BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MMAR_4825 (1244 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,275,203 sequences; 3,846,993,858 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|B2HGB8|B2HGB8_MYCMM Tax_Id=216594 (metH)SubName: Full=5-methy... 2456 0.0 tr|A0PL93|A0PL93_MYCUA Tax_Id=362242 (metH)SubName: Full=5-methy... 2446 0.0 tr|A1UHU7|A1UHU7_MYCSK Tax_Id=189918 SubName: Full=Methionine sy... 2306 0.0 tr|A3Q1B3|A3Q1B3_MYCSJ Tax_Id=164757 SubName: Full=Methionine sy... 2304 0.0 tr|A1TAR9|A1TAR9_MYCVP Tax_Id=350058 SubName: Full=Methionine sy... 2274 0.0 tr|Q1B778|Q1B778_MYCSS Tax_Id=164756 SubName: Full=Methionine sy... 2271 0.0 tr|A4TB79|A4TB79_MYCGI Tax_Id=350054 SubName: Full=Methionine sy... 2264 0.0 tr|B1MPF9|B1MPF9_MYCA9 Tax_Id=561007 SubName: Full=5-methyltetra... 2259 0.0 tr|C2AQ69|C2AQ69_TSUPA Tax_Id=521096 SubName: Full=Methionine sy... 2258 0.0 tr|A0QF92|A0QF92_MYCA1 Tax_Id=243243 (metH)SubName: Full=Methion... 2256 0.0 tr|Q73YU6|Q73YU6_MYCPA Tax_Id=1770 (metH)SubName: Full=MetH;[Myc... 2254 0.0 tr|A0QZX6|A0QZX6_MYCS2 Tax_Id=246196 (metH)SubName: Full=Methion... 2251 0.0 tr|A1SJZ9|A1SJZ9_NOCSJ Tax_Id=196162 SubName: Full=Methionine sy... 1949 0.0 tr|C0U0I5|C0U0I5_9ACTO Tax_Id=526225 SubName: Full=Methionine sy... 1840 0.0 tr|A3TL58|A3TL58_9MICO Tax_Id=313589 SubName: Full=MetH;[Janibac... 1798 0.0 tr|B9ZN58|B9ZN58_9GAMM Tax_Id=396595 SubName: Full=Methionine sy... 1569 0.0 tr|B8GLZ0|B8GLZ0_THISH Tax_Id=396588 SubName: Full=Methionine sy... 1564 0.0 tr|B7VI88|B7VI88_VIBSL Tax_Id=575788 SubName: Full=Methionine sy... 1548 0.0 tr|Q3SM63|Q3SM63_THIDA Tax_Id=292415 SubName: Full=5-methyltetra... 1547 0.0 sp|Q7MHB1|METH_VIBVY Tax_Id=196600 (metH)RecName: Full=Methionin... 1546 0.0 tr|Q0A6R3|Q0A6R3_ALHEH Tax_Id=187272 SubName: Full=Methionine sy... 1545 0.0 tr|A6D961|A6D961_9VIBR Tax_Id=391591 (metH)SubName: Full=B12-dep... 1545 0.0 tr|B7UPG9|B7UPG9_ECO27 Tax_Id=574521 (metH)SubName: Full=Homocys... 1544 0.0 tr|Q2BMJ6|Q2BMJ6_9GAMM Tax_Id=207954 SubName: Full=Cobalamin-dep... 1544 0.0 tr|B7LKA7|B7LKA7_ESCF3 Tax_Id=585054 (metH)SubName: Full=Homocys... 1543 0.0 sp|Q8DCJ7|METH_VIBVU Tax_Id=672 (metH)RecName: Full=Methionine s... 1543 0.0 tr|Q8FB59|Q8FB59_ECOL6 Tax_Id=217992 (metH)SubName: Full=5-methy... 1542 0.0 tr|Q0TA51|Q0TA51_ECOL5 Tax_Id=362663 SubName: Full=5-methyltetra... 1542 0.0 tr|B7N2L7|B7N2L7_ECO81 Tax_Id=585397 (metH)SubName: Full=Homocys... 1542 0.0 tr|C2DTM3|C2DTM3_ECOLX Tax_Id=525281 (metH)SubName: Full=B12-dep... 1542 0.0 tr|B3HRN6|B3HRN6_ECOLX Tax_Id=340197 (metH)SubName: Full=Methion... 1542 0.0 tr|Q1R3S9|Q1R3S9_ECOUT Tax_Id=364106 (metH)SubName: Full=5-methy... 1542 0.0 tr|C1HQ30|C1HQ30_9ESCH Tax_Id=469598 SubName: Full=B12-dependent... 1542 0.0 tr|A3Y1W0|A3Y1W0_9VIBR Tax_Id=314290 SubName: Full=5-methyltetra... 1542 0.0 tr|B7MJ00|B7MJ00_ECO45 Tax_Id=585035 (metH)SubName: Full=Homocys... 1540 0.0 tr|A1AII8|A1AII8_ECOK1 Tax_Id=405955 (metH)SubName: Full=5-methy... 1540 0.0 tr|Q8X5Z8|Q8X5Z8_ECO57 Tax_Id=83334 (metH)SubName: Full=B12-depe... 1539 0.0 tr|B5Z0B1|B5Z0B1_ECO5E Tax_Id=444450 (metH)SubName: Full=Methion... 1539 0.0 tr|C6V1X2|C6V1X2_ECO5T Tax_Id=544404 (metH)SubName: Full=Homocys... 1539 0.0 tr|C3SHY2|C3SHY2_ECOLX Tax_Id=562 SubName: Full=B12-dependent ho... 1539 0.0 tr|B6ZVL4|B6ZVL4_ECO57 Tax_Id=502346 (metH)SubName: Full=Methion... 1539 0.0 tr|B3BTV8|B3BTV8_ECO57 Tax_Id=478007 (metH)SubName: Full=Methion... 1539 0.0 tr|B3BBX0|B3BBX0_ECO57 Tax_Id=478008 (metH)SubName: Full=Methion... 1539 0.0 tr|B3AZV3|B3AZV3_ECO57 Tax_Id=478006 (metH)SubName: Full=Methion... 1539 0.0 tr|B3AH12|B3AH12_ECO57 Tax_Id=478005 (metH)SubName: Full=Methion... 1539 0.0 tr|B3A6K2|B3A6K2_ECO57 Tax_Id=478004 (metH)SubName: Full=Methion... 1539 0.0 tr|B2PJ51|B2PJ51_ECO57 Tax_Id=444453 (metH)SubName: Full=Methion... 1539 0.0 tr|B2P9M2|B2P9M2_ECO57 Tax_Id=444452 (metH)SubName: Full=Methion... 1539 0.0 tr|B2NQG8|B2NQG8_ECO57 Tax_Id=444451 (metH)SubName: Full=Methion... 1539 0.0 tr|B7NRU9|B7NRU9_ECO7I Tax_Id=585057 (metH)SubName: Full=Homocys... 1538 0.0 >tr|B2HGB8|B2HGB8_MYCMM Tax_Id=216594 (metH)SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase, MetH;[Mycobacterium marinum] Length = 1244 Score = 2456 bits (6365), Expect = 0.0 Identities = 1233/1244 (99%), Positives = 1234/1244 (99%) Query: 1 VSAFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGN 60 +SAFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGN Sbjct: 1 MSAFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGN 60 Query: 61 NDLLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXX 120 NDLLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNY Sbjct: 61 NDLLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYAGAALAR 120 Query: 121 XXXDEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG 180 DEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG Sbjct: 121 AAADEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG 180 Query: 181 ADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNA 240 ADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNA Sbjct: 181 ADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNA 240 Query: 241 IRHAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGY 300 IRHAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGY Sbjct: 241 IRHAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGY 300 Query: 301 IAEFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDS 360 IAEFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDS Sbjct: 301 IAEFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDS 360 Query: 361 LFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD 420 LFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD Sbjct: 361 LFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD 420 Query: 421 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCR 480 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCR Sbjct: 421 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCR 480 Query: 481 KYGAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE 540 KYGAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE Sbjct: 481 KYGAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE 540 Query: 541 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM 600 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM Sbjct: 541 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM 600 Query: 601 GIVNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRS 660 GIVNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRS Sbjct: 601 GIVNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRS 660 Query: 661 LPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGK 720 LPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGK Sbjct: 661 LPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGK 720 Query: 721 MFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIV 780 MFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIV Sbjct: 721 MFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIV 780 Query: 781 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM 840 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM Sbjct: 781 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM 840 Query: 841 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD 900 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD Sbjct: 841 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD 900 Query: 901 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI 960 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI Sbjct: 901 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI 960 Query: 961 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN 1020 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN Sbjct: 961 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN 1020 Query: 1021 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT 1080 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT Sbjct: 1021 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT 1080 Query: 1081 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA 1140 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA Sbjct: 1081 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA 1140 Query: 1141 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH 1200 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH Sbjct: 1141 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH 1200 Query: 1201 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED Sbjct: 1201 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 >tr|A0PL93|A0PL93_MYCUA Tax_Id=362242 (metH)SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase, MetH;[Mycobacterium ulcerans] Length = 1277 Score = 2446 bits (6340), Expect = 0.0 Identities = 1229/1244 (98%), Positives = 1230/1244 (98%) Query: 1 VSAFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGN 60 VSAFEPNIRPDCTDALTA LGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGN Sbjct: 34 VSAFEPNIRPDCTDALTATLGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGN 93 Query: 61 NDLLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXX 120 NDLLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNY Sbjct: 94 NDLLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYAGAALAR 153 Query: 121 XXXDEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG 180 DEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG Sbjct: 154 AAADEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG 213 Query: 181 ADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNA 240 ADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNA Sbjct: 214 ADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNA 273 Query: 241 IRHAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGY 300 IRHAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGY Sbjct: 274 IRHAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGY 333 Query: 301 IAEFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDS 360 IAEFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNI+DDS Sbjct: 334 IAEFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNITDDS 393 Query: 361 LFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD 420 LF NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD Sbjct: 394 LFENIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD 453 Query: 421 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCR 480 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCR Sbjct: 454 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCR 513 Query: 481 KYGAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE 540 KYGAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE Sbjct: 514 KYGAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE 573 Query: 541 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM 600 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM Sbjct: 574 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM 633 Query: 601 GIVNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRS 660 GIVNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGK EDPAAAEWRS Sbjct: 634 GIVNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKPEDPAAAEWRS 693 Query: 661 LPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGK 720 LPVRERITHALVKGIDAHVDADTEELRAEIAAAGGR IEVIEGPLMDGMNVVGDLFGAGK Sbjct: 694 LPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRLIEVIEGPLMDGMNVVGDLFGAGK 753 Query: 721 MFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIV 780 MFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIV Sbjct: 754 MFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIV 813 Query: 781 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM 840 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM Sbjct: 814 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM 873 Query: 841 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD 900 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD Sbjct: 874 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD 933 Query: 901 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI 960 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI Sbjct: 934 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI 993 Query: 961 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN 1020 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN Sbjct: 994 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN 1053 Query: 1021 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT 1080 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT Sbjct: 1054 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT 1113 Query: 1081 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA 1140 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA Sbjct: 1114 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA 1173 Query: 1141 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH 1200 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH Sbjct: 1174 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH 1233 Query: 1201 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED Sbjct: 1234 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1277 >tr|A1UHU7|A1UHU7_MYCSK Tax_Id=189918 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Mycobacterium sp.] Length = 1264 Score = 2306 bits (5975), Expect = 0.0 Identities = 1143/1241 (92%), Positives = 1193/1241 (96%) Query: 4 FEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDL 63 FEPNIRPDCTD LT AL RIMVIDGAMGTAIQRDRPDEAGYRGERF +WP+ L GNNDL Sbjct: 24 FEPNIRPDCTDELTTALNSRIMVIDGAMGTAIQRDRPDEAGYRGERFTEWPTALQGNNDL 83 Query: 64 LSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXX 123 L+LTQPQIIE IHREYL+AGADILETNTFNANA+SL+DYDMA+L+YELNY Sbjct: 84 LNLTQPQIIEAIHREYLEAGADILETNTFNANAISLADYDMADLSYELNYAGAALARKAA 143 Query: 124 DEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADI 183 DE+ST EKPRYVAGA+GPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGAD+ Sbjct: 144 DEYSTAEKPRYVAGAIGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADL 203 Query: 184 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 243 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH Sbjct: 204 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 263 Query: 244 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAE 303 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDE+PE QAGYIA+ Sbjct: 264 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDESPERQAGYIAD 323 Query: 304 FADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFV 363 FA+AGLVNLVGGCCGTAPPHIAEIAK VEGK PRE+PEIPVATRLSGLEPLNI+DDSLFV Sbjct: 324 FAEAGLVNLVGGCCGTAPPHIAEIAKAVEGKPPREVPEIPVATRLSGLEPLNITDDSLFV 383 Query: 364 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 423 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT Sbjct: 384 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 443 Query: 424 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYG 483 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKF+REARLCRKYG Sbjct: 444 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFIREARLCRKYG 503 Query: 484 AAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT 543 AAVVVMAFDE+GQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT Sbjct: 504 AAVVVMAFDEQGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT 563 Query: 544 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV 603 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIH+VFLFHAIKAGLDMGIV Sbjct: 564 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHSVFLFHAIKAGLDMGIV 623 Query: 604 NAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPV 663 NAGALVPYDSIDPELR+RIEDVVLNRREDAAERLLEIAERFN K++DPAAAEWRSLPV Sbjct: 624 NAGALVPYDSIDPELRDRIEDVVLNRREDAAERLLEIAERFNKSEKADDPAAAEWRSLPV 683 Query: 664 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 723 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL Sbjct: 684 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 743 Query: 724 PQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVV 783 PQVVKSARVMKKAVAYLLP+IEAEK Q+G+T TNG IIMATVKGDVHDIGKNIVGVV Sbjct: 744 PQVVKSARVMKKAVAYLLPYIEAEKEQNGTTASKDTNGTIIMATVKGDVHDIGKNIVGVV 803 Query: 784 LQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIP 843 LQCNN+ V+DLGVMVPA+KIL AA+E+DADIIGLSGLITPSLDEMVNFAA MEREG++IP Sbjct: 804 LQCNNFEVIDLGVMVPAQKILDAAKEHDADIIGLSGLITPSLDEMVNFAAEMEREGLEIP 863 Query: 844 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAA 903 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRP LLEATA DYA+ Sbjct: 864 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATAKDYAS 923 Query: 904 LRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQ 963 LRERH+QKNERPMLTLEKARANRTPI+WDGYTPP+PAQG+GVREF DYDLAELREYIDWQ Sbjct: 924 LRERHAQKNERPMLTLEKARANRTPIEWDGYTPPVPAQGVGVREFLDYDLAELREYIDWQ 983 Query: 964 PFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVG 1023 PFFNAWEMKGRFPDILNNP +GEAARKLY+DAQEMLDTLI+EKWLTANGVIGFFPANAVG Sbjct: 984 PFFNAWEMKGRFPDILNNPVSGEAARKLYDDAQEMLDTLIKEKWLTANGVIGFFPANAVG 1043 Query: 1024 DDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGL 1083 DDIEVYTD+TR EVLTTLHNLRQQGEHR GIPNRSLGDFIAP++TGL DYVGAFAVTAGL Sbjct: 1044 DDIEVYTDDTRTEVLTTLHNLRQQGEHRDGIPNRSLGDFIAPRETGLRDYVGAFAVTAGL 1103 Query: 1084 GSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIG 1143 GSQ +IVEFK A DDYSAILLES+ADRLAEAFAERMHQRVR+EFWGYQPDEQLDNEALIG Sbjct: 1104 GSQDRIVEFKAANDDYSAILLESLADRLAEAFAERMHQRVRKEFWGYQPDEQLDNEALIG 1163 Query: 1144 ERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQS 1203 E+Y GIRPAPGYPACPEHTEK TL+ELMDV +RTGIELTESMAMWPGAAVSGWYFSHPQS Sbjct: 1164 EKYSGIRPAPGYPACPEHTEKATLWELMDVQERTGIELTESMAMWPGAAVSGWYFSHPQS 1223 Query: 1204 QYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 QYFVVGR+AQDQVADYAKRKGWTLPEAERWL PNLGYNPED Sbjct: 1224 QYFVVGRLAQDQVADYAKRKGWTLPEAERWLAPNLGYNPED 1264 >tr|A3Q1B3|A3Q1B3_MYCSJ Tax_Id=164757 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Mycobacterium sp.] Length = 1264 Score = 2304 bits (5971), Expect = 0.0 Identities = 1142/1241 (92%), Positives = 1192/1241 (96%) Query: 4 FEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDL 63 FEPNIRPDCTD LT AL RIMVIDGAMGTAIQRDRPDEAGYRGERF +WP+ L GNNDL Sbjct: 24 FEPNIRPDCTDELTTALNSRIMVIDGAMGTAIQRDRPDEAGYRGERFTEWPTALQGNNDL 83 Query: 64 LSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXX 123 L+LTQPQIIE IHREYL+AGADILETNTFNANA+SL+DYDMA+L+YELNY Sbjct: 84 LNLTQPQIIEAIHREYLEAGADILETNTFNANAISLADYDMADLSYELNYAGAALARKAA 143 Query: 124 DEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADI 183 DE+ST EKPRYVAGA+GPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGAD+ Sbjct: 144 DEYSTAEKPRYVAGAIGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADL 203 Query: 184 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 243 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH Sbjct: 204 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 263 Query: 244 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAE 303 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDE+PE QAGYIA+ Sbjct: 264 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDESPERQAGYIAD 323 Query: 304 FADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFV 363 FA+AGLVNLVGGCCGTAPPHIAEIAK VEGK PRE+PEIPVATRLSGLEPLNI+DDSLFV Sbjct: 324 FAEAGLVNLVGGCCGTAPPHIAEIAKAVEGKPPREVPEIPVATRLSGLEPLNITDDSLFV 383 Query: 364 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 423 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT Sbjct: 384 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 443 Query: 424 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYG 483 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKF+REARLCRKYG Sbjct: 444 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFIREARLCRKYG 503 Query: 484 AAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT 543 AAVVVMAFDE+GQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT Sbjct: 504 AAVVVMAFDEQGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT 563 Query: 544 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV 603 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIH+VFLFHAIKAGLDMGIV Sbjct: 564 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHSVFLFHAIKAGLDMGIV 623 Query: 604 NAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPV 663 NAGALVPYDSIDPELR+RIEDVVLNRREDAAERLLEIAERFN K++DPAAAEWRSLPV Sbjct: 624 NAGALVPYDSIDPELRDRIEDVVLNRREDAAERLLEIAERFNKSEKADDPAAAEWRSLPV 683 Query: 664 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 723 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL Sbjct: 684 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 743 Query: 724 PQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVV 783 PQVVKSARVMKKAVAYLLP+IEAEK Q+G+T TNG IIMATVKGDVHDIGKNIVGVV Sbjct: 744 PQVVKSARVMKKAVAYLLPYIEAEKEQNGTTASKDTNGTIIMATVKGDVHDIGKNIVGVV 803 Query: 784 LQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIP 843 LQCNN+ V+DLGVMVPA+KIL AA+E+DADIIGLSGLITPSLDEMVNFA MEREG++IP Sbjct: 804 LQCNNFEVIDLGVMVPAQKILDAAKEHDADIIGLSGLITPSLDEMVNFAVEMEREGLEIP 863 Query: 844 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAA 903 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRP LLEATA DYA+ Sbjct: 864 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATAKDYAS 923 Query: 904 LRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQ 963 LRERH+QKNERPMLTLEKARANRTPI+WDGYTPP+PAQG+GVREF DYDLAELREYIDWQ Sbjct: 924 LRERHAQKNERPMLTLEKARANRTPIEWDGYTPPVPAQGVGVREFLDYDLAELREYIDWQ 983 Query: 964 PFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVG 1023 PFFNAWEMKGRFPDILNNP +GEAARKLY+DAQEMLDTLI+EKWLTANGVIGFFPANAVG Sbjct: 984 PFFNAWEMKGRFPDILNNPVSGEAARKLYDDAQEMLDTLIKEKWLTANGVIGFFPANAVG 1043 Query: 1024 DDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGL 1083 DDIEVYTD+TR EVLTTLHNLRQQGEHR GIPNRSLGDFIAP++TGL DYVGAFAVTAGL Sbjct: 1044 DDIEVYTDDTRTEVLTTLHNLRQQGEHRDGIPNRSLGDFIAPRETGLRDYVGAFAVTAGL 1103 Query: 1084 GSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIG 1143 GSQ +IVEFK A DDYSAILLES+ADRLAEAFAERMHQRVR+EFWGYQPDEQLDNEALIG Sbjct: 1104 GSQDRIVEFKAANDDYSAILLESLADRLAEAFAERMHQRVRKEFWGYQPDEQLDNEALIG 1163 Query: 1144 ERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQS 1203 E+Y GIRPAPGYPACPEHTEK TL+ELMDV +RTGIELTESMAMWPGAAVSGWYFSHPQS Sbjct: 1164 EKYSGIRPAPGYPACPEHTEKATLWELMDVQERTGIELTESMAMWPGAAVSGWYFSHPQS 1223 Query: 1204 QYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 QYFVVGR+AQDQVADYAKRKGWTLPEAERWL PNLGYNPED Sbjct: 1224 QYFVVGRLAQDQVADYAKRKGWTLPEAERWLAPNLGYNPED 1264 >tr|A1TAR9|A1TAR9_MYCVP Tax_Id=350058 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Mycobacterium vanbaalenii] Length = 1251 Score = 2274 bits (5893), Expect = 0.0 Identities = 1117/1243 (89%), Positives = 1193/1243 (95%), Gaps = 2/1243 (0%) Query: 4 FEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDL 63 +EPNIRPDCTD L ALG+RI+VIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDL Sbjct: 9 WEPNIRPDCTDELKVALGRRIVVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDL 68 Query: 64 LSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXX 123 L+LTQPQIIEGIHREYL+AGADILETNTFNANAVSLSDY M +L+YELNY Sbjct: 69 LTLTQPQIIEGIHREYLEAGADILETNTFNANAVSLSDYGMEKLSYELNYAGAALARKAC 128 Query: 124 DEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADI 183 DEFSTP+KPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYL+AA+GLVDGGAD+ Sbjct: 129 DEFSTPDKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLDAASGLVDGGADL 188 Query: 184 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 243 +I+ETIFD+LNAKAAVFA+ETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWN++RH Sbjct: 189 LIVETIFDTLNAKAAVFAIETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNSVRH 248 Query: 244 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAE 303 A+P+AVGLNCALGAPEMRPY+AEM+RIADTFVSCYPNAGLPNAFGEYDE+P QAGY+AE Sbjct: 249 ARPLAVGLNCALGAPEMRPYLAEMSRIADTFVSCYPNAGLPNAFGEYDESPTRQAGYVAE 308 Query: 304 FADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFV 363 FA+AGLVNLVGGCCGT P HIAEIA+VV+GK PR++PEIPVATRL+GLEPLNI+DDSLFV Sbjct: 309 FAEAGLVNLVGGCCGTTPAHIAEIARVVDGKPPRKVPEIPVATRLAGLEPLNITDDSLFV 368 Query: 364 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 423 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT Sbjct: 369 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 428 Query: 424 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYG 483 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKF+REARLCRKYG Sbjct: 429 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFIREARLCRKYG 488 Query: 484 AAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT 543 AAVVVMAFDE+GQADNLERRK+ICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHA+ Sbjct: 489 AAVVVMAFDEQGQADNLERRKQICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAS 548 Query: 544 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV 603 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV Sbjct: 549 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV 608 Query: 604 NAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPV 663 NAGALVPYDSIDPELR+RIEDVVLNRREDAAERLLEIAERFN+KG++ED AEWRSLPV Sbjct: 609 NAGALVPYDSIDPELRDRIEDVVLNRREDAAERLLEIAERFNSKGETEDAGVAEWRSLPV 668 Query: 664 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 723 RERITHALVKGIDAHVD DTEELRAEIA AGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL Sbjct: 669 RERITHALVKGIDAHVDDDTEELRAEIADAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 728 Query: 724 PQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVV 783 PQVVKSARVMKKAVAYLLPFIEAEKA++G+++ TNG I+MATVKGDVHDIGKNIVGVV Sbjct: 729 PQVVKSARVMKKAVAYLLPFIEAEKAENGTSDSKDTNGTIVMATVKGDVHDIGKNIVGVV 788 Query: 784 LQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIP 843 LQCNN+ V+DLGVMVPA+KIL AA+E++ADIIGLSGLITPSLDEM NFA MEREG++IP Sbjct: 789 LQCNNFEVIDLGVMVPAQKILDAAKEHNADIIGLSGLITPSLDEMANFAVEMEREGLEIP 848 Query: 844 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAA 903 LLIGGATTSRAHTAVK+APRR GPVVWVKDASRSVPVAAALLDD+QRP LLEAT ADYA+ Sbjct: 849 LLIGGATTSRAHTAVKIAPRRGGPVVWVKDASRSVPVAAALLDDRQRPALLEATEADYAS 908 Query: 904 LRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQ 963 LRERH+QKNERPMLTLEKARANRTP++WDGYTPP+PAQGLGVREF DYDLAELREYIDWQ Sbjct: 909 LRERHAQKNERPMLTLEKARANRTPVEWDGYTPPVPAQGLGVREFKDYDLAELREYIDWQ 968 Query: 964 PFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAV- 1022 PFFNAWEMKGRFPDILNNPATGEAARKLY+DAQEMLDTLI+EKWLTANGVIGFFPANA Sbjct: 969 PFFNAWEMKGRFPDILNNPATGEAARKLYDDAQEMLDTLIKEKWLTANGVIGFFPANASP 1028 Query: 1023 -GDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTA 1081 GDDI VYTD+TR EVLTTLHNLRQQGEHR+GIPNRSLGDFIAPK++GL DY+GAFAVTA Sbjct: 1029 GGDDIVVYTDDTRTEVLTTLHNLRQQGEHRSGIPNRSLGDFIAPKESGLRDYIGAFAVTA 1088 Query: 1082 GLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEAL 1141 GLGSQ KI+EFK ALDDYSAILLES+ADRLAEAFAERMH+RVR+EFWGYQPDEQLDN+AL Sbjct: 1089 GLGSQDKIMEFKAALDDYSAILLESLADRLAEAFAERMHERVRKEFWGYQPDEQLDNDAL 1148 Query: 1142 IGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHP 1201 IGE+YVGIRPAPGYPACPEHTEK TL++LMDV +RTGIELTESMAMWPGAAVSGWYFSHP Sbjct: 1149 IGEKYVGIRPAPGYPACPEHTEKATLWKLMDVKERTGIELTESMAMWPGAAVSGWYFSHP 1208 Query: 1202 QSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 QSQYFVVGR+AQDQVADYAKRKGWTL EAERWL PNLGYNPED Sbjct: 1209 QSQYFVVGRLAQDQVADYAKRKGWTLAEAERWLAPNLGYNPED 1251 >tr|Q1B778|Q1B778_MYCSS Tax_Id=164756 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Mycobacterium sp.] Length = 1220 Score = 2271 bits (5884), Expect = 0.0 Identities = 1126/1220 (92%), Positives = 1176/1220 (96%) Query: 25 MVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIEGIHREYLQAGA 84 MVIDGAMGTAIQRDRPDEAGYRGERF +WP+ L GNNDLL+LTQPQIIE IHREYL+AGA Sbjct: 1 MVIDGAMGTAIQRDRPDEAGYRGERFTEWPTALQGNNDLLNLTQPQIIEAIHREYLEAGA 60 Query: 85 DILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFSTPEKPRYVAGALGPTTR 144 DILETNTFNANA+SL+DYDMA+L+YELNY DE+ST EKPRYVAGA+GPTTR Sbjct: 61 DILETNTFNANAISLADYDMADLSYELNYAGAALARKAADEYSTAEKPRYVAGAIGPTTR 120 Query: 145 TASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFDSLNAKAAVFAVET 204 TASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGAD+IIIETIFDSLNAKAAVFAVET Sbjct: 121 TASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADLIIIETIFDSLNAKAAVFAVET 180 Query: 205 LFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNCALGAPEMRPYI 264 LFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNCALGAPEMRPYI Sbjct: 181 LFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNCALGAPEMRPYI 240 Query: 265 AEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVNLVGGCCGTAPPHI 324 AEMARIADTFVSCYPNAGLPNAFGEYDE+PE QAGYIA+FA+AGLVNLVGGCCGTAPPHI Sbjct: 241 AEMARIADTFVSCYPNAGLPNAFGEYDESPERQAGYIADFAEAGLVNLVGGCCGTAPPHI 300 Query: 325 AEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNITGSARFRNLIKAE 384 AEIAK VEGK PRE+PEIPVATRLSGLEPLNI+DDSLFVNIGERTNITGSARFRNLIKAE Sbjct: 301 AEIAKAVEGKPPREVPEIPVATRLSGLEPLNITDDSLFVNIGERTNITGSARFRNLIKAE 360 Query: 385 DYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDISRVPVMIDSSKW 444 DYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDISRVPVMIDSSKW Sbjct: 361 DYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDISRVPVMIDSSKW 420 Query: 445 EVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAFDEKGQADNLERRK 504 EVIEAGLKNVQGKPIVNSISMKEGEEKF+REARLCRKYGAAVVVMAFDE+GQADNLERRK Sbjct: 421 EVIEAGLKNVQGKPIVNSISMKEGEEKFIREARLCRKYGAAVVVMAFDEQGQADNLERRK 480 Query: 505 EICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIKENLPGVHI 564 EICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIKENLPGVHI Sbjct: 481 EICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIKENLPGVHI 540 Query: 565 SGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPYDSIDPELRERIED 624 SGGISNVSFSFRGNNPVREAIH+VFLFHAIKAGLDMGIVNAGALVPYDSIDPELR+RIED Sbjct: 541 SGGISNVSFSFRGNNPVREAIHSVFLFHAIKAGLDMGIVNAGALVPYDSIDPELRDRIED 600 Query: 625 VVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPVRERITHALVKGIDAHVDADTE 684 VVLNRREDAAERLLEIAERFN K++DPAAAEWRSLPVRERITHALVKGIDAHVDADTE Sbjct: 601 VVLNRREDAAERLLEIAERFNKSEKADDPAAAEWRSLPVRERITHALVKGIDAHVDADTE 660 Query: 685 ELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFI 744 ELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLP+I Sbjct: 661 ELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPYI 720 Query: 745 EAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTVVDLGVMVPAEKIL 804 EAEK Q+G+T TNG IIMATVKGDVHDIGKNIVGVVLQCNN+ V+DLGVMVPA+KIL Sbjct: 721 EAEKEQNGTTASKDTNGTIIMATVKGDVHDIGKNIVGVVLQCNNFEVIDLGVMVPAQKIL 780 Query: 805 AAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGATTSRAHTAVKVAPRR 864 AA+E+DADIIGLSGLITPSLDEMVNFAA MEREG++IPLLIGGATTSRAHTAVKVAPRR Sbjct: 781 DAAKEHDADIIGLSGLITPSLDEMVNFAAEMEREGLEIPLLIGGATTSRAHTAVKVAPRR 840 Query: 865 SGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERHSQKNERPMLTLEKARA 924 SGPVVWVKDASRSVPVAAALLDDKQRP LLEATA DYA+LRERH+QKNERPMLTLEKARA Sbjct: 841 SGPVVWVKDASRSVPVAAALLDDKQRPALLEATAKDYASLRERHAQKNERPMLTLEKARA 900 Query: 925 NRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPAT 984 NRTPI+WDGYTPP+PAQG+GVREF DYDLAELREYIDWQPFFNAWEMKGRFPDILNNP + Sbjct: 901 NRTPIEWDGYTPPVPAQGVGVREFLDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPVS 960 Query: 985 GEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIEVYTDETRAEVLTTLHNL 1044 GEAARKLY+DAQEMLDTLI+EKWLTANGVIGFFPANAVGDDIEVYTD+TR EVLTTLHNL Sbjct: 961 GEAARKLYDDAQEMLDTLIKEKWLTANGVIGFFPANAVGDDIEVYTDDTRTEVLTTLHNL 1020 Query: 1045 RQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTKIVEFKEALDDYSAILL 1104 RQQGEHR GIPNRSLGDFIAP++TGL DYVGAFAVTAGLGSQ +IVEFK A DDYSAILL Sbjct: 1021 RQQGEHRDGIPNRSLGDFIAPRETGLRDYVGAFAVTAGLGSQDRIVEFKAANDDYSAILL 1080 Query: 1105 ESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYVGIRPAPGYPACPEHTEK 1164 ES+ADRLAEAFAERMHQRVR+EFWGYQPDEQLDNEALIGE+Y GIRPAPGYPACPEHTEK Sbjct: 1081 ESLADRLAEAFAERMHQRVRKEFWGYQPDEQLDNEALIGEKYSGIRPAPGYPACPEHTEK 1140 Query: 1165 TTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGRMAQDQVADYAKRKG 1224 TL+ELMDV +RTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGR+AQDQVADYAKRKG Sbjct: 1141 ATLWELMDVQERTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGRLAQDQVADYAKRKG 1200 Query: 1225 WTLPEAERWLGPNLGYNPED 1244 WTLPEAERWL PNLGYNPED Sbjct: 1201 WTLPEAERWLAPNLGYNPED 1220 >tr|A4TB79|A4TB79_MYCGI Tax_Id=350054 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Mycobacterium gilvum] Length = 1251 Score = 2264 bits (5867), Expect = 0.0 Identities = 1119/1241 (90%), Positives = 1180/1241 (95%) Query: 4 FEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDL 63 FEPNIRPDCT+ LTAAL +RIMVIDGAMGTAIQRDRPDEAGYRG+RF +WP+ L GNNDL Sbjct: 11 FEPNIRPDCTEELTAALRERIMVIDGAMGTAIQRDRPDEAGYRGDRFTEWPTALQGNNDL 70 Query: 64 LSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXX 123 L+LTQPQIIE IHREYL AGADILETNTFNANA+SLSDYDM +LAYELNY Sbjct: 71 LNLTQPQIIEAIHREYLDAGADILETNTFNANAISLSDYDMTDLAYELNYAGAALARKAA 130 Query: 124 DEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADI 183 DE+ST +KPRYVAGA+GPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG+D+ Sbjct: 131 DEYSTADKPRYVAGAIGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGSDL 190 Query: 184 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 243 I+IETIFDSLNAKAAVFAVETLFE+RGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH Sbjct: 191 IMIETIFDSLNAKAAVFAVETLFEERGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 250 Query: 244 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAE 303 AKP+AVGLNCALGAPEMRPYIAE+ARIADTFVSCYPNAGLPNAFGEYDE+PE QA YIAE Sbjct: 251 AKPLAVGLNCALGAPEMRPYIAEVARIADTFVSCYPNAGLPNAFGEYDESPERQASYIAE 310 Query: 304 FADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFV 363 FA+AGLVNLVGGCCGTAPPHIAEIAKVV+GK PRELP+IPVATRLSGLEPLNI+D+SLFV Sbjct: 311 FAEAGLVNLVGGCCGTAPPHIAEIAKVVDGKTPRELPQIPVATRLSGLEPLNINDESLFV 370 Query: 364 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 423 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT Sbjct: 371 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 430 Query: 424 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYG 483 KLIA+EPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKF+REA+LCRKYG Sbjct: 431 KLIASEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFIREAQLCRKYG 490 Query: 484 AAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT 543 AAVVVMAFDE+GQADNLERRKEICGRAYRILTE+VGFPAEDIIFDPNCFALATGIEEHAT Sbjct: 491 AAVVVMAFDEQGQADNLERRKEICGRAYRILTEKVGFPAEDIIFDPNCFALATGIEEHAT 550 Query: 544 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV 603 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV Sbjct: 551 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV 610 Query: 604 NAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPV 663 NAGALVPYDSIDPELR+RIEDVVLNRR DAAERLLEIAERFN K EDP AAEWRSLPV Sbjct: 611 NAGALVPYDSIDPELRDRIEDVVLNRRADAAERLLEIAERFNKADKGEDPQAAEWRSLPV 670 Query: 664 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 723 RERITHALVKGIDAHVD DTEELRAEI AAGGRPIEVIEGPLMDGMNVVGDLFG+GKMFL Sbjct: 671 RERITHALVKGIDAHVDDDTEELRAEIEAAGGRPIEVIEGPLMDGMNVVGDLFGSGKMFL 730 Query: 724 PQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVV 783 PQVVKSARVMKKAVAYLLP+IEAEKA +G+T TNG I+MATVKGDVHDIGKNIVGVV Sbjct: 731 PQVVKSARVMKKAVAYLLPYIEAEKADAGTTGSKDTNGTIVMATVKGDVHDIGKNIVGVV 790 Query: 784 LQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIP 843 LQCNN+ V+DLGVMVPA+KIL AARE+DADIIGLSGLITPSLDEM NFA MER G++IP Sbjct: 791 LQCNNFEVIDLGVMVPAQKILDAAREHDADIIGLSGLITPSLDEMSNFAVEMERAGLEIP 850 Query: 844 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAA 903 LLIGGATTSRAHTAVK++PRRSGPVVWVKDASRSVPVAAALLDDKQRP LLEAT DYA+ Sbjct: 851 LLIGGATTSRAHTAVKISPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATEKDYAS 910 Query: 904 LRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQ 963 LRERH+QKN+RPMLTLEKARANRTPI+WDGYTPP+PAQG+GVREF DYDLAELREYIDWQ Sbjct: 911 LRERHAQKNDRPMLTLEKARANRTPIEWDGYTPPVPAQGVGVREFIDYDLAELREYIDWQ 970 Query: 964 PFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVG 1023 PFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLI+EKWLTANGVIGFF ANAVG Sbjct: 971 PFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIKEKWLTANGVIGFFCANAVG 1030 Query: 1024 DDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGL 1083 DDIEVYTD+TR EVLTTL+NLRQQGEHR GIPNRS GDFIAPK+TGL DY+GAFAVTAGL Sbjct: 1031 DDIEVYTDDTRTEVLTTLYNLRQQGEHRDGIPNRSQGDFIAPKETGLRDYIGAFAVTAGL 1090 Query: 1084 GSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIG 1143 GSQ KI+EFK ALDDYSAILLES+ADRLAEAFAERMH+RVR EFWGYQPDEQLDN ALI Sbjct: 1091 GSQAKIMEFKAALDDYSAILLESLADRLAEAFAERMHERVRTEFWGYQPDEQLDNNALIA 1150 Query: 1144 ERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQS 1203 ERYVGIRPAPGYP+CPEHTEK TLF L+D T+RTGIELTESMAMWPGAAVSGWYFSHPQS Sbjct: 1151 ERYVGIRPAPGYPSCPEHTEKATLFGLLDATERTGIELTESMAMWPGAAVSGWYFSHPQS 1210 Query: 1204 QYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 QYFVVGR+AQDQVADYA+RKGWTL EAERWL PNLGYNPED Sbjct: 1211 QYFVVGRLAQDQVADYARRKGWTLQEAERWLAPNLGYNPED 1251 >tr|B1MPF9|B1MPF9_MYCA9 Tax_Id=561007 SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase MetH;[Mycobacterium abscessus] Length = 1253 Score = 2259 bits (5855), Expect = 0.0 Identities = 1123/1249 (89%), Positives = 1183/1249 (94%), Gaps = 9/1249 (0%) Query: 5 EPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLL 64 +PN+RPDCT+ALTAAL QRI+VIDGAMGTAIQRDRPDEAGYRGERF DWPSDLVGNNDLL Sbjct: 5 QPNVRPDCTEALTAALEQRILVIDGAMGTAIQRDRPDEAGYRGERFADWPSDLVGNNDLL 64 Query: 65 SLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXD 124 +LTQP IIEGIHREYL+AGADILETNTFNANAVSLSDY M EL+YELNY D Sbjct: 65 TLTQPHIIEGIHREYLEAGADILETNTFNANAVSLSDYGMEELSYELNYAGAALARVAAD 124 Query: 125 EFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADII 184 E+STP KPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADII Sbjct: 125 EYSTPAKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADII 184 Query: 185 IIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHA 244 ++ETIFDSLNAKAAVFA+ETLFE RGRRWP+IISGTITDASGRTLSGQVTEAFWNAIRHA Sbjct: 185 LVETIFDSLNAKAAVFAIETLFEQRGRRWPIIISGTITDASGRTLSGQVTEAFWNAIRHA 244 Query: 245 KPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEF 304 +PIAVGLNCALGAPEMRPYIAEM+RIADTFVSCYPNAGLPNAFGEYDE+PEHQAGY+AEF Sbjct: 245 RPIAVGLNCALGAPEMRPYIAEMSRIADTFVSCYPNAGLPNAFGEYDESPEHQAGYLAEF 304 Query: 305 ADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVN 364 A+AGLVNLVGGCCGTAP HIAEIAKVVEG PR++P I VATRLSGLEPLNI+DDSLFVN Sbjct: 305 AEAGLVNLVGGCCGTAPAHIAEIAKVVEGVKPRDVPSIDVATRLSGLEPLNITDDSLFVN 364 Query: 365 IGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTK 424 IGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTK Sbjct: 365 IGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTK 424 Query: 425 LIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGA 484 LIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKF+REARLCRKYGA Sbjct: 425 LIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFIREARLCRKYGA 484 Query: 485 AVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATY 544 AVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATY Sbjct: 485 AVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATY 544 Query: 545 GIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVN 604 GIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVN Sbjct: 545 GIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVN 604 Query: 605 AGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNT---KGKSEDPAAAEWRSL 661 AGALVPYDSID ELR+RIEDVVLNRR DAAERLLEIAERFN+ G +D AA EWRSL Sbjct: 605 AGALVPYDSIDSELRDRIEDVVLNRRADAAERLLEIAERFNSTENSGGGDDRAAQEWRSL 664 Query: 662 PVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKM 721 PVRERITHALVKGIDAHVD DTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFG+GKM Sbjct: 665 PVRERITHALVKGIDAHVDDDTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGSGKM 724 Query: 722 FLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDK---TNGIIIMATVKGDVHDIGKN 778 FLPQVVKSARVMKKAVAYLLPFIEAEK +G+ K TNG I+MATVKGDVHDIGKN Sbjct: 725 FLPQVVKSARVMKKAVAYLLPFIEAEKEDNGTAGDSKSKDTNGTIVMATVKGDVHDIGKN 784 Query: 779 IVGVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMERE 838 IVGVVLQCNN+ V+DLGVMVPA+KIL AA+E+DADIIGLSGLITPSLDEM NFA MERE Sbjct: 785 IVGVVLQCNNFEVIDLGVMVPAQKILDAAKEHDADIIGLSGLITPSLDEMANFAVEMERE 844 Query: 839 GMQIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATA 898 G++IPLLIGGATTSRAHTAVK++PRR GPVVWVKDASRSVPVAAALLDDKQRPGLLEAT Sbjct: 845 GLEIPLLIGGATTSRAHTAVKISPRRKGPVVWVKDASRSVPVAAALLDDKQRPGLLEATE 904 Query: 899 ADYAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELRE 958 DYA+LRERH+QKNERP LTLEKARANRTP++WDGYTPP+PAQGLGVREF DYDLAE+RE Sbjct: 905 KDYASLRERHAQKNERPTLTLEKARANRTPVEWDGYTPPVPAQGLGVREFLDYDLAEVRE 964 Query: 959 YIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFP 1018 YIDWQPFFNAWEMKGRFPDILNNPATGEAARKL++DAQ++LDTLI+EKWLTANGVIGFFP Sbjct: 965 YIDWQPFFNAWEMKGRFPDILNNPATGEAARKLHDDAQQILDTLIKEKWLTANGVIGFFP 1024 Query: 1019 ANAVG---DDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVG 1075 ANAVG +DIEVYTD+TR EVLTTLHNLRQQGEHR GIPNRSLGD+IAPK+TGL DY+G Sbjct: 1025 ANAVGPGFEDIEVYTDDTRTEVLTTLHNLRQQGEHRDGIPNRSLGDYIAPKETGLRDYIG 1084 Query: 1076 AFAVTAGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQ 1135 AFAVTAGLGSQ KI+EFK LDDYSAILLESIADRLAEAFAERMHQRVR EFWG+QPDEQ Sbjct: 1085 AFAVTAGLGSQDKIMEFKADLDDYSAILLESIADRLAEAFAERMHQRVRTEFWGFQPDEQ 1144 Query: 1136 LDNEALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSG 1195 LDNEALIGE+Y GIRPAPGYPACPEHTEK TLF+L+DVTKRTGIELTESMAMWPGAAVSG Sbjct: 1145 LDNEALIGEKYRGIRPAPGYPACPEHTEKVTLFDLLDVTKRTGIELTESMAMWPGAAVSG 1204 Query: 1196 WYFSHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 WYF+HPQSQYFVVGR+AQDQVADYAKRKGWTL EAERWLGPNLGYNPED Sbjct: 1205 WYFAHPQSQYFVVGRLAQDQVADYAKRKGWTLQEAERWLGPNLGYNPED 1253 >tr|C2AQ69|C2AQ69_TSUPA Tax_Id=521096 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Tsukamurella paurometabola DSM 20162] Length = 1243 Score = 2258 bits (5852), Expect = 0.0 Identities = 1121/1244 (90%), Positives = 1179/1244 (94%), Gaps = 1/1244 (0%) Query: 1 VSAFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGN 60 +S+FEPNIRPDCTD L A L +RIMVIDGAMGTAIQRDRPDE GYRGERFK+WP+ L GN Sbjct: 1 MSSFEPNIRPDCTDELAATLRRRIMVIDGAMGTAIQRDRPDEDGYRGERFKEWPTALQGN 60 Query: 61 NDLLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXX 120 NDLL+LTQPQIIEGIHREYL+AGADILETNTFNANA+SLSDYDM EL+YELN+ Sbjct: 61 NDLLNLTQPQIIEGIHREYLEAGADILETNTFNANAISLSDYDMGELSYELNFVGAALAR 120 Query: 121 XXXDEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGG 180 DEFST +KPRYVAGALGPTTRTASISP+VNDPGARNVSYDQLVAAYLEA NGLVDGG Sbjct: 121 KVCDEFSTADKPRYVAGALGPTTRTASISPEVNDPGARNVSYDQLVAAYLEAVNGLVDGG 180 Query: 181 ADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNA 240 +D+I+IETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITD SGRTLSGQVTEAFWNA Sbjct: 181 SDVILIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDGSGRTLSGQVTEAFWNA 240 Query: 241 IRHAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGY 300 IRHAKPIAVGLNCALGAPEMRPYIAEMARI+DTFVSCYPNAGLPNAFGEYDE+PEHQA Y Sbjct: 241 IRHAKPIAVGLNCALGAPEMRPYIAEMARISDTFVSCYPNAGLPNAFGEYDESPEHQAAY 300 Query: 301 IAEFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDS 360 +AEFA+AGLVNLVGGCCGTAP HIAEIA+VVEG PRE+P++ VATRLSGLEPLNI+ DS Sbjct: 301 LAEFAEAGLVNLVGGCCGTAPAHIAEIARVVEGTPPREIPQLSVATRLSGLEPLNITADS 360 Query: 361 LFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD 420 LFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD Sbjct: 361 LFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMD 420 Query: 421 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCR 480 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSIS+KEGEEKF+REARLCR Sbjct: 421 RFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISLKEGEEKFIREARLCR 480 Query: 481 KYGAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE 540 KYGAAVVVMAFDE+GQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE Sbjct: 481 KYGAAVVVMAFDEQGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEE 540 Query: 541 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM 600 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM Sbjct: 541 HATYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDM 600 Query: 601 GIVNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRS 660 GIVNAGALVPYD+IDPELR+RIEDVVLNRREDAAERLLEIAE+FN K+EDP AAEWR Sbjct: 601 GIVNAGALVPYDAIDPELRDRIEDVVLNRREDAAERLLEIAEQFNKSEKAEDPKAAEWRG 660 Query: 661 LPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGK 720 LPVRERITHALVKGIDA V+ DTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGK Sbjct: 661 LPVRERITHALVKGIDADVETDTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGK 720 Query: 721 MFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIV 780 MFLPQVVKSARVMKKAVAYLLP+IEAEK +SG+ +D TNG IIMATVKGDVHDIGKNIV Sbjct: 721 MFLPQVVKSARVMKKAVAYLLPYIEAEKDESGAASKD-TNGTIIMATVKGDVHDIGKNIV 779 Query: 781 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM 840 GVVLQCNNY V+DLGVMVPAEKILAAA+EYDADIIGLSGLITPSLDEMVNFA AMEREG+ Sbjct: 780 GVVLQCNNYEVIDLGVMVPAEKILAAAKEYDADIIGLSGLITPSLDEMVNFAVAMEREGL 839 Query: 841 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD 900 IPLLIGGATTSRAHTAVKV+PRRSGPVVWVKDASRSVPVAAALLDD+QRP LLEAT AD Sbjct: 840 DIPLLIGGATTSRAHTAVKVSPRRSGPVVWVKDASRSVPVAAALLDDRQRPALLEATEAD 899 Query: 901 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI 960 YAALRERH+QK+ERPMLTLEKARANRTPI+W YTPP+PAQGLGVREF DYDLAELREYI Sbjct: 900 YAALRERHAQKSERPMLTLEKARANRTPIEWAAYTPPVPAQGLGVREFLDYDLAELREYI 959 Query: 961 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN 1020 DWQPFFNAWEMKGRFPDILNNP +GE ARKLY+DAQ MLDTLI+EKWLTANGVIGFFPAN Sbjct: 960 DWQPFFNAWEMKGRFPDILNNPVSGETARKLYDDAQTMLDTLIKEKWLTANGVIGFFPAN 1019 Query: 1021 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT 1080 AVGDDIEVYTDETR +VLT LHNLRQQGEHR GIPNRSLGDF+APKDTGLADYVGAFAVT Sbjct: 1020 AVGDDIEVYTDETRTDVLTRLHNLRQQGEHRDGIPNRSLGDFVAPKDTGLADYVGAFAVT 1079 Query: 1081 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA 1140 GLGS KIVEFK A DDY+AILLES+ADRLAEAFAERMHQRVR EFWG+QPDE LDNEA Sbjct: 1080 TGLGSAAKIVEFKAANDDYNAILLESLADRLAEAFAERMHQRVRTEFWGFQPDEDLDNEA 1139 Query: 1141 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH 1200 LI E+YVGIRPAPGYPACPEHTEK TL+ELM+V +RTGIELTESMAMWPGAAVSGWYFSH Sbjct: 1140 LIDEKYVGIRPAPGYPACPEHTEKATLWELMNVHERTGIELTESMAMWPGAAVSGWYFSH 1199 Query: 1201 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 PQSQYFVVGR+AQDQVADYAKRKGWTL EAERWL PNLGYNPED Sbjct: 1200 PQSQYFVVGRLAQDQVADYAKRKGWTLQEAERWLSPNLGYNPED 1243 >tr|A0QF92|A0QF92_MYCA1 Tax_Id=243243 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Mycobacterium avium] Length = 1257 Score = 2256 bits (5847), Expect = 0.0 Identities = 1116/1246 (89%), Positives = 1183/1246 (94%), Gaps = 4/1246 (0%) Query: 3 AFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNND 62 +F PNIRPDCTD LTAAL QRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNND Sbjct: 12 SFAPNIRPDCTDELTAALRQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNND 71 Query: 63 LLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXX 122 LL+LTQPQIIEGIHREYL+AGADILETNTFNANA+SLSDY M EL+YELNY Sbjct: 72 LLNLTQPQIIEGIHREYLEAGADILETNTFNANAISLSDYGMEELSYELNYAGAALARKA 131 Query: 123 XDEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGAD 182 DEFSTP+KPRYVAGALGPT+RTASISPDVNDPGARNV+YD+LVAAYLEAANGLVDGG D Sbjct: 132 ADEFSTPDKPRYVAGALGPTSRTASISPDVNDPGARNVTYDELVAAYLEAANGLVDGGVD 191 Query: 183 IIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIR 242 ++I+ETIFD+LNAKAAVFA+ETLFE RGRRWPVIISGTITDASGRTLSGQVTEAFWN+IR Sbjct: 192 LLIVETIFDTLNAKAAVFALETLFEQRGRRWPVIISGTITDASGRTLSGQVTEAFWNSIR 251 Query: 243 HAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIA 302 HAKPIAVGLNCALGAPEMRPYIAE++RIADTFVSCYPNAGLPNAFGEYDE+PE QA YIA Sbjct: 252 HAKPIAVGLNCALGAPEMRPYIAEVSRIADTFVSCYPNAGLPNAFGEYDESPERQASYIA 311 Query: 303 EFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLF 362 +FA+AGLVN+VGGCCGTAPPHIAEIAKVVEGK PRE+P+IPVATRLSGLEPLNI+DDSLF Sbjct: 312 DFAEAGLVNIVGGCCGTAPPHIAEIAKVVEGKPPREVPQIPVATRLSGLEPLNITDDSLF 371 Query: 363 VNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRF 422 VNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRF Sbjct: 372 VNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRF 431 Query: 423 TKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKY 482 T+LIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSIS+KEGEEKFVREARLCRKY Sbjct: 432 TRLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISLKEGEEKFVREARLCRKY 491 Query: 483 GAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHA 542 GAAVVVMAFDE+GQADNLERRK+IC RAYR+LTEEVGFP EDIIFDPNCFALATGIEEHA Sbjct: 492 GAAVVVMAFDEQGQADNLERRKQICARAYRVLTEEVGFPPEDIIFDPNCFALATGIEEHA 551 Query: 543 TYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGI 602 TYGIDFIEACAWIKENLPGVH+SGGISNVSFSFRGNNPVREAIH+VFLFHAIKAGLDMGI Sbjct: 552 TYGIDFIEACAWIKENLPGVHLSGGISNVSFSFRGNNPVREAIHSVFLFHAIKAGLDMGI 611 Query: 603 VNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFN-TKGKSEDPAAAEWRSL 661 VNAGALVPYDSIDPELR+RIEDVVLNRREDAAERLLEIAERFN + SED AAAEWR L Sbjct: 612 VNAGALVPYDSIDPELRDRIEDVVLNRREDAAERLLEIAERFNKSADASEDSAAAEWRGL 671 Query: 662 PVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKM 721 PVRERITHALVKGIDAHVD DTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFG+GKM Sbjct: 672 PVRERITHALVKGIDAHVDEDTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGSGKM 731 Query: 722 FLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVG 781 FLPQVVKSARVMKKAVAYLLPFIEAEK +SG + TNG I+MATVKGDVHDIGKNIVG Sbjct: 732 FLPQVVKSARVMKKAVAYLLPFIEAEKEESGVSGSKDTNGTIVMATVKGDVHDIGKNIVG 791 Query: 782 VVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQ 841 VVLQCNN+ V+DLGVMVPA+KIL AA+E+DADIIGLSGLITPSLDEM NFAA MEREG+Q Sbjct: 792 VVLQCNNFEVIDLGVMVPAQKILDAAKEHDADIIGLSGLITPSLDEMSNFAAEMEREGLQ 851 Query: 842 IPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADY 901 IPLLIGGATTSRAHTAVK++PRRSGPVVWVKDASRSVPVAAALLDDKQRP LLEAT DY Sbjct: 852 IPLLIGGATTSRAHTAVKISPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATEKDY 911 Query: 902 AALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYID 961 A+LRERH+QKNERPM+TLEKARANRTPIDWDGYTPP+PA G G+REF DYDLAELREYID Sbjct: 912 ASLRERHAQKNERPMVTLEKARANRTPIDWDGYTPPVPAIGAGIREFQDYDLAELREYID 971 Query: 962 WQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANA 1021 WQPFFNAWEMKGRFPDILNNPATGEAARKLY+DAQEMLDTLI+EKWLTAN VIGFFPANA Sbjct: 972 WQPFFNAWEMKGRFPDILNNPATGEAARKLYDDAQEMLDTLIKEKWLTANAVIGFFPANA 1031 Query: 1022 VG---DDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFA 1078 +G +DIE+YTD+TR EVLTTLHNLRQQGEHR GIPNRSLGD++APK+TG DY+GAFA Sbjct: 1032 IGPGFEDIELYTDDTRTEVLTTLHNLRQQGEHRDGIPNRSLGDYVAPKETGHRDYIGAFA 1091 Query: 1079 VTAGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDN 1138 VTAGLGSQ KI EFK ALDDYSAILLESIADRLAEAFAERMHQRVR+EFWGYQPDEQLDN Sbjct: 1092 VTAGLGSQEKIAEFKAALDDYSAILLESIADRLAEAFAERMHQRVRKEFWGYQPDEQLDN 1151 Query: 1139 EALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYF 1198 +ALI E+Y GIRPAPGYPACPEHTEK TL++LMDV +RTGIELTESMAMWPGAAVSGWYF Sbjct: 1152 DALIDEKYRGIRPAPGYPACPEHTEKVTLWKLMDVKERTGIELTESMAMWPGAAVSGWYF 1211 Query: 1199 SHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 SHPQSQYFVVGR+AQDQVADYAKRKGWTL EAERWL PNLGYNPED Sbjct: 1212 SHPQSQYFVVGRLAQDQVADYAKRKGWTLAEAERWLAPNLGYNPED 1257 >tr|Q73YU6|Q73YU6_MYCPA Tax_Id=1770 (metH)SubName: Full=MetH;[Mycobacterium paratuberculosis] Length = 1262 Score = 2254 bits (5842), Expect = 0.0 Identities = 1117/1246 (89%), Positives = 1180/1246 (94%), Gaps = 4/1246 (0%) Query: 3 AFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNND 62 +F PNIRPDCTD LTAAL QRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNND Sbjct: 17 SFAPNIRPDCTDELTAALRQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNND 76 Query: 63 LLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXX 122 LL+LTQPQIIEGIHREYL+AGADILETNTFNANA+SLSDY M EL+YELNY Sbjct: 77 LLNLTQPQIIEGIHREYLEAGADILETNTFNANAISLSDYGMEELSYELNYAGAALARKA 136 Query: 123 XDEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGAD 182 DEFSTP+KPRYVAGALGPT+RTASISPDVNDPGARNV+YD+LVAAYLEAANGLVDGG D Sbjct: 137 ADEFSTPDKPRYVAGALGPTSRTASISPDVNDPGARNVTYDELVAAYLEAANGLVDGGVD 196 Query: 183 IIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIR 242 ++I+ETIFD+LNAKAAVFA+ETLFE RGRRWPVIISGTITDASGRTLSGQVTEAFWN+IR Sbjct: 197 LLIVETIFDTLNAKAAVFALETLFEQRGRRWPVIISGTITDASGRTLSGQVTEAFWNSIR 256 Query: 243 HAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIA 302 HAKPIAVGLNCALGAPEMRPYIAE++RIADTFVSCYPNAGLPNAFGEYDE+PE QA YIA Sbjct: 257 HAKPIAVGLNCALGAPEMRPYIAEVSRIADTFVSCYPNAGLPNAFGEYDESPERQASYIA 316 Query: 303 EFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLF 362 +F +AGLVNLVGGCCGTAPPHIAEIAKVVEGK PRE+P+IPVATRLSGLEPLNI+DDSLF Sbjct: 317 DFTEAGLVNLVGGCCGTAPPHIAEIAKVVEGKPPREVPQIPVATRLSGLEPLNITDDSLF 376 Query: 363 VNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRF 422 VNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRF Sbjct: 377 VNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRF 436 Query: 423 TKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKY 482 T+LIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSIS+KEGEEKFVREARLCRKY Sbjct: 437 TRLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISLKEGEEKFVREARLCRKY 496 Query: 483 GAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHA 542 GAAVVVMAFDE+GQADNLERRK+IC RAYR+LTEEVGFP EDIIFDPNCFALATGIEEHA Sbjct: 497 GAAVVVMAFDEQGQADNLERRKQICARAYRVLTEEVGFPPEDIIFDPNCFALATGIEEHA 556 Query: 543 TYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGI 602 TYGIDFIEACAWIKENLPGVH+SGGISNVSFSFRGNNPVREAIH+VFLFHAIKAGLDMGI Sbjct: 557 TYGIDFIEACAWIKENLPGVHLSGGISNVSFSFRGNNPVREAIHSVFLFHAIKAGLDMGI 616 Query: 603 VNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFN-TKGKSEDPAAAEWRSL 661 VNAGALVPYDSIDPELR+RIEDVVLNRREDAAERLLEIAERFN + SED AAAEWR L Sbjct: 617 VNAGALVPYDSIDPELRDRIEDVVLNRREDAAERLLEIAERFNKSADASEDSAAAEWRGL 676 Query: 662 PVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKM 721 PVRERITHALVKGIDAHVD DTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFG+GKM Sbjct: 677 PVRERITHALVKGIDAHVDEDTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGSGKM 736 Query: 722 FLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVG 781 FLPQVVKSARVMKKAVAYLLPFIEAEK +SG + TNG I+MATVKGDVHDIGKNIVG Sbjct: 737 FLPQVVKSARVMKKAVAYLLPFIEAEKEESGVSGSKDTNGTIVMATVKGDVHDIGKNIVG 796 Query: 782 VVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQ 841 VVLQCNN+ V+DLGVMVPA+KIL AA+E+DADIIGLSGLITPSLDEM NFAA MEREG+Q Sbjct: 797 VVLQCNNFEVIDLGVMVPAQKILDAAKEHDADIIGLSGLITPSLDEMSNFAAEMEREGLQ 856 Query: 842 IPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADY 901 IPLLIGGATTSRAHTAVK++PRRSGPVVWVKDASRSVPVAAALLDDKQRP LLEAT DY Sbjct: 857 IPLLIGGATTSRAHTAVKISPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATEKDY 916 Query: 902 AALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYID 961 A+LRERH+QKNERPM+TLEKARANRTPIDWDGYTPP+PA G G+REF DYDLAELREYID Sbjct: 917 ASLRERHAQKNERPMVTLEKARANRTPIDWDGYTPPVPAIGAGIREFQDYDLAELREYID 976 Query: 962 WQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANA 1021 WQPFFNAWEMKGRFPDILNNPATGEAARKLY+DAQEMLDTLI EKWLT N VIGFFPANA Sbjct: 977 WQPFFNAWEMKGRFPDILNNPATGEAARKLYDDAQEMLDTLIEEKWLTPNAVIGFFPANA 1036 Query: 1022 VG---DDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFA 1078 +G +DIE+YTD+TR EVLTTLHNLRQQGEHR GIPNRSLGDFIAPK+TG DY+GAFA Sbjct: 1037 IGPGFEDIELYTDDTRTEVLTTLHNLRQQGEHRDGIPNRSLGDFIAPKETGHRDYIGAFA 1096 Query: 1079 VTAGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDN 1138 VTAGLGSQ KI EFK ALDDYSAILLESIADRLAEAFAERMHQRVR+EFWGYQPDEQLDN Sbjct: 1097 VTAGLGSQEKIAEFKAALDDYSAILLESIADRLAEAFAERMHQRVRKEFWGYQPDEQLDN 1156 Query: 1139 EALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYF 1198 +ALI E+Y GIRPAPGYPACPEHTEK TL++LMDV +RTGIELTESMAMWPGAAVSGWYF Sbjct: 1157 DALIDEKYRGIRPAPGYPACPEHTEKVTLWKLMDVKERTGIELTESMAMWPGAAVSGWYF 1216 Query: 1199 SHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 SHPQSQYFVVGR+AQDQVADYAKRKGWTL EAERWL PNLGYNPED Sbjct: 1217 SHPQSQYFVVGRLAQDQVADYAKRKGWTLAEAERWLAPNLGYNPED 1262 >tr|A0QZX6|A0QZX6_MYCS2 Tax_Id=246196 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Mycobacterium smegmatis] Length = 1246 Score = 2251 bits (5833), Expect = 0.0 Identities = 1113/1239 (89%), Positives = 1174/1239 (94%), Gaps = 3/1239 (0%) Query: 6 PNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLS 65 PNIRPDCTDALTAAL QRI+VIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLL+ Sbjct: 11 PNIRPDCTDALTAALRQRILVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLN 70 Query: 66 LTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDE 125 LTQP IIE IHREYL AGAD+LETNTFNANAVSLSDY M ELAYELNY DE Sbjct: 71 LTQPHIIEAIHREYLDAGADLLETNTFNANAVSLSDYGMQELAYELNYAGAALARAACDE 130 Query: 126 FSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIII 185 +STP+KPRYVAGALGPTTRTASISPDVNDPGARNVSYDQL AYLEAA GLVDGGAD+II Sbjct: 131 YSTPDKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLAEAYLEAARGLVDGGADLII 190 Query: 186 IETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAK 245 +ETIFD+LNAKAA+FA+ETLFE+RGRRWPVIISGTITDASGRTLSGQVTEAFWN+IRHA+ Sbjct: 191 VETIFDTLNAKAAIFAIETLFEERGRRWPVIISGTITDASGRTLSGQVTEAFWNSIRHAQ 250 Query: 246 PIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFA 305 P+AVGLNCALGAPEMRPYIAEM+RIADTFVSCYPNAGLPNAFGEYDE+P+ QA Y+ EFA Sbjct: 251 PLAVGLNCALGAPEMRPYIAEMSRIADTFVSCYPNAGLPNAFGEYDESPKRQASYVEEFA 310 Query: 306 DAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNI 365 +AG VNLVGGCCGT P HIAEIAKVVEGK PR++PEIPVATRLSGLEPLNI +DSLFVNI Sbjct: 311 EAGFVNLVGGCCGTTPAHIAEIAKVVEGKPPRQVPEIPVATRLSGLEPLNIDEDSLFVNI 370 Query: 366 GERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKL 425 GERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKL Sbjct: 371 GERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKL 430 Query: 426 IAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAA 485 IA+EPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSIS+KEGEEKFVREARLCRKYGAA Sbjct: 431 IASEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISLKEGEEKFVREARLCRKYGAA 490 Query: 486 VVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYG 545 VVVMAFDE+GQADNLERRK+ICGRAY+ LTEEVGFPAEDIIFDPNCFALATGIEEHATYG Sbjct: 491 VVVMAFDEQGQADNLERRKQICGRAYKTLTEEVGFPAEDIIFDPNCFALATGIEEHATYG 550 Query: 546 IDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNA 605 IDFIEAC WIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNA Sbjct: 551 IDFIEACRWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNA 610 Query: 606 GALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPVRE 665 GALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFN+K K EDPAAAEWRSLPVRE Sbjct: 611 GALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNSKDKGEDPAAAEWRSLPVRE 670 Query: 666 RITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQ 725 RITHALVKGIDAHVD DTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFG+GKMFLPQ Sbjct: 671 RITHALVKGIDAHVDDDTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGSGKMFLPQ 730 Query: 726 VVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQ 785 VVKSARVMKKAVAYLLP+IEAEK + +++NG IIMATVKGDVHDIGKNIVGVVLQ Sbjct: 731 VVKSARVMKKAVAYLLPYIEAEKKPG---DAERSNGTIIMATVKGDVHDIGKNIVGVVLQ 787 Query: 786 CNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLL 845 CNNYTV+DLGVMVPA+KIL AA+E++ADIIGLSGLITPSLDEMVNFAA MEREGM IPLL Sbjct: 788 CNNYTVIDLGVMVPAQKILDAAKEHNADIIGLSGLITPSLDEMVNFAAEMEREGMDIPLL 847 Query: 846 IGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALR 905 IGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRP LLEAT DYA+LR Sbjct: 848 IGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATEKDYASLR 907 Query: 906 ERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPF 965 ERH+QKNERPM+TLEKARANRTPIDWDGYTPP+PAQGLG+REF +YDL+ELR+YIDWQPF Sbjct: 908 ERHAQKNERPMVTLEKARANRTPIDWDGYTPPVPAQGLGIREFENYDLSELRQYIDWQPF 967 Query: 966 FNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDD 1025 FNAWEMKG+FPDILNNPA+GEAARKLY +AQEMLDTLI+EKWLTANGVIGFFPANAVGDD Sbjct: 968 FNAWEMKGKFPDILNNPASGEAARKLYEEAQEMLDTLIKEKWLTANGVIGFFPANAVGDD 1027 Query: 1026 IEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGS 1085 IEVYTD+TR EVLTTL NLRQQGEHR GIPNRSLGDFIAPK+TGLADY+GAFAVTAGLGS Sbjct: 1028 IEVYTDDTRTEVLTTLRNLRQQGEHRDGIPNRSLGDFIAPKETGLADYIGAFAVTAGLGS 1087 Query: 1086 QTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGER 1145 KI EFK DDYSAILLES+ADRLAEAFAERMHQRVR E W YQPDE+LDNEALI ER Sbjct: 1088 AEKIAEFKADHDDYSAILLESLADRLAEAFAERMHQRVRTELWAYQPDEELDNEALIAER 1147 Query: 1146 YVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQY 1205 Y GIRPAPGYPACPEHTEK TLF+L+DVT+RTGIELTESMAMWPGAAVSGWYFSHPQSQY Sbjct: 1148 YRGIRPAPGYPACPEHTEKATLFKLLDVTERTGIELTESMAMWPGAAVSGWYFSHPQSQY 1207 Query: 1206 FVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 FVVGR+AQDQVADYA+RKGWTL EAERWL PNLGYNPED Sbjct: 1208 FVVGRLAQDQVADYARRKGWTLQEAERWLAPNLGYNPED 1246 >tr|A1SJZ9|A1SJZ9_NOCSJ Tax_Id=196162 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Nocardioides sp.] Length = 1244 Score = 1949 bits (5050), Expect = 0.0 Identities = 964/1244 (77%), Positives = 1074/1244 (86%), Gaps = 3/1244 (0%) Query: 3 AFEPNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNND 62 ++ P RPD TD LT AL QRI+V+DGAMGTAIQRDRPDEAGYRGERF DWPSDLVGNND Sbjct: 2 SWSPQQRPDLTDQLTRALEQRILVLDGAMGTAIQRDRPDEAGYRGERFADWPSDLVGNND 61 Query: 63 LLSLTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXX 122 LL++T+P+II GIHREYL AGADI+ETNTFNANAVSLSDY M ELAYE+NY Sbjct: 62 LLTITRPEIIAGIHREYLLAGADIIETNTFNANAVSLSDYGMQELAYEINYEAAQLARRE 121 Query: 123 XDEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGAD 182 D ST E PRYVAGALGPTTRTASISPDVNDPGARNV+YDQLVAAYL+AA GLVDGGAD Sbjct: 122 VDAVSTQEHPRYVAGALGPTTRTASISPDVNDPGARNVTYDQLVAAYLDAARGLVDGGAD 181 Query: 183 IIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIR 242 +++IETIFD+LNAKAA+FAVETLF + RRWPVIISGTITDASGRTLSGQVTEAFWN++R Sbjct: 182 LLVIETIFDTLNAKAAIFAVETLFAENQRRWPVIISGTITDASGRTLSGQVTEAFWNSVR 241 Query: 243 HAKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIA 302 HA+P+AVGLNCALGA EMRPYIAE+ARIADTFVSCYPNAGLPNAFGEYDE E A I Sbjct: 242 HARPLAVGLNCALGAKEMRPYIAEIARIADTFVSCYPNAGLPNAFGEYDEAAEETAAIIE 301 Query: 303 EFADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLF 362 EFA +G VNLVGGCCGT P H+A IAK VEGK R +PE+ A RL+GLEP ++D SLF Sbjct: 302 EFAASGFVNLVGGCCGTTPAHVAAIAKAVEGKTRRPVPELTPALRLAGLEPFAVTDKSLF 361 Query: 363 VNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRF 422 VN+GERTNITGSARFR LIK DYDTALSVA QQVE GAQVIDINMDEGMIDGVAAMDRF Sbjct: 362 VNVGERTNITGSARFRKLIKDGDYDTALSVAAQQVENGAQVIDINMDEGMIDGVAAMDRF 421 Query: 423 TKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKY 482 T+LIA+EPDISRVPVM+DSSKWEVI+AGLKN+QGKPIVNSISMKEGE+ F +ARLCR+Y Sbjct: 422 TRLIASEPDISRVPVMVDSSKWEVIQAGLKNIQGKPIVNSISMKEGEDTFREQARLCRQY 481 Query: 483 GAAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHA 542 GAA VVMAFDE GQADNLERRK IC RAYRIL +EVGFP EDIIFDPN FA+ATGIEEHA Sbjct: 482 GAAAVVMAFDEDGQADNLERRKAICERAYRILVDEVGFPPEDIIFDPNVFAVATGIEEHA 541 Query: 543 TYGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGI 602 +YG+DFIEA WIK+NLPG +SGGISNVSFSFRGNNPVREAIHAVFL+HAI AGLDMGI Sbjct: 542 SYGLDFIEATRWIKQNLPGAKVSGGISNVSFSFRGNNPVREAIHAVFLYHAIGAGLDMGI 601 Query: 603 VNAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAA-EWRSL 661 VNAGALV YD ++PELRERIEDV+LNRR DAAERLLEIAE N G++ + AAA EWR+L Sbjct: 602 VNAGALVVYDQVEPELRERIEDVILNRRPDAAERLLEIAEAHNRAGETTEAAAAEEWRAL 661 Query: 662 PVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKM 721 PV ERITHALVKGIDAHV+ DTEELR IAA GGRPIEVIEGPLMDGMNVVGDLFGAGKM Sbjct: 662 PVEERITHALVKGIDAHVEPDTEELRQLIAARGGRPIEVIEGPLMDGMNVVGDLFGAGKM 721 Query: 722 FLPQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDK-TNGIIIMATVKGDVHDIGKNIV 780 FLPQVVKSARVMKKAVAYL+PFIE EK + K TNG I+MATVKGDVHDIGKNIV Sbjct: 722 FLPQVVKSARVMKKAVAYLIPFIEQEKLDNPELATAKETNGTIVMATVKGDVHDIGKNIV 781 Query: 781 GVVLQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGM 840 GVVLQCNNY V+DLGVMVP +K+L A E AD +G+SGLITPSLDEMV AA M+R GM Sbjct: 782 GVVLQCNNYEVIDLGVMVPTQKLLDTALEVGADAVGVSGLITPSLDEMVGVAAEMQRRGM 841 Query: 841 QIPLLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAAD 900 +IPLL+GGATTSRAHTAVKV + GPVVWVKDASRSVP A LL+ QRP L+ D Sbjct: 842 EIPLLVGGATTSRAHTAVKVDGKYDGPVVWVKDASRSVPTLATLLNPAQRPRLMAEIKED 901 Query: 901 YAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYI 960 Y +LR RH+ K++RPMLTLE+AR NRTPIDW Y PP P + G+ DYDLAELR++I Sbjct: 902 YDSLRARHATKHDRPMLTLEQARDNRTPIDWSTYAPPAP-RTPGIHVLEDYDLAELRDFI 960 Query: 961 DWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPAN 1020 DWQPFFNAWE+KG+FPDILN+P TGE AR LY+DAQ MLD +I EKWL AN V G FPAN Sbjct: 961 DWQPFFNAWELKGKFPDILNSPTTGETARGLYDDAQAMLDRVIEEKWLRANAVFGLFPAN 1020 Query: 1021 AVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVT 1080 AVGDD+EVYTD++R EVLTTLHNLRQQG+HR GIPNRSLGDF+AP+ TGL D+VGAFAVT Sbjct: 1021 AVGDDVEVYTDDSRTEVLTTLHNLRQQGDHRDGIPNRSLGDFVAPRATGLPDHVGAFAVT 1080 Query: 1081 AGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEA 1140 AGLG++ +I+EFKE LDDYSAI+LE++ADRLAEAFAER+HQRVR EFW + P+E LDN+A Sbjct: 1081 AGLGAEARILEFKEQLDDYSAIMLEALADRLAEAFAERLHQRVRTEFWAHAPEEDLDNQA 1140 Query: 1141 LIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSH 1200 LI ERY GIRPAPGYPACPEHTEK TL+ L+DVT RTGIELT+ MAMWPGAAVSGWY+SH Sbjct: 1141 LIAERYDGIRPAPGYPACPEHTEKRTLWRLLDVTARTGIELTDGMAMWPGAAVSGWYYSH 1200 Query: 1201 PQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 PQSQYFV+GR+ +DQVADYA+RKGWTL EAERWL PNLGY+P+D Sbjct: 1201 PQSQYFVLGRIGRDQVADYAERKGWTLTEAERWLSPNLGYDPDD 1244 >tr|C0U0I5|C0U0I5_9ACTO Tax_Id=526225 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Geodermatophilus obscurus DSM 43160] Length = 1269 Score = 1840 bits (4767), Expect = 0.0 Identities = 915/1264 (72%), Positives = 1049/1264 (82%), Gaps = 28/1264 (2%) Query: 6 PNIRPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLS 65 P++RPD T LTA LGQRI+V+DGAMGTAIQRDRPDEAGYRGERF DWP+D+ GNNDLLS Sbjct: 8 PDLRPDATAELTAVLGQRILVLDGAMGTAIQRDRPDEAGYRGERFADWPTDVQGNNDLLS 67 Query: 66 LTQPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDE 125 +T+P+II GIHREYL+AGAD++ETNTFNA A+SL DY M++LAYE+N D Sbjct: 68 ITRPEIIAGIHREYLEAGADLVETNTFNATAISLRDYGMSDLAYEINVAAARLARAEADA 127 Query: 126 FS--TPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADI 183 + TP++PRYVAGALGPT+RTASISP+VNDPGARNV++D+L AYLE A+GLVDGG D+ Sbjct: 128 MTARTPDRPRYVAGALGPTSRTASISPNVNDPGARNVTFDELALAYLEQADGLVDGGVDV 187 Query: 184 IIIETIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRH 243 ++IET+FD+LNAKAA++A+ETLFE RGRRWPV++SGTITDASGRTLSGQVTEAFW++IRH Sbjct: 188 LLIETVFDTLNAKAAIYALETLFEQRGRRWPVMVSGTITDASGRTLSGQVTEAFWHSIRH 247 Query: 244 AKPIAVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAE 303 +P+ VGLNCALGA EMRPY+AE++R+ADT+VSCYPNAGLPNAFGEYDE+PE A +AE Sbjct: 248 VRPLLVGLNCALGAAEMRPYLAELSRVADTYVSCYPNAGLPNAFGEYDESPEETAAVLAE 307 Query: 304 FADAGLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFV 363 FADAG VN VGGCCGT P HIA IA VEG+APR P + A RLSGLEPL + +DSLFV Sbjct: 308 FADAGFVNTVGGCCGTTPAHIAVIAATVEGRAPRTPPRVRPALRLSGLEPLVVDEDSLFV 367 Query: 364 NIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFT 423 N+GERTNITGSARFRNLI+A DY TAL+VA QQVE GAQVID+NMDEGMIDGV AMDRF Sbjct: 368 NVGERTNITGSARFRNLIRAGDYPTALAVARQQVEAGAQVIDVNMDEGMIDGVEAMDRFL 427 Query: 424 KLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYG 483 KL+AAEPDI RVPVM+DSSKWEVIEAGLK VQGK IVNSIS+K GEE+FV++ARLCRK+G Sbjct: 428 KLVAAEPDICRVPVMVDSSKWEVIEAGLKCVQGKSIVNSISLKAGEEEFVQQARLCRKHG 487 Query: 484 AAVVVMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHAT 543 AAVVVMAFDE+GQAD+L+RR+EIC RAY IL E+VGFPAED+IFDPN FA+ATGIEEHA Sbjct: 488 AAVVVMAFDEQGQADSLQRRQEICRRAYDILVEQVGFPAEDVIFDPNVFAVATGIEEHAR 547 Query: 544 YGIDFIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIV 603 YG+DFIEA WIK++LPG +SGG+SNVSFSFRGNN VREAIHAVFLFHAI AG++MGIV Sbjct: 548 YGLDFIEATRWIKQHLPGALVSGGVSNVSFSFRGNNRVREAIHAVFLFHAIAAGMNMGIV 607 Query: 604 NAGALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPV 663 NAGAL YD + LRERIEDVVL RR DA ERLLEIA + G ++ A+ EWRSLPV Sbjct: 608 NAGALEVYDEVPERLRERIEDVVLARRPDATERLLEIAAEYAGDGAQKEVASEEWRSLPV 667 Query: 664 RERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFL 723 ERI HALVKGID V+ADTEELRA+IAA GGRPIEVIEGPLM GMNVVGDLFGAGKMFL Sbjct: 668 EERIAHALVKGIDGFVEADTEELRAQIAARGGRPIEVIEGPLMGGMNVVGDLFGAGKMFL 727 Query: 724 PQVVKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVV 783 PQVVKSARVMKKAVAYL+PFIEAEK Q G E ++NG ++MATVKGDVHDIGKNIVGVV Sbjct: 728 PQVVKSARVMKKAVAYLVPFIEAEK-QPGDVE--RSNGKVVMATVKGDVHDIGKNIVGVV 784 Query: 784 LQCNNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIP 843 LQCNNY VVDLGVMVPA+K+L A++ AD+IGLSGLITPSLDEM N AA MER+G IP Sbjct: 785 LQCNNYDVVDLGVMVPAQKVLDTAKQEGADVIGLSGLITPSLDEMSNLAAEMERQGFDIP 844 Query: 844 LLIGGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAA 903 LLIGGATTSRAHTAVKVAPR GPV+WVKDASRSVPV AALL ++QRP LL +YA Sbjct: 845 LLIGGATTSRAHTAVKVAPRYHGPVIWVKDASRSVPVVAALLSNEQRPKLLADVETEYAG 904 Query: 904 LRERHSQKNE-RPMLTLEKARANRTPIDWDGYTPPLPAQGLG------------------ 944 LRERH+ + + R +L LE ARA P+DW Y PP P L Sbjct: 905 LRERHAARQDTRALLPLEAARAAAPPVDWSSYAPPRPRMLLQQARDVCSGADCDHLHGRA 964 Query: 945 ---VREFHDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDT 1001 R DY L ELR Y+DWQPFFNAWEM+GRFPDIL+NPATGEAAR+LY DAQEMLD Sbjct: 965 TQFTRVLDDYPLEELRRYVDWQPFFNAWEMRGRFPDILHNPATGEAARRLYEDAQEMLDR 1024 Query: 1002 LIREKWLTANGVIGFFPANAV-GDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLG 1060 ++ E+WL A GV G FPAN V G+DIEVYTDE+R V TTLH LRQQ + R G P +SL Sbjct: 1025 VVAERWLQARGVFGLFPANRVDGEDIEVYTDESRTTVRTTLHQLRQQTQGRDGSPRKSLA 1084 Query: 1061 DFIAPKDTGLADYVGAFAVTAGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMH 1120 DF+APK+TGL DYVGAFAVTAGLGS ++ FK A DDYSAI+LE++ADRLAEAFAER+H Sbjct: 1085 DFVAPKETGLRDYVGAFAVTAGLGSAERVAAFKAANDDYSAIMLEALADRLAEAFAERLH 1144 Query: 1121 QRVREEFWGYQPDEQLDNEALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIE 1180 +RVR EFWGY DE LDN+ALI E+Y GIRPAPGYPACPEHTEK T++EL+DV TGI Sbjct: 1145 ERVRREFWGYAADEHLDNDALIAEQYRGIRPAPGYPACPEHTEKRTIWELLDVEATTGIT 1204 Query: 1181 LTESMAMWPGAAVSGWYFSHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGY 1240 LTESMAMWPGAAVSG Y +HPQS+YFV+GR+ +DQV DYA+RKGWTL EAERWL PNLGY Sbjct: 1205 LTESMAMWPGAAVSGLYLAHPQSRYFVLGRLGRDQVEDYARRKGWTLAEAERWLSPNLGY 1264 Query: 1241 NPED 1244 +D Sbjct: 1265 RTDD 1268 >tr|A3TL58|A3TL58_9MICO Tax_Id=313589 SubName: Full=MetH;[Janibacter sp. HTCC2649] Length = 1266 Score = 1798 bits (4657), Expect = 0.0 Identities = 908/1260 (72%), Positives = 1020/1260 (80%), Gaps = 25/1260 (1%) Query: 9 RPDCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQ 68 RPD T ALTAAL +R++V+DGAMGT IQR+ E YRGERF DWPSDL GNNDLLSLT Sbjct: 8 RPDATAALTAALTERVLVLDGAMGTMIQREGLSEEDYRGERFADWPSDLRGNNDLLSLTN 67 Query: 69 PQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFST 128 P IIEGIHR YL AGAD++ETNTFNA +SL+DYDMA++AYE+N DE + Sbjct: 68 PSIIEGIHRAYLLAGADLVETNTFNAQRISLADYDMADIAYEMNLEAARLARRACDEVAA 127 Query: 129 PE-KPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIE 187 +PR+V GALGPTTRTASISPDVNDPGARNVS+DQLV AYLE A GLVDGGAD +IIE Sbjct: 128 ETGRPRWVMGALGPTTRTASISPDVNDPGARNVSFDQLVEAYLEQARGLVDGGADALIIE 187 Query: 188 TIFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPI 247 TIFD+LNAKAA+FAVETLF+D GRRWPVIISGTITDASGRTLSGQVTEAFWN++RHA+P+ Sbjct: 188 TIFDTLNAKAAIFAVETLFDDLGRRWPVIISGTITDASGRTLSGQVTEAFWNSVRHARPL 247 Query: 248 AVGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADA 307 VGLNCALG E+RPYIAE++RIA FVS YPNAGLPNAFGEYDETP+ A + EFA + Sbjct: 248 VVGLNCALGPDELRPYIAELSRIAGCFVSAYPNAGLPNAFGEYDETPDQMASVVGEFATS 307 Query: 308 GLVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGE 367 GLVN++GGCCGT P HI IA+ PR E+P A RLSGLEPL + + SLFVN+GE Sbjct: 308 GLVNILGGCCGTTPEHIEAIAEAAAKGNPRVPSEVPGALRLSGLEPLTVDESSLFVNVGE 367 Query: 368 RTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIA 427 RTNITGSARFR LIK EDY ALSVA QQVE GAQVIDINMDEGMIDGVAAMDRF KLI Sbjct: 368 RTNITGSARFRRLIKEEDYPAALSVARQQVEAGAQVIDINMDEGMIDGVAAMDRFVKLIG 427 Query: 428 AEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVV 487 +EPDI RVP+MIDSSKWEVIEAGLK QGKPIVNSISMKEG E F+ ARLC KYGAAVV Sbjct: 428 SEPDICRVPLMIDSSKWEVIEAGLKCSQGKPIVNSISMKEGVEPFLEHARLCHKYGAAVV 487 Query: 488 VMAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGID 547 VMAFDE+GQAD+LERRK IC RAY +LT+EVG DIIFDPN FA+ATGIEEHA YG D Sbjct: 488 VMAFDEEGQADSLERRKVICQRAYDLLTQEVGMDPHDIIFDPNIFAVATGIEEHAAYGTD 547 Query: 548 FIEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGA 607 FIEA WIKENLPG +SGG+SNVSFSFRGNNPVREAIHAVFL++AI+AG+DMGIVNAGA Sbjct: 548 FIEATRWIKENLPGALVSGGVSNVSFSFRGNNPVREAIHAVFLYNAIQAGMDMGIVNAGA 607 Query: 608 LVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGK-SEDPAAAEWRSLPVRER 666 LV D +DPELRERIEDVVLNRR D+ ERL+EIA+RFN G+ + + AEWR LPVRER Sbjct: 608 LVVLDDVDPELRERIEDVVLNRRPDSTERLVEIADRFNNTGEAAPEVTEAEWRGLPVRER 667 Query: 667 ITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQV 726 ITH+LVKGID V DTE LR EI AA G+PIEVIEGPLMDGM VVGDLFGAGKMFLPQV Sbjct: 668 ITHSLVKGIDDFVVEDTELLRQEIEAADGKPIEVIEGPLMDGMGVVGDLFGAGKMFLPQV 727 Query: 727 VKSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQC 786 VKSARVMKKAVA+L+P+IEAEK +SG + Q+ + G+I+MATVKGDVHDIGKNIVGVVLQC Sbjct: 728 VKSARVMKKAVAHLIPYIEAEKERSGVSTQN-SKGLIVMATVKGDVHDIGKNIVGVVLQC 786 Query: 787 NNYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLI 846 NNY V+DLGVMVP +KIL A+E ADIIGLSGLITPSLDEMV A MER+G IPLLI Sbjct: 787 NNYDVIDLGVMVPTQKILDTAKEKGADIIGLSGLITPSLDEMVRVAQEMERQGFTIPLLI 846 Query: 847 GGATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRE 906 GGATTSRAHTAVKV + SGPVVWVKDASRSVPVA+ LL QR LL+ ADY ++R Sbjct: 847 GGATTSRAHTAVKVDGQYSGPVVWVKDASRSVPVASQLLSATQREPLLQTIKADYDSMRA 906 Query: 907 RHSQKN-ERPMLTLEKARANRTPIDWDGYTPPLP---------------------AQGLG 944 RH+ K+ ERP+++++ AR TPIDW Y P P A Sbjct: 907 RHAAKSTERPLVSIDAARKAHTPIDWTAYRPVRPHLLAQQSKDVWSGKADTKWHRAAAQF 966 Query: 945 VREFHDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIR 1004 REF Y + ELR YIDW PFF AWEMKGR+PDIL+NPATGE ARKL+ DA MLD +I Sbjct: 967 TREFISYPIEELRRYIDWTPFFQAWEMKGRYPDILSNPATGETARKLFEDANAMLDRIIE 1026 Query: 1005 EKWLTANGVIGFFPANAVGDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIA 1064 EKWLTA VIG FPANAVGDDIEVY DE+R VLTT+H LRQQG+HR G+PNR L DFIA Sbjct: 1027 EKWLTAKAVIGLFPANAVGDDIEVYADESRETVLTTIHGLRQQGQHREGVPNRCLSDFIA 1086 Query: 1065 PKDTGLADYVGAFAVTAGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVR 1124 PK+TGL DYVG FAVTAG G+ +I F+E LDDYS ILLE++ADRLAEAFAER+H+RVR Sbjct: 1087 PKETGLRDYVGGFAVTAGHGTHERIKAFQEELDDYSGILLEALADRLAEAFAERLHERVR 1146 Query: 1125 EEFWGYQPDEQLDNEALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTES 1184 EFWG+ DE L NE LI E+Y GIRPAPGYPACP+HTEK TLF+L+ +R G+ELTES Sbjct: 1147 REFWGHAGDEHLSNEDLISEKYAGIRPAPGYPACPDHTEKETLFKLLGAAERAGMELTES 1206 Query: 1185 MAMWPGAAVSGWYFSHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 MAM PGA+VSGWYFSHPQSQYFVVGR+ +DQV DYA RKGWTL EAERWLGPNLGY PED Sbjct: 1207 MAMQPGASVSGWYFSHPQSQYFVVGRLGRDQVEDYAARKGWTLAEAERWLGPNLGYQPED 1266 >tr|B9ZN58|B9ZN58_9GAMM Tax_Id=396595 SubName: Full=Methionine synthase;[Thioalkalivibrio sp. K90mix] Length = 1302 Score = 1569 bits (4063), Expect = 0.0 Identities = 784/1248 (62%), Positives = 962/1248 (77%), Gaps = 32/1248 (2%) Query: 19 ALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIEGIHRE 78 AL +RI+++DG MGT IQ + +EA YRGERFKDW SDL GNNDLLSLT+P IIE IH + Sbjct: 50 ALKERILILDGGMGTTIQLYKLEEADYRGERFKDWESDLKGNNDLLSLTRPDIIEQIHND 109 Query: 79 YLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEKPRYVA 136 YL+AGADI+E NTFN ++++DY M +L ELN D ++ TP+KPRYVA Sbjct: 110 YLEAGADIIEANTFNGTRIAMADYHMEDLVPELNRESAKLARKAADAWTEKTPDKPRYVA 169 Query: 137 GALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFDSLNAK 196 G LGPT RTASISPDVNDPGARNV +D LV +Y EAA LV+GG DI++IET+FD+LNAK Sbjct: 170 GILGPTNRTASISPDVNDPGARNVDFDTLVESYKEAAEALVEGGVDILLIETVFDTLNAK 229 Query: 197 AAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNCALG 256 AA+FAV+TL ++ G+ P++ISGTITDASGRTLSGQ TEAFWN++RHA P+++GLNCALG Sbjct: 230 AAIFAVKTLEDELGKELPIMISGTITDASGRTLSGQTTEAFWNSVRHANPVSIGLNCALG 289 Query: 257 APEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVNLVGGC 316 A EMR Y+ E++RIADT VS +PNAGLPN FG+YDE+PE A + +A+ GL+N++GGC Sbjct: 290 AKEMRQYVEELSRIADTHVSAHPNAGLPNEFGDYDESPEQMAADVGPWAEQGLLNIIGGC 349 Query: 317 CGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNITGSAR 376 CGT P HI + + VE PR++PEI A RLSGLEP NI+DDSLFVN+GERTN+TGS + Sbjct: 350 CGTLPEHIRAMREAVEKFPPRKVPEIAPACRLSGLEPCNITDDSLFVNVGERTNVTGSRK 409 Query: 377 FRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDISRVP 436 F LI+ E+YD AL VAL QVE GAQ+IDINMDEGM++ AM RF L+A EPDI+RVP Sbjct: 410 FLRLIQNEEYDVALEVALNQVEGGAQIIDINMDEGMLESQDAMVRFLNLLAGEPDIARVP 469 Query: 437 VMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAFDEKGQ 496 VMIDSSK+E+IEAGLK VQGK +VNSISMKEGEE F+++A+LCR+YGAA+VVMAFDE GQ Sbjct: 470 VMIDSSKFEIIEAGLKCVQGKAVVNSISMKEGEENFIKQAQLCRRYGAAIVVMAFDEDGQ 529 Query: 497 ADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIK 556 ADN +RR EIC RAYR+LTE+VGFPAEDIIFDPN FA+ATGIEEH YG+DFIEA IK Sbjct: 530 ADNEDRRVEICTRAYRLLTEKVGFPAEDIIFDPNIFAVATGIEEHNNYGVDFIEATRRIK 589 Query: 557 ENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPYDSIDP 616 ++LP +SGG+SNVSFSFRGN PVREAIHAVFL+HAIKAG+DMGIVNAG L YD ID Sbjct: 590 QDLPHALVSGGVSNVSFSFRGNEPVREAIHAVFLYHAIKAGMDMGIVNAGQLAVYDDIDE 649 Query: 617 ELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPVRERITHALVKGID 676 +L+E +EDVVLNRR+DA ERLL+++E + +G + EWR V +R+ H+LVKGID Sbjct: 650 KLKEAVEDVVLNRRDDATERLLDLSEEYKGQGGGKKEENLEWREWEVTKRLEHSLVKGID 709 Query: 677 AHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKA 736 +V DTEE R + RPI+VIEGPLMDGMNVVGDLFG GKMFLPQVVKSARVMKKA Sbjct: 710 TYVVEDTEEARQQY----DRPIQVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKKA 765 Query: 737 VAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTVVDLGV 796 VA+L+P+IEAEK + + NG I+MATVKGDVHDIGKNIVGVVLQCNN+ V+D+GV Sbjct: 766 VAHLIPYIEAEKTGT------ENNGKILMATVKGDVHDIGKNIVGVVLQCNNFEVIDIGV 819 Query: 797 MVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGATTSRAHT 856 M P +IL AA+E+D D+IGLSGLITPSL+EM NFAA +EREGM PL+IGGATTSRAHT Sbjct: 820 MQPGAEILKAAKEHDVDVIGLSGLITPSLEEMANFAADLEREGMTTPLMIGGATTSRAHT 879 Query: 857 AVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERHS-QKNERP 915 AVK+ P SGPVVWVKDASR+V VA +L+ + R +Y LR +++ +K + Sbjct: 880 AVKIEPNYSGPVVWVKDASRAVGVAQSLISPELRENYAAEIREEYEKLRVQNAGRKKKTQ 939 Query: 916 MLTLEKARANRTPIDWDGYTPPLP------------------AQGLGVREFHDYDLAELR 957 +TLEKARAN+ IDW YTP P G + F D+DL E+R Sbjct: 940 WVTLEKARANKPQIDWSSYTPTKPKALETDKLPGEPKVLHPHGDGSVLLRFDDFDLNEVR 999 Query: 958 EYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFF 1017 +IDW PFF++W++ +P IL++ GE ARKL+ D QEMLD +I EKW+T GV+GFF Sbjct: 1000 NFIDWTPFFHSWQLHAAYPRILDDEKVGEEARKLFKDGQEMLDRMIEEKWVTLRGVVGFF 1059 Query: 1018 PANAVG-DDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGA 1076 PAN V DDIEVYTDE+R++VL LH+LRQQ E R G P+ SL DF+ PK+ G DY+GA Sbjct: 1060 PANTVNDDDIEVYTDESRSKVLKKLHHLRQQTEKRRGQPSHSLADFLMPKEAGGPDYLGA 1119 Query: 1077 FAVTAGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQL 1136 FAV+AG K E+++A DDY AIL++S+ADRLAEAFAE MHQ VR+ +WGY PDE L Sbjct: 1120 FAVSAGGDVDAKAEEYEKANDDYHAILVKSLADRLAEAFAECMHQYVRKHYWGYVPDEAL 1179 Query: 1137 DNEALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGW 1196 +NE LI E+Y GIRPAPGYPACPEHTEK TL+EL+ + + LTES AM P +AVSGW Sbjct: 1180 ENEDLIDEKYQGIRPAPGYPACPEHTEKGTLWELLQADEHADMTLTESYAMLPVSAVSGW 1239 Query: 1197 YFSHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 YF+HP+S+YF +G++ +DQV DYAKRKG + EAERWL PN+GY+ D Sbjct: 1240 YFAHPESRYFGLGKVNRDQVEDYAKRKGMSFEEAERWLAPNIGYDDSD 1287 >tr|B8GLZ0|B8GLZ0_THISH Tax_Id=396588 SubName: Full=Methionine synthase;[Thioalkalivibrio sp.] Length = 1250 Score = 1564 bits (4050), Expect = 0.0 Identities = 797/1256 (63%), Positives = 955/1256 (76%), Gaps = 31/1256 (2%) Query: 11 DCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQ 70 D T L + +RI+++DGAMGT IQ EA YRGERF DW DL GNNDLL+LT+P+ Sbjct: 4 DRTRLLETHIKERILILDGAMGTMIQGYGLGEADYRGERFADWQIDLKGNNDLLALTRPE 63 Query: 71 IIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--T 128 II IH +YL+AGADILETNTFNA ++++DY M EL E+N DE++ T Sbjct: 64 IIAEIHGQYLEAGADILETNTFNATTIAMADYAMEELVPEINREAARLARRVADEWTAKT 123 Query: 129 PEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIET 188 P++PR+VAG LGPT RTASISPDVNDPG RNV +DQLVAAY +AA L++GGAD+++IET Sbjct: 124 PDRPRFVAGVLGPTNRTASISPDVNDPGFRNVDFDQLVAAYRQAAEALIEGGADLLLIET 183 Query: 189 IFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIA 248 +FD+LNAKAAVFAVE+LF++ GRR PV+ISGTITDASGRTLSGQ EAFWN++RHA+P + Sbjct: 184 VFDTLNAKAAVFAVESLFDETGRRLPVMISGTITDASGRTLSGQTAEAFWNSLRHARPFS 243 Query: 249 VGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAG 308 GLNCALG E+R ++ E++RIA+T VS +PNAGLPN FG YD +P A +I E+A++G Sbjct: 244 FGLNCALGPRELRAHVEEISRIANTHVSAHPNAGLPNEFGGYDLSPADMAVHIREWAESG 303 Query: 309 LVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGER 368 +N+VGGCCGT P HI IA+ V PR +P+ A RLSGLEP NI++DSLFVN+GER Sbjct: 304 FLNIVGGCCGTTPAHIRAIAEAVADLPPRSIPKREPACRLSGLEPCNITEDSLFVNVGER 363 Query: 369 TNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAA 428 TN+TGSARF+ LIK DY+TAL VA QVE GAQ+ID+NMDEGM+D AAM RF L+AA Sbjct: 364 TNVTGSARFKRLIKDGDYETALEVAASQVENGAQIIDVNMDEGMLDSKAAMVRFLNLMAA 423 Query: 429 EPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVV 488 EPDISRVPVMIDSSKWEVIEAGLK +QGK +VNSIS+KEGE F+ A+L R+YGAAV+V Sbjct: 424 EPDISRVPVMIDSSKWEVIEAGLKCIQGKGVVNSISLKEGEATFIEHAKLVRRYGAAVIV 483 Query: 489 MAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDF 548 MAFDE+GQAD R+ EIC RAYRILTE+V FPAEDIIFDPN FA+ATGIEEH YG+DF Sbjct: 484 MAFDEQGQADTQARKVEICERAYRILTEQVCFPAEDIIFDPNIFAIATGIEEHNNYGVDF 543 Query: 549 IEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGAL 608 IEA IK+ LP +SGG+SNVSFSFRGN PVREAIHAVFL+HAI AG+DMGIVNAG L Sbjct: 544 IEATREIKKRLPHALVSGGVSNVSFSFRGNEPVREAIHAVFLYHAIHAGMDMGIVNAGQL 603 Query: 609 VPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAAAEWRSLPVRERIT 668 YD ID ELRE +EDVVLNRR DA ERLLE AER+ +G EWR LPV +R+ Sbjct: 604 AVYDEIDRELRELVEDVVLNRRPDATERLLEAAERYRGEGGEAKKEDLEWRKLPVAKRLE 663 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 HALVKGIDA V DTEE R + PI VIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 664 HALVKGIDAFVVEDTEEARQGV----DHPIHVIEGPLMDGMNVVGDLFGDGKMFLPQVVK 719 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMKKAVA+L+PFIEA K E D+ NG ++MATVKGDVHDIGKNIVGVVLQCNN Sbjct: 720 SARVMKKAVAHLIPFIEALK-----QEGDRPNGKVLMATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 + V+DLGVMVPA+KIL A E D D+IGLSGLITPSL+EM + A M+R GM++PLLIGG Sbjct: 775 FEVIDLGVMVPAQKILDTAVEQDVDVIGLSGLITPSLEEMAHMAKEMQRLGMKLPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTSRAHTAVK+ P GP VWVKDASR+V V +L+ R + A+Y +R H Sbjct: 835 ATTSRAHTAVKIEPHYEGPTVWVKDASRAVGVVQSLISQNTREEYVAKIRAEYEEVRRHH 894 Query: 909 SQK-NERPMLTLEKARANRTPIDWDGYTPPLP----AQGLG--------------VREFH 949 +++ E+ LTL +AR NRTPIDW GY PP P A+ G V F Sbjct: 895 AERQKEQKWLTLAQARDNRTPIDWQGYQPPRPRALEAEPAGPGITVLHPFGPDSVVIRFD 954 Query: 950 DYDLAELREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLT 1009 DY L +L +YIDW PFF+AW++ +P I ++ GE A+KL+ DA+ ML+T+IRE WL Sbjct: 955 DYPLEDLLDYIDWTPFFHAWQLHAAYPRIFDDEVVGEEAKKLFADARVMLETIIREGWLK 1014 Query: 1010 ANGVIGFFPANAV-GDDIEVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDT 1068 A GVIGFFPAN+V DDIE+Y DE R L LH+LRQQ E R PN+ L DFIAP++T Sbjct: 1015 ARGVIGFFPANSVDADDIELYRDEDRTAPLMRLHHLRQQTERRGKGPNQCLADFIAPRET 1074 Query: 1069 GLADYVGAFAVTAGLGSQTKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFW 1128 GL DY+G FAVTAG+G + F++A DDY AI+L+++ADRLAEA AERMH+RVR EFW Sbjct: 1075 GLPDYLGGFAVTAGIGIDEHVRRFEQAHDDYHAIMLKALADRLAEALAERMHERVRREFW 1134 Query: 1129 GYQPDEQLDNEALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMW 1188 GY DE+LDNEALI E+Y GIRPAPGYPACPEHTEK L+EL+ + G+ +TES AM Sbjct: 1135 GYASDERLDNEALIKEQYRGIRPAPGYPACPEHTEKGLLWELLKPEENAGMSITESYAML 1194 Query: 1189 PGAAVSGWYFSHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 P AAVSGWYF+HP+++YF VG++ +DQVADYA+RKG EAERWL PNLGY PED Sbjct: 1195 PTAAVSGWYFAHPEARYFNVGKINRDQVADYARRKGMKPAEAERWLAPNLGYEPED 1250 >tr|B7VI88|B7VI88_VIBSL Tax_Id=575788 SubName: Full=Methionine synthase;[Vibrio splendidus] Length = 1225 Score = 1548 bits (4007), Expect = 0.0 Identities = 774/1228 (63%), Positives = 952/1228 (77%), Gaps = 17/1228 (1%) Query: 16 LTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIEGI 75 + A L QRI++IDG MGT IQ + +E YRGERF DW SDL GNNDLL LTQP++I+ I Sbjct: 9 IDALLKQRILLIDGGMGTTIQDYKLEEQDYRGERFADWHSDLKGNNDLLVLTQPKLIKDI 68 Query: 76 HREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEKPR 133 H EYL+AGADILETNTFNA ++++DYDM L+ E+NY DE++ TP+KPR Sbjct: 69 HMEYLEAGADILETNTFNATTIAMADYDMESLSEEINYAAAKLAREAADEWTVKTPDKPR 128 Query: 134 YVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFDSL 193 +VAG LGPT RT S+SPDVNDPG RNVS+D+LV AY E+ L+ GG+D+I+IETIFD+L Sbjct: 129 FVAGVLGPTNRTCSLSPDVNDPGYRNVSFDELVEAYSESTRALIKGGSDLILIETIFDTL 188 Query: 194 NAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNC 253 NAKA FAVE++FE+ G PV+ISGTITDASGRTLSGQ TEAF+NA+RH KPI+ GLNC Sbjct: 189 NAKACAFAVESVFEEVGIILPVMISGTITDASGRTLSGQTTEAFYNALRHVKPISFGLNC 248 Query: 254 ALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVNLV 313 ALG E+R Y+ EM+RI++ VS +PNAGLPNAFGEYD +PE A ++ E+A++G +NL+ Sbjct: 249 ALGPDELREYVGEMSRISECHVSAHPNAGLPNAFGEYDLSPEDMAEHVKEWAESGFLNLI 308 Query: 314 GGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNITG 373 GGCCGT P HI ++A+ VEG PR+LP++PV+ RLSGLEPL IS +SLFVN+GERTN+TG Sbjct: 309 GGCCGTTPEHIRQMAEAVEGVTPRQLPDLPVSCRLSGLEPLTISKESLFVNVGERTNVTG 368 Query: 374 SARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDIS 433 SARF+ LIK E YD ALSVA +QVE GAQ+IDINMDEGM+D A M +F L A+EP+IS Sbjct: 369 SARFKRLIKEELYDEALSVAREQVENGAQIIDINMDEGMLDAEACMVKFLNLCASEPEIS 428 Query: 434 RVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAFDE 493 +VPVM+DSSKWEVIEAGLK +QGK IVNSIS+KEG+EKFV +A+L R+YGAAV+VMAFDE Sbjct: 429 KVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVEQAKLVRRYGAAVIVMAFDE 488 Query: 494 KGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACA 553 GQAD ER+ EIC AY IL +EVGFP EDIIFDPN FA+ATGI+EH Y +DFIEA Sbjct: 489 VGQADTRERKVEICTNAYNILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYAVDFIEAVG 548 Query: 554 WIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPYDS 613 IK +LP ISGG+SNVSFSFRGNN VREAIHAVFL+H K G+DMGIVNAG L YD+ Sbjct: 549 DIKRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVNAGQLEIYDN 608 Query: 614 IDPELRERIEDVVLNRREDAAERLLEIAERF--NTKGKSEDPAAAEWRSLPVRERITHAL 671 + +LRE +EDVVLNRR+D+ ERLL+IA + GK ED +A EWR+ PV +R+ H+L Sbjct: 609 VPEDLREAVEDVVLNRRDDSTERLLDIATEYLERAVGKVEDKSALEWRTWPVEKRLEHSL 668 Query: 672 VKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSAR 731 VKGI + DTEE R RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVKSAR Sbjct: 669 VKGITDFIVEDTEEARVN----ASRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSAR 724 Query: 732 VMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTV 791 VMK+AVA+L PFI A K + TNG I++ATVKGDVHDIGKNIVGVVLQCNNY + Sbjct: 725 VMKQAVAHLEPFINATK------DVGATNGKILLATVKGDVHDIGKNIVGVVLQCNNYEI 778 Query: 792 VDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGATT 851 +DLGVMV EKIL A+E + DIIGLSGLITPSLDEMV+ A MER+G ++PLLIGGATT Sbjct: 779 IDLGVMVSCEKILKVAKEENVDIIGLSGLITPSLDEMVHVAKEMERQGFKLPLLIGGATT 838 Query: 852 SRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERHSQK 911 S+AHTAVK+ S PVV+V +ASR+V V +LL ++ +P +E DY +R++H++K Sbjct: 839 SKAHTAVKIEQNYSEPVVYVNNASRAVGVCTSLLSNELKPAFVEKLDIDYDRVRDQHNRK 898 Query: 912 NERPM-LTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFNAWE 970 R +TLE+ARAN+ IDWD YTPP PA+ GV F+D+D+A LR+YIDW PFF W Sbjct: 899 KPRTKPVTLERARANKVAIDWDAYTPPAPAKP-GVHIFNDFDVATLRQYIDWTPFFMTWS 957 Query: 971 MKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIEVYT 1030 + G++P ILN+ GE A++L+ DA ++LD + +EK L A G+ FPAN+VGDDIEVYT Sbjct: 958 LVGKYPAILNHEEVGEEAKRLFKDANDLLDRVQKEKLLEARGMCAMFPANSVGDDIEVYT 1017 Query: 1031 DETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTKIV 1090 DE+R EVL LHNLRQQ E G N L D+IAPKD+G AD++G FAVT G+G + Sbjct: 1018 DESRTEVLKVLHNLRQQTEKPKGF-NYCLSDYIAPKDSGKADWIGGFAVTGGIGERELAD 1076 Query: 1091 EFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYVGIR 1150 E+K DDY+AI+++++ADRLAEAFAE +H+ VR++ WGY PDE+L N+ LI E+Y GIR Sbjct: 1077 EYKANGDDYNAIMIQAVADRLAEAFAEYLHKEVRKDIWGYSPDEELSNDDLIREKYQGIR 1136 Query: 1151 PAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGR 1210 PAPGYPACPEHTEK TL+ELMDV K + LT S AMWPGA+VSG YFSHP ++YF + + Sbjct: 1137 PAPGYPACPEHTEKGTLWELMDVEKAIDMSLTTSYAMWPGASVSGMYFSHPDARYFAIAQ 1196 Query: 1211 MAQDQVADYAKRKGWTLPEAERWLGPNL 1238 + QDQV YA RKGW + EAERWLGPN+ Sbjct: 1197 IQQDQVDSYADRKGWNMLEAERWLGPNI 1224 >tr|Q3SM63|Q3SM63_THIDA Tax_Id=292415 SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase;[Thiobacillus denitrificans] Length = 1237 Score = 1547 bits (4005), Expect = 0.0 Identities = 790/1236 (63%), Positives = 936/1236 (75%), Gaps = 17/1236 (1%) Query: 13 TDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQII 72 TD L + L QRI+V+DGAMGT IQ + EA YRGERF D+ DL GNNDLL LTQP II Sbjct: 14 TDLLHSLLAQRILVLDGAMGTMIQSYKLGEADYRGERFADFAHDLKGNNDLLCLTQPAII 73 Query: 73 EGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFST--PE 130 + IH +YL AGADILETN+FNA A+S++DY M L ELN+ DE + P Sbjct: 74 KEIHAKYLAAGADILETNSFNATAISMADYRMEHLVPELNFAAAKLAREAADEATAQNPA 133 Query: 131 KPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIF 190 KPR+VAG LGPT+RTA+ISPDVNDPG RNV++DQL AYLEA +GLV GGADI+++ETIF Sbjct: 134 KPRFVAGVLGPTSRTATISPDVNDPGFRNVTFDQLREAYLEAIDGLVKGGADILMVETIF 193 Query: 191 DSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVG 250 D+LNAKAA+FA+E FE R PV+ISGTITDASGRTLSGQ EAFWN++RHA+P+++G Sbjct: 194 DTLNAKAALFAIEEYFEINNMRLPVMISGTITDASGRTLSGQTGEAFWNSVRHARPLSIG 253 Query: 251 LNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLV 310 LNCALG +R Y+ E++ A+ F+S +PNAGLPNAFGEYD A +I E+A AGL+ Sbjct: 254 LNCALGPDLLRQYVEELSNKAEVFISAHPNAGLPNAFGEYDMDGAEMAKHIGEWARAGLL 313 Query: 311 NLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTN 370 N+VGGCCGT+P HIA IAK VEG APR P + A RLSGLEP N+ DSLFVN+GERTN Sbjct: 314 NIVGGCCGTSPSHIAAIAKAVEGVAPRVPPVLEPAMRLSGLEPFNVGKDSLFVNVGERTN 373 Query: 371 ITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEP 430 +TGS F +I YD ALSVA QQVE GAQVIDINMDEGM+D AAM RF LIA+EP Sbjct: 374 VTGSKAFARMILEGRYDDALSVARQQVENGAQVIDINMDEGMLDAEAAMVRFLHLIASEP 433 Query: 431 DISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMA 490 DI+RVP+MIDSSKW VIEAGLK +QGK IVNSISMKEGE +F+ A+LC +YGAAV+VMA Sbjct: 434 DIARVPIMIDSSKWNVIEAGLKCIQGKGIVNSISMKEGEAEFIERAKLCLRYGAAVIVMA 493 Query: 491 FDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIE 550 FDE GQAD R+ EIC RAY++LTE VGFPAEDIIFDPN FA+ATGIEEHA Y +DFIE Sbjct: 494 FDETGQADTYARKTEICTRAYKLLTETVGFPAEDIIFDPNIFAVATGIEEHANYAVDFIE 553 Query: 551 ACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVP 610 A WI++NLP H+SGG+SNVSFSFRGN+ VREAIH FL+HAI+AG+DMGIVNAG L Sbjct: 554 ATRWIRQNLPYAHVSGGVSNVSFSFRGNDAVREAIHTAFLYHAIQAGMDMGIVNAGQLGV 613 Query: 611 YDSIDPELRERIEDVVLNRREDAAERLLEIAE--RFNTKGKSEDPAAAEWRSLPVRERIT 668 Y+++DPEL+ER+EDV+LNRR DA ERL+ AE + K K ED A WRSLPV ER+T Sbjct: 614 YENLDPELKERVEDVLLNRRADATERLVAFAEGVKGGAKEKVEDLA---WRSLPVNERLT 670 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 HALV+GI ++ DTE R E RP+ VIEGPLM GMNVVGDLFGAGKMFLPQVVK Sbjct: 671 HALVQGITQYIVEDTEAARLE----AERPLHVIEGPLMAGMNVVGDLFGAGKMFLPQVVK 726 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVA+L+P+IEA+K S ++ G I+MATVKGDVHDIGKNIVGVVL CN Sbjct: 727 SARVMKQAVAHLIPYIEADKRAGDS----QSAGKIVMATVKGDVHDIGKNIVGVVLGCNG 782 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPA+KIL AARE+ ADIIGLSGLITPSL+EM + A M+R+G IPLLIGG Sbjct: 783 YEIVDLGVMVPAQKILDAAREHKADIIGLSGLITPSLEEMAHVAKEMQRQGFTIPLLIGG 842 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS AHTAVK+ P PVV+VKDASR+V V LL + R ADYA R RH Sbjct: 843 ATTSLAHTAVKIEPNYEHPVVYVKDASRAVGVCTQLLSGELRDAFAAEVRADYAQTRARH 902 Query: 909 -SQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 K++ LTL ARAN+ IDW YTPP+P Q GV YDLA+L E IDW PFF Sbjct: 903 LKHKSDTARLTLADARANKFGIDWASYTPPVPNQP-GVHVLKAYDLAKLVETIDWTPFFA 961 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 +WE+ G++P IL++ G A KL++DAQ ML+ ++ E W+ A V G FPANAV DDIE Sbjct: 962 SWELHGKYPKILDDEVVGAEATKLFSDAQAMLNRMVAENWVEARAVFGLFPANAVDDDIE 1021 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 VY DE+R++ LTT HNLRQQ + G N L DF+APK +GL DY+GAF VTAG+G Sbjct: 1022 VYADESRSQALTTWHNLRQQAKKPEGRANLCLADFVAPKASGLKDYLGAFVVTAGIGEDE 1081 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 + F+ A DDYSAIL +S+ DRLAEAFAE +H RVR EFWGY DE L N+ LI E+Y Sbjct: 1082 RAKAFEAAHDDYSAILFKSLCDRLAEAFAEHLHLRVRREFWGYAADEALPNDDLIAEKYR 1141 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEH+EK LF L+D T G+ELTE+ AMWPGAAVSG+Y SHP SQYF Sbjct: 1142 GIRPAPGYPACPEHSEKAALFGLLDATNAIGVELTENFAMWPGAAVSGFYLSHPDSQYFA 1201 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKGW + AERWLGPNLGY PE Sbjct: 1202 VAKIERDQVEDYARRKGWDVKTAERWLGPNLGYQPE 1237 >sp|Q7MHB1|METH_VIBVY Tax_Id=196600 (metH)RecName: Full=Methionine synthase; EC=2.1.1.13; AltName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase; AltName: Full=Methionine synthase, vitamin-B12 dependent; Short=MS;[Vibrio vulnificus] Length = 1226 Score = 1546 bits (4003), Expect = 0.0 Identities = 777/1228 (63%), Positives = 945/1228 (76%), Gaps = 17/1228 (1%) Query: 16 LTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIEGI 75 + A L QRI++IDG MGT IQ + E YRGERF DW SDL GNNDLL LTQPQ+I+ I Sbjct: 9 IEAQLKQRILLIDGGMGTMIQGYKLQEQDYRGERFADWHSDLKGNNDLLVLTQPQLIKEI 68 Query: 76 HREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFST--PEKPR 133 H YL+AGADILETNTFNA ++++DYDM L+ E+N+ DE++ P KPR Sbjct: 69 HHAYLEAGADILETNTFNATTIAMADYDMESLSEEINFAAAKLAREAADEWTAKNPAKPR 128 Query: 134 YVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFDSL 193 YVAG LGPT RT SISPDVNDPG RNVS+D+LV AY E+ L+ GG+D+I+IETIFD+L Sbjct: 129 YVAGVLGPTNRTCSISPDVNDPGYRNVSFDELVEAYSESTRALIRGGSDLILIETIFDTL 188 Query: 194 NAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNC 253 NAKA FAVE++FE+ G PV+ISGTITDASGRTLSGQ TEAF+N++RH +PI+ GLNC Sbjct: 189 NAKACAFAVESVFEELGFALPVMISGTITDASGRTLSGQTTEAFYNSLRHVRPISFGLNC 248 Query: 254 ALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVNLV 313 ALG E+RPY+ E++RI++TFVS +PNAGLPNAFGEYD +PE A ++ E+A +G +NL+ Sbjct: 249 ALGPDELRPYVEELSRISETFVSTHPNAGLPNAFGEYDLSPEEMAEHVKEWAQSGFLNLI 308 Query: 314 GGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNITG 373 GGCCGT P HI +A VEG++PR LPEIPVA RLSGLEPL I+ D+LFVN+GERTN+TG Sbjct: 309 GGCCGTTPEHIRHMAMAVEGESPRVLPEIPVACRLSGLEPLTIAKDTLFVNVGERTNVTG 368 Query: 374 SARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDIS 433 SARF+ LIK E YD AL VA +QVE GAQ+IDINMDEGM+D A M RF L A+EP+IS Sbjct: 369 SARFKRLIKEELYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEIS 428 Query: 434 RVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAFDE 493 +VP+M+DSSKWEVIEAGLK +QGK IVNSIS+KEG+EKFV +A+L R+YGAAV+VMAFDE Sbjct: 429 KVPIMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVEQAKLIRRYGAAVIVMAFDE 488 Query: 494 KGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACA 553 GQAD ER+ EIC +AYRIL +EVGFP ED+IFDPN FA+ATGI+EH Y +DFIEA A Sbjct: 489 VGQADTRERKLEICTKAYRILVDEVGFPPEDVIFDPNIFAVATGIDEHNNYAVDFIEAVA 548 Query: 554 WIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPYDS 613 IK +LP ISGG+SNVSFSFRGNN VREAIHAVFL+H K G+DMGIVNAG L YD+ Sbjct: 549 DIKRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVNAGQLEIYDN 608 Query: 614 IDPELRERIEDVVLNRREDAAERLLEIAERF--NTKGKSEDPAAAEWRSLPVRERITHAL 671 + +LRE +EDVVLNRR+DA ERLLEIAE + N GK ED +A EWR+ V +R+ HAL Sbjct: 609 VPEKLREAVEDVVLNRRDDATERLLEIAEEYRENAVGKQEDASALEWRTWSVEKRLEHAL 668 Query: 672 VKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSAR 731 VKGI + DTEE R +P+EVIEGPLMDGMNVVGDLFG GKMFLPQVVKSAR Sbjct: 669 VKGITEFIVEDTEEARLN----ASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSAR 724 Query: 732 VMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTV 791 VMK+AVA+L PFI A K Q GS +NG I++ATVKGDVHDIGKNIVGVVLQCNNY + Sbjct: 725 VMKQAVAHLEPFINASK-QVGS-----SNGKILLATVKGDVHDIGKNIVGVVLQCNNYEI 778 Query: 792 VDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGATT 851 +DLGVMVP E+IL A+E DIIGLSGLITPSLDEMV+ A MER G +PLLIGGATT Sbjct: 779 IDLGVMVPCEQILKVAKEQQVDIIGLSGLITPSLDEMVHVAKEMERLGFDLPLLIGGATT 838 Query: 852 SRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERHSQK 911 S+AHTAVK+ S PVV+V +ASR+V V +LL D+ RP +E ADY +R++H++K Sbjct: 839 SKAHTAVKIEQNYSHPVVYVNNASRAVGVCTSLLSDELRPAFVERLQADYELVRDQHNRK 898 Query: 912 NERPM-LTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFNAWE 970 R +TLE ARAN+ IDW YTPP P+Q GV F D+D+A LR+YIDW PFF W Sbjct: 899 KPRTKPVTLEAARANKVAIDWQSYTPPAPSQP-GVHVFDDFDVATLRQYIDWTPFFLTWS 957 Query: 971 MKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIEVYT 1030 + G++P I + GE A++L+ DA E LD + +E L A G+ G FPA +VGDDIEVYT Sbjct: 958 LVGKYPTIFEHEEVGEEAKRLFEDANEWLDRIEQEGLLKARGMCGLFPAASVGDDIEVYT 1017 Query: 1031 DETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTKIV 1090 DE+R +V LHNLRQQ E G N L D++APK++G D++GAFAVT G+ + Sbjct: 1018 DESRTQVAKVLHNLRQQTEKPKG-ANYCLSDYVAPKESGKKDWIGAFAVTGGVNERELAD 1076 Query: 1091 EFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYVGIR 1150 +FK DDY+AI+++++ADRLAEAFAE +H+RVR+E WGY DE L NE LI E+Y GIR Sbjct: 1077 QFKAQGDDYNAIMIQAVADRLAEAFAEYLHERVRKEIWGYAADENLSNEELIREKYQGIR 1136 Query: 1151 PAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGR 1210 PAPGYPACPEHTEK L+EL++V + G+ LT S AMWPGA+VSGWYFSHP S+YF + + Sbjct: 1137 PAPGYPACPEHTEKGPLWELLNVEETIGMSLTSSYAMWPGASVSGWYFSHPDSRYFAIAQ 1196 Query: 1211 MAQDQVADYAKRKGWTLPEAERWLGPNL 1238 + QDQV YAKRKGW L EAE+WLGPN+ Sbjct: 1197 IQQDQVESYAKRKGWDLLEAEKWLGPNI 1224 >tr|Q0A6R3|Q0A6R3_ALHEH Tax_Id=187272 SubName: Full=Methionine synthase (B12-dependent); EC=2.1.1.13;[Alkalilimnicola ehrlichei] Length = 1245 Score = 1545 bits (4000), Expect = 0.0 Identities = 778/1238 (62%), Positives = 935/1238 (75%), Gaps = 13/1238 (1%) Query: 11 DCTDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQ 70 DC L AL +RI+++D MGT IQ + +EA +RGERF D P DL GNNDLL LT+P+ Sbjct: 17 DCRKTLEDALARRILILDSGMGTMIQNRKLEEADFRGERFADHPCDLKGNNDLLVLTRPE 76 Query: 71 IIEGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXD--EFST 128 +I IH E L GADI+ETNTF++ ++ +DY M LAYE+N D E Sbjct: 77 VIREIHAENLAVGADIVETNTFSSTTIAQADYRMEHLAYEMNVAAARLAREACDAAEREN 136 Query: 129 PEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIET 188 P+ PRYVAGALGPT RTASISPDVN+PG RN+++DQL AAYLEAA GLV+GGAD+++IET Sbjct: 137 PDHPRYVAGALGPTNRTASISPDVNNPGYRNITFDQLRAAYLEAARGLVEGGADLLLIET 196 Query: 189 IFDSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIA 248 IFD+LNAKAA++A+E LFE+ GRR PV+ISGTITDASGRTLSGQ TEAFWN++RHA P Sbjct: 197 IFDTLNAKAAIYALEELFEEIGRRLPVMISGTITDASGRTLSGQTTEAFWNSVRHANPFT 256 Query: 249 VGLNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAG 308 VGLNCALGA +MRP++ E++R+ADT+V+ YPNAGLPN FGEYD+TPE A + EFA++G Sbjct: 257 VGLNCALGADQMRPFVKEISRVADTYVTIYPNAGLPNEFGEYDQTPEEMAAIVREFAESG 316 Query: 309 LVNLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGER 368 VN+VGGCCGT P HIA + + V PR +PE A RLSGLEP N+ DSLFVN+GER Sbjct: 317 FVNVVGGCCGTTPEHIAALREAVADCVPRPIPERERAMRLSGLEPFNVGKDSLFVNVGER 376 Query: 369 TNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAA 428 TN+TGSARFR LIK EDYDTAL VA +QVE GAQ+IDINMDEGM+D A M F LIAA Sbjct: 377 TNVTGSARFRRLIKEEDYDTALEVAREQVENGAQIIDINMDEGMLDARACMVDFLNLIAA 436 Query: 429 EPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVV 488 EPDI+RVPVMID+SKWEV+EAGL+ +QGK +VNSIS+KEGE F+ +A ++YGAAVVV Sbjct: 437 EPDIARVPVMIDASKWEVLEAGLQCLQGKAVVNSISLKEGEAPFLEQAEKLKRYGAAVVV 496 Query: 489 MAFDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDF 548 MAFDE GQAD RR EIC RAYR+L + GFP EDIIFDPN F +ATGI EH YGIDF Sbjct: 497 MAFDEDGQADTYARRIEICERAYRLLVDRAGFPPEDIIFDPNVFPVATGIPEHDNYGIDF 556 Query: 549 IEACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGAL 608 IEA WIK NLP +SGG+SN+SFSFRGNN VREA+H+ FL+HAIKAGLDM IVNAG + Sbjct: 557 IEATRWIKANLPYAKVSGGLSNLSFSFRGNNAVREAMHSAFLYHAIKAGLDMAIVNAGQI 616 Query: 609 VPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPAA-AEWRSLPVRERI 667 YD I +L ER+EDV+LNRREDA ERLL AE +G ++ A WR LPV +R+ Sbjct: 617 EVYDDIPKDLLERVEDVILNRREDATERLLAFAESVKDQGGAKKKEADLAWRELPVNKRL 676 Query: 668 THALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVV 727 HALVKGI ++D D EE R A RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVV Sbjct: 677 EHALVKGIVDYIDDDVEEAR----QAHDRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVV 732 Query: 728 KSARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCN 787 KSARVMKKAVAYLLP+IEAEKA+ DK I+MATVKGDVHDIGKNIVGVVLQCN Sbjct: 733 KSARVMKKAVAYLLPYIEAEKAEG----DDKPAAHILMATVKGDVHDIGKNIVGVVLQCN 788 Query: 788 NYTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIG 847 N+ V D+GVM PAE IL A + DIIGLSGLITPSL+EM N A M+R G+ PLLIG Sbjct: 789 NFKVTDIGVMQPAEAILETAEKEKVDIIGLSGLITPSLEEMANVAKEMQRRGLTQPLLIG 848 Query: 848 GATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRER 907 GATTSR HTAVK+AP+ V++VKDASR+V VA+ L+ + +R + +Y +R + Sbjct: 849 GATTSRVHTAVKIAPQYDQEVIYVKDASRAVGVASNLMSETRREAYVAGLREEYERVRRQ 908 Query: 908 HSQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFF 966 H+ + ++ + +E ARANRTPIDWD + P P GV DY LAEL +YIDW PFF Sbjct: 909 HANRQKKQKWVKIETARANRTPIDWDAFEPAFP-NAPGVHVLDDYPLAELVDYIDWTPFF 967 Query: 967 NAWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDI 1026 +WE+ G +P IL++ GE AR L++DA+ ML +I E+WLTA V G FPAN VGDD Sbjct: 968 KSWELAGSYPKILDDEVVGEQARTLFHDAKAMLAQIIEERWLTARAVFGLFPANGVGDDT 1027 Query: 1027 EVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQ 1086 E+Y DE RA+VL TLH+LRQQ E G P++SL DFIAPK+TG D++GAFAVT G+G Sbjct: 1028 ELYADEDRAQVLLTLHHLRQQTEKPEGRPHQSLADFIAPKETGKPDHIGAFAVTTGIGID 1087 Query: 1087 TKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERY 1146 I F+ DDY AILL+++ADRLAEAFAER+H+RVR+EFWGY PDEQLDN LI E Y Sbjct: 1088 EHIARFEADHDDYHAILLKALADRLAEAFAERLHERVRKEFWGYAPDEQLDNRGLIKEHY 1147 Query: 1147 VGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYF 1206 GIRPA GYPACP+HTEK ++ L+DV +R G+ LTES AM P AAVSG YF+HP+S+YF Sbjct: 1148 QGIRPAAGYPACPDHTEKDLIWALLDVDQRIGLTLTESKAMVPTAAVSGLYFAHPKSRYF 1207 Query: 1207 VVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 +G++ QDQV DYA+RKG + ERWL PNLGY PED Sbjct: 1208 GIGKIYQDQVEDYARRKGMSRRAMERWLAPNLGYEPED 1245 >tr|A6D961|A6D961_9VIBR Tax_Id=391591 (metH)SubName: Full=B12-dependent methionine synthase; EC=2.1.1.13;[Vibrio shilonii AK1] Length = 1225 Score = 1545 bits (3999), Expect = 0.0 Identities = 772/1228 (62%), Positives = 947/1228 (77%), Gaps = 17/1228 (1%) Query: 16 LTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIEGI 75 + + L QRI++IDG MGT IQ + +E YRGERF DWPSDL GNNDLL LTQP +I+ I Sbjct: 9 IESQLRQRILLIDGGMGTMIQGYKLEEEDYRGERFADWPSDLKGNNDLLVLTQPALIKEI 68 Query: 76 HREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFST--PEKPR 133 H YL+AGADILETNTFNA ++++DYDM L+ E+NY DE++T P++PR Sbjct: 69 HSAYLEAGADILETNTFNATTIAMADYDMESLSEEINYQAAKLAREAADEWTTKTPDRPR 128 Query: 134 YVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFDSL 193 YVAG LGPT RT SISPDVNDPG RNV++D+LV AY E+ + L+ GG+D+I+IETIFD+L Sbjct: 129 YVAGVLGPTNRTCSISPDVNDPGYRNVTFDELVEAYSESTHALIKGGSDLILIETIFDTL 188 Query: 194 NAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNC 253 NAKA FAVE++FE+ G PV+ISGTITDASGRTLSGQ TEAF+NA+RH +P++ GLNC Sbjct: 189 NAKACAFAVESVFEELGYELPVMISGTITDASGRTLSGQTTEAFYNALRHVRPLSFGLNC 248 Query: 254 ALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVNLV 313 ALG E+R Y+ EM+RI ++FVS +PNAGLPNAFGEYD +PE A +I E+A +G +NLV Sbjct: 249 ALGPDELRQYVEEMSRIGESFVSAHPNAGLPNAFGEYDLSPEDMAEHIGEWARSGFLNLV 308 Query: 314 GGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNITG 373 GGCCGT P HI ++A VEG PR LPE+PVA RLSGLEPL I DSLF+N+GERTN+TG Sbjct: 309 GGCCGTTPEHIRQMANAVEGVTPRPLPELPVACRLSGLEPLTIEKDSLFINVGERTNVTG 368 Query: 374 SARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDIS 433 SARF+ LIK E YD AL VA QQVE GAQ+IDINMDEGM+D A M RF L A+EP+IS Sbjct: 369 SARFKRLIKEEQYDEALEVARQQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEIS 428 Query: 434 RVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAFDE 493 +VP+M+DSSKWEVIEAGLK +QGK IVNSISMKEG+EKFV +A+L R+YGAAV+VMAFDE Sbjct: 429 KVPIMVDSSKWEVIEAGLKCIQGKGIVNSISMKEGKEKFVEQAKLIRRYGAAVIVMAFDE 488 Query: 494 KGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACA 553 GQA+ ER+ EIC AY IL +EVGFP EDIIFDPN FA+ATGIEEH Y +DFIEA A Sbjct: 489 IGQAETRERKLEICTNAYNILVDEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEAVA 548 Query: 554 WIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPYDS 613 IK +LP ISGG+SNVSFSFRGNN VREAIHAVFL+H K G+DMGIVNAG L YD+ Sbjct: 549 DIKRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVNAGQLEIYDN 608 Query: 614 IDPELRERIEDVVLNRREDAAERLLEIAERFNTK--GKSEDPAAAEWRSLPVRERITHAL 671 + +LRE +EDVVLNRR+D ERLL+IA + K GK ED +A EWR+ PV +R+ HAL Sbjct: 609 VPEKLREAVEDVVLNRRDDGTERLLDIAAEYANKGVGKEEDASALEWRTWPVSKRLEHAL 668 Query: 672 VKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSAR 731 VKGI + DTEE R +P+EVIEGPLMDGMNVVGDLFG GKMFLPQVVKSAR Sbjct: 669 VKGITEFIVEDTEEARVN----ASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSAR 724 Query: 732 VMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTV 791 VMK+AVA+L PFI AEK Q+GS +NG I++ATVKGDVHDIGKNIVGVVLQCNNY + Sbjct: 725 VMKQAVAHLEPFINAEK-QAGS-----SNGKILLATVKGDVHDIGKNIVGVVLQCNNYEI 778 Query: 792 VDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGATT 851 +DLGVMVP E IL A+E + DIIGLSGLITPSLDEMV+ A MER+G +PLLIGGATT Sbjct: 779 IDLGVMVPCETILKVAKEENVDIIGLSGLITPSLDEMVHVAKEMERQGFTLPLLIGGATT 838 Query: 852 SRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERHSQK 911 S+AHTAVK+ S PVV+V +ASR+V V +LL ++ +P +E DY +R++H++K Sbjct: 839 SKAHTAVKIEQNYSEPVVYVNNASRAVGVCTSLLSEELKPAFIEKLDIDYERVRDQHNRK 898 Query: 912 NERPM-LTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFNAWE 970 R +TLE+ARAN+ IDW YTPP+PA+ GV F ++++A LR YIDW PFF W Sbjct: 899 KPRTKPVTLEEARANKVAIDWQNYTPPIPAKS-GVHVFENFEVATLRNYIDWTPFFMTWS 957 Query: 971 MKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIEVYT 1030 + G++P IL + GE A++L++DA E+LD + RE L A+G+ FPA +VGDDIEVYT Sbjct: 958 LVGKYPAILEHEEVGEEAKRLFHDANELLDRVEREGLLKASGMCALFPAASVGDDIEVYT 1017 Query: 1031 DETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTKIV 1090 DETR +V LHNLRQQ E G N L D++APK++G D++GAFAVT G+G + Sbjct: 1018 DETRTQVRKVLHNLRQQTEKPKGF-NYCLSDYVAPKESGKQDWIGAFAVTGGIGERELAD 1076 Query: 1091 EFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYVGIR 1150 E+K DDY+AI+++++ADRLAEAFAE MH++VR+E WGY DE L N+ LI E+Y GIR Sbjct: 1077 EYKAQGDDYNAIMIQAVADRLAEAFAEYMHEKVRKEIWGYSADEALSNDDLIREKYQGIR 1136 Query: 1151 PAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGR 1210 PAPGYPACPEHTEK L+EL++V + G+ LT S AMWPGA+VSGWYFSHP S+YF + + Sbjct: 1137 PAPGYPACPEHTEKGALWELLEVEQTIGMSLTSSYAMWPGASVSGWYFSHPDSRYFAIAQ 1196 Query: 1211 MAQDQVADYAKRKGWTLPEAERWLGPNL 1238 + QDQV YA RKGW EAE+WLGPN+ Sbjct: 1197 IQQDQVDSYADRKGWDQTEAEKWLGPNI 1224 >tr|B7UPG9|B7UPG9_ECO27 Tax_Id=574521 (metH)SubName: Full=Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent;[Escherichia coli O127:H6] Length = 1227 Score = 1544 bits (3997), Expect = 0.0 Identities = 781/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLCAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIS 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWVVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227 >tr|Q2BMJ6|Q2BMJ6_9GAMM Tax_Id=207954 SubName: Full=Cobalamin-dependent methionine synthase;[Neptuniibacter caesariensis] Length = 1234 Score = 1544 bits (3997), Expect = 0.0 Identities = 772/1238 (62%), Positives = 963/1238 (77%), Gaps = 17/1238 (1%) Query: 13 TDALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQII 72 TD L+ +L QRIM++DG MGT IQ + +EA YRGERF DW ++ GNNDLL LT+P+II Sbjct: 7 TDILSESLKQRIMILDGGMGTMIQDYKLEEADYRGERFADWHIEVKGNNDLLVLTKPEII 66 Query: 73 EGIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPE 130 + IH+EYL+AGADI+ETNTFNA ++++DY+M L+ E+N DE + TP+ Sbjct: 67 KAIHKEYLEAGADIIETNTFNATQIAMADYEMESLSREINVEAARLAREACDEITAQTPD 126 Query: 131 KPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIF 190 +PRYVAG LGPT RT SISPDVNDP RNVS++ LV AY E+ +GLV+GG+DII+IETIF Sbjct: 127 RPRYVAGVLGPTNRTCSISPDVNDPSFRNVSFNDLVEAYTESIDGLVEGGSDIILIETIF 186 Query: 191 DSLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVG 250 D+LNAKAA++AVET F+D R PV+ISGTITDASGRTLSGQ TEAFWN++RHAKPI+VG Sbjct: 187 DTLNAKAAIYAVETYFDDNDIRLPVMISGTITDASGRTLSGQTTEAFWNSVRHAKPISVG 246 Query: 251 LNCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLV 310 LNCALG E+R Y+ E++RI++TFVS +PNAGLPNAFG YDETPE A I+E+A +G + Sbjct: 247 LNCALGPKELRQYVEELSRISETFVSTHPNAGLPNAFGGYDETPEQMATEISEWAQSGFL 306 Query: 311 NLVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTN 370 N++GGCCGT P HI + + VE +APR LP++PV +RLSGLEP+NI +D+LFVN+GERTN Sbjct: 307 NIIGGCCGTTPAHIKAMREAVENEAPRALPQLPVESRLSGLEPMNIGEDTLFVNVGERTN 366 Query: 371 ITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEP 430 +TGSA F+ LIK +DY+TAL VA QQVE GAQ+IDINMDEGM+D AAM +F LIA+EP Sbjct: 367 VTGSAMFKRLIKEQDYETALDVARQQVENGAQIIDINMDEGMLDAHAAMVKFLNLIASEP 426 Query: 431 DISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMA 490 DI+RVP+MIDSSKW+VIEAGL+ +QGK IVNSIS+KEGE+ F+ +A+ R+YGAAVVVMA Sbjct: 427 DIARVPIMIDSSKWDVIEAGLQCIQGKGIVNSISLKEGEDNFIEQAKKLRRYGAAVVVMA 486 Query: 491 FDEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIE 550 FDE GQAD ER+ EIC R+YR+L ++VG+P EDIIFDPN FA+ATGIEEH Y +DFI+ Sbjct: 487 FDETGQADTYERKIEICERSYRVLVDQVGYPPEDIIFDPNIFAVATGIEEHNNYAVDFIQ 546 Query: 551 ACAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVP 610 A WIK+NLP +SGG+SNVSFSFRGNNPVREAIH VFL+HAIK G+DMGIVNAG L Sbjct: 547 ATGWIKQNLPYAKVSGGVSNVSFSFRGNNPVREAIHCVFLYHAIKQGMDMGIVNAGQLAI 606 Query: 611 YDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA-AAEWRSLPVRERITH 669 YD + ELR +EDV+ N R+DA ERLL+IAE++ G ED EWRS V +R+ H Sbjct: 607 YDDLPEELRLAVEDVIQNSRDDATERLLDIAEKYRGDGSQEDDTKTQEWRSWDVNKRLEH 666 Query: 670 ALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKS 729 ALVKGI ++ DTEE R RP+ VIEGPLMDGM+VVGDLFGAGKMFLPQVVKS Sbjct: 667 ALVKGITEFIEDDTEEARQN----HERPLHVIEGPLMDGMSVVGDLFGAGKMFLPQVVKS 722 Query: 730 ARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNY 789 ARVMKKAVAYL+PFIE EK G+++ +NG I++ATVKGDVHDIGKNIVGVVLQCNNY Sbjct: 723 ARVMKKAVAYLMPFIEEEK--DGTSQ---SNGKIVLATVKGDVHDIGKNIVGVVLQCNNY 777 Query: 790 TVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGA 849 ++DLGVMVPAE IL ARE +AD+IGLSGLITPSLDEMV+ A MER+ IPLLIGGA Sbjct: 778 EIIDLGVMVPAETILRTAREENADLIGLSGLITPSLDEMVHMAKEMERQEFNIPLLIGGA 837 Query: 850 TTSRAHTAVKVAPR-RSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 TTS+AHTAVK+ P VV V +ASR+V VA++LL K + ++ +Y A+RERH Sbjct: 838 TTSKAHTAVKIDPAFNRDQVVHVTNASRAVNVASSLLGGK-KADYVKEIQEEYQAVRERH 896 Query: 909 SQK-NERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 + + N++ +TL+ AR N+ I+WD YTPP P Q G+ F D L +++EY DW PFF+ Sbjct: 897 AARMNDKRRVTLDAARENKFQIEWDEYTPPAPLQP-GIHVFDDISLNDIQEYFDWTPFFH 955 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVG-DDI 1026 +WE+ GR+P IL + GE A KL+NDAQ ML L+ +K LTA V+G FPAN +G DDI Sbjct: 956 SWELAGRYPRILTDEVIGEEATKLFNDAQAMLKDLVDQKLLTAKAVVGIFPANTIGHDDI 1015 Query: 1027 EVYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQ 1086 E+YTDE R++VL LH+LRQQ E AG N L DF+APK++G DY+GAFAVTAG G Sbjct: 1016 ELYTDENRSDVLMQLHHLRQQTEKVAGKANMCLADFVAPKESGKQDYLGAFAVTAGHGCD 1075 Query: 1087 TKIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERY 1146 + +++ DDY++I+++++ADR AEA AE MH +VR+E WGY EQL N+ LI E+Y Sbjct: 1076 ELVAKYEADHDDYNSIMVKALADRFAEALAEMMHDKVRKEIWGYGAAEQLSNDDLIAEKY 1135 Query: 1147 VGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYF 1206 GIRPAPGYPACPEHTEK L+EL+DV + TG+ LT++ AM P AAVSG+YFSHP+SQYF Sbjct: 1136 KGIRPAPGYPACPEHTEKGLLWELLDVEENTGMTLTDAYAMLPTAAVSGFYFSHPESQYF 1195 Query: 1207 VVGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPED 1244 V ++++DQV YAKRKG + EAERWL PNLGY PE+ Sbjct: 1196 GVAKISEDQVESYAKRKGMEMKEAERWLAPNLGYEPEE 1233 >tr|B7LKA7|B7LKA7_ESCF3 Tax_Id=585054 (metH)SubName: Full=Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; EC=2.1.1.13;[Escherichia fergusonii] Length = 1227 Score = 1543 bits (3995), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + GE A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGEEAKRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAE 1227 >sp|Q8DCJ7|METH_VIBVU Tax_Id=672 (metH)RecName: Full=Methionine synthase; EC=2.1.1.13; AltName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase; AltName: Full=Methionine synthase, vitamin-B12 dependent; Short=MS;[Vibrio vulnificus] Length = 1226 Score = 1543 bits (3994), Expect = 0.0 Identities = 775/1228 (63%), Positives = 944/1228 (76%), Gaps = 17/1228 (1%) Query: 16 LTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIEGI 75 + A L QRI++IDG MGT IQ + E YRGERF DW SDL GNNDLL LTQPQ+I+ I Sbjct: 9 IEAQLKQRILLIDGGMGTMIQGYKLQEQDYRGERFADWHSDLKGNNDLLVLTQPQLIKEI 68 Query: 76 HREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFST--PEKPR 133 H YL+AGADILETNTFNA ++++DYDM L+ E+N+ DE++ P KPR Sbjct: 69 HHAYLEAGADILETNTFNATTIAMADYDMESLSEEINFAAARLAREAADEWTAQNPAKPR 128 Query: 134 YVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFDSL 193 YVAG LGPT RT SISPDVNDPG RNVS+D+LV AY E+ L+ GG+D+I+IETIFD+L Sbjct: 129 YVAGVLGPTNRTCSISPDVNDPGYRNVSFDELVEAYSESTRALIRGGSDLILIETIFDTL 188 Query: 194 NAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNC 253 NAKA FAV+++FE+ G PV+ISGTITDASGRTLSGQ TEAF+N++RH +PI+ GLNC Sbjct: 189 NAKACAFAVDSVFEELGFALPVMISGTITDASGRTLSGQTTEAFYNSLRHVRPISFGLNC 248 Query: 254 ALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVNLV 313 ALG E+RPY+ E++RI++TFVS +PNAGLPNAFGEYD +PE A ++ E+A +G +NL+ Sbjct: 249 ALGPDELRPYVEELSRISETFVSTHPNAGLPNAFGEYDLSPEEMAEHVKEWAQSGFLNLI 308 Query: 314 GGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNITG 373 GGCCGT P HI +A VEG +PR LPEIPVA RLSGLEPL I+ D+LFVN+GERTN+TG Sbjct: 309 GGCCGTTPEHIRHMAMAVEGVSPRVLPEIPVACRLSGLEPLTIAKDTLFVNVGERTNVTG 368 Query: 374 SARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDIS 433 SARF+ LIK E YD AL VA +QVE GAQ+IDINMDEGM+D A M RF L A+EP+IS Sbjct: 369 SARFKRLIKEELYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEIS 428 Query: 434 RVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAFDE 493 +VP+M+DSSKWEVIEAGLK +QGK IVNSIS+KEG+EKFV +A+L R+YGAAV+VMAFDE Sbjct: 429 KVPIMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVEQAKLIRRYGAAVIVMAFDE 488 Query: 494 KGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACA 553 GQAD ER+ EIC +AYRIL +EVGFP ED+IFDPN FA+ATGI+EH Y +DFIEA A Sbjct: 489 VGQADTRERKLEICTKAYRILVDEVGFPPEDVIFDPNIFAVATGIDEHNNYAVDFIEAVA 548 Query: 554 WIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPYDS 613 IK +LP ISGG+SNVSFSFRGNN VREAIHAVFL+H K G+DMGIVNAG L YD+ Sbjct: 549 DIKRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVNAGQLEIYDN 608 Query: 614 IDPELRERIEDVVLNRREDAAERLLEIAERF--NTKGKSEDPAAAEWRSLPVRERITHAL 671 + +LRE +EDVVLNRR+DA ERLLEIAE + N GK ED +A EWR+ V +R+ HAL Sbjct: 609 VPEKLREAVEDVVLNRRDDATERLLEIAEEYRENAVGKQEDASALEWRTWSVEKRLEHAL 668 Query: 672 VKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSAR 731 VKGI + DTEE R +P+EVIEGPLMDGMNVVGDLFG GKMFLPQVVKSAR Sbjct: 669 VKGITEFIVEDTEEARLN----ASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSAR 724 Query: 732 VMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTV 791 VMK+AVA+L PFI A K Q+GS +NG I++ATVKGDVHDIGKNIVGVVLQCNNY + Sbjct: 725 VMKQAVAHLEPFINASK-QAGS-----SNGKILLATVKGDVHDIGKNIVGVVLQCNNYEI 778 Query: 792 VDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGATT 851 +DLGVMVP E+IL A+E DIIGLSGLITPSLDEMV+ A MER G +PLLIGGATT Sbjct: 779 IDLGVMVPCEQILKVAKEQQVDIIGLSGLITPSLDEMVHVAKEMERLGFDLPLLIGGATT 838 Query: 852 SRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERHSQK 911 S+AHTAVK+ S PVV+V +ASR+V V +LL D+ RP +E ADY +R++H++K Sbjct: 839 SKAHTAVKIEQNYSHPVVYVNNASRAVGVCTSLLSDELRPAFVERLQADYELVRDQHNRK 898 Query: 912 NERPM-LTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFNAWE 970 R +TLE ARAN+ IDW YTPP P+Q GV F D+D+A LR+YIDW PFF W Sbjct: 899 KPRTKPVTLEAARANKVAIDWQSYTPPAPSQP-GVHVFDDFDVATLRQYIDWTPFFLTWS 957 Query: 971 MKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIEVYT 1030 + G++P I + GE A++L+ DA E LD + +E L A G+ G FPA +VGDDIEVYT Sbjct: 958 LVGKYPTIFEHEEVGEEAKRLFGDANEWLDRIEQEGLLKARGMCGLFPAASVGDDIEVYT 1017 Query: 1031 DETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTKIV 1090 DE+R V LHNLRQQ E G N L D++APK++G D++GAFAVT G+ + Sbjct: 1018 DESRTHVAKVLHNLRQQTEKPKG-ANYCLSDYVAPKESGKKDWIGAFAVTGGVNERELAD 1076 Query: 1091 EFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYVGIR 1150 +FK DDY+AI+++++ADRLAEAFAE +H+RVR+E WGY DE L NE LI E+Y GIR Sbjct: 1077 QFKAQGDDYNAIMIQAVADRLAEAFAEYLHERVRKEIWGYAADENLSNEELIREKYQGIR 1136 Query: 1151 PAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGR 1210 PAPGYPACPEHTEK L+EL++V + G+ LT S AMWPGA+VSGWYFSHP S+YF + + Sbjct: 1137 PAPGYPACPEHTEKGPLWELLNVEETIGMSLTSSYAMWPGASVSGWYFSHPDSRYFAIAQ 1196 Query: 1211 MAQDQVADYAKRKGWTLPEAERWLGPNL 1238 + QDQV YA+RKGW L EAE+WLGPN+ Sbjct: 1197 IQQDQVESYAERKGWDLLEAEKWLGPNI 1224 >tr|Q8FB59|Q8FB59_ECOL6 Tax_Id=217992 (metH)SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase; EC=2.1.1.13;[Escherichia coli O6] Length = 1227 Score = 1542 bits (3993), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227 >tr|Q0TA51|Q0TA51_ECOL5 Tax_Id=362663 SubName: Full=5-methyltetrahydrofolate-homocysteine methyltransferase; EC=2.1.1.13;[Escherichia coli O6:K15:H31] Length = 1232 Score = 1542 bits (3993), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 11 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 70 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 71 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 130 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 131 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 190 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 191 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 250 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 251 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 310 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 311 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 370 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 371 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 430 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 431 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 490 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 491 DEQGQADTRARKIEICHRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 550 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 551 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 610 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 611 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 669 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 670 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 725 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 726 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 779 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 780 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 839 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 840 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 899 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 900 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 957 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 958 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1017 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1018 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDA 1076 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1077 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1136 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1137 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1196 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1197 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1232 >tr|B7N2L7|B7N2L7_ECO81 Tax_Id=585397 (metH)SubName: Full=Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; EC=2.1.1.13;[Escherichia coli O81] Length = 1227 Score = 1542 bits (3993), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227 >tr|C2DTM3|C2DTM3_ECOLX Tax_Id=525281 (metH)SubName: Full=B12-dependent methionine synthase; EC=2.1.1.13;[Escherichia coli 83972] Length = 1227 Score = 1542 bits (3993), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227 >tr|B3HRN6|B3HRN6_ECOLX Tax_Id=340197 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli F11] Length = 1227 Score = 1542 bits (3993), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICHRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227 >tr|Q1R3S9|Q1R3S9_ECOUT Tax_Id=364106 (metH)SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase; EC=2.1.1.13;[Escherichia coli] Length = 1227 Score = 1542 bits (3992), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227 >tr|C1HQ30|C1HQ30_9ESCH Tax_Id=469598 SubName: Full=B12-dependent methionine synthase;[Escherichia sp. 3_2_53FAA] Length = 1232 Score = 1542 bits (3992), Expect = 0.0 Identities = 780/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 11 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 70 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 71 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 130 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 131 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 190 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 191 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 250 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 251 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 310 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 311 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 370 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 371 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 430 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 431 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 490 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 491 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 550 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 551 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 610 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 611 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 669 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 670 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 725 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 726 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 779 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 780 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 839 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 840 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 899 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 900 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 957 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 958 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1017 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1018 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1076 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1077 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1136 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1137 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1196 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1197 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1232 >tr|A3Y1W0|A3Y1W0_9VIBR Tax_Id=314290 SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase;[Vibrio sp. MED222] Length = 1225 Score = 1542 bits (3992), Expect = 0.0 Identities = 772/1228 (62%), Positives = 951/1228 (77%), Gaps = 17/1228 (1%) Query: 16 LTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIEGI 75 + A L QRI++IDG MGT IQ + +E YRGERF DW SDL GNNDLL LTQP++I+ I Sbjct: 9 IDALLKQRILLIDGGMGTMIQDYKLEEQDYRGERFADWHSDLKGNNDLLVLTQPKLIKDI 68 Query: 76 HREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEKPR 133 H EYL+AGADILETNTFNA ++++DYDM L+ E+NY DE++ TP+KPR Sbjct: 69 HMEYLEAGADILETNTFNATTIAMADYDMESLSEEINYAAAKLAREAADEWTVKTPDKPR 128 Query: 134 YVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFDSL 193 +VAG LGPT RT S+SPDVNDPG RNVS+D+LV AY E+ L+ GG+D+I+IETIFD+L Sbjct: 129 FVAGVLGPTNRTCSLSPDVNDPGYRNVSFDELVDAYSESTRALIKGGSDLILIETIFDTL 188 Query: 194 NAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNC 253 NAKA FAVE++FE+ G PV+ISGTITDASGRTLSGQ TEAF+NA+RH KPI+ GLNC Sbjct: 189 NAKACAFAVESVFEEVGIILPVMISGTITDASGRTLSGQTTEAFYNALRHVKPISFGLNC 248 Query: 254 ALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVNLV 313 ALG E+R Y+ EM+RI++ VS +PNAGLPNAFGEYD +PE A ++ E+A++G +NL+ Sbjct: 249 ALGPDELREYVGEMSRISECNVSAHPNAGLPNAFGEYDLSPEDMAEHVKEWAESGFLNLI 308 Query: 314 GGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNITG 373 GGCCGT P HI ++A+ VEG PR+LP++PV+ RLSGLEPL IS +SLFVN+GERTN+TG Sbjct: 309 GGCCGTTPEHIRQMAEAVEGVTPRQLPDLPVSCRLSGLEPLTISKESLFVNVGERTNVTG 368 Query: 374 SARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPDIS 433 SARF+ LIK E YD ALSVA +QVE GAQ+IDINMDEGM+D A M +F L A+EP+IS Sbjct: 369 SARFKRLIKEELYDEALSVAREQVENGAQIIDINMDEGMLDAEACMVKFLNLCASEPEIS 428 Query: 434 RVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAFDE 493 +VPVM+DSSKWEVIEAGLK +QGK IVNSIS+KEG+EKFV +A+L R+YGAAV+VMAFDE Sbjct: 429 KVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVEQAKLVRRYGAAVIVMAFDE 488 Query: 494 KGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACA 553 GQAD ER+ EIC AY IL +EVGFP EDIIFDPN FA+ATGI+EH Y +DFIEA Sbjct: 489 VGQADTRERKVEICTNAYNILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYAVDFIEAVG 548 Query: 554 WIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPYDS 613 IK +LP ISGG+SNVSFSFRGNN VREAIHAVFL+H K G+DMGIVNAG L YD+ Sbjct: 549 DIKRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVNAGQLEIYDN 608 Query: 614 IDPELRERIEDVVLNRREDAAERLLEIAERF--NTKGKSEDPAAAEWRSLPVRERITHAL 671 + +LRE +EDVVLNRR+D+ ERLL+IA + GK ED +A EWR+ PV +R+ H+L Sbjct: 609 VPEDLREAVEDVVLNRRDDSTERLLDIATEYLERAVGKVEDKSALEWRTWPVEKRLEHSL 668 Query: 672 VKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSAR 731 VKGI + DTEE R RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVKSAR Sbjct: 669 VKGITDFIVEDTEEARVN----ASRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSAR 724 Query: 732 VMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTV 791 VMK+AVA+L PFI A K + TNG I++ATVKGDVHDIGKNIVGVVLQCNNY + Sbjct: 725 VMKQAVAHLEPFINATK------DVGATNGKILLATVKGDVHDIGKNIVGVVLQCNNYEI 778 Query: 792 VDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGGATT 851 +DLGVMV EKIL A+E + DIIGLSGLITPSLDEMV+ A MER+G ++PLLIGGATT Sbjct: 779 IDLGVMVSCEKILKVAKEENVDIIGLSGLITPSLDEMVHVAKEMERQGFKLPLLIGGATT 838 Query: 852 SRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERHSQK 911 S+AHTAVK+ S PVV+V +ASR+V V +LL ++ +P +E DY +R++H++K Sbjct: 839 SKAHTAVKIEQNYSEPVVYVNNASRAVGVCTSLLSNELKPAFVEKLDIDYDRVRDQHNRK 898 Query: 912 NERPM-LTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFNAWE 970 R +TLE+ARAN+ IDWD YTPP PA+ GV F+D+D+A LR+YIDW PFF W Sbjct: 899 KPRTKPVTLERARANKVAIDWDAYTPPAPAKP-GVHIFNDFDVATLRQYIDWTPFFMTWS 957 Query: 971 MKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIEVYT 1030 + G++P ILN+ GE A++L+ DA ++LD + +EK L A G+ FPAN+VGDDIEVYT Sbjct: 958 LVGKYPAILNHEEVGEEAKRLFKDANDLLDRVQKEKLLEARGMCAMFPANSVGDDIEVYT 1017 Query: 1031 DETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTKIV 1090 DE+R EVL LHNLRQQ E G N L D+IAPKD+G AD++G FAVT G+G + Sbjct: 1018 DESRTEVLKVLHNLRQQTEKPKGF-NYCLSDYIAPKDSGKADWIGGFAVTGGIGERELAD 1076 Query: 1091 EFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYVGIR 1150 E+K DDY+AI+++++ADRLAEAFAE +H+ VR++ WGY PDE+L N+ LI E+Y GIR Sbjct: 1077 EYKANGDDYNAIMIQAVADRLAEAFAEYLHKEVRKDIWGYSPDEELSNDDLIREKYQGIR 1136 Query: 1151 PAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFVVGR 1210 PAPGYPACPEHTEK TL+ELM V K + LT S AMWPGA+VSG YFSHP ++YF + + Sbjct: 1137 PAPGYPACPEHTEKGTLWELMGVEKAIDMSLTTSYAMWPGASVSGMYFSHPDARYFAIAQ 1196 Query: 1211 MAQDQVADYAKRKGWTLPEAERWLGPNL 1238 + QDQV YA RKGW + EAE+WLGPN+ Sbjct: 1197 IQQDQVDSYADRKGWDMLEAEKWLGPNI 1224 >tr|B7MJ00|B7MJ00_ECO45 Tax_Id=585035 (metH)SubName: Full=Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; EC=2.1.1.13;[Escherichia coli O45:K1] Length = 1227 Score = 1540 bits (3988), Expect = 0.0 Identities = 779/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ +EAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTSEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227 >tr|A1AII8|A1AII8_ECOK1 Tax_Id=405955 (metH)SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase;[Escherichia coli O1:K1 / APEC] Length = 1232 Score = 1540 bits (3988), Expect = 0.0 Identities = 779/1236 (63%), Positives = 947/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 11 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 70 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 71 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 130 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 131 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 190 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ +EAF+N++RHA+ + GL Sbjct: 191 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTSEAFYNSLRHAEALTFGL 250 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A+AG +N Sbjct: 251 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLN 310 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 311 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 370 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 371 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 430 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 431 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 490 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFPAEDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 491 DEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQDFIGA 550 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 551 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 610 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 611 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 669 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 670 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 725 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 726 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 779 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 780 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 839 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 840 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 899 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 900 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 957 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 958 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1017 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1018 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1076 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1077 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1136 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1137 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1196 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ E ERWL PNLGY+ E Sbjct: 1197 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1232 >tr|Q8X5Z8|Q8X5Z8_ECO57 Tax_Id=83334 (metH)SubName: Full=B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metF; SubName: Full=B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase;[Escherichia coli O157:H7] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B5Z0B1|B5Z0B1_ECO5E Tax_Id=444450 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|C6V1X2|C6V1X2_ECO5T Tax_Id=544404 (metH)SubName: Full=Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent;[Escherichia coli O157:H7] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|C3SHY2|C3SHY2_ECOLX Tax_Id=562 SubName: Full=B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase;[Escherichia coli] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B6ZVL4|B6ZVL4_ECO57 Tax_Id=502346 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. TW14588] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B3BTV8|B3BTV8_ECO57 Tax_Id=478007 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC508] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B3BBX0|B3BBX0_ECO57 Tax_Id=478008 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC869] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B3AZV3|B3AZV3_ECO57 Tax_Id=478006 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC4501] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B3AH12|B3AH12_ECO57 Tax_Id=478005 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC4486] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B3A6K2|B3A6K2_ECO57 Tax_Id=478004 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC4401] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B2PJ51|B2PJ51_ECO57 Tax_Id=444453 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC4076] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B2P9M2|B2P9M2_ECO57 Tax_Id=444452 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC4113] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B2NQG8|B2NQG8_ECO57 Tax_Id=444451 (metH)SubName: Full=Methionine synthase; EC=2.1.1.13;[Escherichia coli O157:H7 str. EC4196] Length = 1227 Score = 1539 bits (3985), Expect = 0.0 Identities = 779/1236 (63%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI DDSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKWEVIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPAELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANAQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ + Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227 >tr|B7NRU9|B7NRU9_ECO7I Tax_Id=585057 (metH)SubName: Full=Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; EC=2.1.1.13;[Escherichia coli O7:K1] Length = 1227 Score = 1538 bits (3982), Expect = 0.0 Identities = 778/1236 (62%), Positives = 945/1236 (76%), Gaps = 20/1236 (1%) Query: 14 DALTAALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLTQPQIIE 73 + L A L +RI+V+DG MGT IQ R +EA +RGERF DWP DL GNNDLL L++P++I Sbjct: 6 EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65 Query: 74 GIHREYLQAGADILETNTFNANAVSLSDYDMAELAYELNYXXXXXXXXXXDEFS--TPEK 131 IH Y +AGADI+ETNTFN+ ++++DY M L+ E+N+ DE++ TPEK Sbjct: 66 AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125 Query: 132 PRYVAGALGPTTRTASISPDVNDPGARNVSYDQLVAAYLEAANGLVDGGADIIIIETIFD 191 PRYVAG LGPT RTASISPDVNDP RN+++DQLVAAY E+ LV+GGAD+I+IET+FD Sbjct: 126 PRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFD 185 Query: 192 SLNAKAAVFAVETLFEDRGRRWPVIISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGL 251 +LNAKAAVFAV+T FE G P++ISGTITDASGRTLSGQ TEAF+N++RHA+ + GL Sbjct: 186 TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245 Query: 252 NCALGAPEMRPYIAEMARIADTFVSCYPNAGLPNAFGEYDETPEHQAGYIAEFADAGLVN 311 NCALG E+R Y+ E++RIA+ +V+ +PNAGLPNAFGEYD + A I E+A AG +N Sbjct: 246 NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305 Query: 312 LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLNISDDSLFVNIGERTNI 371 +VGGCCGT P HIA +++ VEG APR+LPEIPVA RLSGLEPLNI +DSLFVN+GERTN+ Sbjct: 306 IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365 Query: 372 TGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTKLIAAEPD 431 TGSA+F+ LIK E Y AL VA QQVE GAQ+IDINMDEGM+D AAM RF LIA EPD Sbjct: 366 TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425 Query: 432 ISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISMKEGEEKFVREARLCRKYGAAVVVMAF 491 I+RVP+MIDSSKW+VIE GLK +QGK IVNSISMKEG + F+ A+L R+YGAAVVVMAF Sbjct: 426 IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485 Query: 492 DEKGQADNLERRKEICGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEA 551 DE+GQAD R+ EIC RAY+ILTEEVGFP EDIIFDPN FA+ATGIEEH Y DFI A Sbjct: 486 DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545 Query: 552 CAWIKENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAGALVPY 611 C IK LP ISGG+SNVSFSFRGN+PVREAIHAVFL++AI+ G+DMGIVNAG L Y Sbjct: 546 CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605 Query: 612 DSIDPELRERIEDVVLNRREDAAERLLEIAERFNTKGKSEDPA---AAEWRSLPVRERIT 668 D + ELR+ +EDV+LNRR+D ERLLE+AE++ K++D A AEWRS V +R+ Sbjct: 606 DDLPTELRDAVEDVILNRRDDGTERLLELAEKYR-GSKTDDTANTQQAEWRSWEVNKRLE 664 Query: 669 HALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVK 728 ++LVKGI ++ DTEE R + RPIEVIEGPLMDGMNVVGDLFG GKMFLPQVVK Sbjct: 665 YSLVKGITEFIEQDTEEARQQAT----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK 720 Query: 729 SARVMKKAVAYLLPFIEAEKAQSGSTEQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNN 788 SARVMK+AVAYL PFIEA K EQ KTNG +++ATVKGDVHDIGKNIVGVVLQCNN Sbjct: 721 SARVMKQAVAYLEPFIEASK------EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNN 774 Query: 789 YTVVDLGVMVPAEKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMEREGMQIPLLIGG 848 Y +VDLGVMVPAEKIL A+E +AD+IGLSGLITPSLDEMVN A MER+G IPLLIGG Sbjct: 775 YEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGG 834 Query: 849 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATAADYAALRERH 908 ATTS+AHTAVK+ SGP V+V++ASR+V V AALL D QR + T +Y +R +H Sbjct: 835 ATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQH 894 Query: 909 SQKNER-PMLTLEKARANRTPIDWDGYTPPLPAQGLGVREFHDYDLAELREYIDWQPFFN 967 +K R P +TLE AR N DW YTPP+ A LGV+E + + LR YIDW PFF Sbjct: 895 GRKKPRTPPVTLEAARDNDFAFDWQAYTPPV-AHRLGVQEV-EASIETLRNYIDWTPFFM 952 Query: 968 AWEMKGRFPDILNNPATGEAARKLYNDAQEMLDTLIREKWLTANGVIGFFPANAVGDDIE 1027 W + G++P IL + G A++L+ DA +MLD L EK L GV+G FPAN VGDDIE Sbjct: 953 TWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIE 1012 Query: 1028 VYTDETRAEVLTTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQT 1087 +Y DETR V+ H+LRQQ E + G N L DF+APK +G ADY+GAFAVT GL Sbjct: 1013 IYRDETRTHVINVSHHLRQQTE-KTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDA 1071 Query: 1088 KIVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWGYQPDEQLDNEALIGERYV 1147 F+ DDY+ I+++++ADRLAEAFAE +H+RVR+ +WGY P+E L NE LI E Y Sbjct: 1072 LADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQ 1131 Query: 1148 GIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTESMAMWPGAAVSGWYFSHPQSQYFV 1207 GIRPAPGYPACPEHTEK T++EL++V K TG++LTES AMWPGA+VSGWYFSHP S+Y+ Sbjct: 1132 GIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191 Query: 1208 VGRMAQDQVADYAKRKGWTLPEAERWLGPNLGYNPE 1243 V ++ +DQV DYA+RKG ++ + ERWL PNLGY+ E Sbjct: 1192 VAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAE 1227 Database: Amellifera_nr Posted date: Feb 5, 2010 5:10 AM Number of letters in database: 3,846,993,858 Number of sequences in database: 11,275,203 Lambda K H 0.318 0.135 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11275203 Number of Hits to DB: 9,490,037,714 Number of extensions: 420836619 Number of successful extensions: 1024981 Number of sequences better than 10.0: 2908 Number of HSP's gapped: 1014321 Number of HSP's successfully gapped: 3084 Length of query: 1244 Length of database: 3,846,993,858 Length adjustment: 150 Effective length of query: 1094 Effective length of database: 2,155,713,408 Effective search space: 2358350468352 Effective search space used: 2358350468352 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 87 (38.1 bits)