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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown (possibly involved in transport across the membrane).
ProductProbable conserved integral membrane protein
CommentsRv2395, (MTCY253.26c), len: 667 aa. Probable conserved integral membrane protein, similar to AAK24613|CC2646 oligopeptide transporter/opt family protein from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 putative integral membrane protein from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap). Rv2395, (MTCY253.26c), len: 667 aa. Probable conserved integral membrane protein, similar to AAK24613|CC2646 oligopeptide transporter/opt family protein from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 putative integral membrane protein from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap).
Functional categoryCell wall and cell processes
ProteomicsIdentified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010).
MutationNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26900722692075+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
      
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2395|Rv2395
MSGATVGAREITIRGVVLGALITLVFTAANVYLGLRVGLTFATSIPAAVISMGVLRLFANHSVVENNIVQTIASAAGTLSSIIFVLPALLMIGWWSGFPYWTTAAVCALGGILGVMYSIPLRRALVTGSDLPYPEGVAGAEVLKIGDSAREMEHNRRGIGVIALGAAAAAGYALLASLRVINNSLSATFRVGSGATMIGASLSLALIGVGHLVGVTVGVAMIVGLAIAFGVMLPIRTAGQLPPDGDYAVAVARIFSTDVRFIGAGAIAVAAAWTFLKILGPILRGIADAAVSARTRRRGQAVGQTERDIPIHIVAMVVLLSLIPIGWLLADFTDGTPLDDRRPGAIAAGVLLVLVIGLMVAAVCGYMAGLIGSSNSPISGVGILVVVLAGLLIKTAYGPATGSQIPALVAYTVFTAALVFGVATISNDNLQDLKTGQLVGATPWKQQVALIIGVLVGSVVMAPILQLMQAGFGFQGAPGATANALAAPQAALMSALAKGVFGGSLNWSLVGVGALTGVIAVALDETLAKTTTNLRLPPLAVGMGMYLSAALTLMIPIGAFLGRIYDSWARWSGDDDERKKRLGVMLATGLIVGESLYGVLFAVIVATTGKEEPLAMVGDGFRFASQPLGAIVFAGLLAWLYQRTRVTASYRLAAPAGSSKPLPDLPG