +E G+D ++ +F PTP L R ++++ ND Sbjct: 10027 SFFDLGGNSLIATRVASALGSELGIDFPLQWMFSDPTPQSLGQR-IQKWTND 10077 Score = 535 bits (1379), Expect = e-149 Identities = 469/1465 (32%), Positives = 673/1465 (45%), Gaps = 124/1465 (8%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS QRRMWF+ D N+ A RL+G++D D L +A+ DV+ RH LRT Y Sbjct: 2157 RIPLSPAQRRMWFVNQFDTASAAYNMPFALRLSGILDCDGLRSAIRDVLERHESLRTLYP 2216 Query: 101 VDTEGEPYQVF--SDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRI 158 T+G P+QV +D+V + D+ + EA ++ LA + F D+T+ +PLR Sbjct: 2217 DSTDG-PHQVIVGADEVPLDL---DVQPITEAELPTRLVELATEGF----DVTSAVPLRT 2268 Query: 159 TVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-------------DLPINDPA- 204 ++R DE VL +VVHHI D S ++ AY D+ D + Sbjct: 2269 ALLRLSVDEYVLAVVVHHISADGSSMAPLARDILLAYTARTAGRAPSWPPLDVQYADYSY 2328 Query: 205 --AQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLP 260 A+FL E S A + +W+ L A P + Sbjct: 2329 WQAEFLGDETDGRSQATE--QIEFWSAALDGIPDLLELPADRPRPAMPTNSGATVPFSVD 2386 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A V D A + +A+PFMV AA VL+ R + A D V PV R+ + L G F Sbjct: 2387 AATAKAVADLAARSAATPFMVWHAALSVLLSRLSNAVDVTVGTPVAGRAEPSLQDLVGMF 2446 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVR 379 NTL LR +F + +VRE LA FAH + +R+V P R L + Sbjct: 2447 VNTLTLRARVSGDLSFADLLAQVREFDLAAFAHADLPFERLVEVLEPARS--TARHPLFQ 2504 Query: 380 LGFNMRK-SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD------VSVEFEYQQQ 432 +G + G L L G+ V + + A L++T+ D+ ++ F Y Sbjct: 2505 VGLSYENFEPGVLELPGLTVSAVEMNPEIAKFDLNVTLTEIRDERGTVSGLTGAFTYAVD 2564 Query: 433 L-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMV 491 L V+ + ++V ALA+P + L +L E VL + + VE+ + Sbjct: 2565 LFDRDTVESFADRFARIVTAALADPGTAVGDLPVLDQRELVRVLREWNATDVEVSGRPYL 2624 Query: 492 KXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSI 551 V + +TY E + R NRLAR I +G G E + + SI Sbjct: 2625 ARYDEQAARTPDAVAV--VYRDVSVTYREFNSRVNRLARKLIAEGAGTETTVAVAARRSI 2682 Query: 552 EFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI----GRPELDVAERAAADN 607 EF++A+ AVL++GAAY+P+D P ER+ ++I A P V+ G E D R + Sbjct: 2683 EFLIALHAVLRSGAAYVPLDVDLPAERVAHVIEAAHPVLVLTAVRGEFESDSGVRVLPID 2742 Query: 608 S-------DLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW 660 D P+++ DRLRPL +LAYVI+TSGSTGRPKGVAVSH + H + ++ Sbjct: 2743 GLELDRFDDAPVTNRDRLRPLAADNLAYVIFTSGSTGRPKGVAVSHAGLGSHFEFLMSLC 2802 Query: 661 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXX 720 + DR + + SFDASL ++ L +GA++++ +PD D Y+A+LI +T Sbjct: 2803 ALDETDRVVVKTPQSFDASLWELLWPLAVGARVVIAEPDGHKDPDYLAELIDTEQITAIH 2862 Query: 721 XXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS 780 ++ LR V VGGEAL VA RFA DA + N YGP E S Sbjct: 2863 FVPSMLAVFTDVIAPSRFSSLRTVFVGGEALSVNVARRFAAVSDAAVLNAYGPAEVAAAS 2922 Query: 781 THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTL 840 T V S+ A +V +G P N AYVLD++LHP P V GELYL G+Q++RGY GRP L Sbjct: 2923 TTSWVDTSNSA-IVTVGTPVWNTRAYVLDQRLHPSPAGVTGELYLAGTQVSRGYAGRPDL 2981 Query: 841 TAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITT 899 TA+RF+A+PF+ PG R+YRTGD +R GELE++GR D QVK+RG RIELGE+E+V+ + Sbjct: 2982 TAERFVANPFDAPGTRMYRTGDRLRWTGRGELEYLGRNDFQVKLRGLRIELGEIEAVLES 3041 Query: 900 HPAVRHCLVVAEETEAGPMLAAYLVP-AAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEI 958 +V +V A L AYLV A +VD+E + A+ A+ +PEYMVP F + Sbjct: 3042 ADSVAQAVVTVYSGAASEQLVAYLVARAGTRVDIEALTAYAASRLPEYMVPDGFVTLDAF 3101 Query: 959 PMTVSGKLDRRALPAPT--PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLG 1016 P+ SGKLDR ALPAP +A R EP T E + ++F + G +G DSFF LG Sbjct: 3102 PLNASGKLDRVALPAPAVGDVAVDRV-EPRTPMEESLAALFREALGVDDLGVNDSFFALG 3160 Query: 1017 GHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMP 1076 G S+++ +LV++ +A G+ T R +F+ + A LA V + L L LA + Sbjct: 3161 GDSIVSIQLVSRAKAA-GIVFTPRDVFERKSIAALAE--VVTVASADRLALAELAGGGV- 3216 Query: 1077 LDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXX 1136 G V+ R L S G+ ++ + L Sbjct: 3217 --------GNVELTPVVRSLLDRS-----------GSVGRYSQSVLLTLPTGIERSDIVA 3257 Query: 1137 XXXXXXXRHEALRTNF------DEHEGVPYQIVHPSRTV-------QLAVRAIDQDEFDD 1183 RH+ALR+ H +P V R V L A D + Sbjct: 3258 TVQAVLDRHDALRSRLVRDGADVRHSVLPTGAVDADRLVTTVSVNPDLGDAAFDALIDRE 3317 Query: 1184 VSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIV-HHIVSDHASLEIVFDDLIVAYRA 1242 +S R F E+ L Q L G LL+V HH+V D S I+ DL+ A A Sbjct: 3318 LSAAADRFDF--ETPVLTQFVWLDRGATRPGRLLVVAHHLVVDGVSWRIIVPDLVAAGGA 3375 Query: 1243 RLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT---ELDYWRDAL-AGLPDEISVATDR 1298 +AP LP W E+ + + DYWR + A P A D Sbjct: 3376 VAAGHAPN---LPEVGTSLRRWSHGLSEAARQPSTVAQFDYWRSVVDAADPLLGGRALDP 3432 Query: 1299 ARPRVLGKRGEVVQFSVPAARRAALTQLAERNGAT--EFMLYQAALAVVLHKLGGGTDIA 1356 R R + V+ S L ++ E G + + +L A+A+ + G A Sbjct: 3433 VRDRTSTTQELHVELSTEIT-ATLLARVPEAFGCSVGDSLLAGFAVALTEWRRARGVPAA 3491 Query: 1357 L------GSPVAARVEPAT--AQLVGLFANVVVLRTDLSGDPTLRSILVG-SRDTVLDAL 1407 G V P ++ VG F +V +R L G T +++ G S + A+ Sbjct: 3492 SAYITLEGHGREESVVPGADLSRTVGWFTSVYPVRLALEGVDTQDALVGGASAGAAIKAV 3551 Query: 1408 AHQELPIE------RLVEALNPPRA 1426 Q L + L+ LNP A Sbjct: 3552 KEQLLAVPDRGVGYGLLRYLNPATA 3576 Score = 55.8 bits (133), Expect = 5e-05 Identities = 29/77 (37%), Positives = 47/77 (61%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E L A+ E L + + ++++FALGGDSI++I+ ++A A G+ F P VFE +IA Sbjct: 3134 EESLAALFREALGVDDLGVNDSFFALGGDSIVSIQLVSRAKAAGIVFTPRDVFERKSIAA 3193 Query: 1620 LAAAVDAANGEPVVEAD 1636 LA V A+ + + A+ Sbjct: 3194 LAEVVTVASADRLALAE 3210 Score = 39.3 bits (90), Expect = 4.9 Identities = 26/88 (29%), Positives = 47/88 (53%), Gaps = 6/88 (6%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E + A ++L + I D+N+FALGG+S+ A + ++ G A G +F++ T+ Sbjct: 5743 EIAVAAAFADVLGESRIGVDDNFFALGGNSLSATQVVSRVGSAFGTRVSVRTLFDNPTVR 5802 Query: 1619 ELAAAV-----DAANGEPVVEADPPPAQ 1641 +L +AV DA++G P + P + Sbjct: 5803 QLVSAVATSGPDASSGRPALTRREHPGR 5830 Score = 38.9 bits (89), Expect = 6.4 Identities = 30/89 (33%), Positives = 46/89 (51%), Gaps = 5/89 (5%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGAL-GLPFPPAMVFEHMT 1616 E ER + A+ ++L + + +N+F LGG+S+ + +A+ G L G VF T Sbjct: 4681 EAERTVAAVFADVLGSSRVGAHDNFFDLGGNSLSVTRVAARLGELSGTGLSVRDVFTAPT 4740 Query: 1617 IAELA---AAVDAANG-EPVVEADPPPAQ 1641 +AELA A AA G PV+ PA+ Sbjct: 4741 VAELARRLAEPTAAGGARPVLSGMQRPAR 4769 Score = 38.9 bits (89), Expect = 6.4 Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 7/88 (7%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMTI 1617 TE + A+ ++L + + N+F LGG+S++A + A+ + LG +FE T+ Sbjct: 8946 TEEAVAAVFADVLGVDQVGTAANFFDLGGNSLVATRVVARLSERLGCRVEIRTLFEAPTV 9005 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTP 1645 A LAA +D+ ++A P TP Sbjct: 9006 AALAALLDS------IDATAPARPALTP 9027 >tr|C1AZY4|C1AZY4_RHOOB Tax_Id=632772 SubName: Full=Putative non-ribosomal peptide synthetase;[Rhodococcus opacus] Length = 11247 Score = 789 bits (2037), Expect = 0.0 Identities = 532/1482 (35%), Positives = 749/1482 (50%), Gaps = 94/1482 (6%) Query: 23 SGLAA------EQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLA 73 +GLAA E +P + P ER LS Q RMWF+ DPD NI +A RL Sbjct: 7073 AGLAARIATPDENVRPRPALAPRERSAFVPLSLAQSRMWFINRFDPDSPAYNIPLAVRLT 7132 Query: 74 GLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLP--EAG 131 G +D D L +AV DV+ RH LRT Y +G P+QV +V D+ +P EA Sbjct: 7133 GALDVDALQSAVFDVLGRHESLRTIYPDSADG-PHQVVLPTAQVPI---DVAPVPVTEAE 7188 Query: 132 HERQIESLAADEFGRPFDLTNELP-LRITVIRTRADELVLLLVVHHICWDDDSWEVFFGE 190 +Q+ + A F D+T ++P +R+ + + VL LVVHH+ D +S F + Sbjct: 7189 LRKQLTEMVATGF----DVTADIPPMRVRLFEVGPQDYVLALVVHHVSTDGESTAPFVRD 7244 Query: 191 LSAAYND-----------LPINDPAAQFLSVEVLQNSAAPS---VADVGYWAETLRXXXX 236 + AY LP+ E+L + P A +G+W +TL Sbjct: 7245 VMVAYASRAAGREPGFAPLPVQYADYAIWQRELLGSEDDPDSLIAAQLGFWTKTLAGVPD 7304 Query: 237 XXXXXGVSGANPCR--RAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYT 294 P + R R + A + + AR+ +AS FM + AA+ VL+ R + Sbjct: 7305 LLELPVDRPRPPVQSLRGSRIDFTVDAEVHRGLAALARRHNASVFMAVHAAFAVLLSRLS 7364 Query: 295 GASDFLVSVPVTERSGAAAG-ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQ 353 G D V P+ R +G F NTL LR+ + TF ++ RE L F+H Sbjct: 7365 GTEDIAVGTPIAGRGERELDDVVGMFVNTLALRVQVDGRQTFDEILDRAREADLEAFSHA 7424 Query: 354 SVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLS 413 V +R+V NP R V F A L L + V L + A L Sbjct: 7425 DVPFERLVEVLNPARSMAHHPIFQVGYSFQNTTKAE-LELPDLTVTPLDVEGDTAQFDLH 7483 Query: 414 LTIALDPD--DVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGE 470 L + P+ +S F + L + V + + +++ A+ P + L + G+ E Sbjct: 7484 LILGDSPEGEQMSGVFTFATDLFDAATVQRFADMFRRVLAAAVDSPRTAVGDLPLAGSDE 7543 Query: 471 RDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLAR 530 R V++ + +P TT+ VSD LTY+E R N+LAR Sbjct: 7544 RALVVSGWNDTAQPLPETTLADMFAAAAAENPDVTAL--VSDGESLTYAEFSARVNQLAR 7601 Query: 531 WFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQT 590 +G+G GPE ++GL + S+E +V M A+ AG AYLPIDP +P ER Y++ A+P Sbjct: 7602 HLVGRGVGPETVVGLAIPRSVELLVGMYAITAAGGAYLPIDPDHPAERTAYVLESAQPVC 7661 Query: 591 VIGRPEL------DVAERAAADNSDL------PLSDSDRLRPLRPGHLAYVIYTSGSTGR 638 V+ ++ DV + D DL PL+DS+R+ PLRP + AYVIYTSGSTGR Sbjct: 7662 VLTTRDVAGGLPGDV-DYLFLDELDLGGIDPAPLADSERIAPLRPQNAAYVIYTSGSTGR 7720 Query: 639 PKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKP 698 PKGVA++H AIA ++ AE+ +TA+D L ++ +FD S+ + + L GA+L+V P Sbjct: 7721 PKGVAIAHGAIANQLRWKQAEYPLTADDSVLLKTAATFDLSVWEFWWALTAGARLVVATP 7780 Query: 699 DAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADR 758 D D SY+A L++ + V+ Q LR V GEALP + R Sbjct: 7781 DGHRDPSYLAGLVAEQQVSTVHFVPSLLSAFVAVAEPAQLVSLRRVLCIGEALPADTVLR 7840 Query: 759 FAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQ 818 F DAE+ N YGPTEA V TH V PIG P N YVLD +LHPVP Sbjct: 7841 FRDICDAEIFNLYGPTEAAVSVTHYRCRDERDGSV-PIGRPEWNTQTYVLDSRLHPVPAG 7899 Query: 819 VIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRA 877 V GELYL G QLARGY GR LTA+RF+A PF G R+YRTGDLVR N G+L++VGR+ Sbjct: 7900 VTGELYLAGEQLARGYFGRHDLTAERFVASPFGVAGARMYRTGDLVRWNRDGDLDYVGRS 7959 Query: 878 DEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVPAAAQ-VDLEEI 935 D QVK+RGFRIELGE+E + HPAV +VV + G L Y+VP VD ++ Sbjct: 7960 DFQVKVRGFRIELGEIERALVAHPAVAQAVVVVHHDRHTGDRLVGYVVPEPGDSVDDADV 8019 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPT-PIATRRYREPETATERWIC 994 A +VP YMVP A + E+P+ ++GKLDR+ALP P A YR P T E + Sbjct: 8020 LAFAGKSVPGYMVPSALIALDELPLNINGKLDRKALPEPEFGGAADHYRAPRTPVEEIVA 8079 Query: 995 SIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAAR 1054 +FA + G +RV A+ SFF LGG+SL+A R+VA+I A + VR +F+APT L+AR Sbjct: 8080 GVFADVLGHERVSADTSFFDLGGNSLVATRVVARINAALDTSIGVRELFEAPTVIALSAR 8139 Query: 1055 LVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAR 1114 + D+ A+ RP V RP R+PLS +Q WF + + A Sbjct: 8140 AEQS---------DSAGAN---------RPALVPQPRPTRIPLSPAQSRMWFINQFDTAS 8181 Query: 1115 EEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVR 1174 +N+PLA+R G RHE LRT + + P Q+V P+R+V R Sbjct: 8182 AAYNIPLAIRLTGRLDVAALGQALGDVVERHETLRTTYPDTGDGPGQVVLPARSV----R 8237 Query: 1175 AIDQDEFDDVSTQLRRHV------FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHAS 1228 A+D ++ D S R + F ++A LL + + HVL+++VHHI SD AS Sbjct: 8238 ALDVEDVADESALRERVISLVTAGFDVAQAVPVRARLLRIDAEQHVLVIVVHHISSDGAS 8297 Query: 1229 LEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRD 1283 + D+++AY AR + P W L +Q+AD+++WQ + ++DYWR Sbjct: 8298 TAPLARDVVIAYSARAAGSEPAWAPLDVQYADFSLWQHELLGDENAPDSLATKQIDYWRT 8357 Query: 1284 ALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALA 1343 L+GLPD + + TDR RP RG F + A R L LA + A+ FM+ AAL+ Sbjct: 8358 TLSGLPDVLPLPTDRPRPPAQSMRGANFDFEIDAELRDRLGALAREHNASLFMVAHAALS 8417 Query: 1344 VVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTV 1403 V+L +L DIA+G+ + R E A LVG+F N +VLR + + T +L R Sbjct: 8418 VLLARLSATDDIAVGTAIEGRGEAALDDLVGMFVNTLVLRAHVDVESTFADLLAQVRQHD 8477 Query: 1404 LDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWA 1445 L A H ++P ERLVE L P R+ + +PLFQ L F+ + A Sbjct: 8478 LGAFTHTDVPFERLVEILQPERSTAFSPLFQVALAFQNIEQA 8519 Score = 683 bits (1763), Expect = 0.0 Identities = 492/1502 (32%), Positives = 736/1502 (49%), Gaps = 108/1502 (7%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS Q+RMWF+ DP N+ +A RL G +D L++A DVV RH LRT + Sbjct: 6042 RIPLSLAQQRMWFVNQFDPSSPAYNLPLAVRLTGSIDPAALNSAWADVVERHESLRTVFP 6101 Query: 101 VDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITV 160 VD E + +QV +V DLT P A E+ + + + FD+T +P+R+ Sbjct: 6102 VDGE-DAHQVVLPAADVV---SDLTPTPVAD-EQDLFARMRELGATGFDVTETVPVRVAC 6156 Query: 161 IRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFLS 209 + +L++VVHHI D S F ++ AY LP+ Sbjct: 6157 FEVNPTDHILMMVVHHISADGASLAPLFTDVMTAYAARAAGSAPGWEPLPVQYADYALWQ 6216 Query: 210 VEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXGVSGANPCR--RAQRRVRPLPAGLF 264 E L + + P +GYW + L P + R + A Sbjct: 6217 RESLGDESDPESLVARQLGYWQQALGGLPEVLELPTDRPRPPVQSLRGASARFSIDAQTH 6276 Query: 265 SRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTL 323 + A++ + + FMV+ AA VL+ R + +D V PV R L G F NTL Sbjct: 6277 RALLAIAQETNTTLFMVVHAALAVLLERLSSQTDVAVGTPVAGRGEQELDRLVGMFVNTL 6336 Query: 324 LLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFN 383 +LR + R DTF + +VR T L F+H V +R+V + R V L F+ Sbjct: 6337 VLRASVRPDDTFADLLAQVRATDLNAFSHSDVPFERLVEVLDVPRSTAHQPLFQVALSFD 6396 Query: 384 MRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD-----VSVEFEYQQQLSSVLV 438 +S + G+ + L A L L++ D ++ F Y + + Sbjct: 6397 NNESVR-MEFPGLEISALDAPLEVAKFDLQLSVGERYADGAAAGIAATFNYS---TDIFD 6452 Query: 439 DQMLV----HYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 +Q +V +++++ ++ + L ++IL A E+ ++ + VE P+T Sbjct: 6453 EQTVVGFADRFVRILGAVSSDRDVVLGDIEILDAAEKAAIAPVRGPKSVE-PSTL----P 6507 Query: 495 XXXXXXXXXXXXXXXVSDEA-ELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEF 553 VS + +LTY EL ++NRLAR I +G GPE+ + L + S+E Sbjct: 6508 ELLRSGVEISPDSVAVSFQGRKLTYRELDEQSNRLARVLIDRGVGPENYVALAITRSVES 6567 Query: 554 IVAMLAVLKAGAAYLPIDPAYPDERIDYLITDAR--------------PQTV--IGRPEL 597 I+ + ++ KAG AYLP+DP P ERI +++D+ P T I E Sbjct: 6568 ILGIWSIAKAGGAYLPVDPKLPFERIGEMLSDSGAVLGLTVARHHADLPGTAEWIVLDEP 6627 Query: 598 DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFV 657 + AE+ AA S + ++ +D R L H AY+IYTSGSTG+PKGV V+H +A + Sbjct: 6628 EAAEQIAA-RSAVAVAVADLRRALTVDHPAYLIYTSGSTGKPKGVVVTHRGLANLTREVR 6686 Query: 658 AEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVT 717 + ++ + R+L +S SFD S+ ++ GA L++ D +G +ADLI R V Sbjct: 6687 EHYVVSPDSRFLHVASPSFDTSVGEMLAAFSAGATLVISPADVYGG-DELADLIRREQVN 6745 Query: 718 VXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEA- 776 + V VGG+ E+ R+A E+RN YGPTE Sbjct: 6746 NVVMTPTALMTVDPDGLD----SVTSVVVGGDTCTPELVARWAP--GREMRNAYGPTETT 6799 Query: 777 -VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYL 835 +V T +V G V IG P R V + +LD +L PVP+ V GELY+ G + RGY Sbjct: 6800 VIVTITEPMVAGER----VTIGSPLRGVESLILDSRLRPVPEGVPGELYICGPSVTRGYH 6855 Query: 836 GRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVE 894 RP++TA+RF+A+PF PG R+YRTGD+VR +E+VGR+D QVK+RGFR+ELGE++ Sbjct: 6856 NRPSVTAERFVANPFGEPGARMYRTGDVVRWADGHRVEYVGRSDFQVKVRGFRVELGEID 6915 Query: 895 SVITTHPAVRHCLVVAEETEAG-PMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAF 952 + +T P + + V E AG L +Y++PA A V+ E +++ +P YMVP Sbjct: 6916 AALTAQPDIEFAVTVGRENPAGLTTLVSYVLPADGATVEPESLKSVVGETLPPYMVPSVV 6975 Query: 953 AVIPEIPMTVSGKLDRRALPAPTPI-ATRRYREPETATERWICSIFAQLFGRQRVGAEDS 1011 V+ EIP+T GKLDR LP P + A +R P T E + IFA + G ++V +DS Sbjct: 6976 IVLDEIPLTGIGKLDRARLPEPEFVSAGAEFRAPATPAEETVAGIFADVLGLEQVSVDDS 7035 Query: 1012 FFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLA 1071 FF LGG+SL A R+V++ FG+ + VR +F+APT AGLAAR+ Sbjct: 7036 FFDLGGNSLSATRVVSRAGQVFGLRIGVRELFEAPTVAGLAARIAT-------------- 7081 Query: 1072 ADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXX 1131 P + R RP R +PLS +Q WF R + +N+PLA+R G Sbjct: 7082 ----PDENVRPRPALAPRERSAFVPLSLAQSRMWFINRFDPDSPAYNIPLAVRLTGALDV 7137 Query: 1132 XXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRH 1191 RHE+LRT + + P+Q+V P+ V + V + E + + QL Sbjct: 7138 DALQSAVFDVLGRHESLRTIYPDSADGPHQVVLPTAQVPIDVAPVPVTEAE-LRKQLTEM 7196 Query: 1192 VFT----PESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHN 1247 V T P ++ L +GP +VL L+VHH+ +D S D++VAY +R Sbjct: 7197 VATGFDVTADIPPMRVRLFEVGPQDYVLALVVHHVSTDGESTAPFVRDVMVAYASRAAGR 7256 Query: 1248 APQWDILPIQFADYAVWQRNTFESNWGQ-----TELDYWRDALAGLPDEISVATDRARPR 1302 P + LP+Q+ADYA+WQR S +L +W LAG+PD + + DR RP Sbjct: 7257 EPGFAPLPVQYADYAIWQRELLGSEDDPDSLIAAQLGFWTKTLAGVPDLLELPVDRPRPP 7316 Query: 1303 VLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVA 1362 V RG + F+V A L LA R+ A+ FM AA AV+L +L G DIA+G+P+A Sbjct: 7317 VQSLRGSRIDFTVDAEVHRGLAALARRHNASVFMAVHAAFAVLLSRLSGTEDIAVGTPIA 7376 Query: 1363 ARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALN 1422 R E +VG+F N + LR + G T IL +R+ L+A +H ++P ERLVE LN Sbjct: 7377 GRGERELDDVVGMFVNTLALRVQVDGRQTFDEILDRAREADLEAFSHADVPFERLVEVLN 7436 Query: 1423 PPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPS 1482 P R+++ +P+FQ +F+ A + + TV PL V + A L + + +P Sbjct: 7437 PARSMAHHPIFQVGYSFQNTTKAELELP-----DLTVTPLDVEGDTAQFDLHLILGDSPE 7491 Query: 1483 GE 1484 GE Sbjct: 7492 GE 7493 Score = 664 bits (1714), Expect = 0.0 Identities = 485/1477 (32%), Positives = 725/1477 (49%), Gaps = 105/1477 (7%) Query: 27 AEQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHT 83 A S +P + G R R LS Q+RMWFL DP N+ + RL G +D L Sbjct: 3781 AHNGSRRPALVAGRRPRALPLSLAQQRMWFLNRFDPSSPAYNVPLTVRLRGELDVAALAA 3840 Query: 84 AVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADE 143 A++DVVARH +LRT + D+E +QV + DL P E + + Sbjct: 3841 ALSDVVARHEVLRTVFP-DSESGAHQVILPAAGI-----DLALDPVDVREEDLRDRMFEF 3894 Query: 144 FGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND------ 197 FD+T+ +P+R + R A + VL+LV+HHI D S ++ AY Sbjct: 3895 GATGFDVTDTIPVRTRLFRLGATDHVLVLVMHHIASDGASTLPLARDVMTAYAAHREGTE 3954 Query: 198 -----LPINDPAAQFLSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPC 249 LP+ +VL + P + A + +W++TL A P Sbjct: 3955 PAWPVLPVQYADYALWQRDVLGSEGDPDSLAAAQIDFWSKTLAGVPDVL-------ALPT 4007 Query: 250 RRAQRRVRPLP---------AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFL 300 R + VR + A + R+ + AR + S FMVL A+ VL+ R + ++D Sbjct: 4008 DRPRPTVRSMAGASVGFSVDADVHRRLGEVARAHNVSLFMVLHASLSVLLARLSSSTDIA 4067 Query: 301 VSVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDR 359 + V R A L G F NTL+LR +F + +VR LA F++Q V ++ Sbjct: 4068 IGAAVAGRGDEALENLVGMFVNTLVLRTEVEPGTSFADLLEQVRTQDLAAFSNQDVPFEQ 4127 Query: 360 VVREANPERMGRDGMDLLVRL-----GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSL 414 +V P R V L G + AG A G V + + L Sbjct: 4128 LVDALKPTRSTAYSPLFQVVLTHQVNGIPALEFAGLEATPGAVDVEFSKFDLTVDLRELW 4187 Query: 415 TIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSV 474 + P ++ Y ++ Q + A+A+ ++ DI +++ Sbjct: 4188 SDEGAPTGITGVLGYATEIFDAETVQGFADRFVRILAAVADGGTDVAVGDIPILDAQETA 4247 Query: 475 LAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIG 534 + + TT+V+ D +TY EL R+NRLAR I Sbjct: 4248 ELTPVRGIEGVAPTTLVELLAAAVAADPDGDAIVAGGDS--ITYRELDERSNRLARILIE 4305 Query: 535 QGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDA------RP 588 +G G E +GL + SI IV + AV K+G AY+PIDP YPDERI +++TD+ Sbjct: 4306 RGVGAETFVGLGITRSIPSIVGIWAVAKSGGAYVPIDPGYPDERIAHMVTDSGVALGLSV 4365 Query: 589 QTVIGRPELDV------AER---AAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRP 639 + +GR DV +E A+A S P+++++R + P + AYVIYTSG+TG+P Sbjct: 4366 SSEVGRLPRDVDWLVLDSEEFVDASARYSTAPVTEAERRTAVEPANSAYVIYTSGTTGQP 4425 Query: 640 KGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPD 699 KGV V+H +A + +T + R L F+S SFDAS+ ++ + + GA +++ D Sbjct: 4426 KGVVVTHRGLANFAAEQRERYRVTTDSRTLHFASPSFDASVLELLLAVGAGATMVIAPTD 4485 Query: 700 AFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRF 759 +G + L +R Q+ V GGEA+P E+A R+ Sbjct: 4486 VYGGPEFAKFLREQRVTHGFVTPSALASVDPSGLDDFQF-----VVAGGEAVPAELAARW 4540 Query: 760 AGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQV 819 A L N YGPTE + + + G V IG P R A VLD++L PVP + Sbjct: 4541 AP--GRSLFNGYGPTETTIMTNISDPMAADGP--VTIGGPIRGTSALVLDDRLRPVPVGI 4596 Query: 820 IGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGE----LEFV 874 G+LYL G LARGY R LTA RF+A+P+ PG R+YRTGD+VR + +++V Sbjct: 4597 AGDLYLSGLGLARGYHRRTPLTAGRFVANPYGAPGDRMYRTGDVVRWKKDADGALTVDYV 4656 Query: 875 GRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGP-MLAAYLVPA-AAQVDL 932 GR+D+QVK+RGFRIELGE+++V+ HPAV +G +L +Y++PA A+V++ Sbjct: 4657 GRSDQQVKVRGFRIELGEIDAVLAKHPAVDFATTSVLPGPSGDSVLVSYVLPAPGAEVNV 4716 Query: 933 EEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIAT-RRYREPETATER 991 + VP YMVP + IP+T GKLDRRALP P +A R +R TA E+ Sbjct: 4717 AGVLDFVGEFVPTYMVPSTIVTLDAIPLTPVGKLDRRALPEPEFLAEDREFRAAGTALEQ 4776 Query: 992 WICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGL 1051 + ++FA++ G +VGA+DSFF LGG+SL A R++A+I G+D VR IF+APT A L Sbjct: 4777 RVAAVFAEVLGVDQVGADDSFFTLGGNSLAATRVMARINEAVGIDAPVREIFEAPTVAQL 4836 Query: 1052 AARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIE 1111 A RL + L D ARP RP RLPLS +Q W+ R + Sbjct: 4837 ARRL------------EALGVDG------GARPPVTAGPRPDRLPLSLAQQRMWYANRFD 4878 Query: 1112 GAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQL 1171 E+N+PLALR G RHE+LRT + + PYQ+V + + Sbjct: 4879 PESAEYNIPLALRLTGALDVDALTTAIADVVTRHESLRTVYPDSVDGPYQVVLSASDTKS 4938 Query: 1172 A---VRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHAS 1228 A VR D+ E + L F + ++A L LG HVL+++VHHI +D +S Sbjct: 4939 ALDVVRVADEQELRERVVTLASAGFDVTADVPVRAALFALGEHDHVLVVVVHHISADGSS 4998 Query: 1229 LEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRD 1283 + + DL AY AR Q P + LP+Q+ D+A+WQRN S + ++ YW Sbjct: 4999 MAPLARDLFGAYGARAQGEEPGFSPLPVQYPDFALWQRNLLGSEDDPESLAGKQIAYWTH 5058 Query: 1284 ALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALA 1343 AL P+ + + DR RP V +G +++F + +L +LA+ + A+ FM+ AALA Sbjct: 5059 ALGDAPEVLDLPADRPRPAVRNPQGGLIEFEIGQDVHRSLNELAQTHQASLFMVVHAALA 5118 Query: 1344 VVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTV 1403 V+L +L DI++ +PVA R + A LVG+F N +VLRT++ + ++L +R+ Sbjct: 5119 VLLGRLSNTGDISVSTPVAGRGDRALDDLVGMFVNTLVLRTEVDQNARFSTLLTQAREVD 5178 Query: 1404 LDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 L+A + ++P E++VE L P R + PL Q ML+F+ Sbjct: 5179 LNAFGNADVPFEQIVEVLRPSRTAAYAPLAQVMLSFQ 5215 Score = 647 bits (1670), Expect = 0.0 Identities = 393/962 (40%), Positives = 533/962 (55%), Gaps = 53/962 (5%) Query: 510 VSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLP 569 VS + LTY+E +R N LAR IG G GPE + L + SI+ +VAM A+LKAG AY+P Sbjct: 5455 VSGDESLTYAEFDKRVNTLARTLIGMGVGPEVRVALAIRRSIDSMVAMYAILKAGGAYVP 5514 Query: 570 IDPAYPDERIDYLITDARPQTV--IGRPELDV-------------AERAAA---DNSDLP 611 +DP +P ER Y++ A P + + R LD+ + AAA D + +P Sbjct: 5515 LDPDHPAERTSYVLDSASPLCILTVARDALDLPAGHTVVEIDRLSGDEAAAPLGDEAAVP 5574 Query: 612 LSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQF 671 D +R LR + AYVIYTSGSTGRPKGVAVSH A+ + V ++ + A D LQ Sbjct: 5575 PGDEERRGTLRASNPAYVIYTSGSTGRPKGVAVSHAAVLNQISWIVDQYELGAHDVVLQK 5634 Query: 672 SSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXX 731 + +FD S+ ++F TL GA+L++ PD GD Y+A LI+R GVT Sbjct: 5635 TPATFDVSVWELFGTLVAGARLVIASPDGHGDPEYLAALIAREGVTATSFVPSMLSVFVG 5694 Query: 732 XXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTH-MVVTGSHG 790 LR V V GEA P A+ F G DAEL N YGPTE V +T V G G Sbjct: 5695 EAGRDDLLSLRVVLVAGEAFPPATAEAFRGLSDAELHNLYGPTEFTVHATAGQVDPGVRG 5754 Query: 791 ARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF 850 VPIG RN +VLD +L PVP V GELYL G+QLARGY+GR LT+ RF+A+PF Sbjct: 5755 T--VPIGRAVRNTDLHVLDSRLRPVPVGVPGELYLAGTQLARGYVGRSDLTSDRFVANPF 5812 Query: 851 NP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVV 909 G R+YRTGD+VRR G LE++GR+D QVK+RG RIELGEVE+ + TH ++ V Sbjct: 5813 GGHGQRMYRTGDVVRRRADGNLEYIGRSDFQVKLRGLRIELGEVEAALLTHESLAQAAVT 5872 Query: 910 AEETEA-GPMLAAYLVP-AAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLD 967 +E+ G L AY+VP + A+VD + ++ A +P YMVP V+ P+ SGKLD Sbjct: 5873 IHRSESTGENLVAYVVPRSGARVDTKSVQDAAAQVLPAYMVPARIVVLDSFPLGASGKLD 5932 Query: 968 RRALPAPT-PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLV 1026 R+ALP P Y P T E + S+FA + G RVG+ DSFF LGG+S+ A RL Sbjct: 5933 RKALPEPEFATVAVEYVAPRTPMETVVASVFADVLGADRVGSADSFFDLGGNSISATRLT 5992 Query: 1027 AQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGF 1086 A++RA G L+VR F+ PT A LAA L + RP Sbjct: 5993 ARLRAAVGAHLSVRECFENPTVAELAALL------------------ETTSGTAEQRPAL 6034 Query: 1087 VKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHE 1146 RP R+PLS +Q WF + + + +N+PLA+R G RHE Sbjct: 6035 AARPRPARIPLSLAQQRMWFVNQFDPSSPAYNLPLAVRLTGSIDPAALNSAWADVVERHE 6094 Query: 1147 ALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFT----PESGPLLQ 1202 +LRT F +Q+V P+ V + + D+ ++R T E+ P+ Sbjct: 6095 SLRTVFPVDGEDAHQVVLPAADVVSDLTPTPVADEQDLFARMRELGATGFDVTETVPVRV 6154 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYA 1262 A V P H+L+++VHHI +D ASL +F D++ AY AR +AP W+ LP+Q+ADYA Sbjct: 6155 ACFEV-NPTDHILMMVVHHISADGASLAPLFTDVMTAYAARAAGSAPGWEPLPVQYADYA 6213 Query: 1263 VWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPA 1317 +WQR + + +L YW+ AL GLP+ + + TDR RP V RG +FS+ A Sbjct: 6214 LWQRESLGDESDPESLVARQLGYWQQALGGLPEVLELPTDRPRPPVQSLRGASARFSIDA 6273 Query: 1318 ARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFA 1377 AL +A+ T FM+ AALAV+L +L TD+A+G+PVA R E +LVG+F Sbjct: 6274 QTHRALLAIAQETNTTLFMVVHAALAVLLERLSSQTDVAVGTPVAGRGEQELDRLVGMFV 6333 Query: 1378 NVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNML 1437 N +VLR + D T +L R T L+A +H ++P ERLVE L+ PR+ + PLFQ L Sbjct: 6334 NTLVLRASVRPDDTFADLLAQVRATDLNAFSHSDVPFERLVEVLDVPRSTAHQPLFQVAL 6393 Query: 1438 NF 1439 +F Sbjct: 6394 SF 6395 Score = 617 bits (1590), Expect = e-174 Identities = 450/1422 (31%), Positives = 688/1422 (48%), Gaps = 101/1422 (7%) Query: 72 LAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAG 131 L G VD RL A +VARH LRT + +G QV D V+V W DL+ E Sbjct: 1585 LGGSVDTGRLRRAAESLVARHPNLRTAFVAGDDGTGMQVVVDRVDVPWTHVDLSAASEPD 1644 Query: 132 HERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGEL 191 + ++++L FD+T +R ++ T AD + HHI D S + +L Sbjct: 1645 RDAELDALMLANRTDRFDMTAPPLVRFLLVETGADRYRFAVTNHHILLDGWSLPILIQDL 1704 Query: 192 SAAY----NDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGV-SGA 246 Y + L + P +E L SA V WA+ L + Sbjct: 1705 LTLYAVDGDALALPQPRPYRSYLEWL--SAQDPQVSVAAWAKALGGLEEPTLLAPAHTET 1762 Query: 247 NPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVT 306 P V LP L + + AR+ + ++ AA+G+++ R TG D + V+ Sbjct: 1763 APALTPGELVIDLPDDLLADMTARARELGVTMNTLVQAAWGIVLGRLTGRDDVVFGTTVS 1822 Query: 307 ERSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVRE 363 R G LG F NTL +R+ ++ D + ++ ++ H VG+ + + Sbjct: 1823 GRPPQVPGIESMLGLFINTLPVRVRVQAGDAVRTLLDRIQHEQTELLDHHHVGLTDIQQG 1882 Query: 364 ANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAV-AAHLPLSLTIALDPDD 422 +G L+V + + + A D +R L + + A H PL++ DP Sbjct: 1883 LG---LGALFDTLMVYESYPLDREALTKNSDIEGLRVLDVTSNDATHYPLAIVAMTDPRL 1939 Query: 423 VSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG-- 480 + + V++++ ++++ + + ++ +DIL ER S+LA +HG Sbjct: 1940 HLTAKFLPELFEAAEVEKIMARVVRVLGALSGDVDTRVADIDILAPDERASLLA-AHGTE 1998 Query: 481 -----ELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQ 535 L E+ A T + V+D +TY+EL R++RLAR I + Sbjct: 1999 AADPLSLPEILAATAAEHGERIAL----------VADGESMTYAELDARSSRLARVLIDR 2048 Query: 536 GFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG-- 593 G GPE + L M S+ +V AV KAG A++P+DP YP ERI +++ D+ V+G Sbjct: 2049 GVGPETSVALGMTRSLHSVVGTWAVAKAGGAFVPVDPRYPSERIAHMVADSG--AVLGLT 2106 Query: 594 ----RPEL-----------DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGR 638 R +L E A S P++DS+R ++ H AY+IYTSG+TG Sbjct: 2107 VSAQRNDLPSGVDWLALDSSECESLCAPKSPEPVTDSERTTAVQLEHAAYMIYTSGTTGL 2166 Query: 639 PKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKP 698 PKGV V+H +A + ++ R L F+S SFDAS+ ++ + GA ++V Sbjct: 2167 PKGVVVTHTGLANFSAEQRTHYGVSPSARTLHFASPSFDASVLELLLAFGCGATMVVAPA 2226 Query: 699 DAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADR 758 D FG + + ++ VT +L V VGGEA P E+ +R Sbjct: 2227 DLFGG-EELRNFLADNEVTHAFVTPAALASVEPAGLD----RLEVVVVGGEACPPELVER 2281 Query: 759 FAGYFDAELRNHYGPTEAVVCS--THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVP 816 +A + N YGPTEA V S ++M+V G+ + IG P V YVLD L PVP Sbjct: 2282 WAP--GRRMYNGYGPTEATVMSNVSNMLVPGNR----IEIGGPVCAVTVYVLDALLRPVP 2335 Query: 817 DQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVR-------RNHC 868 V GELY+ G LARGY R LT++RF+A+PF G R+YRTGD+VR R Sbjct: 2336 VGVAGELYIAGPGLARGYHDRLGLTSERFVANPFGENGSRMYRTGDVVRFVLDPGHRAGY 2395 Query: 869 GELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAA 927 G +E+VGR+D QVK+RGFRIELGE+++ + HP + + + +G L +Y++P A Sbjct: 2396 G-VEYVGRSDFQVKVRGFRIELGEIDAALAAHPDLEFAVTLGTSLPSGSTALVSYVLPTA 2454 Query: 928 -AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATR-RYREP 985 A VD+ E+ +P +MVP A V+ EIP+T +GKLDR+ALP P A + EP Sbjct: 2455 GAAVDVAEVTHFVGDTLPAHMVPSAIVVLDEIPLTTAGKLDRKALPEPDFDALQGEMVEP 2514 Query: 986 ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDA 1045 T TE + + A + G ++ +SFF LGG+SL+A + VA++ A G L VR +F+A Sbjct: 2515 RTPTEELVAGVLADVLGLAKISVAESFFDLGGNSLVATKAVARLNAAAGTRLGVRELFEA 2574 Query: 1046 PTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAW 1105 PT LA ++ E+ + RP V RP+R+PLS +Q + W Sbjct: 2575 PTVERLAVKVAEQAGTGSD------------------RPALVARPRPERVPLSMAQQSMW 2616 Query: 1106 FQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHP 1165 R + A +N+PLA+R G RHE+LRT F + PYQ V Sbjct: 2617 LMNRFDTASSAYNIPLAVRLSGALDIDAMSSAVSDVLARHESLRTVFPDSADGPYQQVVD 2676 Query: 1166 SRTV--QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIV 1223 V L + + E T+ F P L+ L +L+L+VHHI Sbjct: 2677 VAQVPFDLTPVRVPEAELHTALTEFAAEGFDVTVAPPLRIRLFATSDTEFLLVLVVHHIC 2736 Query: 1224 SDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTEL 1278 +D AS+ + D++VAY AR AP W LP+Q+ D+A+WQR+ + ++ Sbjct: 2737 ADGASMAPLARDVMVAYSARTAGAAPLWQPLPVQYPDFALWQRDVLGDPADTQSLAGKQI 2796 Query: 1279 DYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLY 1338 +W D LAG P+ I + D RP RG+ + F++ R L + + GA+ FM+ Sbjct: 2797 AHWADTLAGAPELIDLPLDHIRPARQSMRGDSIDFAITPELRHGLEAVGKDRGASLFMVT 2856 Query: 1339 QAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVG 1398 AAL +L +L DI +G+P+AAR + A LVG+F N +VLRT + + ++ Sbjct: 2857 HAALTTLLSRLSSSDDITVGTPLAARGDQALDDLVGMFVNTLVLRTQVRPGDSFAGLVDR 2916 Query: 1399 SRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 R+ L A + ++P E++VEAL R+ + +PLFQ ML+F+ Sbjct: 2917 VREGDLAAFGNSDVPFEKIVEALRIRRSAAYSPLFQVMLSFQ 2958 Score = 516 bits (1330), Expect = e-144 Identities = 359/1041 (34%), Positives = 514/1041 (49%), Gaps = 56/1041 (5%) Query: 48 QRRMWFLQTMDPDDV---TLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTE 104 Q M+F + D V T + + +R G+VD RL A ++ARHA LRT + D Sbjct: 9734 QSGMFFHSVLAEDAVDVYTAQVVLDFR--GVVDTGRLRGAAEALIARHANLRTAFVPDDS 9791 Query: 105 GEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTR 164 G QV D VE+ W DL+ L EA E +I S+ ++ FD+ +R +IRT Sbjct: 9792 GTAVQVVVDRVELPWEELDLSALSEADREERISSVLSEHRSARFDMGRPPLMRFLLIRTG 9851 Query: 165 ADELVLLLVVHHICWDDDSWEVFFGELSAAY------NDLPINDPAAQFLSVEVLQNSAA 218 + HHI D S + +L Y + LP FL+ +++ A Sbjct: 9852 ESSYRFSISNHHILLDGWSMPLLMKDLLVLYATRGDGSVLPRVRGYRDFLTWLSERDANA 9911 Query: 219 PSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASP 278 A WA L G L + + AR + Sbjct: 9912 SRSA----WAHALAGLDGPTVLAPAPGGEGRPEPAEFALHLGEVVSENLARIARDRGLTM 9967 Query: 279 FMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA---LGYFGNTLLLRITTRSQDTF 335 ++ AA+G+L+ R T + D + V+ R AG +G F NT+ +R+ +++ Sbjct: 9968 NTIVQAAWGLLLARMTASDDVVFGATVSGRPPEVAGIESMVGLFINTIPIRVRVDPRESI 10027 Query: 336 TSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM-DLLV--------RLGFNMRK 386 + ++ A F H +G+ + + A G G+ D L R G Sbjct: 10028 LGLLERLQAEQSALFDHHHIGLPEIQQIA-----GIGGLFDTLTVFESYPVDRAGLTEDS 10082 Query: 387 SAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYL 446 GL + GV + A+H PLSL +A ++ + +Y + + L L Sbjct: 10083 DIDGLRVAGVQISD------ASHYPLSL-LAQSDSELQLVLKYLPDVFGAETVERLGSRL 10135 Query: 447 QLVDKALAEPERPL-SSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXX 505 + + +A L LD+L ERD VL+ + ++ ++V Sbjct: 10136 NRILQTIAAGSSTLVGDLDLLAPDERDLVLSGWNDSSRDVAEESVVSMFGAQVARTPDRT 10195 Query: 506 XXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGA 565 V+D LTY+E R NRLAR I G GP+ ++G+ M S++ + ++ AV AG Sbjct: 10196 AV--VADHVRLTYAEFDARVNRLARHLIAMGVGPDTVVGIAMRRSLDMLTSLYAVHAAGG 10253 Query: 566 AYLPIDPAYPDERIDYLITDARPQTV------IGRPELDVAERAAAD-----NSDLPLSD 614 AY+PIDP +P +R Y++ A P V I ++DV D D P+ D Sbjct: 10254 AYVPIDPEHPADRTSYVVDSATPTCVLSSADDIANLDVDVPVYLVEDFDLSGYGDGPVED 10313 Query: 615 SDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSV 674 ++RL LRP +LAY +YTSGSTGRPKGVA+ H A+A + + + A+D LQ + Sbjct: 10314 TERLGELRPHNLAYALYTSGSTGRPKGVAIPHSALANQLAWMRDVYGIDAQDVVLQKTPF 10373 Query: 675 SFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXX 734 +FDAS+ ++F+ L +G L++ PD D Y+A + VTV Sbjct: 10374 TFDASVWELFLPLVVGGTLVIASPDGHRDPEYMAATVDTESVTVIQFVPSVLTMFLDAVT 10433 Query: 735 XXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVV 794 LR V GGE LP A+R AG AEL N YGPTE + ST VV S A + Sbjct: 10434 ADGCGSLRLVFAGGEPLPQSAAERVAGLGSAELVNLYGPTEVTINSTAHVVELSGTATIA 10493 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF-NPG 853 PIG P N AYVLD L+P P V GELYL G+QLARGY+ L+A+RF+A+PF +PG Sbjct: 10494 PIGSPAWNTRAYVLDAHLNPAPIGVPGELYLDGAQLARGYVNSAALSAERFVANPFGDPG 10553 Query: 854 MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEET 913 +R+YRTGDLVR N G LEFVGR D QVK+RG RIELGEVE H V V+ + Sbjct: 10554 VRMYRTGDLVRWNEGGVLEFVGRTDFQVKVRGLRIELGEVEEAFVRHGDVAQAAVIVHNS 10613 Query: 914 EAGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALP 972 E G L AY+VP + +D + A A ++PEYM+P + V+ E+P+ SGKLDRRALP Sbjct: 10614 EVGARLVAYVVPRPDSAIDQAALNAFVAESLPEYMIPDSVMVLAELPLGTSGKLDRRALP 10673 Query: 973 APTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 P + +R P T TER + S+F +L GR+ +G +DSFF LGG S+++ +LVA+ RA Sbjct: 10674 VPDFASAAEFRPPRTDTERALASVFGELLGRESIGIDDSFFELGGDSIVSIQLVARARAA 10733 Query: 1033 FGVDLTVRTIFDAPTPAGLAA 1053 G+ T R +F+ T A LAA Sbjct: 10734 -GIHFTARDVFERRTVAELAA 10753 Score = 503 bits (1295), Expect = e-140 Identities = 329/952 (34%), Positives = 487/952 (51%), Gaps = 55/952 (5%) Query: 520 ELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERI 579 E++RRAN+LAR + +G P+D++ L S+E+++ M+A K GAAY P D + ERI Sbjct: 3218 EVNRRANQLARELVSRGVRPDDVVALLTPRSLEWVIGMIAAWKVGAAYSPFDQKWAIERI 3277 Query: 580 DYLITDARPQTVIGRPELDVAERAAADNSDLP----LSDSDRLRPLRP------------ 623 L+ D+ + V+ A N+ L L D + +R L Sbjct: 3278 TGLVEDSGTRAVVATRSWSGLTGAPTGNAALDDPIVLDDPETVRHLETLDGTDFPHDPWS 3337 Query: 624 -----GHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDA 678 L +VI TSGSTGRPK V ++ + Q + + + L +S FD Sbjct: 3338 DEHAGKRLGHVISTSGSTGRPKPTMVPMLGLSNNYQSYQGDLRVKDGTGLLIANSPLFDQ 3397 Query: 679 SLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQW 738 + +I+V L G L + D F D + +I V + Sbjct: 3398 TQKNIWVGLAYGGVLHLAD-DGF-DPGPILRMIGTGDVQITNLAPSAFEVLTELDTEGVL 3455 Query: 739 RQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEA-VVCSTHMVVTGSHGARV--VP 795 L+ + +GGE L G D+ + N+YGPTEA V CS++ + + A VP Sbjct: 3456 PNLKVILLGGEMLRPAACTALIGT-DSRVLNNYGPTEASVTCSSYELDLSTADAEKWPVP 3514 Query: 796 IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGM 854 G R V +VLD ++ PVP V G+LY+GG LARGY TA RF+A+PF PG Sbjct: 3515 FGTAFRGVRYHVLDGRMRPVPPGVTGDLYIGGQVLARGYGNMFGTTASRFVANPFEGPGA 3574 Query: 855 RLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE 914 R+YRTGD VR G L FVGR+D QVKIRG RIELGE+ES +T + AV+ +VV ++E Sbjct: 3575 RMYRTGDRVRELDHGGLVFVGRSDFQVKIRGLRIELGEIESALTANSAVQKSVVVVHDSE 3634 Query: 915 AGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPA 973 GP L AY+ A A++D + +P +M+P V+ E+P+ + K+DR+ALP Sbjct: 3635 QGPRLVAYVTATAGAELDADATVEALLDVLPSHMIPDTVMVLDEMPLNANLKVDRKALPE 3694 Query: 974 PT-PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 P T + P T E + IF + RV ++SFF LGG+SL A R+ A++ + Sbjct: 3695 PVFTTGTVEFVAPRTPLEEVVAGIFGDVISVPRVSVDESFFDLGGNSLSATRVAARVTSA 3754 Query: 1033 FGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARP 1092 G ++ +R +F+APT A LA + +R N RP V RP Sbjct: 3755 TGTEVGIRDLFEAPTVATLAKLVEDRAHNGSR------------------RPALVAGRRP 3796 Query: 1093 QRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF 1152 + LPLS +Q WF R + + +N+PL +R G RHE LRT F Sbjct: 3797 RALPLSLAQQRMWFLNRFDPSSPAYNVPLTVRLRGELDVAALAAALSDVVARHEVLRTVF 3856 Query: 1153 DEHEGVPYQIVHPSRTVQLAVRAIDQDEFD--DVSTQLRRHVFTPESGPLLQANLLVLGP 1210 + E +Q++ P+ + LA+ +D E D D + F ++ L LG Sbjct: 3857 PDSESGAHQVILPAAGIDLALDPVDVREEDLRDRMFEFGATGFDVTDTIPVRTRLFRLGA 3916 Query: 1211 DTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFE 1270 HVL+L++HHI SD AS + D++ AY A + P W +LP+Q+ADYA+WQR+ Sbjct: 3917 TDHVLVLVMHHIASDGASTLPLARDVMTAYAAHREGTEPAWPVLPVQYADYALWQRDVLG 3976 Query: 1271 S-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQ 1325 S + ++D+W LAG+PD +++ TDR RP V G V FSV A L + Sbjct: 3977 SEGDPDSLAAAQIDFWSKTLAGVPDVLALPTDRPRPTVRSMAGASVGFSVDADVHRRLGE 4036 Query: 1326 LAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTD 1385 +A + + FM+ A+L+V+L +L TDIA+G+ VA R + A LVG+F N +VLRT+ Sbjct: 4037 VARAHNVSLFMVLHASLSVLLARLSSSTDIAIGAAVAGRGDEALENLVGMFVNTLVLRTE 4096 Query: 1386 LSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNML 1437 + + +L R L A ++Q++P E+LV+AL P R+ + +PLFQ +L Sbjct: 4097 VEPGTSFADLLEQVRTQDLAAFSNQDVPFEQLVDALKPTRSTAYSPLFQVVL 4148 Score = 487 bits (1254), Expect = e-135 Identities = 441/1447 (30%), Positives = 654/1447 (45%), Gaps = 132/1447 (9%) Query: 27 AEQS----SDQPGICPGER---YRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 AEQS +++P + P R LS Q RMWF+ D NI +A RL G +D Sbjct: 8140 AEQSDSAGANRPALVPQPRPTRIPLSPAQSRMWFINQFDTASAAYNIPLAIRLTGRLDVA 8199 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 L A+ DVV RH LRTTY DT P QV V + A ER I + Sbjct: 8200 ALGQALGDVVERHETLRTTYP-DTGDGPGQVVLPARSVRALDVEDVADESALRERVISLV 8258 Query: 140 AADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP 199 A FD+ +P+R ++R A++ VL++VVHHI D S ++ AY+ Sbjct: 8259 TAG-----FDVAQAVPVRARLLRIDAEQHVLVIVVHHISSDGASTAPLARDVVIAYSARA 8313 Query: 200 I-NDPAAQFLSV----------EVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSG 245 ++PA L V E+L + AP + + YW TL Sbjct: 8314 AGSEPAWAPLDVQYADFSLWQHELLGDENAPDSLATKQIDYWRTTLSGLPDVLPLPTDRP 8373 Query: 246 ANPCR--RAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSV 303 P + R + A L R+ AR+ +AS FMV AA VL+ R + D V Sbjct: 8374 RPPAQSMRGANFDFEIDAELRDRLGALAREHNASLFMVAHAALSVLLARLSATDDIAVGT 8433 Query: 304 PVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVR 362 + R AA L G F NTL+LR + TF + +VR+ L F H V +R+V Sbjct: 8434 AIEGRGEAALDDLVGMFVNTLVLRAHVDVESTFADLLAQVRQHDLGAFTHTDVPFERLVE 8493 Query: 363 EANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIA----L 418 PER V L F + A L L G+ V L G AA L LT+A + Sbjct: 8494 ILQPERSTAFSPLFQVALAFQNIEQAH-LELPGLTVEGLDGGINAAKFDLQLTLADAAGV 8552 Query: 419 DPD-DVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA 476 D D + F Y L + + ++++ + + +D+L E +VLA Sbjct: 8553 DGDAPMRGVFTYATDLFDERTIASFAFRFQRILEAITTDASVLIGDIDVLSENEH-AVLA 8611 Query: 477 QSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQG 536 G + A M+ DE ++TY EL R+NRLAR IG+G Sbjct: 8612 PVRG--ADTAAPEMLPRILGAAAAVNPDAVAVVCGDE-QVTYRELDERSNRLARVLIGRG 8668 Query: 537 FGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDAR--------- 587 G +D + L + S+E I+++ AV K GAA++P+DP+YP +RI +++TD+R Sbjct: 8669 IGADDFVALALTRSVESILSIWAVAKTGAAFVPVDPSYPFDRIMHMVTDSRVEIGLTTGA 8728 Query: 588 -----PQT----VIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGR 638 P T V+G E+D A A S+ ++D+DR+RP R AYVIYTSGSTG Sbjct: 8729 HVGELPDTVRWLVLGGDEMD---DACASVSNDAVTDADRIRPTRVDDAAYVIYTSGSTGL 8785 Query: 639 PKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKP 698 PKGV V+H +A V +T + R L F+S SFDAS+ ++ + + +++ Sbjct: 8786 PKGVVVTHTGLANVTTEQVERLRLTPQSRVLHFASPSFDASVFELLHAVAAASTMVIASG 8845 Query: 699 DAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADR 758 +G +A L+ ++ VT ++ + V GEA P E+ + Sbjct: 8846 VVYGG-DELARLLKKQKVT----HAFITPAALTTVDPAGLERVEVLSVAGEACPPELMQK 8900 Query: 759 FAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQ 818 +A + N YGP+EA + ST R V IG P R V VLD +L PVP Sbjct: 8901 WAP--GRRMFNLYGPSEATIWSTSS--NPMRADRPVTIGGPTRGVDVVVLDSRLTPVPVG 8956 Query: 819 VIGELYLGGSQLARGYLGRPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGE-----LE 872 V GELY+ G +ARGY R LTA+RF+A+PF PG RLYRTGD+VR H E L+ Sbjct: 8957 VAGELYVAGPSVARGYHNRFALTAERFVANPFGGPGERLYRTGDVVRWVHDDETGDLVLD 9016 Query: 873 FVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE--AGPMLAAYLVPAA-AQ 929 +VGR+D QVK+RGFRIELGE+++ + HP+V + + E +L +Y++PAA A Sbjct: 9017 YVGRSDFQVKVRGFRIELGEIDAELGRHPSVDFAVTLGHHREQTGQTVLVSYVMPAAGAS 9076 Query: 930 VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIA-TRRYREPETA 988 +D+ E+ A + +P YMVP + I +P+T +GKLDR+ALP P ++ Y P T Sbjct: 9077 IDVAELSAFVSETLPGYMVPSSIMAIDSVPLTPAGKLDRKALPEPQFVSVASEYTAPSTP 9136 Query: 989 TERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTP 1048 E+ I +FAQ+ G RVG +DSFF LGG S+++ +L + + GV T R +F+ T Sbjct: 9137 MEKAIADVFAQVLGVDRVGVDDSFFALGGDSIVSIQLTTRAK-NAGVLFTARDVFERKTV 9195 Query: 1049 AGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQY 1108 A LA + ++D++ +++P +PL + +A W Sbjct: 9196 AALADVAA------WATEVDSVKLEELP------------GGGVGTMPL--TPIAHWL-V 9234 Query: 1109 RIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDE-HEGVPYQIVHPSR 1167 G E+F+ + L RH+ LR+ + ++ + R Sbjct: 9235 ETAGTFEKFSQAVLLTTPPAVTRDQLADTVDAILARHDILRSRLTRVGDDWSFESLSVRR 9294 Query: 1168 TVQLAVRAIDQDEFDD------------VSTQLRRHVFTPESGPLLQ----ANLLVLGPD 1211 A I+Q EF D + P +G + Q A L Sbjct: 9295 AFD-ADELIEQIEFTDKPGTDEFERLARAALDRAADRLDPAAGRMTQFVWFAPAESLPGQ 9353 Query: 1212 THVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES 1271 + LL++ HH+V D S ++ D A + Q + + +A +S Sbjct: 9354 SGRLLVLAHHLVVDGVSWRVLLPDFATAGSQIMAGAPAQLEPVGSSVRAWAHGLAEEAKS 9413 Query: 1272 NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAE--R 1329 ELD+WR LAG I V+ + + +A LT + + Sbjct: 9414 PHRVAELDFWRGMLAGTDPLIGRRAFDPERDVIARTDRLSMTFSTQVTQALLTTIPQSVN 9473 Query: 1330 NGATEFMLYQAALAVV-LHKLGGGT---DIALGSPVAARVEPAT-----AQLVGLFANVV 1380 G + +L ALAV +L GGT + + R E A+ VG F ++ Sbjct: 9474 GGVNDGLLAALALAVSRWRELRGGTTDRSVLINLEGHGREESTVPGADLARTVGWFTSLY 9533 Query: 1381 VLRTDLS 1387 +R D+S Sbjct: 9534 PVRLDVS 9540 Score = 448 bits (1153), Expect = e-123 Identities = 409/1363 (30%), Positives = 600/1363 (44%), Gaps = 129/1363 (9%) Query: 61 DVTLNICVAYRLAGLVDEDRLHTAVNDVVARHA--ILRTTYGVDTEGEPYQVFSDDVEVG 118 DV L I L G +D D L A LR V+ EG P+Q ++ Sbjct: 3 DVPLTIAQYIELRGDIDLDLLTEATVRTGREFGSGFLRL---VEIEGMPHQYVDKSLD-- 57 Query: 119 WRREDLTRLPEAGHERQIESLAADEFGR-----PFDLTNELPLRITVIRTRADELVLLLV 173 + +T + G + ++ AA+++ R P DL + + + ++ + Sbjct: 58 ---DAITYVDLRGEDDSVD--AAEKWMRANYSAPVDLLEDRLVVVYLLHVGENHYFWFCR 112 Query: 174 VHHICWDDDSWEVFFGELSAAYNDLPIN-DPAA-------QFLSVEVLQNSAAPSVADVG 225 +HHI D ++ Y L +P A + + E ++ D Sbjct: 113 IHHIALDGFGAMALIARIAEIYTALVEGAEPPACRAEDLVRIVEDEQRYRNSDRFAKDRE 172 Query: 226 YWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAA 285 YWAE G A + A+ LP + +++ +AS V++AA Sbjct: 173 YWAERTAHLPEAPSLAG-RAAMVGKFARLSSEALPESTATLLDEALGGSNASSAPVVVAA 231 Query: 286 YGVLVRRYTGASDFLVSVPVTERSGAAAGALG-YFGNTLLLRITTRSQDTFTSFVNEVRE 344 + + T +D ++S+PV+ R+ A G N + LR+ + T V V+ Sbjct: 232 FAAYLAHMTDRTDVVLSLPVSARTTATLRRSGGMVSNIVPLRLQITPEMTVPELVKSVQI 291 Query: 345 TCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQ--LG 402 Q + + R+A + G N+ + L V Q L Sbjct: 292 ELTGALRRQRYRHEDIRRDAGAPQ----GQRGFFGPSINIMMFHSEIKLGTVTGHQNVLT 347 Query: 403 LGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVD---KAL-AEPER 458 G V L L++ + + ++FE L S D++ H+ + D + L A + Sbjct: 348 TGPVE-DLSLNIYQGVAGSKIHIDFEANPNLYSA--DELDRHHSRFFDFFERFLGAGDDA 404 Query: 459 PLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTY 518 +S L + E + V+ +G++V PA T+V V + ELTY Sbjct: 405 SVSDLATMSGEEYEQVVTGWNGDVVAPPAGTVVDLFDAQVARTPDATAL--VFEGVELTY 462 Query: 519 SELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDER 578 +E R NRLAR IG+G GPE + L + S++ +VAM AV+KAGAAY+P+DP +P ER Sbjct: 463 AEFDARVNRLARTLIGRGVGPETKVALAIRRSLDSMVAMYAVVKAGAAYVPLDPDHPAER 522 Query: 579 IDYLITDARPQTV--IGRPEL------DVAERAAADNSDL---PLSDSDRLRPLRPGHLA 627 Y++ ARP + + R L DV E A D + + P+ D +R LR + A Sbjct: 523 TAYVLESARPLCILAVSRDGLTFPAAHDVVEIDALDATGVDAGPIRDEERKAALRAANPA 582 Query: 628 YVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTL 687 YVIYTSGSTGRPKGVAVSH A+ V + + + A D LQ + +FD S+ ++F L Sbjct: 583 YVIYTSGSTGRPKGVAVSHAAVLNQVTWIASRYGLDANDVVLQKTPTTFDVSVWELFAAL 642 Query: 688 FLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVG 747 G++L++ P+ D +Y+AD+I+R+ VT Q LR V V Sbjct: 643 GSGSRLVIAAPEGHRDPAYLADVIARQNVTATSFVPSMLSVFVSEADREQLVSLRVVLVA 702 Query: 748 GEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYV 807 GEA P VA F AEL N YGPTE V +T V +PIG P N AYV Sbjct: 703 GEAFPPAVAAAFRAKSGAELHNLYGPTEFTVHATAGEV-DRESVHTIPIGTPVWNTEAYV 761 Query: 808 LDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRN 866 LD L P P GELYL G+Q+ARGY GRP LTA+RF+A+PF G RLYRTGDLV+ Sbjct: 762 LDGHLRPAPIGSAGELYLAGAQVARGYEGRPELTAERFVANPFGAAGTRLYRTGDLVKWG 821 Query: 867 HCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVP- 925 G +E++GR D QVK+RG RIELGE+ES ++++P V +VV ++ G L Y+VP Sbjct: 822 VDGSIEYLGRTDFQVKVRGLRIELGEIESAMSSYPHVAQSVVVVHDSSLGQRLVGYVVPE 881 Query: 926 AAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIA-TRRYRE 984 + + VD++++ H AVP YMVP A V+ E+P+ SGKLDR+ALP PT A + Y Sbjct: 882 SGSVVDVDDLTVHVGRAVPSYMVPDAVMVLAEMPVGASGKLDRKALPEPTFAAESSEYVA 941 Query: 985 PETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFD 1044 P + E I +FA++ G RV DSFF LGG S+++ +LV++ + E GV T R +F+ Sbjct: 942 PRSTMEESIAGLFAEVLGLPRVSIGDSFFALGGDSIVSIQLVSRAK-EAGVLFTARDVFE 1000 Query: 1045 APTPAGLA--ARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQL 1102 T A LA A+ +L MPL P + Sbjct: 1001 RKTVASLAEVAKSASESTVHVLEELPGAGIGTMPLTP----------------------V 1038 Query: 1103 AAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEH------- 1155 W + G F+ + L RH+ALR++ + Sbjct: 1039 VHWMT-ELGGDFHRFSQSILLALPPKVERERLVRTLTAVVDRHDALRSSLRRNDSPAGWS 1097 Query: 1156 -EGVPYQIVHPSRTVQ---------------LAVRAIDQ--DEFDDVSTQLRRHV-FTP- 1195 E P V R V LA A+++ D D + + R V F P Sbjct: 1098 LEVAPIGSVDVDRLVDRVEFTDGPGTGTFEALAAHALERTVDRLDPATGSVVRFVWFAPA 1157 Query: 1196 -----------ESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARL 1244 G ++A P T LL+++HH+ D S ++ D A+ Sbjct: 1158 EDSAEPAPRDAADGDTVEAE---SAPQTGRLLVVIHHLAVDGVSWRVLVPDFASAWGQIA 1214 Query: 1245 QHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVL 1304 P + +A + S EL YWR L G I R V Sbjct: 1215 AGADPLLPAVGTSVRRWAHGLADNARSARRVGELGYWRTTLDGADPLIGSRALDGRDTV- 1273 Query: 1305 GKRGEVVQFSVPA-ARRAALTQL--AERNGATEFMLYQAALAV 1344 G V+ VPA LT + A G + +L ALAV Sbjct: 1274 STTGR-VRLEVPADVTDGLLTDVPRAFHGGVNDGLLTALALAV 1315 Score = 157 bits (397), Expect = 1e-35 Identities = 161/563 (28%), Positives = 245/563 (43%), Gaps = 52/563 (9%) Query: 27 AEQSSDQPGICPG---ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHT 83 A SD+P + ER LS Q+ MW + D NI +A RL+G +D D + + Sbjct: 2588 AGTGSDRPALVARPRPERVPLSMAQQSMWLMNRFDTASSAYNIPLAVRLSGALDIDAMSS 2647 Query: 84 AVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLT--RLPEAGHERQIESLAA 141 AV+DV+ARH LRT + +G PYQ D +V + DLT R+PEA + AA Sbjct: 2648 AVSDVLARHESLRTVFPDSADG-PYQQVVDVAQVPF---DLTPVRVPEAELHTALTEFAA 2703 Query: 142 DEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN----- 196 + FD+T PLRI + T E +L+LVVHHIC D S ++ AY+ Sbjct: 2704 E----GFDVTVAPPLRIRLFATSDTEFLLVLVVHHICADGASMAPLARDVMVAYSARTAG 2759 Query: 197 ------DLPINDPAAQFLSVEVLQNSA-APSVA--DVGYWAETLRXXXXXXXXXGVSGAN 247 LP+ P +VL + A S+A + +WA+TL + Sbjct: 2760 AAPLWQPLPVQYPDFALWQRDVLGDPADTQSLAGKQIAHWADTLAGAPELIDLP-LDHIR 2818 Query: 248 PCRRAQRRVR---PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVP 304 P R++ R + L +E + AS FMV AA L+ R + + D V P Sbjct: 2819 PARQSMRGDSIDFAITPELRHGLEAVGKDRGASLFMVTHAALTTLLSRLSSSDDITVGTP 2878 Query: 305 VTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVRE 363 + R A L G F NTL+LR R D+F V+ VRE LA F + V +++V Sbjct: 2879 LAARGDQALDDLVGMFVNTLVLRTQVRPGDSFAGLVDRVREGDLAAFGNSDVPFEKIVEA 2938 Query: 364 ANPERMGRDGMDLLVRLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD 422 R V L F N R A L L G+ VR + A A L+LTI D+ Sbjct: 2939 LRIRRSAAYSPLFQVMLSFQNNRMDA--LELPGLTVRVIDDMAQGAKYDLTLTITEKADE 2996 Query: 423 ------VSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVL 475 + F + L +++ ++++++ + +P + +DIL ER + L Sbjct: 2997 SGRPAGLGGRFTFATDLFERGTAERIAERFVRILEAVVTDPGVAVGDIDILTEHER-AKL 3055 Query: 476 AQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVS---DEAELTYSELHRRANRLARWF 532 +Q+ PA TM V+ D ++TY E R ++ Sbjct: 3056 SQAR------PARTMTVRELPQLLAAAVEVAPDAVAVAHDGMQVTYREFDERLRMMSAPL 3109 Query: 533 IGQGFGPEDIIGLRMANSIEFIV 555 +G GP+ I+ + ++ + I+ Sbjct: 3110 SERGMGPDAIVSVVLSGLVPTIM 3132 Score = 142 bits (359), Expect = 3e-31 Identities = 144/548 (26%), Positives = 220/548 (40%), Gaps = 53/548 (9%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS Q+RMW+ DP+ NI +A RL G +D D L TA+ DVV RH LRT Y Sbjct: 4860 DRLPLSLAQQRMWYANRFDPESAEYNIPLALRLTGALDVDALTTAIADVVTRHESLRTVY 4919 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G PYQV + D+ R+ + E+++ FD+T ++P+R Sbjct: 4920 PDSVDG-PYQVVLSASDTK-SALDVVRVAD---EQELRERVVTLASAGFDVTADVPVRAA 4974 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFL 208 + + VL++VVHHI D S +L AY + LP+ P Sbjct: 4975 LFALGEHDHVLVVVVHHISADGSSMAPLARDLFGAYGARAQGEEPGFSPLPVQYPDFALW 5034 Query: 209 SVEVLQNSAAP-SVA--DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFS 265 +L + P S+A + YW L P R + VR GL Sbjct: 5035 QRNLLGSEDDPESLAGKQIAYWTHALGDAPEVLDL-------PADRPRPAVRNPQGGLIE 5087 Query: 266 ---------RVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL 316 + + A+ AS FMV+ AA VL+ R + D VS PV R A L Sbjct: 5088 FEIGQDVHRSLNELAQTHQASLFMVVHAALAVLLGRLSNTGDISVSTPVAGRGDRALDDL 5147 Query: 317 -GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMD 375 G F NTL+LR F++ + + RE L F + V +++V P R Sbjct: 5148 VGMFVNTLVLRTEVDQNARFSTLLTQAREVDLNAFGNADVPFEQIVEVLRPSRTAAYAPL 5207 Query: 376 LLVRLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE------FE 428 V L F N+ + L L G+ V L G + L + + DD SV F Sbjct: 5208 AQVMLSFQNLERPK--LELAGLTVEVLESGLTTSKTDLGVAVEERFDDDSVANGMRGWFS 5265 Query: 429 YQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG------- 480 Y L V ++++++ A+ + + +DIL E+ + G Sbjct: 5266 YATDLFDEATVRGFADRFVRVLEAITADADAVVGDIDILTEDEKAGLAVPDEGGQSLLAH 5325 Query: 481 ELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPE 540 + E A T + ++TY++L ++ LAR G G GPE Sbjct: 5326 SISEELAATKSLPELLDGAASINPDGIALSHNGTDVTYAQLRDKSAELARTLAGVGVGPE 5385 Query: 541 DIIGLRMA 548 + + ++ Sbjct: 5386 AAVTVALS 5393 Score = 60.8 bits (146), Expect = 2e-06 Identities = 33/79 (41%), Positives = 47/79 (59%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 +TER L ++ ELL I D+++F LGGDSI++I+ A+A A G+ F VFE T+ Sbjct: 10689 DTERALASVFGELLGRESIGIDDSFFELGGDSIVSIQLVARARAAGIHFTARDVFERRTV 10748 Query: 1618 AELAAAVDAANGEPVVEAD 1636 AELAA D+ A+ Sbjct: 10749 AELAAVADSGESAAAALAE 10767 Score = 57.4 bits (137), Expect = 2e-05 Identities = 77/318 (24%), Positives = 128/318 (40%), Gaps = 32/318 (10%) Query: 1096 PLSHSQLAAWFQYRI-EGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF-D 1153 PL+ Q +F + E A + + + L F G RH LRT F Sbjct: 9729 PLAPLQSGMFFHSVLAEDAVDVYTAQVVLDFRGVVDTGRLRGAAEALIARHANLRTAFVP 9788 Query: 1154 EHEGVPYQIVH-----PSRTVQL-AVRAIDQDE-FDDVSTQLRRHVFTPESGPLLQANLL 1206 + G Q+V P + L A+ D++E V ++ R F PL++ L+ Sbjct: 9789 DDSGTAVQVVVDRVELPWEELDLSALSEADREERISSVLSEHRSARFDMGRPPLMRFLLI 9848 Query: 1207 VLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILP--IQFADYAVW 1264 G ++ + HHI+ D S+ ++ DL+V Y R +LP + D+ W Sbjct: 9849 RTGESSYRFSISNHHILLDGWSMPLLMKDLLVLYATR-----GDGSVLPRVRGYRDFLTW 9903 Query: 1265 QRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGK-RGEVVQFSVPAARRAA- 1322 W ALAGL +A P G+ R E +F++ + Sbjct: 9904 ----LSERDANASRSAWAHALAGLDGPTVLA-----PAPGGEGRPEPAEFALHLGEVVSE 9954 Query: 1323 -LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATA---QLVGLFAN 1378 L ++A G T + QAA ++L ++ D+ G+ V+ R P A +VGLF N Sbjct: 9955 NLARIARDRGLTMNTIVQAAWGLLLARMTASDDVVFGATVSGR-PPEVAGIESMVGLFIN 10013 Query: 1379 VVVLRTDLSGDPTLRSIL 1396 + +R + ++ +L Sbjct: 10014 TIPIRVRVDPRESILGLL 10031 Score = 55.5 bits (132), Expect = 7e-05 Identities = 59/268 (22%), Positives = 111/268 (41%), Gaps = 21/268 (7%) Query: 1154 EHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGP-------LLQANLL 1206 E EG+P+Q V +++ A+ +D DD + + S P L+ LL Sbjct: 43 EIEGMPHQYV--DKSLDDAITYVDLRGEDDSVDAAEKWMRANYSAPVDLLEDRLVVVYLL 100 Query: 1207 VLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQW----DILPIQFADYA 1262 +G + + +HHI D + + Y A ++ P D++ I + Sbjct: 101 HVGENHYFWFCRIHHIALDGFGAMALIARIAEIYTALVEGAEPPACRAEDLVRIVEDEQR 160 Query: 1263 VWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAA 1322 + F + +YW + A LP+ S+A R ++GK + ++P + Sbjct: 161 YRNSDRFAK-----DREYWAERTAHLPEAPSLA---GRAAMVGKFARLSSEALPESTATL 212 Query: 1323 LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVL 1382 L + + A+ + AA A L + TD+ L PV+AR + G+ +N+V L Sbjct: 213 LDEALGGSNASSAPVVVAAFAAYLAHMTDRTDVVLSLPVSARTTATLRRSGGMVSNIVPL 272 Query: 1383 RTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 R ++ + T+ ++ + + AL Q Sbjct: 273 RLQITPEMTVPELVKSVQIELTGALRRQ 300 Score = 48.9 bits (115), Expect = 0.006 Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 5/85 (5%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E+R+ A+ E+L + + D+++F LGG+S+ A + A+ A+G+ P +FE T+A Sbjct: 4775 EQRVAAVFAEVLGVDQVGADDSFFTLGGNSLAATRVMARINEAVGIDAPVREIFEAPTVA 4834 Query: 1619 ELAAAVDA----ANGEPVVEADPPP 1639 +LA ++A P V A P P Sbjct: 4835 QLARRLEALGVDGGARPPVTAGPRP 4859 Score = 47.0 bits (110), Expect = 0.023 Identities = 24/60 (40%), Positives = 39/60 (65%), Gaps = 3/60 (5%) Query: 1565 AMLEELLEITGIDR---DENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAELA 1621 A+ + ++ G+DR D+++FALGGDSI++I+ + +A G+ F VFE T+A LA Sbjct: 9140 AIADVFAQVLGVDRVGVDDSFFALGGDSIVSIQLTTRAKNAGVLFTARDVFERKTVAALA 9199 Score = 46.6 bits (109), Expect = 0.030 Identities = 24/73 (32%), Positives = 41/73 (56%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E + + E+L + + +++FALGGDSI++I+ ++A G+ F VFE T+A Sbjct: 947 EESIAGLFAEVLGLPRVSIGDSFFALGGDSIVSIQLVSRAKEAGVLFTARDVFERKTVAS 1006 Query: 1620 LAAAVDAANGEPV 1632 LA +A+ V Sbjct: 1007 LAEVAKSASESTV 1019 Score = 41.2 bits (95), Expect = 1.3 Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 8/86 (9%) Query: 1564 TAMLEELLEITGIDR---DENYFALGGDSIIAIKWSAQA-GALGLPFPPAMVFEHMTIAE 1619 T + ++ G DR +++F LGG+SI A + +A+ A+G FE+ T+AE Sbjct: 5957 TVVASVFADVLGADRVGSADSFFDLGGNSISATRLTARLRAAVGAHLSVRECFENPTVAE 6016 Query: 1620 LAAAVDAANG----EPVVEADPPPAQ 1641 LAA ++ +G P + A P PA+ Sbjct: 6017 LAALLETTSGTAEQRPALAARPRPAR 6042 Score = 38.5 bits (88), Expect = 8.3 Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 8/105 (7%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E + + ++L + + D+++F LGG+S+ A + ++AG GL +FE T+A Sbjct: 7014 EETVAGIFADVLGLEQVSVDDSFFDLGGNSLSATRVVSRAGQVFGLRIGVRELFEAPTVA 7073 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASW 1663 LAA + P P PA P S P +LA+ S W Sbjct: 7074 GLAARI----ATPDENVRPRPA--LAPRERSAFVPLSLAQ-SRMW 7111 >tr|Q2JA66|Q2JA66_FRASC Tax_Id=106370 SubName: Full=Amino acid adenylation;[Frankia sp.] Length = 4489 Score = 788 bits (2036), Expect = 0.0 Identities = 549/1453 (37%), Positives = 734/1453 (50%), Gaps = 88/1453 (6%) Query: 33 QPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARH 92 +P + P LS GQ RMWFL + N+ +A RL G +D L A+ DV RH Sbjct: 1051 RPAVLP-----LSFGQARMWFLNRLQEGSAVYNMPMALRLRGDLDRAALRAALADVATRH 1105 Query: 93 AILRTTYGVDTEGEPYQ-VFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLT 151 LRT + D++G P+Q + + E+ + D ER++ L A E RPFD+ Sbjct: 1106 ESLRTVFP-DSDGLPFQQILAGGPELVVQDTD---------ERELPGLLAAEASRPFDVR 1155 Query: 152 NELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-LPINDPA-----A 205 +ELP R ++ E +LLLV+HHI D S V +LSAAY L +P+ Sbjct: 1156 HELPWRASLFALSPQEHMLLLVMHHIAADGWSMGVLTRDLSAAYAARLSGQEPSWAPLPV 1215 Query: 206 QFLSVEVLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR 257 Q+ V Q S D + YW TL P Sbjct: 1216 QYADFAVWQREVLGSEDDPDSLISRQLAYWRSTLAELPAELTLPVDRQRPPVASFAGGSV 1275 Query: 258 PLPAG--LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA 315 PL G + +R+ A+ A+ FMV+ AA VL+ +D + PV R AA Sbjct: 1276 PLRLGPQVHARLTGLAQDERATLFMVMQAAIAVLLSGLGAGTDIALGTPVAGRGDAAVDD 1335 Query: 316 L-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM 374 L G+F NTL+LR +F + VRE LA +AHQ V +R+V E P R Sbjct: 1336 LIGFFVNTLVLRTDLGGDPSFAELLGRVREMNLAAYAHQDVPFERLVEELQPARSLSRHP 1395 Query: 375 DLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALD--PDDVSVEFEYQQQ 432 V L F GG L G+ VR G+ A LS ++A + PD Sbjct: 1396 LFQVMLTFQNTHQDGGWELPGLSVRPERSGSDVAKFDLSFSLAENRTPDGELAGISGAVG 1455 Query: 433 LSSVLVDQMLVH-----YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPA 487 S+ L DQ +++++ A+P +S + +L ER V+ + V +P Sbjct: 1456 YSADLFDQRTAEETANRLVRVLEAVAADPTLRVSQVPLLDETERARVVDGWNETGVVVPE 1515 Query: 488 TTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRM 547 T+ + V + ++Y EL ANRLA +G G G E ++ + + Sbjct: 1516 VTLSELFEAQVRRSPGAVAL--VCEGRVVSYGELEVAANRLAWRLVGLGVGAERVVAVAV 1573 Query: 548 ANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARP-------QTVIGRPELDVA 600 A S+E +VA+LAV+KAG AYLP+DP YP R+ ++ DA P +TV G PE A Sbjct: 1574 ARSVELVVALLAVVKAGGAYLPVDPEYPASRVGLMLADADPVVVLCTAETVGGLPE-HPA 1632 Query: 601 ERAAADNSDLPLSDSDRLRP---LRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFV 657 R D+ + + D P +RPG AYV+YTSGSTG PKGV VSH I + Sbjct: 1633 VRLMVDDGGV-VRDCPGTSPGVVVRPGCPAYVMYTSGSTGVPKGVVVSHRGIVNRLLWMQ 1691 Query: 658 AEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVT 717 E+ + +DR LQ +S FD S+ + F L GA L+V +P D Y+ DL+ VT Sbjct: 1692 GEYGLGGDDRVLQKTSSGFDVSVWEFFWPLVTGACLVVARPGGHRDPRYLVDLVVAERVT 1751 Query: 718 VXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAE-LRNHYGPTEA 776 LR V GE LPGE+ +RF G L N YGPTEA Sbjct: 1752 TVHFVPSMLGLFLDEEGAALCGGLRRVVCSGEVLPGELVERFQGVLPGVGLHNLYGPTEA 1811 Query: 777 VV-CSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYL 835 V S G G VVPIG P NV +VLD L PVP V+GELY+ G LARGY+ Sbjct: 1812 SVDVSFWACPPGVSG--VVPIGGPIWNVRLFVLDGFLRPVPPGVVGELYIAGVGLARGYV 1869 Query: 836 GRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVE 894 GR +LT +RF+A PF+ G R+YRTGDLVR G L +VGR D QVKIRG RIELGEVE Sbjct: 1870 GRSSLTGERFVACPFSGSGERMYRTGDLVRWRGDGVLVYVGRVDAQVKIRGLRIELGEVE 1929 Query: 895 SVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAF 952 +V+ AV VV E + G L AY+V AA + VD +R A +PEYMVP A Sbjct: 1930 AVLAGDGAVGRVAVVVREDQPGHRYLVAYVVAAAGRGVDAAGLREFAARRLPEYMVPAAV 1989 Query: 953 AVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSF 1012 + E+P+T+SGKLDR+ALPAP R P T E +C +FA+ RVGA+D F Sbjct: 1990 VELAELPLTLSGKLDRKALPAPDFAGLVTGRAPRTPAEELLCGLFAETLHLDRVGADDDF 2049 Query: 1013 FGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAA 1072 F LGG SLLA RL+A+++A V++ +R +F APTPAG+A LA+ Sbjct: 2050 FNLGGDSLLAMRLIARVQAVLDVEVNIRELFAAPTPAGIA----------------RLAS 2093 Query: 1073 DDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXX 1132 AR V RP+ +PLS Q WF R++ +NMP+ALR G Sbjct: 2094 GG-----GSARTPLVAGQRPEEIPLSFGQTRMWFLNRLQEGSAVYNMPMALRLRGDLDRD 2148 Query: 1133 XXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV 1192 RHE LRT F + +GVP+Q + +L VRA + + D+ Sbjct: 2149 ALRAALKDVAQRHETLRTVFPDRDGVPFQKILDGGP-ELVVRATSERDLADLLAAEAARG 2207 Query: 1193 FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWD 1252 F S P +A LLVL HVLLL+VHHI +D S+ ++ DL AY ARL P W Sbjct: 2208 FDVRSEPPWRAELLVLAEREHVLLLVVHHIAADGWSIGVLTRDLSTAYAARLAGREPSWA 2267 Query: 1253 ILPIQFADYAVWQRNTFESNWG-----QTELDYWRDALAGLPDEISVATDRARPRVLGKR 1307 LP+Q+AD++ WQR S +L YWR +LAGLP E+++ DR RP V Sbjct: 2268 ALPVQYADFSAWQRQILGSEDDPDSLISRQLAYWRQSLAGLPAELTLPVDRPRPAVASFT 2327 Query: 1308 GEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEP 1367 G V V A A L +A AT FM+ QAA+A++L +LG GTDI LG+ +A R +P Sbjct: 2328 GGTVPLRVSAEAHARLAGIARDRKATMFMVVQAAVALLLSRLGAGTDIPLGTVIAGRGDP 2387 Query: 1368 ATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRAL 1427 A LVG F N +VLRTD GDP+ ++ R+ L A AHQ++P ERLVE L P R+L Sbjct: 2388 ALDGLVGFFVNTLVLRTDAGGDPSFSDLVARVREVNLAAYAHQDVPFERLVEELQPDRSL 2447 Query: 1428 SRNPLFQNMLNFR 1440 +R+PLFQ M+ F+ Sbjct: 2448 ARHPLFQVMMTFQ 2460 Score = 713 bits (1840), Expect = 0.0 Identities = 518/1476 (35%), Positives = 708/1476 (47%), Gaps = 145/1476 (9%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 E LS GQ RMWFL + N+ +A RL G +D D L A+ DV RH LRT + Sbjct: 2109 EEIPLSFGQTRMWFLNRLQEGSAVYNMPMALRLRGDLDRDALRAALKDVAQRHETLRTVF 2168 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 D +G P+Q D + A ER + L A E R FD+ +E P R Sbjct: 2169 P-DRDGVPFQKILDGGP--------ELVVRATSERDLADLLAAEAARGFDVRSEPPWRAE 2219 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-LPINDPA-----AQFLSVEVL 213 ++ E VLLLVVHHI D S V +LS AY L +P+ Q+ Sbjct: 2220 LLVLAEREHVLLLVVHHIAADGWSIGVLTRDLSTAYAARLAGREPSWAALPVQYADFSAW 2279 Query: 214 QNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLF- 264 Q S D + YW ++L P R + V G Sbjct: 2280 QRQILGSEDDPDSLISRQLAYWRQSLAGLPAELTL-------PVDRPRPAVASFTGGTVP 2332 Query: 265 --------SRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GA 315 +R+ AR A+ FMV+ AA +L+ R +D + + R A G Sbjct: 2333 LRVSAEAHARLAGIARDRKATMFMVVQAAVALLLSRLGAGTDIPLGTVIAGRGDPALDGL 2392 Query: 316 LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMD 375 +G+F NTL+LR +F+ V VRE LA +AHQ V +R+V E P+R Sbjct: 2393 VGFFVNTLVLRTDAGGDPSFSDLVARVREVNLAAYAHQDVPFERLVEELQPDRSLARHPL 2452 Query: 376 LLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVSVEFEY 429 V + F GG L G+ V+ + AA LS T+ P + Y Sbjct: 2453 FQVMMTFQTTHQDGGWELPGLSVQPQRSSSDAARFDLSFTVGEHHTAGGAPAGLDGAVGY 2512 Query: 430 QQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGE-------------RDSVL 475 L +++ ++L++ A+P S + ++ E D+ L Sbjct: 2513 SADLFDRATAEKLAGRLVRLLETVAADPALRASRVPVMDEAEWAQVVHAWNDTAWNDTAL 2572 Query: 476 AQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQ 535 S L E+ + + V + LTY+EL A RLA Q Sbjct: 2573 KVSDRTLPELFEAQVRRSPDAVAV----------VFQDVGLTYAELDAAAGRLAARLTEQ 2622 Query: 536 GFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI--- 592 G GPE ++ + + S E +VA+LAVLK GAAYLP+D YP R+ +++ DA P V+ Sbjct: 2623 GAGPERVVAVALPRSAEMLVALLAVLKTGAAYLPVDVGYPSSRVAFMLADADPAAVVCTA 2682 Query: 593 -------GRPE----LDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKG 641 G P LD A A + P + S R+ P P AYVIYTSGSTG PKG Sbjct: 2683 ETARALPGHPAVRTVLDDPRTAEAPAARQPTA-SGRIDPRHP---AYVIYTSGSTGTPKG 2738 Query: 642 VAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAF 701 V +SH + + +T D L +++ FD + ++F+ L +G +++V + + Sbjct: 2739 VVISHRNLVTFLAAMRIRPGLTEADVLLAVTTLGFDIAGLELFLPLVVGGRVVVAEREVA 2798 Query: 702 GDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQL----------RHVPVGGEAL 751 D +A I R TV WR L GGEAL Sbjct: 2799 LDPRRLAAEIVRHSATVLQATPVT------------WRMLVDDGWAGSPGLKALCGGEAL 2846 Query: 752 PGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQ 811 P ++A+ A++ N YGPTE + ST +T G V +G P YVLD+ Sbjct: 2847 PPDLAEAMIERC-AQVWNMYGPTETTIWSTCRQLTAGGG---VSLGTPIAGTRTYVLDDL 2902 Query: 812 LHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGE 870 L PVP V+GELYL G LARGY R LT +RF+A PF+ G R+YR+GDLVR GE Sbjct: 2903 LQPVPPGVVGELYLAGPGLARGYWARAGLTGERFVACPFSGSGERMYRSGDLVRWTAAGE 2962 Query: 871 LEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQ 929 L FVGRAD Q+KIRGFR+E+GEVE+V+ P V +VVA E G L Y+VP Sbjct: 2963 LVFVGRADTQLKIRGFRVEVGEVEAVLAVFPGVTRVVVVAREDRPGHRYLVGYVVPG--D 3020 Query: 930 VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETAT 989 VD +R A +PEY+VP +P +P+T +GKLDR ALPAP P TA Sbjct: 3021 VDGRAVREFAAERLPEYLVPAGVVALPALPVTPNGKLDRGALPAPDFGGLVTGGAPRTAV 3080 Query: 990 ERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPA 1049 E +CS+FA++ RVG +D FF LGG SLLA RL+A+++A V++ +R +F APTPA Sbjct: 3081 EEVLCSLFAEVLRLDRVGVDDGFFELGGDSLLAMRLIARVQAVLDVEVNIRALFAAPTPA 3140 Query: 1050 GLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYR 1109 G+A RL++ R R V++ RP +PLS+ Q WF R Sbjct: 3141 GVA-RLLD--------------------GGGRPRAALVRAVRPAVVPLSYGQTRMWFLNR 3179 Query: 1110 IEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV 1169 + +NMP ALR G RHE+LRT F + GVP Q V V Sbjct: 3180 FQEGGAVYNMPFALRLTGELDVAALRAALGDVALRHESLRTVFPDTGGVPRQEVREGSPV 3239 Query: 1170 QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASL 1229 V +D + ++ R P + +L V+ HVL+++VHHI +D S+ Sbjct: 3240 LSVVEVAAEDVPLLLRAEVGRGFDVGRELPW-RVSLFVVSAREHVLVVVVHHIAADGWSM 3298 Query: 1230 EIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF--ESNWGQ---TELDYWRDA 1284 ++ DL AY ARL AP W LP+Q+ADYA+WQR ES+ G +L YWR A Sbjct: 3299 GVLGRDLSAAYAARLSGRAPSWVGLPVQYADYALWQRAVLGSESDPGSLLSAQLGYWRSA 3358 Query: 1285 LAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAV 1344 LAGLP E+ + DR RP V RG V V A L ++A AT FM+ QAA+AV Sbjct: 3359 LAGLPVELVLPVDRPRPAVASYRGGAVPVRVGAGVHGRLVEVARAGQATLFMVVQAAVAV 3418 Query: 1345 VLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVL 1404 +L +LG G DI +G+ VA R A LVG F N +VLR L GDP+ ++ R+ L Sbjct: 3419 LLSRLGAGVDIPVGTAVAGRGAAALDDLVGFFVNTLVLRVGLGGDPSFAEVVGRVREVDL 3478 Query: 1405 DALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 A AHQ++P ERLVE + P R+L+R+PLFQ ML F+ Sbjct: 3479 AAYAHQDVPFERLVEEVQPVRSLARHPLFQVMLTFQ 3514 Score = 665 bits (1715), Expect = 0.0 Identities = 492/1410 (34%), Positives = 686/1410 (48%), Gaps = 87/1410 (6%) Query: 72 LAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEG--EPYQVFSDDVEVGWRREDLTRLPE 129 L G +D + L + ++ RHA LR + T G +P QV + V + WR D++ LP Sbjct: 41 LEGPLDAEVLRASGQAMLDRHANLRAGFR-QTAGLAQPVQVIAARVALPWREADVSALPS 99 Query: 130 AGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFG 189 AG E + + LAA++ R FD LR +IR A L++ HHI D S +F Sbjct: 100 AGAEAEADRLAAEDLDRGFDPAVPPLLRFLLIRFGARRHRLVITNHHILLDGWSLPIFKR 159 Query: 190 ELSAAY---NDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGA 246 EL Y D P + V + A + E G Sbjct: 160 ELFGVYRAGGDSSGLKPVPPYRDYLVWLSRQDRQAARAAWRRELDGKQEPTRVVVADPGR 219 Query: 247 NP--CRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVP 304 +P + R+ P P G + + A+ + V+ A+ +LV R G SD + Sbjct: 220 DPVMTELTELRLGPEPTG---ALRELAQAHGVTLNTVVQGAWAMLVSRLAGRSDVVFGAV 276 Query: 305 VTERSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVV 361 V R G LG F NTL +R+ + ++ A AHQ +G+ + Sbjct: 277 VAGRPPELPGVEDMLGLFINTLPVRVPLDPAQRVCDMLAALQARQSALTAHQYLGLAEIQ 336 Query: 362 REANPERMGRDGMDLLVRLGFNMRKSAGGLAL---DGVVVRQLGLGAVAAHLPLSLTIAL 418 REA P + D + + F+ + A D + V G G AAH PL+L I Sbjct: 337 REAGPGAV-FDTLVVYENYPFDPTVAPAAPAAADPDSLRVTSRG-GRQAAHYPLTLGIRP 394 Query: 419 DPDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQ 477 D +++ +Y+ L ++L +++++ A+P + + +LGA E V+ + Sbjct: 395 GRDGLALHVDYRPDLFDQRTAAELLARLVRILEAVAADPGVLVGRVPVLGAAEWVRVVEE 454 Query: 478 SHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGF 537 + V + T+ VS +TY EL ANR+AR + G Sbjct: 455 WNDTGVGVGVGTL--PGVFGGWVAAGRDVVAVVSGGVRVTYGELEVAANRVARDLVAAGV 512 Query: 538 GPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL 597 D +G+ M S+E + ++ V+K GAAY+P+D +P R+ ++ +A + V+ Sbjct: 513 RSGDRVGVVMERSVELVAVLVGVVKVGAAYVPVDVEWPVVRVGRVLAEAGVRVVV----- 567 Query: 598 DVAERAAADNSDLP-----------LSDSDRLRP--LRPG--HLAYVIYTSGSTGRPKGV 642 A SDLP + P +R G +AYV+YTSGSTG PKGV Sbjct: 568 -----ADVGVSDLPGSVGVVWAGGWVDGEGECGPPAVRVGADDVAYVMYTSGSTGVPKGV 622 Query: 643 AVSHHAIAEHVQGFVAE--WTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDA 700 AV+H + G A+ W+ R L +S +FDAS +++V L G Q++V P Sbjct: 623 AVTHAGVV----GLAADRCWSREVHGRVLFHASHAFDASTWELWVALLSGGQVVV-APAG 677 Query: 701 FGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFA 760 D + LIS G TV + +R V GG+ + R Sbjct: 678 RVDAGVLKGLISDFGPTVVHVTAGLFAAVAEEAPGC-FVGVREVVTGGDVVSAAAVVRVV 736 Query: 761 -GYFDAELRNHYGPTEAVVCSTHMVV-TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQ 818 +R YGPTE VC+T V G A VVPIG P N +VLD L PVP Sbjct: 737 EACPGVVVRQLYGPTEVTVCATVFEVRPGDEVASVVPIGRPMDNTRVFVLDRFLQPVPPG 796 Query: 819 VIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRA 877 V GELY+ G LARGY GRP LT +RF+A PF+ G R+YRTGDL R G+L F GR Sbjct: 797 VTGELYVAGVGLARGYFGRPGLTGERFVACPFSGSGERMYRTGDLGRWTGEGQLVFAGRV 856 Query: 878 DEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPAAAQ-VDLEEI 935 D QVK+RGFRIELGEVE+V+ +P V C+VV E E G L AY+V + + +D +I Sbjct: 857 DGQVKVRGFRIELGEVEAVLGLYPGVGRCVVVVREDEPGQKRLVAYVVASEGEALDTVQI 916 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 R A +PEYMVP V+ +P+T GK+DR ALP P R P TA E +C Sbjct: 917 RDFVAGLLPEYMVPAVVVVLSGLPLTGQGKVDRGALPVPDFAGRVGGRSPRTAVEEVLCG 976 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +FA++ +RVG EDSFF LGG SLLA RL+A++R G ++++ +F A TPAG+ ARL Sbjct: 977 LFAEVLRLERVGVEDSFFDLGGDSLLAMRLIARVRGALGAEVSIHDLFTAQTPAGV-ARL 1035 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 V AR V RP LPLS Q WF R++ Sbjct: 1036 VG--------------------GDGTARTALVAGRRPAVLPLSFGQARMWFLNRLQEGSA 1075 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRA 1175 +NMP+ALR G RHE+LRT F + +G+P+Q + +L V+ Sbjct: 1076 VYNMPMALRLRGDLDRAALRAALADVATRHESLRTVFPDSDGLPFQQILAGGP-ELVVQD 1134 Query: 1176 IDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDD 1235 D+ E + F +A+L L P H+LLL++HHI +D S+ ++ D Sbjct: 1135 TDERELPGLLAAEASRPFDVRHELPWRASLFALSPQEHMLLLVMHHIAADGWSMGVLTRD 1194 Query: 1236 LIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPD 1290 L AY ARL P W LP+Q+AD+AVWQR S + +L YWR LA LP Sbjct: 1195 LSAAYAARLSGQEPSWAPLPVQYADFAVWQREVLGSEDDPDSLISRQLAYWRSTLAELPA 1254 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 E+++ DR RP V G V + A LT LA+ AT FM+ QAA+AV+L LG Sbjct: 1255 ELTLPVDRQRPPVASFAGGSVPLRLGPQVHARLTGLAQDERATLFMVMQAAIAVLLSGLG 1314 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 GTDIALG+PVA R + A L+G F N +VLRTDL GDP+ +L R+ L A AHQ Sbjct: 1315 AGTDIALGTPVAGRGDAAVDDLIGFFVNTLVLRTDLGGDPSFAELLGRVREMNLAAYAHQ 1374 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 ++P ERLVE L P R+LSR+PLFQ ML F+ Sbjct: 1375 DVPFERLVEELQPARSLSRHPLFQVMLTFQ 1404 Score = 556 bits (1432), Expect = e-155 Identities = 422/1117 (37%), Positives = 553/1117 (49%), Gaps = 95/1117 (8%) Query: 33 QPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARH 92 +P + P LS GQ RMWFL N+ A RL G +D L A+ DV RH Sbjct: 3161 RPAVVP-----LSYGQTRMWFLNRFQEGGAVYNMPFALRLTGELDVAALRAALGDVALRH 3215 Query: 93 AILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTN 152 LRT + DT G P Q + V L+ + A + + L E GR FD+ Sbjct: 3216 ESLRTVFP-DTGGVPRQEVREGSPV------LSVVEVAAED--VPLLLRAEVGRGFDVGR 3266 Query: 153 ELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPIN 201 ELP R+++ A E VL++VVHHI D S V +LSAAY LP+ Sbjct: 3267 ELPWRVSLFVVSAREHVLVVVVHHIAADGWSMGVLGRDLSAAYAARLSGRAPSWVGLPVQ 3326 Query: 202 DPAAQFLSVEVLQNSAAPSV---ADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRR--- 255 VL + + P A +GYW L V P + R Sbjct: 3327 YADYALWQRAVLGSESDPGSLLSAQLGYWRSALAGLPVELVLP-VDRPRPAVASYRGGAV 3385 Query: 256 -VRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 VR + AG+ R+ + AR A+ FMV+ AA VL+ R D V V R AA Sbjct: 3386 PVR-VGAGVHGRLVEVARAGQATLFMVVQAAVAVLLSRLGAGVDIPVGTAVAGRGAAALD 3444 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 L G+F NTL+LR+ +F V VRE LA +AHQ V +R+V E P R Sbjct: 3445 DLVGFFVNTLVLRVGLGGDPSFAEVVGRVREVDLAAYAHQDVPFERLVEEVQPVRSLARH 3504 Query: 374 MDLLVRLGFNMRKSAGGLALDGVVVRQL---GLGAVAAHLPLSLTIALDPDDVSVEFEYQ 430 V L F G L G+ V Q+ G GA L L+LT D + + Sbjct: 3505 PLFQVMLTFQNAPRTSGWELPGLQVSQVRAGGGGAAKFDLSLALTEHRDAEGGAAGLAGV 3564 Query: 431 QQLSSVLVDQ-----MLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM 485 + S+ L D+ ++ ++L++ A+P LS +D+L GE D V+ +G V Sbjct: 3565 LEYSADLFDRSTAEGLVGRLVRLLEVVGADPGLRLSQVDVLADGEYDLVVRAWNGSAVGG 3624 Query: 486 PA--------TTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGF 537 A + V ++ LTY+EL NRLAR +G G Sbjct: 3625 SAVGGSAVGVSARTLPEMFQAQVVARPDAVAVVCEDVRLTYAELDAAVNRLARLLVGLGV 3684 Query: 538 GPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR--- 594 GPE I+ + + S+E +VA+LAVLKAGAAYLP+DP YP R +++ DA P +G Sbjct: 3685 GPERIVAVALPRSVEMVVALLAVLKAGAAYLPVDPEYPAARQAFMLADAAPVVTLGTART 3744 Query: 595 ----PELDVAERAAADNSD-------LP---LSDSDRLRPLRPGHLAYVIYTSGSTGRPK 640 PE A R D D LP + D++R+R LRPGH AYVIYTSGSTG PK Sbjct: 3745 VGALPEHG-AVRVVVDAPDTVRVLAGLPGTAVRDAERVRSLRPGHPAYVIYTSGSTGTPK 3803 Query: 641 GVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDA 700 GV + +A ++ + + A+D W F S +FD S+ ++F L LG +++V Sbjct: 3804 GVLIPQRNVAALIETAGRVYGLGADDVWSLFHSYAFDFSVWEMFGALLLGGRVVVVAHSV 3863 Query: 701 FGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQ-WRQLRHVPVGGEAL-PGEVA-- 756 +L+SR GVTV LR+V GGEAL P + Sbjct: 3864 SRSPREFVELLSRTGVTVLSQTPSAFYQVIGELAAAGVGSSLRYVVFGGEALEPARLRQW 3923 Query: 757 -DRFAGYFDAELRNHYGPTEAVVCSTHM------VVTGSHGARVVPIGVPNRNVYAYVLD 809 DR+ G L N YG TE V TH+ VV G+ +G P V YVLD Sbjct: 3924 YDRYPGDVPV-LVNMYGITETTVHVTHIALDRERVVAGTGSV----VGGPLPGVRTYVLD 3978 Query: 810 EQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHC 868 E L PVP V+GELY+ G+ LARGYL RP LT +RF+A PF G R+YRTGDL R Sbjct: 3979 EFLRPVPPGVVGELYVAGAGLARGYLNRPALTGERFVACPFGGSGERMYRTGDLARWTGD 4038 Query: 869 GELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAA 927 G L F GRAD QVKIRGFRIE GE+E+V++ HPAV VV E + G L AYLVP Sbjct: 4039 GGLVFAGRADAQVKIRGFRIEPGEIEAVLSGHPAVDQVAVVMREDQPGHRHLVAYLVPHQ 4098 Query: 928 AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPET 987 ++ EIRA A +PEYMVP + E+P+T +GKLDR ALPAP A R P T Sbjct: 4099 -EIGAAEIRAFVAGRLPEYMVPAVVVEVAELPLTANGKLDRAALPAPDFGALATGRGPRT 4157 Query: 988 ATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPT 1047 A E +C++FA++ RVGA+D FF LGG SLLA RL+A+IR G +L VRT+F PT Sbjct: 4158 AVEERLCALFAEVLDLARVGADDGFFDLGGDSLLAMRLIARIREVLGTELNVRTLFAEPT 4217 Query: 1048 PAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 PAG+AA L R +D D D L +P+ + RP Sbjct: 4218 PAGVAASLETRGEDD---DFDVL----LPIRTEGTRP 4247 Score = 40.0 bits (92), Expect = 2.9 Identities = 22/67 (32%), Positives = 39/67 (58%), Gaps = 1/67 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMTIA 1618 E RL A+ E+L++ + D+ +F LGGDS++A++ A+ LG +F T A Sbjct: 4160 EERLCALFAEVLDLARVGADDGFFDLGGDSLLAMRLIARIREVLGTELNVRTLFAEPTPA 4219 Query: 1619 ELAAAVD 1625 +AA+++ Sbjct: 4220 GVAASLE 4226 >tr|D1A2F2|D1A2F2_THECU Tax_Id=471852 SubName: Full=Amino acid adenylation domain protein;[Thermomonospora curvata DSM 43183] Length = 4090 Score = 788 bits (2034), Expect = 0.0 Identities = 527/1444 (36%), Positives = 724/1444 (50%), Gaps = 90/1444 (6%) Query: 20 IAESGLAAEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 +AE G+ + S P G LS Q+ MW PD N+C+ R++G +D Sbjct: 5 MAERGIGRDTSRIAPRTSDGPA-PLSYAQQSMWLHHRAFPDSPAYNVCLLVRMSGDLDIS 63 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 LH A+ VV RHAILRTTY + P Q DD + DL G E+ Sbjct: 64 ALHAALRGVVRRHAILRTTY----DDGPVQHIHDDDSL-----DLPVRDYPGTGADAEAW 114 Query: 140 AADEFGR----PFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY 195 A + GR PFDL E P+R+ ++R E L++V+HHI D W GEL+A Y Sbjct: 115 ARAQAGRIAARPFDLRTERPIRVELLRLAPREHGLVVVIHHIACDGTVWGTMSGELAALY 174 Query: 196 NDLPINDPAA------QFLSVEVLQNSAAPSVADVGYWAETL--RXXXXXXXXXGVSGAN 247 +P Q+ + S D+ YW L A Sbjct: 175 RAALTGEPDGLAPLPIQYADYAAWEQRRPLSREDLEYWRRRLDPAPEPLDLPTDRPRTAT 234 Query: 248 PCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTE 307 RVR + + + D A + +A+PFMV+LA Y L+ RYTGA+D V V Sbjct: 235 VSETGGHRVRRFDDAVTAGIRDLAARENATPFMVMLAGYAALLHRYTGATDIPVGSLVQS 294 Query: 308 RSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANP 366 R A L G+FGNTL+LR TF + VR+ C FAHQ++ D++V E P Sbjct: 295 REHAETQPLIGHFGNTLVLRTDLSGNPTFRELLARVRQNCTEDFAHQALPYDKIVEELRP 354 Query: 367 ERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE 426 R R + + G L L G+ + + A H LSL + VE Sbjct: 355 ARP-RGRSPYFDTMFMYLAHEIGELDLPGITSWWTHIPSGAVHFDLSLEAFARSHGLEVE 413 Query: 427 FEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM 485 ++++L +D +L H L+ A+ +P R ++ L++L ER LA+ + + Sbjct: 414 ATFRRELFDDERIDALLAHLETLLRSAVTDPGRRITDLELLSESERRQ-LAEWNATDRPV 472 Query: 486 PATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGL 545 PATT+V+ S+ LTY+EL RRA+ LA +G GP ++ L Sbjct: 473 PATTVVELFEQQAARTPDAIAVE--SETGTLTYAELDRRASGLAALLRARGAGPGKVVAL 530 Query: 546 RMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL------DV 599 + + + + A+LAVLK+GAAYLP+D +P +R+ Y++ DA P + + D Sbjct: 531 ALPRTGDLVAAVLAVLKSGAAYLPLDLDHPADRLAYMLQDAAPLCTLATEQTRAVLPDDA 590 Query: 600 AERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAE 659 D + P RP+ LAYVIYTSGSTGRPKGVAV H A+ + E Sbjct: 591 EVLVLGDRTPAPAPS----RPVTGDDLAYVIYTSGSTGRPKGVAVPHAALTNFLLMQREE 646 Query: 660 WTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVX 719 + DR + ++++FD + +++V L GA +++ +A D + +A+L++ + Sbjct: 647 LALRPGDRLVAVTTIAFDIAALELYVPLISGATVVLASRNAVRDPAALAELLADATIVQA 706 Query: 720 XXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVC 779 Q V VGGEALP +AD + N YGPTEA + Sbjct: 707 TPSLLGSLDPAAL-------QGLRVLVGGEALPAALADTLTRVA-SRATNVYGPTEATIW 758 Query: 780 STHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPT 839 +T + + IG P N AYVLD L PVP V GELYL G+QLA GY+GRP Sbjct: 759 ATSAELPSTG------IGRPFWNTRAYVLDASLRPVPPGVPGELYLAGAQLAHGYIGRPD 812 Query: 840 LTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVIT 898 LTA+RF+ADPF P G R+YRTGDL R G LE++GR D+QVKIRGFRIE GEV++V+ Sbjct: 813 LTAERFVADPFGPPGTRMYRTGDLARWRRDGTLEYLGRTDDQVKIRGFRIEPGEVQAVLA 872 Query: 899 THPAVRHCLVVAEETEAGPM-LAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPE 957 P V V+ E G L YLVP +D +RA A A+PEYM+P A V+ Sbjct: 873 AQPGVAQAAVIVREDRPGDKRLVGYLVPGPEGLDETAVRAAAARALPEYMLPSALVVLDA 932 Query: 958 IPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGG 1017 +P TV+GKLDRRALPAP R P A E +C +FA+ G VG +D FF LGG Sbjct: 933 LPRTVNGKLDRRALPAPH--LETGGRRPRDARETALCELFAEALGVDEVGIDDDFFALGG 990 Query: 1018 HSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPL 1077 HSLLAARL +IRA G +LT+ +F+APT A LA RLVE R Sbjct: 991 HSLLAARLAGRIRAALGAELTIADVFEAPTVAQLAPRLVEGTRT---------------- 1034 Query: 1078 DPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXX 1137 R R RP+ +P S +Q W + R+ G + +PL R GP Sbjct: 1035 ---RVRD----VTRPEVVPASAAQRGLWLEERMHGPSVSYTVPLGARLRGPLDVAALRAA 1087 Query: 1138 XXXXXXRHEALRTNFDEH-EGVPYQIVHPSRTVQLAVR---AIDQDEFDDVSTQLRRHVF 1193 RHEALRT E +G+P Q V P VR + D+ + Q RH F Sbjct: 1088 FGDVVARHEALRTLLVEGPDGLPIQRVLPPGGELFEVRDLRGLPADQVAEAEAQAARHRF 1147 Query: 1194 TPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDI 1253 ++A LL + + L+L+ HH +D S + DL AY AR Q P W Sbjct: 1148 RLGVDLPIRATLLRVDDEAWTLILLQHHAAADEWSFTPLLADLSRAYAARAQGREPDWAP 1207 Query: 1254 LPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQF 1313 LP+Q+ADY VW ++ +LD+W ALAGLP+E ++ DR RP G RG+ V F Sbjct: 1208 LPVQYADYTVWDAAQDHTH----QLDHWERALAGLPEETTLPPDRPRPAEAGHRGDQVTF 1263 Query: 1314 SVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLV 1373 +P + +LA G + FM+ AA+A VL + G G DIALG+P+AAR + A LV Sbjct: 1264 QLPLD---GVRELARSTGTSVFMVLHAAMAAVLQRAGAGDDIALGTPIAARPDEDLADLV 1320 Query: 1374 GLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLF 1433 G+F N++VLRTDLSGDPT +L R LDA AH ++P E++VE L P R+L+R+PLF Sbjct: 1321 GVFVNLLVLRTDLSGDPTFTELLQRVRTADLDAFAHADVPFEQVVERLAPERSLARSPLF 1380 Query: 1434 QNML 1437 Q M+ Sbjct: 1381 QVMI 1384 Score = 394 bits (1012), Expect = e-107 Identities = 335/1042 (32%), Positives = 452/1042 (43%), Gaps = 100/1042 (9%) Query: 45 SDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTE 104 S QR +W + M V+ + + RL G +D L A DVVARH LRT + Sbjct: 1048 SAAQRGLWLEERMHGPSVSYTVPLGARLRGPLDVAALRAAFGDVVARHEALRTLLVEGPD 1107 Query: 105 GEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTR 164 G P Q + DL LP Q+ A F L +LP+R T++R Sbjct: 1108 GLPIQRVLPPGGELFEVRDLRGLPAD----QVAEAEAQAARHRFRLGVDLPIRATLLRVD 1163 Query: 165 ADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADV 224 + L+L+ HH D+ S+ +LS AY AA+ E AD Sbjct: 1164 DEAWTLILLQHHAAADEWSFTPLLADLSRAY--------AARAQGREPDWAPLPVQYADY 1215 Query: 225 GYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSR------------VEDFAR 272 W P RP PA R V + AR Sbjct: 1216 TVWDAAQDHTHQLDHWERALAGLPEETTLPPDRPRPAEAGHRGDQVTFQLPLDGVRELAR 1275 Query: 273 KCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA-AAGALGYFGNTLLLRITTRS 331 S FMVL AA +++R D + P+ R A +G F N L+LR Sbjct: 1276 STGTSVFMVLHAAMAAVLQRAGAGDDIALGTPIAARPDEDLADLVGVFVNLLVLRTDLSG 1335 Query: 332 QDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFNMRKSAGG 390 TFT + VR L FAH V ++VV PER + R + ++ + + R + Sbjct: 1336 DPTFTELLQRVRTADLDAFAHADVPFEQVVERLAPERSLARSPLFQVMIV--HQRLADAR 1393 Query: 391 LALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQLV 449 L L GV L + A D + Y L V + L+ Sbjct: 1394 LKLPGVEAEPFLPKTGGVKFDLDVYFAEGDDRIEGVAAYATDLYDRETVTALFDRLAALL 1453 Query: 450 DKALAEPERPLSSL-----------DILGAGERDSVLAQSHGELVEMPATTMVKXXXXXX 498 +A+ P R LS L D G D + A+ + PA + Sbjct: 1454 TRAVRHPGRRLSQLLPPFDHPDTARDFGGRTVAD-LFAEQAARTPDAPALILPGGSGQAA 1512 Query: 499 XXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAML 558 D ++Y+EL RRA LA G GPE ++ + + S EF+ A+L Sbjct: 1513 ATAENDPAGRSPQDVV-ISYAELDRRAEELADRLAAAGAGPEQVVAIALPRSAEFVTALL 1571 Query: 559 AVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR--PELDVAERAAADNSDLPLSDSD 616 AV+K GAAYLPID YP RID+++ ARP V+GR P D R + Sbjct: 1572 AVIKTGAAYLPIDVTYPQARIDHMLQAARPLLVLGRDEPPADAPPRERVE---------- 1621 Query: 617 RLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQF--SSV 674 + P H AYVI+TSGSTG PK V + A+A + W + + ++ SS Sbjct: 1622 ----ILPDHPAYVIFTSGSTGTPKAVVGTQRALANRL-----AWGLDLVEPGMRVAKSSP 1672 Query: 675 SFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISR---RGVTVXXXXXXXXXXXXX 731 +F ++ L G +++ D +A+LI R R VTV Sbjct: 1673 AFIDGTTELLGGLLAGDPVLIADDATATDPVALAELIDRYRARTVTVVPSLLAALLEAGD 1732 Query: 732 XXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGA 791 W GEALP +ADR A L N YG +EA ++ G+ A Sbjct: 1733 LGSVTTWIS------SGEALPAGLADRIG----ARLINLYGCSEA--AGDSLIAEGT--A 1778 Query: 792 RVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN 851 + PI N AYVLD+ L V +GELYL G LARGYL P TA+RF+A+PF Sbjct: 1779 TLHPIA----NTTAYVLDDALREVE---VGELYLAGDGLARGYLNDPARTAERFVANPFG 1831 Query: 852 -PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA 910 PG RLYRTGD VRR G LEF+GRAD+Q+KIRGFRIE GE+E+V+ P VR V A Sbjct: 1832 PPGSRLYRTGDRVRRRRDGGLEFLGRADDQIKIRGFRIEPGEIEAVLAAQPGVRRAAVTA 1891 Query: 911 EETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRA 970 L YLV D + +P+Y+VP V+ E+P+ +GK+DRRA Sbjct: 1892 HSGR----LVGYLV---GDADTSALHDRLRELLPDYLVPSDLVVLDELPLNPNGKIDRRA 1944 Query: 971 LPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIR 1030 LP P T R R P T ER + ++ +L GR +GA+D FF +GG S+ AA LVA+ R Sbjct: 1945 LPEPG--RTGRGRAPRTEAERTLAALVTELLGRDGIGADDDFFRIGGDSISAALLVARAR 2002 Query: 1031 AEFGVDLTVRTIFDAPTPAGLA 1052 G+ TVR +F T A LA Sbjct: 2003 -RTGLTFTVRDVFRLRTIAALA 2023 Score = 335 bits (859), Expect = 3e-89 Identities = 207/576 (35%), Positives = 293/576 (50%), Gaps = 43/576 (7%) Query: 935 IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRY--REPETATERW 992 +R A +P YMVP + +P+TV+GKLDRRALP P + R R P T ER Sbjct: 3424 VREGLKAKLPGYMVPSVIMTLDALPLTVNGKLDRRALPTPDAGSGPRGTGRPPRTPVERL 3483 Query: 993 ICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA 1052 +CS+FA++ + VG +D+FF LGGHSLLA RL+ + R +L +R +F+APT A LA Sbjct: 3484 LCSLFAEVLQVKEVGIDDNFFDLGGHSLLATRLIGRARTVLRGELAIRDLFEAPTVAELA 3543 Query: 1053 ARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRI-- 1110 R+ R D RP RP+ +PLS +Q W ++ Sbjct: 3544 ERIHSR------------------ADATEERPALTPRPRPEHIPLSFAQHRLWLLDQLLR 3585 Query: 1111 --EGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRT 1168 +G R +++PL + G RHE LRT F +H+G PYQ + P Sbjct: 3586 EDDGPRSAYHLPLGVYLRGELDLEALEAAIWDVIARHETLRTVFADHDGTPYQRILPPDQ 3645 Query: 1169 VQ--LAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDH 1226 + L + EF + L R + L+A G H+LL + HHI D Sbjct: 3646 ARPPLEIDPCTPQEFIERPFDLARDI-------PLRAAAFRTGDREHLLLAVFHHIAFDE 3698 Query: 1227 ASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYW 1281 S +++ AY AR Q AP W+ +Q+ADY +WQR + +L YW Sbjct: 3699 GSFGPFSREVVEAYTARRQGKAPDWEPPAVQYADYTLWQRELLGDPLDPGSLHARQLAYW 3758 Query: 1282 RDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAA 1341 AL+G+P+EI + DR RP +G+RG V +P + A+ +LA GAT FM+ QAA Sbjct: 3759 AQALSGIPEEIPLPVDRPRPGTVGQRGGTVIRDLPPSLVKAVRRLAREGGATVFMVGQAA 3818 Query: 1342 LAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRD 1401 +A +LH++G G DI LGSPVA R + A LVG F N +VLR D SG+PT +L R+ Sbjct: 3819 VAALLHRMGAGDDIPLGSPVAGRTDEALGNLVGFFVNTLVLRADCSGNPTFAELLSRIRE 3878 Query: 1402 TVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVP 1461 L LA+Q+LP E LVEAL P R RNPLFQ M+ + + + V + V P Sbjct: 3879 ADLAGLANQDLPFEALVEALRPRRVPGRNPLFQVMVGYENQAGSEVRFPDLEQRNALVGP 3938 Query: 1462 LPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 F++ +F P+G L + + +ADL++ Sbjct: 3939 SAAKFDLDFIF-----REEPNGGLRLVLDYSADLFD 3969 Score = 276 bits (705), Expect = 2e-71 Identities = 258/918 (28%), Positives = 389/918 (42%), Gaps = 82/918 (8%) Query: 72 LAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAG 131 L+G + +R+ A V+ + LR + D Q + +V W ++ R PE Sbjct: 2176 LSGPLQPERMADAARRVLEKFPNLRAGFRTDG-ARTVQFIPEHFDVPWTYAEV-RTPE-- 2231 Query: 132 HERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGEL 191 ++E+ ++ RPF +R + R + L+L I D S + G L Sbjct: 2232 ---ELEAFIEEQRARPFTPDRPPLIRFGLARVGEGDYRLVLTSELILLDGWSGGLLIGSL 2288 Query: 192 SAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRR 251 Y D PAA+ P A + + R +SG + Sbjct: 2289 MEFYTD-----PAAEHA------RPVTPFTAYLDWVGGRDRQAALEAWRHALSGFDTPAL 2337 Query: 252 AQRRV--------------RPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGAS 297 + + RPLP GL R+E AR + V A+G+L+ TG Sbjct: 2338 LKPELLDRPADLADAGEIHRPLPPGLIDRLEALARDRGITLGTVYQTAWGLLLMALTGRD 2397 Query: 298 DFLVSVPVTERSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQS 354 D + V V+ R G +G NT+ +R+ D + + V+ F H Sbjct: 2398 DVVFGVSVSGRHPEVDGVESIVGLLFNTVPVRVQAGPADPLATVLERVQNAHADLFDHFH 2457 Query: 355 VGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSL 414 V + + + M G ++ G +V RQ+ A H P + Sbjct: 2458 VTLTDIQQATGLGTMFDTLFVFQNFPGIPTDRAFGPGRDVRLVERQV---RDATHYP--I 2512 Query: 415 TIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSV 474 T+ +PD + V ++ Y+Q++ P+ P LD L E + + Sbjct: 2513 TMVAEPDAHLRVMYRGDAFTEPEVHRLTDRYVQILQAIAENPDTPCHRLDALLPDEHEQI 2572 Query: 475 LAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSD-EAELTYSELHRRANRLARWFI 533 ++ E E P + VS + LTY+EL NRLAR Sbjct: 2573 -RRTWAE-AEHPVPDLTIAELLAERARQIPDEIALVSQPDVRLTYAELIGEVNRLARLLK 2630 Query: 534 GQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG 593 G GPE ++ L + S + ++A+ AVL+ GAAYLP++ YP ER++Y+I DA P ++ Sbjct: 2631 QHGAGPEKVVALALPRSAQMVIALFAVLRTGAAYLPLELDYPAERLNYMIADAGPSCLVS 2690 Query: 594 RPEL--------------------DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTS 633 ++ +A D +D L R P R H AYVIYTS Sbjct: 2691 HRDIAAGLDYDGPAILLDDPHTRNRLAALPGTDLTDEELPGFTRTTPGRLEHPAYVIYTS 2750 Query: 634 GSTGRPKGVAVSHHAIAE---HVQGFVAEWTMTAEDRWLQFS---SVSFDASLADIFVTL 687 GSTGRPKGV + + + + + + ++A R L+ + S SFD S ++ + L Sbjct: 2751 GSTGRPKGVITPYRGLTNMQYNHRANIFDPVVSAAGRRLKIAHTVSFSFDMSWEEL-LWL 2809 Query: 688 FLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVG 747 G ++ V D D + + + V + V +G Sbjct: 2810 IEGHEVHVCDEDLRRDAEALTAYLQEHKIDVINVTPTYAQQLLEEGLLDGAHRPPLVLLG 2869 Query: 748 GEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYV 807 GEA+P V +R A N YGPTE + + + G+ + +G P N YV Sbjct: 2870 GEAVPVAVWERLAQADGVLGYNLYGPTEYTI---NTLGGGTEDSATPTVGKPIWNTRGYV 2926 Query: 808 LDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRN 866 LD L PVP GELY+ G+ LARGYLGRP LTA+RF+ADPF PG R+YRTGDLVR Sbjct: 2927 LDPWLRPVPPGTPGELYIAGAGLARGYLGRPDLTAERFVADPFGPPGGRMYRTGDLVRVR 2986 Query: 867 HCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM--LAAYLV 924 G ++F+GR D+QVKIRG+R+EL EVE+ + P V VV +T+ + L Y+V Sbjct: 2987 EDGNIDFLGRTDDQVKIRGYRVELEEVEAALAAEPGVGQAAVVTADTDVPGVKRLIGYIV 3046 Query: 925 ------PAAAQVDLEEIR 936 P AA+ L E R Sbjct: 3047 PDGQARPGAAEEQLTEWR 3064 Score = 174 bits (442), Expect = 7e-41 Identities = 113/350 (32%), Positives = 165/350 (47%), Gaps = 12/350 (3%) Query: 1096 PLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEH 1155 PLS++Q + W +R +N+ L +R G RH LRT +D+ Sbjct: 27 PLSYAQQSMWLHHRAFPDSPAYNVCLLVRMSGDLDISALHAALRGVVRRHAILRTTYDDG 86 Query: 1156 EGVPYQIVHPSRTVQLAVR-----AIDQDEFDDVST-QLRRHVFTPESGPLLQANLLVLG 1209 P Q +H ++ L VR D + + ++ F + ++ LL L Sbjct: 87 ---PVQHIHDDDSLDLPVRDYPGTGADAEAWARAQAGRIAARPFDLRTERPIRVELLRLA 143 Query: 1210 PDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF 1269 P H L++++HHI D + +L YRA L LPIQ+ADYA W++ Sbjct: 144 PREHGLVVVIHHIACDGTVWGTMSGELAALYRAALTGEPDGLAPLPIQYADYAAWEQRRP 203 Query: 1270 ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAER 1329 S + +L+YWR L P+ + + TDR R + + G A A + LA R Sbjct: 204 LS---REDLEYWRRRLDPAPEPLDLPTDRPRTATVSETGGHRVRRFDDAVTAGIRDLAAR 260 Query: 1330 NGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGD 1389 AT FM+ A A +LH+ G TDI +GS V +R T L+G F N +VLRTDLSG+ Sbjct: 261 ENATPFMVMLAGYAALLHRYTGATDIPVGSLVQSREHAETQPLIGHFGNTLVLRTDLSGN 320 Query: 1390 PTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 PT R +L R + AHQ LP +++VE L P R R+P F M + Sbjct: 321 PTFRELLARVRQNCTEDFAHQALPYDKIVEELRPARPRGRSPYFDTMFMY 370 Score = 139 bits (349), Expect = 5e-30 Identities = 134/465 (28%), Positives = 194/465 (41%), Gaps = 44/465 (9%) Query: 27 AEQSSDQPGICPG---ERYRLSDGQRRMWFL-QTMDPDD---VTLNICVAYRLAGLVDED 79 A+ + ++P + P E LS Q R+W L Q + DD ++ + L G +D + Sbjct: 3550 ADATEERPALTPRPRPEHIPLSFAQHRLWLLDQLLREDDGPRSAYHLPLGVYLRGELDLE 3609 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESL 139 L A+ DV+ARH LRT + D +G PYQ D R P +I+ Sbjct: 3610 ALEAAIWDVIARHETLRTVFA-DHDGTPYQRILPP--------DQARPP-----LEIDPC 3655 Query: 140 AADEF-GRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDL 198 EF RPFDL ++PLR RT E +LL V HHI +D+ S+ F E+ AY Sbjct: 3656 TPQEFIERPFDLARDIPLRAAAFRTGDREHLLLAVFHHIAFDEGSFGPFSREVVEAYTAR 3715 Query: 199 ------PINDPAAQFLSVEVLQNSAAPSVADVG--------YWAETLRXXXXXXXXXGVS 244 PA Q+ + Q D G YWA+ L V Sbjct: 3716 RQGKAPDWEPPAVQYADYTLWQRELLGDPLDPGSLHARQLAYWAQALSGIPEEIPLP-VD 3774 Query: 245 GANPCRRAQRR---VRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLV 301 P QR +R LP L V AR+ A+ FMV AA L+ R D + Sbjct: 3775 RPRPGTVGQRGGTVIRDLPPSLVKAVRRLAREGGATVFMVGQAAVAALLHRMGAGDDIPL 3834 Query: 302 SVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV 360 PV R+ A G L G+F NTL+LR TF ++ +RE LAG A+Q + + + Sbjct: 3835 GSPVAGRTDEALGNLVGFFVNTLVLRADCSGNPTFAELLSRIREADLAGLANQDLPFEAL 3894 Query: 361 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDP 420 V P R+ V +G+ ++ + + R +G AA L +P Sbjct: 3895 VEALRPRRVPGRNPLFQVMVGYE-NQAGSEVRFPDLEQRNALVGPSAAKFDLDFIFREEP 3953 Query: 421 D-DVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSL 463 + + + +Y L D M L L++K + PLS+L Sbjct: 3954 NGGLRLVLDYSADLFDESTADTMASGLLDLLEKVTTDSTIPLSAL 3998 Score = 63.2 bits (152), Expect = 3e-07 Identities = 39/103 (37%), Positives = 55/103 (53%), Gaps = 7/103 (6%) Query: 960 MTVSGKLDRRALPAPTPIATRRYREPETATERW------ICSIFAQLFGRQRVGAEDSFF 1013 +T + ALP+P T + +T T+ C IFA++ G VG +D FF Sbjct: 3987 VTTDSTIPLSALPSPLTARTVTGPDRQTTTDHHDDRQATFCRIFAEVLGVDAVGPDDDFF 4046 Query: 1014 GLGGHSLLAARLVAQIRAEFGVD-LTVRTIFDAPTPAGLAARL 1055 LGGHSLLA +LV ++R E G + L V T+ AP+ L +RL Sbjct: 4047 DLGGHSLLAMKLVRRLRQEPGCEHLKVATLMTAPSVNALLSRL 4089 Score = 62.0 bits (149), Expect = 7e-07 Identities = 39/95 (41%), Positives = 46/95 (48%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 E ER L A++ ELL GI D+++F +GGDSI A A+A GL F VF TI Sbjct: 1960 EAERTLAALVTELLGRDGIGADDDFFRIGGDSISAALLVARARRTGLTFTVRDVFRLRTI 2019 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLA 1652 A LA A P A P P T A G A Sbjct: 2020 AALAEAAQPVETAPSTGAQPEPGTAATSAGADGAA 2054 Score = 54.3 bits (129), Expect = 1e-04 Identities = 64/261 (24%), Positives = 102/261 (39%), Gaps = 14/261 (5%) Query: 1179 DEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIV 1238 +E + + R FTP+ PL++ L +G + L+L I+ D S ++ L+ Sbjct: 2231 EELEAFIEEQRARPFTPDRPPLIRFGLARVGEGDYRLVLTSELILLDGWSGGLLIGSLME 2290 Query: 1239 AYR-ARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATD 1297 Y +H P + P F Y W Q L+ WR AL+G + + Sbjct: 2291 FYTDPAAEHARP---VTP--FTAYLDWVGGRDR----QAALEAWRHALSGFDTPALLKPE 2341 Query: 1298 RA-RPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIA 1356 RP L GE+ + +P L LA G T +YQ A ++L L G D+ Sbjct: 2342 LLDRPADLADAGEIHR-PLPPGLIDRLEALARDRGITLGTVYQTAWGLLLMALTGRDDVV 2400 Query: 1357 LGSPVAAR--VEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPI 1414 G V+ R +VGL N V +R L ++L ++ D H + + Sbjct: 2401 FGVSVSGRHPEVDGVESIVGLLFNTVPVRVQAGPADPLATVLERVQNAHADLFDHFHVTL 2460 Query: 1415 ERLVEALNPPRALSRNPLFQN 1435 + +A +FQN Sbjct: 2461 TDIQQATGLGTMFDTLFVFQN 2481 Score = 43.1 bits (100), Expect = 0.34 Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 15/97 (15%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQA-----GALGLPFPPAMVFEH 1614 ER L ++ E+L++ + D+N+F LGG S++A + +A G L + +FE Sbjct: 3481 ERLLCSLFAEVLQVKEVGIDDNFFDLGGHSLLATRLIGRARTVLRGELAI----RDLFEA 3536 Query: 1615 MTIAELAAAV----DAANGEPVVEADPPPAQEYTPMS 1647 T+AELA + DA P + P P E+ P+S Sbjct: 3537 PTVAELAERIHSRADATEERPAL--TPRPRPEHIPLS 3571 Score = 42.7 bits (99), Expect = 0.44 Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 7/94 (7%) Query: 1560 ERRLTAMLEELLEITGIDR---DENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHM 1615 + R TA+ E E G+D D+++FALGG S++A + + + ALG A VFE Sbjct: 960 DARETALCELFAEALGVDEVGIDDDFFALGGHSLLAARLAGRIRAALGAELTIADVFEAP 1019 Query: 1616 TIAELAAAVDAANGEPVVEADPPPAQEYTPMSAS 1649 T+A+LA + V + P E P SA+ Sbjct: 1020 TVAQLAPRLVEGTRTRVRDVTRP---EVVPASAA 1050 >tr|Q45R85|Q45R85_STRFR Tax_Id=1906 (lptA)SubName: Full=Peptide synthetase;[Streptomyces fradiae] Length = 6292 Score = 787 bits (2033), Expect = 0.0 Identities = 548/1470 (37%), Positives = 725/1470 (49%), Gaps = 100/1470 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS QRR+WFL D + +I VA RL G +D D LH A+ D+ ARH LRT + Sbjct: 3715 ERLPLSPAQRRLWFLNRYDREAGGYHISVALRLTGDLDVDALHAALGDLTARHESLRTVF 3774 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 D +G P+QV D +P A H +I++L + RPFDL +++PLR T Sbjct: 3775 REDEQG-PHQVVLDP----GAPPAPAVVPAAAH--RIDALVREAVRRPFDLADDIPLRHT 3827 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN--------DLPINDPAAQFLSVE 211 + E VLLLV+HHI D S +L+AAY D P PAA+ + Sbjct: 3828 LFTLPDGEHVLLLVIHHIAADGWSMGPLARDLAAAYRARAAGRAPDWPA--PAARPAAHP 3885 Query: 212 VLQNSA-APSVAD--VGYWAETLRXXXXXXXXX--GVSGANPCRRAQRRVRPLPAGLFSR 266 Q+ D + +WAE LR P A+R + A L+ Sbjct: 3886 PGQHGDDVDDTVDRRLAHWAEELRGLPDELALPYDRPRPTTPPGYAERVPFRVDAALYRD 3945 Query: 267 VEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA-AAGALGYFGNTLLL 325 V A + A+PFMVL AA L R D V P R A +G+ NTL+L Sbjct: 3946 VRALAARHRATPFMVLHAALAALWHRLGAGPDIPVGTPSAGRDRPETADLVGFLVNTLVL 4005 Query: 326 RITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMR 385 R T F ++ VRET L +AHQ V +R+V NP R LV+ Sbjct: 4006 RTDTSGDPAFAELLDRVRETDLRAYAHQDVPFERLVEAVNPARS--PSRHPLVQTMLTFD 4063 Query: 386 KSAGG-----LALDGVVVRQLGLGAVAAHLPLSLTIA-----LDPDDVSVEFEYQQQLSS 435 +A G L L GV L AH + LT D D + Y+ L Sbjct: 4064 NAAHGALDHLLDLPGVRAELLPTAEGTAHTDIELTFTETTADTDGDGLDASLRYRPDLFD 4123 Query: 436 VLVDQMLVH-YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 + L ++ L+ EP L LD+ AGER + AT + Sbjct: 4124 RTTARALAERFMALLRTVTREPALRLGQLDVTTAGERRRLADADAAARARTAATAVAVLP 4183 Query: 495 XXXXXXXXXXXXXXXVSD-EAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEF 553 ++D A L Y+EL R+NRLAR +G G GPED + L + S + Sbjct: 4184 ALFAASAHRTPAAPALTDGPATLDYAELDARSNRLARALLGLGVGPEDFVALAVPRSADL 4243 Query: 554 IVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL------DVAER----- 602 +VA+LAVLK+GAAYL +DP +P ER Y++ D RP V+ + V E Sbjct: 4244 VVAVLAVLKSGAAYLAVDPDHPAERTSYILHDCRPVAVLSTTAVRETLHGTVGEAVGEVP 4303 Query: 603 -----------AAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAE 651 A A +S P++D+DR PL P H AY IYTSGSTGRPKGV VSH ++ Sbjct: 4304 WLLLDEPATGGATAGHSAAPVTDADRRSPLLPDHPAYTIYTSGSTGRPKGVVVSHANVSR 4363 Query: 652 HVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLI 711 + A +D W F S +FD S+ +++ L G +L+V D + DL+ Sbjct: 4364 LLTACRAAVDFGPDDVWTLFHSSAFDFSVWEMWGPLAHGGRLVVVPHDVARSPGDLLDLL 4423 Query: 712 SRRGVTVXXXXXXXXXXXXXXXXXX-----QWRQLRHVPVGGEALPGEVADRFAGYFDAE 766 R VTV LR+V GGEAL + G Sbjct: 4424 GRERVTVLSQTPSAFLQLLRAESDLGVPPRTTAALRYVVFGGEALDTAQLAPWRGR-PVR 4482 Query: 767 LRNHYGPTEAVVCSTHMVVTGSHGARV-VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYL 825 L N YG TE V TH+ + + R PIG P ++ A+VLD+ L PVP V+GELY+ Sbjct: 4483 LVNMYGITETTVHVTHLELDDAAVDRGGSPIGTPLNDLRAHVLDQGLLPVPVGVVGELYV 4542 Query: 826 GGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRG 885 G LARGY RP L+A RF+ADPF+ G R+YRTGDLVRR G L +VGR+D QVK+RG Sbjct: 4543 AGPGLARGYRRRPGLSATRFVADPFDTGGRMYRTGDLVRRTQDGGLHYVGRSDSQVKLRG 4602 Query: 886 FRIELGEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVPAA-AQVDLEEIRAHTAAAV 943 +RIE GE+E+ HP V E L Y+VPAA D ++RAH A A+ Sbjct: 4603 YRIEPGEIEAAARRHPDVAQAATAVHGEGPQDRYLVCYVVPAADTDPDPHQVRAHLADAL 4662 Query: 944 PEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGR 1003 P YMVP A + +P+T +GKLDR ALPAP A P E +C+ FA + G Sbjct: 4663 PGYMVPAAVVPLTALPLTPNGKLDRAALPAPDRAAWATGGAPTGPREEALCAAFADVLGV 4722 Query: 1004 QRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDF 1063 Q V + FF LGGHSL A RL+++IR+ GV++ +RT+F+APTPA L+ RL Sbjct: 4723 QEVSRDADFFALGGHSLSAVRLISRIRSALGVEIGIRTLFEAPTPAALSRRL-------- 4774 Query: 1064 ELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLAL 1123 D RP + RP R+PLS +Q WF +EG +N+PLAL Sbjct: 4775 ----DTAGT---------GRPRLLPRRRPDRVPLSSAQRRLWFLGELEGPSATYNIPLAL 4821 Query: 1124 RFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAID--QDEF 1181 R G RHEALRT F +G PYQ V + A+ +D + E Sbjct: 4822 RLRGRLDVDALRTALADVVGRHEALRTVFPSEDGAPYQQVVAAERAAPALDVVDVTEKEL 4881 Query: 1182 DDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYR 1241 + R H FT L+A LL GP HVL L++HHI D SL + DL AY Sbjct: 4882 PAALAEARAHAFTLTEDLPLRAVLLRTGPADHVLSLVLHHIAGDGWSLAPLARDLSTAYA 4941 Query: 1242 ARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEISVAT 1296 AR + APQW LP+Q+AD+ +W+ + + +L +WR+AL G P++I + T Sbjct: 4942 ARREGRAPQWRPLPVQYADHTLWKEELLGAADDPESLLARQLAFWREALEGAPEQIELPT 5001 Query: 1297 DRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIA 1356 DR RP + RG + +F++PA+ R L LA AT FM QA LA + LG G DI Sbjct: 5002 DRPRPAMESHRGAIHRFTLPASLRDRLRDLAHARRATLFMALQAGLAALFATLGAGRDIV 5061 Query: 1357 LGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIER 1416 LG+PVA R + A LVG F N + LRTDL GDPT +L R+ L A AHQ++P E+ Sbjct: 5062 LGTPVAGRADEAADDLVGFFVNTLALRTDLGGDPTFEELLDRVREADLSAFAHQDIPFEQ 5121 Query: 1417 LVEALNPPRALSRNPLFQNML----NFRGE 1442 LVEALNP R+LSR+P+FQ +L N RGE Sbjct: 5122 LVEALNPTRSLSRHPVFQVLLALQNNERGE 5151 Score = 639 bits (1649), Expect = 0.0 Identities = 494/1452 (34%), Positives = 688/1452 (47%), Gaps = 95/1452 (6%) Query: 44 LSDGQRRMWFLQTMDP--DDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGV 101 L+ Q + F T D +DV + +A G + R+ A V+ RH +LR + Sbjct: 2650 LAPAQEGLLFHSTFDDAAEDVYVGQ-LALEFHGELSGARMREAAQQVLDRHDVLRAAFLQ 2708 Query: 102 DTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVI 161 GE Q + V W DL+ L ER++++L A R FDL +R ++ Sbjct: 2709 RRSGEWSQAIAARTPVPWEEHDLSALAGEERERRLDALLAGHRTRRFDLARPPLVRFLLV 2768 Query: 162 RTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND----LPINDPAAQFLSVEVLQNSA 217 T AD VL + HH+ D S + +L A Y LP P +L+ Q++ Sbjct: 2769 TTAADRHVLAVTNHHLVLDGWSLPLVVRDLMALYGTDGAALPAVRPYRDYLAWLAGQDAD 2828 Query: 218 APSVADVGYWAETLRXXXXXXXXXGV--SGANPCRRAQRRVRPLPAGLFSRVEDFARKCS 275 A A WA+ L GA P R + + SR+ ++R+ Sbjct: 2829 AAHAA----WAQALAGLQPSLMAPDAPRDGAAPLAHH----RTMDPDVVSRLTAWSRRLG 2880 Query: 276 ASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA---LGYFGNTLLLRITTRSQ 332 + V+ A+ +L+ R TG D + + R GA +G NT+ +R+T Sbjct: 2881 VTLNSVVETAWALLLGRLTGRDDVSFGIAASGRPTDLPGAGEIVGLLMNTVPVRVTLDPA 2940 Query: 333 DTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLA 392 + + V V+ A HQ + + +V + D D + A GL Sbjct: 2941 EPLEALVRRVQREQAALLDHQFLPLAQVQQSLG----AGDLFDTTLVFENYPLAPADGLG 2996 Query: 393 LDGVVVRQLGL-GAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVD 450 DG +R G G H PLS+T+ PD + + F ++ L + V+ + + Q++D Sbjct: 2997 -DGDGLRLQGARGHDGNHYPLSVTVGPAPD-LQLRFIHRPDLFTPPWVEDLAARFEQVLD 3054 Query: 451 KALAEPERPLSSLDILGAGERDSVLAQ-SHGELV---EMPATTMVKXXXXXXXXXXXXXX 506 + P LDIL E D++L + GE E P + Sbjct: 3055 AMATSGDTPAGRLDILLPREHDTLLGDWARGEAASARECPVALFEEQVDRTPDVLALVEG 3114 Query: 507 XXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAA 566 D A L+Y+E RANR+AR+ I +G G ED++GL + + + LKAGAA Sbjct: 3115 ----GDGARLSYAEFDARANRMARFLIARGLGAEDLVGLVFPRGADLLTGLWGALKAGAA 3170 Query: 567 YLPIDPAYPDERIDYLITDARPQTVI-------------GRPELDVAERAAADN----SD 609 YLP+D YP ERI L+ D P V+ GR L V AD ++ Sbjct: 3171 YLPVDVDYPAERIALLLGDGNPALVLTTSAHAHLVPEAPGRQILCVDLPGPADELARAAE 3230 Query: 610 LPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRW- 668 ++DS+ RP+ P LAYV+YTSGSTGRPKGVAV ++A H + + DR+ Sbjct: 3231 GRVTDSELPRPVGPDTLAYVLYTSGSTGRPKGVAVGRGSLAAHA--------VRSRDRYP 3282 Query: 669 ------LQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXX 722 L S V+FD ++ +F TL G L++ + D S GVT Sbjct: 3283 DAAGVSLLHSPVAFDLTVTALFTTLISGGTLLLAELDEHAQDS---------GVTYVKGT 3333 Query: 723 XXXXXXXXXXXXXXQWRQLRH--VPVGGEALPGEVADRFAGYF-DAELRNHYGPTEAVV- 778 R + +GGE L GE+ +R+ + A + N YGP+E V Sbjct: 3334 PSHVALLNELPGVLDATAERPGTLVLGGEPLTGEMLERWRAHHPQARVFNDYGPSETSVN 3393 Query: 779 CSTHMVVTGSHGAR-VVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGR 837 CS ++ G+ ++PIG P + +VLD L PVP V+GE+Y+ G +ARGY GR Sbjct: 3394 CSDLLLEPGAEVPEGLLPIGRPLPGNHMFVLDHLLQPVPVGVVGEIYVSGVGVARGYHGR 3453 Query: 838 PTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESV 896 P LTA+RF+ P++ PG R+YRTGDL R G +E +GR D+QVK+RGFR+ELGEVE+ Sbjct: 3454 PGLTAERFLPCPYDAPGARMYRTGDLGRWRPDGIMECLGRTDDQVKVRGFRVELGEVEAA 3513 Query: 897 ITTHPAVRHCLVVAEETEAGPM-LAAYLVPAA---AQVDLEEIRAHTAAAVPEYMVPGAF 952 + V VV E E G L Y+VP A D AAA+P YMVP A Sbjct: 3514 LAARSDVARATVVVREDEPGDRRLTGYVVPEGGPDADFDPAAALRDLAAALPPYMVPAAI 3573 Query: 953 AVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSF 1012 V+ E+P T +GKLDRRALPAP R P TA E +C++FA + G + +D F Sbjct: 3574 VVLSELPRTENGKLDRRALPAPDYGTASVGRAPRTALETDLCALFADVLGVPGITLDDDF 3633 Query: 1013 FGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAA--RLVERFRNDFELDLDNL 1070 F LGGHSLLA RL +IRAE G+ L +RTIFD T A L A ++ + L Sbjct: 3634 FALGGHSLLAVRLAGRIRAELGLRLDIRTIFDHRTVADLLADPQIAAQLTGGL---LRGG 3690 Query: 1071 AADDMPLDPKRARPGFVKSAR--PQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGP 1128 ++ P ARP R P+RLPLS +Q WF R + +++ +ALR G Sbjct: 3691 TPEETPGPRVPARPAATPDPRALPERLPLSPAQRRLWFLNRYDREAGGYHISVALRLTGD 3750 Query: 1129 XXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIV-HPSRTVQLAVRAIDQDEFDDVSTQ 1187 RHE+LRT F E E P+Q+V P AV D + + Sbjct: 3751 LDVDALHAALGDLTARHESLRTVFREDEQGPHQVVLDPGAPPAPAVVPAAAHRIDALVRE 3810 Query: 1188 LRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHN 1247 R F L+ L L HVLLL++HHI +D S+ + DL AYRAR Sbjct: 3811 AVRRPFDLADDIPLRHTLFTLPDGEHVLLLVIHHIAADGWSMGPLARDLAAAYRARAAGR 3870 Query: 1248 APQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKR 1307 AP W + A + Q + L +W + L GLPDE+++ DR RP Sbjct: 3871 APDWPAPAARPAAHPPGQHGDDVDDTVDRRLAHWAEELRGLPDELALPYDRPRPTTPPGY 3930 Query: 1308 GEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEP 1367 E V F V AA + LA R+ AT FM+ AALA + H+LG G DI +G+P A R P Sbjct: 3931 AERVPFRVDAALYRDVRALAARHRATPFMVLHAALAALWHRLGAGPDIPVGTPSAGRDRP 3990 Query: 1368 ATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRAL 1427 TA LVG N +VLRTD SGDP +L R+T L A AHQ++P ERLVEA+NP R+ Sbjct: 3991 ETADLVGFLVNTLVLRTDTSGDPAFAELLDRVRETDLRAYAHQDVPFERLVEAVNPARSP 4050 Query: 1428 SRNPLFQNMLNF 1439 SR+PL Q ML F Sbjct: 4051 SRHPLVQTMLTF 4062 Score = 635 bits (1639), Expect = e-179 Identities = 519/1531 (33%), Positives = 721/1531 (47%), Gaps = 133/1531 (8%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R + Q +W Q + DD L C + V E+ L A+ VA LRT + Sbjct: 8 RVAATSAQTGIWTAQRLRGDD-RLYACGLFLELDHVVEEVLSEAIRRAVADTEALRTAFR 66 Query: 101 VDTEGEPYQVFSDDVEVGWRREDLTRL----PEAGHERQIESL--AADEFGRPFDLTNEL 154 D +G Q + TRL P G + SL + +P+DL + Sbjct: 67 EDADGALEQHV-----LARPPSTQTRLFHADPSGGTPSRSASLDWMDRQRAQPWDLASGD 121 Query: 155 PLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPIND--------PAAQ 206 R T+I D +L L HH+ D ++ L+A Y L P A+ Sbjct: 122 TCRHTLIPLGGDRSLLHLRYHHLALDGYGAALYLDRLAAVYRALRTGHQPPPCAFAPLAR 181 Query: 207 FLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXX-GVSGANPCRRAQRRVRPLPAGLFS 265 + + ++A AD +W + + A P A P L Sbjct: 182 LVEEDHAYRNSARHRADANHWRDRFADLPRPTSLADATTPAAPTTPATPAAPAAPDELRR 241 Query: 266 RVEDFARKCSA---------SPFMVLL-AAYGVLVRRYTGASDFLVSVPVTER-SGAAAG 314 V A + +A P+ V AA + R + +V +PVT R + AA Sbjct: 242 TVRLSAARSAALRRASDRSGRPWPVYATAAVAAFLSRLAPGEEVVVGLPVTARVTPAAVR 301 Query: 315 ALGYFGNTLLLRITTRSQDTFTSFVNEVR----ETCLAGFAHQSVGIDRVV--REANPER 368 G N + LR+ R Q T+ + E+ T L H++ I R + A P Sbjct: 302 TPGMLANVVPLRLPVR-QGMSTAELLELTAAEISTTLRHQRHRTEDIGRALGLHGAPPAT 360 Query: 369 MGRDGMDLLVRLGFN------MRKSAGGLALDGVVVRQLGL---GAVAAHLPLSLTIALD 419 + M L F + SAG ++ +VV LG G + L +T+A + Sbjct: 361 TLVNVMAFAPVLDFGDCRAPVHQLSAG--PVEDLVVNLLGTPGDGGESDGTELEITVAAN 418 Query: 420 PDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSH 479 P + S+ V + + + + E PL +L A E + +A+ H Sbjct: 419 P----------RLHSADAVASLAARLAEFLTHMGQDAEAPLGRTRLLDAEEEVAAVARGH 468 Query: 480 GELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGP 539 ++ A T+ + SD A TY++L A R+AR +G GP Sbjct: 469 SPRRDLRARTLPELFARQVARTPDAPAVS--SDRATWTYAQLDAHAERVARRLAARGVGP 526 Query: 540 EDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDV 599 E ++ L + +E +L + +AG AYLPIDP YP ER+ +L+ DARP ++G Sbjct: 527 ESLVALAVPRGVELAALILGIQRAGGAYLPIDPEYPAERVGFLLRDARPALLVGGTG--- 583 Query: 600 AERAAADNSDLP---LSDSDRLRPLR----PGHL-----AYVIYTSGSTGRPKGVAVSHH 647 E +AAD +P L D+ R PG L AYV++TSGSTGRPKGV V+H Sbjct: 584 TEPSAADCPRVPAEELLDAGACRAEADVPPPGSLPVDLPAYVVHTSGSTGRPKGVVVTHA 643 Query: 648 AIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYV 707 IA + + + R Q +++ FD ++A++ + L G+ L++P GD + Sbjct: 644 GIAALAAEQIERYRLGPGSRVAQLAALGFDVAVAELVMALASGSCLVLPPHGLAGD--EL 701 Query: 708 ADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAEL 767 A + R +T L + GGE P + R+A + Sbjct: 702 ASFLRDRRITTALAPAAVLATLPPGDLP----DLTDLVTGGEQPPPALIARWAP--GRRM 755 Query: 768 RNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGG 827 N YGPTEA V +T G R IG P V AYVLD L PVPD V GELYL G Sbjct: 756 FNVYGPTEATVQATSGRCAAD-GDRSPDIGNPEAGVDAYVLDAALRPVPDGVTGELYLRG 814 Query: 828 SQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRR---NHCGELEFVGRADEQVKI 883 LARGYLGRP LTA RF+ADP G R+YRTGDLVRR + L FVGRAD+QVKI Sbjct: 815 RGLARGYLGRPGLTAGRFVADPHTGTGERMYRTGDLVRRVPGDGRTVLRFVGRADDQVKI 874 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQ---VDLEEIRAHT 939 RGFR+E GEVE+ + V LV E G L YL PA +D+E +R Sbjct: 875 RGFRVEPGEVEAALAELDGVEQALVTVREERPGDRRLVGYLTPAPGHRGSLDVERLRRVL 934 Query: 940 AAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQ 999 A +P ++VP + EIP T +GK+DR ALP P P+A R P A E +C++FA+ Sbjct: 935 ADRLPAHLVPSLLMELAEIPRTANGKVDRAALPDPAPLAPTAGRAPRDAREEALCALFAE 994 Query: 1000 LFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERF 1059 + G + VG + FF LGG SLLAARL ++IR G +TVR +F +PT A LA L Sbjct: 995 VLGVEEVGVDLDFFALGGDSLLAARLASRIRGRLGKAVTVREVFRSPTVARLAEELG--- 1051 Query: 1060 RNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNM 1119 D DD + RP RP+RLPLS +Q WF + GA +N+ Sbjct: 1052 --------DGAVPDD---HVRPVRP------RPERLPLSSAQRRLWFIDELNGASAAYNI 1094 Query: 1120 PLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF-----DEHEGVPYQIVHPSRTVQLAVR 1174 P L EGP RHE LRT D G P Q + P + + Sbjct: 1095 PTVLHLEGPLDVPALHAALGDVTDRHETLRTTLRPPADDGSAGAPEQHIAPPGGHRPPLP 1154 Query: 1175 AIDQDEFDDVSTQLRR---HVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEI 1231 +D + ++ +LR HVF ++A L G H LLL+VHH+ +D AS+ Sbjct: 1155 VLDVAP-EALAGELRAAAGHVFDLARDLPVRATLYRTGELEHALLLLVHHVAADGASMGP 1213 Query: 1232 VFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTE-LDYWRDALAGLPD 1290 + DL AY ARL AP + +AD+A+W+R + E + Q E +DYWR ALAGLPD Sbjct: 1214 LIGDLATAYTARLAGRAPVLPPPEVTYADFALWERGSRERSAAQAEGIDYWRRALAGLPD 1273 Query: 1291 EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLG 1350 I + DR R + +RG + +F VP A A L +LA+ GAT FM+ Q A+AV+L ++G Sbjct: 1274 HIRLPADRPRSQEPVRRGGIARFEVPPALYAGLVELAQGVGATPFMVLQTAIAVLLSRMG 1333 Query: 1351 GGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 GTDI LG+PVA R + A LVG F N VVLRTD+SGDPT +L +RD L+ALAHQ Sbjct: 1334 AGTDIPLGTPVAGRQDEALDGLVGCFVNTVVLRTDVSGDPTTTELLARTRDGDLEALAHQ 1393 Query: 1411 ELPIERLVEALNPPRALSRNPLFQNMLNFRGEDW----ALVPRDLTGRGETTVVPLPVNF 1466 ++P +R+VEA+NP R+ SR+PLFQ ML G D A PR L R E TV P F Sbjct: 1394 DVPFDRVVEAVNPVRSTSRHPLFQVMLILNGSDQDRHRARFPR-LADRVE-TVEPGETKF 1451 Query: 1467 EVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 +++ F P L+ ++ ADL++ Sbjct: 1452 DLSWHFT---HRDGPDRSLEGALVHAADLFD 1479 Score = 418 bits (1074), Expect = e-114 Identities = 328/936 (35%), Positives = 450/936 (48%), Gaps = 70/936 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS QRR+WFL ++ T NI +A RL G +D D L TA+ DVV RH LRT + Sbjct: 4791 DRVPLSSAQRRLWFLGELEGPSATYNIPLALRLRGRLDVDALRTALADVVGRHEALRTVF 4850 Query: 100 GVDTEGEPYQ--VFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLR 157 + +G PYQ V ++ D+T E+++ + A+ F LT +LPLR Sbjct: 4851 PSE-DGAPYQQVVAAERAAPALDVVDVT-------EKELPAALAEARAHAFTLTEDLPLR 4902 Query: 158 ITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQ 206 ++RT + VL LV+HHI D S +LS AY LP+ Sbjct: 4903 AVLLRTGPADHVLSLVLHHIAGDGWSLAPLARDLSTAYAARREGRAPQWRPLPVQYADHT 4962 Query: 207 FLSVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLP 260 E+L + P + +W E L P + R LP Sbjct: 4963 LWKEELLGAADDPESLLARQLAFWREALEGAPEQIELP-TDRPRPAMESHRGAIHRFTLP 5021 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A L R+ D A A+ FM L A L D ++ PV R+ AA L G+F Sbjct: 5022 ASLRDRLRDLAHARRATLFMALQAGLAALFATLGAGRDIVLGTPVAGRADEAADDLVGFF 5081 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-DLL 377 NTL LR TF ++ VRE L+ FAHQ + +++V NP R + R + +L Sbjct: 5082 VNTLALRTDLGGDPTFEELLDRVREADLSAFAHQDIPFEQLVEALNPTRSLSRHPVFQVL 5141 Query: 378 VRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVL 437 + L N R A L+ V V + A L ++L + + +D + E + ++ L Sbjct: 5142 LALQNNERGEAVMPGLE-VTVERPAQAAAKYDLFVNLVESRNEEDGTTAVEGAVEYATDL 5200 Query: 438 VDQMLV-----HYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 D V Y L+ A+ EP LS + +L ERD + A+ G PA +V Sbjct: 5201 FDARTVARLTERYHDLLLAAVEEPTTRLSRMPMLDTAERDRLTAE-WGAAAAGPAEDLVA 5259 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 D LTY++L RA R+A G GPE + + + + + Sbjct: 5260 LFRARAAETPGAVAVRGAGDS--LTYAQLDERAGRIAAALARHGAGPESRVAVCLPRTAD 5317 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG----RPELDVAERAAADNS 608 + A+L VL+AGAAY+P+DP YPDER+ ++ D RP ++ RP + A AA Sbjct: 5318 LVAALLGVLRAGAAYVPLDPEYPDERVAAILADTRPVALLTTADCRPAITGAATAAGGAV 5377 Query: 609 DLPLSDSDRLRPLR------PGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTM 662 L + P+ P AYV++TSGSTGRPKGV VS +A + Sbjct: 5378 LLAADAAHGAGPVPEPPAPLPDQAAYVLHTSGSTGRPKGVVVSRGNLANLLADMRDRLRP 5437 Query: 663 TAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXX 722 TA+DR + ++VSFD + ++F+ L GA L++ A +A L++ G T+ Sbjct: 5438 TADDRLVAVTTVSFDIAALELFLPLVTGAGLVLADRGAARAPEELAALLTASGATLLQAT 5497 Query: 723 XXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCST- 781 R LR + VGGEALP +A R EL N YGPTE + ST Sbjct: 5498 PTTWQLLAETAPDAL-RGLRKL-VGGEALPASLASRLRE-LGGELVNVYGPTETTIWSTA 5554 Query: 782 -HMV-VTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPT 839 H+ VTGS PIG R AYVLDE L+P P+ V GELYL G+ +ARGYLGR Sbjct: 5555 AHLDRVTGS----APPIGRALRGTRAYVLDEWLNPRPENVPGELYLAGAGVARGYLGRGG 5610 Query: 840 LTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVIT 898 LTA+RF ADPF PG R+YRTGDLVRR GELEF+GR D QVK+RGFRIELGE+E+ + Sbjct: 5611 LTAERFTADPFGAPGSRMYRTGDLVRRRADGELEFLGRTDHQVKVRGFRIELGEIETALG 5670 Query: 899 THPAVRHCLVVAE---------ETEAGPMLAAYLVP 925 HP V +VVA + A L AY+VP Sbjct: 5671 AHPHVAGAVVVARAASGAALVPDAPAPRRLVAYVVP 5706 Score = 417 bits (1071), Expect = e-114 Identities = 400/1342 (29%), Positives = 569/1342 (42%), Gaps = 140/1342 (10%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS QRR+WF+ ++ NI L G +D LH A+ DV RH LRTT Sbjct: 1068 ERLPLSSAQRRLWFIDELNGASAAYNIPTVLHLEGPLDVPALHAALGDVTDRHETLRTTL 1127 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQI-------ESLAAD---EFGRPFD 149 +DD G + + P GH + E+LA + G FD Sbjct: 1128 RPP---------ADDGSAGAPEQHIA--PPGGHRPPLPVLDVAPEALAGELRAAAGHVFD 1176 Query: 150 LTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-----LPINDPA 204 L +LP+R T+ RT E LLL+VHH+ D S G+L+ AY P+ P Sbjct: 1177 LARDLPVRATLYRTGELEHALLLLVHHVAADGASMGPLIGDLATAYTARLAGRAPVLPPP 1236 Query: 205 AQFLSVEVL-----QNSAAPSVADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVR 257 + L + +A + YW L P RR Sbjct: 1237 EVTYADFALWERGSRERSAAQAEGIDYWRRALAGLPDHIRLPADRPRSQEPVRRGGIARF 1296 Query: 258 PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GAL 316 +P L++ + + A+ A+PFMVL A VL+ R +D + PV R A G + Sbjct: 1297 EVPPALYAGLVELAQGVGATPFMVLQTAIAVLLSRMGAGTDIPLGTPVAGRQDEALDGLV 1356 Query: 317 GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG--- 373 G F NT++LR T T + R+ L AHQ V DRVV NP R Sbjct: 1357 GCFVNTVVLRTDVSGDPTTTELLARTRDGDLEALAHQDVPFDRVVEAVNPVRSTSRHPLF 1416 Query: 374 MDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL 433 +L+ G + + V + G L T PD E Sbjct: 1417 QVMLILNGSDQDRHRARFPRLADRVETVEPGETKFDLSWHFTHRDGPDR---SLEGALVH 1473 Query: 434 SSVLVDQMLVHYL--QLVDKALA---EPERPLSSLDILGAGERDSVLAQSHGELVEMPAT 488 ++ L D H L +L+D A +P RP+ ++D+L A E V A G P + Sbjct: 1474 AADLFDDDTAHRLTARLLDVLTAMVDDPARPVGTIDVLSAAEHRLVRAWGTGT-PRPPGS 1532 Query: 489 TMVKXXXXXXXXXXXXXXXXXVSDEAEL-TYSELHRRANRLARWFIGQGFGPEDIIGLRM 547 V++ + +Y+EL RA+R+A +G G ED++ + + Sbjct: 1533 RPEPVAARIAGQAARTPDAPAVTEPGRVWSYAELDARADRVAAALAARGIGAEDLVAVLL 1592 Query: 548 ANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI---GRPEL------- 597 E + +L +L+AGAAYLP+D +P +R ++D+ P ++ GR Sbjct: 1593 PRGAELVATLLGILRAGAAYLPLDTGHPADRNRRALSDSAPALLVTDAGRSRTLRGETGC 1652 Query: 598 -------DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIA 650 + ER AD + LP + +RP+ + AY I TSGSTGRPK V V+ A+ Sbjct: 1653 AALVLGAEDTERELADRAPLPRDGAGLVRPVTGDNAAYTILTSGSTGRPKAVVVTRDALD 1712 Query: 651 EHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADL 710 V + + L S V+FD ++ ++ L G ++ V D G +A Sbjct: 1713 AFVDRALDTYGDALGGEALLHSPVAFDLTVVTLYGPLAAGGRVRVGDLDESG----IARW 1768 Query: 711 ISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFA---GYFDAEL 767 R V V + GE L G DR+ G + Sbjct: 1769 EKERPAFVKATPSHLALLTEFGGSTAPGT----VVLAGEQLIGARLDRWRTRLGASGTTV 1824 Query: 768 RNHYGPTEAVV-CSTHMVVTGSH-GARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYL 825 N YGPTE V C H + + + VP+G P V +LD++L PV V GELY+ Sbjct: 1825 LNSYGPTETTVNCLEHRIAPDADVPSGPVPVGRPVPGVRVLLLDDRLRPVAPGVTGELYV 1884 Query: 826 GGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIR 884 G +ARGY RP TA+RF+A P PG R+YRTGDL+R GEL + GRAD QVK+R Sbjct: 1885 CGPGVARGYRARPAATAERFVACPQGRPGERMYRTGDLMRWTADGELVYEGRADAQVKVR 1944 Query: 885 GFRIELGEVESVITTHPAVRHCLVV-------AEETEAGP-------MLAAYLVPAAAQ- 929 GFR+E GEVE+ + P VR V E E P L Y+V A+ + Sbjct: 1945 GFRVEPGEVEAALLGLPGVREAAVTLLEGPEGTEGPEGAPGRVAAPARLVGYVVGASEEP 2004 Query: 930 -VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETA 988 LE +R +P++MVP A + +P+T +GKLDRRALPAP R P Sbjct: 2005 AALLERLRVR----LPDHMVPAALVDLDALPLTPNGKLDRRALPAPDFGRHAGRRAPSGP 2060 Query: 989 TERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTP 1048 E +C++FA + G VGA+DSFF LGG S+++ +LV + R G+ LTVR +F+ PT Sbjct: 2061 EEEALCALFADVLGVPEVGADDSFFTLGGDSIVSIQLVGRARGA-GLHLTVRDVFEHPTA 2119 Query: 1049 AGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP-GFVKSARPQRLPLSHSQLAAWFQ 1107 AGLA + A D D +R P S +P + +A Sbjct: 2120 AGLAT-------------VVRSAGPD--ADAERPAPQALAPSGTLPYVPAAARLVARTGS 2164 Query: 1108 YRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEA--LRTNFDEHEGVPYQIVHP 1165 R GA + F+ + L H A LRT D ++ Sbjct: 2165 MRARGA-DRFHQSVVLTTPANAAADDVRRVLQTLIDHHGALRLRTAADRDGSPDGLVITE 2223 Query: 1166 SRTVQLA--VRAIDQDEFDDVSTQ--------LRRHVFTPESGPLLQANLLVLGPD-THV 1214 TV A +R D V+ + R P +G +L+A L G D + Sbjct: 2224 PGTVAAAGLLRCRDAAGLQGVALREAVEREAGHARDALDPSTGAVLRAAWLDRGKDRLGL 2283 Query: 1215 LLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWD-ILPIQFADYAVW-----QRNT 1268 L+L+ HH+ D S I+ DDL A+ +AP LP + A W +R T Sbjct: 2284 LVLVAHHLSVDGVSWRILADDLRQAWTPA---DAPATTATLPPEGASLREWATRIARRAT 2340 Query: 1269 FESNWGQTELDYWRDALAGLPD 1290 + G+ L +WR LAGL D Sbjct: 2341 ETAVTGR--LPHWRATLAGLDD 2360 Score = 119 bits (298), Expect = 4e-24 Identities = 60/121 (49%), Positives = 80/121 (66%), Gaps = 1/121 (0%) Query: 935 IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWIC 994 +R+H A +P+YMVP A V+ +P+T +GK+DR ALP P P T R P T E +C Sbjct: 6129 LRSHLAERLPDYMVPSAVVVLDALPLTANGKVDRNALPDPDPAGTDAGRPPRTPREELLC 6188 Query: 995 SIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAAR 1054 ++FA L G RVG +DSFFGLGG S+L+ RLV++ RA G+ LT R +F+ T A LAA Sbjct: 6189 TLFADLLGLGRVGVQDSFFGLGGDSVLSVRLVSRARAH-GLPLTTRDVFEHHTAAALAAA 6247 Query: 1055 L 1055 L Sbjct: 6248 L 6248 Score = 73.2 bits (178), Expect = 3e-10 Identities = 101/415 (24%), Positives = 162/415 (39%), Gaps = 34/415 (8%) Query: 1095 LPLSHSQLAAWFQYRIEGAREEFNM-PLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFD 1153 L L+ +Q F + A E+ + LAL F G RH+ LR F Sbjct: 2648 LALAPAQEGLLFHSTFDDAAEDVYVGQLALEFHGELSGARMREAAQQVLDRHDVLRAAFL 2707 Query: 1154 EHEGVPYQIVHPSRTV------QLAVRAIDQDE--FDDVSTQLRRHVFTPESGPLLQANL 1205 + + +RT L+ A ++ E D + R F PL++ L Sbjct: 2708 QRRSGEWSQAIAARTPVPWEEHDLSALAGEERERRLDALLAGHRTRRFDLARPPLVRFLL 2767 Query: 1206 LVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQ 1265 + D HVL + HH+V D SL +V DL+ Y A + P + DY W Sbjct: 2768 VTTAADRHVLAVTNHHLVLDGWSLPLVVRDLMALYGT---DGAALPAVRP--YRDYLAW- 2821 Query: 1266 RNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQ 1325 W ALAGL + +A D R G ++ + LT Sbjct: 2822 ---LAGQDADAAHAAWAQALAGLQPSL-MAPDAPRD---GAAPLAHHRTMDPDVVSRLTA 2874 Query: 1326 LAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVE--PATAQLVGLFANVVVLR 1383 + R G T + + A A++L +L G D++ G + R P ++VGL N V +R Sbjct: 2875 WSRRLGVTLNSVVETAWALLLGRLTGRDDVSFGIAASGRPTDLPGAGEIVGLLMNTVPVR 2934 Query: 1384 TDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGED 1443 L L +++ + L HQ LP+ ++ ++L LF L F E+ Sbjct: 2935 VTLDPAEPLEALVRRVQREQAALLDHQFLPLAQV------QQSLGAGDLFDTTLVF--EN 2986 Query: 1444 WALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYEP 1498 + L P D G G+ + + + ++V P+ +L ++ I DL+ P Sbjct: 2987 YPLAPADGLGDGDGLRLQGARGHDGN--HYPLSVTVGPAPDLQLRFIHRPDLFTP 3039 Score = 59.7 bits (143), Expect = 3e-06 Identities = 39/105 (37%), Positives = 59/105 (56%), Gaps = 5/105 (4%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E L + +LL + + +++F LGGDS+++++ ++A A GLP VFEH T A Sbjct: 6184 EELLCTLFADLLGLGRVGVQDSFFGLGGDSVLSVRLVSRARAHGLPLTTRDVFEHHTAAA 6243 Query: 1620 LAAAVDAANGEPVVEAD-PPPAQEYTPMSASGLAPDALAKLSASW 1663 LAAA+D EP E D PP + T +A + D LA+L A + Sbjct: 6244 LAAALDGR--EPESEPDGGPPGPDAT--AARPITLDELAELEAEF 6284 Score = 55.5 bits (132), Expect = 7e-05 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 3/102 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E L A+ ++L + + D+++F LGGDSI++I+ +A GL VFEH T A Sbjct: 2062 EEALCALFADVLGVPEVGADDSFFTLGGDSIVSIQLVGRARGAGLHLTVRDVFEHPTAAG 2121 Query: 1620 LAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSA 1661 LA V +A P +A+ P Q P P A A+L A Sbjct: 2122 LATVVRSAG--PDADAERPAPQALAPSGTLPYVP-AAARLVA 2160 Score = 47.8 bits (112), Expect = 0.014 Identities = 24/64 (37%), Positives = 41/64 (64%), Gaps = 1/64 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTIA 1618 E L A+ ++L + GI D+++FALGG S++A++ + + A LGL +F+H T+A Sbjct: 3611 ETDLCALFADVLGVPGITLDDDFFALGGHSLLAVRLAGRIRAELGLRLDIRTIFDHRTVA 3670 Query: 1619 ELAA 1622 +L A Sbjct: 3671 DLLA 3674 Score = 39.7 bits (91), Expect = 3.7 Identities = 23/63 (36%), Positives = 36/63 (57%), Gaps = 1/63 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMTIA 1618 E L A+ E+L + + D ++FALGGDS++A + +++ G LG VF T+A Sbjct: 985 EEALCALFAEVLGVEEVGVDLDFFALGGDSLLAARLASRIRGRLGKAVTVREVFRSPTVA 1044 Query: 1619 ELA 1621 LA Sbjct: 1045 RLA 1047 Score = 38.9 bits (89), Expect = 6.4 Identities = 26/74 (35%), Positives = 39/74 (52%), Gaps = 2/74 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L A ++L + + RD ++FALGG S+ A++ S ALG+ +FE T A Sbjct: 4709 EEALCAAFADVLGVQEVSRDADFFALGGHSLSAVRLISRIRSALGVEIGIRTLFEAPTPA 4768 Query: 1619 ELAAAVD-AANGEP 1631 L+ +D A G P Sbjct: 4769 ALSRRLDTAGTGRP 4782 >tr|Q9Z4X5|Q9Z4X5_STRCO Tax_Id=1902 (cdaPS2)SubName: Full=CDA peptide synthetase II;[Streptomyces coelicolor] Length = 3670 Score = 784 bits (2025), Expect = 0.0 Identities = 532/1445 (36%), Positives = 728/1445 (50%), Gaps = 87/1445 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+R+WFL ++ T NI RL G +D D L +A ND++ARH LRTTY Sbjct: 1033 ERIPLSYAQQRLWFLHQLEGPTATYNIPTTLRLTGTLDTDALQSAFNDLLARHESLRTTY 1092 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLA---ADEFGRPFDLTNELPL 156 D +G V + P A + E +A A+ FDL E+P+ Sbjct: 1093 TEDDQGAQQIVLPVEA---------VATPFAVVDVAAEDVAERVAEAAAHAFDLGAEIPV 1143 Query: 157 RITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPIND-PAAQFLSV----- 210 R + R E VLLL+VHHI D S +L+AAY +D PA Q L V Sbjct: 1144 RARLFRVSEREHVLLLLVHHIASDAWSRGPLAQDLTAAYTARCADDAPAWQPLPVQYADY 1203 Query: 211 -----EVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLP 260 E+L + P + YW + L A R +P Sbjct: 1204 ALWQQEILGDDTDPDTLAGRQLAYWKQQLAGLPEQLDLPTDRPRPATADHTGDRVTFTVP 1263 Query: 261 AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYF 319 A L +R+ + AR+ + + FMV+ AA L+ R+ D + PV R+ A L G+F Sbjct: 1264 ADLHTRLTELARETNTTAFMVIQAALAALLTRHGAGEDIPIGTPVAGRTDDATDHLIGFF 1323 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVR 379 NTL+LR T TF + VR+T L + HQ + +R+V NP R Sbjct: 1324 VNTLVLRTDTSGNPTFRDLLTRVRDTDLTAYTHQDLPFERLVEALNPTRSLTHHPLFQTM 1383 Query: 380 LGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIA--LDPDDVSVEFEYQQQLSSVL 437 L + + G+ + +V+A LS +A D S+ L Sbjct: 1384 LTLHNTQGTKTDRFAGLAAEVVASESVSARFDLSFALAEHFGADHSCAGMSGGVTYSTAL 1443 Query: 438 VDQMLVHYL-----QLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 D+ V L +L+ A+A P R + L+I+ A ER VL + + E PA ++ Sbjct: 1444 FDRATVRDLADRLVRLLAAAVAHPGRSVGQLEIMDAAERRLVLQEWNDTAAEPPAASVTG 1503 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 E L+Y+EL+ RANRLAR + +G P + + + S E Sbjct: 1504 LFERQARRSPGATALEF--GEVRLSYAELNARANRLARHLVARGAAPGRFVAVALPRSAE 1561 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPL 612 +V +LAVLK+GAAYLPIDP YP +R++Y++ DA P + P VAE + D L Sbjct: 1562 LVVTLLAVLKSGAAYLPIDPHYPADRVEYMLADAGPALTVTEP---VAEAGLSGYGDADL 1618 Query: 613 SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFS 672 + P+ H AY IYTSGSTGRPKGV V A+ + +T + DR L + Sbjct: 1619 GADELRGPVHGAHPAYTIYTSGSTGRPKGVVVPRGALDNFLADMGRRFTPGSGDRLLAVT 1678 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 +V FD + +IF+ L GA L++ + D + +S G+T+ Sbjct: 1679 TVGFDIAGLEIFLPLLHGAVLVLADEETARDPHALLHRVSASGITMVQATPSLWQGVAAV 1738 Query: 733 XXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGAR 792 + +R V VGGEALP E+A + + N YGPTEA + +T V S Sbjct: 1739 AGD-ELAGVR-VLVGGEALPSELARALTDRARS-VTNLYGPTEATIWATAADVAESGPV- 1794 Query: 793 VVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP 852 IG P N AYVLD L PVP V GELYL G QLA+GY RP LT++RF ADP+ P Sbjct: 1795 ---IGRPLANTSAYVLDSALRPVPVGVPGELYLAGEQLAQGYHLRPALTSERFTADPYGP 1851 Query: 853 -GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE 911 G R+YRTGDLV R G L ++ R D+QVK+RGFRIELGE+E+ ++ HPAV V Sbjct: 1852 AGTRMYRTGDLVCRRRDGALRYLSRVDQQVKLRGFRIELGEIEAELSRHPAVAESAVTVR 1911 Query: 912 ETEAGPM-LAAYLVPAAAQ---------VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMT 961 E G L Y+VP + E+R +PE+MVP AF V+ +P+T Sbjct: 1912 EDRPGDRRLVGYVVPKGPEGPAGPTGPVPSARELRERLRGRLPEFMVPTAFVVLDALPLT 1971 Query: 962 VSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLL 1021 + KLDR+ALPAP R P E +C++FA++ G RVG +D FF LGGHSLL Sbjct: 1972 PNRKLDRKALPAPEYDGEPVGRGPRDPREEILCALFAEVLGVARVGIDDGFFDLGGHSLL 2031 Query: 1022 AARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKR 1081 A RLV++IR GV+L+VR F+ PT AGL+ L D A PL Sbjct: 2032 ATRLVSRIRTALGVELSVRQFFETPTIAGLSGAL------------DRAAGARAPL---A 2076 Query: 1082 ARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXX 1141 ARP RP+R+PLS +Q WF ++ EG +NMP ALR GP Sbjct: 2077 ARP------RPERVPLSPAQQRLWFLHQFEGPSATYNMPTALRLSGPVDRAALERAIGDV 2130 Query: 1142 XXRHEALRTNFDEHEGVPYQIVHPS-RTV-QLAVRAIDQDEFDDVSTQLRRHVFTPESGP 1199 RHE+LRT F +G +Q+V P+ R V +L V + E + + RH F + Sbjct: 2131 LVRHESLRTVFAADDGGSWQVVLPADRAVGRLDVVDVTAGEVAERVGEAARHAFDLTADI 2190 Query: 1200 LLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFA 1259 A L + HVLLL++HHI D S+ + DL AY AR AP W+ LP+Q+A Sbjct: 2191 PFLARLFRVSDTEHVLLLLIHHIAGDGWSMAPLARDLTAAYAARCAGAAPDWEPLPVQYA 2250 Query: 1260 DYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFS 1314 DYA+WQR + +L YW+DALAGLP+++ + TDR RP G G+ + F+ Sbjct: 2251 DYALWQREVLGDESDPDSVAARQLAYWKDALAGLPEQLELPTDRPRPATAGYTGDRIAFT 2310 Query: 1315 VPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVG 1374 VP A A LT+LA ++ FM+ QAA A +L +LG G DI +G+ VA R + AT LVG Sbjct: 2311 VPTALHARLTELARSTHSSLFMVVQAAFATLLTRLGAGEDIPVGTAVAGRNDAATEDLVG 2370 Query: 1375 LFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQ 1434 F N +VLRTD G+PT R +L R+ L A AHQ++P ERLVEALNP R+L+ +PL+Q Sbjct: 2371 FFVNTLVLRTDTGGNPTFRELLGRVRERDLAAYAHQDVPFERLVEALNPARSLAHHPLYQ 2430 Query: 1435 NMLNF 1439 M+ F Sbjct: 2431 VMITF 2435 Score = 687 bits (1774), Expect = 0.0 Identities = 476/1404 (33%), Positives = 681/1404 (48%), Gaps = 96/1404 (6%) Query: 68 VAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRL 127 VA+ L G D R+ A ++ RHA LR + G Q+ DV++ W+ DL+ L Sbjct: 43 VAFDLEGPFDGARMREAARALLRRHANLRAGFRQRKNGAWAQLVLRDVDLPWQDADLSTL 102 Query: 128 PEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVF 187 E + + LAA + R FDL LR T IR AD + L++ HHI D S V Sbjct: 103 SEEERRAEADRLAAADRARRFDLGRPPLLRFTAIRLSADRVRLVMTNHHIVLDGWSMPVL 162 Query: 188 FGELSAAY------NDLPINDPAAQFLS-VEVLQNSAAPSVADVGYWAETLRXXXXXXXX 240 EL A Y + LP P +L+ ++ AA W +L Sbjct: 163 LRELMALYAAEGDPSALPRVRPYRDYLAWLDARDRDAARDA-----WRRSLSGLDEATLL 217 Query: 241 XGVSGANPCRRAQRRVR-PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDF 299 A P A +V + + + + +AR + V+ A+ + + + TG D Sbjct: 218 --APDAGPASTAPSQVSFTVDSEVSGALSAWARGQGVTMNTVVQGAWALALAQATGRDDV 275 Query: 300 LVSVPVTERSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVG 356 + V+ R G +G F NTL +R + ++ HQ G Sbjct: 276 VFGATVSGRPPELPGVESMIGLFINTLPVRARLDQAEPLGDLFRRLQNEQARLLDHQWPG 335 Query: 357 IDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLAL----DGVVVRQLGLGAVAAHLPL 412 + + A + M N G L D + V + H + Sbjct: 336 LADIQHWAGHGELFDTAMVFQ-----NYPVEEGDLTAPADPDRLRVASADIKG-GTHFAV 389 Query: 413 SLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGER 471 ++ + ++S +Y+ L L++++ +++P+RP++ LD L R Sbjct: 390 NVVATMRGAELSFRVDYRPDLYDEAYARDFGRRMLRVLETLISDPDRPVAHLDTLDPAVR 449 Query: 472 DSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARW 531 + VL + +G ++P T + + V D LTY+EL RAN+LAR Sbjct: 450 ERVLVEWNGAPTQLPGTPLHELISEQARLTPDAVAV--VCDGTSLTYAELDGRANQLARH 507 Query: 532 FIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTV 591 + +G G ED + + + S++ + +MLAVLK GAAYLPIDP YP ERI Y++ DARP Sbjct: 508 LLERGLGAEDFVAIALHKSLDAVTSMLAVLKTGAAYLPIDPDYPAERITYMLDDARPALT 567 Query: 592 IGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAE 651 + P V A ++D++R P H AY+IYTSGSTGRPKGV + HHA+A Sbjct: 568 LREP---VPAAAYGHRPTDDVTDAERRTPWSALHAAYMIYTSGSTGRPKGVVIEHHALAT 624 Query: 652 HVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVP-------KPDAFGDI 704 ++ +T L S ++FD ++ ++ L G + + +P Sbjct: 625 YLHRARNTYTAMTGVTVLH-SPLAFDLTITALWTPLTAGGTVHLTSLEEAEVQPSLIKAT 683 Query: 705 SYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEAL-PGEVADRFAGYF 763 L++ T +GGEAL ++ D + Sbjct: 684 PSHLPLLTNLAATASPSHTLI--------------------LGGEALHTDQLTDWRTQHP 723 Query: 764 DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGEL 823 A++ N YGPTE+ V T + G+ V PIG P N YVLD L PV GEL Sbjct: 724 GAQIINAYGPTESTVNITDHRLDGTEEGPV-PIGRPFANTQVYVLDSALRPVAPGTTGEL 782 Query: 824 YLGGSQLARGYLGRPTLTAQRFIADPFN--PGMRLYRTGDLVRRNHCGELEFVGRADEQV 881 YL G QLARGYLGRP LTA+RF A+P + PG R+YRTGDL NH G L + GRAD Q+ Sbjct: 783 YLAGEQLARGYLGRPALTAERFTANPHSSVPGARMYRTGDLAHWNHHGHLTYDGRADHQI 842 Query: 882 KIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQVDLEEIRAHTA 940 K+RG RIE GE+E+ +T + V E + G L AYLV + D +R Sbjct: 843 KLRGHRIEPGEIETTLTAQTGITQATVQLREDQPGDQRLVAYLVTSTGY-DENTVRDALV 901 Query: 941 AAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQL 1000 +A+P+YMVP A + +P+T +GKLDR ALPAP A+ R P T E +C++++++ Sbjct: 902 SALPDYMVPSALVTLDALPLTPNGKLDRTALPAPAYSASTTGRTPRTPREEILCTLYSEI 961 Query: 1001 FGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFR 1060 VG +DSFF LGGHSLLA RLV++IR G +L +R +F+ PT AGL+ Sbjct: 962 LSVNTVGIDDSFFDLGGHSLLATRLVSRIRTTLGRELPIRQLFETPTVAGLSR------- 1014 Query: 1061 NDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMP 1120 LD + ARP RP+R+PLS++Q WF +++EG +N+P Sbjct: 1015 ---ALDTSGTLRTAL-----TARP------RPERIPLSYAQQRLWFLHQLEGPTATYNIP 1060 Query: 1121 LALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAID--Q 1178 LR G RHE+LRT + E + QIV P V +D Sbjct: 1061 TTLRLTGTLDTDALQSAFNDLLARHESLRTTYTEDDQGAQQIVLPVEAVATPFAVVDVAA 1120 Query: 1179 DEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIV 1238 ++ + + H F + ++A L + HVLLL+VHHI SD S + DL Sbjct: 1121 EDVAERVAEAAAHAFDLGAEIPVRARLFRVSEREHVLLLLVHHIASDAWSRGPLAQDLTA 1180 Query: 1239 AYRARLQHNAPQWDILPIQFADYAVWQR-----NTFESNWGQTELDYWRDALAGLPDEIS 1293 AY AR +AP W LP+Q+ADYA+WQ+ +T +L YW+ LAGLP+++ Sbjct: 1181 AYTARCADDAPAWQPLPVQYADYALWQQEILGDDTDPDTLAGRQLAYWKQQLAGLPEQLD 1240 Query: 1294 VATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGT 1353 + TDR RP G+ V F+VPA LT+LA T FM+ QAALA +L + G G Sbjct: 1241 LPTDRPRPATADHTGDRVTFTVPADLHTRLTELARETNTTAFMVIQAALAALLTRHGAGE 1300 Query: 1354 DIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELP 1413 DI +G+PVA R + AT L+G F N +VLRTD SG+PT R +L RDT L A HQ+LP Sbjct: 1301 DIPIGTPVAGRTDDATDHLIGFFVNTLVLRTDTSGNPTFRDLLTRVRDTDLTAYTHQDLP 1360 Query: 1414 IERLVEALNPPRALSRNPLFQNML 1437 ERLVEALNP R+L+ +PLFQ ML Sbjct: 1361 FERLVEALNPTRSLTHHPLFQTML 1384 Score = 517 bits (1332), Expect = e-144 Identities = 439/1370 (32%), Positives = 604/1370 (44%), Gaps = 127/1370 (9%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+R+WFL + T N+ A RL+G VD L A+ DV+ RH LRT + Sbjct: 2082 ERVPLSPAQQRLWFLHQFEGPSATYNMPTALRLSGPVDRAALERAIGDVLVRHESLRTVF 2141 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 D G V D VG R D+ + ++ + FDLT ++P Sbjct: 2142 AADDGGSWQVVLPADRAVG--RLDVVDVTAG----EVAERVGEAARHAFDLTADIPFLAR 2195 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFL 208 + R E VLLL++HHI D S +L+AAY LP+ Sbjct: 2196 LFRVSDTEHVLLLLIHHIAGDGWSMAPLARDLTAAYAARCAGAAPDWEPLPVQYADYALW 2255 Query: 209 SVEVLQNSAAP-SVA--DVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLPAGL 263 EVL + + P SVA + YW + L A R +P L Sbjct: 2256 QREVLGDESDPDSVAARQLAYWKDALAGLPEQLELPTDRPRPATAGYTGDRIAFTVPTAL 2315 Query: 264 FSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNT 322 +R+ + AR +S FMV+ AA+ L+ R D V V R+ AA L G+F NT Sbjct: 2316 HARLTELARSTHSSLFMVVQAAFATLLTRLGAGEDIPVGTAVAGRNDAATEDLVGFFVNT 2375 Query: 323 LLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGF 382 L+LR T TF + VRE LA +AHQ V +R+V NP R V + F Sbjct: 2376 LVLRTDTGGNPTFRELLGRVRERDLAAYAHQDVPFERLVEALNPARSLAHHPLYQVMITF 2435 Query: 383 NMRKSAG--------------GLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDD 422 N AG G A + ++ G A L+LT P Sbjct: 2436 NNTAGAGDRTAPASPDTPDVSGQAGALLNATRMTAGTGVAKFDLALTFGERHDPSGGPAG 2495 Query: 423 VSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGE 481 + EY+ +L + ++ L ++ A+P+RP+ + +L ER VL + + Sbjct: 2496 MRGSLEYRTELFDRETAESVISRLLGVLGSVTADPDRPIGGIGLLDPAERRQVLREWNDT 2555 Query: 482 LVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPED 541 T+ + LTY+EL+ RANRLA G GPE Sbjct: 2556 ARPQREGTLPRLFEEQVARTPRRPAFSAAG--TTLTYAELNSRANRLAHLLAESGAGPEQ 2613 Query: 542 IIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR------- 594 ++ + + S+E VA+LAVLK GAAYLP+DP P ERI + DA P + Sbjct: 2614 VVAISLPPSVEMGVAVLAVLKTGAAYLPVDPGSPRERIATMAEDAAPVCALTTSAVPAGV 2673 Query: 595 -----PEL-----DVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAV 644 P L DV R AA + L+D DR +PL P + AY+IYTSGSTGRPKGV V Sbjct: 2674 FPAELPRLLLDDPDVTARLAAQPAH-DLTDEDRTQPLSPWNAAYIIYTSGSTGRPKGVLV 2732 Query: 645 SHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDI 704 H + ++ AE L S +SFD ++ +F L G + Sbjct: 2733 EHQPVLNYL-AVSAELYPGVAGNALLHSPLSFDLTVTGLFAPLLNGGCV----------- 2780 Query: 705 SYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVP----------VGGEALPGE 754 ++ADL + + +P +GGE+L G Sbjct: 2781 -HLADLEELHARALDGEVPDLPQTTFLKATPSHLPLITGLPGVCVPDGELVLGGESLTGR 2839 Query: 755 -VADRFAGYFDAELRNHYGPTEAVV-CSTHMVVTGSHGAR-VVPIGVPNRNVYAYVLDEQ 811 V A + A + N YGPTE +V C+T V A V+ IG P N VLD Sbjct: 2840 AVRTLLAAHPGARVLNEYGPTETIVGCTTWRVEAPDDLADGVLTIGRPFPNTRMLVLDPY 2899 Query: 812 LHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGE 870 L PVP V GELY+ G QLARGYL RP +A RF+A+PF PG R+YRTGD+VR N G+ Sbjct: 2900 LQPVPAGVPGELYVSGVQLARGYLNRPGQSASRFVANPFEGPGERMYRTGDIVRWNRRGD 2959 Query: 871 LEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQ 929 LEF+ R D+QVKIRGFR+ELGEVES ++ P V + V E G L AYLV A Sbjct: 2960 LEFISRVDDQVKIRGFRVELGEVESALSRQPGVPEAVAVVREDRPGDRRLVAYLVTGAGP 3019 Query: 930 VDL---EEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPE 986 V + EE+R +P+YMVP AF +PE+P+T +GKLDR LPAP A R P Sbjct: 3020 VPVPSDEELRERLRETLPDYMVPSAFVRLPELPLTGNGKLDRGRLPAPDYAAAGTGRAPV 3079 Query: 987 TATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAP 1046 TA E +C++FA+ G + VG +D FF LGG S+L+ +LV++ RA+ G+ L+VR +F+ Sbjct: 3080 TAREELLCALFAEALGLESVGVDDGFFDLGGDSILSIQLVSRARAK-GLTLSVRDVFEHQ 3138 Query: 1047 TPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWF 1106 + A +A L EL + AAD A PG + P+ + + WF Sbjct: 3139 SVARVAEAL--------EL-AEAQAADGAAGASAGAVPGAAEEEAAASGPVPATPIMGWF 3189 Query: 1107 QYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF--DEHEGVPYQIVH 1164 + G FN + + RH++LR D VP Sbjct: 3190 A-ALGGPVAPFNQSVVVSVPADLDAERLVAALGALLDRHDSLRLRVAADWSMSVPEPEPG 3248 Query: 1165 PSRTVQLAVRAIDQDEFDDVSTQ--------LRRHVFTPESGPLLQANLLVLGPD-THVL 1215 + L R D DD R +P G +L+A + GPD +L Sbjct: 3249 GTDAAGLLTRRAAGD-VDDAGLHALLAEAGAAERDRLSPADGRMLRACHVDRGPDRPGLL 3307 Query: 1216 LLIVHHIVSDHASLEIVFDDLIVAYRAR-LQHNAPQWDILPIQFADYAVWQRNTFESNWG 1274 +L+ HH+ D S ++ DL AY R L W +A R+ S Sbjct: 3308 VLVAHHLAVDAVSWRLLVPDLAAAYEGRPLSPAGTGW-------RRWASALRDLAGSPVT 3360 Query: 1275 QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALT 1324 + E D+W DA + D AR + G+VV P A LT Sbjct: 3361 EAETDHWLDAARPAAEPADPVLDPARD-THARSGQVVLDLDPDTTDALLT 3409 Score = 54.3 bits (129), Expect = 1e-04 Identities = 34/99 (34%), Positives = 51/99 (51%), Gaps = 5/99 (5%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E L A+ E L + + D+ +F LGGDSI++I+ ++A A GL VFEH ++A Sbjct: 3083 EELLCALFAEALGLESVGVDDGFFDLGGDSILSIQLVSRARAKGLTLSVRDVFEHQSVAR 3142 Query: 1620 LAAAVD-----AANGEPVVEADPPPAQEYTPMSASGLAP 1653 +A A++ AA+G A P +ASG P Sbjct: 3143 VAEALELAEAQAADGAAGASAGAVPGAAEEEAAASGPVP 3181 Score = 42.0 bits (97), Expect = 0.75 Identities = 31/90 (34%), Positives = 47/90 (52%), Gaps = 4/90 (4%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E L A+ E+L + + D+ +F LGG S++A + ++ ALG+ FE TIA Sbjct: 2000 EEILCALFAEVLGVARVGIDDGFFDLGGHSLLATRLVSRIRTALGVELSVRQFFETPTIA 2059 Query: 1619 ELAAAVD-AANGEPVVEADPPPAQEYTPMS 1647 L+ A+D AA + A P P E P+S Sbjct: 2060 GLSGALDRAAGARAPLAARPRP--ERVPLS 2087 Score = 38.9 bits (89), Expect = 6.4 Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 2/89 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L + E+L + + D+++F LGG S++A + S LG P +FE T+A Sbjct: 951 EEILCTLYSEILSVNTVGIDDSFFDLGGHSLLATRLVSRIRTTLGRELPIRQLFETPTVA 1010 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 L+ A+D +G P E P+S Sbjct: 1011 GLSRALD-TSGTLRTALTARPRPERIPLS 1038 >tr|A8M6W3|A8M6W3_SALAI Tax_Id=391037 SubName: Full=Amino acid adenylation domain;[Salinispora arenicola] Length = 7785 Score = 781 bits (2018), Expect = 0.0 Identities = 519/1443 (35%), Positives = 733/1443 (50%), Gaps = 103/1443 (7%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++ T N +A RL+G ++ L A+ DVV RH LRT + +T Sbjct: 2001 LSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTALRAALGDVVGRHEALRTVFA-ET 2059 Query: 104 EGEPYQVFSD--DVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVI 161 +G PYQ D DV++ R LP + D FDL E+P+R + Sbjct: 2060 DGVPYQKVLDVADVDLSVREVAADELP---------GVLRDAARYEFDLAREIPVRAWLF 2110 Query: 162 RTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-----------LPINDPAAQFLSV 210 E VL+LV+HHI D S +L+ AY D LP+ Sbjct: 2111 AAGPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPLPVQYADYTLWQR 2170 Query: 211 EVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP--------- 258 +L + A P + YW L P R + + Sbjct: 2171 RLLGDEADPDSVFGRQLAYWRGQLAGLPQQVTL-------PTDRPRPQTASYAGDVTMFR 2223 Query: 259 LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-G 317 L AGL + + AR A+ FMVL AA ++ R D + P+ RS L G Sbjct: 2224 LDAGLHADLLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDGLDDLVG 2283 Query: 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLL 377 +F NTL+LR T F + VR+T L +AHQ V + +V + NP R Sbjct: 2284 FFVNTLVLRADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTAHSPLFQ 2343 Query: 378 VRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVSVEFEYQQ 431 V L F S L G+ + +G + + L+L I P + EY Sbjct: 2344 VLLAFQ-NNSDTSFHLPGLRAEREEIGTRVSRVDLTLNITEAFGVNGAPQGIRGAVEYAT 2402 Query: 432 QLSSV-LVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTM 490 L V+ +++++ A+A+P R ++++D+L E +VLA S G +P + Sbjct: 2403 DLYDARTVESFAARFVRMLQAAVADPSRRINAVDLLSDEENATVLALS-GRDAAVPESR- 2460 Query: 491 VKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANS 550 V V + TY++L+ ANRLAR+ I +G GPED++G+ M S Sbjct: 2461 VWPAVFEATAAAAPDATAVVEGQLSWTYAQLNANANRLARYLIDRGVGPEDVVGVLMPRS 2520 Query: 551 IEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG-RPELDVAERAAADNS- 608 I +LA+ KAGAA+LPIDPAYP ER++YLI DARP+ ++ + VA A A + Sbjct: 2521 AMQIATVLAIGKAGAAFLPIDPAYPAERVEYLIADARPKMLLADTAHVGVAAGAIAIDEP 2580 Query: 609 -------DLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWT 661 + P++D + +R H AYVIYTSGSTGRPKG V+H +A Sbjct: 2581 AVATALREAPVTDPAGVA-VRLEHPAYVIYTSGSTGRPKGTIVTHSGLAALAVSGCERAA 2639 Query: 662 MTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXX 721 + + R LQ +S SFD S+ + GA L++P+P +A+L++ GV+ Sbjct: 2640 VDRDSRVLQLTSPSFDVSVFEFLAAFHAGAVLVMPEPGRLAG-EELAELLADAGVS-HAF 2697 Query: 722 XXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCST 781 + LR + VGGEA ++ R++ + N YGPTE V ++ Sbjct: 2698 VPPSVLATLPDEAPGRLAGLRSLVVGGEACSADLVRRWS--VGRRMTNLYGPTETTVAAS 2755 Query: 782 --HMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPT 839 + TG+H PIG P YVLD L PVP GELY+ G +ARGYLGRP Sbjct: 2756 ISRPMSTGAH-----PIGAPLPGTRVYVLDANLRPVPPGARGELYISGIGVARGYLGRPV 2810 Query: 840 LTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVIT 898 LTA RF+ADPF P G R YRTGD+VR N GELE+ GR+D Q+KIRGFR+E GE+E+ + Sbjct: 2811 LTASRFVADPFGPAGARAYRTGDVVRWNADGELEYFGRSDHQLKIRGFRVEPGEIEAALV 2870 Query: 899 THPAVRHCLVVAEETEAG-PMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPE 957 P+V +VVA + G L AY+ A D +R A +P+Y+VP A V+ E Sbjct: 2871 RRPSVAQAVVVARPDQHGFQALYAYVTAGAEPADAARLREELRAELPDYLVPAAIVVLDE 2930 Query: 958 IPMTVSGKLDRRALPAPTPIATRR-YREPETATERWICSIFAQLFGRQRVGAEDSFFGLG 1016 P+ +GKLDR ALP P + + R P E + S+FA + G +R+ A+D+FF LG Sbjct: 2931 FPLNANGKLDRNALPEPRFVTSAADIRSPGMPQEEILRSVFADVLGIERISADDNFFDLG 2990 Query: 1017 GHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMP 1076 GHSLL RL++++R GVD++++T F+APTP LA +L+E P Sbjct: 2991 GHSLLVTRLISRVRGTLGVDVSMQTFFNAPTPRQLAGQLLE----------------GGP 3034 Query: 1077 LDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXX 1136 + P R +P RP+ LPLS +Q WF +++EG +N PLA++ G Sbjct: 3035 V-PARLQP----VPRPEALPLSFAQQRLWFLHKLEGPSATYNSPLAIKLSGELDVDALRL 3089 Query: 1137 XXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPE 1196 RHEALRT F E G PYQ + S V+L VR + Q + D + R+ F Sbjct: 3090 ALADVVVRHEALRTVFAERAGNPYQRILDSAEVELPVREVPQSKLPDALREAARYEFDLA 3149 Query: 1197 SGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPI 1256 L+A L GP VL+L +HH+V+D SL+++ +L AY +R +AP W LP+ Sbjct: 3150 REIPLRAWLFTAGPGEWVLMLALHHVVADGWSLQVLVSNLTAAYTSRRAGHAPSWQPLPV 3209 Query: 1257 QFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV 1311 Q+ADY +WQR + + ++ YW + LA LPD++++ TDR RP V RGE V Sbjct: 3210 QYADYTLWQRRHLGTEDDPDSVSSRQVSYWLEQLADLPDQVTLPTDRPRPAVASYRGETV 3269 Query: 1312 QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQ 1371 F + A A L +LA G T FM+ QAALA +L +LG GTDIA+GSP+A R + Sbjct: 3270 TFDLDAEEHAELVRLARETGTTLFMILQAALAGLLTRLGAGTDIAIGSPIAGRTDDRLEN 3329 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 L+GLF N++VLRTD GDPTL +L R+T L A AHQ +P E LVE LNP R+ + +P Sbjct: 3330 LIGLFVNMLVLRTDTGGDPTLGELLTRVRETSLAAYAHQHMPFEYLVERLNPHRSAAHHP 3389 Query: 1432 LFQ 1434 L Q Sbjct: 3390 LVQ 3392 Score = 745 bits (1923), Expect = 0.0 Identities = 509/1428 (35%), Positives = 712/1428 (49%), Gaps = 101/1428 (7%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++ T N +A RL+G ++ L A+ DVV RH LRT + +T Sbjct: 4071 LSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTALRAALGDVVGRHEALRTVFA-ET 4129 Query: 104 EGEPYQVFSD--DVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVI 161 +G PYQ D DV++ R LP + D FDL E+P+R + Sbjct: 4130 DGVPYQKVLDVADVDLSVREVAADELP---------GVLRDAARYEFDLAREIPVRAWLF 4180 Query: 162 RTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-----------LPINDPAAQFLSV 210 E VL+LV+HHI D S +L+ AY D LP+ Sbjct: 4181 AAGPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPLPVQYADYTLWQR 4240 Query: 211 EVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP--------- 258 +L + A P + YW L P R + + Sbjct: 4241 RLLGDEADPDSVFGRQLAYWRGQLAGLPQQVTL-------PTDRPRPQTASYAGDVTMFR 4293 Query: 259 LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-G 317 L AGL + + AR A+ FMVL AA ++ R D + P+ RS L G Sbjct: 4294 LDAGLHADLLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDGLDDLVG 4353 Query: 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLL 377 +F NTL+LR T F + VR+T L +AHQ V + +V + NP R Sbjct: 4354 FFVNTLVLRADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTAHSPLFQ 4413 Query: 378 VRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSV--EFEYQQQL-S 434 V L F S L G+ R G+ + + L +++A PD V EY L Sbjct: 4414 VLLAFQ-NNSDTSFHLPGLRTRLEGVSTGLSRVDLFISLAEQPDAGGVIGAVEYATDLYD 4472 Query: 435 SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 + V+ + +L+ + +PE+ + S+D+L GER+ + ++ E PAT Sbjct: 4473 AATVEAFVGRWLRFLAAVAHDPEQRIGSVDLLLDGERERLTGWAYTEPEVEPATLS---E 4529 Query: 495 XXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFI 554 V E +Y+ L+ ANR+A + +G G ED++ + + + Sbjct: 4530 LFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAVQV 4589 Query: 555 VAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSD 614 +L V+KAGAAYLP+DP+YP R++YL+ DA P VIG E DV + + Sbjct: 4590 ATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIG--ESDVFDGQP---------E 4638 Query: 615 SDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSV 674 D +RP+ AYVIYTSGSTG+PKGV V+H +A G V + + R L +S Sbjct: 4639 HDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLAALATGTVGRNAVAGDSRVLLLASP 4698 Query: 675 SFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXX 734 SFDAS+ ++ + + GA L+V + +A LI++ VT Sbjct: 4699 SFDASVLELMIAIGAGAALVVSRESRLAG-EELATLIAQARVT-HAFVPPSVLATLPGAA 4756 Query: 735 XXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVV 794 + + + VGGEA ++ R++ + N YGPTE V +T V+ Sbjct: 4757 TGELPAFQGLVVGGEACSPDLVRRWSA--GRRMTNLYGPTETTVATT---VSRPLFGEAH 4811 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-G 853 PIG P YVLD LH VP GELY+GG L RGYL R LTA RF+ADPF P G Sbjct: 4812 PIGAPLPGWRVYVLDAGLHLVPPGSRGELYIGGVGLTRGYLRRAGLTASRFVADPFGPAG 4871 Query: 854 MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEET 913 R+YRTGD+VR N GELE++GR+D QV+IRG R+E GEV++ +T HP V +VV + Sbjct: 4872 ARMYRTGDVVRWNADGELEYLGRSDHQVQIRGIRVEPGEVQAALTAHPDVARAVVVVSDD 4931 Query: 914 EAG-PMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALP 972 G P L Y+VP D +R +P+++VP A V+PEIP+T +GKLDR ALP Sbjct: 4932 RRGDPALVGYMVPERPGADPAAVREDLRRILPDHLVPVAIVVLPEIPLTPNGKLDRDALP 4991 Query: 973 APTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAE 1032 P T R REP T E +C +F ++ G ++VGAED FF LGGHSLL RL++ IRA+ Sbjct: 4992 DPE-YETSRGREPRTPEEEILCGLFTEVLGLKQVGAEDDFFDLGGHSLLGTRLISGIRAK 5050 Query: 1033 FGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARP 1092 G ++ + T+F+A TPA LA ++E + P AR RP Sbjct: 5051 LGFEVRLLTLFEASTPAALARAMLEA---------------NAP-----ARTALEPMPRP 5090 Query: 1093 QRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF 1152 + LPLS +Q WF +++EG +NMPL L+ GP RHEALRT F Sbjct: 5091 ELLPLSFAQQRLWFLHKLEGPSPTYNMPLTLQLSGPLDVPALRAALTDVVGRHEALRTVF 5150 Query: 1153 DEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDT 1212 EH+G YQ + ++L V DE + RH F L+ +L GP Sbjct: 5151 AEHDGQAYQRILDPVEIELPVHDAASDEALQAAA---RHRFDLAGEIPLRVSLYAAGPGE 5207 Query: 1213 HVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF--- 1269 VL+L++HHIV+D SL + DL AY AR AP W P+Q+ADY +W R Sbjct: 5208 WVLMLVLHHIVADGWSLRPLARDLATAYAARTAGRAPDWAPPPVQYADYTLWHRELLGDD 5267 Query: 1270 ---ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQL 1326 +S +G+ +L +WRD LA LP+++++ TDR RPRV RG+V F V A A L L Sbjct: 5268 ADPDSAFGR-QLAFWRDRLADLPEQVTLPTDRPRPRVASYRGDVSTFQVDAELHAGLMAL 5326 Query: 1327 AERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDL 1386 A + G+T FM+ Q AL+ +L + G GTD+ +G+ VA R + LVG F N+VVLRTD Sbjct: 5327 ARQTGSTLFMVLQTALSALLTRSGAGTDVVVGAGVAGRTDERLDDLVGFFVNMVVLRTDT 5386 Query: 1387 SGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQ 1434 S DPT +L R + L A AHQ++P E LVE +NP R+ S LFQ Sbjct: 5387 SDDPTFVELLQRVRASSLAAYAHQDIPFEYLVEKINPLRSASHQSLFQ 5434 Score = 743 bits (1918), Expect = 0.0 Identities = 516/1438 (35%), Positives = 725/1438 (50%), Gaps = 101/1438 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 E LS Q+R+WFL ++ T N +A +L+G +D D L A+ DVV RH LRT + Sbjct: 3046 EALPLSFAQQRLWFLHKLEGPSATYNSPLAIKLSGELDVDALRLALADVVVRHEALRTVF 3105 Query: 100 GVDTEGEPYQVFSD--DVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLR 157 + G PYQ D +VE+ R ++LP+A + A EF DL E+PLR Sbjct: 3106 A-ERAGNPYQRILDSAEVELPVREVPQSKLPDA-----LREAARYEF----DLAREIPLR 3155 Query: 158 ITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPIND-PAAQFLSVEVLQNS 216 + E VL+L +HH+ D S +V L+AAY P+ Q L V+ + Sbjct: 3156 AWLFTAGPGEWVLMLALHHVVADGWSLQVLVSNLTAAYTSRRAGHAPSWQPLPVQYADYT 3215 Query: 217 A-------------APSVADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLPA 261 + S V YW E L A R + L A Sbjct: 3216 LWQRRHLGTEDDPDSVSSRQVSYWLEQLADLPDQVTLPTDRPRPAVASYRGETVTFDLDA 3275 Query: 262 GLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSG-AAAGALGYFG 320 + + AR+ + FM+L AA L+ R +D + P+ R+ +G F Sbjct: 3276 EEHAELVRLARETGTTLFMILQAALAGLLTRLGAGTDIAIGSPIAGRTDDRLENLIGLFV 3335 Query: 321 NTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRL 380 N L+LR T T + VRET LA +AHQ + + +V NP R LV++ Sbjct: 3336 NMLVLRTDTGGDPTLGELLTRVRETSLAAYAHQHMPFEYLVERLNPHRSAAHHP--LVQI 3393 Query: 381 GFNMRKSAG-GLALDGVVVRQLGLGAVAAHLPLSLTI--ALDPDDVSVEFEYQQQLSSVL 437 F ++ +A ++L GV + + + + LS+ I A PD + S+ L Sbjct: 3394 LFGLQNTAEQNVSLPGVTASGMSVDTGVSRVDLSINIVEASAPDGSPAGLTGLVEFSTDL 3453 Query: 438 VDQMLVH-----YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVK 492 D+ V +++++ + P LS + +LGA ER +L + + A T+ + Sbjct: 3454 YDRATVEAFAARWVRVLRAMVVAPGSRLSGVQLLGADERVRLLQRWGAASGPVAAVTLAE 3513 Query: 493 XXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 V E +Y+ L+ ANR+A + +G G ED++ + + Sbjct: 3514 LFERRVAARPDAVAV--VEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAV 3571 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPL 612 + +L V+KAGAAYLP+DP+YP R++YL+ DA P VIG E DV + Sbjct: 3572 QVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIG--ESDVFDGQP-------- 3621 Query: 613 SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAED--RWLQ 670 + D +RP+ AYVIYTSGSTG+PKGV V+H +A + + A + R LQ Sbjct: 3622 -EHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLASMA---ATQQRLGAGEGSRVLQ 3677 Query: 671 FSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXX 730 F+++ FDA++ ++ + L GA L+VPK D A L +R Sbjct: 3678 FAALGFDATVWELVMALGAGAALVVPKTDQLAGEDLAAVLREQR-----ITHLTLPPTVL 3732 Query: 731 XXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHG 790 + L + V GEA P E+ R++ + N YGPTE+ VC++ ++ Sbjct: 3733 ATVPADRLPDLGTLVVAGEACPPELTARWSP--GRRMFNAYGPTESTVCAS---ISAELS 3787 Query: 791 ARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF 850 + PIG P N YVLD+ L P V GELY+ G LARGY GR LTA R +ADP+ Sbjct: 3788 PGLAPIGGPVLNTRLYVLDDALQPAASGVPGELYIAGEGLARGYRGRAGLTATRILADPY 3847 Query: 851 NP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVV 909 P G R+YRTGD+VR N G+LE++GR+DEQVKIRGFR+E GEV SV+ HPAV V+ Sbjct: 3848 GPVGSRMYRTGDVVRWNADGDLEYLGRSDEQVKIRGFRVEPGEVASVLLRHPAVAQAAVI 3907 Query: 910 AEETEAGPMLAAYLVPAAAQVDLE-EIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDR 968 + L AY VPA + + E+RA+ +PE+ VP A ++ EIP T GK+D+ Sbjct: 3908 VRLEQ----LLAYAVPALGRAVRDGELRAYLQDELPEHTVPSAVVLLDEIPRTSHGKVDQ 3963 Query: 969 RALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQ 1028 RALP P A R R P T E +C +FAQ+ Q+VG +DSFF LGGHSLLA RL+ + Sbjct: 3964 RALPDPEQ-AGGRGRAPRTPQEELLCVLFAQVLDVQQVGPDDSFFDLGGHSLLATRLIIR 4022 Query: 1029 IRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVK 1088 IR F +L R +F AP+PA LA L E+ R + Sbjct: 4023 IRRAFRCELPPRALFAAPSPAELAVVLSEQ--------------------QGRVQQALEP 4062 Query: 1089 SARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEAL 1148 ARP+ LPLS +Q WF +++EG +N PLALR G RHEAL Sbjct: 4063 VARPEVLPLSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTALRAALGDVVGRHEAL 4122 Query: 1149 RTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVL 1208 RT F E +GVPYQ V V L+VR + DE V R+ F ++A L Sbjct: 4123 RTVFAETDGVPYQKVLDVADVDLSVREVAADELPGVLRDAARYEFDLAREIPVRAWLFAA 4182 Query: 1209 GPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNT 1268 GP VL+L++HHI +D SL + DL AY R P W LP+Q+ADY +WQR Sbjct: 4183 GPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPLPVQYADYTLWQRRL 4242 Query: 1269 F------ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAA 1322 +S +G+ +L YWR LAGLP ++++ TDR RP+ G+V F + A A Sbjct: 4243 LGDEADPDSVFGR-QLAYWRGQLAGLPQQVTLPTDRPRPQTASYAGDVTMFRLDAGLHAD 4301 Query: 1323 LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVL 1382 L +LA +GAT FM+ QAAL VL +LG G D+ LGSP+A R + LVG F N +VL Sbjct: 4302 LLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDGLDDLVGFFVNTLVL 4361 Query: 1383 RTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 R D SG+P +L RDT L+A AHQ++P E LVE LNP R+ + +PLFQ +L F+ Sbjct: 4362 RADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTAHSPLFQVLLAFQ 4419 Score = 592 bits (1526), Expect = e-166 Identities = 378/993 (38%), Positives = 518/993 (52%), Gaps = 57/993 (5%) Query: 517 TYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPD 576 +Y EL+ ANR+A W IG+G GPE +G+ + I+ I A+L LKAGA YLP+DP P Sbjct: 35 SYRELNSAANRIAWWLIGRGVGPEQTVGVALDRGIDQIAALLGTLKAGAVYLPLDPVLPA 94 Query: 577 ERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGST 636 ERI+YL+ DA P ++ A +A D P PL LAYVIYTSGST Sbjct: 95 ERINYLLADATPSLILDGD----AAASAGQPEDTPAV------PLTSDSLAYVIYTSGST 144 Query: 637 GRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVP 696 G PKGV V+H ++ + ++ + R LQ +S+ FD ++ ++ + G L+V Sbjct: 145 GTPKGVGVTHGSMVNLARTVTGQYALGDTPRVLQLASLGFDVAIWELLTAVATGGTLVVS 204 Query: 697 KPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVA 756 + D + L +R V Q L V +GGE P E+ Sbjct: 205 QADQLSGDDLLRVLREQRITHVTLPVPVLASLPPDAEN--QLPDLTTVHIGGETCPPELV 262 Query: 757 DRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVP 816 R++ L N YG TE V +T +T PIG YVLD+ L V Sbjct: 263 RRWSA--GRRLINGYGATETTVAAT---LTPPLTGPDAPIGKAIDGTRVYVLDDTLAQVV 317 Query: 817 DQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVG 875 GELY+ G+ +ARGYL RP LTA RF+ADP+ P G R+YRTGD+ G+LEF+ Sbjct: 318 LGAAGELYVAGANVARGYLRRPGLTASRFLADPYGPPGSRMYRTGDVGLIRPDGQLEFLR 377 Query: 876 RADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGP-MLAAYLVPAAAQVDLEE 934 RAD+QVKIRG R+E GE+E+V+ V H V G L AY+VPAAA E Sbjct: 378 RADDQVKIRGARVEPGELEAVLQRRTDVVHAAVTVRPDARGERQLVAYVVPAAAATGAAE 437 Query: 935 IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWIC 994 +R +P Y+VP + ++ +P+T +GK+DR ALP P R + E + Sbjct: 438 LRDDLRGTLPSYLVPSSVVLLDSLPLTPNGKVDRDALPDPEYAPAGLDRTARSPLEDMLR 497 Query: 995 SIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAAR 1054 +FA++ +VG +D FF LGGHSLLA RL+ +IR G+++ ++ F+ TPA LA+ Sbjct: 498 VVFAEILELPQVGFDDDFFDLGGHSLLAGRLIGRIRGTLGLEVHMKDFFEKSTPAALASY 557 Query: 1055 LVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAR 1114 L + + ARP + RP R+PLS +Q WF +R+EG Sbjct: 558 LQRQ-------------------ETGPARPELTRLPRPDRIPLSFAQQRLWFLHRLEGPS 598 Query: 1115 EEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQ--LA 1172 +NMPLAL G RHE LRT E +G PYQ + V+ L Sbjct: 599 ATYNMPLALHLTGKVDTGALAAALTDVIRRHEPLRTLIREVDGQPYQQILDPEEVRPALP 658 Query: 1173 VRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIV 1232 VR + + D+ + RH F ++A LL + PD VL+L++HHI D S + Sbjct: 659 VRQVGAAQLDEELRRSARHEFDLARQIPVRAELLTVSPDESVLMLVIHHIAGDGWSGAPL 718 Query: 1233 FDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT-----ELDYWRDALAG 1287 DL+ A+ ARL APQW LP+Q+ADY +WQR +L YWR+ LA Sbjct: 719 ARDLVTAHSARLTGVAPQWPPLPVQYADYTLWQRAMLGGEEEPASPLNEQLRYWREQLAD 778 Query: 1288 LPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLH 1347 LP EI+V DR RP V RG VV ++ A A +T+LA RNGAT +M+ Q+ + +L Sbjct: 779 LPHEITVPGDRPRPAVATYRGGVVPITMDADLHAGITELARRNGATVYMVLQSTVTALLT 838 Query: 1348 KLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDAL 1407 +LG GTD+A+G+ VA R EPA LVGLF N++VLRTD +G P +L RDT L A Sbjct: 839 RLGAGTDVAIGAGVAGRSEPALDDLVGLFVNMLVLRTDTAGSPRFTELLQQVRDTSLGAY 898 Query: 1408 AHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTG-RGETTVVPL-PVN 1465 HQ++P E+LVE+LNP R R LFQ L + VP DL G R +P Sbjct: 899 GHQDIPFEQLVESLNPHRVAGRQSLFQVALVLQNN--TSVPFDLPGLRVRAEQIPTGTAR 956 Query: 1466 FEVALLFLAIGMSVTPSGE-LDVQVIANADLYE 1497 F+++L SVT G+ + V ADLY+ Sbjct: 957 FDLSL-------SVTEHGDGISGTVEYAADLYD 982 Score = 519 bits (1337), Expect = e-144 Identities = 367/1073 (34%), Positives = 522/1073 (48%), Gaps = 83/1073 (7%) Query: 27 AEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVN 86 A + + +P + P LS Q+R+WF+Q ++ T N +A RL+G +D + A+ Sbjct: 6470 ALEPAPRPEVLP-----LSFAQQRLWFMQNLEGASATYNSPLAVRLSGALDVAAMRAALG 6524 Query: 87 DVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLP-EAGHERQIESLAADEFG 145 DV+ARH +LRT +G + GEPYQ D VE+ LP A E + + D Sbjct: 6525 DVLARHEVLRTVFG-ERRGEPYQRILDAVEID--------LPVRAVAEGDLTQVLRDASR 6575 Query: 146 RPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-------- 197 FDL+ E+P+R ++ T DE VLLLVVHH+ D S +L+ AY Sbjct: 6576 HEFDLSREIPVRASLFNTGRDEWVLLLVVHHVAVDGWSMRPLTRDLTTAYEQRAAGRVPD 6635 Query: 198 -LPINDPAAQFLSVE--VLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGA--NPC 249 P+ A F + +L + A P + YW + L Sbjct: 6636 WAPLRVQYADFALWQHRMLGDEADPDSRLSRQLAYWRDQLAGLPRLVTLPADRPRPDEAS 6695 Query: 250 RRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERS 309 R R L A L + AR+ ++ FM L AA G + R +D V P+ R+ Sbjct: 6696 HRGAMLTRNLDADLHQALRVLARRHGSTLFMALQAALGAQLSRSGAGTDIPVGAPIAGRA 6755 Query: 310 GAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER 368 A L G+F NTL+LRI T + +FT + +VRET LA +AHQ V D +V + NP+R Sbjct: 6756 DDALEDLVGFFINTLVLRIDTSGRPSFTRLLKQVRETSLAAYAHQDVPFDHLVEKLNPDR 6815 Query: 369 MGRDGMDLLVRLGFNMRKSAGGLALDGVVVR-QL-GLGAVAAHLPLSLTIALDPDD---- 422 V+L A L G+ R QL G+ + + LS+ DD Sbjct: 6816 SPGQHPLFQVQLVLQNTPDAE-FELAGLTARPQLDGVETGVSRVDLSVNAIETFDDHGLP 6874 Query: 423 --VSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSH 479 + + EY L S VD L + QL+ + P++P+ L++ D++ A Sbjct: 6875 AGLILVVEYATDLYDSATVDAFLDEFGQLLHEVADSPDQPIGGLEL------DNIAAPVP 6928 Query: 480 GELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGP 539 G L ++ T A++TY+EL+ RANR+AR I +G GP Sbjct: 6929 GTLPQLFETWAAATPSAIAV----------TDGAADMTYAELNSRANRMARALIDRGAGP 6978 Query: 540 EDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI------- 592 ED++ + + S+ + +LA+ K+GAAYLPIDP YP +R+ YL DA P+ ++ Sbjct: 6979 EDLVAVLLPRSVRQVATILAIAKSGAAYLPIDPTYPADRVAYLCADALPKLIVTDAAGSA 7038 Query: 593 ----GRPELDVAERAAA----DNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAV 644 +P +DV + A D +D DR L H AYVIYTSGSTGRPKG + Sbjct: 7039 RLGADQPVIDVDDPATVAQWESRPDTDPTDRDRTTALGLDHPAYVIYTSGSTGRPKGAVI 7098 Query: 645 SHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDI 704 + +A + +V W R LQ SS SFDAS+ D V L++P+P Sbjct: 7099 TQAGLAGAAEAWVQRWGFEPGSRVLQLSSPSFDASIMDFIVAFAAQGTLVLPEPGLIAGE 7158 Query: 705 SYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFD 764 + L +R + LR + +GGE L ++A R++ Sbjct: 7159 ALARVLTEKR--ITHLVTLPSVLASMPVDVAGRLTGLRGLLLGGEVLTPDLAARWSP--G 7214 Query: 765 AELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELY 824 + N YG TE V T +T V +G P YVLD L VP GELY Sbjct: 7215 RRMINVYGQTETTVACT---MTDPLAGERVTVGRPIPGTRVYVLDALLRVVPPGTDGELY 7271 Query: 825 LGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKI 883 + G + RGYL R LTA RF+ADP+ PG R+YRTGDL R N+ ELE+ GR DEQVKI Sbjct: 7272 VAGPAVGRGYLHRAGLTASRFVADPYGPPGSRMYRTGDLGRLNYAFELEYAGRTDEQVKI 7331 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQVDLEEIRAHTAAA 942 RG R+E GEVE+ + HPAV V G + L Y++P A D+ IR + Sbjct: 7332 RGMRVEPGEVEAALAEHPAVARAAVAVRADRQGDLALFGYVIPVQAGADVSGIREDLRRS 7391 Query: 943 VPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFG 1002 +PE++VP + + P+T +GK+DR ALPAP + R P T E +C +FA+L G Sbjct: 7392 LPEHLVPAVMTAMTDFPLTPNGKVDRDALPAP-QVTAPVGRGPRTPQEEILCGLFAELLG 7450 Query: 1003 RQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 ++G ED+FF LGGHSLLA +L+A+I G ++ +RT F PT A LA +L Sbjct: 7451 LGQIGVEDNFFDLGGHSLLANKLIARIAEVMGTEIPIRTFFAGPTVAQLAEQL 7503 Score = 397 bits (1019), Expect = e-108 Identities = 301/934 (32%), Positives = 440/934 (47%), Gaps = 76/934 (8%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS Q+R+WFL ++ T N+ +A L G VD L A+ DV+ RH LRT Sbjct: 577 DRIPLSFAQQRLWFLHRLEGPSATYNMPLALHLTGKVDTGALAAALTDVIRRHEPLRTLI 636 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGR-----PFDLTNEL 154 + +G+PYQ D EV LP RQ+ + DE R FDL ++ Sbjct: 637 R-EVDGQPYQQILDPEEVR------PALPV----RQVGAAQLDEELRRSARHEFDLARQI 685 Query: 155 PLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDP 203 P+R ++ DE VL+LV+HHI D S +L A++ LP+ Sbjct: 686 PVRAELLTVSPDESVLMLVIHHIAGDGWSGAPLARDLVTAHSARLTGVAPQWPPLPVQYA 745 Query: 204 AAQFLSVEVL---QNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLP 260 +L + A+P + YW E L G + V P+ Sbjct: 746 DYTLWQRAMLGGEEEPASPLNEQLRYWREQLADLPHEITVPGDRPRPAVATYRGGVVPIT 805 Query: 261 --AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-G 317 A L + + + AR+ A+ +MVL + L+ R +D + V RS A L G Sbjct: 806 MDADLHAGITELARRNGATVYMVLQSTVTALLTRLGAGTDVAIGAGVAGRSEPALDDLVG 865 Query: 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLL 377 F N L+LR T FT + +VR+T L + HQ + +++V NP R+ G L Sbjct: 866 LFVNMLVLRTDTAGSPRFTELLQQVRDTSLGAYGHQDIPFEQLVESLNPHRVA--GRQSL 923 Query: 378 VRLGFNMRKSAG-GLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SS 435 ++ ++ + L G+ VR + A LSL++ D +S EY L Sbjct: 924 FQVALVLQNNTSVPFDLPGLRVRAEQIPTGTARFDLSLSVTEHGDGISGTVEYAADLYDR 983 Query: 436 VLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 + ++ ++QL+ + +A+P R + +LD+ G+ + E P T Sbjct: 984 ATAEAVVERWIQLIRQVVADPARRVDTLDVTTPGDESRLAGWRRYERDVPPVT----FGD 1039 Query: 496 XXXXXXXXXXXXXXVSDEAEL-TYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFI 554 VSD ++ TY E++R AN +A I +G GPED + + M S + Sbjct: 1040 LFARQVAATPDAIAVSDGGDVWTYREVNRYANHVADRLIDRGIGPEDFVAVAMPRSARLV 1099 Query: 555 VAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADN--SDLPL 612 ++L VLKAGAAY+P+D +P R ++I D+ P+ V+ RA A+N +DLP Sbjct: 1100 ASLLGVLKAGAAYVPVDLVFPARRNRHVIIDSNPRLVL-------TSRAGAENLPADLPC 1152 Query: 613 ----------------SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 +D+DR+RP AYVIYTSGSTG+PKGV V+H +A + Sbjct: 1153 ELVMIDAWGTGREDGPADADRVRPSNVDSPAYVIYTSGSTGQPKGVVVTHRGLAAFAETL 1212 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGV 716 DR LQ SS S DAS+ ++ GA+L++ L +R Sbjct: 1213 RERCAAGPNDRVLQLSSPSVDASVLEMVWAFSSGARLVIASQYRLAGEELAQALAEQR-- 1270 Query: 717 TVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEA 776 + + R + VG E+ P E+ + + N YGPTE Sbjct: 1271 ITHAHIPPSALSTIPAEAAGRLPEFRRLSVGAESCPSELVRLWLP--GRDFVNAYGPTEC 1328 Query: 777 VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLG 836 V ++H A PIG P + YVLDE L P V GELY+GG+ LARGYL Sbjct: 1329 TVAASHTFPLAEARA---PIGRPVIDAELYVLDETLRPAAPGVPGELYIGGAGLARGYLR 1385 Query: 837 RPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVES 895 R LTA RF+A+P+ PG R+YRTGD+VR N GELE++GR+DEQVK+RGFR+E GEVE Sbjct: 1386 RGGLTASRFVANPYGEPGSRVYRTGDVVRWNTDGELEYLGRSDEQVKVRGFRVEPGEVER 1445 Query: 896 VITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAA 928 V+ + P+V +VV +G + LAAY+V AAA Sbjct: 1446 VLASQPSVDRAVVVPRRDRSGAVSLAAYVVLAAA 1479 Score = 372 bits (955), Expect = e-100 Identities = 294/919 (31%), Positives = 431/919 (46%), Gaps = 78/919 (8%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++ T N+ + +L+G +D L A+ DVV RH LRT + + Sbjct: 5095 LSFAQQRLWFLHKLEGPSPTYNMPLTLQLSGPLDVPALRAALTDVVGRHEALRTVF-AEH 5153 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLP--EAGHERQIESLAADEFGRPFDLTNELPLRITVI 161 +G+ YQ D VE+ LP +A + +++ A FDL E+PLR+++ Sbjct: 5154 DGQAYQRILDPVEI--------ELPVHDAASDEALQAAARHR----FDLAGEIPLRVSLY 5201 Query: 162 RTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPIN------DPAAQFLSV----- 210 E VL+LV+HHI D S +L+ AY P Q+ Sbjct: 5202 AAGPGEWVLMLVLHHIVADGWSLRPLARDLATAYAARTAGRAPDWAPPPVQYADYTLWHR 5261 Query: 211 EVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---------P 258 E+L + A P A + +W + L P R + RV Sbjct: 5262 ELLGDDADPDSAFGRQLAFWRDRLADLPEQVTL-------PTDRPRPRVASYRGDVSTFQ 5314 Query: 259 LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-G 317 + A L + + AR+ ++ FMVL A L+ R +D +V V R+ L G Sbjct: 5315 VDAELHAGLMALARQTGSTLFMVLQTALSALLTRSGAGTDVVVGAGVAGRTDERLDDLVG 5374 Query: 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLL 377 +F N ++LR T TF + VR + LA +AHQ + + +V + NP R L Sbjct: 5375 FFVNMVVLRTDTSDDPTFVELLQRVRASSLAAYAHQDIPFEYLVEKINPLRSA--SHQSL 5432 Query: 378 VRLGFNMRKSA-GGLALDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVSVEFEYQ 430 ++ ++ +A L GV V Q G G + LSL++ P V+ E+ Sbjct: 5433 FQIAMVLQNNAEADFDLSGVRVWQEGRGTGTSRFDLSLSLTETTTADGRPTGVTGVVEFS 5492 Query: 431 QQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATT 489 L V+ +++++ + P LS + +LGA ER +L + + A T Sbjct: 5493 TDLYDRATVEAFAARWVRVLRAMVVAPGSRLSGVQLLGADERVRLLQRWGAASGPVAAVT 5552 Query: 490 MVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMAN 549 + + V E +Y+ L+ ANR+A + +G G ED++ + + Sbjct: 5553 LAE--LFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPR 5610 Query: 550 SIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSD 609 + +L V+KAGAAYLP+DP+YP R++YL+ DA P VIG E DV + Sbjct: 5611 GAVQVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIG--ESDVFDGQ------ 5662 Query: 610 LPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWL 669 + D +RP+ AYVIYTSGSTG+PKGV V+H ++ + R L Sbjct: 5663 ---PEHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLSGLAATLRQRCAADVDSRIL 5719 Query: 670 QFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXX 729 Q SS SFDA++ ++ GA L++ D L R Sbjct: 5720 QASSPSFDAAVLELVWAWDSGAALVIASADRLAGDELARALADHR--ITHALIPPSVLST 5777 Query: 730 XXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSH 789 R + VG EA P E+ R+A + N YGPTEA V ++ TG Sbjct: 5778 LAADAPRTLTDFRTLIVGAEACPPELLRRWAP--GRRMVNAYGPTEATVVASQ---TGEL 5832 Query: 790 GARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADP 849 V IG P YVLDE+L V GELY+ G+ +ARGY RP+LTA RF+ADP Sbjct: 5833 HEPPVSIGKPALGTRLYVLDERLGLAAPGVPGELYIAGAGVARGYRTRPSLTASRFLADP 5892 Query: 850 FNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLV 908 + P G R+YRTGDLVR N G+LE++GR+DEQVKIRGFR+E GEVE V+ P+V +V Sbjct: 5893 YGPAGTRMYRTGDLVRWNADGDLEYLGRSDEQVKIRGFRVEPGEVERVLAAQPSVARAVV 5952 Query: 909 VAEETEAGPM-LAAYLVPA 926 V +G + LAAY+V A Sbjct: 5953 VPRPDRSGAVSLAAYVVLA 5971 Score = 365 bits (936), Expect = 4e-98 Identities = 218/552 (39%), Positives = 298/552 (53%), Gaps = 40/552 (7%) Query: 907 LVVAEETEAGPMLAAYL---------VPAAAQVD---LEEIRAHTAAAVPEYMVPGAFAV 954 +V+ EA P+ Y VP A+ + E+R+ +P+YMVP Sbjct: 1820 VVLIHAAEAEPLADVYRPADGVEPANVPEVARTAGKLVSELRSTVQGLLPDYMVPATITP 1879 Query: 955 IPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFG 1014 I IP+T +GK+DRRALP P + +R R T E+ +C ++A + G +RVG +DSFF Sbjct: 1880 IERIPVTPNGKIDRRALPDPEVVLSRG-RHARTPLEQILCELYADILGLERVGVDDSFFD 1938 Query: 1015 LGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADD 1074 GGHSLLA RL ++IR+ GV+ ++ +F AP+PA LA L E+ Sbjct: 1939 RGGHSLLATRLTSRIRSVLGVEALLQQVFAAPSPAELAVVLSEQ---------------- 1982 Query: 1075 MPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXX 1134 R + ARP+ LPLS +Q WF +++EG +N PLALR G Sbjct: 1983 ----QGRVQQALEPVARPEVLPLSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTAL 2038 Query: 1135 XXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFT 1194 RHEALRT F E +GVPYQ V V L+VR + DE V R+ F Sbjct: 2039 RAALGDVVGRHEALRTVFAETDGVPYQKVLDVADVDLSVREVAADELPGVLRDAARYEFD 2098 Query: 1195 PESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDIL 1254 ++A L GP VL+L++HHI +D SL + DL AY R P W L Sbjct: 2099 LAREIPVRAWLFAAGPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPL 2158 Query: 1255 PIQFADYAVWQRNTF------ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRG 1308 P+Q+ADY +WQR +S +G+ +L YWR LAGLP ++++ TDR RP+ G Sbjct: 2159 PVQYADYTLWQRRLLGDEADPDSVFGR-QLAYWRGQLAGLPQQVTLPTDRPRPQTASYAG 2217 Query: 1309 EVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPA 1368 +V F + A A L +LA +GAT FM+ QAAL VL +LG G D+ LGSP+A R + Sbjct: 2218 DVTMFRLDAGLHADLLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDG 2277 Query: 1369 TAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALS 1428 LVG F N +VLR D SG+P +L RDT L+A AHQ++P E LVE LNP R+ + Sbjct: 2278 LDDLVGFFVNTLVLRADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTA 2337 Query: 1429 RNPLFQNMLNFR 1440 +PLFQ +L F+ Sbjct: 2338 HSPLFQVLLAFQ 2349 Score = 342 bits (877), Expect = 3e-91 Identities = 208/547 (38%), Positives = 283/547 (51%), Gaps = 36/547 (6%) Query: 907 LVVAEETEA-------GPMLAAYLVPAAAQV---DLEEIRAHTAAAVPEYMVPGAFAVIP 956 L+ A+E EA G VPA A+ + E+R + +P++MVP I Sbjct: 6301 LLAADEDEALTDVYRPGTPEVVANVPAVARTAGEHVSELRGTIKSLLPDHMVPATITPIE 6360 Query: 957 EIPMTVSGKLDRRALPAPTPIATR-RYREPETATERWICSIFAQLFGRQRVGAEDSFFGL 1015 IP+T +GK+DRRALP P + T R P E +C ++A L G RVG ++SFF L Sbjct: 6361 RIPLTPNGKIDRRALPEPEIVTTTTEERGPRDPYEEILCELYADLLGLPRVGVDESFFDL 6420 Query: 1016 GGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDM 1075 GGHSLLA RL ++IRA G+++ ++ +F A TPA LAA L + Sbjct: 6421 GGHSLLATRLTSRIRAVLGIEVPLQQVFAASTPAQLAAVLAQ------------------ 6462 Query: 1076 PLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXX 1135 RA P + RP+ LPLS +Q WF +EGA +N PLA+R G Sbjct: 6463 --GSGRAGPALEPAPRPEVLPLSFAQQRLWFMQNLEGASATYNSPLAVRLSGALDVAAMR 6520 Query: 1136 XXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTP 1195 RHE LRT F E G PYQ + + + L VRA+ + + V RH F Sbjct: 6521 AALGDVLARHEVLRTVFGERRGEPYQRILDAVEIDLPVRAVAEGDLTQVLRDASRHEFDL 6580 Query: 1196 ESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILP 1255 ++A+L G D VLLL+VHH+ D S+ + DL AY R P W L Sbjct: 6581 SREIPVRASLFNTGRDEWVLLLVVHHVAVDGWSMRPLTRDLTTAYEQRAAGRVPDWAPLR 6640 Query: 1256 IQFADYAVWQRNTFESNWG-----QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEV 1310 +Q+AD+A+WQ +L YWRD LAGLP +++ DR RP RG + Sbjct: 6641 VQYADFALWQHRMLGDEADPDSRLSRQLAYWRDQLAGLPRLVTLPADRPRPDEASHRGAM 6700 Query: 1311 VQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATA 1370 + ++ A AL LA R+G+T FM QAAL L + G GTDI +G+P+A R + A Sbjct: 6701 LTRNLDADLHQALRVLARRHGSTLFMALQAALGAQLSRSGAGTDIPVGAPIAGRADDALE 6760 Query: 1371 QLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRN 1430 LVG F N +VLR D SG P+ +L R+T L A AHQ++P + LVE LNP R+ ++ Sbjct: 6761 DLVGFFINTLVLRIDTSGRPSFTRLLKQVRETSLAAYAHQDVPFDHLVEKLNPDRSPGQH 6820 Query: 1431 PLFQNML 1437 PLFQ L Sbjct: 6821 PLFQVQL 6827 Score = 47.8 bits (112), Expect = 0.014 Identities = 29/89 (32%), Positives = 47/89 (52%), Gaps = 1/89 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTIA 1618 E L + +LL + + DE++F LGG S++A + +++ A LG+ P VF T A Sbjct: 6395 EEILCELYADLLGLPRVGVDESFFDLGGHSLLATRLTSRIRAVLGIEVPLQQVFAASTPA 6454 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 +LAA + +G +P P E P+S Sbjct: 6455 QLAAVLAQGSGRAGPALEPAPRPEVLPLS 6483 Score = 38.5 bits (88), Expect = 8.3 Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 1/89 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTIA 1618 E L + E+L + + ++++F LGG S++ + S LG +FE T A Sbjct: 5008 EEILCGLFTEVLGLKQVGAEDDFFDLGGHSLLGTRLISGIRAKLGFEVRLLTLFEASTPA 5067 Query: 1619 ELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 LA A+ AN +P P E P+S Sbjct: 5068 ALARAMLEANAPARTALEPMPRPELLPLS 5096 >tr|A4FHN2|A4FHN2_SACEN Tax_Id=405948 SubName: Full=Putative non-ribosomal peptide synthetase;[Saccharopolyspora erythraea] Length = 7259 Score = 779 bits (2011), Expect = 0.0 Identities = 538/1445 (37%), Positives = 733/1445 (50%), Gaps = 101/1445 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS QRR+WFL M+ NI + RL+G +D L A DVV+RH LRT + Sbjct: 4709 DRVPLSFAQRRLWFLHRMEGPSPAYNIPLVLRLSGELDVRALRGAFGDVVSRHDSLRTLF 4768 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +T+G P+QV D R LP + D FDL +ELP+R T Sbjct: 4769 A-ETDGVPHQVVVD------REAPFAVLPPS------PGGLVDAARYCFDLASELPVRAT 4815 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDP-AAQFLSVEVL 213 + LL+++HHI D S E +L++AY P +P A Q+ Sbjct: 4816 LFGEDDQRHTLLVLLHHIAADGGSTEPLLRDLASAYAARVGGGAPDWEPLAVQYADYTAW 4875 Query: 214 QNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLP------------- 260 Q+ S D G A T + G+ P R RP P Sbjct: 4876 QHELLGSEDDPGSLAST-QVEFWCDRLAGL----PDRLELPTDRPRPTIASHRGGAVDVR 4930 Query: 261 --AGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-G 317 A L + V + AR + FMVL A ++ R +D + PV RS AA L G Sbjct: 4931 FDAELHAAVTELARSRGVTVFMVLQAGLAAVLSRLGAGTDVPIGTPVAGRSDAALEELVG 4990 Query: 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLL 377 +F N L+LR +F + VRET LA +AHQ V +R+V NP R Sbjct: 4991 FFVNNLVLRNDVSGDPSFAELLERVRETNLAAYAHQDVPFERLVEVLNPARSLSHHPLFQ 5050 Query: 378 VRLGFNMRKSAGGLALDGVVVRQLGL--GAVAAHLPLSLTIALDPDDVSVEFEYQQQLSS 435 V + + A L + G+ GL G+V L L L D D E + S+ Sbjct: 5051 VMMTVH-DAGAHDLGMPGLHAEVEGLDTGSVTMDLSLELRETSDSDGNPAGIEGDLEFSA 5109 Query: 436 VL-----VDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTM 490 L V++++ + +L+ +A+A P RP+S+L+IL E++ A + +P T Sbjct: 5110 DLFDARTVEELVERFRRLLAEAVAGPGRPVSALEILAPAEKERFAAWNDTRR-PVPEATF 5168 Query: 491 VKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANS 550 V+ V+ ELTY EL RR+N LA + G PE I+ + + + Sbjct: 5169 VELFEARVRERPGATAI--VTASRELTYGELDRRSNALAHRLLDCGAAPETIVAVALPRT 5226 Query: 551 IEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDL 610 E +VA+LAV KAGAAYLP+DP +P ER+ ++++DA P ++ D R A S Sbjct: 5227 PELLVALLAVAKAGAAYLPVDPGHPAERLAHILSDAGPAILV----CDEGSRVPAPESTR 5282 Query: 611 PLSDSDRLRPLRPG------HLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTA 664 + D R P LAYVIYTSGSTGRPKGV VS + + + + Sbjct: 5283 RVLVGDEERADAPSAVRDGRQLAYVIYTSGSTGRPKGVQVSRAGLDNFLASMHEDAGLAQ 5342 Query: 665 EDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXX 724 ++R L ++VSFD + ++++ L GA +++ DA D + +LI R GV Sbjct: 5343 DERMLAVTTVSFDIAALELYLPLVSGATVVLADEDAVRDPRALGELIERAGVG-HVQATP 5401 Query: 725 XXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMV 784 + R LR + VGGEALP +A R + N YGPTE + S Sbjct: 5402 SLWQSLVSEVPERVRGLRML-VGGEALPAALAGRMLE-LGGRVTNLYGPTETTIWSAAAT 5459 Query: 785 VTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQR 844 VTG G V PIG P N +VLD L PVP V+GELY+GG +ARGY RP LTA+R Sbjct: 5460 VTG--GGEVPPIGGPIANTAVHVLDAALRPVPPGVVGELYIGGRGVARGYANRPGLTAER 5517 Query: 845 FIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAV 903 F+ADPF PG R+YRTGDL R G LE+V R D+QVK+RGFRIELGE+E+ + HP V Sbjct: 5518 FVADPFGAPGERMYRTGDLARWRRDGRLEYVARVDDQVKVRGFRIELGEIEACLAAHPRV 5577 Query: 904 RHCLVVAEETEAGPMLAAYLVPAAAQV-DLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTV 962 + + AY V AA +V D +R +PEYMVP AF V+ E+P+T Sbjct: 5578 AQAAAAVRGADEDKRIVAYAVAAAGEVVDSGALRDRARKHLPEYMVPSAFVVLDELPLTP 5637 Query: 963 SGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLA 1022 +GKLDR+ALP P T R P ER +C++F ++ G VG +D FF LGGHSLLA Sbjct: 5638 NGKLDRKALPDPDFSGTGR--APRDERERVLCAMFGEVLGVDGVGIDDGFFELGGHSLLA 5695 Query: 1023 ARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRA 1082 RLV+++R E GV+L VR +F PT AGLA L AA A Sbjct: 5696 TRLVSRVRGELGVELPVRELFVNPTVAGLAGTLD--------------AAGG-------A 5734 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 R G RP R+PLS +Q WF +R+EG +NMP LR G Sbjct: 5735 RRGPAPGPRPARVPLSFAQYRLWFLHRLEGPSATYNMPFVLRLSGELDVPALEAALNDVV 5794 Query: 1143 XRHEALRTNFDEHEGVPYQIV-HPSRT-VQLAVRAIDQDEFDDVSTQLRRHVFTPESGPL 1200 RHE+LRT F + +G PYQ+V P+ V AV A D + +++ R + P+ Sbjct: 5795 GRHESLRTVFPDSDGTPYQLVLDPAEARVDFAVGAGDPEA--ELAEAARAAIEIGTELPI 5852 Query: 1201 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD 1260 +A L G H LLL++HHI D S + DL AY AR++ AP+W LP+Q+AD Sbjct: 5853 -RAALWSAGAQEHTLLLLLHHIAGDGWSQGPLLRDLSEAYAARIRGEAPRWTPLPVQYAD 5911 Query: 1261 YAVWQRNTFESNWGQT-----ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSV 1315 YA+WQR+ S E+ +WR ALAGLP+ + TD RP V RG++++F+ Sbjct: 5912 YALWQRDVLGSEDDPASVLAGEIGFWRSALAGLPERTELPTDHPRPAVASHRGDLLEFTF 5971 Query: 1316 PAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGL 1375 AA+T+LA G T FM+ QA LA +L KLG G D+ +G+PVA R +PA LVG Sbjct: 5972 GTELHAAVTELARSRGTTVFMVLQAGLAALLSKLGAGGDVPIGTPVAGRTDPALDDLVGF 6031 Query: 1376 FANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQN 1435 F N +VLR D+SG+PT +L R T A AHQ++P ERLVE LNP R+LS +PLFQ Sbjct: 6032 FVNNLVLRNDVSGNPTFAELLDRVRQTNAAAYAHQQVPFERLVEVLNPARSLSHHPLFQV 6091 Query: 1436 MLNFR 1440 +L+ + Sbjct: 6092 LLDLQ 6096 Score = 773 bits (1997), Expect = 0.0 Identities = 533/1452 (36%), Positives = 738/1452 (50%), Gaps = 92/1452 (6%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q R+WFL ++ D T + RL+G +D D L A+ DVVARH LRT Y +T Sbjct: 2233 LSFAQWRLWFLHELEDDSATYTEPLLLRLSGELDTDALRAAIGDVVARHETLRTVYP-ET 2291 Query: 104 EGEPYQVF----SDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G P+QV S EV + R D L E H R + + FDL+ ELPLR+ Sbjct: 2292 DGTPHQVVLPPESSVPEVEFVRTDEDGLAE--HLRDLGRYS-------FDLSTELPLRVC 2342 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA-AQFLSVEVL 213 + E LLL++HHI D S +LSAAY + P P Q+ + Sbjct: 2343 LFWLGEREHALLLLLHHIASDGWSDAPLSRDLSAAYAARLRGEAPGWAPLPVQYADYALW 2402 Query: 214 QNSAAPSVADVG--------YWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAG 262 Q S D G +W++ L P + R +PA Sbjct: 2403 QRELLGSETDPGSLVSKQLAFWSQNLAGLPERLELP-TDRPRPAVASYRGSEVEFAIPAD 2461 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 L + + AR+ + FMV+ AA L+ R D + + RS A L G+F N Sbjct: 2462 LHRGLVELARQTGTTLFMVVQAALSALLTRMGAGHDIPLGSVIAGRSDEALEELVGFFVN 2521 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLG 381 TL+LR T + TF V VR LA +AHQ V +R+V NP R V + Sbjct: 2522 TLVLRTDTSGRPTFRELVGRVRRNDLAAYAHQDVPFERLVEVLNPPRSMAHHPLFQVMVL 2581 Query: 382 FNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVSVEFEYQQQL-S 434 F A L L G+ +G+ ++ L D P ++ EY L Sbjct: 2582 FQNNAEAE-LDLPGLRASFHDIGSGSSKFDLDFDFREDYAADGTPLGMAGLIEYATDLFD 2640 Query: 435 SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA---QSHGELVEMPATTMV 491 V M ++L+D +A+P+RP+ +D+L A ER +++ + E +PA Sbjct: 2641 RDTVAAMGQRLVRLLDAVVADPDRPVDDIDLLSAAERRALMPTVRDADTEARTIPALFAE 2700 Query: 492 KXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSI 551 + V ++ LTY+EL RANRLAR + +G G E ++ L + S Sbjct: 2701 QVRRTPDATAL-------VFEDQRLTYAELDARANRLARALVERGAGAERVVALALPRSA 2753 Query: 552 EFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI--GRPELDV-AERAAADNS 608 E +VA+LAVLKAGA YLP+DP YP +RI +++ DA P V+ ELD ER D+ Sbjct: 2754 ELVVALLAVLKAGATYLPVDPGYPADRIAFMLADAAPAVVVTDSATELDTEVERLVLDHL 2813 Query: 609 DLPLSDSDRLRPLR-PGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDR 667 DL D++ L + P + AY+IYTSGSTGRPKGV V H + + + +D Sbjct: 2814 DLSGYDANDLGEMAGPDNAAYIIYTSGSTGRPKGVVVPHRNVHRLLTATGHWFGFGGDDV 2873 Query: 668 WLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXX 727 W F S +FD S+ +++ L G +L+V +L+ R GVTV Sbjct: 2874 WTLFHSYAFDFSVWELWGPLLHGGRLVVVPHVVSRSPKEFLELLVREGVTVLNQTPSAFY 2933 Query: 728 XXXXXXXXX----QWRQLRHVPVGGEAL-PGEVADRFAGYF--DAELRNHYGPTEAVVCS 780 LRHV GGEAL P ++ D + + L N YG TE V Sbjct: 2934 QLAQADRENPEVGDRLALRHVVFGGEALEPSKLDDWYRRHAPDSPRLVNMYGITETTVHV 2993 Query: 781 THMVVTGSHGARV-VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPT 839 T+ + +H A PIG ++ YVLD L PVP V GEL++ G+ LARGYLGR Sbjct: 2994 TYFPLEAAHTADPRSPIGEGIPDLGLYVLDNSLRPVPPGVPGELHVSGAGLARGYLGRAG 3053 Query: 840 LTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVIT 898 L+AQRF+ADPF PG R+YRTGDLVR N G LE++GRAD+QVKIRGFRIELGE+E+ + Sbjct: 3054 LSAQRFVADPFGAPGTRMYRTGDLVRWNGRGVLEYLGRADDQVKIRGFRIELGEIEARVL 3113 Query: 899 THPAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEI 958 +HPAV VV E + G V +A ++D E+R H A++P+YMVP A + + Sbjct: 3114 SHPAVEQAAVVVREDKPGDKRLVGYVVSAEEIDPAEVRRHVGASLPDYMVPVAVVRLESL 3173 Query: 959 PMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGH 1018 P+T +GKLDR+ALPAP R P E+ +C +F + VG +DSFF LGGH Sbjct: 3174 PLTANGKLDRKALPAPDLSVLAGGRAPRNQREKILCGLFGDVLEVPGVGIDDSFFDLGGH 3233 Query: 1019 SLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLD 1078 SLL RLV++IR+ FG +L +R +F+ PT AGLA RL AD Sbjct: 3234 SLLVTRLVSRIRSAFGAELPLRALFETPTVAGLAERLD--------------GADG---- 3275 Query: 1079 PKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXX 1138 AR RP+RLPLS Q WF R+EG +N+PL LR G Sbjct: 3276 ---ARVALRPMPRPERLPLSFVQEGLWFLSRLEGPSATYNVPLVLRLTGELDVDALRAAF 3332 Query: 1139 XXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDE--FDDVSTQLRRHVFTPE 1196 +HE+LRT F EH G P+Q+V P + + +D DE + + RH F Sbjct: 3333 ADVVAQHESLRTLFPEHGGAPHQVVLPPEQARPVLEVVDVDEAAVGEALREASRHHFDIA 3392 Query: 1197 SGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPI 1256 + ++A L LG D H LL ++HHIVSD S ++ +DL AY ARL+ AP ++ LP+ Sbjct: 3393 TELPIRAWLFRLGGDRHALLPLMHHIVSDGWSESLLGNDLATAYAARLRGEAPVFEPLPV 3452 Query: 1257 QFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV 1311 Q+ADY +WQR S + ++ +W +AL GLP++I + TD P G+ Sbjct: 3453 QYADYTLWQRELLGSVDDPGSAISRQMAFWAEALRGLPEKIELPTDHPSPAAATYLGDEA 3512 Query: 1312 QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQ 1371 + A A+ ++A T+FM+ QA +A +L ++G GTDI +G+PVA R + A Sbjct: 3513 PLRLDAELHRAVDEVARATNTTQFMVIQAGVAALLTRMGAGTDIPIGTPVAGRTDEALED 3572 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 L G F N +V+RT GDPT R +L R+T L A AHQ++P ER+VEA+NP R+LS +P Sbjct: 3573 LFGFFVNTLVMRTRTHGDPTFRELLERVRETDLAAFAHQDVPFERIVEAVNPVRSLSHHP 3632 Query: 1432 LFQNMLNFRGED 1443 LFQ ML F D Sbjct: 3633 LFQVMLTFENFD 3644 Score = 618 bits (1594), Expect = e-174 Identities = 384/944 (40%), Positives = 515/944 (54%), Gaps = 45/944 (4%) Query: 511 SDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPI 570 S+ LTY EL RA+RLAR G G P D++ L + + E +V++LAVLK GAAYLP+ Sbjct: 34 SEGPPLTYGELDERASRLARRLAGLGVRPGDVVALALPRTPELVVSLLAVLKTGAAYLPV 93 Query: 571 DPAYPDERIDYLITDARPQTVIGRPE----LDVAERAAADNSDLPLSDSDRLRPLRPG-- 624 DP YP ERI +++ DARP V+ E L AE A +L +SD PL Sbjct: 94 DPDYPAERIAFMLADARPALVLTTGEIAAGLPSAEATVALVEELASDESDVDAPLAGATA 153 Query: 625 -HLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADI 683 H AYVIYTSGSTGRPKGV V H + H+ + A+DR L +++SFDA+ +I Sbjct: 154 RHPAYVIYTSGSTGRPKGVVVPHEGVVNHMLWQAETCGLRADDRVLARTAISFDAAGTEI 213 Query: 684 FVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRH 743 ++ L +GA L + D D + D + R VTV + LR Sbjct: 214 WLPLVVGATLCLASADVVRDPERLIDFVDRHRVTVAQFVPSLLAVAADVDLGERSPALRL 273 Query: 744 VPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNV 803 V V GE LP +A R + L + YGPTEA + TH + G+R +PIG P N Sbjct: 274 VFVAGEVLPPALAARVVRSWGVRLAHLYGPTEASIDVTHWDYDPAIGSRPLPIGRPLWNT 333 Query: 804 YAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDL 862 +VLDE+L PV G+LY+ G QLA GYL RP LTA+RF ADPF PG R+YRTGDL Sbjct: 334 RVHVLDERLRPVAPGEQGDLYVAGVQLAHGYLRRPGLTAERFPADPFGAPGERMYRTGDL 393 Query: 863 VRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAY 922 R N ELEF+GRAD+QVKIRGFRIELGE+ESV+ V V ET AG Sbjct: 394 ARWNGA-ELEFLGRADDQVKIRGFRIELGEIESVLAGFAEVAQAAVTVRETPAGERAIVA 452 Query: 923 LVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRY 982 V V ++ +R+ AAA+PE+MVP +FAVI +P+ +GK+DRR+LP P A Sbjct: 453 HVVLREPVGVQALRSRAAAALPEHMVPASFAVIDRMPLAPNGKVDRRSLPDPWSGADAG- 511 Query: 983 REPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTI 1042 + P T E +C +FA+ G RVG +D FF LGGHSLLA RLV IR+ V+++VR + Sbjct: 512 QAPRTEREAALCELFAEALGVARVGVDDGFFELGGHSLLATRLVRSIRSGMRVEVSVRDV 571 Query: 1043 FDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQR--LPLSHS 1100 F+APT A LA RL R +SA+PQ LS + Sbjct: 572 FEAPTVAALAERLAGAER-------------------------LAESAQPQAGVAELSAA 606 Query: 1101 QLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPY 1160 Q+ W +R+EG +N+PL +R +GP RHE LRT F E +G P Sbjct: 607 QMGLWSLHRLEGPSATYNIPLVVRIDGPLERPALRQAVQDVAVRHETLRTTFPEDDGSPR 666 Query: 1161 QIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVH 1220 + + ++ V ++ + + + RH F + + ++ GP HV+LL++H Sbjct: 667 PRL---ASTEVDVEFVEAADVEAELVRQARHPFDLLNEIPFRVCVVSSGPREHVVLLLMH 723 Query: 1221 HIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT---- 1276 HI +D S + DL AYRARL +AP+W LP +A R + T Sbjct: 724 HIAADGWSERPLVADLSAAYRARLDGHAPRWVELPTGYAAEMRRVRAALGAEDDPTSPLS 783 Query: 1277 -ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEF 1335 ++ +W+D LA LP + + TD RP RG+V++ + A AL LA G T F Sbjct: 784 RQIRFWQDELADLPGLVELPTDHPRPASASHRGDVLRVRMDAELHRALAGLARSTGTTPF 843 Query: 1336 MLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSI 1395 M+ AALA ++ +LG G DI LG+PVA R +VG F N +VLRT GDPT R + Sbjct: 844 MVVHAALAALMTRLGAGADIPLGTPVAGRGSSDVDDVVGYFVNTLVLRTRTQGDPTFREL 903 Query: 1396 LVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 L R+T L A AHQ++P +R+VEA+NP R+LS +PLFQ ML F Sbjct: 904 LARVRETDLAAFAHQDVPFDRVVEAVNPARSLSHHPLFQVMLTF 947 Score = 503 bits (1296), Expect = e-140 Identities = 444/1414 (31%), Positives = 642/1414 (45%), Gaps = 136/1414 (9%) Query: 34 PGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHA 93 PG P R LS Q R+WFL ++ T N+ RL+G +D L A+NDVV RH Sbjct: 5740 PGPRPA-RVPLSFAQYRLWFLHRLEGPSATYNMPFVLRLSGELDVPALEAALNDVVGRHE 5798 Query: 94 ILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNE 153 LRT + D++G PYQ+ D E R+ A E+ A+ ++ E Sbjct: 5799 SLRTVFP-DSDGTPYQLVLDPAEA--------RVDFAVGAGDPEAELAEAARAAIEIGTE 5849 Query: 154 LPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPIND 202 LP+R + A E LLL++HHI D S +LS AY LP+ Sbjct: 5850 LPIRAALWSAGAQEHTLLLLLHHIAGDGWSQGPLLRDLSEAYAARIRGEAPRWTPLPVQY 5909 Query: 203 PAAQFLSVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVR 257 +VL + P+ ++G+W L A R Sbjct: 5910 ADYALWQRDVLGSEDDPASVLAGEIGFWRSALAGLPERTELPTDHPRPAVASHRGDLLEF 5969 Query: 258 PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL- 316 L + V + AR + FMVL A L+ + D + PV R+ A L Sbjct: 5970 TFGTELHAAVTELARSRGTTVFMVLQAGLAALLSKLGAGGDVPIGTPVAGRTDPALDDLV 6029 Query: 317 GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDL 376 G+F N L+LR TF ++ VR+T A +AHQ V +R+V NP R Sbjct: 6030 GFFVNNLVLRNDVSGNPTFAELLDRVRQTNAAAYAHQQVPFERLVEVLNPARSLSHHPLF 6089 Query: 377 LVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE--FEYQQQL- 433 V L A G A + +R GA L+ +L+ +E EY L Sbjct: 6090 QVLLDLQ----AAGAAPELTGLRAEVEGAETGVAKFDLSFSLEESAAGLEGIVEYATDLF 6145 Query: 434 SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKX 493 V ++ + +L+ A+P+ + +D+L A ER +LA + ++ + Sbjct: 6146 ERKTVRGLVERFERLLTAVAADPDTRVGDIDLLAADERTRLLATWNDTARDIEPRSF--P 6203 Query: 494 XXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEF 553 D AEL Y+EL RRANRLARW I +G GPE ++G+ + S + Sbjct: 6204 DLFAEQVRRAPDAPAVAFDGAELDYAELDRRANRLARWLITRGAGPERLVGVALPRSADL 6263 Query: 554 IVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLS 613 +VA+LAVLK+GAAYLPID +YP ERI +++ D RP+ VI ++ A+ A L L Sbjct: 6264 VVALLAVLKSGAAYLPIDLSYPVERIRFMLDDGRPEFVI--TDVASADSLADAGVRLVLL 6321 Query: 614 DSDRLRPLRPG-----------------HLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 D D PG AYVIYTSGSTGRPKGV V+H I + Sbjct: 6322 DGDDTTEALPGLPATEVTAAERGVLAPAGAAYVIYTSGSTGRPKGVVVTHGGIVSLLAAQ 6381 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGV 716 + R LQF+++SFDA+ ++ + L GA L++ +A+L++R+ + Sbjct: 6382 RETLGVDGRSRVLQFAALSFDAAAWEMCMGLLSGACLVLAPAHELLPGEALAELVARQRI 6441 Query: 717 TVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEA 776 T + V GEA P + +++ D + N YGPTE Sbjct: 6442 THLTLPPTALGVLPDDALPAGTTLV----VAGEACPPALVAKWSR--DRTMINAYGPTET 6495 Query: 777 VVCSTHMVVTGSHGARVVP-IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYL 835 VC+T ++ VVP IG P N YVLD L PVP GELY+ G+ LARGY Sbjct: 6496 TVCAT---MSAPLAGEVVPAIGGPITNARVYVLDAGLRPVPPGTTGELYVAGAGLARGYA 6552 Query: 836 GRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVE 894 GR LTA+RF+ADPF G R+YRTGDL R + G L + GRAD QVK+RGFRIELGEVE Sbjct: 6553 GRAGLTAERFVADPFGAAGERMYRTGDLARWSADGVLHYAGRADHQVKVRGFRIELGEVE 6612 Query: 895 SVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFA 953 + + HP V + E G L AY+VP A+ + ++RA A+A+PEYMVP AF Sbjct: 6613 AALDRHPGVGQVTALVREDNPGDRRLVAYVVPEGARPEPSDLRALAASALPEYMVPSAFV 6672 Query: 954 VIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFF 1013 ++ E+P+ +GK+DRRALPAP +AT P T E +C +FA++ VG +D FF Sbjct: 6673 LLDELPLLPNGKVDRRALPAPDFVATSG-AAPRTRREEVLCGLFAEVLRVPSVGIDDGFF 6731 Query: 1014 GLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAAD 1073 LGG S+L+ +LV++ R E G+ L+ + +F T LA +AA Sbjct: 6732 ELGGDSILSLQLVSRARRE-GLVLSPQDVFAHRTVRKLA-----------------VAAG 6773 Query: 1074 DMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXX 1133 D + A G P+ H W + E FN + LR Sbjct: 6774 DGGEVEEEAGSGI---GEFPATPIMH-----WLREHTEHF-AGFNQSMVLRVPADLGADR 6824 Query: 1134 XXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLA--VRAIDQDEFDDVST----- 1186 H+ALR + G +++ P V+ A VR +D + DD + Sbjct: 6825 LTTAVQALVDTHDALRLRL--NPGWRPEVL-PRGEVRAADLVRRVDVEGLDDTALAEVVA 6881 Query: 1187 ---QLRRHVFTPESGPLLQANLLVLGP-DTHVLLLIVHHIVSDHASLEIVFDDLIVAYRA 1242 R PE+G + + GP LL++VHH+ D S ++ DL +A+ Sbjct: 6882 EHGDAARDRLAPENGAVARFVWFDAGPRAAGRLLVVVHHLAVDGVSWRVLLPDLAIAW-- 6939 Query: 1243 RLQHNAPQWDILPIQFADYAVWQRNTFESNWGQ--TELDYWRDALAGLPDEISVATDRAR 1300 H A + + P++ + QR E+ + EL+ W+ L G P AR Sbjct: 6940 ---HTAGE-GLEPVRTSLRRWAQRLAEEAVRPERVRELELWKGVL-GEPG--------AR 6986 Query: 1301 PRVLGKRGEVVQFSVPAA-RRAALTQLAER-NGATEFMLYQAALAVVLHKLGGG----TD 1354 PR + GE ++ ++P RA LT + R + + +L A VLH G +D Sbjct: 6987 PRPGTEAGE-LEITIPVEDTRALLTTVPARFHAGVDDVLLVALAVAVLHVRGEDGDRRSD 7045 Query: 1355 IALGSPVAAR---VEPATAQLVGLFANVVVLRTD 1385 + + R V+ ++ VG F N+ +R D Sbjct: 7046 VVVDVESHGREPVVDGDLSRTVGWFTNLHPVRLD 7079 Score = 373 bits (957), Expect = e-100 Identities = 252/650 (38%), Positives = 340/650 (52%), Gaps = 84/650 (12%) Query: 807 VLDEQLHPVPDQVIGELYL--GGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVR 864 VLDE P+P V+GEL++ GG +A G+ R R GD V Sbjct: 3744 VLDEAGRPLPAGVVGELHVDSGGGLVATGHRAR--------------------RRGDRV- 3782 Query: 865 RNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLV 924 E V R V++RG + L EVE ++ V V + + P+ AY Sbjct: 3783 -------EVVARKGRYVRLRGIGVSLDEVERILAGAAGV----AVTIDDDGQPV--AYTT 3829 Query: 925 PAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRY-- 982 AA +RA + +PEY VP F + +P+ V G++D ALPA +RR+ Sbjct: 3830 DPAA------VRARAESQLPEYAVPSRFVAVDVLPV-VDGEIDYAALPA----LSRRHER 3878 Query: 983 REPETATERWICSIFAQLFGRQR-VGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRT 1041 R P + E +C +F ++ G R V E+SFF LGG SL A RL+++IRA FGV L+VR+ Sbjct: 3879 RGPRSPREEILCGLFGEVLGLGRPVEPEESFFELGGQSLSAIRLLSRIRATFGVQLSVRS 3938 Query: 1042 IFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQ 1101 +F PT AG+ RL E A P P AR RP R+PLS +Q Sbjct: 3939 LFTEPTVAGVVGRLDE--------------ASAAPRTPLTARQ------RPDRVPLSFAQ 3978 Query: 1102 LAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQ 1161 WF R+EG +N+PL LR +G RHE+LRT F E +G P+Q Sbjct: 3979 QRLWFLSRLEGPSATYNVPLVLRLQGRLDAAALEAAVRDVFDRHESLRTVFPEVDGEPHQ 4038 Query: 1162 IVHPS----RTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLL 1217 V + RTV++A E D+ + RH F S L+A L +G D HVLLL Sbjct: 4039 HVVGTFPGLRTVEVA-----PGELDERLAEESRHTFDFTSECPLRATLFRVGADEHVLLL 4093 Query: 1218 IVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWG--- 1274 ++HHI +D S E DL AY AR Q PQ LP+Q+ADY +WQR F S Sbjct: 4094 LMHHIATDGGSDEPFARDLSAAYAARRQGQEPQLPPLPVQYADYTLWQREVFGSEDDPES 4153 Query: 1275 --QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGA 1332 ++ +W+ ALA LPD + + TDR RP V GE + F VPA A L +LA + Sbjct: 4154 VVSRQIAHWQQALADLPDRLELPTDRPRPAVASYEGEELGFVVPAELHAELLELARKTDT 4213 Query: 1333 TEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTL 1392 T FM+ QAALA +L ++G GTDI +G+PVA R + + LVG F N +VLRTD +GDPT Sbjct: 4214 TLFMVVQAALAGLLTRMGAGTDIPIGTPVAGRGDESLEDLVGFFVNTLVLRTDTTGDPTF 4273 Query: 1393 RSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGE 1442 R +L R+ L A +HQ++P ER+VEA+NP R LS +PLFQ M+ F + Sbjct: 4274 RELLGRVREADLSAFSHQDVPFERIVEAVNPVRTLSHHPLFQVMMVFEND 4323 Score = 322 bits (826), Expect = 2e-85 Identities = 187/453 (41%), Positives = 250/453 (55%), Gaps = 31/453 (6%) Query: 990 ERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPA 1049 E + +FA++ G VG D+FF +GGHSL A RL +IR+ GV+L VR +F+APT A Sbjct: 4627 EELLRGLFAEILGVDEVGPHDNFFAVGGHSLRATRLTGRIRSALGVELPVRAVFEAPTVA 4686 Query: 1050 GLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYR 1109 GLAARL E A D ARP + P R+PLS +Q WF +R Sbjct: 4687 GLAARLAE-------------AGD--------ARPALRRMPLPDRVPLSFAQRRLWFLHR 4725 Query: 1110 IEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV 1169 +EG +N+PL LR G RH++LRT F E +GVP+Q+V R Sbjct: 4726 MEGPSPAYNIPLVLRLSGELDVRALRGAFGDVVSRHDSLRTLFAETDGVPHQVV-VDREA 4784 Query: 1170 QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASL 1229 AV D + R+ F S ++A L H LL+++HHI +D S Sbjct: 4785 PFAVLPPSPGGLVDAA----RYCFDLASELPVRATLFGEDDQRHTLLVLLHHIAADGGST 4840 Query: 1230 EIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDA 1284 E + DL AY AR+ AP W+ L +Q+ADY WQ S + T++++W D Sbjct: 4841 EPLLRDLASAYAARVGGGAPDWEPLAVQYADYTAWQHELLGSEDDPGSLASTQVEFWCDR 4900 Query: 1285 LAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAV 1344 LAGLPD + + TDR RP + RG V A AA+T+LA G T FM+ QA LA Sbjct: 4901 LAGLPDRLELPTDRPRPTIASHRGGAVDVRFDAELHAAVTELARSRGVTVFMVLQAGLAA 4960 Query: 1345 VLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVL 1404 VL +LG GTD+ +G+PVA R + A +LVG F N +VLR D+SGDP+ +L R+T L Sbjct: 4961 VLSRLGAGTDVPIGTPVAGRSDAALEELVGFFVNNLVLRNDVSGDPSFAELLERVRETNL 5020 Query: 1405 DALAHQELPIERLVEALNPPRALSRNPLFQNML 1437 A AHQ++P ERLVE LNP R+LS +PLFQ M+ Sbjct: 5021 AAYAHQDVPFERLVEVLNPARSLSHHPLFQVMM 5053 Score = 311 bits (796), Expect = 7e-82 Identities = 185/466 (39%), Positives = 252/466 (54%), Gaps = 30/466 (6%) Query: 983 REPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTI 1042 R P T E + +F + G V +DSFF LGGHSL A RL++++R+ FGV+L++R + Sbjct: 2140 RAPRTPREEILRGLFCDVLGTTEVSIDDSFFELGGHSLSAIRLLSRLRSMFGVELSLRHL 2199 Query: 1043 FDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQL 1102 F+ PT AGLAA+ D R R RP +PLS +Q Sbjct: 2200 FEQPTVAGLAAQFG---------------------DADRTRVVLEPFTRPDPMPLSFAQW 2238 Query: 1103 AAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQI 1162 WF + +E + PL LR G RHE LRT + E +G P+Q+ Sbjct: 2239 RLWFLHELEDDSATYTEPLLLRLSGELDTDALRAAIGDVVARHETLRTVYPETDGTPHQV 2298 Query: 1163 VHPSRTVQLAVRAIDQDEFDDVSTQLR---RHVFTPESGPLLQANLLVLGPDTHVLLLIV 1219 V P + V + DE D ++ LR R+ F + L+ L LG H LLL++ Sbjct: 2299 VLPPESSVPEVEFVRTDE-DGLAEHLRDLGRYSFDLSTELPLRVCLFWLGEREHALLLLL 2357 Query: 1220 HHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWG----- 1274 HHI SD S + DL AY ARL+ AP W LP+Q+ADYA+WQR S Sbjct: 2358 HHIASDGWSDAPLSRDLSAAYAARLRGEAPGWAPLPVQYADYALWQRELLGSETDPGSLV 2417 Query: 1275 QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATE 1334 +L +W LAGLP+ + + TDR RP V RG V+F++PA L +LA + G T Sbjct: 2418 SKQLAFWSQNLAGLPERLELPTDRPRPAVASYRGSEVEFAIPADLHRGLVELARQTGTTL 2477 Query: 1335 FMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRS 1394 FM+ QAAL+ +L ++G G DI LGS +A R + A +LVG F N +VLRTD SG PT R Sbjct: 2478 FMVVQAALSALLTRMGAGHDIPLGSVIAGRSDEALEELVGFFVNTLVLRTDTSGRPTFRE 2537 Query: 1395 ILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 ++ R L A AHQ++P ERLVE LNPPR+++ +PLFQ M+ F+ Sbjct: 2538 LVGRVRRNDLAAYAHQDVPFERLVEVLNPPRSMAHHPLFQVMVLFQ 2583 Score = 156 bits (394), Expect = 3e-35 Identities = 134/466 (28%), Positives = 203/466 (43%), Gaps = 47/466 (10%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS Q+R+WFL ++ T N+ + RL G +D L AV DV RH LRT + Sbjct: 3970 DRVPLSFAQQRLWFLSRLEGPSATYNVPLVLRLQGRLDAAALEAAVRDVFDRHESLRTVF 4029 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 + +GEP+Q G R ++ +++ A+E FD T+E PLR T Sbjct: 4030 P-EVDGEPHQHVVGTFP-GLRTVEVA-------PGELDERLAEESRHTFDFTSECPLRAT 4080 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFL 208 + R ADE VLLL++HHI D S E F +LSAAY LP+ Sbjct: 4081 LFRVGADEHVLLLLMHHIATDGGSDEPFARDLSAAYAARRQGQEPQLPPLPVQYADYTLW 4140 Query: 209 SVEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP------- 258 EV + P + +W + L P R + V Sbjct: 4141 QREVFGSEDDPESVVSRQIAHWQQALADLPDRLEL-------PTDRPRPAVASYEGEELG 4193 Query: 259 --LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL 316 +PA L + + + ARK + FMV+ AA L+ R +D + PV R + L Sbjct: 4194 FVVPAELHAELLELARKTDTTLFMVVQAALAGLLTRMGAGTDIPIGTPVAGRGDESLEDL 4253 Query: 317 -GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMD 375 G+F NTL+LR T TF + VRE L+ F+HQ V +R+V NP R Sbjct: 4254 VGFFVNTLVLRTDTTGDPTFRELLGRVREADLSAFSHQDVPFERIVEAVNPVRTLSHHPL 4313 Query: 376 LLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSL-----TIALDPDDVSVEFEYQ 430 V + F + A+ G+ R L + AA L+ + +P + + E+ Sbjct: 4314 FQVMMVFE-NDAESSFAMPGLRARFLDVDMSAARFDLTFHLQERHVGDEPGGIGCDLEFA 4372 Query: 431 QQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVL 475 L V ++ ++ L++ +A+P+ L S+++L ER VL Sbjct: 4373 VDLFDHATVRRLSERFVTLLEALVADPDARLGSVELLDDAERRIVL 4418 Score = 150 bits (379), Expect = 1e-33 Identities = 139/455 (30%), Positives = 195/455 (42%), Gaps = 29/455 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q +WFL ++ T N+ + RL G +D D L A DVVA+H LRT + Sbjct: 3287 ERLPLSFVQEGLWFLSRLEGPSATYNVPLVLRLTGELDVDALRAAFADVVAQHESLRTLF 3346 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 + G P+QV + E + + EA + + F D+ ELP+R Sbjct: 3347 P-EHGGAPHQVVLPPEQARPVLE-VVDVDEAAVGEALREASRHHF----DIATELPIRAW 3400 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA-AQFLSVEVL 213 + R D LL ++HHI D S + +L+ AY + P+ +P Q+ + Sbjct: 3401 LFRLGGDRHALLPLMHHIVSDGWSESLLGNDLATAYAARLRGEAPVFEPLPVQYADYTLW 3460 Query: 214 QNSAAPSVADVG--------YWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLPAGL 263 Q SV D G +WAE LR S A L A L Sbjct: 3461 QRELLGSVDDPGSAISRQMAFWAEALRGLPEKIELPTDHPSPAAATYLGDEAPLRLDAEL 3520 Query: 264 FSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNT 322 V++ AR + + FMV+ A L+ R +D + PV R+ A L G+F NT Sbjct: 3521 HRAVDEVARATNTTQFMVIQAGVAALLTRMGAGTDIPIGTPVAGRTDEALEDLFGFFVNT 3580 Query: 323 LLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGF 382 L++R T TF + VRET LA FAHQ V +R+V NP R V L F Sbjct: 3581 LVMRTRTHGDPTFRELLERVRETDLAAFAHQDVPFERIVEAVNPVRSLSHHPLFQVMLTF 3640 Query: 383 -NMRKSAGGLALDGVVVRQL--GLGAVAAHLPLSLTIALDPDDVSV--EFEYQQQL-SSV 436 N + GL V ++ + G+ A + L A D + E EY L Sbjct: 3641 ENFDEVEVGLPGLEVELQDVVAGVAKFAMDIRLQERYAADGSHAGIVGEIEYSTDLFERA 3700 Query: 437 LVDQMLVHYLQLVDKALAEPERPLSSLDILGAGER 471 VD L+L+ A A+P+R L LD+L GER Sbjct: 3701 TVDSFGERLLRLLRSATADPDRRLGELDVLEPGER 3735 Score = 142 bits (357), Expect = 5e-31 Identities = 137/471 (29%), Positives = 194/471 (41%), Gaps = 45/471 (9%) Query: 27 AEQSSDQPGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVN 86 AE + Q G+ LS Q +W L ++ T NI + R+ G ++ L AV Sbjct: 591 AESAQPQAGVA-----ELSAAQMGLWSLHRLEGPSATYNIPLVVRIDGPLERPALRQAVQ 645 Query: 87 DVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGR 146 DV RH LRTT+ D ++ S +V+V E +E+ + Sbjct: 646 DVAVRHETLRTTFPEDDGSPRPRLASTEVDV-----------EFVEAADVEAELVRQARH 694 Query: 147 PFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN---------- 196 PFDL NE+P R+ V+ + E V+LL++HHI D S +LSAAY Sbjct: 695 PFDLLNEIPFRVCVVSSGPREHVVLLLMHHIAADGWSERPLVADLSAAYRARLDGHAPRW 754 Query: 197 -DLPINDPAAQFLSVEVL----QNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRR 251 +LP AA+ V + +P + +W + L P Sbjct: 755 VELPTGY-AAEMRRVRAALGAEDDPTSPLSRQIRFWQDELADLPGLVELP-TDHPRPASA 812 Query: 252 AQR----RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTE 307 + R RVR + A L + AR +PFMV+ AA L+ R +D + PV Sbjct: 813 SHRGDVLRVR-MDAELHRALAGLARSTGTTPFMVVHAALAALMTRLGAGADIPLGTPVAG 871 Query: 308 R-SGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANP 366 R S +GYF NTL+LR T+ TF + VRET LA FAHQ V DRVV NP Sbjct: 872 RGSSDVDDVVGYFVNTLVLRTRTQGDPTFRELLARVRETDLAAFAHQDVPFDRVVEAVNP 931 Query: 367 ERMGRDGMDLLVRLGFNMRKSAGGLALDG-VVVRQLGLGAVAAHLPLSLTIALDPDDVSV 425 R V L F A D V ++ +G L L L D Sbjct: 932 ARSLSHHPLFQVMLTFETLAGARPDFPDARAEVDEVSIGVAKFDLDLRLREHHGEDGAPA 991 Query: 426 EFEYQQQLSSVLVDQMLVHYL-----QLVDKALAEPERPLSSLDILGAGER 471 + + S+ L ++ V L L+ A A P+ L+ L++L ER Sbjct: 992 GADGIIEYSTDLFEREGVELLWERLAALLRSAAATPDARLTELELLAPEER 1042 Score = 120 bits (302), Expect = 1e-24 Identities = 107/405 (26%), Positives = 170/405 (41%), Gaps = 37/405 (9%) Query: 880 QVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHT 939 QV +RG R++ V + HPAV V ++ L AY+V A V + ++RA+ Sbjct: 1050 QVVVRGIRLDARRVRDELAVHPAVAEAFVAGGDSG----LIAYVV--AGSVRVADLRAYL 1103 Query: 940 AAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQ 999 VP Y+VP F ++ E+P G +DR LPAP +A R P T E + +FA+ Sbjct: 1104 ERRVPSYLVPQDFVLLEEMPRDAGGSVDRERLPAP--VAREAARGPRTPQEHQLAELFAE 1161 Query: 1000 LFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERF 1059 + G G ++ FF LGG S++A RLV++ R + G+ LT R +F+ + A LAA + Sbjct: 1162 VLGVSDFGVDEGFFDLGGDSIVAIRLVSRAR-KAGLVLTPRDVFEHKSVARLAAVATRQ- 1219 Query: 1060 RNDFELDLDNLAADDMPL-DPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFN 1118 A D +P+ +P A P P+ L G + Sbjct: 1220 ---------TAATDTVPVWEPNGAVP---------LTPIMRGLLER------GGDIRGYF 1255 Query: 1119 MPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQ 1178 + LR H+ LR + V V + R ID Sbjct: 1256 QSMVLRAPAAMTEADLGAAVHALVAHHDVLRMRLESGRLVISPEVGTGFVRRADARDIDM 1315 Query: 1179 DEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIV 1238 E + T+ R P +G +L+ L G + L+++VHH+ D S +++ DL Sbjct: 1316 AEAVEQETERARAALDPAAGRVLRVCWLDAGEEPGRLVVLVHHLAVDGVSWDVLVSDLRA 1375 Query: 1239 AYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRD 1283 A+ + + + + F +A R++ G EL W D Sbjct: 1376 AWESVRAGRPVRLEPVGTSFRHWAHVLRDSAAGRQG--ELPMWTD 1418 Score = 87.0 bits (214), Expect = 2e-14 Identities = 100/408 (24%), Positives = 169/408 (41%), Gaps = 20/408 (4%) Query: 70 YRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPE 129 +RL G +D L A +++ RH LR + + QV D+VE+ W DL+ + + Sbjct: 1729 FRLDGELDAPALRDAAAELLRRHDNLRAGFRYEGLPRAVQVIPDEVELPWTEADLSDVDD 1788 Query: 130 AGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFG 189 + + L + GR FDLT LR T+IR E ++ HHI +D S + Sbjct: 1789 K--DAAVAELTTADRGRRFDLTRPPLLRFTLIRLGEREHRFVVTNHHILFDGWSMQSLLD 1846 Query: 190 ELSAAY--NDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGAN 247 EL A Y D+ P +L+ ++ AA W E L G SG + Sbjct: 1847 ELFALYRGGDVERVAPYQDYLAWLAERDRAAGE----RVWREAL--DGVEPTLFGGSG-D 1899 Query: 248 PCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTE 307 ++ V LPA R++ + R + V+ +G+L+ R D + V+ Sbjct: 1900 AVVTPEQLVLDLPADFADRLQRWLRSRGLTLNTVVQGGFGLLLARNLDREDVVFGSTVSG 1959 Query: 308 RSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREA 364 R G +G F NTL +R+ R+ ++ ++ V+E H +G++ + Sbjct: 1960 RPSELPGVESMVGMFINTLPVRVRLRAGESLGELLSRVQEEQSRLLEHHYLGLNDI---Q 2016 Query: 365 NPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVS 424 N G L V + + GV V L A H PL+L++ + + Sbjct: 2017 NLLGTGEVFDALTVVENYPHEPGESWTPVPGVEVTGLE-DHDATHYPLTLSV-VPGRTLR 2074 Query: 425 VEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGER 471 + FEY+ L +++ L L+ + P++P+ +L ER Sbjct: 2075 LRFEYRPDLFDRASAERLSRQMLALLHAFVERPDQPVGETGVLAEDER 2122 Score = 75.5 bits (184), Expect = 6e-11 Identities = 81/342 (23%), Positives = 132/342 (38%), Gaps = 41/342 (11%) Query: 1144 RHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDD-------VSTQLRRHVFTPE 1196 RH+ LR F +EG+P + V+L D + DD ++T R F Sbjct: 1750 RHDNLRAGF-RYEGLPRAVQVIPDEVELPWTEADLSDVDDKDAAVAELTTADRGRRFDLT 1808 Query: 1197 SGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYR-ARLQHNAPQWDILP 1255 PLL+ L+ LG H ++ HHI+ D S++ + D+L YR ++ AP Sbjct: 1809 RPPLLRFTLIRLGEREHRFVVTNHHILFDGWSMQSLLDELFALYRGGDVERVAP------ 1862 Query: 1256 IQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV---- 1311 + DY W + + WR+AL G+ P + G G+ V Sbjct: 1863 --YQDYLAWLAERDRAAGERV----WREALDGV-----------EPTLFGGSGDAVVTPE 1905 Query: 1312 --QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVE--P 1367 +PA L + G T + Q ++L + D+ GS V+ R P Sbjct: 1906 QLVLDLPADFADRLQRWLRSRGLTLNTVVQGGFGLLLARNLDREDVVFGSTVSGRPSELP 1965 Query: 1368 ATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRAL 1427 +VG+F N + +R L +L +L ++ L H L + + L Sbjct: 1966 GVESMVGMFINTLPVRVRLRAGESLGELLSRVQEEQSRLLEHHYLGLNDIQNLLGTGEVF 2025 Query: 1428 SRNPLFQNMLNFRGEDWALVPR-DLTGRGETTVVPLPVNFEV 1468 + +N + GE W VP ++TG + P+ V Sbjct: 2026 DALTVVENYPHEPGESWTPVPGVEVTGLEDHDATHYPLTLSV 2067 Score = 55.1 bits (131), Expect = 9e-05 Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E +L + E+L ++ DE +F LGGDSI+AI+ ++A GL P VFEH ++A Sbjct: 1152 EHQLAELFAEVLGVSDFGVDEGFFDLGGDSIVAIRLVSRARKAGLVLTPRDVFEHKSVAR 1211 Query: 1620 LAAAV--DAANGEPVVEADPPPAQEYTPM 1646 LAA A + V +P A TP+ Sbjct: 1212 LAAVATRQTAATDTVPVWEPNGAVPLTPI 1240 Score = 53.9 bits (128), Expect = 2e-04 Identities = 34/91 (37%), Positives = 50/91 (54%), Gaps = 2/91 (2%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQA-GALGLPFPPAMVFEHMT 1616 E ER L AM E+L + G+ D+ +F LGG S++A + ++ G LG+ P +F + T Sbjct: 5661 ERERVLCAMFGEVLGVDGVGIDDGFFELGGHSLLATRLVSRVRGELGVELPVRELFVNPT 5720 Query: 1617 IAELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 +A LA +DAA G A P P P+S Sbjct: 5721 VAGLAGTLDAAGGARRGPA-PGPRPARVPLS 5750 Score = 48.9 bits (115), Expect = 0.006 Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 2/91 (2%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMT 1616 + E+ L + ++LE+ G+ D+++F LGG S++ + S A G P +FE T Sbjct: 3203 QREKILCGLFGDVLEVPGVGIDDSFFDLGGHSLLVTRLVSRIRSAFGAELPLRALFETPT 3262 Query: 1617 IAELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 +A LA +D A+G V P P E P+S Sbjct: 3263 VAGLAERLDGADGARVA-LRPMPRPERLPLS 3292 Score = 48.1 bits (113), Expect = 0.010 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E L + E+L + + D+ +F LGGDSI++++ ++A GL P VF H T+ + Sbjct: 6708 EEVLCGLFAEVLRVPSVGIDDGFFELGGDSILSLQLVSRARREGLVLSPQDVFAHRTVRK 6767 Query: 1620 LAAAVDAANGEPVVE 1634 LA A A +G V E Sbjct: 6768 LAVA--AGDGGEVEE 6780 Score = 45.1 bits (105), Expect = 0.089 Identities = 36/103 (34%), Positives = 48/103 (46%), Gaps = 19/103 (18%) Query: 781 THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTL 840 T + TG GA P V YVLDE L PVP V GE+++ +L+ G Sbjct: 4531 TGVATTGEPGAER-----PAPGVAVYVLDEHLRPVPPGVFGEVHVSTPELSEG------- 4578 Query: 841 TAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEF-VGRADEQV 881 + +PF PG ++ TG+ R G LEF V + EQV Sbjct: 4579 -----VENPFGTPGRWMFPTGERARWRADGLLEFRVRESAEQV 4616 Score = 44.3 bits (103), Expect = 0.15 Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 2/82 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMTIA 1618 E L + E+L + + +N+FA+GG S+ A + + + ALG+ P VFE T+A Sbjct: 4627 EELLRGLFAEILGVDEVGPHDNFFAVGGHSLRATRLTGRIRSALGVELPVRAVFEAPTVA 4686 Query: 1619 ELAAAV-DAANGEPVVEADPPP 1639 LAA + +A + P + P P Sbjct: 4687 GLAARLAEAGDARPALRRMPLP 4708 Score = 40.0 bits (92), Expect = 2.9 Identities = 96/379 (25%), Positives = 149/379 (39%), Gaps = 48/379 (12%) Query: 71 RLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGW-RREDLTRLPE 129 R + E L AV+ +VA H +LR V S +V G+ RR D + Sbjct: 1261 RAPAAMTEADLGAAVHALVAHHDVLRMRLESGR-----LVISPEVGTGFVRRADARDIDM 1315 Query: 130 A-GHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFF 188 A E++ E A D LR+ + + L+++VHH+ D SW+V Sbjct: 1316 AEAVEQETERARA-----ALDPAAGRVLRVCWLDAGEEPGRLVVLVHHLAVDGVSWDVLV 1370 Query: 189 GELSAAYNDLPINDP------AAQFLS-VEVLQNSAAPSVADVGYWAETLRXXXXXXXXX 241 +L AA+ + P F VL++SAA ++ W + Sbjct: 1371 SDLRAAWESVRAGRPVRLEPVGTSFRHWAHVLRDSAAGRQGELPMWTDITSHESTPFGGL 1430 Query: 242 GVSGANPCRRAQRRV-RPLPAGLFSR-VEDFARKCSASPFMVLLAAYGV----LVRRY-T 294 + R + R + R LPA L + + D A A VLLA + RR+ T Sbjct: 1431 ALDFTRDVRGSARTLTRELPAELTGKLLTDVAAAVRARANEVLLAGLATGLADVQRRWDT 1490 Query: 295 GASDFLVSVPVTERSGAA-----AGALGYFGNTLLLRITT--RSQD------TFTSFVNE 341 G S +V + R A + +G+F + + + + R D T + Sbjct: 1491 GESAVVVELEGHGREEIAERLDLSRTVGWFTSAYPVPLDSGVRGVDELADGRTRARVLKR 1550 Query: 342 VRETCLAGFAHQSVGIDRVVREANPERMG-RDGMDLLVRLGFNMRKSAGGLALDGVVVRQ 400 V+E L G +G ++RE+ P + G + L R G ++A A DG Sbjct: 1551 VKEQ-LRGVPDNGIGYG-ILRESLPAHPAPQIGFNYLGRFGGG--EAAADWAADG---SA 1603 Query: 401 LGLGAVAAHLPLSLTIALD 419 LG GA A LPLS + +D Sbjct: 1604 LGGGADAG-LPLSYPLEID 1621 >tr|Q5YPK6|Q5YPK6_NOCFA Tax_Id=37329 SubName: Full=Putative non-ribosomal peptide synthetase;[Nocardia farcinica] Length = 14474 Score = 776 bits (2003), Expect = 0.0 Identities = 553/1528 (36%), Positives = 755/1528 (49%), Gaps = 114/1528 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 E+ LS Q+RMWFL D +V NI VA RL+G +D L AV DV+ RH LRT + Sbjct: 2111 EQVPLSLSQQRMWFLNRFDGSNVAYNIPVAMRLSGDLDIAALQVAVIDVIDRHESLRTVF 2170 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +TE P QV D ++ DLT P E + D FD+T+E+PL Sbjct: 2171 P-ETEHGPVQVVLDAAQIV---PDLT--PYRVTEETLIDHLVDLASVAFDVTSEVPLHAR 2224 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFL 208 + E VL +VVHHI D S ++ AY +LP+ Sbjct: 2225 LFEISESEYVLGMVVHHISADGWSMVPLARDVMLAYAARTSWEAPAWTELPVQYADYALW 2284 Query: 209 SVEVLQNSAAPSV---ADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR--PLPAGL 263 EVL + P + + YW L V A+ R A R P + Sbjct: 2285 QREVLGSEDDPQSLISSQIRYWTRQLADLPDEL----VLPADHPRPAAASYRGGTYPFVI 2340 Query: 264 FSRVE----DFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GY 318 + + R+ +AS FMV+ +A VL+ R +G SD + PV R AA L G Sbjct: 2341 SEETQRALVELGRRYNASLFMVMHSALAVLLARASGTSDIAIGTPVAGRGEAALDDLIGM 2400 Query: 319 FGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLV 378 F NTL+LR +F +N+ RET L FAH V +R+V NP R V Sbjct: 2401 FVNTLVLRTEVSGSASFADLLNQARETDLQAFAHADVPFERLVEVLNPARSQARHPLFQV 2460 Query: 379 RLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDDVSVEFEYQQQ 432 L F K A L L G+ V + A A L LT+ +P +S EF Y Sbjct: 2461 MLAFQNTKQAT-LQLPGLSVSGIDYDAGLAKFDLQLTLQEAQDERGEPAGMSAEFSYALD 2519 Query: 433 LSSVLVDQMLVHYLQLVDKALA----EPERPLSSLDILGAGERDSVLAQSHGELVEMPAT 488 L + + + + +D+ LA +P+ P+ +D+L E VL + EMPA Sbjct: 2520 LFE---EPTVAAFARRLDRVLAAVVADPDVPIGDIDLLAPEEHARVLVDWNDTAHEMPAA 2576 Query: 489 TMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMA 548 T+V V + +LTY EL R+ R+AR + G GPE ++ L + Sbjct: 2577 TLVSLFYAQVEATPDAVAL--VYADEQLTYRELRERSARVARDLMAAGVGPESLVALGIR 2634 Query: 549 NSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR-------------P 595 S E +VAM AVL+AG AY+P+DP P +RI++++ ARP V+ P Sbjct: 2635 RSTELVVAMYAVLQAGGAYVPLDPDQPADRINHILDTARPALVLTTRRDNFADVVADAVP 2694 Query: 596 ELDVAERAA-ADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQ 654 L V + A A S P++D++R PLRPG+ AYVI+TSGSTGRPKGVAV H AI + Sbjct: 2695 TLFVEDLPADAATSGAPITDAERPAPLRPGNTAYVIFTSGSTGRPKGVAVGHAAIVNRLL 2754 Query: 655 GFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRR 714 A++ + AED LQ + +FD S+ + F L GA+L+V KPD D Y+A +I+ + Sbjct: 2755 WMQAQYPIGAEDAVLQKTPATFDVSVWEFFWPLQTGARLVVAKPDGHRDPVYLAQIIAEQ 2814 Query: 715 GVTVXXXXXXXXXXXXXXXXXXQWR------QLRHVPVGGEALPGEVADRFAGYFDAELR 768 G+T +LR V GEALP A R A L Sbjct: 2815 GITTAHFVPSMLAVFVSTLGNDNGDSPLPAPRLRQVFASGEALPAATARRLCELTGARLH 2874 Query: 769 NHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGS 828 N YGPTEA V T+ VT + V PIG P N +VLD +LHPV V GELYL G Sbjct: 2875 NLYGPTEAAVDVTYHEVTAADVVSV-PIGRPVWNTRVFVLDARLHPVAPGVAGELYLAGD 2933 Query: 829 QLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFR 887 QLA GY+GRP LTA RF+A+PF G RLYRTGDLV GELE++GR D QVK+RG R Sbjct: 2934 QLALGYVGRPDLTADRFVANPFGGVGSRLYRTGDLVAWTKSGELEYLGRTDFQVKLRGLR 2993 Query: 888 IELGEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPE 945 IELGE+E+ ++ P V +VV + AG L Y+V + A VD+ +RA +A +P Sbjct: 2994 IELGEIEAALSAQPGVAQSVVVVRSDPHAGDQLVGYVVAGSDASVDVAAVRAGLSAVLPG 3053 Query: 946 YMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQR 1005 YMVP A V+ P SGKLDR+ALPAP + +R P T E + IFA L G +R Sbjct: 3054 YMVPAAIVVLDAFPTNASGKLDRKALPAPV-FEAKTFRAPSTPIEEIVADIFADLLGVER 3112 Query: 1006 VGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFEL 1065 +G +D FF LGG+SL+A ++ A++ ++ VRT+F+APT LAAR+ Sbjct: 3113 LGVDDDFFALGGNSLVATQVAARLSKALDTEVGVRTLFEAPTVGALAARVESHAGTG--- 3169 Query: 1066 DLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIE------GAREEFNM 1119 R RP+ PLS +Q WF R + GA +N+ Sbjct: 3170 ----------------VRQALTAVGRPEHPPLSLAQQRMWFLNRFDTGPDAGGAASTYNI 3213 Query: 1120 PLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQD 1179 P A+R G RHE LRT + HEGV YQ V P+ V ++ Sbjct: 3214 PAAVRLRGLLDVAALRGAVADVVARHETLRTVYPSHEGVAYQRVLPAARAIPEVDVVETA 3273 Query: 1180 EFDDVSTQLRRHV---FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDL 1236 E D+ +L V F + P ++ + LG +VL L+VHHI +D S+ + DL Sbjct: 3274 E-QDLLGRLYDFVNAGFDVTAEPPVRLRIYELGERDYVLALVVHHIAADGFSMRPLVRDL 3332 Query: 1237 IVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT-----ELDYWRDALAGLPDE 1291 + AY AR + P W L +Q+ D+A+WQR T T +LDYWR ALA LPDE Sbjct: 3333 MTAYVARTGNTEPGWSPLDVQYIDFALWQRETLGDEDDPTSLIAQQLDYWRTALADLPDE 3392 Query: 1292 ISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGG 1351 + + + RP V R +F VP L ++A NG T FM+ A A +L +L G Sbjct: 3393 LRLV-HKPRPNVASYRAGTHRFRVPGELIDRLNRVAHANGTTLFMVVHGAFATLLSRLSG 3451 Query: 1352 GTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQE 1411 DIA+G PVA R E A LVG+F N +VLRT + +L R+ L A AH + Sbjct: 3452 ADDIAIGIPVAGRGEQALDDLVGMFVNTLVLRTQVDTATPFTDLLAQVRERDLAAFAHAD 3511 Query: 1412 LPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALL 1471 +P ERLVE LNP R+ +R+PLFQ ML+F ++ +L G TV L ++ A Sbjct: 3512 VPFERLVEVLNPARSQARHPLFQVMLSF--QNLGRTSLELPG---LTVEELGIDPPTAKF 3566 Query: 1472 FLAIGMSVTP--SGELDVQVIANADLYE 1497 L + +S P E+D +++ DL++ Sbjct: 3567 DLQLTLSEIPGAEAEMDAELVYATDLFD 3594 Score = 760 bits (1963), Expect = 0.0 Identities = 508/1473 (34%), Positives = 729/1473 (49%), Gaps = 109/1473 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+RMWFL D N+ +A RL G +D L TA+ D++ RH +LRT Y Sbjct: 11165 ERIPLSLAQQRMWFLNRFDTQSAAYNVPMAVRLTGELDVTALRTAIADLIGRHEVLRTVY 11224 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G+P Q+ + + A +IE+ + G+PFD+T+++P+R+T Sbjct: 11225 PA-VDGDPVQLILSPAQA-----QVPLATRAIAAAEIENAVVELVGQPFDVTDQVPVRVT 11278 Query: 160 VIRT----RADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPA 204 + E V+ +VVHHI D S+ +L AY + LP+ Sbjct: 11279 LFEITDAGEVPEYVIAMVVHHIAGDGSSFAPLVRDLMTAYVARSMGEAPNWSPLPVQYAD 11338 Query: 205 AQFLSVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXGV----------SGANPCRR 251 E+L + P+ + YW L GA P R Sbjct: 11339 YSIWQRELLGSEDDPTSLMAGQLAYWKTALADLPEQLDLPADRPRPATQSFRGGAVPVRI 11398 Query: 252 AQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA 311 R L A + SA+ FMV+ A VL+ R +GA D + P+ R A Sbjct: 11399 DAETHRKLIA--------VGQAESATLFMVVHTALAVLLSRLSGADDIAIGTPIAGRGEA 11450 Query: 312 AAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMG 370 A L G F NTL+ R + F + RE + FAH V +R+V NP R Sbjct: 11451 ALNDLIGTFINTLVFRSRVAPGEPFDVLLARQREIDIQAFAHADVPFERLVEVLNPARST 11510 Query: 371 RDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD------VS 424 V L F ++ L L G+ V + + L L + D+ V+ Sbjct: 11511 ARHPLFQVGLSFQ-NQTQTALELPGLTVSGVDFDTRMSQFDLHLILTDQYDEQGAPIGVA 11569 Query: 425 VEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELV 483 Y L + +L+L+D +A P+ + L++L A ER ++A + Sbjct: 11570 GVLTYAADLFDRATAEGFAQRFLRLLDAVIAAPDTAVGDLELLDAAERRELVAGRND--T 11627 Query: 484 EMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDII 543 P + + AELTY E R NRLAR I +G G E ++ Sbjct: 11628 AHPLAPALLLDGYRRAVAAHADAVALSYEGAELTYREFDERVNRLARLLIARGVGAESLV 11687 Query: 544 GLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERA 603 GL + S++ +V M A++ AG AY+P+DP +P ERI +++ A+P V+ V A Sbjct: 11688 GLAVRRSLDLVVGMYAIVTAGGAYVPLDPDHPAERIAHILDTAQPACVLSTTADAVPVPA 11747 Query: 604 AAD-----------NSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEH 652 D S P++ ++ +RP+R + AYVI+TSGSTGRPKGVAVSH AI Sbjct: 11748 GTDLVLLDTVDLAGYSAAPVAAAELVRPVRGDNPAYVIFTSGSTGRPKGVAVSHGAIDNQ 11807 Query: 653 VQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLIS 712 ++ ++E+ M D +LQ ++ +FD SL F+ L GA+L+V D D +YVAD+I+ Sbjct: 11808 IEWMLSEYPMGPGDVYLQKTATTFDVSLWGYFMPLRAGAKLVVATHDGHRDPAYVADMIA 11867 Query: 713 RRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYG 772 R GVTV LR V V GEALP E + + DA L N YG Sbjct: 11868 RHGVTVTDFVPSMLSVFAANLATGSVPTLRDVFVIGEALPPETVNAWYQVSDAVLHNLYG 11927 Query: 773 PTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLAR 832 PTEA V T+ G R VPIG+P NV YVLD +L PVPD V GELYL G+QLAR Sbjct: 11928 PTEAAVSVTYWPARG-RDERTVPIGLPQWNVGVYVLDSRLRPVPDGVAGELYLAGAQLAR 11986 Query: 833 GYLGRPTLTAQRFIADPFNPGMRLYRTGDLVR-RNHCGEL----EFVGRADEQVKIRGFR 887 GY+ RP L+A RF+A+PF G R+YRTGDLV R G+L E++GR D QVK RG R Sbjct: 11987 GYVARPDLSADRFVANPFVAGQRMYRTGDLVVWRAASGDLPHRLEYIGRTDFQVKFRGQR 12046 Query: 888 IELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQV-DLEEIRAHTAAAVPEY 946 IELGE+E+ + PA+ + + + G L AY+VP QV + + A + +P Y Sbjct: 12047 IELGEIETALLAQPAISQAVALVVPSSLGDQLVAYVVPRPGQVAEQNALLAAVSQTLPAY 12106 Query: 947 MVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRV 1006 MVP A V+ P+ SGKLDR+ALP P +++ +R P T E + +FA + G +RV Sbjct: 12107 MVPAAIVVLDAFPLNASGKLDRKALPEPV-FSSKEFRAPATPIEEIVAGVFADVLGLERV 12165 Query: 1007 GAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELD 1066 GA+D FF LGG+SL+A ++ A++ L VR +F+A T LAAR + Sbjct: 12166 GADDDFFALGGNSLVATQVTARLGKALDTQLAVRDLFEASTVEALAARAERKTGTG---- 12221 Query: 1067 LDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIE-GAREEFNMPLALRF 1125 RARP V RP+R+PLS +Q WF + + A N+P A+R Sbjct: 12222 --------------RARPALVAGPRPERIPLSPAQARYWFLNQFDPSASAVDNVPFAVRL 12267 Query: 1126 EGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVS 1185 G RHE LRT + +G P Q+V P+ ++R ++ E + ++ Sbjct: 12268 TGALDVSALERAVADIFARHEVLRTVYPTVDGEPVQVVLPAGQATPSLRPVEITESELIA 12327 Query: 1186 TQLRRHVFTPE---SGPLLQANLLVL----------GPDTHVLLLIVHHIVSDHASLEIV 1232 T + + T + PL A + P+ HV+ + HH+ +D AS+ + Sbjct: 12328 TVIDFVLTTFDVTAEVPLKVALFRIADSAAPAQHPTAPEQHVIAFVAHHVSADGASMGPL 12387 Query: 1233 FDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAG 1287 DL+ AY AR APQW LP+Q+ADYA+WQR + + ++ YW+ ALAG Sbjct: 12388 ARDLMTAYMARAAGEAPQWAPLPVQYADYALWQREVLGTEDDPESVAAQQVAYWKSALAG 12447 Query: 1288 LPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLH 1347 LPD++ + DR RP V RG V+F + A A L ++A N A+ FM+ AALAV+L Sbjct: 12448 LPDQLELPADRPRPPVQSFRGSAVRFEIDPALHARLHEVARANNASLFMVVHAALAVLLA 12507 Query: 1348 KLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDAL 1407 +L G DIA+G+P+A R E ++G+F N +V RT + +L R+ L A Sbjct: 12508 RLSGTDDIAVGTPIAGRGERELDDMIGMFVNTLVFRTQVRPGDAFTDLLAEVRERDLQAF 12567 Query: 1408 AHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 AH ++P ERLVE LNP R+ +RNPLFQ L+F+ Sbjct: 12568 AHADVPFERLVEVLNPVRSTARNPLFQMGLSFQ 12600 Score = 756 bits (1953), Expect = 0.0 Identities = 512/1464 (34%), Positives = 721/1464 (49%), Gaps = 92/1464 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS Q+RMWF+ DP T N+ RL G VD L A+NDV+AR LRT + Sbjct: 1031 DRVPLSLAQQRMWFINQFDPTAPTYNLPFVVRLRGNVDIAALKAALNDVMARQESLRTIF 1090 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G QV DD +L ++ E ++ + A+ FD+ ELP+R+ Sbjct: 1091 PESGDGGYQQVIPDD------EINLAIAVQSIDESELPATLAEFAATGFDVARELPIRVR 1144 Query: 160 VIRTRADEL------VLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPIND 202 + R + VVHHI D S+ +++AAY LP+ Sbjct: 1145 IFRVTGGSTNGTPDHAVAFVVHHIAADGFSFGPLSRDVAAAYLARAAGEAPQWAPLPVQY 1204 Query: 203 PAAQFLSVEVLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANPCR--RAQRRVR 257 E+L + + P + + YW L P + R Sbjct: 1205 QDYSIWQRELLGSESDPESMAARQIAYWRRQLAGLPDQLELPTDRPRPPVQSFRGATTHF 1264 Query: 258 PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL- 316 + A L + + AR S FMV+ AA VL+ R +G +D + P+ R A L Sbjct: 1265 EIDAELHAELAQLARAQGVSLFMVVHAALAVLMGRLSGTTDVAIGTPIAGRGEQALDDLI 1324 Query: 317 GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDL 376 G F NTL+LR FT F+ RET L FAH V +R+V NP R Sbjct: 1325 GMFVNTLVLRSDVDGGQPFTEFLARTRETDLQAFAHADVPFERLVEVLNPTRSQARHPLF 1384 Query: 377 LVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVSVEFEYQ 430 V L F + G L L G+ V + A L T+ P +S Y Sbjct: 1385 QVMLSFQ-EMAHGTLELPGLTVSAAEVEVPIAKFDLLWTLTEQRASTGAPAGISAVLSYA 1443 Query: 431 QQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATT 489 L V++ +L+++ E + ++IL A ER++VL + E+P T Sbjct: 1444 TDLFDRATVEEFNHRFLRVLRAVTREASTAVRDIEILDAAERETVLTGWNRTAHEVPPVT 1503 Query: 490 MV----------KXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGP 539 V + A LTY E R NRLAR I +G GP Sbjct: 1504 TVIELFDATARRRAHATALLFDPGERSEGEYGPAAALTYGEFAARVNRLARKLIEEGVGP 1563 Query: 540 EDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDV 599 + ++ + + S++ +VA+ A + AG Y+PIDP +P ER +Y++ +RP ++ DV Sbjct: 1564 DTLVAVGIRRSLDMLVAVYAAVAAGGGYVPIDPDHPAERTEYVLASSRPVVLLTTSGDDV 1623 Query: 600 AERAA----ADNSDL------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAI 649 D DL P+ ++R +RP + AYV+YTSGSTGRPKGVAV+H A+ Sbjct: 1624 TGGDCPVLHVDTLDLDGYPDGPIDPAERRGVVRPENTAYVLYTSGSTGRPKGVAVTHAAM 1683 Query: 650 AEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVAD 709 + +AE + D L + +FDAS+ ++F TL +GAQ+IV PD D Y ++ Sbjct: 1684 VNQMAWKIAESGLDETDVVLHKTPFTFDASVWELFATLIVGAQVIVAAPDGHRDPLYQSE 1743 Query: 710 LISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRN 769 +I R VT+ + LR + VGGEAL F A + N Sbjct: 1744 VIWRHQVTMTSFVPSLLSVFASTAPAAECSSLRAIFVGGEALTSSTVALFRRLSPATVVN 1803 Query: 770 HYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQ 829 YGPTE V +T V +G VPIG P N AYVLDE L PVP V GELYLGG+Q Sbjct: 1804 LYGPTEFTVNATSWRVI-DNGGGAVPIGRPVWNARAYVLDEALRPVPAGVAGELYLGGAQ 1862 Query: 830 LARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNH-----CGELEFVGRADEQVKI 883 +ARGY GRP LTA+RF+ADPF PG RLYRTGDLVR N G LE++GR D QVK Sbjct: 1863 IARGYHGRPDLTAERFVADPFGEPGERLYRTGDLVRWNRNAHSEFGVLEYIGRTDFQVKF 1922 Query: 884 RGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQVDLEEIRAHTAAAV 943 RG RIELGE+E+ + PA+ +V+ +T AG L AY+V A ++D EE++ + Sbjct: 1923 RGQRIELGEIEAALLEQPAINQAVVLVIDTVAGDQLVAYVV-GAGEIDTEEVKTALRRRL 1981 Query: 944 PEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGR 1003 P YMVP +PE P+ SGKLDR+ALPAP R +R P T E + IF ++ G Sbjct: 1982 PAYMVPSVVVALPEFPLNASGKLDRKALPAPV-FEVREFRAPTTPIEEIVAQIFGEVLGL 2040 Query: 1004 QRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDF 1063 RVG +D FF LGG+SL+A ++ +++ + VR +F+A T A LAAR+ Sbjct: 2041 PRVGVDDDFFDLGGNSLIATQVASRLGIALDTRVPVRMLFEASTVAALAARV-------- 2092 Query: 1064 ELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLAL 1123 ++ A D AR V RP+++PLS SQ WF R +G+ +N+P+A+ Sbjct: 2093 ----ESQAGDG-------ARKALVAKDRPEQVPLSLSQQRMWFLNRFDGSNVAYNIPVAM 2141 Query: 1124 RFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV--QLAVRAIDQDEF 1181 R G RHE+LRT F E E P Q+V + + L + ++ Sbjct: 2142 RLSGDLDIAALQVAVIDVIDRHESLRTVFPETEHGPVQVVLDAAQIVPDLTPYRVTEETL 2201 Query: 1182 DDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYR 1241 D L F S L A L + +VL ++VHHI +D S+ + D+++AY Sbjct: 2202 IDHLVDLASVAFDVTSEVPLHARLFEISESEYVLGMVVHHISADGWSMVPLARDVMLAYA 2261 Query: 1242 ARLQHNAPQWDILPIQFADYAVWQRNTFESNWG-----QTELDYWRDALAGLPDEISVAT 1296 AR AP W LP+Q+ADYA+WQR S +++ YW LA LPDE+ + Sbjct: 2262 ARTSWEAPAWTELPVQYADYALWQREVLGSEDDPQSLISSQIRYWTRQLADLPDELVLPA 2321 Query: 1297 DRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIA 1356 D RP RG F + + AL +L R A+ FM+ +ALAV+L + G +DIA Sbjct: 2322 DHPRPAAASYRGGTYPFVISEETQRALVELGRRYNASLFMVMHSALAVLLARASGTSDIA 2381 Query: 1357 LGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIER 1416 +G+PVA R E A L+G+F N +VLRT++SG + +L +R+T L A AH ++P ER Sbjct: 2382 IGTPVAGRGEAALDDLIGMFVNTLVLRTEVSGSASFADLLNQARETDLQAFAHADVPFER 2441 Query: 1417 LVEALNPPRALSRNPLFQNMLNFR 1440 LVE LNP R+ +R+PLFQ ML F+ Sbjct: 2442 LVEVLNPARSQARHPLFQVMLAFQ 2465 Score = 754 bits (1948), Expect = 0.0 Identities = 503/1452 (34%), Positives = 711/1452 (48%), Gaps = 87/1452 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+RMWFL D NI +A R+ G +D + L AV DV+ RH +LRT Y Sbjct: 9034 ERIPLSLAQQRMWFLNRFDSATAVNNIPLAVRMVGELDIEALRQAVADVIDRHEVLRTVY 9093 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G+ QV + G DL P E ++ ++ FD+T +P+R Sbjct: 9094 PETADGQGVQVI---LPAGSHTLDLH--PIVVEEAELTERVSELVLTGFDVTQSVPVRAA 9148 Query: 160 VIR-------TRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA-AQ 206 + R ++ VL+ VVHH+ D S ++ AY + P P Q Sbjct: 9149 LFRVAGSMDGSQPPTHVLVFVVHHVSGDGWSVGPLARDVMVAYAARSRGEAPGWAPLPVQ 9208 Query: 207 FLSVEVLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP 258 + + Q S D V YW+ L P R + V Sbjct: 9209 YADYAIWQRDVLGSEDDPDSLISEQVAYWSRQLAGLPDQLDL-------PADRKRPAVAS 9261 Query: 259 LPAGLF---------SRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERS 309 G++ + +++ R AS FMV+ AA+ L+ R +G+ D V V R Sbjct: 9262 NRGGVYEFGLDDALVAELDELGRAHGASLFMVVHAAFAALLARLSGSDDIAVGTVVAGRG 9321 Query: 310 GAAAG-ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER 368 AA A+G F NTL+LR ++FT + +RET LA F H + +R+V NP R Sbjct: 9322 EAALDDAIGMFVNTLVLRSAVDPAESFTDLLTRIRETDLAAFGHADLPFERLVELLNPAR 9381 Query: 369 MGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFE 428 V L F L G+ V L L V A L L D E Sbjct: 9382 SQARHPLFQVMLSFQ-NTGETTFELPGLEVSGLPLDVVTAKFDLHLNFHTGADGTKAEIA 9440 Query: 429 YQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPA 487 Y + + V ++++ A+ + +++L E + + + P Sbjct: 9441 YAADMFDAPTVASFAERLVRMLSAVAADARVAVGDVELLDPAEHARL---ARWNATDRPV 9497 Query: 488 TTMVKXXXXXXXXXXXXXXXXXVSDEA-ELTYSELHRRANRLARWFIGQGFGPEDIIGLR 546 T ++ E L+Y E R + LAR + G GPE ++ L Sbjct: 9498 DTEATLVSMFEAQAARTPETVALTFEGTSLSYGEFAARVHTLARHLVELGVGPESMVALG 9557 Query: 547 MANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR----------PE 596 M S+E ++ M AV AG AY+P+DP +P ERI Y++ A P V+ P Sbjct: 9558 MRRSLELVIGMYAVSAAGGAYVPLDPDHPAERIAYVLDVAAPVCVLTTSGDEFDAGTVPT 9617 Query: 597 LDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 +++ +D PL+D+DR PLRP + AYVI+TSGSTGRPKGVAV+H AI + Sbjct: 9618 VEIDRLDLDGYADTPLTDADRRAPLRPSNTAYVIFTSGSTGRPKGVAVTHAAIVNRLVWM 9677 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGV 716 +E+ + D LQ + +FD S+ + F L +GA+L+V KPD D +Y+ +LI+ + + Sbjct: 9678 QSEYGLDRTDVVLQKTPATFDVSVWEFFWPLQVGARLVVAKPDGHRDPAYLVELITGQRI 9737 Query: 717 TVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEA 776 T + LR+V GEALP A R A L N YGPTEA Sbjct: 9738 TTAHFVPSMMSVFVAEDRAAECTSLRNVFASGEALPAVTAQRLRELTGARLHNLYGPTEA 9797 Query: 777 VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLG 836 V T+ V + V PIG P N +VLD +LHPVP V GELYL G QLARGY+ Sbjct: 9798 AVDVTYHEVVDADTVSV-PIGAPVFNTRVHVLDSRLHPVPVGVAGELYLAGVQLARGYVA 9856 Query: 837 RPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESV 896 RP LTA RF+ADPF G R+YRTGDLV GELE++GR D QVK+RG RIELGE+ES Sbjct: 9857 RPDLTADRFVADPFGDGQRMYRTGDLVAWTADGELEYLGRTDFQVKLRGLRIELGEIESA 9916 Query: 897 ITTHPAVRHCLVVAEETE-AGPMLAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAV 954 +T ++ +VV E G L AY++ AA + +D+E +R A A+P YMVP AF V Sbjct: 9917 LTALDSIAQAVVVVRSDERLGDQLVAYVIAAAGRSIDIEAVRGELAGALPGYMVPSAFVV 9976 Query: 955 IPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFG 1014 + P+ SGKLDR+ALPAP + +R P T E + F + G RVG +D FF Sbjct: 9977 LDAFPLNASGKLDRKALPAPV-FEAKVFRAPSTPVEEIVAGTFGDVLGVARVGLDDDFFA 10035 Query: 1015 LGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADD 1074 LGG+SLLA +++A++ L VR +FDA T A LAAR +++A Sbjct: 10036 LGGNSLLATQVIARLGKALDTQLAVRDLFDASTVAALAAR------------AESIAGSG 10083 Query: 1075 MPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEF-NMPLALRFEGPXXXXX 1133 R RP RP+R+PLS +Q WF + + A N+PLA+R G Sbjct: 10084 ------RTRPELTGGTRPERIPLSPAQQRYWFLNQFDTATSAVDNIPLAVRLSGALDVAA 10137 Query: 1134 XXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVF 1193 RHE LRT + P+Q++ P +L ID+ E F Sbjct: 10138 LEQAIGDVFARHEVLRTTYPSSPEGPHQVILPVVRPRLEPVDIDESELVQRVIAFSMTTF 10197 Query: 1194 TPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDI 1253 + L L + PD HV+ +VHH+ +D +S+ + DL+ AY AR+ APQW Sbjct: 10198 DVTTEVPLAVTLFRIRPDEHVVAFVVHHVAADGSSMGPLARDLMAAYVARVAGEAPQWTP 10257 Query: 1254 LPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRG 1308 LP+Q+ADYA+WQR S + ++ YW+ ALAGLPD++ + +DR RP G Sbjct: 10258 LPVQYADYALWQREVLGSEDDPDSVAARQVAYWKSALAGLPDQLDLPSDRPRPPAQSFHG 10317 Query: 1309 EVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPA 1368 + V+F + A L +LA N A+ FM+ ALAV+L +L G DIA+G+P+A R E Sbjct: 10318 KAVRFDITPELHARLHELARANNASLFMVVHTALAVLLARLSGTDDIAVGTPIAGRGERE 10377 Query: 1369 TAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALS 1428 L+G+F N +V RT + +L R+ L+A A+ ++P ERLVE LNP R+ + Sbjct: 10378 LDDLIGMFVNTLVFRTQVEPGDRFADLLAEVRERDLEAFANADVPFERLVEVLNPVRSTA 10437 Query: 1429 RNPLFQNMLNFR 1440 RNPLFQ L+F+ Sbjct: 10438 RNPLFQVGLSFQ 10449 Score = 734 bits (1895), Expect = 0.0 Identities = 523/1464 (35%), Positives = 729/1464 (49%), Gaps = 95/1464 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTL-NICVAYRLAGLVDEDRLHTAVNDVVARHAILRTT 98 ER LS Q+R WFL D + NI +A RL+G +D L A+ DV ARH +LRTT Sbjct: 10096 ERIPLSPAQQRYWFLNQFDTATSAVDNIPLAVRLSGALDVAALEQAIGDVFARHEVLRTT 10155 Query: 99 YGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRI 158 Y EG P+QV V D+ E ++ FD+T E+PL + Sbjct: 10156 YPSSPEG-PHQVILPVVRPRLEPVDID-------ESELVQRVIAFSMTTFDVTTEVPLAV 10207 Query: 159 TVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQF 207 T+ R R DE V+ VVHH+ D S +L AAY LP+ Sbjct: 10208 TLFRIRPDEHVVAFVVHHVAADGSSMGPLARDLMAAYVARVAGEAPQWTPLPVQYADYAL 10267 Query: 208 LSVEVLQNSAAP-SVA--DVGYWAETLRXXXXXXXXXGVSGANPCRRAQ-RRVR-PLPAG 262 EVL + P SVA V YW L P + + VR + Sbjct: 10268 WQREVLGSEDDPDSVAARQVAYWKSALAGLPDQLDLPSDRPRPPAQSFHGKAVRFDITPE 10327 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 L +R+ + AR +AS FMV+ A VL+ R +G D V P+ R L G F N Sbjct: 10328 LHARLHELARANNASLFMVVHTALAVLLARLSGTDDIAVGTPIAGRGERELDDLIGMFVN 10387 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLG 381 TL+ R D F + EVRE L FA+ V +R+V NP R V L Sbjct: 10388 TLVFRTQVEPGDRFADLLAEVRERDLEAFANADVPFERLVEVLNPVRSTARNPLFQVGLS 10447 Query: 382 F-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTI--ALDPDDVSVEFEYQQQLSSVLV 438 F N+ ++ LAL G+ V + +GA A L++T+ D D E ++ L Sbjct: 10448 FQNLAETT--LALPGLQVSAVDVGAQLAKTDLTVTLYDLYDEDGTPAEIVTDFSYATDLF 10505 Query: 439 DQMLVH-----YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEM-PATTMVK 492 D+ V ++++++ +A+ + P+ +D+L E + +L + + PA T+V Sbjct: 10506 DEATVQGFADRFVRVLETVVADMDVPVGEIDLLAPEEAERILRSWNDTAHPVDPAATLVS 10565 Query: 493 XXXXXXXXXXXXXXXXXVSDEA----ELTYSELHRRANRLARWFIGQGFGPEDIIGLRMA 548 V+D A ELT++EL R NRLAR I +G ED + L M Sbjct: 10566 LFDAALAAADPAAVAV-VADTAQGRVELTFAELDARVNRLARHLIARGVRTEDRVALAMR 10624 Query: 549 NSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRP----ELDVAERAA 604 S++ +V+M AV +AGAAY+PIDP P ER+ Y++ A P V+ E +V E A Sbjct: 10625 RSLDLVVSMYAVSRAGAAYVPIDPDQPAERVGYILETAAPAVVLTTTADAFETEVGEIVA 10684 Query: 605 ADNSDL------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVA 658 D DL P++D+DR L P AYVI+TSGSTGRPKGVAV H A+A + Sbjct: 10685 VDALDLSAVSAAPITDADRNGALLPATTAYVIFTSGSTGRPKGVAVPHGAVANQLCYIAE 10744 Query: 659 EWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTV 718 E+ + A+D L ++ +FD S+ + + + G +L+V D D +Y+ L+ GVT Sbjct: 10745 EFALGADDVVLLKTAATFDVSVWEFWSAVLTGGRLVVATADGHRDPAYLNALMRDTGVTT 10804 Query: 719 XXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVV 778 LR + GEALP A RF A L N YGPTEA V Sbjct: 10805 LYVVPSMLDALLIESGDRMPESLRRILAIGEALPAATAQRFRAANRAGLFNLYGPTEAAV 10864 Query: 779 C-STHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGR 837 +TH V A V IGVP N YVLD +L PVP V GELYL G+QLARGY R Sbjct: 10865 SITTHEVDDDDTVA--VSIGVPQWNSQVYVLDSRLRPVPVGVSGELYLAGAQLARGYFSR 10922 Query: 838 PTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVI 897 P LTA RF+A+PF G R+YRTGDLV GEL++ GR D QVKIRGFRIELGE+ES + Sbjct: 10923 PDLTADRFVANPFAVGERMYRTGDLVAWTADGELDYRGRTDFQVKIRGFRIELGEIESAL 10982 Query: 898 TTHPAVRHCLVVAE-ETEAGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGAFAVI 955 AV V+A + G L AY+VPA ++D ++ +A +P YMVP F + Sbjct: 10983 LKQDAVAAAAVLAHTDPNLGDRLVAYVVPATPGEIDTFALQTALSAEIPSYMVPSVFMQL 11042 Query: 956 PEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQ------RVGAE 1009 E+P+ V+GKLDR+ALP PT +R P T E+ + + FA++ G R+G + Sbjct: 11043 DELPLNVNGKLDRKALPEPT-FEKAVFRAPTTPIEQIVATTFAEVLGLDQSAGGARIGLD 11101 Query: 1010 DSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDN 1069 D FF GG+SLLA ++ +++ A + VR +F+APT A LA R VE+ L L Sbjct: 11102 DDFFAWGGNSLLATQVASRLGAALNTRVPVRLLFEAPTVAALAVR-VEQQAGTGRLAL-- 11158 Query: 1070 LAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPX 1129 ARP RP+R+PLS +Q WF R + +N+P+A+R G Sbjct: 11159 -----------TARP------RPERIPLSLAQQRMWFLNRFDTQSAAYNVPMAVRLTGEL 11201 Query: 1130 XXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQ-IVHPSRT-VQLAVRAIDQDEFDDVSTQ 1187 RHE LRT + +G P Q I+ P++ V LA RAI E ++ + Sbjct: 11202 DVTALRTAIADLIGRHEVLRTVYPAVDGDPVQLILSPAQAQVPLATRAIAAAEIENAVVE 11261 Query: 1188 LRRHVFTPESGPLLQANLLVLGP----DTHVLLLIVHHIVSDHASLEIVFDDLIVAYRAR 1243 L F ++ L + +V+ ++VHHI D +S + DL+ AY AR Sbjct: 11262 LVGQPFDVTDQVPVRVTLFEITDAGEVPEYVIAMVVHHIAGDGSSFAPLVRDLMTAYVAR 11321 Query: 1244 LQHNAPQWDILPIQFADYAVWQRNTFESNWGQT-----ELDYWRDALAGLPDEISVATDR 1298 AP W LP+Q+ADY++WQR S T +L YW+ ALA LP+++ + DR Sbjct: 11322 SMGEAPNWSPLPVQYADYSIWQRELLGSEDDPTSLMAGQLAYWKTALADLPEQLDLPADR 11381 Query: 1299 ARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALG 1358 RP RG V + A L + + AT FM+ ALAV+L +L G DIA+G Sbjct: 11382 PRPATQSFRGGAVPVRIDAETHRKLIAVGQAESATLFMVVHTALAVLLSRLSGADDIAIG 11441 Query: 1359 SPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLV 1418 +P+A R E A L+G F N +V R+ ++ +L R+ + A AH ++P ERLV Sbjct: 11442 TPIAGRGEAALNDLIGTFINTLVFRSRVAPGEPFDVLLARQREIDIQAFAHADVPFERLV 11501 Query: 1419 EALNPPRALSRNPLFQNMLNFRGE 1442 E LNP R+ +R+PLFQ L+F+ + Sbjct: 11502 EVLNPARSTARHPLFQVGLSFQNQ 11525 Score = 733 bits (1892), Expect = 0.0 Identities = 505/1433 (35%), Positives = 714/1433 (49%), Gaps = 100/1433 (6%) Query: 64 LNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRRED 123 +NI L G +D D L A + AR V+ +GEP+Q ++ D Sbjct: 3 INIAQYVDLRGDLDVDALERA-SAAAAREMGSGFLKIVERDGEPFQTVDFTLDATLEYVD 61 Query: 124 LTRLPEAGHERQIESLAAD----EFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICW 179 L + ES AA+ E+ RP D+ + +R +R HHI Sbjct: 62 LRDAEDP------ESAAAEWMRAEYSRPLDIVADRLIRAAALRLADSRWFWYSRAHHIAL 115 Query: 180 DDDSWEVFFGELSAAYN-DLPINDPAAQ-------FLSVEVLQNSAAPSVADVGYWAETL 231 D F ++ Y ++ +P+ E+ ++ +D +WAE + Sbjct: 116 DGFGAMTFMNRIAELYTAEVTGTEPSPAKATDLKTLYESEIAYRDSSRFESDKQHWAERV 175 Query: 232 RXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVR 291 G S A P L + + + + + SP +L+AA+ + Sbjct: 176 AGLEEGSSLAGRS-APPAPVNGVTSAALSSEQDALLTEAVARHDNSPAGLLIAAFATYLA 234 Query: 292 RYTGASDFLVSVPVTERSGAA-AGALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGF 350 + TGA D ++S+PVT R+ AA + G N + LR+ T + V+ Sbjct: 235 QMTGAEDVILSLPVTARTTAAMRRSGGAVSNIVPLRLRVAHDTTVAELLKSVQVEVSGAL 294 Query: 351 AHQSVGIDRVVREANPERMGRDGMDLLVRLG--FNMRKSAGGLALDGVV--VRQLGLGAV 406 HQ + + R+A DG+ G N+ + L +V + L G++ Sbjct: 295 RHQRYRHEDIRRDA-----AGDGVVTTEFFGPWVNIMLFHSEMTLGPMVGQLHVLSTGSI 349 Query: 407 AAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVH---YLQLVDKAL-AEPERPLSS 462 L ++ ++ ++FE L S ++ H +L+ D+ L A+ + Sbjct: 350 -EDLGVNFYQSVAGSRSHIDFETNPNLYS--AEEAAAHHGRFLEFFDRFLAADAAAKVWE 406 Query: 463 LDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELH 522 L ++ A ER+ L + + ++P TT+V + A LTY+E Sbjct: 407 LPVVTAAERERTLVEWNDSAQDVPDTTLVALLDAQIPRTPDRIALDF--EGATLTYAEFD 464 Query: 523 RRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYL 582 R NRLAR+ I G GPE ++ L M S+E ++ M AVLKAG AY+PIDP +P ER Y+ Sbjct: 465 ERVNRLARFLIADGVGPESLVALGMRRSLELVIGMHAVLKAGGAYVPIDPDHPAERTAYI 524 Query: 583 ITDARPQTV--IGRPELDVAE---RAAADNSDL------PLSDSDRLRPLRPGHLAYVIY 631 ++ A P V + EL++ E R D D+ PL+D+DR PLRP + AYVIY Sbjct: 525 LSSADPVCVLTVSGDELELPESVRRVEIDTLDVSAYSPQPLTDADRRAPLRPENTAYVIY 584 Query: 632 TSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGA 691 TSGSTGRPKGVAV+HHAI + E+ +TA+D +LQ ++ +FD SL F+ L +GA Sbjct: 585 TSGSTGRPKGVAVTHHAIVNQQLWMLDEYRLTADDVYLQKTATTFDVSLWGYFLPLMVGA 644 Query: 692 QLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEAL 751 +L++ PD D YVAD+I+R VTV Q + LR V V GEAL Sbjct: 645 KLVIAAPDGHRDPLYVADMIARHRVTVTDFVPSMLTVFVAHATPAQVQSLRAVFVIGEAL 704 Query: 752 PGEVADRFAGYF--DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLD 809 P E A +F A L N YGPTEA V T+ T + VPIG+P NV YVLD Sbjct: 705 PPETAAQFRALTADGAGLHNLYGPTEAAVSVTYWEATAADTV-TVPIGIPEWNVEVYVLD 763 Query: 810 EQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHC 868 +L P GELYLGG QLARGY GRP LT+ RF+A+PF P G R+YRTGDLVR N Sbjct: 764 SRLRPAAIGAPGELYLGGRQLARGYRGRPDLTSDRFVANPFGPAGSRMYRTGDLVRWNAA 823 Query: 869 GELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAAA 928 G LE++GR D QVK RG RIELGE+E+V HPAV V+ +T G L AY+VPA Sbjct: 824 GTLEYIGRTDFQVKFRGQRIELGEIETVTLAHPAVSQSAVLVVDTATGQQLVAYVVPAPG 883 Query: 929 Q-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPET 987 Q +D E+ A +P YMVP + V+ P+ SGKLDR+ALP P A YR P T Sbjct: 884 QSIDPLELTRFAAEHLPSYMVPASVMVLDAFPLNTSGKLDRKALPEPVFAADAGYRAPRT 943 Query: 988 ATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPT 1047 E+ + +IFA + + RVG +D+FF LGG+SL+A ++VA+I A FG + VR +F+ PT Sbjct: 944 QAEQIVANIFADVLSQDRVGIDDNFFDLGGNSLVATQVVARIGAAFGTQIGVRALFETPT 1003 Query: 1048 PAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQ 1107 AG+AAR + + RP V P R+PLS +Q WF Sbjct: 1004 VAGIAARA------------------EHAAPAEGGRPPLVAQELPDRVPLSLAQQRMWFI 1045 Query: 1108 YRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSR 1167 + + +N+P +R G R E+LRT F E YQ V P Sbjct: 1046 NQFDPTAPTYNLPFVVRLRGNVDIAALKAALNDVMARQESLRTIFPESGDGGYQQVIPDD 1105 Query: 1168 TVQL--AVRAIDQDEFD-----------DVSTQL--RRHVFTPESGPLLQANLLVLGPDT 1212 + L AV++ID+ E DV+ +L R +F G G Sbjct: 1106 EINLAIAVQSIDESELPATLAEFAATGFDVARELPIRVRIFRVTGGS-------TNGTPD 1158 Query: 1213 HVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES- 1271 H + +VHHI +D S + D+ AY AR APQW LP+Q+ DY++WQR S Sbjct: 1159 HAVAFVVHHIAADGFSFGPLSRDVAAAYLARAAGEAPQWAPLPVQYQDYSIWQRELLGSE 1218 Query: 1272 ----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLA 1327 + ++ YWR LAGLPD++ + TDR RP V RG F + A A L QLA Sbjct: 1219 SDPESMAARQIAYWRRQLAGLPDQLELPTDRPRPPVQSFRGATTHFEIDAELHAELAQLA 1278 Query: 1328 ERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLS 1387 G + FM+ AALAV++ +L G TD+A+G+P+A R E A L+G+F N +VLR+D+ Sbjct: 1279 RAQGVSLFMVVHAALAVLMGRLSGTTDVAIGTPIAGRGEQALDDLIGMFVNTLVLRSDVD 1338 Query: 1388 GDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 G L +R+T L A AH ++P ERLVE LNP R+ +R+PLFQ ML+F+ Sbjct: 1339 GGQPFTEFLARTRETDLQAFAHADVPFERLVEVLNPTRSQARHPLFQVMLSFQ 1391 Score = 728 bits (1880), Expect = 0.0 Identities = 519/1457 (35%), Positives = 709/1457 (48%), Gaps = 87/1457 (5%) Query: 44 LSDGQRRMWFLQTMD--PDD----VTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRT 97 LS Q+RMWFL D PD T NI A RL GL+D L AV DVVARH LRT Sbjct: 3185 LSLAQQRMWFLNRFDTGPDAGGAASTYNIPAAVRLRGLLDVAALRGAVADVVARHETLRT 3244 Query: 98 TYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGR-------PFDL 150 Y EG YQ +PE +E+ D GR FD+ Sbjct: 3245 VYP-SHEGVAYQRVLPAARA---------IPEVD---VVETAEQDLLGRLYDFVNAGFDV 3291 Query: 151 TNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDPA- 204 T E P+R+ + + VL LVVHHI D S +L AY N P P Sbjct: 3292 TAEPPVRLRIYELGERDYVLALVVHHIAADGFSMRPLVRDLMTAYVARTGNTEPGWSPLD 3351 Query: 205 AQFLSVEVLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPC--RRAQR 254 Q++ + Q D + YW L N R Sbjct: 3352 VQYIDFALWQRETLGDEDDPTSLIAQQLDYWRTALADLPDELRLVHKPRPNVASYRAGTH 3411 Query: 255 RVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 R R +P L R+ A + FMV+ A+ L+ R +GA D + +PV R A Sbjct: 3412 RFR-VPGELIDRLNRVAHANGTTLFMVVHGAFATLLSRLSGADDIAIGIPVAGRGEQALD 3470 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 L G F NTL+LR + FT + +VRE LA FAH V +R+V NP R Sbjct: 3471 DLVGMFVNTLVLRTQVDTATPFTDLLAQVRERDLAAFAHADVPFERLVEVLNPARSQARH 3530 Query: 374 MDLLVRLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPD---DVSVEFEY 429 V L F N+ +++ L L G+ V +LG+ A L LT++ P ++ E Y Sbjct: 3531 PLFQVMLSFQNLGRTS--LELPGLTVEELGIDPPTAKFDLQLTLSEIPGAEAEMDAELVY 3588 Query: 430 QQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQ-SHGELVEMPA 487 L + D +L+++ A P + +++L ER+ VL + + E A Sbjct: 3589 ATDLFDAGYADAFAARFLRVLHGVAAAPTAAVGDIELLDTAERELVLRRWNDTEFAVDAA 3648 Query: 488 TTMVKXXXXXXXXXXXXXXXXXVSDE-------AELTYSELHRRANRLARWFIGQGFGPE 540 T D LTY+E R +RLARW G GPE Sbjct: 3649 LTSPVGDSAATLVALFEAQVARTPDAVALTFEGTSLTYAEFASRVHRLARWLKDNGVGPE 3708 Query: 541 DIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-GRPELDV 599 + L + S++ +V M A+ AG AY+PIDP P ERI++++ A P V+ +LDV Sbjct: 3709 SYVALGIRRSLDLLVGMYAISAAGGAYVPIDPDNPAERIEHILETAGPVCVLTSGSDLDV 3768 Query: 600 --AERAAADN------SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAE 651 + + D SD PL+D+DR RPLR G+ AYVI+TSGSTGRPKGVAVSH AI Sbjct: 3769 TLSRQVRIDRLDLSGYSDAPLTDADRHRPLRTGNTAYVIFTSGSTGRPKGVAVSHAAIVN 3828 Query: 652 HVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLI 711 + A++ + A+D LQ + +FD S+ + F L +GA+L++ KPD D SY+A LI Sbjct: 3829 RLVWGHAQYGLAADDVVLQKTPATFDVSVWEFFWPLQVGARLVIAKPDGHRDPSYLAQLI 3888 Query: 712 SRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHY 771 +T + LR+V GE LP A R A L N Y Sbjct: 3889 IDEHITTAHFVPSMMSLFVVEPRAAECTGLRNVFASGEGLPAVTAQRLRELTGARLHNLY 3948 Query: 772 GPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLA 831 GPTEA V T VT + VPIG P N YVLD +L PVP V GELYL G+QLA Sbjct: 3949 GPTEAGVEVTFHEVTDADTV-TVPIGAPVFNTQVYVLDSRLRPVPVGVPGELYLAGAQLA 4007 Query: 832 RGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELG 891 GY+ RP LT +RF+ADPF G+R+YRTGDLV GELE++GR D QVK+RG RIELG Sbjct: 4008 YGYVTRPDLTTERFVADPFGHGVRMYRTGDLVAWTADGELEYLGRTDFQVKLRGLRIELG 4067 Query: 892 EVESVITTHPAVRHCLVVAEETE-AGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVP 949 E+E +T PAV +VV E G L AYL+ +D++ ++A + +P YMVP Sbjct: 4068 EIEGALTALPAVSQSVVVVRHDERTGDQLVAYLIAEPNYTIDVDAVKAALSTQLPAYMVP 4127 Query: 950 GAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAE 1009 AF V+ P+ SGKLDR+ALP PT + ++ P T ++ + S F + G RVG + Sbjct: 4128 AAFVVLDAFPLNASGKLDRKALPEPT-FEAKTFQAPVTPVQQIVASAFGDVLGIDRVGLD 4186 Query: 1010 DSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDN 1069 D FF LGG+SL+A +L A++ A + +RT+F+A T A LAA++ Sbjct: 4187 DDFFALGGNSLVATQLTARLGAALDTQIPLRTLFEASTVAALAAKVESATGQGGRAP--- 4243 Query: 1070 LAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPX 1129 L A + P A Q +PLS +Q WF R + N+P+A+R G Sbjct: 4244 LTAQERP-----APVPLPDGQTAQLVPLSPAQQRMWFLNRFDNRTGVNNIPVAVRLTGAL 4298 Query: 1130 XXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPS--RTVQLAVRAIDQDEFDDVSTQ 1187 RHE LRT + E +G YQ V P+ V L + E + Sbjct: 4299 DAAALQAAIRDVVARHETLRTVYPEVDGEGYQRVLPADEAPVDLVTEWVPASEAPRRVVE 4358 Query: 1188 LRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHN 1247 L F + +A LL L +++L+L++HHI +D SL + D++VAY R+ Sbjct: 4359 LASTWFDVTAEIPFRATLLTLDERSNLLVLVMHHISADGFSLRPLLRDIVVAYTERVGGE 4418 Query: 1248 APQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPR 1302 AP W L +Q+ADY +WQR + ++ YW + L LPD+I + DR RP Sbjct: 4419 APNWAPLEVQYADYTLWQRGVLGAEDDPESVAAAQIAYWIEQLRDLPDQIELPADRPRPE 4478 Query: 1303 VLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVA 1362 V G + F+V A AL +A +G T FM+ AALA +L TDIA+G+P+A Sbjct: 4479 VASNAGALHHFTVDAQLHRALEDVARAHGVTLFMVVHAALATWAARLSNSTDIAIGTPIA 4538 Query: 1363 ARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALN 1422 R E A LVG+F N +VLR ++ +L R T L A AH ++P ERLV+ L+ Sbjct: 4539 GRGERALDDLVGMFVNTLVLRNEIDLGAKFSDLLEQVRRTDLAAFAHADVPFERLVDVLS 4598 Query: 1423 PPRALSRNPLFQNMLNF 1439 P R+ + +PLFQ L F Sbjct: 4599 PARSQAHHPLFQVGLTF 4615 Score = 727 bits (1877), Expect = 0.0 Identities = 513/1472 (34%), Positives = 735/1472 (49%), Gaps = 108/1472 (7%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+RMWFL D NI VA RL G +D L A+ DVVARH LRT Y + Sbjct: 4266 LSPAQQRMWFLNRFDNRTGVNNIPVAVRLTGALDAAALQAAIRDVVARHETLRTVYP-EV 4324 Query: 104 EGEPYQ--VFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVI 161 +GE YQ + +D+ V E +P + R++ LA+ F D+T E+P R T++ Sbjct: 4325 DGEGYQRVLPADEAPVDLVTE---WVPASEAPRRVVELASTWF----DVTAEIPFRATLL 4377 Query: 162 RTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVL-------- 213 +L+LV+HHI D S ++ AY + + A + +EV Sbjct: 4378 TLDERSNLLVLVMHHISADGFSLRPLLRDIVVAYTER-VGGEAPNWAPLEVQYADYTLWQ 4436 Query: 214 -------QNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP-------- 258 + + + A + YW E LR P R + V Sbjct: 4437 RGVLGAEDDPESVAAAQIAYWIEQLRDLPDQIEL-------PADRPRPEVASNAGALHHF 4489 Query: 259 -LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL- 316 + A L +ED AR + FMV+ AA R + ++D + P+ R A L Sbjct: 4490 TVDAQLHRALEDVARAHGVTLFMVVHAALATWAARLSNSTDIAIGTPIAGRGERALDDLV 4549 Query: 317 GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDL 376 G F NTL+LR F+ + +VR T LA FAH V +R+V +P R Sbjct: 4550 GMFVNTLVLRNEIDLGAKFSDLLEQVRRTDLAAFAHADVPFERLVDVLSPARSQAHHPLF 4609 Query: 377 LVRLGFNMRKS--AGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD-VSVEFEYQQQL 433 V L F + AG ++L G+ + + A A + LT+ +++ + Y +L Sbjct: 4610 QVGLTFEAASATEAGTVSLPGLDLDIVDFDAGTAKFDVQLTVGEAAGGALAMSWNYATEL 4669 Query: 434 SSVLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVL-----AQSHGELVEMPA 487 L + +++AE P + +D+LG ER V A + G Sbjct: 4670 FDPETVAAFADRLVRILRSVAEDPAVVVGDIDLLGEPERLDVAQRWVSAGADGGAARFAD 4729 Query: 488 TTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRM 547 T+V +D LTY+EL RRAN LAR I G GPE ++ + + Sbjct: 4730 ATLVSLFDEMAAAHPEQVAAKFGADA--LTYAELDRRANVLARRLIEDGAGPEKLVAVLL 4787 Query: 548 ANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-----------GRPE 596 S++ +VA+LAV+K GA Y+PIDPAYP ERI Y++ DARP +V+ G P Sbjct: 4788 PRSLDLVVALLAVVKTGAGYVPIDPAYPAERIAYVLADARPASVVLDSTVEAEIPAGLPG 4847 Query: 597 LDVAERAA-----ADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAE 651 + V AD D P++D+DRL PL P ++AYVIYTSGSTGRPKGVAV+H + Sbjct: 4848 ITVDGFGVETGDMADADDAPITDADRLAPLSPDNVAYVIYTSGSTGRPKGVAVAHRNVVR 4907 Query: 652 HVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLI 711 + ++ +D W F S +FD S+ +++ L G ++V +L+ Sbjct: 4908 LLANTDRDFGFGPQDVWTLFHSYAFDFSVWELWGPLSFGGTVVVVDYYTSRSPEQFLELL 4967 Query: 712 SRRGVTVXXXXXXXXXXXXXXXXXXQ----WRQLRHVPVGGEALP-GEVADRFAGYFDAE 766 VTV LR+V GGEAL ++D A + DA Sbjct: 4968 RAERVTVLNQTPSAFYQLAEADRTAAPGAARLSLRYVVFGGEALELRRLSDWVARHGDAS 5027 Query: 767 --LRNHYGPTEAVVCSTHMVVTGSHGARVVP--IGVPNRNVYAYVLDEQLHPVPDQVIGE 822 L N YG TE V ++ + + A +G + YVLD +L PVP V GE Sbjct: 5028 PVLVNMYGITETTVHVSYRALDAATIASASGSIVGRAIAGLRVYVLDNRLRPVPVGVAGE 5087 Query: 823 LYLGGSQLARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQV 881 +Y+ G QLARGYLGRP LTA RF+A+P G RLYR+GDL R N GELE++GRAD+QV Sbjct: 5088 MYVAGPQLARGYLGRPDLTAARFVANPLGEAGERLYRSGDLARWNRFGELEYLGRADDQV 5147 Query: 882 KIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAAAQV-DLEEIRAHT 939 K+RGFRIELGE+E+ + P + V+ E + G + AY+V DL+ +R+ Sbjct: 5148 KVRGFRIELGEIEAAVLAQPGIAQAAVIVREDQPGDQRIVAYVVAEPGVTPDLDAVRSGA 5207 Query: 940 AAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQ 999 A +P YMVP A + IP+TV+GKLDRRALPAP + + +R P T + + ++FA+ Sbjct: 5208 AEQLPSYMVPSALVRLEWIPLTVNGKLDRRALPAPA-VQAKAFRAPVTPVQETVAAVFAE 5266 Query: 1000 LFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERF 1059 + RVG +D FF LGG+SL+A R+ A+I A G + VRT+F+A T LAAR+ Sbjct: 5267 VLDVPRVGVDDDFFELGGNSLIATRVAARIGAALGTTVPVRTLFEASTVEALAARVESHT 5326 Query: 1060 RNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNM 1119 P AR A + +PLS++Q WF + + + +N+ Sbjct: 5327 GG-----------------PAVARLAARPRAAGELVPLSYAQQRMWFLNKYDTSSAAYNL 5369 Query: 1120 PLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVR--AID 1177 P+A+R G RHE+LRT + EH G P Q+V P+ +++ + A+ Sbjct: 5370 PIAIRLTGALDVPALRLALADVVRRHESLRTRYPEHGGTPVQVVVPAEQIEIDLHPVAVA 5429 Query: 1178 QDEFDDVSTQLRRHVF-TPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDL 1236 DE + T+ F E PL V G D HVL+++VHHI +D S+ + D+ Sbjct: 5430 ADELLETVTEFVGTGFDVAEEVPLRTRLYAVSGADEHVLVVVVHHIAADGFSMGPLTRDV 5489 Query: 1237 IVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTEL-----DYWRDALAGLPDE 1291 + AY AR Q P W LP+Q+AD+A+WQR + L YW+ ALAG+PDE Sbjct: 5490 MTAYGARTQGAVPGWAPLPVQYADFALWQREVLGAEDDPESLLARQVAYWQRALAGVPDE 5549 Query: 1292 ISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGG 1351 +++ TDR RP V RG + +PA AL +A R+GA+ FM+ ALAV+L +L G Sbjct: 5550 LTLPTDRPRPAVASHRGATLSAELPAELIRALDDVARRHGASLFMVMHGALAVLLARLSG 5609 Query: 1352 GTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQE 1411 DI +G+P+A R E A +LVG+F N +VLRT + ++L R T LDA + + Sbjct: 5610 SDDITVGTPIAGRGEAALDELVGMFVNTLVLRTGIDEAEPFTALLDRVRRTDLDAYGNAD 5669 Query: 1412 LPIERLVEALNPPRALSRNPLFQNMLNFRGED 1443 +P ERLVE L P R+ +RNPLFQ ML F+ D Sbjct: 5670 VPFERLVELLAPERSQARNPLFQVMLAFQNLD 5701 Score = 693 bits (1789), Expect = 0.0 Identities = 506/1423 (35%), Positives = 695/1423 (48%), Gaps = 94/1423 (6%) Query: 72 LAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAG 131 L G VD RL A V+ R+ LRT + D +G QV D V V W D R Sbjct: 6930 LTGHVDPARLRAAAQAVLDRYENLRTAFLTDHDGNAVQVVLDGVRVNWSEHD--RRDTGA 6987 Query: 132 HERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGEL 191 E IE AD R FDL +R T+IR ++ HHI D S + +L Sbjct: 6988 AEDLIE---ADRMHR-FDLAAPPLIRFTLIRVGEQRWEFVVSNHHILLDGWSMPLLMRDL 7043 Query: 192 SAAYND------LPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGV-S 244 Y LP FL Q++AA A W + LR + Sbjct: 7044 LMLYATHADAAALPAVRSYRHFLEWAAQQDTAASLAA----WRDALRGVTEPTLLARADA 7099 Query: 245 GANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVP 304 G + + L +R+ + A +P VL A+G+LV R G+ D L Sbjct: 7100 GREITALSGEYLFDLDEAATARLTELASSLGVTPNTVLQVAWGILVGRMAGSEDVLFGTT 7159 Query: 305 VTERSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVV 361 V+ R AG +G F NT+ +R+ + ++ + V+ H VG+ + Sbjct: 7160 VSGRPAQLAGVESMVGLFINTVPVRVRFDAAESVRELLTRVQGEQADLLDHHYVGLADIQ 7219 Query: 362 REANPERMGRDGMDLLVRLGFNMRKSAGGLA----LDGVVVRQLGLGAVAAHLPLSLTIA 417 A + D LV + G A +DG+ V + A A H PL+L Sbjct: 7220 SAAGVGAL----FDTLVVFESYPVDAEGIQAQAADIDGMAVAGIE-AADATHYPLTLIAQ 7274 Query: 418 LDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVL- 475 LD + + Y + L V ++ ++++ A+P + +D+L A ERD V+ Sbjct: 7275 LD-SRLRIRAGYLRDLFDEPTVRRIADRLVRVLTTISADPAVAVGDIDLLDATERDLVVS 7333 Query: 476 ---AQSH--------GELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRR 524 A +H GEL A T+V + L+Y+E R Sbjct: 7334 GWNATAHPIEPAALLGELAGTSALTLVSMFEAQVARTPDAPALTF--EGTGLSYAEFAAR 7391 Query: 525 ANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLIT 584 +RLARW I +G GPE + L M SI+ +V M AV AG AY+P+DP +P ER +Y++ Sbjct: 7392 VHRLARWLIQRGVGPESYVALGMRRSIDLVVGMYAVSVAGGAYVPLDPDHPAERTEYILA 7451 Query: 585 DARPQTVIGRPE---LDVAERAAADNSDL------PLSDSDRLRPLRPGHLAYVIYTSGS 635 A P V+ + +D A+ D DL P++D++R PLRP + AYVI+TSGS Sbjct: 7452 TADPVCVLTSGDDLPIDTAQ-VRIDLLDLDGLSEAPVTDAERRMPLRPENTAYVIFTSGS 7510 Query: 636 TGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIV 695 TGRPKGVAVSH AI + AE+ +TA D LQ + +FD S+ + F L +GA+L+V Sbjct: 7511 TGRPKGVAVSHAAIVNRLVWMQAEYGLTAADAVLQKTPATFDVSVWEFFWPLQIGARLVV 7570 Query: 696 PKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEV 755 KPD D +Y+A++IS VTV + LR V GEALP + Sbjct: 7571 AKPDGHRDPAYLAEVISAERVTVTHFVPSMLAVFVADAAAARCDALRMVFASGEALPPKP 7630 Query: 756 ADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPV 815 A R AEL N YGPTEA V T+ VT + VPIG P N YVLD +L P Sbjct: 7631 AHRLRELTGAELHNLYGPTEAAVDVTYHRVTDAD-IDTVPIGAPVFNTQVYVLDARLRPA 7689 Query: 816 PDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVG 875 P V GELYL G+QLARGY+ RP LTA RF+ADPF G R+YRTGDLV GELE++G Sbjct: 7690 PVGVAGELYLAGAQLARGYVARPDLTADRFVADPFGDGQRMYRTGDLVAWTAEGELEYLG 7749 Query: 876 RADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVPA-AAQVDLE 933 R D QVK+RG RIELGE+ES +T + +VV + G L AY+VPA AQVD + Sbjct: 7750 RTDFQVKLRGLRIELGEIESALTALEEIAQAVVVVRGDQRTGDQLVAYVVPAPGAQVDSD 7809 Query: 934 EIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWI 993 +R +P YMVP + P+ SGKLDR+ALPAP +R P T E + Sbjct: 7810 LVREDLGRQLPAYMVPALVMALDAFPLNASGKLDRKALPAPV-FEAAVFRAPTTPVEEIV 7868 Query: 994 CSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAA 1053 FA + G +RVG +D FF LGG+SL A ++ A++ A +L VR +F+A T A LAA Sbjct: 7869 ARTFADVLGVERVGLDDDFFALGGNSLSATQVAARLSAALETELGVRELFEASTVAALAA 7928 Query: 1054 RLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIE-- 1111 R AR V RP+R+PLS +Q WF R Sbjct: 7929 RAETG-------------------AGAGARAALVPQRRPERVPLSLAQQRMWFLNRFNIG 7969 Query: 1112 -GAREE------FNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVH 1164 G E N+P A+R G RHE+LRT + E GV YQ V Sbjct: 7970 TGGGEHNLAAAADNIPAAVRLSGLLDRQALQVAVADVLARHESLRTYYPEIGGVGYQQVV 8029 Query: 1165 PSRTV--QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHI 1222 P+ V LA I + E + L F + +A L + P HVL L+VHHI Sbjct: 8030 PTAQVIPDLAPIEITEAELPERIADLVLTAFDVTAEVPFRARLFEISPTEHVLALVVHHI 8089 Query: 1223 VSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTE 1277 +D S+ + D+++AY AR++ + P W L IQ+ADYA+WQR+ + + Sbjct: 8090 SADGFSMGPLTRDVMIAYSARVEGDEPAWRPLEIQYADYALWQRDVLGAEDDPESLIARQ 8149 Query: 1278 LDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFML 1337 + +W+ L GL +++ + TDR RP V RG V F+V A L LA + +T FM+ Sbjct: 8150 IAFWQRELGGLVEQLDLPTDRPRPAVASNRGATVGFTVDPEVHAGLRGLAADHNSTLFMV 8209 Query: 1338 YQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILV 1397 AALAV+L +L G DIA+G+P+A R E A L+G+F N +VLRT++ +L Sbjct: 8210 VHAALAVLLARLSGTRDIAIGTPIAGRGERALDDLIGMFVNTLVLRTEIDPGVAFDDLLR 8269 Query: 1398 GSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 R +DA H ++P ERLVE L+P R+ R+PLFQ L F+ Sbjct: 8270 TVRRVDVDAFGHADVPFERLVEVLDPVRSPGRHPLFQVALTFQ 8312 Score = 672 bits (1734), Expect = 0.0 Identities = 507/1480 (34%), Positives = 713/1480 (48%), Gaps = 111/1480 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDD---------VTLNICVAYRLAGLVDEDRLHTAVNDVVA 90 ER LS Q+RMWFL + NI A RL+GL+D L AV DV+A Sbjct: 7949 ERVPLSLAQQRMWFLNRFNIGTGGGEHNLAAAADNIPAAVRLSGLLDRQALQVAVADVLA 8008 Query: 91 RHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDL 150 RH LRT Y + G YQ +V DL P E ++ AD FD+ Sbjct: 8009 RHESLRTYYP-EIGGVGYQQVVPTAQV---IPDLA--PIEITEAELPERIADLVLTAFDV 8062 Query: 151 TNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAA----- 205 T E+P R + E VL LVVHHI D S ++ AY+ D A Sbjct: 8063 TAEVPFRARLFEISPTEHVLALVVHHISADGFSMGPLTRDVMIAYSARVEGDEPAWRPLE 8122 Query: 206 -QFLSVEVLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRV 256 Q+ + Q + D + +W L P + R Sbjct: 8123 IQYADYALWQRDVLGAEDDPESLIARQIAFWQRELGGLVEQLDLP-TDRPRPAVASNRGA 8181 Query: 257 R---PLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA 313 + + + + A +++ FMV+ AA VL+ R +G D + P+ R A Sbjct: 8182 TVGFTVDPEVHAGLRGLAADHNSTLFMVVHAALAVLLARLSGTRDIAIGTPIAGRGERAL 8241 Query: 314 GAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRD 372 L G F NTL+LR F + VR + F H V +R+V +P R Sbjct: 8242 DDLIGMFVNTLVLRTEIDPGVAFDDLLRTVRRVDVDAFGHADVPFERLVEVLDPVRS--P 8299 Query: 373 GMDLLVRLGFNMRKSAGG-LALDGVVVRQLGLGAVAAHLPLSLTIA--LDPDD----VSV 425 G L ++ + + L L G+ V + + A L LT+ + D ++ Sbjct: 8300 GRHPLFQVALTFQNTGPAELELPGLTVSPVDMAVPLAKFDLQLTLEEKVGADGAAAGMAA 8359 Query: 426 EFEYQQQLSSVLVDQMLVHYLQLVDKAL-AEPERPLSSLDILGAGERDSVLAQSHGELVE 484 EF Y L + LQ + A+ A + +D+L GERD VL + VE Sbjct: 8360 EFGYATDLFDESTIREFADRLQRIMAAVTANASAVVGDIDLLAPGERDLVLRAWNTPGVE 8419 Query: 485 MPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIG 544 +P TMV + L++ E+ RRANR+AR I +G GPE + Sbjct: 8420 VPEVTMVDLIAAQAARRPDADAIRF--GDTALSFGEMQRRANRIARTLIDRGVGPESRVA 8477 Query: 545 LRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGR-------PEL 597 + ++ + VA+ AVL GAAY+P+D YP +R+++++TDA P V+ P + Sbjct: 8478 VAVSRTEHLPVALYAVLLTGAAYVPVDTTYPVQRLEFMLTDAAPVCVLTTAADADAVPAV 8537 Query: 598 DVA----ERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHV 653 DV E+AA SD P++D+DR PLRP +LAYVIYTSGSTG PKGV V+H + Sbjct: 8538 DVPVVLLEQAATAGSDAPVTDADRRAPLRPDNLAYVIYTSGSTGVPKGVGVTHRDAVQLF 8597 Query: 654 QGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISR 713 + D W F S +FD S+ +++ L G ++V +L+ R Sbjct: 8598 ANTQPLFGFDESDVWTLFHSYAFDFSVWELWCALAYGGSVVVVDYLTSRSPELFRELLVR 8657 Query: 714 RGVTVXXXXXXXXXXXXXXXXXXQWRQ------LRHVPVGGEALPGEVADRFAGYFDAE- 766 VTV LR++ GGEAL R+ A+ Sbjct: 8658 ERVTVLNQTPSAFYQLVEADRAASAAADAGEFALRYIVFGGEALDLRQLRRWYERHPADA 8717 Query: 767 --LRNHYGPTEAVVCSTHMVVTGS---HGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIG 821 L N YG TE V + + + + A V+ +P + AYVLDE+L P P V G Sbjct: 8718 PRLVNMYGITETTVHVSFLSLDEQVVDNPASVIGRALPGLS--AYVLDERLAPAPVGVAG 8775 Query: 822 ELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCG---ELEFVGRA 877 E+Y+ G QLARGYLGRP LTA RF+A+PF PG R+YR+GD+ R G LE+ GR+ Sbjct: 8776 EIYVTGEQLARGYLGRPGLTASRFVANPFGAPGSRMYRSGDVGRWVGFGGAANLEYAGRS 8835 Query: 878 DEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE-AGPMLAAYLVP-AAAQVDLEEI 935 D+QV++RGFRIELGE+E+ + VR +V+ E AG L Y+VP A VD + Sbjct: 8836 DQQVQLRGFRIELGEIEAALEQCDGVRQAVVMVRADEHAGDRLVGYVVPDTGAAVDPVAV 8895 Query: 936 RAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICS 995 R A + YMVP A V+ +P+T +GKLDRRALP P ++T +R P T E+ + Sbjct: 8896 REQVARFLTAYMVPDAIVVLDTLPLTPNGKLDRRALPEPEFVSTATFRAPSTPIEQAVAR 8955 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +FA+L G VG +D FF LGG+SLLA R+VA+I L VR +F+APT A LAAR Sbjct: 8956 VFAELLGVDEVGLDDDFFALGGNSLLATRVVARINEAVDAGLAVRELFEAPTVAALAAR- 9014 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 AD + +RA V RP+R+PLS +Q WF R + A Sbjct: 9015 ---------------TADQVGTGRRRA---LVAGPRPERIPLSLAQQRMWFLNRFDSATA 9056 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEH-EGVPYQIVHP--SRTVQLA 1172 N+PLA+R G RHE LRT + E +G Q++ P S T+ L Sbjct: 9057 VNNIPLAVRMVGELDIEALRQAVADVIDRHEVLRTVYPETADGQGVQVILPAGSHTLDLH 9116 Query: 1173 VRAIDQDEFDDVSTQLRRHVF-TPESGPLLQANLLVLG------PDTHVLLLIVHHIVSD 1225 +++ E + ++L F +S P+ A V G P THVL+ +VHH+ D Sbjct: 9117 PIVVEEAELTERVSELVLTGFDVTQSVPVRAALFRVAGSMDGSQPPTHVLVFVVHHVSGD 9176 Query: 1226 HASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTEL-----DY 1280 S+ + D++VAY AR + AP W LP+Q+ADYA+WQR+ S L Y Sbjct: 9177 GWSVGPLARDVMVAYAARSRGEAPGWAPLPVQYADYAIWQRDVLGSEDDPDSLISEQVAY 9236 Query: 1281 WRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQA 1340 W LAGLPD++ + DR RP V RG V +F + A A L +L +GA+ FM+ A Sbjct: 9237 WSRQLAGLPDQLDLPADRKRPAVASNRGGVYEFGLDDALVAELDELGRAHGASLFMVVHA 9296 Query: 1341 ALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSR 1400 A A +L +L G DIA+G+ VA R E A +G+F N +VLR+ + + +L R Sbjct: 9297 AFAALLARLSGSDDIAVGTVVAGRGEAALDDAIGMFVNTLVLRSAVDPAESFTDLLTRIR 9356 Query: 1401 DTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 +T L A H +LP ERLVE LNP R+ +R+PLFQ ML+F+ Sbjct: 9357 ETDLAAFGHADLPFERLVELLNPARSQARHPLFQVMLSFQ 9396 Score = 552 bits (1423), Expect = e-154 Identities = 475/1436 (33%), Positives = 647/1436 (45%), Gaps = 138/1436 (9%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTL-NICVAYRLAGLVDEDRLHTAVNDVVARHAILRTT 98 ER LS Q R WFL DP + N+ A RL G +D L AV D+ ARH +LRT Sbjct: 12234 ERIPLSPAQARYWFLNQFDPSASAVDNVPFAVRLTGALDVSALERAVADIFARHEVLRTV 12293 Query: 99 YGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRI 158 Y +GEP QV + G L P E ++ + D FD+T E+PL++ Sbjct: 12294 YPT-VDGEPVQVV---LPAGQATPSLR--PVEITESELIATVIDFVLTTFDVTAEVPLKV 12347 Query: 159 TVIR-----------TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN----------- 196 + R T ++ V+ V HH+ D S +L AY Sbjct: 12348 ALFRIADSAAPAQHPTAPEQHVIAFVAHHVSADGASMGPLARDLMTAYMARAAGEAPQWA 12407 Query: 197 DLPINDPAAQFLSVEVLQNSAAP-SVA--DVGYWAETLRXXXXXXXXXGVSGANPCR--R 251 LP+ EVL P SVA V YW L P + R Sbjct: 12408 PLPVQYADYALWQREVLGTEDDPESVAAQQVAYWKSALAGLPDQLELPADRPRPPVQSFR 12467 Query: 252 AQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA 311 + L +R+ + AR +AS FMV+ AA VL+ R +G D V P+ R Sbjct: 12468 GSAVRFEIDPALHARLHEVARANNASLFMVVHAALAVLLARLSGTDDIAVGTPIAGRGER 12527 Query: 312 AAG-ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMG 370 +G F NTL+ R R D FT + EVRE L FAH V +R+V NP R Sbjct: 12528 ELDDMIGMFVNTLVFRTQVRPGDAFTDLLAEVRERDLQAFAHADVPFERLVEVLNPVRS- 12586 Query: 371 RDGMDLLVRLGFNMRKSAG-GLALDGVVVRQLGLGAVAAHLPLSLTI----ALD--PDDV 423 + L ++G + + A L G+ V + GA A L +T+ A D P ++ Sbjct: 12587 -TARNPLFQMGLSFQNLAETAFELPGLSVSAVDFGAQLAKTDLHVTVFDRYAEDGTPAEI 12645 Query: 424 SVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGEL 482 EF Y L V + +L+++D +A+ P+ +D+LGA E + +L + Sbjct: 12646 VAEFGYATDLFDESTVRGFVDRFLRVLDTVVADQSVPVGDIDLLGADEAEQILRTWNDTA 12705 Query: 483 VEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAE-----LTYSELHRRANRLARWFIGQGF 537 E+ T + V+D E LTY+EL R NRLAR IGQG Sbjct: 12706 HEVDRTATLVSLLDAAVAAVDPDTVALVADVVEGERVTLTYAELDARVNRLARHLIGQGV 12765 Query: 538 GPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPE- 596 G ED + L + S + ++AM AV KAGAAY+P+DP P ER+ Y++ A P V+ Sbjct: 12766 GTEDRVALAIRRSADLVIAMYAVAKAGAAYVPVDPDQPAERVGYILDTAAPVCVLTTARD 12825 Query: 597 ---LDVAERAAADNSDL------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHH 647 D A D DL P++ ++R+RPL + AYVI+TSGSTG PKGVAV H Sbjct: 12826 GFTTDAAPTVILDELDLSGYAATPIAAAERVRPLAAANTAYVIFTSGSTGVPKGVAVPHG 12885 Query: 648 AIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYV 707 AIA + AE+ + ++ L ++ +FD S+ + + G +LIV D D +Y+ Sbjct: 12886 AIANQLFWKTAEFGLGTDNVVLLKTAATFDLSVWEFWSAAVSGGRLIVATADGHRDPAYL 12945 Query: 708 ADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAEL 767 L+ GVT LR + GEALP A RF AEL Sbjct: 12946 NALMGETGVTTLHVVPSMLDALLTDAGDRMPDTLRRILAIGEALPAATAQRFRRNNTAEL 13005 Query: 768 RNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGG 827 N YGPTEA V T V V IG P N YVLD +L PVP V GELYL G Sbjct: 13006 YNLYGPTEAAVSITSHRVDDDDTVSV-SIGAPEWNSQVYVLDLRLRPVPVGVAGELYLAG 13064 Query: 828 SQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGF 886 +QLARGY RP LTA RF+ADPF G R+YRTGDLV GELE+ GR D QVKIRGF Sbjct: 13065 AQLARGYFARPDLTADRFVADPFGVAGTRMYRTGDLVAWTADGELEYRGRTDFQVKIRGF 13124 Query: 887 RIELGEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVPAAAQVDLEE--IRAHTAAAV 943 RIELGE+E+ + +V V+A + G L AY+VPAA DL+ +++ A + Sbjct: 13125 RIELGEIEAALLRQDSVSAAAVLAHTDPNLGDRLVAYVVPAARDADLDTRALQSALTAEL 13184 Query: 944 PEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGR 1003 P YMVPGAF V+ +P+ +GKLDR ALP P+ YR P T ER + +FA + G Sbjct: 13185 PSYMVPGAFVVLDALPLNANGKLDRNALPEPS-FEQAAYRAPVTPAERIVAEVFADVLGV 13243 Query: 1004 Q-----RVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVER 1058 R+GA+D FF LGG+S+L+ +LVA+ +A GV +VR +FD + A LAA Sbjct: 13244 DGAGDTRIGADDDFFALGGNSILSIQLVARAKAA-GVAFSVRDVFDQRSVAALAAVATLS 13302 Query: 1059 FRNDFEL-DLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEF 1117 D EL +L ++P+ P A L A +YR Sbjct: 13303 GAADTELRELPGGGVGEIPVAPPMAA------------------LLAQDRYRGLAQATVL 13344 Query: 1118 NMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVP-------YQIVHPSRTVQ 1170 MP AL + RH+ALRT E +G P ++ R V+ Sbjct: 13345 AMPQALDW------WTLLDALAVILDRHDALRTRVRETDGGPVFEAPAHIEVEPLVREVR 13398 Query: 1171 LAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPD-THVLLLIVHHIVSDHASL 1229 +A R D P +G + Q L D T LL++ H V D S Sbjct: 13399 VA-RGADLARLRAAEQAAAVDRLDPAAGVMTQFVLFTFEDDRTDELLVVAHRFVVDGPSW 13457 Query: 1230 EIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLP 1289 I+ +L A RL +AP LP W E + EL +W++ +A P Sbjct: 13458 RILGAELTEAVE-RLGVDAPL--ELPETGTTLRRWAHRAAELD-RAAELPFWQE-VAATP 13512 Query: 1290 D------------EISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFML 1337 D + + +R R + G V +VPA R + A + ++ Sbjct: 13513 DPLLGARAFDPAIDTAATVERIRVETPAEIGTAVLDTVPALYRGS---------ARDALV 13563 Query: 1338 YQAALAVVLHKLGGGTDIAL-----GSPVAARVEPATAQLVGLFANVVVLRTDLSG 1388 ALA+V + G GT L G A + A+ VG R +LSG Sbjct: 13564 AALALALVRWR-GEGTAALLRLDADGRAAGAALGATLARTVGWIDTAFPARIELSG 13618 Score = 522 bits (1344), Expect = e-145 Identities = 445/1445 (30%), Positives = 648/1445 (44%), Gaps = 165/1445 (11%) Query: 39 GERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTT 98 GE LS Q+RMWFL D N+ +A RL G +D L A+ DVV RH LRT Sbjct: 5342 GELVPLSYAQQRMWFLNKYDTSSAAYNLPIAIRLTGALDVPALRLALADVVRRHESLRTR 5401 Query: 99 YGVDTEGEPYQVF--SDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPL 156 Y + G P QV ++ +E+ DL + A E + + G FD+ E+PL Sbjct: 5402 YP-EHGGTPVQVVVPAEQIEI-----DLHPVAVAADE--LLETVTEFVGTGFDVAEEVPL 5453 Query: 157 RITVIRTR-ADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPA 204 R + ADE VL++VVHHI D S ++ AY LP+ Sbjct: 5454 RTRLYAVSGADEHVLVVVVHHIAADGFSMGPLTRDVMTAYGARTQGAVPGWAPLPVQYAD 5513 Query: 205 AQFLSVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPL 259 EVL P V YW L A R L Sbjct: 5514 FALWQREVLGAEDDPESLLARQVAYWQRALAGVPDELTLPTDRPRPAVASHRGATLSAEL 5573 Query: 260 PAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GY 318 PA L ++D AR+ AS FMV+ A VL+ R +G+ D V P+ R AA L G Sbjct: 5574 PAELIRALDDVARRHGASLFMVMHGALAVLLARLSGSDDITVGTPIAGRGEAALDELVGM 5633 Query: 319 FGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLV 378 F NTL+LR + FT+ ++ VR T L + + V +R+V PER V Sbjct: 5634 FVNTLVLRTGIDEAEPFTALLDRVRRTDLDAYGNADVPFERLVELLAPERSQARNPLFQV 5693 Query: 379 RLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPD-DVSVEFEYQQQLSSV 436 L F N+ ++ L L G+ V+ L L A L T++ + +++ Y +L Sbjct: 5694 MLAFQNLDRTT--LELPGLSVQALDLEENVARFDLQFTLSENAAAGMTLALTYATELFDA 5751 Query: 437 LVDQMLVHYLQLVDKALA-EPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 +V Q V A+A +P P+ ++D+L E+ ++A++ V P T+ + Sbjct: 5752 ATAAEIVRRWQRVLAAIAADPALPVGAIDVLEPAEQADLVARTGAPAV--PPRTLPELLA 5809 Query: 496 XXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIV 555 V + L+Y+EL R+NRLAR I +G G ED++ + + S + + Sbjct: 5810 EAAARDPQAPAV--VFEGTSLSYAELDERSNRLARLLIAEGIGAEDLVAVGVPRSADSVF 5867 Query: 556 AMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI-------GRPELD---VAERAAA 605 A AV K GAA++P+DP YP ERI +++TD+ + G P+ V E Sbjct: 5868 AAWAVAKTGAAFVPVDPNYPAERIAHMVTDSGSPVGLTVAAVLDGLPDSTRWLVLEELDL 5927 Query: 606 DNSDL-PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTA 664 D D P+++++R+RP RP AYVIYTSGSTG PKGV V+H +A V + + + Sbjct: 5928 DAFDGGPITEAERVRPTRPEQPAYVIYTSGSTGVPKGVVVTHAGLANFRAEQVQRYDIDS 5987 Query: 665 EDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXX 724 R L F+S SFDAS+ ++ + L G L+V P +G +++LI R VT Sbjct: 5988 GTRALHFASPSFDASILELLLALGAGGALVVVPPGVYGG-EELSELIRRERVTHAFITPA 6046 Query: 725 XXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFA------GYFDAELRNHYGPTEAVV 778 LR + GGEA P E+ ++A G A N YGPTE + Sbjct: 6047 ALATFDPTGLDT----LRVLVAGGEACPPELVAKWAVPLGDTGRIRA-FHNGYGPTETTI 6101 Query: 779 CSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRP 838 + + +V IG P R + + +LD +L PVP V GELYL G QLARGY RP Sbjct: 6102 MTN--ISDALMPGELVTIGGPIRGMRSLILDNRLRPVPVGVAGELYLSGIQLARGYHARP 6159 Query: 839 TLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVIT 898 LTA RF+A+P+ PG R+YRTGD+VR GE+E+VGR+D QVK+RGFRIELGE+++ + Sbjct: 6160 GLTADRFVANPYVPGERMYRTGDVVRWTRTGEVEYVGRSDFQVKVRGFRIELGEIDAALA 6219 Query: 899 THPAVRHCLVVAEETEAG-PMLAAYLVPAAA-QVDLEEIRAHTAAAVPEYMVPGAFAVIP 956 +H +V + V + AG +L +Y+V A +D+ + H +P YMVP + VI Sbjct: 6220 SHESVDFAVTVGHDNAAGATVLVSYVVAAPGHSIDVPTLTGHVEQRLPAYMVPSSIMVID 6279 Query: 957 EIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLG 1016 +P+T GKLDR+ALP P +R P T E+ I +FA++ G +RVG +DSFF LG Sbjct: 6280 RVPLTPVGKLDRKALPEPVFATEVVFRAPRTPLEQTIAEVFAEVLGVERVGVDDSFFALG 6339 Query: 1017 GHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMP 1076 G S+++ +LV++ +A GV T R +F+ T AGLAA + Sbjct: 6340 GDSIVSIQLVSRAKAR-GVVFTPRHVFEQKTVAGLAA---------------------VA 6377 Query: 1077 LDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIE--GAREEFNMPLALRFEGPXXXXXX 1134 A P A P + L ++ E G+ FN +AL Sbjct: 6378 ETGDAAAPAVSALAEPPGGGVGPMPLTPVVRFMAERPGSFGRFNQTVALELPAGIDRAGI 6437 Query: 1135 XXXXXXXXXRHEALRTNFDEHEGVPYQI----------------------VHPSRTVQLA 1172 RH+ LR H+G + + R V++A Sbjct: 6438 VSTVGAVIDRHDMLRARL-YHDGTDWVVETAAPGTVDVDALVERVEIPADADDDRLVEIA 6496 Query: 1173 VRAIDQ--DEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLE 1230 A+D D D + + R V+ + P LLVL HH+V D S Sbjct: 6497 SAALDSALDRLDPAAGTVIRFVWLDPATPQRMGRLLVL----------AHHLVVDGVSWR 6546 Query: 1231 IVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPD 1290 I+ D + A+ P+ +A E ELDYWR +AG D Sbjct: 6547 ILVPDFVTAWGQLSAGQQPELVAPATSMRAWAHALATEAERPERVAELDYWR-TVAGATD 6605 Query: 1291 EISVATDRARPRVLGKRGEVVQFSV---PAARRAALTQL--------------------- 1326 + T+R + G + + +V P +A LT + Sbjct: 6606 PL--LTERPMDPAVDVSGAIEKVAVEVSPEVTKALLTTVPALFHGGVNDGLLTALALATA 6663 Query: 1327 ---AERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLR 1383 A R GA +Q +L + L G D+ G+ + ++ VG F + +R Sbjct: 6664 QWRARRTGAA----HQDSLLIRLEGHGREEDVVPGADL--------SRTVGWFTAIFPVR 6711 Query: 1384 TDLSG 1388 DLSG Sbjct: 6712 FDLSG 6716 Score = 157 bits (398), Expect = 9e-36 Identities = 172/664 (25%), Positives = 287/664 (43%), Gaps = 53/664 (7%) Query: 72 LAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAG 131 L+G VD +RLH + ++ R+ LRT + D++G+ QV D VEV WR DL +PE Sbjct: 13806 LSGSVDAERLHASAQAILDRYPNLRTAFVADSDGQAVQVVLDRVEVPWREVDLRDVPEDR 13865 Query: 132 HERQI-ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGE 190 ++ + LAAD+ R FD+ +R T+ RT ADE L + HH+ D S + + Sbjct: 13866 RLDELRKQLAADQADR-FDMATPPLVRYTLYRTGADEWHLSITTHHVLLDGWSMPLLMQD 13924 Query: 191 ---LSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGAN 247 L A + D+ P A + + P A + WAE + A Sbjct: 13925 LLVLYAVHGDVSALPPVASYRTFLEWLAERDPQ-ASLRTWAEAFEGLTEPTELAPQARAT 13983 Query: 248 PCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTE 307 + + V L A ++ + + ++ AA+G+LV R G SD + V+ Sbjct: 13984 EEYQTGKVVVELDAERTRQLTKHCAELGITVNTLVSAAWGILVGRLVGRSDVVFGTTVSG 14043 Query: 308 RSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREA 364 R G +G F NTL +R+ T + ++ H VG+ + R A Sbjct: 14044 RPAELPGVETMVGLFINTLPVRMRIDEHATIGDQLRRMQREQADLLDHHYVGLPDIQRVA 14103 Query: 365 NPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVS 424 P D + + + A ++DG+ V +G+ + + H PL+L + L+ + Sbjct: 14104 GPGSQ-FDTLYVFESYPVDRAAIAEASSIDGMSVTGVGV-SNSTHYPLTLQVLLE-SSLE 14160 Query: 425 VEFEY-QQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHG--- 480 + EY + + V + L+++D L +P + +DIL ER ++L HG Sbjct: 14161 ITLEYLTSRFTEDEVRTLARRLLRVLDALLGDPVAAVGEIDILDESERAALLG-DHGLAG 14219 Query: 481 ---ELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGF 537 E + A T+ K + + E+ Y L RR+++LAR IG+G Sbjct: 14220 HAPEPNRLGARTVAK--VLAEVVEADPEAPALLDGDQEIAYHVLDRRSSQLARVLIGRGV 14277 Query: 538 GPEDIIGLRMANSIEFIVAMLAVLKAGAAYL---PIDPA-YPDERIDYLIT------DAR 587 GP D++ + + S++ +VA+ AV KAGAA L +D Y IT DA Sbjct: 14278 GPGDVVAVALPRSVDSVVAVWAVQKAGAACLFAAGLDAGQLAAAGAGYGITAEPRSGDAV 14337 Query: 588 PQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHH 647 V G ++ AA + P+S +DR+RPL H A+V G+ V ++ Sbjct: 14338 RWVVSGEQQVRDEIAAAPGH---PVSYADRVRPLGAEHPAFVELVDGAP-----VTLNQE 14389 Query: 648 AIAEHVQGFVAEWTMTAEDRWLQFSSVSFD------ASLADIFVTLFLGAQLIVPKPDAF 701 + + + +ED + + S +F A+LA+ T GA ++P Sbjct: 14390 EALD-----LGDRLRRSED--IDYESTTFTTAAAGRAALAEFLATSVAGALSVLPTGSVA 14442 Query: 702 GDIS 705 D++ Sbjct: 14443 DDLA 14446 Score = 65.5 bits (158), Expect = 6e-08 Identities = 87/342 (25%), Positives = 143/342 (41%), Gaps = 26/342 (7%) Query: 1144 RHEALRTNF-DEHEGVPYQIVH-----PSRTVQLAVRAIDQDE-FDDVSTQL---RRHVF 1193 R+ LRT F + +G Q+V P R V L R + +D D++ QL + F Sbjct: 13825 RYPNLRTAFVADSDGQAVQVVLDRVEVPWREVDL--RDVPEDRRLDELRKQLAADQADRF 13882 Query: 1194 TPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDI 1253 + PL++ L G D L + HH++ D S+ ++ DL+V Y +A Sbjct: 13883 DMATPPLVRYTLYRTGADEWHLSITTHHVLLDGWSMPLLMQDLLVLYAVHGDVSA----- 13937 Query: 1254 LPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQF 1313 LP A Y + E + Q L W +A GL + +A +AR + G+VV Sbjct: 13938 LP-PVASYRTFLEWLAERD-PQASLRTWAEAFEGLTEPTELA-PQARATEEYQTGKVV-V 13993 Query: 1314 SVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVE--PATAQ 1371 + A R LT+ G T L AA +++ +L G +D+ G+ V+ R P Sbjct: 13994 ELDAERTRQLTKHCAELGITVNTLVSAAWGILVGRLVGRSDVVFGTTVSGRPAELPGVET 14053 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 +VGLF N + +R + T+ L + D L H + + + P Sbjct: 14054 MVGLFINTLPVRMRIDEHATIGDQLRRMQREQADLLDHHYVGLPDIQRVAGPGSQFDTLY 14113 Query: 1432 LFQNMLNFR---GEDWALVPRDLTGRGETTVVPLPVNFEVAL 1470 +F++ R E ++ +TG G + P+ +V L Sbjct: 14114 VFESYPVDRAAIAEASSIDGMSVTGVGVSNSTHYPLTLQVLL 14155 Score = 56.6 bits (135), Expect = 3e-05 Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 2/89 (2%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E+ + + E+L + + D+++FALGGDSI++I+ ++A A G+ F P VFE T+A Sbjct: 6313 EQTIAEVFAEVLGVERVGVDDSFFALGGDSIVSIQLVSRAKARGVVFTPRHVFEQKTVAG 6372 Query: 1620 LAAAVDAAN-GEPVVEA-DPPPAQEYTPM 1646 LAA + + P V A PP PM Sbjct: 6373 LAAVAETGDAAAPAVSALAEPPGGGVGPM 6401 Score = 55.5 bits (132), Expect = 7e-05 Identities = 33/92 (35%), Positives = 53/92 (57%), Gaps = 4/92 (4%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTIA 1618 + + A+ E+L++ + D+++F LGG+S+IA + +A+ GA LG P +FE T+ Sbjct: 5257 QETVAAVFAEVLDVPRVGVDDDFFELGGNSLIATRVAARIGAALGTTVPVRTLFEASTVE 5316 Query: 1619 ELAAAVDAANGEPVV---EADPPPAQEYTPMS 1647 LAA V++ G P V A P A E P+S Sbjct: 5317 ALAARVESHTGGPAVARLAARPRAAGELVPLS 5348 Score = 49.7 bits (117), Expect = 0.004 Identities = 27/63 (42%), Positives = 43/63 (68%), Gaps = 4/63 (6%) Query: 1572 EITGIDR---DENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIAELAAAVDAA 1627 ++ GIDR D+++FALGG+S++A + +A+ G AL P +FE T+A LAA V++A Sbjct: 4176 DVLGIDRVGLDDDFFALGGNSLVATQLTARLGAALDTQIPLRTLFEASTVAALAAKVESA 4235 Query: 1628 NGE 1630 G+ Sbjct: 4236 TGQ 4238 Score = 45.8 bits (107), Expect = 0.052 Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 16/102 (15%) Query: 1561 RRLTAMLEELL-----EITGIDR---DENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMV 1611 R T +EE++ E+ G+ R D+++F LGG+S+IA + +++ G AL P M+ Sbjct: 2020 RAPTTPIEEIVAQIFGEVLGLPRVGVDDDFFDLGGNSLIATQVASRLGIALDTRVPVRML 2079 Query: 1612 FEHMTIAELAAAVDAANGE----PVVEADPPPAQEYTPMSAS 1649 FE T+A LAA V++ G+ +V D P E P+S S Sbjct: 2080 FEASTVAALAARVESQAGDGARKALVAKDRP---EQVPLSLS 2118 Score = 43.9 bits (102), Expect = 0.20 Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 5/68 (7%) Query: 1560 ERRLTAMLEELLEITG-----IDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEH 1614 ER + + ++L + G I D+++FALGG+SI++I+ A+A A G+ F VF+ Sbjct: 13230 ERIVAEVFADVLGVDGAGDTRIGADDDFFALGGNSILSIQLVARAKAAGVAFSVRDVFDQ 13289 Query: 1615 MTIAELAA 1622 ++A LAA Sbjct: 13290 RSVAALAA 13297 Score = 40.8 bits (94), Expect = 1.7 Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 7/93 (7%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E + + ++L + + D+++FALGG+S++A + +A+ G AL +FE T+ Sbjct: 12149 EEIVAGVFADVLGLERVGADDDFFALGGNSLVATQVTARLGKALDTQLAVRDLFEASTVE 12208 Query: 1619 ELAAAVDAANG----EPVVEADPPPAQEYTPMS 1647 LAA + G P + A P P E P+S Sbjct: 12209 ALAARAERKTGTGRARPALVAGPRP--ERIPLS 12239 Score = 40.4 bits (93), Expect = 2.2 Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 10/86 (11%) Query: 1572 EITGIDR---------DENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIAELA 1621 E+ G+D+ D+++FA GG+S++A + +++ G AL P ++FE T+A LA Sbjct: 11085 EVLGLDQSAGGARIGLDDDFFAWGGNSLLATQVASRLGAALNTRVPVRLLFEAPTVAALA 11144 Query: 1622 AAVDAANGEPVVEADPPPAQEYTPMS 1647 V+ G + P E P+S Sbjct: 11145 VRVEQQAGTGRLALTARPRPERIPLS 11170 >tr|Q0S5D8|Q0S5D8_RHOSR Tax_Id=101510 SubName: Full=Non-ribosomal peptide synthetase; EC=5.1.1.11; EC=5.1.1.12;[Rhodococcus sp.] Length = 6063 Score = 768 bits (1982), Expect = 0.0 Identities = 532/1496 (35%), Positives = 758/1496 (50%), Gaps = 97/1496 (6%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS Q+RMWFL DP+ NI +A RL+G ++ + L TA+ DV+ RH LRT + Sbjct: 3693 RIPLSLAQQRMWFLNQFDPESAAFNIPLAIRLSGDLNIELLQTALVDVIDRHEALRTMFP 3752 Query: 101 VDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITV 160 D++ P QV V +LT PE ++ +L D FD+ E+PLR+ + Sbjct: 3753 -DSDHGPSQVI-----VPTSALELTLTPERVAPEEVHALVFDFVVCGFDVAREVPLRVKL 3806 Query: 161 IRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFLS 209 + E VL +VVHHI D S ++ AY + L + Sbjct: 3807 FQLGDHEFVLAMVVHHISSDGGSAAPMSRDIVVAYAARREGHEPGWSPLEVQYVDYTLWQ 3866 Query: 210 VEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAGL 263 E+L P+ + YW E L P ++ R + L + L Sbjct: 3867 REILGAEDDPTSVISEQLRYWTEVLADLPEMVELP-TDHPRPAVQSPRGAKVGFTLSSNL 3925 Query: 264 FSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNT 322 R+E A++ +++ FMV+ A+ VL+ R +G D + + R A L G FGNT Sbjct: 3926 AERIEYLAQEYNSTFFMVVHASLAVLMARLSGTEDIPIGTQIAGRGDPALDDLIGMFGNT 3985 Query: 323 LLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERM-GRDGMDLLVRLG 381 L+LR +F + +VRE LA F + V ++R+V NP R + ++ + Sbjct: 3986 LVLRSRVDPAMSFADILADVREVDLAAFGNPDVPLERLVEVLNPRRSTAHSALFQVLLVV 4045 Query: 382 FNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD----------VSVEFEYQQ 431 N +S + L G+ + L V A L L L D + + Q Sbjct: 4046 HNFVRSR--VTLPGLEIAPLETDIVGAKLDLELHFTATSDSEGHRTGIEGSIVYALDLFQ 4103 Query: 432 QLSSVLVDQMLVHYLQLVDKALAEP--ERPLSSLDILGAGERDSVLAQSHGELVEMPATT 489 Q + LV L+ V + + P E L S+D A +R + A V + T Sbjct: 4104 QSTVARFATQLVTILEAVTRDVTIPVGEIELRSVDERAAMDRWNATA------VVVEGGT 4157 Query: 490 MVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMAN 549 +V+ V +E LTY+E RAN+LAR+ I + GPE ++GL M+ Sbjct: 4158 LVQLFDEQVRRTPDAVAV--VFEEQSLTYAEFDSRANQLARYLISREVGPESLVGLGMSR 4215 Query: 550 SIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI----GRPELDVAERAA- 604 S+ +V++ VLKAGA YLP+DP +P R +Y++ A+P V+ R +L A A Sbjct: 4216 SLAMMVSIYGVLKAGAGYLPLDPEHPAHRTEYVMATAKPVVVLTTSRDRDDLPAAVDAVE 4275 Query: 605 ADNSDLPL------SDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVA 658 D DL + +D+ RL PLRP +LAY I+TSGSTGRPKGVAVSH ++ + + Sbjct: 4276 VDVLDLSVFDAEAVTDASRLAPLRPENLAYAIFTSGSTGRPKGVAVSHRSVVNQIAWMRS 4335 Query: 659 EWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTV 718 + + D L + ++FDAS+ ++F L +GA+L++ P D Y+ + R VT+ Sbjct: 4336 RYALGDRDTVLHKTPITFDASVWELFYPLQVGARLVIAAPGGHRDPEYLMRMSDRWHVTI 4395 Query: 719 XXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVV 778 R LR+V VGGEALP E+A RFA +A L N YGPTE V Sbjct: 4396 LEFVPSMLALFLAESSLALPRSLRYVSVGGEALPSELAARFAARTEAVLDNTYGPTEVTV 4455 Query: 779 CST-HMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGR 837 ST H + G+ G +PIG P RN +VLD +LH VP V GELYL G QLARGY R Sbjct: 4456 TSTVHRCLAGASGP--IPIGRPIRNTRTFVLDRRLHRVPVGVPGELYLAGIQLARGYHAR 4513 Query: 838 PTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESV 896 LTA+RF+A PF + G RLYRTGDLVR N G+LE++GR D QVK+RG RIELGE+E+ Sbjct: 4514 GALTAERFVAHPFADSGERLYRTGDLVRWNSNGDLEYLGRTDFQVKLRGLRIELGEIETA 4573 Query: 897 ITTHPAVRHCLVVAEETEAGPMLAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVI 955 +T +V +VV + E G L Y++P + VD+E R + ++P YMVP V+ Sbjct: 4574 LTADESVDQAVVVVRDGEFGQQLVGYVLPTRGRTVDVEATREVVSTSLPNYMVPDVLVVL 4633 Query: 956 PEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGL 1015 +P+ SGKLDRRALPAP+ R +R P T E + IFA++ G +RVG +D FF L Sbjct: 4634 DALPLNPSGKLDRRALPAPS-FVVRGFRAPTTPVEEVVAGIFAEVLGLERVGLDDDFFAL 4692 Query: 1016 GGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDM 1075 GG+SL+A +LV+++ A + VR IF+A T A LA R + Sbjct: 4693 GGNSLVATQLVSRLGAALDTRVPVRVIFEASTVAALAVRAEQHAGEG------------- 4739 Query: 1076 PLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXX 1135 RP + RP R+PLS +Q WF + + +N+PL +R G Sbjct: 4740 ------GRPALTRRVRPARIPLSLAQQRMWFLNQFDPESAAYNIPLVVRLSGELDVAAIQ 4793 Query: 1136 XXXXXXXXRHEALRTNF-DEHEGVPYQIVHPSRTVQ--LAVRAIDQDEFDDVSTQLRRHV 1192 RHEALRT F D +G +IVH S + D++E L Sbjct: 4794 ASVLDVFARHEALRTVFPDSDQGPAQRIVHASGVSMDLTPIPVADEEELRMRVAALLTAG 4853 Query: 1193 FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWD 1252 F ++ L + H+L ++VHHI +D S + D++VAY +R + P W Sbjct: 4854 FEVTVSVPVRGALYRVSKSEHILAVVVHHICADGFSTGPMGRDVLVAYASRHAGHEPSWT 4913 Query: 1253 ILPIQFADYAVWQRNTFES-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKR 1307 LP+Q+ADYA+WQR S + ++ YW DAL+GLPD +++ TDR RP V Sbjct: 4914 PLPVQYADYALWQREVLGSEDDPGSLMSQQIAYWLDALSGLPDALALPTDRPRPPVRSGL 4973 Query: 1308 GEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEP 1367 G V F+VPAA A L LA GAT FM+ AALAV+L +L G TDIA+GSP+A R + Sbjct: 4974 GSSVDFTVPAATVARLVSLAREAGATPFMVVHAALAVLLARLSGATDIAIGSPIAGRGDA 5033 Query: 1368 ATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRAL 1427 A LVG+F N +VLR D + +L RD L+A + ++P ERLVE LNP R+ Sbjct: 5034 ALDDLVGMFVNTLVLRAQYEPDESFAELLGRMRDVDLEAFSRADVPFERLVEKLNPIRSQ 5093 Query: 1428 SRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSG 1483 S +PLFQ ML F+ + V +L G TV P+ V+ + L++ + + G Sbjct: 5094 SFSPLFQVMLAFQNFNRPTV--ELPG---LTVSPVEVDRQAVQFDLSMTVGESADG 5144 Score = 724 bits (1869), Expect = 0.0 Identities = 522/1513 (34%), Positives = 743/1513 (49%), Gaps = 104/1513 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNIC-VAYRLAGLVDEDRLHTAVNDVVARHAILRTT 98 E + LS Q + F T+ D + + + L G VD RL A V+A HA LR Sbjct: 1584 EIWSLSPLQSGLLFHSTLAADSLDIYTAQLRIDLEGAVDSARLRRAAAGVLAHHANLRAA 1643 Query: 99 YGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRI 158 + D G P Q+ D V+V WR DLT A E ++E L D+ FDLT LR+ Sbjct: 1644 FEYDDHGLPAQLVVDTVDVPWREVDLTGYGTAAGE-ELERLLDDDRVARFDLTRPPLLRL 1702 Query: 159 TVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND-----LPINDPAAQFLSVEVL 213 +IRT + VL L HHI D S + EL Y LP P + +L Sbjct: 1703 LLIRTAPGQYVLALTNHHIILDGWSMPLLVRELLVRYAADDAPALPEPRPYSTYLEWVAT 1762 Query: 214 QNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARK 273 ++ A A W L + + LPA L ++ + Sbjct: 1763 RDRDASFRA----WERALEGLEEPTLLAPHASSEQFGVPAEVDIALPAALIDALDTVVAR 1818 Query: 274 CSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA---LGYFGNTLLLRITTR 330 + V+ AA+G+L+ R D + V+ R +G LG F NT+ +R+ Sbjct: 1819 HGVTMNTVVQAAWGMLLSRLLSRRDVVFGATVSGRPPQLSGVESMLGLFINTVPVRMRID 1878 Query: 331 SQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM--DLLVRLGFNMRKSA 388 +T + ++ ++ H +G+ + RMG + L V + + KS Sbjct: 1879 PDETCAQLLTRLQGEQVSLLDHHYLGLGDI-----QARMGLGNLFDTLSVFESYPVDKSG 1933 Query: 389 GGLALDGVVVRQLGLGAV-AAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYL 446 D +R L A A H P++L L+P + + YQ + V + + Sbjct: 1934 FDEHTDIAGMRVTALDARDATHYPITLLSILEPR-LRLSLRYQHGIFDRATVTTLAARVI 1992 Query: 447 QLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXX 506 +++ + P+ +D+ ER+ V+ + ++P T+ + Sbjct: 1993 GILETIARDAGTPVGDVDLFVPTERELVVDTWNATEHQVPRLTLAELFDAQVAHTPNAPA 2052 Query: 507 XXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAA 566 V + +TY+E RAN+LAR+ I G GPE ++G+ + S++ +V + AV+KAG A Sbjct: 2053 V--VFEGTGVTYAEFDARANQLARFLISGGVGPESLVGVAVRRSVDLLVGIYAVIKAGGA 2110 Query: 567 YLPIDPAYPDERIDYLITDARPQTVIGR-----------PELDVAERAAADNSDLPLSDS 615 Y+PIDP P ERI Y++ A P V+ P +D+ + SD P+ D Sbjct: 2111 YVPIDPDQPAERIAYVVATAGPIVVLTMTADRVALPAEVPAVDLDTLDVSALSDDPVRDR 2170 Query: 616 DRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 DRL PL + AYVI+TSGSTGRPKGVAV H I + + ++ +D L + V+ Sbjct: 2171 DRLGPLHTRNPAYVIFTSGSTGRPKGVAVPHEGIVNRLLWMQHRYPLSDDDVVLHKTPVT 2230 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FD S+ ++F L GA+L++ +PD D +Y+ +I VT Sbjct: 2231 FDVSVWELFWPLQTGARLVIAEPDGHRDPAYLERVIRAESVTTVHFVPSMLAVFLAGAHV 2290 Query: 736 XQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVP 795 LR V GEALP A +AEL N YGPTEA V T+ TG VP Sbjct: 2291 DGCSSLRRVFTSGEALPPMTAAALHRASEAELHNLYGPTEASVDVTYYE-TGPDET-TVP 2348 Query: 796 IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF----- 850 IG P N YVLD +L PVP V GELYLGG QLARGY GR LTA RF+A+PF Sbjct: 2349 IGAPIWNTQTYVLDGRLQPVPVGVAGELYLGGVQLARGYQGRSDLTADRFVANPFVAAGN 2408 Query: 851 -NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCL-V 908 G RLYRTGDLVR G+LE++GR D QVK+RG RIELG++E+ + H V + + Sbjct: 2409 VRVGSRLYRTGDLVRWLPTGQLEYLGRTDFQVKLRGQRIELGDIEAALLRHGDVAQAVAL 2468 Query: 909 VAEETEAGPMLAAYLVPAAAQVDLEE-IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLD 967 V + G LA Y+VPA + E + AA +P YMVP A V+ ++P+T +GKLD Sbjct: 2469 VRNDGSTGDYLAGYVVPAPGRSPAERAVLDFAAATLPRYMVPSALVVLAQLPLTANGKLD 2528 Query: 968 RRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVA 1027 R+ALP P ++ ++ P T TE + I A + G R+G D+FF LGG+SL+A R+VA Sbjct: 2529 RKALPVPEFASSAQFVPPGTPTEYVLAEILADVLGASRIGMSDNFFDLGGNSLIATRVVA 2588 Query: 1028 QIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFV 1087 +I AE G L VR++F+APT G+ A +V+R A P RP V Sbjct: 2589 RINAELGTGLNVRSLFEAPT-VGVLATVVDRTH-----------AGAGP------RPTLV 2630 Query: 1088 KSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEA 1147 RP RLPLS +Q WF + + +N+ ALR G RHE+ Sbjct: 2631 SGPRPDRLPLSLAQTRMWFFNQFDPTSSAYNVAAALRLSGSLDVDALRRAAADILDRHES 2690 Query: 1148 LRTNFDEHEGVPYQIVHPS------------------RTVQLAVRAIDQDEFDDVSTQLR 1189 LRT F + PYQ+V P+ + +RA FD V+TQ+ Sbjct: 2691 LRTMFPQSPDGPYQLVLPADHAATGDLIDVVPDVVPAAALDARIRAAVTRGFD-VTTQI- 2748 Query: 1190 RHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAP 1249 P+ + PD HVL+++VHHI D S++++ DL+ AY R +AP Sbjct: 2749 ---------PIALTLVRCEAPDEHVLVMVVHHISIDGWSIQVLARDLVHAYSTRTAGDAP 2799 Query: 1250 QWDILPIQFADYAVWQRNTFESNWGQT-----ELDYWRDALAGLPDEISVATDRARPRVL 1304 W LP+Q+ADYA+WQR+ S T EL++W DALAGLPD +++ DR RP V Sbjct: 2800 SWTPLPVQYADYALWQRDVLGSEDDPTSLMSQELEHWADALAGLPDVLALPLDRPRPGVR 2859 Query: 1305 GKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAAR 1364 G V F+VPAA L LA +GAT FM+ AALAV+L KL G TDIA+GSPVA R Sbjct: 2860 SGAGASVDFAVPAATVVCLVSLAREHGATPFMVVHAALAVLLAKLSGSTDIAIGSPVAGR 2919 Query: 1365 VEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPP 1424 + A LVG+F N +VLR D + ++ RD+ L+A ++P ERLVE LNP Sbjct: 2920 GDAALDDLVGMFVNTLVLRADCEPSRSFAELVGRVRDSDLEAFGRPDVPFERLVEKLNPV 2979 Query: 1425 RALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGE 1484 R+ S +PLFQ ML F +++A +L G TV P+ V +E A L++ +S G Sbjct: 2980 RSQSFSPLFQVMLAF--QNFAPSRVELPG---LTVSPVAVEWEAAQFDLSMTLSEAGGGG 3034 Query: 1485 LDVQVIANADLYE 1497 ++ D+++ Sbjct: 3035 YGGRLSYTTDIFD 3047 Score = 678 bits (1749), Expect = 0.0 Identities = 474/1453 (32%), Positives = 707/1453 (48%), Gaps = 100/1453 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS Q RMWF DP N+ A RL+G +D D L A D++ RH LRT + Sbjct: 2636 DRLPLSLAQTRMWFFNQFDPTSSAYNVAAALRLSGSLDVDALRRAAADILDRHESLRTMF 2695 Query: 100 GVDTEGEPYQVF--SDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLR 157 +G PYQ+ +D G + + +P+ +++ R FD+T ++P+ Sbjct: 2696 PQSPDG-PYQLVLPADHAATG---DLIDVVPDVVPAAALDARIRAAVTRGFDVTTQIPIA 2751 Query: 158 ITVIRTRA-DELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAA------QFLSV 210 +T++R A DE VL++VVHHI D S +V +L AY+ D + Q+ Sbjct: 2752 LTLVRCEAPDEHVLVMVVHHISIDGWSIQVLARDLVHAYSTRTAGDAPSWTPLPVQYADY 2811 Query: 211 EVLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP---- 258 + Q S D + +WA+ L A P R + VR Sbjct: 2812 ALWQRDVLGSEDDPTSLMSQELEHWADALAGLPDVL-------ALPLDRPRPGVRSGAGA 2864 Query: 259 -----LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA 313 +PA + AR+ A+PFMV+ AA VL+ + +G++D + PV R AA Sbjct: 2865 SVDFAVPAATVVCLVSLAREHGATPFMVVHAALAVLLAKLSGSTDIAIGSPVAGRGDAAL 2924 Query: 314 GAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRD 372 L G F NTL+LR +F V VR++ L F V +R+V + NP R Sbjct: 2925 DDLVGMFVNTLVLRADCEPSRSFAELVGRVRDSDLEAFGRPDVPFERLVEKLNPVRSQSF 2984 Query: 373 GMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIA-LDPDDVSVEFEYQQ 431 V L F + + L G+ V + + AA LS+T++ Y Sbjct: 2985 SPLFQVMLAFQ-NFAPSRVELPGLTVSPVAVEWEAAQFDLSMTLSEAGGGGYGGRLSYTT 3043 Query: 432 QL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTM 490 + + V + +L++++ + P P+ +D+LG ER VLA + + +PA T+ Sbjct: 3044 DIFDASTVRGIAEGFLRVLEAVVENPSVPVGDIDVLGPAERQRVLAGAAPVPLPVPARTL 3103 Query: 491 VKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANS 550 + +++Y +L R+NRLAR I +G GPE + L A S Sbjct: 3104 PEILAAGVASNPLGVAL--TCGGVQMSYPDLDSRSNRLARLLISRGVGPETFVALSFARS 3161 Query: 551 IEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITD---------ARPQTVIGR-----PE 596 IE +V++ AV+K G ++P+DP P ERI++++ D A ++ G+ P Sbjct: 3162 IESVVSVWAVVKTGGGFVPVDPKLPVERIEHMLVDSGAVIGLTSAETTSLPGKVAWLVPT 3221 Query: 597 LDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 + S ++D++R P+ + AY+IYTSGSTG PKGV V+H +A Sbjct: 3222 AGEVQELCDGFSSAEITDAERRAPVTWTNAAYMIYTSGSTGVPKGVVVAHAGLASFCADA 3281 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGV 716 E +T R L+ SS SFDAS+ ++ GA L+V P+ G S +A+L+ V Sbjct: 3282 RLELNLTGNSRVLRLSSSSFDASVFEMIAGFSAGATLVVAPPEIIGG-SELAELLRVERV 3340 Query: 717 TVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEA 776 T +L+ V VGG+ P E+ +FA + N YGPTE Sbjct: 3341 THIITAPAALGIVDPGGLD----ELQAVVVGGDVCPPELVAKFAPF--CRFYNSYGPTET 3394 Query: 777 --VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGY 834 ++ T +V + IG P A VLD +LHP P VIGELYL G LARGY Sbjct: 3395 TIIISMTEALVPEER----ITIGTPIEGAGAVVLDARLHPSPVGVIGELYLSGRGLARGY 3450 Query: 835 LGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEV 893 R LTA RF+A+PF G R+YRTGDLVR G L+FVGR D QV++RG RIELGE+ Sbjct: 3451 HARGALTAARFVANPFGGSGERMYRTGDLVRWTRDGRLDFVGRIDSQVQLRGLRIELGEI 3510 Query: 894 ESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVP-AAAQVDLEEIRAHTAAAVPEYMVPGA 951 E+ ++ V +VV + G L Y+V + A +D E +R +P YMVP Sbjct: 3511 EAALSRCEGVAQTVVVLRHDPHTGEQLVGYVVADSKAALDPEALRIRVGETLPNYMVPSR 3570 Query: 952 FAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDS 1011 V+ +P+ SGKLDRRALPAP+ R +R P T E + IFA++ G +RVG +D Sbjct: 3571 VMVVDALPLNPSGKLDRRALPAPS-FVVREFRAPTTPVEEVVAGIFAEVLGLERVGLDDD 3629 Query: 1012 FFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLA 1071 FF LGG+SL+A ++V+++ A + VR IF+A T A LA R + Sbjct: 3630 FFALGGNSLVATQVVSRLGAALDTRVPVRVIFEASTVAALAVRAEQHAGEG--------- 3680 Query: 1072 ADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXX 1131 RP + RP R+PLS +Q WF + + FN+PLA+R G Sbjct: 3681 ----------GRPALTRRVRPARIPLSLAQQRMWFLNQFDPESAAFNIPLAIRLSGDLNI 3730 Query: 1132 XXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAV--RAIDQDEFDDVSTQLR 1189 RHEALRT F + + P Q++ P+ ++L + + +E + Sbjct: 3731 ELLQTALVDVIDRHEALRTMFPDSDHGPSQVIVPTSALELTLTPERVAPEEVHALVFDFV 3790 Query: 1190 RHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAP 1249 F L+ L LG VL ++VHHI SD S + D++VAY AR + + P Sbjct: 3791 VCGFDVAREVPLRVKLFQLGDHEFVLAMVVHHISSDGGSAAPMSRDIVVAYAARREGHEP 3850 Query: 1250 QWDILPIQFADYAVWQRNTFESNWGQT-----ELDYWRDALAGLPDEISVATDRARPRVL 1304 W L +Q+ DY +WQR + T +L YW + LA LP+ + + TD RP V Sbjct: 3851 GWSPLEVQYVDYTLWQREILGAEDDPTSVISEQLRYWTEVLADLPEMVELPTDHPRPAVQ 3910 Query: 1305 GKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAAR 1364 RG V F++ + + LA+ +T FM+ A+LAV++ +L G DI +G+ +A R Sbjct: 3911 SPRGAKVGFTLSSNLAERIEYLAQEYNSTFFMVVHASLAVLMARLSGTEDIPIGTQIAGR 3970 Query: 1365 VEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPP 1424 +PA L+G+F N +VLR+ + + IL R+ L A + ++P+ERLVE LNP Sbjct: 3971 GDPALDDLIGMFGNTLVLRSRVDPAMSFADILADVREVDLAAFGNPDVPLERLVEVLNPR 4030 Query: 1425 RALSRNPLFQNML 1437 R+ + + LFQ +L Sbjct: 4031 RSTAHSALFQVLL 4043 Score = 526 bits (1355), Expect = e-146 Identities = 358/1056 (33%), Positives = 524/1056 (49%), Gaps = 59/1056 (5%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS Q+RMWFL DP+ NI + RL+G +D + +V DV ARH LRT + Sbjct: 4752 RIPLSLAQQRMWFLNQFDPESAAYNIPLVVRLSGELDVAAIQASVLDVFARHEALRTVFP 4811 Query: 101 VDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITV 160 +G ++ V DLT +P A E ++ A F++T +P+R + Sbjct: 4812 DSDQGPAQRI----VHASGVSMDLTPIPVADEE-ELRMRVAALLTAGFEVTVSVPVRGAL 4866 Query: 161 IRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFLS 209 R E +L +VVHHIC D S ++ AY LP+ Sbjct: 4867 YRVSKSEHILAVVVHHICADGFSTGPMGRDVLVAYASRHAGHEPSWTPLPVQYADYALWQ 4926 Query: 210 VEVLQNSAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP-------- 258 EVL + P + YW + L A P R + VR Sbjct: 4927 REVLGSEDDPGSLMSQQIAYWLDALSGLPDAL-------ALPTDRPRPPVRSGLGSSVDF 4979 Query: 259 -LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL- 316 +PA +R+ AR+ A+PFMV+ AA VL+ R +GA+D + P+ R AA L Sbjct: 4980 TVPAATVARLVSLAREAGATPFMVVHAALAVLLARLSGATDIAIGSPIAGRGDAALDDLV 5039 Query: 317 GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDL 376 G F NTL+LR ++F + +R+ L F+ V +R+V + NP R Sbjct: 5040 GMFVNTLVLRAQYEPDESFAELLGRMRDVDLEAFSRADVPFERLVEKLNPIRSQSFSPLF 5099 Query: 377 LVRLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSV---EFEYQQQ 432 V L F N + + L G+ V + + A LS+T+ D Y Sbjct: 5100 QVMLAFQNFNRPT--VELPGLTVSPVEVDRQAVQFDLSMTVGESADGGGGFVGRLSYATD 5157 Query: 433 L-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMV 491 + V ++ ++++++ + +P P+ + I+ ER +L + + ++P ++ Sbjct: 5158 VFDGATVREIARRFVRILEVVVDDPMIPVGDVSIVEENERRQMLREWNITGHDVPDGLLL 5217 Query: 492 KXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSI 551 V D L+Y+E R NRLAR I +G GPE ++ L + S+ Sbjct: 5218 DGFDAQVARTPDAVAI--VYDNESLSYAEFSARVNRLARRLIDEGVGPESLVALGIRRSL 5275 Query: 552 EFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIG--RPELDVAERAAA--DN 607 E + + AVL+ GAA++P+DP P R DY++ P V+ R D + D Sbjct: 5276 ELVTGIYAVLRTGAAFVPLDPDQPPARNDYILETTGPVCVLSTARDGFDTSRNRVLNIDA 5335 Query: 608 SDL------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWT 661 DL P+ +S+ + RP +LAYVI+TSGSTGRPKGV+VSH AI + AE+ Sbjct: 5336 PDLSVYSSEPVGESEVVTSARPENLAYVIFTSGSTGRPKGVSVSHRAIVNQMAWLAAEYE 5395 Query: 662 MTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXX 721 + D +Q + V+FD S+ ++ V L +GA++IV +PD D Y+ L+ GVTV Sbjct: 5396 LGDSDVVVQKTPVTFDVSMWELLVPLAVGARMIVARPDGHRDPDYLLSLMQDSGVTVAAF 5455 Query: 722 XXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCST 781 LR V GGE LP E++ R A A L N YGPTE V +T Sbjct: 5456 VPSMLATLLADPEAFLPDSLRCVFAGGEELPVELSGRCASRSKARLDNKYGPTEYAVTAT 5515 Query: 782 HMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLT 841 G VPIG P N A VLD +LHPVP V GELYL G QL+RGY R LT Sbjct: 5516 SHRCDGLE-RESVPIGEPVWNTTALVLDRRLHPVPIGVEGELYLAGVQLSRGYHRRQGLT 5574 Query: 842 AQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 A+RF+ADPF G RLYRTGD+V+ N G+L ++GR D QVK+RG RIELGE+E+ + Sbjct: 5575 AERFVADPFGAAGTRLYRTGDVVKWNPRGQLMYLGRLDSQVKVRGLRIELGEIETALVAQ 5634 Query: 901 PAVRHCLVVAEETEAGPMLAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIP 959 + +V+ + + G L Y+VP + VD+E +RA ++P+YMVP V+ ++P Sbjct: 5635 QTIAQAVVIVHDGDFGQQLVGYVVPEGGRLVDVESVRATAGRSLPQYMVPDVLMVLDQLP 5694 Query: 960 MTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHS 1019 +T SGK DR ALPAP R +R P T ER + S F + G ++VG +D FF LGG+S Sbjct: 5695 LTASGKFDRNALPAP-EFTKREFRGPTTRVERIVASAFTDILGVEQVGLDDDFFALGGNS 5753 Query: 1020 LLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 L+A R+VA+++ + + ++ +F P LAAR+ Sbjct: 5754 LVAPRVVARLKQDLSAAVPLQWLFTDPAVEALAARI 5789 Score = 375 bits (962), Expect = e-101 Identities = 403/1428 (28%), Positives = 596/1428 (41%), Gaps = 135/1428 (9%) Query: 36 ICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED-RLHTAVNDVVARHAI 94 + P E + LS QR MWF Q + DV + + Y G+ D D L + R Sbjct: 29 VWPSEMFPLSAAQRGMWFAQHL-LGDVPI-VIAQYVEVGIADLDIGLLARIGPAALRELG 86 Query: 95 LRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNEL 154 V+ +GEP Q D +G+ L + + E P DL ++ Sbjct: 87 TGLLRIVEWDGEPLQTV--DESLGFEMTHLDFRSDPDPRAAALAWMRAECSNPIDLLHDR 144 Query: 155 PLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSV---E 211 +R ++R D +HHI D F + Y A+F + E Sbjct: 145 LIRSAMLRVADDCYFWYSRIHHIALDGFGAMTFMNRAAELYTAAVEGRAPAEFTASGLRE 204 Query: 212 VLQNSAAPSVA-----DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSR 266 V++ A + D YWAE G A ++ PLPA + Sbjct: 205 VVEEEARYRTSSRFETDRKYWAERSHNLPPTISLAG-RAAEIGAQSLVSSAPLPAATTAA 263 Query: 267 VEDFA-RKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALG-YFGNTLL 324 ++ R+ A+ +AA + R TG D ++S+PV+ R+ A G N L Sbjct: 264 LQSLTDREPGATFATAAVAAVAAFLARLTGQDDVVLSLPVSARTTARLRRSGGMIANVLP 323 Query: 325 LRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANP--ERMGRDGMDLLVRL-- 380 +R++ + T + + HQ + + R+A R G G + + + Sbjct: 324 IRLSVGDETTPVDLMRRTQRELTGALRHQRYRHEDIRRDAGVLGGRRGFFGPSINIMMFH 383 Query: 381 -GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVD 439 + S G L + L G V L +++ + D V+FE L + Sbjct: 384 DEIRLGPSIGRLHV-------LTTGPVE-DLAVNIYPGVAGDVAQVDFEANPNLYTE--Q 433 Query: 440 QMLVHYLQLVDK----ALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 ++ H+++ ++ A A +R +++LD+L A ER L G E P + Sbjct: 434 ELRGHHVRFLEFFAAFASAATDR-IAALDVLHADERAG-LVPCRGPQAE-PERLLPDLLA 490 Query: 496 XXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIV 555 E+TY EL +R+N+LAR I G GPE + L + S E +V Sbjct: 491 DGVAAAPGAVAIRAAG--REVTYRELDQRSNQLARLLIESGAGPETFVALSLPRSAESLV 548 Query: 556 AMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL--------------DVAE 601 A AV K GAA++P+DP P ER+ ++++D+ + EL D Sbjct: 549 AFWAVAKTGAAFVPVDPKLPPERVAHMLSDSGALVGLTLHELRATLPDGIHWLVVDDDEV 608 Query: 602 RAAADNSD-LPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEW 660 RA D + D+DR PL H AY+IYTSGSTG PKGV V+H ++ G E Sbjct: 609 RARCDRQRRAAIGDADRRAPLSVHHPAYMIYTSGSTGLPKGVVVTHTGLSNFAAGARPEL 668 Query: 661 TMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXX 720 + E R L+FSS SFDAS+ ++ GA ++V P+ G S + DL+S + VT Sbjct: 669 GVHDESRMLRFSSASFDASVFEMIQAFSAGATMVVAPPEVHGG-SDLVDLLSEQQVT--- 724 Query: 721 XXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS 780 L V VGG+ ++ +RF N YGPTE Sbjct: 725 -HIITAPTVMNTVDPRGLEHLEAVVVGGDVCTPDLVERFGQV--CRFTNSYGPTE----- 776 Query: 781 THMVVTGSH---GARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGR 837 T +++T + IG P + VLD +L VP V+GELYL G +ARGY R Sbjct: 777 TTIIITAGEPLMPGEPITIGRPIQGTSVVVLDRKLRAVPAGVVGELYLAGPGIARGYHHR 836 Query: 838 PTLTAQRFIADPF-NPGMRLYRTGDLVR--RNHCG------ELEFVGRADEQVKIRGFRI 888 LTA RF+A+PF PG RLYRTGD VR R+ G LEF+GR+D QVKIRGFRI Sbjct: 837 HGLTANRFVANPFGEPGSRLYRTGDEVRWVRSSQGTEAGHYTLEFIGRSDTQVKIRGFRI 896 Query: 889 ELGEVESVITTHPAVRHCLVVAEETEAG-PMLAAYL-VPAAAQVDLEEIRAHTAAAVPEY 946 ELGE++S + V V T G L +Y+ + + D I A VP + Sbjct: 897 ELGEIDSALLAQDGVNFAATVVHRTAGGTTALVSYVRLDTGREFDPVAIVEGVAEIVPSH 956 Query: 947 MVPGAFAVIPEIPMTVSGKLDRRALPAPTPIAT-RRYREPETATERWICSIFAQLFGRQR 1005 M+P A + +P+T +GKLDR ALP P +T +R T E + + A+ G R Sbjct: 957 MIPSAVMRLEHVPVTAAGKLDRSALPQPHFGSTEHEFRAASTPAEEQLSGLVAEALGLDR 1016 Query: 1006 VGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFEL 1065 V +DS F LGG S++A ++ A+ RA FG+ + R +F+ T AG+AA V + + Sbjct: 1017 VSVDDSLFALGGDSIVAMQIAARARA-FGLSFSARAVFEHKTIAGIAAVAVP-VEAESAV 1074 Query: 1066 DLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRF 1125 L+ L + R P+ +S L G +F L L Sbjct: 1075 VLEELEGGGV--------------GRIPPTPIMYSMLE-------RGPFADFFQALLLTL 1113 Query: 1126 EGPXXXXXXXXXXXXXXXRHEALRTNF--DEHEGVPYQIV---------HPSRTVQLAVR 1174 H+ALR+ F D+ ++ SR V A Sbjct: 1114 PSDVDPDRLSATLAAVLDHHDALRSKFVPDDDGTWAFETTAAGSVPAGDRISRIVTAAAP 1173 Query: 1175 AIDQDEFDDVSTQLRRHV--FTPESGPLLQANLLV--LGPDTHVLLLIVHHIVSDHASLE 1230 + D VS + PE+G +LQ V LL+I HH+V D S Sbjct: 1174 G-SRTFTDVVSAECAAAAARLDPENGIMLQLVWCVSESAGAPGRLLVIAHHLVVDGVSWR 1232 Query: 1231 IVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPD 1290 ++ DL A+ P + F +A ++ + EL YWR+ L+G PD Sbjct: 1233 VLLPDLATAWLQLGAGQTPTLAPVGTSFRRWAYGLQDAADRGVHTDELPYWREVLSG-PD 1291 Query: 1291 EISVATDRARPRVLGKR-GEVVQFSV-PAARRAALTQLAE--RNGATEFMLYQAALAVVL 1346 + T P + R E V V PA A L +L + G + +L A+AVV Sbjct: 1292 P-QIGTRPVAPAIDTMRTTERVHIDVSPAVTDAVLARLPDVFGCGVNDGLLSALAMAVVQ 1350 Query: 1347 HKLGGGTD---IALGSPVAARVEPAT-----AQLVGLFANVVVLRTDL 1386 + G D + L R E A A+ VG F + +R +L Sbjct: 1351 WRHSHGIDERSVLLTLEGHGREEEAVAGADLARTVGWFTSAFPVRLEL 1398 Score = 66.6 bits (161), Expect = 3e-08 Identities = 56/212 (26%), Positives = 93/212 (43%), Gaps = 5/212 (2%) Query: 1200 LLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFA 1259 L+++ +L + D + +HHI D + Y A ++ AP + Sbjct: 145 LIRSAMLRVADDCYFWYSRIHHIALDGFGAMTFMNRAAELYTAAVEGRAPA-EFTASGLR 203 Query: 1260 DYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 + + S+ +T+ YW + LP IS+A R +G + V +PAA Sbjct: 204 EVVEEEARYRTSSRFETDRKYWAERSHNLPPTISLA---GRAAEIGAQSLVSSAPLPAAT 260 Query: 1320 RAALTQLAERN-GATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFAN 1378 AAL L +R GAT AA+A L +L G D+ L PV+AR + G+ AN Sbjct: 261 TAALQSLTDREPGATFATAAVAAVAAFLARLTGQDDVVLSLPVSARTTARLRRSGGMIAN 320 Query: 1379 VVVLRTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 V+ +R + + T ++ ++ + AL HQ Sbjct: 321 VLPIRLSVGDETTPVDLMRRTQRELTGALRHQ 352 Score = 59.3 bits (142), Expect = 5e-06 Identities = 31/74 (41%), Positives = 45/74 (60%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E +L+ ++ E L + + D++ FALGGDSI+A++ +A+A A GL F VFEH TIA Sbjct: 1001 EEQLSGLVAEALGLDRVSVDDSLFALGGDSIVAMQIAARARAFGLSFSARAVFEHKTIAG 1060 Query: 1620 LAAAVDAANGEPVV 1633 +AA E V Sbjct: 1061 IAAVAVPVEAESAV 1074 Score = 42.4 bits (98), Expect = 0.57 Identities = 23/72 (31%), Positives = 41/72 (56%), Gaps = 1/72 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E + + E+L + + D+++FALGG+S++A + ++ G AL P ++FE T+A Sbjct: 4667 EEVVAGIFAEVLGLERVGLDDDFFALGGNSLVATQLVSRLGAALDTRVPVRVIFEASTVA 4726 Query: 1619 ELAAAVDAANGE 1630 LA + GE Sbjct: 4727 ALAVRAEQHAGE 4738 Score = 42.0 bits (97), Expect = 0.75 Identities = 23/72 (31%), Positives = 41/72 (56%), Gaps = 1/72 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E + + E+L + + D+++FALGG+S++A + ++ G AL P ++FE T+A Sbjct: 3608 EEVVAGIFAEVLGLERVGLDDDFFALGGNSLVATQVVSRLGAALDTRVPVRVIFEASTVA 3667 Query: 1619 ELAAAVDAANGE 1630 LA + GE Sbjct: 3668 ALAVRAEQHAGE 3679 Score = 40.4 bits (93), Expect = 2.2 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGA-LGLPFPPAMVFEHMTI 1617 TE L +L ++L + I +N+F LGG+S+IA + A+ A LG +FE T+ Sbjct: 2550 TEYVLAEILADVLGASRIGMSDNFFDLGGNSLIATRVVARINAELGTGLNVRSLFEAPTV 2609 Query: 1618 AELAAAVD----AANGEPVVEADPPP 1639 LA VD A P + + P P Sbjct: 2610 GVLATVVDRTHAGAGPRPTLVSGPRP 2635 >tr|Q1D6A0|Q1D6A0_MYXXD Tax_Id=246197 SubName: Full=Non-ribosomal peptide synthetase;[Myxococcus xanthus] Length = 11939 Score = 765 bits (1975), Expect = 0.0 Identities = 528/1494 (35%), Positives = 765/1494 (51%), Gaps = 72/1494 (4%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL+ ++P NI +A RL+G + D L A+ ++V RH +LRTT+ + Sbjct: 2158 LSFAQQRLWFLEQLEPGSPVYNIPLAIRLSGALRVDALERALRELVRRHEVLRTTFRSE- 2216 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 G P Q+ S E DL+ L E +++ L +E R FDL + LR +++ Sbjct: 2217 GGTPVQIVSHQAENALPVVDLSSLSSEAAEAEVDRLLREESLRGFDLPSGPLLRTRLLKR 2276 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYNDL------PINDPAAQFLSVEVLQNSA 217 E VLL +HHI D S V EL+A Y P+ + Q+ Q + Sbjct: 2277 SEAEHVLLANMHHIVSDGWSMGVIVRELAALYGAFREGQPSPLPELDVQYGDFSAWQRAW 2336 Query: 218 APSVA---DVGYWAETLR---XXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFA 271 S A + +W + L + R A V +P L S V+ A Sbjct: 2337 LESGALQRQLDWWRQQLEGAPHVLSIPTDRPLPAVQTFRGANLPV-SIPPALSSGVKALA 2395 Query: 272 RKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGA-AAGALGYFGNTLLLRITTR 330 ++ A+PFMVLLA + VL+ RY+G D +V PV R+ A G +G+F NTL LR Sbjct: 2396 QRHGATPFMVLLAGFQVLLARYSGQDDLVVGTPVAGRNRAETEGLIGFFVNTLALRARAS 2455 Query: 331 SQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGG 390 ++ F + + EV++ L +AHQ V +++V E PER L ++ F+++ + Sbjct: 2456 AEKPFLTLLREVKDAALGAYAHQDVPFEQLVEELQPERTLSHSP--LFQVMFSLQNTPVP 2513 Query: 391 LAL-DGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQL 448 AL G+ + + AA L+L + PD S FEY L V +M H+L L Sbjct: 2514 EALVPGLSMSAMDTEIGAAKFFLTLALEDLPDGFSGVFEYNADLFEPATVQRMAAHWLTL 2573 Query: 449 VDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXX 508 ++ A+A P+R LS L +L ER +L + + E P T V Sbjct: 2574 LEAAVASPDRRLSDLPLLSPLERHQLLVEWNDTTTEYPRDTPV-HVQLADLATRIPETVA 2632 Query: 509 XVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYL 568 + +LT++EL R+ LA G GPE +GL S E +V +LA+L+AG A++ Sbjct: 2633 LAWEGGQLTFAELMARSRLLAAHLRSLGVGPEVRVGLFARRSPELVVGLLAILEAGGAWV 2692 Query: 569 PIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLP-LSDSDRLRPLRPG--- 624 P++P P ER+ ++ DA P ++ + L R + +P + D L + G Sbjct: 2693 PLEPDAPRERLARILEDAAPAVLLTQRAL----RDLVPATSMPVVVFEDDLGSVAAGAWE 2748 Query: 625 ------HLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDA 678 + AYV++TSGSTGRPKGV VSH A+A H F+A + DR LQ +S FDA Sbjct: 2749 ASAVADNAAYVLFTSGSTGRPKGVLVSHRALARHTAWFIAALKLGTGDRVLQKASAGFDA 2808 Query: 679 SLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQW 738 ++ ++ TL GA+L++ P A D + + R+ VT+ + Sbjct: 2809 AVPELLATLVSGARLVIAPPAAESDTEVLLAALERQQVTMLQLVPSQLRVLLAHEDVARA 2868 Query: 739 RQLRHVPVGGEALPGEVADRFAGYFDAEL-RNHYGPTEAVVCSTHMVVTGSHGARVVPIG 797 LR + GGEALP E+ + + L N YGPTE V +T + PIG Sbjct: 2869 AGLRVLVSGGEALPVELVHQARERLPSTLIINAYGPTETTVDATAWLGGDLSEGPFAPIG 2928 Query: 798 VPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN--PGMR 855 P N AYVLD Q PVP V GEL++GG LARGY+GRP LTA+RF+ D PG R Sbjct: 2929 RPIANTQAYVLDAQGQPVPVGVPGELFVGGDGLARGYVGRPDLTAERFVPDALGRMPGAR 2988 Query: 856 LYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEA 915 LYRTGD VR G LEF+GR D QVK+RG R+E GEVE V+ HPAV +VV+ + + Sbjct: 2989 LYRTGDQVRWRSGGSLEFLGRVDTQVKVRGHRVEPGEVEVVLAEHPAVHVAVVVSRKDAS 3048 Query: 916 G-PMLAAYLVP--AAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALP 972 L AY+VP A+ VD +RA A +P MVP F V+ +P+ SGK+DR+ALP Sbjct: 3049 NETRLVAYVVPGDASGAVDATALRAFLAERLPSAMVPSWFVVLESLPLLPSGKVDRKALP 3108 Query: 973 AP-TPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRA 1031 AP ++ R+Y P T TE +C F+++ G +RVG D FF LGGHSLLA +LV+++R+ Sbjct: 3109 APDVDVSERQYVAPRTPTEELLCGFFSRVLGVERVGIHDGFFELGGHSLLATQLVSRVRS 3168 Query: 1032 EFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSAR 1091 F V+L +R +F+APT A LA R+ + R+ E MP+ A P R Sbjct: 3169 AFRVELALRELFEAPTVAELARRIDQAKRSGAE----------MPMLRSPAVP------R 3212 Query: 1092 PQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTN 1151 + LPLS +Q WF +++ +N+ ++ GP RHE+LRT Sbjct: 3213 ARELPLSFAQQRLWFLDQLQPGSAFYNVSAVVKLTGPLDPIALEWSFEELVRRHESLRTT 3272 Query: 1152 FDEHEGVPYQIVHPSRTVQLAV---RAIDQDEFDDVSTQL----RRHVFTPESGPLLQAN 1204 F +G P Q++ T+ AV A+D E D + +L + F + GPLL+A Sbjct: 3273 FRAKDGTPVQVISAEPTLAFAVVSLEALDDTERDAAAKRLAEEEAQRPFDLKKGPLLRAT 3332 Query: 1205 LLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVW 1264 LL L HVL+L++HHIVSD S+ I+ ++ Y Q LP+Q+ DYAVW Sbjct: 3333 LLQLREREHVLVLVMHHIVSDEWSMGILVREVSALYEPLSQGQRSSLPDLPLQYGDYAVW 3392 Query: 1265 QRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALT 1324 Q + + +L YWR LAG P +++ TD+ RP + RG + + P+ AA+ Sbjct: 3393 QHEWLADDVLEAQLGYWRQQLAGSPSALALPTDKPRPVMQTFRGSMQEALWPSELWAAVK 3452 Query: 1325 QLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRT 1384 L +R GAT FM+ AA VL + D+++GSP+A R T L+G F N +VLRT Sbjct: 3453 ALGQREGATPFMVLLAAFQTVLSRYSDQDDVSVGSPIAGRTREETEGLIGFFVNTLVLRT 3512 Query: 1385 DLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDW 1444 +S + R +L R+ L A AHQ++P E+LVE L P R LSR+PLFQ L + + Sbjct: 3513 KVSPVSSFRELLAQVREVTLGAYAHQDVPFEKLVEELQPERDLSRSPLFQVTLTLQNTPF 3572 Query: 1445 ALVP-RDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 + V R+LT G F+++LL P G L V V N+DL++ Sbjct: 3573 SEVQLRELTLTG-VDAEEKTSKFDLSLL-----AEEVPHG-LSVAVNYNSDLFK 3619 Score = 744 bits (1921), Expect = 0.0 Identities = 502/1435 (34%), Positives = 739/1435 (51%), Gaps = 69/1435 (4%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++P N+ VA RL G++D L + +++V RH LRTT+ Sbjct: 8520 LSFAQQRLWFLDQLEPGSAFYNVPVAVRLTGVLDVAALRRSFDELVRRHESLRTTFRAQ- 8578 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIES--LAADEFGRPFDLTNELPLRITVI 161 +G P Q+ SD R E L R E +E+ LA E RPF+L LR T++ Sbjct: 8579 DGMPVQIVSDTASN--RLEVLARGTPDDGEGGLETKRLAEQEALRPFNLETGPLLRATLL 8636 Query: 162 RTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN------DLPINDPAAQFLSVEVLQN 215 + + VL+LV+HHI D S V EL A Y + P+ + Q+ V Q Sbjct: 8637 KEGEEAHVLVLVMHHIVSDGWSMGVLVRELVALYEAYSQGRESPLAELEVQYADYAVWQR 8696 Query: 216 SAAPSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQR---RVRPLPAGLFSRVED 269 +GYW + L A P + R R P GL+ V+ Sbjct: 8697 GWLKGEVLEEQLGYWRKQLAGAPAALELP-TDKARPAVQTYRGDTRGLEWPKGLWEGVKG 8755 Query: 270 FARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFGNTLLLRIT 328 A++ SA+PFMVLLAA+ V++ RY D V + R+ A G +G+F NTL+LR Sbjct: 8756 LAQRESATPFMVLLAAFQVVLSRYARQEDVCVGTAIANRTRAETEGLIGFFVNTLVLRTQ 8815 Query: 329 TRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFNMRKS 387 + +F + +VRE L +AHQ V +R+V E PER + R + ++ + N Sbjct: 8816 VSAASSFRELLAQVREVTLGAYAHQEVPFERLVEELQPERDLSRSPLFQVMLVLQNA--P 8873 Query: 388 AGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYL 446 G ++L G+ + A + L+L ++ + +S E+ L + + ++L H Sbjct: 8874 GGAVSLPGLQLEAAESSAKTSKFDLTLGLSETDEGLSGGLEFNSDLFEAETMARLLEHLR 8933 Query: 447 QLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXX 506 L+D A+ PE L+ L ++G+ E+ ++ G P + Sbjct: 8934 VLLDAAVTRPETRLAELPLMGSEEQQRLMKAWSGATAHYPREASLAQLFDAQAQRTPDAV 8993 Query: 507 XXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAA 566 D LTY+EL+RR N+LA G GPE +GL + S+E +V++L +LKAG Sbjct: 8994 AVEYEDR-RLTYAELNRRGNQLAHHLRSMGVGPEVRVGLCVERSLELVVSVLGILKAGGV 9052 Query: 567 YLPIDPAYPDERIDYLITDARPQTVIGRPEL-------DVAERAAADNS-DLPLSDSDRL 618 Y+P+D +YP ER+ ++ +A ++G+ +L D R D + ++ + Sbjct: 9053 YVPLDASYPLERLAWMKQEAGVTLLVGQQKLLESMGLNDTESRVCVDTEWETRIAHQLQT 9112 Query: 619 RP---LRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 P + G+LAYV++TSGSTG PKGV V H A++ V G E+ WLQ + +S Sbjct: 9113 TPSANVGGGNLAYVMFTSGSTGNPKGVGVPHRAVSRLVLGTDFAH-FGPEEVWLQLAPIS 9171 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FDAS +++ L GA+L+V P + + + GVT Sbjct: 9172 FDASTLEVWGALLHGAKLVV-YPAGTPSLEELGRKLESSGVT-SLWLTAALFEQMQARQP 9229 Query: 736 XQWRQLRHVPVGGEALPG-EVADRFAGYFDAELRNHYGPTE-AVVCSTHMVVTGSHGARV 793 +R + GG+ALP V +R A L N YGPTE ST+ + Sbjct: 9230 KALASVRQLLAGGDALPVLRVKERLAA--GGVLINGYGPTENTTFSSTYRMERPEEVGAS 9287 Query: 794 VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPG 853 V IG P +N AYVLD + PVP V GELY+GG LA GY+GRP LTA+RF+ +P+ G Sbjct: 9288 VSIGRPVKNTVAYVLDMGMRPVPVGVPGELYVGGDGLAVGYVGRPELTAERFVPNPYGEG 9347 Query: 854 MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA-EE 912 RLYRTGD+VR G LEF+GRAD QVK+RG+RIELGEVE+ + H V +VVA E+ Sbjct: 9348 ERLYRTGDVVRWLSNGTLEFLGRADTQVKVRGYRIELGEVEAALAQHSGVSEAVVVARED 9407 Query: 913 TEAGPMLAAYLVP-AAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRAL 971 G L AY+ ++ +R+H +PEYMVP A+ V+ +P+T +GK+DR+AL Sbjct: 9408 GGEGKRLVAYVTARTGTSLESSALRSHMKQRLPEYMVPSAYVVLESLPLTPNGKVDRKAL 9467 Query: 972 PAPTPIA--TRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQI 1029 PAP T ++ P TATE + SIFA++ +RV ++ FF LGGHSLLA +LV+++ Sbjct: 9468 PAPDAQGPKTAHFKAPRTATEEKLASIFAEVLNVERVSVDEDFFELGGHSLLATQLVSRV 9527 Query: 1030 RAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKS 1089 R F V+L +RT+F++ + LA LD+ + L P V++ Sbjct: 9528 REAFRVELPLRTVFESRSVETLARW------------LDSASGVAAGL----RAPPLVRA 9571 Query: 1090 ARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALR 1149 +R LPLS +Q WF ++++ +N+P+A++ G RHEALR Sbjct: 9572 SRDGALPLSFAQQRLWFLHQLDPDSAFYNVPVAVKLSGALDVAALERSFHSLVLRHEALR 9631 Query: 1150 TNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV-------FTPESGPLLQ 1202 T F GVP Q++ P+ L + + + + +++R F E+GPLL+ Sbjct: 9632 TTFRSEAGVPTQVISPAGRGALEFVDLSALQGSEKTLEVQRRTELQTLRPFNLETGPLLR 9691 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYA 1262 A LL G + HVL+L++HHIVSD S+ ++ +L+ Y A Q L +Q+ADYA Sbjct: 9692 ATLLKEGEEAHVLVLVMHHIVSDGWSMGVLVRELVALYEAYSQGRESPLAELEVQYADYA 9751 Query: 1263 VWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAA 1322 VWQR + + +L YWR LAG P + + TD+ARP V RG+ P Sbjct: 9752 VWQRGWLKGEVLEEQLGYWRKQLAGAPAALELPTDKARPAVQTYRGDTRGLEWPKELWEG 9811 Query: 1323 LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVL 1382 + L +R AT FM+ AA VVL + D+++GSP+A R T +L+G F N +VL Sbjct: 9812 VKGLGQRENATPFMVLLAAFQVVLSRYARQDDVSVGSPIANRTRAETEELIGFFVNSLVL 9871 Query: 1383 RTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNML 1437 RT L G+P+ R +L R+ L A AHQE+P ERLVE L P R LSR+PLFQ ML Sbjct: 9872 RTRLDGNPSFRELLAQVREVTLGAYAHQEVPFERLVEELQPERDLSRSPLFQVML 9926 Score = 744 bits (1920), Expect = 0.0 Identities = 518/1509 (34%), Positives = 751/1509 (49%), Gaps = 82/1509 (5%) Query: 34 PGICPGERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHA 93 P + LS Q+R+WFL + P N+ +L G +D L + ++V RH Sbjct: 3208 PAVPRARELPLSFAQQRLWFLDQLQPGSAFYNVSAVVKLTGPLDPIALEWSFEELVRRHE 3267 Query: 94 ILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNE 153 LRTT+ +G P QV S + + + L L + + + LA +E RPFDL Sbjct: 3268 SLRTTFRAK-DGTPVQVISAEPTLAFAVVSLEALDDTERDAAAKRLAEEEAQRPFDLKKG 3326 Query: 154 LPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLP------INDPAAQF 207 LR T+++ R E VL+LV+HHI D+ S + E+SA Y L + D Q+ Sbjct: 3327 PLLRATLLQLREREHVLVLVMHHIVSDEWSMGILVREVSALYEPLSQGQRSSLPDLPLQY 3386 Query: 208 LSVEVLQNS-AAPSV--ADVGYWAETLRXXXXXXXXXGVSGANPCR---RAQRRVRPLPA 261 V Q+ A V A +GYW + L P R + P+ Sbjct: 3387 GDYAVWQHEWLADDVLEAQLGYWRQQLAGSPSALALP-TDKPRPVMQTFRGSMQEALWPS 3445 Query: 262 GLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFG 320 L++ V+ ++ A+PFMVLLAA+ ++ RY+ D V P+ R+ G +G+F Sbjct: 3446 ELWAAVKALGQREGATPFMVLLAAFQTVLSRYSDQDDVSVGSPIAGRTREETEGLIGFFV 3505 Query: 321 NTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRL 380 NTL+LR +F + +VRE L +AHQ V +++V E PER DL Sbjct: 3506 NTLVLRTKVSPVSSFRELLAQVREVTLGAYAHQDVPFEKLVEELQPER------DLSRSP 3559 Query: 381 GFNMRKSAGGLALDGVVVRQLGLGAVAAH-----LPLSLTIALDPDDVSVEFEYQQQL-S 434 F + + V +R+L L V A LSL P +SV Y L Sbjct: 3560 LFQVTLTLQNTPFSEVQLRELTLTGVDAEEKTSKFDLSLLAEEVPHGLSVAVNYNSDLFK 3619 Query: 435 SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXX 494 + ++++L H +D A++ PE L L ++G+ ER+ ++ + G E P + Sbjct: 3620 AATMERLLGHLRVFLDAAVSAPETRLLDLPLMGSEERERLVKEWSGTASEYPRDASLSVL 3679 Query: 495 XXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFI 554 D+ LTY+EL+RRAN+LA G G GPE +GL + S+E + Sbjct: 3680 FEQQVQRTPDAVAVEYEDQ-RLTYAELNRRANQLAHHLRGMGVGPEVRVGLCVERSLELV 3738 Query: 555 VAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNS------ 608 V++L +LKAG Y+P+D +YP ER+ ++ ++ ++ + +L A+ AA Sbjct: 3739 VSLLGILKAGGVYVPLDASYPLERLAWMKQESGVAVLVAQEKL--ADEVAAGGELVVCVD 3796 Query: 609 ---DLPLSDSDRLRP---LRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTM 662 D ++ + P + G+LAYV++TSGSTG+PKGV V H A++ V G Sbjct: 3797 TEWDSQIAHHPQTTPSANVCGGNLAYVMFTSGSTGKPKGVGVPHRAVSRLVLGTDFAH-F 3855 Query: 663 TAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXX 722 E+ WLQ + +SFDAS +++ L GA+L+V P + + + GVT Sbjct: 3856 GPEEVWLQLAPISFDASTLEVWGALLHGAKLVV-YPAGTPSLEELGRKLESSGVT-SLWL 3913 Query: 723 XXXXXXXXXXXXXXQWRQLRHVPVGGEALP-GEVADRFAGYFDAELRNHYGPTE-AVVCS 780 +R + GG+ALP V +R A L N YGPTE S Sbjct: 3914 TAALFEQMQARQPKALANVRQLLAGGDALPVSRVKERLAA--GGLLFNGYGPTENTTFSS 3971 Query: 781 THMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTL 840 T+ + V IG P +N AYVLD + PVP V GELY+GG LA GY+GRP L Sbjct: 3972 TYRMEKPEEVGVSVSIGRPVKNTVAYVLDAGMRPVPVGVPGELYVGGDGLAVGYVGRPEL 4031 Query: 841 TAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTH 900 TA+RF+ PF G RLYRTGD+VR G LEF+GRAD QVK+RG+RIELGEVE+ + H Sbjct: 4032 TAERFVPSPFGEGERLYRTGDVVRWLGNGTLEFLGRADTQVKVRGYRIELGEVEAALAQH 4091 Query: 901 PAVRHCLVVAEETEA-GPMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEI 958 V +VVA E G L AY+ A +D +R+H +PEYMVP A+ V+ + Sbjct: 4092 GGVNEAVVVAREDGGEGKRLVAYVTAQEGASLDTGALRSHMKQRLPEYMVPSAYVVLEAL 4151 Query: 959 PMTVSGKLDRRALPAPTPIATR--RYREPETATERWICSIFAQLFGRQRVGAEDSFFGLG 1016 P+T +GK+DR+ALP P + + P TATE + SIFA++ +RV ++ FF LG Sbjct: 4152 PLTPNGKVDRKALPVPDAQGPKAAHFEAPRTATEEKLASIFAEVLNVERVSVDEDFFELG 4211 Query: 1017 GHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMP 1076 GHSLLA +LV+++R F V+L +R +F+APT LA RL E + + +P Sbjct: 4212 GHSLLATQLVSRVREAFHVELPLRDVFEAPTVEKLAQRL--------ETEPNGTQVLHVP 4263 Query: 1077 LDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXX 1136 + R G LPLS +Q WF ++E +N+P+A+ G Sbjct: 4264 PPTRVERTG--------SLPLSFAQQRLWFLDQLEPGSSSYNIPIAVTLTGTVQVDALEQ 4315 Query: 1137 XXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAV-------RAIDQDEFDDVSTQLR 1189 RHE+LRT F G P Q++ VQL V A E + +Q Sbjct: 4316 AFKALVLRHESLRTTFQSSGGEPAQVIAEESEVQLRVVDLRDLSEADRAPEVQRLISQEA 4375 Query: 1190 RHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAP 1249 H F GPLL+ LL L HVL+L++HHIVSD S+ ++ ++ Y A Q + Sbjct: 4376 AHPFNLARGPLLRTVLLKLSEQEHVLVLVMHHIVSDGWSMGVLVREVAALYEACSQGLSS 4435 Query: 1250 QWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGE 1309 LP+Q+ADYAVWQR + +++L +W+ L G + + TD+ RP V G Sbjct: 4436 PLPELPLQYADYAVWQREWLQGEVLESQLAWWKGQLQGASQALELPTDKPRPAVQTFHGA 4495 Query: 1310 VVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPAT 1369 P ++ LA R GAT FM+ AA VL + G D+ +GSP+A R T Sbjct: 4496 SRDVQWPRDLWESVKVLAHREGATPFMVLLAAFQTVLSRYSGQDDLCVGSPIANRTRAET 4555 Query: 1370 AQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSR 1429 L+G F N +VLR L G+PT R +L R+ L A AHQ++P ERLVE L P R LSR Sbjct: 4556 EGLIGFFVNTLVLRARLDGNPTFRELLAQVRERTLGAYAHQDIPFERLVEELKPDRDLSR 4615 Query: 1430 NPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQV 1489 +PLFQ M F ++ V L G T+ + + + L + ++ TP G L V Sbjct: 4616 SPLFQVM--FILQNTPTVELHLPG---LTLAGMDGDSRTSKFDLTLELTETPQG-LSVSA 4669 Query: 1490 IANADLYEP 1498 + N+DL+EP Sbjct: 4670 VYNSDLFEP 4678 Score = 742 bits (1916), Expect = 0.0 Identities = 521/1506 (34%), Positives = 749/1506 (49%), Gaps = 96/1506 (6%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL +DP + + N+ R+ G +D L + +V RH LRTT+ + Sbjct: 1100 LSFAQQRLWFLAQLDPANTSYNLWAPVRVTGALDVGALARSFEALVRRHEALRTTFRAEG 1159 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 G P QV S + +V DL+ LPE E ++ E GRPF L LR +++ Sbjct: 1160 -GSPVQVISAETQVPLEVVDLSVLPEGEREASAKARTEAEVGRPFQLEQGPLLRTVLLKL 1218 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPA------AQFLSVEVLQNSA 217 E VL+LV+HHI D S + E++A Y L PA Q+ + Q Sbjct: 1219 SEQEHVLVLVMHHIVSDYWSMGILVREVAALYEALSQGRPAQLPELSVQYADFAMWQRDW 1278 Query: 218 APSV---ADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP---LPAGLFSRVEDFA 271 + + YW + L P + R P L+ VE Sbjct: 1279 LKGQVLESQLAYWRKQLAGAPRALELP-TDKPRPATQTFRGANLHVLWPKALWREVESLG 1337 Query: 272 RKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFGNTLLLRITTR 330 R+ +PFMVLLAA+ ++ RY+G D V P+ RS + G +G+F NTL+LR Sbjct: 1338 RREGVTPFMVLLAAFQTVLSRYSGQDDVSVGAPIAGRSHSETEGLIGFFVNTLVLRSKLS 1397 Query: 331 SQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFNMRKS-A 388 +F + + +VRE L +AHQ V +++V E PER + R L ++ ++ + A Sbjct: 1398 PALSFRALLGQVREVTLGAYAHQDVSFEKLVEELQPERDLSRSP---LFQVTLTLQNTPA 1454 Query: 389 GGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSV-LVDQMLVHYLQ 447 + L G+ ++ L + LSL + D V Y L +D+ML H Sbjct: 1455 AEVQLRGITLKGLAAEEKTSKFDLSLVVEEVLDGVVAMVNYNSDLFEAGTMDRMLGHLRV 1514 Query: 448 LVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXX 507 L++ A+A PE+ L+ L ++G+ ER ++ + G E P + Sbjct: 1515 LLEAAVAAPEQRLAELPLMGSEERQRLVKEWSGTASEYPRDASLSVLFDAQVQRTPDAVA 1574 Query: 508 XXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAY 567 D LTY+EL RRAN+LA G G GPE +GL + S+E +V++L +LKAG Y Sbjct: 1575 VEYEDR-RLTYAELSRRANQLAHHLKGMGVGPEVRVGLCVERSLELVVSVLGILKAGGVY 1633 Query: 568 LPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDS--DRLRPLRP-- 623 +P+D +YP ER+ ++ +A ++ + +L A+ AA + D+ D L+P Sbjct: 1634 VPLDASYPLERLAWMKAEAGVALLVAQEKL--ADEVAAGGELVVCVDTEWDTQIALQPEV 1691 Query: 624 --------GHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 G+LAYV++TSGSTG+PKGV V H A++ V G E+ WLQ + +S Sbjct: 1692 APSTHVGGGNLAYVMFTSGSTGKPKGVGVPHRAVSRLVLGTDFAH-FGPEEVWLQLAPIS 1750 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FDAS +++ L GA+L+V P + + + GVT Sbjct: 1751 FDASTLEVWGALLHGAKLVV-YPAGTPSLEELGRKLKSSGVT-------SLWLTAALFEQ 1802 Query: 736 XQWRQ------LRHVPVGGEALP-GEVADRFAGYFDAELRNHYGPTE-AVVCSTHMVVTG 787 Q RQ +R + GG+ALP V +R A L N YGPTE ST+ + Sbjct: 1803 MQARQPKALDSVRQLLAGGDALPVSRVKERLAA--GGLLINGYGPTENTTFSSTYRMERP 1860 Query: 788 SHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIA 847 V IG P +N AYVLD + PVP V GELY+GG LA GY+GRP LTA+RF+ Sbjct: 1861 EEVGASVSIGRPVKNTVAYVLDGVMRPVPVGVPGELYVGGDGLAVGYVGRPELTAERFVP 1920 Query: 848 DPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCL 907 +P+ G RLYRTGD+VR G LEF+GRAD QVK+RG+RIELGEVE+ + H V + Sbjct: 1921 NPYGEGERLYRTGDMVRWLGNGTLEFLGRADTQVKVRGYRIELGEVEAALAQHGGVNEAV 1980 Query: 908 VVAEETEA-GPMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGK 965 VVA E G L AY+ A++ +R+H +PEYMVP A+ V+ +P+T +GK Sbjct: 1981 VVAREDGGEGKRLVAYVTAQEGAELASSALRSHMKQRLPEYMVPSAYVVLESLPLTPNGK 2040 Query: 966 LDRRALPAPTPIA--TRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAA 1023 +DR+ALPAP T + P TATE+ + SIF ++ +RVG + FF LGGHSLLA Sbjct: 2041 VDRKALPAPEAQGPKTAHFEAPRTATEQKLASIFTEVLNVERVGLDGDFFELGGHSLLAT 2100 Query: 1024 RLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRAR 1083 +LV+++R F V+L +R +F++PT LA RL E + +L A Sbjct: 2101 QLVSRVRESFQVELPLRDVFESPTVEKLALRLEE-----MQAGASSLHA----------- 2144 Query: 1084 PGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXX 1143 P +S R LPLS +Q WF ++E +N+PLA+R G Sbjct: 2145 PPLKRSPRLGALPLSFAQQRLWFLEQLEPGSPVYNIPLAIRLSGALRVDALERALRELVR 2204 Query: 1144 RHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAID---------QDEFDDVSTQLRRHVFT 1194 RHE LRT F G P QIV S + A+ +D + E D + + F Sbjct: 2205 RHEVLRTTFRSEGGTPVQIV--SHQAENALPVVDLSSLSSEAAEAEVDRLLREESLRGFD 2262 Query: 1195 PESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDIL 1254 SGPLL+ LL HVLL +HHIVSD S+ ++ +L Y A + L Sbjct: 2263 LPSGPLLRTRLLKRSEAEHVLLANMHHIVSDGWSMGVIVRELAALYGAFREGQPSPLPEL 2322 Query: 1255 PIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFS 1314 +Q+ D++ WQR ES Q +LD+WR L G P +S+ TDR P V RG + S Sbjct: 2323 DVQYGDFSAWQRAWLESGALQRQLDWWRQQLEGAPHVLSIPTDRPLPAVQTFRGANLPVS 2382 Query: 1315 VPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVG 1374 +P A + + LA+R+GAT FM+ A V+L + G D+ +G+PVA R T L+G Sbjct: 2383 IPPALSSGVKALAQRHGATPFMVLLAGFQVLLARYSGQDDLVVGTPVAGRNRAETEGLIG 2442 Query: 1375 LFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQ 1434 F N + LR S + ++L +D L A AHQ++P E+LVE L P R LS +PLFQ Sbjct: 2443 FFVNTLALRARASAEKPFLTLLREVKDAALGAYAHQDVPFEQLVEELQPERTLSHSPLFQ 2502 Query: 1435 NMLNFRGE--DWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIAN 1492 M + + ALVP ++ + A FL + + P G V N Sbjct: 2503 VMFSLQNTPVPEALVP-------GLSMSAMDTEIGAAKFFLTLALEDLPDGFSGV-FEYN 2554 Query: 1493 ADLYEP 1498 ADL+EP Sbjct: 2555 ADLFEP 2560 Score = 741 bits (1912), Expect = 0.0 Identities = 498/1437 (34%), Positives = 733/1437 (51%), Gaps = 69/1437 (4%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL +DPD N+ VA +L+G +D L + + +V RH LRTT+ + Sbjct: 9579 LSFAQQRLWFLHQLDPDSAFYNVPVAVKLSGALDVAALERSFHSLVLRHEALRTTFRSEA 9638 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 G P QV S DL+ L + +++ + RPF+L LR T+++ Sbjct: 9639 -GVPTQVISPAGRGALEFVDLSALQGSEKTLEVQRRTELQTLRPFNLETGPLLRATLLKE 9697 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYN------DLPINDPAAQFLSVEVLQNSA 217 + VL+LV+HHI D S V EL A Y + P+ + Q+ V Q Sbjct: 9698 GEEAHVLVLVMHHIVSDGWSMGVLVRELVALYEAYSQGRESPLAELEVQYADYAVWQRGW 9757 Query: 218 APSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQR---RVRPLPAGLFSRVEDFA 271 +GYW + L A P + R R P L+ V+ Sbjct: 9758 LKGEVLEEQLGYWRKQLAGAPAALELP-TDKARPAVQTYRGDTRGLEWPKELWEGVKGLG 9816 Query: 272 RKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLLRITTR 330 ++ +A+PFMVLLAA+ V++ RY D V P+ R+ A L G+F N+L+LR Sbjct: 9817 QRENATPFMVLLAAFQVVLSRYARQDDVSVGSPIANRTRAETEELIGFFVNSLVLRTRLD 9876 Query: 331 SQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFNMRKSAG 389 +F + +VRE L +AHQ V +R+V E PER + R + ++ + N G Sbjct: 9877 GNPSFRELLAQVREVTLGAYAHQEVPFERLVEELQPERDLSRSPLFQVMLVLQNT--PGG 9934 Query: 390 GLALDGVVVRQLGLGAVAAHLPLSLTI-ALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQ 447 ++L G+ + + L+L + A D ++ E+ L + ++++L H Sbjct: 9935 AVSLPGLKLEAAESTGKTSKFDLTLGLGASSTDGLTGALEFNSDLFEAETMERLLGHLRV 9994 Query: 448 LVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXX 507 L++ A+A PE L+ L ++G+ ER ++ + G P + Sbjct: 9995 LLEAAVAAPETRLAELPLMGSEERQRLVKEWSGTASTYPRDASLSVLFEQQAQRTPDAVA 10054 Query: 508 XXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAY 567 D+ LTY+EL+RRAN+LA G GPE +GL + S+E +V++L +LKAG Y Sbjct: 10055 VEYEDQ-RLTYAELNRRANQLAHHLRRMGVGPEVRVGLCVERSLELVVSVLGILKAGGVY 10113 Query: 568 LPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNS---------DLPLSDSDRL 618 +P+D +YP ER+ ++ +A ++ + +L A+ A + D ++ + Sbjct: 10114 VPLDASYPLERLAWMKQEAGVAVLVAQEKL--ADEVATGSELVVCVDTEWDTQIAHHPQT 10171 Query: 619 RP---LRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 P + G+LAYV++TSGSTG+PKGV V H A++ V G E+ WLQ + +S Sbjct: 10172 TPSANVGGGNLAYVMFTSGSTGKPKGVGVPHRAVSRLVLGTDFAH-FGPEEVWLQLAPIS 10230 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FDAS +++ L G++L+V P + + + GVT Sbjct: 10231 FDASTLEVWGALLHGSRLVV-YPAGTPSLEELGRNLESSGVT-SLWLTAALFEQMQARQP 10288 Query: 736 XQWRQLRHVPVGGEALP-GEVADRFAGYFDAELRNHYGPTE-AVVCSTHMVVTGSHGARV 793 +R + GG+ALP V +R A L N YGPTE ST+ + + Sbjct: 10289 KALASVRQLLAGGDALPVSRVKERLAA--GGVLINGYGPTENTTFSSTYRMESPEEVGAS 10346 Query: 794 VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPG 853 V IG P +N YVLD + PVP V GELY+GG LA GY+GRP LTA+RF+ +P+ G Sbjct: 10347 VSIGRPVKNTVVYVLDAGMRPVPVGVPGELYVGGDGLAMGYVGRPELTAERFVPNPYGDG 10406 Query: 854 MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEET 913 RLYRTGD+VR G LEF+GRAD QVK+RG+RIELG+VE+ + H V +VVA E Sbjct: 10407 ERLYRTGDVVRWLRNGTLEFLGRADTQVKVRGYRIELGDVEAALAQHSGVSEAVVVARED 10466 Query: 914 EA-GPMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRAL 971 G L AY+ A +D +R+H +PEYMVP A+ V+ +P+T +GK+DR+AL Sbjct: 10467 GGEGKRLVAYVTAQEGATLDAGALRSHMKQRLPEYMVPSAYVVLEALPLTPNGKVDRKAL 10526 Query: 972 PAPTPIAT--RRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQI 1029 PAP T +Y P TATE+ + +IF + +RVG + FF LGGHSLLA +LV+++ Sbjct: 10527 PAPDTAGTASEKYVAPRTATEKTLAAIFVDVLKVERVGLDGDFFELGGHSLLATQLVSRV 10586 Query: 1030 RAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKS 1089 R E +L +R IF+ PT LA RL D+ + D P P V+ Sbjct: 10587 REELQAELPLRDIFECPTVEKLAQRL------------DHTSKTDGGAQP----PPLVRV 10630 Query: 1090 ARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALR 1149 +R + LPLS +Q WF ++E +N+P ++R G RHEALR Sbjct: 10631 SRDRALPLSFAQQRLWFLAQLEPDSTVYNVPASVRLSGALNVPALKQSFDALVHRHEALR 10690 Query: 1150 TNFDEHEGVPYQIVHPSRTVQLAV-------RAIDQDEFDDVSTQLRRHVFTPESGPLLQ 1202 T F G P Q++ P +L + A ++E ++ + + F ESGPLL+ Sbjct: 10691 TTFRTEGGSPVQVIDPRGGARLDIVDLRSLPAAQREEEAQRIAQEASQRPFDLESGPLLR 10750 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYA 1262 LL L HVL+L++HHIVSD S+ ++ +L Y + Q LP+Q+ADYA Sbjct: 10751 LALLALSEQDHVLVLVMHHIVSDGWSMGLLVRELTEFYASFSQGQPSHLPELPLQYADYA 10810 Query: 1263 VWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAA 1322 VWQR + + +L YW+ L G P + + TDR RP V G V FS+ A Sbjct: 10811 VWQREWLQGDVLDAQLGYWKQRLDGAPRLLELPTDRPRPAVQSLEGAYVPFSLGRELSEA 10870 Query: 1323 LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVL 1382 + LA R G T FM+ AA VL + G D+++GSP+A R T L+G F N +VL Sbjct: 10871 VHALARREGVTPFMVLLAAFQAVLARYSGQDDVSVGSPIAGRTRAETEGLIGFFVNTLVL 10930 Query: 1383 RTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 RT L G P+ R +L R+ L A AHQ++P E+LVEAL P R+LS +PLFQ ML F Sbjct: 10931 RTRLEGSPSFRELLARVREVTLGAYAHQDVPFEKLVEALRPERSLSHSPLFQVMLTF 10987 Score = 730 bits (1884), Expect = 0.0 Identities = 516/1498 (34%), Positives = 746/1498 (49%), Gaps = 82/1498 (5%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL+ + P V N+ +++G +D L + + +V RH LRTT+ D Sbjct: 5342 LSFAQQRLWFLEQLAPGSVFYNVPAVVKVSGPLDVAALERSFDALVRRHESLRTTFHADG 5401 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 G P QV + +V + EDL+ LP+A E++ + A E RPFDL LR ++R Sbjct: 5402 -GTPVQVIAPVGQVVFTVEDLSGLPDA--EQEAQRRADVEALRPFDLAKGPLLRTMLLRL 5458 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYNDL------PINDPAAQFLSVEVLQNSA 217 E +L+L++HHI D S V E++A Y P+ + A Q+ V Q Sbjct: 5459 GEREHLLVLMMHHIVSDGWSMGVLVREVAALYEAFSQGRPSPLPELAVQYPDYAVWQREW 5518 Query: 218 APSV---ADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRV---RPLPAGLFSRVEDFA 271 A +GYW + L A P + V P L+ +E Sbjct: 5519 LKGEVLEAQLGYWKQRLEGAPAALELP-TDKARPAVQTYGGVLRHEVWPKALWRDMEALG 5577 Query: 272 RKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERS-GAAAGALGYFGNTLLLRITTR 330 R+ A+PFMVLLAAY ++ +Y G D V P+ R+ G G +G+F N L+LR Sbjct: 5578 RREGATPFMVLLAAYQWVLSKYAGQEDVCVGAPIAGRAQGETEGLIGFFANMLVLRTKVS 5637 Query: 331 SQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGG 390 TF + +VRE L +AHQ V +++V E PER V L Sbjct: 5638 PASTFRELLAQVREVTLGAYAHQDVPFEKLVEELQPERDLSRSPLFQVTLTLQNTPVTEV 5697 Query: 391 LALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQ-LV 449 DG+ + + + SL + V V Y +L + L+H+L+ L+ Sbjct: 5698 KLGDGLTLSGVESEGRTSKFDFSLVVEEVQGGVVVAANYNTELFEAETVRRLLHHLRTLL 5757 Query: 450 DKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXX 509 + A+AEP + L+ L ++G+ E+ ++ + G E P + Sbjct: 5758 EAAIAEPAKRLAELPLMGSEEQHRLVKEWSGMASEYPRDASLSVLFEQQVQRTPDAVAVE 5817 Query: 510 VSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLP 569 D LTY+EL+RRAN+LA G G GPE +GL + S+E +V++L +LKAG Y+P Sbjct: 5818 YEDR-RLTYAELNRRANQLAHHLKGMGVGPEVRVGLCVERSLELVVSVLGILKAGGVYVP 5876 Query: 570 IDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDS--DRLRPLRP---- 623 +D +YP ER+ ++ +A ++ + +L A+ A + D+ D L+P Sbjct: 5877 LDASYPLERLAWMKQEAGVAVLVAQEKL--ADEVATGGELVVCVDTEWDTQIALQPEVAP 5934 Query: 624 ------GHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFD 677 G+LAYV++TSGSTG+PKGV V H A++ V G E+ WLQ + +SFD Sbjct: 5935 STHVGGGNLAYVMFTSGSTGKPKGVGVPHRAVSRLVLGTDFAH-FGPEEVWLQLAPISFD 5993 Query: 678 ASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQ 737 AS +++ L GA+L+V P + ++ + GVT Sbjct: 5994 ASTLEVWGALLHGAKLVV-YPAGTPTLEELSRKLESSGVT-SLWLTAALFEQMQARQPKA 6051 Query: 738 WRQLRHVPVGGEALPG-EVADRFAGYFDAELRNHYGPTE-AVVCSTHMVVTGSHGARVVP 795 +R + GG+ALP V +R A L N YGPTE ST+ + V Sbjct: 6052 LASVRQLLAGGDALPVLRVKERLAA--GGLLINGYGPTENTTFSSTYRMERPEEVGASVS 6109 Query: 796 IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMR 855 IG P +N AYVLD + PVP V GELY+GG LA GY+GRP LTA+RF+ PF G R Sbjct: 6110 IGRPVKNTVAYVLDMGMRPVPVGVPGELYVGGDGLAVGYVGRPELTAERFVPSPFGEGAR 6169 Query: 856 LYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA-EETE 914 LYRTGD+VR G LEF+GRAD QVK+RG+RIELGEVE+ + H V + V E+ Sbjct: 6170 LYRTGDVVRWLGNGTLEFLGRADTQVKVRGYRIELGEVEAALAQHGGVNEAVAVTREDGS 6229 Query: 915 AGPMLAAYLVPAAAQVDLEE--IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALP 972 G L AY V A V LE +R+H +PEYMVP A+ V+ +P+T +GK+DR+ALP Sbjct: 6230 EGKRLVAY-VTAQEGVSLETGALRSHMKQRLPEYMVPSAYVVLESLPLTPNGKVDRKALP 6288 Query: 973 APTPIATR--RYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIR 1030 AP + + P TATE+ + SIFA++ +RVG E FF LGGHSLLA +LV+++R Sbjct: 6289 APDAQGPKAAHFEAPRTATEQRLASIFAEVLNVERVGLEGDFFELGGHSLLATQLVSRVR 6348 Query: 1031 AEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSA 1090 E V+L +R IF++ T LA R+ + AA+ RA P +++ Sbjct: 6349 EELQVELPLRDIFESSTVGKLAERI--------DASRGTAAAE------VRAPP-LTRAS 6393 Query: 1091 RPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRT 1150 R LPLS +Q WF ++E +N+P ++ G RHE+LRT Sbjct: 6394 RSDALPLSFAQQRLWFLDQLEPGSPFYNVPSVVKLTGRLQTTALEASFSELVRRHESLRT 6453 Query: 1151 NFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV-----------FTPESGP 1199 F G P Q++ ++ Q +F ++ T+ V F E+GP Sbjct: 6454 TFRVSGGEPVQVIATD-----PLQPFQQLDFSELETERESRVRIWIEEEIQRPFNLETGP 6508 Query: 1200 LLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFA 1259 LL+A LL G + HVL+L++HHIVSD S+ ++ +L+ Y A Q L +Q+A Sbjct: 6509 LLRATLLKEGEEAHVLVLVMHHIVSDGWSMGVLVRELVALYEAYSQGRESPLAELEVQYA 6568 Query: 1260 DYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 DYAVWQR + + +L YWR LAG P + + TD+ARP V RG+ P Sbjct: 6569 DYAVWQRGWLKGEVLEEQLGYWRKQLAGAPAALELPTDKARPAVQTYRGDTRGLEWPKGL 6628 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 + LA+R AT FM+ AA VVL + D+ +G+ +A R T L+G F N Sbjct: 6629 WEGVKGLAQRESATPFMVLLAAFQVVLSRYARQEDVCVGTAIANRTRAETEGLIGFFVNT 6688 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 +VLRT +S + R +L R+ L A AHQE+P ERLVE L P R LSR+PLFQ ML Sbjct: 6689 LVLRTQVSAASSFRELLAQVREVTLGAYAHQEVPFERLVEELQPERDLSRSPLFQVMLVL 6748 Query: 1440 RGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 + V F+V L G+ + +G L + N+DL+E Sbjct: 6749 QNAPGGAVSLPGLKLEAAESTGKTSKFDVTL-----GLGESSAGGLSGALEFNSDLFE 6801 Score = 726 bits (1875), Expect = 0.0 Identities = 493/1438 (34%), Positives = 731/1438 (50%), Gaps = 67/1438 (4%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++P N+ +L G + L + +++V RH LRTT+ V + Sbjct: 6400 LSFAQQRLWFLDQLEPGSPFYNVPSVVKLTGRLQTTALEASFSELVRRHESLRTTFRV-S 6458 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 GEP QV + D +++ D + L E E ++ +E RPF+L LR T+++ Sbjct: 6459 GGEPVQVIATDPLQPFQQLDFSEL-ETERESRVRIWIEEEIQRPFNLETGPLLRATLLKE 6517 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYN------DLPINDPAAQFLSVEVLQNSA 217 + VL+LV+HHI D S V EL A Y + P+ + Q+ V Q Sbjct: 6518 GEEAHVLVLVMHHIVSDGWSMGVLVRELVALYEAYSQGRESPLAELEVQYADYAVWQRGW 6577 Query: 218 APSVA---DVGYWAETLRXXXXXXXXXGVSGANPCRRAQR---RVRPLPAGLFSRVEDFA 271 +GYW + L A P + R R P GL+ V+ A Sbjct: 6578 LKGEVLEEQLGYWRKQLAGAPAALELP-TDKARPAVQTYRGDTRGLEWPKGLWEGVKGLA 6636 Query: 272 RKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFGNTLLLRITTR 330 ++ SA+PFMVLLAA+ V++ RY D V + R+ A G +G+F NTL+LR Sbjct: 6637 QRESATPFMVLLAAFQVVLSRYARQEDVCVGTAIANRTRAETEGLIGFFVNTLVLRTQVS 6696 Query: 331 SQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFNMRKSAG 389 + +F + +VRE L +AHQ V +R+V E PER + R + ++ + N G Sbjct: 6697 AASSFRELLAQVREVTLGAYAHQEVPFERLVEELQPERDLSRSPLFQVMLVLQNA--PGG 6754 Query: 390 GLALDGVVVRQLGLGAVAAHLPLSLTIA-LDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQ 447 ++L G+ + + ++L + +S E+ L + ++++L H Sbjct: 6755 AVSLPGLKLEAAESTGKTSKFDVTLGLGESSAGGLSGALEFNSDLFEAETMERLLGHLRV 6814 Query: 448 LVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXX 507 L++ A++ PE PL+ L ++G E+ ++ + G P + Sbjct: 6815 LLETAVSAPELPLAELPLMGHEEQQRLVKEWSGTASTYPRDASLSALFEAQVQRTPDAVA 6874 Query: 508 XXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAY 567 D+ LTY+EL+RR+N+LA G GPE +GL + S+E +V++L +LKAG Y Sbjct: 6875 VEYEDQ-RLTYAELNRRSNQLAHHLRSMGVGPEVRVGLCVERSLELVVSVLGILKAGGVY 6933 Query: 568 LPIDPAYPDERIDYLITDARPQTVIGRPEL-----------DVAERAAADNSDLPLSDSD 616 +P+D +YP +R+ ++ +A ++G+ +L V D + +S+ Sbjct: 6934 VPLDASYPLKRLTWMKQEASVTLLVGQQKLLESMMLSDTESSVCVDTEWDAQIVHQPESN 6993 Query: 617 RLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSF 676 + GHLAYV++TSGSTG+PKGV V H A++ V G E+ WLQ + SF Sbjct: 6994 LRSSVAGGHLAYVMFTSGSTGKPKGVGVPHRAVSRLVLGTDFAH-FGPEEVWLQLAPTSF 7052 Query: 677 DASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXX 736 DAS +++ L GA+L+V P + + + GVT Sbjct: 7053 DASTLEVWGALLHGAKLVV-YPAGTPSLEELGRKLESSGVT-SLWLTAALFEQMQARQPK 7110 Query: 737 QWRQLRHVPVGGEALPG-EVADRFAGYFDAELRNHYGPTE-AVVCSTHMVVTGSHGARVV 794 +R + GG+ALP V +R A L N YGPTE ST+ + V Sbjct: 7111 ALASVRQLLAGGDALPVLRVKERLAA--GGLLINGYGPTENTTFSSTYRMERPEEVGASV 7168 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGM 854 IG P +N YVLD + PVP V GELY+GG LA GY+GRP LTA+RF+ +P+ G Sbjct: 7169 SIGRPVKNTVVYVLDAGMRPVPVGVPGELYVGGDGLAMGYVGRPELTAERFVPNPYGEGE 7228 Query: 855 RLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA-EET 913 RLYRTGD+VR G LEF+GRAD QVK+RG+RIELGEVE+ + H V + V E+ Sbjct: 7229 RLYRTGDVVRWLGNGTLEFLGRADTQVKVRGYRIELGEVEAALAQHGGVNEAVAVTREDG 7288 Query: 914 EAGPMLAAYLVP-AAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALP 972 G L AY+ ++ +R+H +PEYMVP A+ V+ +P+T +GK+DR+ALP Sbjct: 7289 GEGKRLVAYVTARTGTSLESSALRSHMKQRLPEYMVPSAYVVLEALPLTPNGKVDRKALP 7348 Query: 973 AP-TPIAT--RRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQI 1029 AP T + T Y P T TE I IF+Q+ G +RVG++D+FF LGGHSLLA ++V++I Sbjct: 7349 APVTMLGTPGSDYLAPRTPTEELIAGIFSQVLGVERVGSKDNFFELGGHSLLATQMVSRI 7408 Query: 1030 RAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKS 1089 R+ F ++L +R +F+APT + L+ R+ R + PL P RA +V Sbjct: 7409 RSTFRIELPLRDLFEAPTLSVLSERVDHAIRTGASITAP-------PLTP-RADGSWV-- 7458 Query: 1090 ARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALR 1149 LP S +Q W ++E +N+P LR EGP RHE+LR Sbjct: 7459 -----LPPSFAQQRLWLLDQMEQGSASYNVPAVLRVEGPLQAEVLERSFVELVRRHESLR 7513 Query: 1150 TNFDEHEGVPYQIV-------HPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQ 1202 T F +G P QI+ S ++ + A+ E + Q F E GPLL+ Sbjct: 7514 TTFSTRDGKPVQIIAAEPVLAFRSMGLESSAEAVRTAEVARLVEQEAHQRFDLERGPLLR 7573 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYA 1262 LL L HVL+L+ HHIVSD S+ ++ D+ Y A LQ LP+Q+ DYA Sbjct: 7574 VTLLKLAEQEHVLILVTHHIVSDGWSMGVLVRDVTALYEAFLQGRPSLLPELPVQYPDYA 7633 Query: 1263 VWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAA 1322 VWQR + +++L YW+ L G P + + TD+ RP RG + S P A Sbjct: 7634 VWQREWLKGEVLESQLAYWKRQLKGAPQSLELPTDKPRPAAQSFRGGHLDQSWPLALWER 7693 Query: 1323 LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVL 1382 + LA+R GAT FM+ AA VVL + D+ +GSP+A R + T L+G F N++VL Sbjct: 7694 VKALAQREGATPFMVLLAAFQVVLARYARQDDVCVGSPIAGRTQGETEGLIGFFTNMLVL 7753 Query: 1383 RTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 RT ++ T R +L R+ L A AHQ++P E+LVE L P R LSR+PLFQ L + Sbjct: 7754 RTKVAPASTFRELLAQVREVTLGAYAHQDVPFEKLVEELQPERDLSRSPLFQVTLTLQ 7811 Score = 726 bits (1875), Expect = 0.0 Identities = 513/1506 (34%), Positives = 749/1506 (49%), Gaps = 99/1506 (6%) Query: 45 SDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTE 104 S Q+R+W L M+ + N+ R+ G + + L + ++V RH LRTT+ + Sbjct: 7462 SFAQQRLWLLDQMEQGSASYNVPAVLRVEGPLQAEVLERSFVELVRRHESLRTTFST-RD 7520 Query: 105 GEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTR 164 G+P Q+ + + + +R L EA ++ L E + FDL LR+T+++ Sbjct: 7521 GKPVQIIAAEPVLAFRSMGLESSAEAVRTAEVARLVEQEAHQRFDLERGPLLRVTLLKLA 7580 Query: 165 ADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDP-----AAQFL 208 E VL+LV HHI D S V +++A Y +LP+ P ++L Sbjct: 7581 EQEHVLILVTHHIVSDGWSMGVLVRDVTALYEAFLQGRPSLLPELPVQYPDYAVWQREWL 7640 Query: 209 SVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRV---RPLPAGLFS 265 EVL++ A YW L+ P ++ R + P L+ Sbjct: 7641 KGEVLESQLA-------YWKRQLKGAPQSLELP-TDKPRPAAQSFRGGHLDQSWPLALWE 7692 Query: 266 RVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERS-GAAAGALGYFGNTLL 324 RV+ A++ A+PFMVLLAA+ V++ RY D V P+ R+ G G +G+F N L+ Sbjct: 7693 RVKALAQREGATPFMVLLAAFQVVLARYARQDDVCVGSPIAGRTQGETEGLIGFFTNMLV 7752 Query: 325 LRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFN 383 LR TF + +VRE L +AHQ V +++V E PER + R + + N Sbjct: 7753 LRTKVAPASTFRELLAQVREVTLGAYAHQDVPFEKLVEELQPERDLSRSPLFQVTLTLQN 7812 Query: 384 MR----KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSV-LV 438 K GL L GV + LSL + D V Y L + Sbjct: 7813 TPVTEVKLGDGLRLSGVESE-----GRTSKFDLSLVMEEVKDGVMAMVNYNSDLFEAGTM 7867 Query: 439 DQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXX 498 D+ML H L++ A+A PE+ L+ L ++G E+ ++ + G P + Sbjct: 7868 DRMLGHLRVLLEAAVAAPEQRLAELPLMGREEQQRLVKEWSGAASTYPRDADLSALFEAQ 7927 Query: 499 XXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAML 558 D+ LTY+EL+RRAN+LA G G GPE +GL + S+E +V++L Sbjct: 7928 VQRTPDAVAVEYEDQ-RLTYAELNRRANQLAHHLRGMGVGPEVRVGLCVERSLELVVSVL 7986 Query: 559 AVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNS---------D 609 +LKAG Y+P+D +YP ER+ ++ +A ++ + +L A+ A D Sbjct: 7987 GILKAGGVYVPLDASYPLERLAWMKHEAGVAVLVAQEKL--ADEVATGGELVVCVDTEWD 8044 Query: 610 LPLSDSDRLRP---LRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQG--FVAEWTMTA 664 ++ ++ P + G+LAYV++TSGSTG+PKGV V H A++ V G FV Sbjct: 8045 TQIAHHPQITPSANVGGGNLAYVMFTSGSTGKPKGVGVPHRAVSRLVLGTDFVH---FGP 8101 Query: 665 EDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXX 724 E+ WLQ + +SFDAS +++ L G++L+V P + + + GVT Sbjct: 8102 EEVWLQLAPISFDASTLEVWGALLHGSRLVV-YPAGTPSLEELGRNLESSGVT-SLWLTA 8159 Query: 725 XXXXXXXXXXXXQWRQLRHVPVGGEALPG-EVADRFAGYFDAELRNHYGPTE-AVVCSTH 782 +R + GG+ALP V +R A L N YGPTE ST+ Sbjct: 8160 ALFEQMQARQPKALANVRQLLAGGDALPVLRVEERLAA--GGLLINGYGPTENTTFSSTY 8217 Query: 783 MVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTA 842 + V IG P +N AYVLD + PVP V GELY+GG LA GY+GRP LTA Sbjct: 8218 RMEKPEEVGVSVSIGRPVKNTVAYVLDAGMRPVPVGVPGELYVGGDGLAVGYVGRPALTA 8277 Query: 843 QRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPA 902 +RF+ PF G RLYRTGD+VR G LEF+GRAD QVK+RG+RIELGEVE+ + H Sbjct: 8278 ERFVPSPFGEGERLYRTGDVVRWLRNGTLEFLGRADTQVKVRGYRIELGEVEAALAQHGG 8337 Query: 903 VRHCLVVA-EETEAGPMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPM 960 V +VVA E+ G L AY+ A +D +R H +PEYMVP A+ V+ +P+ Sbjct: 8338 VNEAVVVAREDGNEGKRLVAYVTAQEGASLDTGALRNHVKQRLPEYMVPSAYVVLESLPL 8397 Query: 961 TVSGKLDRRALPAPTPIA--TRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGH 1018 T +GK+DR+ALPAP T + P TATE + SIFA++ +RV ++ FF LGGH Sbjct: 8398 TPNGKVDRKALPAPDAQGPKTAHFEAPRTATEEKLASIFAEVLNVERVSVDEDFFELGGH 8457 Query: 1019 SLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLD 1078 SLLA +LV+++R V+L +R +F++PT LA +L + L PL Sbjct: 8458 SLLATQLVSRVRESLQVELPLRDVFESPTVEQLALKLGHE-------QVGGLMPQAPPL- 8509 Query: 1079 PKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXX 1138 KRA R LPLS +Q WF ++E +N+P+A+R G Sbjct: 8510 -KRA-------LRQGALPLSFAQQRLWFLDQLEPGSAFYNVPVAVRLTGVLDVAALRRSF 8561 Query: 1139 XXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRR-------H 1191 RHE+LRT F +G+P QIV + + +L V A + + + +R Sbjct: 8562 DELVRRHESLRTTFRAQDGMPVQIVSDTASNRLEVLARGTPDDGEGGLETKRLAEQEALR 8621 Query: 1192 VFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQW 1251 F E+GPLL+A LL G + HVL+L++HHIVSD S+ ++ +L+ Y A Q Sbjct: 8622 PFNLETGPLLRATLLKEGEEAHVLVLVMHHIVSDGWSMGVLVRELVALYEAYSQGRESPL 8681 Query: 1252 DILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV 1311 L +Q+ADYAVWQR + + +L YWR LAG P + + TD+ARP V RG+ Sbjct: 8682 AELEVQYADYAVWQRGWLKGEVLEEQLGYWRKQLAGAPAALELPTDKARPAVQTYRGDTR 8741 Query: 1312 QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQ 1371 P + LA+R AT FM+ AA VVL + D+ +G+ +A R T Sbjct: 8742 GLEWPKGLWEGVKGLAQRESATPFMVLLAAFQVVLSRYARQEDVCVGTAIANRTRAETEG 8801 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNP 1431 L+G F N +VLRT +S + R +L R+ L A AHQE+P ERLVE L P R LSR+P Sbjct: 8802 LIGFFVNTLVLRTQVSAASSFRELLAQVREVTLGAYAHQEVPFERLVEELQPERDLSRSP 8861 Query: 1432 LFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIA 1491 LFQ ML + P + + + + L +G+S T G L + Sbjct: 8862 LFQVMLVLQN-----APGGAVSLPGLQLEAAESSAKTSKFDLTLGLSETDEG-LSGGLEF 8915 Query: 1492 NADLYE 1497 N+DL+E Sbjct: 8916 NSDLFE 8921 Score = 710 bits (1832), Expect = 0.0 Identities = 482/1441 (33%), Positives = 711/1441 (49%), Gaps = 70/1441 (4%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++P + NI +A L G V D L A +V RH LRTT+ + Sbjct: 4276 LSFAQQRLWFLDQLEPGSSSYNIPIAVTLTGTVQVDALEQAFKALVLRHESLRTTFQ-SS 4334 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 GEP QV +++ EV R DL L EA +++ L + E PF+L LR +++ Sbjct: 4335 GGEPAQVIAEESEVQLRVVDLRDLSEADRAPEVQRLISQEAAHPFNLARGPLLRTVLLKL 4394 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVEV 212 E VL+LV+HHI D S V E++A Y +LP+ E Sbjct: 4395 SEQEHVLVLVMHHIVSDGWSMGVLVREVAALYEACSQGLSSPLPELPLQYADYAVWQREW 4454 Query: 213 LQNSAAPSVADVGYWAETLRXXXXXXXXXGVS---GANPCRRAQRRVRPLPAGLFSRVED 269 LQ S + +W L+ A R V+ P L+ V+ Sbjct: 4455 LQGEVLES--QLAWWKGQLQGASQALELPTDKPRPAVQTFHGASRDVQ-WPRDLWESVKV 4511 Query: 270 FARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFGNTLLLRIT 328 A + A+PFMVLLAA+ ++ RY+G D V P+ R+ A G +G+F NTL+LR Sbjct: 4512 LAHREGATPFMVLLAAFQTVLSRYSGQDDLCVGSPIANRTRAETEGLIGFFVNTLVLRAR 4571 Query: 329 TRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFNMRKS 387 TF + +VRE L +AHQ + +R+V E P+R + R L ++ F ++ + Sbjct: 4572 LDGNPTFRELLAQVRERTLGAYAHQDIPFERLVEELKPDRDLSRSP---LFQVMFILQNT 4628 Query: 388 AG-GLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHY 445 L L G+ + + + + L+L + P +SV Y L V +D+++ H Sbjct: 4629 PTVELHLPGLTLAGMDGDSRTSKFDLTLELTETPQGLSVSAVYNSDLFEPVTMDRLMGHL 4688 Query: 446 LQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXX 505 L++ A+ P+ L L +LGA E+ +L + + + T+ Sbjct: 4689 RVLLEAAVQTPDARLGELPLLGAVEQRRLLVEWNDTRSDFVPNTI--QALFEAQAAKTPE 4746 Query: 506 XXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGA 565 V++++ LTY L++RAN+LA G GP+ +GL + S +V + +LKAG Sbjct: 4747 ALAVVAEDSRLTYEALNQRANQLAHQLRSLGVGPDVPVGLYLDRSASAVVGLWGILKAGG 4806 Query: 566 AYLPIDPAYPDERIDYLITDARPQTVIGRPEL---------DVAERAAADNSDLPLSDSD 616 AY+P+D +P ERI +++DA Q ++ + L V A +S L S+ + Sbjct: 4807 AYVPLDVTFPVERIRSVLSDAGAQVLVTQAALAEVLRWGAGGVVRLDADASSLLERSERN 4866 Query: 617 RLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSF 676 P +LAYVI+TSGSTGRPKGVA+ H + +V+G + + S+++ Sbjct: 4867 PEPSAAPENLAYVIFTSGSTGRPKGVAIEHRQLVHYVKGVSCRLDLPESASFASVSTLAA 4926 Query: 677 DASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXX 736 D +F TL G L + + D S +A+L R V Sbjct: 4927 DLGHTAVFPTLCQGGALHLVSRECASDPSALAELFEREAVDCLKIVPAHLQALLASGNPE 4986 Query: 737 QWRQLRHVPVGGEALPGEVADRFAGYF-DAELRNHYGPTEAVVCSTHMVVTGSHGARV-- 793 + + + +GG+ + DR D E+ NHYGP+E V + V RV Sbjct: 4987 RVLPRQRLVLGGDVSDWALMDRVHELSPDLEVFNHYGPSETTVGVLTLQVERGPQGRVSA 5046 Query: 794 -VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF-- 850 VP+G P N YVLD L PVP V GEL +GG + RGYLGR LTA+RF+ D + Sbjct: 5047 SVPLGRPIPNARVYVLDAYLRPVPVGVPGELCIGGRTVGRGYLGRVDLTAERFVPDAYAE 5106 Query: 851 NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA 910 +PG R+YRTGD R G +EF+GR D+Q+K+RG+R+E+GEVE+ + HP+VR +VVA Sbjct: 5107 DPGARMYRTGDRARLLADGRVEFLGRTDDQLKVRGYRVEMGEVEAALERHPSVRESVVVA 5166 Query: 911 EETEA-GPMLAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDR 968 E+ G L Y VP ++++ +R +P+YMVP A V+ +P+T +GK+DR Sbjct: 5167 HESGTDGKRLVGYAVPKPGHTLEVDALRDFLGQTLPDYMVPQALVVLEALPLTPNGKVDR 5226 Query: 969 RALPAP--TPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLV 1026 ALPAP + + P TATE + +F+++ G RVG FF LGGHSLLA + + Sbjct: 5227 NALPAPDFQSVDAEAFVAPRTATEELVAGLFSEVLGLDRVGIHSGFFELGGHSLLATQAI 5286 Query: 1027 AQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGF 1086 ++IR FGV+L +R +F+APT A LA R+ R A P + R G Sbjct: 5287 SRIRGAFGVELPLRDLFEAPTVAALAERVDRWVR----------AGAGFAAPPLKPRAGL 5336 Query: 1087 VKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHE 1146 LPLS +Q WF ++ +N+P ++ GP RHE Sbjct: 5337 TSV-----LPLSFAQQRLWFLEQLAPGSVFYNVPAVVKVSGPLDVAALERSFDALVRRHE 5391 Query: 1147 ALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV-------FTPESGP 1199 +LRT F G P Q++ P V V D D + +R F GP Sbjct: 5392 SLRTTFHADGGTPVQVIAPVGQVVFTVE--DLSGLPDAEQEAQRRADVEALRPFDLAKGP 5449 Query: 1200 LLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFA 1259 LL+ LL LG H+L+L++HHIVSD S+ ++ ++ Y A Q L +Q+ Sbjct: 5450 LLRTMLLRLGEREHLLVLMMHHIVSDGWSMGVLVREVAALYEAFSQGRPSPLPELAVQYP 5509 Query: 1260 DYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR 1319 DYAVWQR + + +L YW+ L G P + + TD+ARP V G + P A Sbjct: 5510 DYAVWQREWLKGEVLEAQLGYWKQRLEGAPAALELPTDKARPAVQTYGGVLRHEVWPKAL 5569 Query: 1320 RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANV 1379 + L R GAT FM+ AA VL K G D+ +G+P+A R + T L+G FAN+ Sbjct: 5570 WRDMEALGRREGATPFMVLLAAYQWVLSKYAGQEDVCVGAPIAGRAQGETEGLIGFFANM 5629 Query: 1380 VVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNF 1439 +VLRT +S T R +L R+ L A AHQ++P E+LVE L P R LSR+PLFQ L Sbjct: 5630 LVLRTKVSPASTFRELLAQVREVTLGAYAHQDVPFEKLVEELQPERDLSRSPLFQVTLTL 5689 Query: 1440 R 1440 + Sbjct: 5690 Q 5690 Score = 655 bits (1689), Expect = 0.0 Identities = 480/1464 (32%), Positives = 697/1464 (47%), Gaps = 83/1464 (5%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 L+ Q+R+WFL P ++ + L+G +DE L + +V RH LRT +G + Sbjct: 34 LTFSQQRVWFLVQRAPGLPAYHLPLVLELSGRLDEAVLERSFQEVARRHESLRTHFG-EV 92 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 G P Q + + E L +PEA E + E PFDL+ R ++R Sbjct: 93 SGTPVQFVDPQARLPFTVEGLEDVPEAAREAAVRQRIQLELETPFDLSRGPLARGVLLRV 152 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSV-- 221 + VLL+VVHH+ D +S V E+ A Y+ P+ L V LQ S Sbjct: 153 APERHVLLVVVHHLISDHESMGVLTHEMVALYDAFAQGQPSP--LPVLPLQYGDYASWQR 210 Query: 222 ---------ADVGYWAETLRXXXXXXXXXGVSGANPC--RRAQRRVRPLPAGLFSRVEDF 270 A + +W + L R AQRR LP R+E Sbjct: 211 GKLRGDALDAHLEFWRKRLEGAPHELELLTDRPRRSATGRAAQRRAL-LPVSWVERLESL 269 Query: 271 ARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFGNTLLLRITT 329 A+ A+ FM +LA VL+ RYTG D L+ T R G +G F +L+LR Sbjct: 270 AQAEGATLFMAVLAGLQVLLSRYTGQKDLLIGASHTNRGRKETKGLVGLFAESLVLRADL 329 Query: 330 RSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAG 389 + + + + FA+ V + ++ E+ V LG Sbjct: 330 SGRPGYRELLRRAKADTEEAFANAHVPFEPLLSALGVEQDPTRAPMFQVLLG-ESDAPPP 388 Query: 390 GLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQL 448 + G+ VR+L + + L+L ++ PD +++ Y +L + ++ +L H L Sbjct: 389 LQEVQGLGVRELDADVSSTDVDLTLMMSRGPDGLALTATYNAELYDATTIEGLLGHLETL 448 Query: 449 VDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXX 508 +D A+ P+RP+++L +L ER +L +G +P Sbjct: 449 LDAAVTSPDRPVATLAMLPVEERHRLLETWNGANEPLPPDACAHALFEAQVARTPDATAV 508 Query: 509 XVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYL 568 VS +TY EL+ RAN +A G G E + + + S+E + A+L VLKAG AY+ Sbjct: 509 -VSGGESVTYRELNARANHVAARLRALGVGLESRVAVCVERSVELLAALLGVLKAGGAYV 567 Query: 569 PIDPAYPDERIDYLITDARPQTVIGRPE-------------LDVAERAAADNSDLPLSDS 615 P+DP YP ER+ Y++ D+ + V+ R E LDVA D S Sbjct: 568 PLDPEYPAERLGYMLEDSGARVVVARREYREKLGEAPGRVWLDVASLTP----DAEGKTS 623 Query: 616 DRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAE---DRWLQFS 672 + + P AYV+YTSGSTGRPKGV V H ++ ++ AEW + DR LQF+ Sbjct: 624 EPTAVVPPEAAAYVLYTSGSTGRPKGVVVQHRSLVSFIR---AEWQVCPVEPGDRVLQFA 680 Query: 673 SVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXX 732 S+S+D S +I+ L G L++ P+ G+T Sbjct: 681 SISWDTSAEEIYPCLTRGGTLVLRTPEMLDVPEVFLARCEAAGITQLNLPTAFWHEVTAS 740 Query: 733 XXXXQWRQ---LRHVPVGGE-ALPGEVAD-RFAGYFDAELRNHYGPTE--AVVCSTHMVV 785 + R L+ V +GGE A+P V+ R L N YG TE AV + + Sbjct: 741 LDEGKARLPSGLKWVVIGGERAVPARVSQWRQRVGHAVPLLNTYGLTEVTAVATAVDLTT 800 Query: 786 TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 R V IG P NV YVLD +L PVP V+GELY+GG +ARGYLGRP LTA+RF Sbjct: 801 DTEDSGREVAIGRPLTNVRIYVLDGELEPVPAGVVGELYVGGEGVARGYLGRPELTAERF 860 Query: 846 IADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRH 905 + P G RLYRTGD R G LE++GR D QVK+RG RIE GEVES + P VR Sbjct: 861 VPAPQGDGARLYRTGDKARWRRDGVLEYLGRGDSQVKVRGHRIEPGEVESALLGQPGVRE 920 Query: 906 CLVVAEETEAGPM-LAAYLVPAAAQVDLE--EIRAHTAAAVPEYMVPGAFAVIPEIPMTV 962 LVV E G L AY+VP ++ LE E+RA + +P +MVP A V+ +P+ Sbjct: 921 VLVVVREDAPGDKRLVAYVVPRDGRL-LEGGEVRAGLESRLPRFMVPQAVVVLERLPLLP 979 Query: 963 SGKLDRRALPAPTPIATRR---YREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHS 1019 +GK+DR+ALPAP + R + P T E+ + +A++ + VG D+FF +GGHS Sbjct: 980 NGKVDRKALPAPEAVRESRKEAHVAPRTPVEQMLAGFWAEVLRLETVGLHDNFFEVGGHS 1039 Query: 1020 LLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDP 1079 LLA +LVA++R F VDL +R +F++ T A LA R+ +A +P P Sbjct: 1040 LLAMQLVARVRESFRVDLPLRDVFESATVAALAERISRA-----------VATAGIPAPP 1088 Query: 1080 KRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXX 1139 + + R PLS +Q WF +++ A +N+ +R G Sbjct: 1089 LK------RMERGGTAPLSFAQQRLWFLAQLDPANTSYNLWAPVRVTGALDVGALARSFE 1142 Query: 1140 XXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAV--RAIDQDEFDDVSTQLRRHV----- 1192 RHEALRT F G P Q++ V L V ++ + + S + R Sbjct: 1143 ALVRRHEALRTTFRAEGGSPVQVISAETQVPLEVVDLSVLPEGEREASAKARTEAEVGRP 1202 Query: 1193 FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWD 1252 F E GPLL+ LL L HVL+L++HHIVSD+ S+ I+ ++ Y A Q Q Sbjct: 1203 FQLEQGPLLRTVLLKLSEQEHVLVLVMHHIVSDYWSMGILVREVAALYEALSQGRPAQLP 1262 Query: 1253 ILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQ 1312 L +Q+AD+A+WQR+ + +++L YWR LAG P + + TD+ RP RG + Sbjct: 1263 ELSVQYADFAMWQRDWLKGQVLESQLAYWRKQLAGAPRALELPTDKPRPATQTFRGANLH 1322 Query: 1313 FSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQL 1372 P A + L R G T FM+ AA VL + G D+++G+P+A R T L Sbjct: 1323 VLWPKALWREVESLGRREGVTPFMVLLAAFQTVLSRYSGQDDVSVGAPIAGRSHSETEGL 1382 Query: 1373 VGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPL 1432 +G F N +VLR+ LS + R++L R+ L A AHQ++ E+LVE L P R LSR+PL Sbjct: 1383 IGFFVNTLVLRSKLSPALSFRALLGQVREVTLGAYAHQDVSFEKLVEELQPERDLSRSPL 1442 Query: 1433 FQNMLNFRGEDWALVP-RDLTGRG 1455 FQ L + A V R +T +G Sbjct: 1443 FQVTLTLQNTPAAEVQLRGITLKG 1466 Score = 506 bits (1302), Expect = e-140 Identities = 358/1049 (34%), Positives = 528/1049 (50%), Gaps = 54/1049 (5%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++PD N+ + RL+G ++ L + + +V RH LRTT+ + Sbjct: 10638 LSFAQQRLWFLAQLEPDSTVYNVPASVRLSGALNVPALKQSFDALVHRHEALRTTFRTEG 10697 Query: 104 EGEPYQVFSDDVEVGWRRE--DLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVI 161 G P QV D G R + DL LP A E + + +A + RPFDL + LR+ ++ Sbjct: 10698 -GSPVQVI--DPRGGARLDIVDLRSLPAAQREEEAQRIAQEASQRPFDLESGPLLRLALL 10754 Query: 162 RTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPA------AQFLSVEVLQN 215 + VL+LV+HHI D S + EL+ Y P+ Q+ V Q Sbjct: 10755 ALSEQDHVLVLVMHHIVSDGWSMGLLVRELTEFYASFSQGQPSHLPELPLQYADYAVWQR 10814 Query: 216 SAAPSV---ADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAG--LFSRVEDF 270 A +GYW + L + + P G L V Sbjct: 10815 EWLQGDVLDAQLGYWKQRLDGAPRLLELPTDRPRPAVQSLEGAYVPFSLGRELSEAVHAL 10874 Query: 271 ARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFGNTLLLRITT 329 AR+ +PFMVLLAA+ ++ RY+G D V P+ R+ A G +G+F NTL+LR Sbjct: 10875 ARREGVTPFMVLLAAFQAVLARYSGQDDVSVGSPIAGRTRAETEGLIGFFVNTLVLRTRL 10934 Query: 330 RSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAG 389 +F + VRE L +AHQ V +++V PER V L F+ AG Sbjct: 10935 EGSPSFRELLARVREVTLGAYAHQDVPFEKLVEALRPERSLSHSPLFQVMLTFDSTPDAG 10994 Query: 390 GLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL-SSVLVDQMLVHYLQL 448 G A G+ ++ + + + LSL D S EY L ++L H L Sbjct: 10995 GDAQAGMGMKHVAVEHRVSRFDLSLGFVEGKDGFSGGLEYSTVLFEPETAARLLAHLKTL 11054 Query: 449 VDKALAEPERPLSSLDILGAGERDSVLAQ----SHGELVEMPATTMVKXXXXXXXXXXXX 504 ++ A+ EP+R + +L +L A E+ +L + G++ E +V+ Sbjct: 11055 LEGAVTEPDRSVFALPLLDADEQRRLLVEWNDTGSGDVAETSIHALVERQAAATPDAVAV 11114 Query: 505 XXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAG 564 V+ E LTY EL +R++RLAR G GPE +GL + + ++A+L +LKAG Sbjct: 11115 -----VAGEEVLTYRELMQRSDRLARKLRTLGVGPEVRVGLCAERNSDLLIAVLGILKAG 11169 Query: 565 AAYLPIDPAYPDERIDYLITDARPQTVIGR-------PELDVAERAAADNSDLPLSDSDR 617 AY+P+DPAYP +R+ ++I D++P+ ++G+ P DVA R A D+++ +++++ Sbjct: 11170 GAYVPLDPAYPSQRLAFMIEDSQPRVLVGQRALLDALPHGDVA-RLALDDANGLVAEAEA 11228 Query: 618 LRPLR--PGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 LR P HLAYV++TSGSTGRPKGVA++H + ++ ++ L +S++ Sbjct: 11229 APVLRSAPDHLAYVLFTSGSTGRPKGVALAHRSAVAFLRWTTRAFSSDELAGVLASTSLN 11288 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FD S+ ++F L G +++ + + L R VT+ Sbjct: 11289 FDLSVFEMFAPLIRGGSVVIA-----SNALELPSLPGARRVTLINTVPSAMAELVRAQTV 11343 Query: 736 XQWRQLRHVPVGGEALPGEVADRFAGYFDAELR--NHYGPTEAVVCSTHMVVTGSHGARV 793 +R V + GE L + + R N YGPTE ST V R Sbjct: 11344 PD--SVRTVNLAGEPLAQSLVESIHQSAPGVQRVLNLYGPTEDTTYST-WTVAPRGATRE 11400 Query: 794 VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-- 851 +G P AYVLD PVP V GELYLGG+ LARGY+ RP LTA+RF+ D F+ Sbjct: 11401 PTVGRPIEGTRAYVLDALGQPVPQGVAGELYLGGAGLARGYVDRPELTAERFVPDAFSPQ 11460 Query: 852 PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA- 910 PG RLYRTGD R G L+++GR D+QVK+RGFRIELGE+E+V+ HP VR +VV Sbjct: 11461 PGARLYRTGDSARWLPDGVLQYLGRIDQQVKVRGFRIELGEIEAVLRRHPDVREAVVVVR 11520 Query: 911 EETEAGPMLAAYLVPAAAQV-DLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRR 969 ++ G L AY+VP + +V D +R +P++MVP V+ +P+T +GK+DR+ Sbjct: 11521 DDGSEGRRLVAYIVPQSDRVPDATALRRFVKEGLPDFMVPSVVMVLASLPLTPNGKVDRK 11580 Query: 970 ALPAP---TPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLV 1026 ALPAP P +TR Y P A E + I+ +L G +G FF LGGHSLLA R+V Sbjct: 11581 ALPAPDALRPESTRAYVAPRDALELQLTRIWEELLGTGPIGIHSDFFELGGHSLLAMRMV 11640 Query: 1027 AQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 + IR G L V ++F A T A LA+RL Sbjct: 11641 SLIRERLGRSLPVVSLFQAGTLAELASRL 11669 Score = 195 bits (495), Expect = 5e-47 Identities = 135/418 (32%), Positives = 201/418 (48%), Gaps = 17/418 (4%) Query: 1088 KSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEA 1147 K RP LPL+ SQ WF + +++PL L G RHE+ Sbjct: 26 KKPRPA-LPLTFSQQRVWFLVQRAPGLPAYHLPLVLELSGRLDEAVLERSFQEVARRHES 84 Query: 1148 LRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV-------FTPESGPL 1200 LRT+F E G P Q V P + V ++ +R+ + F GPL Sbjct: 85 LRTHFGEVSGTPVQFVDPQARLPFTVEGLEDVPEAAREAAVRQRIQLELETPFDLSRGPL 144 Query: 1201 LQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFAD 1260 + LL + P+ HVLL++VHH++SDH S+ ++ +++ Y A Q +LP+Q+ D Sbjct: 145 ARGVLLRVAPERHVLLVVVHHLISDHESMGVLTHEMVALYDAFAQGQPSPLPVLPLQYGD 204 Query: 1261 YAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARR 1320 YA WQR + L++WR L G P E+ + TDR R G+ + + +P + Sbjct: 205 YASWQRGKLRGDALDAHLEFWRKRLEGAPHELELLTDRPRRSATGRAAQ-RRALLPVSWV 263 Query: 1321 AALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVV 1380 L LA+ GAT FM A L V+L + G D+ +G+ R T LVGLFA + Sbjct: 264 ERLESLAQAEGATLFMAVLAGLQVLLSRYTGQKDLLIGASHTNRGRKETKGLVGLFAESL 323 Query: 1381 VLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 VLR DLSG P R +L ++ +A A+ +P E L+ AL + +R P+FQ +L Sbjct: 324 VLRADLSGRPGYRELLRRAKADTEEAFANAHVPFEPLLSALGVEQDPTRAPMFQVLL--- 380 Query: 1441 GEDWALVP-RDLTGRGETTVVPLPVNFEVALLFLAIGMSVTPSGELDVQVIANADLYE 1497 GE A P +++ G G V L + + L + MS P G L + NA+LY+ Sbjct: 381 GESDAPPPLQEVQGLG---VRELDADVSSTDVDLTLMMSRGPDG-LALTATYNAELYD 434 Score = 49.3 bits (116), Expect = 0.005 Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 4/109 (3%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TE+RL ++ E+L + + + ++F LGG S++A + S L + P +FE T+ Sbjct: 6307 TEQRLASIFAEVLNVERVGLEGDFFELGGHSLLATQLVSRVREELQVELPLRDIFESSTV 6366 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQ 1666 +LA +DA+ G E PP T S S P + A+ +L Q Sbjct: 6367 GKLAERIDASRGTAAAEVRAPP---LTRASRSDALPLSFAQQRLWFLDQ 6412 Score = 46.6 bits (109), Expect = 0.030 Identities = 36/114 (31%), Positives = 55/114 (48%), Gaps = 4/114 (3%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TE +L ++ E+L + + DE++F LGG S++A + S A + P VFE T+ Sbjct: 4184 TEEKLASIFAEVLNVERVSVDEDFFELGGHSLLATQLVSRVREAFHVELPLRDVFEAPTV 4243 Query: 1618 AELAAAVDA-ANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS 1670 +LA ++ NG V+ PP E T A L L L+ GS+S Sbjct: 4244 EKLAQRLETEPNGTQVLHVPPPTRVERTGSLPLSFAQQRLWFLDQ--LEPGSSS 4295 Score = 44.3 bits (103), Expect = 0.15 Identities = 32/109 (29%), Positives = 53/109 (48%), Gaps = 5/109 (4%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TE +L ++ E+L + + DE++F LGG S++A + S A + P VFE ++ Sbjct: 9487 TEEKLASIFAEVLNVERVSVDEDFFELGGHSLLATQLVSRVREAFRVELPLRTVFESRSV 9546 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQ 1666 LA +D+A+G PP + S G P + A+ +L Q Sbjct: 9547 ETLARWLDSASGVAAGLRAPPLVR----ASRDGALPLSFAQQRLWFLHQ 9591 Score = 39.3 bits (90), Expect = 4.9 Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 1/64 (1%) Query: 1559 TERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKW-SAQAGALGLPFPPAMVFEHMTI 1617 TE +L ++ E+L + + DE++F LGG S++A + S +L + P VFE T+ Sbjct: 8428 TEEKLASIFAEVLNVERVSVDEDFFELGGHSLLATQLVSRVRESLQVELPLRDVFESPTV 8487 Query: 1618 AELA 1621 +LA Sbjct: 8488 EQLA 8491 >tr|Q0S3K6|Q0S3K6_RHOSR Tax_Id=101510 SubName: Full=Non-ribosomal peptide synthetase; EC=5.1.1.13; EC=6.2.1.3;[Rhodococcus sp.] Length = 11258 Score = 763 bits (1970), Expect = 0.0 Identities = 524/1481 (35%), Positives = 739/1481 (49%), Gaps = 91/1481 (6%) Query: 23 SGLAA------EQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLA 73 SGLAA E +P + P ER LS Q RMWF+ DPD NI +A RL Sbjct: 7083 SGLAARIGTPDENLRPRPVLAPRERSAFVPLSLAQSRMWFINRFDPDSPAYNIPLAVRLT 7142 Query: 74 GLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHE 133 G +D D L +AV DV+ RH LRT Y EG P+QV +V R DLT P A + Sbjct: 7143 GALDVDALQSAVFDVLDRHESLRTIYPDSPEG-PHQVILPADQV---RLDLT--PAAVSD 7196 Query: 134 RQIESLAADEFGRPFDLTNELP-LRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELS 192 ++ + FD+T ++P +R + + VL LVVHH+ D +S F ++ Sbjct: 7197 DELREQLVEMVTAGFDVTADVPPIRTRLFEVGPQDYVLALVVHHVSTDGESTAPFVRDVM 7256 Query: 193 AAYND-----------LPINDPAAQFLSVEVLQNSAAPS---VADVGYWAETLRXXXXXX 238 AY LP+ E+L + P A + +W +TL Sbjct: 7257 VAYASRAAGREPGFAPLPVQYADYAIWQRELLGSEDDPDSLIAAQLAFWKKTLAGVPDLL 7316 Query: 239 XXXGVSGANPCR--RAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGA 296 P + R R + A + + AR+ +AS FM + AA+ VL+ R +G Sbjct: 7317 ELPVDRPRPPVQSLRGSRIDFTIDAEVHRGLAALARRHNASVFMAVHAAFAVLLSRLSGT 7376 Query: 297 SDFLVSVPVTERSGAAAG-ALGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSV 355 D V P+ R +G F NTL LR+ Q TF ++ RE L F+H V Sbjct: 7377 EDISVGTPIAGRGERELDDVVGMFVNTLALRVQVDGQQTFDEILDRAREADLEAFSHADV 7436 Query: 356 GIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLT 415 +R+V NP R V F A L L + V L + A L L Sbjct: 7437 PFERLVEVLNPARSMAHHPIFQVGYSFQNTTKAE-LELPDLTVTPLEVEGDTAQFDLHLI 7495 Query: 416 IALDPD--DVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERD 472 + P+ +S F + L + V + + +++ A+ P + L + G+ ER Sbjct: 7496 LGDSPEGEQMSGVFTFATDLFDAATVKRFADMFRRVLAAAVDSPRTAVGDLPLAGSDERA 7555 Query: 473 SVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWF 532 V++ + +P TT+ V + LTY++ R NRLAR Sbjct: 7556 LVVSGWNDTERALPETTLADMFASAAAENPDVTAL--VFEGESLTYADFSARVNRLARHL 7613 Query: 533 IGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI 592 +G+G GPE ++GL + S+E +V M A+ AG AYLPIDP +P ER Y++ A+P V+ Sbjct: 7614 VGRGVGPETVVGLAIPRSVELLVGMYAIAAAGGAYLPIDPDHPAERTAYVLESAQPVCVL 7673 Query: 593 -------GRPE------LDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRP 639 G P LD + D S PL+D++R+ PLRP + AYVIYTSGSTGRP Sbjct: 7674 ATRAVVGGLPGEVDYLLLDELDLGGIDPS--PLTDAERITPLRPENAAYVIYTSGSTGRP 7731 Query: 640 KGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPD 699 KGVA++H AIA ++ +E+ +TAED L ++ +FD S+ + + L GA+L+V PD Sbjct: 7732 KGVAIAHRAIANQLRWKQSEYPLTAEDSVLLKTAATFDLSVWEFWWALTAGARLVVATPD 7791 Query: 700 AFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRF 759 D SY+A L++ + V+ Q L V GEALP + RF Sbjct: 7792 GHRDPSYLAALVAEQQVSTVHFVPSLLSAFVAVAEPAQLVSLTRVLCIGEALPADTMLRF 7851 Query: 760 AGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQV 819 DAE+ N YGPTEA V TH G VPIG P N YVLD +LHPVP V Sbjct: 7852 RDVSDAEIFNLYGPTEAAVSVTHYRC-GDERDGSVPIGRPEWNTQTYVLDARLHPVPAGV 7910 Query: 820 IGELYLGGSQLARGYLGRPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEFVGRAD 878 GELYL G QLARGY GR LTA+RF+A+PF + G R+YRTGDLVR N G L++VGR+D Sbjct: 7911 TGELYLAGEQLARGYFGRHDLTAERFVANPFGDAGHRMYRTGDLVRWNRDGNLDYVGRSD 7970 Query: 879 EQVKIRGFRIELGEVESVITTHPAVRHCLVVAE-ETEAGPMLAAYLVPA-AAQVDLEEIR 936 QVK+RGFRIELGE+E + HP+V +VV + G L Y+VP VD ++ Sbjct: 7971 FQVKVRGFRIELGEIERALVAHPSVAQAVVVVHHDRHTGDRLVGYVVPEQGVSVDDADVL 8030 Query: 937 AHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPT-PIATRRYREPETATERWICS 995 +VP YMVP A + +P+ ++GKLDR+ALP P A Y+ P T E + Sbjct: 8031 TFAGRSVPGYMVPSALIALDVLPLNINGKLDRKALPEPEFGGAVDHYKAPRTPVEEIVAG 8090 Query: 996 IFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARL 1055 +FA + G +RV + SFF LGG+SL+A R+VA++ A + VR +F+APT L+AR Sbjct: 8091 VFADVLGHERVSVDTSFFDLGGNSLVATRVVARVNAALDTSIGVRELFEAPTVIALSARA 8150 Query: 1056 VERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGARE 1115 + D+ A+ RP V RP R+PLS +Q WF + + A Sbjct: 8151 EQS---------DSAGAN---------RPALVPQPRPARIPLSPAQSRMWFINQFDTASA 8192 Query: 1116 EFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRA 1175 +N+PLA+R G RHE LRT + + P Q+V SRT + Sbjct: 8193 AYNIPLAIRLTGHLDVSALEQALGDVVERHETLRTTYPDTGDGPGQVVL-SRTRSFT--S 8249 Query: 1176 IDQDEFDDVSTQLRRHVFTPESG------PLLQANLLVLGPDTHVLLLIVHHIVSDHASL 1229 +D + D + R + +G ++A LL + + HVL+++VHHI SD AS Sbjct: 8250 LDVENVADENALRERVISLVTAGFDVAKTVPVRARLLRIDAEQHVLVIVVHHISSDGAST 8309 Query: 1230 EIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDA 1284 + D+++AY AR + P W L +Q+AD+++WQ + ++DYWR Sbjct: 8310 APLARDVVIAYSARAAGSEPAWAPLDVQYADFSLWQHELLGDENASDSLATKQIDYWRTT 8369 Query: 1285 LAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAV 1344 L+GLPD + + TDR RP RG F + A R L LA + A+ FM+ AAL+V Sbjct: 8370 LSGLPDVLPLPTDRPRPPAQSMRGANFDFEIDAELRDRLGALAREHNASLFMVAHAALSV 8429 Query: 1345 VLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVL 1404 +L +L DIA+G+ + R E A LVG+F N +VLR + D T +L R L Sbjct: 8430 LLARLSATDDIAVGTAIEGRGEAALDDLVGMFVNTLVLRAQVDVDKTFADLLAQVRQHDL 8489 Query: 1405 DALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWA 1445 A H ++P ERLVE L P R+ + +PLFQ L F+ + A Sbjct: 8490 GAFTHTDVPFERLVEILQPERSTAFSPLFQVALAFQNIEQA 8530 Score = 674 bits (1738), Expect = 0.0 Identities = 485/1504 (32%), Positives = 730/1504 (48%), Gaps = 110/1504 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS Q+RMWF+ DP N+ +A RL G +D L+ A DVV RH LRT + Sbjct: 6051 DRIPLSLAQQRMWFINQFDPSSPAYNLPLAVRLTGSIDTAALNAAWADVVERHESLRTVF 6110 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 V E + +Q+ +V DLT P A E+ + + + FD+T +P+R+ Sbjct: 6111 PVGDE-DAHQIVLPAADVV---SDLTPTPVAD-EQDLYARMRELGATGFDVTETVPVRVA 6165 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQFL 208 + +L++VVHHI D S F ++ AY LP+ Sbjct: 6166 CFEVNPTDHILMMVVHHISADGASLAPLFTDIMTAYAARAAGTAPGWEPLPVQYADYALW 6225 Query: 209 SVEVLQNSAAPS---VADVGYWAETLRXXXXXXXXXGVSGANPCR--RAQRRVRPLPAGL 263 E L + + P +GYW + L P + R + A Sbjct: 6226 QRESLGDESDPESLVARQLGYWQQALGGLPEVLELPADRPRPPVQSLRGASARFTIDAQT 6285 Query: 264 FSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNT 322 + AR+ +++ FMV+ AA VL+ R + +D + PV R L G F NT Sbjct: 6286 HRGLLTIARETNSTLFMVVHAALVVLLERLSSQTDVAIGTPVAGRGEQELDRLVGMFVNT 6345 Query: 323 LLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGF 382 L+LR + R DTF + +VR T L F+H V +R+V + R V L F Sbjct: 6346 LVLRASVRPDDTFADLLAQVRATDLNAFSHSDVPFERLVEVLDVPRSTAHQPLFQVALSF 6405 Query: 383 NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD-----VSVEFEYQQQLSSVL 437 + +S + G+ + L A L L++ D ++ F Y + + Sbjct: 6406 DNNESVR-MEFPGLEISALDAPLEVAKFDLQLSVGERYVDGAAAGIAATFNYS---TDIF 6461 Query: 438 VDQMLVHYLQLVDKAL----AEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKX 493 +Q ++ + + L A+ + L ++IL A E+ ++ + +E P T Sbjct: 6462 DEQTVLSFADRFGRILHAVSADRDVVLGDIEILDAAEKAAIAPVRGPQSIE-PRTL---- 6516 Query: 494 XXXXXXXXXXXXXXXXVSDEA-ELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIE 552 VS E E TY EL +N+LAR I +G GPE + L + S+E Sbjct: 6517 PELLRSGVEISPESVAVSYEGREATYRELDELSNQLARVLIDRGVGPESYVALAITRSVE 6576 Query: 553 FIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDAR--------------PQTVIGRPELD 598 I+ + ++ KAG AYLP+DP P ERI +++D+ P TV P + Sbjct: 6577 SILGIWSIAKAGGAYLPVDPKLPFERIGEMLSDSGAVLGLTVARHHDDLPGTV---PWIV 6633 Query: 599 VAERAAADN----SDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQ 654 + E AAA+ S + D+D R L H AY+IYTSGSTG+PKGV V+H +A + Sbjct: 6634 LDETAAAEEIGARSAGAVEDADLRRALTVDHPAYLIYTSGSTGKPKGVVVTHRGLANLTR 6693 Query: 655 GFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRR 714 + ++ + R+L +S SFD S+ ++ GA L++ D +G +ADLI R Sbjct: 6694 EVREHYVVSPDSRFLHVASPSFDTSVGEMLAAFSAGATLVISPADVYGG-DELADLIRRE 6752 Query: 715 GVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPT 774 V + V VGG+ E+ R+A E+RN YGPT Sbjct: 6753 RVNNVVMTPTALMTVDPDGLDT----VTSVVVGGDTCTPELVARWAP--GREMRNAYGPT 6806 Query: 775 EA--VVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLAR 832 E +V T +V G V IG P R V + +LD +L PVP+ V GELY+ G + R Sbjct: 6807 ETTVIVTITEPMVAGER----VTIGSPLRGVESLILDSRLRPVPEGVPGELYICGPSVTR 6862 Query: 833 GYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELG 891 GY RP++TA+RF+A+PF PG R+YRTGD+VR +E+VGR+D QVK+RGFR+ELG Sbjct: 6863 GYHNRPSVTAERFVANPFGEPGARMYRTGDVVRWADGHRVEYVGRSDFQVKVRGFRVELG 6922 Query: 892 EVESVITTHPAVRHCLVVAEETEAG-PMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVP 949 E+++ + P V + V E AG L +Y++PA A VD E +++ +P YMVP Sbjct: 6923 EIDAALAAQPNVEFAVTVGRENPAGLTTLVSYVLPADGATVDPESLKSVVGETLPPYMVP 6982 Query: 950 GAFAVIPEIPMTVSGKLDRRALPAPTPI-ATRRYREPETATERWICSIFAQLFGRQRVGA 1008 ++ E+P+T GKLDR LP P + A +R P T E I IFA + G ++V Sbjct: 6983 SVVILLDEVPLTGIGKLDRARLPEPEFVTAGAEFRAPTTPAEETIAGIFADVLGLEQVSV 7042 Query: 1009 EDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLD 1068 +D FF LGG+SL A R+V++ FG + VR +F+APT +GLAAR+ Sbjct: 7043 DDRFFDLGGNSLSATRVVSRAGQVFGRRIGVRELFEAPTVSGLAARI------------- 7089 Query: 1069 NLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGP 1128 P + R RP R +PLS +Q WF R + +N+PLA+R G Sbjct: 7090 -----GTPDENLRPRPVLAPRERSAFVPLSLAQSRMWFINRFDPDSPAYNIPLAVRLTGA 7144 Query: 1129 XXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVR--AIDQDEFDDVST 1186 RHE+LRT + + P+Q++ P+ V+L + A+ DE + Sbjct: 7145 LDVDALQSAVFDVLDRHESLRTIYPDSPEGPHQVILPADQVRLDLTPAAVSDDELREQLV 7204 Query: 1187 QLRRHVFTPESG-PLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQ 1245 ++ F + P ++ L +GP +VL L+VHH+ +D S D++VAY +R Sbjct: 7205 EMVTAGFDVTADVPPIRTRLFEVGPQDYVLALVVHHVSTDGESTAPFVRDVMVAYASRAA 7264 Query: 1246 HNAPQWDILPIQFADYAVWQRNTFESNWGQ-----TELDYWRDALAGLPDEISVATDRAR 1300 P + LP+Q+ADYA+WQR S +L +W+ LAG+PD + + DR R Sbjct: 7265 GREPGFAPLPVQYADYAIWQRELLGSEDDPDSLIAAQLAFWKKTLAGVPDLLELPVDRPR 7324 Query: 1301 PRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSP 1360 P V RG + F++ A L LA R+ A+ FM AA AV+L +L G DI++G+P Sbjct: 7325 PPVQSLRGSRIDFTIDAEVHRGLAALARRHNASVFMAVHAAFAVLLSRLSGTEDISVGTP 7384 Query: 1361 VAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEA 1420 +A R E +VG+F N + LR + G T IL +R+ L+A +H ++P ERLVE Sbjct: 7385 IAGRGERELDDVVGMFVNTLALRVQVDGQQTFDEILDRAREADLEAFSHADVPFERLVEV 7444 Query: 1421 LNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSVT 1480 LNP R+++ +P+FQ +F+ A + + TV PL V + A L + + + Sbjct: 7445 LNPARSMAHHPIFQVGYSFQNTTKAELELP-----DLTVTPLEVEGDTAQFDLHLILGDS 7499 Query: 1481 PSGE 1484 P GE Sbjct: 7500 PEGE 7503 Score = 668 bits (1724), Expect = 0.0 Identities = 492/1479 (33%), Positives = 727/1479 (49%), Gaps = 109/1479 (7%) Query: 27 AEQSSDQPGICPGERYR---LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHT 83 A S +P + GER R LS Q+RMWFL DP N+ + RL G +D L Sbjct: 3784 AHHGSTRPALVAGERPRELPLSLAQQRMWFLNRFDPSSPAYNVPLTVRLRGELDVAALAA 3843 Query: 84 AVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADE 143 A++DVVARH +LRT + D++ +QV ++ E + EA +R E Sbjct: 3844 ALSDVVARHEVLRTVFP-DSDSGAHQVILPPADIDLALEPVDVREEALRDRMFE------ 3896 Query: 144 FGRP-FDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-DLPIN 201 FG FD+T+ +P+R + R A + VL+LV+HHI D S ++ AY +L Sbjct: 3897 FGSTGFDVTDTIPVRARLFRLGAADHVLVLVMHHIASDGASTLPLARDVMTAYAANLDGT 3956 Query: 202 DPAAQFLSVE----------VLQNSAAP---SVADVGYWAETLRXXXXXXXXXGVSGANP 248 PA L V+ VL + P + A + +W++TL A P Sbjct: 3957 QPAWPVLPVQYGDYALWQRDVLGSEDDPDSLAAAQIDFWSKTLAGVPDVL-------ALP 4009 Query: 249 CRRAQRRVRPLPAG---------LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDF 299 R + VR + + R+ + AR + S FMVL A+ VL+ R + ++D Sbjct: 4010 IDRPRPTVRSMAGASVGFSVDEDIHRRLGEVARAHNVSLFMVLHASLSVLLARLSASTDI 4069 Query: 300 LVSVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGID 358 + V R A L G F NTL+LR +F + +VR LA F++Q V + Sbjct: 4070 AIGTAVAGRGDEALENLVGMFVNTLVLRTEVEPGTSFAELLEQVRTQDLAAFSNQDVPFE 4129 Query: 359 RVVREANPERMGRDGMDLLVRL-----GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLS 413 ++V P R V L G + AG A G V + + L Sbjct: 4130 QLVDVLKPTRSTAYSPLFQVVLTHQVNGIPSLEFAGLEATPGAVDVEFSKFDLTVDLREL 4189 Query: 414 LTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVDKALAEPERPLSSLDI-LGAGERD 472 + P ++ + ++ Q + A+A ++ DI + E Sbjct: 4190 WSDEGAPTGITGVLGFATEIFDAETVQGFADRFVRILAAVAGGGTDIAVGDIPILDAEET 4249 Query: 473 SVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWF 532 + L G + P TT+V+ VS +TY EL +NR+AR Sbjct: 4250 AELTPVRG-IEGTPPTTLVELLSAAVAANPDGVAI--VSGGDSITYRELDELSNRVARIL 4306 Query: 533 IGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDA------ 586 I +G G E +GL + SI I + AV K+G AY+PIDP YPDERI +++TD+ Sbjct: 4307 IERGVGAETFVGLGITRSIVSIAGIWAVAKSGGAYVPIDPGYPDERIAHMVTDSGVSLGL 4366 Query: 587 RPQTVIGRPELDVA---------ERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTG 637 + +GR DV E AAA S P+++ +R + P + AYVIYTSG+TG Sbjct: 4367 SVSSEVGRLPADVDWLVLDSEDFENAAAQYSTAPVAEVERRTAVTPANSAYVIYTSGTTG 4426 Query: 638 RPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPK 697 +PKGV V+H +A + +T + R L F+S SFDAS+ ++ + + GA +++ Sbjct: 4427 QPKGVVVTHRGLANFAAEQRERYRVTTDSRTLHFASPSFDASVLELLLAVGAGATMVIAP 4486 Query: 698 PDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVAD 757 D +G + L R Q+ V GGEA+P E+A Sbjct: 4487 TDVYGGPEFAKFLREHRVTHGFVTPSALASVDPSGLDDFQF-----VVAGGEAVPAELAA 4541 Query: 758 RFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPD 817 R+A L N YGPTE + + + G V IG P R A VLD++L PVP Sbjct: 4542 RWAP--GRSLFNGYGPTETTIMTNISDPMAADGP--VTIGGPIRGTSALVLDDRLRPVPV 4597 Query: 818 QVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGE----LE 872 + G+LYL G LARGY R LTA RF+A+P+ PG R+YRTGD+VR + ++ Sbjct: 4598 GIAGDLYLSGLGLARGYHRRTPLTAGRFVANPYGEPGDRMYRTGDVVRWTKDADGALTVD 4657 Query: 873 FVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGP-MLAAYLVPA-AAQV 930 +VGR+D+QVK+RGFRIELGE+++V+ HPAV +G +L +Y++P +V Sbjct: 4658 YVGRSDQQVKVRGFRIELGEIDAVLAKHPAVDFATTSVLPGPSGDSVLVSYVLPVPGVEV 4717 Query: 931 DLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIAT-RRYREPETAT 989 D+ + VP YMVP + IP+T GKLDRRALP P +A R +R TA Sbjct: 4718 DVPRMLDFVGEFVPTYMVPSTIVTLDAIPLTPVGKLDRRALPEPEFLAEDREFRAAGTAL 4777 Query: 990 ERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPA 1049 E+ + ++FA++ G VGA+DSFF LGG+SL A R++A+I G+D VR IF+APT A Sbjct: 4778 EQRVAAVFAEVLGVDVVGADDSFFTLGGNSLAATRVMARINEAVGIDAPVREIFEAPTVA 4837 Query: 1050 GLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYR 1109 LA RL E L +D ARP RP RLPLS +Q W+ R Sbjct: 4838 QLARRLEE-------LGVDG-----------GARPPVTAGPRPDRLPLSLAQQRMWYANR 4879 Query: 1110 IEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV 1169 + E+N+PLALR G RHE+LRT + + PYQ+V P+ Sbjct: 4880 FDPESAEYNIPLALRLTGALDVDALRSAIADVVARHESLRTVYPDSVDGPYQVVLPASDT 4939 Query: 1170 QLA---VRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDH 1226 + VR D+ E + L F + ++A L LG HVL+++VHHI +D Sbjct: 4940 KSGLDVVRVADEQELRERVVALASAGFDVTADVPVRAALFELGERDHVLVVVVHHISADG 4999 Query: 1227 ASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFES-----NWGQTELDYW 1281 +S+ + DL AY AR+Q P + LP+Q+ D+A+WQRN S + ++ YW Sbjct: 5000 SSMAPLARDLFGAYGARVQGEEPGFSPLPVQYPDFALWQRNLLGSEDDPDSLAGKQIAYW 5059 Query: 1282 RDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAA 1341 AL P+ + + DR RP V +G +++F + +L LA+ + A+ FM+ A Sbjct: 5060 THALGDAPEVLDLPADRPRPAVRNPQGGLIEFEIGQDVHRSLNDLAQTHQASLFMVVHTA 5119 Query: 1342 LAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRD 1401 LAV+L +L +DI++ +PVA R + A LVG+F N +VLRTD+ + ++L +R+ Sbjct: 5120 LAVLLGRLSNTSDISVSTPVAGRGDRALDDLVGMFVNTLVLRTDVDQNARFSTLLTQARE 5179 Query: 1402 TVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 L+A + ++P E++VE L P R + PL Q ML+F+ Sbjct: 5180 VDLNAFGNADVPFEQIVEVLRPSRTAAYAPLAQVMLSFQ 5218 Score = 629 bits (1622), Expect = e-177 Identities = 463/1457 (31%), Positives = 709/1457 (48%), Gaps = 90/1457 (6%) Query: 31 SDQPGICPGERYRLSDGQRRMWF---LQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVND 87 SD P + G+ + L+ Q + F L D D T + + L G VD DRL A Sbjct: 1546 SDYPAL--GDVWSLAPLQVGLLFHASLAGTDTDVYTTQLVMD--LGGSVDTDRLRRAAES 1601 Query: 88 VVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRP 147 +VARH LRT + +G QV D V+V W DL+ E+ ++E+L Sbjct: 1602 LVARHPNLRTAFVAGDDGAGMQVVVDRVDVPWTHVDLSAASESDRAAELEALMLANRTDR 1661 Query: 148 FDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY----NDLPINDP 203 FD+T +R ++ T D + HHI D S + +L Y ++L + P Sbjct: 1662 FDMTAPPLVRFLLVETGEDRYRFAVTNHHILLDGWSLPILIQDLLTLYAVDGDELALPQP 1721 Query: 204 AAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGAN-PCRRAQRRVRPLPAG 262 +E L SA V W + L P V LP Sbjct: 1722 RPYRSYLEWL--SAQDPQVPVAAWTKALGGIEEPTLLAPAHAETAPTLTPGELVIDLPDD 1779 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA---LGYF 319 L + + +R+ + ++ AA+G+++ R TG D + V+ R G LG F Sbjct: 1780 LLADMTARSRELGVTMNTLVQAAWGIVLGRLTGRDDVVFGTTVSGRPPQVPGIESMLGLF 1839 Query: 320 GNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVR 379 NTL +R+ R+ D + ++ ++ H VG+ + + +G L+V Sbjct: 1840 INTLPVRVRVRAGDAVRTLLDRIQHEQTELLDHHHVGLTDIQQGLG---LGALFDTLMVY 1896 Query: 380 LGFNMRKSAGGLALDGVVVRQLGLGAV-AAHLPLSLTIALDPDDVSVEFEYQQQLSSVLV 438 + + + A + D +R L + + A H PL++ DP + + V Sbjct: 1897 ESYPLDREALTKSSDIEGLRVLDVTSNDATHYPLAIVAMTDPRLHLTAKFLPEIFEAAEV 1956 Query: 439 DQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXX 498 ++++ ++++ + + ++ +DIL GER S+LA +HG +P + Sbjct: 1957 EEIMERVVRVLGALSGDVDTLVADIDILAPGERASLLA-AHGTDAVVPLSL---PEILAA 2012 Query: 499 XXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAML 558 V+D LTY+EL R+N LAR + +G GPE + L M S+ ++A Sbjct: 2013 TAAENGERTALVADGESLTYAELDARSNLLARVLVDRGVGPETSVALGMTRSLHSVIATW 2072 Query: 559 AVLKAGAAYLPIDPAYPDERIDYLITD----------ARPQTVIGRPE---LDVAERAA- 604 AV KAG ++P+DP YP ERI +++ D A+ T+ E LD +E A Sbjct: 2073 AVAKAGGTFVPVDPRYPSERIAHMVADSGAILGLTVAAQRDTLPSDVEWLALDSSECDAL 2132 Query: 605 -ADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMT 663 A S P++DS+R ++ H AY+IYTSG+TG PKGV V+H +A + ++ Sbjct: 2133 CAPKSADPVTDSERTASVQLEHPAYMIYTSGTTGLPKGVVVTHTGLANFSAEQRTHYGVS 2192 Query: 664 AEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXX 723 R L F+S SFDAS+ ++ + GA +IV D +G + + ++ VT Sbjct: 2193 PSARTLHFASPSFDASVLELLLAFGCGATMIVAPADLYGG-EELRNFLADNEVTHAFVTP 2251 Query: 724 XXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCS--T 781 +L V VGGEA P E+ +R+A + N YGPTEA + S + Sbjct: 2252 AALASVEPAGLD----RLEVVVVGGEACPPELVERWAP--GRRMYNGYGPTEATIMSNVS 2305 Query: 782 HMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLT 841 +++V GS V IG P V YVLDE L PVP V GELY+ G LARGY R LT Sbjct: 2306 NLLVPGSR----VEIGGPVCGVTVYVLDELLRPVPVGVAGELYIAGPGLARGYHDRLGLT 2361 Query: 842 AQRFIADPF-NPGMRLYRTGDLVR-------RNHCGELEFVGRADEQVKIRGFRIELGEV 893 A+RF+A+PF + G R+YRTGD+VR R+ G +E+VGR+D QVK+RGFRIELGE+ Sbjct: 2362 AERFVANPFGDSGSRMYRTGDVVRFVVDHGHRSGYG-VEYVGRSDFQVKVRGFRIELGEI 2420 Query: 894 ESVITTHPAVRHCLVVAEETEAGPM-LAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGA 951 ++V+ HP + + +G L +Y++P A A VD+ E+ +P +MVP + Sbjct: 2421 DAVLVKHPDLEFAATLGTSMPSGSTALVSYVLPTAGASVDVAEVTHFVGDMLPAHMVPSS 2480 Query: 952 FAVIPEIPMTVSGKLDRRALPAPTPIATR-RYREPETATERWICSIFAQLFGRQRVGAED 1010 V+ EIP+T +GKLDR+ALP P A + EP T TE + + A + G ++ + Sbjct: 2481 VVVLDEIPLTTAGKLDRKALPEPDFDALQGEMIEPRTPTEELVAGVLADVLGLAKISVAE 2540 Query: 1011 SFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNL 1070 SFF LGG+SL+A + VA++ A G L VR +FDAPT LA ++ E+ + Sbjct: 2541 SFFDLGGNSLVATKAVARLNAAAGTRLGVRELFDAPTVERLAVKVAEQAGTGSD------ 2594 Query: 1071 AADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXX 1130 RP V RP+R+PLS +Q + W R + A +N+PLA+R G Sbjct: 2595 ------------RPVLVARPRPERVPLSMAQQSMWLMNRFDTASSAYNIPLAVRLSGSLD 2642 Query: 1131 XXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTV--QLAVRAIDQDEFDDVSTQL 1188 RHE+LRT F + PYQ + + V L + + E T+ Sbjct: 2643 IDAMSSAVSDVLARHESLRTVFPDAGDGPYQQIVDTEQVPFDLTPVPVTEAELHTALTEF 2702 Query: 1189 RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNA 1248 F P L+ L +L+L+VHHI +D AS+ + D++VAY AR A Sbjct: 2703 ATEGFDVTVAPPLRIRLFATSESEFLLVLVVHHICADGASMSPLARDVMVAYSARTAGAA 2762 Query: 1249 PQWDILPIQFADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRV 1303 P W LP+Q+ D+A+WQR + ++ +W D LAG P+ I + D ARP Sbjct: 2763 PLWQPLPVQYPDFALWQREVLGDPADTQSLAGKQIAHWADTLAGAPELIDLPLDHARPAR 2822 Query: 1304 LGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAA 1363 RG+ + F++ R L + + GA+ FM+ AAL +L +L DI +G+P+AA Sbjct: 2823 QSMRGDSIDFAITPELRRGLEAVGKERGASLFMVTHAALTTLLSRLSNSDDITVGTPLAA 2882 Query: 1364 RVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNP 1423 R + A LVG+F N +VLRT + + ++ R+ L A + ++P E++VEAL Sbjct: 2883 RSDQALDDLVGMFVNTLVLRTHVRPGDSFAELVERVREGDLAAFGNSDVPFEKIVEALRI 2942 Query: 1424 PRALSRNPLFQNMLNFR 1440 R+ + +PLFQ ML+F+ Sbjct: 2943 RRSAAYSPLFQVMLSFQ 2959 Score = 581 bits (1498), Expect = e-163 Identities = 362/967 (37%), Positives = 522/967 (53%), Gaps = 68/967 (7%) Query: 516 LTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYP 575 LTYSEL RAN+LAR I +G GP+ ++ + + S + +V++LAV+KAG YLP D YP Sbjct: 5464 LTYSELDVRANKLARLLISRGVGPDSLVAVALDRSADLVVSLLAVVKAGGGYLPTDVTYP 5523 Query: 576 DERIDYLITDARPQTVI-------GRPELDV------AERAAADNSDL---PLSDSDRLR 619 +R+++++TDARP ++ G P+ + A+ D +DL P+ + +R Sbjct: 5524 ADRLEFMLTDARPVVILTSIAHAAGLPDTGIPTVLLDADETLIDLADLDAGPVEERERHA 5583 Query: 620 PLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDAS 679 LR +LAYVIYTSGSTGRPKGV V+H A+ + E+ D W F S +FD S Sbjct: 5584 ALRANNLAYVIYTSGSTGRPKGVMVTHSAVVQLFDRTFGEFGFDDSDVWTLFHSYAFDFS 5643 Query: 680 LADIFVTLFLGAQLIVP------KPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXX 733 + +++ L G +L+V PD F L+SR VTV Sbjct: 5644 VWELWGALLYGGRLVVVDYLTSRSPDEF------RALLSRERVTVLSQTPSAFYQLSAAD 5697 Query: 734 XXXQWRQ---LRHVPVGGEALP-GEVADRFAGYFDAELR--NHYGPTEAVVCSTHMVVTG 787 + LR+V GGEAL G+++ + + + R N YG TE V TH+ + Sbjct: 5698 RALETPDDLALRYVIFGGEALDLGQLSKWYDRHPETAPRLVNMYGITETTVHVTHLALDR 5757 Query: 788 --SHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 + A +G P + +VLD +L PVP V GE+Y+ G QL RGYL RP LT+ RF Sbjct: 5758 KFAESASASVVGEPIDGLRVHVLDSRLRPVPTGVSGEMYISGGQLTRGYLQRPDLTSTRF 5817 Query: 846 IADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVR 904 +A+PF G RLYR+GD+ R N G LE++GR+D Q+++RGFRIELGE+ES + P V Sbjct: 5818 VANPFGATGGRLYRSGDVARWNSAGLLEYLGRSDSQIQLRGFRIELGEIESALLRAPGVA 5877 Query: 905 HCL-VVAEETEAGPMLAAYLVPAAAQVDLE-EIRAHTAAAVPEYMVPGAFAVIPEIPMTV 962 + VV + E G L Y+VP + + + EI+ + + YMVP V+ +P+TV Sbjct: 5878 ASVAVVLRDAEVGDRLVGYVVPESGAILVPTEIKDFASGFLTSYMVPDVVMVLGAMPITV 5937 Query: 963 SGKLDRRALPAPT-PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLL 1021 +GKLDR+ALPAP + + P T E + +FA++ G +RVG DSFF LGG+S+ Sbjct: 5938 NGKLDRKALPAPEITVLQSEFVAPSTPVEEIVAGVFAEVLGVERVGTADSFFDLGGNSIS 5997 Query: 1022 AARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKR 1081 A RL A++ A G L+VR F+ PT A LAA L + Sbjct: 5998 ATRLTARLTAALGAQLSVRECFEHPTVAELAALL------------------EATAGTAE 6039 Query: 1082 ARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXX 1141 RP V ARP R+PLS +Q WF + + + +N+PLA+R G Sbjct: 6040 HRPTLVARARPDRIPLSLAQQRMWFINQFDPSSPAYNLPLAVRLTGSIDTAALNAAWADV 6099 Query: 1142 XXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFT----PES 1197 RHE+LRT F + +QIV P+ V + + D+ ++R T E+ Sbjct: 6100 VERHESLRTVFPVGDEDAHQIVLPAADVVSDLTPTPVADEQDLYARMRELGATGFDVTET 6159 Query: 1198 GPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQ 1257 P+ A V P H+L+++VHHI +D ASL +F D++ AY AR AP W+ LP+Q Sbjct: 6160 VPVRVACFEV-NPTDHILMMVVHHISADGASLAPLFTDIMTAYAARAAGTAPGWEPLPVQ 6218 Query: 1258 FADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQ 1312 +ADYA+WQR + + +L YW+ AL GLP+ + + DR RP V RG + Sbjct: 6219 YADYALWQRESLGDESDPESLVARQLGYWQQALGGLPEVLELPADRPRPPVQSLRGASAR 6278 Query: 1313 FSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQL 1372 F++ A L +A +T FM+ AAL V+L +L TD+A+G+PVA R E +L Sbjct: 6279 FTIDAQTHRGLLTIARETNSTLFMVVHAALVVLLERLSSQTDVAIGTPVAGRGEQELDRL 6338 Query: 1373 VGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPL 1432 VG+F N +VLR + D T +L R T L+A +H ++P ERLVE L+ PR+ + PL Sbjct: 6339 VGMFVNTLVLRASVRPDDTFADLLAQVRATDLNAFSHSDVPFERLVEVLDVPRSTAHQPL 6398 Query: 1433 FQNMLNF 1439 FQ L+F Sbjct: 6399 FQVALSF 6405 Score = 506 bits (1302), Expect = e-140 Identities = 340/960 (35%), Positives = 490/960 (51%), Gaps = 65/960 (6%) Query: 517 TYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPD 576 T EL+RRAN+LAR QG GP+D++ L + S+E+++ M+A K GAAY P D + Sbjct: 3218 TRGELNRRANQLARELRAQGVGPDDVVALIVPRSLEWVIGMIAAWKLGAAYSPFDQDWGL 3277 Query: 577 ERIDYLITDARPQTVI-------------GRPELDVA---------ERAAA-DNSDL--- 610 +RI LI D+ + V+ G LD A ER AA D SD Sbjct: 3278 DRIVGLIEDSGTRAVVVTNSWSGLTEAPLGNAVLDAAIVVDDADTIERLAAHDVSDFAHD 3337 Query: 611 PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQ 670 P SD++ LAYVI TSGSTGRPK V ++ Q + T L Sbjct: 3338 PWSDAEA-----SSRLAYVISTSGSTGRPKPTMVPMIGVSNTYQWYRHALDFTEGTGVLV 3392 Query: 671 FSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXX 730 +S FD + +I+V++ G + + +P D + I V + Sbjct: 3393 ANSPLFDQTQKNIWVSVAYGGVMHLAQPGF--DPLPILRQIGTGDVQIANMAPSAFEVLS 3450 Query: 731 XXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVC-STHMVVTGSH 789 +L V VGGE L G L N YGPTEA S++ V S Sbjct: 3451 DLDTEGVLGKLDIVVVGGEQLRPAACSALIGT-QTRLINTYGPTEASATDSSYEVDLSSA 3509 Query: 790 GARV--VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIA 847 A VP G V +VLD ++ PVP V GELY+GG LARGY G +TA RF+A Sbjct: 3510 DAEQWPVPFGAAFEGVEYHVLDGRMRPVPPGVTGELYIGGIVLARGYGGMTGITASRFVA 3569 Query: 848 DPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHC 906 +PF N G RLYRTGDLVR G+L FVGR+D QVKIRG RIELGE+ES +T + V Sbjct: 3570 NPFGNAGTRLYRTGDLVRERDHGQLVFVGRSDFQVKIRGLRIELGEIESALTANSDVLQS 3629 Query: 907 LVVAEETEAGPMLAAYLVPAAA-QVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGK 965 +VV E+E GP L +Y+ AA ++D++ I A+P +M+P V+ E+P+ + K Sbjct: 3630 VVVVHESEQGPRLVSYVTAAAGVELDIDAILDDLHRALPSHMIPDTVMVLDEMPLNANLK 3689 Query: 966 LDRRALPAPT-PIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAAR 1024 +DR+ALP P +T + P T E + IF + RV ++SFF LGG+SL A R Sbjct: 3690 VDRKALPEPVFATSTVEFVAPRTPLEEVVAGIFGDVVSATRVSVDESFFDLGGNSLSATR 3749 Query: 1025 LVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARP 1084 + A++ + G ++ +R +F+APT A LA + +R + RP Sbjct: 3750 VAARVTSATGTEVGIRDLFEAPTVATLAKLVEDRAHHG------------------STRP 3791 Query: 1085 GFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXR 1144 V RP+ LPLS +Q WF R + + +N+PL +R G R Sbjct: 3792 ALVAGERPRELPLSLAQQRMWFLNRFDPSSPAYNVPLTVRLRGELDVAALAAALSDVVAR 3851 Query: 1145 HEALRTNFDEHEGVPYQIVHPSRTVQLAVRAID--QDEFDDVSTQLRRHVFTPESGPLLQ 1202 HE LRT F + + +Q++ P + LA+ +D ++ D + F ++ Sbjct: 3852 HEVLRTVFPDSDSGAHQVILPPADIDLALEPVDVREEALRDRMFEFGSTGFDVTDTIPVR 3911 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYA 1262 A L LG HVL+L++HHI SD AS + D++ AY A L P W +LP+Q+ DYA Sbjct: 3912 ARLFRLGAADHVLVLVMHHIASDGASTLPLARDVMTAYAANLDGTQPAWPVLPVQYGDYA 3971 Query: 1263 VWQRNTFES-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPA 1317 +WQR+ S + ++D+W LAG+PD +++ DR RP V G V FSV Sbjct: 3972 LWQRDVLGSEDDPDSLAAAQIDFWSKTLAGVPDVLALPIDRPRPTVRSMAGASVGFSVDE 4031 Query: 1318 ARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFA 1377 L ++A + + FM+ A+L+V+L +L TDIA+G+ VA R + A LVG+F Sbjct: 4032 DIHRRLGEVARAHNVSLFMVLHASLSVLLARLSASTDIAIGTAVAGRGDEALENLVGMFV 4091 Query: 1378 NVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNML 1437 N +VLRT++ + +L R L A ++Q++P E+LV+ L P R+ + +PLFQ +L Sbjct: 4092 NTLVLRTEVEPGTSFAELLEQVRTQDLAAFSNQDVPFEQLVDVLKPTRSTAYSPLFQVVL 4151 Score = 499 bits (1285), Expect = e-138 Identities = 396/1254 (31%), Positives = 578/1254 (46%), Gaps = 117/1254 (9%) Query: 48 QRRMWFLQTMDPDDVTLNIC-VAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGE 106 Q M+F + D V + V G+VD RL A ++ARHA LRT + D G Sbjct: 9745 QSGMFFHSVLAEDAVDVYTAQVVLDFQGIVDTGRLRGAAEALIARHANLRTAFVPDDSGT 9804 Query: 107 PYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRAD 166 QV D V + W DL+ L A E ++ S+ ++ FD++ +R +IRT + Sbjct: 9805 AVQVVVDRVALPWEELDLSGLSGAEREERMSSVLSEHRSARFDMSRPPLMRFLLIRTGEN 9864 Query: 167 ELVLLLVVHHICWDDDSWEVFFGELSAAY------NDLPINDPAAQFLSVEVLQNSAAPS 220 + HHI D S + +L Y + LP FL +++ A Sbjct: 9865 SYRFSISNHHILLDGWSMPLLMKDLLVLYATRGDGSVLPRVRGYRDFLGWLSERDTDASR 9924 Query: 221 VADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLF------SRVEDFARKC 274 A WA L G + P ++ R P L + AR Sbjct: 9925 SA----WAHALAGLD------GPTVLAPAPSSEDRPEPAEFALHLGEVVSENLARIARDR 9974 Query: 275 SASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGA---LGYFGNTLLLRITTRS 331 + ++ AA+G+L+ R T + D + V+ R AG +G F NT+ +R+ Sbjct: 9975 GLTMNTIVQAAWGLLLARMTASDDVVFGATVSGRPPEVAGIESMVGLFINTIPIRVRIDP 10034 Query: 332 QDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGM-DLLV--------RLGF 382 +++ + ++ F H +G+ + + A G G+ D L R G Sbjct: 10035 RESLLGLLERLQAEQSTLFDHHHIGLPEIQQIA-----GIGGLFDTLTVFESYPVDRAGL 10089 Query: 383 NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQML 442 GL + GV + A+H PLSL +A ++ + +Y + + L Sbjct: 10090 TEDSDIDGLRVAGVQISD------ASHYPLSL-LAQSDSELQLVLKYLPDVFGADTVERL 10142 Query: 443 VHYLQLVDKALAEPERPL-SSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXX 501 L + + +A L LD+L ER+ VL+ + ++ ++V Sbjct: 10143 GSRLNRILQTIAAGSSTLVGDLDLLTGDERELVLSGWNDSGHDVADESVVSMFGAQVART 10202 Query: 502 XXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVL 561 V+D LTY+E R NRLAR + G GP+ ++G+ M S++ ++++ AV Sbjct: 10203 PDRTAV--VADHVRLTYAEFDARVNRLARHLMSMGVGPDSVVGIAMRRSLDMVISLYAVH 10260 Query: 562 KAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPE----------------LDVAERAAA 605 AG AY+PI+P +P +R Y++ A P V+ + D++E AA Sbjct: 10261 AAGGAYVPIEPEHPADRTSYVVDSAMPTCVLSLADDIANLDVDVPVYLVEDFDLSEYAAG 10320 Query: 606 DNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAE 665 P+ DS+RL LRP +LAY +YTSGSTGRPKGVA+ H A+A + + + A+ Sbjct: 10321 -----PVEDSERLAELRPDNLAYALYTSGSTGRPKGVAIPHAALANQLAWMRDVYGIGAQ 10375 Query: 666 DRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXX 725 D LQ + +FDAS+ ++F+ L +G L++ PD D Y+A + VTV Sbjct: 10376 DVVLQKTPFTFDASVWELFLPLVVGGTLVIASPDGHRDPEYMAATVGTEAVTVIQFVPSV 10435 Query: 726 XXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVV 785 + LR V GGE LP A+R AG AEL N YGPTE + ST VV Sbjct: 10436 LTMFLDAATADRSGSLRLVFAGGEPLPQSAAERVAGLGSAELVNLYGPTEVTINSTAHVV 10495 Query: 786 TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 S A + PIG P N AYVLD L+P P V GELYL G+QLARGY+ L+A+RF Sbjct: 10496 EPSGTATIAPIGSPAWNTRAYVLDAHLNPAPIGVPGELYLDGAQLARGYVNSSALSAERF 10555 Query: 846 IADPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVR 904 +A+PF + G R+YRTGDLVR N G LEFVGR D QVK+RG RIELGEVE + V Sbjct: 10556 VANPFDDSGARMYRTGDLVRWNENGVLEFVGRTDFQVKVRGLRIELGEVEEAFVRYRDVA 10615 Query: 905 HCLVVAEETEAGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVS 963 V+ +E G L AY+VP A +D + A ++PEYM+P + V+ E+P+ S Sbjct: 10616 QAAVIVHNSEVGARLVAYVVPKPDAALDAAALNGFVAESLPEYMIPDSLMVLAELPLGTS 10675 Query: 964 GKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAA 1023 GKLDRRALP P + +R P T TER + ++F +L GR+ VG +DSFF LGG S+++ Sbjct: 10676 GKLDRRALPVPDFASAAEFRAPSTDTERALATVFGELLGRESVGIDDSFFELGGDSIVSI 10735 Query: 1024 RLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFEL-DLDNLAADDMPLDPKRA 1082 +LVA+ R+ G+ T R +F+ T A LAA L + ++ +PL P Sbjct: 10736 QLVARARSA-GIHFTARDVFERRTVAELAAVADSGESAAAALQEYESGGVGTVPLTP--- 10791 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 A G + F MPL L Sbjct: 10792 --------------------VARKMVERGGDFDRFVMPLLLTLPAGIEREQVIATIAAVV 10831 Query: 1143 XRHEALRTNF------DEHEGVPYQIVHPSRTVQ-LAVRAIDQ---DEFDDVST---QLR 1189 +H+ LR+ D E P V TVQ +A+ A D+ EFD V++ Sbjct: 10832 DKHDVLRSTLVTSGVGDALEIAPAGSVDIDATVQRVAIAAGDEPGSPEFDAVASAAFDAA 10891 Query: 1190 RHVFTPESGPLLQANLLVLGP---DTHVLLLIV-HHIVSDHASLEIVFDDLIVA 1239 P +G +LQ + P D LL+V HH+V D S I+ D A Sbjct: 10892 LDRLDPRTGSMLQ--FVWFDPAESDRRGRLLVVPHHLVIDSVSWRILVPDFATA 10943 Score = 479 bits (1232), Expect = e-132 Identities = 442/1449 (30%), Positives = 657/1449 (45%), Gaps = 135/1449 (9%) Query: 27 AEQS----SDQPGICPGER---YRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDED 79 AEQS +++P + P R LS Q RMWF+ D NI +A RL G +D Sbjct: 8150 AEQSDSAGANRPALVPQPRPARIPLSPAQSRMWFINQFDTASAAYNIPLAIRLTGHLDVS 8209 Query: 80 RLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRLPE--AGHERQIE 137 L A+ DVV RH LRTTY DT P QV + D+ + + A ER I Sbjct: 8210 ALEQALGDVVERHETLRTTYP-DTGDGPGQVVLSRTR-SFTSLDVENVADENALRERVIS 8267 Query: 138 SLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYND 197 + A FD+ +P+R ++R A++ VL++VVHHI D S ++ AY+ Sbjct: 8268 LVTAG-----FDVAKTVPVRARLLRIDAEQHVLVIVVHHISSDGASTAPLARDVVIAYSA 8322 Query: 198 LPI-NDPAAQFLSVEVLQNS-----------AAPSVA--DVGYWAETLRXXXXXXXXXGV 243 ++PA L V+ S A+ S+A + YW TL Sbjct: 8323 RAAGSEPAWAPLDVQYADFSLWQHELLGDENASDSLATKQIDYWRTTLSGLPDVLPLPTD 8382 Query: 244 SGANPCR--RAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLV 301 P + R + A L R+ AR+ +AS FMV AA VL+ R + D V Sbjct: 8383 RPRPPAQSMRGANFDFEIDAELRDRLGALAREHNASLFMVAHAALSVLLARLSATDDIAV 8442 Query: 302 SVPVTERSGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRV 360 + R AA L G F NTL+LR TF + +VR+ L F H V +R+ Sbjct: 8443 GTAIEGRGEAALDDLVGMFVNTLVLRAQVDVDKTFADLLAQVRQHDLGAFTHTDVPFERL 8502 Query: 361 VREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIA--- 417 V PER V L F + A L L G+ V L G AA L LT+A Sbjct: 8503 VEILQPERSTAFSPLFQVALAFQNIEQAH-LELPGLTVEGLDGGISAAKFDLQLTLADAA 8561 Query: 418 -LDPD-DVSVEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSV 474 D D + F Y L + + ++++ + + +D+L E +V Sbjct: 8562 GTDGDAPMRGVFTYATDLFDERTIASFAFRFQRILEAITTDASVLIGDIDVLSENEH-AV 8620 Query: 475 LAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIG 534 LA G + A ++ DE ++TY EL R+NRLAR IG Sbjct: 8621 LAPVRG--ADSAAPELLSSILATAAAVDPDAVAVVCGDE-QVTYRELDERSNRLARVMIG 8677 Query: 535 QGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDAR------- 587 +G G +D + L + S+E I+++ AV K GAA++P+DP+YP ERI +++TD+R Sbjct: 8678 RGIGADDFVALALTRSVESILSIWAVAKTGAAFVPVDPSYPFERILHMVTDSRVEVGLTT 8737 Query: 588 -------PQT----VIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGST 636 P T V+G E+D A S ++D+DR+RP R AYVIYTSGST Sbjct: 8738 GAHVGELPDTVRWLVLGEDEMD---GDCASVSSEAVTDADRIRPTRVDDAAYVIYTSGST 8794 Query: 637 GRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVP 696 G PKGV V+H +A V +T + R L F+S SFDAS+ ++ + + +++ Sbjct: 8795 GLPKGVVVTHTGLANVTTEQVERLRLTPQSRVLHFASPSFDASVFELLHAVAAASTMVIA 8854 Query: 697 KPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVA 756 +G +A L+ ++ VT + + V GEA P E+ Sbjct: 8855 SGVVYGG-DELARLLKKQKVTHAFITPAALTTVDPAGLDG----IEVLSVAGEACPPELM 8909 Query: 757 DRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVP 816 ++A + N YGP+EA + ST + V IG P R V VLD +L PVP Sbjct: 8910 QKWAP--GRRMFNLYGPSEATIWSTSS--NPMKADQPVTIGGPTRGVDVVVLDSRLTPVP 8965 Query: 817 DQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGE----- 870 V GELY+ G +ARGY R LTA+RF+A+PF PG RLYRTGD+VR H GE Sbjct: 8966 VGVAGELYVAGPSVARGYHNRFALTAERFVANPFGGPGERLYRTGDVVRWVHDGETGDLV 9025 Query: 871 LEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE--AGPMLAAYLVPAA- 927 L++VGR+D QVK+RGFRIELGE+++ + +HP+V + + E +L +Y++PAA Sbjct: 9026 LDYVGRSDFQVKVRGFRIELGEIDAELGSHPSVDFAVTLGHHRELTGQTVLVSYVMPAAG 9085 Query: 928 AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPI-ATRRYREPE 986 A +D+ E+ A + +P YMVP + I +P+T +GKLDR+ALP P + A Y P Sbjct: 9086 ASIDVAELSAFVSETLPGYMVPSSIMAIDSVPLTPAGKLDRKALPEPQFVSAASEYCAPS 9145 Query: 987 TATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAP 1046 T E+ I +FAQ+ G RV +DSFF LGG S+++ +L + + GV T R +F+ Sbjct: 9146 TPMEKAIADVFAQVLGVDRVSVDDSFFALGGDSIVSIQLTTRAK-NAGVLFTARDVFERK 9204 Query: 1047 TPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWF 1106 T + LA + D++++ +++P G V S +PL + +A W Sbjct: 9205 TVSALADVAA------WATDVESVKLEELP-------GGGVGS-----IPL--TPIAHWL 9244 Query: 1107 QYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDE------HEGVPY 1160 G E+F+ + L RH+ LR+ E + Sbjct: 9245 -VETAGTFEKFSQAVLLTTPPAVTRDQLVATVDAVLERHDILRSRLTRAGDDWAFEALST 9303 Query: 1161 QIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHV------FTPESGPLLQ----ANLLVLGP 1210 + + + + D+ D R + P SG + Q A L Sbjct: 9304 EEAFGADDLIERIEFTDKPGTDGFERLARAALDRAAERLDPASGRMTQFVWFAPAASLPG 9363 Query: 1211 DTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFE 1270 + LL++ HH+V D S ++ D A Q + + +A + Sbjct: 9364 QSGRLLVLAHHLVVDGVSWRVLLPDFATAGSQVTAGQPAQLEPVGSSVRAWAHGLVEEAK 9423 Query: 1271 SNWGQTELDYWRDALAGLPDEISV-ATDRARPRVLGKRGEVVQFSVPAARRAALTQLAE- 1328 S ELD+WR LAG I A D AR V+ + + +A LT + + Sbjct: 9424 SPHRVAELDFWRGMLAGTDPLIGKRAFDPARD-VIARTDRLSMTFSTQVTQALLTTIPQS 9482 Query: 1329 -RNGATEFMLYQAALAVVLHK-LGGGTD---IALGSPVAARVEPAT-----AQLVGLFAN 1378 G + +L ALAV + L GT+ + + R E ++ VG F + Sbjct: 9483 VNGGVNDGLLAALALAVARWRGLRNGTEDRSVLINLEGHGREEATVPGADLSRTVGWFTS 9542 Query: 1379 VVVLRTDLS 1387 + +R D+S Sbjct: 9543 LYPVRLDVS 9551 Score = 446 bits (1148), Expect = e-122 Identities = 387/1296 (29%), Positives = 575/1296 (44%), Gaps = 109/1296 (8%) Query: 61 DVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWR 120 DV L I L G +D D L T + R V+ +G PYQ ++ Sbjct: 3 DVPLTIAQYIELRGDIDLDLL-TEASKRTGREFGSGFLRLVEIDGVPYQYVDKALD---- 57 Query: 121 REDLTRLPEAGHERQIESLAADEFGR-----PFDLTNELPLRITVIRTRADELVLLLVVH 175 + +T + G + ++ AA+++ R P DL + + + ++ + +H Sbjct: 58 -DAITYVDLRGEDDSVD--AAEKWMRANYSAPVDLLEDRLVVVYLLHVGENHYFWFCRIH 114 Query: 176 HICWDDDSWEVFFGELSAAYNDLPIN-DPAA-------QFLSVEVLQNSAAPSVADVGYW 227 HI D ++ Y L +P A + + E ++ D YW Sbjct: 115 HIALDGFGAMALIARIAEIYTALVEGTEPPACRAEDLVRIVEDEQRYRNSERFAKDREYW 174 Query: 228 AETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYG 287 AE G A + A+ LP + +++ +AS +++AA+ Sbjct: 175 AERTAHLPEAPSLAG-RAAMVGKFARLSSEALPESTATLLDEALGGSNASSAPIVVAAFA 233 Query: 288 VLVRRYTGASDFLVSVPVTERSGAAAGALG-YFGNTLLLRITTRSQDTFTSFVNEVRETC 346 + T +D ++S+PV+ R+ A G N + LR+ + T V V+ Sbjct: 234 AYLAHMTDRTDVVLSLPVSARTTATLRRSGGMVSNIVPLRLQITPEMTVPELVKSVQIEL 293 Query: 347 LAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQ--LGLG 404 Q + + R+A + G N+ + L V Q L G Sbjct: 294 TGALRRQRYRHEDIRRDAGAPQ----GQRGFFGPSINIMMFHSEIKLGTVTGHQNVLTTG 349 Query: 405 AVAAHLPLSLTIALDPDDVSVEFEYQQQLSSVLVDQMLVHYLQLVD---KAL-AEPERPL 460 V L L++ + + ++FE L S D++ H+ + D + L A + + Sbjct: 350 PVE-DLSLNIYQGVAGSKIHIDFEANPNLYSA--DELDRHHSRFFDFFERFLGAGDDASV 406 Query: 461 SSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSE 520 S L + ER V+ +G++V PA T+V V D ELTY+E Sbjct: 407 SDLAAMSHEERGQVVTGWNGDVVTPPAGTVVDLFDAQVGRTPDATAL--VFDGEELTYAE 464 Query: 521 LHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERID 580 R NRLAR IG+G GPE + L + S++ +VAM AV+KAG AY+P+D +P ER Sbjct: 465 FDARVNRLARTLIGRGVGPETKVALAIRRSLDSMVAMYAVVKAGGAYVPLDSDHPAERTA 524 Query: 581 YLITDARPQTV--IGRPEL------DVAERAAADNSDLP---LSDSDRLRPLRPGHLAYV 629 Y++ ARP + + R L DV E A D S P + D +R LRP + AYV Sbjct: 525 YVLESARPLCILTVARDGLVFPADQDVLEIDALDLSGAPAGPIRDDERAADLRPANPAYV 584 Query: 630 IYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFL 689 IYTSGSTGRPKGVAVSH ++ V + + + A D LQ + +FD S+ ++F L Sbjct: 585 IYTSGSTGRPKGVAVSHASVLNQVTWIASRYGLDANDVVLQKTPTTFDVSVWELFAALAS 644 Query: 690 GAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGE 749 G++L++ P+ D +Y+AD+I+R VT Q LR V V GE Sbjct: 645 GSRLVIAAPEGHRDPAYLADVIAREKVTATSFVPSMLSVFVAEADREQLVSLRVVLVAGE 704 Query: 750 ALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLD 809 A P VA F DA L N YGPTE V +T V +PIG P N AYVLD Sbjct: 705 AFPPAVAATFRAKSDAGLHNLYGPTEFTVHATAGEV-DRETLHTIPIGTPVWNTEAYVLD 763 Query: 810 EQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHC 868 L P P GELYL G+Q+ARGY GRP LTA+RF+A+PF G RLYRTGDLV+ Sbjct: 764 GHLRPAPIGSAGELYLAGAQVARGYEGRPELTAERFVANPFGAAGTRLYRTGDLVKWRVD 823 Query: 869 GELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVP-AA 927 G +E++GR D QVK+RG RIELGE+E+ ++++P V + V ++ G L Y+VP Sbjct: 824 GSIEYLGRTDFQVKVRGLRIELGEIEAAMSSYPHVAQSVAVVHDSSLGQRLVGYVVPEPG 883 Query: 928 AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIA-TRRYREPE 986 + VD+E++ H AVP YMVP A VI E+P+ SGKLDR+ALP PT A + Y P Sbjct: 884 SAVDVEDLTVHVGRAVPSYMVPDAVVVIAEMPVGASGKLDRKALPEPTFAAESSEYVAPR 943 Query: 987 TATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAP 1046 + E I +FA++ G RV DSFF LGG S+++ +LV++ + E GV T R +F+ Sbjct: 944 STMEESIAGLFAEVLGLPRVSVGDSFFALGGDSIVSIQLVSRAK-EAGVLFTARDVFERK 1002 Query: 1047 TPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWF 1106 T A LA ++ A++ + PG P P+ H + Sbjct: 1003 TVASLA-------------EVAKSASESATVHVLEELPGAGIGTMP-LTPVVH------W 1042 Query: 1107 QYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEH--------EGV 1158 + G F+ + L RH+ALR++ E Sbjct: 1043 MTELGGDFHRFSQSILLALPPKVERDRLVRTLAAVVDRHDALRSSLRRTDSPAGWSLEVA 1102 Query: 1159 PYQIVHPSRTVQ---------------LAVRAIDQ--DEFDDVSTQLRRHVF-------- 1193 P V R V LA A+++ D D + + R V+ Sbjct: 1103 PIGSVDVDRLVDRVEFSEGPGTDSFEALAAHALERTVDTLDPATGSVVRFVWFAPAEDAG 1162 Query: 1194 --TPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQW 1251 P G + P + LL+++HH+ D S ++ D A+ P Sbjct: 1163 DLAPRDGADADSGEGESTPQSGRLLVVIHHLAVDGVSWRVLVPDFASAWAQIAAGADPLL 1222 Query: 1252 DILPIQFADYAVWQRNTFESNWGQTELDYWRDALAG 1287 + +A + S ELD+WR L G Sbjct: 1223 PAVGTSVRRWAHGLADNARSARRVAELDHWRTTLDG 1258 Score = 155 bits (393), Expect = 4e-35 Identities = 155/545 (28%), Positives = 238/545 (43%), Gaps = 45/545 (8%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+ MW + D NI +A RL+G +D D + +AV+DV+ARH LRT + Sbjct: 2605 ERVPLSMAQQSMWLMNRFDTASSAYNIPLAVRLSGSLDIDAMSSAVSDVLARHESLRTVF 2664 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 D PYQ D +V + DLT +P E ++ + + FD+T PLRI Sbjct: 2665 -PDAGDGPYQQIVDTEQVPF---DLTPVPVT--EAELHTALTEFATEGFDVTVAPPLRIR 2718 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFL 208 + T E +L+LVVHHIC D S ++ AY+ LP+ P Sbjct: 2719 LFATSESEFLLVLVVHHICADGASMSPLARDVMVAYSARTAGAAPLWQPLPVQYPDFALW 2778 Query: 209 SVEVLQNSA-APSVA--DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVR---PLPAG 262 EVL + A S+A + +WA+TL + A P R++ R + Sbjct: 2779 QREVLGDPADTQSLAGKQIAHWADTLAGAPELIDLP-LDHARPARQSMRGDSIDFAITPE 2837 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGN 321 L +E ++ AS FMV AA L+ R + + D V P+ RS A L G F N Sbjct: 2838 LRRGLEAVGKERGASLFMVTHAALTTLLSRLSNSDDITVGTPLAARSDQALDDLVGMFVN 2897 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLG 381 TL+LR R D+F V VRE LA F + V +++V R V L Sbjct: 2898 TLVLRTHVRPGDSFAELVERVREGDLAAFGNSDVPFEKIVEALRIRRSAAYSPLFQVMLS 2957 Query: 382 F-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTI------ALDPDDVSVEFEYQQQL- 433 F N R A L L G+ V + A A L+LTI + +P + F + L Sbjct: 2958 FQNNRMDA--LELPGLTVHVIEDMAQGAKYDLTLTITEKADESGEPAGLGGRFTFATDLF 3015 Query: 434 SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKX 493 +++ ++++++ + +P + +DIL ER + L+Q+ PA TM Sbjct: 3016 ERSTAERISERFVRILEAVVTDPGVAVGDIDILTEHER-AKLSQAR------PARTMTVR 3068 Query: 494 XXXXXXXXXXXXXXXXVS---DEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANS 550 V+ D ++TY E R ++ +G GP+ I+ + ++ Sbjct: 3069 ELPQLLAAAVEVAPDAVAVAHDGMQVTYREFDERLRLMSAPLSERGMGPDAIVSVVLSGL 3128 Query: 551 IEFIV 555 + I+ Sbjct: 3129 VPTIM 3133 Score = 146 bits (368), Expect = 3e-32 Identities = 147/551 (26%), Positives = 226/551 (41%), Gaps = 59/551 (10%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 +R LS Q+RMW+ DP+ NI +A RL G +D D L +A+ DVVARH LRT Y Sbjct: 4863 DRLPLSLAQQRMWYANRFDPESAEYNIPLALRLTGALDVDALRSAIADVVARHESLRTVY 4922 Query: 100 GVDTEGEPYQVF--SDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLR 157 +G PYQV + D + G D+ R+ + E+++ FD+T ++P+R Sbjct: 4923 PDSVDG-PYQVVLPASDTKSGL---DVVRVAD---EQELRERVVALASAGFDVTADVPVR 4975 Query: 158 ITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPINDPAAQ 206 + + VL++VVHHI D S +L AY + LP+ P Sbjct: 4976 AALFELGERDHVLVVVVHHISADGSSMAPLARDLFGAYGARVQGEEPGFSPLPVQYPDFA 5035 Query: 207 FLSVEVLQNSAAP-SVA--DVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPAGL 263 +L + P S+A + YW L P R + VR GL Sbjct: 5036 LWQRNLLGSEDDPDSLAGKQIAYWTHALGDAPEVLDL-------PADRPRPAVRNPQGGL 5088 Query: 264 FS---------RVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG 314 + D A+ AS FMV+ A VL+ R + SD VS PV R A Sbjct: 5089 IEFEIGQDVHRSLNDLAQTHQASLFMVVHTALAVLLGRLSNTSDISVSTPVAGRGDRALD 5148 Query: 315 AL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDG 373 L G F NTL+LR F++ + + RE L F + V +++V P R Sbjct: 5149 DLVGMFVNTLVLRTDVDQNARFSTLLTQAREVDLNAFGNADVPFEQIVEVLRPSRTAAYA 5208 Query: 374 MDLLVRLGF-NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE------ 426 V L F N+ + L LDG+ V L G + L + + D+ SV Sbjct: 5209 PLAQVMLSFQNLERPK--LELDGLTVEVLESGLTTSKTDLGVAVEERFDEGSVANGMRGW 5266 Query: 427 FEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA--------Q 477 F Y L V ++++++ + + + +DIL E+ + Sbjct: 5267 FSYATDLFDESTVRGFADRFVRVLEAVTVDADAVVGDIDILTEDEKAGLAVPEEGAQSLM 5326 Query: 478 SHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGF 537 SH E+ AT + + ++TY++L ++ LAR G G Sbjct: 5327 SHSISEELTATKSLPELLDGAASINPDGIALS-HNGTDVTYAQLRDKSAELARTLAGVGI 5385 Query: 538 GPEDIIGLRMA 548 GPE + + ++ Sbjct: 5386 GPEAAVTVALS 5396 Score = 60.1 bits (144), Expect = 3e-06 Identities = 81/325 (24%), Positives = 130/325 (40%), Gaps = 46/325 (14%) Query: 1096 PLSHSQLAAWFQYRI-EGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF-D 1153 PL+ Q +F + E A + + + L F+G RH LRT F Sbjct: 9740 PLAPLQSGMFFHSVLAEDAVDVYTAQVVLDFQGIVDTGRLRGAAEALIARHANLRTAFVP 9799 Query: 1154 EHEGVPYQIVHPSRTVQLAVRAID---------QDEFDDVSTQLRRHVFTPESGPLLQAN 1204 + G Q+V V L +D ++ V ++ R F PL++ Sbjct: 9800 DDSGTAVQVVVDR--VALPWEELDLSGLSGAEREERMSSVLSEHRSARFDMSRPPLMRFL 9857 Query: 1205 LLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILP--IQFADYA 1262 L+ G +++ + HHI+ D S+ ++ DL+V Y R +LP + D+ Sbjct: 9858 LIRTGENSYRFSISNHHILLDGWSMPLLMKDLLVLYATR-----GDGSVLPRVRGYRDFL 9912 Query: 1263 VW--QRNTFESNWGQTELDYWRDALAGLPDEISVA-----TDRARPRVLGKR-GEVVQFS 1314 W +R+T S W ALAGL +A DR P GEVV + Sbjct: 9913 GWLSERDTDASR------SAWAHALAGLDGPTVLAPAPSSEDRPEPAEFALHLGEVVSEN 9966 Query: 1315 VPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATA---Q 1371 L ++A G T + QAA ++L ++ D+ G+ V+ R P A Sbjct: 9967 --------LARIARDRGLTMNTIVQAAWGLLLARMTASDDVVFGATVSGR-PPEVAGIES 10017 Query: 1372 LVGLFANVVVLRTDLSGDPTLRSIL 1396 +VGLF N + +R + +L +L Sbjct: 10018 MVGLFINTIPIRVRIDPRESLLGLL 10042 Score = 59.7 bits (143), Expect = 3e-06 Identities = 39/110 (35%), Positives = 60/110 (54%), Gaps = 9/110 (8%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 +TER L + ELL + D+++F LGGDSI++I+ A+A + G+ F VFE T+ Sbjct: 10700 DTERALATVFGELLGRESVGIDDSFFELGGDSIVSIQLVARARSAGIHFTARDVFERRTV 10759 Query: 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQQG 1667 AELAA D +GE A QEY + G+ L ++ +++G Sbjct: 10760 AELAAVAD--SGESAAAA----LQEY---ESGGVGTVPLTPVARKMVERG 10800 Score = 57.8 bits (138), Expect = 1e-05 Identities = 60/268 (22%), Positives = 109/268 (40%), Gaps = 21/268 (7%) Query: 1154 EHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGP-------LLQANLL 1206 E +GVPYQ V + + A+ +D DD + + S P L+ LL Sbjct: 43 EIDGVPYQYV--DKALDDAITYVDLRGEDDSVDAAEKWMRANYSAPVDLLEDRLVVVYLL 100 Query: 1207 VLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQW----DILPIQFADYA 1262 +G + + +HHI D + + Y A ++ P D++ I + Sbjct: 101 HVGENHYFWFCRIHHIALDGFGAMALIARIAEIYTALVEGTEPPACRAEDLVRIVEDEQR 160 Query: 1263 VWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAA 1322 F + +YW + A LP+ S+A R ++GK + ++P + Sbjct: 161 YRNSERFAK-----DREYWAERTAHLPEAPSLA---GRAAMVGKFARLSSEALPESTATL 212 Query: 1323 LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVL 1382 L + + A+ + AA A L + TD+ L PV+AR + G+ +N+V L Sbjct: 213 LDEALGGSNASSAPIVVAAFAAYLAHMTDRTDVVLSLPVSARTTATLRRSGGMVSNIVPL 272 Query: 1383 RTDLSGDPTLRSILVGSRDTVLDALAHQ 1410 R ++ + T+ ++ + + AL Q Sbjct: 273 RLQITPEMTVPELVKSVQIELTGALRRQ 300 Score = 46.6 bits (109), Expect = 0.030 Identities = 24/74 (32%), Positives = 41/74 (55%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E + + E+L + + +++FALGGDSI++I+ ++A G+ F VFE T+A Sbjct: 947 EESIAGLFAEVLGLPRVSVGDSFFALGGDSIVSIQLVSRAKEAGVLFTARDVFERKTVAS 1006 Query: 1620 LAAAVDAANGEPVV 1633 LA +A+ V Sbjct: 1007 LAEVAKSASESATV 1020 Score = 46.6 bits (109), Expect = 0.030 Identities = 27/85 (31%), Positives = 47/85 (55%), Gaps = 5/85 (5%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIA 1618 E+R+ A+ E+L + + D+++F LGG+S+ A + A+ A+G+ P +FE T+A Sbjct: 4778 EQRVAAVFAEVLGVDVVGADDSFFTLGGNSLAATRVMARINEAVGIDAPVREIFEAPTVA 4837 Query: 1619 ELAAAVDA----ANGEPVVEADPPP 1639 +LA ++ P V A P P Sbjct: 4838 QLARRLEELGVDGGARPPVTAGPRP 4862 Score = 45.8 bits (107), Expect = 0.052 Identities = 23/60 (38%), Positives = 39/60 (65%), Gaps = 3/60 (5%) Query: 1565 AMLEELLEITGIDR---DENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAELA 1621 A+ + ++ G+DR D+++FALGGDSI++I+ + +A G+ F VFE T++ LA Sbjct: 9151 AIADVFAQVLGVDRVSVDDSFFALGGDSIVSIQLTTRAKNAGVLFTARDVFERKTVSALA 9210 Score = 43.5 bits (101), Expect = 0.26 Identities = 25/71 (35%), Positives = 40/71 (56%), Gaps = 1/71 (1%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMTIA 1618 E + + E+L + + +++F LGG+SI A + +A+ ALG FEH T+A Sbjct: 5966 EEIVAGVFAEVLGVERVGTADSFFDLGGNSISATRLTARLTAALGAQLSVRECFEHPTVA 6025 Query: 1619 ELAAAVDAANG 1629 ELAA ++A G Sbjct: 6026 ELAALLEATAG 6036 >tr|Q5Z1X7|Q5Z1X7_NOCFA Tax_Id=37329 SubName: Full=Putative non-ribosomal peptide synthetase;[Nocardia farcinica] Length = 3030 Score = 762 bits (1968), Expect = 0.0 Identities = 512/1449 (35%), Positives = 713/1449 (49%), Gaps = 75/1449 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+RMWFL +P+ NI +A RL+G +D L A+ D+V RH +LRT Y Sbjct: 622 ERIPLSLAQQRMWFLNRFEPESAAYNIPIAIRLSGALDVPALGQAIADLVGRHEVLRTVY 681 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 G P QV + E PE Q+ + A+ G FD+T E+PLR+ Sbjct: 682 PETAHG-PVQVILPAGDASPELEVRDVAPE-----QVRAAVAELLGAGFDVTREVPLRVV 735 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFL 208 + R A++ VL + VHHI D S +L AY LP+ Sbjct: 736 LFRVTAEDFVLAMSVHHISGDGSSGGPLTRDLMTAYAARAAGHAPEWAPLPVQYADYSIW 795 Query: 209 SVEVL---QNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPL--PAGL 263 EVL + +P+ + YW + L + Q V + A L Sbjct: 796 QREVLGSEDDPESPAAKQIAYWRDQLAGLPDQLDLPTDRPRPAVQSFQGSVVDIRIDAEL 855 Query: 264 FSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNT 322 + + AR A+ FMV+ A VL+ R +G D V P+ R A L G F NT Sbjct: 856 HRGLVELARAEGATLFMVVHTALAVLLARLSGGDDVAVGTPIAGRGEAVLDDLIGMFVNT 915 Query: 323 LLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGF 382 L+ R + FT + RET L FAH V +R+V NP R V L F Sbjct: 916 LVFRSRVDGAEPFTELLARQRETDLQAFAHADVPFERLVEVLNPVRSTARHPLFQVGLSF 975 Query: 383 NMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE------FEYQQQLSSV 436 A L L G+ V L + + L + D+ Y L Sbjct: 976 QNLAEAS-LELPGLRVSGLDVDVHVSQFDLHWIVGDRYDESGAPAGMGGALTYATALFDR 1034 Query: 437 LVDQMLVH-YLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 ++ V +++L+ +A P + LD+L ER +L + + T+ Sbjct: 1035 ATAEVFVERFVRLLRAVVAAPRTAVGDLDLLEPAERQRLLVDVNATDHPLTPGTLADLLD 1094 Query: 496 XXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIV 555 D +++ EL R + +AR I +G GPED + L + ++ +V Sbjct: 1095 ASAAAASGHAVALVGPDGGRVSWPELDARVDSVARVLISRGVGPEDRVALALRRGVDLVV 1154 Query: 556 AMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPEL----DVAERAAADNSDL- 610 AM AV +AG AY+P+DP ER DY++ A P V+ D+A A D +++ Sbjct: 1155 AMYAVARAGGAYVPVDPDQAAERTDYILRTAAPVLVLTDAATGFTTDIAPVLAVDGAEVA 1214 Query: 611 -----PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAE 665 P++D+DRL PLRP H AYVI+TSGSTGRPKGVAV H A+ ++ V+E+ +TA+ Sbjct: 1215 VTPPAPITDADRLAPLRPDHTAYVIFTSGSTGRPKGVAVPHAAVVNQLRWKVSEFELTAD 1274 Query: 666 DRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXX 725 D L ++ +FD S+ + + G +L++ PD D +Y+ +L++R GVT Sbjct: 1275 DAVLLKTAATFDLSVWEFWSAAACGGRLVIASPDGHRDPAYLTELMAREGVTTLHLVPSM 1334 Query: 726 XXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVV 785 LR V GEALP A R A L N YGPTEA V T+ +V Sbjct: 1335 LDALLTASGDALPGSLRRVLAIGEALPAASAQR-ALRTGTALFNLYGPTEAAVSITNHLV 1393 Query: 786 TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRF 845 T + + VPIG P N YVLD +L PVP V GELYL G+QLARGY GRP LTA+RF Sbjct: 1394 TEADRS-TVPIGAPEWNSRVYVLDGRLRPVPVGVSGELYLAGTQLARGYFGRPELTAERF 1452 Query: 846 IADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRH 905 +A+PF PG R+YRTGD+V N GEL++ GR D QVKIRGFRIELGE+E+V+ P V Sbjct: 1453 VANPFTPGARMYRTGDVVAWNAAGELDYRGRTDFQVKIRGFRIELGEIEAVLQAQPGVAA 1512 Query: 906 CLVVA-EETEAGPMLAAYLVPA--AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTV 962 V A + G L Y+VPA AA+VD I+ A +P YMVP AF V+ +P+ V Sbjct: 1513 AAVAAHSDPHTGDRLVGYVVPADPAAEVDTAAIKTALATELPSYMVPSAFVVLDALPLNV 1572 Query: 963 SGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLA 1022 +GKLDR+ALP P R +R P T E + IF + G +RVGA+D FF LGG+SL+A Sbjct: 1573 NGKLDRKALPEPV-FEPREFRAPTTPVEEIVAEIFTDVLGVERVGADDDFFALGGNSLIA 1631 Query: 1023 ARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRA 1082 + A+I A ++ VR +F+A T A LA R+ + Sbjct: 1632 TQAAARIGAALDTEVPVRLLFEAATVAALAVRVEAQ-------------------AGAGR 1672 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 RP RP+R+PLS +Q W I+G +N+P A+R G Sbjct: 1673 RPALTPRPRPERIPLSPAQQRMWLLNGIDGGAAVYNIPAAVRLTGTLSVPALQQAVADVL 1732 Query: 1143 XRHEALRTNFDEHEGVPYQIVHPSRTV--QLAVRAIDQDEF-DDVSTQLRRHVFTPESGP 1199 RHE LRT + H+G +Q+V P V L R + + ++ +L P Sbjct: 1733 ARHEVLRTVYPAHDGTAHQVVLPVDHVVPDLTPRVVPAAALREHIAAELGTGFDVTREVP 1792 Query: 1200 LLQANLLVL-GPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQF 1258 + V P HVL+L+VHHI +D S+ DL+VAY AR AP W LP+Q+ Sbjct: 1793 VRAVLFRVAEDPAEHVLVLVVHHIAADGWSMAPFTRDLMVAYAAREIGEAPSWQPLPVQY 1852 Query: 1259 ADYAVWQRNTF-----ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQF 1313 AD+++WQR ++ +L YWR ALAGLPD +S+ DR RP + V Sbjct: 1853 ADFSLWQRELLGDENDPASPAARQLAYWRTALAGLPDALSLPFDRPRPAIQETAARAVAV 1912 Query: 1314 SVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLV 1373 + A AL +LA AT FM+ ALAV+L + DIA+G+PVA R + A LV Sbjct: 1913 HIDARTHRALLELARAQHATLFMVVHTALAVLLARWSRADDIAIGTPVAGRGDAALDDLV 1972 Query: 1374 GLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLF 1433 G+F N +VLRT + +L RDT L A A+ ++P E LV+ LNP R+ +R+P+F Sbjct: 1973 GMFVNTLVLRTRVDSATLFTELLARQRDTDLAAYANADVPFEHLVDVLNPVRSTARHPVF 2032 Query: 1434 QNMLNFRGE 1442 Q ML F+ + Sbjct: 2033 QVMLAFQNQ 2041 Score = 592 bits (1527), Expect = e-166 Identities = 367/958 (38%), Positives = 516/958 (53%), Gaps = 61/958 (6%) Query: 515 ELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAY 574 +LTY+EL R+ RLAR I +G GPED++ L + S++ ++A AV K GA ++P+DP Y Sbjct: 48 QLTYAELDERSTRLARALIARGIGPEDLVALGIPRSVDSVLACWAVAKTGAGFVPVDPNY 107 Query: 575 PDERIDYLITDARPQTVIGRPELDVAERAAAD-----------------NSDLPLSDSDR 617 P +R+ +++ D+ V+G DV + D S P++ +DR Sbjct: 108 PADRVAHMLGDSG--AVVGITVADVRDDLPGDVEWLVLDDPATVDLLAAQSGEPVTGADR 165 Query: 618 LRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFD 677 +RPL H AYVIYTSGSTG PKGV V+ +A + + +T E R L F+S SFD Sbjct: 166 VRPLLAEHPAYVIYTSGSTGLPKGVVVTQAGLASFCEEQRERYRVTEESRTLHFASPSFD 225 Query: 678 ASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQ 737 AS+ ++ + L A ++V P +G +A L+ R GVT Sbjct: 226 ASVLELLLALGGAATMVVVSPTVYGGAE-LAGLLRRTGVTHAFITPAALASIDPTGLD-- 282 Query: 738 WRQLRHVPVGGEALPGEVADRFA----GYFDAELRNHYGPTEAVVCSTHMVVTGSHGARV 793 LR V GGEA P E+ R+A G E N YGPTE + + + + Sbjct: 283 --DLRVVVAGGEACPPELVRRWAVPLAGGSVREFYNGYGPTETTIMTN--ISEPLRPGEL 338 Query: 794 VPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-P 852 V IG P RNV AYVLD +L VP V+GELYL G+QLARGY RP +TA RF+A+PF Sbjct: 339 VTIGAPIRNVAAYVLDSRLRLVPTGVVGELYLSGAQLARGYGNRPGMTAGRFVANPFTGD 398 Query: 853 GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEE 912 G R+YRTGDLVRR G LE++GR D QVKIRGFRIELGE+++V+ +H V + V Sbjct: 399 GARMYRTGDLVRRTASGALEYLGRNDFQVKIRGFRIELGEIDAVLASHENVDFAVTVGHR 458 Query: 913 TEAGPMLAAYLVPAA--AQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRA 970 + G + A V AA + +D E+ A +P +MVP + V+ EIP+T GKLDRRA Sbjct: 459 LDNGSTILAAYVHAADGSPLDTAELTALAEQQLPAHMVPTSITVLDEIPLTPVGKLDRRA 518 Query: 971 LPAPTPIATRRYREPETATERWICSIFAQLFGR-QRVGAEDSFFGLGGHSLLAARLVAQI 1029 LPAP + T+ +R P E + +F + G +GA D FF LGG+SL+A ++ A++ Sbjct: 519 LPAPA-LHTKEFRAPAGRFEEMVAQVFDDVVGDGSPIGAADDFFELGGNSLIATQVAARL 577 Query: 1030 RAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKS 1089 A + R IF+APT A LA R+ E L + R Sbjct: 578 GALLETKVPTRLIFEAPTVARLAERIAE-------------------LSGQGGRTELRSG 618 Query: 1090 ARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALR 1149 RP+R+PLS +Q WF R E +N+P+A+R G RHE LR Sbjct: 619 PRPERIPLSLAQQRMWFLNRFEPESAAYNIPIAIRLSGALDVPALGQAIADLVGRHEVLR 678 Query: 1150 TNFDEHEGVPYQIVHPS--RTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLV 1207 T + E P Q++ P+ + +L VR + ++ +L F L+ L Sbjct: 679 TVYPETAHGPVQVILPAGDASPELEVRDVAPEQVRAAVAELLGAGFDVTREVPLRVVLFR 738 Query: 1208 LGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRN 1267 + + VL + VHHI D +S + DL+ AY AR +AP+W LP+Q+ADY++WQR Sbjct: 739 VTAEDFVLAMSVHHISGDGSSGGPLTRDLMTAYAARAAGHAPEWAPLPVQYADYSIWQRE 798 Query: 1268 TFES-----NWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAA 1322 S + ++ YWRD LAGLPD++ + TDR RP V +G VV + A Sbjct: 799 VLGSEDDPESPAAKQIAYWRDQLAGLPDQLDLPTDRPRPAVQSFQGSVVDIRIDAELHRG 858 Query: 1323 LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVL 1382 L +LA GAT FM+ ALAV+L +L GG D+A+G+P+A R E L+G+F N +V Sbjct: 859 LVELARAEGATLFMVVHTALAVLLARLSGGDDVAVGTPIAGRGEAVLDDLIGMFVNTLVF 918 Query: 1383 RTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 R+ + G +L R+T L A AH ++P ERLVE LNP R+ +R+PLFQ L+F+ Sbjct: 919 RSRVDGAEPFTELLARQRETDLQAFAHADVPFERLVEVLNPVRSTARHPLFQVGLSFQ 976 Score = 555 bits (1430), Expect = e-155 Identities = 392/1066 (36%), Positives = 535/1066 (50%), Gaps = 59/1066 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+RMW L +D NI A RL G + L AV DV+ARH +LRT Y Sbjct: 1683 ERIPLSPAQQRMWLLNGIDGGAAVYNIPAAVRLTGTLSVPALQQAVADVLARHEVLRTVY 1742 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 +G +QV + V DLT P + A E G FD+T E+P+R Sbjct: 1743 PAH-DGTAHQVV---LPVDHVVPDLT--PRVVPAAALREHIAAELGTGFDVTREVPVRAV 1796 Query: 160 VIRTRAD--ELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPIND-PAAQFLSVEVLQNS 216 + R D E VL+LVVHHI D S F +L AY I + P+ Q L V+ S Sbjct: 1797 LFRVAEDPAEHVLVLVVHHIAADGWSMAPFTRDLMVAYAAREIGEAPSWQPLPVQYADFS 1856 Query: 217 -------------AAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRP--LPA 261 A+P+ + YW L + R + A Sbjct: 1857 LWQRELLGDENDPASPAARQLAYWRTALAGLPDALSLPFDRPRPAIQETAARAVAVHIDA 1916 Query: 262 GLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFG 320 + + AR A+ FMV+ A VL+ R++ A D + PV R AA L G F Sbjct: 1917 RTHRALLELARAQHATLFMVVHTALAVLLARWSRADDIAIGTPVAGRGDAALDDLVGMFV 1976 Query: 321 NTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRL 380 NTL+LR S FT + R+T LA +A+ V + +V NP R V L Sbjct: 1977 NTLVLRTRVDSATLFTELLARQRDTDLAAYANADVPFEHLVDVLNPVRSTARHPVFQVML 2036 Query: 381 GFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIAL------DPDDVSVEFEYQQQLS 434 F + AG L L G+ V + + L L +A +P ++ + Y L Sbjct: 2037 AFQNQARAG-LELPGLSVSAMEFESEQTEYDLQLMVADGYDEHGEPTGIAGKVVYPTSLF 2095 Query: 435 SVLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVL----AQSHGELVEMPATT 489 + + V ALAE P RP+ +D L ER VL A +H + Sbjct: 2096 DAATIEGFARRFERVLAALAEEPGRPVGDVDWLTDAERTEVLTTRNATAHPLDESATLVS 2155 Query: 490 MVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMAN 549 +V +E++Y+E RANRLAR I G GP + + + Sbjct: 2156 LVATGTRIDPDAVALVDGALTDQRSEVSYAEFDARANRLARHLISLGVGPGSRVVVALHR 2215 Query: 550 SIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDV-AERAAA--- 605 S++ +VA+ AVL+ GAAY+P+DP +P ER Y++ + P V+ D ERA Sbjct: 2216 SVDLLVAIHAVLRTGAAYVPVDPDHPAERTAYVLDLSEPSCVLTHAAADFRTERAPVLHV 2275 Query: 606 DNSDL------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAE 659 D DL P++D+DR PLRP AY+++TSGSTGRPKGVAV H A+A HV+ FVAE Sbjct: 2276 DALDLSGYPADPVTDADRRAPLRPADTAYILFTSGSTGRPKGVAVPHRAVANHVRWFVAE 2335 Query: 660 WTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVX 719 + + A D L ++++FD S+ D+FV G ++++ D D Y+A++I+ VTV Sbjct: 2336 YGIGAADVSLFKTTITFDMSVWDVFVPFVTGGRVVIAGRDGHRDPRYLAEVIAAERVTVI 2395 Query: 720 XXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTE-AVV 778 LR + + GEAL E A A L N YGPTE AVV Sbjct: 2396 PFVPSMLRAIVDTLDGAALDTLRVIWLAGEALSAETAAAARRVSRARLDNLYGPTETAVV 2455 Query: 779 CSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRP 838 T V + G +VPIG P NV AYVLD++L PVP V GELY G QL+ GY GRP Sbjct: 2456 TMTARVPADAAG--IVPIGAPIWNVRAYVLDDRLRPVPVGVAGELYHAGIQLSHGYFGRP 2513 Query: 839 TLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVIT 898 LTA RF+A PF G RLYRTGDLVR G++E++GR D QVK+RG RIELGE+E+ + Sbjct: 2514 DLTAARFVASPFGDGERLYRTGDLVRWTTDGQVEYLGRTDFQVKVRGLRIELGEIETALL 2573 Query: 899 THPAVRHCLVVAE-ETEAGPMLAAYLVPA-------AAQVDLEEIRAHTAAAVPEYMVPG 950 H AVR +VV + + G L Y+VP ++D E +RAH AA VP YMVP Sbjct: 2574 GHDAVRQAVVVVHTDAQLGDQLVGYVVPEPGGVAQDGGELDAEALRAHLAALVPSYMVPA 2633 Query: 951 AFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAED 1010 AF ++ E+P+ +GKLDR+ LP P A R R+ T ER I +FA++ G + VG +D Sbjct: 2634 AFVLLAELPLNANGKLDRKMLPEP-EFAARSQRQARTPLERTITGVFAEVLGLESVGMDD 2692 Query: 1011 SFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLV 1056 SFF LGG+SL+A R A++ E G+ + V +F PTPAG+A +++ Sbjct: 2693 SFFELGGNSLVATRAAARLGEELGLRVPVVWLFTTPTPAGIAGQVL 2738 Score = 48.1 bits (113), Expect = 0.010 Identities = 35/97 (36%), Positives = 55/97 (56%), Gaps = 10/97 (10%) Query: 1561 RRLTAMLEELL-----EITGIDR---DENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMV 1611 R T +EE++ ++ G++R D+++FALGG+S+IA + +A+ G AL P ++ Sbjct: 1592 RAPTTPVEEIVAEIFTDVLGVERVGADDDFFALGGNSLIATQAAARIGAALDTEVPVRLL 1651 Query: 1612 FEHMTIAELAAAVDAANGEPVVEA-DPPPAQEYTPMS 1647 FE T+A LA V+A G A P P E P+S Sbjct: 1652 FEAATVAALAVRVEAQAGAGRRPALTPRPRPERIPLS 1688 >tr|Q50E74|Q50E74_STRFL Tax_Id=67294 (dptA)SubName: Full=Peptide synthetase 1;[Streptomyces filamentosus] Length = 5830 Score = 761 bits (1965), Expect = 0.0 Identities = 536/1520 (35%), Positives = 752/1520 (49%), Gaps = 103/1520 (6%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS Q+R+WFL ++ + NI +A RL G +D L A+ DV+ARH LRT D Sbjct: 3678 LSFAQQRLWFLHQLEGPNAAYNIPMALRLTGRLDLTALEAALTDVIARHESLRTVIAQDD 3737 Query: 104 EGEPYQVF--SDDVEVGWRREDLTRLPEAGHERQIESLAADEFGR-PFDLTNELPLRITV 160 G +Q +DD L +P H Q DE R PFDLT E+PLR TV Sbjct: 3738 SGGVWQNILPTDDTRT---HLTLDTMPVDAHTLQNR---VDEAARHPFDLTTEIPLRATV 3791 Query: 161 IRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-DLPINDPAAQFLSVEVLQ----- 214 R DE VLLLV+HHI D S +LSAAY L + P L+V+ Sbjct: 3792 FRVTDDEHVLLLVLHHIAGDGWSMAPLAHDLSAAYTVRLEHHAPQLPALAVQYADYAAWQ 3851 Query: 215 --------NSAAPSVADVGYWAETLRXXXXXXXXXG-----VSGANPCRRAQRRVRPLPA 261 N+++ + YW L ++ C R + V P Sbjct: 3852 RDVLGTENNTSSQLSTQLDYWYSKLEGLPAELTLPTSRVRPAVASHACDRVEFTV---PH 3908 Query: 262 GLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAA-GALGYFG 320 + + AR A+ FMV+ AA L+ R +D + P+ R+ A +G F Sbjct: 3909 DVHQGLTALARTQGATVFMVVQAALAALLSRLGAGTDIPIGTPIAGRTDQAMENLIGLFV 3968 Query: 321 NTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRL 380 NTL+LR TF + VR T L +AHQ + +R+V NPER V L Sbjct: 3969 NTLVLRTDVSGDPTFAELLARVRTTALDAYAHQDIPFERLVEAINPERSLTRHPLFQVML 4028 Query: 381 GFNMRKSAGGL----ALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE--FEYQQQL- 433 FN L A+ G+ R + AV + L+ + P + +Y L Sbjct: 4029 AFNNTDRRSALDALDAMPGLHARPADVLAVTSPYDLAFSFVETPGSTEMPGILDYATDLF 4088 Query: 434 SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKX 493 + M ++L+ + PE + + IL A E ++ ++ E+ +T+ + Sbjct: 4089 DRSTAEAMTERLVRLLAEIARRPELSVGDIGILSADEVKALSPEAPPAAEELHTSTLPEL 4148 Query: 494 XXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEF 553 V + EL+Y EL+ RANRLAR + +G GPE +G+ + ++ Sbjct: 4149 FEEQVAARGHAVAV--VCEGEELSYKELNARANRLARVLMERGAGPERFVGVALPRGLDL 4206 Query: 554 IVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDV---AERAAADNSDL 610 IVA+LAV K GAAY+P+DP YP +R+ Y++TDA P V+ ++ + A R D+ + Sbjct: 4207 IVALLAVTKTGAAYVPLDPEYPTDRLAYMVTDANPTAVVTSTDVHIPLIAPRIELDDEAI 4266 Query: 611 --PLSDSDRLRPL---RPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAE 665 L+ + P P H AYVIYTSGSTGRPKGV +SH + + + Sbjct: 4267 RTELAAAPDTAPCVGSGPAHPAYVIYTSGSTGRPKGVVISHANVVRLFTACSDSFDFGPD 4326 Query: 666 DRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXX 725 W F S +FD S+ +I+ L G +L+V + + L++ + VT+ Sbjct: 4327 HVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPFEVTRSPAEFLALLAEQQVTLLSQTPSA 4386 Query: 726 XXXXXXXXXXXQWR----QLRHVPVGGEALPGEVADRFAGYFDAELR------NHYGPTE 775 R LRHV GGEAL R +FD L N YG TE Sbjct: 4387 FHQLTEAARQEPARCAGLALRHVVFGGEALD---PSRLRDWFDLPLGSRPTLVNMYGITE 4443 Query: 776 AVVCSTHMVV----TGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLA 831 V T + + T G+ PIG P ++ YVLDE+L PVP +GE+Y+ G+ LA Sbjct: 4444 TTVHVTVLPLEDRATSLSGS---PIGRPLADLQVYVLDERLRPVPPGTVGEMYVAGAGLA 4500 Query: 832 RGYLGRPTLTAQRFIADPFN-PGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIEL 890 RGYLGRP LTA+RF+ADP + G RLYRTGDL + G LE+VGR D QVKIRGFRIEL Sbjct: 4501 RGYLGRPALTAERFVADPNSRSGGRLYRTGDLAKVRPDGGLEYVGRGDRQVKIRGFRIEL 4560 Query: 891 GEVESVITTHPAVRHCLV-VAEETEAGPMLAAYLVPAAAQ--VDLEEIRAHTAAAVPEYM 947 GE+E+ + TH V +V V +E L A++VPA L E+ H AA +P YM Sbjct: 4561 GEIEAALVTHAGVVQAVVLVRDEQTDDQRLVAHVVPALPHRAPTLAELHEHLAATLPAYM 4620 Query: 948 VPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVG 1007 VP A+ + E+P+T +GKLDR AL TR R P T E +C +FA + G Sbjct: 4621 VPSAYRTLDELPLTANGKLDRAALAGQWQGGTRTRRLPRTPQEEILCELFADVLRLPAAG 4680 Query: 1008 AEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDL 1067 A+D FF LGGHSLLA RL++ +R GV+L +R +F APTPAGLA L Sbjct: 4681 ADDDFFALGGHSLLATRLLSAVRGTLGVELGIRDLFAAPTPAGLATVL------------ 4728 Query: 1068 DNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEG 1127 AA L P RP+RLPLS +Q WF ++EG +N+P+A+R G Sbjct: 4729 ---AASGTALPPVTRI-----DRRPERLPLSFAQRRLWFLSKLEGPSATYNIPVAVRLTG 4780 Query: 1128 PXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQ 1187 RHE+LRT F + G P Q+V P + E + + Sbjct: 4781 ALDVPALRAALGDVTARHESLRTVFPDDGGEPRQLVLPHAEPPFLTHEVTVGEVAEQAAS 4840 Query: 1188 LRRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHN 1247 + F S L+A LL + P+ HVL++++HHI D S+ + DL+ AYRAR + + Sbjct: 4841 ATGYAFDITSDTPLRATLLRVSPEEHVLVVVIHHIAGDGWSMGPLVRDLVTAYRARTRGD 4900 Query: 1248 APQWDILPIQFADYAVWQRNTF---ESNWGQT--ELDYWRDALAGLPDEISVATDRARPR 1302 AP++ LP+Q+ADYA+WQ ++ G+T L YWR+ LAGLP+E ++ DR RP Sbjct: 4901 APEYTPLPVQYADYALWQHAVAGDEDAPDGRTARRLGYWREMLAGLPEEHTLPADRPRPV 4960 Query: 1303 VLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVA 1362 RG V+F +PA +L +A AT FM+ QAALA +L +LG G DI +G+PVA Sbjct: 4961 RSSHRGGRVRFELPAGVHRSLLAVARDRRATLFMVVQAALAGLLSRLGAGDDIPIGTPVA 5020 Query: 1363 ARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALN 1422 R + A +VG F N +VLRT+L+GDP+ ++ R LDA AHQ++P ERLVEAL Sbjct: 5021 GRGDEALDDVVGFFVNTLVLRTNLAGDPSFADLVDRVRTADLDAFAHQDVPFERLVEALA 5080 Query: 1423 PPRALSRNPLFQNMLNFRGEDWALVPRDLTGRGETTVVPLPVNFEVALLFLAIGMSV--T 1480 P R+L+R+PLFQ D + + L T P+ A L+ + T Sbjct: 5081 PRRSLARHPLFQIWYTLTNADQDITGQALNALPGLTGDEYPLGASAAKFDLSFTFTEHRT 5140 Query: 1481 PSGE---LDVQVIANADLYE 1497 P G+ L V + ++DLY+ Sbjct: 5141 PDGDAAGLSVLLDYSSDLYD 5160 Score = 687 bits (1772), Expect = 0.0 Identities = 496/1432 (34%), Positives = 689/1432 (48%), Gaps = 79/1432 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAY-RLAGLVDEDRLHTAVNDVVARHAILRTT 98 +R ++ Q+ +W + DD L C AY L G +D L TAV + LRT Sbjct: 6 QRLGVTAAQQSVWLAGQL-ADDHRLYHCAAYLSLTGSIDPRTLGTAVRRTLDETEALRTR 64 Query: 99 YGVDTEGEPYQVFSDDVEVGWRREDLTRLPE---AGHERQIESLAADEFGRPFDLTNELP 155 + V +GE Q+ D + P+ A H+ +LAA P L Sbjct: 65 F-VPQDGELLQILEPGAGQLLLEADFSGDPDPERAAHDWMHAALAA-----PVRLDRAGT 118 Query: 156 LRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPIND--------PAAQF 207 ++ +L HHI D + L+ Y L D P A Sbjct: 119 ATHALLTLGPSRHLLYFGYHHIALDGYGALLHLRRLAHVYTALSNGDDPGPCPFGPLAGV 178 Query: 208 LSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSG--ANPCRRAQRRVRPLPAGLFS 265 L+ E + D +W +L G+S A RR L Sbjct: 179 LTEEAAYRDSDNHRRDGEFWTRSLAGADEAP---GLSEREAGALAVPLRRTVELSGERTE 235 Query: 266 RVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTER-SGAAAGALGYFGNTLL 324 ++ A A +L+AA VRR+ A D ++ +PVT R +G A N + Sbjct: 236 KLAASAAATGARWSSLLVAATAAFVRRHAAADDTVIGLPVTARLTGPALRTPCMLANDVP 295 Query: 325 LRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNM 384 LR+ R F + + + HQ + + R N +GR L R+ N+ Sbjct: 296 LRLDARLDAPFAALLADTTRAVGTLARHQRFRGEELHR--NLGGVGRTAG--LARVTVNV 351 Query: 385 RKSAGGLALDG--VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQLSSV--LVDQ 440 + VV +L G V S PD V + F L + L D Sbjct: 352 LAYVDNIRFGDCRAVVHELSSGPVRDFHINSYGTPGTPDGVQLVFSGNPALYTATDLADH 411 Query: 441 MLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXX 500 +L+ +D A+P+ P +L G R +L S G +P T+ + Sbjct: 412 Q-ERFLRFLDAVTADPDLPTGRHRLLSPGTRARLLDDSRGTERPVPRATLPELFAEQARR 470 Query: 501 XXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAV 560 D LTY +LHR R A G G ED++ L + S E + +L + Sbjct: 471 TPDAPAVQH--DGTVLTYRDLHRSVERAAGRLAGLGLRTEDVVALALPKSAESVAILLGI 528 Query: 561 LKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELD-----VAERAAADNSDLPLSDS 615 +AGAAY+P+DP +P ER+ ++ D RP+ ++ +D + AAAD + Sbjct: 529 QRAGAAYVPLDPTHPAERLARVLDDTRPRYLVTTGHIDGLSHPTPQLAAADLLREGGPEP 588 Query: 616 DRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 RP PG+ AY+I TSGSTGRPKGV V+H +A + + + R LQF S Sbjct: 589 APGRPA-PGNAAYIIQTSGSTGRPKGVVVTHEGLATLAADQIRRYRTGPDARVLQFISPG 647 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FD ++++ +TL G L++P G ++AD ++ VT Sbjct: 648 FDVFVSELSMTLLSGGCLVIPPDGLTG--RHLADFLAAEAVTTTSLTPGALATMPATDLP 705 Query: 736 XQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGS-HGARVV 794 LR + VGGE P E+ D++ D + N YGPTE V +T G+ HG V Sbjct: 706 ----HLRTLIVGGEVCPPEIFDQWGRGRD--IVNAYGPTETTVEATAWHRDGATHGP--V 757 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNP-G 853 P+G P N YVLD L PVPD GELYL G LARGY+ P TA+RF+ADPF P G Sbjct: 758 PLGRPTLNRRGYVLDPALEPVPDGTTGELYLAGEGLARGYVAAPGPTAERFVADPFGPPG 817 Query: 854 MRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEET 913 R+YRTGDLVRR G LEFVGRAD QVK+RGFRIELGEV++ +T P VR V+ E Sbjct: 818 SRMYRTGDLVRRRSGGMLEFVGRADGQVKLRGFRIELGEVQAALTALPGVRQAGVLIRED 877 Query: 914 EAG-PMLAAYLVPA-AAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRAL 971 G P L Y+VPA A+ D E+RA A +P +MVP A +P +P+T +GKLDR AL Sbjct: 878 RPGDPRLVGYIVPAPGAEPDAGELRAALARTLPPHMVPWALVPLPALPLTSNGKLDRAAL 937 Query: 972 PAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRA 1031 P P A + P T E+ +C++FA + G V +D FF LGGHSL RL+A+IR Sbjct: 938 PVPAARAGGSGQRPVTPQEKTLCALFADVLGVTEVATDDVFFELGGHSLNGTRLLARIRT 997 Query: 1032 EFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSAR 1091 EFG DLT+R +F PT AGL L + R PL P R Sbjct: 998 EFGTDLTLRDLFAFPTVAGLLPLLDDNGRQH----------TTPPLPP-----------R 1036 Query: 1092 PQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTN 1151 P+RLPLSH+Q WF ++EG +N+P A+R EGP RHE LRT Sbjct: 1037 PERLPLSHAQQRLWFLDQVEGPSPAYNIPTAVRLEGPLDIPALAVALQDVTNRHEPLRTL 1096 Query: 1152 FDEHEGVPYQIVHPSRTV--QLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVLG 1209 E P+Q++ P +L + + + R F L+A+L G Sbjct: 1097 LAEDSEGPHQVILPPEAARPELTHSTVAPGDLAAALAEAARRPFDLAGEIPLKAHLFGCG 1156 Query: 1210 PDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTF 1269 PD H LLL+VHH D AS+E++ DL AY AR +AP ++ LP+Q+AD+ + +R+ Sbjct: 1157 PDDHTLLLLVHHTAGDGASVEVLVRDLAHAYGARRAGDAPHFEPLPLQYADHTLRRRHLL 1216 Query: 1270 ESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAER 1329 + T+LD+WRDALAGLP+++ + TD RP V +RGE + F+VP L +A+ Sbjct: 1217 DDPSDSTQLDHWRDALAGLPEQLELPTDHTRPAVPTRRGEAIAFTVPEHTHHTLRAMAQA 1276 Query: 1330 NGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGD 1389 +G T FM+ QAALA +L + G G DI LG+PVA R + T LVG F N +VLR D+SGD Sbjct: 1277 HGVTVFMVMQAALAALLSRHGAGHDIPLGTPVAGRSDDGTEDLVGFFVNTLVLRNDVSGD 1336 Query: 1390 PTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRG 1441 PT ++ R LDA A+Q++P ERLV+ L P R+LS +PLFQ M+ + G Sbjct: 1337 PTFAELVSRVRAANLDAYAYQDVPFERLVDVLKPERSLSWHPLFQIMIAYNG 1388 Score = 677 bits (1747), Expect = 0.0 Identities = 484/1440 (33%), Positives = 689/1440 (47%), Gaps = 120/1440 (8%) Query: 68 VAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQVFSDDVEVGWRREDLTRL 127 + + L G VD D LH V +V RH +LRT Y GE V + V W+ Sbjct: 2651 LTFDLTGPVDADHLHAVVESLVTRHDVLRTGYRQAQSGEWIAVVARQVHTPWQYIHTL-- 2708 Query: 128 PEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEVF 187 + ++L DE RPFD+T R T+ R ++ HH+ D S V Sbjct: 2709 -----DTDADTLTNDERWRPFDMTQGPLARFTLARINDTHFRFIVTYHHVILDGWSVAVL 2763 Query: 188 FGELSAAYND--------LPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXX 239 EL Y D +P + P F++ ++ A A W L Sbjct: 2764 IRELFTTYRDTALGRRPEVPYSPPRRDFMAWLAERDQTAAGQA----WRSALAGLAEPTV 2819 Query: 240 XX-GVSGANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASD 298 G G+ + L S + +AR + V+ AA+ +++ R G D Sbjct: 2820 LALGTEGSGVIPEVLEE--EISEELTSELVAWARGRGVTVASVVQAAWALVLGRLVGRDD 2877 Query: 299 FLVSVPVTERSGAAAGA---LGYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSV 355 + + V+ R AG +G F NT+ LR ++ +FV ++ HQ V Sbjct: 2878 VVFGLTVSGRPAEVAGVEDMVGLFVNTIPLRARMDPAESLGAFVERLQREQTELLEHQHV 2937 Query: 356 GIDRVVREANPERMGRDGM-------DLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAA 408 + V R A + + GM D L++ + GL +DG+ GA A Sbjct: 2938 RLAEVQRWAGHKELFDVGMVFENYPMDSLLQ---DSLFHGSGLQIDGIQ------GADAT 2988 Query: 409 HLPLSLTIALDPDDVSVEFEYQQQLSSV-LVDQMLVHYLQLVDKALAEPERPLSSLDILG 467 H L+L + P + Y+ + V ++ ++ ++ + E + P+S +D+LG Sbjct: 2989 HFALNLAVVPLPA-MRFRLGYRPDVFDAGRVRELWGWIVRALECVVCERDVPVSGVDVLG 3047 Query: 468 AGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEA-------ELTYSE 520 AGER+++L G + A D E +Y+E Sbjct: 3048 AGERETLLGWGAGAEPGVRALPGAGAGAGAGLVGLFEERVRTDPDAVAVRGAGVEWSYAE 3107 Query: 521 LHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERID 580 L+ RAN +ARW IG+G GPE +G+ M + + +LAV K+G YLP+DP +P ERID Sbjct: 3108 LNARANAVARWLIGRGVGPERGVGVVMDRGPDVVAMLLAVAKSGGFYLPVDPQWPTERID 3167 Query: 581 YLITDARPQTVIGRPELDVA----------------------ERAAADNSDLPLSDSDRL 618 +++ DA + L A E+AA D D+ +D +R+ Sbjct: 3168 WVLADAGIDLAVVGENLAAAVEAVRDCEVVDYAQIARETRLNEQAATDAGDV--TDGERV 3225 Query: 619 RPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDA 678 L GH YVIYTSGSTG PKGV V+H ++ +++ + A+ SS++FD Sbjct: 3226 SALLSGHPLYVIYTSGSTGLPKGVVVTHASVGAYLRRGRNAYRGAADGLGHVHSSLAFDL 3285 Query: 679 SLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQW 738 ++ +F L G + + GD+ A+ G+ Sbjct: 3286 TVTVLFTPLVSGGCVTL------GDLDDTAN-----GLGATFLKATPSHLPLLGQLDRVL 3334 Query: 739 RQLRHVPVGGEALPGEVADRFAGYFD-AELRNHYGPTEAVV-CSTHMVVTGSH-GARVVP 795 + +GGEAL + + + N YGPTE V C+ + + G VP Sbjct: 3335 APDATLLLGGEALTAGALHHWRTHHPHTTVINAYGPTELTVNCAEYRIPPGHCLPDGPVP 3394 Query: 796 IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF-NPGM 854 IG P + +VLD L P IGELY+ G LARGYLGRP LTA+RF+A PF +PG Sbjct: 3395 IGRPFTGHHLFVLDPALRLTPPDTIGELYVAGDGLARGYLGRPDLTAERFVACPFRSPGE 3454 Query: 855 RLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVAEETE 914 R+YRTGDL R G LEF+GRAD+QVKIRGFRIELGEVE+ + HP V + V E Sbjct: 3455 RMYRTGDLARWRSDGTLEFIGRADDQVKIRGFRIELGEVEAAVAAHPHVARAIAVVREDR 3514 Query: 915 AGPM-LAAYLVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPA 973 G L AY+ + + A +P YMVP A V+ +IP+T +GK+DR ALPA Sbjct: 3515 PGDQRLVAYVTGSDPSGLSSAVTDTVAGRLPAYMVPSAVVVLDQIPLTPNGKVDRAALPA 3574 Query: 974 PTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEF 1033 P + R P TA E +C++FA + G +VG ++ FF LGGHSLLA RL ++IR+ Sbjct: 3575 PGTASGTTSRAPGTAREEILCTLFADVLGLDQVGVDEDFFDLGGHSLLATRLTSRIRSAL 3634 Query: 1034 GVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQ 1093 G+DL VR +F APT L L ++ + R V R Sbjct: 3635 GIDLGVRALFKAPTVGRLDQLLQQQTTS--------------------LRAPLVARERTG 3674 Query: 1094 RLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNF- 1152 PLS +Q WF +++EG +N+P+ALR G RHE+LRT Sbjct: 3675 CEPLSFAQQRLWFLHQLEGPNAAYNIPMALRLTGRLDLTALEAALTDVIARHESLRTVIA 3734 Query: 1153 -DEHEGVPYQIVHPSRT---VQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLLVL 1208 D+ GV I+ T + L +D + + RH F + L+A + + Sbjct: 3735 QDDSGGVWQNILPTDDTRTHLTLDTMPVDAHTLQNRVDEAARHPFDLTTEIPLRATVFRV 3794 Query: 1209 GPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNT 1268 D HVLLL++HHI D S+ + DL AY RL+H+APQ L +Q+ADYA WQR+ Sbjct: 3795 TDDEHVLLLVLHHIAGDGWSMAPLAHDLSAAYTVRLEHHAPQLPALAVQYADYAAWQRDV 3854 Query: 1269 F--ESNWG---QTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRAAL 1323 E+N T+LDYW L GLP E+++ T R RP V + V+F+VP L Sbjct: 3855 LGTENNTSSQLSTQLDYWYSKLEGLPAELTLPTSRVRPAVASHACDRVEFTVPHDVHQGL 3914 Query: 1324 TQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVVLR 1383 T LA GAT FM+ QAALA +L +LG GTDI +G+P+A R + A L+GLF N +VLR Sbjct: 3915 TALARTQGATVFMVVQAALAALLSRLGAGTDIPIGTPIAGRTDQAMENLIGLFVNTLVLR 3974 Query: 1384 TDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFRGED 1443 TD+SGDPT +L R T LDA AHQ++P ERLVEA+NP R+L+R+PLFQ ML F D Sbjct: 3975 TDVSGDPTFAELLARVRTTALDAYAHQDIPFERLVEAINPERSLTRHPLFQVMLAFNNTD 4034 Score = 504 bits (1297), Expect = e-140 Identities = 371/1057 (35%), Positives = 517/1057 (48%), Gaps = 59/1057 (5%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS QRR+WFL ++ T NI VA RL G +D L A+ DV ARH LRT + Sbjct: 4746 ERLPLSFAQRRLWFLSKLEGPSATYNIPVAVRLTGALDVPALRAALGDVTARHESLRTVF 4805 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 D GEP Q+ E + ++T ++ AA G FD+T++ PLR T Sbjct: 4806 P-DDGGEPRQLVLPHAEPPFLTHEVT-------VGEVAEQAASATGYAFDITSDTPLRAT 4857 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----DLPINDPA-AQFLSVEVL 213 ++R +E VL++V+HHI D S +L AY D P P Q+ + Sbjct: 4858 LLRVSPEEHVLVVVIHHIAGDGWSMGPLVRDLVTAYRARTRGDAPEYTPLPVQYADYALW 4917 Query: 214 QNSAAP--------SVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQR--RVR-PLPAG 262 Q++ A + +GYW E L P R + R RVR LPAG Sbjct: 4918 QHAVAGDEDAPDGRTARRLGYWREMLAGLPEEHTLPA-DRPRPVRSSHRGGRVRFELPAG 4976 Query: 263 LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAG-ALGYFGN 321 + + AR A+ FMV+ AA L+ R D + PV R A +G+F N Sbjct: 4977 VHRSLLAVARDRRATLFMVVQAALAGLLSRLGAGDDIPIGTPVAGRGDEALDDVVGFFVN 5036 Query: 322 TLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRL 380 TL+LR +F V+ VR L FAHQ V +R+V P R + R + + Sbjct: 5037 TLVLRTNLAGDPSFADLVDRVRTADLDAFAHQDVPFERLVEALAPRRSLARHPLFQIWYT 5096 Query: 381 GFNMRKSAGGLALD---GVVVRQLGLGAVAAHLPLSLTIAL------DPDDVSVEFEYQQ 431 N + G AL+ G+ + LGA AA LS T D +SV +Y Sbjct: 5097 LTNADQDITGQALNALPGLTGDEYPLGASAAKFDLSFTFTEHRTPDGDAAGLSVLLDYSS 5156 Query: 432 QLSSVLVDQMLVHYLQLVDKALA-EPERPLSSLDILGAGERDSVLAQ-SHGELVEMPATT 489 L L H L ALA +P PL ++ +L ERD +L G +P + Sbjct: 5157 DLYDHGTAAALGHRLTGFFAALAADPTAPLGTVPLLTDDERDRILGDWGSGTHTPLPPRS 5216 Query: 490 MVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMAN 549 + + ++ E EL+Y EL R + AR +G G E ++ + + Sbjct: 5217 VAEQIVRRAALDPDAVAV--ITAEEELSYRELERLSGETARLLADRGIGRESLVAVALPR 5274 Query: 550 SIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVI------GRPELDVAERA 603 + + +L VL+ GAAYLP+D YP ER+ ++++DARP V+ GR +A Sbjct: 5275 TAGLVTTLLGVLRTGAAYLPLDTGYPAERLAHVLSDARPDLVLTHAGLAGRLPAGLAPTV 5334 Query: 604 AADNSDLPLSDSDRLRPLRPG--HLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWT 661 D P + + + P P HLAYVI+TSGSTGRPKGVA++ ++ + V Sbjct: 5335 LVDEPQPPAAAAPAV-PTSPSGDHLAYVIHTSGSTGRPKGVAIAESSLRAFLADAVRRHD 5393 Query: 662 MTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXX 721 +T DR L ++V FD + ++F L GA +++ DA D + + L +R VTV Sbjct: 5394 LTPHDRLLAVTTVGFDIAGLELFAPLLAGAAIVLADEDAVRDPASITSLCARHHVTVVQA 5453 Query: 722 XXXXXXXXXXXXXXXQWRQLRHVP--VGGEALPGEVADRFAGYFDAELRNHYGPTEAVVC 779 +L HV VGGE LP ++A R A + N YGPTEA + Sbjct: 5454 TPSWWRAMLDGAPADAAARLEHVRILVGGEPLPADLA-RVLTATGAAVTNVYGPTEATIW 5512 Query: 780 STHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPT 839 +T +T R IG P N ++LD L PVP V GE+++ GS LARGYL RP Sbjct: 5513 ATAAPLTAGDD-RTPGIGTPLDNWRVHILDAALGPVPPGVPGEIHIAGSGLARGYLRRPD 5571 Query: 840 LTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITT 899 LTA+RF+A+PF PG R+YRTGDL R G LE +GR D+QVK+RGFRIELG+VE+ + Sbjct: 5572 LTAERFVANPFAPGERMYRTGDLGRFRPDGTLEHLGRVDDQVKVRGFRIELGDVEAALAR 5631 Query: 900 HPAV-RHCLVVAEETEAGPMLAAYLV--PAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIP 956 HP V R V + L AY+V P D E+R +P+YMVP A + Sbjct: 5632 HPDVGRAAAAVRPDHRGQGRLVAYVVPRPGTRGPDAGELRETVRELLPDYMVPSAQVTLT 5691 Query: 957 EIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLG 1016 +P T +GKLDR ALPAP T R P T E+ + +FA + G VGA+ FF LG Sbjct: 5692 TLPHTPNGKLDRAALPAPV-FGTPAGRAPATREEKILAGLFADILGLPDVGADSGFFDLG 5750 Query: 1017 GHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAA 1053 G S+L+ +LV++ R E G+ +TVR +F+ T LAA Sbjct: 5751 GDSVLSIQLVSRARRE-GLHITVRDVFEHGTVGALAA 5786 Score = 486 bits (1251), Expect = e-134 Identities = 368/1065 (34%), Positives = 531/1065 (49%), Gaps = 77/1065 (7%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+R+WFL ++ NI A RL G +D L A+ DV RH LRT Sbjct: 1038 ERLPLSHAQQRLWFLDQVEGPSPAYNIPTAVRLEGPLDIPALAVALQDVTNRHEPLRTLL 1097 Query: 100 GVDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 D+EG P+QV R +LT A + + + A+ RPFDL E+PL+ Sbjct: 1098 AEDSEG-PHQVILPPEAA---RPELTHSTVAPGD--LAAALAEAARRPFDLAGEIPLKAH 1151 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----DLPINDPAA-QFLSVEVL 213 + D+ LLL+VHH D S EV +L+ AY D P +P Q+ + Sbjct: 1152 LFGCGPDDHTLLLLVHHTAGDGASVEVLVRDLAHAYGARRAGDAPHFEPLPLQYADHTLR 1211 Query: 214 QNSAAPSVAD---VGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLPAGLFSRVE 268 + +D + +W + L A P RR + +P + Sbjct: 1212 RRHLLDDPSDSTQLDHWRDALAGLPEQLELPTDHTRPAVPTRRGEAIAFTVPEHTHHTLR 1271 Query: 269 DFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNTLLLRI 327 A+ + FMV+ AA L+ R+ D + PV RS L G+F NTL+LR Sbjct: 1272 AMAQAHGVTVFMVMQAALAALLSRHGAGHDIPLGTPVAGRSDDGTEDLVGFFVNTLVLRN 1331 Query: 328 TTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFN---M 384 TF V+ VR L +A+Q V +R+V PER + + +N Sbjct: 1332 DVSGDPTFAELVSRVRAANLDAYAYQDVPFERLVDVLKPERSLSWHPLFQIMIAYNGPAT 1391 Query: 385 RKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDDVSVE--FEYQQQL-SSVLVDQM 441 +A G G+ R + + LS + D + ++ E+ L + + +++ Sbjct: 1392 NDTADGSRFAGLTSRVHAVHTGMSKFDLSFFLTEHADGLGIDGALEFSTDLFTRITAERL 1451 Query: 442 LVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXX 501 + YL ++++A P+RP+SS ++LG ER ++LAQ + P T++ Sbjct: 1452 VQRYLTVLEQAAGAPDRPISSYELLGDDER-ALLAQWNDTAHPTPPGTVLDLLESRAART 1510 Query: 502 XXXXXXXXVSDEAELTYSELHRRANRLARWFI-GQGFGPEDIIGLRMANSIEFIVAMLAV 560 V ++ LTY++LH RANRLAR I G GPE ++ + + S E +VA+LAV Sbjct: 1511 PDRPAV--VENDHVLTYADLHTRANRLARHLITAHGVGPERLVAVALPRSAELLVALLAV 1568 Query: 561 LKAGAAYLPIDPAYPDERIDYLITDARPQTVI-------GRPELDVAE---------RAA 604 LK GAAY+P+D +P ER ++ D RP ++ P D+ + A Sbjct: 1569 LKTGAAYVPLDLTHPAERTAVVLDDCRPAVILTDAGAARELPRRDIPQLRLDEPEVHAAI 1628 Query: 605 ADNSDLPLSDSDR--LRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTM 662 A+ P++D DR + P+ H+AYVIYTSGSTGRPKGVAV H ++A+ V+ V + Sbjct: 1629 AEQPGGPVTDRDRTCVTPVSGEHVAYVIYTSGSTGRPKGVAVEHRSLADFVRYSVTAYP- 1687 Query: 663 TAEDRWLQFSSVSFDASLADIFVTLFLGAQLIV--------PKPDAFGDISYVADLISRR 714 A D L S V+FD ++ +F L +G + V P A G ++V S Sbjct: 1688 GAFDVTLLHSPVTFDLTVTSLFPPLVVGGAIHVADLTEACPPSLAAAGGPTFVKATPSHL 1747 Query: 715 GVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRF-AGYFDAELRNHYGP 773 + + + VGGE L G D++ AG +A + N YGP Sbjct: 1748 PLLTHEATWA--------------ASAKVLLVGGEQLLGRELDKWRAGSPEAVVFNDYGP 1793 Query: 774 TEAVV-CSTHMVVTGSH-GARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLA 831 TEA V C + G GA V IG P RN +VLD L VP V+GEL++ G LA Sbjct: 1794 TEATVNCVDFRIDPGQPIGAGPVAIGRPLRNTRVFVLDGGLRAVPVGVVGELHVAGEGLA 1853 Query: 832 RGYLGRPTLTAQRFIADPF-NPGMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIEL 890 RGYLG+P LTA+RF+A PF + G R+YRTGDLVR G LEFVGR D+QVK+RGFRIEL Sbjct: 1854 RGYLGQPGLTAERFVACPFGDAGERMYRTGDLVRWRADGMLEFVGRVDDQVKVRGFRIEL 1913 Query: 891 GEVESVITTHPAVRHCLVVAEETEAGP-MLAAYLVPAAAQVD-LEEIRAHTAAA-VPEYM 947 GEVE+ + P V +VV E G L AY+ A + + L + TAA +P YM Sbjct: 1914 GEVEAAVAACPGVDRSVVVVREDRPGDRRLVAYVTAAGDEAEGLAPLIVETAAGRLPGYM 1973 Query: 948 VPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVG 1007 VP A V+ EIP+T +GK+DR ALPAP +R + E +C++FA++ G +RVG Sbjct: 1974 VPSAVVVLDEIPLTPNGKVDRAALPAPRVAPAAEFRVTGSPREEALCALFAEVLGVERVG 2033 Query: 1008 AEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA 1052 +D FF LGG S+L+ +LVA+ R G++++VR +F+ T LA Sbjct: 2034 VDDGFFDLGGDSILSIQLVARAR-RAGLEVSVRDVFEHRTVRALA 2077 Score = 50.4 bits (119), Expect = 0.002 Identities = 28/77 (36%), Positives = 40/77 (51%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E L A+ E+L + + D+ +F LGGDSI++I+ A+A GL VFEH T+ Sbjct: 2016 EEALCALFAEVLGVERVGVDDGFFDLGGDSILSIQLVARARRAGLEVSVRDVFEHRTVRA 2075 Query: 1620 LAAAVDAANGEPVVEAD 1636 LA V + G D Sbjct: 2076 LAGVVRESGGVAAAVVD 2092 Score = 45.8 bits (107), Expect = 0.052 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 3/77 (3%) Query: 1560 ERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTIAE 1619 E+ L + ++L + + D +F LGGDS+++I+ ++A GL VFEH T+ Sbjct: 5724 EKILAGLFADILGLPDVGADSGFFDLGGDSVLSIQLVSRARREGLHITVRDVFEHGTVGA 5783 Query: 1620 LAAAVDAANGEPVVEAD 1636 LAAA A P +AD Sbjct: 5784 LAAAALPA---PADDAD 5797 >tr|B1MAQ8|B1MAQ8_MYCA9 Tax_Id=561007 SubName: Full=Probable peptide synthetase MbtE;[Mycobacterium abscessus] Length = 1458 Score = 761 bits (1964), Expect = 0.0 Identities = 497/1353 (36%), Positives = 691/1353 (51%), Gaps = 80/1353 (5%) Query: 44 LSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDT 103 LS GQ R+WF + P V +N+C +YRL G +D D+L AV VV RHA LRTT Sbjct: 29 LSAGQHRIWFAHGVTP--VLMNLCRSYRLHGELDVDKLRAAVAAVVLRHAALRTTVHAGA 86 Query: 104 EGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRT 163 +G P V D++ W D+T L E ++ LA E+G FDL E PLR+TVIRT Sbjct: 87 DGHPVAVLHSDLQARWIEHDVTDLGGTAQELRLAVLAQREYGTAFDLATEAPLRVTVIRT 146 Query: 164 RADELVLLLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVAD 223 + E V+L+V H I WDD+SW+VF +L+AAY I++P + P A Sbjct: 147 GSAEYVMLVVAHRIGWDDESWQVFLADLTAAYVHGGISEPLSS------APKQGGPGDAA 200 Query: 224 VGYWAETLRXXXXXXXXXGVSGANPCR--RAQRRVRPLPAGLFSRVEDFARKCSASPFMV 281 V YW E L G +GA +A R L + +VE AR ++P V Sbjct: 201 VDYWREELSNPAEPLELPGPNGAVVPTDWKAARCTAHLSVSVMEQVERLARDSGSTPHAV 260 Query: 282 LLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNE 341 LLAAY VL+ RYT A+DF+V+ PV A G +G+FGN L LR+ R+ ++F + Sbjct: 261 LLAAYSVLLHRYTHANDFIVASPVPALDPHARGRIGHFGNVLPLRMRPRADESFKDLLAR 320 Query: 342 VRETCLAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRKSAGGLALD-GVVVRQ 400 VR T L G AHQ V +DRVV R+GF+M + L G+ + Sbjct: 321 VRRTTLDGMAHQGVSLDRVVP----------------RVGFSMATDSAELFCPPGIRCEK 364 Query: 401 LGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERP 459 + A++PL LT+ + V EY L + Q+L H+ +++ LA+P+R Sbjct: 365 AAFESHVAYVPLGLTVEVKSGGADVVAEYLVTVLDERMATQLLRHFANVLEAVLADPDRM 424 Query: 460 LSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYS 519 + ++D++ E + A S GE E P T+ + V + +Y Sbjct: 425 VGAVDLMDDREAQWLWAASSGERFEAPPATLGELVAERAGAQPDAVAV--VYEGRHYSYR 482 Query: 520 ELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERI 579 E + ANRLA W I QG G ED + + + S + I+ LA+ KAGA YLPIDP YP +RI Sbjct: 483 ETNDLANRLAHWIIEQGIGTEDHVAVLLDKSPDLIITALAIAKAGAVYLPIDPEYPPDRI 542 Query: 580 DYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRP 639 +++ DA+P+ VI P + + A + P+ DSDR+RPL P + AY+IYTSGSTG P Sbjct: 543 AHILADAQPRLVIREPVTGLDQFDARE----PV-DSDRVRPLTPDNAAYLIYTSGSTGMP 597 Query: 640 KGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPD 699 KGV V+H + E+ F AE+ + DR LQ S SFD S+ +IF L G +L++P+P Sbjct: 598 KGVTVTHRPLTEYFNWFRAEYRVGGSDRVLQVGSPSFDVSIGEIFGILSCGGRLVIPRPG 657 Query: 700 AFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRF 759 D++Y+ L++ VT QW+ LR VPVGGEALPG VAD+F Sbjct: 658 GLTDVAYLTALLNSEAVTSMHMVPSLLGLILSLPGVTQWKSLRRVPVGGEALPGPVADKF 717 Query: 760 AGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQV 819 FDA L N YGPTEA++ ++ V G G R VPIG P N ++LDE L PVP Sbjct: 718 HATFDASLHNFYGPTEAIINASRYKVRGIQGTRTVPIGTPKINTQIHILDETLRPVPVGA 777 Query: 820 IGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADE 879 IGE+Y+ G+ LARGY P LTAQRFIADPF PG R+YR+GDL RRN G++EFVGRADE Sbjct: 778 IGEIYIAGTHLARGYHRAPALTAQRFIADPFTPGQRMYRSGDLARRNAGGDVEFVGRADE 837 Query: 880 QVKIRGFRIELGEVESVITTHPAVRHCLVVAEE-TEAGPMLAAYLVPAAAQ-VDLEEIRA 937 QVKIRGFR+ELGE+ S I P+V LVV +E G L AYL P VD++ IR+ Sbjct: 838 QVKIRGFRVELGEISSAIEVDPSVSQALVVVDELPHLGKRLVAYLTPIGGHVVDIDRIRS 897 Query: 938 HTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIF 997 +AA+P+YM+P A+ V+ EIP+T GK+DR ALPAP RE +T T+R + +F Sbjct: 898 RISAALPDYMIPAAYVVLDEIPITPHGKIDRDALPAPDSGTVTERREAQTPTQRAVSVLF 957 Query: 998 AQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVE 1057 AQ+ G VG +DSF LGGHSLLA++L A I +E+GV + +R I T A L A L++ Sbjct: 958 AQVLGTAVVGIDDSFESLGGHSLLASKLSATILSEYGVRIDIREILRRGTVASL-AELID 1016 Query: 1058 RFRNDFELDLDNL-AADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREE 1116 + +D+ + +PL LP HS ++Y G Sbjct: 1017 QHMGSTADSVDSAPEGEPIPL-----------------LPGGHS----LYEY---GNPRR 1052 Query: 1117 FNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAI 1176 + R HEAL + D +V +R V + Sbjct: 1053 LAVTCVFRLHDGVNRAALEQLLGAVVGEHEALHSRLDRES---MTLVPRARPALRFVEIV 1109 Query: 1177 DQDEFDDVSTQLRRHV--FTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFD 1234 D + ++ R V PE G +L A L + VL+L VHH+ +D S ++ Sbjct: 1110 AADPSVAAAAEIARAVDRLDPEQGWMLSAVWLHPDNEPGVLILAVHHLAADPISWRVIMS 1169 Query: 1235 DLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISV 1294 +L ++A + H P D+ W + L +W L G D+ + Sbjct: 1170 ELEARWQA-VAHQVPS-DVDQTSIG-LRQWANSLAAEARDVNSLPFWVAQLDG--DDPDI 1224 Query: 1295 ATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTD 1354 + R P R V + AA +++L +G L AA+A + + G Sbjct: 1225 GSRRIAPET--DRDSEVAITAEAA-PVGVSELLLNSGVPMERLLAAAVARTIAQWRRGRG 1281 Query: 1355 IALGSPVAARVEP----ATAQLVGLFANVVVLR 1383 A P+ A P +TA VG + V LR Sbjct: 1282 QATVEPLLAIQIPGRGESTAATVGPLSTVYPLR 1314 Score = 81.6 bits (200), Expect = 9e-13 Identities = 90/364 (24%), Positives = 143/364 (39%), Gaps = 60/364 (16%) Query: 1095 LPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEALRTNFDE 1154 +PLS Q WF + + N+ + R G RH ALRT Sbjct: 27 MPLSAGQHRIWFAHGVTPVL--MNLCRSYRLHGELDVDKLRAAVAAVVLRHAALRTTVHA 84 Query: 1155 H-EGVPYQIVHPSRTVQLAVRAIDQDEFD--DVSTQLRRHV---------FTPESGPLLQ 1202 +G P ++H L R I+ D D + +LR V F + L+ Sbjct: 85 GADGHPVAVLHSD----LQARWIEHDVTDLGGTAQELRLAVLAQREYGTAFDLATEAPLR 140 Query: 1203 ANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYR----ARLQHNAPQWDILPIQF 1258 ++ G +V+L++ H I D S ++ DL AY + +AP+ Sbjct: 141 VTVIRTGSAEYVMLVVAHRIGWDDESWQVFLADLTAAYVHGGISEPLSSAPK-------- 192 Query: 1259 ADYAVWQRNTFESNWGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAA 1318 + G +DYWR+ L+ + + + G G VV AA Sbjct: 193 -----------QGGPGDAAVDYWREELSNPAEPLELP---------GPNGAVVPTDWKAA 232 Query: 1319 RRAA---------LTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPAT 1369 R A + +LA +G+T + AA +V+LH+ D + SPV A ++P Sbjct: 233 RCTAHLSVSVMEQVERLARDSGSTPHAVLLAAYSVLLHRYTHANDFIVASPVPA-LDPHA 291 Query: 1370 AQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSR 1429 +G F NV+ LR D + + +L R T LD +AHQ + ++R+V + A Sbjct: 292 RGRIGHFGNVLPLRMRPRADESFKDLLARVRRTTLDGMAHQGVSLDRVVPRVGFSMATDS 351 Query: 1430 NPLF 1433 LF Sbjct: 352 AELF 355 >tr|C3JNH4|C3JNH4_RHOER Tax_Id=596309 SubName: Full=Amino acid adenylation domain protein; Flags: Fragment;[Rhodococcus erythropolis SK121] Length = 2100 Score = 759 bits (1959), Expect = 0.0 Identities = 521/1459 (35%), Positives = 726/1459 (49%), Gaps = 101/1459 (6%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 ER LS Q+RMWFL D NI + RL+G VD L AV+DVVARH +LRT Y Sbjct: 682 ERVPLSLAQQRMWFLSRFDAVSGVNNIPIVLRLSGTVDIAALGAAVSDVVARHEVLRTVY 741 Query: 100 GVDTEGEPYQ----VFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELP 155 + EG +Q V +VEV P+ E + + A FD+T+E+P Sbjct: 742 P-EFEGVGFQRVLSVDEFEVEVS---------PDLVSEADLLKVLAPVVTVGFDVTSEVP 791 Query: 156 LRITVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----NDLPINDP-AAQFLS 209 LR+ + +T E VL LV+HHI D S ++S AY +P P A Q+ Sbjct: 792 LRVRLFQTGPSEFVLALVIHHIAADGVSLGPLVRDVSVAYVARAGGQVPQWAPLAVQYAD 851 Query: 210 VEVLQNSAAPSVAD--------VGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLPA 261 + Q S D +GYW L R RPL A Sbjct: 852 FALWQREVLGSEGDPSSLMSEQLGYWTSVLAGLPERIDLPA-----------DRQRPLVA 900 Query: 262 G-------------LFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTER 308 L +E A S S FMV+ AA VL+ R +G+ D +V P+ R Sbjct: 901 SNHGASYQFSVDERLHRALEQLALDRSVSLFMVVHAALVVLLARLSGSDDVVVGSPIAGR 960 Query: 309 SGAAAGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPE 367 L G F NTL+LR S ++F+ + VRE L F ++ V +R+V +P Sbjct: 961 GEQELDDLIGMFVNTLVLRTEVDSSESFSKLLGRVREVDLGAFGNEDVPFERLVEVLDPA 1020 Query: 368 RMGRDGMDLLVRLGFNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIA-LDPDDVSVE 426 R V L F + G + L G+ + G A L LT+ ++ D V V Sbjct: 1021 RSQAHHPLFQVALFFQ-NMAQGDVELPGLSIAGFDAGVEIAKFDLQLTVTPVEEDGVGVG 1079 Query: 427 FEYQQQLSSVLVDQMLV-----HYLQLVDKALAEPERPLSSLDILGAGERDSVLAQSHGE 481 ++ L D+ V +++++ +AEP+ + +++LG ER VL + Sbjct: 1080 MPMSLTYATDLFDESTVVSFAERLVRVLEAMVAEPDSVVGDVELLGEDERSQVLVAVNDT 1139 Query: 482 LVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPED 541 + E+ A ++ V + LTY+E R NRLAR+ + G GPE Sbjct: 1140 VHELTAGALL-LDGFVAQVAATPDAVAVVFEGQSLTYAEFGSRVNRLARYLVSVGVGPES 1198 Query: 542 IIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRP------ 595 ++ L M S++ +V M AV+ AG AY+P+DP +P ER +++ A P V+ Sbjct: 1199 LVALAMRRSVDLVVGMYAVVAAGGAYVPLDPDHPVERNGHILGTAAPVCVLSTAGDGVVL 1258 Query: 596 --ELDVA---ERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIA 650 E DV E + SD P+SD+DR+ PLR + AYVI+TSGSTG+PKGVAVSH AI Sbjct: 1259 PGEFDVVLIDELDVSGFSDAPVSDADRVAPLRGSNAAYVIFTSGSTGKPKGVAVSHAAIV 1318 Query: 651 EHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADL 710 + + +T D +LQ ++ +FD SL F+ L +GA+L+V D D Y+A + Sbjct: 1319 NQMAWMQGRYVLTGADVYLQKTATTFDVSLWGFFLPLAVGARLVVATHDGHRDPGYLASV 1378 Query: 711 ISRRGVTVXXXXXXXXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNH 770 I+ +GVTV LR V V GEALP + F A + N Sbjct: 1379 IADQGVTVTDFVPTMLSVFAGEVSAGHLVSLRDVFVIGEALPAQTVRDFGVVSGARVHNL 1438 Query: 771 YGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQL 830 YGPTEA V T VT + VV IGVP N +VLD +L PVP V GELYL G QL Sbjct: 1439 YGPTEAAVSITFADVTCAVDGGVVSIGVPQWNSQVFVLDSRLRPVPVGVAGELYLAGDQL 1498 Query: 831 ARGYLGRPTLTAQRFIADPFNP-GMRLYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIE 889 ARGY+ RP L+A RF+A+P+ G R+YRTGDLVR GELE++GR D QVK RG RIE Sbjct: 1499 ARGYVSRPDLSADRFVANPYGGVGSRMYRTGDLVRWGVSGELEYIGRTDFQVKFRGQRIE 1558 Query: 890 LGEVESVITTHPAVRHCLVVAEETEAGPMLAAYLVPAA-AQVDLEEIRAHTAAAVPEYMV 948 LGE+ES + +V V T+ G L Y+VPA+ A VD+ + A +P YMV Sbjct: 1559 LGEIESALVADMSVSVSSVAVVSTKTGDQLVGYVVPASGAVVDIAALVDSLGAVLPSYMV 1618 Query: 949 PGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGA 1008 P V+ P+ SGKLDR+ LP P +R P TA E + S FA++ G RVG Sbjct: 1619 PSQIMVLDAFPLNASGKLDRKLLPEPV-FEKAVFRAPVTAVEEIVASAFAEVLGVDRVGL 1677 Query: 1009 EDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLD 1068 +D FF LGG+SL+A R+ A++ + VR +F+A + LAAR+ + Sbjct: 1678 DDDFFALGGNSLIATRVAARLGQALDAQVPVRVLFEASSVELLAARVESEVGSG------ 1731 Query: 1069 NLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGP 1128 AR RP+R+PLS +Q WF R E +N+P+A+R G Sbjct: 1732 -------------ARAALTAMVRPERIPLSLAQQRMWFLNRFEPESTAYNLPVAIRLSGL 1778 Query: 1129 XXXXXXXXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDEFDDVSTQL 1188 RHE LRT + E +GV YQ + V+L + + E D +S + Sbjct: 1779 LDVAALQAAVSDVVARHEVLRTVYPEVDGVGYQQIVSVDRVELDLTPVPVSEADVMSAVV 1838 Query: 1189 --RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQH 1246 F ++A + V+ PD +VL+ +VHHI +D +S+ + DL+VAY AR Sbjct: 1839 GFMSSGFDVTVQVPVRARVFVVAPDEYVLVFVVHHISADGSSMGPMTRDLMVAYMARSAD 1898 Query: 1247 NAPQWDILPIQFADYAVWQRNTFESNWGQTEL-----DYWRDALAGLPDEISVATDRARP 1301 P W L +Q+ADYA+WQR S L ++W ALAGLPD++ + DR RP Sbjct: 1899 AVPSWAPLAVQYADYALWQREVLGSEDDAASLISRQVEFWSRALAGLPDQLVLPWDRPRP 1958 Query: 1302 RVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPV 1361 V G V + A L +A++N +T FM+ AALAVVL +L G DI +G+P+ Sbjct: 1959 AVQAFDGGQVPVVIGADLHRRLVDVAQQNNSTLFMVVHAALAVVLARLSGTEDITVGTPI 2018 Query: 1362 AARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEAL 1421 A R E A LVG+F N +VLRT + + +L SR+ L A AH ++P ERLVE L Sbjct: 2019 AGRGERALDDLVGMFVNTLVLRTSVDAGVSFTDLLSRSREADLAAFAHADVPFERLVEVL 2078 Query: 1422 NPPRALSRNPLFQNMLNFR 1440 NP R+ + +PLFQ L+F+ Sbjct: 2079 NPVRSTAYHPLFQVGLSFQ 2097 Score = 539 bits (1389), Expect = e-150 Identities = 348/959 (36%), Positives = 511/959 (53%), Gaps = 70/959 (7%) Query: 516 LTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYP 575 L+YSEL ++RLAR I G GPED + + + SIE ++A+ AV K+GAA++P+DP YP Sbjct: 114 LSYSELDEWSSRLARVLIADGVGPEDRVAVSVPRSIESVLALWAVAKSGAAFVPVDPNYP 173 Query: 576 DERIDYLITDAR--------------PQTV----IGRPELDVAERAAADNSDLPLSDSDR 617 +R+ Y+I D+ P +V I P++ +++ ++ S P++ SDR Sbjct: 174 ADRVAYMIEDSGVSVGLTVEEVVSDLPSSVDWKSIDSPKV---KQSLSEVSRDPVAYSDR 230 Query: 618 LRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFD 677 + LR H AYVIYTSGSTGRPKGV V+H + + V + A+ R L F++ SFD Sbjct: 231 VSTLRVEHPAYVIYTSGSTGRPKGVVVTHGGLGNLLSEQVDKLGAKAQSRVLHFATPSFD 290 Query: 678 ASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXXXQ 737 SL ++ +T+ G+ +++ P +G +A+L+ VT Sbjct: 291 TSLFELLLTIGSGSTMVIVPPSIYGG-EELAELLEAERVT----HVVGTPSMLASVDPTN 345 Query: 738 WRQLRHVPVGGEALPGEVADRFA---GYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVV 794 + VGGE P E+ ++ +F+A YGPTE + T++ + G R V Sbjct: 346 LNSVEAAIVGGEVCPPELVAKWGRGRAFFNA-----YGPTETTII-TNISPNLAPGDR-V 398 Query: 795 PIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFN-PG 853 IG P + V + VLD +L PVP GELYL G Q+ARGY +TA RF+A+PF G Sbjct: 399 SIGGPIQGVSSLVLDSRLLPVPVGSTGELYLAGPQVARGYHNLRGMTADRFVANPFGAQG 458 Query: 854 MRLYRTGDLVR---RNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLVVA 910 R+YRTGDLVR +LE+VGR+D Q+KIRGFR+ELGE+++V+ HP+V + Sbjct: 459 DRMYRTGDLVRWVADAGARDLEYVGRSDSQLKIRGFRVELGEIDAVLAKHPSVEFVATIG 518 Query: 911 EETEAGP-MLAAYLVP-AAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDR 968 + + G L AY++P ++ D+ E+ + +P +MVP + VI EIP+T GKLD Sbjct: 519 RKLDNGEHALVAYVLPLTGSEFDVSELIDNCRRELPRHMVPASVMVIDEIPLTPVGKLDV 578 Query: 969 RALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQ 1028 ALP P +R +REP + +E + +F +L G ++VGA+D FF LGG+SL+AA+L + Sbjct: 579 AALPDPV-FESRAFREPSSESEMLVAGVFGELLGLEQVGADDDFFELGGNSLIAAKLAGR 637 Query: 1029 IRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRARPGFVK 1088 + A F V + V+T+F++ T A LA+ L R R Sbjct: 638 LSAAFDVRVQVKTLFESSTVASLASVL--------------------RASAGRVRVPLSA 677 Query: 1089 SARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXXXRHEAL 1148 RP+R+PLS +Q WF R + N+P+ LR G RHE L Sbjct: 678 QTRPERVPLSLAQQRMWFLSRFDAVSGVNNIPIVLRLSGTVDIAALGAAVSDVVARHEVL 737 Query: 1149 RTNFDEHEGVPYQIV--HPSRTVQLAVRAIDQDEFDDVSTQLRRHVFTPESGPLLQANLL 1206 RT + E EGV +Q V V+++ + + + V + F S L+ L Sbjct: 738 RTVYPEFEGVGFQRVLSVDEFEVEVSPDLVSEADLLKVLAPVVTVGFDVTSEVPLRVRLF 797 Query: 1207 VLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQR 1266 GP VL L++HHI +D SL + D+ VAY AR PQW L +Q+AD+A+WQR Sbjct: 798 QTGPSEFVLALVIHHIAADGVSLGPLVRDVSVAYVARAGGQVPQWAPLAVQYADFALWQR 857 Query: 1267 NTFESNWGQT-----ELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAARRA 1321 S + +L YW LAGLP+ I + DR RP V G QFSV Sbjct: 858 EVLGSEGDPSSLMSEQLGYWTSVLAGLPERIDLPADRQRPLVASNHGASYQFSVDERLHR 917 Query: 1322 ALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLVGLFANVVV 1381 AL QLA + FM+ AAL V+L +L G D+ +GSP+A R E L+G+F N +V Sbjct: 918 ALEQLALDRSVSLFMVVHAALVVLLARLSGSDDVVVGSPIAGRGEQELDDLIGMFVNTLV 977 Query: 1382 LRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLFQNMLNFR 1440 LRT++ + +L R+ L A ++++P ERLVE L+P R+ + +PLFQ L F+ Sbjct: 978 LRTEVDSSESFSKLLGRVREVDLGAFGNEDVPFERLVEVLDPARSQAHHPLFQVALFFQ 1036 Score = 44.3 bits (103), Expect = 0.15 Identities = 27/91 (29%), Positives = 47/91 (51%), Gaps = 1/91 (1%) Query: 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQ-AGALGLPFPPAMVFEHMT 1616 E+E + + ELL + + D+++F LGG+S+IA K + + + A + +FE T Sbjct: 597 ESEMLVAGVFGELLGLEQVGADDDFFELGGNSLIAAKLAGRLSAAFDVRVQVKTLFESST 656 Query: 1617 IAELAAAVDAANGEPVVEADPPPAQEYTPMS 1647 +A LA+ + A+ G V E P+S Sbjct: 657 VASLASVLRASAGRVRVPLSAQTRPERVPLS 687 Score = 43.5 bits (101), Expect = 0.26 Identities = 25/62 (40%), Positives = 41/62 (66%), Gaps = 4/62 (6%) Query: 1572 EITGIDR---DENYFALGGDSIIAIKWSAQAG-ALGLPFPPAMVFEHMTIAELAAAVDAA 1627 E+ G+DR D+++FALGG+S+IA + +A+ G AL P ++FE ++ LAA V++ Sbjct: 1668 EVLGVDRVGLDDDFFALGGNSLIATRVAARLGQALDAQVPVRVLFEASSVELLAARVESE 1727 Query: 1628 NG 1629 G Sbjct: 1728 VG 1729 >tr|Q5Z1X9|Q5Z1X9_NOCFA Tax_Id=37329 SubName: Full=Putative non-ribosomal peptide synthetase;[Nocardia farcinica] Length = 2403 Score = 758 bits (1957), Expect = 0.0 Identities = 536/1506 (35%), Positives = 759/1506 (50%), Gaps = 81/1506 (5%) Query: 41 RYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYG 100 R LS Q+RMWFL DPD NI VA RL G + D L AV D+V RH +LRT Y Sbjct: 601 RVPLSYAQQRMWFLNRFDPDSGVNNIPVAVRLTGALHVDALRAAVRDLVERHEVLRTVYP 660 Query: 101 -VDTEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRIT 159 VD +G + DD V + +T A E + G FD+T P+R+ Sbjct: 661 EVDGDGVQEVLPLDDPRVVPALDVVT----ATEEELFAQVGTVALGG-FDVTVAPPVRLR 715 Query: 160 VIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----DLPINDP-AAQFLSVEVL 213 + +E VLL VVHHI D S +L +AY+ D P P A Q+ + Sbjct: 716 LFALGPEEHVLLCVVHHIAGDGFSMGPLTRDLMSAYSVRVNGDRPRWAPLAVQYADYALW 775 Query: 214 QNSAAPSVAD--------VGYWAETLRXXXXXXXXXG--VSGANPCRRAQRRVRPLPAGL 263 Q + D + +W E L A RA L A L Sbjct: 776 QRETLGAEDDPDSLLAQQIAFWREQLAGLPEQLDLPADRPRPAVMSNRAAAYSFELDAEL 835 Query: 264 FSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-GYFGNT 322 + ++ A++ +++ F V+ AA+ VL+ R +G +D V V R A L G F NT Sbjct: 836 HAALDSLAQQHNSTLFFVMHAAFSVLLARLSGTTDIAVGTAVAGRGDEALDDLVGMFVNT 895 Query: 323 LLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLG 381 L+LR +F + +VR+T +A FAH + +R+V +P R MGR + ++ Sbjct: 896 LVLRSDVDPDASFAELLAKVRQTDVAAFAHADLPFERLVELLDPARSMGRHPLFQVMLTF 955 Query: 382 FNMRKSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD-----VSVEFEYQQQLSSV 436 NM + L L G+ L LGA A L LT+ D ++ F Y L Sbjct: 956 QNMAHTE--LRLPGLTAAALELGAPLAKFDLELTLVPRETDGAPAGMAASFIYATDLFDE 1013 Query: 437 LVDQMLVHYLQLVDKALAEP-ERPLSSLDILGAGERDSVLAQSHGELVEMPATTMVKXXX 495 L+ V A+ E R + ++D+L GER +L + +PA ++ Sbjct: 1014 STMAAFAERLRRVLTAVVEDARRSVGAIDLLEPGERQRILLDWNDTAHPLPARLLLDGYR 1073 Query: 496 XXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIV 555 + AELTY E R NRLAR I +G G E ++GL + S++ +V Sbjct: 1074 RAVAAHADSVALSY--EGAELTYREFDERVNRLARLLIARGVGAESLVGLAVRRSLDLVV 1131 Query: 556 AMLAVLKAGAAYLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAA-----DNSDL 610 M A++ AG AY+P+DP +P ERI +++ A P V+ A A A D DL Sbjct: 1132 GMYAIVTAGGAYVPLDPDHPAERIAHILDTADPVCVLSTSADAAAVPAGAEVLHVDTVDL 1191 Query: 611 ------PLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTA 664 P+ ++ +RP+RP + AYVI+TSGSTGRPKGVAVSH AI ++ ++E+ M Sbjct: 1192 SGYSAAPVEAAELVRPVRPDNPAYVIFTSGSTGRPKGVAVSHGAIDNQIEWMLSEYPMGP 1251 Query: 665 EDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXX 724 D +LQ ++ +FD SL F+ L GA+L+V D D +Y+A+ I+ + VTV Sbjct: 1252 GDVYLQKTATTFDVSLWGYFMPLRAGAKLVVATHDGHRDPAYIAETIAAQRVTVTDFVPS 1311 Query: 725 XXXXXXXXXXXXQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMV 784 LR + V GEALP E DA + N YGPTEA V T+ Sbjct: 1312 MLTVFATHTAPGSVPTLRDIFVIGEALPPETVAAVRAMSDAAVHNLYGPTEAAVSVTYWP 1371 Query: 785 VTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQR 844 + A VPIG+P N YVLD +L VP V+GELYL G+QLARGY+ RP LTA R Sbjct: 1372 ARETDVA-TVPIGLPQWNTRVYVLDARLRAVPAGVVGELYLAGAQLARGYVSRPDLTADR 1430 Query: 845 FIADPFNPGMRLYRTGDLVR-RNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAV 903 F+A+PF PG R+YRTGDLV R+ LE++GR D QVK RG RIELGE+E+ + P + Sbjct: 1431 FVANPFEPGARMYRTGDLVVWRDQPHRLEYLGRTDFQVKFRGQRIELGEIETALLAQPQI 1490 Query: 904 RHCLVVAEETEAGPMLAAYLVPAAAQ-VDLEEIRAHTAAAVPEYMVPGAFAVIPEIPMTV 962 V+ T G L Y+VP + VD +++ A +P YMVP A V+ P+ Sbjct: 1491 SQAAVLVVPTATGDQLVGYVVPRPGETVDTDDLLAAVGTTLPAYMVPAAIVVLDAFPLNT 1550 Query: 963 SGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLA 1022 SGKLDR+ALP PT R +R P T E + +++A+L G RVGA+D +F LGG+SLLA Sbjct: 1551 SGKLDRKALPEPT-FRAREFRAPVTQVEEIVATVYAELLGLDRVGADDDYFALGGNSLLA 1609 Query: 1023 ARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADDMPLDPKRA 1082 R VA+I +++VR +F+APT LAAR+V + AA A Sbjct: 1610 TRAVARINETLETNVSVRDLFEAPTVVALAARIVP--------GVGRHAA---------A 1652 Query: 1083 RPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXXXXXXXXXX 1142 RP ++ RP+++PLS +Q W +++ A +N+P A+R G Sbjct: 1653 RPPLTRAERPEQVPLSLAQQRMWVLNQLDPASAAYNLPFAIRLAGALDTDALRLAVEDVL 1712 Query: 1143 XRHEALRTNFDEHE--GVPYQIVHPSRTVQLAVRAIDQ--DEFDDVSTQLRRHVFTPESG 1198 RHEALRT F G PYQ V P V A++ D + + E+ Sbjct: 1713 VRHEALRTRFPTTGPGGQPYQQVLPVTAVLPHGLAVEHPADPRARIGELMSAGFDVTEAA 1772 Query: 1199 PLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQF 1258 P+ A LL G + HVL+++VHHI +D SL + DL+ AY AR + AP W LP+Q+ Sbjct: 1773 PVRIA-LLAAGAEEHVLVVVVHHICADGVSLAPLARDLVTAYLARTEGEAPGWAPLPVQY 1831 Query: 1259 ADYAVWQRNTFESNW-----GQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQF 1313 ADYA+WQR ++ +LDYWR LAGLP + + DR RP V +RG V Sbjct: 1832 ADYALWQRAVVGTDEDPDSPAARQLDYWRQQLAGLPGALELPLDRPRPPVPSERGASVGI 1891 Query: 1314 SVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPATAQLV 1373 V A L +LA + A+ FM+ AALAV+L +L G +DIA+G+PVA R E A LV Sbjct: 1892 VVDDDVHAGLVRLAHEHRASLFMVVHAALAVLLARLSGSSDIAIGTPVAGRGERALDDLV 1951 Query: 1374 GLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNPPRALSRNPLF 1433 G+F N + LRT++ + +++L +R+T L A AH ++P ER+ E + + + PLF Sbjct: 1952 GMFVNTLTLRTEVDRAASFQALLEATRETDLAAFAHADIPFERVAEVI-AGGSREQTPLF 2010 Query: 1434 QNMLNFRGEDWALVPRDLTGRGETTVV--PLPVNFEVALLFLAIGMSVTPSGELDVQVIA 1491 Q + F ED+A +L G + + L F++ L+ + GEL + Sbjct: 2011 QVAITF--EDFAPPRAELPGLTISLLESDQLSAKFDLQLVVQPTQHADGTPGELAISFTY 2068 Query: 1492 NADLYE 1497 DL++ Sbjct: 2069 ATDLFD 2074 Score = 569 bits (1466), Expect = e-159 Identities = 368/977 (37%), Positives = 521/977 (53%), Gaps = 79/977 (8%) Query: 511 SDEAELTYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPI 570 +D+ ELTY EL ++RLAR I +G GP D + + +A S+E + ++ A+ K GA Y+P+ Sbjct: 12 ADQRELTYRELDESSSRLARELIDRGMGPGDFVAMGIARSVESVTSLWAIAKTGATYVPV 71 Query: 571 DPAYPDERIDYLITDARPQTVIGRP-------------ELDVAERAA--ADNSDLPLSDS 615 DPAYP +RI +++ D+ + + +LD E+ A A P+S + Sbjct: 72 DPAYPADRIAHILGDSGARVGLTTSAHRGALGGDVDWIDLDDPEQLARIAARPAHPISYA 131 Query: 616 DRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVS 675 DR+RPL H A+VIYTSGSTG+PKGV VSHH +A V A + R +S S Sbjct: 132 DRVRPLTAAHPAWVIYTSGSTGKPKGVLVSHHGLAM-VAAVGARFGFGVGSRATHVTSPS 190 Query: 676 FDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVXXXXXXXXXXXXXXXXX 735 FD SL ++ GA LIV P +G +A+L+ R VT Sbjct: 191 FDFSLMEMLFAFSQGATLIVAPPMVYGGAE-MAELVRREQVTDLLMTPGALESVDPAGLD 249 Query: 736 XQWRQLRHVPVGGEALPGEVADRFAGYFDAELRNHYGPTEAVVCSTHMVVTGSHGARVVP 795 +R V VGGE + E+ R+ D + N YGPTE V T + V Sbjct: 250 ----SVRTVVVGGEKVNPELVARWQRP-DRAMHNVYGPTETTVIVTSAELRADEP---VT 301 Query: 796 IGVPNRNVYAYVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF----- 850 IG V AYVLD +L PVP V+GELYL G LA GY GRP LTA+RF+A+PF Sbjct: 302 IGTAFPGVGAYVLDPRLRPVPAGVVGELYLAGPSLAYGYWGRPELTAERFVANPFAAKSS 361 Query: 851 ----------NPGMRLYRTGDLVRRNHC-GELEFVGRADEQVKIRGFRIELGEVESVITT 899 + G R+YRTGDLVRR G E++GR+D QVKIRG RIELGE+++ + Sbjct: 362 ASESSGGETDSAGSRMYRTGDLVRRRESDGAFEYMGRSDFQVKIRGLRIELGEIDNALIA 421 Query: 900 HPAVRHCLVVAEETEAGPM-LAAY-LVPAAAQVDLEEIRAHTAAAVPEYMVPGAFAVIPE 957 HP + + + +G LAAY L + D E+ +P YMVP + V+ E Sbjct: 422 HPDIDYAATLGVTLPSGTTALAAYVLAKPGTEPDTAEVAEFVGKTLPAYMVPASITVLDE 481 Query: 958 IPMTVSGKLDRRALPAPTPIATRRYREPETATERWICSIFAQLF---GRQRVGAEDSFFG 1014 +P+ GKLDR ALPAP A + +R P E+ + +FA L +RVGA+D FF Sbjct: 482 LPLNAVGKLDRAALPAPV-FAGKAFRAPSNRYEQIVADVFAALLLPDSEERVGADDDFFE 540 Query: 1015 LGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAARLVERFRNDFELDLDNLAADD 1074 LGG+SLLA + VA+I AE + + +F++P+ +GLAA+L ++ L A Sbjct: 541 LGGNSLLATQAVARIGAELDTRVPLPLLFESPSVSGLAAQLQQQ-----------LGAP- 588 Query: 1075 MPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPXXXXXX 1134 +RP RP R+PLS++Q WF R + N+P+A+R G Sbjct: 589 -------SRPALRAVPRPARVPLSYAQQRMWFLNRFDPDSGVNNIPVAVRLTGALHVDAL 641 Query: 1135 XXXXXXXXXRHEALRTNFDEHEGVPYQIVHPSRTVQLA-----VRAIDQDEFDDVSTQLR 1189 RHE LRT + E +G Q V P ++ V A +++ F V T + Sbjct: 642 RAAVRDLVERHEVLRTVYPEVDGDGVQEVLPLDDPRVVPALDVVTATEEELFAQVGT-VA 700 Query: 1190 RHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEIVFDDLIVAYRARLQHNAP 1249 F P ++ L LGP+ HVLL +VHHI D S+ + DL+ AY R+ + P Sbjct: 701 LGGFDVTVAPPVRLRLFALGPEEHVLLCVVHHIAGDGFSMGPLTRDLMSAYSVRVNGDRP 760 Query: 1250 QWDILPIQFADYAVWQRNTF------ESNWGQTELDYWRDALAGLPDEISVATDRARPRV 1303 +W L +Q+ADYA+WQR T +S Q ++ +WR+ LAGLP+++ + DR RP V Sbjct: 761 RWAPLAVQYADYALWQRETLGAEDDPDSLLAQ-QIAFWREQLAGLPEQLDLPADRPRPAV 819 Query: 1304 LGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAA 1363 + R F + A AAL LA+++ +T F + AA +V+L +L G TDIA+G+ VA Sbjct: 820 MSNRAAAYSFELDAELHAALDSLAQQHNSTLFFVMHAAFSVLLARLSGTTDIAVGTAVAG 879 Query: 1364 RVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVEALNP 1423 R + A LVG+F N +VLR+D+ D + +L R T + A AH +LP ERLVE L+P Sbjct: 880 RGDEALDDLVGMFVNTLVLRSDVDPDASFAELLAKVRQTDVAAFAHADLPFERLVELLDP 939 Query: 1424 PRALSRNPLFQNMLNFR 1440 R++ R+PLFQ ML F+ Sbjct: 940 ARSMGRHPLFQVMLTFQ 956 Score = 172 bits (437), Expect = 3e-40 Identities = 193/699 (27%), Positives = 288/699 (41%), Gaps = 72/699 (10%) Query: 40 ERYRLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTY 99 E+ LS Q+RMW L +DP N+ A RLAG +D D L AV DV+ RH LRT + Sbjct: 1663 EQVPLSLAQQRMWVLNQLDPASAAYNLPFAIRLAGALDTDALRLAVEDVLVRHEALRTRF 1722 Query: 100 GVDTEG-EPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRI 158 G +PYQ V L H + + FD+T P+RI Sbjct: 1723 PTTGPGGQPYQQVLPVTAV------LPHGLAVEHPADPRARIGELMSAGFDVTEAAPVRI 1776 Query: 159 TVIRTRADELVLLLVVHHICWDDDSWEVFFGELSAAY-----------NDLPIN--DPAA 205 ++ A+E VL++VVHHIC D S +L AY LP+ D A Sbjct: 1777 ALLAAGAEEHVLVVVVHHICADGVSLAPLARDLVTAYLARTEGEAPGWAPLPVQYADYAL 1836 Query: 206 -QFLSVEVLQNSAAPSVADVGYWAETLRXXXXXXXXXGVSGANPCRRAQRRVRPLP---- 260 Q V ++ +P+ + YW + L G+ GA + R P+P Sbjct: 1837 WQRAVVGTDEDPDSPAARQLDYWRQQLA---------GLPGALELPLDRPRP-PVPSERG 1886 Query: 261 AGLFSRVED--------FARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAA 312 A + V+D A + AS FMV+ AA VL+ R +G+SD + PV R A Sbjct: 1887 ASVGIVVDDDVHAGLVRLAHEHRASLFMVVHAALAVLLARLSGSSDIAIGTPVAGRGERA 1946 Query: 313 AGAL-GYFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPERMGR 371 L G F NTL LR +F + + RET LA FAH + +RV A G Sbjct: 1947 LDDLVGMFVNTLTLRTEVDRAASFQALLEATRETDLAAFAHADIPFERV---AEVIAGGS 2003 Query: 372 DGMDLLVRLGFNMRKSAGGLA-LDGVVVRQLGLGAVAAHLPLSLTIALD------PDDVS 424 L ++ A A L G+ + L ++A L L + P +++ Sbjct: 2004 REQTPLFQVAITFEDFAPPRAELPGLTISLLESDQLSAKFDLQLVVQPTQHADGTPGELA 2063 Query: 425 VEFEYQQQL-SSVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLAQS----H 479 + F Y L V M + +++ A+ + +DIL ER +V A Sbjct: 2064 ISFTYATDLFDEATVAAMARRFERILRAVRADAGAIVGDIDILDPEERGAVAAPEPEFDE 2123 Query: 480 GELVEMPATTMVKXXXXXXXXXXXXXXXXXVSDEAELTYSELHRRANRLARWFIGQGFGP 539 E V T + + + E E ++ EL ++RLAR I +G GP Sbjct: 2124 DEFVVAGGTELPQLLTAAVEDDPDAPAL--AAGETETSFRELDAESSRLARVLIARGCGP 2181 Query: 540 EDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPA-YPDERIDYLITDARPQTVIGRPELD 598 ++ + A + +VA+ AVLKAGAA P+ A P+ + L+ LD Sbjct: 2182 GSVVAVAPARDVGSVVAVWAVLKAGAAVAPVGRAELPEGAVLGLVAGTAGSPDGQWLRLD 2241 Query: 599 VAE--RAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGF 656 AE A S P++ ++R+ LR H A V+ G V++ A+A + Sbjct: 2242 SAEVRDLVAAESSRPVTYANRVTVLRGEHPALVL--------ADGAIVTYDALATAAERM 2293 Query: 657 VAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIV 695 +T E R + + A +A+I GA L++ Sbjct: 2294 QTRAKLTYESRTFRHGGLDSAAFVAEIVAAGAAGATLVL 2332 Database: Amellifera_nr Posted date: Feb 5, 2010 5:10 AM Number of letters in database: 3,846,993,858 Number of sequences in database: 11,275,203 Lambda K H 0.321 0.137 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11275203 Number of Hits to DB: 11,673,399,162 Number of extensions: 496939799 Number of successful extensions: 1272264 Number of sequences better than 10.0: 23532 Number of HSP's gapped: 1182722 Number of HSP's successfully gapped: 45896 Length of query: 1670 Length of database: 3,846,993,858 Length adjustment: 152 Effective length of query: 1518 Effective length of database: 2,133,163,002 Effective search space: 3238141437036 Effective search space used: 3238141437036 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 88 (38.5 bits)