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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionInvolved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). Responsible for the translocation of the substrate across the membrane.
ProductProbable sulfate-transport integral membrane protein ABC transporter CysT
CommentsRv2399c, (MTCY253.22), len: 283 aa. Probable cysT, sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. BAB48989|MLR1667 permease protein of sulfate ABC transporter from Rhizobium loti (283 aa), FASTA scores: opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa overlap); Q9K878|cyst|BH3128 sulfate ABC transporter (permease) from Bacillus halodurans (279 aa), FASTA scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa overlap); P16701|CYST_ECOLI|CYSU|cyst|B2424 from Escherichia coli (277 aa), FASTA scores: opt: 669, E(): 1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature, and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the CYSTW subfamily. Rv2399c, (MTCY253.22), len: 283 aa. Probable cysT, sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. BAB48989|MLR1667 permease protein of sulfate ABC transporter from Rhizobium loti (283 aa), FASTA scores: opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa overlap); Q9K878|cyst|BH3128 sulfate ABC transporter (permease) from Bacillus halodurans (279 aa), FASTA scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa overlap); P16701|CYST_ECOLI|CYSU|cyst|B2424 from Escherichia coli (277 aa), FASTA scores: opt: 669, E(): 1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature, and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the CYSTW subfamily.
Functional categoryCell wall and cell processes
Proteomics
MutationDisruption of this gene results in growth defect of H37Rv in vitro, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26957962696647-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
      
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2399c|cysT
MTESLVGERRAPQFRARLSGPAGPPSVRVGMAVVWLSVIVLLPLAAIVWQAAGGGWRAFWLAVSSHAAMESFRVTLTISTAVTVINLVFGLLIAWVLVRDDFAGKRIVDAIIDLPFALPTIVASLVMLALYGNNSPVGLHFQHTATGVGVALAFVTLPFVVRAVQPVLLEIDRETEEAAASLGANGAKIFTSVVLPSLTPALLSGAGLAFSRAIGEFGSVVLIGGAVPGKTEVSSQWIRTLIENDDRTGAAAISVVLLSISFIVLLILRVVGARAAKREEMAA