BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= MMAR_4477
         (307 letters)

Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr;
Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr;
trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr;
Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr;
Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr;
Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr;
Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr;
Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr;
Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr;
Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr;
Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr;
Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 
           11,275,203 sequences; 3,846,993,858 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits)  Value

sp|B2HDJ9|ISPE_MYCMM Tax_Id=216594 (ispE)RecName: Full=4-diphosp...   559   e-157
sp|A0PW69|ISPE_MYCUA Tax_Id=362242 (ispE)RecName: Full=4-diphosp...   553   e-155
tr|A2VGU4|A2VGU4_MYCTU Tax_Id=348776 SubName: Full=4-diphosphocy...   508   e-142
sp|P65178|ISPE_MYCTU Tax_Id=1773 (ispE)RecName: Full=4-diphospho...   507   e-142
sp|A5U154|ISPE_MYCTA Tax_Id=419947 (ispE)RecName: Full=4-diphosp...   507   e-142
sp|C1AM02|ISPE_MYCBT Tax_Id=561275 (ispE)RecName: Full=4-diphosp...   507   e-142
sp|A1KHE9|ISPE_MYCBP Tax_Id=410289 (ispE)RecName: Full=4-diphosp...   507   e-142
sp|P65179|ISPE_MYCBO Tax_Id=1765 (ispE)RecName: Full=4-diphospho...   507   e-142
tr|C6DVU2|C6DVU2_MYCTK Tax_Id=478434 SubName: Full=4-diphosphocy...   507   e-142
tr|A5WL34|A5WL34_MYCTF Tax_Id=336982 SubName: Full=4-diphosphocy...   507   e-142
tr|A4KFV1|A4KFV1_MYCTU Tax_Id=395095 SubName: Full=4-diphosphocy...   507   e-142
sp|Q741W1|ISPE_MYCPA Tax_Id=1770 (ispE)RecName: Full=4-diphospho...   474   e-132
sp|Q9CD51|ISPE_MYCLE Tax_Id=1769 (ispE)RecName: Full=4-diphospho...   474   e-132
sp|B8ZU60|ISPE_MYCLB Tax_Id=561304 (ispE)RecName: Full=4-diphosp...   474   e-132
sp|A0QBW1|ISPE_MYCA1 Tax_Id=243243 (ispE)RecName: Full=4-diphosp...   473   e-131
sp|A4T6N7|ISPE_MYCGI Tax_Id=350054 (ispE)RecName: Full=4-diphosp...   448   e-124
sp|A1TEH2|ISPE_MYCVP Tax_Id=350058 (ispE)RecName: Full=4-diphosp...   445   e-123
sp|A0R3D7|ISPE_MYCS2 Tax_Id=246196 (ispE)RecName: Full=4-diphosp...   435   e-120
tr|Q1B417|Q1B417_MYCSS Tax_Id=164756 SubName: Full=4-diphosphocy...   429   e-118
tr|A3Q5H9|A3Q5H9_MYCSJ Tax_Id=164757 SubName: Full=4-diphosphocy...   429   e-118
tr|A1UL31|A1UL31_MYCSK Tax_Id=189918 SubName: Full=4-diphosphocy...   429   e-118
tr|B1MKD5|B1MKD5_MYCA9 Tax_Id=561007 SubName: Full=Probable 4-di...   428   e-118
tr|C1A375|C1A375_RHOE4 Tax_Id=234621 (ispE)SubName: Full=4-dipho...   368   e-100
sp|Q5YPY8|ISPE_NOCFA Tax_Id=37329 (ispE)RecName: Full=4-diphosph...   368   e-100
tr|C1AXZ7|C1AXZ7_RHOOB Tax_Id=632772 (ispE)SubName: Full=4-dipho...   364   6e-99
sp|Q0S4S3|ISPE_RHOSR Tax_Id=101510 (ispE)RecName: Full=4-diphosp...   362   3e-98
tr|C3JWT9|C3JWT9_RHOER Tax_Id=596309 (ispE)SubName: Full=4-(Cyti...   361   7e-98
sp|A4F7X3|ISPE_SACEN Tax_Id=405948 (ispE)RecName: Full=4-diphosp...   356   2e-96
tr|C7MZI6|C7MZI6_SACVD Tax_Id=471857 SubName: Full=4-diphosphocy...   348   6e-94
tr|C2AMH2|C2AMH2_TSUPA Tax_Id=521096 SubName: Full=4-diphosphocy...   347   8e-94
tr|C6WJI0|C6WJI0_ACTMD Tax_Id=446462 SubName: Full=4-diphosphocy...   347   1e-93
tr|D0L708|D0L708_GORB4 Tax_Id=526226 SubName: Full=4-diphosphocy...   320   1e-85
tr|C0U3M6|C0U3M6_9ACTO Tax_Id=526225 SubName: Full=4-diphosphocy...   292   4e-77
tr|C8X6T6|C8X6T6_NAKMY Tax_Id=479431 SubName: Full=4-diphosphocy...   286   2e-75
tr|C7PYX1|C7PYX1_CATAD Tax_Id=479433 SubName: Full=4-diphosphocy...   281   9e-74
tr|A0LR96|A0LR96_ACIC1 Tax_Id=351607 SubName: Full=4-diphosphocy...   280   2e-73
sp|A8M223|ISPE_SALAI Tax_Id=391037 (ispE)RecName: Full=4-diphosp...   270   2e-70
sp|A4X310|ISPE_SALTO Tax_Id=369723 (ispE)RecName: Full=4-diphosp...   268   6e-70
tr|D1A7I4|D1A7I4_THECU Tax_Id=471852 SubName: Full=4-diphosphocy...   266   2e-69
tr|A3TPV6|A3TPV6_9MICO Tax_Id=313589 SubName: Full=4-diphosphocy...   261   7e-68
tr|C4E379|C4E379_STRRS Tax_Id=479432 SubName: Full=4-diphosphocy...   258   6e-67
tr|C1WFA2|C1WFA2_9ACTO Tax_Id=479435 SubName: Full=4-diphosphocy...   253   3e-65
tr|C9YXY5|C9YXY5_STRSW Tax_Id=680198 SubName: Full=Putative isop...   252   4e-65
tr|C9NG07|C9NG07_9ACTO Tax_Id=591167 SubName: Full=4-diphosphocy...   251   6e-65
tr|B5HKR8|B5HKR8_9ACTO Tax_Id=463191 SubName: Full=4-diphosphocy...   250   1e-64
tr|B5HBH1|B5HBH1_STRPR Tax_Id=457429 SubName: Full=4-diphosphocy...   250   1e-64
tr|B1VUG0|B1VUG0_STRGG Tax_Id=455632 SubName: Full=Putative 4-(C...   247   1e-63
tr|B5GPT9|B5GPT9_STRCL Tax_Id=443255 SubName: Full=4-diphosphocy...   246   2e-63
sp|Q820G3|ISPE_STRAW Tax_Id=33903 (ispE)RecName: Full=4-diphosph...   245   4e-63
sp|Q47SX2|ISPE_THEFY Tax_Id=269800 (ispE)RecName: Full=4-diphosp...   244   1e-62

>sp|B2HDJ9|ISPE_MYCMM Tax_Id=216594 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium marinum]
          Length = 307

 Score =  559 bits (1441), Expect = e-157
 Identities = 288/307 (93%), Positives = 289/307 (94%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG
Sbjct: 1   MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIP                  MNSL
Sbjct: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS
Sbjct: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA
Sbjct: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300

Query: 301 PTPGIAE 307
           PTPGIAE
Sbjct: 301 PTPGIAE 307


>sp|A0PW69|ISPE_MYCUA Tax_Id=362242 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium ulcerans]
          Length = 307

 Score =  553 bits (1424), Expect = e-155
 Identities = 284/307 (92%), Positives = 287/307 (93%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG
Sbjct: 1   MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIP                  MNSL
Sbjct: 61  ADKLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELNLPRRDLRMLAA+LGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS
Sbjct: 121 WELNLPRRDLRMLAAQLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA
Sbjct: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300

Query: 301 PTPGIAE 307
           PTPG  E
Sbjct: 301 PTPGTPE 307


>tr|A2VGU4|A2VGU4_MYCTU Tax_Id=348776 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis C]
          Length = 318

 Score =  508 bits (1309), Expect = e-142
 Identities = 259/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 13  VPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 72

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 73  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 132

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 133 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 192

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 193 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 252

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 253 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 312

Query: 301 PTP 303
             P
Sbjct: 313 SAP 315


>sp|P65178|ISPE_MYCTU Tax_Id=1773 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium tuberculosis]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>sp|A5U154|ISPE_MYCTA Tax_Id=419947 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium tuberculosis]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>sp|C1AM02|ISPE_MYCBT Tax_Id=561275 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium bovis]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>sp|A1KHE9|ISPE_MYCBP Tax_Id=410289 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium bovis]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>sp|P65179|ISPE_MYCBO Tax_Id=1765 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium bovis]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>tr|C6DVU2|C6DVU2_MYCTK Tax_Id=478434 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>tr|A5WL34|A5WL34_MYCTF Tax_Id=336982 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>tr|A4KFV1|A4KFV1_MYCTU Tax_Id=395095 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
           ispE;[Mycobacterium tuberculosis str. Haarlem]
          Length = 306

 Score =  507 bits (1306), Expect = e-142
 Identities = 258/303 (85%), Positives = 271/303 (89%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTTVFHAVSLVDEVTVRNAD+LSLE+VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA SGL 
Sbjct: 121 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T AV+ ELDRLR+VG PPRL EPGPVLAALAAGDP+QLAPLLGNEMQAAAVSLDPAL RA
Sbjct: 181 TSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGVEAGALAGIVSGSGPTCAFLC +A SA+DV AQLSGAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 SAP 303


>sp|Q741W1|ISPE_MYCPA Tax_Id=1770 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium paratuberculosis]
          Length = 316

 Score =  474 bits (1221), Expect = e-132
 Identities = 240/303 (79%), Positives = 260/303 (85%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTGS TVRVPGKVNLYLAVGDRR+DGYHELTT+F AVSL+DEVTVRNAD+LSL++VGEG
Sbjct: 11  VPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTIFQAVSLLDEVTVRNADVLSLDIVGEG 70

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMA+HVGRAPDVSI IDKSIP                  MNSL
Sbjct: 71  ADKLPTDERNLAWQAAELMADHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 130

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA   L 
Sbjct: 131 WELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADGELL 190

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T  VF ELDRLR  G PPRL  PGPVLAALAAGD +QLAPLLGNEMQAAAVSL+P LRR 
Sbjct: 191 TRKVFAELDRLRRAGDPPRLPGPGPVLAALAAGDADQLAPLLGNEMQAAAVSLNPGLRRT 250

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGV+AGALAGIVSGSGPTCAFLC +A +A+DV  ++SG GVCRTVR+A+GPV GARVV
Sbjct: 251 LRAGVQAGALAGIVSGSGPTCAFLCPSAAAAVDVGTEVSGVGVCRTVRVASGPVAGARVV 310

Query: 301 PTP 303
           P P
Sbjct: 311 PAP 313


>sp|Q9CD51|ISPE_MYCLE Tax_Id=1769 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium leprae]
          Length = 311

 Score =  474 bits (1220), Expect = e-132
 Identities = 241/303 (79%), Positives = 263/303 (86%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TV+VPGK+NLYLAVGD  D+GYHEL TVFHAVSLVD+VTVRNAD+LSL +VGEG
Sbjct: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTD+ N+AW+AAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WEL+LPRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFA S L 
Sbjct: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           TPAV+TE DRLRDVG+PPRLAEPGPVLAAL A DPEQLAPLLGNE+QAAAVSLDPALR A
Sbjct: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC +A SA+DV AQL+GAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 HAP 303


>sp|B8ZU60|ISPE_MYCLB Tax_Id=561304 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium leprae]
          Length = 311

 Score =  474 bits (1220), Expect = e-132
 Identities = 241/303 (79%), Positives = 263/303 (86%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TV+VPGK+NLYLAVGD  D+GYHEL TVFHAVSLVD+VTVRNAD+LSL +VGEG
Sbjct: 1   MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ +PTD+ N+AW+AAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WEL+LPRRDL MLAA+LGSDVPFALHGGTALGTGRGEELATVLSR TFHWVLAFA S L 
Sbjct: 121 WELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           TPAV+TE DRLRDVG+PPRLAEPGPVLAAL A DPEQLAPLLGNE+QAAAVSLDPALR A
Sbjct: 181 TPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCA 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAG+EAGALAGIVSGSGPTCAFLC +A SA+DV AQL+GAGVCRTVR+ATGPVPGARVV
Sbjct: 241 LRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVV 300

Query: 301 PTP 303
             P
Sbjct: 301 HAP 303


>sp|A0QBW1|ISPE_MYCA1 Tax_Id=243243 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium avium]
          Length = 306

 Score =  473 bits (1217), Expect = e-131
 Identities = 239/303 (78%), Positives = 260/303 (85%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           +PTGS TVRVPGKVNLYLAVGDRR+DGYHELTT+F AVSL+DEVTVRNAD+LSL++VGEG
Sbjct: 1   MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTIFQAVSLLDEVTVRNADVLSLDIVGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD+LPTD+RNLAWQAAELMAEHVGRAPDVSI IDKSIP                  MNSL
Sbjct: 61  ADKLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSL 120

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WELN+PRRDLRMLAA+LGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFA   L 
Sbjct: 121 WELNVPRRDLRMLAAQLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADGELL 180

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           T  VF ELDRLR  G PPRL  PGPVLAALAAGD +QLAPLLGNEMQAAAVSL+P LRR 
Sbjct: 181 TRKVFAELDRLRRAGDPPRLPGPGPVLAALAAGDADQLAPLLGNEMQAAAVSLNPGLRRT 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAGV+AGALAGIVSGSGPTCAFLC +A +A+DV  ++SG GVCRTVR+A+GPV GARVV
Sbjct: 241 LRAGVQAGALAGIVSGSGPTCAFLCPSAAAAVDVGTEVSGVGVCRTVRVASGPVAGARVV 300

Query: 301 PTP 303
           P P
Sbjct: 301 PAP 303


>sp|A4T6N7|ISPE_MYCGI Tax_Id=350054 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium gilvum]
          Length = 322

 Score =  448 bits (1152), Expect = e-124
 Identities = 229/309 (74%), Positives = 254/309 (82%), Gaps = 3/309 (0%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTGS TVRVPGKVNLYL VGDRR DGYHELTTVFHAVSL+DEVTVR AD LSLE VGEG
Sbjct: 13  VPTGSVTVRVPGKVNLYLDVGDRRQDGYHELTTVFHAVSLLDEVTVRTADTLSLEHVGEG 72

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           AD LPTD+RNLAW+AAELMAEHVGRAPDV+I I+K+IP                  MNSL
Sbjct: 73  ADSLPTDERNLAWRAAELMAEHVGRAPDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSL 132

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WEL +PRRDL  LAA+LGSDVPFALHGGTALGTGRGEELATVL+RNTFHWVLAF+  GLS
Sbjct: 133 WELGVPRRDLHALAAQLGSDVPFALHGGTALGTGRGEELATVLTRNTFHWVLAFSPGGLS 192

Query: 181 TPAVFTELDRLR---DVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPAL 237
           T  VF E+DRLR   D   PPRL  P PVLAALA+GDP QLAPLLGN++Q AA+SLDPAL
Sbjct: 193 TAKVFAEIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQLAPLLGNDLQPAALSLDPAL 252

Query: 238 RRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGA 297
           RR LRAG++AGALAG+VSGSGPTCAFLC +A +A+D+   L+GAGVCRTVR+A+GPV GA
Sbjct: 253 RRTLRAGLDAGALAGLVSGSGPTCAFLCTSAGAAVDIGTDLAGAGVCRTVRVASGPVQGA 312

Query: 298 RVVPTPGIA 306
           RVVP P  A
Sbjct: 313 RVVPAPSTA 321


>sp|A1TEH2|ISPE_MYCVP Tax_Id=350058 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium vanbaalenii]
          Length = 322

 Score =  445 bits (1144), Expect = e-123
 Identities = 226/309 (73%), Positives = 256/309 (82%), Gaps = 3/309 (0%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTGS TVRVPGKVNLYL VGDRRDDGYHELTTVFHAVSL+DEVTVR AD+LSLE+ GEG
Sbjct: 13  VPTGSVTVRVPGKVNLYLDVGDRRDDGYHELTTVFHAVSLLDEVTVRTADILSLEMTGEG 72

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ LPTD+RNLAW+AAELMA+HVGR+PDV+I I+K+IP                  MNSL
Sbjct: 73  AESLPTDERNLAWRAAELMADHVGRSPDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSL 132

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WEL +PRRDL  LAA+LGSDVPFALHGGTALGTGRGEELATVL+RNTFHWVLAF+  GLS
Sbjct: 133 WELGVPRRDLHALAAQLGSDVPFALHGGTALGTGRGEELATVLTRNTFHWVLAFSPGGLS 192

Query: 181 TPAVFTELDRLR---DVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPAL 237
           T  VF E+DRLR   D   PPRL  P PVLAALA+GDP QLAPLLGN++Q AA+SLD  L
Sbjct: 193 TAKVFAEIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQLAPLLGNDLQPAALSLDSTL 252

Query: 238 RRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGA 297
           RR LRAGV+AGALAG+VSGSGPTCAFLC +A +A+DV  +L+GAGVCRTVR+A+GPV GA
Sbjct: 253 RRTLRAGVDAGALAGVVSGSGPTCAFLCGSAGAAVDVGTELAGAGVCRTVRVASGPVQGA 312

Query: 298 RVVPTPGIA 306
           RVVP+P  A
Sbjct: 313 RVVPSPSNA 321


>sp|A0R3D7|ISPE_MYCS2 Tax_Id=246196 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Mycobacterium smegmatis]
          Length = 322

 Score =  435 bits (1118), Expect = e-120
 Identities = 224/305 (73%), Positives = 249/305 (81%), Gaps = 2/305 (0%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           V TGS TVRVPGKVNLYL+VGD RDDGYH+LTTVFHAVSL+DEVTVRNAD+LSL ++GEG
Sbjct: 15  VTTGSVTVRVPGKVNLYLSVGDLRDDGYHDLTTVFHAVSLLDEVTVRNADVLSLRMIGEG 74

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ LP D+RNLAW+AAELMAEHVGRAPDV I I+KSIP                  MN+L
Sbjct: 75  AESLPADERNLAWRAAELMAEHVGRAPDVEITIEKSIPVAGGMAGGSADAAGVLVAMNTL 134

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WEL +PRRDL  LAA+LGSDVPFALHGGTALG+GRGE+LATVL+RNTFHWVLAFA  GLS
Sbjct: 135 WELGVPRRDLHALAAQLGSDVPFALHGGTALGSGRGEDLATVLARNTFHWVLAFAHRGLS 194

Query: 181 TPAVFTELDRLR--DVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALR 238
           TP VF ELDRLR       PR  EP PVLAALA+GDP +LA LLGN++Q AA+SL P LR
Sbjct: 195 TPKVFGELDRLRADTTRGLPRTDEPEPVLAALASGDPAELAALLGNDLQPAALSLYPDLR 254

Query: 239 RALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGAR 298
           R LRAGVEAGALAGIVSGSGPTCAFLC +A +ALDV  QLSGAGVCRTVR+A+GPV GA 
Sbjct: 255 RTLRAGVEAGALAGIVSGSGPTCAFLCASAPAALDVGTQLSGAGVCRTVRVASGPVHGAH 314

Query: 299 VVPTP 303
           VVP P
Sbjct: 315 VVPAP 319


>tr|Q1B417|Q1B417_MYCSS Tax_Id=164756 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Mycobacterium sp.]
          Length = 322

 Score =  429 bits (1103), Expect = e-118
 Identities = 217/308 (70%), Positives = 248/308 (80%), Gaps = 5/308 (1%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTGS TVRVPGKVNL+L VGD RDDGYH+LTTVFHAVSL+DEVTV  AD LSL++ GEG
Sbjct: 11  VPTGSVTVRVPGKVNLFLGVGDLRDDGYHDLTTVFHAVSLLDEVTVSTADTLSLDLAGEG 70

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ LPTD+RNLAW+AAELMAEHVGR+PDV+I I+KSIP                  MN L
Sbjct: 71  AESLPTDRRNLAWKAAELMAEHVGRSPDVAISIEKSIPVAGGMAGGSADAAGVLVAMNHL 130

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WE+ +PRRDL  +AA LGSDVPFALHGGTALGTGRGEELATVL+R+TFHWVLAFA  GLS
Sbjct: 131 WEIGVPRRDLHAMAAELGSDVPFALHGGTALGTGRGEELATVLARSTFHWVLAFAYKGLS 190

Query: 181 TPAVFTELDRLRDV-----GSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDP 235
           TP VF ELDRLR         P RL +P P+LAALA+GD  QLAPLLGN++QAAA+SL P
Sbjct: 191 TPKVFRELDRLRATAGAARAEPARLGDPEPMLAALASGDARQLAPLLGNDLQAAALSLSP 250

Query: 236 ALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVP 295
            LRR LRAG++AGALA IVSGSGPTCAFLC ++  A+DV A+L+GAGVCRTVR+A+GPV 
Sbjct: 251 DLRRTLRAGLDAGALAAIVSGSGPTCAFLCASSPQAIDVGARLAGAGVCRTVRVASGPVQ 310

Query: 296 GARVVPTP 303
           GARVVP P
Sbjct: 311 GARVVPAP 318


>tr|A3Q5H9|A3Q5H9_MYCSJ Tax_Id=164757 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-erythritol
           kinase;[Mycobacterium sp.]
          Length = 322

 Score =  429 bits (1103), Expect = e-118
 Identities = 217/308 (70%), Positives = 248/308 (80%), Gaps = 5/308 (1%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTGS TVRVPGKVNL+L VGD RDDGYH+LTTVFHAVSL+DEVTV  AD LSL++ GEG
Sbjct: 11  VPTGSVTVRVPGKVNLFLGVGDLRDDGYHDLTTVFHAVSLLDEVTVSTADTLSLDLAGEG 70

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ LPTD+RNLAW+AAELMAEHVGR+PDV+I I+KSIP                  MN L
Sbjct: 71  AESLPTDRRNLAWKAAELMAEHVGRSPDVAISIEKSIPVAGGMAGGSADAAGVLVAMNHL 130

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WE+ +PRRDL  +AA LGSDVPFALHGGTALGTGRGEELATVL+R+TFHWVLAFA  GLS
Sbjct: 131 WEIGVPRRDLHAMAAELGSDVPFALHGGTALGTGRGEELATVLARSTFHWVLAFAYKGLS 190

Query: 181 TPAVFTELDRLRDV-----GSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDP 235
           TP VF ELDRLR         P RL +P P+LAALA+GD  QLAPLLGN++QAAA+SL P
Sbjct: 191 TPKVFRELDRLRATAGAARAEPARLGDPEPMLAALASGDARQLAPLLGNDLQAAALSLSP 250

Query: 236 ALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVP 295
            LRR LRAG++AGALA IVSGSGPTCAFLC ++  A+DV A+L+GAGVCRTVR+A+GPV 
Sbjct: 251 DLRRTLRAGLDAGALAAIVSGSGPTCAFLCASSPQAIDVGARLAGAGVCRTVRVASGPVQ 310

Query: 296 GARVVPTP 303
           GARVVP P
Sbjct: 311 GARVVPAP 318


>tr|A1UL31|A1UL31_MYCSK Tax_Id=189918 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Mycobacterium sp.]
          Length = 322

 Score =  429 bits (1103), Expect = e-118
 Identities = 217/308 (70%), Positives = 248/308 (80%), Gaps = 5/308 (1%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTGS TVRVPGKVNL+L VGD RDDGYH+LTTVFHAVSL+DEVTV  AD LSL++ GEG
Sbjct: 11  VPTGSVTVRVPGKVNLFLGVGDLRDDGYHDLTTVFHAVSLLDEVTVSTADTLSLDLAGEG 70

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A+ LPTD+RNLAW+AAELMAEHVGR+PDV+I I+KSIP                  MN L
Sbjct: 71  AESLPTDRRNLAWKAAELMAEHVGRSPDVAISIEKSIPVAGGMAGGSADAAGVLVAMNHL 130

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WE+ +PRRDL  +AA LGSDVPFALHGGTALGTGRGEELATVL+R+TFHWVLAFA  GLS
Sbjct: 131 WEIGVPRRDLHAMAAELGSDVPFALHGGTALGTGRGEELATVLARSTFHWVLAFAYKGLS 190

Query: 181 TPAVFTELDRLRDV-----GSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDP 235
           TP VF ELDRLR         P RL +P P+LAALA+GD  QLAPLLGN++QAAA+SL P
Sbjct: 191 TPKVFRELDRLRATAGAARAEPARLGDPEPMLAALASGDARQLAPLLGNDLQAAALSLSP 250

Query: 236 ALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVP 295
            LRR LRAG++AGALA IVSGSGPTCAFLC ++  A+DV A+L+GAGVCRTVR+A+GPV 
Sbjct: 251 DLRRTLRAGLDAGALAAIVSGSGPTCAFLCASSPQAIDVGARLAGAGVCRTVRVASGPVQ 310

Query: 296 GARVVPTP 303
           GARVVP P
Sbjct: 311 GARVVPAP 318


>tr|B1MKD5|B1MKD5_MYCA9 Tax_Id=561007 SubName: Full=Probable
           4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Mycobacterium abscessus]
          Length = 314

 Score =  428 bits (1101), Expect = e-118
 Identities = 214/300 (71%), Positives = 245/300 (81%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPTG+ TVR PGKVNLYLAVGD RDDGYHELTTVFHAVSL D+VTVR+AD+LS++VVG+G
Sbjct: 9   VPTGAVTVRAPGKVNLYLAVGDLRDDGYHELTTVFHAVSLADDVTVRDADVLSIDVVGQG 68

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
              +PTD+RNLAWQAAEL A+HVGRAPDVSIFI+K IP                  MN L
Sbjct: 69  EGTVPTDERNLAWQAAELFADHVGRAPDVSIFINKDIPVAGGMAGGSADAAAVLVAMNEL 128

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           W   +PRRDL  LAA+LGSDVPFALHGGTALGTGRGE+LATVL+RN FHWV AFA  GL+
Sbjct: 129 WHAGVPRRDLHHLAAQLGSDVPFALHGGTALGTGRGEQLATVLARNVFHWVFAFADGGLA 188

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           TP VF E+DRLR+ G PPRLAE   +L ALAAGD  +LAPLLGNE+QAAAVSL+P LRR 
Sbjct: 189 TPQVFKEIDRLRENGDPPRLAEADELLGALAAGDARRLAPLLGNELQAAAVSLNPELRRT 248

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           LRAG  AGALAGIVSGSGPTCAFLC +A+ A+ VSA+L+GAGVCRTVR+A+GPV GA+V+
Sbjct: 249 LRAGESAGALAGIVSGSGPTCAFLCTSADDAVQVSAELAGAGVCRTVRVASGPVHGAQVI 308


>tr|C1A375|C1A375_RHOE4 Tax_Id=234621 (ispE)SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Rhodococcus erythropolis]
          Length = 331

 Score =  368 bits (945), Expect = e-100
 Identities = 186/293 (63%), Positives = 223/293 (76%)

Query: 8   VRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPTD 67
           VR P KVNL+LAVGD RDDGYHELTTVF A+SL D VTV  AD L++ V+G+ A  +PTD
Sbjct: 31  VRAPSKVNLHLAVGDLRDDGYHELTTVFQALSLADTVTVAPADTLTVRVIGDDAAAVPTD 90

Query: 68  KRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELNLPR 127
           + NL W+AAE++A   G AP+V I I+K IP                  +NSLW+L+  R
Sbjct: 91  RANLVWRAAEMLAAEGGVAPNVEIVIEKGIPVAGGMAGGSADAAAALVALNSLWKLDFSR 150

Query: 128 RDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFTE 187
            DL   AARLGSDVPF+LHGGTALGTGRGE+L  VL+R TFHWVLA A+ GLSTP VF E
Sbjct: 151 PDLDAFAARLGSDVPFSLHGGTALGTGRGEQLVPVLTRRTFHWVLALAKGGLSTPVVFRE 210

Query: 188 LDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAGVEA 247
           LD+LR  G+P RL     ++ AL  GDP  LAPLLGN++QAAA+SL+P LRR LRAGVEA
Sbjct: 211 LDKLRAEGTPNRLGTADELIHALTTGDPHVLAPLLGNDLQAAALSLNPDLRRTLRAGVEA 270

Query: 248 GALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           GALAGIVSGSGPTCAFLC  A+SA++VSA+L+GAGVCRTVR+A+GPVPGAR++
Sbjct: 271 GALAGIVSGSGPTCAFLCADAQSAVEVSAELAGAGVCRTVRVASGPVPGARIL 323


>sp|Q5YPY8|ISPE_NOCFA Tax_Id=37329 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Nocardia farcinica]
          Length = 307

 Score =  368 bits (944), Expect = e-100
 Identities = 187/293 (63%), Positives = 223/293 (76%)

Query: 8   VRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPTD 67
           VR P KVNL+L VGD R DGYH+LTTVF A+SL D++ +  A  L+++V GEGA  +PTD
Sbjct: 11  VRAPSKVNLHLGVGDLRPDGYHDLTTVFQALSLGDDLRISPASALTVKVNGEGAAEVPTD 70

Query: 68  KRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELNLPR 127
           + NL W+AA  +A  VGRAP V I IDK IP                  +N LW++ L R
Sbjct: 71  RTNLVWKAAVRLAHLVGRAPLVEIVIDKGIPVAGGMAGGSADAAAALVGLNELWDMGLGR 130

Query: 128 RDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFTE 187
            +L  LAA LGSDVPFALHGGTALGTGRGE L  VLSRNTFHWVLAFA+ GLSTPAVF E
Sbjct: 131 DELSALAAELGSDVPFALHGGTALGTGRGERLLPVLSRNTFHWVLAFAKGGLSTPAVFAE 190

Query: 188 LDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAGVEA 247
           LDRLR+ G PPRL +P  ++ ALA+GDP QLAPLLGN++QAAAVSL P LRR LRAGV A
Sbjct: 191 LDRLREHGDPPRLGDPQALMQALASGDPAQLAPLLGNDLQAAAVSLKPELRRTLRAGVTA 250

Query: 248 GALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           GALAG+VSGSGPTCAFLC +A++A+ V+A+L+GAGV R+VR A+GPVPGARV+
Sbjct: 251 GALAGLVSGSGPTCAFLCESADAAVAVAAELAGAGVARSVRTASGPVPGARVI 303


>tr|C1AXZ7|C1AXZ7_RHOOB Tax_Id=632772 (ispE)SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Rhodococcus opacus]
          Length = 311

 Score =  364 bits (935), Expect = 6e-99
 Identities = 186/293 (63%), Positives = 222/293 (75%)

Query: 8   VRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPTD 67
           VR P KVNL+LAVGD RDDGYHEL TVF A+SL D V+V  A+ LS++V GE A  +PTD
Sbjct: 11  VRAPSKVNLHLAVGDLRDDGYHELKTVFQALSLGDTVSVVPAETLSVKVRGEDARVVPTD 70

Query: 68  KRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELNLPR 127
            RNL WQAAE++A   GR PDV I IDK IP                  +N+LW+L+L R
Sbjct: 71  SRNLVWQAAEMLAAESGRRPDVEIAIDKGIPVAGGMAGGSADAAATLVGLNALWQLDLSR 130

Query: 128 RDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFTE 187
            +L   AA+LGSDVPF+LHGGTA+GTGRGE L  VLSR+TFHWVLA A+ GLSTP VF E
Sbjct: 131 EELDGFAAKLGSDVPFSLHGGTAVGTGRGERLLPVLSRSTFHWVLALAKGGLSTPTVFRE 190

Query: 188 LDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAGVEA 247
           LDRLR  G+PPRL  P  ++ AL  GD   LAPLLGN++Q+AA+SL+P LRR LRAGV A
Sbjct: 191 LDRLRADGNPPRLGGPEDLMHALTTGDAATLAPLLGNDLQSAALSLNPGLRRTLRAGVAA 250

Query: 248 GALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           GALAGIVSGSGPTCAFLC  A++A+ VSA+L+GAGVCRTVR+A+GPVPGAR++
Sbjct: 251 GALAGIVSGSGPTCAFLCADADAAVRVSAELAGAGVCRTVRVASGPVPGARII 303


>sp|Q0S4S3|ISPE_RHOSR Tax_Id=101510 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Rhodococcus sp.]
          Length = 311

 Score =  362 bits (929), Expect = 3e-98
 Identities = 185/293 (63%), Positives = 220/293 (75%)

Query: 8   VRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPTD 67
           VR P KVNL+LAVGD RDDGYHEL TVF A+SL D V+V  A+ LS+ V GE A  +PTD
Sbjct: 11  VRAPSKVNLHLAVGDLRDDGYHELNTVFQALSLSDTVSVAPAETLSVTVRGEDARVVPTD 70

Query: 68  KRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELNLPR 127
             NL WQAAE++A   GR PDV I IDK IP                  +N+LW+L+L R
Sbjct: 71  SSNLVWQAAEMLAAESGRRPDVEIAIDKGIPVAGGMAGGSADAAATLVGLNALWQLDLSR 130

Query: 128 RDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFTE 187
            +L   AA+LGSDVPF+LHGGTA+GTGRGE L  VLSR+TFHWVLA A+ GLSTP VF E
Sbjct: 131 EELDGFAAKLGSDVPFSLHGGTAVGTGRGERLLPVLSRSTFHWVLALAKVGLSTPTVFRE 190

Query: 188 LDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAGVEA 247
           LDRLR  G+PPRL  P  ++ AL  GD   LAPLLGN++Q+AA+SL+P LRR LRAGV A
Sbjct: 191 LDRLRADGNPPRLGGPEDLMHALTTGDAATLAPLLGNDLQSAALSLNPGLRRTLRAGVAA 250

Query: 248 GALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           GALAGIVSGSGPTCAFLC  A++A+ VSA+L+GAGVCRTVR+A+GPVPGAR++
Sbjct: 251 GALAGIVSGSGPTCAFLCAEADAAVRVSAELAGAGVCRTVRVASGPVPGARII 303


>tr|C3JWT9|C3JWT9_RHOER Tax_Id=596309 (ispE)SubName:
           Full=4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol
           kinase; EC=2.7.1.148;[Rhodococcus erythropolis SK121]
          Length = 315

 Score =  361 bits (926), Expect = 7e-98
 Identities = 182/293 (62%), Positives = 222/293 (75%)

Query: 8   VRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPTD 67
           VR P KVNL+LAVGD RDDGYHELTTVF A+SL D +TV  AD L++ V+G+ A  +PTD
Sbjct: 15  VRAPSKVNLHLAVGDLRDDGYHELTTVFQALSLADTLTVTPADTLTVRVIGDDAAAVPTD 74

Query: 68  KRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELNLPR 127
           + NL W+AAE++A   G AP+V I I+K IP                  +N+LW+L+  R
Sbjct: 75  RTNLVWRAAEMLAVEGGVAPNVEIVIEKGIPVAGGMAGGSADAAAALVALNALWKLDFSR 134

Query: 128 RDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFTE 187
            DL   AARLGSDVPF+LHGGTALGTGRGE+L  VL+R+TFHWVLA A+ GLSTP VF E
Sbjct: 135 PDLDAFAARLGSDVPFSLHGGTALGTGRGEQLVPVLTRHTFHWVLALAKGGLSTPVVFRE 194

Query: 188 LDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAGVEA 247
           LD+LR  GSP R+     ++ AL  GD   LA LLGN++QAAA+SL+P LRR LRAGVEA
Sbjct: 195 LDKLRAEGSPKRVGSADALIQALTTGDAHLLASLLGNDLQAAALSLNPDLRRTLRAGVEA 254

Query: 248 GALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           GALAGIVSGSGPTCAFLC  A+SA++VSA+L+GAGVCRTVR+A+GPVPGAR++
Sbjct: 255 GALAGIVSGSGPTCAFLCADAQSAVEVSAELAGAGVCRTVRVASGPVPGARIL 307


>sp|A4F7X3|ISPE_SACEN Tax_Id=405948 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Saccharopolyspora erythraea]
          Length = 318

 Score =  356 bits (913), Expect = 2e-96
 Identities = 191/313 (61%), Positives = 225/313 (71%), Gaps = 11/313 (3%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           VPT   TVRVP KVNL+L+VGD R+DGYHEL TVF A+S+ DEVTV  AD   +EV GEG
Sbjct: 2   VPT-PITVRVPAKVNLHLSVGDTREDGYHELVTVFQALSMTDEVTVHIADEPGIEVRGEG 60

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPD---VSIFIDKSIPXXXXXXXXXXXXXXXXXXM 117
           AD +PT   NLAW+A   +AE  GR PD   V + I+K IP                  +
Sbjct: 61  ADSVPTGPSNLAWKAVRALAERCGRDPDEPGVRVSINKGIPVAGGMAGGSADAAAALLAL 120

Query: 118 NSLWELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARS 177
           N LW L + R +L  +AA +GSDVPFAL GGTALGTGRGE+L  VL+R+TFHWV+A  R 
Sbjct: 121 NHLWRLEMGRDELAGIAADIGSDVPFALQGGTALGTGRGEQLIPVLARHTFHWVIALDRR 180

Query: 178 GLSTPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPAL 237
           GL TP VF+ELDRLR+   P R+ E  PVL ALA+GDP QLA LLGN++QAAAVSL P L
Sbjct: 181 GLETPGVFSELDRLREESRPNRVGEVEPVLEALASGDPRQLALLLGNDLQAAAVSLRPGL 240

Query: 238 RRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGA 297
           RR LRAGV+AGALAGIVSGSGPTCAFLC  A++A+ V+A+LSGAGVCRTVR+A GPVPGA
Sbjct: 241 RRTLRAGVQAGALAGIVSGSGPTCAFLCTDADAAVRVAAELSGAGVCRTVRVAQGPVPGA 300

Query: 298 RVV-------PTP 303
           R+V       PTP
Sbjct: 301 RLVTDDRADRPTP 313


>tr|C7MZI6|C7MZI6_SACVD Tax_Id=471857 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Saccharomonospora viridis]
          Length = 308

 Score =  348 bits (892), Expect = 6e-94
 Identities = 184/296 (62%), Positives = 218/296 (73%), Gaps = 3/296 (1%)

Query: 7   TVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPT 66
           TVRVP K+NL+L+VGD RDDGYHELTTVF A+SL DEVT        +EV GEGA  +P 
Sbjct: 10  TVRVPSKINLHLSVGDVRDDGYHELTTVFQALSLTDEVTALAGGDSGVEVSGEGARSVPK 69

Query: 67  DKRNLAWQAAELMAEHVGR---APDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWEL 123
           ++ NLA +A   +AEHVGR   A  V + I K IP                   + LW L
Sbjct: 70  NEDNLAVRAVRALAEHVGRPERAERVRLVIRKGIPVAGGMAGGSADAAGALLACSILWGL 129

Query: 124 NLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPA 183
           +L R +L  +AA LGSDVPFAL+GGTALGTGRGE+L  VLSR+TFHWVLAF + GLSTP 
Sbjct: 130 DLHRDELAEVAATLGSDVPFALYGGTALGTGRGEQLVPVLSRHTFHWVLAFDQRGLSTPK 189

Query: 184 VFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRA 243
           V+ ELDRLR+ G PPR+  P  +L ALA+GDP +LAPLLGN++QAAA+SL P LRR LRA
Sbjct: 190 VYGELDRLREAGDPPRVGAPEALLEALASGDPHRLAPLLGNDLQAAAISLRPGLRRTLRA 249

Query: 244 GVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARV 299
           GV AGALAG+VSGSGPTCAFLC  A+SAL V+A+L+GAGVCRTVR+A GPVPGARV
Sbjct: 250 GVTAGALAGVVSGSGPTCAFLCSDADSALKVAAELAGAGVCRTVRVAHGPVPGARV 305


>tr|C2AMH2|C2AMH2_TSUPA Tax_Id=521096 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Tsukamurella paurometabola DSM 20162]
          Length = 304

 Score =  347 bits (891), Expect = 8e-94
 Identities = 181/296 (61%), Positives = 213/296 (71%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           S TVR P KVNL+L VGD R DG+HEL TVF A+SL DEV++  AD LSL V GEGA  +
Sbjct: 8   SLTVRAPAKVNLHLGVGDVRPDGFHELQTVFQALSLHDEVSLARADELSLHVSGEGARDV 67

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           PTD  NLA +A   +AE  G  P V I I K IP                    +LW L+
Sbjct: 68  PTDSTNLAARAVAALAERYGLDPAVRIEIAKGIPVAGGMAGGSADAAAALLGAATLWHLD 127

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
           L R +L  +AA LGSDVPF+LHGGTALGTGRGE+L   LSR  FHW LA AR GLSTPAV
Sbjct: 128 LSRSELDEIAATLGSDVPFSLHGGTALGTGRGEQLIPALSRGEFHWTLALAREGLSTPAV 187

Query: 185 FTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAG 244
           + ELDRLR+ G PPR   P  +LAA+A+GDP +LAPLL N++QAAA+SL P LRR LRAG
Sbjct: 188 YRELDRLREAGDPPRAGSPDDLLAAVASGDPNRLAPLLANDLQAAALSLQPGLRRTLRAG 247

Query: 245 VEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           +EAGALAGIVSGSGPTCAFLC   ESA++V ++L+GAGVCRTVR+A+GPVPGA V+
Sbjct: 248 MEAGALAGIVSGSGPTCAFLCINGESAVEVGSELAGAGVCRTVRVASGPVPGAEVL 303


>tr|C6WJI0|C6WJI0_ACTMD Tax_Id=446462 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Actinosynnema mirum]
          Length = 321

 Score =  347 bits (890), Expect = 1e-93
 Identities = 182/307 (59%), Positives = 222/307 (72%), Gaps = 10/307 (3%)

Query: 7   TVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPT 66
           TVRVP KVNL+LAVGD RDDGYH+L T+F A+SL DEVTV  +D   +EV GEGA+ +PT
Sbjct: 10  TVRVPAKVNLHLAVGDLRDDGYHDLVTIFQALSLTDEVTVGASDDPGVEVRGEGAESVPT 69

Query: 67  DKRNLAWQAAELMAEHVGRAPD---VSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWEL 123
           D  NLAW+A  ++AEH GR P+   V + I K+IP                  + +LW+L
Sbjct: 70  DPSNLAWKAVRVLAEHTGRDPEDVKVRVGIRKAIPVAGGMAGGSADAAATLVALAALWKL 129

Query: 124 NLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPA 183
           +  R +L  LA R+G+DVPFAL+GGTALGT RG+ L  VL ++ FHWVLAF + GLSTP 
Sbjct: 130 DTTRDELAELAGRIGADVPFALYGGTALGTDRGDRLVPVLGKHPFHWVLAFDKQGLSTPE 189

Query: 184 VFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRA 243
           VF ELDRLR  G+PPR+ E   VL  L++GDP QLA LLGN++QAAAVSL P LRR LRA
Sbjct: 190 VFRELDRLRAEGNPPRVGEAEAVLEGLSSGDPRQLALLLGNDLQAAAVSLRPNLRRTLRA 249

Query: 244 GVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV--- 300
           GV AGALAG+VSGSGPTCAFLC   ++A+ V+A+L+GAGVCRTVR+A GPVPGARVV   
Sbjct: 250 GVNAGALAGMVSGSGPTCAFLCEDGDTAVRVAAELAGAGVCRTVRVAQGPVPGARVVGAE 309

Query: 301 ----PTP 303
               PTP
Sbjct: 310 ESPRPTP 316


>tr|D0L708|D0L708_GORB4 Tax_Id=526226 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Gordonia bronchialis]
          Length = 315

 Score =  320 bits (821), Expect = 1e-85
 Identities = 173/305 (56%), Positives = 211/305 (69%), Gaps = 5/305 (1%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           V + S T R P KVNL+L VG RR DGYH+L TVF A+SL D+V V     L++ V GEG
Sbjct: 8   VVSDSVTARAPSKVNLHLGVGPRRPDGYHDLVTVFQALSLHDDVRVSPGTDLTVSVRGEG 67

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A  +P D  NLA +A + +AE  GR+P  +I IDKSIP                    ++
Sbjct: 68  ASAVPDDSSNLAARAVQALAEWCGRSPVAAIDIDKSIPVAGGMAGGSADAAAALVAAAAM 127

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           W+L++ R DL  +AA LGSDVPFALHG TALGTGRGE+L +VLSR  FHWVLA AR GLS
Sbjct: 128 WKLDVDRDDLSDIAAGLGSDVPFALHGATALGTGRGEQLISVLSRGEFHWVLALAREGLS 187

Query: 181 TPAVFTELDRLRDVGSPPRLAE-----PGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDP 235
           TP V+ ELDRLRD  S   + +     P  ++ ALAAGDP  +APLL N++Q AA+SL P
Sbjct: 188 TPQVYAELDRLRDNRSDDAMTDDPLRRPDDLMQALAAGDPRAVAPLLHNDLQPAALSLQP 247

Query: 236 ALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVP 295
           ALRR LRAGV+AGAL GIVSGSGPTCAFLC    SA++V+A+LSGAGV R+VR A+GPVP
Sbjct: 248 ALRRTLRAGVDAGALNGIVSGSGPTCAFLCLDEGSAVNVAAELSGAGVARSVRTASGPVP 307

Query: 296 GARVV 300
           G RV+
Sbjct: 308 GTRVI 312


>tr|C0U3M6|C0U3M6_9ACTO Tax_Id=526225 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Geodermatophilus obscurus DSM 43160]
          Length = 321

 Score =  292 bits (747), Expect = 4e-77
 Identities = 164/305 (53%), Positives = 198/305 (64%), Gaps = 8/305 (2%)

Query: 4   GSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGA-- 61
           G+   R P KVN++LAVG  R DG+HEL TV+ AVSL D VTVR  D LSL V GEG   
Sbjct: 16  GAVVARAPAKVNVHLAVGPLRSDGFHELRTVYLAVSLFDTVTVRPGDGLSLTVTGEGTTG 75

Query: 62  ---DRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMN 118
              D +PTD+RNL W+AAEL+AE  G   D +I IDKSIP                  ++
Sbjct: 76  SGPDAVPTDRRNLVWRAAELLAERAGVPADAAITIDKSIPAAAGLAGGSADAAAALVALD 135

Query: 119 SLWELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSG 178
           +LW  +  R +L  LAARLGSDVPF+L GG ALG+GRGE+L+ VL+R  + WVL  A  G
Sbjct: 136 ALWATHATRGELTALAARLGSDVPFSLLGGVALGSGRGEQLSPVLARRRWDWVLGIAGEG 195

Query: 179 LSTPAVFTELDRLRDVGSPP---RLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDP 235
           LSTPAV+ ELDRLR  G  P    L+ P PV+AAL +G    LA  LGN++Q  A+SL P
Sbjct: 196 LSTPAVYAELDRLRAAGRVPDGEELSSPDPVIAALRSGPVPALAAALGNDLQPPALSLRP 255

Query: 236 ALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVP 295
            LRRALRA   AGA A +VSGSGPT A L    ESA+ ++A L+G GV RTVR   GPVP
Sbjct: 256 DLRRALRAATGAGAAAAVVSGSGPTVAALAEDEESAVRLTAALAGEGVYRTVRAVHGPVP 315

Query: 296 GARVV 300
           GAR+V
Sbjct: 316 GARLV 320


>tr|C8X6T6|C8X6T6_NAKMY Tax_Id=479431 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Nakamurella multipartita]
          Length = 317

 Score =  286 bits (733), Expect = 2e-75
 Identities = 159/305 (52%), Positives = 198/305 (64%), Gaps = 4/305 (1%)

Query: 2   PTG-SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           P G S  VR P K+NLYLAVGD R+DGYH+L TVF AV L DE+TVR A   ++      
Sbjct: 13  PAGPSVRVRAPAKINLYLAVGDVREDGYHDLVTVFQAVDLADELTVRPARRSAVRTTPP- 71

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
            D +P   +NLA  AA L+A        V+I I K IP                    +L
Sbjct: 72  -DGVPVGAKNLAGVAARLLATRTKSGGPVAIDIAKQIPVAGGMAGGSADAAAALVGCAAL 130

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           WEL + R++L  +   +G+DVPFAL GGTALGTGRG+ L+ V++R   HWVLA A  GLS
Sbjct: 131 WELRVQRQELIEIGREIGADVPFALAGGTALGTGRGDLLSPVMTRARLHWVLAIADHGLS 190

Query: 181 TPAVFTELDRLR-DVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRR 239
           TPAVF ELDRLR   G PP +     +LAAL +G+P ++A  LGN++QAAA+SL P LRR
Sbjct: 191 TPAVFAELDRLRAQGGGPPPVRPVDTMLAALTSGEPAKIAAALGNDLQAAAISLAPGLRR 250

Query: 240 ALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARV 299
            LRAG +AGAL G+VSGSGPT A LC  AESA  V+A+L+G+G CR+VR+A GP PGARV
Sbjct: 251 TLRAGEQAGALGGLVSGSGPTVALLCADAESAGAVAAELAGSGTCRSVRVAAGPAPGARV 310

Query: 300 VPTPG 304
           +P  G
Sbjct: 311 LPNGG 315


>tr|C7PYX1|C7PYX1_CATAD Tax_Id=479433 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Catenulispora acidiphila]
          Length = 316

 Score =  281 bits (718), Expect = 9e-74
 Identities = 158/301 (52%), Positives = 187/301 (62%), Gaps = 4/301 (1%)

Query: 3   TGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGAD 62
           T S TVRVP KVNL L+VG  R DGYH+L TVFHAV L DEV    AD L++   GEG  
Sbjct: 17  TESVTVRVPAKVNLALSVGPLRSDGYHDLATVFHAVGLFDEVNAAAADTLAVTCEGEGQV 76

Query: 63  RLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            +P D  NLAW+AAEL+A  VGR+P V + + K IP                   ++LW 
Sbjct: 77  EVPLDDTNLAWRAAELLARTVGRSPGVRLHLTKGIPVAGGMAGGSADAAGALVACDALWG 136

Query: 123 LNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTP 182
             L R DL +LAA+LGSDVPFALHGGTA+GTGRGE++  VL+R  FHWV AFA  GLSTP
Sbjct: 137 TGLSRDDLHVLAAQLGSDVPFALHGGTAMGTGRGEQITPVLARGEFHWVFAFAHDGLSTP 196

Query: 183 AVFTELDRLRDVGSPPRLAEPG---PVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRR 239
           AVF ELDRLR+       A PG    +L AL AGD   L   L N++   A SL P LR 
Sbjct: 197 AVFHELDRLREAAGEEATA-PGVEDELLRALRAGDSTLLGAALRNDLTRPATSLRPDLRA 255

Query: 240 ALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARV 299
            L+AG EAGAL  ++SGSGPTCAFL   A +A  V+A L  A   R VR A GP  GA +
Sbjct: 256 TLQAGREAGALGTLLSGSGPTCAFLAADAVAAATVAAALEAAPSVRAVRRALGPAAGAHL 315

Query: 300 V 300
           +
Sbjct: 316 L 316


>tr|A0LR96|A0LR96_ACIC1 Tax_Id=351607 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Acidothermus cellulolyticus]
          Length = 332

 Score =  280 bits (716), Expect = 2e-73
 Identities = 153/304 (50%), Positives = 195/304 (64%), Gaps = 8/304 (2%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           S TV+   K+NLYL VG  R DGYH+L TVFHAVSL DE+TV  ++ LSLE+ GE A+++
Sbjct: 24  SVTVQASAKINLYLRVGPLRSDGYHDLATVFHAVSLHDEITVEESEHLSLEICGEQAEKV 83

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P D  NLA +AA L+A  +GR P V I + K IP                    +LW   
Sbjct: 84  PLDGDNLAVRAAMLLARRLGREPGVRIVLRKGIPVAGGMAGGSADAAATLIACAALWHAE 143

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
           LP  +L  LAA+LGSDVPF + GGTALG GRGE LA VL+   ++WVLA A  GLSTP V
Sbjct: 144 LPHDELMTLAAQLGSDVPFCVVGGTALGHGRGERLAPVLAAGPWYWVLALADGGLSTPQV 203

Query: 185 FTELDR--------LRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPA 236
           + E DR        LR+ G    L  P  +L+AL  GDP++L  LL N++Q AAV+L PA
Sbjct: 204 YAEFDRRRASGDGELREPGDGEPLDVPAALLSALRDGDPKRLGSLLHNDLQDAAVALRPA 263

Query: 237 LRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPG 296
           L R L AG++ GAL GIV GSGPTCAFL    ++A+D++A+L+G+G  R VR ATGP  G
Sbjct: 264 LGRVLEAGLDGGALGGIVCGSGPTCAFLVSDQDAAVDLAARLAGSGWVRAVRCATGPAAG 323

Query: 297 ARVV 300
           AR++
Sbjct: 324 ARIL 327


>sp|A8M223|ISPE_SALAI Tax_Id=391037 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Salinispora arenicola]
          Length = 315

 Score =  270 bits (689), Expect = 2e-70
 Identities = 150/299 (50%), Positives = 185/299 (61%), Gaps = 2/299 (0%)

Query: 3   TGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGAD 62
           +G   VRVP K+NL+L VG  R DGYHEL TV+HA+S+ DE+T R  D L+L + GEGA 
Sbjct: 16  SGPFRVRVPAKINLHLGVGPLRPDGYHELNTVYHAISIHDELTARRGDTLALTMEGEGAG 75

Query: 63  RLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            L  D  NL  +AA  +A H G  P   + + K IP                   ++LW 
Sbjct: 76  ELALDDSNLVIRAARALAAHAGVPPYARLHLRKQIPLAGGLAGGSADAAAALVACDALWG 135

Query: 123 LNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNT-FHWVLAFARSGLST 181
             L R +L  +AA LGSDVPF +HGGTALGTGRGE ++ VL+R T +HWV+A A  GLST
Sbjct: 136 TGLSRDELAGIAADLGSDVPFLIHGGTALGTGRGEAVSPVLARPTVWHWVVAVADGGLST 195

Query: 182 PAVFTELDRLRDVGSPPR-LAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           P  + ELDRLRD G+    L     +LAAL   DP  LA +LGN++Q AA++L P+L   
Sbjct: 196 PVAYRELDRLRDAGAASTPLGSSDALLAALRQRDPRVLAGVLGNDLQDAALALRPSLAAT 255

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARV 299
           L+AG  AGALAGIVSGSGPTC FL   A  A  V+ +LS   VCR  R A GPV GARV
Sbjct: 256 LKAGEAAGALAGIVSGSGPTCVFLAANAADAERVAGELSALDVCRQARTARGPVAGARV 314


>sp|A4X310|ISPE_SALTO Tax_Id=369723 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Salinispora tropica]
          Length = 315

 Score =  268 bits (685), Expect = 6e-70
 Identities = 149/299 (49%), Positives = 185/299 (61%), Gaps = 2/299 (0%)

Query: 3   TGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGAD 62
           +G   VRVP K+NL+L VG  R DGYHEL TV+HA+S+ DE+T R  D L+L + GEGA 
Sbjct: 16  SGPVRVRVPAKINLHLGVGPLRRDGYHELNTVYHAISIHDELTARRGDTLTLTMEGEGAG 75

Query: 63  RLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
            L  D+ NL  +AA  +A   G  P   + + K IP                   ++LW 
Sbjct: 76  ELALDESNLVIRAARALAGSTGVPPHARLHLRKQIPLAGGLAGGSADAAAALVACDALWG 135

Query: 123 LNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNT-FHWVLAFARSGLST 181
             L R +L  +AA LGSDVPF +HGGTALGTGRGE ++ VL+R T +HWV+A A  GLST
Sbjct: 136 TGLTRDELAEIAAGLGSDVPFLIHGGTALGTGRGEAVSPVLARPTVWHWVVAVADGGLST 195

Query: 182 PAVFTELDRLRDVGSP-PRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           P  + ELDRLR  G+  P L     +LAAL   DP  LA  LGN++Q AA++L PAL   
Sbjct: 196 PVAYRELDRLRAAGAAGPPLGSTDTLLAALRQPDPRVLAAALGNDLQDAALALRPALAAT 255

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARV 299
           L+AG  AGALAGIVSGSGPTC FL   A  A  ++A+LS   VCR  R A GPV GAR+
Sbjct: 256 LKAGEAAGALAGIVSGSGPTCVFLAAGAADAERIAAELSALDVCRQARTAHGPVAGARI 314


>tr|D1A7I4|D1A7I4_THECU Tax_Id=471852 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-
           erythritolkinase;[Thermomonospora curvata DSM 43183]
          Length = 314

 Score =  266 bits (680), Expect = 2e-69
 Identities = 156/300 (52%), Positives = 188/300 (62%), Gaps = 8/300 (2%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           + TVRVP KVNL LAVG  R DGYH+L  VFHAVSL DEVT   AD L++ V GE  + +
Sbjct: 16  AVTVRVPAKVNLQLAVGPLRADGYHDLVNVFHAVSLFDEVTAEPADELTVTVRGESVEGV 75

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P  + NLA +AA L+AE +G  PDV++ I K+IP                     LW+ +
Sbjct: 76  PVGEDNLAARAARLLAERIGARPDVALTIHKTIPVAGGMAGGSADAAAALVACARLWDAS 135

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
             R  L  LAA LGSDVPFAL GGTA+GTGRGE L  V     FHWV A A  GLSTPAV
Sbjct: 136 GVR--LADLAADLGSDVPFALLGGTAIGTGRGEVLTPVPVGGRFHWVFALADGGLSTPAV 193

Query: 185 FTELDRLRDVG----SPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           + E DRLR+       PPR ++   +L AL  GD E L   L N++Q AA+SL P+LRR 
Sbjct: 194 YAECDRLREAAGQRVGPPRRSQ--ALLDALERGDAEALGAALANDLQPAALSLRPSLRRT 251

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           L+AG E GAL  +VSGSGPTCAFL R+A  A +++A LS AG+ R    A GPVPGA VV
Sbjct: 252 LQAGREGGALGALVSGSGPTCAFLARSAGHAAELAAALSEAGLVRAAVSAHGPVPGATVV 311


>tr|A3TPV6|A3TPV6_9MICO Tax_Id=313589 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Janibacter sp. HTCC2649]
          Length = 312

 Score =  261 bits (667), Expect = 7e-68
 Identities = 151/298 (50%), Positives = 183/298 (61%), Gaps = 4/298 (1%)

Query: 7   TVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRLPT 66
           TVRVP KVNL L VG  RDDG+H L+TV+ AV+L D+VTV   D  S  V G  AD +PT
Sbjct: 12  TVRVPAKVNLELLVGPLRDDGFHTLSTVYQAVNLHDDVTVALDDEWSCSVSGPYADIVPT 71

Query: 67  DKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELNLP 126
           D  NLA +AA L+AE  G    V I I KSIP                   + LW L L 
Sbjct: 72  DASNLALRAARLLAEETGVETPVHISIAKSIPVAGGMAGGSADAAATLVACDRLWSLGLS 131

Query: 127 RRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFT 186
             +L   AA LGSDVPF + GGTA+G+GRGE LA VL+R ++HWV A +  GLSTP V+ 
Sbjct: 132 TEELEEYAAELGSDVPFLIRGGTAVGSGRGERLAPVLARGSYHWVFAISDIGLSTPDVYA 191

Query: 187 ELDRLRDVGSPPRLAEPGP---VLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRA 243
           E DRLR   S P  A P P   ++ AL +GDP  LAP L N++Q AA+SL P L   L +
Sbjct: 192 ECDRLRGK-SKPADASPEPNSQLMIALRSGDPHILAPQLTNDLQDAAISLRPELGELLAS 250

Query: 244 GVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVVP 301
           G+E GAL G+VSGSGPT AFL    ESA+D++  L+  G  R VR A GPV GA V+P
Sbjct: 251 GMEFGALGGVVSGSGPTVAFLVEDVESAIDLTVALTATGAAREVRKAIGPVHGAHVIP 308


>tr|C4E379|C4E379_STRRS Tax_Id=479432 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Streptosporangium roseum DSM 43021]
          Length = 300

 Score =  258 bits (659), Expect = 6e-67
 Identities = 150/300 (50%), Positives = 180/300 (60%), Gaps = 6/300 (2%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           S TVRVP KVNL LAVG  RDDGYH+L  VFHAVS+ DEVT      +S+ V GE AD++
Sbjct: 3   SVTVRVPAKVNLQLAVGPLRDDGYHDLVNVFHAVSIFDEVTATAETGMSVRVEGESADQV 62

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P D  NLA +AA  +A H GR+  V++ I K+IP                   N LW L 
Sbjct: 63  PEDDDNLAIRAALALARHAGRSYGVNLIIRKAIPVAGGMAGGSADAAAALVACNELWGLG 122

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
           LP  DL  +AA LGSDVPFAL GGTA+GTGRGE L  +     FHWV A A  GLST  V
Sbjct: 123 LPVEDLMEIAADLGSDVPFALLGGTAVGTGRGERLTPLEVGGRFHWVFALADGGLSTAKV 182

Query: 185 FTELDRLRDVGSP----PRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           + E DR+R+        PR A+  P+LAAL  GD + L   L N++Q AAV L  +L R 
Sbjct: 183 YAECDRMREATGEEIAWPRAAD--PLLAALRRGDAKALGSELANDLQPAAVMLRRSLART 240

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           L AG E GA+  +VSGSGPTCAFL  +   A +++  L  AGV R V  A GPVPG  VV
Sbjct: 241 LEAGREQGAVGTLVSGSGPTCAFLAESEAHAGELALSLKAAGVARDVITAYGPVPGPTVV 300


>tr|C1WFA2|C1WFA2_9ACTO Tax_Id=479435 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           EC=2.7.1.148;[Kribbella flavida DSM 17836]
          Length = 311

 Score =  253 bits (645), Expect = 3e-65
 Identities = 145/306 (47%), Positives = 189/306 (61%), Gaps = 10/306 (3%)

Query: 2   PTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVT--VRNADLLSLEVVGE 59
           P+   TVR P K+NL L+VG  R DG+H L TV+ AV+L D+VT  VR+   +++EVVG+
Sbjct: 5   PSAQVTVRSPAKINLGLSVGPPRPDGFHPLATVYQAVALYDDVTATVRDDAEVTVEVVGD 64

Query: 60  GADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNS 119
            A  +PTD  NLA +AA L+         V + I K+IP                   N 
Sbjct: 65  FAVNVPTDDSNLAVRAARLLQAEYDVEEGVDLSIRKTIPVAGGMAGGSTDAAATLVACNR 124

Query: 120 LWELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGL 179
           LW L L + +L+ LAA LGSDVPF L G TALG GRGE +  V+SR TFHWV A A  GL
Sbjct: 125 LWGLQLTQSELQHLAAELGSDVPFCLVGHTALGQGRGEHVTEVMSRGTFHWVFAIADGGL 184

Query: 180 STPAVFTELDRLRDVGSPPRLAEPGPV----LAALAAGDPEQLAPLLGNEMQAAAVSLDP 235
           STP V+ ELDR+R    P R  EP  V    LAAL +G    LA  + N++QAAA+SL P
Sbjct: 185 STPEVYAELDRIR----PLRRVEPPEVRPELLAALLSGRSAALAVAISNDLQAAALSLRP 240

Query: 236 ALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVP 295
            L   L+ G++ GALA ++SGSGPTC FL   +  A+D++ +L+ +G+CR VR A GPVP
Sbjct: 241 ELGDTLQFGLDQGALAAMISGSGPTCLFLAADSRRAVDLAVELAESGLCRMVRQAEGPVP 300

Query: 296 GARVVP 301
           GAR++P
Sbjct: 301 GARILP 306


>tr|C9YXY5|C9YXY5_STRSW Tax_Id=680198 SubName: Full=Putative
           isopentenyl monophosphate kinase;[Streptomyces scabies]
          Length = 304

 Score =  252 bits (643), Expect = 4e-65
 Identities = 147/298 (49%), Positives = 178/298 (59%), Gaps = 2/298 (0%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           S TVRVP KVN+ LAVG  R DG+H+L  VF AV L DEVT   AD L++   G GAD++
Sbjct: 2   SVTVRVPAKVNVQLAVGGARPDGFHDLANVFLAVGLYDEVTATPADELTVTCAGPGADQV 61

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P D+ NLA +AA  +AE  G  P V + I K IP                   ++LW  N
Sbjct: 62  PLDRTNLAARAALALAERHGVEPAVHLHIAKDIPVAGGMAGGSADAAGALLACDTLWGTN 121

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
             R +L  + A LGSDVPF+L GG ALGTGRGE+L  +    TFHWV A A  GLSTPAV
Sbjct: 122 ASRDELLDMCAELGSDVPFSLVGGAALGTGRGEQLRPLDVGGTFHWVFAVADGGLSTPAV 181

Query: 185 FTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLL--GNEMQAAAVSLDPALRRALR 242
           + E DRL    + P       +L ALA GD + LA  L   N +Q AA+SL P L   L 
Sbjct: 182 YREFDRLHADDTVPEPVASQVLLDALAKGDADALAAFLPDSNGLQPAALSLFPKLADTLT 241

Query: 243 AGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           AG  AGALA +VSGSGPT AFL R A++A  V+A+L  +G CRT R+A  P PGA VV
Sbjct: 242 AGRAAGALAALVSGSGPTTAFLARDADAAHSVAAELLASGTCRTARVAVSPAPGATVV 299


>tr|C9NG07|C9NG07_9ACTO Tax_Id=591167 SubName:
           Full=4-diphosphocytidyl-2C-methyl-D-erythritol
           kinase;[Streptomyces flavogriseus ATCC 33331]
          Length = 299

 Score =  251 bits (642), Expect = 6e-65
 Identities = 148/298 (49%), Positives = 172/298 (57%)

Query: 3   TGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGAD 62
           T S TVRVP KVN+ LAVG  R DG+H+L  VF AV L DEVTV  AD L +   G  A 
Sbjct: 2   TRSVTVRVPAKVNVQLAVGAPRPDGFHDLANVFLAVGLYDEVTVTPADTLRVTCEGPDAA 61

Query: 63  RLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWE 122
           ++P D  NLA +AA  +A   G APDV I I K IP                   ++LW 
Sbjct: 62  QVPLDTTNLAARAALALAARYGVAPDVHIHIAKDIPVAGGMAGGSADGAAALLACDTLWG 121

Query: 123 LNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTP 182
               R +L  + A LGSDVPF+L GG ALG GRGE L  V    TFHWV A A  GLSTP
Sbjct: 122 TGASREELLEICAELGSDVPFSLVGGAALGVGRGERLTAVEVGGTFHWVFAVADGGLSTP 181

Query: 183 AVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALR 242
           AV+ E DRL      P  A    +L AL  GD   LA  LGN++QAAA+SL P+L   L 
Sbjct: 182 AVYGEFDRLTAGTDVPEPAASPALLTALRKGDVTALADALGNDLQAAALSLRPSLAGTLA 241

Query: 243 AGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           AG  AGALA +VSGSGPT AFL    ESA  V+  L  +G CR+ R+A  P PGA VV
Sbjct: 242 AGTAAGALAALVSGSGPTTAFLTADEESARKVADALLASGTCRSARVAPSPAPGATVV 299


>tr|B5HKR8|B5HKR8_9ACTO Tax_Id=463191 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Streptomyces sviceus ATCC 29083]
          Length = 299

 Score =  250 bits (639), Expect = 1e-64
 Identities = 146/296 (49%), Positives = 175/296 (59%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           S TVRVP KVN+ LAVG  R DG+H+L  VF AV L DEVTV  AD L +   G  A ++
Sbjct: 2   SVTVRVPAKVNVQLAVGAARPDGFHDLANVFLAVGLHDEVTVTPADGLRVTCAGPDAGQV 61

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P D+ NLA +AA  +AE  G  PDV + I K IP                   ++LW   
Sbjct: 62  PLDRTNLAARAAIALAERHGLEPDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTG 121

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
             R +L  + A LGSDVPF+L GG ALGTGRGE+L  +    TF WV A A  GLSTPAV
Sbjct: 122 ASRAELLDICAELGSDVPFSLVGGAALGTGRGEKLRPLDVGGTFSWVFAMAERGLSTPAV 181

Query: 185 FTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAG 244
           F E DRL      P       +L ALA GDP+ LA  + N++Q AA+SL P L   L AG
Sbjct: 182 FREFDRLTAGLDVPEPVASEALLDALAEGDPDALAAAVSNDLQPAALSLFPELADTLAAG 241

Query: 245 VEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
             AGALAG+VSGSGPT AFL R   SA  ++  L  +G CR VR A+GPVPGA V+
Sbjct: 242 SAAGALAGLVSGSGPTTAFLARDPGSAAKIADALRASGTCRAVRTASGPVPGATVM 297


>tr|B5HBH1|B5HBH1_STRPR Tax_Id=457429 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Streptomyces pristinaespiralis ATCC 25486]
          Length = 299

 Score =  250 bits (639), Expect = 1e-64
 Identities = 144/296 (48%), Positives = 177/296 (59%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           S TVRVP KVN+ LAVG  R DG+H+L  VF AV L DEVTVR A  L+L   G  A ++
Sbjct: 2   SVTVRVPAKVNVQLAVGGARPDGFHDLANVFLAVGLHDEVTVRPAPSLTLTCSGPDAGQV 61

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P D+ NLA +AAEL+A   G +PDV I IDK IP                   ++LW L 
Sbjct: 62  PLDRTNLAARAAELLAARHGISPDVHIHIDKDIPVAGGMAGGSADGAGALLACDALWGLG 121

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
             R +L  + A LGSDVPF+L GG ALGTGRGE L  +    +F WV A A  GLSTPAV
Sbjct: 122 SSREELLSICAELGSDVPFSLVGGAALGTGRGERLTELEVGGSFSWVFAVADGGLSTPAV 181

Query: 185 FTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAG 244
           + E DRL +  S P      P+L AL  GD   LA  + N++Q AA+SL P+L   L  G
Sbjct: 182 YGEFDRLNEGVSVPDPVASPPLLDALRTGDVLALADAVSNDLQPAALSLRPSLADTLAVG 241

Query: 245 VEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
             AGALA +VSGSGPT AFL +  ++A  V++ L  +G CR  R+A  P  GARVV
Sbjct: 242 TAAGALAALVSGSGPTTAFLVKDEDAAETVASALRASGTCRAARVAGAPAVGARVV 297


>tr|B1VUG0|B1VUG0_STRGG Tax_Id=455632 SubName: Full=Putative
           4-(Cytidine-5-diphospho)-2-C-methyl-D-erythritol
           kinase;[Streptomyces griseus subsp. griseus]
          Length = 302

 Score =  247 bits (631), Expect = 1e-63
 Identities = 145/300 (48%), Positives = 175/300 (58%), Gaps = 1/300 (0%)

Query: 1   VPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEG 60
           V TG  TVRVP KVN+ LAVG  R DG+H+L  VF AV L DEVT   AD L +   G  
Sbjct: 4   VRTG-VTVRVPAKVNVQLAVGAARPDGFHDLANVFLAVGLYDEVTAAPADELRVTCSGPD 62

Query: 61  ADRLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSL 120
           A ++P D+ NLA +AA  +AE  G  P V + I K IP                   ++L
Sbjct: 63  AGQVPLDRTNLAARAALALAERYGIDPAVHLHIAKDIPVAGGMAGGSADGAAALVACDAL 122

Query: 121 WELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLS 180
           W     R +L  + A LGSDVPF+L GG ALGTGRGE+L  +    TFHWV A A  GLS
Sbjct: 123 WGTGASRDELLAICAELGSDVPFSLVGGAALGTGRGEKLTPIEVGGTFHWVFAVADGGLS 182

Query: 181 TPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRA 240
           TPAV+ E DRL      P       +LAAL +GDP  LA  L N++Q AA+SL P+L   
Sbjct: 183 TPAVYGEFDRLTAGTEVPEPTASPALLAALRSGDPGALAGALSNDLQPAALSLRPSLAET 242

Query: 241 LRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
           L AG EAGA A +VSGSGPT AFL   AE+A  V+A L  +G CR  R+A  P PGA V+
Sbjct: 243 LAAGTEAGAPAALVSGSGPTTAFLVPDAETAEKVAAALLTSGTCRNARVAASPAPGAHVI 302


>tr|B5GPT9|B5GPT9_STRCL Tax_Id=443255 SubName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol
           kinase;[Streptomyces clavuligerus ATCC 27064]
          Length = 317

 Score =  246 bits (628), Expect = 2e-63
 Identities = 142/296 (47%), Positives = 171/296 (57%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           + TVRVP KVN+ L VG  R DGYH+L  VF AVSL D VT R AD L++   G GA ++
Sbjct: 22  TVTVRVPAKVNIQLGVGGARPDGYHDLANVFLAVSLYDRVTARPADTLTITCEGPGAAQV 81

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P D  NLA +AA+L+AE  G APDV + I K IP                   ++LW L 
Sbjct: 82  PLDGTNLAARAAKLLAERHGIAPDVHLHIAKEIPVAGGMAGGSADGAAALLACDTLWGLG 141

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
             R +L  L ARLGSDVPF+L GG ALG GRGE L  +     FHWV A A  GLSTPAV
Sbjct: 142 SSRAELLELCARLGSDVPFSLVGGAALGVGRGERLTPLEVGGEFHWVFAVADGGLSTPAV 201

Query: 185 FTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAG 244
           + E DRL +    P      P+LAAL  GD   L   L N++Q AA+SL P+L   L  G
Sbjct: 202 YGEFDRLNEGVRVPAPKASEPLLAALRTGDAPALGAALSNDLQPAALSLRPSLATTLTTG 261

Query: 245 VEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
             AGALA +VSGSGPT AFL   A SA+ ++  L  +G C     AT P  GA V+
Sbjct: 262 RAAGALAALVSGSGPTTAFLASDAVSAVAIARALLASGTCVATHTATSPAAGATVL 317


>sp|Q820G3|ISPE_STRAW Tax_Id=33903 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Streptomyces avermitilis]
          Length = 297

 Score =  245 bits (626), Expect = 4e-63
 Identities = 143/296 (48%), Positives = 173/296 (58%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLSLEVVGEGADRL 64
           S TVRVP KVN+ LAVG  R DG+H+L  VF AV L DEVT   AD L +   G  A ++
Sbjct: 2   SVTVRVPAKVNVQLAVGGARPDGFHDLANVFLAVGLYDEVTATPADELRITCEGPDAAQV 61

Query: 65  PTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXXMNSLWELN 124
           P D+ NLA +AA  +A   G APDV + I K IP                   ++LW  N
Sbjct: 62  PLDRTNLAARAAIALAARHGLAPDVHLHIAKDIPVAGGMAGGSADAAGALLACDTLWGTN 121

Query: 125 LPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAV 184
             R +L  + A LGSDVPF+L GG ALGTGRGE L  +    TFHWV A A  GLSTPAV
Sbjct: 122 ASRGELLDICAELGSDVPFSLVGGAALGTGRGERLRELEVGGTFHWVFAVADGGLSTPAV 181

Query: 185 FTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPALRRALRAG 244
           + E DRL +    P       +L ALA GD   LA  + N++Q AA+SL P+L   L AG
Sbjct: 182 YGEFDRLSEGVRVPEPVASQELLDALAKGDAVALAAAVSNDLQPAALSLFPSLSDTLEAG 241

Query: 245 VEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPGARVV 300
             AGALA +VSGSGPT AFL R A+ A  V+  L  +G CRT R+A  P PGA V+
Sbjct: 242 RAAGALAALVSGSGPTTAFLTRDADGADAVAQALLASGTCRTARVAPSPAPGATVL 297


>sp|Q47SX2|ISPE_THEFY Tax_Id=269800 (ispE)RecName:
           Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
           Short=CMK; EC=2.7.1.148; AltName:
           Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
           kinase;[Thermobifida fusca]
          Length = 307

 Score =  244 bits (622), Expect = 1e-62
 Identities = 150/304 (49%), Positives = 178/304 (58%), Gaps = 10/304 (3%)

Query: 5   SATVRVPGKVNLYLAVGDRRDDGYHELTTVFHAVSLVDEVTVRNADLLS-----LEVVGE 59
           S TVRVP KVNL LAVG  R DGYH L  VFHAVSL DEVTV     L+     L V GE
Sbjct: 6   SVTVRVPAKVNLRLAVGPVRGDGYHGLVNVFHAVSLYDEVTVSPRSDLAPGQAVLSVDGE 65

Query: 60  GAD---RLPTDKRNLAWQAAELMAEHVGRAPDVSIFIDKSIPXXXXXXXXXXXXXXXXXX 116
             D   R+P D  NLA +AA L+A HV  A  V I + K+IP                  
Sbjct: 66  RPDHVARVPLDDSNLAARAAALLARHVPHATGVHIHVHKAIPVAGGMAGGSADAAAALVA 125

Query: 117 MNSLWELNLPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFAR 176
            ++LWE   PR  L  LAA LGSDV F L G TA+GTGRGE+L+ +  + TFHWV A   
Sbjct: 126 CDALWEGGTPRERLLELAAELGSDVAFPLIGCTAVGTGRGEQLSPLPVQGTFHWVFALVD 185

Query: 177 SGLSTPAVFTELDRLRDVGSPPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSLDPA 236
            GLST  VF E DRLR     P L +   ++AALAAGD  +L   L N++Q AA++L P 
Sbjct: 186 GGLSTTKVFAEYDRLRPDAPEPTLDDA--LVAALAAGDARRLGAALTNDLQPAALALRPE 243

Query: 237 LRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGVCRTVRIATGPVPG 296
           L   L AG  AGAL  +VSGSGPTCAFL  +A+ A +++A L  +G C     A GPVPG
Sbjct: 244 LGDLLEAGRAAGALGALVSGSGPTCAFLAESADHARELAAALRASGTCADTVTAHGPVPG 303

Query: 297 ARVV 300
           A VV
Sbjct: 304 ATVV 307


  Database: Amellifera_nr
    Posted date:  Feb 5, 2010  5:10 AM
  Number of letters in database: 3,846,993,858
  Number of sequences in database:  11,275,203
  
Lambda     K      H
   0.318    0.135    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 11275203
Number of Hits to DB: 2,206,533,966
Number of extensions: 90183603
Number of successful extensions: 274963
Number of sequences better than 10.0: 2015
Number of HSP's gapped: 275106
Number of HSP's successfully gapped: 2034
Length of query: 307
Length of database: 3,846,993,858
Length adjustment: 137
Effective length of query: 170
Effective length of database: 2,302,291,047
Effective search space: 391389477990
Effective search space used: 391389477990
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 80 (35.4 bits)