BLASTP 2.2.16 [Mar-25-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= MMAR_5138 (934 letters) Database: Amellifera_nr; Agambiae_nr; Cfamiliaris_nr; Cbriggsae_nr; Celegans_nr; swiss_varsplic_nr; Dmelanogaster_nr; Drerio_nr; trembl_nr; Ggallus_nr; Hsapiens_nr; Mmusculus_nr; Ptroglodytes_nr; Rnorvegicus_nr; Tnigroviridis_nr; swiss_nr; wormpep_nr; yeastpep_nr; Aaegypti_nr; Btaurus_nr; Cintestinalis_nr; Mdomestica_nr; Mmulatta_nr; Scerevisiae_nr; Xtropicalis_nr; Csavignyi_nr; Dnovemcinctus_nr; Etelfairi_nr; Gaculeatus_nr; Lafricana_nr; Ocuniculus_nr; Trubripes_nr; Pberghei_nr; Pchabaudi_nr; Pfalciparum_nr; Pvivax_nr; Pyoelii_nr; Tgondii_nr; Pknowlesi_nr; Cporcellus_nr; Eeuropaeus_nr; Fcatus_nr; Mlucifugus_nr; Mmurinus_nr; Oanatinus_nr; Ogarnettii_nr; Olatipes_nr; Oprinceps_nr; Saraneus_nr; Stridecemlineatus_nr; Tbelangeri_nr; Ecaballus_nr; Ppygmaeus_nr 11,275,203 sequences; 3,846,993,858 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tr|B2HJ79|B2HJ79_MYCMM Tax_Id=216594 (topA)RecName: Full=DNA top... 1704 0.0 tr|A0PV84|A0PV84_MYCUA Tax_Id=362242 (topA)RecName: Full=DNA top... 1689 0.0 tr|A0QA61|A0QA61_MYCA1 Tax_Id=243243 (topA)RecName: Full=DNA top... 1546 0.0 tr|Q744B6|Q744B6_MYCPA Tax_Id=1770 (topA)RecName: Full=DNA topoi... 1541 0.0 sp|P0A620|TOP1_MYCTU Tax_Id=1773 (topA)RecName: Full=DNA topoiso... 1524 0.0 sp|P0A621|TOP1_MYCBO Tax_Id=1765 (topA)RecName: Full=DNA topoiso... 1524 0.0 tr|C6DMU7|C6DMU7_MYCTK Tax_Id=478434 RecName: Full=DNA topoisome... 1524 0.0 tr|A5U8X0|A5U8X0_MYCTA Tax_Id=419947 (topA)RecName: Full=DNA top... 1524 0.0 tr|A4KMB8|A4KMB8_MYCTU Tax_Id=395095 RecName: Full=DNA topoisome... 1524 0.0 tr|A2VM29|A2VM29_MYCTU Tax_Id=348776 RecName: Full=DNA topoisome... 1524 0.0 tr|A5WTL1|A5WTL1_MYCTF Tax_Id=336982 RecName: Full=DNA topoisome... 1523 0.0 tr|C1AI98|C1AI98_MYCBT Tax_Id=561275 (topA)RecName: Full=DNA top... 1522 0.0 tr|A1KPX5|A1KPX5_MYCBP Tax_Id=410289 (topA)RecName: Full=DNA top... 1522 0.0 sp|O69548|TOP1_MYCLE Tax_Id=1769 (topA)RecName: Full=DNA topoiso... 1470 0.0 tr|B8ZU27|B8ZU27_MYCLB Tax_Id=561304 (topA)RecName: Full=DNA top... 1470 0.0 tr|A0R5D9|A0R5D9_MYCS2 Tax_Id=246196 (topA)RecName: Full=DNA top... 1431 0.0 tr|Q1B2I4|Q1B2I4_MYCSS Tax_Id=164756 RecName: Full=DNA topoisome... 1420 0.0 tr|A3Q719|A3Q719_MYCSJ Tax_Id=164757 RecName: Full=DNA topoisome... 1420 0.0 tr|A1UML4|A1UML4_MYCSK Tax_Id=189918 RecName: Full=DNA topoisome... 1420 0.0 tr|A1TG67|A1TG67_MYCVP Tax_Id=350058 RecName: Full=DNA topoisome... 1405 0.0 tr|A4T5R5|A4T5R5_MYCGI Tax_Id=350054 RecName: Full=DNA topoisome... 1403 0.0 tr|B1MGQ4|B1MGQ4_MYCA9 Tax_Id=561007 RecName: Full=DNA topoisome... 1374 0.0 tr|Q5Z2Y2|Q5Z2Y2_NOCFA Tax_Id=37329 (topA)RecName: Full=DNA topo... 1306 0.0 tr|C1BA07|C1BA07_RHOOB Tax_Id=632772 (topA)RecName: Full=DNA top... 1278 0.0 tr|Q0S8J3|Q0S8J3_RHOSR Tax_Id=101510 RecName: Full=DNA topoisome... 1276 0.0 tr|C0ZNG9|C0ZNG9_RHOE4 Tax_Id=234621 (topA)RecName: Full=DNA top... 1252 0.0 tr|C3JWG9|C3JWG9_RHOER Tax_Id=596309 RecName: Full=DNA topoisome... 1252 0.0 tr|C6WFC8|C6WFC8_ACTMD Tax_Id=446462 RecName: Full=DNA topoisome... 1228 0.0 tr|C7MQK9|C7MQK9_SACVD Tax_Id=471857 RecName: Full=DNA topoisome... 1217 0.0 tr|A4F6Q1|A4F6Q1_SACEN Tax_Id=405948 (topA)RecName: Full=DNA top... 1207 0.0 tr|C2AJX7|C2AJX7_TSUPA Tax_Id=521096 RecName: Full=DNA topoisome... 1204 0.0 tr|C8X984|C8X984_NAKMY Tax_Id=479431 SubName: Full=DNA topoisome... 1186 0.0 tr|D0LEI6|D0LEI6_GORB4 Tax_Id=526226 SubName: Full=DNA topoisome... 1139 0.0 tr|Q8FSS5|Q8FSS5_COREF Tax_Id=152794 RecName: Full=DNA topoisome... 1119 0.0 tr|C8NKH1|C8NKH1_COREF Tax_Id=196164 (topA)SubName: Full=Dna top... 1119 0.0 tr|Q8NTJ8|Q8NTJ8_CORGL Tax_Id=1718 (topA)RecName: Full=DNA topoi... 1084 0.0 tr|A4QAW2|A4QAW2_CORGB Tax_Id=340322 RecName: Full=DNA topoisome... 1084 0.0 tr|B1VI08|B1VI08_CORU7 Tax_Id=504474 RecName: Full=DNA topoisome... 1076 0.0 tr|C8RV02|C8RV02_CORJE Tax_Id=525262 (topA)SubName: Full=DNA top... 1070 0.0 tr|Q4JSS2|Q4JSS2_CORJK Tax_Id=306537 (topA)RecName: Full=DNA top... 1065 0.0 tr|C3PJV8|C3PJV8_CORA7 Tax_Id=548476 (topA)RecName: Full=DNA top... 1065 0.0 tr|C8NXE9|C8NXE9_9CORY Tax_Id=585529 (topA)SubName: Full=DNA top... 1064 0.0 tr|C2GG61|C2GG61_9CORY Tax_Id=548478 RecName: Full=DNA topoisome... 1063 0.0 tr|C0VRF5|C0VRF5_9CORY Tax_Id=548477 RecName: Full=DNA topoisome... 1062 0.0 tr|A8LF30|A8LF30_FRASN Tax_Id=298653 RecName: Full=DNA topoisome... 1053 0.0 tr|C5V9G5|C5V9G5_9CORY Tax_Id=553207 RecName: Full=DNA topoisome... 1053 0.0 tr|C0E5R1|C0E5R1_9CORY Tax_Id=566549 RecName: Full=DNA topoisome... 1051 0.0 tr|Q0RBI4|Q0RBI4_FRAAA Tax_Id=326424 (topA)RecName: Full=DNA top... 1046 0.0 tr|C2BKM3|C2BKM3_9CORY Tax_Id=525264 RecName: Full=DNA topoisome... 1045 0.0 tr|C6R7P2|C6R7P2_9CORY Tax_Id=553206 RecName: Full=DNA topoisome... 1043 0.0 >tr|B2HJ79|B2HJ79_MYCMM Tax_Id=216594 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium marinum] Length = 934 Score = 1704 bits (4414), Expect = 0.0 Identities = 879/934 (94%), Positives = 880/934 (94%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA Sbjct: 1 MADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVS ATDGDREGE Sbjct: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGE 120 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE Sbjct: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP Sbjct: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK Sbjct: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 420 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY Sbjct: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 420 Query: 421 ELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG Sbjct: 421 ELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG 480 Query: 481 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPI 540 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPI Sbjct: 481 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPI 540 Query: 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR Sbjct: 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR 600 Query: 601 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG 660 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG Sbjct: 601 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG 660 Query: 661 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHE 720 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHE Sbjct: 661 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHE 720 Query: 721 IVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDA 780 IVAKDGRYGPYVTEIL RSGSLLRSMDLQTITLEDA Sbjct: 721 IVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKTKKATGPKPRSGSLLRSMDLQTITLEDA 780 Query: 781 LKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAE 840 LKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAE Sbjct: 781 LKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAE 840 Query: 841 PKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDER 900 PKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDER Sbjct: 841 PKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDER 900 Query: 901 ASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA 934 ASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA Sbjct: 901 ASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA 934 >tr|A0PV84|A0PV84_MYCUA Tax_Id=362242 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium ulcerans] Length = 934 Score = 1689 bits (4375), Expect = 0.0 Identities = 874/934 (93%), Positives = 875/934 (93%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA Sbjct: 1 MADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVS ATDGDREGE Sbjct: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGE 120 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE Sbjct: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFR ASYWDIVATLDASVSDPKAAPP Sbjct: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRRASYWDIVATLDASVSDPKAAPP 240 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK Sbjct: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 420 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY Sbjct: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 420 Query: 421 ELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGTTLSL IGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG Sbjct: 421 ELIWQRTVASQMADARGTTLSLWIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG 480 Query: 481 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPI 540 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNP ARYTEASLVKAFEELGIGRPSTYTPI Sbjct: 481 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNPLARYTEASLVKAFEELGIGRPSTYTPI 540 Query: 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR Sbjct: 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR 600 Query: 601 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG 660 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG Sbjct: 601 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG 660 Query: 661 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHE 720 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGID ESGHE Sbjct: 661 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDAESGHE 720 Query: 721 IVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDA 780 IVAKDGRYGPYVTEIL RSGSLLRSMDLQTITLEDA Sbjct: 721 IVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKSKKATAPKPRSGSLLRSMDLQTITLEDA 780 Query: 781 LKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAE 840 LKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAE Sbjct: 781 LKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAE 840 Query: 841 PKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDER 900 PKRSGRQSASAPPLRELGTDAASGK MVIKDGRFGPYVTDGETNASLRKGDEVASITDER Sbjct: 841 PKRSGRQSASAPPLRELGTDAASGKAMVIKDGRFGPYVTDGETNASLRKGDEVASITDER 900 Query: 901 ASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA 934 ASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA Sbjct: 901 ASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA 934 >tr|A0QA61|A0QA61_MYCA1 Tax_Id=243243 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium avium] Length = 932 Score = 1546 bits (4004), Expect = 0.0 Identities = 788/934 (84%), Positives = 831/934 (88%), Gaps = 4/934 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPK K LVIVESPTKARKLA YLG RYIVESSRGHIRDLPRAAA Sbjct: 1 MADPKLKENTSGGNGSRRR---LVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAA 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KSEPWARLGVNVDADFEPLYIISPEKK VS ATDGDREGE Sbjct: 58 DVPAKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKP +PVKRMVFHEITEPAILEAAENPRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IVQRERDRMAFRSASYWDIVA LDASVSDP+A+PP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLTSVDGLRVATGRDFDS G LRKADEV VLDE +A LA GL GAQLSVASVEEK Sbjct: 238 TFAARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPY PFMTSTLQQEAGRKLRFS ERTMSIAQRLYENGYITYMRTDSTTLS SAINA Sbjct: 298 PYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 420 ARTQARQLYGEEYV+ SPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY Sbjct: 358 ARTQARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 417 Query: 421 ELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGTTLSLRIGG AG++QVVFSASGRT+TFPGFLKAYVETVDEL G Sbjct: 418 ELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFPGFLKAYVETVDELAG 477 Query: 481 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPI 540 GEADDAE RLP LT GQRLDA+ELTPDGH TNPP RYTEASLVKA EELGIGRPSTY+ I Sbjct: 478 GEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSI 537 Query: 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELDAIASGQERR Sbjct: 538 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERR 597 Query: 601 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG 660 TDWLNNFYFGG+HGV+DS+AR+GGLKKLVGVNLEGIDAREVNSIKLFDDEQGRP+YVRVG Sbjct: 598 TDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVG 657 Query: 661 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHE 720 KNGPYLER +TG+DGEPTPQRANLNDSLTPDELTL +AE+LFATPQEGRVLG+DP +GHE Sbjct: 658 KNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHE 717 Query: 721 IVAKDGRYGPYVTEIL-XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLED 779 IVAKDGRYGPYV E+L R+ SLLR+MDLQT+TLED Sbjct: 718 IVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLED 777 Query: 780 ALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYA 839 AL+LLSLPRVVG DP +GEEITAQNGRYGPYLKRG DSRSLATE+Q+F ITL+EALKIYA Sbjct: 778 ALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLATEEQLFDITLEEALKIYA 837 Query: 840 EPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDE 899 EPKR GRQ A+APPLRELG D A+GKPMVIKDGRFGPYVTDGETNASLRKGD+V S+TD+ Sbjct: 838 EPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQ 897 Query: 900 RASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 RA+ELLADRRARGP KR AKKT+RK+PAKKA KR Sbjct: 898 RAAELLADRRARGPAKRTAKKTSRKAPAKKAAKR 931 >tr|Q744B6|Q744B6_MYCPA Tax_Id=1770 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium paratuberculosis] Length = 932 Score = 1541 bits (3989), Expect = 0.0 Identities = 785/934 (84%), Positives = 830/934 (88%), Gaps = 4/934 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPK K LVIVESPTKARKLA YLG RYIVESSRGHIRDLPRAAA Sbjct: 1 MADPKLKENTSGGNGSRRR---LVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAA 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KSEPWARLGVNVDADFEPLYIISPEKK VS ATDGDREGE Sbjct: 58 DVPAKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKP +PVKRMVFHEITEPAILEAAENPRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 V+PVLWKKVAPKLSAGRVQSVATR+IVQRERDRMAFRSASYWDIVA LDASVSDP+A+PP Sbjct: 178 VTPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLTSVDGLRVATGRDFDS G LRKADEV VLDE +A LA GL GAQLSVASVEEK Sbjct: 238 TFAARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPY PFMTSTLQQEAGRKLRFS ERTMSIAQRLYENGYITYMRTDSTTLS SAINA Sbjct: 298 PYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 420 ARTQARQLYGEEYV+ SPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY Sbjct: 358 ARTQARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLY 417 Query: 421 ELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVG 480 ELIWQRTVASQMADARGTTLSLRIGG AG++QVVFSASGRT+TF GFLKAYVETVDEL G Sbjct: 418 ELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFAGFLKAYVETVDELAG 477 Query: 481 GEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPI 540 GEADDAE RLP LT GQRLDA+ELTPDGH TNPP RYTEASLVKA EELGIGRPSTY+ I Sbjct: 478 GEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSI 537 Query: 541 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERR 600 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELDAIASGQERR Sbjct: 538 IKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERR 597 Query: 601 TDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVG 660 TDWLNNFYFGG+HGV+DS+AR+GGLKKLVGVNLEGIDAREVNSIKLFDDEQGRP+YVRVG Sbjct: 598 TDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVG 657 Query: 661 KNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHE 720 KNGPYLER +TG+DGEPTPQRANLNDSLTPDELTL +AE+LFATPQEGRVLG+DP +GHE Sbjct: 658 KNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHE 717 Query: 721 IVAKDGRYGPYVTEIL-XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLED 779 IVAKDGRYGPYV E+L R+ SLLR+MDLQT+TLED Sbjct: 718 IVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLED 777 Query: 780 ALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYA 839 AL+LLSLPRVVG DP +GEEITAQNGRYGPYLKRG DSRSLA+E+Q+F ITL+EALKIYA Sbjct: 778 ALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLASEEQLFDITLEEALKIYA 837 Query: 840 EPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDE 899 EPKR GRQ A+APPLRELG D A+GKPMVIKDGRFGPYVTDGETNASLRKGD+V S+TD+ Sbjct: 838 EPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQ 897 Query: 900 RASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 RA+ELLADRRARGP KR AKKT+RK+PAKKA KR Sbjct: 898 RAAELLADRRARGPAKRTAKKTSRKAPAKKAAKR 931 >sp|P0A620|TOP1_MYCTU Tax_Id=1773 (topA)RecName: Full=DNA topoisomerase 1; EC=5.99.1.2; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Untwisting enzyme; AltName: Full=Swivelase;[Mycobacterium tuberculosis] Length = 934 Score = 1524 bits (3945), Expect = 0.0 Identities = 780/936 (83%), Positives = 824/936 (88%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >sp|P0A621|TOP1_MYCBO Tax_Id=1765 (topA)RecName: Full=DNA topoisomerase 1; EC=5.99.1.2; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Untwisting enzyme; AltName: Full=Swivelase;[Mycobacterium bovis] Length = 934 Score = 1524 bits (3945), Expect = 0.0 Identities = 780/936 (83%), Positives = 824/936 (88%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >tr|C6DMU7|C6DMU7_MYCTK Tax_Id=478434 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium tuberculosis] Length = 934 Score = 1524 bits (3945), Expect = 0.0 Identities = 780/936 (83%), Positives = 824/936 (88%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >tr|A5U8X0|A5U8X0_MYCTA Tax_Id=419947 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium tuberculosis] Length = 934 Score = 1524 bits (3945), Expect = 0.0 Identities = 780/936 (83%), Positives = 824/936 (88%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >tr|A4KMB8|A4KMB8_MYCTU Tax_Id=395095 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium tuberculosis str. Haarlem] Length = 934 Score = 1524 bits (3945), Expect = 0.0 Identities = 780/936 (83%), Positives = 824/936 (88%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >tr|A2VM29|A2VM29_MYCTU Tax_Id=348776 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium tuberculosis C] Length = 934 Score = 1524 bits (3945), Expect = 0.0 Identities = 780/936 (83%), Positives = 824/936 (88%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >tr|A5WTL1|A5WTL1_MYCTF Tax_Id=336982 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium tuberculosis] Length = 934 Score = 1523 bits (3943), Expect = 0.0 Identities = 779/936 (83%), Positives = 824/936 (88%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKKLVG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNAS+RKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASMRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >tr|C1AI98|C1AI98_MYCBT Tax_Id=561275 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium bovis] Length = 934 Score = 1522 bits (3941), Expect = 0.0 Identities = 779/936 (83%), Positives = 823/936 (87%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKK VG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKFVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >tr|A1KPX5|A1KPX5_MYCBP Tax_Id=410289 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium bovis] Length = 934 Score = 1522 bits (3941), Expect = 0.0 Identities = 779/936 (83%), Positives = 823/936 (87%), Gaps = 6/936 (0%) Query: 1 LADPKTKXXXXXXXXXXXXXXXLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAA 60 +ADPKTK LVIVESPTKARKLA YLG YIVESSRGHIRDLPRAA+ Sbjct: 1 MADPKTKGRGSGGNGSGRR---LVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAAS 57 Query: 61 DVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGE 120 DVPAK+KS+PWARLGVNVDADFEPLYIISPEK+S VS ATDGDREGE Sbjct: 58 DVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGE 117 Query: 121 AIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYE 180 AIAWHLLETLKPR+PVKRMVFHEITEPAI AAE+PRDLD+DLVDAQETRRILDRLYGYE Sbjct: 118 AIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYE 177 Query: 181 VSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPP 240 VSPVLWKKVAPKLSAGRVQSVATR+IV RERDRMAFRSA+YWDI+A LDASVSDP AAPP Sbjct: 178 VSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPP 237 Query: 241 TFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEK 300 TF ARLT+V G RVATGRDFDSLGTLRK DEV VLDE A ALA GL G QL+VAS EEK Sbjct: 238 TFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEK 297 Query: 301 PYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINA 360 PY+RRPYPPFMTSTLQQEA RKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINA Sbjct: 298 PYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 357 Query: 361 ARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG---DEF 417 ARTQARQLYG+EYVA +PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG D+F Sbjct: 358 ARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDF 417 Query: 418 RLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDE 477 RLYELIWQRTVASQMADARG TLSLRI G +G Q+VVFSA+GRTLTFPGFLKAYVETVDE Sbjct: 418 RLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDE 477 Query: 478 LVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTY 537 LVGGEADDAERRLP+LTPGQRLD VELTPDGH TNPPARYTEASLVKA EELGIGRPSTY Sbjct: 478 LVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537 Query: 538 TPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQ 597 + IIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G Sbjct: 538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGN 597 Query: 598 ERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYV 657 ERRT+WLNNFYFGGDHGV DSVAR+GGLKK VG+NLEGIDAREVNSIKLFDD GRPIYV Sbjct: 598 ERRTNWLNNFYFGGDHGVPDSVARSGGLKKFVGINLEGIDAREVNSIKLFDDTHGRPIYV 657 Query: 658 RVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPES 717 RVGKNGPYLER + G+ GEPTPQRANL+DS+TPDELTL +AEELFATPQ+GR LG+DPE+ Sbjct: 658 RVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPET 717 Query: 718 GHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITL 777 GHEIVA++GR+GPYVTEIL R+GSLLRSMDLQT+TL Sbjct: 718 GHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTL 777 Query: 778 EDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKI 837 EDAL+LLSLPRVVG DPASGEEITAQNGRYGPYLKRG DSRSL TEDQIF+ITLDEALKI Sbjct: 778 EDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKI 837 Query: 838 YAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASIT 897 YAEPKR GRQSASAPPLRELGTD ASGKPMVIKDGRFGPYVTDGETNASLRKGD+VASIT Sbjct: 838 YAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASIT 897 Query: 898 DERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 DERA+ELLADRRARGP KR A+K RK PAKKA KR Sbjct: 898 DERAAELLADRRARGPAKRPARKAARKVPAKKAAKR 933 >sp|O69548|TOP1_MYCLE Tax_Id=1769 (topA)RecName: Full=DNA topoisomerase 1; EC=5.99.1.2; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Untwisting enzyme; AltName: Full=Swivelase;[Mycobacterium leprae] Length = 947 Score = 1470 bits (3805), Expect = 0.0 Identities = 755/921 (81%), Positives = 804/921 (87%), Gaps = 10/921 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARKL+GYLG YIVESSRGHIRDLPR AADVPAKFKSEPWARLGVNVDADF Sbjct: 18 LVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADF 77 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYII+PEKKS V+ ATDGDREGEAIAWHL++TLKPRVPVKRMVFH Sbjct: 78 EPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVFH 137 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITE AIL AA +PR+LD+DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 138 EITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 197 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRERDRMAF SA YWDIVA LDASVSDP A P TFVARLT+VDGLRVATGRDF + Sbjct: 198 TRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGA 257 Query: 263 LGTLR---KADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEA 319 +GTLR + ++ VLD+ A LA GL GAQL+VAS EEK Y+RRPYPPFMTSTLQQEA Sbjct: 258 MGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEA 317 Query: 320 GRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPR 379 GRKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYV+ SPR Sbjct: 318 GRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPR 377 Query: 380 QYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTT 439 QYTRKVKNAQEAHEAIRPAGETFATPDAV ELDGDEFR+YEL+W+RTVASQMADARGTT Sbjct: 378 QYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTT 437 Query: 440 LSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRL 499 LSLRI G AGEQ VVFSASGRTLTFPGFLKAYVETVDEL GGEADDAERRLP+LT GQ L Sbjct: 438 LSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLL 497 Query: 500 DAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVP 559 D ++LTPDGH TNPPARYTEASLVKA EELGIGRPSTY+ IIKT+QDRGYV KKGSALVP Sbjct: 498 DVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVP 557 Query: 560 SWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSV 619 SWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G E+RT+WLNNFYFGG+HGVSDS+ Sbjct: 558 SWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSI 617 Query: 620 ARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTP 679 AR+GGLKKLVGVN+EGIDAREVNSIKLFDDE GRP+YVRVGK GPYLER + G+DGE TP Sbjct: 618 ARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTP 677 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL--- 736 QRANLN +LTPDELTL +AEELFATP EGRVLG+DPE+GHEIVAKDGRYGPYVTE+L Sbjct: 678 QRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKH 737 Query: 737 ---XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTD 793 R+GSLLRSMDLQTITLEDALKLL LPRVVG D Sbjct: 738 DDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVD 797 Query: 794 PASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPP 853 PASGEEITAQNGRYGPYLKRG DSR L TEDQ+F ITLDEALKIYAEPKR+GRQS S PP Sbjct: 798 PASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPP 857 Query: 854 LRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGP 913 LRELGTD SGKPM+IKDGRFGPYVTDGETNASLRKGD+V SITDERA+ELLADRRARGP Sbjct: 858 LRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGP 917 Query: 914 VKRAAKKTTRKSPAKKAVKRA 934 VKR AKK RK PAKKA + A Sbjct: 918 VKRPAKK-ARKVPAKKAARLA 937 >tr|B8ZU27|B8ZU27_MYCLB Tax_Id=561304 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium leprae] Length = 947 Score = 1470 bits (3805), Expect = 0.0 Identities = 755/921 (81%), Positives = 804/921 (87%), Gaps = 10/921 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARKL+GYLG YIVESSRGHIRDLPR AADVPAKFKSEPWARLGVNVDADF Sbjct: 18 LVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADF 77 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYII+PEKKS V+ ATDGDREGEAIAWHL++TLKPRVPVKRMVFH Sbjct: 78 EPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVFH 137 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITE AIL AA +PR+LD+DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 138 EITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 197 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRERDRMAF SA YWDIVA LDASVSDP A P TFVARLT+VDGLRVATGRDF + Sbjct: 198 TRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGA 257 Query: 263 LGTLR---KADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEA 319 +GTLR + ++ VLD+ A LA GL GAQL+VAS EEK Y+RRPYPPFMTSTLQQEA Sbjct: 258 MGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEA 317 Query: 320 GRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPR 379 GRKLRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYV+ SPR Sbjct: 318 GRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPR 377 Query: 380 QYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTT 439 QYTRKVKNAQEAHEAIRPAGETFATPDAV ELDGDEFR+YEL+W+RTVASQMADARGTT Sbjct: 378 QYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTT 437 Query: 440 LSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRL 499 LSLRI G AGEQ VVFSASGRTLTFPGFLKAYVETVDEL GGEADDAERRLP+LT GQ L Sbjct: 438 LSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLL 497 Query: 500 DAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVP 559 D ++LTPDGH TNPPARYTEASLVKA EELGIGRPSTY+ IIKT+QDRGYV KKGSALVP Sbjct: 498 DVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVP 557 Query: 560 SWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSV 619 SWVAFAVTGLLEQHFG LVDY FTAAMEDELD IA+G E+RT+WLNNFYFGG+HGVSDS+ Sbjct: 558 SWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSI 617 Query: 620 ARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTP 679 AR+GGLKKLVGVN+EGIDAREVNSIKLFDDE GRP+YVRVGK GPYLER + G+DGE TP Sbjct: 618 ARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTP 677 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL--- 736 QRANLN +LTPDELTL +AEELFATP EGRVLG+DPE+GHEIVAKDGRYGPYVTE+L Sbjct: 678 QRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKH 737 Query: 737 ---XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTD 793 R+GSLLRSMDLQTITLEDALKLL LPRVVG D Sbjct: 738 DDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVD 797 Query: 794 PASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPP 853 PASGEEITAQNGRYGPYLKRG DSR L TEDQ+F ITLDEALKIYAEPKR+GRQS S PP Sbjct: 798 PASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPP 857 Query: 854 LRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGP 913 LRELGTD SGKPM+IKDGRFGPYVTDGETNASLRKGD+V SITDERA+ELLADRRARGP Sbjct: 858 LRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGP 917 Query: 914 VKRAAKKTTRKSPAKKAVKRA 934 VKR AKK RK PAKKA + A Sbjct: 918 VKRPAKK-ARKVPAKKAARLA 937 >tr|A0R5D9|A0R5D9_MYCS2 Tax_Id=246196 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium smegmatis] Length = 936 Score = 1431 bits (3705), Expect = 0.0 Identities = 732/918 (79%), Positives = 792/918 (86%), Gaps = 7/918 (0%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG Y+VESSRGHIRDLPR AADVPAKFKSEPWARLGVNVD +F Sbjct: 17 LVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRNAADVPAKFKSEPWARLGVNVDQNF 76 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYI+SPEKKS V+ ATDGDREGEAIAWHLLETLKPRVPVKRMVFH Sbjct: 77 EPLYIVSPEKKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVFH 136 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAENPRDLD+ LVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 137 EITEPAIRNAAENPRDLDIALVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 196 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAF SASYWD+ A LDASVSDP A+PP F A+L +VDG RVATGRDFDS Sbjct: 197 TRIIVQRERERMAFHSASYWDVTAELDASVSDPSASPPKFTAKLNTVDGRRVATGRDFDS 256 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 LG L++ DEV VLDEA A ALA+GL GAQL+V SVE+KPY+RRPY PFMTSTLQQEA RK Sbjct: 257 LGQLKRPDEVLVLDEASAGALASGLRGAQLAVTSVEQKPYTRRPYAPFMTSTLQQEAARK 316 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRFS ERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYV SPRQYT Sbjct: 317 LRFSSERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQYT 376 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + LD DEFRLYELIWQRTVASQMADARGTTLSL Sbjct: 377 RKVKNAQEAHEAIRPAGDVFQTPGQLHSALDTDEFRLYELIWQRTVASQMADARGTTLSL 436 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RIGGSA +QVVF+ASGRT+TFPGFLKAYVE++DEL GGE+DDAE RLPNLT GQR+DA Sbjct: 437 RIGGSASSGEQVVFNASGRTITFPGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDA 496 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 +L+ DGH T+PPARYTEASL+KA EELGIGRPSTY+ IIKTIQDRGYV KKGSALVPSW Sbjct: 497 ADLSADGHQTSPPARYTEASLIKALEELGIGRPSTYSSIIKTIQDRGYVQKKGSALVPSW 556 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLEQHFG LVDY FTAAMEDELD IA+GQE+RT+WLNNFYFGG+HGV S+AR Sbjct: 557 VAFAVVGLLEQHFGRLVDYDFTAAMEDELDEIANGQEQRTNWLNNFYFGGEHGVEGSIAR 616 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED--GEPTP 679 AGGLK+LVG NLEGIDAREVNSIK+FDD +GRP+YVRVG+NGPYLER + D GE P Sbjct: 617 AGGLKQLVGGNLEGIDAREVNSIKVFDDSEGRPVYVRVGRNGPYLERMVDDPDNPGEQKP 676 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL--X 737 QRANL + LTPDELT LAE+LFATPQEGR LGIDPE+GHEIVAKDGR+GPYVTE+L Sbjct: 677 QRANLKEDLTPDELTPELAEKLFATPQEGRSLGIDPETGHEIVAKDGRFGPYVTEVLPEP 736 Query: 738 XXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASG 797 R+GSL RSMDL+T+TLEDALKLLSLPRVVG DP + Sbjct: 737 EDGGDDGTAGTPAKKGKKPTGPKPRTGSLFRSMDLETVTLEDALKLLSLPRVVGVDPTTN 796 Query: 798 EEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLREL 857 EEITAQNGRYGPYLKRGTDSRSLATEDQIF+ITLDEALKIYAEPKR GRQ+ASAPPLREL Sbjct: 797 EEITAQNGRYGPYLKRGTDSRSLATEDQIFTITLDEALKIYAEPKRRGRQAASAPPLREL 856 Query: 858 GTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKR- 916 G D SGKPMVIKDGRFGPYVTDGETNASLRKGD+V +ITDERASELLADRRARGPVK+ Sbjct: 857 GNDPVSGKPMVIKDGRFGPYVTDGETNASLRKGDDVLTITDERASELLADRRARGPVKKK 916 Query: 917 -AAKKTTRKSPAKKAVKR 933 AKK +K+PAKKA + Sbjct: 917 APAKKAAKKAPAKKAAAK 934 >tr|Q1B2I4|Q1B2I4_MYCSS Tax_Id=164756 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium sp.] Length = 957 Score = 1420 bits (3676), Expect = 0.0 Identities = 727/914 (79%), Positives = 788/914 (86%), Gaps = 6/914 (0%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG YIVESSRGHIRDLPRAAADVPAK+KSEPWARLGV+V+ DF Sbjct: 35 LVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVDVEHDF 94 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYIISP+KKS V+ ATDGDREGEAIAWHLLETLKPR+PVKRMVFH Sbjct: 95 EPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFH 154 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 155 EITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 214 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAFR+A YWD+ A LDASVSDP+A PPTF A+L SVDG RVATGRDFDS Sbjct: 215 TRIIVQRERERMAFRTAGYWDVSAELDASVSDPQATPPTFTAKLNSVDGRRVATGRDFDS 274 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 LG +RK DEV VLDEA A ALA GL AQLSV+SVE+KPY+RRPY PFMTSTLQQEAGRK Sbjct: 275 LGQVRKPDEVLVLDEAAAGALAAGLQAAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRK 334 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRFS ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYGEEYV + RQYT Sbjct: 335 LRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTARQYT 394 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + +LD DEFRLYELIWQRTVASQMADARGTTLSL Sbjct: 395 RKVKNAQEAHEAIRPAGDVFQTPGQLHAQLDTDEFRLYELIWQRTVASQMADARGTTLSL 454 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G + + Q VVFSASGRT+TF GFLKAYVE++DEL GGE+DDAE RLPNLT GQR+DA Sbjct: 455 RIAGDSRDGQSVVFSASGRTITFAGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDA 514 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 ELTP GH T+PPARYTEASL+KA E+LGIGRPSTY+ IIKTIQDRGYVHKKGSALVPSW Sbjct: 515 KELTPAGHQTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSW 574 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLEQHFG LVDYGFTAAMEDELD IASG ERRT+WL NFYFGG+HGV DS+AR Sbjct: 575 VAFAVIGLLEQHFGRLVDYGFTAAMEDELDEIASGTERRTNWLKNFYFGGEHGVGDSIAR 634 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED--GEPTP 679 AGGLKKLVGVNLE IDAREVNSIKLFDD +GRPIYVRVGKNGPYLER + E+ GE P Sbjct: 635 AGGLKKLVGVNLEEIDAREVNSIKLFDDAEGRPIYVRVGKNGPYLERMVADEENPGELKP 694 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILXXX 739 QRANL D LTPDELTL LAE+LF+TPQEGR LG+DPE+GHEIVAKDGRYGPYVTE+L Sbjct: 695 QRANLKDELTPDELTLELAEKLFSTPQEGRTLGVDPETGHEIVAKDGRYGPYVTEVL-PA 753 Query: 740 XXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEE 799 R+GSLLR+MDL+T+TL+DALKLLSLPRVVG DP +GEE Sbjct: 754 PPEEPEDGAPAKKGKKPTGPKPRTGSLLRTMDLETVTLDDALKLLSLPRVVGVDPNTGEE 813 Query: 800 ITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGT 859 ITAQNGRYGPYLKRGTDSRSLATE+Q+F+ITLDEALKIYAEPKR GRQ A+ PPLRELG Sbjct: 814 ITAQNGRYGPYLKRGTDSRSLATEEQMFTITLDEALKIYAEPKRRGRQGAATPPLRELGV 873 Query: 860 DAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAAK 919 D S KPMVIKDGRFGPYVTDGETNASLRKGD+V SITD RASELLADRRARGPVK+ K Sbjct: 874 DPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKK--K 931 Query: 920 KTTRKSPAKKAVKR 933 +K+PAKK + Sbjct: 932 AAAKKAPAKKTAAK 945 >tr|A3Q719|A3Q719_MYCSJ Tax_Id=164757 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium sp.] Length = 957 Score = 1420 bits (3676), Expect = 0.0 Identities = 727/914 (79%), Positives = 788/914 (86%), Gaps = 6/914 (0%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG YIVESSRGHIRDLPRAAADVPAK+KSEPWARLGV+V+ DF Sbjct: 35 LVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVDVEHDF 94 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYIISP+KKS V+ ATDGDREGEAIAWHLLETLKPR+PVKRMVFH Sbjct: 95 EPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFH 154 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 155 EITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 214 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAFR+A YWD+ A LDASVSDP+A PPTF A+L SVDG RVATGRDFDS Sbjct: 215 TRIIVQRERERMAFRTAGYWDVSAELDASVSDPQATPPTFTAKLNSVDGRRVATGRDFDS 274 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 LG +RK DEV VLDEA A ALA GL AQLSV+SVE+KPY+RRPY PFMTSTLQQEAGRK Sbjct: 275 LGQVRKPDEVLVLDEAAAGALAAGLQAAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRK 334 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRFS ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYGEEYV + RQYT Sbjct: 335 LRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTARQYT 394 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + +LD DEFRLYELIWQRTVASQMADARGTTLSL Sbjct: 395 RKVKNAQEAHEAIRPAGDVFQTPGQLHAQLDTDEFRLYELIWQRTVASQMADARGTTLSL 454 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G + + Q VVFSASGRT+TF GFLKAYVE++DEL GGE+DDAE RLPNLT GQR+DA Sbjct: 455 RIAGDSRDGQSVVFSASGRTITFAGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDA 514 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 ELTP GH T+PPARYTEASL+KA E+LGIGRPSTY+ IIKTIQDRGYVHKKGSALVPSW Sbjct: 515 KELTPAGHQTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSW 574 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLEQHFG LVDYGFTAAMEDELD IASG ERRT+WL NFYFGG+HGV DS+AR Sbjct: 575 VAFAVIGLLEQHFGRLVDYGFTAAMEDELDEIASGTERRTNWLKNFYFGGEHGVGDSIAR 634 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED--GEPTP 679 AGGLKKLVGVNLE IDAREVNSIKLFDD +GRPIYVRVGKNGPYLER + E+ GE P Sbjct: 635 AGGLKKLVGVNLEEIDAREVNSIKLFDDAEGRPIYVRVGKNGPYLERMVADEENPGELKP 694 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILXXX 739 QRANL D LTPDELTL LAE+LF+TPQEGR LG+DPE+GHEIVAKDGRYGPYVTE+L Sbjct: 695 QRANLKDELTPDELTLELAEKLFSTPQEGRTLGVDPETGHEIVAKDGRYGPYVTEVL-PA 753 Query: 740 XXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEE 799 R+GSLLR+MDL+T+TL+DALKLLSLPRVVG DP +GEE Sbjct: 754 PPEEPEDGAPAKKGKKPTGPKPRTGSLLRTMDLETVTLDDALKLLSLPRVVGVDPNTGEE 813 Query: 800 ITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGT 859 ITAQNGRYGPYLKRGTDSRSLATE+Q+F+ITLDEALKIYAEPKR GRQ A+ PPLRELG Sbjct: 814 ITAQNGRYGPYLKRGTDSRSLATEEQMFTITLDEALKIYAEPKRRGRQGAATPPLRELGV 873 Query: 860 DAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAAK 919 D S KPMVIKDGRFGPYVTDGETNASLRKGD+V SITD RASELLADRRARGPVK+ K Sbjct: 874 DPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKK--K 931 Query: 920 KTTRKSPAKKAVKR 933 +K+PAKK + Sbjct: 932 AAAKKAPAKKTAAK 945 >tr|A1UML4|A1UML4_MYCSK Tax_Id=189918 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium sp.] Length = 957 Score = 1420 bits (3676), Expect = 0.0 Identities = 727/914 (79%), Positives = 788/914 (86%), Gaps = 6/914 (0%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG YIVESSRGHIRDLPRAAADVPAK+KSEPWARLGV+V+ DF Sbjct: 35 LVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVDVEHDF 94 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYIISP+KKS V+ ATDGDREGEAIAWHLLETLKPR+PVKRMVFH Sbjct: 95 EPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFH 154 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 155 EITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 214 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAFR+A YWD+ A LDASVSDP+A PPTF A+L SVDG RVATGRDFDS Sbjct: 215 TRIIVQRERERMAFRTAGYWDVSAELDASVSDPQATPPTFTAKLNSVDGRRVATGRDFDS 274 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 LG +RK DEV VLDEA A ALA GL AQLSV+SVE+KPY+RRPY PFMTSTLQQEAGRK Sbjct: 275 LGQVRKPDEVLVLDEAAAGALAAGLQAAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRK 334 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRFS ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYGEEYV + RQYT Sbjct: 335 LRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTARQYT 394 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + +LD DEFRLYELIWQRTVASQMADARGTTLSL Sbjct: 395 RKVKNAQEAHEAIRPAGDVFQTPGQLHAQLDTDEFRLYELIWQRTVASQMADARGTTLSL 454 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G + + Q VVFSASGRT+TF GFLKAYVE++DEL GGE+DDAE RLPNLT GQR+DA Sbjct: 455 RIAGDSRDGQSVVFSASGRTITFAGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDA 514 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 ELTP GH T+PPARYTEASL+KA E+LGIGRPSTY+ IIKTIQDRGYVHKKGSALVPSW Sbjct: 515 KELTPAGHQTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSW 574 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLEQHFG LVDYGFTAAMEDELD IASG ERRT+WL NFYFGG+HGV DS+AR Sbjct: 575 VAFAVIGLLEQHFGRLVDYGFTAAMEDELDEIASGTERRTNWLKNFYFGGEHGVGDSIAR 634 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED--GEPTP 679 AGGLKKLVGVNLE IDAREVNSIKLFDD +GRPIYVRVGKNGPYLER + E+ GE P Sbjct: 635 AGGLKKLVGVNLEEIDAREVNSIKLFDDAEGRPIYVRVGKNGPYLERMVADEENPGELKP 694 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILXXX 739 QRANL D LTPDELTL LAE+LF+TPQEGR LG+DPE+GHEIVAKDGRYGPYVTE+L Sbjct: 695 QRANLKDELTPDELTLELAEKLFSTPQEGRTLGVDPETGHEIVAKDGRYGPYVTEVL-PA 753 Query: 740 XXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEE 799 R+GSLLR+MDL+T+TL+DALKLLSLPRVVG DP +GEE Sbjct: 754 PPEEPEDGAPAKKGKKPTGPKPRTGSLLRTMDLETVTLDDALKLLSLPRVVGVDPNTGEE 813 Query: 800 ITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGT 859 ITAQNGRYGPYLKRGTDSRSLATE+Q+F+ITLDEALKIYAEPKR GRQ A+ PPLRELG Sbjct: 814 ITAQNGRYGPYLKRGTDSRSLATEEQMFTITLDEALKIYAEPKRRGRQGAATPPLRELGV 873 Query: 860 DAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAAK 919 D S KPMVIKDGRFGPYVTDGETNASLRKGD+V SITD RASELLADRRARGPVK+ K Sbjct: 874 DPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKK--K 931 Query: 920 KTTRKSPAKKAVKR 933 +K+PAKK + Sbjct: 932 AAAKKAPAKKTAAK 945 >tr|A1TG67|A1TG67_MYCVP Tax_Id=350058 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium vanbaalenii] Length = 955 Score = 1405 bits (3637), Expect = 0.0 Identities = 725/927 (78%), Positives = 790/927 (85%), Gaps = 16/927 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG YIVESSRGHIRDLPR AADVPAK+KSEPWARLGVNV+ +F Sbjct: 26 LVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRNAADVPAKYKSEPWARLGVNVEHNF 85 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYIISP+KKS V+ ATDGDREGEAIAWHLLETLKPR+PVKRMVFH Sbjct: 86 EPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFH 145 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 146 EITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 205 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAFRSA YWD+ A LDASVSD +A+PPTFVA+L +VDG RVATGRDFDS Sbjct: 206 TRIIVQRERERMAFRSAGYWDVTAELDASVSDAQASPPTFVAKLNTVDGRRVATGRDFDS 265 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 LG +RK DEV VLDEA A ALATGL GAQL+V+SVE+KPY+RRPY PFMTSTLQQEAGRK Sbjct: 266 LGAVRKPDEVLVLDEAAANALATGLRGAQLAVSSVEQKPYTRRPYAPFMTSTLQQEAGRK 325 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRF+ ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYGEEYV +PRQYT Sbjct: 326 LRFTSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYT 385 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + +LD DEFRLYELIWQRTVASQMADARGTTLSL Sbjct: 386 RKVKNAQEAHEAIRPAGDVFQTPGQLHSQLDTDEFRLYELIWQRTVASQMADARGTTLSL 445 Query: 443 RI----------GGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPN 492 RI GG+A + QVVF+ASGRT+TFPGFLKAYVE++D+L GGEADDAE RLPN Sbjct: 446 RIAGAAPATTLGGGTASDVQVVFNASGRTITFPGFLKAYVESIDDLAGGEADDAESRLPN 505 Query: 493 LTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHK 552 LT GQR+DA LT DGHTT+PPARYTEASL+KA E+LGIGRPSTY+ IIKTIQDRGYVHK Sbjct: 506 LTQGQRVDAKGLTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHK 565 Query: 553 KGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGD 612 KGSALVPSWVAFAV GLLEQHFG LVDY FTAAMEDELD IA+G ERRT+WLNNFYFGG+ Sbjct: 566 KGSALVPSWVAFAVIGLLEQHFGRLVDYDFTAAMEDELDEIAAGHERRTNWLNNFYFGGE 625 Query: 613 HGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITG 672 HG S+AR+GGLKKLVG NLE IDAREVNSIKLFDD +GR + VRVG+NG YLER + Sbjct: 626 HGADGSIARSGGLKKLVGGNLEEIDAREVNSIKLFDDAEGRAVNVRVGRNGAYLERMVAD 685 Query: 673 ED--GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGP 730 D GE PQRANL D LTPDELTL LAE+LFATPQEGR LG+DP +GHEIVAKDGRYGP Sbjct: 686 PDNPGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGVDPATGHEIVAKDGRYGP 745 Query: 731 YVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVV 790 YVTE+L R+GSLLRSMDL+T+TLEDAL+LLSLPRVV Sbjct: 746 YVTEVL-PEPPDEGEAGATAKKGKKPTGPKPRTGSLLRSMDLETVTLEDALRLLSLPRVV 804 Query: 791 GTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSAS 850 G DPASGEEITAQNGRYGPYLKRGTDSRSLATE+Q+F ITL+EALKIYAEPKR GRQ A+ Sbjct: 805 GVDPASGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAA 864 Query: 851 APPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRA 910 PPLRELG D S KPMVIKDGRFGPYVTDGETNASLRKGD+V SITD RASELLADRRA Sbjct: 865 TPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDARASELLADRRA 924 Query: 911 RGPVKRAA--KKTTRKSPAKK-AVKRA 934 RGPVK+ A K +K+PAKK A K+A Sbjct: 925 RGPVKKKAVKKAPAKKTPAKKTAAKKA 951 >tr|A4T5R5|A4T5R5_MYCGI Tax_Id=350054 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium gilvum] Length = 941 Score = 1403 bits (3632), Expect = 0.0 Identities = 723/926 (78%), Positives = 786/926 (84%), Gaps = 15/926 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG Y+VESSRGHIRDLPRAAADVPAK+KSEPWARLGVNVDADF Sbjct: 17 LVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADF 76 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYIISP+KK+ V+ ATDGDREGEAIAWHLLETLKPR+PVKRMVFH Sbjct: 77 EPLYIISPDKKATVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFH 136 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+PRDLD DLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA Sbjct: 137 EITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 196 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAFRSA YWD+ A LDASVSD +A PPTFVA+L +VDG RVA GRDFDS Sbjct: 197 TRIIVQRERERMAFRSAGYWDVTAELDASVSDAQATPPTFVAKLNTVDGRRVAAGRDFDS 256 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 LG ++K EV VLDEA A ALA GL GAQLSV+SVE+KPY+RRPY PFMTSTLQQEAGRK Sbjct: 257 LGAVKKPGEVLVLDEAAANALAGGLRGAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRK 316 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LR S ERTMSIAQRLYENGYITYMRTDSTTLS+SAI+AAR QARQLYGEEYV +PRQYT Sbjct: 317 LRMSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYT 376 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + +LD DEFRLYELIWQRTVASQMADARGTTLSL Sbjct: 377 RKVKNAQEAHEAIRPAGDVFQTPGQLHSQLDTDEFRLYELIWQRTVASQMADARGTTLSL 436 Query: 443 RIGGSA-GEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G+A +QVVF+ASGRT+TF GFLKAYVE++DE GGEADDAE RLPNLT GQR+DA Sbjct: 437 RIAGAATSGEQVVFNASGRTITFAGFLKAYVESLDEQAGGEADDAESRLPNLTQGQRVDA 496 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 +LT DGHTT+PPARYTEASL+KA E+LGIGRPSTY+ IIKTIQDRGYVHKKGSALVPSW Sbjct: 497 KDLTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSW 556 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLEQHF LVDY FTAAMEDELD IA+G ERRT+WLNNFYFGG+HGV S+AR Sbjct: 557 VAFAVIGLLEQHFSRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGEHGVEGSIAR 616 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED--GEPTP 679 GGLKKLVG NLE IDAREVNSIKLFDD +GR + VRVG+NG YLER + D GE P Sbjct: 617 EGGLKKLVGGNLEEIDAREVNSIKLFDDSEGRAVNVRVGRNGAYLERMVADPDNPGELKP 676 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILXXX 739 QRANL D LTPDELTL LAE+LFATPQEGR LGIDP +GHEIVAKDGRYGPYVTE+L Sbjct: 677 QRANLKDELTPDELTLELAEKLFATPQEGRSLGIDPATGHEIVAKDGRYGPYVTEVL-PE 735 Query: 740 XXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEE 799 R+GSLLRSMDL+T+TL+DAL+LLSLPRVVG DPA+GEE Sbjct: 736 PPDDGEAGATAKKGKKPTGPKPRTGSLLRSMDLETVTLDDALRLLSLPRVVGVDPANGEE 795 Query: 800 ITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGT 859 ITAQNGRYGPYLKRGTDSRSLATE+Q+F ITL+EALKIYAEPKR GRQ A+ PPLRELG Sbjct: 796 ITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGV 855 Query: 860 DAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKR--- 916 D S KPMVIKDGRFGPYVTDGETNASLRKGD+V SITD RASELLADRRARGPVK+ Sbjct: 856 DPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKKKAA 915 Query: 917 --------AAKKTTRKSPAKKAVKRA 934 AAKK +K+PAKKA K+A Sbjct: 916 KKAAVKKTAAKKAAKKAPAKKAAKKA 941 >tr|B1MGQ4|B1MGQ4_MYCA9 Tax_Id=561007 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Mycobacterium abscessus] Length = 930 Score = 1374 bits (3557), Expect = 0.0 Identities = 706/918 (76%), Positives = 772/918 (84%), Gaps = 11/918 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG Y+VESSRGHIRDLPRAAADVPAK+KSEPWARLGVNVDADF Sbjct: 4 LVIVESPTKARKIAGYLGDGYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADF 63 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYI+SP+KK V+ ATDGDREGEAIAWHLLETLKP+VPV+RMVFH Sbjct: 64 EPLYIVSPDKKGTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPKVPVRRMVFH 123 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITE AIL AA++PRDLD +LVDAQETRRILDRLYGYEVSPVLWKKV LSAGRVQSVA Sbjct: 124 EITEQAILAAAQDPRDLDNNLVDAQETRRILDRLYGYEVSPVLWKKVGRNLSAGRVQSVA 183 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRERDRMAFRSA YWD+ A LDA +P A PP F ARL SVD LRVA+GRDFDS Sbjct: 184 TRIIVQRERDRMAFRSAGYWDLGAELDAGKDNPAAKPPRFHARLVSVDALRVASGRDFDS 243 Query: 263 LGTLRKADE---VTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEA 319 LG +++ V VLDE RA AL GL A L+V S EEKPY+R+PYPPFMTSTLQQEA Sbjct: 244 LGQVKETSNGPGVLVLDETRANALVAGLSQATLTVVSAEEKPYTRKPYPPFMTSTLQQEA 303 Query: 320 GRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPR 379 GRKLRFS ERTMSIAQRLYENGYITYMRTDSTTLS+SA+ AAR+QA +LYG EYV SPR Sbjct: 304 GRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSDSALQAARSQAAELYGNEYVHPSPR 363 Query: 380 QYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTT 439 QYTRKVKNAQEAHEAIRPAGETF TP + LD DEFRLYELIWQRTVASQMADARGTT Sbjct: 364 QYTRKVKNAQEAHEAIRPAGETFKTPGQLHSSLDNDEFRLYELIWQRTVASQMADARGTT 423 Query: 440 LSLRIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQR 498 LSLR+ G+A +QVVF+ASGRT+TFPGFL AYVETVDEL GGEADD ERRLP L GQ Sbjct: 424 LSLRLAGTATSGEQVVFTASGRTITFPGFLSAYVETVDELSGGEADDEERRLPQLRQGQS 483 Query: 499 LDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALV 558 + EL+ DGHTTNPPARYTEASL+KA EELGIGRPSTY+ II+TIQDRGYVHK+GSALV Sbjct: 484 VTVAELSADGHTTNPPARYTEASLIKALEELGIGRPSTYSSIIRTIQDRGYVHKRGSALV 543 Query: 559 PSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDS 618 PSW AFAV GLLEQHFG LVDY FTAAMED+LD IASG ERRT+WLN FYFGGDHGV S Sbjct: 544 PSWTAFAVIGLLEQHFGRLVDYDFTAAMEDDLDEIASGNERRTNWLNAFYFGGDHGVEGS 603 Query: 619 VARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEP- 677 VARAGGLK+LVGVNLE IDARE+NSIKLFDD+QGRPIYVRVGKNGPYLER + DGE Sbjct: 604 VARAGGLKRLVGVNLEEIDAREINSIKLFDDDQGRPIYVRVGKNGPYLERMVADPDGEAG 663 Query: 678 --TPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEI 735 PQRAN+ D +TPDELT+ +AE+LFA PQEGR LG+DPE+GHEIVAKDGR+GPYVTE+ Sbjct: 664 ALIPQRANVKDGVTPDELTVEMAEQLFAIPQEGRTLGVDPETGHEIVAKDGRFGPYVTEV 723 Query: 736 LXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPA 795 L R+GSLL+SM L+T+TLEDAL+LLSLPRVVG DPA Sbjct: 724 L-PAPPEPVEAEKPKRGAKKVEGPKPRTGSLLKSMTLETVTLEDALRLLSLPRVVGVDPA 782 Query: 796 SGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLR 855 SGEEITAQNGRYGPYLKRGTDSRSLATE QIF++TLDEALKIY+EPKR G Q+ASA PLR Sbjct: 783 SGEEITAQNGRYGPYLKRGTDSRSLATEGQIFTVTLDEALKIYSEPKRRGGQAASAAPLR 842 Query: 856 ELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVK 915 ELG D+A+GKPMVIKDGRFGPYVTDGETNASLRKGD+V SITDERASELLADRRARGPVK Sbjct: 843 ELGVDSATGKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDERASELLADRRARGPVK 902 Query: 916 RAAK---KTTRKSPAKKA 930 RA K K +K+PAKKA Sbjct: 903 RAKKAPAKAAKKAPAKKA 920 >tr|Q5Z2Y2|Q5Z2Y2_NOCFA Tax_Id=37329 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Nocardia farcinica] Length = 976 Score = 1306 bits (3380), Expect = 0.0 Identities = 677/913 (74%), Positives = 751/913 (82%), Gaps = 10/913 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+A YLG Y VE+S GHIRDLPR AADVPAK+K +PWARLGV+VD DF Sbjct: 22 LVIVESPTKARKIAPYLGRNYTVEASVGHIRDLPRGAADVPAKYKGQPWARLGVDVDNDF 81 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EP+Y++SP+KK+ V+ ATD DREGEAIAWHLLETLKP+VPV+RMVFH Sbjct: 82 EPIYVVSPDKKAKVTELKSLLADADELYLATDPDREGEAIAWHLLETLKPKVPVRRMVFH 141 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AA + R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 142 EITEPAIRAAAADTRELDPDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 201 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAA--PPTFVARLTSVDGLRVATGRDF 260 TR+IVQRER+RMAFRSA YWDI A LDA + A P TF ARL +VDG RVA+GRDF Sbjct: 202 TRVIVQRERERMAFRSAEYWDIAAKLDAGADEQSDAANPRTFGARLVNVDGARVASGRDF 261 Query: 261 DSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAG 320 G L+ A V VLDEARA LA L G L+V S E KPYSR+PYPPFMTSTLQQEAG Sbjct: 262 GPDGQLKSASGVVVLDEARARRLAEALDGVDLAVTSAESKPYSRKPYPPFMTSTLQQEAG 321 Query: 321 RKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQ 380 RKLRF+ ERTM +AQRLYENGYITYMRTDSTTLSESAI AAR+QA QLYG EYV SPRQ Sbjct: 322 RKLRFTSERTMRVAQRLYENGYITYMRTDSTTLSESAIAAARSQATQLYGAEYVHPSPRQ 381 Query: 381 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTL 440 Y RKVKNAQEAHEAIRPAG+TFATP + LD DEFRLYELIWQRTVASQMADARGTTL Sbjct: 382 YNRKVKNAQEAHEAIRPAGDTFATPGQLHSRLDNDEFRLYELIWQRTVASQMADARGTTL 441 Query: 441 SLRIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRL 499 +LRI G AG ++ VFSASGRT+TFPGFLKAYVE+VDE GG++DDAE RLP L GQ + Sbjct: 442 TLRITGVAGTGEECVFSASGRTITFPGFLKAYVESVDEEAGGQSDDAESRLPALEEGQNV 501 Query: 500 DAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVP 559 AVEL PDGH+TNPPARYTEASL+KA EELGIGRPSTY+ IIKTI DRGYV+K+GSALVP Sbjct: 502 TAVELNPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKTILDRGYVYKRGSALVP 561 Query: 560 SWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSV 619 SWVAFAV GLLE +FG LVD+ FTAAMED+LDAIASG+ERR +WL++FYFGGD GV SV Sbjct: 562 SWVAFAVVGLLEAYFGRLVDFDFTAAMEDDLDAIASGRERRGNWLSSFYFGGDSGVEGSV 621 Query: 620 ARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTIT---GEDGE 676 AR+GGLKK+VG L+ IDAREVNSIKLF D +GR + VRVG+ GPYLER +T DG+ Sbjct: 622 ARSGGLKKMVGEQLDDIDAREVNSIKLFTDAEGRDVVVRVGRYGPYLERLVTDPDDPDGD 681 Query: 677 PTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL 736 P QRANL D L PDELT +AE+LFATPQEGR LG+DP +GHEIVAK+GR+GPYVTEIL Sbjct: 682 PISQRANLPDDLPPDELTPEVAEKLFATPQEGRSLGVDPATGHEIVAKEGRFGPYVTEIL 741 Query: 737 XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPAS 796 R+GSL +SMDL +ITL+DALKLLSLPRVVGTDPA+ Sbjct: 742 ----PEPATEEGAKKTAAKKTAPKPRTGSLFKSMDLASITLDDALKLLSLPRVVGTDPAT 797 Query: 797 GEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRE 856 GEEITAQNGRYGPYLK+GTDSRSLA+EDQIF+ITLDEALKIYAEPKR G QSASA PLRE Sbjct: 798 GEEITAQNGRYGPYLKKGTDSRSLASEDQIFTITLDEALKIYAEPKRRGGQSASAAPLRE 857 Query: 857 LGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKR 916 LGTD SGKPMVIKDGRFGPYVTDGETNASLRKGDEV SITDERA+ELLADRRARGPVK+ Sbjct: 858 LGTDPVSGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDERAAELLADRRARGPVKK 917 Query: 917 AAKKTTRKSPAKK 929 AKK +K+ AKK Sbjct: 918 TAKKAAKKTAAKK 930 >tr|C1BA07|C1BA07_RHOOB Tax_Id=632772 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Rhodococcus opacus] Length = 973 Score = 1278 bits (3307), Expect = 0.0 Identities = 669/937 (71%), Positives = 746/937 (79%), Gaps = 32/937 (3%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+A YLG Y+VE+S GHIRDLPR AADVPAK+K E WARLGVNVD DF Sbjct: 22 LVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDQDF 81 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY++SPEKKS V+ ATD DREGEAIAWHLLETLKP++PV+RMVFH Sbjct: 82 EPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFH 141 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+ R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 142 EITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 201 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAFRSASYWDI ATLDA A+P +F ARL SVDG RVATGRDF S Sbjct: 202 TRVIVQRERERMAFRSASYWDISATLDAGAD---ASPRSFGARLVSVDGSRVATGRDFGS 258 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K VTVLDEARA LA L G L+V+S E KPY+R+PY PFMTSTLQQEAGRK Sbjct: 259 DGQL-KTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTSTLQQEAGRK 317 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRF+ ERTM IAQRLYENGYITYMRTDSTTLS SAI AAR QA +LYG EYV +PRQYT Sbjct: 318 LRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEYVHDTPRQYT 377 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + LD DEFRLYELIWQRTVASQMADARGTTL+L Sbjct: 378 RKVKNAQEAHEAIRPAGDVFQTPGQLHSRLDTDEFRLYELIWQRTVASQMADARGTTLTL 437 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G+AG ++ FS+SGRT+TF GFLKAYVE+VDE GG++DDAE RLP L GQ + A Sbjct: 438 RITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESRLPVLVEGQAVTA 497 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 +L PDGHTTNPPARYTEASL+K EELGIGRPSTY+ IIKTI DRGYV+K+GSALVPSW Sbjct: 498 TKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSW 557 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLE HFG LVD+ FTA MED+LDAIA G+E+R +WL++FYFGGDHG SVAR Sbjct: 558 VAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGDHGAEGSVAR 617 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED---GEPT 678 GGLKK+VGVNLE IDAREVNSI+LFDD +GR ++VRVG+ GPYLER + D G+ Sbjct: 618 EGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLI 677 Query: 679 PQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL-- 736 QRANL D L PDELT AE+LF+TPQEGR LG+DP +GHEIVAK+GR+GPYVTEIL Sbjct: 678 SQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPE 737 Query: 737 --------------------XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT 776 R+GSLL+SMDL T+T Sbjct: 738 PEPEPEPAVVPVTDESGDGTTKTKTAAAKKAPAKKAAKKATGPKPRTGSLLKSMDLATVT 797 Query: 777 LEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALK 836 L+DALKLLSLPRVVG DP S EEITAQNGRYGPYLK+GTDSRSLATEDQ+F++TLDEALK Sbjct: 798 LDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEDQMFTVTLDEALK 857 Query: 837 IYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASI 896 IYAEPKR GRQ+A+ PPLRELG D+ S KPMVIKDGRFGPYVTDGETNASLRKGDEV SI Sbjct: 858 IYAEPKRRGRQAAATPPLRELGVDSVSEKPMVIKDGRFGPYVTDGETNASLRKGDEVESI 917 Query: 897 TDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 TD RASELLADRRARGPVK+ K +K+PAKKA K+ Sbjct: 918 TDARASELLADRRARGPVKK--KAAAKKAPAKKAAKK 952 >tr|Q0S8J3|Q0S8J3_RHOSR Tax_Id=101510 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Rhodococcus sp.] Length = 973 Score = 1276 bits (3302), Expect = 0.0 Identities = 668/937 (71%), Positives = 745/937 (79%), Gaps = 32/937 (3%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+A YLG Y+VE+S GHIRDLPR AADVPAK+K E WARLGVNVD DF Sbjct: 22 LVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDHDF 81 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY++SPEKKS V+ ATD DREGEAIAWHLLETLKP++PV+RMVFH Sbjct: 82 EPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFH 141 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+ R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 142 EITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 201 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAFRSASYWDI ATLDA A+P +F ARL SVDG RVATGRDF + Sbjct: 202 TRVIVQRERERMAFRSASYWDISATLDAGAD---ASPRSFGARLVSVDGSRVATGRDFGA 258 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K VTVLDEARA LA L G L+V+S E KPY+R+PY PFMTSTLQQEAGRK Sbjct: 259 DGQL-KTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTSTLQQEAGRK 317 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRF+ ERTM IAQRLYENGYITYMRTDSTTLS SAI AAR QA +LYG EYV +PRQYT Sbjct: 318 LRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEYVHDTPRQYT 377 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + LD DEFRLYELIWQRTVASQMADARGTTL+L Sbjct: 378 RKVKNAQEAHEAIRPAGDVFQTPGQLHSRLDTDEFRLYELIWQRTVASQMADARGTTLTL 437 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G+AG ++ FS+SGRT+TF GFLKAYVE+VDE GG++DDAE RLP L GQ + A Sbjct: 438 RITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESRLPVLVEGQAVTA 497 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 +L PDGHTTNPPARYTEASL+K EELGIGRPSTY+ IIKTI DRGYV+K+GSALVPSW Sbjct: 498 TKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSW 557 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLE HFG LVD+ FTA MED+LDAIA G+E+R +WL++FYFGGDHG SVAR Sbjct: 558 VAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGDHGAEGSVAR 617 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED---GEPT 678 GGLKK+VGVNLE IDAREVNSI+LFDD +GR ++VRVG+ GPYLER + D G+ Sbjct: 618 EGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLI 677 Query: 679 PQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL-- 736 QRANL D L PDELT AE+LF+TPQEGR LG+DP +GHEIVAK+GR+GPYVTEIL Sbjct: 678 SQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPE 737 Query: 737 --------------------XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT 776 R+GSLL+SMDL T+T Sbjct: 738 PEPEPEPAVVPVTDESGDGTTKTKTAAKKAPAKKAAAKKATGPKPRTGSLLKSMDLATVT 797 Query: 777 LEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALK 836 L+DALKLLSLPRVVG DP S EEITAQNGRYGPYLK+GTDSRSLATEDQ+F++TLDEALK Sbjct: 798 LDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEDQMFTVTLDEALK 857 Query: 837 IYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASI 896 IYAEPKR GRQ+A+ PPLRELG D S KPMVIKDGRFGPYVTDGETNASLRKGDEV SI Sbjct: 858 IYAEPKRRGRQAAATPPLRELGVDTVSEKPMVIKDGRFGPYVTDGETNASLRKGDEVESI 917 Query: 897 TDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 TD RASELLADRRARGPVK+ K +K+PAKKA K+ Sbjct: 918 TDARASELLADRRARGPVKK--KAAAKKAPAKKAAKK 952 >tr|C0ZNG9|C0ZNG9_RHOE4 Tax_Id=234621 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Rhodococcus erythropolis] Length = 978 Score = 1252 bits (3239), Expect = 0.0 Identities = 656/943 (69%), Positives = 741/943 (78%), Gaps = 38/943 (4%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+A YLG Y+VE+S GHIRDLPR AADVPAK+K E WARLGVNVD DF Sbjct: 19 LVIVESPTKARKIAPYLGKDYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDHDF 78 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY++SPEKK V+ ATD DREGEAIAWHLLETLKP++PV+RMVFH Sbjct: 79 EPLYVVSPEKKGKVAELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFH 138 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+ R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 139 EITEPAIRAAAEDTRELDTDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 198 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAF+SASYWDI ATLDA +A+P +F ARL SVDG RVA+GRDF + Sbjct: 199 TRVIVQRERERMAFKSASYWDISATLDAGA---EASPRSFGARLVSVDGSRVASGRDFGA 255 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K VTVLDEA A LA L G L+V+S E+KPY+R+PYPPFMTSTLQQEAGRK Sbjct: 256 DGKL-KGSAVTVLDEAYARRLAEALQGVDLTVSSAEDKPYTRKPYPPFMTSTLQQEAGRK 314 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRF+ ER M IAQRLYENGYITYMRTDSTTLSESAI AAR QA +LYG EYV +PRQYT Sbjct: 315 LRFTSERAMRIAQRLYENGYITYMRTDSTTLSESAIAAARAQATELYGPEYVHPTPRQYT 374 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + +LD DEF+LYELIWQRTVASQMADARGTTL+L Sbjct: 375 RKVKNAQEAHEAIRPAGDVFQTPGQLHSKLDSDEFKLYELIWQRTVASQMADARGTTLTL 434 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G+AG + FSASGRT+ F GFLKAYVE+VDE GG++DDAE RLP L GQ + A Sbjct: 435 RISGTAGTGEDCTFSASGRTIVFAGFLKAYVESVDEEAGGQSDDAESRLPVLVKGQEVTA 494 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 +L PDGH+TNPPARYTEASL+K EELGIGRPSTY+ IIKTI DRGYV+K+GSALVPSW Sbjct: 495 TKLDPDGHSTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSW 554 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLE HFG LVD+ FTA MED+LDAIA G+E+R +WL++FYFGG+ G SVAR Sbjct: 555 VAFAVIGLLEVHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGETGAEGSVAR 614 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED---GEPT 678 GGLKK+VGVNLE IDAREVNSI+LFDD +GR ++VRVG+ GPYLER + D G+ Sbjct: 615 EGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLI 674 Query: 679 PQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL-- 736 QRANL D L PDELT AE+LF+TPQEGR LG+DP +GHEIVAK+GR+GPYVTEIL Sbjct: 675 SQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPE 734 Query: 737 --------------------------XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSM 770 R+GSLL+SM Sbjct: 735 PPAEPEPDIVPVSAPEPEEISSGSTKTAVKKAAAKKAPAKKAAKKVAGPKPRTGSLLKSM 794 Query: 771 DLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSIT 830 DL TITLEDAL+LLSLPRVVG DP S EEITAQNGRYGPYLK+GTDSRSLA E+Q+F++T Sbjct: 795 DLATITLEDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLANEEQMFTVT 854 Query: 831 LDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKG 890 LDEALKIYAEPKR GRQ+++ PPLRELG D S KPMVIKDGRFGPYVTDGETNASLRK Sbjct: 855 LDEALKIYAEPKRRGRQASATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKD 914 Query: 891 DEVASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 D+V SI+D RASELLADRRARGPVK+ K +K+PAKKA + Sbjct: 915 DDVESISDARASELLADRRARGPVKK--KAAAKKAPAKKAAAK 955 Score = 77.0 bits (188), Expect = 1e-11 Identities = 58/202 (28%), Positives = 92/202 (45%), Gaps = 41/202 (20%) Query: 677 PTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL 736 P P+ +L S+ +TL A L + P RV+G+DPES EI A++GRYGPY+ + Sbjct: 783 PKPRTGSLLKSMDLATITLEDALRLLSLP---RVVGVDPESKEEITAQNGRYGPYLKK-- 837 Query: 737 XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLP--------- 787 S SL + T+TL++ALK+ + P Sbjct: 838 -----------------------GTDSRSLANEEQMFTVTLDEALKIYAEPKRRGRQASA 874 Query: 788 ----RVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKR 843 R +G DP S + + ++GR+GPY+ G + SL +D + SI+ A ++ A+ + Sbjct: 875 TPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKDDDVESISDARASELLADRRA 934 Query: 844 SGRQSASAPPLRELGTDAASGK 865 G A + AA+ K Sbjct: 935 RGPVKKKAAAKKAPAKKAAAKK 956 >tr|C3JWG9|C3JWG9_RHOER Tax_Id=596309 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Rhodococcus erythropolis SK121] Length = 978 Score = 1252 bits (3239), Expect = 0.0 Identities = 656/943 (69%), Positives = 741/943 (78%), Gaps = 38/943 (4%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+A YLG Y+VE+S GHIRDLPR AADVPAK+K E WARLGVNVD DF Sbjct: 19 LVIVESPTKARKIAPYLGKDYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDHDF 78 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY++SPEKK V+ ATD DREGEAIAWHLLETLKP++PV+RMVFH Sbjct: 79 EPLYVVSPEKKGKVAELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFH 138 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAE+ R+LD DLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 139 EITEPAIRAAAEDTRELDTDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 198 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IVQRER+RMAF+SASYWDI ATLDA +A+P +F ARL SVDG RVA+GRDF + Sbjct: 199 TRVIVQRERERMAFKSASYWDISATLDAGA---EASPRSFGARLVSVDGSRVASGRDFGA 255 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K VTVLDEA A LA L G L+V+S E+KPY+R+PYPPFMTSTLQQEAGRK Sbjct: 256 DGKL-KGSAVTVLDEAYARRLAEALQGVDLTVSSAEDKPYTRKPYPPFMTSTLQQEAGRK 314 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRF+ ER M IAQRLYENGYITYMRTDSTTLSESAI AAR QA +LYG EYV +PRQYT Sbjct: 315 LRFTSERAMRIAQRLYENGYITYMRTDSTTLSESAIAAARAQATELYGPEYVHPTPRQYT 374 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAG+ F TP + +LD DEF+LYELIWQRTVASQMADARGTTL+L Sbjct: 375 RKVKNAQEAHEAIRPAGDVFQTPGQLHSKLDSDEFKLYELIWQRTVASQMADARGTTLTL 434 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G+AG + FSASGRT+ F GFLKAYVE+VDE GG++DDAE RLP L GQ + A Sbjct: 435 RISGTAGTGEDCTFSASGRTIVFAGFLKAYVESVDEEAGGQSDDAESRLPVLVKGQEVTA 494 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 +L PDGH+TNPPARYTEASL+K EELGIGRPSTY+ IIKTI DRGYV+K+GSALVPSW Sbjct: 495 TKLDPDGHSTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSW 554 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLE HFG LVD+ FTA MED+LDAIA G+E+R +WL++FYFGG+ G SVAR Sbjct: 555 VAFAVIGLLEVHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGETGAEGSVAR 614 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED---GEPT 678 GGLKK+VGVNLE IDAREVNSI+LFDD +GR ++VRVG+ GPYLER + D G+ Sbjct: 615 EGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLI 674 Query: 679 PQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL-- 736 QRANL D L PDELT AE+LF+TPQEGR LG+DP +GHEIVAK+GR+GPYVTEIL Sbjct: 675 SQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPE 734 Query: 737 --------------------------XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSM 770 R+GSLL+SM Sbjct: 735 PPAEPEPDIVPVTAPEPEEISSGSTKTAVKKAAAKKAPAKKAAKKVAGPKPRTGSLLKSM 794 Query: 771 DLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSIT 830 DL TITLEDAL+LLSLPRVVG DP S EEITAQNGRYGPYLK+GTDSRSLA E+Q+F++T Sbjct: 795 DLATITLEDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLANEEQMFTVT 854 Query: 831 LDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKG 890 LDEALKIYAEPKR GRQ+++ PPLRELG D S KPMVIKDGRFGPYVTDGETNASLRK Sbjct: 855 LDEALKIYAEPKRRGRQASATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKD 914 Query: 891 DEVASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 D+V SI+D RASELLADRRARGPVK+ K +K+PAKKA + Sbjct: 915 DDVESISDARASELLADRRARGPVKK--KAAAKKAPAKKAAAK 955 Score = 77.0 bits (188), Expect = 1e-11 Identities = 58/202 (28%), Positives = 92/202 (45%), Gaps = 41/202 (20%) Query: 677 PTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL 736 P P+ +L S+ +TL A L + P RV+G+DPES EI A++GRYGPY+ + Sbjct: 783 PKPRTGSLLKSMDLATITLEDALRLLSLP---RVVGVDPESKEEITAQNGRYGPYLKK-- 837 Query: 737 XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLP--------- 787 S SL + T+TL++ALK+ + P Sbjct: 838 -----------------------GTDSRSLANEEQMFTVTLDEALKIYAEPKRRGRQASA 874 Query: 788 ----RVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKR 843 R +G DP S + + ++GR+GPY+ G + SL +D + SI+ A ++ A+ + Sbjct: 875 TPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKDDDVESISDARASELLADRRA 934 Query: 844 SGRQSASAPPLRELGTDAASGK 865 G A + AA+ K Sbjct: 935 RGPVKKKAAAKKAPAKKAAAKK 956 >tr|C6WFC8|C6WFC8_ACTMD Tax_Id=446462 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Actinosynnema mirum] Length = 923 Score = 1228 bits (3176), Expect = 0.0 Identities = 628/913 (68%), Positives = 722/913 (79%), Gaps = 24/913 (2%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+A YLG ++VESS+GHIRDLPR AADVPAK+K +PWARLGV+VD DF Sbjct: 21 LVIVESPTKARKIASYLGNGFVVESSKGHIRDLPRGAADVPAKYKGQPWARLGVDVDHDF 80 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYI++P+KKS V+ ATDGDREGEAIAWHLLETLKP VPV+RMVFH Sbjct: 81 EPLYIVTPDKKSTVAELKELLKGVDELYLATDGDREGEAIAWHLLETLKPSVPVRRMVFH 140 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAIL AA +PRDLD+ LVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 141 EITEPAILAAAASPRDLDLSLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 200 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR++V+RER+RM F +AS+WD+ AT+DA +A P F RL SVDG R+ATGRDF S Sbjct: 201 TRIVVERERERMKFVTASFWDVSATIDAGA---EATPRQFAGRLVSVDGTRLATGRDFGS 257 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L+ EV VLDEA A A+A GL GA + VASVEEKPY+R+PYPPFMTST+QQEAGRK Sbjct: 258 DGRLKDGVEVKVLDEAHARAIAEGLTGAAMRVASVEEKPYTRKPYPPFMTSTIQQEAGRK 317 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRFS +RTM AQ+LYENGYITYMRTDST LSE+AI AAR QA LYG +YVA PRQYT Sbjct: 318 LRFSADRTMRAAQKLYENGYITYMRTDSTALSETAITAARAQATDLYGAQYVAKEPRQYT 377 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAGE F TP V RELD DE++LYELIWQRT+ASQMADARG T S+ Sbjct: 378 RKVKNAQEAHEAIRPAGEVFRTPGQVARELDSDEYKLYELIWQRTIASQMADARGNTTSV 437 Query: 443 RIGG-SAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 R+ G + G + V+F++SGRT+TF GFLKAYVETVD GG ADDAE RLP L Q + A Sbjct: 438 RVAGRTGGGEDVLFASSGRTITFAGFLKAYVETVDSEAGGNADDAESRLPQLVAEQPVSA 497 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 EL+ DGH+T+PP R+TE SL+K E+LGIGRPSTY II TIQDRGYV KKGSALVPSW Sbjct: 498 AELSADGHSTSPPPRFTEPSLIKTMEDLGIGRPSTYASIISTIQDRGYVWKKGSALVPSW 557 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLEQHFG LVDY FTAA+EDELD IA G++ RT WL+ FYFGGD G S+ R Sbjct: 558 VAFAVVGLLEQHFGRLVDYDFTAALEDELDGIAEGRQERTTWLSGFYFGGDVGPESSIGR 617 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTPQR 681 +GGLKKLVG ++E IDARE+NSI LF DE G + VRVG+ GPYLER + G QR Sbjct: 618 SGGLKKLVGSSVEEIDAREINSIPLFSDEGGHTVVVRVGRYGPYLEREVDG-----ASQR 672 Query: 682 ANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILXXXXX 741 ANL D L PDEL+L +AE+LFATPQEGR LG DP +GHEIVAK+GR+GPYVTE+L Sbjct: 673 ANLPDDLPPDELSLEIAEKLFATPQEGRSLGNDPATGHEIVAKEGRFGPYVTEVL----- 727 Query: 742 XXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEIT 801 R+ SL +SM L T+TLEDAL+LLSLPRVVG DP SG EIT Sbjct: 728 --------PEPAEGKKAGKPRTSSLFKSMSLDTVTLEDALRLLSLPRVVGADPESGAEIT 779 Query: 802 AQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDA 861 AQNGRYGPYLKRGTDSRSL +EDQ+F++TLDEALKIYAEPK+ GR +A+APPL+ELG D Sbjct: 780 AQNGRYGPYLKRGTDSRSLTSEDQLFTVTLDEALKIYAEPKKRGR-AAAAPPLKELGNDP 838 Query: 862 ASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGP-VKRAAKK 920 SGKPMV+K+GRFGPYVTDGETNASLRK D V +++DER SELLA++RA+GP K+ Sbjct: 839 VSGKPMVVKEGRFGPYVTDGETNASLRKSDNVETLSDERGSELLAEKRAKGPSTKKKPAA 898 Query: 921 TTRKSPAKKAVKR 933 T K+ AK A K+ Sbjct: 899 RTTKAAAKPAAKK 911 >tr|C7MQK9|C7MQK9_SACVD Tax_Id=471857 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Saccharomonospora viridis] Length = 921 Score = 1217 bits (3148), Expect = 0.0 Identities = 625/911 (68%), Positives = 724/911 (79%), Gaps = 15/911 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+A YLG Y+VESSRGH+RDLPR AADVPAK+K + WARLGV+VD DF Sbjct: 20 LVIVESPTKARKIAPYLGSDYVVESSRGHVRDLPRGAADVPAKYKGQAWARLGVDVDNDF 79 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLYII+P+KK+ VS ATD DREGEAIAWHLLE LKP+VPV+RMVFH Sbjct: 80 EPLYIITPDKKATVSELKSLLKDVDELYLATDPDREGEAIAWHLLEALKPKVPVRRMVFH 139 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 E+TE AI AAEN RDLD++LVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 140 EVTEQAIRAAAENTRDLDLNLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 199 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RM F SASYWDI A +D +DP+A P +F ARLT VDG R+ATGRDF Sbjct: 200 TRIIVERERERMRFTSASYWDIAAVMDVGDADPEATPRSFPARLTMVDGARLATGRDFGP 259 Query: 263 LGTLR-KADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGR 321 G L+ ++ +V VLDEA A LA L + +V SVEEKPY+RRPY PFMTSTLQQEAGR Sbjct: 260 DGRLKEQSQDVRVLDEAEANRLAEALADREFTVVSVEEKPYTRRPYAPFMTSTLQQEAGR 319 Query: 322 KLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQY 381 KLRFS ERTM +AQRLYENGYITYMRTDSTTLSESA+ AAR+QA +LYG EYVA PRQY Sbjct: 320 KLRFSSERTMRVAQRLYENGYITYMRTDSTTLSESALAAARSQATELYGAEYVADKPRQY 379 Query: 382 TRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLS 441 TRKVKNAQEAHEAIRPAGE F TP AV EL+ DEF+LYELIWQRT+ASQMADA+GTT+S Sbjct: 380 TRKVKNAQEAHEAIRPAGEVFRTPGAVAGELESDEFQLYELIWQRTIASQMADAKGTTMS 439 Query: 442 LRIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLD 500 ++I G+A ++ VFSASGRT+TFPGFLKAYVE+VD GGEADD + RLP L Q L Sbjct: 440 VKIAGTAASGEECVFSASGRTITFPGFLKAYVESVDTEAGGEADDKQSRLPRLVKDQSLT 499 Query: 501 AVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPS 560 A EL PD H T+PP+RY+E SLV EELGIGRPSTY IIKTIQDRGYV KKGSALVPS Sbjct: 500 ATELRPDSHATSPPSRYSEPSLVSKLEELGIGRPSTYASIIKTIQDRGYVWKKGSALVPS 559 Query: 561 WVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG-GDHGVSDSV 619 WVAF+V GL+E+HF LVDY FTAAMEDELD IA+G+E RT+WL+ FYFG G S S+ Sbjct: 560 WVAFSVVGLMERHFERLVDYYFTAAMEDELDRIAAGEEERTEWLSRFYFGNGKDDDSSSI 619 Query: 620 ARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTP 679 GGLKKLVG +E IDARE+NSI +F D +GR +YVRVG+ GPYLER + G+ Sbjct: 620 GSLGGLKKLVGSGVEDIDAREINSIPMFRDNEGRQVYVRVGRYGPYLEREVDGQS----- 674 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILXXX 739 QRANL + L PDELT+ +AE+LFATPQEGRVLG DPE+GHEIV K+GR+GPYVTE+L Sbjct: 675 QRANLPEDLPPDELTVEVAEKLFATPQEGRVLGTDPETGHEIVVKEGRFGPYVTEVL--- 731 Query: 740 XXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEE 799 R+ SL +SM ++ +TL+DALKLLSLPRVVGTDP +GEE Sbjct: 732 --PEPEESADGKKTGKAKKPKPRTASLFKSMSVEDVTLDDALKLLSLPRVVGTDPETGEE 789 Query: 800 ITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGT 859 ITAQNGRYGPYLK+G+DSRSL++E+QIF ITL+EALKIYAEPKR GRQ+A+ PPL+ELG Sbjct: 790 ITAQNGRYGPYLKKGSDSRSLSSEEQIFEITLEEALKIYAEPKRRGRQAAAKPPLKELGE 849 Query: 860 DAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKR--A 917 D SGKP+V+KDGRFGPYVTDGE NASLRK D V +T ERA+ELLA++RA+GP K+ A Sbjct: 850 DPVSGKPIVVKDGRFGPYVTDGEYNASLRKSDTVEDLTPERAAELLAEKRAKGPAKKGTA 909 Query: 918 AKKTTRKSPAK 928 KKT + +K Sbjct: 910 RKKTAAAAKSK 920 >tr|A4F6Q1|A4F6Q1_SACEN Tax_Id=405948 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Saccharopolyspora erythraea] Length = 922 Score = 1207 bits (3123), Expect = 0.0 Identities = 621/918 (67%), Positives = 728/918 (79%), Gaps = 36/918 (3%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 +VIVESP KARK+A YLG ++VESSRGHIRDLP AADVPAK+K +PWARLGV+VD DF Sbjct: 1 MVIVESPAKARKIASYLGSNFVVESSRGHIRDLPSGAADVPAKYKGQPWARLGVDVDNDF 60 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY+++P+KK+ V+ ATDGDREGEAIAWHL+ETLKP+VPV+RMVFH Sbjct: 61 EPLYLVTPDKKATVTELKDALKEVDELYLATDGDREGEAIAWHLMETLKPKVPVRRMVFH 120 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITE AI AA NPR+LD DLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 121 EITESAIQSAAANPRELDRDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 180 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR++V+RER+R+ F A YWDI AT+DA P A P F ARL SVDG ++ATGRDF Sbjct: 181 TRIVVERERERIKFVPAEYWDISATMDAG---PDAEPRRFGARLVSVDGAKLATGRDFGP 237 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K D+V +L+EA A LATGL A+LSV+SVEEKPY+R+PY PFMTSTLQQEA RK Sbjct: 238 DGRL-KNDDVRLLNEAEARRLATGLTDARLSVSSVEEKPYTRKPYAPFMTSTLQQEASRK 296 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRFS +RTM AQRLYENGYITYMRTDSTTLSE+AI AAR QAR LYG+EY++ PRQY Sbjct: 297 LRFSADRTMRTAQRLYENGYITYMRTDSTTLSETAITAARNQARDLYGDEYLSPQPRQYN 356 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAGE+F TP V ELD D ++LYELIWQRT+ASQMADA+GTTLS+ Sbjct: 357 RKVKNAQEAHEAIRPAGESFRTPGQVAAELDTDGYKLYELIWQRTIASQMADAKGTTLSV 416 Query: 443 RIGG-SAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RI G SA ++ F+ASGRT+TF GFLKAYVE VD GG ADDAE RLP L Q + A Sbjct: 417 RITGTSADGEECTFAASGRTITFAGFLKAYVEAVDSEAGGVADDAESRLPRLAQYQAVTA 476 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 EL+PDGH+TNPP RYTEASLVKA EELGIGRPSTY II T+QDRGYV KKGSALVPSW Sbjct: 477 PELSPDGHSTNPPPRYTEASLVKALEELGIGRPSTYASIISTVQDRGYVWKKGSALVPSW 536 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GL+E+HFG LVDY FTAA+EDELD IA G+++RT WL+ FYFGG+ G DS+ R Sbjct: 537 VAFAVVGLMEKHFGRLVDYDFTAALEDELDRIAEGRQQRTKWLSGFYFGGEVGPDDSIGR 596 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTPQR 681 AGGLKKLVG ++E IDAREVNSI +F D+ GR +YVRVG+ GPYLER ++ + QR Sbjct: 597 AGGLKKLVGSSVEEIDAREVNSIPMFTDDDGRTVYVRVGRYGPYLERPLSDSES----QR 652 Query: 682 ANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILXXXXX 741 ANL D L PDEL + +AE+LFATP EGR LG DPE+GHE++AK+GR+GPYVTE+L Sbjct: 653 ANLPDDLPPDELDIQIAEKLFATPMEGRSLGTDPETGHEVLAKEGRFGPYVTEVL----- 707 Query: 742 XXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEIT 801 R+GSLL+SM L T+T++DALKLL+LPRVVGTDP SG EIT Sbjct: 708 ------------PEGSKGKPRTGSLLKSMSLDTVTIDDALKLLALPRVVGTDPESGTEIT 755 Query: 802 AQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDA 861 AQNGR+GPYLKRG+DSRSL TE+QIF++TL+EALK+YA+PK+ GR++A+A PLRELG D Sbjct: 756 AQNGRFGPYLKRGSDSRSLDTEEQIFTVTLEEALKLYAQPKQRGRRAAAA-PLRELGDDP 814 Query: 862 ASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKR----- 916 SGKP+VIKDGRFGPYVTDGETNASLRKGD V +T +RA EL+A+RRA+ P K+ Sbjct: 815 DSGKPLVIKDGRFGPYVTDGETNASLRKGDSVEELTIDRAVELIAERRAKAPAKKKTASK 874 Query: 917 ----AAKKTTRKSPAKKA 930 A+K T+ K+ A K+ Sbjct: 875 SKSTASKSTSSKTTASKS 892 >tr|C2AJX7|C2AJX7_TSUPA Tax_Id=521096 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Tsukamurella paurometabola DSM 20162] Length = 968 Score = 1204 bits (3116), Expect = 0.0 Identities = 634/922 (68%), Positives = 718/922 (77%), Gaps = 21/922 (2%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESP K +K+ +LGP Y V +S GHIRDLP +P + + W+RLGV+VD DF Sbjct: 16 LVIVESPAKGKKIGDFLGPNYTVRASMGHIRDLPSRDNPLPEADQGKSWSRLGVDVDHDF 75 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 E Y+ S K+S VS ATDGDREGEAIAWHL E LKP+VPVKRMVFH Sbjct: 76 EAHYVTSASKRSTVSELKSLLKQADELYLATDGDREGEAIAWHLQEVLKPKVPVKRMVFH 135 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+ AI AA+ PR+LDM+LVDAQETRRILDRLYGYEVSPVLW+KV LSAGRVQSVA Sbjct: 136 EITQQAIQAAAQEPRELDMNLVDAQETRRILDRLYGYEVSPVLWRKVNQGLSAGRVQSVA 195 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV RER+R+AFR+A YWDI A LDA +A+P TF ARL SVDG RVATGRDFD+ Sbjct: 196 TRIIVDRERERIAFRTAGYWDIAAQLDAGA---EASPRTFGARLVSVDGDRVATGRDFDA 252 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L+K +TVLD RA AL GL GA L+V SVEEKPY+R+PY PFMTSTLQQEA RK Sbjct: 253 QGQLKKPTGITVLDGTRANALVAGLQGANLAVTSVEEKPYTRKPYAPFMTSTLQQEASRK 312 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRF+ +RTM IAQRLYE GYITYMRTDSTTLSE+AI AAR QARQLYG ++V +PRQYT Sbjct: 313 LRFNTDRTMQIAQRLYEGGYITYMRTDSTTLSETAIAAARDQARQLYGADFVHPTPRQYT 372 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAGETF TP A+ L+ DEFRLYELIWQRTVASQMAD +GTTLSL Sbjct: 373 RKVKNAQEAHEAIRPAGETFQTPGALASVLNSDEFRLYELIWQRTVASQMADVKGTTLSL 432 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 RIGG+A + V F+ASGRT+TFPGFL AYVETVDE GGEADDAE RLP LT GQR+ A Sbjct: 433 RIGGTASSGESVEFAASGRTITFPGFLSAYVETVDEQAGGEADDAESRLPQLTKGQRVTA 492 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 ELT H T+PPARYTEASLVK EELGIGRPSTY IIKTIQDRGYV KKG+ALVP W Sbjct: 493 AELTAADHVTSPPARYTEASLVKTLEELGIGRPSTYASIIKTIQDRGYVVKKGNALVPQW 552 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 VAFAV GLLE HFG LVDY FTA+MED+LD IA G+E R DWL FYF GD G + + A Sbjct: 553 VAFAVIGLLEGHFGGLVDYNFTASMEDDLDEIAGGREGRVDWLTRFYF-GDAGDAAAAAA 611 Query: 622 AG------GLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDG 675 G GLK LV NL+ IDARE+NSI L+ D G +YVRVG+ GPYLERT+ +DG Sbjct: 612 DGPGPDSPGLKNLVAANLDAIDAREINSIPLYTDTDGNVVYVRVGRYGPYLERTVAPKDG 671 Query: 676 EPTP--QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVT 733 E P QRAN+ S+TPDELT +AE+LFATPQ+GR LG+DP +GHEIVAK+GR+GPYVT Sbjct: 672 ETEPQVQRANILASMTPDELTEEVAEKLFATPQDGRPLGVDPATGHEIVAKEGRFGPYVT 731 Query: 734 EIL-----XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPR 788 EIL R+GSLL+SMD++T+TL+DAL+LLSLPR Sbjct: 732 EILPEPETDDDTENLDEAAAKPKRKKKTDAPKPRTGSLLKSMDIETVTLDDALRLLSLPR 791 Query: 789 VVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQS 848 VVG DP S EEITAQNGRYGPYLK+GTDSRSLATE+Q+F++TL+EALK+YAEPKR GR + Sbjct: 792 VVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEEQMFTVTLEEALKLYAEPKRRGRGA 851 Query: 849 ASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADR 908 A+APPLRELG D SG MVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADR Sbjct: 852 AAAPPLRELGNDPVSGNAMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADR 911 Query: 909 RARGPVKRAAKKTTRKSPAKKA 930 RARGPVK KK T+K+PAKKA Sbjct: 912 RARGPVK---KKATKKAPAKKA 930 >tr|C8X984|C8X984_NAKMY Tax_Id=479431 SubName: Full=DNA topoisomerase I; EC=5.99.1.2;[Nakamurella multipartita] Length = 978 Score = 1186 bits (3068), Expect = 0.0 Identities = 616/912 (67%), Positives = 705/912 (77%), Gaps = 10/912 (1%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LV+VESP+KA+ ++GYLG YIVESS GHIRDLPR AADVPAK+K EPWARLGV+ + F Sbjct: 16 LVVVESPSKAKTISGYLGDGYIVESSVGHIRDLPRGAADVPAKYKGEPWARLGVDTEHGF 75 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY++SPEKK+ V+ ATD DREGEAIAWHLLETLKP+VPVKRMVFH Sbjct: 76 EPLYVVSPEKKAQVAKLKSLLAGADELYLATDEDREGEAIAWHLLETLKPKVPVKRMVFH 135 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT AI EAA NPR LD +LVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 136 EITPAAIREAAANPRALDENLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 195 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFD- 261 TR+IVQRER+RMAFRS +YW LDA +S F + L++VDG R+A GRDFD Sbjct: 196 TRIIVQRERERMAFRSGTYWG----LDALMSPAGTGAEPFKSALSTVDGRRLAAGRDFDP 251 Query: 262 SLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGR 321 + G L+ +V +LDE A LAT L G +V SVEEKPY+R+PYPPFMTSTLQQEAGR Sbjct: 252 ATGGLKADADVLLLDEDGARTLATALAGGTATVTSVEEKPYTRKPYPPFMTSTLQQEAGR 311 Query: 322 KLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQY 381 KL F+ ERTM AQRLYENG+ITYMRTDSTTLS SA AAR QAR+LYG EYV +PRQY Sbjct: 312 KLGFNSERTMRTAQRLYENGFITYMRTDSTTLSSSAQEAARAQARELYGPEYVPPTPRQY 371 Query: 382 TRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLS 441 TRKVKNAQEAHEAIRPAG+ F TP V ++ GDE+RLYELIWQRT+ASQM DARG TLS Sbjct: 372 TRKVKNAQEAHEAIRPAGDNFRTPGQVANQISGDEYRLYELIWQRTIASQMVDARGLTLS 431 Query: 442 LRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 ++I +A EQ+ VFSASGRT+TFPGFL+AYVETVD GGEADDAERRLP L GQ+LD Sbjct: 432 VKIAATAREQECVFSASGRTITFPGFLRAYVETVDAEAGGEADDAERRLPKLETGQKLDI 491 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 +L P H T PPARYTE SL+ A ++LGIGRPSTYT II+TI DRGYV KKG ALVPSW Sbjct: 492 RDLIPASHVTTPPARYTEPSLIGALQDLGIGRPSTYTSIIRTIIDRGYVWKKGQALVPSW 551 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVAR 621 +AFAV GLLEQHF LVDY FTAAMEDELD IA G+ RTDWL+ FYFGGD G + SV R Sbjct: 552 IAFAVIGLLEQHFSRLVDYNFTAAMEDELDGIADGRIGRTDWLSAFYFGGDLGPAGSVGR 611 Query: 622 AGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTPQR 681 +GGLKKLVG LE IDAREVNS+ L D +GR + VRVG+ GPYLER + GEDGEPT QR Sbjct: 612 SGGLKKLVGERLEDIDAREVNSLPLLTDAEGRQVLVRVGRYGPYLERMVQGEDGEPTAQR 671 Query: 682 ANLNDSLTPDELTLVLAEELFATPQEG--RVLGIDPESGHEIVAKDGRYGPYVTEIL-XX 738 ANL + L PDE+ +AE+LF+ +G LG+DP++GH IVAKDGR+GPYVTE+L Sbjct: 672 ANLPEDLPPDEVDAEVAEKLFSQSGDGGETELGVDPDTGHLIVAKDGRFGPYVTEVLPEA 731 Query: 739 XXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGE 798 R+ SL +SM L TI L AL+LLSLPRVVG DPA G+ Sbjct: 732 APAATGADGTAKKTTKAKAAAKPRTASLFKSMTLDTIDLPTALRLLSLPRVVGVDPADGQ 791 Query: 799 EITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELG 858 EITAQNGRYGPYLK+GTDSRSL +ED +F +TLDEAL +YA+PK GR +A+APPLRE+G Sbjct: 792 EITAQNGRYGPYLKKGTDSRSLTSEDALFDVTLDEALALYAQPKTRGRSAAAAPPLREVG 851 Query: 859 TDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAA 918 D + GKPMVIKDGRFGPYVTDGETNASLRKGDEV ++T ERA+ELLADRRARGP + A Sbjct: 852 IDPSGGKPMVIKDGRFGPYVTDGETNASLRKGDEVETLTVERAAELLADRRARGPAPKRA 911 Query: 919 KKTTRKSPAKKA 930 TTRK A KA Sbjct: 912 --TTRKPAAAKA 921 >tr|D0LEI6|D0LEI6_GORB4 Tax_Id=526226 SubName: Full=DNA topoisomerase I; EC=5.99.1.2;[Gordonia bronchialis] Length = 1031 Score = 1139 bits (2945), Expect = 0.0 Identities = 624/983 (63%), Positives = 715/983 (72%), Gaps = 95/983 (9%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESPTKARK+AGYLG Y+VESSRGHIRDLPR AADVPAK+K +PWARLGVNVD +F Sbjct: 18 LVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGAADVPAKYKGQPWARLGVNVDENF 77 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY++SP+KKS V+ ATDGDREGEAIAWHLLETLKP++PVKRMVFH Sbjct: 78 EPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWHLLETLKPKIPVKRMVFH 137 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITEPAI AAENPRDLD+DLVDAQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 138 EITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 197 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RMAF SA YWDI A +DA A+P TF ARL VD RVATGRDFDS Sbjct: 198 TRIIVERERERMAFVSAEYWDIDANMDAG---KDASPQTFNARLVGVDDARVATGRDFDS 254 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L++AD V VLDE RA ALA L GA ++V+SVEEKPY+RRPY PFMTSTLQQEAGRK Sbjct: 255 RGALKRADGVVVLDETRARALADALDGADITVSSVEEKPYTRRPYAPFMTSTLQQEAGRK 314 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 LRFS +RTM IAQRLYENG+ITYMRTDSTTLSESAINAAR QAR+LYG+ YV +PRQ+T Sbjct: 315 LRFSSDRTMRIAQRLYENGFITYMRTDSTTLSESAINAARAQARELYGDNYVHPTPRQHT 374 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKNAQEAHEAIRPAGE+F TP V +L+ DEFRLYELIWQRTVASQMADA+GTTLSL Sbjct: 375 RKVKNAQEAHEAIRPAGESFRTPGQVAGQLEADEFRLYELIWQRTVASQMADAKGTTLSL 434 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 R+ G+A + VF+ASGRT+TFPGFL AYVETVD+L GG+ADDAE RLP L GQ L A Sbjct: 435 RMTGTASTGETCVFAASGRTITFPGFLSAYVETVDDLAGGQADDAENRLPQLREGQALRA 494 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 EL+ DGH+TNPPAR+TEASLVK EELGIGRPSTY II TIQDRGYV KKG+ALVPSW Sbjct: 495 TELSADGHSTNPPARFTEASLVKVLEELGIGRPSTYASIIGTIQDRGYVVKKGNALVPSW 554 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG-----GDHG-- 614 +AFAV GLLE +F LVDY FTA++ED+LD IASG+E RT WL FYFG +H Sbjct: 555 IAFAVVGLLEAYFQGLVDYDFTASLEDDLDEIASGRENRTRWLTEFYFGDAAPNAEHDAE 614 Query: 615 -VSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTIT-- 671 +A+ GGLKKLVGVNLE IDAREVNSI+LFDDEQGRP+YVRVG+ GPYLER ++ Sbjct: 615 IAGSEIAKHGGLKKLVGVNLEEIDAREVNSIRLFDDEQGRPVYVRVGRFGPYLERNLSAA 674 Query: 672 ---GEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRY 728 D EP QRANL +TPDELTL LAE+LF+TPQEGR LG+DP +GHEIVAK+GR+ Sbjct: 675 SAASPDAEPDLQRANLPADITPDELTLALAEKLFSTPQEGRSLGVDPVTGHEIVAKEGRF 734 Query: 729 GPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPR 788 GPYVTEIL +G + D + + L+ P Sbjct: 735 GPYVTEILPSDDDDDDGNSPATVPAGPTPRDGGGTGG--QGSDAEVVPLD-------TPS 785 Query: 789 VVGT-----DPASGEEITAQNG--RYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEP 841 GT A+ ++ TA+ + GP + G SL I ++TLD+ALK+ + P Sbjct: 786 GGGTATKTAAKAAAKKTTAKKAAKKAGPKPRTG----SLFKTMDISTVTLDDALKLLSLP 841 Query: 842 K--------------RSGR---------------------------------------QS 848 + ++GR + Sbjct: 842 RVVGVDPESGDEITAQNGRYGPYLKKGTDSRSLTSEEQLFSITLDEALKIYSEPKRRGRQ 901 Query: 849 ASAPPLRELG-TDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLAD 907 A+APPLR+LG D+ SGKPMVIKDGRFGPYVTDGETNASLRKGDEVA+IT ERA ELLAD Sbjct: 902 AAAPPLRDLGKEDSVSGKPMVIKDGRFGPYVTDGETNASLRKGDEVATITPERAMELLAD 961 Query: 908 RRARGPVKRAAKKTTRKSPAKKA 930 RRARGP A K +K+PAKKA Sbjct: 962 RRARGP----ATKRAKKAPAKKA 980 Score = 59.3 bits (142), Expect = 2e-06 Identities = 52/168 (30%), Positives = 68/168 (40%), Gaps = 31/168 (18%) Query: 793 DPASGEEITAQNGRYGPYLKRGTDSRSLATEDQI---------FSITLDEALKIYAEPKR 843 D G + + GR+GPYL+R + S A+ D IT DE AE Sbjct: 649 DDEQGRPVYVRVGRFGPYLERNLSAASAASPDAEPDLQRANLPADITPDELTLALAEKLF 708 Query: 844 SGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVT----------DGETNASLRKGDEV 893 S Q R LG D +G +V K+GRFGPYVT DG + A++ G Sbjct: 709 STPQEG-----RSLGVDPVTGHEIVAKEGRFGPYVTEILPSDDDDDDGNSPATVPAGPTP 763 Query: 894 -------ASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA 934 +D L K AAK +K+ AKKA K+A Sbjct: 764 RDGGGTGGQGSDAEVVPLDTPSGGGTATKTAAKAAAKKTTAKKAAKKA 811 >tr|Q8FSS5|Q8FSS5_COREF Tax_Id=152794 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium efficiens] Length = 999 Score = 1119 bits (2895), Expect = 0.0 Identities = 594/959 (61%), Positives = 712/959 (74%), Gaps = 51/959 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKARK+ YLG YIVE+S GHIRDLPR AADVP K+K EPWARLGV+ + F Sbjct: 12 LVIVESATKARKIQPYLGNDYIVEASVGHIRDLPRGAADVPPKYKKEPWARLGVDTEHGF 71 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 72 SPLYVVSPDKKKKVADLKAKLKECDELLLATDPDREGEAIAWHLLEVLKPQVPVRRMVFN 131 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAIL A EN R+LD +LVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 132 EITKPAILAAVENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 191 Query: 203 TRMIVQRERDRMAFRSASYWDIVA--TLDASVSDPKAAPPTFVARLTSVDGLRVATGRDF 260 TR+IV+RER+RMAF SA YWD+ A +D+S P TF ARL ++DG RVA GRDF Sbjct: 192 TRVIVERERERMAFISADYWDLSAQFRIDSSAQADADNPSTFSARLATIDGQRVAQGRDF 251 Query: 261 DSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAG 320 + G L +V V+D+ RA ALA L G ++SVASVEEKPY+RRPY PFMTSTLQQE+G Sbjct: 252 NDRGEL--ISDVVVVDKQRAEALAEALQGQEMSVASVEEKPYTRRPYAPFMTSTLQQESG 309 Query: 321 RKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQ 380 RKL F+ ERTM IAQRLYENG+ITYMRTDST+LSE + AAR QA +LYG EYV+ +PR Sbjct: 310 RKLHFTSERTMRIAQRLYENGHITYMRTDSTSLSEQGLKAARAQALELYGSEYVSPTPRT 369 Query: 381 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTL 440 Y RKVKN+QEAHEAIRPAGETFATP + +LD +EF+LYELIWQRTVASQMADA+GT++ Sbjct: 370 YDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSM 429 Query: 441 SLRIGGSA-GEQQVVFSASGRTLTFPGFLKAYVETVDELVGGE-ADDAERRLPNLTPGQR 498 + I G+A ++ F+A+GRTLTFPGFL+AYVET G + AD+AE+RLP LT G Sbjct: 430 KVTIAGAATSGEKTEFTATGRTLTFPGFLRAYVETTPTADGRDVADNAEKRLPRLTEGDA 489 Query: 499 LDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALV 558 L A ++T DGH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV+ +G+ALV Sbjct: 490 LTATDITADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALV 549 Query: 559 PSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG---GDHGV 615 PSWVAFAV GLLE +F LVDY FT++MEDELD IA+G+E RT+WL+ FYFG D + Sbjct: 550 PSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLSGFYFGDAEADDSM 609 Query: 616 SDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGED 674 ++SVAR GGLK LV NLE IDAR VNS+KLFDDEQGRP++VRVG+ GPY+ER + T + Sbjct: 610 AESVARQGGLKALVDQNLEQIDARSVNSLKLFDDEQGRPVFVRVGRYGPYIERVVGTTPE 669 Query: 675 GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTE 734 GEP QRANL + TPDEL+L +AE+LFATPQ GR LGI+P +G IVAK+GR+GPYVTE Sbjct: 670 GEPEYQRANLPEETTPDELSLEVAEKLFATPQGGRELGINPANGRMIVAKEGRFGPYVTE 729 Query: 735 -ILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT----------------- 776 + R+ +R+ + +T T Sbjct: 730 QVTEDERAGAEAEAEKVVAAERKAEDEQRAADGMRAKNWETKTAATQKEKRINQLVEETL 789 Query: 777 -----------------LEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRS 819 LE+ALKLLSLPR VG DP+ GE ITAQNGRYGPYLK+GTDSRS Sbjct: 790 KPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDGEMITAQNGRYGPYLKKGTDSRS 849 Query: 820 LATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVT 879 L++E+QIF++TLDEA +IYAEPKR GR +A+ PPL+ LG + SGKPM +KDGRFGPYVT Sbjct: 850 LSSEEQIFTVTLDEARRIYAEPKRRGR-TAAQPPLKTLGDNDVSGKPMTVKDGRFGPYVT 908 Query: 880 DGETNASLRKGDEVASITDERASELLADRRAR-----GPVKRAAKKTTRKSPAKKAVKR 933 DG TNASLRKGD S+TD RA+ELL++RRA+ G K+ KKTT+K+ KK K+ Sbjct: 909 DGITNASLRKGDVPESLTDARANELLSERRAKEAADGGAAKKTTKKTTKKTTKKKTTKK 967 >tr|C8NKH1|C8NKH1_COREF Tax_Id=196164 (topA)SubName: Full=Dna topoisomerase; EC=5.99.1.2;[Corynebacterium efficiens YS-314] Length = 999 Score = 1119 bits (2895), Expect = 0.0 Identities = 594/959 (61%), Positives = 712/959 (74%), Gaps = 51/959 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKARK+ YLG YIVE+S GHIRDLPR AADVP K+K EPWARLGV+ + F Sbjct: 12 LVIVESATKARKIQPYLGNDYIVEASVGHIRDLPRGAADVPPKYKKEPWARLGVDTEHGF 71 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 72 SPLYVVSPDKKKKVADLKAKLKECDELLLATDPDREGEAIAWHLLEVLKPQVPVRRMVFN 131 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAIL A EN R+LD +LVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 132 EITKPAILAAVENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 191 Query: 203 TRMIVQRERDRMAFRSASYWDIVA--TLDASVSDPKAAPPTFVARLTSVDGLRVATGRDF 260 TR+IV+RER+RMAF SA YWD+ A +D+S P TF ARL ++DG RVA GRDF Sbjct: 192 TRVIVERERERMAFISADYWDLSAQFRIDSSAQADADNPSTFSARLATIDGQRVAQGRDF 251 Query: 261 DSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAG 320 + G L +V V+D+ RA ALA L G ++SVASVEEKPY+RRPY PFMTSTLQQE+G Sbjct: 252 NDRGEL--ISDVVVVDKQRAEALAEALQGQEMSVASVEEKPYTRRPYAPFMTSTLQQESG 309 Query: 321 RKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQ 380 RKL F+ ERTM IAQRLYENG+ITYMRTDST+LSE + AAR QA +LYG EYV+ +PR Sbjct: 310 RKLHFTSERTMRIAQRLYENGHITYMRTDSTSLSEQGLKAARAQALELYGSEYVSPTPRT 369 Query: 381 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTL 440 Y RKVKN+QEAHEAIRPAGETFATP + +LD +EF+LYELIWQRTVASQMADA+GT++ Sbjct: 370 YDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSM 429 Query: 441 SLRIGGSA-GEQQVVFSASGRTLTFPGFLKAYVETVDELVGGE-ADDAERRLPNLTPGQR 498 + I G+A ++ F+A+GRTLTFPGFL+AYVET G + AD+AE+RLP LT G Sbjct: 430 KVTIAGAATSGEKTEFTATGRTLTFPGFLRAYVETTPTADGRDVADNAEKRLPRLTEGDA 489 Query: 499 LDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALV 558 L A ++T DGH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV+ +G+ALV Sbjct: 490 LTATDITADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALV 549 Query: 559 PSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG---GDHGV 615 PSWVAFAV GLLE +F LVDY FT++MEDELD IA+G+E RT+WL+ FYFG D + Sbjct: 550 PSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLSGFYFGDAEADDSM 609 Query: 616 SDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGED 674 ++SVAR GGLK LV NLE IDAR VNS+KLFDDEQGRP++VRVG+ GPY+ER + T + Sbjct: 610 AESVARQGGLKALVDQNLEQIDARSVNSLKLFDDEQGRPVFVRVGRYGPYIERVVGTTPE 669 Query: 675 GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTE 734 GEP QRANL + TPDEL+L +AE+LFATPQ GR LGI+P +G IVAK+GR+GPYVTE Sbjct: 670 GEPEYQRANLPEETTPDELSLEVAEKLFATPQGGRELGINPANGRMIVAKEGRFGPYVTE 729 Query: 735 -ILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT----------------- 776 + R+ +R+ + +T T Sbjct: 730 QVTEDERAGAEAEAEKVVAAERKAEDEQRAADGMRAKNWETKTAATQKEKRINQLVEETL 789 Query: 777 -----------------LEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRS 819 LE+ALKLLSLPR VG DP+ GE ITAQNGRYGPYLK+GTDSRS Sbjct: 790 KPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDGEMITAQNGRYGPYLKKGTDSRS 849 Query: 820 LATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVT 879 L++E+QIF++TLDEA +IYAEPKR GR +A+ PPL+ LG + SGKPM +KDGRFGPYVT Sbjct: 850 LSSEEQIFTVTLDEARRIYAEPKRRGR-TAAQPPLKTLGDNDVSGKPMTVKDGRFGPYVT 908 Query: 880 DGETNASLRKGDEVASITDERASELLADRRAR-----GPVKRAAKKTTRKSPAKKAVKR 933 DG TNASLRKGD S+TD RA+ELL++RRA+ G K+ KKTT+K+ KK K+ Sbjct: 909 DGITNASLRKGDVPESLTDARANELLSERRAKEAADGGAAKKTTKKTTKKTTKKKTTKK 967 >tr|Q8NTJ8|Q8NTJ8_CORGL Tax_Id=1718 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium glutamicum] Length = 996 Score = 1084 bits (2804), Expect = 0.0 Identities = 585/968 (60%), Positives = 708/968 (73%), Gaps = 59/968 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+ YLG YIVE+S GHIRDLPR AAD+PAK+K EPWARLGV+ D F Sbjct: 15 LVIVESATKAKKIQPYLGNDYIVEASVGHIRDLPRGAADIPAKYKKEPWARLGVDTDRGF 74 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLLE LKP VPV+RMVF+ Sbjct: 75 APLYVVSPDKKKKVADLKAKLKLVDELLLATDPDREGEAIAWHLLEVLKPTVPVRRMVFN 134 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAIL AAEN R+LD +LVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 135 EITKPAILAAAENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 194 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAA--PPTFVARLTSVDGLRVATGRDF 260 TR+IV+RER+RMAF SA YWD+ A +A + + P +F ARL+++DG RVA GRDF Sbjct: 195 TRVIVERERERMAFVSADYWDLSAEFNARENGKADSDNPSSFTARLSTIDGNRVAQGRDF 254 Query: 261 DSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAG 320 + G L E V+D+ RA ALA L G +++V VEEKPY+RRPY PFMTSTLQQE+G Sbjct: 255 NDRGEL--TSEAVVVDKQRAEALAEALEGQEMAVVGVEEKPYTRRPYAPFMTSTLQQESG 312 Query: 321 RKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQ 380 RKL ++ ERTM IAQRLYENG+ITYMRTDST+LSE + AAR QA +LYG EYV+ SPR Sbjct: 313 RKLHYTSERTMRIAQRLYENGHITYMRTDSTSLSEQGMKAARDQALELYGAEYVSPSPRT 372 Query: 381 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTL 440 Y RKVKN+QEAHEAIRPAGETFATP + +LD +EF+LYELIWQRTVASQMADA+GT++ Sbjct: 373 YDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSM 432 Query: 441 SLRIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGE-ADDAERRLPNLTPGQR 498 + IGG+A ++ F+A+GRTLTFPGFL+AYVET G + AD+AE+RLP L+ G Sbjct: 433 KVTIGGTAKTGEKTEFNATGRTLTFPGFLRAYVETTRTADGRDVADNAEKRLPLLSEGDL 492 Query: 499 LDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALV 558 L + + DGH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV+ +G+ALV Sbjct: 493 LKVLSIEADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALV 552 Query: 559 PSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG---GDHGV 615 PSWVAFAV GLLE +F LVDY FT++MEDELD IA+G+E RT+WLN FYFG D + Sbjct: 553 PSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLNGFYFGDAEADQSM 612 Query: 616 SDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGED 674 ++SVAR GGLK LV NLE IDAR VNS+KLFDD +GR + VRVG+ GPY+ER + T + Sbjct: 613 AESVARQGGLKALVDANLEHIDARSVNSLKLFDDAEGRAVNVRVGRYGPYIERIVGTTAE 672 Query: 675 GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTE 734 GEP QRANL + TPDELTL +AE+LFATPQ GR LGI+P +G +VAK+GR+GPYV E Sbjct: 673 GEPEFQRANLPEETTPDELTLEVAEKLFATPQGGRELGINPANGRMVVAKEGRFGPYVIE 732 Query: 735 -ILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT------------LEDAL 781 + R+ +R + +T T +E+ L Sbjct: 733 QVTDSERAGAEAQAEEVVAAERKAEDEQRATDGMRPKNWETKTAANQKEKRINQLVEENL 792 Query: 782 K----------------------LLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRS 819 K LLSLPR VG DP+ E ITAQNGRYGPYLK+G+DSRS Sbjct: 793 KPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDNEVITAQNGRYGPYLKKGSDSRS 852 Query: 820 LATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVT 879 L +E+QIF++TLDEA +IYAEPKR GR +A+ PPL++LG + SGKPM +KDGRFGPYVT Sbjct: 853 LNSEEQIFTVTLDEARRIYAEPKRRGR-AAAQPPLKQLGDNDVSGKPMTVKDGRFGPYVT 911 Query: 880 DGETNASLRKGDEVASITDERASELLADRRAR------GPVKR------AAKKTT-RKSP 926 DG TNASLRKGD S+TD RA+ELL++RRA+ P K+ AAKKTT +K+ Sbjct: 912 DGTTNASLRKGDVPESLTDARANELLSERRAKEAADGGAPAKKTSTKKTAAKKTTAKKTT 971 Query: 927 AKKAVKRA 934 AKK V++A Sbjct: 972 AKKTVRKA 979 >tr|A4QAW2|A4QAW2_CORGB Tax_Id=340322 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium glutamicum] Length = 1004 Score = 1084 bits (2803), Expect = 0.0 Identities = 586/973 (60%), Positives = 708/973 (72%), Gaps = 64/973 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+ YLG YIVE+S GHIRDLPR AAD+PAK+K EPWARLGV+ D F Sbjct: 18 LVIVESATKAKKIQPYLGNDYIVEASVGHIRDLPRGAADIPAKYKKEPWARLGVDTDRGF 77 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLLE LKP VPV+RMVF+ Sbjct: 78 APLYVVSPDKKKKVADLKAKLKLVDELLLATDPDREGEAIAWHLLEVLKPTVPVRRMVFN 137 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAIL AAEN R+LD +LVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 138 EITKPAILAAAENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 197 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAA--PPTFVARLTSVDGLRVATGRDF 260 TR+IV+RER+RMAF SA YWD+ A +A S + P +F ARL+++DG RVA GRDF Sbjct: 198 TRVIVERERERMAFVSADYWDLSAEFNAGESGKADSDNPSSFTARLSTIDGNRVAQGRDF 257 Query: 261 DSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAG 320 + G L E V+D+ RA ALA L G +++V VEEKPY+RRPY PFMTSTLQQE+G Sbjct: 258 NDRGEL--TSEAVVVDKQRAEALAEALEGQEMAVVGVEEKPYTRRPYAPFMTSTLQQESG 315 Query: 321 RKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQ 380 RKL ++ ERTM IAQRLYENG+ITYMRTDST+LSE + AAR QA +LYG EYV+ SPR Sbjct: 316 RKLHYTSERTMRIAQRLYENGHITYMRTDSTSLSEQGMKAARDQALELYGAEYVSPSPRT 375 Query: 381 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTL 440 Y RKVKN+QEAHEAIRPAGETFATP + +LD +EF+LYELIWQRTVASQMADA+GT++ Sbjct: 376 YDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSM 435 Query: 441 SLRIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGE-ADDAERRLPNLTPGQR 498 + IGG+A ++ F+A+GRTLTFPGFL+AYVET G + AD+AE+RLP L+ G Sbjct: 436 KVTIGGTAKTGEKTEFNATGRTLTFPGFLRAYVETTRTADGRDVADNAEKRLPLLSEGDL 495 Query: 499 LDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALV 558 L + + DGH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV+ +G+ALV Sbjct: 496 LKVLGIEADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALV 555 Query: 559 PSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG---GDHGV 615 PSWVAFAV GLLE +F LVDY FT++MEDELD IA+G+E RT+WLN FYFG D + Sbjct: 556 PSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLNGFYFGDAEADQSM 615 Query: 616 SDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGED 674 ++SVAR GGLK LV NLE IDAR VNS+KLFDD +GR + VRVG+ GPY+ER + T + Sbjct: 616 AESVARQGGLKALVDANLEHIDARSVNSLKLFDDAEGRAVNVRVGRYGPYIERIVGTTAE 675 Query: 675 GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTE 734 GEP QRANL + TPDELTL +AE+LFATPQ GR LGI+P +G +VAK+GR+GPYV E Sbjct: 676 GEPEFQRANLPEETTPDELTLEVAEKLFATPQGGRELGINPANGRMVVAKEGRFGPYVIE 735 Query: 735 -ILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT------------LEDAL 781 + R+ +R + +T T +E+ L Sbjct: 736 QVTDSERAGAEAQAEEVVAAERKAEDEQRAADGMRPKNWETKTAANQKEKRINQLVEENL 795 Query: 782 K----------------------LLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRS 819 K LLSLPR VG DP+ E ITAQNGRYGPYLK+G+DSRS Sbjct: 796 KPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDNEVITAQNGRYGPYLKKGSDSRS 855 Query: 820 LATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVT 879 L +E+QIF++TLDEA +IYAEPKR GR +A+ PPL++LG + SGKPM +KDGRFGPYVT Sbjct: 856 LNSEEQIFTVTLDEARRIYAEPKRRGR-AAAQPPLKQLGDNDVSGKPMTVKDGRFGPYVT 914 Query: 880 DGETNASLRKGDEVASITDERASELLADRRAR------GPVKR------AAKKTT----- 922 DG TNASLRKGD S+TD RA+ELL++RRA+ P K+ AAKKTT Sbjct: 915 DGTTNASLRKGDVPESLTDARANELLSERRAKEAADGGAPAKKTSTKKTAAKKTTAKKTT 974 Query: 923 -RKSPAKKAVKRA 934 +K+ AKK V++A Sbjct: 975 AKKTTAKKTVRKA 987 >tr|B1VI08|B1VI08_CORU7 Tax_Id=504474 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium urealyticum] Length = 977 Score = 1076 bits (2783), Expect = 0.0 Identities = 587/963 (60%), Positives = 697/963 (72%), Gaps = 60/963 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+A LG YIVE+S GHIRDLPR AADVPAK+K EPWARLGVNVD F Sbjct: 4 LVIVESATKAKKIAPMLGSDYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDKGF 63 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 E LY++SP+KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVFH Sbjct: 64 EALYVVSPDKKKRVADLRAKLKQVDELLLATDPDREGEAIAWHLLEVLKPKVPVRRMVFH 123 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+ AILEA EN R+LD +LVDAQE+RR+LDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 124 EITKSAILEAVENTRELDYNLVDAQESRRVLDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 183 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAA----PPTFVARLTSVDGLRVATGR 258 TR+IV+RER+RMAFR+A YWD+ A L DP A P +F A+L +V G R+A GR Sbjct: 184 TRVIVERERERMAFRAADYWDLTAEL---TIDPAARLDGDPASFQAKLATVGGQRIAQGR 240 Query: 259 DFDSLGTLR--KADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQ 316 DF TL+ K+ VLDE RA LA+G+ G +L VA+VEEKPY+RRPYPPFMTSTLQ Sbjct: 241 DFKDDATLKASKSGAPLVLDEQRAKQLASGIKGEELHVANVEEKPYTRRPYPPFMTSTLQ 300 Query: 317 QEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVAS 376 QEAGRKLRF+ ERTM IAQRLYENGYITYMRTDSTTLS + INAAR QA QLYG+++VA Sbjct: 301 QEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSTAGINAARAQAAQLYGQQFVAD 360 Query: 377 SPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADAR 436 PRQYTRKVKN+QEAHEAIRPAGE F TP + ++LD +EF+LYELIWQRTVASQMADAR Sbjct: 361 GPRQYTRKVKNSQEAHEAIRPAGERFQTPGQLAQKLDAEEFKLYELIWQRTVASQMADAR 420 Query: 437 GTTLSLRIGGSAGE----QQVVFSASGRTLTFPGFLKAYVETVDELVGGE-ADDAERRLP 491 GT++ + I G++GE +V F+A+GRT+TFPGFLKAYVE G + AD+AE+RLP Sbjct: 421 GTSMKVTIAGTSGEPEAGTEVEFTATGRTVTFPGFLKAYVEVSRTAEGKDVADNAEKRLP 480 Query: 492 NLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVH 551 +T G L A ++T DGHTT PPARYTEASLV+ EELGIGRPSTY II+TIQDRGYV Sbjct: 481 QVTEGVFLTAEDVTADGHTTTPPARYTEASLVRKMEELGIGRPSTYASIIRTIQDRGYVL 540 Query: 552 KKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGG 611 +G+ALVPSWVAFAV GLLEQ+FG LVDY FT+AMED+LDAIA G E RT WL FYFGG Sbjct: 541 PRGNALVPSWVAFAVVGLLEQNFGALVDYDFTSAMEDQLDAIAEGNEDRTKWLEGFYFGG 600 Query: 612 DHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTIT 671 G S ++ GLK +V NLE IDAR VNS+ LFDD G PI VRVG+ GPYLER + Sbjct: 601 --GTS---SQNYGLKNVVAQNLESIDARRVNSLHLFDDANGVPIVVRVGRYGPYLERMVK 655 Query: 672 GEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPY 731 + GE QRANL +S+TPDELTL +AE+LFATPQ GR LG +PE+G IVA++GR+GPY Sbjct: 656 NDKGEEEAQRANLPESMTPDELTLEVAEKLFATPQSGRELGRNPENGRMIVAREGRFGPY 715 Query: 732 VTEIL---XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTI----------TLE 778 VTE+L + G S +T LE Sbjct: 716 VTEVLGEDEEAEVTAKAEKVFLAERDEEDAERAKEGKKPLSRGTKTFENKKAKRIKEILE 775 Query: 779 DALKLLSLPRVVGTDPAS----------------------GEEITAQNGRYGPYLKRGTD 816 + LK + +PA+ GE ITAQNGRYGPYLK+G D Sbjct: 776 ETLKPKTASLFASMEPATVTLEDALKLMSLPREVGVDPADGEVITAQNGRYGPYLKKGWD 835 Query: 817 SRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGP 876 SRSL +E+++F+ITLDEA +IYAEPKR GR +A+ PPL+ LG + SGKPM +K+GRFGP Sbjct: 836 SRSLGSEEELFNITLDEARRIYAEPKRRGR-AAAKPPLKRLGDNDVSGKPMSVKEGRFGP 894 Query: 877 YVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAA--KKTTRKS---PAKKAV 931 YVTDG TNASLR+GD ++TD RA+ELL++RRA+ K AA K+TRKS AKKA Sbjct: 895 YVTDGTTNASLRRGDTPETLTDARANELLSERRAKDAEKAAAGPAKSTRKSTKKTAKKAA 954 Query: 932 KRA 934 K+A Sbjct: 955 KKA 957 >tr|C8RV02|C8RV02_CORJE Tax_Id=525262 (topA)SubName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium jeikeium ATCC 43734] Length = 997 Score = 1070 bits (2767), Expect = 0.0 Identities = 590/974 (60%), Positives = 696/974 (71%), Gaps = 65/974 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+A LGP YIVE+S GHIRDLPR AADVPAK+K EPWARLGVNVD DF Sbjct: 9 LVIVESATKAKKIAPILGPNYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDKDF 68 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 E LY++SP+KK VS ATD DREGEAIAWHLLE LKP+VPV+RMVFH Sbjct: 69 EALYVVSPDKKKKVSDLKAKLKQVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFH 128 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+ AILEAA+N R+LD DLVDAQE+RR+LDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 129 EITKNAILEAAQNTRELDYDLVDAQESRRVLDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 188 Query: 203 TRMIVQRERDRMAFRSASYWDIVAT---LDA-SVSDPKAAPPTFVARLTSVDGLRVATGR 258 TR+IV+RER+RM F +A YWD+ AT +DA S S AAP +F ARL +V G RVA GR Sbjct: 189 TRVIVERERERMKFVAAEYWDLSATFGVVDAVSSSLDDAAPDSFEARLATVAGKRVAQGR 248 Query: 259 DFDSLGTLR-KADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQ 317 DF G L+ A E VLD A+A +LA GL G + +V +VEEKPY+RRPYPPFMTSTLQQ Sbjct: 249 DFGDDGKLKASAKETFVLDGAKAKSLADGLQGQEFTVTAVEEKPYTRRPYPPFMTSTLQQ 308 Query: 318 EAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASS 377 EAGRKLRF+ ERTM IAQRLYENG+ITYMRTDSTTLS + I AAR QA++LYG ++VA Sbjct: 309 EAGRKLRFTSERTMRIAQRLYENGHITYMRTDSTTLSTAGIEAARKQAKELYGAKFVADG 368 Query: 378 PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARG 437 PRQY+RKVKN+QEAHEAIRPAGETF TP + +LD +EF+LYELIWQRTVASQMADA+G Sbjct: 369 PRQYSRKVKNSQEAHEAIRPAGETFQTPGQLSNQLDAEEFKLYELIWQRTVASQMADAKG 428 Query: 438 TTLSLRIGGSAGEQQVV-FSASGRTLTFPGFLKAYVETVDELVGGE-ADDAERRLPNLTP 495 ++ L + G A + F+A+GRTLTFPGFLKAYVE G + AD+AE+RLP LT Sbjct: 429 QSMKLTVAGDAKSGETCEFTATGRTLTFPGFLKAYVEVSRTADGRDVADNAEKRLPQLTK 488 Query: 496 GQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGS 555 G L+A ++ DGH+TNPPARYTEASLVK EE+GIGRPSTY II+TIQDRGYV +G+ Sbjct: 489 GDELNARDVAADGHSTNPPARYTEASLVKKMEEMGIGRPSTYASIIRTIQDRGYVLPRGN 548 Query: 556 ALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGD--- 612 ALVPSWVAFAV GLLEQ+FG LVDY FT+AMEDELDAIA+G E R +WL FYFG Sbjct: 549 ALVPSWVAFAVIGLLEQNFGALVDYDFTSAMEDELDAIAAGNEDRVNWLKGFYFGDSSRP 608 Query: 613 HGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLER---- 668 V R GGLK +VG NLE IDAR VNS+ +FDDE G PI VRVG+ GPYLER Sbjct: 609 EAPGAVVPRLGGLKHIVGDNLEQIDARRVNSLHIFDDENGVPIVVRVGRYGPYLERIKPV 668 Query: 669 -TITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGR 727 E EP QRANL +S+TPD LTL +AE+LFATPQ GR LG +P +G IVA++GR Sbjct: 669 PAGAPEGTEPEVQRANLPESMTPDGLTLEVAEKLFATPQGGRELGTNPANGRTIVAREGR 728 Query: 728 YGPYVTEIL-XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT---------- 776 YGPYVTE+L R + + +T T Sbjct: 729 YGPYVTEVLGEDEESRVAEEAVKVWEAERDEQDREREAEGKKPLSRETKTAQAQKEKRVK 788 Query: 777 --LEDALKLLSLPRVVGTDPAS----------------------GEEITAQNGRYGPYLK 812 +E+ LK + G +PAS E ITAQNGRYGPYLK Sbjct: 789 QIVEETLKPKTASLFSGMEPASVTLEEALKLMSLPREVGVDPSDNEVITAQNGRYGPYLK 848 Query: 813 RGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDG 872 +G DSRSLA E+QIF+ITLDEA +IYAEPKR GR +A+ PPL++LG + SGKPM +KDG Sbjct: 849 KGKDSRSLANEEQIFTITLDEARRIYAEPKRRGR-AAAQPPLKQLGDNDVSGKPMSVKDG 907 Query: 873 RFGPYVTDGETNASLRKGDEVASITDERASELLADRRA-------------RGPVKRAAK 919 RFG YVTDG TNASLRKGD ++TD RA+ELL++RRA R K++AK Sbjct: 908 RFGAYVTDGTTNASLRKGDTPETMTDARANELLSERRAKQAAEGSAPAKSSRKAAKKSAK 967 Query: 920 KTTRKSPAKKAVKR 933 KTT+K+ AKK+ K+ Sbjct: 968 KTTKKA-AKKSTKK 980 >tr|Q4JSS2|Q4JSS2_CORJK Tax_Id=306537 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium jeikeium] Length = 997 Score = 1065 bits (2754), Expect = 0.0 Identities = 589/975 (60%), Positives = 697/975 (71%), Gaps = 67/975 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+A LGP YIVE+S GHIRDLPR AADVPAK+K EPWARLGVNVD DF Sbjct: 9 LVIVESATKAKKIAPILGPNYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDKDF 68 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 E LY++SP+KK VS ATD DREGEAIAWHLLE LKP+VPV+RMVFH Sbjct: 69 EALYVVSPDKKKKVSDLKAKLKQVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFH 128 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+ AILEAA+N R+LD DLVDAQE+RR+LDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 129 EITKNAILEAAQNTRELDYDLVDAQESRRVLDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 188 Query: 203 TRMIVQRERDRMAFRSASYWDIVAT---LDA-SVSDPKAAPPTFVARLTSVDGLRVATGR 258 TR+IV+RER+RM F +A YWD+ AT +DA S S AAP +F ARL +V G RVA GR Sbjct: 189 TRVIVERERERMKFIAAEYWDLSATFGVVDAVSSSLDDAAPDSFEARLATVAGKRVAQGR 248 Query: 259 DFDSLGTLR-KADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQ 317 DF G L+ A E VLD A+A +LA GL G + +V +VEEKPY+RRPYPPFMTSTLQQ Sbjct: 249 DFGDDGKLKASAKETFVLDGAKAKSLADGLQGQEFTVTAVEEKPYTRRPYPPFMTSTLQQ 308 Query: 318 EAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASS 377 EAGRKLRF+ ERTM IAQRLYENG+ITYMRTDSTTLS + I AAR QA++LYG ++VA Sbjct: 309 EAGRKLRFTSERTMRIAQRLYENGHITYMRTDSTTLSTAGIEAARKQAKELYGAKFVADG 368 Query: 378 PRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARG 437 PRQY+RKVKN+QEAHEAIRPAGETF TP + +LD +EF+LYELIWQRTVASQMADA+G Sbjct: 369 PRQYSRKVKNSQEAHEAIRPAGETFQTPGQLSNQLDAEEFKLYELIWQRTVASQMADAKG 428 Query: 438 TTLSLRIGGSAGEQQVV-FSASGRTLTFPGFLKAYVETVDELVGGE-ADDAERRLPNLTP 495 ++ L + G A + F+A+GRTLTFPGFLKAYVE G + AD+AE+RLP LT Sbjct: 429 QSMKLTVAGDAKSGETCEFTATGRTLTFPGFLKAYVEVSRTADGRDVADNAEKRLPQLTK 488 Query: 496 GQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGS 555 G L+A ++ DGH+TNPPARYTEASLVK EE+GIGRPSTY II+TIQDRGYV +G+ Sbjct: 489 GDELNARDVAADGHSTNPPARYTEASLVKKMEEMGIGRPSTYASIIRTIQDRGYVLPRGN 548 Query: 556 ALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGV 615 ALVPSWVAFAV GLLEQ+FG LVDY FT+AMEDELDAIA+G E R +WL FYF GD Sbjct: 549 ALVPSWVAFAVIGLLEQNFGALVDYDFTSAMEDELDAIAAGNEDRVNWLKGFYF-GDSSR 607 Query: 616 SDS----VARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTIT 671 D+ V R GGLK +VG NLE IDAR VNS+ +FDDE G PI VRVG+ GPYLER Sbjct: 608 PDAPGAVVPRLGGLKHIVGDNLEQIDARRVNSLHIFDDENGVPIVVRVGRYGPYLERIKP 667 Query: 672 GEDG-----EPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDG 726 G EP QRANL +S++PD LTL +AE+LFATPQ GR LG +P +G IVA++G Sbjct: 668 VPQGAPEGTEPEVQRANLPESMSPDGLTLEVAEKLFATPQGGRELGTNPANGRTIVAREG 727 Query: 727 RYGPYVTEIL-XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT--------- 776 RYGPYVTE+L R + + +T T Sbjct: 728 RYGPYVTEVLGEDEESRVAEEAVKVWEAERDEQDREREAEGKKPLSRETKTAQAQKEKRV 787 Query: 777 ---LEDALKLLSLPRVVGTDPAS----------------------GEEITAQNGRYGPYL 811 +E+ LK + +PAS E ITAQNGRYGPYL Sbjct: 788 KQIVEETLKPKTASLFSDMEPASVTLEEALKLMSLPREVGVDPSDNEVITAQNGRYGPYL 847 Query: 812 KRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKD 871 K+G DSRSLA E+QIF+ITLDEA +IYAEPKR GR +A+ PPL++LG + SGKPM +K+ Sbjct: 848 KKGKDSRSLANEEQIFTITLDEARRIYAEPKRRGR-AAAQPPLKQLGDNDVSGKPMSVKE 906 Query: 872 GRFGPYVTDGETNASLRKGDEVASITDERASELLADRRA-------------RGPVKRAA 918 GRFG YVTDG TNASLRKGD ++TD RA+ELL++RRA R K++A Sbjct: 907 GRFGAYVTDGTTNASLRKGDTPETMTDARANELLSERRAKQAAEGSAPAKSSRKAAKKSA 966 Query: 919 KKTTRKSPAKKAVKR 933 KKTT+K+ AKK K+ Sbjct: 967 KKTTKKA-AKKTTKK 980 >tr|C3PJV8|C3PJV8_CORA7 Tax_Id=548476 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium aurimucosum] Length = 972 Score = 1065 bits (2754), Expect = 0.0 Identities = 568/951 (59%), Positives = 691/951 (72%), Gaps = 55/951 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+ YLG +YIVE+S GHIRDLPR AADVPAK+K E WARLGVN + +F Sbjct: 11 LVIVESATKAKKIQPYLGDKYIVEASVGHIRDLPRGAADVPAKYKKESWARLGVNPEDNF 70 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY+IS +KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 71 TPLYVISQDKKKKVADLKAKLKQCDQLYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFN 130 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+ AILEAAEN R+LD +L+DAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 131 EITKSAILEAAENTRELDENLIDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 190 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RMAF A YWD+ ATL ++ P F ARL+++DG RVA GRDFD Sbjct: 191 TRVIVERERERMAFIPAEYWDLTATLKST--------PDFDARLSALDGKRVAAGRDFDD 242 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K+DEV V+ +A+A LA+ L G+ ++VASVE KPYSR+P PFMTSTLQQEAGR+ Sbjct: 243 RGQL-KSDEVVVVKQAQAEQLASALEGSTMTVASVEHKPYSRKPSAPFMTSTLQQEAGRR 301 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 L ++ ERTM IAQRLYENG+ITYMRTDST+LS+ ++AAR A ++G E+VA PR Y Sbjct: 302 LHYTSERTMRIAQRLYENGHITYMRTDSTSLSKQGLDAAREAATSIFGAEFVADGPRTYD 361 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKN+QEAHEAIRPAGE FATP + +LD +E++LYELIW+RTVASQMADA+GT++ + Sbjct: 362 RKVKNSQEAHEAIRPAGERFATPGQLAGQLDAEEYKLYELIWKRTVASQMADAKGTSMKV 421 Query: 443 RIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDAV 502 SAG FSA+GRT+TFPGFLKAY E V + E RLP+L G L Sbjct: 422 TAAVSAGGHDADFSATGRTITFPGFLKAY-----EDVASKGSKEESRLPHLNEGDTLKTA 476 Query: 503 ELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWV 562 +T DGH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV +G+ALVPSWV Sbjct: 477 AVTADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVLSRGNALVPSWV 536 Query: 563 AFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHG---VSDSV 619 AFAV GLLE +F LVDY FT++MEDELDAIA+G E TDWLNNFYFG + S+ Sbjct: 537 AFAVVGLLENNFTELVDYDFTSSMEDELDAIAAGSENGTDWLNNFYFGNTEAGERKAASI 596 Query: 620 ARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGEDGEPT 678 AR GGLK LV +NLE IDAR+VNS++L+ D +GR ++VRVG+ GPY+ER + T EDG Sbjct: 597 ARHGGLKSLVDINLEAIDARQVNSLRLYTDAEGRDVFVRVGRYGPYIERAVGTNEDGTVE 656 Query: 679 PQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTE-ILX 737 QRANL++++TPDEL LAE+LFATPQ GR LG +PE+G IVAK+GR+GPYVTE + Sbjct: 657 YQRANLSETVTPDELNEALAEKLFATPQGGRELGQNPENGRTIVAKEGRFGPYVTEQVRD 716 Query: 738 XXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT------------LEDALK--- 782 R+ R+ + +T T +E+ LK Sbjct: 717 DEREKAEAEAEEIVKEERAAEDAQRAAEGKRAKNWETKTAAKQKEKRIAEYVEEKLKPGT 776 Query: 783 -------------------LLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATE 823 LL+LPR VG DP+ GE ITAQNGRYGPYLK+G DSRSLA E Sbjct: 777 ASLFASMEPSSVTLEEALKLLNLPREVGVDPSDGEVITAQNGRYGPYLKKGKDSRSLAKE 836 Query: 824 DQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGET 883 +QIFSITLDEA +IYAEPKR GR +A+ PP+++LG + SGKPM +KDGRFGPYVTDG T Sbjct: 837 EQIFSITLDEARRIYAEPKRRGR-AAAQPPIKQLGDNDVSGKPMTVKDGRFGPYVTDGTT 895 Query: 884 NASLRKGDEVASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA 934 NASLR+GD+ +TD RA+ELL++RRA+ AKK+T+KS KK+ K+A Sbjct: 896 NASLRRGDDPEQLTDARANELLSERRAKDAANGGAKKSTKKS-TKKSTKKA 945 >tr|C8NXE9|C8NXE9_9CORY Tax_Id=585529 (topA)SubName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium genitalium ATCC 33030] Length = 988 Score = 1064 bits (2751), Expect = 0.0 Identities = 569/959 (59%), Positives = 687/959 (71%), Gaps = 59/959 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+ YLG Y VE+S GHIRDLP AAD+PAK+K E WA+LGVN + F Sbjct: 25 LVIVESQTKAKKIQKYLGDNYFVEASVGHIRDLPGRAADIPAKYKKETWAKLGVNPEDGF 84 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 +P+Y++SP+KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 85 QPIYVVSPDKKKKVTDLKDKLKRSDKLLLATDPDREGEAIAWHLLEVLKPKVPVERMVFN 144 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EITE AI EAAEN R+LDMDLVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 145 EITESAIREAAENTRELDMDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 204 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RMAF SA YWD+ ATL+A S A P F A+L++++G ++A GRDF+ Sbjct: 205 TRVIVERERERMAFVSAEYWDVTATLNAG-SGGAANPDDFDAKLSTINGTKIAQGRDFND 263 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G RK D V V+D+ RA LA GL G L+VASVE KPYSRRPY PFMTSTLQQ AG K Sbjct: 264 RGG-RKNDVVVVVDKQRAETLAEGLTGQDLTVASVESKPYSRRPYAPFMTSTLQQAAGAK 322 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 L F+ RTM IAQRLYENG+ITYMRTDST+LS+ ++AAR AR+LYG YV PR+Y Sbjct: 323 LHFTSARTMRIAQRLYENGHITYMRTDSTSLSKQGLDAARNAARELYGSNYVTDQPRRYD 382 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKN+QEAHEAIRPAGE FATP + LD +EF+LYELIWQRTVASQM D+RGTT+++ Sbjct: 383 RKVKNSQEAHEAIRPAGERFATPGELASALDTEEFKLYELIWQRTVASQMEDSRGTTMTV 442 Query: 443 RIGGSAGE-QQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDA 501 + G A + V +ASGRT+TFPG+L+AY +T D+ E+ LP L+ G L A Sbjct: 443 VVAGQATDGTDVELTASGRTITFPGWLRAYADT--------QDNKEKHLPQLSEGDALTA 494 Query: 502 VELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW 561 E+T DGH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV +G+ALVP+W Sbjct: 495 REVTADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVATRGNALVPTW 554 Query: 562 VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG---GDHGVSDS 618 VAF+V GL+EQ+F LVDY FT++MEDELD IA G E RT+WL FYFG +++ Sbjct: 555 VAFSVVGLMEQNFDALVDYEFTSSMEDELDEIAQGTENRTEWLTGFYFGDAEASDTTAEA 614 Query: 619 VARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGEDGEP 677 VAR GGLK ++ NLE IDAR+VNS++LF DE+ RP+YVRVG+ GPYLER + G DGEP Sbjct: 615 VARRGGLKHIIEANLEAIDARKVNSLELFRDEEDRPVYVRVGRYGPYLERQVGVGSDGEP 674 Query: 678 TPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL- 736 QRANL +S TPDE+T +AE+LFATP GR LG +P++G IVAK+GRYGPYVTE++ Sbjct: 675 EFQRANLPESTTPDEVTQEMAEKLFATPPTGRELGQNPDTGRMIVAKEGRYGPYVTELVR 734 Query: 737 XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDA---------------- 780 R+ R+ + +T T E A Sbjct: 735 DDERATAEAHAQEVIAAERAEEDAQRAAEGKRAKNWETKTAEAARVKRTEQLIDEQLKPA 794 Query: 781 ------------------LKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLAT 822 LKLLSLPR VG DP+ GE ITAQNGRYGPYLK+G DSRSLA Sbjct: 795 TASLFSSMEPSTVTLEDALKLLSLPREVGEDPSDGEMITAQNGRYGPYLKKGNDSRSLAN 854 Query: 823 EDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGE 882 EDQIF++TLDEA +IYAEPKR GR +A+ PPL+ LG + SGKPM +KDGRFGPYVTDGE Sbjct: 855 EDQIFTVTLDEARRIYAEPKRRGR-AAAQPPLKALGDNDVSGKPMTVKDGRFGPYVTDGE 913 Query: 883 TNASLRKGDEVASITDERASELLADRRAR--------GPVKRAAKKTTRKSPAKKAVKR 933 TNASL++GD ++TD RA+ELL+ RRAR G K KK ++K +KKA K+ Sbjct: 914 TNASLQRGDTPETMTDARANELLSARRAREAEDAAAGGAKKATKKKASKKKASKKAAKK 972 Score = 65.9 bits (159), Expect = 3e-08 Identities = 59/236 (25%), Positives = 101/236 (42%), Gaps = 40/236 (16%) Query: 666 LERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKD 725 ++RT D + P A+L S+ P +TL A +L + P+E +G DP G I A++ Sbjct: 780 VKRTEQLIDEQLKPATASLFSSMEPSTVTLEDALKLLSLPRE---VGEDPSDGEMITAQN 836 Query: 726 GRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLS 785 GRYGPY+ + S SL + T+TL++A ++ + Sbjct: 837 GRYGPYLKK-------------------------GNDSRSLANEDQIFTVTLDEARRIYA 871 Query: 786 LPR------------VVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDE 833 P+ +G + SG+ +T ++GR+GPY+ G + SL D ++T Sbjct: 872 EPKRRGRAAAQPPLKALGDNDVSGKPMTVKDGRFGPYVTDGETNASLQRGDTPETMTDAR 931 Query: 834 ALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRK 889 A ++ + + + A+A ++ AS K K + T A RK Sbjct: 932 ANELLSARRAREAEDAAAGGAKKATKKKASKKKASKKAAKKPKQTTKRVVKAGTRK 987 Score = 58.2 bits (139), Expect = 5e-06 Identities = 47/135 (34%), Positives = 69/135 (51%), Gaps = 17/135 (12%) Query: 805 GRYGPYLKR----GTDSRSLATEDQI-FSITLDEALKIYAEPKRSGRQSASAPPLRELGT 859 GRYGPYL+R G+D + S T DE + AE + A+ P RELG Sbjct: 656 GRYGPYLERQVGVGSDGEPEFQRANLPESTTPDEVTQEMAE-----KLFATPPTGRELGQ 710 Query: 860 DAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAAK 919 + +G+ +V K+GR+GPYVT+ L + DE A+ + A E++A RA +RAA+ Sbjct: 711 NPDTGRMIVAKEGRYGPYVTE------LVRDDERAT-AEAHAQEVIAAERAEEDAQRAAE 763 Query: 920 KTTRKSPAKKAVKRA 934 K+ K + A Sbjct: 764 GKRAKNWETKTAEAA 778 >tr|C2GG61|C2GG61_9CORY Tax_Id=548478 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium glucuronolyticum ATCC 51866] Length = 958 Score = 1063 bits (2750), Expect = 0.0 Identities = 570/949 (60%), Positives = 690/949 (72%), Gaps = 49/949 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA K+A YLGP YIVE+S GHIRDLPR+AA++PAK+K EPWARLGV+ + F Sbjct: 5 LVIVESQTKANKIAPYLGPDYIVEASVGHIRDLPRSAAEIPAKYKKEPWARLGVDTEHGF 64 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 +PLY++S EKK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 65 QPLYLVSSEKKKKVADLKKKLKEVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFN 124 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAI+ AA+N R+LD DLV AQE RRI+DRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 125 EITKPAIIAAAQNTRELDEDLVSAQEARRIVDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 184 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RMAF SA YWD+ A LD + + F ARLT+VDG RVA GRDF Sbjct: 185 TRVIVERERERMAFVSADYWDLTAELDTKKDEINS---VFNARLTAVDGKRVAQGRDFTD 241 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K ++V VLD+ +A+A A L GA++SV +VEEKPY+R+PYPPFMTSTLQQEAGRK Sbjct: 242 RGEL-KDNKVVVLDKEKASAHAEALKGAEVSVDAVEEKPYTRKPYPPFMTSTLQQEAGRK 300 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 L ++ +RTM IAQRLYENG+ITYMRTDSTTLS+S + AAR QA +LYGE+YVA SPRQYT Sbjct: 301 LHYTSDRTMRIAQRLYENGHITYMRTDSTTLSQSGLQAARNQAIELYGEKYVADSPRQYT 360 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKN+QEAHEAIRPAG+ FATP + LD +EFRLYELIWQRTVASQMA+ARGT++ + Sbjct: 361 RKVKNSQEAHEAIRPAGDRFATPGELHGRLDAEEFRLYELIWQRTVASQMANARGTSMKV 420 Query: 443 RIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGE--ADDAERRLPNLTPGQRLD 500 + + SA+GR++TFPGFLKAYVET EL G AD+AE LP LT GQ + Sbjct: 421 TLSA----DNLTLSATGRSITFPGFLKAYVET-SELSDGRKVADNAESHLPVLTEGQTVH 475 Query: 501 AVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPS 560 A + TP+GH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV +G+ALVPS Sbjct: 476 AEDATPEGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVFSRGNALVPS 535 Query: 561 WVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVA 620 WVAFAV GL+EQ+FG LVDY FT+ +ED+LD+IA+G RT+WL FYFG + +SV Sbjct: 536 WVAFAVVGLMEQNFGSLVDYDFTSELEDQLDSIATGNTDRTNWLTGFYFGDANAPEESVP 595 Query: 621 RAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGEDGEPTP 679 GGLK +VG NLE IDAREVNS++LF D++GR I VRVG+ GPYLER + +DGEP Sbjct: 596 YQGGLKAIVGQNLENIDAREVNSLRLFADKEGRDIVVRVGRYGPYLERVVGLTDDGEPEF 655 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL-XX 738 QRANL ++ TPDELTL AE+LFATPQ GR LG +P++G +VAK+GRYGPYVTE++ Sbjct: 656 QRANLPEATTPDELTLEFAEKLFATPQSGRELGTNPDNGRTVVAKEGRYGPYVTELVRDD 715 Query: 739 XXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT------------LEDALKLLSL 786 R R + +T T +++ LK + Sbjct: 716 ERSVVEKQALEVVQKEREEEDAQRKAEGKRKKNWETKTAEKQKQKRIDEFIQEKLKPGTA 775 Query: 787 PRVVGTDPAS---------------------GEEITAQNGRYGPYLKRGTDSRSLATEDQ 825 DPA+ GE ITAQNGRYGPYLK+G+DSRSLA+ED Sbjct: 776 SLFSSMDPAAVTLEEALKLLSLPRELGADDDGEIITAQNGRYGPYLKKGSDSRSLASEDL 835 Query: 826 IFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNA 885 IF+ITLD+A IY EPKR GRQ+A PPL+ LG + SGKPMV+KDGRFGPYVTDG+TNA Sbjct: 836 IFTITLDQAKAIYREPKRRGRQAAK-PPLKTLGNNDVSGKPMVVKDGRFGPYVTDGDTNA 894 Query: 886 SLRKGDEVASITDERASELLADRRARGPVKRAAKK--TTRKSPAKKAVK 932 SL++GD ++TD RA ELL++RRAR KK T +K+ KKA K Sbjct: 895 SLKRGDTPETLTDARACELLSERRAREAAGEVGKKKTTRKKATRKKATK 943 Score = 59.3 bits (142), Expect = 2e-06 Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 27/147 (18%) Query: 797 GEEITAQNGRYGPYLKRG---TDS-------RSLATEDQIFSITLDEALKIYAEPKRSGR 846 G +I + GRYGPYL+R TD +L +TL+ A K++A P+ Sbjct: 627 GRDIVVRVGRYGPYLERVVGLTDDGEPEFQRANLPEATTPDELTLEFAEKLFATPQSG-- 684 Query: 847 QSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLA 906 RELGT+ +G+ +V K+GR+GPYVT+ L + DE S+ +++A E++ Sbjct: 685 --------RELGTNPDNGRTVVAKEGRYGPYVTE------LVRDDE-RSVVEKQALEVVQ 729 Query: 907 DRRARGPVKRAAKKTTRKSPAKKAVKR 933 R +R A+ +K+ K ++ Sbjct: 730 KEREEEDAQRKAEGKRKKNWETKTAEK 756 >tr|C0VRF5|C0VRF5_9CORY Tax_Id=548477 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium glucuronolyticum ATCC 51867] Length = 958 Score = 1062 bits (2746), Expect = 0.0 Identities = 569/949 (59%), Positives = 688/949 (72%), Gaps = 49/949 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA K+A YLGP YIVE+S GHIRDLPR+AA++PAK+K EPWARLGV+ + F Sbjct: 5 LVIVESQTKANKIAPYLGPDYIVEASVGHIRDLPRSAAEIPAKYKKEPWARLGVDTEHGF 64 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 +PLY++S +KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 65 QPLYLVSSDKKKKVADLKKKLKEVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFN 124 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAI+ AA+N R+LD DLV AQE RRI+DRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 125 EITKPAIIAAAQNTRELDEDLVSAQEARRIVDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 184 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RMAF SA YWD+ A LD ++ A F ARLT+VDG RVA GRDF Sbjct: 185 TRVIVERERERMAFISADYWDLTAELDTKKNELNNA---FSARLTAVDGKRVAQGRDFSD 241 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G L K D + VLD+ +A A AT L GA++ V +VEEKPY+R+PYPPFMTSTLQQEAGRK Sbjct: 242 RGEL-KDDTLVVLDKDQATAYATSLKGAEVRVDAVEEKPYTRKPYPPFMTSTLQQEAGRK 300 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 L ++ +RTM IAQRLYENG+ITYMRTDSTTLS+S + AAR QA +LYGE+YVA SPRQYT Sbjct: 301 LHYTSDRTMRIAQRLYENGHITYMRTDSTTLSQSGLQAARNQAIELYGEKYVADSPRQYT 360 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKN+QEAHEAIRPAG+ FATP + LD +EFRLYELIWQRTVASQMA+A GT++ + Sbjct: 361 RKVKNSQEAHEAIRPAGDRFATPGELHGRLDAEEFRLYELIWQRTVASQMANAHGTSMKV 420 Query: 443 RIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGE--ADDAERRLPNLTPGQRLD 500 + + SA+GR++TFPGFLKAYVET EL G AD+AE LP LT GQ + Sbjct: 421 TLSA----DNLTLSATGRSITFPGFLKAYVET-SELSDGRKVADNAESHLPVLTEGQTVH 475 Query: 501 AVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPS 560 A + TP+GH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV +G+ALVPS Sbjct: 476 AEDATPEGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVFSRGNALVPS 535 Query: 561 WVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVA 620 WVAFAV GL+EQ+FG LVDY FT+ +ED+LD+IA+G RT+WL FYFG + +SV Sbjct: 536 WVAFAVVGLMEQNFGSLVDYDFTSELEDQLDSIATGNTDRTNWLTGFYFGDANAPEESVP 595 Query: 621 RAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGEDGEPTP 679 GGLK +VG NLE IDAREVNS++LF D++GR I VRVG+ GPYLER + +DGEP Sbjct: 596 YQGGLKAIVGQNLENIDAREVNSLRLFADKEGRDIVVRVGRYGPYLERVVGLTDDGEPEF 655 Query: 680 QRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEIL-XX 738 QRANL ++ TPDELTL AE+LFATPQ GR LG +P++G +VAK+GRYGPYVTE++ Sbjct: 656 QRANLPEATTPDELTLEFAEKLFATPQSGRELGTNPDNGRTVVAKEGRYGPYVTELVRDD 715 Query: 739 XXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT------------LEDALKLLSL 786 R R + +T T +++ LK + Sbjct: 716 ERSVVEKQALEVVQKEREEEDAQRKAEGKRKKNWETKTAEKQKQKRIDEFIQEKLKPGTA 775 Query: 787 PRVVGTDPAS---------------------GEEITAQNGRYGPYLKRGTDSRSLATEDQ 825 DPA+ GE ITAQNGRYGPYLK+G+DSRSLA+ED Sbjct: 776 SLFSSMDPAAVTLEEALKLLSLPRELGADDDGEIITAQNGRYGPYLKKGSDSRSLASEDL 835 Query: 826 IFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNA 885 IF+ITLD+A IY EPKR GRQ+A PPL+ LG + SGKPMV+KDGRFGPYVTDG+TNA Sbjct: 836 IFTITLDQAKAIYREPKRRGRQAAK-PPLKTLGNNDVSGKPMVVKDGRFGPYVTDGDTNA 894 Query: 886 SLRKGDEVASITDERASELLADRRARGPVKRAAKK--TTRKSPAKKAVK 932 SL++GD ++TD RA ELL++RRAR KK T +K+ KKA K Sbjct: 895 SLKRGDTPETLTDARACELLSERRAREAAGEVGKKKTTRKKATRKKATK 943 Score = 59.3 bits (142), Expect = 2e-06 Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 27/147 (18%) Query: 797 GEEITAQNGRYGPYLKRG---TDS-------RSLATEDQIFSITLDEALKIYAEPKRSGR 846 G +I + GRYGPYL+R TD +L +TL+ A K++A P+ Sbjct: 627 GRDIVVRVGRYGPYLERVVGLTDDGEPEFQRANLPEATTPDELTLEFAEKLFATPQSG-- 684 Query: 847 QSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLA 906 RELGT+ +G+ +V K+GR+GPYVT+ L + DE S+ +++A E++ Sbjct: 685 --------RELGTNPDNGRTVVAKEGRYGPYVTE------LVRDDE-RSVVEKQALEVVQ 729 Query: 907 DRRARGPVKRAAKKTTRKSPAKKAVKR 933 R +R A+ +K+ K ++ Sbjct: 730 KEREEEDAQRKAEGKRKKNWETKTAEK 756 >tr|A8LF30|A8LF30_FRASN Tax_Id=298653 RecName: Full=DNA topoisomerase; EC=5.99.1.2; Flags: Precursor;[Frankia sp.] Length = 1023 Score = 1053 bits (2724), Expect = 0.0 Identities = 576/919 (62%), Positives = 670/919 (72%), Gaps = 46/919 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESP KA+ +AGYLGP + VESS GHIRDLPR+AADVP K +PWARLGV+VD F Sbjct: 78 LVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLPRSAADVPTAHKGKPWARLGVDVDNGF 137 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY++SP+KK VS ATD DREGEAIAWHLL+TLKP VPVKRMVFH Sbjct: 138 EPLYVVSPDKKVQVSKLKSLVKDASELYLATDEDREGEAIAWHLLQTLKPTVPVKRMVFH 197 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT AI A ++PR+++ +LV+AQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 198 EITPQAIQRAVDSPREINENLVNAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 257 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPT--FVARLTSVDGLRVATGRDF 260 TR++V+RER RM FR+A YW+I +V+ AA T A L ++DG R+A+GRDF Sbjct: 258 TRILVERERARMRFRTAEYWNIEGVFQQNVAHDGAALDTTPLPATLVALDGRRLASGRDF 317 Query: 261 DSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAG 320 G L +D V +LDEA A ALA L GA +V SVE KPY R PYPPFMTSTLQQEAG Sbjct: 318 APTGEL-TSDGVALLDEAGARALAGRLTGAAFAVRSVETKPYRRSPYPPFMTSTLQQEAG 376 Query: 321 RKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQ 380 RKLRFS +RTM +AQRLYENGYITYMRTDST LSE+A+ AAR QAR LYG EYV PR Sbjct: 377 RKLRFSSQRTMQVAQRLYENGYITYMRTDSTNLSETALVAARDQARTLYGAEYVPDRPRV 436 Query: 381 YTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTL 440 Y +KVKNAQEAHEAIRPAG+ F TP VR ELDGD FRLYELIWQRTVASQMADARGT+ Sbjct: 437 YAKKVKNAQEAHEAIRPAGDHFRTPGEVRSELDGDSFRLYELIWQRTVASQMADARGTSA 496 Query: 441 SLRIGG-SAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRL 499 ++R+G S+ + FSASG+ +TFPGFL+AYVE D+ E +D ERRLP++ G L Sbjct: 497 TIRLGATSSSGEDAEFSASGKVITFPGFLRAYVEGADD-PDAELEDRERRLPDVRRGDPL 555 Query: 500 DAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVP 559 LTP GHTT+PP R+TEASLVK EELGIGRPSTY II TIQDRGYV KKGSALVP Sbjct: 556 ATRTLTPRGHTTSPPPRFTEASLVKTLEELGIGRPSTYASIIGTIQDRGYVWKKGSALVP 615 Query: 560 SWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG----GDHGV 615 S+VAFAV GLLE HF LVDY FTA+MED+LDAIA+G TDWL FYFG D G Sbjct: 616 SFVAFAVVGLLEDHFTRLVDYQFTASMEDDLDAIAAGTAASTDWLTGFYFGLPDTTDTGG 675 Query: 616 SDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDG 675 S +V GLK LVG L IDAREVNSI L + G P+ VRVG+ GPY++ DG Sbjct: 676 SGAVE---GLKHLVGERLGEIDAREVNSIPLGKADDGEPVVVRVGRYGPYVQHA----DG 728 Query: 676 EPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEI 735 RA++ D + PDELT+ A EL A P R+LG DP++G I AK GRYGPYVT Sbjct: 729 -----RASVPDEVAPDELTVERALELLAAPSGDRLLGTDPKTGASITAKAGRYGPYVT-- 781 Query: 736 LXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPA 795 ++ SLLR+M L+T+TLEDAL+LL+LPRV+GTD A Sbjct: 782 --------------------TDSEPPQTASLLRTMSLETVTLEDALRLLTLPRVLGTD-A 820 Query: 796 SGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSG-RQSASAPPL 854 G E+TAQNGRYGPY+KRG DSRSL +EDQ+F++TLDEAL + A+PK G RQ+A PPL Sbjct: 821 EGAEVTAQNGRYGPYVKRGADSRSLESEDQLFTVTLDEALALLAQPKARGRRQAAQTPPL 880 Query: 855 RELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARG-P 913 RELG D A+ +PMV+++GRFGPYVTDGETNASLRKGD V +IT ERA+ELLADRRARG Sbjct: 881 RELGPDPATERPMVLREGRFGPYVTDGETNASLRKGDAVETITVERAAELLADRRARGTT 940 Query: 914 VKRAAKKTTRKSPAKKAVK 932 R KTT K+PAK K Sbjct: 941 TPRRTTKTTAKAPAKATAK 959 Score = 90.5 bits (223), Expect = 1e-15 Identities = 68/224 (30%), Positives = 106/224 (47%), Gaps = 45/224 (20%) Query: 716 ESGHEIVAKDGRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTI 775 + G +V + GRYGPYV S+ + + Sbjct: 707 DDGEPVVVRVGRYGPYVQHA-------------------------DGRASVPDEVAPDEL 741 Query: 776 TLEDALKLLSLP---RVVGTDPASGEEITAQNGRYGPYLKRGTD---SRSLATEDQIFSI 829 T+E AL+LL+ P R++GTDP +G ITA+ GRYGPY+ ++ + SL + ++ Sbjct: 742 TVERALELLAAPSGDRLLGTDPKTGASITAKAGRYGPYVTTDSEPPQTASLLRTMSLETV 801 Query: 830 TLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRK 889 TL++AL++ P R LGTDA G + ++GR+GPYV G + SL Sbjct: 802 TLEDALRLLTLP-------------RVLGTDA-EGAEVTAQNGRYGPYVKRGADSRSLES 847 Query: 890 GDEVASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 D++ ++T + A LLA +ARG + A R+ A +R Sbjct: 848 EDQLFTVTLDEALALLAQPKARGRRQAAQTPPLRELGPDPATER 891 Score = 62.4 bits (150), Expect = 3e-07 Identities = 51/158 (32%), Positives = 73/158 (46%), Gaps = 16/158 (10%) Query: 779 DALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIY 838 DA ++ S+P D GE + + GRYGPY++ S+ E +T++ AL++ Sbjct: 694 DAREVNSIPLGKADD---GEPVVVRVGRYGPYVQHADGRASVPDEVAPDELTVERALELL 750 Query: 839 AEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYV-TDGE--TNASLRKGDEVAS 895 A P R LGTD +G + K GR+GPYV TD E ASL + + + Sbjct: 751 AAPSGD----------RLLGTDPKTGASITAKAGRYGPYVTTDSEPPQTASLLRTMSLET 800 Query: 896 ITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKR 933 +T E A LL R G A+ T + VKR Sbjct: 801 VTLEDALRLLTLPRVLGTDAEGAEVTAQNGRYGPYVKR 838 >tr|C5V9G5|C5V9G5_9CORY Tax_Id=553207 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium matruchotii ATCC 14266] Length = 986 Score = 1053 bits (2723), Expect = 0.0 Identities = 564/968 (58%), Positives = 689/968 (71%), Gaps = 64/968 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+A YLG YIVE+S GHIRDLPR AADVP K+K EPWARLGVNVD +F Sbjct: 10 LVIVESTTKAKKIAPYLGSNYIVEASVGHIRDLPRGAADVPPKYKKEPWARLGVNVDKNF 69 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLL+TLKP+VPV+RMVFH Sbjct: 70 TPLYVVSPDKKKKVADLKAKLKDVDELLLATDPDREGEAIAWHLLQTLKPKVPVRRMVFH 129 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAIL AA+N R+LD +LVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 130 EITKPAILAAAQNTRELDNNLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 189 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPT-----------FVARLTSVDG 251 TR+IV RER+RM F A YWD+ A A S A+ + F RL+ V+G Sbjct: 190 TRVIVDRERNRMVFVPAEYWDLAAEFTAPASAGTASQGSSTSTDGGDDRKFTGRLSRVNG 249 Query: 252 LRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFM 311 RVA GRDF+ G L + V+ +A+A LAT L L V +VEEKPY+R+P PFM Sbjct: 250 KRVAAGRDFNDRGEL--TSDAVVVTKAQAEQLATQLQHVTLPVINVEEKPYTRKPSAPFM 307 Query: 312 TSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGE 371 TSTLQQEAGRKL ++ ERTM +AQRLYENG+ITYMRTDSTTLSE + AAR QA L+G+ Sbjct: 308 TSTLQQEAGRKLHYTSERTMRVAQRLYENGHITYMRTDSTTLSEQGLQAARQQAIALFGK 367 Query: 372 EYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQ 431 ++VA SPR+Y RKVKN+QEAHEAIRPAGE F+TP +R +LD +E++LYELIWQRT+ASQ Sbjct: 368 DHVADSPRRYDRKVKNSQEAHEAIRPAGEQFSTPAELRSQLDAEEYKLYELIWQRTIASQ 427 Query: 432 MADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLP 491 MAD +G ++ + I G + V F+ +GRT+TF GFL+AY + + + +D + RLP Sbjct: 428 MADVKGVSMKVTI----GNEDVEFTTTGRTVTFAGFLRAYSDAIAD-AAASSDANQSRLP 482 Query: 492 NLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVH 551 +L G + ++ D HTTNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV+ Sbjct: 483 HLKVGDEVAISDVAADEHTTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVY 542 Query: 552 KKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGG 611 +G+ALVPSWVAFAV GL+E+ F LVDY FT++MEDELD IA+G E +WL FYFG Sbjct: 543 SRGNALVPSWVAFAVVGLMEKSFAALVDYDFTSSMEDELDDIAAGNEVGANWLKGFYFGD 602 Query: 612 DH---GVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLER 668 H ++++AR GGLK LVG NLE IDAR VNS+ LFDD+QGRPIYVRVG+ GPYLER Sbjct: 603 KHASDATAETIARQGGLKALVGNNLEQIDARVVNSLPLFDDDQGRPIYVRVGRYGPYLER 662 Query: 669 TI-TGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGR 727 I DGEP QRANL+D+ TPDELTL AE+LFATPQ GR LG++P +G IV K+GR Sbjct: 663 QIGVKPDGEPEFQRANLSDTTTPDELTLEFAEKLFATPQSGRELGVNPANGRVIVVKEGR 722 Query: 728 YGPYVTEIL-XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT---------- 776 +GPYVTEI+ R+ R+ + +T T Sbjct: 723 FGPYVTEIMGADEKEKVAVSAEQIVAEERAAEDAQRAAEGKRAKNWETKTAIAAKEKRIN 782 Query: 777 --LEDALK----------------------LLSLPRVVGTDPASGEEITAQNGRYGPYLK 812 +E+ LK L+SLPR VG DP G+ ITAQNGRYGPYLK Sbjct: 783 QIIEETLKPATASLFSSMDPSTVTLEEALQLISLPREVGVDPTDGQMITAQNGRYGPYLK 842 Query: 813 RGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDG 872 +GTDSRSL++E+QIF+ITLDEA +IYAEPKR GR +A+ ++ELG + SGKPM +KDG Sbjct: 843 KGTDSRSLSSEEQIFTITLDEARRIYAEPKRRGRGAATQQAIKELGDNDVSGKPMSVKDG 902 Query: 873 RFGPYVTDGETNASLRKGDEVASITDERASELLADRRAR-----GPVKRAAKKTT--RKS 925 RFGPYVTDGETNASLRKGD+ ++TD RA+ELL++RRA+ GP K+A KKT +K+ Sbjct: 903 RFGPYVTDGETNASLRKGDDPLTLTDARANELLSERRAKEAADGGPKKKATKKTAAKKKT 962 Query: 926 PAKKAVKR 933 KKAVK+ Sbjct: 963 TTKKAVKK 970 >tr|C0E5R1|C0E5R1_9CORY Tax_Id=566549 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium matruchotii ATCC 33806] Length = 986 Score = 1051 bits (2718), Expect = 0.0 Identities = 563/968 (58%), Positives = 690/968 (71%), Gaps = 64/968 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+A YLG YIVE+S GHIRDLPR AADVP K+K EPWARLGVNVD +F Sbjct: 10 LVIVESTTKAKKIAPYLGSNYIVEASVGHIRDLPRGAADVPPKYKKEPWARLGVNVDKNF 69 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLL+TLKP+VPV+RMVFH Sbjct: 70 TPLYVVSPDKKKKVADLKAKLKDVDELLLATDPDREGEAIAWHLLQTLKPKVPVRRMVFH 129 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+PAIL AA+N R+LD +LVDAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 130 EITKPAILAAAQNTRELDNNLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 189 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVS---DPKAAPPT--------FVARLTSVDG 251 TR+IV RER+RM F A YWD+ A A S P+ + + F RL+ V+G Sbjct: 190 TRVIVDRERNRMVFVPAEYWDLAAEFTAPASAGTAPRGSSTSTDGGDDRKFTGRLSRVNG 249 Query: 252 LRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFM 311 RVA GRDF+ G L + V+ +A+A LAT L L V +VEEKPY+R+P PFM Sbjct: 250 KRVAAGRDFNDRGEL--TSDAVVVTKAQAEQLATKLQHVTLPVINVEEKPYTRKPSAPFM 307 Query: 312 TSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGE 371 TSTLQQEAGRKL ++ ERTM +AQRLYENG+ITYMRTDSTTLSE + AAR QA L+G+ Sbjct: 308 TSTLQQEAGRKLHYTSERTMRVAQRLYENGHITYMRTDSTTLSEQGLQAARQQAIALFGK 367 Query: 372 EYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQ 431 ++VA +PR+Y RKVKN+QEAHEAIRPAGE F+TP +R +LD +E++LYELIWQRT+ASQ Sbjct: 368 DHVADAPRRYDRKVKNSQEAHEAIRPAGEQFSTPAELRSQLDAEEYKLYELIWQRTIASQ 427 Query: 432 MADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLP 491 MAD +G ++ + I G + V F+ +GRT+TF GFL+AY + + + +D + RLP Sbjct: 428 MADVKGVSMKVTI----GNEDVEFTTTGRTVTFAGFLRAYSDAIAD-AAASSDANQSRLP 482 Query: 492 NLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVH 551 +L G + ++ D HTTNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV+ Sbjct: 483 HLKVGDEVAISDVAADEHTTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVY 542 Query: 552 KKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGG 611 +G+ALVPSWVAFAV GL+E+ F LVDY FT++MEDELD IA+G E +WL FYFG Sbjct: 543 SRGNALVPSWVAFAVVGLMEKSFAALVDYDFTSSMEDELDDIAAGNEVGANWLKGFYFGD 602 Query: 612 DH---GVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLER 668 H ++++AR GGLK LVG NLE IDAR VNS+ LFDD+QGRPIYVRVG+ GPYLER Sbjct: 603 KHASDATAETIARQGGLKALVGNNLEQIDARVVNSLPLFDDDQGRPIYVRVGRYGPYLER 662 Query: 669 TI-TGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGR 727 I DGEP QRANL+D+ TPDELTL AE+LFATPQ GR LG++P +G IVAK+GR Sbjct: 663 QIGVKPDGEPEFQRANLSDTTTPDELTLEFAEKLFATPQSGRELGVNPANGRVIVAKEGR 722 Query: 728 YGPYVTEIL-XXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTIT---------- 776 +GPYVTEI+ R+ R+ + +T T Sbjct: 723 FGPYVTEIMGADEKEKVAVSAEQIVAEERAAEDAQRAAEGKRAKNWETKTAIAAKEKRIN 782 Query: 777 --LEDALK----------------------LLSLPRVVGTDPASGEEITAQNGRYGPYLK 812 +E+ LK L+SLPR VG DP G+ ITAQNGRYGPYLK Sbjct: 783 QIIEETLKPATASLFSSMDPSTVTLEEALQLISLPREVGVDPTDGQMITAQNGRYGPYLK 842 Query: 813 RGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDG 872 +GTDSRSL++E+QIF+ITLDEA +IYAEPKR GR + + ++ELG + SGKPM +KDG Sbjct: 843 KGTDSRSLSSEEQIFTITLDEARRIYAEPKRRGRGATTQQAIKELGDNDVSGKPMSVKDG 902 Query: 873 RFGPYVTDGETNASLRKGDEVASITDERASELLADRRAR-----GPVKRAAKKTT--RKS 925 RFGPYVTDGETNASLRKGD+ ++TD RA+ELL++RRA+ GP K+A KKT +K+ Sbjct: 903 RFGPYVTDGETNASLRKGDDPLTLTDARANELLSERRAKEAADGGPKKKATKKTAAKKKT 962 Query: 926 PAKKAVKR 933 KKAVK+ Sbjct: 963 TTKKAVKK 970 >tr|Q0RBI4|Q0RBI4_FRAAA Tax_Id=326424 (topA)RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Frankia alni] Length = 1036 Score = 1046 bits (2704), Expect = 0.0 Identities = 574/926 (61%), Positives = 666/926 (71%), Gaps = 56/926 (6%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVESP KA+ +AGYLGP + VESS GHIRDLPR+AADVPA K +PWARLGV+VD DF Sbjct: 47 LVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLPRSAADVPAAHKGKPWARLGVDVDNDF 106 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 EPLY+++P+KK VS ATD DREGEAIAWHLL+TLKP VPVKRMVFH Sbjct: 107 EPLYVVTPDKKLQVSKLKALVKEASELYLATDEDREGEAIAWHLLQTLKPTVPVKRMVFH 166 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT AI A +NPR++D +LV+AQETRRILDRLYGYEVSPVLWKKV PKLSAGRVQSVA Sbjct: 167 EITPQAIRRAVDNPREIDENLVNAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVA 226 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASV--------SDPKAAPPT--------FVARL 246 TR++V+RER RM FR+A YW+I A+V +D A T A L Sbjct: 227 TRVLVERERARMRFRAAEYWNIEGLFGATVARQAWPAGTDGADADATGGGVERTPLPATL 286 Query: 247 TSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRP 306 ++DG R+ATGRDF G L + VT LDEA A AL L A +V SVE KPY R P Sbjct: 287 VALDGNRIATGRDFAPTGELTTSG-VTRLDEAGARALTDRLAQAAFAVRSVETKPYRRSP 345 Query: 307 YPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQAR 366 YPPFMTSTLQQEAGRKLRFS +RTM IAQRLYENGYITYMRTDST LSE+A+ AAR+QA Sbjct: 346 YPPFMTSTLQQEAGRKLRFSSQRTMQIAQRLYENGYITYMRTDSTNLSETALAAARSQAE 405 Query: 367 QLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQR 426 LYG EYV +SPR YT+KVKNAQEAHEAIRPAG+ F TP VR ELD D +RLYELIWQR Sbjct: 406 SLYGPEYVPASPRTYTKKVKNAQEAHEAIRPAGDHFRTPGEVRGELDVDSYRLYELIWQR 465 Query: 427 TVASQMADARGTTLSLRIGG-SAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADD 485 TVASQMADARGT+ ++R+G S+ + FSASG+ +TFPGFL+AYVE D+ E +D Sbjct: 466 TVASQMADARGTSATIRLGATSSTGEDAEFSASGKVITFPGFLRAYVEGADD-PDAELED 524 Query: 486 AERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQ 545 ERRLP++ G L LTP GHTT+PPAR+TEASLVK EELGIGRPSTY II TIQ Sbjct: 525 RERRLPDVRQGDPLAVRSLTPRGHTTSPPARFTEASLVKTLEELGIGRPSTYASIIGTIQ 584 Query: 546 DRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLN 605 DRGYV KKGSALVPS+VAFAV GLLE HFG LVDY FTA MED+LD IA+G TDWL Sbjct: 585 DRGYVWKKGSALVPSFVAFAVVGLLEDHFGRLVDYRFTATMEDDLDDIAAGTSASTDWLT 644 Query: 606 NFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPY 665 FYFG G A A GLK LV L IDAREVNSI L + G + VRVG+ GPY Sbjct: 645 RFYFGTGDGTDP--ATAAGLKHLVSERLGEIDAREVNSIPLGKADDGTTVVVRVGRYGPY 702 Query: 666 LERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKD 725 ++ GE RA++ D L PDELT+ A EL A P RVLG+D +G I AK Sbjct: 703 VQ---LGEG------RASVPDDLAPDELTVARALELLAAPSGDRVLGVDAATGATITAKA 753 Query: 726 GRYGPYVTEILXXXXXXXXXXXXXXXXXXXXXXXXXRSGSLLRSMDLQTITLEDALKLLS 785 GR+GPYVT R+ SLLR+M L+T+TL+DA+KLL+ Sbjct: 754 GRFGPYVT----------------------TDTDPPRTSSLLRTMSLETLTLDDAVKLLT 791 Query: 786 LPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSG 845 LPR +G A GEE+TAQNGRYGPY+K+G +SRSL +EDQ+F++TL+EAL + A+PK G Sbjct: 792 LPRTLGAG-ADGEEVTAQNGRYGPYVKKGAESRSLESEDQLFTVTLEEALALLAQPKARG 850 Query: 846 -RQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASEL 904 RQ+A PPLRELG D ASGKPMV+++GRFGPYVTDGETNASLRKGD V SITD RA+EL Sbjct: 851 RRQAAQTPPLRELGNDPASGKPMVVREGRFGPYVTDGETNASLRKGDAVESITDARAAEL 910 Query: 905 LADRRARG--PVKRAAKKTTRKSPAK 928 LADRRARG P KRAA+ T + + K Sbjct: 911 LADRRARGPAPAKRAARGTAKTTATK 936 >tr|C2BKM3|C2BKM3_9CORY Tax_Id=525264 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium pseudogenitalium ATCC 33035] Length = 991 Score = 1045 bits (2702), Expect = 0.0 Identities = 559/961 (58%), Positives = 695/961 (72%), Gaps = 56/961 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+ YLG YIVE+S GHIRDLPR AADVPAK+K E WARLGVN + DF Sbjct: 11 LVIVESATKAKKIQPYLGDNYIVEASVGHIRDLPRGAADVPAKYKKESWARLGVNPEDDF 70 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 71 APLYVVSPDKKKKVADLKSKLKQCDQLYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFN 130 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+ AILEAA+N RDLD +L+DAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 131 EITKSAILEAADNTRDLDYNLIDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 190 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RMAF SA YWD+ ATLD +D P TF ARLT+V+ RVA GRDFD Sbjct: 191 TRVIVERERERMAFISADYWDLAATLDTGAADAD-NPATFDARLTAVNSKRVALGRDFDD 249 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G + K+ +V V+ E +A AL T L GA + VA VE KPY+R+PY PFMTSTLQQEAGR+ Sbjct: 250 RGNV-KSKDVIVITEPQAKALETALRGADMQVAGVEHKPYTRKPYAPFMTSTLQQEAGRR 308 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 L F+ ERTM IAQRLYENG+ITYMRTDST+LS+ ++AAR A +YG EYV+ SPR Y Sbjct: 309 LHFTSERTMRIAQRLYENGHITYMRTDSTSLSKQGLSAARNSATSIYGAEYVSDSPRVYD 368 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKN+QEAHEAIRPAGE+FATP + +LD +EF+LY+LIW+RTVASQMADA+GT++ + Sbjct: 369 RKVKNSQEAHEAIRPAGESFATPGQLSGQLDAEEFKLYDLIWKRTVASQMADAKGTSMKV 428 Query: 443 RIGGSA----GEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQR 498 + G+A G V FSA+GRT+TFPGFLKAY D+ G + E RLP+L G+ Sbjct: 429 TVAGTAATDKGSYDVEFSATGRTITFPGFLKAY--GADDAKGDK--KGETRLPHLEEGRA 484 Query: 499 LDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALV 558 L A E++ +GH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV +G+ALV Sbjct: 485 LTAKEVSAEGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVVSRGNALV 544 Query: 559 PSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG---GDHGV 615 PSWVAFAV GLLE++F LVDY FT++MEDELD IA+G E T WLN FYFG + Sbjct: 545 PSWVAFAVVGLLEENFTELVDYDFTSSMEDELDQIATGIEDGTAWLNGFYFGNAEANEQK 604 Query: 616 SDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGED 674 + S+AR GGLK L+ VNLE IDAR+VNS++L+ D +GR ++VRVG+ GPY+ER + T +D Sbjct: 605 AASIARHGGLKSLIDVNLEAIDARKVNSLRLYTDTEGRDVFVRVGRYGPYIERAVGTNDD 664 Query: 675 GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTE 734 G QRANL++++TPD L LAE+LFATPQ GR LG +PE+G IVAK+GR+GPYVTE Sbjct: 665 GSIEYQRANLSETVTPDGLNEELAEKLFATPQGGRELGENPENGRMIVAKEGRFGPYVTE 724 Query: 735 ILXXXXXXXXXXXXXXXXXXXXXXXXXR---SGSLLRSMDLQTIT----------LEDAL 781 ++ + G ++ + +T +E+ L Sbjct: 725 VVREDEREKAEGEAEEIVAKERAEEDKQRAEEGKRAKNWETKTAAKQKEKRVKEYIENKL 784 Query: 782 KLLSLPRVVGTDPAS----------------GEE----ITAQNGRYGPYLKRGTDSRSLA 821 K + +P++ GE+ ITAQNGRYGPYLK+GTDSRSLA Sbjct: 785 KPGTASLFSSMEPSTVTLEEALKLLSLPREVGEDDGVMITAQNGRYGPYLKKGTDSRSLA 844 Query: 822 TEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDG 881 E+QIF++TLDEA +IYAEPKR GR +A+ PP+++LG + SGKPM +KDGRFGPYVTDG Sbjct: 845 KEEQIFTVTLDEARRIYAEPKRRGR-AAAQPPIKQLGDNDVSGKPMTVKDGRFGPYVTDG 903 Query: 882 ETNASLRKGDEVASITDERASELLADRRA--------RGPVKRAAKKTTRKSPAKKAVKR 933 TNASLR+GD+ +TD RA+ELL++RRA + K+++KKTT+K KKA K+ Sbjct: 904 TTNASLRRGDDPEQLTDARANELLSERRAKEASGETKKKSTKKSSKKTTKKKATKKATKK 963 Query: 934 A 934 + Sbjct: 964 S 964 >tr|C6R7P2|C6R7P2_9CORY Tax_Id=553206 RecName: Full=DNA topoisomerase; EC=5.99.1.2;[Corynebacterium tuberculostearicum SK141] Length = 991 Score = 1043 bits (2698), Expect = 0.0 Identities = 559/961 (58%), Positives = 694/961 (72%), Gaps = 56/961 (5%) Query: 23 LVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADF 82 LVIVES TKA+K+ YLG YIVE+S GHIRDLPR AADVPAK+K E WARLGVN + DF Sbjct: 11 LVIVESATKAKKIQPYLGDNYIVEASVGHIRDLPRGAADVPAKYKKESWARLGVNPEDDF 70 Query: 83 EPLYIISPEKKSAVSXXXXXXXXXXXXXXATDGDREGEAIAWHLLETLKPRVPVKRMVFH 142 PLY++SP+KK V+ ATD DREGEAIAWHLLE LKP+VPV+RMVF+ Sbjct: 71 APLYVVSPDKKKKVADLKSKLKQCDQLYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFN 130 Query: 143 EITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVA 202 EIT+ AILEAA+N RDLD +L+DAQETRRILDRLYGYEVSPVLWKKV P+LSAGRVQSVA Sbjct: 131 EITKSAILEAADNTRDLDYNLIDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVA 190 Query: 203 TRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDS 262 TR+IV+RER+RMAF A YWD+ ATLD +D P TF ARLT+V+ RVA GRDFD Sbjct: 191 TRVIVERERERMAFIPADYWDLAATLDTGAADAD-NPATFDARLTAVNSKRVALGRDFDD 249 Query: 263 LGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRK 322 G + K+ +V V+ E +A AL T L GA + VA VE KPY+R+PY PFMTSTLQQEAGR+ Sbjct: 250 RGNV-KSKDVIVITEPQAKALETALRGADMQVAGVEHKPYTRKPYAPFMTSTLQQEAGRR 308 Query: 323 LRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYT 382 L F+ ERTM IAQRLYENG+ITYMRTDST+LS+ ++AAR A +YG EYV+ SPR Y Sbjct: 309 LHFTSERTMRIAQRLYENGHITYMRTDSTSLSQQGLSAARNSATSIYGAEYVSDSPRVYD 368 Query: 383 RKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSL 442 RKVKN+QEAHEAIRPAGE+FATP + +LD +EF+LY+LIW+RTVASQMADA+GT++ + Sbjct: 369 RKVKNSQEAHEAIRPAGESFATPGQLSGQLDAEEFKLYDLIWKRTVASQMADAKGTSMKV 428 Query: 443 RIGGSA----GEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQR 498 + G+A G V FSA+GRT+TFPGFLKAY D+ G + E RLP+L G+ Sbjct: 429 TVAGTAATDKGSYDVEFSATGRTITFPGFLKAY--GADDAKGDK--KGETRLPHLEEGRG 484 Query: 499 LDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALV 558 L A E++ +GH+TNPPARYTEASLVK E+LGIGRPSTY IIKTIQDRGYV +G+ALV Sbjct: 485 LTAKEVSAEGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVVSRGNALV 544 Query: 559 PSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFG---GDHGV 615 PSWVAFAV GLLE++F LVDY FT++MEDELD IA+G E T WLN FYFG + Sbjct: 545 PSWVAFAVVGLLEENFTELVDYDFTSSMEDELDQIATGIEDGTAWLNGFYFGNAEANEQK 604 Query: 616 SDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTI-TGED 674 + S+AR GGLK L+ VNLE IDAR+VNS++L+ D +GR ++VRVG+ GPY+ER + T +D Sbjct: 605 AASIARHGGLKSLIDVNLEAIDARKVNSLRLYTDTEGRDVFVRVGRYGPYIERAVGTNDD 664 Query: 675 GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTE 734 G QRANL++++TPD L LAE+LFATPQ GR LG +PE+G IVAK+GR+GPYVTE Sbjct: 665 GSIEYQRANLSETVTPDGLNEELAEKLFATPQGGRELGENPENGRMIVAKEGRFGPYVTE 724 Query: 735 ILXXXXXXXXXXXXXXXXXXXXXXXXXR---SGSLLRSMDLQTIT----------LEDAL 781 ++ + G ++ + +T +E+ L Sbjct: 725 VVREDEREKAEGEAEEVVAKERAEEDKQRAEEGKRAKNWETKTAAKQKEKRVKEYIENKL 784 Query: 782 KLLSLPRVVGTDPAS----------------GEE----ITAQNGRYGPYLKRGTDSRSLA 821 K + +P++ GE+ ITAQNGRYGPYLK+GTDSRSLA Sbjct: 785 KPGTASLFSSMEPSTVTLEEALKLLSLPREVGEDDGVMITAQNGRYGPYLKKGTDSRSLA 844 Query: 822 TEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDG 881 E+QIF+ITLDEA +IYAEPKR GR +A+ PP+++LG + SGKPM +KDGRFGPYVTDG Sbjct: 845 KEEQIFTITLDEARRIYAEPKRRGR-AAAQPPIKQLGDNDVSGKPMTVKDGRFGPYVTDG 903 Query: 882 ETNASLRKGDEVASITDERASELLADRRA--------RGPVKRAAKKTTRKSPAKKAVKR 933 TNASLR+GD+ +TD RA+ELL++RRA + K+++KKTT+K KKA K+ Sbjct: 904 TTNASLRRGDDPEQLTDARANELLSERRAKEASGETKKKSTKKSSKKTTKKKATKKATKK 963 Query: 934 A 934 + Sbjct: 964 S 964 Database: Amellifera_nr Posted date: Feb 5, 2010 5:10 AM Number of letters in database: 3,846,993,858 Number of sequences in database: 11,275,203 Lambda K H 0.315 0.132 0.375 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 11275203 Number of Hits to DB: 6,546,296,858 Number of extensions: 276390139 Number of successful extensions: 554003 Number of sequences better than 10.0: 4107 Number of HSP's gapped: 535924 Number of HSP's successfully gapped: 6765 Length of query: 934 Length of database: 3,846,993,858 Length adjustment: 147 Effective length of query: 787 Effective length of database: 2,189,539,017 Effective search space: 1723167206379 Effective search space used: 1723167206379 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 85 (37.4 bits)