Gene ML0578
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in the Tricarboxylic acid cycle, through THE CARBOXYLATION OF PHOSPHOENOLPYRUVATE (PEP) IT FORMS OXALOACETATE, A FOUR-CARBON DICARBOXYLIC ACID SOURCE FOR THE TRICARBOXYLIC ACID CYCLE [CATALYTIC ACTIVITY : PHOSPHATE + OXALOACETATE = H(2)O + PHOSPHOENOLPYRUVATE + CO(2] |
| Product | Probable phosphoenolpyruvate carboxylase Ppc |
| Comments | ML0578, len: 934 aa. Probable ppc, phosphoenolpyruvate carboxylase (EC 4.1.1.31), similar to many e.g. CAPP_RHOPA|O32483 ppc, phosphoenolpyruvate carboxylase from Rhodopseudomonas palustris (936 aa), Fasta scores: E(): 5.6e-160, (45.7% identity in 936 aa overlap). Previously sequenced as CAPP_MYCLE|P46710 (907 aa), Fasta scores: E(): 0, (100.0% identity in 907 aa overlap). Contains 2 Pfam matches to entry PF00311 PEPCase, Phosphoenolpyruvate carboxylase. Contains PS00781 Phosphoenolpyruvate carboxylase active site 1. Contains PS00393 Phosphoenolpyruvate carboxylase active site 2. Belongs to the PEPCase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 700215 | 703019 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0578|ppc
MVEFSDAILEPIGAVQRTRVGREATEPMRADIRLLGTILGDTLREQNGDEVFDLVERVRVESFRVRRSEIDRADMARMFSGLDIHLAIPIIRAFSHFALLANVAEDIHRERRRHIHLDAGEPLRDSSLAATYAKLDLAKLDSATVADALTGAVVSPVITAHPTETRRRTVFVTQRRITELMRLHAEGHTETADGRSIERELRRQILTLWQTALIRLARLQISDEIDVGLRYYSAALFHVIPQVNSEVRNALRARWPDAELLSGPILQPGSWIGGDRDGNPNVTADVVRRATGSAAYTVVAHYLAELTHLEQELSMSARLITVTPELATLAASCQDAACADEPYRRALRVIRGRLSSTAAHILDQQPPNQLGLGLPPYSTPAELCADLDTIEASLCTHGAALLADDRLALLREGVGVFGFHLCGLDMRQNSDVHEEVVAELLAWAGMHQDYSSLPEDQRVKLLVAELGNRRPLVGDRAQLSDLARGELAVLAAAAHAVELYGSAAVPNYIISMCQSVSDVLEVAILLKETGLLDASGSQPYCPVGISPLFETIDDLHNGAAILHAMLELPLYRTLVAARGNWQEVMLGYSDSNKDGGYLAANWAVYRAELALVDVARKTGIRLRLFHGRGGTVGRGGGPSYQAILAQPPGAVNGSLRLTEQGEVIAAKYAEPQIARRNLESLVAATLESTLLDVEGLGDAAESAYAILDEVAGLARRSYAELVNTPGFVDYFQASTPVSEIGSLNIGNRPTSRKPTTSIADLRAIPWVLAWSQSRVMLPGWYGTGSAFQQWVAAGPESESQRVEMLHDLYQRWPFFRSVLSNMAQVLAKSDLGLAARYAELVVDEALRRRVFDKIADEHRRTIAIHKLITGHDDLLADNPALARSVFNRFPYLEPLNHLQVELLRRYRSGHDDEMVQRGILLTMNGLASALRNSG
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