Refseq_ID Mycobrowser_Version Feature Start Stop Score Strand Frame Locus Name Function Product Comments UniProt_AC Is_Pseudogene Functional_Category Orthologues M. leprae Orthologues M. marinum Orthologues M. smegmatis Orthologues M. tuberculosis NC_002945.3 Mycobrowser_v2 CDS 4288594 4288896 . + 0 Mb3904 esxB 10 kda culture filtrate antigen esxb (lhp) (cfp10) Mb3904, esxB, len: 100 aa. Equivalent to Rv3874,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). esxB (alternate gene name: cfp10), 10 KDA culture filtrate antigen (see citations below, especially first), highly similar to O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA CULTURE FILTRATE ANTIGEN CFP10 HOMOLOG from Mycobacterium leprae (99 aa), FASTA scores: opt: 237, E(): 2.4e-08, (39.4% identity in 99 aa overlap). Also similar to O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 PUTATIVE ESAT-6 LIKE PROTEIN 13 from Mycobacterium tuberculosis (103 aa) FASTA scores: opt: 126, E(): 0.18, (23.1% identity in 91 aa overlap); and shows some similarity with other proteins from Mycobacterium tuberculosis. Contains probable coiled-coil from aa 49-93. BELONGS TO THE ESAT6 FAMILY. X2BQ42,P0A567 No cell wall and cell processes Rv3874 NC_002945.3 Mycobrowser_v2 CDS 4296908 4298290 . - 0 Mb3911c espb secreted esx-1 substrate protein b, espb. conserved alanine and glycine rich protein Mb3911c, -, len: 460 aa. Equivalent to Rv3881c,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 460 aa overlap). Conserved hypothetical ala-, gly-rich protein. C-terminal end highly similar to O06126 HYPOTHETICAL 9.5 KDA PROTEIN (FRAGMENT) from Mycobacterium tuberculosis strain NTI 64719 (90 aa) FASTA scores: opt: 333, E(): 6.3e-07, (69.75% identity in 86 aa overlap) but sequence difference causes frameshift in NTI 64719. Also similar to part of small Mycobacterium leprae ORF O33078|MLCB628.06 (EMBL:Y14967) (101 aa), FASTA scores: opt: 194, E(): 0.04, (59.3% identity in 54 aa overlap), suggesting this is represented by a pseudogene in M. leprae. Q7TVB3 No cell wall and cell processes Rv3881c NC_002945.3 Mycobrowser_v2 CDS 4288929 4289216 . + 0 Mb3905 esxA 6 kda early secretory antigenic target esxa (esat-6) Mb3905, esxA, len: 95 aa. Equivalent to Rv3875,len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 95 aa overlap). esxA, Early Secretory Antigenic Target (see citations below), identical to Q57165|O84901|ESAT6 EARLY SECRETORY ANTIGENIC TARGET from Mycobacterium bovis (94 aa), FASTA scores: opt: 596, E(): 4.6e-33, (100.0% identity in 94 aa overlap). Also similar to Q50206|ESA6_MYCLE|ESAT6|ESX|L45|ML0049|MLCB628.12c 6 KDA EARLY SECRETORY ANTIGENIC TARGET HOMOLOG (ESAT-6-LIKE PROTEIN) (L-ESAT) from Mycobacterium leprae (95 aa), FASTA scores: opt: 236, E(): 3.3e-09, (36.25% identity in 91 aa overlap); and weak similarity with others proteins ESAT-like from Mycobacterium leprae. Also some similarity with O53266|ES69_MYCTU|Rv3019c|MT3104|MTV012.33c PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 131, E(): 0.03,(26.15% identity in 88 aa overlap); and other ESAT-like protein. Contains probable coiled-coil from 56 to 92 aa. BELONGS TO THE ESAT6 FAMILY. X2BPJ5,P0A565 No cell wall and cell processes Rv3875 NC_002945.3 Mycobrowser_v2 CDS 4289330 4291330 . + 0 Mb3906 espi esx-1 secretion-associated protein espi. conserved proline and alanine rich protein. Mb3906, -, len: 666 aa. Equivalent to Rv3876, len: 666 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 666 aa overlap). Conserved hypothetical pro-, ala-rich protein, similar to several proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 HYPOTHETICAL PROTEIN (586 aa), FASTA scores: opt: 1682,E(): 2.1e-45, (50.75% identity in 672 aa overlap); O33082|MLCB628.11c HYPOTHETICAL 52.0 KDA PROTEIN (478 aa),FASTA scores: opt: 1588, E(): 1.5e-42, (53.5% identity in 542 aa overlap) (also has a proline rich N-terminus); etc. Also similar to other proteins from Mycobacterium tuberculosis, especially in C-terminus, e.g. O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 670, E(): 2.5e-14, (34.85% identity in 396 aa overlap) (also has Pro-rich N-terminus); etc. Note that N-terminus is repetitive and highly Proline rich. Q7TVG2 No cell wall and cell processes Rv3876 NC_002945.3 Mycobrowser_v2 CDS 4301344 4303203 . - 0 Mb3914c ecca2 esx conserved component ecca2. esx-2 type vii secretion system protein. probable cbxx/cfqx family protein. Mb3914c, -, len: 619 aa. Equivalent to Rv3884c,len: 619 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 619 aa overlap). Putative CBXX/CFQX protein family, similar to hypothetical proteins from Mycobacterium leprae e.g. Q9CD28|Y282_MYCLE|ML2537 (640 aa), FASTA scores: opt: 725, E(): 2.9e-34, (28.95% identity in 587 aa overlap); O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (BELONGS TO THE CBXX/CFQX FAMILY) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa overlap). Also similar to proteins belonging to the CBXX/CFQX FAMILY e.g. Q9RKZ2|SC6D7.05c PUTATIVE CBXX/CFQX FAMILY PROTEIN from Streptomyces coelicolor (618 aa) FASTA scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ STAGE V SPORULATION PROTEIN K from Bacillus subtilis (322 aa) FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in 280 aa overlap) (similarity only at C-terminus); Q9KAC6|BH2363 STAGE V SPORULATION PROTEIN K from Bacillus halodurans (315 aa), FASTA scores: opt: 462, E(): 2.2e-19,(36.05% identity in 244 aa overlap) (similarity only at C-terminus); etc. And similar to hypothetical proteins from Mycobacterium tuberculosis belonging to the CBXX/CFQX FAMILY e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 743, E(): 2.6e-35, (29.9% identity in 612 aa overlap); O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 HYPOTHETICAL 62.4 KDA PROTEIN (573 aa), FASTA scores: opt: 678, E(): 1.3e-31, (31.25% identity in 589 aa overlap); O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SEEMS TO BELONG TO THE CBXX/CFQX FAMILY. X2BQ44,P59976 No cell wall and cell processes Rv3884c NC_002945.3 Mycobrowser_v2 CDS 4291327 4292862 . + 0 Mb3907 eccd1 esx conserved component eccd1. esx-1 type vii secretion system protein. probable transmembrane protein. Mb3907, -, len: 511 aa. Equivalent to Rv3877, len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CDD9|ML0047 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (512 aa), FASTA scores: opt: 2496, E(): 2.8e-140, (74.0% identity in 512 aa overlap); and highly similar, but longer 32 aa, to O33081|MLCB628.10c HYPOTHETICAL 51.4 KDA PROTEIN from Mycobacterium leprae (480 aa), FASTA scores: opt: 2346, E(): 2e-131, (74.15% identity in 480 aa overlap). Shows also similarity with other membrane proteins from Mycobacterium leprae e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 318, E(): 2e-11, (22.7% identity in 520 aa overlap). Also similar to various proteins from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 391, E(): 9.4e-16, (24.45% identity in 523 aa overlap); O86362|Rv0290|MTV035.18 HYPOTHETICAL 47.9 KDA PROTEIN (472 aa), FASTA scores: opt: 332, E(): 2.8e-12, (28.1% identity in 509 aa overlap); O05457|Rv3887c|MTCY15F10.25 HYPOTHETICAL 53.2 KDA PROTEIN (509 aa), FASTA scores: opt: 167, E(): 0.017, (24.0% identity in 517 aa overlap); etc. Equivalent to AAK48359 from Mycobacterium tuberculosis strain CDC1551 (479 aa) but longer 32 aa. Q7TVG1 No cell wall and cell processes Rv3877 NC_002945.3 Mycobrowser_v2 CDS 4293013 4293855 . + 0 Mb3908 espj esx-1 secretion-associated protein espj. conserved alanine rich protein. Mb3908, -, len: 280 aa. Equivalent to Rv3878, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 280 aa overlap). Hypothetical unknown ala-rich protein. Q7TVG0 No cell wall and cell processes Rv3878 NC_002945.3 Mycobrowser_v2 CDS 4293913 4296147 . - 0 Mb3909c espk esx-1 secretion-associated protein espk. alanine and proline rich protein. Mb3909c, -, len: 744 aa. Equivalent to Rv3879c,len: 729 aa, from Mycobacterium tuberculosis strain H37Rv,(98.0% identity in 743 aa overlap). Hypothetical unknown ala-, pro-rich protein (N-terminal end is repetitive and highly Proline-rich). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 27 bp and 18 bp lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (744 aa versus 729 aa). Q7TVF9 No cell wall and cell processes Rv3879c NC_002945.3 Mycobrowser_v2 CDS 4298397 4299785 . - 0 Mb3912c ecce1 esx conserved component ecce1. esx-1 type vii secretion system protein. possible membrane protein. Mb3912c, -, len: 462 aa. Equivalent to Rv3882c,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Possible conserved membrane protein, equivalent to O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 2346, E(): 1.1e-140, (72.1% identity in 462 aa overlap). Also similar to O05459|Rv3885c|MTCY15F10.27 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (537 aa) FASTA scores: opt: 283, E(): 2.5e-10, (26.8% identity in 414 aa overlap); and C-terminal end shows similarity with AAK48368|MT4000 HYPOTHETICAL 45.6 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (422 aa) FASTA scores: opt: 215, E(): 4.1e-06, (26.85% identity in 320 aa overlap). Q7TVF7 No cell wall and cell processes Rv3882c NC_002945.3 Mycobrowser_v2 CDS 4299782 4301122 . - 0 Mb3913c mycp1 membrane-anchored mycosin mycp1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1) Mb3913c, -, len: 446 aa. Equivalent to Rv3883c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 446 aa overlap). Possible secreted protease (EC 3.4.-.-), equivalent to O33076|ML0041|MLCB628.04 PROBABLE SECRETED PROTEASE from Mycobacterium leprae (446 aa), FASTA scores: opt: 2448,E(): 1.5e-124, (79.15% identity in 446 aa overlap); and highly similar, but in part, to several putative proteases from Mycobacterium leprae; Q9CBV3|ML1538 (567 aa) FASTA scores: opt: 902, E(): 3e-41, (37.25% identity in 556 aa overlap); and Q9CD36|ML2528 (475 aa), FASTA scores: opt: 873, E(): 9.4e-40, (42.7% identity in 459 aa overlap). Shows also similarity with several proteases from other organisms e.g. Q9PCD0|XF1851 SERINE PROTEASE from Xylella fastidiosa (1000 aa), FASTA scores: opt: 281, E(): 1.3e-07, (27.95% identity in 422 aa overlap); P42780|BPRX_BACNO EXTRACELLULAR SUBTILISIN-LIKE PROTEASE PRECURSOR (EC 3.4.21.-) from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 270,E(): 3.2e-07, (28.9% identity in 384 aa overlap); Q46541|APRV5 ACIDIC PROTEASE V5 from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 264,E(): 6.8e-07, (28.65% identity in 384 aa overlap); etc. Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53695|Rv0291|MTV035.19 PUTATIVE PROTEASE (461 aa), FASTA scores: opt: 1168, E(): 1.2e-55,(44.6% identity in 453 aa overlap); O53945|Rv1796|MTV049.18 HYPOTHETICAL 60.0 KDA PROTEIN (585 aa), FASTA scores: opt: 928, E(): 1.2e-42, (37.85% identity in 555 aa overlap) (note gap from aa 155-264); and downstream ORF O05458|Rv3886c|MTCY15F10.26 HYPOTHETICAL 55.6 KDA PROTEIN (550 aa), FASTA scores: opt: 910, E(): 1.1e-41, (40.15% identity in 533 aa overlap) (note partial gap from aa 146-234); etc. Equivalent to AAK48366 from Mycobacterium tuberculosis strain CDC1551 (411 aa) but longer 35 aa. Has signal sequence with possible signal peptidase I cleavage site in residues 19-21 (ASA) and hydrophobic stretch at C-terminus,followed by short positively charged segment, that could act as membrane anchor. Q7TVF6 No intermediary metabolism and respiration Rv3883c NC_002945.3 Mycobrowser_v2 CDS 4303273 4304886 . - 0 Mb3915c ecce2 esx conserved component ecce2. esx-2 type vii secretion system protein. possible membrane protein. Mb3915c, -, len: 537 aa. Equivalent to Rv3885c,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 537 aa overlap). Possible conserved membrane protein (has hydrophobic stretch near N-terminus), showing some similarity with O05462|Rv3882c|MTV027.17c|MTCY15F10.30 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (462 aa) FASTA scores: opt: 283, E(): 8.3e-10, (26.55% identity in 414 aa overlap); and O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 260, E(): 2.1e-08, (28.0% identity in 382 aa overlap). Equivalent to AAK48368 from Mycobacterium tuberculosis strain CDC1551 (422 aa) but longer 115 aa. Q7TVF5 No cell wall and cell processes Rv3885c NC_002945.3 Mycobrowser_v2 CDS 4310219 4311904 . - 0 Mb3923c eccc2 POSSIBLE CONSERVED MEMBRANE PROTEIN [SECOND PART] Mb3923c, -, len: 561 aa. Equivalent to 3' end of Rv3894c, len: 1396 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 561 aa overlap). Possible conserved membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 652, E(): 2.2e-30,(27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa),FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 523, E(): 8.6e-23, (31.65% identity in 1412 aa overlap). Also similar to various proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 973, E(): 2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23,(24.95% identity in 1450 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),FASTA scores: opt: 444, E(): 4.1e-18, (22.5% identity in 1346 aa overlap); etc. Also similar to AAK46103|MT1833 FTSK/SPOIIIE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt: 769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap); and other hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391 aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa overlap) (similarity only with C-terminal end); etc. Contains two possible (PS00017) ATP/GTP-binding sites (P-loop) in central portion. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts, Mb3923c and Mb3924c. Q7TVE7 No NC_002945.3 Mycobrowser_v2 CDS 4324398 4324670 . - 0 Mb3934c esxE putative esat-6 like protein esxe (hypothetical alanine rich protein) (esat-6 like protein 12) Mb3934c, esxE, len: 90 aa. Equivalent to Rv3904c,len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 90 aa overlap). esxE, putative ESAT-6 like protein 12, hypothetical unknown ala-rich protein. BELONGS TO THE ESAT6 FAMILY. Q7TVD7 No NC_002945.3 Mycobrowser_v2 CDS 4304883 4306535 . - 0 Mb3916c mycp2 probable alanine and proline rich membrane-anchored mycosin mycp2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2) Mb3916c, -, len: 550 aa. Equivalent to Rv3886c,len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 550 aa overlap). Probable ala-,pro-rich protease (EC 3.4.-.-), highly similar to Q9CBV3|ML1538 POSSIBLE PROTEASE from Mycobacterium leprae (567 aa), FASTA scores: opt: 1034, E(): 3.9e-32, (43.5% identity in 575 aa overlap); and highly similar, but with gaps, to several putative proteases from Mycobacterium leprae; O33076|ML0041|MLCB628.04 (446 aa), FASTA scores: opt: 860, E(): 1.1e-25, (38.65% identity in 538 aa overlap); Q9CD36|ML2528 (475 aa) (475 aa), FASTA scores: opt: 413, E(): 7.1e-09, (37.7% identity in 562 aa overlap). Also similarity with Q99405|PRTM_BACSP M-PROTEASE (EC 3.4.21.-) from Bacillus sp. strain KSM-K16 (269 aa), FASTA scores: E(): 7.6e-06, (27.1% identity in 277 aa overlap). And highly similar, but also with gaps,to hypothetical proteins from Mycobacterium tuberculosis e.g. O53945|Rv1796|MTV049.18 (585 aa), FASTA scores: opt: 1173, E(): 2.4e-37, (47.9% identity in 578 aa overlap); the upstream ORF O05461|Rv3883c|MTCY15F10.29 (446 aa) FASTA scores: opt: 910, E(): 1.5e-27, (40.15% identity in 533 aa overlap); O06316|Rv3449|MTCY13E12.02 (455 aa) FASTA scores: opt: 477, E(): 2.7e-11, (38.75% identity in 550 aa overlap); etc. Pro rich protein with two serine protease,subtilase family active site motifs: aspartic acid active site motif (PS00136); and histidine active site motif (PS00137). BELONGS TO PEPTIDASE FAMILY S8; ALSO KNOWN AS THE SUBTILASE FAMILY. Q7TVF4 No intermediary metabolism and respiration Rv3886c NC_002945.3 Mycobrowser_v2 CDS 4306520 4307389 . - 0 Mb3917c eccd2 esx conserved component eccd2. esx-2 type vii secretion system protein. probable transmembrane protein. Mb3917c, -, len: 289 aa. Equivalent to 3' end of Rv3887c, len: 509 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 288 aa overlap). Probable conserved transmembrane protein (has hydrophilic stretch from ~1-130 then very hydrophobic domain), similar to other membrane proteins and with weak similarity to known transporters, e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN from Mycobacterium leprae (503 aa), FASTA scores: opt: 395, E(): 2.3e-16, (28.0% identity in 496 aa overlap); Q9CD35|ML2529 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (485 aa), FASTA scores: opt: 221,E(): 6.6e-06, (24.6% identity in 423 aa overlap); Q9ADP8|2SC10A7.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (430 aa), FASTA scores: opt: 171,E(): 0.0062, (26.55% identity in 358 aa overlap); CAC44275|SCBAC17F8.03 PUTATIVE DRUG EFFLUX PROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 160,E(): 0.028, (27.85% identity in 323 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 360, E(): 2.9e-14, (26.65% identity in 514 aa overlap); etc. Equivalent to AAK48369 from Mycobacterium tuberculosis strain CDC1551 (469 aa) but longer 40 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 2406 bp leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv. Q7TVF3 No NC_002945.3 Mycobrowser_v2 CDS 4307371 4307589 . - 0 Mb3918c espg2 esx-2 secretion-associated protein espg2 Mb3918c, -, len: 72 aa. Equivalent to 5' end of Rv3889c, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 68 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv. Q7TVF2 No NC_002945.3 Mycobrowser_v2 CDS 4307597 4307971 . - 0 Mb3919c esxC esat-6 like protein esxc (esat-6 like protein 11) Mb3919c, esxC, len: 124 aa. Similar to Rv3890c,len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 55 aa overlap). esxC, putative ESAT-6 like protein 11, equivalent to Q9K548|ES6B_MYCPA PUTATIVE ESAT-6 LIKE PROTEIN 11 (ORF3890C) from Mycobacterium paratuberculo sis (95 aa), FASTA scores: opt: 490, E(): 3.3e-26, (76.85% identity in 95 aa overlap). BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (125 aa versus 95 aa). Q7TVF1 No NC_002945.3 Mycobrowser_v2 CDS 4308007 4308330 . - 0 Mb3920c esxD possible esat-6 like protein esxd Mb3920c, esxD, len: 107 aa. Equivalent to Rv3891c,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 107 aa overlap). esxD, conserved hypothetical protein, equivalent to Q9K547 HYPOTHETICAL 10.3 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (100 aa), FASTA scores: opt: 498, E(): 1.7e-26, (77.25% identity in 101 aa overlap). Q7TVF0 No NC_002945.3 Mycobrowser_v2 CDS 4308441 4309640 . - 0 Mb3921c PPE69 ppe family protein ppe69 Mb3921c, PPE69, len: 399 aa. Equivalent to Rv3892c,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 399 aa overlap). Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348, E(): 2.2e-08, (26.6% identity in 380 aa overlap). Q7TVE9 No NC_002945.3 Mycobrowser_v2 CDS 4309719 4309952 . - 0 Mb3922c PE36 pe family protein pe36 Mb3922c, PE36, len: 77 aa. Equivalent to Rv3893c,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Member of the Mycobacterium tuberculosis PE family of conserved proteins, similar to other e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). Q7TVE8 No NC_002945.3 Mycobrowser_v2 CDS 4314411 4315898 . - 0 Mb3925c eccb2 esx conserved component eccb2. esx-2 type vii secretion system protein. probable membrane protein. Mb3925c, -, len: 495 aa. Equivalent to Rv3895c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Possible conserved membrane protein, highly similar to two CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae: Q9Z5I3|ML1544|MLCB596.27 (506 aa), FASTA scores: opt: 1070, E(): 1.4e-53, (39.8% identity in 485 aa overlap); and Q9CD29|ML2536 (552 aa), FASTA scores: opt: 483, E(): 4e-20, (36.85% identity in 499 aa overlap). Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53933|Rv1782|MTV049.04 HYPOTHETICAL PROTEIN (506 aa), FASTA scores: opt: 1106, E(): 1.2e-55,(41.25% identity in 485 aa overlap); O69734|Rv3869|MTV027.04 HYPOTHETICAL PROTEIN (480 aa),FASTA scores: opt: 795, E(): 6.1e-38, (36.0% identity in 486 aa overlap); O33088|ML0054|MLCB628.17c PUTATIVE MEMBRANE PROTEIN) (481 aa), FASTA scores: opt: 740, E(): 8.3e-35, (35.65% identity in 485 aa overlap); etc. Q7TVE5 No cell wall and cell processes Rv3895c NC_002945.3 Mycobrowser_v2 CDS 4315942 4316808 . - 0 Mb3926c CONSERVED HYPOTHETICAL PROTEIN Mb3926c, -, len: 288 aa. Similar to Rv3896c, len: 302 aa (first GTG taken, although TBparse suggests TTG at 16079), from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 249 aa overlap). Putative conserved ala-rich protein. C-terminus highly similar to C-terminal end of other proteins e.g. Q9XAS4|SC10A7.01 HYPOTHETICAL 17.2 KDA PROTEIN from Streptomyces coelicolor (244 aa),FASTA scores: opt: 255, E(): 1.4e-08, (32.0% identity in 222 aa overlap); CAC44611|STBAC16H6.32 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (172 aa), FASTA scores: opt: 214, E(): 3.4e-06, (42.55% identity in 94 aa overlap); Q38352|ORF360 from Lactococcus delbrueckii bacteriophage LL-H (360 aa), FASTA scores: opt: 211, E(): 9.5e-06, (40.0% identity in 115 aa overlap); P54334|XKDO_BACSU|XKDO PHAGE-LIKE ELEMENT PBSX PROTEIN from Bacillus subtilis (1332 aa), FASTA scores: opt: 209,E(): 3.6e-05, (38.35% identity in 86 aa overlap); etc. Also similar to P71594|P71594|Rv0024|MTCY10H4.24 HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium tuberculosis (281 aa), FASTA scores: opt: 265, E(): 3.9e-09, (29.25% identity in 287 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a product with a different COOH part than in Mycobacterium tuberculosis (288 aa versus 302 aa). Q7TVE4 No NC_002945.3 Mycobrowser_v2 CDS 4316958 4317947 . - 0 Mb3927c CONSERVED HYPOTHETICAL PROTEIN Mb3927c, -, len: 329 aa. Equivalent to Rv3898c and Rv3897c, len: 110 aa and 210 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 110 aa overlap and 98.8% identity in 168 aa overlap). Conserved hypothetical proteins. Highly similar, but in part, to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 HYPOTHETICAL 30.8 KDA PROTEIN from Mycobacterium tuberculosis (314 aa) FASTA scores: opt: 204, E(): 0.00042, (50.6% identity in 81 aa overlap) and FASTA scores: opt: 815, E(): 4.7e-26,(73.05% identity in 167 aa overlap). Similarity suggests it should be in frame with next ORF and that the stop codon could be read through, the sequence appears to be correct. Homology lost upstream at 15138 gatc sequence may suggest discontinuity due to chimerism in cY15F10 or cY49. Similarity to MTCY49.22 suggests that this is a continuation of MTCY15F10.14. There is a frameshift mutation near 3'-end with respect to this sequence as well, similarity to MTCY49.22 continues in an overlapping ORF. Sequence appears to be correct. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis, a single base transition (t-c) leads to a single product. Q7TVE3 No conserved hypotheticals Rv3898c NC_002945.3 Mycobrowser_v2 CDS 4324819 4324992 . - 0 Mb3935c esxF putative esat-6 like protein esxf (hypothetical alanine and glycine rich protein) (esat-6 like protein 13) Mb3935c, esxF, len: 57 aa. Equivalent to Rv3905c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). esxF, putative ESAT-6 like protein 13, hypothetical unknown ala-, gly-rich protein, ESAT-6 like protein. BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (g-a) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa). Q7TVD6 No NC_002945.3 Mycobrowser_v2 CDS 4318109 4318990 . - 0 Mb3928c CONSERVED HYPOTHETICAL PROTEIN Mb3928c, -, len: 293 aa. Equivalent to 3' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 293 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product. Q7TVE2 No NC_002945.3 Mycobrowser_v2 CDS 4318597 4319340 . - 0 Mb3929c CONSERVED HYPOTHETICAL PROTEIN Mb3929c, -, len: 247 aa. Equivalent to 5' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (90.8% identity in 130 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. In Mycobacterium tuberculosis strain H37Rv,Rv3899c (len: 410 aa) exists as a single gene on a single reading frame. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product. No NC_002945.3 Mycobrowser_v2 CDS 4319334 4320269 . - 0 Mb3930c CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN Mb3930c, -, len: 311 aa. Equivalent to Rv3900c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 311 aa overlap). Conserved hypothetical ala-rich protein, highly similar to N-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN from Mycobacterium tuberculosis (721 aa), FASTA scores: opt: 592, E(): 2.7e-22, (37.15% identity in 280 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. Q7TVE1 No conserved hypotheticals Rv3900c NC_002945.3 Mycobrowser_v2 CDS 4321853 4324393 . - 0 Mb3933c HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN Mb3933c, -, len: 846 aa. Equivalent to Rv3903c,len: 846 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 846 aa overlap). Hypothetical unknown ala-, pro-rich protein. Q7TVD8 No conserved hypotheticals Rv3903c NC_002945.3 Mycobrowser_v2 CDS 4325058 4325567 . - 0 Mb3936c CONSERVED HYPOTHETICAL PROTEIN Mb3936c, -, len: 169 aa. Equivalent to Rv3906c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Conserved hypothetical protein, strongly related to Q50578|AT9S (SOD related in Escherichia coli) from Mycobacterium tuberculosis strain AOYAMA B (155 aa), but apparently different as flanking sequences differ and shorter 43 aa,FASTA scores: opt: 548, E(): 1.3e-26, (79.4% identity in 102 aa overlap). Selfmarch results suggest that Rv3906c is not related to any other hypothetical protein from M. tuberculosis strain H37Rv except itself. Shows also similarity with Q9VFR2|CG9297 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (930 aa), FASTA scores: opt: 221, E(): 4.9e-06, (36.95% identity in 157 aa overlap); Q9HQ55|CBP|VNG1320G CALCIUM-BINDING PROTEIN HOMOLOGY from Halobacterium sp. strain NRC-1 (385 aa) FASTA scores: opt: 143, E(): 0.13, (35.65% identity in 160 aa overlap); Q24795 CALCIUM-BINDING PROTEIN (FRAGMENT) from Echinococcus granulosus (338 aa), FASTA scores: opt: 140, E(): 0.17, (33.95% identity in 156 aa overlap). Q7TVD5 No conserved hypotheticals Rv3906c NC_002945.3 Mycobrowser_v2 CDS 4325592 4327034 . - 0 Mb3937c pcnA probable poly(a) polymerase pcna (polynucleotide adenylyltransferase) (ntp polymerase) (rna adenylating enzyme) (poly(a) polymerase) Mb3937c, pcnA, len: 480 aa. Equivalent to Rv3907c,len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Probable pcnA,polynucleotide polymerase (EC 2.7.7.19), equivalent to Q9CCY1|PCNA|ML2697 PCNA PROTEIN from Mycobacterium leprae (486 aa), FASTA scores: opt: 2713, E(): 4.3e-160, (84.1% identity in 478 aa overlap); and Q59534|PCNB POLYA POLYMERASE from Mycobacterium leprae (411 aa) FASTA scores: opt: 2077, E(): 7.1e-121, (82.55% identity in 373 aa overlap). Also highly similar to many e.g. Q9X8T2|SCH24.18 PUTATIVE RNA NUCLEOTIDYLTRANSFERASE from Streptomyces coelicolor (483 aa), FASTA scores: opt: 1856,E(): 3.7e-107, (61.55% identity in 455 aa overlap); Q9ZN65 POLYA POLYMERASE from Prevotella ruminicola (Bacteroides ruminicola) (479 aa), FASTA scores: opt: 830, E(): 8.5e-44, (34.85% identity in 445 aa overlap); P42977|PAPS_BACSU POLY(A) POLYMERASE from Bacillus subtilis (397 aa), FASTA scores: opt: 479, E(): 3.5e-22,(29.35% identity in 450 aa overlap); etc. Contains: PS00017 ATP/GTP-binding site motif A (P-loop), PS00018 EF-hand calcium-binding domain, and probably less significant a PS00237 G-protein coupled receptor signature, and PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. BELONGS TO THE TRNA NUCLEOTIDYLTRANSFERASE / POLY(A) POLYMERASE FAMILY. Q7TVD4 No NC_002945.3 Mycobrowser_v2 CDS 4327410 4328156 . + 0 Mb3938 mutt4 possible mutator protein mutt4 Mb3938, -, len: 248 aa. Equivalent to Rv3908, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Conserved hypothetical protein, equivalent to Q50195|ML2698|L222-ORF6 HYPOTHETICAL PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 1270,E(): 3.4e-62, (79.05% identity in 248 aa overlap). Also similar to O66548|APFA|AQ_158 HYDROLASE from Aquifex aeolicus (134 aa), FASTA scores: opt: 300, E(): 1.1e-09,(37.3% identity in 142 aa overlap); and similarity with other various proteins e.g. O93721 DIADENOSINE 5'5'''-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Pyrobaculum aerophilum (143 aa), FASTA scores: opt: 205,E(): 0.00017, (34.85% identity in 109 aa overlap); Q9HS29|APA|VNG0431G DIADENOSINE TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Halobacterium sp. strain NRC-1 (142 aa), FASTA scores: opt: 199, E(): 0.00036, (34.0% identity in 147 aa overlap); Q9YA58|APE2080 HYPOTHETICAL 19.2 KDA PROTEIN from Aeropyrum pernix (175 aa) FASTA scores: opt: 191, E(): 0.0012, (36.9% identity in 141 aa overlap); etc. Also similar to P95110|MUTT1|Rv2985|MTCY349.02 HYPOTHETICAL 34.7 KDA PROTEIN from Mycobacterium tuberculosis (317 aa) FASTA scores: opt: 224, E(): 3e-05, (34.05% identity in 144 aa overlap). Q7TVD3 No information pathways Rv3908 NC_002945.3 Mycobrowser_v2 CDS 4328153 4330561 . + 0 Mb3939 conserved protein Mb3939, -, len: 802 aa. Equivalent to Rv3909, len: 802 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 802 aa overlap). Conserved hypothetical protein, equivalent to Q9CCY0|ML2699 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (797 aa) FASTA scores: opt: 3777, E(): 8.8e-206, (72.35% identity in 803 aa overlap). Note that the N-terminal end is highly similar to Q50196|L222-ORF7 (286 aa), FASTA scores: opt: 1213,E(): 2.7e-61, (71.75% identity in 255 aa overlap); and the C-terminal end is highly similar to Q50197|L222-ORF8 also from Mycobacterium leprae (512 aa) FASTA scores: opt: 2375, E(): 9.9e-127, (71.8% identity in 518 aa overlap). Shows some similarity with N-terminal end of Q9I2M3|PA1874 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (2468 aa), FASTA scores: opt: 171, E(): 0.13, (22.9% identity in 672 aa overlap). Q7TVD2 No conserved hypotheticals Rv3909 NC_002945.3 Mycobrowser_v2 CDS 4334147 4334737 . + 0 Mb3941 sigMa POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMa [FIRST PART] Mb3941, sigMa, len: 196 aa. Similar to Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(95.8% identity in 168 aa overlap). Possible sigM,alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) PUTATIVE RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa),FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb. Q7TVD0 No NC_002945.3 Mycobrowser_v2 CDS 4334626 4334814 . + 0 Mb3942 sigMb POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMb [SECOND PART] Mb3942, sigMb, len: 62 aa. Equivalent to 3' end of Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Possible sigM, alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) PUTATIVE RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa), FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb. No NC_002945.3 Mycobrowser_v2 CDS 4335688 4336695 . + 0 Mb3944 trxB2 PROBABLE THIOREDOXIN REDUCTASE TRXB2 (TRXR) (TR) Mb3944, trxB2, len: 335 aa. Equivalent to Rv3913,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 335 aa overlap). Probable trxB2,thioredoxin reductase (EC 1.6.4.5) (see citation below),equivalent to O30973|TRXB_MYCSM THIOREDOXIN REDUCTASE from Mycobacterium smegmatis (311 aa), FASTA scores: opt: 1575,E(): 1.8e-87, (78.35% identity in 305 aa overlap); and highly similar, but shorter at C-terminus, to P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 1766, E(): 8.7e-99,(83.25% identity in 328 aa overlap). Also highly similar to many e.g. P52215|TRXB_STRCO|SCH24.12 from Streptomyces coelicolor (321 aa), FASTA scores: opt: 1249, E(): 7.2e-68, (60.4% identity in 313 aa overlap); Q9Z8M4|TRXB_CHLPN from Chlamydia pneumoniae (Chlamydophila pneumoniae) (311 aa), FASTA scores: opt: 978, E(): 1.3e-51, (49.85% identity in 307 aa overlap); P09625|TRXB_ECOLI|B0888 from Escherichia coli strain K12 (320 aa), FASTA scores: opt: 948, E(): 8.6e-50, (49.2% identity in 309 aa overlap); etc. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-II. COFACTOR: FAD (BY SIMILARITY). Q7TVC8 No NC_002945.3 Mycobrowser_v2 CDS 4336692 4337042 . + 0 Mb3945 trxC THIOREDOXIN TRXC (TRX) (MPT46) Mb3945, trxC, len: 116 aa. Equivalent to Rv3914,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). trxC (alternate gene names: trx, trxA *), thioredoxin (EC 1.-.-.-) (see citations below), equivalent to O30974|THIO_MYCSM|TRXA THIOREDOXIN from Mycobacterium smegmatis (112 aa), FASTA scores: opt: 576, E(): 2.1e-32, (80.2% identity in 111 aa overlap); and also equivalent to C-terminal end of P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 628, E(): E(): 2e-35,(82.9% identity in 117 aa overlap). Also highly similar to many e.g. P80579|THIO_ALIAC from Alicyclobacillus acidocaldarius (Bacillus acidocaldarius) (105 aa), FASTA scores: opt: 411, E(): 3e-21, (57.15% identity in 105 aa overlap); P00275|THI1_CORNE from Corynebacterium nephridii (105 aa), FASTA scores: opt: 394, E(): 4.3e-20, (56.7% identity in 97 aa overlap); P00274|THIO_ECOLI|TRXA|TSNC|FIPA|B3781 from Escherichia coli and Salmonella typhimurium strain K12 and LT2 respectively (108 aa), FASTA scores: opt: 364, E(): 4.7e-18, (54.45% identity in 101 aa overlap); etc. Also similar to O53162|TRXB|Rv1471|MTV007.18 THIOREDOXIN from Mycobacterium tuberculosis (123 aa), FASTA scores: E(): 2.3e-15, (41.9% identity in 93 aa overlap). Contains PS00194 Thioredoxin family active site. BELONGS TO THE THIOREDOXIN FAMILY. The product of this CDS is supposed secreted. In this cas, this protein could exert its free radical scavenging activity inside macrophages. (*) Warning: note that Rv1470|MTV007.17 correspond also to trxA. X2BPP7,P0A617 No intermediary metabolism and respiration Rv3914 NC_002945.3 Mycobrowser_v2 CDS 4337152 4338372 . + 0 Mb3946 probable peptidoglycan hydrolase Mb3946, -, len: 406 aa. Equivalent to Rv3915, len: 406 aa, from Myobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable hydrolase (EC 3.-.-.-), equivalent to Q9CCX8|ML2704 PUTATIVE HYDROLASE from Mycobacterium leprae (406 aa) FASTA scores: opt: 2341, E(): 2.7e-138, (86.95% identity in 406 aa overlap); the N-terminal end is highly similar to Q59535 N-ACETYMURAMYL-L-ALANINE AMIDASE (EC 3.5.1.28) from Mycobacterium leprae (205 aa), FASTA scores: opt: 1046,E(): 5.7e-58, (84.85% identity in 185 aa overlap). Also similar to other hydrolases (especially amidases (EC 3.5.-.-)) e.g. C-terminal end of Q9K6R3|LYTC|BH3665 N-ACETYLMURAMOYL-L-ALANINE AMIDASE (MAJOR AUTOLYSIN) from Bacillus halodurans (588 aa), FASTA scores: opt: 363, E(): 4.3e-15, (33.15% identity in 356 aa overlap); Q9PKC7|TC0539 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE from Chlamydia muridarum (268 aa), FASTA scores: opt: 285,E(): 1.6e-10, (26.05% identity in 242 aa overlap) (RV3915 product appears longer 127 aa); Q9S596|PDCA PENICILLIN-RESISTANT DD-CARBOXYPEPTIDASE (EC 3.4.-.-) from Myxococcus xanthus (302 aa), FASTA scores: opt: 270, E(): 1.5e-09, (39.85% identity in 158 aa overlap); etc. Note that previously known as cwlM. Q7TVC7 No intermediary metabolism and respiration Rv3915 NC_002945.3 Mycobrowser_v2 CDS 4339417 4340451 . - 0 Mb3948c parB PROBABLE CHROMOSOME PARTITIONING PROTEIN PARB Mb3948c, parB, len: 344 aa. Equivalent to Rv3917c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable parB,chromosome partitioning protein, equivalent to Q50201|PARB_MYCLE|ML2706 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium leprae (333 aa), FASTA scores: opt: 1654, E(): 1.6e-88, (78.6% identity in 332 aa overlap). Also highly similar to to others e.g. Q9S6U1|STH24.09 PUTATIVE PARTITIONING OR SPORULATION PROTEIN from Streptomyces coelicolor (328 aa), FASTA scores: opt: 966, E(): 9.7e-49, (58.55% identity in 287 aa overlap) (no similarity on N-terminus); Q9PB63|PARB_XYLFA|XF2281 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Xylella fastidiosa (310 aa), FASTA scores: opt: 598, E(): 1.8e-27, (38.65% identity in 326 aa overlap); P31857|PARB_PSEPU PROBABLE CHROMOSOME PARTITIONING PROTEIN from Pseudomonas putida (290 aa),FASTA scores: opt: 573, E(): 4.6e-26, (40.35% identity in 322 aa overlap); etc. Contains probable helix-turn-helix motif at aa 179 to 200 (Score 1150, +3.1 0 SD). BELONGS TO THE PARB FAMILY. Note that previously known as parA. X2BQ08,P0A5R3 No NC_002945.3 Mycobrowser_v2 CDS 4340448 4341491 . - 0 Mb3949c parA PROBABLE CHROMOSOME PARTITIONING PROTEIN PARA Mb3949c, parA, len: 347 aa. Equivalent to Rv3918c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Probable parA,chromosome partitioning protein, highly similar to Q9CCX7|PARA|ML2707 PUTATIVE CELL DIVISION PROTEIN from Mycobacterium leprae (351 aa), FASTA scores: opt: 1679,E(): 2.9e-93, (78.1% identity in 347 aa overlap). Also highly similar to others e.g. Q9RFM1|PARA PARA PROTEIN from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1197, E(): 2e-64, (60.45% identity in 306 aa overlap); Q98DZ3|MLL4479|PARA CHROMOSOME PARTITIONING PROTEIN from Rhizobium loti (Mesorhizobium loti) (266 aa), FASTA scores: opt: 835, E(): 7.2e-43, (50.95% identity in 257 aa overlap); O05189|PARA_CAUCR CHROMOSOME PARTITIONING PROTEIN from Caulobacter crescentus (267 aa), FASTA scores: opt: 813, E(): 1.5e-41, (51.35% identity in 261 aa overlap) (has its N-terminus shorter); etc. Equivalent to AAK48403 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 34 aa. Also similar to other M. tuberculosis proteins: MTCI125.30, FASTA scores: E(): 4.3e-32, (35.2% identity in 327 aa overlap); and MTCY07D11.13, FASTA scores: E(): 3e-30, (39.9% identity in 263 aa overlap). BELONGS TO THE PARA FAMILY. Possible alternative start site at aa 107. Note that previously known as parB. Q7TVC5 No NC_002945.3 Mycobrowser_v2 CDS 4341488 4342162 . - 0 Mb3950c gid PROBABLE GLUCOSE-INHIBITED DIVISION PROTEIN B GID Mb3950c, gid, len: 224 aa. Equivalent to Rv3919c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Probable gid (alternate gene name: gidB), glucose-inhibited division protein B, equivalent, but shorter 20 aa, to Q9L7M3 PUTATIVE GIDB (FRAGMENT) from Mycobacterium paratuberculosis (245 aa), FASTA scores: opt: 1018, E(): 4.8e-57, (73.95% identity in 211 aa overlap); and Q50203|GIDB_MYCLE|ML2708 GLUCOSE INHIBITED DIVISION PROTEIN B from Mycobacterium leprae (245 aa), FASTA scores: opt: 966, E(): 9.1e-54, (68.4% identity in 212 aa overlap). Also highly similar to many e.g. O54571|GIDB_STRCO|STH24.07 from Streptomyces coelicolor (239 aa), FASTA scores: opt: 654, E(): 3.9e-34, (47.95% identity in 221 aa overlap); Q9KNG5|VC2774 from Vibrio cholerae (210 aa), FASTA scores: opt: 300, E(): 6.9e-12,(38.15% identity in 139 aa overlap); P17113|GIDB_ECOLI|B3740|Z5240|ECS4682 from Escherichia coli (several strains) (207 aa), FASTA scores: opt: 287,E(): 4.5e-11, (34.8% identity in 138 aa overlap); etc. Contains PS00539 Pyrokinins signature. BELONGS TO THE GIDB FAMILY. X2BPQ3,P59964 No NC_002945.3 Mycobrowser_v2 CDS 4342294 4342857 . - 0 Mb3951c conserved protein similar to jag protein Mb3951c, -, len: 187 aa. Equivalent to Rv3920c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Hypothetical protein,similar to JAG protein, equivalent to Q9L7M2 HYPOTHETICAL 20.1 KDA PROTEIN from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 HYPOTHETICAL PROTEIN SIMILAR TO JAG PROTEIN SPOIIIJ ASSOCIATED PROTEIN IN BACILLUS SUBTILIS from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44,(73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|JAG JAG-LIKE PROTEIN from Streptomyces coelicolor (170 aa), FASTA scores: opt: 593, E(): 6.7e-28, (62.85% identity in 167 aa overlap); Q9RCA6|JAG|BH4063 JAG PROTEIN HOMOLOG from Bacillus halodurans (207 aa), FASTA scores: opt: 282, E(): 1.1e-09, (35.0% identity in 140 aa overlap); Q9X1H1|TM1460 PUTATIVE JAG PROTEIN, PUTATIVE from Thermotoga maritima (221 aa), FASTA scores: opt: 258, E(): 3e-08, (31.9% identity in 138 aa overlap);Q01620|JAG_BACSU JAG PROTEIN (SPOIIIJ ASSOCIATED PROTEIN) from Bacillus subtilis (208 aa), FASTA scores: opt: 196, E(): 0.00012, (28.05% identity in 139 aa overlap); etc. Q7TVC4 No conserved hypotheticals Rv3920c NC_002945.3 Mycobrowser_v2 CDS 4342929 4344029 . - 0 Mb3952c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3952c, -, len: 366 aa. Equivalent to Rv3921c,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 366 aa overlap). Probable conserved transmembrane protein, equivalent to Q9L7M1 HYPOTHETICAL 39.2 KDA PROTEIN from Mycobacterium paratuberculosis (353 aa), FASTA scores: opt: 2001, E(): 8.4e-100, (83.05% identity in 366 aa overlap); Q9CCX6|ML2710 PUTATIVE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (380 aa), FASTA scores: opt: 1929, E(): 6.2e-96, (77.1% identity in 380 aa overlap); Q50205 CDS 27 on L222 from Mycobacterium leprae (312 aa) FASTA scores: opt: 1770,E(): 1.6e-87, (88.2% identity in 288 aa overlap). Also similar to other e.g. O54569|STH24.05 INNER MEMBRANE PROTEIN. from Streptomyces coelicolor (431 aa), FASTA scores: opt: 412, E(): 6.5e-15, (33.45% identity in 266 aa overlap); O84253|CT251 60 KDA INNER MEMBRANE PROTEIN from Chlamydia trachomatis (787 aa), FASTA scores: opt: 304,E(): 6e-09, (27.9% identity in 269 aa overlap); P29431|60IM_BUCAP 60 KDA INNER-MEMBRANE PROTEIN HOMOLOG from Buchnera aphidicola (subsp. Schizaphis graminum) (536 aa), FASTA scores: opt: 282, E(): 6.7e-08, (36.1% identity in 108 aa overlap); etc. X2BPQ9,P65627 No cell wall and cell processes Rv3921c NC_002945.3 Mycobrowser_v2 CDS 4344013 4344375 . - 0 Mb3953c POSSIBLE HEMOLYSIN Mb3953c, -, len: 120 aa. Equivalent to Rv3922c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). Possible hemolysin,highly similar to Q9L7M0|YIDD_MYCPA HYPOTHETICAL 12.4 KDA PROTEIN from Mycobacterium paratuberculosis (115 aa),FASTA scores: opt: 521, E(): 1.9e-29, (65.2% identity in 112 aa overlap). Also highly similar to Q44066|HLYA_AERHY PUTATIVE ALPHA-HEMOLYSIN from Aeromonas hydrophila (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap); and to many bacterial hypothetical proteins from bacterium e.g. P22847|YIDD_ECOLI|B3704.1 HYPOTHETICAL PROTEIN from Escherichia coli strain K12 (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap). X2BQ10,P67301 No virulence, detoxification, adaptation Rv3922c NC_002945.3 Mycobrowser_v2 CDS 3282790 3283638 . + 0 Mb2996 PROBABLE OXIDOREDUCTASE Mb2996, -, len: 282 aa. Equivalent to Rv2971, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly aldo/keto reductase,equivalent to O69462 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495,E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C OXIDOREDUCTASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 849, E(): 1.2e-49, (51.7% identity in 267 aa overlap); Q9ZBW7|SC4B5.01C PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49,(49.1% identity in 271 aa overlap); Q46857|YQHE_ECOLI|YQHE|B3012 HYPOTHETICAL OXIDOREDUCTASE from Escherichia coli strain K12 (275 aa), FASTA scores: opt: 827, E(): 3.7e-48, (47.45% identity in 276 aa overlap); etc. Contains PS00063 Aldo X2BMD1,Q7TXI6 No intermediary metabolism and respiration Rv2971 NC_002945.3 Mycobrowser_v2 CDS 3392345 3392869 . - 0 Mb3099c CONSERVED HYPOTHETICAL PROTEIN Mb3099c, -, len: 174 aa. Equivalent to Rv3072c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Hypothetical protein,similar in part to O87779 HYPOTHETICAL 18.1 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (166 aa),FASTA scores: opt: 238, E(): 2.5e-08, (42.6% identity in 108 aa overlap); Q9AH10 PUTATIVE F420-DEPENDENT DEHYDROGENASE from Rhodococcus erythropolis (295 aa),FASTA scores: opt: 228, E(): 1.7e-07, (34.25% identity in 111 aa overlap); P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 POSSIBLE OXIDOREDUCTASE from Mycobacterium tuberculosis strain H37Rv (304 aa), FASTA scores: opt: 208, E(): 3.2e-06, (38.9% identity in 108 aa overlap); etc. N-terminal region similar to several proteins from M. tuberculosis (see MAST results on the web site http: Q7TXB6 No conserved hypotheticals Rv3072c NC_002945.3 Mycobrowser_v2 CDS 4186173 4187300 . + 0 Mb3825 conserved protein Mb3825, -, len: 375 aa. Equivalent to Rv3796, len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 375 aa overlap). Conserved hypothetical protein. C-terminal end similar in part to Q983J3|MLR8305 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (227 aa), FASTA scores: opt: 288, E(): 4e-09,(38.95% identity in 154 aa overlap). Similar to P54548|YQJK_BACSU HYPOTHETICAL PROTEIN (BELONGS TO THE ATSA/ELAC FAMILY) from Bacillus subtilis (307 aa) FASTA scores: opt: 263, E(): 1.3e-07, (26.1% identity in 295 aa overlap); and some similarity to other proteins e.g. AAK46775|MT2479 PUTATIVE ARYLSULFATASE from Mycobacterium tuberculosis strain CDC1551 (224 aa), FASTA scores: opt: 194, E(): 0.00072, (25.85% identity in 259 aa overlap). Equivalent to AAK48269 from Mycobacterium tuberculosis strain CDC1551 (338 aa) but longer 37 aa. SOME SIMILARITY TO THE A. CARRAGEENOVORA ATSA Q7TVN2 No conserved hypotheticals Rv3796 NC_002945.3 Mycobrowser_v2 CDS 2523243 2523575 . - 0 Mb2292c HYPOTHETICAL PROTEIN Mb2292c, -, len: 110 aa. Equivalent to Rv2269c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Unknown protein. X2BKC5 No conserved hypotheticals Rv2269c NC_002945.3 Mycobrowser_v2 CDS 1244235 1244384 . - 0 Mb1150c HYPOTHETICAL PROTEIN Mb1150c, -, len: 49 aa. Equivalent to Rv1119c, len: 49 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 49 aa overlap). Hypothetical unknown protein. Q7U0L9 No conserved hypotheticals Rv1119c NC_002945.3 Mycobrowser_v2 CDS 1263293 1263529 . + 0 Mb1165 HYPOTHETICAL PROTEIN Mb1165, -, len: 78 aa. Equivalent to Rv1134, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 78 aa overlap). Hypothetical unknown protein. Q7U0K6 No conserved hypotheticals Rv1134 NC_002945.3 Mycobrowser_v2 tRNA 1177844 1177917 . + 0 leuX leuX tRNA-Leu leuX, len: 74 nt. Equivalent to leuX, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Leu, anticodon taa. No NC_002945.3 Mycobrowser_v2 tRNA 1813381 1813454 . - 0 leuV leuV tRNA-Leu leuV, len: 74 nt. Equivalent to leuV, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Leu, anticodon caa. No NC_002945.3 Mycobrowser_v2 tRNA 2559359 2559432 . - 0 metV metV tRNA-Met metV, len: 74 nt. Equivalent to metV, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Met, anticodon cat. No NC_002945.3 Mycobrowser_v2 tRNA 2597004 2597076 . - 0 asnT asnT tRNA-Asn asnT, len: 73 nt. Equivalent to asnT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Asn, anticodon gtt. No NC_002945.3 Mycobrowser_v2 CDS 2694029 2694229 . - 0 Mb2453c Mb2453c, -, len: 66 aa. Equivalent to the first part of oxyR' pseudogene (see citation below). No NC_002945.3 Mycobrowser_v2 tRNA 2733494 2733567 . - 0 proU proU tRNA-Pro proU, len: 74 nt. Equivalent to proU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro; anticodon tgg. No NC_002945.3 Mycobrowser_v2 CDS 2817888 2818115 . + 0 Mb2555 vapb17 possible antitoxin vapb17 Mb2555, -, len: 75 aa. Equivalent to Rv2526, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in aa overlap). Hypothetical unknown protein. Q7TYD6 No virulence, detoxification, adaptation Rv2526 NC_002945.3 Mycobrowser_v2 CDS 3624559 3624936 . - 0 Mb3317c POSSIBLE TRANSMEMBRANE PROTEIN Mb3317c, -, len: 125 aa. Equivalent to Rv3289c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Possible transmembrane protein, showing slight similarity to other membrane proteins or glycoproteins. Q7TWT3 No cell wall and cell processes Rv3289c NC_002945.3 Mycobrowser_v2 CDS 1800619 1801059 . + 0 Mb1641 probable membrane protein Mb1641, -, len: 146 aa. Equivalent to Rv1615, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Probable membrane protein. Q7VEW4 No cell wall and cell processes Rv1615 NC_002945.3 Mycobrowser_v2 tRNA 1444242 1444314 . - 0 argV argV tRNA-Arg argV, len: 73 nt. Equivalent to argV, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon ccg. No NC_002945.3 Mycobrowser_v2 tRNA 25625 25707 . + 0 leuT leuT tRNA-Leu leuT, len: 83 nt. Equivalent to leuT, len: 83 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 83 nt overlap). tRNA-Leu, anticodon cag. No NC_002945.3 Mycobrowser_v2 CDS 87243 87836 . - 0 Mb0081c HYPOTHETICAL PROTEIN Mb0081c, -, len: 197 aa. Equivalent to Rv0078A,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Hypothetical unknown protein. Q7U2W4 No conserved hypotheticals Rv0078A NC_002945.3 Mycobrowser_v2 CDS 162454 162693 . + 0 Mb0139-3 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-3, -, len: 80 aa. Pseudogene part3 of Rv0134/ephF No NC_002945.3 Mycobrowser_v2 CDS 238088 238591 . - 0 Mb0207c conserved protein Mb0207c, -, len: 167 aa. Equivalent to Rv0201c,len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622.15c from Mycobacterium leprae (170 aa), FASTA scores: opt: 646, E(): 0, (63.9% identity in 158 aa overlap). Q7U2K9 No conserved hypotheticals Rv0201c NC_002945.3 Mycobrowser_v2 CDS 1266458 1266826 . - 0 Mb1169c HYPOTHETICAL PROTEIN Mb1169c, -, len: 122 aa. Equivalent to Rv1137c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 122 aa overlap). Hypothetical unknown protein. Q7U0K2 No conserved hypotheticals Rv1137c NC_002945.3 Mycobrowser_v2 CDS 445861 446250 . - 0 Mb0374c HYPOTHETICAL PROTEIN Mb0374c, -, len: 129 aa. Equivalent to Rv0367c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Hypothetical unknown protein. Q7U260 No conserved hypotheticals Rv0367c NC_002945.3 Mycobrowser_v2 CDS 607300 607599 . + 0 Mb0527 POSSIBLE TRANSMEMBRANE PROTEIN Mb0527, -, len: 99 aa. Equivalent to Rv0514, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Possible transmembrane protein. Q7U1V8 No cell wall and cell processes Rv0514 NC_002945.3 Mycobrowser_v2 CDS 732349 732600 . + 0 Mb0652 unknown protein Mb0652, -, len: 83 aa. Equivalent to Rv0634A, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Hypothetical unknown protein. Q7U1K5 No conserved hypotheticals Rv0634A NC_002945.3 Mycobrowser_v2 tRNA 732730 732802 . + 0 thrT thrT tRNA-Thr thrT, len: 73 nt. Equivalent to thrT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Thr, anticodon ggt. No NC_002945.3 Mycobrowser_v2 CDS 787918 788715 . + 0 Mb0705 PROBABLE MEMBRANE PROTEIN Mb0705, -, len: 265 aa. Equivalent to Rv0686, len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 265 aa overlap). Probable membrane protein, with hydrophobic N-terminus. Q7U1G9 No cell wall and cell processes Rv0686 NC_002945.3 Mycobrowser_v2 tRNA 852832 852903 . - 0 thrV thrV tRNA-Thr thrV, len: 72 nt. Equivalent to thrV, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Thr, anticodon tgt. No NC_002945.3 Mycobrowser_v2 CDS 1372164 1372721 . + 0 Mb1260 lpqX probable lipoprotein lpqx Mb1260, lpqX, len: 185 aa. Equivalent to Rv1228,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 185 aa overlap). Probable lipoprotein LpqX. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U0C3 No cell wall and cell processes Rv1228 NC_002945.3 Mycobrowser_v2 CDS 945098 945490 . + 0 Mb0870 lpqS PROBABLE LIPOPROTEIN LPQS Mb0870, lpqS, len: 130 aa. Equivalent to Rv0847,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 130 aa overlap). Probable lpqS,lipoprotein. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U146 No cell wall and cell processes Rv0847 NC_002945.3 Mycobrowser_v2 CDS 2508042 2508236 . - 0 Mb2279c HYPOTHETICAL PROTEIN Mb2279c, -, len: 64 aa. Equivalent to Rv2255c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Hypothetical unknown protein. Q7TYW3 No conserved hypotheticals Rv2255c NC_002945.3 Mycobrowser_v2 CDS 1052827 1053105 . + 0 Mb0967 HYPOTHETICAL PROTEIN Mb0967, -, len: 92 aa. Equivalent to Rv0942, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 92 aa overlap). Hypothetical unknown protein. X2BGM0 No conserved hypotheticals Rv0942 NC_002945.3 Mycobrowser_v2 CDS 1076635 1077117 . - 0 Mb0989c HYPOTHETICAL PROTEIN Mb0989c, -, len: 160 aa. Equivalent to Rv0964c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 160 aa overlap). Hypothetical unknown protein. Equivalent to AAK45241.1 from Mycobacterium tuberculosis strain CDC1551 (138 aa) but longer 22 aa. X2BGQ4 No conserved hypotheticals Rv0964c NC_002945.3 Mycobrowser_v2 CDS 1536425 1537246 . + 0 Mb1401 HYPOTHETICAL PROTEIN Mb1401, -, len: 273 aa. Equivalent to Rv1366, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Hypothetical unknown protein. X2BHW3,P64834 No conserved hypotheticals Rv1366 NC_002945.3 Mycobrowser_v2 CDS 1589812 1590285 . + 0 Mb1454 unknown protein Mb1454, -, len: 157 aa. Equivalent to Rv1419, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 157 aa overlap). Hypothetical unknown protein. X2BHK4,P64850 No conserved hypotheticals Rv1419 NC_002945.3 Mycobrowser_v2 CDS 2194652 2195266 . - 0 Mb1993c HYPOTHETICAL PROTEIN Mb1993c, -, len: 204 aa. Equivalent to Rv1958c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Hypothetical unknown protein. Q7TZ74 No conserved hypotheticals Rv1958c NC_002945.3 Mycobrowser_v2 CDS 1676068 1677375 . + 0 Mb1527 PROBABLE MEMBRANE PROTEIN Mb1527, -, len: 435 aa. Equivalent to Rv1490, len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 435 aa overlap). Probable membrane protein. X2BIJ5,P64858 No cell wall and cell processes Rv1490 NC_002945.3 Mycobrowser_v2 CDS 1730932 1731159 . + 0 Mb1572 HYPOTHETICAL PROTEIN Mb1572, -, len: 75 aa. Equivalent to Rv1545, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Hypothetical unknown protein. X2BIN7 No conserved hypotheticals Rv1545 NC_002945.3 Mycobrowser_v2 CDS 1737503 1739446 . + 0 Mb1576 fadD11 probable fatty-acid-coa ligase fadd11 (fatty-acid-coa synthetase) (fatty-acid-coa synthase) Mb1576, fadD11, len: 647 aa. Equivalent to Rv1549 (fadD11') and Rv1550 (fadD11), len: 175 aa and 571 aa,from Mycobacterium tuberculosis strain H37Rv, (100% identity in 167 aa overlap and 99.8% identity in 470 aa overlap). Possible fadD11', fatty-acid-CoA synthetase (EC 6.2.1.-), similar to the N-terminus of many fatty-acid CoA synthetases e.g. NP_147860.1|NC_000854 long-chain-fatty-acid--CoA ligase from Aeropyrum pernix (651 aa); P31685|4CL2_SOLTU 4-coumarate--CoA ligase 2 (EC 6.2.1.12) from Solanum tuberosum (Potato) (545 aa), FASTA scores: opt: 168, E(): 4.4e-06, (30.4% identity in 112 aa overlap); etc. Possible frameshift with respect to next ORF Rv1550|MTCY48.15c but we can find no sequence error to account for this. Probable fadD11, fatty-acid-CoA synthetase (EC 6.2.1.-), similar, except in N-terminus, to many e.g. SC6A5.39|T35430 probable long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) from Streptomyces coelicolor (612 aa); NP_301672.1|NC_002677 putative long-chain-fatty-acid-CoA ligase from Mycobacterium leprae (600 aa); P44446|LCFH_HAEIN putative long-chain-fatty-acid-CoA ligase from Haemophilus influenzae (607 aa), FASTA scores: opt: 762, E(): 2.3e-38,(34.4% identity in 436 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis, a two single base insertions (*-c and *-c) lead to a single product. Q7TZX2 No lipid metabolism Rv1549 NC_002945.3 Mycobrowser_v2 CDS 1760226 1760510 . - 0 Mb1594c probable hypothetical membrane protein Mb1594c, -, len: 94 aa. Equivalent to Rv1567c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Probable membrane protein. Q7VEY4 No cell wall and cell processes Rv1567c NC_002945.3 Mycobrowser_v2 CDS 1768675 1768989 . - 0 Mb1605c Probable phiRv1 phage protein Mb1605c, -, len: 104 aa. Equivalent to Rv1579c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 104 aa overlap). Probable phiRv1 phage protein (see citation below). Q7VEX7 No insertion seqs and phages Rv1579c NC_002945.3 Mycobrowser_v2 CDS 1881121 1881483 . + 0 Mb1696 HYPOTHETICAL PROTEIN Mb1696, -, len: 120 aa. Equivalent to Rv1669, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 120 aa overlap). Hypothetical unknown protein. Q7TZU1 No conserved hypotheticals Rv1669 NC_002945.3 Mycobrowser_v2 tRNA 1931953 1932026 . + 0 proT proT tRNA-Pro proT, len: 74 nt. Equivalent to proT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro, anticodon ggg. No NC_002945.3 Mycobrowser_v2 CDS 1935972 1936391 . - 0 Mb1753c HYPOTHETICAL PROTEIN Mb1753c, -, len: 139 aa. Equivalent to Rv1724c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 139 aa overlap). Hypothetical unknown protein. Q7TZQ0 No conserved hypotheticals Rv1724c NC_002945.3 Mycobrowser_v2 CDS 2049896 2049976 . + 0 Mb1847 CONSERVED HYPOTHETICAL PROTEIN Mb1847, -, len: 26 aa. Equivalent to Rv1816A, len: 26 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 26 aa overlap). Conserved hypothetical protein. Q7TZH2 No Rv1816A NC_002945.3 Mycobrowser_v2 CDS 2113893 2114579 . + 0 Mb1905 unknown protein Mb1905, -, len: 228 aa. Equivalent to Rv1874, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Hypothetical unknown protein. Q7TZE2 No conserved hypotheticals Rv1874 NC_002945.3 Mycobrowser_v2 CDS 2192857 2193378 . - 0 Mb1989c HYPOTHETICAL PROTEIN Mb1989c, -, len: 173 aa. Equivalent to Rv1954c,len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 173 aa overlap). Hypothetical unknown protein, end overlaps next ORF upstream, Rv1955 (MTCY09F9.09c). Q7TZ78 No conserved hypotheticals Rv1954c NC_002945.3 Mycobrowser_v2 CDS 2314923 2315174 . - 0 Mb2101c conserved hypothetical protein Mb2101c, -, len: 83 aa. Equivalent to Rv2076c, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Unknown, questionable ORF X2BJN0,P64932 No conserved hypotheticals Rv2076c NC_002945.3 Mycobrowser_v2 CDS 2693723 2694028 . - 0 Mb2452c Mb2452c, -, len: 101 aa. Equivalent to the second part of oxyR' pseudogene (see citation below). No NC_002945.3 Mycobrowser_v2 CDS 2922521 2922883 . + 0 Mb2661 HYPOTHETICAL PROTEIN Mb2661, -, len: 120 aa. Equivalent to Rv2628, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 120 aa overlap). Hypothetical unknown protein. Q7TY70 No conserved hypotheticals Rv2628 NC_002945.3 Mycobrowser_v2 CDS 2954688 2956604 . - 0 Mb2701c dxs1 PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) Mb2701c, dxs1, len: 638 aa. Equivalent to Rv2682c,len: 638 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 638 aa overlap). Probable dxs1,1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-),equivalent to Q50000|DXS_MYCLE|TKTB|ML1038 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE from Mycobacterium leprae (643 aa), FASTA scores: opt: 3635, E(): 5.6e-209,(86.4% identity in 632 aa overlap). Also highly similar to other Q9X7W3|DXS_STRCO|DXS|SC6A5.17 from Streptomyces coelicolor (656 aa), FASTA scores: opt: 2501, E(): 2e-141,(61.3% identity in 623 aa overlap); Q9K971|DXS_BACHD|DXS|BH2779 from Bacillus halodurans (629 aa), FASTA scores: opt: 1612, E(): 1.8e-88, (41.35% identity in 619 aa overlap); P77488|DXS_ECOLI|DXS|B0420 from Escherichia coli strain K12 (619 aa), FASTA scores: opt: 1511, E(): 1.8e-82, (39.5% identity in 625 aa overlap); etc. Also similar to O50408|Rv3379c|MTV004.37c from Mycobacterium tuberculosis (536 aa). BELONGS TO THE TRANSKETOLASE FAMILY. DXS SUBFAMILY. COFACTOR: THIAMINE PYROPHOSPHATE. Note that previously known as dxs. X2BLJ2,P0A555 No NC_002945.3 Mycobrowser_v2 CDS 2976836 2977093 . - 0 Mb2725c HYPOTHETICAL PROTEIN Mb2725c, -, len: 85 aa. Equivalent to Rv2706c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Hypothetical unknown protein. Q7TY24 No conserved hypotheticals Rv2706c NC_002945.3 Mycobrowser_v2 CDS 2999178 2999654 . + 0 Mb2749 HYPOTHETICAL PROTEIN Mb2749, -, len: 158 aa. Equivalent to Rv2730, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Hypothetical unknown protein. Q7TY08 No conserved hypotheticals Rv2730 NC_002945.3 Mycobrowser_v2 CDS 3085535 3085909 . - 0 Mb2846c HYPOTHETICAL PROTEIN Mb2846c, -, len: 124 aa. Equivalent to Rv2822c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Hypothetical unknown protein. Q7TXS5 No conserved hypotheticals Rv2822c NC_002945.3 Mycobrowser_v2 CDS 3134338 3134601 . + 0 Mb2891 relg toxin relg Mb2891, -, len: 87 aa. Equivalent to Rv2866, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Conserved hypothetical protein, similar to O50461|Rv1246c|MTV006.18c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 aa), FASTA scores: opt: 290, E(): 3.6e-16, (54.1% identity in 85 aa overlap). Q7TXN8 No virulence, detoxification, adaptation Rv2866 NC_002945.3 Mycobrowser_v2 CDS 3332373 3333002 . + 0 Mb3041 lpqA PROBABLE LIPOPROTEIN LPQA Mb3041, lpqA, len: 209 aa. Equivalent to Rv3016,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable lpqA,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TXF9 No cell wall and cell processes Rv3016 NC_002945.3 Mycobrowser_v2 CDS 3334888 3334974 . - 0 Mb3044c PE27A pe family protein pe27a Mb3044c, PE27A, len: 28 aa. Equivalent to Rv3018A,len: 28 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 28 aa overlap). Member of M. tuberculosis PE family, most similar to Rv0285 (102 aa),FASTA scores: opt: 147, E(): 3.5e-05, (92.85% identity in 28 aa overlap); etc. Q7VEL4 No NC_002945.3 Mycobrowser_v2 tRNA 3388387 3388459 . - 0 alaU alaU tRNA-Ala alaU, len: 73 nt. Equivalent to alaU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon ggc. No NC_002945.3 Mycobrowser_v2 CDS 3433608 3434048 . + 0 Mb3135 HYPOTHETICAL PROTEIN Mb3135, -, len: 146 aa. Equivalent to Rv3108, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Hypothetical unknown protein. Q7TX85 No conserved hypotheticals Rv3108 NC_002945.3 Mycobrowser_v2 CDS 3445580 3445894 . - 0 Mb3149c HYPOTHETICAL PROTEIN Mb3149c, -, len: 104 aa. Equivalent to Rv3126c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Hypothetical unknown protein. Shortened version of MTCY164.36c, avoiding overlap. Q7TX75 No conserved hypotheticals Rv3126c NC_002945.3 Mycobrowser_v2 CDS 3498133 3498615 . - 0 Mb3197c HYPOTHETICAL PROTEIN Mb3197c, -, len: 160 aa. Equivalent to Rv3172c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein. Q7TX40 No conserved hypotheticals Rv3172c NC_002945.3 Mycobrowser_v2 CDS 3521231 3521431 . - 0 Mb3219c unknown protein Mb3219c, -, len: 66 aa. Equivalent to Rv3196A, len: 66 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 66 aa overlap). Hypothetical unknown protein. Q7TX18 No conserved hypotheticals Rv3196A NC_002945.3 Mycobrowser_v2 CDS 3576849 3577691 . - 0 Mb3271c unknown protein Mb3271c, -, len: 280 aa. Equivalent to Rv3243c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Hypothetical unknown protein. Q7TWX0 No conserved hypotheticals Rv3243c NC_002945.3 Mycobrowser_v2 CDS 3565900 3566541 . + 0 Mb3263 HYPOTHETICAL ALANINE ARGININE PROLINE RICH PROTEIN Mb3263, -, len: 213 aa. Equivalent to Rv3235, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Hypothetical unknown ala-, arg-, pro-rich protein. Q7TWX7 No conserved hypotheticals Rv3235 NC_002945.3 Mycobrowser_v2 CDS 3741366 3742256 . + 0 Mb3408 echA18 probable enoyl-coa hydratase (fragment) echa18.1 (enoyl hydrase) (unsaturated acyl-coa hydratase) (crotonase) Mb3408, echA18, len: 296 aa. Equivalent to Rv3373 and Rv3374, len: 213 aa and 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 213 aa overlap and 100.0% identity in 82 aa overlap). Rv3373: Probable echA18, enoyl-CoA hydratase (EC 4.2.1.17),similar to others e.g. P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 423,E(): 3.4e-20, (37.95% identity in 174 aa overlap); Q9X7Q4|SC5F2A.31c from Streptomyces coelicolor (257 aa),FASTA scores: opt: 399, E(): 1.2e-18, (45.05% identity in 171 aa overlap); BAB52005|MLL5584 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 385,E(): 9.6e-18, (41.95% identity in 174 aa overlap); etc. Also some similarity to 3-HYDROXYBUTYRYL-COA DEHYDRATASES (EC 4.2.1.55) e.g. P52046|CRT_CLOAB from Clostridium acetobutylicum (261 aa), FASTA scores: opt: 414, E(): 1.3e-19, (38.3% identity in 175 aa overlap). And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE (257 aa), FASTA scores: opt: 365, E(): 1.9e-16, (39.1% identity in 174 aa overlap). BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Note that this homology extends across the stop codon and directly into the next ORF MTV004.29, suggesting a possible readthrough of the TGA stop codon. Rv3374: Probable echA18', enoyl-CoA hydratase C-terminus (EC 4.2.1.17), similar to the C-terminus of several enoyl-CoA hydratases e.g. Q9I5I4|PA0745 from Pseudomonas aeruginosa (272 aa), FASTA scores: opt: 123, E(): 0.13, (34.55% identity in 81 aa overlap); P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 115,E(): 0.45, (32.95% identity in 82 aa overlap); Q9I002|PA2841 from Pseudomonas aeruginosa (263 aa), FASTA scores: opt: 108, E(): 1.4, (30.95% identity in 84 aa overlap); etc. Also some similarity to C-terminus of O29956|AF0285 3-HYDROXYACYL-COA DEHYDROGENASE from Archaeoglobus fulgidus (658 aa), FASTA scores: opt: 116,E(): 0.81, (34.15% identity in 82 aa overlap); and other enzymes. And similar to other hydratases from M. tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE (257 aa), FASTA scores: opt: 111, E(): 0.83, (36.05% identity in 86 aa overlap). This homology extends across the upstream TGA stop codon into the upstream ORF MTV004.28, suggesting possible readthrough of the previous stop codon. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis, a single base transversion (t-g) leads to a single product. Q7TWL6 No lipid metabolism Rv3373 NC_002945.3 Mycobrowser_v2 CDS 3807367 3807678 . - 0 Mb3470c HYPOTHETICAL PROTEIN Mb3470c, -, len: 103 aa. Equivalent to Rv3440c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Hypothetical unknown protein. Q7TWI0 No conserved hypotheticals Rv3440c NC_002945.3 Mycobrowser_v2 CDS 3855513 3856091 . + 0 Mb3521 unknown protein Mb3521, -, len: 192 aa. Equivalent to Rv3491, len: 192 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 192 aa overlap). Hypothetical unknown protein. No significant homology with other proteins. Q7TWE0 No conserved hypotheticals Rv3491 NC_002945.3 Mycobrowser_v2 CDS 3911032 3912159 . - 0 Mb3561c HYPOTHETICAL PROTEIN Mb3561c, -, len: 375 aa. Equivalent to Rv3531c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Hypothetical unknown protein. Q7TWA0 No conserved hypotheticals Rv3531c NC_002945.3 Mycobrowser_v2 CDS 3997011 3997172 . - 0 Mb3643c HYPOTHETICAL PROTEIN Mb3643c, -, len: 53 aa. Equivalent to Rv3613c, len: 53 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 53 aa overlap). Hypothetical unknown protein. Q7TW36 No conserved hypotheticals Rv3613c NC_002945.3 Mycobrowser_v2 tRNA 4018602 4018674 . - 0 thrU thrU tRNA-Thr thrU, len: 73 nt. Equivalent to thrU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Thr, anticodon cgt. No NC_002945.3 Mycobrowser_v2 tRNA 4063888 4063961 . + 0 proY proY tRNA-Pro proY, len: 74 nt. Equivalent to proY, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro, anticodon cgg. No NC_002945.3 Mycobrowser_v2 tRNA 4158876 4158962 . - 0 serU serU tRNA-Ser serU, len: 87 nt. Equivalent to serU, len: 87 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 87 nt overlap). tRNA-Ser, anticodon tga. No NC_002945.3 Mycobrowser_v2 CDS 4220269 4220604 . + 0 Mb3849 unknown protein Mb3849, -, len: 111 aa. Equivalent to Rv3819, len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Hypothetical unknown protein. Contains PS00012 Phosphopantetheine attachment site. Q7TVL4 No conserved hypotheticals Rv3819 NC_002945.3 Mycobrowser_v2 CDS 4274219 4274545 . + 0 Mb3891 HYPOTHETICAL PROTEIN Mb3891, -, len: 108 aa. Equivalent to Rv3861, len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Hypothetical unknown protein. Q7TVH5 No conserved hypotheticals Rv3861 NC_002945.3 Mycobrowser_v2 CDS 4242030 4242512 . + 0 Mb3861 HYPOTHETICAL PROTEIN Mb3861, -, len: 160 aa. Equivalent to Rv3831, len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein. Q7TVK2 No conserved hypotheticals Rv3831 NC_002945.3 Mycobrowser_v2 CDS 4255554 4255913 . + 0 Mb3875 HYPOTHETICAL PROTEIN Mb3875, -, len: 119 aa. Equivalent to Rv3845, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical unknown protein. Contains PS01137 Hypothetical YBL055c/yjjV family signature 1. Q7TVJ0 No conserved hypotheticals Rv3845 NC_002945.3 Mycobrowser_v2 CDS 4321326 4321856 . - 0 Mb3932c HYPOTHETICAL PROTEIN Mb3932c, -, len: 176 aa. Equivalent to Rv3902c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Hypothetical unknown protein. Q7TVD9 No conserved hypotheticals Rv3902c NC_002945.3 Mycobrowser_v2 CDS 4334830 4335594 . + 0 Mb3943 HYPOTHETICAL ALANINE RICH PROTEIN Mb3943, -, len: 254 aa. Equivalent to Rv3912, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Hypothetical unknown ala-rich protein. Q7TVC9 No conserved hypotheticals Rv3912 NC_002945.3 Mycobrowser_v2 CDS 1282215 1282856 . - 0 Mb1185c HYPOTHETICAL PROTEIN Mb1185c, -, len: 213 aa. Equivalent to Rv1154c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 213 aa overlap). Hypothetical unknown protein, start uncertain. Q7U0I8 No conserved hypotheticals Rv1154c NC_002945.3 Mycobrowser_v2 CDS 2189658 2190059 . + 0 Mb1982 HYPOTHETICAL PROTEIN Mb1982, -, len: 133 aa. Equivalent to Rv1947, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Hypothetical unknown protein Q7TZ85 No conserved hypotheticals Rv1947 NC_002945.3 Mycobrowser_v2 CDS 2190348 2190698 . - 0 Mb1983c HYPOTHETICAL PROTEIN Mb1983c, -, len: 116 aa. Equivalent to Rv1948c,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 116 aa overlap). Hypothetical unknown protein Q7TZ84 No conserved hypotheticals Rv1948c NC_002945.3 Mycobrowser_v2 CDS 3307885 3309222 . + 0 Mb3018 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3018, -, len: 445 aa. Equivalent to Rv2994, len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug. C-terminal part highly similar to O33118|MLCB637.27c HYPOTHETICAL 14.7 KDA PROTEIN (probable pseudogene product) from Mycobacterium leprae (134 aa), FASTA scores: opt: 483, E(): 2.7e-21, (60.9% identity in 138 aa overlap). Also similar to various transporters e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 289, E(): 1.3e-09,(26.05% identity in 399 aa overlap); O30210|AF0025 CYANATE TRANSPORT PROTEIN from Archaeoglobus fulgidus (393 aa),FASTA scores: opt: 281, E(): 3.7e-09, (24.05% identity in 399 aa overlap); Q9RI35|SCJ12.25C PUTATIVE NITRATE/NITRITE TRANSPORTER from Streptomyces coelicolor (412 aa), FASTA scores: opt: 264, E(): 3.8e-08, (24.95% identity in 409 aa overlap); Q9A5N5|CC2412 MAJOR FACILITATOR FAMILY TRANSPORTER from Caulobacter crescentus (405 aa), FASTA scores: opt: 263, E(): 4.3e-08, (27.55% identity in 399 aa overlap); etc. First start taken; similarity to P21191|NORA_STAAU QUINOLONE RESISTANCE PROTEIN from Staphylococcus aureus (388 aa) suggests alternative start at 7319 but then no positively charged aa before first transmembrane segment. Q7TVB6 No cell wall and cell processes Rv2994 NC_002945.3 Mycobrowser_v2 CDS 1355490 1355717 . + 0 Mb1243 conserved protein Mb1243, -, len: 75 aa. Equivalent to Rv1211, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Conserved hypothetical protein, similar to Q49958|U1756N Mycobacterium leprae (75 aa), FASTA scores: opt: 460, E(): 0, (90.7% identity in 75 aa overlap). Q7U0D8 No conserved hypotheticals Rv1211 NC_002945.3 Mycobrowser_v2 CDS 2490838 2491428 . - 0 Mb2264c unknown protein Mb2264c, len: 196 aa. Equivalent to Rv2240c len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 196 aa overlap). Unknown protein. Start changed since first submission (-69 aa). X2BKI1 No conserved hypotheticals Rv2240c NC_002945.3 Mycobrowser_v2 tRNA 2489746 2489817 . - 0 valV valV tRNA-Val valV, len: 72 nt. Equivalent to valV, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Val, anticodon tac. No NC_002945.3 Mycobrowser_v2 CDS 2489499 2489735 . - 0 Mb2261A Conserved protein Mb2261A, len: 78 aa. Equivalent to Rv2237A len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 78 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BKJ1 No conserved hypotheticals Rv2237A NC_002945.3 Mycobrowser_v2 CDS 4151494 4152069 . - 0 Mb3796c HYPOTHETICAL LEUCINE RICH PROTEIN Mb3796c, -, len: 191 aa. Equivalent to Rv3770c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 191 aa overlap). Hypothetical unknown leu-rich protein. Q7TVQ4 No conserved hypotheticals Rv3770c NC_002945.3 Mycobrowser_v2 tRNA 11112 11184 . + 0 alaT alaT tRNA-Ala alaT, len: 73 nt. Equivalent to alaT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon tgc. No NC_002945.3 Mycobrowser_v2 CDS 3083926 3084834 . - 0 Mb2844c HYPOTHETICAL PROTEIN Mb2844c, -, len: 302 aa. Equivalent to Rv2820c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Hypothetical unknown protein. Q7TXS7 No conserved hypotheticals Rv2820c NC_002945.3 Mycobrowser_v2 CDS 11874 12311 . - 0 Mb0008c POSSIBLE MEMBRANE PROTEIN Mb0008c, -, len: 145 aa. Equivalent to Rv0008c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible membrane protein. X2BDR6,P59977 No cell wall and cell processes Rv0008c NC_002945.3 Mycobrowser_v2 CDS 2089903 2090538 . + 0 Mb1882 ureF Urease accessory protein uref Mb1882, ureF, len: 211 aa. Equivalent to Rv1851,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). ureF, urease accessory protein. Identical to UREF_MYCTU|P50050 from M. tuberculosis. X2BJ66,Q7VET6 No intermediary metabolism and respiration Rv1851 NC_002945.3 Mycobrowser_v2 CDS 396377 397117 . - 0 Mb0337c HYPOTHETICAL PROTEIN Mb0337c, -, len: 246 aa. Equivalent to Rv0330c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Hypothetical unknown protein. Q7U289 No conserved hypotheticals Rv0330c NC_002945.3 Mycobrowser_v2 CDS 1302680 1303120 . + 0 Mb1204 CONSERVED HYPOTHETICAL PROTEIN Mb1204, -, len: 146 aa. Equivalent to Rv1171, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Conserved hypothetical protein, possibly transmembrane protein. Start has been changed since first submission. Q7U0H1 No conserved hypotheticals Rv1171 NC_002945.3 Mycobrowser_v2 CDS 33566 33778 . + 0 Mb0032 possible remnant of a transposase Mb0032, -, len: 70 aa. Equivalent to Rv0031, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 70 aa overlap). Possible remnant of a transposase, showing partial similarity to mycobacterial transposases in a short overlap, e.g. Rv2791c|MTV002_57 (459 aa), FASTA score: (72.2% identity in 36 aa overlap); Rv2885c, Rv2978c, Rv3827c, etc. Q7U2Z6 No insertion seqs and phages Rv0031 NC_002945.3 Mycobrowser_v2 CDS 51812 52681 . - 0 Mb0049c POSSIBLE MEMBRANE PROTEIN Mb0049c, -, len: 289 aa. Equivalent to Rv0048c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 289 aa overlap). Possible membrane protein. Q7U2Y7 No cell wall and cell processes Rv0048c NC_002945.3 Mycobrowser_v2 CDS 1716486 1717052 . + 0 Mb1558 conserved protein Mb1558, -, len: 188 aa. Equivalent to Rv1531, len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 188 aa overlap). Conserved hypothetical protein, similar to Rv0464c|MTV038.08c (190 aa), FASTA scores: E(): 4.8e-10, (30.9% identity in 175 aa overlap). Q7TZX7 No conserved hypotheticals Rv1531 NC_002945.3 Mycobrowser_v2 CDS 1953102 1953314 . + 0 Mb1769 vapb34 possible antitoxin vapb34 Mb1769, -, len: 70 aa. Equivalent to Rv1740, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 70 aa overlap). Conserved hypothetical protein, highly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96913|Rv0623|MTCY20H10.04 (84 aa), (73.5% identity in 68 aa overlap); P71998|Rv1740 (70 aa), and O07770|Rv0608 (81 aa). Q7TZN6 No virulence, detoxification, adaptation Rv1740 NC_002945.3 Mycobrowser_v2 CDS 2524286 2524585 . + 0 Mb2294 CONSERVED HYPOTHETICAL PROTEIN Mb2294, -, len: 99 aa. Equivalent to Rv2271, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein AAK01340.1|AF265275_3 (AF265275) from uncultured organism Pu8 (104 aa) E= 4e-10, (34% identity in 91 aa overlap) X2BKL0 No conserved hypotheticals Rv2271 NC_002945.3 Mycobrowser_v2 CDS 3817453 3818820 . + 0 Mb3479 mycp4 probable membrane-anchored mycosin mycp4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) Mb3479, -, len: 455 aa. Equivalent to Rv3449, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 455 aa overlap). Probable secreted serine protease (EC 3.4.21.-). Similar to hypothetical unknowns or proteases from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK48366|MT3998 SUBTILASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (411 aa), FASTA scores: opt: 747, E(): 3.5e-33,(45.65% identity in 416 aa overlap); O05461|Rv3883c|MTCY15F10.29 HYPOTHETICAL PROTEIN (446 aa),FASTA scores: opt: 747, E(): 3.8e-33, (45.45% identity in 451 aa overlap); O53695|Rv0291|MTV035.19 HYPOTHETICAL PROTEIN (461 aa), FASTA scores: opt: 660, E(): 1.9e-28,(44.0% identity in 457 aa overlap); etc. And similar to hypothetical proteases from Mycobacterium leprae e.g. O33076|MLCB628.04|ML0041 HYPOTHETICAL 45.7 KDA PROTEIN (PROBABLE SECRETED PROTEASE) (446 aa), FASTA scores: opt: 683, E(): 1.1e-29, (43.8% identity in 450 aa overlap); Q9CD36|ML2528 PUTATIVE PROTEASE (475 aa), FASTA scores: opt: 608, E(): 1.3e-25, (43.0% identity in 451 aa overlap); Q9CBV3|ML1538 POSSIBLE PROTEASE (567 aa), FASTA scores: opt: 389, E(): 9.7e-14, (33.8% identity in 562 aa overlap); etc. Also some similarity to other proteases from several organisms e.g. O31788|APRX ALKALINE SERINE PROTEASE from Bacillus subtilis (442 aa), FASTA scores: opt: 296, E(): 8.3e-09, (29.4% identity in 313 aa overlap); O86650|SC3C3.17c PUTATIVE SECRETED SERINE PROTEASE from Streptomyces coelicolor (450 aa), FASTA scores: opt: 279, E(): 7e-08, (33.55% identity in 343 aa overlap); Q9KBJ7|APRX|BH193 INTRACELLULAR ALKALINE SERINE PROTEASE from Bacillus halodurans (444 aa), FASTA scores: opt: 257, E(): 1.1e-06, (28.65% identity in 335 aa overlap); O86642|SC3C3.08 SERINE PROTEASE from Streptomyces coelicolor (413 aa), FASTA scores: opt: 243,E(): 5.7e-06, (38.25% identity in 387 aa overlap); etc. Has putative signal peptide at N-terminus and hydrophobic stretch at C-terminus. Contains three signatures typical of subtilase family: aspartic acid active site (PS00136),histidine active site (PS00137), serine active site (PS00138). Q7TWH3 No intermediary metabolism and respiration Rv3449 NC_002945.3 Mycobrowser_v2 CDS 3935900 3937957 . + 0 Mb3584 fdxB POSSIBLE ELECTRON TRANSFER PROTEIN FDXB Mb3584, fdxB, len: 685 aa. Equivalent to Rv3554,len: 685 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 685 aa overlap). Possible fdxB,two-domain protein, with ferredoxin reductase electron transfer component in C-terminal part (EC 1.-.-.-) and unknown function in N-terminal part. Indeed, N-terminal end is similar to O85832 HYPOTHETICAL 36.1 KDA PROTEIN from Sphingomonas aromaticivorans strain F199 (catabolic plasmid pNL1) (309 aa), FASTA scores: opt: 615, E(): 2.5e-30, (33.1% identity in 311 aa overlap); and P73428|SLL1468 HYPOTHETICAL 36.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (312 aa), FASTA scores: opt: 317, E(): 4.5e-12, (30.2% identity in 268 aa overlap). And C-terminal end is similar to Q9F9U6|PAAE protein involved in aerobic phenylacetate metabolism from Azoarcus evansii (360 aa), FASTA scores: opt: 935, E(): 7e-50, (43.85% identity in 351 aa overlap); CAC44653|PAAE|SCBAC17A6.08 PUTATIVE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Streptomyces coelicolor (368 aa), FASTA scores: opt: 93, E(): 9.5e-50,(41.95% identity in 372 aa overlap); Q9FA57|PACI FERREDOXIN from Azoarcus evansii (360 aa), FASTA scores: opt: 925, E(): 2.9e-49, (43.3% identity in 351 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Escherichia coli strains K12 and W (356 aa), FASTA scores: opt: 910, E(): 2.4e-48, (43.05% identity in 353 aa overlap); Q9APJ6|PAAE ELECTRON TRANSFER PROTEIN (FRAGMENT) from Hyphomicrobium chloromethanicum (241 aa), FASTA scores: opt: 404, E(): 1.7e-17, (35.45% identity in 234 aa overlap); BAB51608|MLL5100 FERREDOXIN from Rhizobium loti (Mesorhizobium loti) (365 aa), FASTA scores: opt: 316,E(): 5.8e-12, (28.95% identity in 349 aa overlap); etc. C-terminus also similar to P96853|Rv3571|MTCY06G11.18 PUTATIVE ELECTRON TRANSFER PROTEIN from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 450, E(): 3.6e-20, (32.95% identity in 358 aa overlap). Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. BELONGS TO THE 2FE2S PLANT-TYPE FERREDOXIN FAMILY. COFACTOR: BINDS A 2FE-2S CLUSTER (BY SIMILARITY). Q7TW80 No intermediary metabolism and respiration Rv3554 NC_002945.3 Mycobrowser_v2 CDS 2523652 2524179 . + 0 Mb2293 lppN Probable lipoprotein lppN Mb2293, lppN, len: 175 aa. Equivalent to Rv2270,len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 175 aa overlap). Probable lppN,lipoprotein; has appropriately positioned prokaryotic membrane lipoprotein attachment site PS00013. X2BK82,Q7VEM3 No cell wall and cell processes Rv2270 NC_002945.3 Mycobrowser_v2 CDS 1561772 1562104 . + 0 Mb1425 rpoZ PROBABLE DNA-DIRECTED RNA POLYMERASE (OMEGA CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE OMEGA SUBUNIT) Mb1425, rpoZ, len: 110 aa. Equivalent to Rv1390,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Probable rpoZ,DNA-directed RNA polymerase omega chain (EC 2.7.7.6). BELONGS TO THE RNA POLYMERASE OMEGA CHAIN FAMILY. X2BHY4,P66722 No information pathways Rv1390 NC_002945.3 Mycobrowser_v2 CDS 3303419 3304279 . - 0 Mb3014c HYPOTHETICAL PROTEIN Mb3014c, -, len: 286 aa. Equivalent to Rv2990c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Hypothetical unknown protein. Q7TXH4 No conserved hypotheticals Rv2990c NC_002945.3 Mycobrowser_v2 CDS 1171487 1172602 . - 0 Mb1077c HYPOTHETICAL PROTEIN Mb1077c, -, len: 371 aa. Equivalent to Rv1048c,len: 371 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 371 aa overlap). Hypothetical unknown protein. Q7U0S8 No conserved hypotheticals Rv1048c NC_002945.3 Mycobrowser_v2 CDS 3323259 3323882 . + 0 Mb3033 HYPOTHETICAL PROTEIN Mb3033, -, len: 207 aa. Equivalent to Rv3008, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Hypothetical unknown protein. Start uncertain. Q7TXG3 No conserved hypotheticals Rv3008 NC_002945.3 Mycobrowser_v2 CDS 477698 478339 . - 0 Mb0404c POSSIBLE SECRETED PROTEIN Mb0404c, -, len: 213 aa. Equivalent to Rv0398c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Possible secreted protein, sharing no homology with other proteins. Has potential signal sequence with hydrophobic stretch from aa 7-25. Q7U232 No cell wall and cell processes Rv0398c NC_002945.3 Mycobrowser_v2 CDS 3624111 3624524 . - 0 Mb3316c usfY PUTATIVE PROTEIN USFY Mb3316c, usfY, len: 137 aa. Equivalent to Rv3288c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). usfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins. P96893 No NC_002945.3 Mycobrowser_v2 CDS 364873 365094 . + 0 Mb0308 vapb2 possible antitoxin vapb2 Mb0308, -, len: 73 aa. Equivalent to Rv0300, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical protein, similar to Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa), FASTA scores: opt: 84, E(): 8.3, (39.5% identity in 38 aa overlap). Q7U2B7 No virulence, detoxification, adaptation Rv0300 NC_002945.3 Mycobrowser_v2 CDS 365091 365516 . + 0 Mb0309 vapc2 possible toxin vapc2 Mb0309, -, len: 141 aa. Equivalent to Rv0301, len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Conserved hypothetical protein, similar to other hypothetical M. tuberculosis proteins e.g. Rv2757c, Rv0229c, Rv2546, etc. Q7U2B6 No virulence, detoxification, adaptation Rv0301 NC_002945.3 Mycobrowser_v2 CDS 262479 263027 . + 0 Mb0225 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0225, -, len: 182 aa. Equivalent to Rv0219, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable conserved transmembrane protein, showing similarity with CAB76992.1|AL159178 putative lipoprotein from Streptomyces coelicolor (163 aa). Q7U2J4 No cell wall and cell processes Rv0219 NC_002945.3 Mycobrowser_v2 CDS 330073 330993 . + 0 Mb0282 CONSERVED HYPOTHETICAL PROTEIN Mb0282, -, len: 306 aa. Equivalent to Rv0276, len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 306 aa overlap). Conserved hypothetical protein, similar to Rv2237|Z70692|MTCY427.18 from Mycobacterium tuberculosis (296 aa), FASTA scores: opt: 874, E(): 0, (49.6% identity in 282 aa overlap). Q7U2E0 No conserved hypotheticals Rv0276 NC_002945.3 Mycobrowser_v2 CDS 457932 458840 . - 0 Mb0388c HYPOTHETICAL PROTEIN Mb0388c, -, len: 302 aa. Equivalent to Rv0381c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Hypothetical unknown protein. Equivalent to AAK44616.1 from Mycobacterium tuberculosis strain CDC1551 (254 aa) but longer 48 aa. Q7U246 No conserved hypotheticals Rv0381c NC_002945.3 Mycobrowser_v2 CDS 2213907 2216222 . - 0 Mb2015c ctpG PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE G CTPG Mb2015c, ctpG, len: 771 aa. Equivalent to Rv1992c,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 771 aa overlap). Probable ctpG, metal cation-transporting P-type ATPase G (transmembrane protein) (EC 3.6.3.-), similar to others, especially cadmium-transporting ATPases (EC 3.6.3.3), e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI PROBABLE CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO PROBABLE CADMIUM-TRANSPORTING ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV PUTATIVE CATION TRANSPORTER P-TYPE ATPASE V (770 aa); Rv1469; Rv0092; etc. Contains PS00435 Peroxidases proximal heme-ligand signature and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. X2BJ77,P63690 No NC_002945.3 Mycobrowser_v2 CDS 2485355 2485531 . - 0 Mb2256B vapB16 Possible antitoxin VapB16 Mb2256B, len: 58 aa. Equivalent to Rv2231B len: 58 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 58 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB16,antitoxin,part of toxin-antitoxin (TA) operon with Rv2231A (See Pandey and Gerdes, 2005). X2BJN5 No virulence, detoxification, adaptation Rv2231B NC_002945.3 Mycobrowser_v2 CDS 843137 843394 . + 0 Mb0769 vapb31 possible antitoxin vapb31 Mb0769, -, len: 85 aa. Equivalent to Rv0748, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, N-terminus similar to N-terminal region of NP_436939.1|NC_003078 HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (75 aa). Also similar to Mycobacterium tuberculosis proteins Rv2871 CONSERVED HYPOTHETICAL PROTEIN (75 aa); Rv1241, Rv2132, Rv3321c,etc. Q7U1D2 No virulence, detoxification, adaptation Rv0748 NC_002945.3 Mycobrowser_v2 CDS 52815 53228 . + 0 Mb0050 CONSERVED HYPOTHETICAL PROTEIN Mb0050, -, len: 137 aa. Equivalent to Rv0049, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein, only equivalent to AL022118|MLCB1913_20 hypothetical protein from Mycobacterium leprae (138 aa), FASTA scores: opt: 768,E(): 0, (83.9% identity in 137 aa overlap). X2BDV4 No conserved hypotheticals Rv0049 NC_002945.3 Mycobrowser_v2 CDS 85218 85607 . - 0 Mb0078c PROBABLE MEMBRANE PROTEIN Mb0078c, -, len: 129 aa. Equivalent to Rv0076c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Probable membrane protein, with membrane-spanning domain at C-terminus. Q7U2W7 No cell wall and cell processes Rv0076c NC_002945.3 Mycobrowser_v2 CDS 843418 843846 . + 0 Mb0770 vapc31 possible toxin vapc31. contains pin domain. Mb0770, -, len: 142 aa. Equivalent to Rv0749, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0749,Rv0277c, Rv2530c, etc. Q7U1D1 No virulence, detoxification, adaptation Rv0749 NC_002945.3 Mycobrowser_v2 CDS 155858 156637 . + 0 Mb0133 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0133, -, len: 259 aa. Equivalent to Rv0128, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Probable conserved transmembrane protein, with some similarity to Rv3064c and other bacterial proteins e.g. AAK85977.1|AE007957|AGR_C_254p from Agrobacterium tumefaciens (206 aa). Q7U2S6 No cell wall and cell processes Rv0128 NC_002945.3 Mycobrowser_v2 CDS 843927 844064 . - 0 Mb0771c HYPOTHETICAL PROTEIN (FRAGMENT) Mb0771c, -, len: 45 aa. Equivalent to Rv0749A, len: 45 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 45 aa overlap). Conserved hypothetical protein (probably gene fragment), similar to part (aa 250-292) of Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 238, E(): 1.9e-13, (79.07% identity in 43 aa overlap). Q7U1D0 No conserved hypotheticals Rv0749A NC_002945.3 Mycobrowser_v2 CDS 844223 844468 . + 0 Mb0772 CONSERVED HYPOTHETICAL PROTEIN Mb0772, -, len: 81 aa. Equivalent to Rv0750, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing almost perfect overlap with C-terminus of Rv0740|MTV041_14 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (175 aa), FASTA scores: (93.8% identity in 81 aa overlap). Possible duplication. Q7U1C9 No conserved hypotheticals Rv0750 NC_002945.3 Mycobrowser_v2 CDS 2507046 2507549 . + 0 Mb2277 Possible secreted unknown protein Mb2277, -, len: 167 aa. Equivalent to Rv2253, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Possible secreted protein; has potential N-terminal signal peptide. Q7VEM9 No cell wall and cell processes Rv2253 NC_002945.3 Mycobrowser_v2 CDS 1776936 1777601 . + 0 Mb1617 PROBABLE TRANSMEMBRANE PROTEIN Mb1617, -, len: 221 aa. Equivalent to Rv1591, len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 221 aa overlap). Probable transmembrane protein, similar to Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical Mycobacterium leprae protein (198 aa), FASTA results: opt: 802, E(): 0, (63.8% identity in 188 aa overlap). X2BID8,P0A5F4 No cell wall and cell processes Rv1591 NC_002945.3 Mycobrowser_v2 CDS 1303128 1304054 . - 0 Mb1205c PE12 pe family protein pe12 Mb1205c, PE12, len: 308 aa. Equivalent to Rv1172c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 308 aa overlap). Member of the Mycobacterium tuberculosis PE family of proteins e.g. P71748|Z81368|MTCY253.25C (361 aa), FASTA scores: opt: 483, E(): 7.8e-22, (46.4% identity in 192 aa overlap). Q7U0H0 No NC_002945.3 Mycobrowser_v2 CDS 1783660 1784418 . + 0 Mb1623 HYPOTHETICAL PROTEIN Mb1623, -, len: 252 aa. Equivalent to Rv1597, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 252 aa overlap). Hypothetical unknown protein. Q7TZW3 No conserved hypotheticals Rv1597 NC_002945.3 Mycobrowser_v2 CDS 2090549 2091223 . + 0 Mb1883 ureG Urease accessory protein ureG Mb1883, ureG, len: 224 aa. Equivalent to Rv1852,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). ureG, urease accessory protein. Identical to UREG_MYCTU|P50051 from M. tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UREG FAMILY. X2BIN9,P0A665 No intermediary metabolism and respiration Rv1852 NC_002945.3 Mycobrowser_v2 CDS 287669 288106 . + 0 Mb0246 vapc24 possible toxin vapc24. contains pin domain. Mb0246, -, len: 145 aa. Equivalent to Rv0240, len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 145 aa overlap). Conserved hypothetical protein, weak similarity with Rv3697c from Mycobacterium tuberculosis (145 aa), FASTA scores: opt: 145, E(): 7.6e-05, (28.0% identity in 143 aa overlap). Q7U2H4 No virulence, detoxification, adaptation Rv0240 NC_002945.3 Mycobrowser_v2 CDS 2129976 2130383 . + 0 Mb1924 conserved protein Mb1924, -, len: 135 aa. Equivalent to Rv1891, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein. Equivalent to MLCB561.09|AL049571 hypothetical protein from Mycobacterium leprae (134 aa),FASTA scores: opt: 800, E(): 0, (79.7% identity in 133 aa overlap). Q7TZC6 No conserved hypotheticals Rv1891 NC_002945.3 Mycobrowser_v2 CDS 300060 300353 . - 0 Mb0256c conserved protein Mb0256c, -, len: 97 aa. Equivalent to Rv0250c, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, equivalent to MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486 hypothetical protein from Mycobacterium leprae (98 aa),FASTA scores: opt: 478, E(): 4.4e-28, (72.6% identity in 95 aa overlap). Also similar to C-terminus of AC44316.1|AL596043|SCBAC31E11.05c hypothetical protein from Streptomyces coelicolor (146 aa). Q7U2G4 No conserved hypotheticals Rv0250c NC_002945.3 Mycobrowser_v2 CDS 1717129 1717563 . - 0 Mb1559c CONSERVED HYPOTHETICAL PROTEIN Mb1559c, -, len: 144 aa. Equivalent to Rv1532c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved hypothetical protein, similar to P20378|YPHR_HALHA Hypothetical 15.6 kd protein from Halobacterium halobium (151 aa), FASTA scores: opt: 152, E():4.5e-05, (30.1% identity in 103 aa overlap). Q7TZX6 No conserved hypotheticals Rv1532c NC_002945.3 Mycobrowser_v2 CDS 1784439 1784849 . - 0 Mb1624c conserved protein Mb1624c, -, len: 136 aa. Equivalent to Rv1598c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Conserved hypothetical protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa). Q7TZW2 No conserved hypotheticals Rv1598c NC_002945.3 Mycobrowser_v2 CDS 2623336 2623653 . + 0 Mb2396 CONSERVED HYPOTHETICAL PROTEIN Mb2396, -, len: 105 aa. Equivalent to Rv2375, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Conserved hypothetical protein, highly similar to only CAC32314|2SCD60.09c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (98 aa), FASTA scores: opt: 425,E(): 5.7e-24, (63.25% identity in 98 aa overlap). Q7TYR0 No conserved hypotheticals Rv2375 NC_002945.3 Mycobrowser_v2 CDS 2351080 2351274 . - 0 Mb2135c pup prokaryotic ubiquitin-like protein pup Mb2135c, -, len: 64 aa. Equivalent to Rv2111c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Conserved hypothetical protein. Highly similar to a hypothetical protein TR:Q53078 (EMBL:U26422) (64 aa) upstream of Rhodococcus proteasome beta-type subunit 1, FASTA scores; opt: 349,E(): 7.3e-25, 84.4% identity in 64 aa overlap X2BK62,Q7TZ12 No intermediary metabolism and respiration Rv2111c NC_002945.3 Mycobrowser_v2 CDS 1215421 1215741 . + 0 Mb1116A CONSERVED HYPOTHETICAL PROTEIN Mb1116A, -, len: 106 aa. Equivalent to Rv1087A,len: 106 aa (fragment), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 106 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of near ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE from Mycobacterium tuberculosis (262 aa), FASTA scores: opt: 200, E(): 1.1e-06, (57.9% identity in 76 aa overlap). Q7U0P6 No cell wall and cell processes Rv1087A NC_002945.3 Mycobrowser_v2 CDS 1443548 1443883 . - 0 Mb1323c CONSERVED HYPOTHETICAL SECRETED PROTEIN Mb1323c, -, len: 111 aa. Equivalent to Rv1291c,len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 111 aa overlap). Conserved hypothetical secreted protein, similar to others in Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU HYPOTHETICAL 11.6 KD PROTEIN (113 aa), FASTA score: opt: 246, E(): 1.7e-09, (40.0% identity in 110 aa overlap); Rv1804c,Rv1810, Rv0622, etc. X2BHW7 No cell wall and cell processes Rv1291c NC_002945.3 Mycobrowser_v2 CDS 2186978 2187568 . - 0 Mb1979c conserved protein Mb1979c, -, len: 196 aa. Equivalent to Rv1944c,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Conserved hypothetical protein, similar to C-terminal part of SCE20.29|AL136058|CAB65585.1 hypothetical protein from Streptomyces coelicolor (338 aa), BLASTP scores,Identities = 37/131 (28%), Positives = 51/131 (38%). Q7TZ88 No conserved hypotheticals Rv1944c NC_002945.3 Mycobrowser_v2 CDS 1405576 1406475 . + 0 Mb1289 udgb probable uracil dna glycosylase, udgb Mb1289, -, len: 299 aa. Equivalent to Rv1259, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 299 aa overlap). Conserved hypothetical protein. Similar to AL109732|SC7H2.04 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 870, E(): 0, (57.1% identity in 231 aa overlap). X2BHG5 No information pathways Rv1259 NC_002945.3 Mycobrowser_v2 CDS 1815436 1815927 . - 0 Mb1654c conserved protein Mb1654c, -, len: 163 aa. Equivalent to Rv1628c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 163 aa overlap). Conserved hypothetical protein, some similarity to others e.g. Q51796 ACAC PROTEIN in Pyrococcus furiosus (136 aa), FASTA scores: opt: 199, E(): 4.6e-06, (34.7% identity in 121 aa overlap). Q7TZV3 No conserved hypotheticals Rv1628c NC_002945.3 Mycobrowser_v2 CDS 2216219 2216491 . - 0 Mb2016c conserved protein Mb2016c, -, len: 90 aa. Equivalent to Rv1993c, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Conserved hypothetical protein, very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). X2BJS9 No conserved hypotheticals Rv1993c NC_002945.3 Mycobrowser_v2 CDS 2375048 2375635 . - 0 Mb2158c conserved protein Mb2158c, -, len: 195 aa. Equivalent to Rv2134c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49789. FASTA best: Q49789 B2126_C3_228, opt: 1192, E( ): 0 (91.1% identity in 192 aa overlap) Q7TZ01 No conserved hypotheticals Rv2134c NC_002945.3 Mycobrowser_v2 CDS 308180 308398 . + 0 Mb0263 CONSERVED HYPOTHETICAL PROTEIN Mb0263, -, len: 72 aa. Equivalent to Rv0257, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Hypothetical protein,orthologue of ML1828A conserved hypothetical protein from Mycobacterium leprae. Replaced Rv0257c (older annotation). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa). Q7U2F8 No conserved hypotheticals Rv0257 NC_002945.3 Mycobrowser_v2 CDS 3673026 3674243 . + 0 Mb3363 dacB1 probable penicillin-binding protein dacb1 (d-alanyl-d-alanine carboxypeptidase) (dd-peptidase) (dd-carboxypeptidase) (pbp) (dd-transpeptidase) (serine-type d-ala-d-ala carboxypeptidase) (d-amino acid hydrolase) Mb3363, dacB1, len: 405 aa. Equivalent to Rv3330,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Probable dacB1,D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), equivalent to Mycobacterium leprae proteins Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (411 aa), FASTA scores: opt: 2066, E(): 2.5e-102, (77.15% identity in 416 aa overlap); Q49917|L308_F1_36 (228 aa), FASTA scores: opt: 1241, E(): 7.9e-59, (78.9% identity in 232 aa overlap) (note that this protein corresponds to C-terminal part of the putative protein encoded by Rv3330, aa 174-405); and Q49921|PBPC (182 aa), FASTA scores: opt: 736, E(): 3.7e-32, (73.95% identity in 169 aa overlap) (note that this protein corresponds to N-terminal part of the putative protein encoded by Rv3330, aa 1-158); note L308_F1_36 (228 aa) and PBPC (182 aa) are two consecutive Mycobacterium leprae ORFs . Also similar to others e.g. Q9FC34|SC4G1.16c PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (413 aa),FASTA scores: opt: 572, E(): 3.4e-23, (33.75% identity in 382 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) from Bacillus subtilis (382 aa), FASTA scores: opt: 422,E(): 2.8e-15, (31.3% identity in 249 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN) from Bacillus halodurans (395 aa), FASTA scores: opt: 421, E(): 3.2e-15, (31.95% identity in 241 aa overlap); etc. Also similar to M. tuberculosis Q10828|Rv2911|MTCY274.43 PROBABLE PENICILLIN-BINDING PROTEIN (BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY) (291 aa), FASTA scores: opt: 746, E(): 1.6e-32,(47.0% identity in 266 aa overlap). Has hydrophobic stretches at both N- and C-termini. Certainly membrane-bound protein. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY. Q7TWP8 No NC_002945.3 Mycobrowser_v2 CDS 932959 933681 . - 0 Mb0859c HYPOTHETICAL PROTEIN Mb0859c, -, len: 240 aa. Equivalent to Rv0836c,len: 217 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 217 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa). Q7U157 No conserved hypotheticals Rv0836c NC_002945.3 Mycobrowser_v2 CDS 2943318 2944094 . + 0 Mb2690 ribD POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) Mb2690, ribD, len: 258 aa. Equivalent to Rv2671,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein incuding diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), highly similar to O05684|MLC1351.23|ML1340 POSSIBLE REDUCTASE from Mycobacterium leprae (268 aa), FASTA scores: opt: 1211,E(): 3e-68, (72.9% identity in 251 aa overlap). Also weakly similar to others e.g. Q9HWX2|RIBD|PA4056 RIBOFLAVIN-SPECIFIC DEAMINASE/REDUCTASE from Pseudomonas aeruginosa (373 aa), FASTA scores: opt: 211, E(): 6.3e-06,(30.1% identity in 216 aa overlap); Q9HQA1|RIBG|VNG1256G RIBOFLAVIN-SPECIFIC DEAMINASE from Halobacterium sp. strain NRC-1 (220 aa), FASTA scores: opt: 202, E(): 1.5e-05, (27.0% identity in 174 aa overlap); O28272|RIB7_ARCFU|AF2007 PUTATIVE 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) (EC 1.1.1.193) from Archaeoglobus fulgidus (219 aa), FASTA scores: opt: 209, E(): 5.4e-06, (24.15% identity in 211 aa overlap); P25539|RIBD_ECOLI|RIBG|B0414 from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 185, E(): 0.00026, (26.7% identity in 221 aa overlap); etc. But also similar to several hydrolases e.g. Q9X825|SC9B1.05 PUTATIVE HYDROLASE from Streptomyces coelicolor (265 aa), FASTA scores: opt: 536, E(): 2.9e-26,(44.25% identity in 235 aa overlap); Q9RKM1|SCD17.10 PUTATIVE BIFUNCTIONAL ENZYME DEAMINASE/REDUCTASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 228,E(): 5.6e-07, (33.5% identity in 188 aa overlap); etc. Equivalent to AAK47060 from Mycobacterium tuberculosis strain CDC1551 (239 aa) but longer 19 aa. SUPPOSED BELONG TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY IN THE N-TERMINAL SECTION; and TO THE HTP REDUCTASE FAMILY IN THE C-TERMINAL SECTION. Q7TY53 No intermediary metabolism and respiration Rv2671 NC_002945.3 Mycobrowser_v2 CDS 400565 401080 . - 0 Mb0342c PE6 pe family protein pe6 Mb0342c, PE6, len: 171 aa. Equivalent to Rv0335c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below); contains short region of similarity to part of the unique N-terminus of the Mycobacterium tuberculosis PGRS family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 219, E(): 1.1e-08, (51.5% identity in 66 aa overlap). Q7U284 No NC_002945.3 Mycobrowser_v2 CDS 2837572 2837817 . - 0 Mb2580c vapb20 possible antitoxin vapb20 Mb2580c, -, len: 81 aa. Equivalent to Rv2550c, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Hypothetical unknown protein. Q7TYB5 No virulence, detoxification, adaptation Rv2550c NC_002945.3 Mycobrowser_v2 CDS 2383021 2383236 . - 0 Mb2166A parD2 Possible antitoxin ParD2 Mb2166A, len: 71 aa. Equivalent to Rv2142A len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible parD2,antitoxin, part of toxin-antitoxin (TA) operon with Rv2142c (See Pandey and Gerdes, 2005). X2BK19 No virulence, detoxification, adaptation Rv2142A NC_002945.3 Mycobrowser_v2 CDS 2426639 2427028 . - 0 Mb2208c CONSERVED HYPOTHETICAL PROTEIN Mb2208c, -, len: 129 aa. Equivalent to Rv2186c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, equivalent to hypothetical Mycobacterium leprae protein ML0888 (135 aa). FASTA scores: ML0888 opt: 704, E(): 2.9e-43; 80.000% identity in 130 aa overlap CAA18694.1| (AL022602). Q7TYY0 No conserved hypotheticals Rv2186c NC_002945.3 Mycobrowser_v2 CDS 990413 993061 . - 0 Mb0914c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR-FAMILY) Mb0914c, -, len: 882 aa. Equivalent to Rv0890c,len: 882 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 882 aa overlap). Probable transcriptional regulatory protein, LuxR family, highly similar (but shorter 238 aa in N-terminus) to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar (generally in part) to others e.g. T50568 probable multi-domain regulatory protein from Streptomyces coelicolor (1334 aa); P10957|NARL_ECOLI nitrate/nitrite response regulator protein from Escherichia coli (216 aa),FASTA scores: opt: 193, E(): 6e-06, (37.4% identity in 99 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. MTCY02B10_22, MTV008_44,MTV036_21, and MTCY31_24. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, and probable helix-turn helix motif from aa 836 to 857 (Score 1559, +4.50 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. X2BGB7,P59969 No regulatory proteins Rv0890c NC_002945.3 Mycobrowser_v2 CDS 1002906 1003169 . - 0 Mb0922c CONSERVED HYPOTHETICAL PROTEIN Mb0922c, -, len: 87 aa. Equivalent to Rv0898c, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 87 aa overlap). Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap). X2BGG5 No conserved hypotheticals Rv0898c NC_002945.3 Mycobrowser_v2 CDS 4152175 4152357 . - 0 Mb3797c PROBABLE REMNANT OF A TRANSPOSASE Mb3797c, -, len: 60 aa. Equivalent to Rv3770A, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 204, E(): 1e-07, (80.5% identity in 41 aa overlap). Continuation of Rv3770B. Q7TVQ3 No insertion seqs and phages Rv3770A NC_002945.3 Mycobrowser_v2 CDS 367197 370640 . - 0 Mb0312c PPE5 ppe family protein ppe5 Mb0312c, PPE5, len: 1147 aa. Equivalent to 3' end of Rv0304c, len: 2204 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1147 aa overlap). Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Z95324|MTY13E10_16 from M. tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from M. tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0,(42.3% identity in 522 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a shorter CDS (Mb0312c) equivalent to the 3' end of Rv0304c/PPE5. Q7U2B3 No NC_002945.3 Mycobrowser_v2 CDS 3077981 3078307 . - 0 Mb2839c PROBABLE TRANSPOSASE Mb2839c, -, len: 108 aa. Equivalent to Rv2815c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Probable transposase,identical from aa 51 with P19772|YIA2_MYCTU PUTATIVE TRANSPOSASE (INSERTION ELEMENT IS986) from Mycobacterium tuberculosis (59 aa), FASTA scores: opt: 365, E(): 1.1e-19, (96.6% identity in 59 aa overlap); and other transposases. X2BLL3,P59801 No insertion seqs and phages Rv2815c NC_002945.3 Mycobrowser_v2 CDS 1172835 1173281 . + 0 Mb1078 PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN Mb1078, -, len: 148 aa. Equivalent to Rv1049, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 148 aa overlap). Probable transcriptional repressor protein, similar to many e.g. P74870 NEGATIVE REGULATOR OF EMR LOCUS EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn -helix motif at aa 58-79 (Score 1495, +4.28 SD). Q7U0S7 No regulatory proteins Rv1049 NC_002945.3 Mycobrowser_v2 CDS 308619 309074 . - 0 Mb0264c CONSERVED HYPOTHETICAL PROTEIN Mb0264c, -, len: 151 aa. Equivalent to Rv0258c,len: 151 aa (alternative start possible), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 151 aa overlap). Conserved hypothetical protein,showing some similarity to Rv1685c|MTCI125_6 from Mycobacterium tuberculosis (207 aa), FASTA scores: E(): 9.3e-07, (32.1% identity in 140 aa overlap). Also some similarity with AL049819|SCE7_13|T36295 probable transcription regulator from Streptomyces coelicolor (204 aa), FASTA scores: opt: 158, E(): 0.00052, (27.0% identity in 111 aa overlap). Q7U2F7 No conserved hypotheticals Rv0258c NC_002945.3 Mycobrowser_v2 CDS 1058113 1058430 . - 0 Mb0973c chorismate mutase Mb0973c, -, len: 105 aa. Equivalent to Rv0948c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 105 aa overlap). Conserved hypothetical protein, equivalent to NP_301237.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (105 aa). Also similar (except in N-terminus) to SCD63.16c|CAB82023.1|AL161755 hypothetical protein from Streptomyces coelicolor (110 aa); and to N-terminus of two chorismate mutase/prephenate dehydratase. X2BGA2,P64768 No intermediary metabolism and respiration Rv0948c NC_002945.3 Mycobrowser_v2 CDS 3831221 3831889 . + 0 Mb3495 CONSERVED HYPOTHETICAL PROTEIN Mb3495, -, len: 222 aa. Equivalent to Rv3466, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(98.2% identity in 222 aa overlap). Conserved hypothetical ORF in REP13E12 repeat, but extending 5' of repeat. Has segment of identity to other REP13E12 ORF's e.g. MTCY336.16, MTCI65.15c, MTCY09F9.19, cMTCY251.14c. Q7TWG5 No insertion seqs and phages Rv3466 NC_002945.3 Mycobrowser_v2 CDS 963300 963581 . + 0 Mb0886 CONSERVED HYPOTHETICAL PROTEIN Mb0886, -, len: 93 aa. Equivalent to Rv0863, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, highly similar to NP_302418.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (74 aa). Also weakly similar in part to U82598|ECU82598_135 HYPOTHETICAL PROTEIN from Escherichia coli, FASTA scores: (32.4% identity in 71 aa overlap); and M74011|YEPYSCOP_8 HYPOTHETICAL PROTEIN from Yersinia enterocolitica (165 aa), FASTA scores: (38.6 identity in 57 aa overlap). Q7U130 No conserved hypotheticals Rv0863 NC_002945.3 Mycobrowser_v2 CDS 1570419 1570820 . - 0 Mb1432c vapc10 possible toxin vapc10 Mb1432c, -, len: 133 aa. Equivalent to Rv1397c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 133 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis protein MTCY159.08C|Rv2548 (125 aa), FASTA scores: E(): 2.3e-14,(42.4% identity in 125 aa overlap). Q7U048 No virulence, detoxification, adaptation Rv1397c NC_002945.3 Mycobrowser_v2 CDS 1570817 1571074 . - 0 Mb1433c vapb10 possible antitoxin vapb10 Mb1433c, -, len: 85 aa. Equivalent to Rv1398c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 85 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis proteins Rv2547|MTCY159.09C (85 aa), FASTA scores: E(): 0.0035,(37.1% identity in 62 aa overlap); Rv0581, Rv2871, Rv1241,etc. X2BHT5,P64836 No virulence, detoxification, adaptation Rv1398c NC_002945.3 Mycobrowser_v2 CDS 172401 173333 . + 0 Mb0151 possible s-adenosylmethionine-dependent methyltransferase Mb0151, -, len: 310 aa. Equivalent to Rv0146, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Conserved hypothetical protein, highly similar to others e.g. AC30975.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (304 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc. X2BE60,Q7U2R2 No lipid metabolism Rv0146 NC_002945.3 Mycobrowser_v2 CDS 1613289 1613714 . - 0 Mb1474c unknown protein Mb1474c, -, len: 141 aa. Equivalent to Rv1439c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 141 aa overlap). Hypothetical unknown protein. Q7U028 No conserved hypotheticals Rv1439c NC_002945.3 Mycobrowser_v2 CDS 1265977 1266318 . + 0 Mb1168 POSSIBLE ENOYL-COA HYDRATASE Mb1168, -, len: 113 aa. Equivalent to Rv1136, len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 113 aa overlap). Probable enoyl-CoA hydratase (possible gene fragment) (EC 5.-.-.-). Some similarity to N-terminus of carnitine racemases and enoyl-CoA hydratases (but much shorter) e.g. I41014 carnitine racemase from Escherichia coli (297 aa), FASTA scores: opt: 258, E(): 2.5e-11, (44.5% identity in 110 aa overlap); and Rv0222 putative enoyl-CoA hydratase from M. tuberculosis (262 aa). Q7U0K3 No lipid metabolism Rv1136 NC_002945.3 Mycobrowser_v2 CDS 464428 467685 . + 0 Mb0393 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR/UHPA-FAMILY) Mb0393, -, len: 1085 aa. Equivalent to Rv0386, len: 1085 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1085 aa overlap). Probable regulatory protein, LuxR/uhpA family, highly similar to CAC30706.1|AL583923 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar in part to other regulatory proteins e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); N-terminus of CAB92369.1|AL356612 putative AfsR-like regulatory protein from Streptomyces coelicolor (1114 aa); N-terminus of NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional regulator from Mesorhizobium loti (952 aa); AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores: opt: 224,E() : 1.1e-06, (26.1% identity in 867 aa overlap); etc. Also similar to many putative Mycobacterium tuberculosis regulatory proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA scores: opt: 3756, E(): 0, (56.7% identity in 1089 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature and probable helix-turn-helix motif at aa 1042-1063 (Score 1025, +2.68 S D). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U243 No regulatory proteins Rv0386 NC_002945.3 Mycobrowser_v2 CDS 1887793 1888695 . + 0 Mb1705 probable integral membrane protein Mb1705, -, len: 300 aa. Equivalent to Rv1678, len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 300 aa overlap). Probable integral membrane protein. Q7TZT2 No cell wall and cell processes Rv1678 NC_002945.3 Mycobrowser_v2 CDS 2939059 2939550 . - 0 Mb2683c CONSERVED HYPOTHETICAL PROTEIN Mb2683c, -, len: 163 aa. Equivalent to Rv2665A,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein; N-terminus highly similar to N-terminus of Rv1046c from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 313, E(): 2.9e-11, (44.7% identity in 159 aa overlap). Alternative to Rv2665. Q7TY58 No Rv2665A NC_002945.3 Mycobrowser_v2 CDS 2893191 2893595 . + 0 Mb2627 vapc40 possible toxin vapc40. contains pin domain. Mb2627, -, len: 134 aa. Equivalent to Rv2596, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Conserved hypothetical protein, only similar to O07780|Rv0598c|MTCY19H5.24 HYPOTHETICAL 14.8 KDA PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA scores: opt: 254, E(): 8.8e-11, (41.55% identity in 130 aa overlap). Q7TY97 No virulence, detoxification, adaptation Rv2596 NC_002945.3 Mycobrowser_v2 CDS 2292044 2294668 . - 0 Mb2077c ppm1 Polyprenol-monophosphomannose synthase Ppm1 Mb2077c, ppm1, len: 874 aa. Equivalent to Rv2051c,len: 874 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 874 aa overlap). ppm1,Polyprenol-monophosphomannose synthase. Transfers mannose from GDP-Mannose to all endogenous polyprenol-phosphates in Mycobacterium tuberculosis, proven experimentally (A. Baulard, Institut Pasteur de Lille: see citation below). Very similar to polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). Two-domain protein similar to products of two adjacent ORFs in Mycobacterium leprae MLCB2052.01 (644 aa), probable membrane protein and MLCB2052.02 (277 aa). First domain (aa 1 - 590) corresponds to membrane protein with similarity to P23930|LNT_ECOLI apolipoprotein n-acyltransferase (512 aa) while second domain (aa 591 -874) is similar to Schizosaccharomyces pombe dolichol monophosphate mannose synthase (236 aa) and to Mycobacterium tuberculosis Rv0539. FASTA scores: Z 98604|MLCB2052_1 (644 aa) opt: 2725 E(): 0 ; 67.7% identity in 601 aa overlap; and Z98604|MLCB2052_2 (277 aa) opt: 1449 E(): 0; 78.9% identity in 275 aa overlap; and gp|AF0078|AF007873_1 Schizosaccharomyces pombe dolichocholmonophosphate mannose synthase (236 aa) opt: 456 E(): 7.8e-19; 34.5% identity in 223 aa overlap and sp|P23930|LNT_ECOLI APOLIPOPROTEIN N-ACYLTRANSFERASE (512 aa) opt: 330 E(): 1.9e-11; 26.9% identity in 539 aa overlap; and polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). CAC15462.1|AJ294477 putative polyprenol-phosphate-mannose synthase 2 (Ppm2): (55% identity in 533 aa overlap). Q7VES1 No NC_002945.3 Mycobrowser_v2 CDS 2893812 2894432 . + 0 Mb2628 PROBABLE MEMBRANE PROTEIN Mb2628, -, len: 206 aa. Equivalent to Rv2597, len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Probable membrane protein. X2BKW7,P65030 No cell wall and cell processes Rv2597 NC_002945.3 Mycobrowser_v2 CDS 567795 568241 . + 0 Mb0487 POSSIBLE CONSERVED SECRETED PROTEIN Mb0487, -, len: 148 aa. Equivalent to Rv0477, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Possible conserved secreted protein, equivalent to CAC31969.1|AL583925 hypothetical protein from Mycobacterium leprae (123 aa). Also similar to G83406|PA1914 conserved hypothetical protein from Pseudomonas aeruginosa (408 aa). Contains possible N-terminal signal sequence. X2BF58 No cell wall and cell processes Rv0477 NC_002945.3 Mycobrowser_v2 CDS 171405 172358 . + 0 Mb0150 possible s-adenosylmethionine-dependent methyltransferase Mb0150, -, len: 317 aa. Equivalent to Rv0145, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Conserved hypothetical protein, highly similar to many e.g. CAC32172.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (310 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc. X2BE73,Q7U2R3 No lipid metabolism Rv0145 NC_002945.3 Mycobrowser_v2 CDS 1953314 1953562 . + 0 Mb1770 vapc34 possible toxin vapc34. contains pin domain. Mb1770, -, len: 82 aa. Equivalent to Rv1741, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 82 aa overlap). Conserved hypothetical protein, very similar in N-terminus to other M. tuberculosis hypothetical proteins e.g. P96914|Rv0624|MTCY20H10.05 (131 aa), (80.4% identity in 56 aa overlap); P71999|Rv1741 (82 aa) and O07769|Rv0609 (133 aa). Q7TZN5 No virulence, detoxification, adaptation Rv1741 NC_002945.3 Mycobrowser_v2 CDS 570951 571475 . - 0 Mb0491c HYPOTHETICAL PROTEIN Mb0491c, -, len: 174 aa. Equivalent to Rv0481c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Hypothetical unknown protein. X2BF55 No conserved hypotheticals Rv0481c NC_002945.3 Mycobrowser_v2 CDS 584526 584855 . - 0 Mb0503c HYPOTHETICAL PROTEIN Mb0503c, -, len: 109 aa. Equivalent to Rv0492A,len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein. GC plot suggests CDS. Q7U1W5 No conserved hypotheticals Rv0492A NC_002945.3 Mycobrowser_v2 CDS 65542 66684 . + 0 Mb0063 celA1 POSSIBLE CELLULASE CELA1 (ENDOGLUCANASE) (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL CELLULASE) Mb0063, celA1, len: 380 aa. Equivalent to Rv0062,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Possible celA1,cellulase (EC 3.2.1.4), similar to many e.g. AB65568.1|AL136058 putative secreted endoglucanase (cellulase) from Streptomyces coelicolor (332 aa); P07984|GUNA_CELFI ENDOGLUCANASE A PRECURSOR from Cellulomonas fimi (449 aa); GUN1_STRHA|P33682 endoglucanase 1 precursor (cellulase) from STREPTOMYCES HALSTEDII (321 aa), FASTA scores: opt: 702, E(): 1. 2e-27,(38.9% identity in 319 aa overlap); etc. SEEMS TO BELONG TO CELLULASE FAMILY B (FAMILY 6 OF GLYCOSYL HYDROLASES). Note that previously known as celA. Q7U2Y0 No NC_002945.3 Mycobrowser_v2 CDS 193816 194301 . + 0 Mb0169 TB18.5 conserved protein tb18.5 Mb0169, TB18.5, len: 161 aa. Equivalent to Rv0164,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). TB18.5, conserved hypothetical protein, equivalent to CAB08818.1|Z95398 HYPOTHETICAL PROTEIN from Mycobacterium leprae (156 aa) FASTA scores: opt: 762, E(): 0, (76.3% identity in 152 aa overlap). Some similarity to Rv2185c, Rv0854, Rv0857 from Mycobacterium tuberculosis. Alternative start codon has been suggested. 3' part corrected since first submission (-24 aa). Q7U2P4 No NC_002945.3 Mycobrowser_v2 CDS 1265685 1265927 . + 0 Mb1167 POSSIBLE ACETYL-COA ACETYLTRANSFERASE (ACETOACETYL-COA THIOLASE) Mb1167, -, len: 80 aa. Equivalent to Rv1135A, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 80 aa overlap). Possible acetyl-CoA acetyltransferase (EC 2.3.1.9) (possible gene fragment),highly similar to other acetyl-CoA acetyltransferases e.g. C-terminal part of Rv3556c|Z92774|MTCY6G11_2|MTCY06G11.03|fadA6 ACETYL-COA ACETYLTRANSFERASE from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 219, E(): 5.7e-09, (63.6% identity in 55 aa overlap). Q7U0K4 No lipid metabolism Rv1135A NC_002945.3 Mycobrowser_v2 CDS 3280 4437 . + 0 Mb0003 recF DNA REPLICATION AND REPAIR PROTEIN RECF (SINGLE-STRAND DNA BINDING PROTEIN) Mb0003, recF, len: 385 aa. Equivalent to Rv0003,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 385 aa overlap). recF, DNA replication and repair protein (see citations below), equivalent to others Mycobacterial DNA replication and repair proteins e.g. NP_301131.1|NC_002677 from Mycobacterium leprae (385 aa); Q9L7L5|RECF_MYCPA from Mycobacterium avium subsp. paratuberculosis (385 aa); P50916|RECF_MYCSM from Mycobacterium smegmatis (384 aa); etc. Also highly similar to others e.g. P36176|RECF_STRCO DNA REPLICATION AND REPAIR PROTEIN from Streptomyces coelicolor (373 aa); NP_440892.1|NC_000911 from Synechocystis sp. strain PCC 6803 (384 aa); NP_469352.1|NC_003212 from Listeria innocua (370 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00617 RecF protein signature 1, and PS00618 RecF protein signature 2. BELONGS TO THE RECF FAMILY. X2BDR1,Q7U314 No information pathways Rv0003 NC_002945.3 Mycobrowser_v2 CDS 222063 222353 . + 0 Mb0196 conserved protein Mb0196, -, len: 96 aa. Equivalent to Rv0190, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Conserved hypothetical protein, highly similar to several hypothetical proteins e.g. SYCSLRA_35|Q55554|SLL0176 hypothetical 18.9 KD protein from Synechocystis (167 aa), FASTA scores: opt: 237, E(): 5.8e-16, (39.4% identity in 94 aa overlap). Also highly similar to Z95398|MLCL622_7|O06070 from Mycobacterium leprae (135 aa), FASTA score: (82.6% identity in 92 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0967,Rv0030, Rv1766 (42.5% identity in 80 aa overlap). Q7U2M0 No conserved hypotheticals Rv0190 NC_002945.3 Mycobrowser_v2 CDS 331033 331461 . - 0 Mb0283c vapc25 possible toxin vapc25. contains pin domain. Mb0283c, -, len: 142 aa. Equivalent to Rv0277c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, highly similar to Rv0749|H70824|2911023|CAA17516.1|AL021958 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (142 aa); and similar to several other hypothetical Mycobacterium tuberculosis proteins: Rv0277c, Rv2530c,etc. Q7U2D9 No virulence, detoxification, adaptation Rv0277c NC_002945.3 Mycobrowser_v2 CDS 84031 85203 . + 0 Mb0077 PROBABLE AMINOTRANSFERASE Mb0077, -, len: 390 aa. Equivalent to Rv0075, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Probable aminotransferase (EC 2.6.1.-), similar to many CLASS-II PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES (MALY/PATB SUBFAMILY) e.g. NP_302217.1|NC_002677 aminotransferase from Mycobacterium leprae (402 aa); PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa), FASTA scores: opt: 684, E(): 5.4e-33, (31.3% identity in 384 aa overlap); etc. Also similar to several cystathionine beta-lyase (beta C-S lyase) e.g. AAK69425.1|AF276227_1|AF276227 from Corynebacterium glutamicum (368 aa); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv2294, Rv0858c,etc. Q7U2W8 No intermediary metabolism and respiration Rv0075 NC_002945.3 Mycobrowser_v2 CDS 1 1524 . + 0 Mb0001 dnaA CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA Mb0001, dnaA, len: 507 aa. Equivalent to Rv0001,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 507 aa overlap). dnaA, chromosomal replication initiator protein (see citations below),equivalent to other Mycobacterial CHROMOSOMAL REPLICATION INITIATOR PROTEINS e.g. P46388|DNAA_MYCLE from Mycobacterium leprae (502 aa); Q9L7L7|DNAA_MYCPA from Mycobacterium paratuberculosis (509 aa); P49990|DNAA_MYCAV from Mycobacterium avium (508 aa); P49992|DNAA_MYCSM from Mycobacterium smegmatis (504 aa); etc. Also highly similar to others except in N-terminus e.g. Q9ZH75|DNAA_STRCH CHROMOSOMAL REPLICATION INITIATOR PROTEIN from Streptomyces chrysomallus (624 aa); Q9ZH76|DNAA_STRRE from Streptomyces reticuli (643 aa); DNAA_ECOLI|P03004|B3702 chromosomal replication initiator protein from Escherichia coli strain K12 (467 aa), FASTA scores: opt: 986, E(): 0,(43.2% identity in 389 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS01008 DnaA protein signature. BELONGS TO THE DNAA FAMILY. Note that the first base of this gene has been taken as base 1 of the Mycobacterium bovis genomic sequence. X2BDR0,P49991 No information pathways Rv0001 NC_002945.3 Mycobrowser_v2 CDS 2052 3260 . + 0 Mb0002 dnaN DNA POLYMERASE III (BETA CHAIN) DNAN (DNA NUCLEOTIDYLTRANSFERASE) Mb0002, dnaN, len: 402 aa. Equivalent to Rv0002,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 402 aa overlap). dnaN, DNA polymerase III (beta chain) (EC 2.7.7.7) (see citations below),equivalent to other Mycobacterial DNA POLYMERASES III BETA CHAIN e.g. NP_301130.1|NC_002677 from Mycobacterium leprae (399 aa); Q9L7L6|DP3B_MYCPA from Mycobacterium avium subsp. paratuberculosis (399 aa); P52851|DP3B_MYCSM from Mycobacterium smegmatis (397 aa); etc. Also highly similar to others e.g. P27903|DP3B_STRCO DNA POLYMERASE III BETA CHAIN from Streptomyces coelicolor (376 aa), FASTA scores: opt: 1189, E(): 0, (52.8% identity in 337 aa overlap); P21174|DP3B_MICLU from Micrococcus luteus (310 aa); P52023|DP3B_SYNP7 from Synechococcus sp. strain PCC 7942 (375 aa); etc. Overlaps and extends CDS in neighbouring cosmid MTCY10H4.01. X2BDQ9,O33914 No information pathways Rv0002 NC_002945.3 Mycobrowser_v2 CDS 82783 84018 . + 0 Mb0076 conserved protein Mb0076, -, len: 411 aa. Equivalent to Rv0074, len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Conserved hypothetical protein, similar to Rv2915c|MTCY338.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and showing some simlarity to various enzymes or hypothetical proteins from other organisms, eg NP_243801.1|NC_002570 aryldialkylphosphatase from Bacillus halodurans (394 aa); NP_421471.1|NC_002696 putativ Xaa-Pro dipeptidase from Caulobacter crescentus (429 aa); NP_343436.1|NC_002754 Prolidase (Xaa-Pro dipeptidase) (pepQ-like2) from Sulfolobus solfataricus (408 aa); Q50432|M91040 ORGANO PHOSPHATE ACID ANHYDRASE OPAB from MYCOBACTERIUM SP. (409 aa), FASTA scores: opt: 166, E(): 3.9e-11, (31.2% identity in 430 aa overlap); etc. Q7U2W9 No conserved hypotheticals Rv0074 NC_002945.3 Mycobrowser_v2 CDS 4434 4997 . + 0 Mb0004 CONSERVED HYPOTHETICAL PROTEIN Mb0004, -, len: 187 aa. Equivalent to Rv0004, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Conserved hypothetical protein (see citation below), highly similar, but longer 21 aa in N-terminus, to AAF33696.1|AF222789 unknown protein from Mycobacterium avium subsp. paratuberculosis (166 aa); and highly similar to NP_301132.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (189 aa); S70990 hypothetical protein from Mycobacterium smegmatis (194 aa). Also similar to in C-terminus to C-terminal part of P35925|YREG_STRCO HYPOTHETICAL 19.8 KDA PROTEIN (IN RECF-GYRB INTERGENIC REGION) from Streptomyces coelicolor (190 aa), FASTA scores: opt: 404, E(): 3.9e-18,(40.7% identity in 189 aa overlap). X2BDR3 No conserved hypotheticals Rv0004 NC_002945.3 Mycobrowser_v2 CDS 85671 86501 . - 0 Mb0079c PROBABLE OXIDOREDUCTASE Mb0079c, -, len: 276 aa. Equivalent to Rv0077c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Possible oxidoreductase (EC 1.-.-.-), weakly similar to others e.g. CAC44600.1|AL596162 putative oxidoreductase from Streptomyces coelicolor (275 aa); P33912|BPA1_STRAU NON-HAEM BROMOPEROXIDASE BPO-A1 (BROMIDE PEROXIDASE) (EC 1.11.1.-) from Streptomyces aureofaciens (275 aa); BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 230, E(): 1.5e-07, (26.1% identity in 249 aa overlap); etc. Also similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium tuberculosis. And shows some similarity in part with AAL17935.1|AY054120 putative epoxide hydrolase from Mycobacterium smegmatis (203 aa). Q7U2W6 No intermediary metabolism and respiration Rv0077c NC_002945.3 Mycobrowser_v2 CDS 5123 7267 . + 0 Mb0005 gyrB DNA GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE) Mb0005, gyrB, len: 714 aa. Equivalent to Rv0005,len: 714 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 714 aa overlap). gyrB, DNA gyrase subunit B (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT B e.g. T10005 from Mycobacterium leprae (697 aa); Q9L7L3|GYRB_MYCPA from Mycobacterium avium subsp. paratuberculosis (677 aa) (has its N-terminus shorter); P48355|GYRB_MYCSM from Mycobacterium smegmatis (675 aa); etc. Also highly similar to others e.g. T10969 from Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH from Streptomyces spheroides (684 aa); etc. Contains PS00177 DNA topoisomerase II signature. BELONGS TO THE TYPE II TOPOISOMERASE FAMILY. Q7U312 No information pathways Rv0005 NC_002945.3 Mycobrowser_v2 tRNA 4153159 4153231 . - 0 argU argU tRNA-Arg argU, len: 73 nt. Equivalent to argU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon acg. No NC_002945.3 Mycobrowser_v2 CDS 7302 9818 . + 0 Mb0006 gyrA DNA GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE) Mb0006, gyrA, len: 838 aa. Equivalent to Rv0006,len: 838 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 838 aa overlap). gyrA, DNA gyrase subunit A (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from Mycobacterium leprae (1273 aa); P48354|GYRA_MYCSM from Mycobacterium smegmatis (842 aa); etc. Also highly similar to others e.g. P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from Streptomyces coelicolor (864 aa); NP_346654.1|NC_003030 from Clostridium acetobutylicum (830 aa); NP_387888.1|NC_000964 from Bacillus subtilis (821 aa); etc. Contains PS00018 EF-hand calcium-binding domain. Q7U311 No information pathways Rv0006 NC_002945.3 Mycobrowser_v2 CDS 9914 10828 . + 0 Mb0007 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0007, -, len: 304 aa. Equivalent to Rv0007, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Possible conserved membrane protein, highly similar to Z70722|MLCB1770_7 from Mycobacterium leprae (303 aa), FASTA scores: opt: 812,E(): 1.6e-25, (54.2% identity in 319 aa overlap). C-terminal part highly similar to C-terminus of CAB92992.1|AL357152 putative integral membrane protein from Streptomyces coelicolor (185 aa); and N-terminal part highly similar to C-terminus of NP_302684.1|NC_002677 hypothetical protein from Mycobacterium leprae (123 aa). Q7U310 No cell wall and cell processes Rv0007 NC_002945.3 Mycobrowser_v2 tRNA 10887 10960 . + 0 ileT ileT tRNA-Ile ileT, len: 74 nt. Equivalent to ileT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Ile, anticodon gat. No NC_002945.3 Mycobrowser_v2 CDS 17466 18761 . - 0 Mb0015c pknA TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE A PKNA (PROTEIN KINASE A) (STPK A) Mb0015c, pknA, len: 431 aa. Equivalent to Rv0015c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). pknA, transmembrane serine/threonine-protein kinase (EC 2.7.1.-),magnesium/manganese dependent (see citations below),equivalent to MLCB1770_10|NP_301143.1|NC_002677 putative serine/threonine protein kinase from Mycobacterium leprae (437 aa), FASTA scores: opt: 1883, E(): 0, (72.1% identity in 434 aa overlap). And also highly similar to other kinases from Mycobacterium leprae e.g. MLCB1770_10 from Mycobacterium leprae (437 aa). Also similar to PKNA_MYCLE protein kinase (253 aa), FASTA scores: opt: 1525, E(): 0,(95.0% identity in 242 aa overlap); etc. Also highly similar in part to others e.g. N-terminus of NP_243370.1|NC_002570 from Bacillus halodurans (664 aa); N-terminus of T36717 from Streptomyces coelicolor (673 aa); etc. Also similar to others from Mycobacterium tuberculosis: MTCY10H4_15, MTV021_9, MTCY28_5,MTCY4C12_28, MTCY50_16, MTCY8D9_8, MTCY49_28, MTCY4C12_30,MTCY28_9, etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. It has been shown that sodium orthovanadate inhibits the activity of the enzyme in vitro. X2BDS0,P65727 No NC_002945.3 Mycobrowser_v2 CDS 12468 13016 . + 0 Mb0009 ppiA PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A) Mb0009, ppiA, len: 182 aa. Equivalent to Rv0009,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable ppiA (alternate gene name: cfp22), iron-regulated peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8),equivalent to NP_301138.1|NC_002677 putative peptidyl-prolyl cis-trans isomerase from Mycobacterium leprae (182 aa), FASTA score: (90.1% identity in 182 aa overlap). Also highly similar to others e.g. T36725 from Streptomyces coelicolor (177 aa); T43805 from Halobacterium salinarum (180 aa); NP_219383.1|NC_000919 from Treponema pallidum (215 aa); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY. Alternative start codon has been suggested. X2BDS2,P65763 No information pathways Rv0009 NC_002945.3 Mycobrowser_v2 CDS 13222 13557 . - 0 Mb0010c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0010c, -, len: 111 aa. Equivalent to Rv0010c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Probable conserved membrane protein, equivalent to NP_301139.1|NC_002677 putative membrane protein from Mycobacterium leprae (137 aa); and similar to Rv1417|P71686|YE17_MYCTU HYPOTHETICAL 16.4 KD PROTEIN from Mycobacterium tuberculosis (154 aa),FASTA scores: opt: 121, E(): 0.097, (29.6% identity in 81 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa). Q7U309 No cell wall and cell processes Rv0010c NC_002945.3 Mycobrowser_v2 CDS 13713 13994 . - 0 Mb0011c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0011c, -, len: 93 aa. Equivalent to Rv0011c, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable conserved transmembrane protein, equivalent to NP_301140.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (93 aa); and similar to AL079308|SCH69_24 hypothetical protein from Streptomyces coelicolor (84 aa), FASTA scores: opt: 135, E(): 0.0068, (32.6% identity in 92 aa overlap). X2BDR8,P67377 No cell wall and cell processes Rv0011c NC_002945.3 Mycobrowser_v2 CDS 58182 58472 . + 0 Mb0054 rpsF 30s ribosomal protein s6 rpsf Mb0054, rpsF, len: 96 aa. Equivalent to Rv0053,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Probable 30S ribosomal protein S6, equivalent to RS6_MYCLE|P46389 30s ribosomal protein s6 from Mycobacterium leprae (96 aa), FASTA scores: opt: 570, E(): 1.1e-36, (91.7% identity in 96 aa overlap).Also highly similar to many e.g. Q9X8U2|RS6_STRCO 30S RIBOSOMAL PROTEIN S6 from Streptomyces coelicolor (96 aa); etc. Note that the putative product of this CDS corresponds to spot 6_26 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). Contains PS01048 Ribosomal protein S6 signature. BELONGS TO THE S6P FAMILY OF RIBOSOMAL PROTEINS. X2BDX0,P66592 No information pathways Rv0053 NC_002945.3 Mycobrowser_v2 CDS 59399 59857 . + 0 Mb0057 rplI 50s ribosomal protein l9 rpli Mb0057, rplI, len: 152 aa. Equivalent to Rv0056,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Probable rplI, 50S ribosomal protein L9, equivalent to RL9_MYCLE|P46385 50s ribosomal protein l9 from Mycobacterium leprae (152 aa),FASTA scores: opt: 847, E(): 0, (88.7% identity in 150 aa overlap). Also highly similar to others e.g. Q9X8U5|RL9_STRCO 50S RIBOSOMAL PROTEIN L9 from Streptomyces coelicolor (148 aa); etc. Contains PS00651 Ribosomal protein L9 signature. BELONGS TO THE L9P FAMILY OF RIBOSOMAL PROTEINS. X2BDW5,P66316 No information pathways Rv0056 NC_002945.3 Mycobrowser_v2 CDS 14088 14876 . + 0 Mb0012 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0012, -, len: 262 aa. Equivalent to Rv0012, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv (99.2% identity in 262 aa overlap). Probable conserved membrane protein, similar to AL079308|SCH69_23|T36722 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 506, E(): 1.9e-25, (39.8% identity in 236 aa overlap). Some similarity to BLU0|1958_35A2 DIVIB (fragment) (188 aa), FASTA scores: opt: 204, E(): 8.9e-07, (35.6% identity in 90 aa overlap); and G1129091|DDS cell division and sporulation protein from Bacillus subtilis (231 aa), FASTA scores: opt: 180, E(): 3.8e-05, (30.7% identity in 101 aa overlap). Also similar to Rv1823|MTCY1A11_20 from Mycobacterium tuberculosis FASTA score: (30.1% identity in 246 aa overlap); and MTCY1A11_18 FASTA score: (25.5% identity in 235 aa overlap). Contains probable N-terminal signal sequence. Q7U308 No cell wall and cell processes Rv0012 NC_002945.3 Mycobrowser_v2 CDS 14913 15611 . + 0 Mb0013 trpG POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE) Mb0013, trpG, len: 232 aa. Equivalent to Rv0013,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 232 aa overlap). Possible trpG,anthranilate synthase component II (glutamine amidotransferase) (EC 4.1.3.27), equivalent to NP_301141.1|NC_002677 putative p-aminobenzoate synthase glutamine amidotransferase from Mycobacterium leprae (232 aa). Also highly similar to others e.g. P26922|TRPG_AZOBR Anthranilate synthase component II from Azospirillum brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40,(56.7% identity in 187 aa overlap); T36720 probable glutamine amidotransferase from Streptomyces coelicolor (212 aa); T44524 anthranilate synthase from Nitrosomonas europaea (199 aa); etc. Also similar to E235740 para-aminobenzoate synthase (232 aa), FASTA scores: opt: 1273, E(): 0, (79.7% identity in 232 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site; and PS00442 Glutamine amidotransferases class-I active site. SIMILARITY TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAINS. Note that previously known as pabA. Q7U307 No intermediary metabolism and respiration Rv0013 NC_002945.3 Mycobrowser_v2 CDS 27576 28346 . + 0 Mb0023 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0023, -, len: 256 aa. Equivalent to Rv0023, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible transcriptional regulator, equivalent to CAB96432.1|AJ251434 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (146 aa). N-terminus showing similarity with other transcriptional regulators e.g. AE0002|ECAE000240_9 from Escherichia coli strain K12 (178 aa), FASTA scores: opt: 149, E(): 0.0048,(33.3% identity in 84 aa overlap); etc. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). X2BDT3,P67705 No regulatory proteins Rv0023 NC_002945.3 Mycobrowser_v2 CDS 15589 17469 . - 0 Mb0014c pknB TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B PKNB (PROTEIN KINASE B) (STPK B) Mb0014c, pknB, len: 626 aa. Equivalent to Rv0014c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 626 aa overlap). pknB, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to MLCB1770_9|T10009 probable serine/threonine-specific protein kinase from Mycobacterium leprae (622 aa), FASTA scores: opt: 3600,E(): 0, (86.4% identity in 626 aa overlap). Also similar (highly similar in N-terminus) to others e.g. T36717 from Streptomyces coelicolor (673 aa); NP_389459.1|NC_000964 from Bacillus subtilis (648 aa); NP_465345.1|NC_003210 from Listeria monocytogenes (655 aa); E235741 protein kinase pknB (315 aa), FASTA scores: opt: 1839, E(): 0,(90.8 identity in 305 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature, and PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on serine/threonine residues. X2BDS6,P0A5S5 No NC_002945.3 Mycobrowser_v2 CDS 36851 37246 . + 0 Mb0035 CONSERVED HYPOTHETICAL PROTEIN Mb0035, -, len: 131 aa. Equivalent to Rv0034, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing weak similarity to AE001980|AE001980_7 hypothetical protein from Deinococcus radiodurans (120 aa), FASTA scores: opt: 141, E(): 0.0028,(29.3% identity in 123 aa overlap). X2BDT9 No conserved hypotheticals Rv0034 NC_002945.3 Mycobrowser_v2 CDS 383520 383906 . + 0 Mb0321 conserved protein Mb0321, -, len: 128 aa. Equivalent to Rv0313, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, equivalent only to CAC32049.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (130 aa). TBparse score is 0.877. Q7U2A4 No conserved hypotheticals Rv0313 NC_002945.3 Mycobrowser_v2 CDS 4344746 4344889 . - 0 Mb3955c rpmH 50S RIBOSOMAL PROTEIN L34 RPMH Mb3955c, rpmH, len: 47 aa. Equivalent to Rv3924c,len: 47 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 47 aa overlap). rpmH, 50s ribosomal protein l34 (see citations below), equivalent to many mycobacterial 50S RIBOSOMAL PROTEIN L34 e.g. P46386|RL34_MYCLE|RPMH|ML2713 from Mycobacterium leprae (47 aa), FASTA scores: opt: 287, E(): 8.5e-17, (91.5% identity in 47 aa overlap); and Q9L7L8|RL34_MYCPA|RPMH from M. paratuberculosis (47 aa), FASTA scores: opt: 281,E(): 2.6e-16, (89.35% identity in 47 aa overlap). Also highly similar to other ribosomal proteins e.g. P27901|RL34_STRCO|RPMH|STH24.02 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 234, E(): 1.4e-12,(79.05% identity in 43 aa overlap); and P05647|RL34_BACSU|RPMH from Bacillus subtilis (44 aa) FASTA scores: opt: 229, E(): 3.7e-12, (72.35% identity in 47 aa overlap); etc. Contains PS00784 Ribosomal protein L34 signature. BELONGS TO THE L34P FAMILY OF RIBOSOMAL PROTEINS. X2BPR0,P0A5W5 No NC_002945.3 Mycobrowser_v2 CDS 18758 20233 . - 0 Mb0016c pbpA PROBABLE PENICILLIN-BINDING PROTEIN PBPA Mb0016c, pbpA, len: 491 aa. Equivalent to Rv0016c,len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 491 aa overlap). Probable pbpA,penicillin-binding protein, equivalent to NP_301144.1|NC_002677 putative penicillin-binding protein from Mycobacterium leprae (492 aa); and highly similar to MLCB1770_1 penicillin binding protein from Mycobacterium leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4% identity in 472 aa overlap). Also similar to others e.g. T36716 from Streptomyces coelicolor (490 aa); AAF61246.1|AF241575|PbpA from Streptomyces griseus (485 aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum (482 aa); E235825|pbpA penicillin binding protein (325 aa), FASTA scores: opt: 1618, E(): 0, (78.3% identity in 323 aa overlap); etc. And also similar to MTCY270_5 and MTV003_8 from Mycobacterium tuberculosis. Q7U306 No NC_002945.3 Mycobrowser_v2 CDS 20230 21639 . - 0 Mb0017c rodA PROBABLE CELL DIVISION PROTEIN RODA Mb0017c, rodA, len: 469 aa. Equivalent to Rv0017c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein, equivalent to MLCB1770_12|T10012 probable cell division protein from Mycobacterium leprae (465 aa), FASTA scores: opt: 2475,E(): 0, (81.9% identity in 469 aa overlap). Also highly similar to others e.g. T36715|SCH69.16 from Streptomyces coelicolor (479 aa); NP_243432.1|NC_002570 from Bacillus halodurans (366 aa); NP_347145.1|NC_003030 from Clostridium acetobutylicum (400 aa); etc. Also similar to MTCY270_14 from Mycobacterium tuberculosis FASTA score: (32.2% identity in 369 aa overlap). BELONGS TO THE FTSW/RODA/SPOVE FAMILY. X2BDS4,P63761 No NC_002945.3 Mycobrowser_v2 CDS 21636 23180 . - 0 Mb0018c pstp phosphoserine/threonine phosphatase pstp Mb0018c, ppp, len: 514 aa. Equivalent to Rv0018c,len: 514 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 514 aa overlap). Possible ppp,serine/threonine phosphatase (EC 3.1.3.16), equivalent to MLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASE from Mycobacterium leprae (509 aa), FASTA scores: opt: 2517, E(): 0. Also highly similar to others e.g. T36714 probable protein phosphatase from Streptomyces coelicolor (515 aa); CAA10712.1|AJ132604 pppL protein from Lactococcus lactis (258 aa); NP_248765.1|NC_002516 probable phosphoprotein phosphatase from Pseudomonas aeruginosa (242 aa); etc. Also similar to BSUB0009_46 YLOO PROTEIN from Bacillus subtilis (254 aa), FASTA score: (34.0% identity in 250 aa overlap). Q7U305 No NC_002945.3 Mycobrowser_v2 CDS 96962 97636 . + 0 Mb0091 possible polyketide cyclase/dehydrase Mb0091, -, len: 224 aa. Equivalent to Rv0088, len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Hypothetical unknown protein. X2BDZ8 No lipid metabolism Rv0088 NC_002945.3 Mycobrowser_v2 CDS 23269 23736 . - 0 Mb0019c fhab conserved protein with fha domain, fhab Mb0019c, -, len: 155 aa. Equivalent to Rv0019c,len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 155 aa overlap). Conserved hypothetical protein, equivalent to MLCB1770_14|NP_301147.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (155 aa), FASTA scores: opt: 902, E(): 0, (91.0% identity in 155 aa overlap). Also highly similar to T36713|AL079308|SCH69_14 from Streptomyces coelicolor (172 aa), FASTA scores: opt: 389,E(): 6e-21, (46.2% identity in 171 aa overlap); and similar in C-terminus to others e.g. NP_342559.1|NC_002754 Conserved hypothetical protein from Sulfolobus solfataricus (209 aa); etc. C-terminus also highly similar to C-terminal part of AAF07901.1|AF173844_2|AF173844 putative signal transduction protein GarA from Mycobacterium smegmatis (158 aa). Also similar to Rv1827|MTCY 1A11.16c from Mycobacterium tuberculosis ( 162 aa), FASTA score: (41.2% identity in 85 aa overlap); MTMOAIS_3; MAU66560_1 and MLCB1788_15. Q7U304 No regulatory proteins Rv0019c NC_002945.3 Mycobrowser_v2 CDS 23860 25425 . - 0 Mb0020c fhaa conserved protein with fha domain, fhaa Mb0020c, TB39.8, len: 521 aa. Equivalent to Rv0020c, len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 527 aa overlap). TB39.8,conserved hypothetical protein, identified by proteomic study by the Statens Serum Institute, Denmark (spot TB39.8) (see citation below). Highly similar to NP_301148.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (488 aa); and Z70722|MLCB1770_15|T10015 hypothetical protein from Mycobacterium leprae (463 aa), FASTA scores: opt: 1213,E(): 2.2e-32, (72.3% identity in 506 aa overlap). Alternative start codon in position 24979 has been suggested. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 18 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (521 aa versus 527 aa). Q7U303 No regulatory proteins Rv0020c NC_002945.3 Mycobrowser_v2 CDS 59886 60407 . + 0 Mb0058 HYPOTHETICAL PROTEIN Mb0058, -, len: 173 aa. Equivalent to Rv0057, len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 173 aa overlap). Hypothetical unknown protein. X2BDW3 No conserved hypotheticals Rv0057 NC_002945.3 Mycobrowser_v2 CDS 25894 26862 . - 0 Mb0021c CONSERVED HYPOTHETICAL PROTEIN Mb0021c, -, len: 322 aa. Equivalent to Rv0021c,len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 322 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. NP_464341.1|NC_003210 protein similar to oxidoreductases from Listeria monocytogenes (309 aa); NP_357973.1|NC_003098 Enoyl-acyl carrier protein(ACP) reductase from Streptococcus pneumoniae (324 aa); 2NPD_NEUCR|G726338 2-nitropropane dioxygenase precursor from Neurospora crassa (378 aa), FASTA scores: opt: 383,E(): 1.1e-16, (32.2% identity in 348 aa overlap); etc. Also similar to AE001747_25 from Thermotoga maritima section 59 (314 aa), FASTA scores: opt: 442, E(): 1.5e-19,(30.5% identity in 325 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv3553 (355 aa), FASTA scores: E(): 6.8e-15, (35.3 identity in 235 aa overlap); and Rv1533 (375 aa), FASTA scores: E(): 4.7e-12,(34.4% identity in 262 aa overlap). Q7U302 No conserved hypotheticals Rv0021c NC_002945.3 Mycobrowser_v2 CDS 41988 42335 . - 0 Mb0040c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0040c, -, len: 115 aa. Equivalent to Rv0039c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 115 aa overlap). Possible conserved transmembrane protein, highly similar to NP_301154.1|NC_002677|Z70722|MLCB1770_18 hypothetical protein from Mycobacterium leprae (113 aa), FASTA scores: opt: 492, E(): 7.8e-27, (64.9% identity in 114 aa overlap). Q7U2Z2 No cell wall and cell processes Rv0039c NC_002945.3 Mycobrowser_v2 CDS 102850 103698 . - 0 Mb0096c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0096c, -, len: 282 aa. Equivalent to Rv0093c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Probable conserved membrane protein, equivalent only to CAC30943.1|AL583924 probable integral membrane protein from Mycobacterium leprae (237 aa). Q7U2V4 No cell wall and cell processes Rv0093c NC_002945.3 Mycobrowser_v2 CDS 27004 27423 . - 0 Mb0022c whiB5 probable transcriptional regulatory protein whib-like whib5 Mb0022c, whiB5, len: 139 aa. Equivalent to Rv0022c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable whiB5,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Shows some similarity to O88103|AJ239086|SCO239086_1|WHID|SC6G4.45c|WBLB WHID PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 125, E(): 0.055, (37.1% identity in 97 aa overlap); and slight similarity to G466960|WHIB WHIB PROTEIN (102 aa), FASTA scores: opt: 112, E(): 0.14, (34.3 identity in 67 aa overlap). Q7U301 No NC_002945.3 Mycobrowser_v2 CDS 33208 33537 . + 0 Mb0031 conserved hypothetical protein Mb0031, -, len: 109 aa. Equivalent to Rv0030, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein. X2BDT4 No conserved hypotheticals Rv0030 NC_002945.3 Mycobrowser_v2 CDS 28343 29176 . + 0 Mb0024 PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN [FIRST PART] Mb0024, -, len: 277 aa. Equivalent to 5' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 192 aa overlap). Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477,Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts, Mb0024 and Mb0025. Q7U300 No NC_002945.3 Mycobrowser_v2 CDS 28918 29187 . + 0 Mb0025 PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN [SECOND PART] Mb0025, -, len: 89 aa. Equivalent to 3' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 aa overlap). Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08,(37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts,Mb0024 and Mb0025. No NC_002945.3 Mycobrowser_v2 CDS 29225 29587 . + 0 Mb0026 CONSERVED HYPOTHETICAL PROTEIN Mb0026, -, len: 120 aa. Equivalent to Rv0025, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 120 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 aa), FASTA score: (37.6% identity in 101 aa overlap), and Rv0026 FASTA score: (35.4% identity in 113 aa overlap); etc. Q7U2Z9 No conserved hypotheticals Rv0025 NC_002945.3 Mycobrowser_v2 CDS 36591 36854 . + 0 Mb0034 acpA PROBABLE ACYL CARRIER PROTEIN ACPA (ACP) Mb0034, acpA, len: 87 aa. Equivalent to Rv0033,len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Probable acpA (alternate gene name: acpP), acyl carrier protein, similar to others e.g. ACP_BACSU|P80643 acyl carrier protein (acp) from Bacillus subtilis (77 aa), FASTA scores: opt: 149,E(): 0.00026, (41.4% identity in 70 aa overlap); NP_224500.1|NC_000922 Acyl Carrier Protein from Chlamydophila pneumoniae (79 aa); NP_228471.1|NC_000853 acyl carrier protein from Thermotoga maritima (81 aa); etc. Also similar to proteins of Mycobacterium tuberculosis Rv1344 and Rv2244 (31.5% identity in 73 aa overlap). Q7U2Z4 No lipid metabolism Rv0033 NC_002945.3 Mycobrowser_v2 CDS 59112 59366 . + 0 Mb0056 rpsR1 30s ribosomal protein s18-1 rpsr1 Mb0056, rpsR1, len: 84 aa. Equivalent to Rv0055,len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Probable rpsR1, 30S ribosomal protein S18-1, equivalent to NP_302711.1|NC_002677|O53125|RS18_MYCLE 30S RIBOSOMAL PROTEIN from Mycobacterium leprae (84 aa). Also highly similar to others e.g. Q9X8U4|R18A_STRCO 30S RIBOSOMAL PROTEIN S18-1 from Streptomyces coelicolor (78 aa); RS18_B|ACST|P10806 30s ribosomal protein s18 (bs21) (77 aa), FASTA scores: opt: 220, E(): 4e-10, (52.2% identity in 67 aa overlap); etc. Also similar to MTCY63A_5 from Mycobacterium tuberculosis. BELONGS TO THE S18P FAMILY OF RIBOSOMAL PROTEINS. Note that previously known as rpsR. X2BDW2,P69231 No information pathways Rv0055 NC_002945.3 Mycobrowser_v2 CDS 29702 31135 . + 0 Mb0027 CONSERVED HYPOTHETICAL PROTEIN Mb0027, -, len: 477 aa. Equivalent to 5' end of Rv0026, len: 448 aa, from Mycobacterium tuberculosis strain H37Rv, (94.4% identity in 449 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis: Rv0025 FASTA score: (35.4% identity in 113 aa overlap) and Rv0739 (268 aa), FASTA score: (32.4% identity in 142 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 4 bp insertion (*-atcg) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Q7U2Z8 No NC_002945.3 Mycobrowser_v2 CDS 31173 31490 . + 0 Mb0028 conserved hypothetical protein Mb0028, -, len: 105 aa. Equivalent to Rv0027, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Hypothetical unknown protein. X2BDT8 No conserved hypotheticals Rv0027 NC_002945.3 Mycobrowser_v2 CDS 31498 31803 . + 0 Mb0029 conserved hypothetical protein Mb0029, -, len: 101 aa. Equivalent to Rv0028, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Hypothetical unknown protein. X2BDU3 No conserved hypotheticals Rv0028 NC_002945.3 Mycobrowser_v2 CDS 32041 33138 . + 0 Mb0030 CONSERVED HYPOTHETICAL PROTEIN Mb0030, -, len: 365 aa. Equivalent to Rv0029, len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 365 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. C-terminal region of Rv2082|MTCY49_21|E247006 hypothetical 73.6 kDa protein (721 aa), FASTA scores: opt: 453, E(): 1.2e-22, (38.5% identity in 265 aa overlap); Rv3899c|MTY15F10_12 HYPOTHETICAL 40.8 KD PROTEIN (410 aa), FASTA score: (33.7% identity in 252 aa overlap); etc. Q7U2Z7 No conserved hypotheticals Rv0029 NC_002945.3 Mycobrowser_v2 CDS 34279 36594 . + 0 Mb0033 bioF2 POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE) Mb0033, bioF2, len: 771 aa. Equivalent to Rv0032,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 771 aa overlap). Probable bioF2,8-amino-7-oxononanoate synthase (EC 2.3.1.47), with its C-terminal similar to others e.g. BIOF_BACSU|P53556 8-amino-7-oxononanoate synthase from Bacillus subtilis (389 aa), FASTA scores: opt: 775, E(): 0, (37.9% identity in 346 aa overlap); P22806|BIOF_BACSH from Bacillus sphaericus (389 aa); etc. Also similar to BIOF1|Rv1569|MTCY336_35 from Mycobacterium tuberculosis (386 aa), AF041819_4 from Mycobacterium bovis, and BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Q7U2Z5 No NC_002945.3 Mycobrowser_v2 CDS 37243 38931 . + 0 Mb0036 fadD34 PROBABLE FATTY-ACID-COA LIGASE FADD34 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0036, fadD34, len: 562 aa. Equivalent to Rv0035,len: 562 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 562 aa overlap). Probable fadD34,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. MBU75685_1 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 408, E(): 8.2e-20; etc. Also similar to G1171128 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa),FASTA scores: opt: 445, E(): 1.3e-21, (28.1% identity in 573 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. MTCY02B10.09, FASTA score: (32.3% identity in 468 aa overlap), MTCY349_40,MTCY4D9_17, MTCY338_18, MTV045_3, MTCY409_4, MTCI237_30,MTCY24G1_8, MASC_MYCLE MASC PROTEIN, U00010_6, MTV005_21,MTCY19G5_7, MTCY9F9_39, etc. Q7U2Z3 No NC_002945.3 Mycobrowser_v2 CDS 39040 39813 . - 0 Mb0037c conserved protein Mb0037c, -, len: 257 aa. Equivalent to Rv0036c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Conserved hypothetical protein, highly similar to CAB95889.1|AL359988 conserved hypothetical protein from Streptomyces (276 aa). Also some similarity to Rv3099c|MTCY164_10 (283 aa), FASTA scores: E(): 3.3e-05,(25.9 % identity in 205 aa overlap). X2BDU5,P64676 No conserved hypotheticals Rv0036c NC_002945.3 Mycobrowser_v2 CDS 39861 41186 . - 0 Mb0038c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0038c, -, len: 441 aa. Equivalent to Rv0037c,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of macrolide, showing some similarity to Rv1258c|MTCY50_24 (419 aa), FASTA score: (25.2% identity in 408 aa overlap); and to AL049826|SCH24_20 from Streptomyces coelicolor (425 aa), FASTA scores: opt: 725, E(): 0, (36.1% identity in 418 aa overlap). Also similarity with several MACROLIDE-EFFLUX PROTEINS e.g. from S. pyogenes (405 aa),FASTA scores: E(): 1.3e-06, (22.8% identity in 416 aa overlap). X2BDU7,P0A5C2 No cell wall and cell processes Rv0037c NC_002945.3 Mycobrowser_v2 CDS 2275182 2275838 . + 0 Mb2072 lppI Probable lipoprotein lppI Mb2072, lppI, len: 218 aa. Equivalent to Rv2046,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Probable lppI,lipoprotein contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7VES3 No cell wall and cell processes Rv2046 NC_002945.3 Mycobrowser_v2 CDS 41288 41896 . + 0 Mb0039 conserved protein Mb0039, -, len: 202 aa. Equivalent to Rv0038, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein, equivalent to MLCB1770_16|Q50191|Y038_MYCLE hypothetical 22.0 kDa from Mycobacterium leprae (202 aa), FASTA scores: opt: 1194,E(): 0, (88.6% identity in 202 aa overlap). Also highly similar or similar to other hypothetical proteins e.g. CAB72194.1|AL138851|SCE59.07c from Streptomyces coelicolor (193 aa); AAC06288.1|AF050466 from Mycobacterium bovis (82 aa) (similarity in N-terminus); NP_224347.1|NC_000922|YqgE from Chlamydophila pneumoniae (188 aa); YQGE_ECOLI HYPOTHETICAL 20.7 KD PROTEIN (187 aa), FASTA score: (29.5% identity in 166 aa overlap); etc. X2BDV3 No conserved hypotheticals Rv0038 NC_002945.3 Mycobrowser_v2 CDS 42417 43349 . - 0 Mb0041c mtc28 SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE RICH 28 KDA ANTIGEN) Mb0041c, mtc28, len: 310 aa. Equivalent to Rv0040c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). mtc28, secreted proline rich 28 kDa antigen protein (has hydrophobic stretch at N-terminus) (see citation below). Highly similar to O33075|PR28_MYCLE|MT10019 Proline rich 28 kDa antigen from Mycobacterium leprae (278 aa), FASTA scores: opt: 1007, E(): 0, (65.0% identity in 257 aa overlap); and Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 putative lipoprotein from Mycobacterium leprae (218 aa). C-terminal part very similar to lipoprotein Rv1016c from Mycobacterium tuberculosis. X2BDU6 No NC_002945.3 Mycobrowser_v2 CDS 58576 59070 . + 0 Mb0055 ssb single-strand binding protein ssb (helix-destabilizing protein) Mb0055, ssb, len: 164 aa. Equivalent to Rv0054,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Probable ssb,single-strand binding protein, equivalent to highly similar to others e.g. SSB_MYCLE|P46390 single-strand binding protein from Mycobacterium leprae (140 aa), FASTA scores: opt: 792, E(): 0, (92.6% identity in 135 aa overlap); and AAK30583.1|AF349434 single-stranded DNA-binding protein from Mycobacterium smegmatis (165 aa). Also highly similar to others e.g. T36594 probable single-strand binding protein from Streptomyces coelicolor (199 aa); etc. Also similar to Rv2478c|MTV008_34c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (161 aa), FASTA score: E (): 1.1e-06. Note that the putative product of this CDS corresponds to spot 3_210 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). BELONGS TO THE SSB FAMILY. X2BDW1,P0A611 No information pathways Rv0054 NC_002945.3 Mycobrowser_v2 CDS 43546 46455 . + 0 Mb0042 leuS PROBABLE LEUCYL-tRNA SYNTHETASE LEUS (LEUCINE--tRNA LIGASE) (LEURS) Mb0042, leuS, len: 969 aa. Equivalent to Rv0041,len: 969 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 969 aa overlap). Probable leucyl-tRNA synthetase (EC 6.1.1.4), equivalent to NP_301156.1|NC_002677|MLCB628_3 leucyl-tRNA synthase from Mycobacterium leprae (972 aa), FASTA score: (83.6% identity in 972 aa overlap); and highly similar to MLCB1770_20 from Mycobacterium leprae (824 aa), FASTA score: (82.8% identity in 824 aa overlap). Also highly similar to others e.g. CAB66249.1|AL136518 leucyl-tRNA synthetase from Streptomyces coelicolor (966 aa); NP_244147.1|NC_002570 leucyl-tRNA synthetase from Bacillus halodurans (806 aa); SYL_BACSU|P36430 leucyl-tRNA synthetase from Bacillus subtilis (804 aa), FASTA scores: opt: 714, E(): 3.1e-38, (43.7% identity in 938 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. X2BDV0,P67511 No information pathways Rv0041 NC_002945.3 Mycobrowser_v2 CDS 46565 47191 . - 0 Mb0043c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MARR-FAMILY) Mb0043c, -, len: 208 aa. Equivalent to Rv0042c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Possible transcriptional regulatory protein, MarR-family, highly similar except in N-terminus to CAC32228.1|AL583926 putative MarR-family regulatory protein from Mycobacterium leprae (243 aa). Also similar in part to others e.g. AB76343.1|AL158061 putative MarR-family transcriptional regulator from Streptomyces coelicolor (163 aa); NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (164 aa); NP_531782.1|NC_003304 transcriptional regulator, MarR family from Agrobacterium tumefaciens (151 aa); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv2327, Rv0880, and Rv1404. Q7U2Z1 No regulatory proteins Rv0042c NC_002945.3 Mycobrowser_v2 CDS 241710 242120 . + 0 Mb0209 POSSIBLE EXPORTED PROTEIN Mb0209, -, len: 136 aa. Equivalent to Rv0203, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Possible exported protein (has hydrophobic stretch near N-terminus). Some similarity to part of U02459|LDU02459_1 hypothetical protein from Leishmania donovani (741 aa), FASTA score: opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap). Q7U2K8 No cell wall and cell processes Rv0203 NC_002945.3 Mycobrowser_v2 CDS 47350 48084 . - 0 Mb0044c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0044c, -, len: 244 aa. Equivalent to Rv0043c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable transcriptional regulator, GntR family, similar to others e.g. NP_420584.1|NC_002696 transcriptional regulator GntR family from Caulobacter crescentus (221 aa); NP_294539.1|NC_001263 transcriptional regulator GntR family from Deinococcus radiodurans (267 aa); YIN1_STRAM|P32425 hypothetical transcriptional regulatory protein from Streptomyces ambofaciens (236 aa), FASTA scores: opt: 170, E(): 9.8e-05, (27.6% identity in 127 aa overlap); etc. Similar also to SC9B10_7 from Streptomyces coelicolor FASTA score: E():0.00038; and Rv0165c|MTCI28_5 from Mycobacterium tuberculosis (264 aa), FASTA score: (27.7% identity in 130 aa overlap). X2BDV8,P67738 No regulatory proteins Rv0043c NC_002945.3 Mycobrowser_v2 CDS 48217 49011 . - 0 Mb0045c POSSIBLE OXIDOREDUCTASE Mb0045c, -, len: 264 aa. Equivalent to Rv0044c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar to AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase from Streptomyces lavendulae (264 aa). Also similar to Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c,Rv0791c, Rv0132c, etc. Q7U2Z0 No intermediary metabolism and respiration Rv0044c NC_002945.3 Mycobrowser_v2 CDS 49027 49923 . - 0 Mb0046c POSSIBLE HYDROLASE Mb0046c, -, len: 298 aa. Equivalent to Rv0045c, len 298 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 298 aa overlap). Possible hydrolase (EC 3.-.-.-), showing similarity with others eg NP_107230.1|NC_002678 putative hydrolase from Mesorhizobium loti (278 aa); CAB56730.1|AL121600 putative hydrolase from Streptomyces coelicolor (302 aa); NP_438361.1|NC_000907 putative esterase/lipase from Haemophilus influenzae Rd (287 aa); etc. Also similar to Mycobacterium tuberculosis proteins Rv3473c, Rv1123c,Rv1938, Rv3617, Rv3670, etc. Q7U2Y9 No lipid metabolism Rv0045c NC_002945.3 Mycobrowser_v2 CDS 4344372 4344749 . - 0 Mb3954c rnpA RIBONUCLEASE P PROTEIN COMPONENT RNPA (RNaseP PROTEIN) (RNase P PROTEIN) (PROTEIN C5) Mb3954c, rnpA, len: 125 aa. Equivalent to Rv3923c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). rnpA, ribonuclease P protein component (EC 3.1.26.5) (see citations below),equivalent, but longer ~10 aa, to P46610|RNPA_MYCLE|ML2712 RIBONUCLEASE P PROTEIN COMPONENT from Mycobacterium leprae (120 aa), FASTA scores: opt: 456, E(): 3.3e-24, (63.0% identity in 119 aa overlap); and Q9L7L9|RNPA from Mycobacterium paratuberculosis (119 aa), FASTA scores: opt: 426, E(): 3.5e-22, (60.65% identity in 122 aa overlap). Also similar to many e.g. P25817|RNPA_STRBI from Streptomyces bikiniensis (123 aa), FASTA scores: opt: 174,E(): 4.2e-05, (36.8% identity in 125 aa overlap); P25814|RNPA_BACSU from Bacillus subtilis (116 aa) FASTA scores: opt: 168, E(): 0.0001, (26.85% identity in 108 aa overlap); P48206|RNPA_STRCO|STH24.03 from Streptomyces coelicolor (123 aa), FASTA scores: opt: 166, E(): 0.00015,(37.6% identity in 125 aa overlap); etc. Contains PS00648 Bacterial Ribonuclease P protein component signature. BELONGS TO THE RNPA FAMILY. X2BQ52,P0A5X9 No NC_002945.3 Mycobrowser_v2 CDS 1287656 1287940 . - 0 Mb1191c unknown protein Mb1191c, -, len: 94 aa. Equivalent to Rv1159A, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Hypothetical unknown protein. X2BH61,P0A5S3 No conserved hypotheticals Rv1159A NC_002945.3 Mycobrowser_v2 CDS 364523 364825 . + 0 Mb0307 HYPOTHETICAL PROTEIN Mb0307, -, len: 100 aa. Equivalent to Rv0299, len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 100 aa overlap). Hypothetical unknown protein. Equivalent to AAK44536.1 from Mycobacterium tuberculosis strain CDC1551 (49 aa) but longer 51 aa. Q7U2B8 No conserved hypotheticals Rv0299 NC_002945.3 Mycobrowser_v2 CDS 50005 51108 . - 0 Mb0047c ino1 MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase) Mb0047c, ino1, len: 367 aa. Equivalent to Rv0046c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 367 aa overlap). ino1 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below), equivalent to Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity in 366 aa overlap). N-terminus similar to N-terminus of myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 myo-inositol-1-phosphate synthase (510 aa), FASTA scores: opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); CAC21218.1|AJ401007 myo-inositol 1P synthase from Thermotoga sp. SG1 (335 aa); etc. Also highly similar to other hypothetical proteins e.g. AL049826|SCH24_21c hypothetical protein from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1790, E(): 0, (77.8% identity in 360 aa overlap); AE000881_1 conserved protein from M. thermoautotrophicus (368 aa); etc. X2BDV5,P59967 No NC_002945.3 Mycobrowser_v2 CDS 51169 51711 . - 0 Mb0048c conserved protein Mb0048c, -, len: 180 aa. Equivalent to Rv0047c,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 180 aa overlap). Conserved hypothetical protein, equivalent to NP_302717.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (180 aa). Also showing strong similarity to other hypothetical proteins e.g. AL049826|SCH24_22|T36587 from Streptomyces coelicolor (225 aa), FASTA scores: opt: 583,E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some similarity to Rv1176c from Mycobacterium tuberculosis and to P94443|YFIO from Bacillus subtilis (182 aa), FASTA scores: E(): 0.00066, (24.9% identity in 177 aa overlap). Also some similarity to G1163121 MITHRAMYCIN RESISTANCE DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores: opt: 143, E(): 0.0091, (29.4% identity in 180 aa overlap). Q7U2Y8 No conserved hypotheticals Rv0047c NC_002945.3 Mycobrowser_v2 CDS 53221 55689 . + 0 Mb0051 ponA1 PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE) Mb0051, ponA1, len: 822 aa. Equivalent to penicillin-binding protein, len: 822 aa, from Mycobacterium bovis strain AN5, (99% identity in 821 aa overlap), Equivalent to penicillin-binding protein from Mycobacterium bovis BCG strain Korea 1168P (99% identity in 821 aa overlap), penicillin-binding protein from Mycobacterium tuberculosis strain CDC1551 (99% identity in 817 aa overlap), bifunctional penicillin-binding protein 1A/1B ponA1: penicillin-insensitive transglycosylase + penicillin-sensitive transpeptidase from Mycobacterium tuberculosis strain F11 (99% identity with 819 aa overlap). Probable ponA1, penicillin-binding protein (class A), bienzymatic protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities,highly similar to many e.g. NP_302715.1|NC_002677 penicillin-binding protein from Mycobacterium leprae (708 aa); AAB53123.1|L39923 penicillin binding protein from Mycobacterium leprae (686 aa), FASTA scores: (82.3% identity in 679 aa overlap); Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 penicillin-binding protein 1 from Mycobacterium smegmatis (715 aa) (see citation below); CAB88838.1|AL353832 probable penicillin-binding protein from Streptomyces coelicolor (756 aa); etc. Also similar to ponA2|Rv3682|MTV025.030 BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B from Mycobacterium tuberculosis (810 aa). BELONGS TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION. UPDATE: 5' annotation extension based on de novo proteomics from Mycobacterium tuberculosis strain H37Rv under exponential conditions (See Schubert et al., 2013). Mb0051 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BDV7 No NC_002945.3 Mycobrowser_v2 CDS 55686 57368 . + 0 Mb0052 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0052, -, len: 560 aa. Equivalent to Rv0051,len:560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable conserved transmembrane protein, equivalent to NP_302714.1|NC_002677 conserved membrane protein from Mycobacterium leprae (564 aa); and highly similar to C-terminus of AAF25828.1|AF187306_1|AF187306 putative transmembrane protein from Mycobacterium smegmatis (692 aa). Also highly similar to MSGDNAB_5|G886306|L222-ORF5 (418 aa), FASTA scores: opt: 2163, E(): 0, (78.4% identity in 412 aa overlap). Also similar to AL049826|SCH24_24|T36589 probable transmembrane protein from Streptomyces coelicolor (502 aa), FASTA scores: opt: 492, E(): 1.4e-23,(35.8% identity in 522 aa overlap). Q7U2Y5 No cell wall and cell processes Rv0051 NC_002945.3 Mycobrowser_v2 CDS 57400 57963 . + 0 Mb0053 conserved protein Mb0053, -, len: 187 aa. Equivalent to Rv0052, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Conserved hypothetical protein, similar to others e.g. AL049587|SC5F2A_30S|T35272 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 531,E(): 3.4e-29, (49.5% identity in 182 aa overlap); NP_420588.1|NC_002696 ThiJ/PfpI family protein from Caulobacter crescentus (267 aa); etc. Some similarity to Escherichia coli G1100872|thiJ (198 aa), FASTA scores: opt: 178, E(): 6.1e-06, (29.9% identity in 137 aa overlap). Also similar to Rv1930c from Mycobacterium tuberculosis (174 aa). May be a membrane protein. Q7U2Y4 No conserved hypotheticals Rv0052 NC_002945.3 Mycobrowser_v2 CDS 60386 63010 . + 0 Mb0059 dnaB PROBABLE REPLICATIVE DNA HELICASE DNAB Mb0059, dnaB, len: 874 aa. Equivalent to Rv0058,len: 874 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 874 aa overlap). Probable dnaB,replicative DNA helicase (EC 3.6.1.-). Contains an intein (position 61630..62838) similar to, and in the same position as, those in Sycnechocystis and Rhodothermus marinus (see citation below). Highly similar to others e.g. DNAB_SYNY3|Q55418 replicative dna helicase (872 aa),FASTA scores: opt: 533, E(): 0, (32.5% identity in 424 aa overlap). Also similar to intein recA|E1173867|AL008967 RECA INTEIN from Mycobacterium tuberculosis (442 aa),FASTA scores: E(): 3.8e-16, (27.0% identity in 426 aa overlap). C-terminal extein (position 62839..63015) similar to many dnaB proteins e.g. NP_302709.1|NC_002677|P46394|DNAB_MYCLE REPLICATIVE DNA HELICASE from Mycobacterium leprae (604 aa); DNAB_ECOLI|P03005 replicative dna helicase from Escherichia coli (471 aa), FASTA scores: opt: 148, E(): 1.5e-07, (37.9% identity in 58 aa overlap); etc. THIS PROTEIN UNDERGOES A PROTEIN SELF SPLICING THAT INVOLVES A POST-TRANSLATIONAL EXCISION OF THE INTERVENING REGION (INTEIN) FOLLOWED BY PEPTIDE LIGATION. BELONGS TO THE HELICASE FAMILY, DNAB SUBFAMILY. IN THE INTEIN SECTION; BELONGS TO THE HOMING ENDONUCLEASE FAMILY. X2BDX5,P59966 No information pathways Rv0058 NC_002945.3 Mycobrowser_v2 CDS 63190 63882 . + 0 Mb0060 HYPOTHETICAL PROTEIN Mb0060, -, len: 230 aa. Equivalent to Rv0059, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Hypothetical unknown protein. Q7U2Y3 No conserved hypotheticals Rv0059 NC_002945.3 Mycobrowser_v2 CDS 63899 64957 . + 0 Mb0061 CONSERVED HYPOTHETICAL PROTEIN Mb0061, -, len: 352 aa. Equivalent to Rv0060, len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein, showing weak similarity to NP_104623.1|NC_002678 hypothetical protein from Mesorhizobium loti (155 aa); and AP000062|AP000062_92 hypothetical protein from Aeropyrum pernix (194 aa), FASTA scores: opt: 186, E(): 4.2e-05, (30.9% identity in 165 aa overlap). Q7U2Y2 No conserved hypotheticals Rv0060 NC_002945.3 Mycobrowser_v2 CDS 65002 65340 . - 0 Mb0062A Hypothetical protein Mb0062A, len: 112 aa. Equivalent to Rv0061c len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein supported by RNA-seq data. Similar to MMAR_3839, 76% identity in 112 aa overlap. Replaces questionable ORF Rv0061 (MTV030.04). X2BDW9 No conserved hypotheticals Rv0061c NC_002945.3 Mycobrowser_v2 CDS 309099 309842 . - 0 Mb0265c CONSERVED HYPOTHETICAL PROTEIN Mb0265c, -, len: 247 aa. Equivalent to Rv0259c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 247 aa overlap). Conserved hypothetical protein, showing some similarity to Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis (281 aa), FASTA scores: E(): 9.5e-16, (33.6 % identity in 235 aa overlap). Also some similarity with CAC33938.1|AL589708 putative secreted protein from Streptomyces coelicolor (248 aa). Q7U2F6 No conserved hypotheticals Rv0259c NC_002945.3 Mycobrowser_v2 CDS 66913 68352 . + 0 Mb0064 POSSIBLE OXIDOREDUCTASE Mb0064, -, len: 479 aa. Equivalent to Rv0063, len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase from Arthrobacter oxidans (458 aa), FASTA scores: opt: 343,E(): 3.4e-13, (27.4% identity in 467 aa overlap); AAD28454.1|AF127374_9|AF127374|MitR oxidase from Streptomyces lavendulae (514 aa); AAF81732.1|AF254925|EncM putative FAD-dependent oxygenase from Streptomycesmaritimus (464 aa); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3107c, Rv1257c,etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site. Q7U2X9 No intermediary metabolism and respiration Rv0063 NC_002945.3 Mycobrowser_v2 CDS 68610 71549 . + 0 Mb0065 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0065, -, len: 979 aa. Equivalent to Rv0064, len: 979 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 979 aa overlap). Probable conserved transmembrane protein, highly similar to NP_301532.1| (NC_002677) putative integral membrane protein from Mycobacterium leprae (983 aa). Also similar to other hypothetical proteins from ARCHAEOGLOBUS FULGIDUS and Synecocystis sp. e.g. P72637|D90899 HYPOTHETICAL 117.2 KD PROTEIN from SYNECHOCYSTIS SP. (1032 aa), FASTA scores: opt: 1004, E(): 3.6e-32, (31.0 % identity in 848 aa overlap); and CAC01334.1|AL390968 putative integral membrane protein (fragment) from Streptomyces coelicolor (815 aa); etc. Also similar to Rv3193c from Mycobacterium tuberculosis (992 aa), FASTA score: (50.3% identity in 985 aa overlap). Contains probable coiled-coil domain from aa 948 to 976. X2BDX2,Q7U2X8 No cell wall and cell processes Rv0064 NC_002945.3 Mycobrowser_v2 CDS 71616 71855 . + 0 Mb0065A vapB1 Possible antitoxin VapB1 Mb0065A, len: 79 aa. Equivalent to Rv0064A len: 79 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 79 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB1,antitoxin, part of toxin-antitoxin (TA) operon with Rv0065 (See Arcus et al., 2005; Pandey and Gerdes, 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv0300 (73 aa),Rv1721c (75 aa) X2BDX1 No virulence, detoxification, adaptation Rv0064A NC_002945.3 Mycobrowser_v2 CDS 71848 72249 . + 0 Mb0066 vapc1 possible toxin vapc1 Mb0066, -, len: 133 aa. Equivalent to Rv0065, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis: Rv0960 (127 aa),Rv1720c (129 aa), and Rv0549c (137 aa). Q7U2X7 No virulence, detoxification, adaptation Rv0065 NC_002945.3 Mycobrowser_v2 CDS 72301 74538 . - 0 Mb0067c icd2 PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) Mb0067c, icd2, len: 745 aa. Equivalent to Rv0066c,len: 745 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 745 aa overlap). Probable icd2,isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42),equivalent to NP_302705.1|NC_002677 isocitrate dehydrogenase [NADP] from Mycobacterium leprae (746 aa). Also highly similar to many members of the monomeric-type family of IDH e.g. NP_251314.1|NC_002516 isocitrate dehydrogenase from Pseudomonas aeruginosa (741 aa); IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106,E(): 0, (61.4% identity in 735 aa overlap); NP_230786.1|NC_002505 isocitrate dehydrogenase [Vibrio cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FAMILY OF IDH. Q7U2X6 No NC_002945.3 Mycobrowser_v2 CDS 74656 75225 . - 0 Mb0068c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0068c, -, len: 189 aa. Equivalent to Rv0067c,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 189 aa overlap). Possible transcriptional regulator, highly similar except in N-terminus to T44726 probable transcription regulator from Mycobacterium leprae (189 aa), FASTA scores: opt: 829,E(): 0, (68.3% identity in 189 aa overlap). And similar to others, often many members of the tetR family, e.g. T36918 probable transcription regulator from Streptomyces coelicolor (202 aa); NP_535866.1|NC_003306 transcriptional regulator TetR family from Agrobacterium tumefaciens strain C58 (Dupont) (194 aa); UIDR_ECOLI|Q59431 uid operon repressor (gus operon repressor) from Escherichia coli (196 aa), FASTA scores: opt: 200, E(): 7.2e-06, (24.7% identity in 186 aa overlap); etc. Also similar to MTCY8D5_28 from Mycobacterium tuberculosis cosmid (229 aa), FASTA score: (32.7% identity in 168 aa overlap). Contains probable helix-turn-helix motif from aa 34 to 55 (Score 1523, +4.37 SD). Q7U2X5 No regulatory proteins Rv0067c NC_002945.3 Mycobrowser_v2 CDS 75328 76239 . + 0 Mb0069 PROBABLE OXIDOREDUCTASE Mb0069, -, len: 303 aa. Equivalent to Rv0068, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Probable oxidoreductase (EC 1.-.-.-), equivalent to NP_301343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (304 aa). Also highly similar to many e.g. NP_485762.1|NC_003272 probable oxidoreductase from Nostoc sp. PCC 7120 (311 aa); NP_279536.1|NC_002607|YajO1 probable oxidoreductase from Halobacterium sp. NRC-1 (316 aa); OXIR_STRAT|Q03326 probable oxidoreductase from Streptomyces antibioticus (298 aa), FASTA scores: opt: 430, E(): 1.3e-16, (34.9% identity in 295 aa overlap); etc. Also highly similar to MTV037_3 and MTV022_13 from Mycobacterium tuberculosis. Q7U2X4 No intermediary metabolism and respiration Rv0068 NC_002945.3 Mycobrowser_v2 CDS 76264 77649 . - 0 Mb0070c sdaA PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE DEAMINASE) (SDH) (L-SD) Mb0070c, sdaA, len: 461 aa. Equivalent to Rv0069c,len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable sdaA,L-serine dehydratase (EC 4.3.1.17), equivalent to NP_302203.1| NC_002677 L-serine dehydratase from Mycobacterium leprae (458 aa). Also highly similar to many e.g. NP_251133.1|NC_002516 L-serine dehydratase from Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO L-SERINE DEHYDRATASE from Streptomyces coelicolor (455 aa); SDHL_ECOLI|P16095 L-serine dehydratase 1 from Escherichia coli (454 aa), FASTA scores: opt: 1381, E(): 0, (51.1% identity in 460 aa overlap); etc. BELONGS TO THE IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE). X2BDX6,P66774 No NC_002945.3 Mycobrowser_v2 CDS 89610 89954 . + 0 Mb0084 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0084, -, len: 114 aa. Equivalent to Rv0081, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Probable transcriptional regulator, highly similar to others e.g. AL078610|SCH35_52|T36657 probable transcription regulator from Streptomyces coelicolor (117 aa), FASTA scores: opt: 404, E(): 4.8e-22, (58.2% identity in 110 aa overlap); AAG02351.1|AF210249_10|AF210249 metal-dependent regulatory protein from Streptomyces verticillus (113 aa); NP_435817.1|NC_003037 Putative transcriptional regulator from Sinorhizobium meliloti (115 aa); etc. Q7U2W1 No regulatory proteins Rv0081 NC_002945.3 Mycobrowser_v2 CDS 103745 104698 . - 0 Mb0097c CONSERVED HYPOTHETICAL PROTEIN Mb0097c, -, len: 317 aa. Equivalent to Rv0094c,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(97.8% identity in 317 aa overlap). Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (49.4% identity in 79 aa overlap). Q7U2V3 No insertion seqs and phages Rv0094c NC_002945.3 Mycobrowser_v2 CDS 77646 78923 . - 0 Mb0071c glyA2 serine hydroxymethyltransferase glya2 (serine methylase 2) (shmt 2) Mb0071c, glyA2, len: 425 aa. Equivalent to Rv0070c,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Probable glyA2, serine hydroxymethyltransferase (EC 2.1.2.1), equivalent to NP_302318.1|NC_002677 serine hydroxymethyltransferase from Mycobacterium leprae (426 aa). Also highly similar to many e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE from Streptomyces coelicolor (420 aa); AAK60516.1|AF327063_1|AF327063 serine hydroxymethyltransferase from Corynebacterium glutamicum (434 aa); GLYA_ECOLI|P00477 serine hydroxymethyltransferase from Escherichia coli (417 aa),FASTA scores: opt: 1462, E(): 0, (54.3% identity in 416 aa overlap); etc. Also highly similar to MTV017_46 from Mycobacterium tuberculosis. Contains PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE. X2BDX9,Q7U2X3 No NC_002945.3 Mycobrowser_v2 CDS 79513 80229 . + 0 Mb0072 POSSIBLE MATURASE Mb0072, -, len: 238 aa. Equivalent to Rv0071, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 238 aa overlap). Possible maturase,similar to many proteins of the group II intron maturase family e.g. P95451|U77945 MATURASE-RELATED PROTEIN from PSEUDOMONAS ALCALIGENES (297 aa), FASTA scores: opt: 395,E(): 1.7e-20, (43.5% identity in 147 aa overlap); N-terminus of AAD16434.1|AF101076 maturase-related protein from Pseudomonas putida (473 aa); N-terminus of NP_437373.1|NC_003078 putative reverse transcriptasematurase protein from Sinorhizobium meliloti (453 aa); etc. Also similar to MLCL581_1 from Mycobacterium leprae. Contains 5 VDP repeats at N-terminus, these are also found in two Streptococcus plasmid hypothetical proteins Q52246|X17092 and Q54942|X66468. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp insertion (*-cggtggacc) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (238 aa versus 235 aa). Q7U2X2 No information pathways Rv0071 NC_002945.3 Mycobrowser_v2 CDS 80660 81709 . + 0 Mb0073 PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb0073, -, len: 349 aa. Equivalent to Rv0072, len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Probable glutamine-transport transmembrane protein ABC-transporter (see citation below), showing weak similarity to NP_465894.1|NC_003210 protein similar to putative ABC-transporter transmembrane subunit from Listeria monocytogenes EGD-e (367 aa); NP_471800.1|NC_003212 protein similar to putative ABC-transporter transmembrane subunit from Listeria innocua (367 aa); E1204111|AJ003195 MEMBRANE SPANNING SUBUNIT DEVC from ANABAENA VARIABILIS (385 aa), FASTA scores: opt: 155, E(): 8.1e-07, (22.0% identity in 381 aa overlap). Also highly similar to Rv2563|Y0A5_MYCTU|Q50735|MTCY9C4.05c from Mycobacterium tuberculosis (388 aa), FASTA scores: E(): 0, (76.2% identity in 349 aa overlap). Note that supposed act with near ORF Rv0073|MTV030.17 ATP-binding protein ABC-transporter. Q7U2X1 No cell wall and cell processes Rv0072 NC_002945.3 Mycobrowser_v2 CDS 81712 82554 . + 0 Mb0074 PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER GLNQ Mb0074, -, len: 280 aa. Equivalent to 5' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (94.9% identity in 275 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075. Q7U2X0 No NC_002945.3 Mycobrowser_v2 CDS 82491 82703 . + 0 Mb0075 PROBABLE GLUTAMINE-TRANSPORT PROTEIN ABC TRANSPORTER GLNQ Mb0075, -, len: 70 aa. Equivalent to 3' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 70 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075. No NC_002945.3 Mycobrowser_v2 CDS 86563 87168 . + 0 Mb0080 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0080, -, len: 201 aa. Equivalent to Rv0078, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Probable transcriptional regulator, equivalent to NP_302706.1|NC_002677 putative TetR-family transcriptional regulator from Mycobacterium leprae (236 aa), FASTA scores: opt: 755, E(): 0, (71.4% identity in 175 aa overlap). Also similar to others e.g. NP_103770.1|NC_002678 probable transcriptional regulator from Mesorhizobium loti (208 aa); NP_384275.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (197 aa); NP_250960.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (196 aa); etc. Also similar to TETC_ECOLI|P28815 transposon tn10 tetc protein from Escherichia coli (197 aa), FASTA scores: opt: 181, E(): 9.7e-05, (24.8% identity in 165 aa overlap). Contains probable helix-turn-helix motif from aa 35 to 56 (Score 1348, +3.78 SD). Q7U2W5 No regulatory proteins Rv0078 NC_002945.3 Mycobrowser_v2 CDS 87833 88039 . - 0 Mb0081A Conserved protein Mb0081A, len: 68 aa. Equivalent to Rv0078B len: 68 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 68 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BDY8 No conserved hypotheticals Rv0078B NC_002945.3 Mycobrowser_v2 CDS 88239 89060 . + 0 Mb0082 unknown protein Mb0082, -, len: 273 aa. Equivalent to Rv0079, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Hypothetical unknown protein. Q7U2W3 No conserved hypotheticals Rv0079 NC_002945.3 Mycobrowser_v2 CDS 89057 89515 . + 0 Mb0083 CONSERVED HYPOTHETICAL PROTEIN Mb0083, -, len: 152 aa. Equivalent to Rv0080, len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 152 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Streptomyces coelicolor e.g. SCJ12.26|AL109989|SCJ12_24 from Streptomyces coelicolor cosmid J1 (137 aa), FASTA scores: opt: 291, E(): 4e-13, (46.5% identity in 129 aa overlap); etc. Q7U2W2 No conserved hypotheticals Rv0080 NC_002945.3 Mycobrowser_v2 CDS 89959 90438 . + 0 Mb0085 PROBABLE OXIDOREDUCTASE Mb0085, -, len: 159 aa. Equivalent to Rv0082, len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 159 aa overlap). Probable oxidoreductase (EC 1.-.-.-), highly highly similar or similar to other various oxidoreductases e.g. NP_143304.1|NC_000961 NADH-ubiquinone oxidoreductase subunit from Pyrococcus horikoshii (173 aa); NP_126406.1|NC_000868 CO-induced hydrogenase related,subunit L from Pyrococcus abyssi (170 aa); HYCG_ECOLI|P16433 formate hydrogenlyase subunit 7 from Escherichia coli (255 aa), FASTA scores: opt: 442, E(): 8e-29, (43.2% identity in 148 aa overlap); etc. Q7U2W0 No intermediary metabolism and respiration Rv0082 NC_002945.3 Mycobrowser_v2 CDS 90435 92363 . + 0 Mb0086 PROBABLE OXIDOREDUCTASE Mb0086, -, len: 642 aa. Equivalent to Rv0083, len: 640 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 640 aa overlap). Probable oxidoreductase (EC 1.-.-.-), showing some similarity to other various oxidoreductases e.g. AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa); HYFB_ ECOLI|P23482 hydrogenase-4 component b from Escherichia coli strain K12 (672 aa), FASTA scores: opt: 995, E(): 0,(32.2% identity in 571 aa overlap); AAF13041.1|AF157639_1|AF157639 putative formate hydrogenlyase integral membrane subunit from Desulfitobacterium dehalogenans (637 aa); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Q7U2V9 No intermediary metabolism and respiration Rv0083 NC_002945.3 Mycobrowser_v2 CDS 92363 93313 . + 0 Mb0087 hycD POSSIBLE FORMATE HYDROGENLYASE HYCD (FHL) Mb0087, hycD, len: 316 aa. Equivalent to Rv0084,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 316 aa overlap). Possible hycD (alternate gene name: hevD), formate hydrogenlyase (EC 1.-.-.-), integral membrane protein, similar to others e.g. HYCD_ECOLI|P16430 formate hydrogenlyase subunit 4 from Escherichia coli (307 aa), FASTA scores: opt: 570,E(): 2.1e-26, (33.8% identity in 305 aa overlap); AAK06856.1|AF335723_2|AF335723 formate hydrogenlyase subunit 4 from Burkholderia pseudomallei (316 aa); NP_457244.1|NC_003198 formate hydrogenlyase subunit 4 from Salmonella enterica subsp. enterica serovar Typhi (307 aa); etc. Also similar to NUOH_ECOLI|P33603 NADH dehydrogenase I chain H from Escherichia coli (325 aa),FASTA scores: opt: 207, E(): 9.5e-06, (26.5% identity in 260 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY. Q7U2V8 No intermediary metabolism and respiration Rv0084 NC_002945.3 Mycobrowser_v2 CDS 93324 93986 . + 0 Mb0088 hycP POSSIBLE HYDROGENASE HYCP Mb0088, hycP, len: 220 aa. Equivalent to Rv0085,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Possible hycP,hydrogenase (EC 1.-.-.-), integral membrane protein,weakly similar to P77524|HYFE_ECOLI HYDROGENASE-4 COMPONENT E from Escherichia coli (216 aa), FASTA scores: opt: 204, E():1.2e-07, (25.5% identity in 216 aa overlap). X2BDZ6,P64682 No intermediary metabolism and respiration Rv0085 NC_002945.3 Mycobrowser_v2 CDS 162834 163439 . - 0 Mb0140c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0140c, -, len: 201 aa. Equivalent to Rv0135c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Possible transcriptional regulator, weakly similar to others e.g. P32398|YHGD_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Bacillus subtilis (191 aa), FASTA scores: opt: 145,E(): 0.0012, (21.0% identity in 162 aa overlap). Q7U2S1 No regulatory proteins Rv0135c NC_002945.3 Mycobrowser_v2 CDS 93986 95452 . + 0 Mb0089 hycQ POSSIBLE HYDROGENASE HYCQ Mb0089, hycQ, len: 488 aa. Equivalent to Rv0086,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Possible hycQ,hydrogenase (EC 1.-.-.-), integral membrane protein,weakly similar to P77437|HYFF_ECOLI HYDROGENASE-4 COMPONENT F from Escherichia coli (526 aa), FASTA scores: opt: 948, E(): 0, (35.9% identity in 493 aa overlap); and AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa). Also similar to d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L from Escherichia coli (613 aa), FASTA scores: opt: 360,E():3.2e-13, (27.9% identity in 488 aa overlap); and to NUON_ECOLI|P33608 NADH dehydrogenase I chain N from Escherichia coli (425 aa), FASTA scores: opt: 375, E(): 3.9e-14, (25.0% identity in 432 aa overlap). Q7U2V7 No intermediary metabolism and respiration Rv0086 NC_002945.3 Mycobrowser_v2 CDS 95449 96927 . + 0 Mb0090 hycE possible formate hydrogenase hyce (fhl) Mb0090, hycE, len: 492 aa. Equivalent to Rv0087,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Possible hycE (alternate gene name: hevE), formate hydrogenlyase (EC 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate hydrogenlyase subunit 5 from Escherichia coli (569 aa),FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in 449 aa overlap); NP_457243.1|NC_003198 formate hydrogenlyase subunit 5 from Salmonella enterica subsp. enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 formate hydrogenlyase subunit 5 from Methanothermobacter thermautotrophicus (370 aa); etc. Also some similarity with NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from Escherichia coli (407 aa), FASTA scores: opt: 245, E(): 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO THE COMPLEX I 49 kDa SUBUNIT FAMILY. Q7U2V6 No intermediary metabolism and respiration Rv0087 NC_002945.3 Mycobrowser_v2 tRNA 4153262 4153350 . - 0 serT serT tRNA-Ser serT, len: 89 nt. Equivalent to serT, len: 89 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 nt overlap). tRNA-Ser, anticodon gct. No NC_002945.3 Mycobrowser_v2 CDS 97793 98386 . + 0 Mb0092 POSSIBLE METHYLTRANSFERASE/METHYLASE Mb0092, -, len: 197 aa. Equivalent to Rv0089, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Possible methyltransferase (EC 2.1.1.-), showing some weak similarity to others e.g. NP_299749.1|NC_002488 3-demethylubiquinone-9 3-methyltransferase from Xylella fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative methyltransferase from Streptomyces coelicolor (285 aa); NP_111415.1|NC_002689 Predicted SAM-dependent methyltransferase from Thermoplasma volcanium (245 aa); etc. Also some similarity with many biotin biosynthesis proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. X2BE12,P65347 No intermediary metabolism and respiration Rv0089 NC_002945.3 Mycobrowser_v2 CDS 98515 99285 . + 0 Mb0093 POSSIBLE MEMBRANE PROTEIN Mb0093, -, len: 256 aa. Equivalent to Rv0090, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible membrane protein. X2BE01,P64684 No cell wall and cell processes Rv0090 NC_002945.3 Mycobrowser_v2 CDS 885641 886240 . - 0 Mb0813c HYPOTHETICAL PROTEIN Mb0813c, -, len: 199 aa. Equivalent to Rv0789c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Hypothetical unknown protein. Q7U198 No conserved hypotheticals Rv0789c NC_002945.3 Mycobrowser_v2 CDS 99719 100486 . + 0 Mb0094 mtn probable bifunctional mta/sah nucleosidase mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + s-adenosylhomocysteine nucleosidase (s-adenosyl-l-homocysteine homocysteinylribohydrolase) Mb0094, mtn, len: 255 aa. Equivalent to Rv0091,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Probable mtn (alternate gene name: pfs), MTA/SAH nucleosidase,including 5'-methylthioadenosine nucleosidase (EC 3.2.2.16) and S-adenosylhomocysteine nucleosidase (EC 3.2.2.9), similar to others e.g. NP_521493.1|NC_003295 PROBABLE BIFUNCTIONAL PROTEIN (MTA/SAH NUCLEOSIDASE) (P46): 5'-METHYLTHIOADENOSINE NUCLEOSIDASE AND S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from Ralstonia solanacearum (261 aa); AAC45731.1|U55214 Pfs from Treponema pallidum (249 aa); P96122|MTN_TREPA MTA/SAH NUCLEOSIDASE from Treponema pallidum (269 aa); PFS_ECOLI|P24247 pfs protein (p46) from Escherichia coli (232 aa), FASTA scores: opt: 214, E(): 3.8e-08, (30.5% identity in 246 aa overlap); etc. BELONGS TO THE MTN FAMILY. X2BE00,P67657 No intermediary metabolism and respiration Rv0091 NC_002945.3 Mycobrowser_v2 CDS 100618 102903 . + 0 Mb0095 ctpA cation transporter p-type atpase a ctpa Mb0095, ctpA, len: 761 aa. Equivalent to Rv0092,len: 761 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 761 aa overlap). Probable ctpA,cation-transporting P-type ATPase A (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. CTPA_MYCLE|P46839 cation-transporting P-type ATPase A from Mycobacterium leprae (780 aa), FASTA scores: opt: 3454,E(): 0, (74.4% identity in 741 aa overlap); CAB66270.1|AL136519 probable cation-transporting P-type ATPase from Streptomyces coelicolor (760 aa); NP_391230.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); etc. Also highly similar to MTCY251.22c from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain,and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES),SUBFAMILY IB. Q7U2V5 No cell wall and cell processes Rv0092 NC_002945.3 Mycobrowser_v2 CDS 419978 420637 . + 0 Mb0357 HYPOTHETICAL PROTEIN Mb0357, -, len: 219 aa. Equivalent to Rv0349, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Hypothetical unknown protein. Q7U273 No conserved hypotheticals Rv0349 NC_002945.3 Mycobrowser_v2 CDS 104469 105251 . - 0 Mb0098c CONSERVED HYPOTHETICAL PROTEIN Mb0098c, -, len: 260 aa. Equivalent to Rv1588 and Rv0095c, len: 222 aa and 136 aa, from Mycobacterium tuberculosis strain H37Rv, (98.2% identity in 222 aa overlap and 92.5% identity in 134 aa overlap). Member of 13E12 repeat, also partially similar to AF0418|AF041819_8 from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% identity in 96 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Q7U2V2 No Rv1588 NC_002945.3 Mycobrowser_v2 CDS 105360 106751 . + 0 Mb0099 PPE1 ppe family protein ppe1 Mb0099, PPE1, len: 463 aa. Equivalent to Rv0096,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 463 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. Z46257|MLACEA_3 aceA gene for isocitrate L from M. leprae (438 aa), FASTA scores: opt: 1207, E(): 0, (55.3% identity in 380 aa overlap). Also similar to Z97559|MTCY261_19 from Mycobacterium tuberculosis (473 aa), FASTA score: (40.2% identity in 478 aa overlap); YHS6_MYCTU|P42611 hypothetical 50.6 kd protein (517 aa),FASTA scores: opt: 365, E(): 4.6e-12, (37.6% identity in 178 aa overlap). Also similar to MTCY274.23c from M. tuberculosis FASTA score: (31.1% identity in 383 overlap). Some similarity also to MTCY31.06c and MTCY48.17 and other mycobacterial PPE family proteins. Q7U2V1 No PE/PPE Rv0096 NC_002945.3 Mycobrowser_v2 CDS 106770 107639 . + 0 Mb0100 POSSIBLE OXIDOREDUCTASE Mb0100, -, len: 289 aa. Equivalent to Rv0097, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to NP_302343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (289 aa). Also highly similar to BAB69377.1|AB070955 putative oxidoreductase from Streptomyces avermitilis (296 aa); and weakly similar to others e.g. NP_518867.1|NC_003295 PUTATIVE ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE OXIDOREDUCTASE PROTEIN from Ralstonia solanacearum (301 aa); NP_286110.1|NC_002655 taurine dioxygenase (2-oxoglutarate-dependent) from Escherichia coli strain O157:H7 (283 aa); NP_252624.1|NC_002516 taurine dioxygenase from Pseudomonas aeruginosa (277 aa); ECAE00014310 (283 aa), FASTA scores: opt: 304, E(): 2.6e-13, (27.8% identity in 288 aa overlap); TFDA_ALCEU|P10088 2,4-dichlorophenoxyacetate monooxygenase from A. eutropha (287 aa), FASTA scores: opt: 188, E(): 3.5e-06, (26.6% identity in 188 aa overlap); etc. Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature. X2BE10,P67756 No intermediary metabolism and respiration Rv0097 NC_002945.3 Mycobrowser_v2 CDS 107636 108187 . + 0 Mb0101 fcot probable fatty acyl coa thioesterase type iii fcot Mb0101, -, len: 183 aa. Equivalent to Rv0098, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, equivalent to CAC30948.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (183 aa). Also some similarity with BAB69378.1|AB070955 hypothetical protein from Streptomyces avermitilis (172 aa). X2BE08 No lipid metabolism Rv0098 NC_002945.3 Mycobrowser_v2 CDS 122353 123867 . + 0 Mb0107 CONSERVED HYPOTHETICAL PROTEIN Mb0107, -, len: 504 aa. Equivalent to Rv0104, len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 504 aa overlap). Conserved hypothetical protein, showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta regulatory subunit from Homo sapiens (380 aa); etc. Q7U2U8 No conserved hypotheticals Rv0104 NC_002945.3 Mycobrowser_v2 CDS 108192 109814 . + 0 Mb0102 fadD10 POSSIBLE FATTY-ACID-COA LIGASE FADD10 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0102, fadD10, len: 540 aa. Equivalent to Rv0099,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). Possible fadD10,fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to MLACEA_4|Q50176 LONG CHAIN FATTY ACID-COA LIGASE from Mycobacterium leprae (532 aa), FASTA scores: opt: 2580,E(): 0, (74.6% identity in 531 aa overlap). Also similar to many e.g. BAB69379.1|AB070955 long-chain fatty acid--CoA ligase from Streptomyces avermitilis (518 aa); NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (530 aa); NP_435326.1|NC_003037 probable long chain fatty acid CoA ligase from Sinorhizobium meliloti (508 aa); etc. Also similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase from Bacillus subtilis (572 aa), FASTA scores: opt: 415,E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains PS00455 putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U2V0 No NC_002945.3 Mycobrowser_v2 CDS 109819 110055 . + 0 Mb0103 CONSERVED HYPOTHETICAL PROTEIN Mb0103, -, len: 78 aa. Equivalent to Rv0100,(MTCY251.19), len: 78 aa. Conserved hypothetical protein,equivalent only to CAC30950.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (78 aa). X2BE11 No NC_002945.3 Mycobrowser_v2 CDS 161962 162345 . + 0 Mb0139-1 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-1, -, len: 128 aa. Pseudogene part1 of Rv0134/ephF No NC_002945.3 Mycobrowser_v2 CDS 162345 162452 . + 0 Mb0139-2 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-2, -, len: 36 aa. Pseudogene part2 of Rv0134/ephF No NC_002945.3 Mycobrowser_v2 CDS 110037 117575 . + 0 Mb0104 nrp PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) Mb0104, nrp, len: 2512 aa. Equivalent to Rv0101,len: 2512 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2512 aa overlap). Probable nrp,peptide synthetase (EC 6.-.-.-), similar to others e.g. AAD44234.1|AF143772_40|PstB peptide synthetase from Mycobacterium avium (2552 aa); 7476034|S77657 cyclic peptide synthetase from Mycobacterium leprae (1401 aa),FASTA scores: opt: 4268, E(): 0, (65.7% identity in 1091 aa overlap); part of CAB55600.1|AJ238027 peptide synthetase from Mycobacterium smegmatis (5990). Also similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF protein from Bacillus subtilis (2378 aa); SRF1_BACSU|P27206 surfactin synthetase subunit 1 (3587 aa), FASTA scores: opt: 1708, E(): 0, (30.6% identity in 1633 aa overlap): etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), 2 x PS00455 Putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. THOUGHT TO BE NOT INVOLVED IN MYCOBACTIN BIOSYNTHESIS (see citation below). Q7U2U9 No lipid metabolism Rv0101 NC_002945.3 Mycobrowser_v2 CDS 117750 119735 . + 0 Mb0105 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0105, -, len: 661 aa. Equivalent to Rv0102, len: 661 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 661 aa overlap). Probable conserved integral membrane protein, highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium leprae (659 aa), FASTA scores: opt: 3107, E(): 0, (70.2% identity in 662 aa overlap). Also similar to others e.g. CAC01497.1|AL391017 putative integral membrane protein from Streptomyces coelicolor (316 aa); etc. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. X2BE16,P64690 No cell wall and cell processes Rv0102 NC_002945.3 Mycobrowser_v2 CDS 119951 122209 . - 0 Mb0106c ctpB PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB Mb0106c, ctpB, len: 752 aa. Equivalent to Rv0103c,len: 752 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 752 aa overlap). Probable ctpB,cation-transporting P-type ATPase B (transmembrane protein) (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 cation-transporting P-type ATPase B from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% identity in 752 aa overlap). Also highly similar to others e.g. CAB96031.1|AL360055 putative metal transporter ATPase from Streptomyces coelicolor (753 aa); NP_241423.1|NC_002570 copper-transporting ATPase from Bacillus halodurans (806 aa); etc. Also highly similar to Z46257|MLACEA_7 aceA gene for isocitrate L from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615,E():0, (76.5% identity in 752 aa overlap). And similar to MTCY251.11 from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain, PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. X2BE13,P59947 No NC_002945.3 Mycobrowser_v2 CDS 124016 124300 . - 0 Mb0108c rpmB1 50s ribosomal protein l28-1 rpmb1 Mb0108c, rpmB1, len: 94 aa. Equivalent to Rv0105c,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Probable rpmB1, 50S ribosomal protein L28-1, highly similar to others e.g. Q9X8K8|R28B_STRCO 50S RIBOSOMAL PROTEIN L28-2 from Streptomyces coelicolor (78 aa); RL28_ECOLI|P02428 50s ribosomal protein l28 from Escherichia coli (77 aa), FASTA scores: opt: 167, E(): 6.2e-06, (40.7% identity in 59 aa overlap); etc. Also similar to MTCY63A_2 from Mycobacterium tuberculosis. BELONGS TO THE L28P FAMILY OF RIBOSOMAL PROTEINS. X2BE14,P0A5V7 No NC_002945.3 Mycobrowser_v2 CDS 124410 125606 . + 0 Mb0109 CONSERVED HYPOTHETICAL PROTEIN Mb0109, -, len: 398 aa. Equivalent to Rv0106, len: 398 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 398 aa overlap). Conserved hypothetical protein, similar to others e.g. AL049841|SCE9_33 from Streptomyces coelicolor (370 aa),FASTA scores: opt: 282, E(): 2.5e-11, (32.0% identity in 381 aa overlap); etc. Some similarity to P94400 HOMOLOGUE TO NITRILE HYDRATASE REGION from Bacillus subtilis (397 aa), FASTA scores: opt: 226, E(): 5.4e-08, (26.4% identity in 405 aa overlap). Also similar to COBW_PSEDE|P29937 FASTA score: (25.3% identity in 186 aa overlap); and P47K_PSECL|P31521 47 kd protein (p47k) (419 aa), FASTA score: (25.9% identity in 401 aa overlap). X2BE15 No conserved hypotheticals Rv0106 NC_002945.3 Mycobrowser_v2 CDS 704058 704444 . + 0 Mb0623 HYPOTHETICAL PROTEIN Mb0623, -, len: 128 aa. Equivalent to Rv0607, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Hypothetical unknown protein. Q7U1M9 No conserved hypotheticals Rv0607 NC_002945.3 Mycobrowser_v2 CDS 125701 130578 . - 0 Mb0111c ctpI PROBABLE CATION-TRANSPORTER ATPASE I CTPI Mb0111c, ctpI, len: 1625 aa. Equivalent to 5' end of Rv0107c, len: 1632 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1572 aa overlap). Probable ctpI, cation-transporting ATPase I P-type (EC 3.6.3.-), highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium leprae (1609 aa); and similar to others e.g. CAB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 603, E(): 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium tuberculosis, FASTA score: (34.4% identity in 796 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-t) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U2U7 No NC_002945.3 Mycobrowser_v2 CDS 130932 131141 . - 0 Mb0112c HYPOTHETICAL PROTEIN Mb0112c, -, len: 69 aa. Equivalent to Rv0108c, len: 69 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 69 aa overlap). Hypothetical unknown protein. Q7U2U6 No conserved hypotheticals Rv0108c NC_002945.3 Mycobrowser_v2 CDS 383909 384571 . - 0 Mb0322c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0322c, -, len: 220 aa. Equivalent to Rv0314c,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 220 aa overlap). Possible conserved membrane protein, with hydrophobic stretch from residues ~75-100. Similar in C-terminal part to Mycobacterium tuberculosis proteins Rv0679c and Rv0680c. Q7U2A3 No cell wall and cell processes Rv0314c NC_002945.3 Mycobrowser_v2 CDS 162696 162863 . + 0 Mb0139-4 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-4, -, len: 55 aa. Pseudogene part4 of Rv0134/ephF. No NC_002945.3 Mycobrowser_v2 CDS 131420 132910 . + 0 Mb0113 PE_PGRS1 pe-pgrs family protein pe_pgrs1 Mb0113, PE_PGRS1, len: 496 aa. Equivalent to Rv0109, len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 496 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. Q50615|Y0DP_MYCTU HYPOTHETICAL GLYCINE-RICH 40.8 KD PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1772, E(): 0, (57.3% identity in 513 aa overlap); etc. Q7U2U5 No PE/PPE Rv0109 NC_002945.3 Mycobrowser_v2 CDS 167901 168827 . + 0 Mb0147 CONSERVED HYPOTHETICAL PROTEIN Mb0147, -, len: 308 aa. Equivalent to Rv0142, len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). Q7U2R6 No conserved hypotheticals Rv0142 NC_002945.3 Mycobrowser_v2 CDS 133058 133807 . + 0 Mb0114 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0114, -, len: 249 aa. Equivalent to Rv0110, len 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Probable conserved integral membrane protein, similar to many e.g. AL079308|SCH69_25 from Streptomyces coelicolor (297 aa),FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity in 251 aa overlap); P54493|YQGP_BACSU HYPOTHETICAL 56.4 KD PROTEIN from Bacillus subtilis (507 aa), FASTA scores: opt: 320, E(): 4e-15, (32.4% identity in 210 aa overlap); etc. Q7U2U4 No cell wall and cell processes Rv0110 NC_002945.3 Mycobrowser_v2 CDS 133988 136045 . + 0 Mb0115 POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE Mb0115, -, len: 685 aa. Equivalent to Rv0111, len: 685 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 685 aa overlap). Possible transmembrane acyltransferase (EC 2.3.1.-), equivalent to AA22904.1|AL035300 putative acyltransferase from Mycobacterium leprae (696 aa). Also similar to others e.g. C69975 acyltransferase homolog yrhL from Bacillus subtilis (634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4% identity in 382 aa overlap). Very similar to Mycobacterium tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc. Q7U2U3 No intermediary metabolism and respiration Rv0111 NC_002945.3 Mycobrowser_v2 CDS 136327 137283 . + 0 Mb0116 gca POSSIBLE GDP-MANNOSE 4,6-DEHYDRATASE GCA (GDP-D-MANNOSE DEHYDRATASE) Mb0116, gca, len: 318 aa. Equivalent to Rv0112,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Possible gca,GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21,(27.0% identity in 318 aa overlap). Similar to Rv3634c,Rv3784, etc from Mycobacterium tuberculosis. Contains PS00061 Short-chain dehydrogenases/reductases family signature. SEEMS TO BELONG TO THE GDP-MANNOSE 4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+). Q7U2U2 No cell wall and cell processes Rv0112 NC_002945.3 Mycobrowser_v2 CDS 137357 137947 . + 0 Mb0117 gmhA probable sedoheptulose-7-phosphate isomerase gmha (phosphoheptose isomerase) Mb0117, gmhA, len: 196 aa. Equivalent to Rv0113,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable gmhA (alternate gene name: lpcA), phosphoheptose isomerase (EC 5.-.-.-), similar to many e.g. AE0005|HPAE000596_11 from Helicobacter pylori (192 aa), FASTA scores: opt: 451, E(): 1.9e-24, (45.1% identity in 162 aa overlap). BELONGS TO THE SIS FAMILY, LPCA SUBFAMILY. X2BE22,P0A605 No cell wall and cell processes Rv0113 NC_002945.3 Mycobrowser_v2 CDS 137979 138551 . + 0 Mb0118 gmhb possible d-alpha,beta-d-heptose-1,7-biphosphate phosphatase gmhb (d-glycero-d-manno-heptose 7-phosphate kinase) Mb0118, -, len: 190 aa. Equivalent to Rv0114, len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 190 aa overlap). Possible dehydratase (EC 4.-.-.-), similar to several hypothetical proteins and to HIS7_ECOLI|P06987 imidazoleglycerol-phosphate dehydratase (355 aa), FASTA scores: opt: 250, E(): 3.6e-11, (34.0 % identity in 141 aa overlap). X2BE37,Q7U2U1 No cell wall and cell processes Rv0114 NC_002945.3 Mycobrowser_v2 CDS 138702 139619 . + 0 Mb0119 hdda possible d-alpha-d-heptose-7-phosphate kinase hdda Mb0119, -, len: 305 aa. Equivalent to Rv0115, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(98.5% identity in 275 aa overlap). Possible sugar kinase (EC 2.-.-.-), similar to several hypothetical proteins and sugar kinases e.g. AAK27850.1|AF324836_3 D-glycero-D-manno-heptose 7-phosphate kinase from Aneurinibacillus thermoaerophilus (341 aa); AAK80995.1|AE007802_11 Sugar kinase from Clostridium acetobutylicum (364 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U2U0 No cell wall and cell processes Rv0115 NC_002945.3 Mycobrowser_v2 CDS 140307 141062 . - 0 Mb0120c ldta probable l,d-transpeptidase ldta Mb0120c, -, len: 251 aa. Equivalent to Rv0116c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Possible conserved membrane protein, showing similarity to several hypothetical mycobacterial proteins e.g. Rv1433 from Mycobacterium tuberculosis (271 aa); and Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa); to the C-terminal regions of others like Rv0192 from Mycobacterium tuberculosis (366 aa), FASTA scores: opt: 451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7% identity in 221 aa overlap). TBparse score is 0.932. Q7U2T9 No cell wall and cell processes Rv0116c NC_002945.3 Mycobrowser_v2 CDS 161060 161665 . + 0 Mb0138 gcn5-related n-acetyltransferase Mb0138, -, len: 201 aa. Equivalent to Rv0133, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Putative acetyltransferase (EC 2.3.1.-), highly similar to others e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 aa), FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity in 201 aa overlap). Q7U2S2 No intermediary metabolism and respiration Rv0133 NC_002945.3 Mycobrowser_v2 CDS 141240 142184 . + 0 Mb0121 oxyS OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN OXYS Mb0121, oxyS, len: 314 aa. Equivalent to Rv0117,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). OxyS, oxidative stress response protein regulatory protein, LysR family (see citation below). Similar to many transcription regulators and OxyR, the oxidative stress response protein of many bacteria. Contains LysR family signature at N-terminus. Also contains helix-turn-helix motif at aa 16-37 (Score 1543, +4.44 SD). BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. OXYR IS REQUIRED FOR THE INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES SUCH AS CATALASE, GLUTATHIONE-REDUCTASE, ETC. Q7U2T8 No regulatory proteins Rv0117 NC_002945.3 Mycobrowser_v2 CDS 142168 143916 . - 0 Mb0122c oxcA PROBABLE OXALYL-COA DECARBOXYLASE OXCA Mb0122c, oxcA, len: 582 aa. Equivalent to Rv0118c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 582 aa overlap). Probable oxcA,oxalyl-CoA decarboxylase (EC 4.1.1.8), highly similar to many e.g. P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 PROBABLE OXALYL-CoA DECARBOXYLASE from Escherichia coli (564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from Oxalobacter formigenes (568 aa), FASTA scores: opt: 2124,E():0, (55.6% identity in 568 aa overlap). Also similar to mycobacterial IlvB proteins e.g. MLCB1788.46c unknown TPP-requiring enzyme from Mycobacterium leprae (548 aa); and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa),FASTA scores: opt: 831, E(): 0, (33.9% identity in 567 aa overlap). Q7U2T7 No NC_002945.3 Mycobrowser_v2 CDS 1791019 1791366 . + 0 Mb1632 hisI Probable phosphoribosyl-AMP 1,6 cyclohydrolase hisI Mb1632, hisI, len: 115 aa. Equivalent to Rv1606,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Probable hisI,phosphoribosyl-AMP 1,6 cyclohydrolase (EC 3.5.4.19),similar to several e.g. X82010|RSHISI_2 HISI from Rhodobacter sphaeroides (119 aa), FASTA scores: opt: 378,E(): 2.8e-21, (52.3% identity in 109 aa overlap); etc. X2BIF1,P0A5B4 No intermediary metabolism and respiration Rv1606 NC_002945.3 Mycobrowser_v2 CDS 144089 145666 . + 0 Mb0123 fadD7 PROBABLE FATTY-ACID-COA LIGASE FADD7 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0123, fadD7, len: 525 aa. Equivalent to Rv0119,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable fadD7,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to 4-coumarate:CoA ligase of many organisms e.g. U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus taedaxylem (537 aa), FASTA scores: opt: 483, E(): 8.3e-22,(28.2% identity in 440 aa overlap). Contains PS00455 Putative AMP-binding domain signature. TBscore is 0.896. Q7U2T6 No NC_002945.3 Mycobrowser_v2 CDS 167461 167871 . - 0 Mb0146c unknown protein Mb0146c, -, len: 136 aa. Equivalent to Rv0141c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Hypothetical unknown protein. Q7U2R7 No conserved hypotheticals Rv0141c NC_002945.3 Mycobrowser_v2 CDS 152515 154320 . + 0 Mb0131 treS TREHALOSE SYNTHASE TRES Mb0131, treS, len: 601 aa. Equivalent to Rv0126,len: 601 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 601 aa overlap). treS, trehalose synthase (EC 5.4.99.-) (see citation below), highly similar to others e.g. CAA04601.2|AJ001205 putative trehalose synthase from Streptomyces coelicolor (566 aa); S71450|1536814|BAA11303.1|D78198 trehalose synthase maltose-specific from Pimelobacter sp. strain R48 (573 aa). Also similar to MAL1_DROME|P07191 possible maltase precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7% identity in 504 aa overlap); and similar to proteins associated with amino-acid transport e.g. Q64319 rat protein which stimulates transport of cystine and dibasic and neutral amino acids (683 aa), FASTA scores: opt: 839,E(): 0, (32.0% identity in 531 aa overlap). Also similar to several other Mycobacterium tuberculosis proteins e.g. Rv2471 FASTA score: (31.7% identity in 164 aa overlap). Q7U2S8 No virulence, detoxification, adaptation Rv0126 NC_002945.3 Mycobrowser_v2 CDS 154423 155790 . + 0 Mb0132 mak maltokinase mak Mb0132, -, len: 455 aa. Equivalent to Rv0127, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 455 aa overlap). Conserved hypothetical protein, highly similar to various proteins e.g. AJ0012|SCJ001205_4 hypothetical protein from Streptomyces coelicolor A3(2) (464 aa), FASTA scores: opt: 412, E(): 1.1e-19, (40.6% identity in 485 aa overlap); AJ0012|SCJ001206_5 hypothetical protein from Streptomyces coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E(): 4.3 e-19, (36.5% identity in 455 aa overlap). X2BE38,Q7U2S7 No virulence, detoxification, adaptation Rv0127 NC_002945.3 Mycobrowser_v2 CDS 145667 147460 . - 0 Mb0124c fusA2b PROBABLE ELONGATION FACTOR G FUSA2B [SECOND PART] (EF-G) Mb0124c, fusA2b, len: 597 aa. Equivalent to 3' end of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 597 aa overlap). Probable fusA2 (alternate gene name: fus2), elongation factor G,highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia coli (703 aa), FASTA scores: opt: 1049, E(): 0, (32.5% identity in 717 aa overlap). Also similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FASTA score: (39.1% identity in 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G (EF-G) from Mycobacterium leprae (701 aa), FASTA score: (31.7% identity in 710 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fusA2 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (gc-t), splits fusA2 into 2 parts, fusA2a and fusA2b. Q7U2T5 No NC_002945.3 Mycobrowser_v2 CDS 197852 198721 . + 0 Mb0174 yrbE1B conserved integral membrane protein yrbe1b Mb0174, yrbE1B, len: 289 aa. Equivalent to Rv0168,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). yrbE1B, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 223,E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc. Q7U2P0 No NC_002945.3 Mycobrowser_v2 CDS 250316 251794 . + 0 Mb0216 HYPOTHETICAL PROTEIN Mb0216, -, len: 492 aa. Equivalent to Rv0210, len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. Q7U2K2 No conserved hypotheticals Rv0210 NC_002945.3 Mycobrowser_v2 CDS 147457 147810 . - 0 Mb0125c fusA2a PROBABLE ELONGATION FACTOR G FUSA2A [FIRST PART] (EF-G) Mb0125c, fusA2a, len: 117 aa. Equivalent to 5' end of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 108 aa overlap). Probable fusA2 (alternate gene name: fus2), elongation factor G,highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia coli (703 aa), FASTA scores: opt: 1049, E(): 0, (32.5% identity in 717 aa overlap). Also similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FASTA score: (39.1% identity in 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G (EF-G) from Mycobacterium leprae (701 aa), FASTA score: (31.7% identity in 710 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fusA2 exists as a single gene. In Mycobacterium bovis, a frameshift due to the substitution of a single base (gc-t), splits fusA2 into 2 parts, fusA2a and fusA2b. Q7U2T4 No NC_002945.3 Mycobrowser_v2 CDS 147946 148380 . - 0 Mb0126c conserved protein Mb0126c, -, len: 144 aa. Equivalent to Rv0121c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Conserved hypothetical protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155,Rv1875, Rv2074, etc. Q7U2T3 No conserved hypotheticals Rv0121c NC_002945.3 Mycobrowser_v2 CDS 148529 148897 . + 0 Mb0127 HYPOTHETICAL PROTEIN Mb0127, -, len: 122 aa. Equivalent to Rv0122, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical unknown protein. Q7U2T2 No conserved hypotheticals Rv0122 NC_002945.3 Mycobrowser_v2 CDS 148894 149262 . + 0 Mb0128 unknown protein Mb0128, -, len: 122 aa. Equivalent to Rv0123, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical unknown protein. Q7U2T1 No conserved hypotheticals Rv0123 NC_002945.3 Mycobrowser_v2 CDS 149571 151187 . + 0 Mb0129 PE_PGRS2 pe-pgrs family protein pe_pgrs2 Mb0129, PE_PGRS2, len: 538 aa. Similar to Rv0124,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(87.4% identity in 547 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1730, E(): 0, (60.7% identity in 504 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa). Q7U2T0 No NC_002945.3 Mycobrowser_v2 CDS 151339 152406 . + 0 Mb0130 pepA probable serine protease pepa (serine proteinase) (mtb32a) Mb0130, pepA, len: 355 aa. Equivalent to Rv0125,len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 355 aa overlap). Probable pepA, serine protease (EC 3.4.21.-), highly similar to other proteases e.g. HHOB_ECOLI|P31137 protease hhob precursor (355 aa),FASTA scores: opt: 400, E(): 3.8e-14, (32.4% identity in 346 aa overlap). Also similar to Q50320 34 KDA protein precursor from Mycobacterium tuberculosis (361 aa), FASTA scores: opt: 1689, E(): 0, (70.7% identity in 362 aa overlap). Contains PS00135 Serine proteases, trypsin family, serine active site. Has a possible signal sequence at the N-terminus. Q7U2S9 No intermediary metabolism and respiration Rv0125 NC_002945.3 Mycobrowser_v2 CDS 156769 157791 . - 0 Mb0134c fbpC SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) Mb0134c, fbpC, len: 340 aa. Equivalent to Rv0129c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). fbpC (alternate gene names: mpt45, 85C, fbpC2), secreted antigen 85c (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below), also highly similar to other Mycobacterial antigen precursors e.g. A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1937,E(): 0, (81.4% identity in 333 aa overlap); etc. X2BE42,P0A4V5 No NC_002945.3 Mycobrowser_v2 CDS 158038 158493 . + 0 Mb0135 htdz probable 3-hydroxyl-thioester dehydratase Mb0135, -, len: 151 aa. Equivalent to Rv0130, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, most similar to AL096811|SCI30A_19 from Streptomyces coelicolor (153 aa), FASTA scores: opt: 639, E(): 0, (60.8% identity in 148 aa overlap). Also similar to NODN_RHILV|P08634 nodulation protein from Rhizobium leguminosarum bv. viciae plasmid pRL1JI (161 aa), FASTA scores: opt: 406, E(): 1e-21, (43.9% identity in 148 aa overlap; and to O30041 MONOAMINE OXIDASE REGULATORY PROTEIN (146 aa), FASTA scores: opt: 219, E(): 1.1e-08, (30.8% identity in 133 aa overlap). X2BE39,Q7U2S5 No intermediary metabolism and respiration Rv0130 NC_002945.3 Mycobrowser_v2 CDS 158506 159849 . - 0 Mb0136c fadE1 PROBABLE ACYL-CoA DEHYDROGENASE FADE1 Mb0136c, fadE1, len: 447 aa. Equivalent to Rv0131c,len: 447 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 447 aa overlap). Probable fadE1,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain specific precursor (412 aa), FASTA scores: opt: 522, E(): 1.4e-23, (30.1% identity in 425 aa overlap). Also highly similar to MTCI5_28 from Mycobacterium tuberculosis. Q7U2S4 No NC_002945.3 Mycobrowser_v2 CDS 159891 160973 . - 0 Mb0137c fgd2 putative f420-dependent glucose-6-phosphate dehydrogenase fgd2 Mb0137c, fgd2, len: 360 aa. Equivalent to Rv0132c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 360 aa overlap). Putative fgd2,F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), highly similar to many from Mycobacteria e.g. AAD38167|g5031431 from Mycobacterium chelonae. Also similar to MJ1534|Q58929 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE from METHANOCOCCUS JANNASCHII (342 aa), FASTA scores: opt: 285, E(): 7.9e-11,(28.4% identity in 292 aa overlap). And also similar to Rv0953c, Rv0791c, etc from Mycobacterium tuberculosis. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U2S3 No NC_002945.3 Mycobrowser_v2 CDS 163556 164881 . + 0 Mb0141 cyp138 PROBABLE CYTOCHROME P450 138 CYP138 Mb0141, cyp138, len: 441 aa. Equivalent to Rv0136,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable cyp138,cytochrome P450 138 (EC 1.14.-.-), similar to others e.g. SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 aa), FASTA scores: opt: 315, E(): 1e-13, (25.7% identity in 416 aa overlap); etc. Also similar to MTV039_6 from Mycobacterium tuberculosis (472 aa), FASTA score: (38.2% identity in 442 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BE52,P63718 No NC_002945.3 Mycobrowser_v2 CDS 164902 165450 . - 0 Mb0142c msrA PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) REDUCTASE) Mb0142c, msrA, len: 182 aa. Equivalent to Rv0137c,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable msrA,peptide methionine sulfoxide reductase (EC 1.8.4.6),equivalent to CAC32179.1|AL583926 putative peptide methionine sulfoxide from Mycobacterium leprae (177 aa). Highly similar to others e.g. CAC18703.1|AL451182 putative peptide methionine sulfoxide reductase from Streptomyces coelicolor (172 aa); PMSR_SCHPO|Q09859 putative peptide methionine sulfoxide reductase from Streptomyces (187 aa),FASTA scores: opt: 468, E(): 9.9e-26, (45.6% identity in 158 aa overlap); etc. BELONGS TO THE MSRA FAMILY. X2BE48,P0A5L1 No NC_002945.3 Mycobrowser_v2 CDS 165513 166016 . + 0 Mb0143 CONSERVED HYPOTHETICAL PROTEIN Mb0143, -, len: 167 aa. Equivalent to Rv0138, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 167 aa overlap). Conserved hypothetical protein, showing weak similarity to Q10827|YT10_MYCTU HYPOTHETICAL 17.0 KDA PROTEIN from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 131, E(): 0.047,(31.15% identity in 106 aa overlap). Q7U2S0 No conserved hypotheticals Rv0138 NC_002945.3 Mycobrowser_v2 CDS 166017 167039 . + 0 Mb0144 possible oxidoreductase Mb0144, -, len: 340 aa. Equivalent to Rv0139, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). Putative oxidoreductase (EC 1.-.-.-), similar to others e.g. O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa),FASTA scores: opt: 507, E (): 5.8e-27, (31.1% identity in 328 aa overlap); TRE_STRGR|P29782 dtdp-glucose 4,6-dehydratase (328 aa), FASTA scores: opt: 254, E(): 2.6e-10, (29.0% identity in 307 aa overlap). Q7U2R9 No intermediary metabolism and respiration Rv0139 NC_002945.3 Mycobrowser_v2 CDS 167100 167480 . + 0 Mb0145 conserved protein Mb0145, -, len: 126 aa. Equivalent to Rv0140, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Conserved hypothetical protein, similar to others e.g. P74567|D90916_48 HYPOTHETICAL 20.8 KDP ROTEIN from Synechocystis sp. (180 aa), FASTA scores: opt: 229, E(): 4.7e-10, (36.1% identity in 108 aa overlap). Also similar to Rv1056 and Rv1670 from Mycobacterium tuberculosis. Q7U2R8 No conserved hypotheticals Rv0140 NC_002945.3 Mycobrowser_v2 CDS 168894 170372 . - 0 Mb0148c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0148c, -, len: 492 aa. Equivalent to Rv0143c,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Probable conserved transmembrane protein, CIC family possibly involved in transport of chloride, similar to others and hypothetical proteins e.g. O28857 PUTATIVE CHLORIDE CHANNEL from Archaeoglobus fulgidus (589 aa), FASTA scores: opt: 966,E(): 0, (37.7% identity in 453 aa overlap); YADQ_ECOLI|P37019 hypothetical 46.0 kd protein (436 aa),FASTA scores: opt: 452, E(): 2.4e-20, (28.0% identity in 460 aa overlap). Q7U2R5 No cell wall and cell processes Rv0143c NC_002945.3 Mycobrowser_v2 CDS 249234 250319 . + 0 Mb0215 HYPOTHETICAL PROTEIN Mb0215, -, len: 361 aa. Equivalent to Rv0209, len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 361 aa overlap). Hypothetical unknown protein. Q7U2K3 No conserved hypotheticals Rv0209 NC_002945.3 Mycobrowser_v2 CDS 170474 171316 . + 0 Mb0149 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0149, -, len: 280 aa. Equivalent to Rv0144, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable transcriptional regulator, possibly tetR family. Has region similar to others e.g. Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli strains K12 and O157:H7 (196 aa), FASTA scores: opt: 214, E(): 1.1e-06, (26.0% identity in 196 aa overlap). Contains probable helix-turn helix motif from aa 109-130 (Score 1463, +4.17 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U2R4 No regulatory proteins Rv0144 NC_002945.3 Mycobrowser_v2 CDS 173428 174948 . + 0 Mb0152 probable aldehyde dehydrogenase (nad+) dependent Mb0152, -, len: 506 aa. Equivalent to Rv0147, len: 506 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 506 aa overlap). Probable aldehyde dehydrogenase (NAD+) dependant (EC 1.2.1.-), similar to others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric NADP-preferring) (452 aa), FASTA scores: opt: 1291, E(): 0, (43.9% identity in 453 aa overlap). Also similar to several Mycobacterium tuberculosis aledehyde dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 aldehyde dehydrogenases glutamic acid active site, and PS00070 aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Q7U2R1 No intermediary metabolism and respiration Rv0147 NC_002945.3 Mycobrowser_v2 CDS 175023 175883 . + 0 Mb0153 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb0153, -, len: 286 aa. Equivalent to Rv0148, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable short-chain dehydrogenase (EC 1.-.-.-), similar to others, in particular Estradiol 17 beta-dehydrogenases (EC 1.1.1.62),e.g. DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 (735 aa), FASTA scores: opt: 952, E(): 0, (52.5% identity in 276 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U2R0 No intermediary metabolism and respiration Rv0148 NC_002945.3 Mycobrowser_v2 CDS 175890 176858 . + 0 Mb0154 possible quinone oxidoreductase (nadph:quinone oxidoreductase) (zeta-crystallin) Mb0154, -, len: 322 aa. Equivalent to Rv0149, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 322 aa overlap). Putative quinone oxidoreductase (EC 1.6.5.-), similar to others oxidoreductases e.g. Q08257 quinone oxidoreductase (EC 1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18,(28.4% identity in 328 aa overlap); SCHCOADH_4 from Streptomyces coelicolor. Also similar to many proteins from Mycobacterium tuberculosis. Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. BELONG TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. Q7U2Q9 No intermediary metabolism and respiration Rv0149 NC_002945.3 Mycobrowser_v2 CDS 176855 177142 . - 0 Mb0155c CONSERVED HYPOTHETICAL PROTEIN Mb0155c, -, len: 95 aa. Equivalent to Rv0150c, len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 95 aa overlap). Conserved hypothetical protein, showing some similarity with C-terminus of O53949|Rv1800|MTV049.22 PPE-FAMILY PROTEIN from Mycobacterium tuberculosis (655 aa), FASTA score: (36.5% identity in 104 aa overlap). Q7U2Q8 No conserved hypotheticals Rv0150c NC_002945.3 Mycobrowser_v2 CDS 209895 211004 . - 0 Mb0185c lprO possible lipoprotein lpro Mb0185c, lprO, len: 369 aa. Equivalent to Rv0179c,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 369 aa overlap). Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U2M9 No NC_002945.3 Mycobrowser_v2 CDS 177733 179499 . - 0 Mb0156c PE1 pe family protein pe1 Mb0156c, PE1, len: 588 aa. Equivalent to Rv0151c,len: 588 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 588 aa overlap). Member of the Mycobacterium tuberculosis PE family, with N-terminal region similar to others e.g. MTV032_2 PE_PGRS family from Mycobacterium tuberculosis (468 aa), FASTA scores: opt: 1125, E(): 0, (46.3% identity in 456 aa overlap); MTCY493_24 from M. tuberculosis FASTA score: (42.5% identity in 558 aa overlap). Also similar to upstream ORF MTCI5.26c FASTA score: (54.7% identity in 464 aa overlap). Also shows similarity to C-terminal part of some PPE family proteins e.g. MTV049_21 from Mycobacterium tuberculosis FASTA score: (41.5% identity in 591 aa overlap). Q7U2Q7 No NC_002945.3 Mycobrowser_v2 CDS 179509 181086 . - 0 Mb0157c PE2 pe family protein pe2 Mb0157c, PE2, len: 525 aa. Equivalent to Rv0152c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to ORF downstream Z92770|MTCI5_25 (588 aa), FASTA scores: opt: 1492, E(): 0, (54.7% identity in 464 aa overlap); and to many other PE family type members. Q7U2Q6 No NC_002945.3 Mycobrowser_v2 CDS 181345 182175 . - 0 Mb0158c ptbB PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) Mb0158c, ptbB, len: 276 aa. Equivalent to Rv0153c,len: 276 aa, from Mycobacterium tuberculosis strain H27Rv,(99.6% identity in 276 aa overlap). ptbB (alternate gene name: MPtpB), protein-tyrosine-phosphatase (see citation below) (EC 3.1.3.48), showing some similarity to several protein-tyrosine phosphatases, polyketide synthase and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed a secreted protein. Q7U2Q5 No NC_002945.3 Mycobrowser_v2 CDS 182177 183388 . - 0 Mb0159c fadE2 PROBABLE ACYL-CoA DEHYDROGENASE FADE2 Mb0159c, fadE2, len: 403 aa. Equivalent to Rv0154c,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 403 aa overlap). Probable fadE2,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. C-terminal region of O01590 ACYL-CoA DEHYDROGENASE (974 aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain) (383 aa), FASTA score: (35.0% identity in 306 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7U2Q4 No NC_002945.3 Mycobrowser_v2 CDS 183812 184912 . + 0 Mb0160 pntAa PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAa [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) Mb0160, pntAa, len: 366 aa. Equivalent to Rv0155,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 366 aa overlap). Probable pntAa, first part of NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2), similar to N-terminus of others e.g. PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase subunit alpha from Escherichia coli strain K12 (510 aa),FASTA scores: opt: 921, E(): 0, (42.1% identity in 361 aa overlap); PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA (EC 1.6.1.1). Q7U2Q3 No NC_002945.3 Mycobrowser_v2 CDS 184913 185245 . + 0 Mb0161 pntAb PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAb [SECOND PART; INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) Mb0161, pntAb, len: 110 aa. Equivalent to Rv0156,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 110 aa overlap). Probable pntAb, second part of NAD(P) transhydrogenase subunit alpha, integral membrane protein, similar to C-terminus of others e.g. Q59764 NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAB (139 aa), FASTA scores: opt: 247, E(): 1.9e-11,(45.5% identity in 88 aa overlap). Q7U2Q2 No NC_002945.3 Mycobrowser_v2 CDS 185242 186669 . + 0 Mb0162 pntB PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) Mb0162, pntB, len: 475 aa. Equivalent to Rv0157,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 475 aa overlap). Probable pntB,pyridine nucleotide transhydrogenase (nicotinamide nucleotide transhydrogenase) subunit beta (EC 1.6.1.1),integral membrane protein, similar to others e.g. Q59763 PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity in 472 aa overlap); P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli strains K12 and O157:H7 (462 aa). Q7U2Q1 No intermediary metabolism and respiration Rv0157 NC_002945.3 Mycobrowser_v2 CDS 186685 186813 . - 0 Mb0162A Conserved protein Mb0162A, len: 42 aa. Equivalent to Rv0157A len: 42 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 42 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein,showing similarity to C-terminal part (aa 186-220) of O53976|Rv1975|MTV051.13 conserved hypothetical protein from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 173, E(): 3e-06, (62.5% identity in 40 aa overlap). X2BE85 No conserved hypotheticals Rv0157A NC_002945.3 Mycobrowser_v2 CDS 186975 187619 . + 0 Mb0163 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0163, -, len: 214 aa. Equivalent to Rv0158, len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable transcriptional regulator, possibly TetR family, showing weak similarity to various transcriptional activators and repressors e.g. P32398|YIXD_BACSU|YHGD HYPOTHETICAL TRANSCRIPTIONAL REGULATORY PROTEIN from Bacillus subtilis (191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0% identity in 191 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1296, +3.60 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U2Q0 No regulatory proteins Rv0158 NC_002945.3 Mycobrowser_v2 CDS 187623 189029 . - 0 Mb0164c PE3 pe family protein pe3 Mb0164c, PE3, len: 468 aa. Equivalent to Rv0159c,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 468 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many other PE proteins e.g. O06828 from Mycobacterium tuberculosis (528 aa), FASTA scores: opt: 1163, E(): 0,(45.8% identity in 467 aa overlap). Also highly similar to upstream MTV032_3, and to MTCI5_25, MTCI5_26, MTV049_ 21,MTCY1A10_26, etc. Q7U2P9 No NC_002945.3 Mycobrowser_v2 CDS 189121 190629 . - 0 Mb0165c PE4 pe family protein pe4 Mb0165c, PE4, len: 502 aa. Equivalent to Rv0160c,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 502 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many other PE proteins e.g. Z92770|MTCI5_26c from M. tuberculosis (525 aa), FASTA scores: opt: 816, E(): 0,(41.4% identity in 367 aa overlap); C-terminal region of O06801|RV1768|MTCY28.34 from Mycobacterium tuberculosis (618 aa), FASTA scores: opt: 417, E(): 6.7e-18, (53.5% identity in 142 aa overlap). Also highly similar to downstream ORF MTV032_2. Q7U2P8 No NC_002945.3 Mycobrowser_v2 CDS 190797 192146 . + 0 Mb0166 possible oxidoreductase Mb0166, -, len: 449 aa. Equivalent to Rv0161, len 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 actin interacting protein 2 (530 aa),FASTA scores: opt: 356, E (): 0, (33.3% identity in 357 aa overlap); DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome) (587 aa), FASTA scores: opt: 311, E(): 2.5e-20, (27.9% identity in 366 aa overlap). Also similar to other Mycobacteria proteins e.g. MTCY339.30c from M. tuberculosis FASTA score: (29.4% identity in 357 aa overlap); MLCL622.30c from Mycobacterium tuberculosis (449 aa). Q7U2P7 No intermediary metabolism and respiration Rv0161 NC_002945.3 Mycobrowser_v2 CDS 211084 212442 . - 0 MbXXXXc Mb0186c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN MbXXXXc -, len: 452 aa. Equivalent to Rv0180c, len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 452 aa overlap). Probable conserved transmembrane protein, equivalent to CAC32132.1|AL583926 probable conserved membrane protein from Mycobacterium leprae (465 aa). Shows some similarity with others membrane proteins e.g. AL096849|SCI11_29 from Streptomyces coelicolor (354 aa), FASTA scores: opt: 190, E(): 0.00067,(25.9% identity in 409 aa overlap). Q7U2M8 No cell wall and cell processes Rv0180c NC_002945.3 Mycobrowser_v2 CDS 192174 193325 . - 0 Mb0167c adhE1 probable zinc-type alcohol dehydrogenase (e subunit) adhe1 Mb0167c, adhE1, len: 383 aa. Equivalent to Rv0162c,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Probable adhE1,zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7% identity in 363 aa overlap). Also similar to other alcohol dehydrogenases from Mycobacterium tuberculosis e.g. MTCY369.06c FASTA score: (34.0% identity in 365 aa overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa overlap). Contains PS00059 Zinc-contain ingalcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR: ZINC. Q7U2P6 No NC_002945.3 Mycobrowser_v2 CDS 193307 193762 . + 0 Mb0168 conserved protein Mb0168, -, len: 151 aa. Equivalent to Rv0163, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, similar to others e.g. Q44017 HYPOTHETICAL 16.6 KDA PROTEIN IN GBD 5'REGION (ORF6)from Alcaligenes eutrophus (145 aa), FASTA scores: opt: 155,E(): 0.0002, (26.6% identity in 139 aa overlap). Also weak similary with MTV008.31c|Rv2475c|B70867 from Mycobacterium tuberculosis (138 aa). Q7U2P5 No conserved hypotheticals Rv0163 NC_002945.3 Mycobrowser_v2 CDS 197053 197850 . + 0 Mb0173 yrbE1A conserved integral membrane protein yrbe1a Mb0173, yrbE1A, len: 265 aa. Equivalent to Rv0167,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). yrbE1A, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar or similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa),FASTA scores: opt: 328, E(): 1.8e-15, (26.6% identity in 244 aa overlap); etc. Q7U2P1 No NC_002945.3 Mycobrowser_v2 CDS 207006 207647 . + 0 Mb0181 PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN Mb0181, -, len: 213 aa. Equivalent to Rv0175, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Probable conserved Mce-associated membrane protein, equivalent, but longer in N-terminus, to CAC32127.1|AL583926 possible membrane protein from Mycobacterium leprae (182 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Contains two 12 residue direct repeats at N-terminus. Q7U2N3 No cell wall and cell processes Rv0175 NC_002945.3 Mycobrowser_v2 CDS 194315 195007 . - 0 Mb0170c mce1R Probable transcriptional regulatory protein Mce1R (probably GntR-family) Mb0170c, len: 230 aa. Equivalent to Rv0165c len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(81.2% identity in 218 aa overlap). Probable mce1R,transcriptional regulator, GntR family (See Casali et al.,2006), showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI gluconate operon transcriptional repressor from Bacillus licheniformis (243 aa); GNTR_BACSU gluconate operon repressor from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. Seems to belong to the GntR family of transcriptional regulators. Start changed since first submission (-41 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus. X2BE70 No regulatory proteins Rv0165c NC_002945.3 Mycobrowser_v2 CDS 194334 194513 . - 0 Mb0171c mce1r POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0171c, -, len: 59 aa. Equivalent to 3' end of Rv0165c, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 57 aa overlap). Possible transcriptional regulator, GntR family, showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH part. Mb0171c corresponds to the remnant COOH part of Rv0165c. No NC_002945.3 Mycobrowser_v2 CDS 195185 196849 . + 0 Mb0172 fadD5 PROBABLE FATTY-ACID-CoA LIGASE FADD5 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Mb0172, fadD5, len: 554 aa. Equivalent to Rv0166,len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 554 aa overlap). Probable fadD5,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many eg LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in 534 aa overlap). Also similar to many other fatty-acid-CoA ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c FASTA score: (35.3% identity in 487 aa overlap),MTV013_10, MTY25D10_30, etc. Contains PS00455 putative AMP-binding domain signature. Q7U2P2 No NC_002945.3 Mycobrowser_v2 CDS 212469 213203 . - 0 Mb0187c CONSERVED HYPOTHETICAL PROTEIN Mb0187c, -, len: 244 aa. Equivalent to Rv0181c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd protein from Escherichia coli (231 aa), FASTA scores: opt: 479, E(): 1.2e-29, (37.3% identity in 233 aa overlap); P73623|SLL1773 HYPOTHETICAL 25.7 KD PROTEIN from Synechocystis sp. strain PCC 6803 (232 aa), FASTA score: (39.1% identity in 233 aa overlap). X2BEB5,P65725 No conserved hypotheticals Rv0181c NC_002945.3 Mycobrowser_v2 CDS 198726 200090 . + 0 Mb0175 mce1A MCE-FAMILY PROTEIN MCE1A Mb0175, mce1A, len: 454 aa. Equivalent to Rv0169,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 454 aa overlap). mce1A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene product from Mycobacterium avium (88 aa) (similarity on C-terminus); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Note that equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 Mcep protein from Mycobacterium tuberculosis (432 aa). Contains a very hydrophobic region around residues 20-35. Note that previously known as mce1. Q7U2N9 No NC_002945.3 Mycobrowser_v2 CDS 200087 201127 . + 0 Mb0176 mce1B MCE-FAMILY PROTEIN MCE1B Mb0176, mce1B, len: 346 aa. Equivalent to Rv0170,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 346 aa overlap). mce1B (alternate gene name: mceD); belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa); etc. Contains hydrophobic region in N-terminal 30 residues. In Escherichia coli, N-terminal part is functional and directs export of a leaderless beta-lactamase into the periplasm (see seventh citation). Q7U2N8 No NC_002945.3 Mycobrowser_v2 CDS 201124 202671 . + 0 Mb0177 mce1C MCE-FAMILY PROTEIN MCE1C Mb0177, mce1C, len: 515 aa. Equivalent to Rv0171,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). mce1C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Weakly similar to downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA score: (24.6% identity in 552 aa overlap). Contains possible signal sequence and highly proline-rich C-terminus. Q7U2N7 No NC_002945.3 Mycobrowser_v2 CDS 219678 220109 . + 0 Mb0194 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0194, -, len: 143 aa. Equivalent to Rv0188, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Probable conserved transmembrane protein, similar to T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable membrane protein from Streptomyces coelicolor (147 aa),FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity in 141 aa overlap); N-terminus of P80185|MTRC_METTH TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT C (EC 2.1.1.86) from Methanobacterium thermoautotrophicum strain Marburg/DSM 2133 (266 aa), FASTA scores: opt: 125, E(): 0.033, (31.6% identity in 98 aa overlap). Also similar to Rv3635 from Mycobacterium tuberculosis. Q7U2M1 No cell wall and cell processes Rv0188 NC_002945.3 Mycobrowser_v2 CDS 207644 208612 . + 0 Mb0182 PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE PROTEIN Mb0182, -, len: 322 aa. Equivalent to Rv0176, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 322 aa overlap). Probable conserved Mce-associated transmembrane protein. Contains short region of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 kDa antigen) from Mycobacterium leprae (249 aa) (outside the proline-rich region), FASTA scores: opt: 165, E(): 2.9e-05, (40.0% identity in 65 aa overlap). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv3493c, etc. Q7U2N2 No cell wall and cell processes Rv0176 NC_002945.3 Mycobrowser_v2 CDS 202668 204260 . + 0 Mb0178 mce1D MCE-FAMILY PROTEIN MCE1D Mb0178, mce1D, len: 530 aa. Equivalent to Rv0172,len: 530 aa, fromMycobacterium tuberculosis strain H37Rv,(100.0% identity in 530 aa overlap). mce1D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Hydrophobic region at N-terminus. Q7U2N6 No NC_002945.3 Mycobrowser_v2 CDS 242172 243455 . - 0 Mb0210c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0210c, -, len: 427 aa. Equivalent to Rv0204c,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 412 aa overlap). Probable conserved transmembrane protein, equivalent, but has C-terminal extension, to Z95398|MLCL622.17c from Mycobacterium leprae (367 aa), FASTA scores: opt: 2002, E(): 0, (82.4% identity in 374 aa overlap). Some similarity to Rv0585c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 a versus 412 aa). Q7U2K7 No cell wall and cell processes Rv0204c NC_002945.3 Mycobrowser_v2 CDS 204257 205429 . + 0 Mb0179 lprK POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E) Mb0179, lprK, len: 390 aa. Equivalent to Rv0173,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Possible lprK (alternate gene name: mce1E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains PS00013 prokaryotic membrane lipoprotein lipid attachment site. Q7U2N5 No cell wall and cell processes Rv0173 NC_002945.3 Mycobrowser_v2 CDS 205423 206970 . + 0 Mb0180 mce1F MCE-FAMILY PROTEIN MCE1F Mb0180, mce1F, len: 515 aa. Equivalent to Rv0174,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). mce1F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Has hydrophobic stretch, possibly a signal peptide at the N-terminus. Q7U2N4 No NC_002945.3 Mycobrowser_v2 CDS 208609 209163 . + 0 Mb0183 PROBABLE CONSERVED MCE ASSOCIATED PROTEIN Mb0183, -, len: 184 aa. Equivalent to Rv0177, len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Probable conserved Mce-associated protein, equivalent to CAC32129.1|AL583926 conserved membrane protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv1973, Rv3493c,etc. Q7U2N1 No conserved hypotheticals Rv0177 NC_002945.3 Mycobrowser_v2 CDS 209130 209864 . + 0 Mb0184 PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN Mb0184, -, len: 244 aa. Equivalent to Rv0178, len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable conserved Mce-associated membrane protein, highly similar in C-terminus to CAC32130.1|AL583926 putative secreted protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10 aa overlap with the upstream ORF. Q7U2N0 No cell wall and cell processes Rv0178 NC_002945.3 Mycobrowser_v2 CDS 213220 214332 . - 0 Mb0188c sigG PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR) Mb0188c, sigG, len: 370 aa. Equivalent to Rv0182c,len: 370 aa (start site uncertain; first of several possibles was chosen, but note that this overlaps the upstream ORF), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 370 aa overlap). Probable sigG,alternative RNA polymerase sigma subunit (see citations below), similar to many e.g. Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FACTOR from Bacillus subtilis (187 aa). Also similar to nine other ECF sigma factors from Mycobacterium tuberculosis e.g. Rv1221, Rv0735, etc. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 205-226 (Score 1181, +3.21 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY,ECF SUBFAMILY. Q7U2M7 No NC_002945.3 Mycobrowser_v2 CDS 214280 215119 . + 0 Mb0189 POSSIBLE LYSOPHOSPHOLIPASE Mb0189, -, len: 279 aa. Equivalent to Rv0183, len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Possible lysophospholipase (EC 3.1.-.-), similar to several (especially eukaryotic enzymes, weaker with Escherichia coli), e.g. U67963|HSU67963_1 Human lysophospholipase homolog from Homo sapiens (313 aa), FASTA scores: opt: 569, E(): 2.6e-29, (37.1% identity in 259 aa overlap); P07000|PLDB_ECOLI LYSOPHOSPHOLIPASE L2 from Escherichia coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start changed based on similarity to AE001997_8 from Deinococcus radiodurans (282 aa), FASTA scores: opt: 510, E(): 1.4e-25, (34.8% identity in 282 aa overlap). Also shows some similarity to epoxide hydrolases from Mycobacterium tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in 114 aa overlap); and O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa). Note that the putative product of this CDS corresponds to spot 3_329 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). Q7U2M6 No intermediary metabolism and respiration Rv0183 NC_002945.3 Mycobrowser_v2 CDS 215161 215910 . + 0 Mb0190 CONSERVED HYPOTHETICAL PROTEIN Mb0190, -, len: 249 aa. Equivalent to Rv0184, len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Conserved hypothetical protein, equivalent to CAC32136.1|AL583926 conserved hypothetical protein from Mycobacterium lepra (249 aa); and C-terminus highly similar to CAB08793.1|Z95398 conserved hypothetical protein from Mycobacterium leprae (145 aa), FASTA scores: E(): 0, (75.2 identity in 145 aa overlap). Also similar to 049841|SCE9_39|T36358 hypothetical protein from Streptomyces coelicolor (418 aa), FASTA scores: opt: 231,E(): 8.1e-08, (30.4% identity in 270 aa overlap). Q7U2M5 No conserved hypotheticals Rv0184 NC_002945.3 Mycobrowser_v2 CDS 215907 216416 . + 0 Mb0191 CONSERVED HYPOTHETICAL PROTEIN Mb0191, -, len: 169 aa. Equivalent to Rv0185, len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Conserved hypothetical protein, equivalent to CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in 165 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q7U2M4 No conserved hypotheticals Rv0185 NC_002945.3 Mycobrowser_v2 CDS 216461 218536 . + 0 Mb0192 bglS PROBABLE BETA-GLUCOSIDASE BGLS (GENTIOBIASE) (CELLOBIASE) (BETA-D-GLUCOSIDE GLUCOHYDROLASE) Mb0192, bglS, len: 691 aa. Equivalent to Rv0186,len: 691 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 691 aa overlap). Probable bglS,beta-glucosidase (EC 3.2.1.21), highly similar to many e.g. BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0,(32.5% identity in 842 aa overlap). SEEMS TO BELONG TO FAMILY 3 OF GLYCOSYL HYDROLASES. Q7U2M3 No intermediary metabolism and respiration Rv0186 NC_002945.3 Mycobrowser_v2 CDS 218582 218743 . - 0 Mb0192A mymT Metallothionein, MymT Mb0192A, len: 53 aa. Equivalent to Rv0186A len: 53 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 53 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). MymT,metallothionein,equivalent to MAV_4993|A0QMH5 hypothetical protein from Mycobacterium avium (strain 104) (51 aa), and MAP_3626c|Q73TU2 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (51 aa), FASTA scores: opt: 312, E(): 4.6e-17, (81.2% identity in 48 aa overlap). X2BEB8 No virulence, detoxification, adaptation Rv0186A NC_002945.3 Mycobrowser_v2 CDS 218897 219559 . + 0 Mb0193 PROBABLE O-METHYLTRANSFERASE Mb0193, -, len: 220 aa. Equivalent to Rv0187, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable O-methyltransferase (EC 2.1.1.-), similar to many e.g. AB93458.1|AL357591 putative O-methyltransferase from Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719 O-methyltransferase from Streptomyces mycarofaciens (221 aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity in 192 aa overlap). Also similar to Rv1703c, Rv1220c from Mycobacterium tuberculosis. Q7U2M2 No intermediary metabolism and respiration Rv0187 NC_002945.3 Mycobrowser_v2 CDS 220188 221915 . - 0 Mb0195c ilvD PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) Mb0195c, ilvD, len: 575 aa. Equivalent to Rv0189c,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 575 aa overlap). Probable ilvD,dihydroxy-acid dehydratase (EC 4.2.1.9), similar to many e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (570 aa), FASTA scores: opt: 1605, E(): 0, (46.0% identity in 561 aa overlap). Also similar to ML2608|MLCL622.06c|O06069|ILVD_MYCLE DIHYDROXY-ACID DEHYDRATASE from Mycobacterium leprae (564 aa). Contains PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. BELONGS TO THE ILVD / EDD FAMILY. COFACTOR: BINDS 1 4FE-4S CLUSTER (POTENTIAL). X2BEA6,P65155 No NC_002945.3 Mycobrowser_v2 CDS 222481 223722 . + 0 Mb0197 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0197, -, len: 413 aa. Equivalent to Rv0191, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug,similar to several hypothetical proteins e.g. YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from Escherichia coli (396 aa), FASTA scores: opt: 475, E(): 4.2e-33, (29.7% identity in 381 aa overlap); and to several chloramphenicol resistance proteins e.g. CMLR_STRLI|P31141 chloramphenicol resistance protein from stremtomyces lividans (392 aa), FASTA scores: opt: 394,E(): 6.7e-12, (28.2% identity in 383 aa overlap). Also similar to SVU09991_1 from Mycobacterium tuberculosis. Q7U2L9 No cell wall and cell processes Rv0191 NC_002945.3 Mycobrowser_v2 CDS 223799 224857 . + 0 Mb0198 conserved secreted protein Mb0198, -, len: 352 aa. Equivalent to Rv0192 and Rv0192A, len: 366 aa and 100 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 318 aa overlap and 91.1% identity in 56 aa overlap). Conserved hypothetical protein. Has Gly- Arg-rich region followed by highly Pro-rich repetitive region near N-terminus. Similar in C-terminus to other hypothetical proteins e.g. Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09 hypothetical 47.9 kd protein from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 330, E(): 3.2e-13, (35.1% identity in 271 aa overlap). Also similar to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium tuberculosis. Probable N-terminal part of Rv0192, which is member of family P5.17 with Rv0116c, Rv1433, Rv2518c,Rv0483. These are all predicted to be exported/membrane proteins. Rv0192A has typical N-terminal signal peptide which is functional and was identified by PhoA fusion screens: O52054 PGB14T-O1 PRECURSOR (FRAGMENT 45 AA) (see citation below). Since Rv0192 misses a signal peptide this suggests that there is a frameshift in the region of the overlap with Rv0192 but none found on reinspection of sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Q7U2L8 No conserved hypotheticals Rv0192 NC_002945.3 Mycobrowser_v2 CDS 224917 226764 . - 0 Mb0199c HYPOTHETICAL PROTEIN Mb0199c, -, len: 615 aa. Equivalent to Rv0193c,len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 615 aa overlap). Hypothetical unknown protein. Q7U2L7 No conserved hypotheticals Rv0193c NC_002945.3 Mycobrowser_v2 CDS 227071 230655 . + 0 Mb0200 probable transmembrane multidrug efflux pump Mb0200, -, len: 1194 aa. Equivalent to Rv0194, len: 1194 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 1194 aa overlap). Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), highly similar to many e.g. U62129|STU62129_2|T30293 ABC transport protein homolog from Salmonella typhi (1218 aa), FASTA scores: opt: 1116, E(): 0, (36.3% identity in 1209 aa overlap); CAB66302.1|AL136519 ABC transporter protein ATP-binding component from Streptomyces coelicolor (1243 aa); I84547 mdl protein from Escherichia coli (1143 aa); etc. Also similar to MTCY50_9 and MTCY50_10 from Mycobacterium tuberculosis, FASTA score: (33.8% identity in 574 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop) and one PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Alternative start possible at 1823 but no RBS. Q7U2L6 No cell wall and cell processes Rv0194 NC_002945.3 Mycobrowser_v2 CDS 231093 231728 . + 0 Mb0201 possible two component transcriptional regulatory protein (probably luxr-family) Mb0201, -, len: 211 aa. Equivalent to Rv0195, len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Putative two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 SD). Q7U2L5 No regulatory proteins Rv0195 NC_002945.3 Mycobrowser_v2 CDS 231841 232425 . + 0 Mb0202 possible transcriptional regulatory protein Mb0202, -, len: 194 aa. Equivalent to Rv0196, len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 194 aa overlap). Putative transcriptional regulatory protein, similar to two Bacillus subtilis regulators: P42105|YXAF_BACSU HYPOTHETICAL 21.0 KD PROTEIN (191 aa), FASTA scores: opt: 323, E(): 2.1e-15, (30.9% identity in 181 aa overlap); and Z99105|BSUB0002_9 negative regulator of the lincomycin operon (188 aa), FASTA scores: opt: 255, E(): 1e-10, (25.9 identity in 185 aa overlap). Q7U2L4 No regulatory proteins Rv0196 NC_002945.3 Mycobrowser_v2 CDS 584852 585841 . - 0 Mb0504c conserved protein Mb0504c, -, len: 329 aa. Equivalent to Rv0493c,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 329 aa overlap). Conserved hypothetical protein, showing some similarity to U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa), FASTA scores: opt: 166, E(): 0.00077, (35.9% identity in 131 aa overlap). Q7U1W4 No conserved hypotheticals Rv0493c NC_002945.3 Mycobrowser_v2 CDS 232425 234671 . + 0 Mb0203 POSSIBLE OXIDOREDUCTASE Mb0203, -, len: 748 aa. Equivalent to Rv0197, len: 762 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 748 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to others e.g. 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin oxidoreductase from Pseudomonas aeruginosa strain PAO1 (769 aa); 5441785|CAB46809.1|AL096811|T36812 probable dehydrogenase from Streptomyces coelicolor (747 aa), FASTA scores: opt: 617, E(): 9.8e-30, (29.9% identity in 762 aa overlap); BAB04334.1|AP001509 assimilatory nitrate reductase (catalytic subunit) from Bacillus halodurans (743 aa); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (t-g) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Q7U2L3 No intermediary metabolism and respiration Rv0197 NC_002945.3 Mycobrowser_v2 CDS 234712 236703 . - 0 Mb0204c zmp1 probable zinc metalloprotease zmp1 Mb0204c, -, len: 663 aa. Equivalent to Rv0198c,len: 663 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 663 aa overlap). Probable zinc metalloprotease (EC 3.4.24.-), equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa),FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 aa overlap). Also similar to many other metalloproteases e.g. members of the eukaryotic neprilysin family: P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA scores: opt: 872, E(): 0, (31.1% identity in 692 aa overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): 0, (30.0% identity in 654 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY. Q7U2L2 No intermediary metabolism and respiration Rv0198c NC_002945.3 Mycobrowser_v2 CDS 236746 237405 . + 0 Mb0205 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0205, -, len: 219 aa. Equivalent to Rv0199, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Probable conserved membrane protein, equivalent to Z95398|MLCL622.13 from Mycobacterium leprae (224 aa), FASTA scores: opt: 920,E(): 0, (67.7% identity in 220 aa overlap). Also some similarity to Mce-associated membrane proteins from Mycobacterium tuberculosis e.g. Rv0178, Rv0175, etc. Q7U2L1 No cell wall and cell processes Rv0199 NC_002945.3 Mycobrowser_v2 CDS 237402 238091 . + 0 Mb0206 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0206, -, len: 229 aa. Equivalent to Rv0200, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Possible conserved transmembrane protein, equivalent to Z95398|MLCL622.14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1147, E(): 0, (74.7% identity in 229 aa overlap). Also some similarity to Rv1973 from Mycobacterium tuberculosis (160 aa); and Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA scores: opt: 134, E(): 0.063, (25.8% identity in 159 aa overlap). Q7U2L0 No cell wall and cell processes Rv0200 NC_002945.3 Mycobrowser_v2 CDS 238588 241488 . - 0 Mb0208c mmpL11 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11 Mb0208c, mmpL11, len: 966 aa. Equivalent to Rv0202c, len: 966 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 966 aa overlap). Probable mmpL11, conserved transmembrane transport protein (see citation below), equivalent to Z95398|MLCL622.16c from Mycobacterium leprae (1014 aa), FASTA scores: opt: 4076, E(): 0, (72.8% identity in 1017 aa overlap). Member of RND superfamily, similar to several putative transport proteins e.g. P96687 from Bacillus subtilis (724 aa),FASTA scores: opt: 594, E(): 9.1e-29, (26.9% identity in 717 aa overlap); etc. BELONGS TO THE MMPL FAMILY. X2BED8,P65375 No cell wall and cell processes Rv0202c NC_002945.3 Mycobrowser_v2 CDS 243580 244683 . + 0 Mb0211 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0211, -, len: 367 aa. Equivalent to Rv0205, len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 367 aa overlap). Possible conserved transmembrane protein, similar to hypothetical proteins from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces coelicolor (402 aa), FASTA scores: opt: 436, E(): 1.7e-21,(27.2% identity in 349 aa overlap); Z99117|BSUB0014_221 from Bacillus subtilis (353 aa), FASTA scores: opt: 394,E(): 8.6e-19, (28.7% identity in 324 aa overlap). Q7U2K6 No cell wall and cell processes Rv0205 NC_002945.3 Mycobrowser_v2 CDS 244680 247514 . - 0 Mb0212c mmpL3 POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL3 Mb0212c, mmpL3, len: 944 aa. Equivalent to Rv0206c,len: 944 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 944 aa overlap). Possible mmpL3,conserved transmembrane transport protein (see first citation below), equivalent to Z95398|MLCL622.18c from Mycobacterium leprae (955 aa), FASTA scores: opt: 806,E(): 1.8e-21, (57.2% identity in 243 aa overlap). Member of RND superfamily, similar to others. BELONGS TO THE MMPL FAMILY. TBparse score is 0.928. Q7U2K5 No NC_002945.3 Mycobrowser_v2 CDS 247580 248308 . - 0 Mb0213c CONSERVED HYPOTHETICAL PROTEIN Mb0213c, -, len: 242 aa. Equivalent to Rv0207c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). Q7U2K4 No conserved hypotheticals Rv0207c NC_002945.3 Mycobrowser_v2 CDS 248311 249102 . - 0 Mb0214c HYPOTHETICAL METHLYTRANSFERASE (METHYLASE) Mb0214c, -, len: 263 aa. Equivalent to Rv0208c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 263 aa overlap). Hypothetical methyltransferase (EC 2.1.1.-), equivalent to Z95398|MLCL622_20 from Mycobacterium leprae (279 aa),FASTA score: (64.2% identity in 246 aa overlaps). Also similar to others e.g. 10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c HYPOTHETICAL METHLYTRANSFERASE from Streptomyces coelicolor (271 aa). Could start at aa 7. X2BE98,P67499 No intermediary metabolism and respiration Rv0208c NC_002945.3 Mycobrowser_v2 CDS 251978 253798 . + 0 Mb0217 pckA probable iron-regulated phosphoenolpyruvate carboxykinase [gtp] pcka (phosphoenolpyruvate carboxylase) (pepck)(pep carboxykinase) Mb0217, pckA, len: 606 aa. Equivalent to Rv0211,len: 606 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 606 aa overlap). Probable pckA (alternate gene names: pckG and pck1), phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32), equivalent to Z95398|MLCL622_21 PROBABLE PHOSPHOENOLPYRUVATE CARBOXYKINASE from Mycobacterium leprae (609 aa), FASTA score: (86.1% identity in 605 aa overlap). Also highly similar to others e.g. PPCK_NEOFR|P22130 phosphoenolpyruvate carboxykinase [GTP] (608 aa), FASTA scores: opt: 2287, E(): 0, (55.9% identity in 598 aa overlap). Contains PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. BELONGS TO THE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] FAMILY. X2BEE3,P65687 No intermediary metabolism and respiration Rv0211 NC_002945.3 Mycobrowser_v2 CDS 623271 623432 . - 0 Mb0543A Conserved protein Mb0543A, len: 53 aa. Equivalent to Rv0530A len: 53 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 53 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BFB5 No conserved hypotheticals Rv0530A NC_002945.3 Mycobrowser_v2 CDS 253865 254836 . - 0 Mb0218c nadR POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN NADR (PROBABLY ASNC-FAMILY) Mb0218c, nadR, len: 323 aa. Equivalent to Rv0212c,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Possible nadR (alternate gene name: nadI), transcriptional regulator,similar to others e.g. NADR_ECOLI|P27278 transcriptional regulator from Escherichia coli (410 aa), FASTA scores: opt: 377, E (): 1e-17, (31.1% identity in 347 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2K1 No NC_002945.3 Mycobrowser_v2 CDS 384632 385516 . + 0 Mb0323 POSSIBLE BETA-1,3-GLUCANASE PRECURSOR Mb0323, -, len: 294 aa. Equivalent to Rv0315, len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 294 aa overlap). Possible beta-1,3-glucanase precursor (EC 3.2.1.-) (has hydrophobic stretch in its N-terminal part), similar to others e.g. Q51333|AAC44371.1 BETA-1,3-GLUCANASE II A from Oerskovia xanthineolytica (306 aa), FASTA scores: opt: 76, E(): 3e-14, (34.1% identity in 302 aa overlap); and AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia xanthineolytica (435 aa). Contains glycosyl hydrolases family 16 active site signature (PS01034). Q7U2A2 No intermediary metabolism and respiration Rv0315 NC_002945.3 Mycobrowser_v2 CDS 254833 256146 . - 0 Mb0219c POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb0219c, -, len: 437 aa. Equivalent to Rv0213c,len: 437 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 437 aa overlap). Possible methyltransferase (EC 2.1.1.-), weakly similar to others methyltransferases e.g. AF127374_30|LINA from Streptomyces lavendulae (611 aa), FASTA scores: opt: 400, E(): 8.1e-19,(27.3% identity in 388 aa overlap); Q50258 fortimicin kl1 methyltransferase (553 aa), FASTA scores: opt: 267, E(): 1.2e-13, (29.3% identity in 351 aa overlap). Q7U2K0 No intermediary metabolism and respiration Rv0213c NC_002945.3 Mycobrowser_v2 CDS 263037 264248 . + 0 Mb0226 lipC PROBABLE ESTERASE LIPC Mb0226, lipC, len: 403 aa. Equivalent to Rv0220,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 403 aa overlap). Probable esterase (EC 3.1.1.-), similar to others proteins and esterases from various organisms and Mycobacterium tuberculosis e.g. Q50681 (431 aa), FASTA scores: opt: 841, E(): 0, (38.2% identity in 408 aa overlap); Rv1426c, Rv1399c, etc. Contains PS00122 Carboxylesterases type-B serine active site. Q7U2J3 No intermediary metabolism and respiration Rv0220 NC_002945.3 Mycobrowser_v2 CDS 285510 286676 . + 0 Mb0243 lpqI PROBABLE CONSERVED LIPOPROTEIN LPQI Mb0243, lpqI, len: 388 aa. Equivalent to Rv0237,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 388 aa overlap). Probable lpQI,conserved lipoprotein, equivalent to AL022486|MLCB1883_8|T44873 probable secreted hydrolase from Mycobacterium leprae (387 aa), FASTA scores: opt: 1831, E(): 0, (73.3% identity in 390 aa overlap). Also similar to other lipoproteins and various hydrolases e.g. P40406|2126897|YBBD_BACSU|I39839 HYPOTHETICAL 70.6 KDA LIPOPROTEIN from Bacillus subtilis (642 aa); P48823|HEXA_ALTSO BETA-HEXOSAMINIDASE A PRECURSOR from ALTEROMONAS SP. (598 aa), FASTA scores: opt: 415, E(): 5.8e-17, (31.2% identity in 343 aa overlap); PCC6803|P74340 BETA-GLUCOSIDASE from Synechocystis sp. (538 aa), FASTA scores: opt: 414, E(): 6.1e-17, (30.6 identity in 320 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U2H7 No cell wall and cell processes Rv0237 NC_002945.3 Mycobrowser_v2 CDS 256260 257873 . + 0 Mb0220 fadD4 PROBABLE FATTY-ACID-COA LIGASE FADD4 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0220, fadD4, len: 537 aa. Equivalent to Rv0214,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 537 aa overlap). Probable fadD4,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. 4CL_PINTA|P41636 4-coumarate--coa ligase (EC 6.2.1.12) (537 aa), FASTA scores: opt: 622, E(): 1e-31,(30.0% identity in 514 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY6A4.14 FASTA score: (30.7% identity in 501 aa overlap); MTCY493_27,MTCY07A7_11, MTCI28_6. Contains PS00455 putative AMP-binding domain signature. Q7U2J9 No NC_002945.3 Mycobrowser_v2 CDS 257915 259081 . - 0 Mb0221c fadE3 PROBABLE ACYL-COA DEHYDROGENASE FADE3 Mb0221c, fadE3, len: 388 aa. Equivalent to Rv0215c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Probable fadE3,acyl-dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis (EC 1.3.99.-) (379 aa), FASTA scores: opt: 812, E(): 0,(39.5% identity in 354 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Q7U2J8 No NC_002945.3 Mycobrowser_v2 CDS 259138 260151 . + 0 Mb0222 double hotdog hydratase Mb0222, -, len: 337 aa. Equivalent to Rv0216, len: 337 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 337 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622_22 from Mycobacterium leprae (339 aa), FASTA scores: E(): 0, (73.7 identity in 338 aa overlap). Q7U2J7 No intermediary metabolism and respiration Rv0216 NC_002945.3 Mycobrowser_v2 CDS 260148 261056 . - 0 Mb0223c lipW POSSIBLE ESTERASE LIPW Mb0223c, lipW, len: 302 aa. Equivalent to Rv0217c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Possible esterase (EC 3.1.1.-), showing similarity with others e.g. EST_ACICA|P18773 esterase (303 aa), FASTA scores: opt: 320, E(): 3.2e-13, (29.2% identity in 274 aa overlap). Q7U2J6 No NC_002945.3 Mycobrowser_v2 CDS 261149 262477 . + 0 Mb0224 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0224, -, len: 442 aa. Equivalent to Rv0218, len: 442 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 442 aa overlap). Probable conserved transmembrane protein, some similarity with sulfite oxidases (EC 1.8.3.1) e.g. SUOX_HUMAN|P51687 sulfite oxidase precursor (488 aa), FASTA scores: opt: 153, E(): 0.0087, (28.6% identity in 161 aa overlap); and with some nitrate reductases (EC 1.6.6.3) e.g. NIA_FUSOX|P39863 nitrate reductase (NADPH) (905 aa), FASTA scores: opt: 143, E(): 0.06, (29.3% identity in 92 aa overlap). Also similar to BSUB0017_86 from Mycobacterium tuberculosis. Q7U2J5 No cell wall and cell processes Rv0218 NC_002945.3 Mycobrowser_v2 CDS 264292 265065 . + 0 Mb0227 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb0227, -, len: 257 aa. Equivalent to 5' end of Rv0221, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 234 aa overlap). Conserved hypothetical protein, similar to others proteins from Mycobacterium tuberculosis e.g. Q50680|Rv2285|MT2343|MTCY339.25c hypothetical 47.7 kDa protein (445 aa), FASTA scores: opt: 455, E(): 8.1e-23,(26.7% identity in 461 aa overlap); Rv3740c, Rv3734c, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein,echA1 (Rv0222). Q7U2J2 No NC_002945.3 Mycobrowser_v2 CDS 264931 266088 . - 0 Mb0228c PROBABLE ALDEHYDE DEHYDROGENASE Mb0228c, -, len: 385 aa. Equivalent to Rv0223c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(95.3% identity in 364 aa overlap). Probable aldehyde dehydrogenase (EC 1.2.1.-), similar to others e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde dehydrogenase from Deinococcus radiodurans strain R1 (495 aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent from Gluconobacter oxydans (498 aa), FASTA scores: opt: 1157, E (): 0, (42.1% identity in 482 aa overlap); etc. Also similar to Rv0768, Rv2858c, etc from Mycobacterium tuberculosis. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site; and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to a shorter product,with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 487 aa). Q7U2J1 No intermediary metabolism and respiration Rv0223c NC_002945.3 Mycobrowser_v2 CDS 266187 266951 . - 0 Mb0229c POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb0229c, -, len: 254 aa. Equivalent to Rv0224c,len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 254 aa overlap). Possible methyltransferase (EC 2.1.1.-), showing weak similarity with other methyltransferases e.g. P74388 STEROL-C-METHYLTRANSFERASE (318 aa), FASTA scores: opt: 190, E(): 3.6e-05, (33.3% identity in 114 aa overlap). Equivalent to AL022486|MLCB1883_1 from Mycobacterium leprae (269 aa), FASTA scores: opt: 1456, E(): 0, (82.9% identity in 252 aa overlap). Also some similarity with MTCY21B4.22c from Mycobacterium tuberculosis FASTA score: (30.1% identity in 136 aa overlap). X2BEA5,Q7U2J0 No intermediary metabolism and respiration Rv0224c NC_002945.3 Mycobrowser_v2 CDS 266987 268141 . + 0 Mb0230 POSSIBLE CONSERVED PROTEIN Mb0230, -, len: 384 aa. Equivalent to Rv0225, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 384 aa overlap). Possible conserved protein involved in LPS biosynthesis, similar to O26275 LPS BIOSYNTHESIS RFBU RELATED PROTEIN (382 aa), FASTA scores: opt: 426, E(): 1.2e-20, (28.2% identity in 394 aa overlap). Some similarity with Rv3032 from Mycobacterium tuberculosis FASTA score: (31.6% identity in 228 aa overlap). Q7U2I9 No cell wall and cell processes Rv0225 NC_002945.3 Mycobrowser_v2 CDS 321089 321598 . - 0 Mb0274c HYPOTHETICAL PROTEIN Mb0274c, -, len: 169 aa. Equivalent to Rv0268c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Hypothetical unknown protein. Q7U2E8 No conserved hypotheticals Rv0268c NC_002945.3 Mycobrowser_v2 CDS 268158 269888 . - 0 Mb0231c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0231c, -, len: 576 aa. Equivalent to Rv0226c,len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 576 aa overlap). Probable conserved transmembrane protein, equivalent, except in N-terminal part, to AC32114.1|AL583926 conserved membrane protein from Mycobacterium leprae (600 aa), FASTA scores: opt: 2086, E(): 0, (70.3% identity in 579 aa overlap). Also similar to AL021411|SC7H1_20 from Streptomyces coelicolor (483 aa), FASTA scores: opt: 180, E(): 0.00028, (26.5 identity in 388 aa overlap). Q7U2I8 No cell wall and cell processes Rv0226c NC_002945.3 Mycobrowser_v2 CDS 269898 271163 . - 0 Mb0232c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0232c, -, len: 421 aa. Equivalent to Rv0227c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 421 aa overlap). Possible conserved membrane protein, equivalent to AL022486|MLCB1883_4 from Mycobacterium leprae (448 aa), FASTA scores: opt: 2148,E(): 0, (76.6% identity in 423 aa overlap). Q7U2I7 No cell wall and cell processes Rv0227c NC_002945.3 Mycobrowser_v2 CDS 286752 287366 . + 0 Mb0244 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb0244, -, len: 204 aa. Equivalent to Rv0238, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible transcriptional regulatory protein, TetR family,equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative tetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266, E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa). Q7U2H6 No regulatory proteins Rv0238 NC_002945.3 Mycobrowser_v2 CDS 271379 272602 . + 0 Mb0233 PROBABLE INTEGRAL MEMBRANE ACYLTRANSFERASE Mb0233, -, len: 407 aa. Equivalent to Rv0228, len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Probable integral membrane acyltransferase (EC 2.3.1.-), equivalent to 3063875|CAA18555.1|AL022486|T44870 ACYLTRANSFERASE from Mycobacterium leprae (384 aa), FASTA scores: opt: 2004,E(): 0, (79.3% identity in 381 aa overlap). Also similar to others e.g. Q11064 PROBABLE ACYLTRANSFERASE CY50.28C (383 aa), FASTA scores: opt: 372, E(): 2.6e-16, (35.9% identity in 359 aa overlap); Q00718|MDMB_STRMY ACYLTRANSFERASE. Very similar to Rv0111, Rv1254, etc from Mycobacterium tuberculosis. Q7U2I6 No intermediary metabolism and respiration Rv0228 NC_002945.3 Mycobrowser_v2 CDS 287428 287661 . + 0 Mb0245 vapb24 possible antitoxin vapb24 Mb0245, -, len: 77 aa. Equivalent to Rv0239, len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Conserved hypothetical protein, weakly similar to Rv1839c|Z83859|MTCY359_34 from Mycobacterium tuberculosis (87 aa), FASTA scores: opt: 88,E(): 5, (40.0% identity in 45 aa overlap). Q7U2H5 No virulence, detoxification, adaptation Rv0239 NC_002945.3 Mycobrowser_v2 CDS 272630 273310 . - 0 Mb0234c possible conserved membrane protein with pin domain Mb0234c, -, len: 226 aa. Equivalent to Rv0229c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Possible conserved membrane protein, similar to several proteins from Mycobacterium tuberculosis. Other possible start sites and could be shorter as C-terminal region has some similarity with Rv2757c|D70880 from Mycobacterium tuberculosis (138 aa), FASTA scores: E(): 1e-15, (45.3% identity in 137 aa overlap), and Rv0301, Rv2546, etc. Also some similarity with Q48177 virulence associated protein C (132 aa), FASTA scores: opt: 101, E(): 0.6, (24.3% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7U2I5 No cell wall and cell processes Rv0229c NC_002945.3 Mycobrowser_v2 CDS 273307 274287 . - 0 Mb0235c php PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE) (ARYLDIALKYLPHOSPHATASE) (PARAOXONASE) (A-ESTERASE) (ARYLTRIPHOSPHATASE) (PARAOXON HYDROLASE) Mb0235c, php, len: 326 aa. Equivalent to Rv0230c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 326 aa overlap). Probable php,phosphotriesterase (EC 3.1.8.1), similar to others e.g. AAK42653.1|AE006849 putative aryldialkylphosphatase (phosphotriesterase) (paraoxonase) from Sulfolobus solfataricus (314 aa); PHP_ECOLI|P45548 PHOSPHOTRIESTERASE HOMOLOGY PROTEIN from Escherichia coli (292 aa), FASTA scores: opt: 408, E(): 7.1e-20, (31.1% identity in 305 aa overlap ); OPD_FLASP|P16648 parathion hydrolase precursor (365 aa), FASTA scores: opt: 319, E(): 5.1e-14, (34.5% identity in 333 aa overlap); etc. BELONGS TO THE PHOSPHOTRIESTERASE FAMILY. COFACTOR: CONTAINS 2 MOLES OF ZINC PER SUBUNIT. Q7U2I4 No NC_002945.3 Mycobrowser_v2 CDS 274382 276088 . + 0 Mb0236 fadE4 PROBABLE ACYL-COA DEHYDROGENASE FADE4 Mb0236, fadE4, len: 568 aa. Equivalent to Rv0231,len: 568 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 568 aa overlap). Probable fadE4,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. O29752 ACYL-COA DEHYDROGENASE (ACD-3) from Archaeoglobus fulgidus (576 aa), FASTA scores: opt: 1788, E(): 0, (51.0% identity in 577 aa overlap); ACDB_BACSU|P45857 acyl-coa dehydrogenase from Bacillus subtilis (379 aa), FASTA scores: opt: 232, E(): 2.2e- 08, (21.6% identity in 291 aa overlap). Q7U2I3 No NC_002945.3 Mycobrowser_v2 CDS 380202 381431 . + 0 Mb0319 unknown protein Mb0319, -, len: 409 aa. Equivalent to Rv0311, len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Hypothetical unknown protein. Contains PS00881 Protein splicing signature. Q7U2A6 No conserved hypotheticals Rv0311 NC_002945.3 Mycobrowser_v2 CDS 276223 276912 . + 0 Mb0237 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY) Mb0237, -, len: 229 aa. Equivalent to Rv0232, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Probable transcriptional regulatory protein, tetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149, E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, tetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U2I2 No regulatory proteins Rv0232 NC_002945.3 Mycobrowser_v2 CDS 276909 277853 . + 0 Mb0238 nrdB ribonucleoside-diphosphate reductase (beta chain) nrdb (ribonucleotide reductase small chain) Mb0238, nrdB, len: 314 aa. Equivalent to Rv0233,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 314 aa overlap). Probable nrdB (alternate gene name: rnrS) ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1), similar to others e.g. RIR2_SCHPO|P36603 ribonucleoside-diphosphate reductase (391 aa), FASTA scores: opt: 168, E(): 0.00018,(26.1% identity in 199 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. COFACTOR: BINDS 2 IRON IONS. X2BEH1,Q7U2I1 No information pathways Rv0233 NC_002945.3 Mycobrowser_v2 CDS 277929 279464 . - 0 Mb0239c gabD1 succinate-semialdehyde dehydrogenase [nadp+] dependent (ssdh) gabd1 Mb0239c, gabD1, len: 511 aa. Equivalent to Rv0234c,len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable gabD1,succinate-semialdehyde dehydrogenase [NADP+] dependent (EC 1.2.1.16), equivalent to AL022486|MLCB1883_6 PROBABLE ALDEHYDE DEHYDROGENASE from Mycobacterium leprae (457 aa),FASTA scores: opt: 2617, E(): 0, (85.7% identity in 455 aa overlap). Also highly similar to Q55585|GABD|SLR0370 PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE from Synechocystis sp. strain PCC 6803 (454 aa), FASTA scores: opt: 1676, E(): 0, (55.8% identity in 455 aa overlap); and similar to others e.g. GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from Escherichia coli (482 aa), FASTA scores: opt: 929, E(): 0, (36.5% identity in 452 aa overlap); etc. Note that similar to other cytosolic aldehyde dehydrogenases with EC number: 1.2.1.3. Also similar to Rv0768|aldA semialdehyde dehydrogenase from Mycobacterium tuberculosis (489 aa); and gabD2|Rv1731|MTCY04C12.16 POSSIBLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDANT from Mycobacterium tuberculosis (518 aa). Contains PS00070 aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Could start at different site by homology. Note that previously known as gabD2. X2BEB3,Q7U2I0 No NC_002945.3 Mycobrowser_v2 CDS 279490 280938 . - 0 Mb0240c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0240c, -, len: 482 aa. Equivalent to Rv0235c,len: 482 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 482 aa overlap). Possible conserved transmembrane protein, highly similar to AL133278|CAB61913.1|SCM11_2 putative integral membrane protein from Streptomyces coelicolor (470 aa), FASTA scores: opt: 2116, E(): 0, (61.8% identity in 474 aa overlap); and similar to hypothetical proteins from other organisms e.g. Q13392|384D8_7 hypothetical protein (579 aa), FASTA scores: opt: 355, E(): 6.9e-17, (28.5% identity in 569 aa overlap). Q7U2H9 No cell wall and cell processes Rv0235c NC_002945.3 Mycobrowser_v2 CDS 280973 285175 . - 0 Mb0241c aftd possible arabinofuranosyltransferase aftd Mb0241c, -, len: 1400 aa. Equivalent to Rv0236c,len: 1400 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1400 aa overlap). Probable conserved transmembrane protein, equivalent to AL022486|CAC32102.1|MLCB1883_7 possible integral membrane protein from Mycobacterium leprae (1440 aa), FASTA scores: opt: 7491, E(): 0, (78.8% identity in 1397 aa overlap). Q7U2H8 No cell wall and cell processes Rv0236c NC_002945.3 Mycobrowser_v2 CDS 285222 285395 . - 0 Mb0242c SMALL SECRETED PROTEIN Mb0242c, -, len: 57 aa. Equivalent to Rv0236A, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Small secreted protein. X2BEG4 No cell wall and cell processes Rv0236A NC_002945.3 Mycobrowser_v2 CDS 704489 704734 . + 0 Mb0624 vapb28 possible antitoxin vapb28 Mb0624, -, len: 81 aa. Equivalent to Rv0608, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical short proteins e.g. Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores: opt: 159, E(): 1.2e-09, (43.0% identity in 86 aa overlap); Rv2760c (89 aa); Rv1740 (70 aa), etc. Q7U1M8 No virulence, detoxification, adaptation Rv0608 NC_002945.3 Mycobrowser_v2 CDS 288136 288978 . - 0 Mb0247c htdx probable 3-hydroxyacyl-thioester dehydratase htdx Mb0247c, -, len: 280 aa. Equivalent to Rv0241c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical protein from Mycobacterium leprae (280 aa), FASTA scores: opt: 1564, E(): 0, (81.8% identity in 280 aa overlap); and CAC32097.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (300 aa). Also similar to proteins from other organisms e.g. CAB77291.1|AL160312 putative dehydratase from Streptomyces coelicolor (291 aa); part of BAA92930.1|AB032743 fatty acid synthetase beta subunit from Pichia angusta (2060 aa). Q7U2H3 No intermediary metabolism and respiration Rv0241c NC_002945.3 Mycobrowser_v2 CDS 288989 290353 . - 0 Mb0248c fabG4 PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG4 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) Mb0248c, fabG4, len: 454 aa. Equivalent to Rv0242c,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 454 aa overlap). Probable fabG4,3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100),equivalent to 3063883|CAA18568.1|AL022486|MLCB1883_13|T44878 3-oxoacyl-[acyl-carrier protein] reductase homolog from Mycobacterium leprae (454 aa), FASTA scores: opt: 2486,E(): 0, (84.8% identity in 454 aa overlap). C-terminal part highly similar to many FabG proteins e.g. U39441|VHU3944 1_2 from Vibrio harveyi (244 aa), FASTA scores: opt: 562, E(): 3.4e-28, (40.2% identity in 241 aa overlap); U91631|PAU91631_3 from Pseudomonas aeruginosa (247 aa), FASTA scores: opt: 584, E(): 1.5e-29, (44.4% identity in 241 aa overlap). Has N-terminal extension of ~200 aa and C-terminal part contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U2H2 No NC_002945.3 Mycobrowser_v2 CDS 328747 329328 . + 0 Mb0280 conserved protein Mb0280, -, len: 193 aa. Equivalent to Rv0274, len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 193 aa overlap). Conserved hypothetical protein, highly similar to AAK25058.1|AE005973 conserved hypothetical protein from Caulobacter crescentus (174 aa). Shows also some similarity to others hypothetical proteins e.g. AJ002571|BSAJ2571_7 from Bacillus subtilis (316 aa), FASTA scores: opt: 138, E(): 0.033, (27.1% identity in 133 aa overlap). Previous hits with Q56415|M85195 FOSFOMYCIN-RESISTANCE PROTEIN from SERRATIA MARCESCENS (141 aa), FASTA scores: opt: 82, E(): 1.1e -08, (29.1% identity in 151 aa overlap). Contains PS00082 Extradiol ring-cleavage dioxygenases signature near C-terminus. TBparse score is 0.914. Q7U2E2 No conserved hypotheticals Rv0274 NC_002945.3 Mycobrowser_v2 CDS 290495 291817 . + 0 Mb0249 fadA2 PROBABLE ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE) Mb0249, fadA2, len: 440 aa. Equivalent to Rv0243,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable fadA2,acetyl-CoA acyltransferase (3-acyl-CoA thiolase) (EC 2.3.1.16), equivalent, but shorter 17 aa, to AL022486|MLCB1883_14T44879 acetyltransferase from Mycobacterium leprae (457 aa), FASTA scores: opt: 250 7,E(): 0, (87.6% identity in 435 aa overlap). Also highly similar to many e.g. G83046|PA478 probable acyl-CoA thiolase from Pseudomonas aeruginosa (425 aa); AB77293.1|AL160312 putative ketoacyl CoA thiolase from Streptomyces coelicolor (428 aa); P76503|7449731|YFCY_ECOLI|D65007|B2342 PROBABLE 3-KETOACYL-COA THIOLASE (ACETYL-COA ACYLTRANSFERASE) (BETA-KETOTHIOLASE) from Escherichia coli strain K-12 (436 aa), FASTA scores: opt: 914, E(): 0, (38.2% identity in 434 aa overlap); P55084|ECHB_HUMAN MITOCHONDRIAL TRIFUNCTONAL ENZYME (474 aa), FASTA scores: opt: 881, E(): 0, (37.7 identity in 451 aa overlap). Contains PS00099 Thiolases active site. BELONGS TO THE THIOLASE FAMILY. Q7U2H1 No NC_002945.3 Mycobrowser_v2 CDS 292123 293958 . - 0 Mb0250c fadE5 PROBABLE ACYL-COA DEHYDROGENASE FADE5 Mb0250c, fadE5, len: 611 aa. Equivalent to Rv0244c,len: 611 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 611 aa overlap). Probable fadE5,acyl-CoA dehydrogenase (EC 1.3.99.-), equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa),FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa overlap). Also highly similar to AL0211|MTV007.14 from Mycobacterium tuberculosis (609 aa), FASTA scores: opt: 2576, E(): 0, (64.6% identity in 611 aa overlap); and to various other bacterial proteins described as putative acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229,E(): 6.8e-08, (29.8% identity in 409 aa overlap); etc. Q7U2H0 No NC_002945.3 Mycobrowser_v2 CDS 385565 386179 . + 0 Mb0324 POSSIBLE MUCONOLACTONE ISOMERASE Mb0324, -, len: 204 aa. Equivalent to Rv0316, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible muconolactone isomerase (EC 5.3.3.-), showing weak similarity with some muconolactone isomerases e.g. O33947|CTC1_ACILW MUCONOLACTONE DELTA-ISOMERASE 1 (MIASE 1)(96 aa), FASTA scores: opt: 179, E(): 3.9e-05, (32.6% identity in 92 aa overlap). Q7U2A1 No intermediary metabolism and respiration Rv0316 NC_002945.3 Mycobrowser_v2 CDS 294330 294818 . + 0 Mb0251 possible oxidoreductase Mb0251, -, len: 162 aa. Equivalent to Rv0245, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to AL022486|MLCB1883_17|T44882 probable oxidoreductase from Mycobacterium leprae (162 aa), FASTA scores: opt: 860,E(): 0, (83.4% identity in 157 aa overlap). Also similar to several hypothetical proteins and various oxidoreductases e.g. AAK24246.1|AE005898 NADH:riboflavin 5'-phosphate oxidoreductase from Caulobacter crescentus (174 aa); Q02058|DIM6_STRCO|CAA45048.1 ACTINORHODIN POLYKETIDE DIMERASE from STREPTOMYCES COELICOLOR (177 aa),FASTA scores: opt: 308, E(): 3. 2e-15, (37.8% identity in 143 aa overlap). Also similar to Z84498|Rv1939|MTCY09F9.25c from Mycobacterium tuberculosis (171 aa), FASTA scores: opt: 517, E(): 3.5e-30, (49.4% identity in 158 aa overlap). Q7U2G9 No intermediary metabolism and respiration Rv0245 NC_002945.3 Mycobrowser_v2 CDS 295134 296444 . + 0 Mb0252 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0252, -, len: 436 aa. Equivalent to Rv0246, len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 436 aa overlap). Probable conserved integral membrane protein, similar to Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 712, E(): 0, (33.2% identity in 422 aa overlap). Q7U2G8 No cell wall and cell processes Rv0246 NC_002945.3 Mycobrowser_v2 CDS 296441 297187 . - 0 Mb0253c PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE) Mb0253c, -, len: 248 aa. Equivalent to Rv0247c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Probable succinate dehydrogenase, iron-sulfur subunit (EC 1.3.99.1), highly similar to CAC44313.1|AL596043 putative succinate dehydrogenase iron-sulfur subunit from Streptomyces coelicolor (259 aa); and similar to iron-sulphur protein subunits of fumarate reductase or succinate dehydrogenases from many bacteria e.g. NP_147618.1|7521083|B72691 fumarate reductase iron-sulfur protein from Aeropyrum pernix (305 aa); NP_069516.1|2649932|AAB90556.1|AE001057 succinate dehydrogenase iron-sulfur subunit B (sdhB) from Archaeoglobus fulgidus (236 aa); etc. Also similar to Q10761|FRDB_MYCTU|7431693|F70762 FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 358, E():1e-16, (31.3% identity in 214 aa overlap). Contains PS00197 2Fe-2S ferredoxins,iron-sulfur binding region signature. NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?). Q7U2G7 No intermediary metabolism and respiration Rv0247c NC_002945.3 Mycobrowser_v2 CDS 329258 329983 . - 0 Mb0281c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0281c, -, len: 241 aa. Equivalent to Rv0275c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 241 aa overlap). Putative transcriptional regulator, showing some similarity with Rv0825c from Mycobacterium tuberculosis (213 aa), FASTA scores: opt: 230, E(): 2.7e-07, (32.6% identity in 190 aa overlap). Belongs to Mycobacterium tuberculosis regulatory protein family with many TetR orthologues. Q7U2E1 No regulatory proteins Rv0275c NC_002945.3 Mycobrowser_v2 CDS 297188 299128 . - 0 Mb0254c PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE) Mb0254c, -, len: 646 aa. Equivalent to Rv0248c,len: 646 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 646 aa overlap). Probable succinate dehydrogenase, flavoprotein subunit (EC 1.3.99.1), highly similar to flavoprotein subunit of various succinate dehydrogenases e.g. M88696|RIRSDHA_1 flavoprotein from Rickettsia prowazekii (596 aa), FASTA scores: opt: 651,E(): 0, (34.6 % identity in 598 aa overlap). Also similar to truncated U00022_17 flavoprotein from Mycobacterium leprae (401 aa), FASTA scores: opt: 677, E(): 0, (39.0% identity in 423 aa overlap). NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?). Q7U2G6 No intermediary metabolism and respiration Rv0248c NC_002945.3 Mycobrowser_v2 CDS 299159 299980 . - 0 Mb0255c probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) Mb0255c, -, len: 273 aa. Equivalent to Rv0249c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Probable succinate dehydrogenase, membrane-anchor subunit for succinate dehydrogenase encoded by Rv0247c and Rv0248c. Highly similar to AC44315.1|AL596043 putative integral membrane protein from Streptomyces coelicolor (278 aa). NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?). Q7U2G5 No intermediary metabolism and respiration Rv0249c NC_002945.3 Mycobrowser_v2 CDS 300498 300977 . - 0 Mb0257c hsp HEAT SHOCK PROTEIN HSP (HEAT-STRESS-INDUCED RIBOSOME-BINDING PROTEIN A) Mb0257c, hsp, len: 159 aa. Equivalent to Rv0251c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). hsp (alternate gene name: hsp20, hrpA, acr2), heat-stress-induced ribosome-binding protein A (see citations below). Highly similar to AAD39038.1|AF072875_1|AF072875 putative HSP20 from Mycobacterium smegmatis (145 aa), FASTA scores: opt: 479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and similar to many bacterial and eukaryotic hsp proteins e.g. P12811|HS2C_CHLRE CHLOROPLAST HEAT SHOCK 22KD PROTEIN from CHLAMYDOMONAS REINHARDTII (157 aa), FASTA scores: opt: 184, E(): 1.2e-05, (32.4% identity in 142 aa overlap). Also similar to PCC6803 Spore protein sp21 from Synechocystis sp. (146 aa), FASTA scores: opt: 213, E(): 1.2e-07, (30.3 identity in 145 aa overlap). Also similar to P30223|14KD_MYCTU 14 KDA ANTIGEN (16 KDA ANTIGEN) 19K major membrane protein (HSP 16.3) from Mycobacterium tuberculosis (144 aa). BELONG TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY. Q7U2G3 No NC_002945.3 Mycobrowser_v2 CDS 328030 328650 . - 0 Mb0279c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0279c, -, len: 206 aa. Equivalent to Rv0273c,len: 206 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 206 aa overlap). Possible transcriptional regulator, showing some similarity to hypothetical regulators from Mycobacterium tuberculosis e.g. P96222|Rv3855|MTCY01A6.13c (216 aa); O08377|Rv1534|MTCY07A7A.03 (225 aa), FASTA scores: opt: 123, E(): 3.2e-06, (28.5% identity in 172 aa overlap). Q7U2E3 No regulatory proteins Rv0273c NC_002945.3 Mycobrowser_v2 CDS 314108 314740 . - 0 Mb0270c CONSERVED HYPOTHETICAL PROTEIN Mb0270c, -, len: 210 aa. Equivalent to Rv0264c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Conserved hypothetical protein, equivalent to CAC32080.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (222 aa). Also similar to others hypothetical proteins e.g. AL121596|SC51A_20 from Streptomyces coelicolor (252 aa), FASTA scores: opt: 420, E(): 2.7e-20, (41.7% identity in 204 aa overlap); P75744|YBGJ_ECOLI HYPOTHETICAL 23.9 KD PROTEIN from Escherichia coli (218 aa), FASTA scores: E(): 2.1e-14, (35.7% identity in 182 aa overlap); YH31_HAEIN|P44299|hi173 hypothetical protein from Haemophilus influenzae (213 aa), FASTA scores: opt: 252,E(): 8.3e-10, (31.1% identity in 183 aa overlap). Q7U2F2 No conserved hypotheticals Rv0264c NC_002945.3 Mycobrowser_v2 CDS 301191 303752 . + 0 Mb0258 nirB PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB Mb0258, nirB, len: 853 aa. Equivalent to Rv0252,len: 853 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 853 aa overlap). Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4), flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0,(49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA scores: opt: 2902, E(): 0, (54.2% identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. HOMODIMER WHICH ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron; Siroheme. Q7U2G2 No intermediary metabolism and respiration Rv0252 NC_002945.3 Mycobrowser_v2 CDS 303778 304134 . + 0 Mb0259 nirD PROBABLE NITRITE REDUCTASE [NAD(P)H] SMALL SUBUNIT NIRD Mb0259, nirD, len: 118 aa. Equivalent to Rv0253,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Probable nirD,nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4),similar to others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia coli strains K12 and O157:H7 (108 aa), FASTA scores: opt: 271, E():1.7e-12, (41.9% identity in 105 aa overlap). ASSOCIATES WITH NIRB|Rv0252. Q7U2G1 No intermediary metabolism and respiration Rv0253 NC_002945.3 Mycobrowser_v2 CDS 304150 304674 . - 0 Mb0260c cobU probable bifunctional cobalamin biosynthesis protein cobu: cobinamide kinase + cobinamide phosphate guanylyltransferase Mb0260c, cobU, len: 174 aa. Equivalent to Rv0254c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Probable cobU,cobalamin biosynthesis protein including a cobinamide kinase (EC 2.-.-.-) and cobinamide phosphate guanylyltransferase (EC 2.-.-.-). Highly similar to many e.g. Q05599|COBU_SALTY COBINAMIDE KINASE / COBINAMIDE PHOSPHATE GUANYLYLTRANSFERASE from Salmonella typhimurium (181 aa), FASTA scores: opt: 308, E(): 1.1e-14, (38.7% identity in 181 aa overlap); P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional cobalamin biosynthesis protein cobU from Escherichia coli strains K12 and O157:H7 (181 aa); part of AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa),FASTA scores: opt: 445, E(): 3.6e-23, (46.0% identity in 176 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2G0 No NC_002945.3 Mycobrowser_v2 CDS 1886443 1887147 . + 0 Mb1703 unknown protein Mb1703, -, len: 234 aa. Equivalent to Rv1676, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 234 aa overlap). Hypothetical unknown protein. Q7TZT4 No conserved hypotheticals Rv1676 NC_002945.3 Mycobrowser_v2 CDS 304699 306183 . - 0 Mb0261c cobQ1 probable cobyric acid synthase cobq1 Mb0261c, cobQ1, len: 494 aa. Equivalent to Rv0255c,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 494 aa overlap). Probable cobQ1,cobyric acid synthase, similar to many e.g. Z46611|RCBLUGNS_8 COBYRIC ACID SYNTHASE from R.capsulatus (483 aa), FASTA scores: opt: 1239, E(): 0, (47.1% identity in 493 aa overlap); P29932|COBQ_PSEDE COBYRIC ACID SYNTHASE from Pseudomonas denitrificans (484 aa), FASTA scores: opt: 1168, E():0, (44.9% identity in 490 aa overlap); etc. BELONGS TO THE COBB/COBQ FAMILY, COBQ SUBFAMILY. Note that previously known as cobQ. X2BEI1,P0A533 No NC_002945.3 Mycobrowser_v2 CDS 306202 307872 . - 0 Mb0262c PPE2 ppe family protein ppe2 Mb0262c, PPE2, len: 556 aa. Equivalent to Rv0256c,len: 556 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 556 aa overlap). Member of the M. tuberculosis PPE family, similar to many e.g. Rv0280,Rv0286, etc. Equivalent to Z98756|MLCB2492.30 from Mycobacterium leprae (572 aa), FASTA scores: opt: 1837,E(): 0, (62.9% identity in 461 aa overlap). Q7U2F9 No NC_002945.3 Mycobrowser_v2 CDS 309839 310984 . - 0 Mb0266c possible transcriptional regulatory protein Mb0266c, -, len: 381 aa. Equivalent to Rv0260c,len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 381 aa overlap). Possible two-component response regulator, highly similar to CAB72204.1|AL138851 putative transcriptional regulator from Streptomyces coelicolor (395 aa); and similar to O34394|D69851|YJJA conserved hypothetical protein from Bacillus subtilis (270 aa), FASTA scores: opt: 312, E(): 7.4e-14, (25.8% identity in 267 aa overlap). Also some similarity to regulatory proteins at C-terminal region e.g. CUTR_STRLI|Q03756 transcriptional regulatory protein (217 aa), FASTA scores: opt: 138, E(): 0.02, (30.6% identity in 111 aa overlap). Q7U2F5 No regulatory proteins Rv0260c NC_002945.3 Mycobrowser_v2 CDS 886262 886990 . - 0 Mb0814c HYPOTHETICAL PROTEIN Mb0814c, -, len: 242 aa. Equivalent to Rv0790c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Hypothetical unknown protein. Q7U197 No conserved hypotheticals Rv0790c NC_002945.3 Mycobrowser_v2 CDS 311084 312493 . - 0 Mb0267c narK3 PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION PROTEIN NARK3 (NITRITE FACILITATOR) Mb0267c, narK3, len: 469 aa. Equivalent to Rv0261c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable nirK3,nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),equivalent to AAB41700.1|U72744 nitrite extrusion protein from Mycobacterium fortuitum (471 aa); and 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein homolog from Mycobacterium leprae (517 aa; longer in N-terminus). Also similar to other nitrite extrusion proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 755, E(): 0, (35.0% identity in 466 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS. Q7U2F4 No NC_002945.3 Mycobrowser_v2 CDS 312634 313179 . - 0 Mb0268c aac AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE AAC (AAC(2')-IC) Mb0268c, aac, len: 181 aa. Equivalent to Rv0262c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). aac, aminoglycoside 2'-N-acetyltransferase (aac(2')-IC) (EC 2.3.1.-) (see citation below), highly similar to NP_302635.1|NC_002677 aminoglycoside 2'-N-acetyltransferase from Mycobacterium leprae (182 aa); Q49157|AAC2_MYCFO|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium fortuitum (195 aa), FASTA scores: opt: 884, E(): 0, (69.1% identity in 181 aa overlap); and P94968|AAC2_MYCSM|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium smegmatis (210 aa) (see also citation below). Also similar to Q52424|AAC2_PROST AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE from Providencia stuartii (178 aa). BELONGS TO THE AAC(2')-I FAMILY OF ACETYLTRANSFERASES. Note that previously known as aac(2')-IC. X2BEJ5,P0A5N1 No NC_002945.3 Mycobrowser_v2 CDS 313189 314091 . - 0 Mb0269c CONSERVED HYPOTHETICAL PROTEIN Mb0269c, -, len: 300 aa. Equivalent to Rv0263c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Conserved hypothetical protein, equivalent to NP_302634.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (305 aa). Also similar to others e.g. AL121596|SC51A_21 hypothetical protein from Streptomyces coelicolor (285 aa), FASTA scores: opt: 714, E(): 0, (45.3% identity in 289 aa overlap); NP_233164.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (309 aa); NP_406216.1|NC_003143 conserved hypothetical protein from Yersinia pestis (316 aa); YH30_HAEIN|P44298|hi1730 hypothetical protein from Haemophilus influenzae (309 aa),FASTA scores: opt: 430, E(): 3e-20, (29.6% identity in 284 aa overlap); etc. Also similar to carboxylases eg NP_415240.1|NC_000913|P75745|YBGK_ECOLI putative carboxylase from Escherichia coli strain K12 (310 aa),FASTA score: (34.6% identity in 286 aa overlap); NP_459698.1|NC_003197 putative carboxylase from Salmonella typhimurium (310 aa); and to middle part of NP_420636.1|NC_002696 urea amidolyase-related protein from Caulobacter crescentus (1207 aa). Q7U2F3 No conserved hypotheticals Rv0263c NC_002945.3 Mycobrowser_v2 CDS 314836 315828 . - 0 Mb0271c PROBABLE PERIPLASMIC IRON-TRANSPORT LIPOPROTEIN Mb0271c, -, len: 330 aa. Equivalent to Rv0265c,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Probable iron-transport lipoprotein, most similar to T36412|5763945|CAB53324.1|AL109974 probable iron-siderophore binding lipoprotein from Streptomyces coelicolor (350 aa); and (N-terminus may be incorrect) to T14166|3560508|AAC82551.1|AF027770 fxuD protein from Mycobacterium smegmatis (420 aa), FASTA scores: opt: 385,E(): 1.5e-16, (32.3% identity in 232 aa overlap). Also similar to AAB97475.1|U02617 DtxR/iron regulated lipoprotein precursor from Corynebacterium diphtheriae (355 aa); FECB_ECOLI|P15028 iron(III) dicitrate-binding periplasmic protein (300 aa), FASTA scores: opt: 191, E(): 2.3e-05, (26.5% identity in 196 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as fecB2. Q7U2F1 No cell wall and cell processes Rv0265c NC_002945.3 Mycobrowser_v2 CDS 315850 319479 . - 0 Mb0272c oplA PROBABLE 5-OXOPROLINASE OPLA (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) Mb0272c, oplA, len: 1209 aa. Equivalent to Rv0266c,len: 1209 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1209 aa overlap). Probable oplA, 5-oxoprolinase (EC 3.5.2.9), highly similar to others or to hypothetical proteins e.g. AAK24340.1|AE005906 hydantoinase/oxoprolinase from Caulobacter crescentus (1196 aa); NP_103129.1|14022305|BAB48915.1|AP002997 5-oxoprolinase from Mesorhizobium loti (1210 aa); CAC48426.1|AL603642 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (1205 aa); S77037|slr0697|1006579|BAA10729.1|D6400 HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC 6803 (1252 aa), FASTA scores: opt: 2016, E(): 0, (51.4% identity in 1247 aa overlap); P97608|OPLA_RAT|T42756|11278797 5-OXOPROLINASE (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) from Rattus norvegicus (1288 aa); etc. BELONGS TO THE OXOPROLINASE FAMILY. Q7U2F0 No NC_002945.3 Mycobrowser_v2 CDS 319656 321047 . + 0 Mb0273 narU probable integral membrane nitrite extrusion protein naru (nitrite facilitator) Mb0273, narU, len: 463 aa. Equivalent to Rv0267,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Probable narU,nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),similar to other nitrite extrusion proteins e.g. NARU_ECOLI|P37758 nitrite extrusion protein 2 from Escherichia coli (462 aa), FASTA scores: opt: 630, E(): 4.4e-33, (38.9% identity in 463 aa overlap); and NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 607, E(): 1.3e-31, (42.0% identity in 457 aa overlap). Also similar to Rv0261c, Rv2329c, Rv1737c, and to MLCB22_25 from Mycobacterium leprae (517 aa), FASTA score: (35.1 identity in 459 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS. Q7U2E9 No cell wall and cell processes Rv0267 NC_002945.3 Mycobrowser_v2 CDS 321663 322856 . - 0 Mb0275c CONSERVED HYPOTHETICAL PROTEIN Mb0275c, -, len: 397 aa. Equivalent to Rv0269c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Conserved hypothetical protein, highly similar to AL079355|SC4C6_19 hypothetical protein from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1019, E(): 0, (46.5% identity in 344 aa overlap), and similar to other proteins e.g. CAC49016.1|AL603644 putative ATP-dependent DNA ligase protein from Sinorhizobium meliloti (636 aa); O34398 YKOU PROTEIN from Bacillus subtilis (611 aa), FASTA score: (27.2% identity in 283 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3062,Rv3731 (both DNA ligases), and Rv0938, Rv3730c. Q7U2E7 No conserved hypotheticals Rv0269c NC_002945.3 Mycobrowser_v2 CDS 322892 324574 . + 0 Mb0276 fadD2 PROBABLE FATTY-ACID-COA LIGASE FADD2 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0276, fadD2, len: 560 aa. Equivalent to Rv0270,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable fadD2,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 544,E(): 2.9e-26, (27.7% identity in 535 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY493_2, MTCY8D5_9, MTCY6G11_8, etc. Contains PS00455 Putative AMP-binding domain signature. Q7U2E6 No NC_002945.3 Mycobrowser_v2 CDS 1455607 1456260 . + 0 Mb1333 conserved protein Mb1333, -, len: 217 aa. Equivalent to Rv1301, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Conserved hypothetical protein, highly similar to YRFE_MYCLE|P45831 hypothetical 22.7 kd protein in rfe-hemk intergenic region, (220 aa),FASTA scores: opt: 1168, E(): 0, (82.8% identity in 215 aa overlap). Contains PS01147 Hypothetical SUA5/yciO/yrdC family signature. BELONGS TO THE SUA5/YRDC/YCIO/YWLC FAMILY. Q7U085 No conserved hypotheticals Rv1301 NC_002945.3 Mycobrowser_v2 CDS 324591 326786 . - 0 Mb0277c fadE6 PROBABLE ACYL-COA DEHYDROGENASE FADE6 Mb0277c, fadE6, len: 731 aa. Equivalent to Rv0271c,len: 731 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 731 aa overlap). Probable fadE6,acyl-CoA dehydrogenase (EC 1.3.99.-), with C-terminal half similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase (short-chain) from Homo sapiens (412 aa),FASTA scores: opt: 339, E(): 1.3e-13, (28.1% identity in 288 aa overlap). Q7U2E5 No NC_002945.3 Mycobrowser_v2 CDS 326900 328033 . - 0 Mb0278c unknown protein Mb0278c, -, len: 377 aa. Equivalent to Rv0272c,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 377 aa overlap). Hypothetical unknown protein. Q7U2E4 No conserved hypotheticals Rv0272c NC_002945.3 Mycobrowser_v2 CDS 331762 332004 . - 0 Mb0284c PE_PGRS3b PE-PGRS FAMILY PROTEIN [SECOND PART] Mb0284c, PE_PGRS3b, len: 80 aa. Equivalent to 3' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 79 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0,(67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. No NC_002945.3 Mycobrowser_v2 CDS 331827 334433 . - 0 Mb0285c PE_PGRS3a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb0285c, PE_PGRS3a, len: 868 aa. Similar to 5' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (80.7% identity in 888 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Q7U2D8 No NC_002945.3 Mycobrowser_v2 CDS 334697 337330 . - 0 Mb0286c PE_PGRS3 PE-PGRS FAMILY PROTEIN Mb0286c, PE_PGRS3, len: 877 aa. Equivalent to Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0,(67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa). Q7U2D7 No NC_002945.3 Mycobrowser_v2 CDS 337580 340075 . - 0 Mb0287c PE_PGRS4 pe-pgrs family protein pe_pgrs4 Mb0287c, PE_PGRS4, len: 831 aa. Equivalent to Rv0279c, len: 837 aa, from Mycobacterium tuberculosis strain H37Rv, (97.4% identity in 837 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv0278c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 2677, E(): 0, (64.5% identity in 926 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions each of 9 bp (ccgccggcg-* and cccgccggc-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa). Q7U2D6 No NC_002945.3 Mycobrowser_v2 CDS 419322 419975 . + 0 Mb0356 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0356, -, len: 217 aa. Equivalent to Rv0348, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Possible transcriptional regulator, showing some similarity to O53334|RV3188|MTV014.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (115 aa), FASTA score: (30.0% identity in 100 aa overlap). Contains probable helix-turn helix motif from aa 89-110 (Score 1407, +3.98 SD). Q7U274 No regulatory proteins Rv0348 NC_002945.3 Mycobrowser_v2 CDS 340366 341976 . + 0 Mb0288 PPE3 ppe family protein ppe3 Mb0288, PPE3, len: 536 aa. Equivalent to Rv0280,len: 536 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 536 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium tuberculosis (539 aa), FASTA scores: opt: 1131, E(): 0,(51.7% identity in 540 aa overlap). Q7U2D5 No PE/PPE Rv0280 NC_002945.3 Mycobrowser_v2 CDS 342000 342908 . + 0 Mb0289 possible s-adenosylmethionine-dependent methyltransferase Mb0289, -, len: 302 aa. Equivalent to Rv0281, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Conserved hypothetical protein; member of Mycobacterium tuberculosis protein family that includes Rv0726c, Rv0731c, Rv3399,Rv1729c, etc. MTCY31_23 (325 aa), FASTA scores: opt: 1386,E(): 0, (69. 1% identity in 301 aa overlap). Contains possible N-terminal signal sequence. X2BEG3,Q7U2D4 No lipid metabolism Rv0281 NC_002945.3 Mycobrowser_v2 CDS 343132 345027 . + 0 Mb0290 ecca3 esx conserved component ecca3. esx-3 type vii secretion system protein. Mb0290, -, len: 631 aa. Equivalent to Rv0282, len: 631 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 631 aa overlap). Conserved hypothetical protein, similar to Y14967|MLCB628.18c hypothetical protein from Mycobacterium leprae (573 aa), FASTA scores: opt: 916, E(): 0, (38.7% identity in 568 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Z94121|MTY15F10.26 (619 aa), FASTA scores: opt: 743, E(): 0, (29.9% identity in 612 aa overlap). Member of CFXQ,CBXP family - 9 members in Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2D3 No cell wall and cell processes Rv0282 NC_002945.3 Mycobrowser_v2 CDS 386203 386973 . - 0 Mb0325c glpQ2 possible glycerophosphoryl diester phosphodiesterase glpq2 (glycerophosphodiester phosphodiesterase) Mb0325c, glpQ2, len: 256 aa. Equivalent to Rv0317c,len: 256 aa (start uncertain, chosen by homology), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 256 aa overlap). Possible glpQ2, glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46), similar to others e.g. E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl diester phosphodiesterase from Deinococcus radiodurans (285 aa); P10908|UGPQ_ECOLI from Escherichia coli (247 aa), FASTA scores: opt: 220, E(): 5.2e-07, (28.0% identity in 250 aa overlap). Also similar to MTCY01A6.27 from Mycobacterium tuberculosis FASTA score: (27.5% identity in 247 aa overlap). Q7U2A0 No NC_002945.3 Mycobrowser_v2 CDS 2196500 2196907 . - 0 Mb1997c vapc35 possible toxin vapc35. contains pin domain. Mb1997c, -, len: 135 aa. Equivalent to Rv1962c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv3408|MTCY78.20c (133 aa) (36.2% identity in 138 aa overlap); and Rv3384c (130 aa) (43.1% identity in 130 aa overlap) Q7TZ71 No virulence, detoxification, adaptation Rv1962c NC_002945.3 Mycobrowser_v2 CDS 345024 346640 . + 0 Mb0291 eccb3 esx conserved component eccb3. esx-3 type vii secretion system protein. possible membrane protein. Mb0291, -, len: 538 aa. Equivalent to Rv0283, len: 538 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 538 aa overlap). Possible conserved membrane protein, similar to several hypothetical mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 698, E(): 0, (37.6% identity in 492 aa overlap); Rv1782; Rv3450c; Rv3869; and Y14967|MLCB628_16|MLCB628.17c from Mycobacterium leprae (481 aa), FASTA scores: opt: 672, E(): 1.5e-31, (37.2% identity in 506 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2D2 No cell wall and cell processes Rv0283 NC_002945.3 Mycobrowser_v2 CDS 346637 350629 . + 0 Mb0292 eccc3 esx conserved component eccc3. esx-3 type vii secretion system protein. possible membrane protein. Mb0292, -, len: 1330 aa. Equivalent to Rv0284, len: 1330 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1330 aa overlap). Possible conserved membrane protein, similar to products of two adjacent Mycobacterium leprae genes, MLCB628.16c (744 aa) and MLCB628.15c (597 aa); and throughout its length to several large Mycobacterium tuberculosis proteins: Rv3447c,Rv3870, Rv1784, etc. Y14967|MLCB628_ 15 (744 aa), FASTA scores: opt: 942, E(): 0, (33.8% identity in 730 aa overlap); Y14967|MLCB628_14 (597 aa), FASTA scores: opt: 613, E(): 3.1e-30, (31.7% identity in 615 aa overlap); Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap); Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap). Contains three PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2D1 No cell wall and cell processes Rv0284 NC_002945.3 Mycobrowser_v2 CDS 350626 350934 . + 0 Mb0293 PE5 pe family protein pe5 Mb0293, PE5, len: 102 aa. Equivalent to Rv0285,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below), similar to others e.g. AL0212|MTV012_37 from Mycobacterium tuberculosis (105 aa), FASTA scores: opt: 497, E(): 2.6e-24, (80.4% identity in 102 aa overlap); Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity in 102 aa overlap); etc. Q7U2D0 No PE/PPE Rv0285 NC_002945.3 Mycobrowser_v2 CDS 350937 352478 . + 0 Mb0294 PPE4 ppe family protein ppe4 Mb0294, PPE4, len: 513 aa. Equivalent to Rv0286,len: 513 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 513 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 958, E(): 0, (43.5% identity in 522 aa overlap). Q7U2C9 No PE/PPE Rv0286 NC_002945.3 Mycobrowser_v2 CDS 2130400 2130711 . + 0 Mb1925 PROBABLE MEMBRANE PROTEIN Mb1925, -, len: 103 aa. Equivalent to Rv1892, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Probable membrane protein. Q7TZC5 No cell wall and cell processes Rv1892 NC_002945.3 Mycobrowser_v2 CDS 352527 352820 . + 0 Mb0295 esxG esat-6 like protein esxg (conserved protein tb9.8) Mb0295, esxG, len: 97 aa. Equivalent to Rv0287,len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). esxG, conserved hypothetical protein. PE-family related protein; distant member of the Mycobacterium tuberculosis PE family,similar to Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt: 564, E(): 0, (91.8% identity in 97 aa overlap). Contains probable helix-turn-helix motif at aa 14-35 (Score 144, +4.11 SD). SEEMS TO BELONG TO THE ESAT6 FAMILY (see third citation below). Q7U2C8 No cell wall and cell processes Rv0287 NC_002945.3 Mycobrowser_v2 CDS 352850 353140 . + 0 Mb0296 esxH low molecular weight protein antigen 7 esxh (10 kda antigen) (cfp-7) (protein tb10.4) Mb0296, esxH, len: 96 aa. Equivalent to Rv0288,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). esxH (alternate gene name: TB10.4), low molecular weight protein antigen 7 (10 kDa antigen) (CFP-7) (Protein TB10.4) (see citations below), ala-rich protein; member of mycobacterial protein family containing ESAT-6, very similar to MTV012_33 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 566, E(): 0, (84.4% identity in 96 aa overlap). Alternative start codon possible position 351878 (see second citation). BELONG TO THE ESAT6 FAMILY (see first,sixth and seventh citations below). X2BEL4 No cell wall and cell processes Rv0288 NC_002945.3 Mycobrowser_v2 CDS 353151 354038 . + 0 Mb0297 espg3 esx-3 secretion-associated protein espg3 Mb0297, -, len: 295 aa. Equivalent to Rv0289, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Conserved hypothetical protein, equivalent to CAC32061.1|AL583926 possible DNA-binding protein from Mycobacterium leprae (289 aa); and showing some similarity to Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from Mycobacterium tuberculosis (276 aa), FASTA scores: opt: 149, E(): 0.0035, (27.7% identity in 289 aa overlap). Q7U2C7 No cell wall and cell processes Rv0289 NC_002945.3 Mycobrowser_v2 tRNA 387234 387304 . - 0 glyU glyU tRNA-Gly glyU, len: 71 nt. Equivalent to glyU, len: 71 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 nt overlap). tRNA-Gly, anticodon ccc. No NC_002945.3 Mycobrowser_v2 CDS 354085 355503 . + 0 Mb0298 eccd3 esx conserved component eccd3. esx-3 type vii secretion system protein. probable transmembrane protein. Mb0298, -, len: 472 aa. Equivalent to Rv0290, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable conserved transmembrane protein, similar to several others in mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from Mycobacterium tuberculosis (467 aa), FASTA scores: opt: 429, E(): 5.1e-19, (28. 6% identity in 479 aa overlap); Rv3877; Rv1795; Rv3448; and Y14967|MLCB628_9|MLCB628.10c from Mycobacterium leprae (480 aa), FASTA scores: opt: 269, E(): 3.1e-09, (26.0% identity in 503 aa overlap). TBparse score is 0.892. Q7U2C6 No cell wall and cell processes Rv0290 NC_002945.3 Mycobrowser_v2 CDS 355500 356885 . + 0 Mb0299 mycp3 probable membrane-anchored mycosin mycp3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) Mb0299, -, len: 461 aa. Equivalent to Rv0291, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable protease precursor (EC 3.4.-.-), similar to several others in mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from Mycobacterium leprae (446 aa), FASTA scores: opt: 1159,E(): 0, (43.5 identity in 446 aa overlap). Has signal sequence and hydrophobic stretch at C-terminus, followed by short positively charged segment, that could act as membrane anchor. Shows similarity to several members of the subtilase family and contains PS00137 Serine proteases, subtilase family, histidine active site signature. Q7U2C5 No intermediary metabolism and respiration Rv0291 NC_002945.3 Mycobrowser_v2 CDS 356882 357877 . + 0 Mb0300 ecce3 esx conserved component ecce3. esx-3 type vii secretion system protein. probable transmembrane protein. Mb0300, -, len: 331 aa. Equivalent to Rv0292, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 331 aa overlap). Probable conserved transmembrane protein (has two hydrophobic segments at N-terminal end), equivalent to CAC32058.1|AL583926 conserved membrane protein from Mycobacterium leprae (339 aa). Q7U2C4 No cell wall and cell processes Rv0292 NC_002945.3 Mycobrowser_v2 CDS 357864 359066 . - 0 Mb0301c conserved protein Mb0301c, -, len: 400 aa. Equivalent to Rv0293c,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 400 aa overlap). Conserved hypothetical protein, similar in C-terminal part to Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (413 aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity in 299 aa overlap). TBparse score is 0.922. Q7U2C3 No conserved hypotheticals Rv0293c NC_002945.3 Mycobrowser_v2 CDS 359173 359958 . + 0 Mb0302 tam PROBABLE TRANS-ACONITATE METHYLTRANSFERASE TAM Mb0302, tam, len: 261 aa. Equivalent to Rv0294,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 261 aa overlap). Probable tam,trans-aconitate methyltransferase (EC 2.1.1.-), similar to others e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 TRANS-ACONITATE METHYLTRANSFERASE from Escherichia coli strain K12 (252 aa), FASTA scores: opt: 649, E(): 0, (39.3 identity in 252 aa overlap). BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. X2BEL6,P66886 No intermediary metabolism and respiration Rv0294 NC_002945.3 Mycobrowser_v2 CDS 359947 360750 . - 0 Mb0303c conserved protein Mb0303c, -, len: 267 aa. Equivalent to Rv0295c,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 267 aa overlap). Conserved hypothetical protein, showing weak similarity with CAC46877.1|AL591790 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (213 aa); and NP_104818.1|14023999|BAB50604.1|AP00300 Protein with weak similarity to NodH from Mesorhizobium loti (257 aa). Q7U2C2 No conserved hypotheticals Rv0295c NC_002945.3 Mycobrowser_v2 CDS 387335 388129 . - 0 Mb0326c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0326c, -, len: 264 aa. Equivalent to Rv0318c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable conserved integral membrane protein, with some similarity to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: opt: 157, E (): 0.0032, (28.3% identity in 198 aa overlap). Also similar to O26573 CONSERVED PROTEIN from Methanobacterium thermoauto (259 aa), FASTA scores: opt: 173, E(): 5.2e-05, (32.7% identity in 214 aa overlap). Q7U299 No cell wall and cell processes Rv0318c NC_002945.3 Mycobrowser_v2 CDS 4320326 4320775 . - 0 Mb3931c POSSIBLE MEMBRANE PROTEIN Mb3931c, -, len: 149 aa. Equivalent to Rv3901c,len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 149 aa overlap). Possible membrane protein (hydrophobic stretch from ~30-52), showing some similarity with O53200|Rv2473|MTV008.29 HYPOTHETICAL 25.1 KDA PROTEIN from Mycobacterium tuberculosis (238 aa),FASTA scores: opt: 147, E(): 0.036, (31.35% identity in 134 aa overlap). Q7TVE0 No cell wall and cell processes Rv3901c NC_002945.3 Mycobrowser_v2 CDS 360760 362157 . - 0 Mb0304c PROBABLE SULFATASE Mb0304c, -, len: 465 aa. Equivalent to Rv0296c,len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 465 aa overlap). Probable sulfatase,possibly an aryl-/steryl-sulfatase (EC 3.1.6.-) or a sulfamidase (sulfohydrolase) (sulphamidase) (EC 3.10.1.-). Similar to various hydrolases e.g. AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus musculus (502 aa); NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 N-sulfoglucosamine sulfohydrolase (sulfamidase) (sulphamidase) from Mus musculus (502 aa); AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC) from Homo sapiens (583 aa); ARSB_FELCA|P33727 arylsulfatase B precursor (EC 3.1.6.1) (535 aa), FASTA scores: opt: 231, E(): 1.7e-08, (30.3% identity in 261 aa overlap). Also similarity with 4 others sulfatases in Mycobacterium tuberculosis. Contains sulfatases signature 1 (PS00523). Note that previously known as atsG. Q7U2C1 No intermediary metabolism and respiration Rv0296c NC_002945.3 Mycobrowser_v2 CDS 362336 364156 . + 0 Mb0305 PE_PGRS5 pe-pgrs family protein pe_pgrs5 Mb0305, PE_PGRS5, len: 606 aa. Equivalent to Rv0297, len: 591 aa, from Mycobacterium tuberculosis strain H37Rv, (97.5% identity in 606 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Y03A_MYCTU|Q10637 from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 1884, E(): 0, (53.7% identity in 635 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa). Q7U2C0 No PE/PPE Rv0297 NC_002945.3 Mycobrowser_v2 CDS 364299 364526 . + 0 Mb0306 HYPOTHETICAL PROTEIN Mb0306, -, len: 75 aa. Equivalent to Rv0298, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Hypothetical unknown protein. Q7U2B9 No conserved hypotheticals Rv0298 NC_002945.3 Mycobrowser_v2 CDS 365652 366284 . + 0 Mb0310 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY) Mb0310, -, len: 210 aa. Equivalent to Rv0302, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 210 aa overlap). Probable transcription regulatory protein, TetR family, with its N-terminus similar to N-terminus of several repressors and regulatory proteins of TetR/AcrR family e.g. ACRR_ECOLI|P34000 potential acraB operon repressor from Escherichia coli (215 aa), FASTA scores: opt: 172, E(): 3.1e-05, (22.7% identity in 194 aa overlap). Also similar in N-terminus to N-terminus of MTCY07A7.24 hypothetical regulator from Mycobacterium tuberculosis FASTA score: (38.7% identity in 62 aa overlap). Contains probable helix-turn helix motif from aa 35-56 (Score 1728, +5.07 SD). Q7U2B5 No regulatory proteins Rv0302 NC_002945.3 Mycobrowser_v2 CDS 366281 367189 . + 0 Mb0311 PROBABLE DEHYDROGENASE/REDUCTASE Mb0311, -, len: 302 aa. Equivalent to Rv0303, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various NADPH dehydrogenases and other NADPH oxidoreductases e.g. O48741|PORC_ARATH|7488284|T00897 PROTOCHLOROPHYLLIDE REDUCTASE C CHLOROPLAST PRECURSOR (EC 1.3.1.33) (NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE C) from Arabidopsis thaliana (401 aa); Q42850 NADPH DEHYDROGENASE (EC 1.6.99. 1) (395 aa), FASTA scores: opt: 347, E(): 3.8e-16, (35.4% identity in 319 aa overlap). Q7U2B4 No intermediary metabolism and respiration Rv0303 NC_002945.3 Mycobrowser_v2 CDS 370784 376741 . - 0 Mb0313c PPE6 ppe family protein ppe6 Mb0313c, PPE6, len: 1985 aa. Equivalent to 5' end of Rv0305c, len: 963 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 809 aa overlap). Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Y04H_MYCTU|Q10778 from M. tuberculosis (734 aa), FASTA scores: opt: 1340, E(): 0,(40.9% identity in 815 aa overlap); Z95324|MTY13E10_16 from Mycobacterium tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0, (42.3% identity in 522 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis, a single base deletion (t-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Q7U2B2 No NC_002945.3 Mycobrowser_v2 CDS 376944 377615 . + 0 Mb0314 PUTATIVE OXIDOREDUCTASE Mb0314, -, len: 223 aa. Equivalent to Rv0306, len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Putative oxidoreductase (EC 1.-.-.-), highly similar to H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved hypothetical protein from Pseudomonas aeruginosa strain PAO1 (218 aa); and to other putative oxidoreductases e.g. middle part of CAB76073.1|AL157953 putative nitroreductase from Streptomyces coelicolor (1212 aa); Q52685|BLUB protein involved in cobalamin (vitamin B12) synthesis from Rhodobacter capsulatus (206 aa), FASTA scores: opt: 318,E(): 2e-15, (35.6% identity in 191 aa overlap). Q7U2B1 No intermediary metabolism and respiration Rv0306 NC_002945.3 Mycobrowser_v2 CDS 377603 378085 . - 0 Mb0315c unknown protein Mb0315c, -, len: 160 aa. Equivalent to Rv0307c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein. Q7U2B0 No conserved hypotheticals Rv0307c NC_002945.3 Mycobrowser_v2 CDS 378143 378859 . + 0 Mb0316 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0316, -, len: 238 aa. Equivalent to Rv0308, len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Probable conserved integral membrane protein, with C-terminus highly similar to C-terminus of other integral membrane proteins or phosphatases e.g. AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 putative phosphatase from Streptococcus pyogenes (201 aa); Q06074 HYPOTHETICAL 24.9 KD PROTEIN (216 aa), FASTA scores: opt: 209, E(): 2e-07, (27.9% identity in 140 aa overlap). Could be a phosphatase. Q7U2A9 No cell wall and cell processes Rv0308 NC_002945.3 Mycobrowser_v2 CDS 378961 379617 . + 0 Mb0317 POSSIBLE CONSERVED EXPORTED PROTEIN Mb0317, -, len: 218 aa. Equivalent to Rv0309, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Possible conserved exported protein (has putative N-terminal signal sequence), equivalent to AC32053.1|AL583926 putative secreted protein from Mycobacterium leprae (218 aa). Also similar to others e.g. AB76092.1|AL157956 putative secreted protein from Streptomyces coelicolor (238 aa). Q7U2A8 No cell wall and cell processes Rv0309 NC_002945.3 Mycobrowser_v2 CDS 379687 380178 . - 0 Mb0318c conserved protein Mb0318c, -, len: 163 aa. Equivalent to Rv0310c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 BILE ACID-INDUCIBLE OPERON PROTEIN E from Eubacterium sp (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% identity in 134 aa overlap); AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa). Q7U2A7 No conserved hypotheticals Rv0310c NC_002945.3 Mycobrowser_v2 CDS 390290 391621 . + 0 Mb0330 udgA PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH) Mb0330, udgA, len: 443 aa. Equivalent to Rv0322,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 443 aa overlap). Probable udg (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase (EC 1.1.1.22), highly similar to others e.g. CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase from Streptomyces coelicolor (447 aa); Q56812 UDP-GLUCOSE DEHYDROGENASE from Xanthomonas campestris (445 aa), FASTA scores: opt: 713, E(): 0, (41.9% identity in 351 aa overlap); etc. Also similar to several GDP-mannose 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UDP-GLUCOSE/GDP-MANNOSE DEHYDROGENASES FAMILY. Q7U296 No intermediary metabolism and respiration Rv0322 NC_002945.3 Mycobrowser_v2 CDS 381586 383448 . + 0 Mb0320 CONSERVED HYPOTHETICAL PROLINE AND THREONINE RICH PROTEIN Mb0320, -, len: 620 aa. Equivalent to Rv0312, len: 620 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 620 aa overlap). Conserved hypothetical protein with highly Pro-, Thr-rich C-terminus. Similar to Pro-,Thr-rich region in Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis (592 aa), FASTA scores: opt: 1075, E(): 0, (38.9% identity in 627 aa overlap). Also some similarity with Rv0350|dnaK from Mycobacterium tuberculosis. Possibly membrane protein; has hydrophobic stetch in its middle part. Q7U2A5 No conserved hypotheticals Rv0312 NC_002945.3 Mycobrowser_v2 CDS 388178 388846 . + 0 Mb0327 pcp PROBABLE PYRROLIDONE-CARBOXYLATE PEPTIDASE PCP (5-OXOPROLYL-PEPTIDASE) (PYROGLUTAMYL-PEPTIDASE I) (PGP-I) (PYRASE) Mb0327, pcp, len: 222 aa. Equivalent to Rv0319,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable pcp,pyrrolidone-carboxylate peptidase (EC 3.4.19.3), highly similar to others e.g. PCP_PSEFL|P42673 pyrrolidone-carboxylate peptidase from Pseudomonas fluorescens (213 aa), FASTA scores: opt: 478, E(): 7.5e-25, (40.2% identity in 219 aa overlap). BELONGS TO PEPTIDASE FAMILY C15 (THIOL PROTEASE). X2BEP1,P0A5R5 No intermediary metabolism and respiration Rv0319 NC_002945.3 Mycobrowser_v2 CDS 388918 389580 . + 0 Mb0328 POSSIBLE CONSERVED EXPORTED PROTEIN Mb0328, -, len: 220 aa. Equivalent to Rv0320, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Possible conserved exported protein, similar to some hypothetical proteins and to the middle part of a peptidase: NP_066789.1|10657900|AAG21739.1|AF116907 putative peptidase from Rhodococcus equi (546 aa). Also similar to Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity in 225 aa overlap). Q7U298 No cell wall and cell processes Rv0320 NC_002945.3 Mycobrowser_v2 CDS 389612 390184 . + 0 Mb0329 dcd PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) Mb0329, dcd, len: 190 aa. Equivalent to Rv0321,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 190 aa overlap). Probable dcd (alterrnate gene names: dus or paxA), deoxycytidine triphosphate deaminase (EC 3.5.4.13), equivalent to CAC32024.1|AL583925 probable deoxycytidine triphosphate deaminase from Mycobacterium leprae (190 aa). Also highly similar to others e.g. Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE from Streptomyces coelicolor (191 aa); DCD_ECOLI|P28248|DUS|PAXA|B2065 DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE from Escherichia coli strain K12 (193 aa), FASTA scores: opt: 408, E(): 2.7e-21, (43.1% identity in 188 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE DCTP DEAMINASE FAMILY. X2BEL5,Q7U297 No intermediary metabolism and respiration Rv0321 NC_002945.3 Mycobrowser_v2 CDS 391610 392281 . - 0 Mb0331c CONSERVED HYPOTHETICAL PROTEIN Mb0331c, -, len: 223 aa. Equivalent to Rv0323c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 223 aa overlap). Conserved hypothetical protein, similar to others e.g. YPJG_BACSU|P42981 hypothetical 24.8 kd protein from Bacillus subtilis (224 aa), FASTA scores: opt: 182, E(): 1.3e-05, (27.5% identity in 211 aa overlap). Also some similarity to MLU15183_8 from Mycobacterium tuberculosis FASTA score: (32.0% identity in 147 aa overlap). Q7U295 No conserved hypotheticals Rv0323c NC_002945.3 Mycobrowser_v2 CDS 392382 393062 . + 0 Mb0332 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY) Mb0332, -, len: 226 aa. Equivalent to Rv0324, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Possible transcriptional regulator, arsR family, with its N-terminus similar to the N-terminus of other DNA-binding proteins e.g. P30346|MERR_STRLI probable mercury resistance operon from Streptomyces lividans (125 aa),FASTA scores: opt: 154, E(): 0.002, (32.2% identity in 90 aa overlap)), and its C-terminal part similar to hypothetical bacterial proteins e.g. P54510|YQHL_BACSU hypothetical 14.6 kd protein from Bacillus subtilis (126 aa), FASTA scores: opt: 159, E(): 0.00097, (35.5% identity in 76 aa overlap)). Most similar to AJ005575|SPE005575_2 ORF1 required for antibiotic production from Streptomyces peucetius (226 aa), FASTA scores: opt: 816, E(): 0, (60.7% identity in 211 aa overlap). Also similar in C-terminus to MTCY164.26 molybdopterin biosynthesis moeb protein from Mycobacterium tuberculosis FASTA score: (36.8% identity in 114 aa overlap). Q7U294 No regulatory proteins Rv0324 NC_002945.3 Mycobrowser_v2 CDS 393069 393758 . + 0 Mb0333 HYPOTHETICAL PROTEIN Mb0333, -, len: 229 aa. Equivalent to Rv0325 and Rv0326, len: 74 aa and 151 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 aa overlap and 100.0% identity in 151 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (t-c) leads to single product. Q7U293 No unknown Rv0325 NC_002945.3 Mycobrowser_v2 CDS 393726 395075 . - 0 Mb0334c cyp135A1 POSSIBLE CYTOCHROME P450 135A1 CYP135A1 Mb0334c, cyp135A1, len: 449 aa. Equivalent to Rv0327c, len: 449 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 449 aa overlap). Possible cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() : 1.7e-11, (27.9% identity in 433 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in 434 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. Alternative start possible at 33706 but no RBS. Q7U292 No NC_002945.3 Mycobrowser_v2 CDS 399688 400554 . + 0 Mb0341 rmlA alpha-d-glucose-1-phosphate thymidylyltransferase rmla (dtdp-glucose synthase) (dtdp-glucose pyrophosphorylase) Mb0341, rmlA, len: 288 aa. Equivalent to Rv0334,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap). Probable rmlA (alternate gene name: rfbA), glucose-1-phosphate thymidylyl-transferase (EC 2.7.7.24), equivalent to CAC32020.1|AL583925 glucose-1-phosphate thymidyltransferase from Mycobacterium leprae (288 aa). Also highly similar to others e.g. AAG29804.1|AF235050 glucose-1-phosphate thymidylyltransferase from Streptomyces rishiriensis (296 aa); RBA1_ECOLI|P37744 glucose-1-phosphate thymidylyltransferase from Escherichia coli strain K12 (293 aa), FASTA scores: opt: 1199, E(): 0,(62.0% identity in 284 aa overlap). BELONGS TO THE GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE FAMILY. Q7U285 No intermediary metabolism and respiration Rv0334 NC_002945.3 Mycobrowser_v2 CDS 395141 395743 . + 0 Mb0335 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR/ACRR-FAMILY) Mb0335, -, len: 200 aa. Equivalent to Rv0328, len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Possible transcription regulator, tetR/acrR family, similar in part to various hypothetical transcriptional regulators e.g. T36696|4726006|CAB41735.1|AL049731 probable regulatory protein from Streptomyces coelicolor (197 aa). Also some similarity with YX44_MYCTU|Q10829 hypothetical transcriptional regulator from Mycobacterium tuberculosis (195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7% identity in 202 aa overlap). Contains probable helix-turn helix motif from aa 27-48 (Score 1408, +3.98 SD). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U291 No regulatory proteins Rv0328 NC_002945.3 Mycobrowser_v2 CDS 395724 396350 . - 0 Mb0336c CONSERVED HYPOTHETICAL PROTEIN Mb0336c, -, len: 208 aa. Equivalent to Rv0329c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 208 aa overlap). Conserved hypothetical protein, showing some similarity with others hypothetical proteins and methyltransferases e.g. MitM|AF127374_14 methyltransferase from Streptomyces lavendulae (283 aa),FASTA scores: opt: 242, E(): 1.8e-08, (37.2% identity in 145 aa overlap); Q48938 from Methanosarcina barkeri (262 aa), FASTA scores: opt: 194, E(): 3.6e-06, (31.1% identity in 119 aa overlap). Q7U290 No conserved hypotheticals Rv0329c NC_002945.3 Mycobrowser_v2 CDS 397231 398397 . + 0 Mb0338 POSSIBLE DEHYDROGENASE/REDUCTASE Mb0338, -, len: 388 aa. Equivalent to Rv0331, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein reductase from Mesorhizobium loti (377 aa); NP_147681.1 predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% identity in 348 aa overlap). TBparse score is 0.906. Q7U288 No intermediary metabolism and respiration Rv0331 NC_002945.3 Mycobrowser_v2 CDS 398472 399257 . + 0 Mb0339 conserved protein Mb0339, -, len: 261 aa. Equivalent to Rv0332, len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 261 aa overlap). Conserved hypothetical protein, similar to several conserved hypothetical proteins from Streptomyces coelicolor e.g. SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% identity in 251 aa overlap). Q7U287 No conserved hypotheticals Rv0332 NC_002945.3 Mycobrowser_v2 CDS 399284 399658 . + 0 Mb0340 unknown protein Mb0340, -, len: 124 aa. Equivalent to Rv0333, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Hypothetical unknown protein. Q7U286 No conserved hypotheticals Rv0333 NC_002945.3 Mycobrowser_v2 CDS 401222 402733 . + 0 Mb0343 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0343, -, len: 503 aa. Equivalent to Rv0336, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Part of Mycobacterium tuberculosis 13E12 repeat family; almost identical to Rv0515|MTCY20G10.05 hypothetical protein from M. tuberculosis FASTA scores: (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1148c, Rv1945, etc. Q7TTD9 No insertion seqs and phages Rv0336 NC_002945.3 Mycobrowser_v2 CDS 402903 404192 . - 0 Mb0344c aspC PROBABLE ASPARTATE AMINOTRANSFERASE ASPC (TRANSAMINASE A) (ASPAT) Mb0344c, aspC, len: 429 aa. Equivalent to Rv0337c,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Probable aspC,aspartate aminotransferase (transaminase A) (EC 2.6.1.1),equivalent to CAC32019.1|AL583925 probable aspartate aminotransferase from Mycobacterium leprae (437 aa). Also highly similar to many e.g. Q48143|U32823 aspartate aminotransferase (404 aa), FASTA scores: opt: 1646, E(): 0, (57.2% identity in 404 aa overlap). Also some similarity to Rv3565|MTCY06G11.12 from Mycobacterium tuberculosis FASTA score: (27.2% identity in 383 aa overlap). BELONGS TO CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BEM9,P63499 No NC_002945.3 Mycobrowser_v2 CDS 404223 406871 . - 0 Mb0345c probable iron-sulfur-binding reductase Mb0345c, -, len: 882 aa. Equivalent to Rv0338c,len: 882 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 882 aa overlap). Probable iron-sulphur-binding reductase (EC 1.-.-.-), possibly membrane-bound, equivalent to CAC32018.1|AL583925 probable iron-sulphur-binding reductase from Mycobacterium leprae (880 aa). Also highly similar to others e.g. T36608|5019323|CAB44376.1|AL078610 probable iron-sulfur-binding reductase from Streptomyces coelicolor (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity in 772 aa overlap); BAB07521.1|AP001520 iron-sulphur-binding reductase from Bacillus halodurans (700 aa). Contains PS00070 Aldehyde dehydrogenases cysteine active site and two of PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. First of several possible start sites chosen. Q7U283 No intermediary metabolism and respiration Rv0338c NC_002945.3 Mycobrowser_v2 CDS 406980 409478 . - 0 Mb0346c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0346c, -, len: 832 aa. Equivalent to Rv0339c,len: 832 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 832 aa overlap). Possible transcriptional regulator, showing very weak similarity with parts of others. Contains PS00017 ATP/GTP-binding site motif A (P-loop ); and probable helix-turn helix motif from aa 778-799 (Score 1041, +2.73 SD). Q7U282 No regulatory proteins Rv0339c NC_002945.3 Mycobrowser_v2 CDS 409664 410203 . + 0 Mb0347 conserved protein Mb0347, -, len: 179 aa. Equivalent to Rv0340, len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Conserved hypothetical protein; MEME-MAST analysis shows similarity to product of downstream gene, Rv0341|iniB. Q7U281 No conserved hypotheticals Rv0340 NC_002945.3 Mycobrowser_v2 CDS 410392 411831 . + 0 Mb0348 iniB ISONIAZID INDUCTIBLE GENE PROTEIN INIB Mb0348, iniB, len: 479 aa. Equivalent to Rv0341,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). iniB,isoniazid-inducible gene, (see citations below). Protein very Gly-, Ala-rich, similar to cell wall proteins e.g. P27483|GRP_ARATH GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN from A.thaliana (338 aa), FASTA scores: opt: 532, E(): 5.2e-13, (39.3% identity in 321 aa overlap). MEME-MAST analysis shows similarity to product of upstream gene,Rv0340. Q7U280 No cell wall and cell processes Rv0341 NC_002945.3 Mycobrowser_v2 CDS 411868 413790 . + 0 Mb0349 iniA ISONIAZID INDUCTIBLE GENE PROTEIN INIA Mb0349, iniA, len: 640 aa. Equivalent to Rv0342,len: 640 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 640 aa overlap). iniA,isoniazid-inducible gene, (see citations below). Shows slight similarity to some hypothetical bacterial proteins e.g. P40983|YOR6_THER hypothetical protein (402 aa), FASTA scores: opt: 242, E(): 1.4e-07, (22.3% identity in 349 aa overlap). Also some similarity to downstream ORF Rv0343|iniC. Possible transmembrane stretch around residue 490. Alternative translational start at 410824. Contains a phosphopantetheine attachment site motif suggestive of an acyl carrier protein. Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid. Q7U279 No cell wall and cell processes Rv0342 NC_002945.3 Mycobrowser_v2 CDS 413787 415268 . + 0 Mb0350 iniC ISONIAZID INDUCTIBLE GENE PROTEIN INIC Mb0350, iniC, len: 493 aa. Equivalent to Rv0343,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 493 aa overlap). iniC,isoniazid-inducible gene, (see citations below). Shows slight similarity to P40983|YOR6_THER8 hypothetical protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05,(25.9% identity in 228 aa overlap). Also some similarity to upstream ORF Rv0342|iniA. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid. Q7U278 No cell wall and cell processes Rv0343 NC_002945.3 Mycobrowser_v2 CDS 415411 415971 . - 0 Mb0351c lpqJ PROBABLE LIPOPROTEIN LPQJ Mb0351c, lpqJ, len: 186 aa. Equivalent to Rv0344c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Probable lipoprotein,without homology. Has an appropriately positioned prokaryotic lipoprotein signature (PS00013). Q7U277 No NC_002945.3 Mycobrowser_v2 CDS 416217 416489 . + 0 Mb0353 CONSERVED HYPOTHETICAL PROTEIN Mb0353, -, len: 90 aa. Equivalent to 3' end of Rv0345, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 188, E(): 1.5e-05, (41.0% identity in 117 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U276 No NC_002945.3 Mycobrowser_v2 CDS 416531 417994 . - 0 Mb0354c ansP2 POSSIBLE L-ASPARAGINE PERMEASE ANSP2 (L-ASPARAGINE TRANSPORT PROTEIN) Mb0354c, ansP2, len: 487 aa. Equivalent to Rv0346c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 487 aa overlap). Possible ansP2,L-asparagine permease, integral membrane protein belonging to family containing many amino acid permeases, highly similar to G467030|B2126_F2_85|NP_301937.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (498 aa); and NP_301938.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (505 aa). Also highly similar to others e.g. P77610|ANSP_ECOLI L-ASPARAGINE PERMEASE from Escherichia coli strain K-12 (499 aa). Also highly similar to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 PROBABLE L-ASPARAGINE PERMEASE from Mycobacterium tuberculosis (489 aa), FASTA score: (72.1% identity in 473 aa overlap). And shows some similarity to MTCY3G12.14 from Mycobacterium tuberculosis. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Note that previously known as aroP2. X2BES8,P0A4W1 No NC_002945.3 Mycobrowser_v2 CDS 418333 419319 . + 0 Mb0355 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0355, -, len: 328 aa. Equivalent to Rv0347, len: 328 aa (alternative start possible), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 328 aa overlap). Probable conserved membrane protein, similar to Rv0831c|AL022004|MTV043_23 from Mycobacterium tuberculosis (271 aa), FASTA scores: E(): 9.6e-21, (33.1% identity in 266 aa overlap). Q7U275 No cell wall and cell processes Rv0347 NC_002945.3 Mycobrowser_v2 CDS 435847 436491 . - 0 Mb0363c conserved protein Mb0363c, -, len: 214 aa. Equivalent to Rv0356c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1067, E(): 0, (73.4% identity in 214 aa overlap). Q7U269 No conserved hypotheticals Rv0356c NC_002945.3 Mycobrowser_v2 CDS 420864 422741 . + 0 Mb0358 dnaK PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70) Mb0358, dnaK, len: 625 aa. Equivalent to Rv0350,len: 625 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 625 aa overlap). Probable DnaK (alternate gene name: hsp70), 70 kDa heat shock protein (see citations below), equivalent to AAA25362.1|M95576|1924344A|738248 heat shock protein 70 from Mycobacterium leprae (621 aa); and DNAK_MYCPA|Q00488 (623 aa), FASTA scores: opt: 3678, E(): 0, (92.3% identity in 625 aa overlap). Also highly similar to others e.g. Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 CHAPERONE PROTEIN DNAK from Streptomyces coelicolor (618 aa). Has probably an ATPase activity (EC 3.6.1.-). Note that this sequence differs from DNAK_MYCTU|P32723 (609 aa), due to a frameshift near the N-terminus. BELONGS TO THE HEAT SHOCK PROTEIN 70 FAMILY. X2BES1,P0A5C0 No virulence, detoxification, adaptation Rv0350 NC_002945.3 Mycobrowser_v2 CDS 422738 423445 . + 0 Mb0359 grpE PROBABLE GRPE PROTEIN (HSP-70 COFACTOR) Mb0359, grpE, len: 235 aa. Equivalent to Rv0351,len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 235 aa overlap). Probable grpE protein (HSP-70 COFACTOR), equivalent to CAC32012.1|AL583925 Hsp70 cofactor from Mycobacterium leprae (229 aa). Also highly similar to others eg Q05562|GRPE_STRCO|2127521|PN0643 GRPE PROTEIN from Streptomyces coelicolor (225 aa). Contains grpE protein signature (PS01071). BELONGS TO THE GRPE FAMILY. X2BET3,Q7U272 No virulence, detoxification, adaptation Rv0351 NC_002945.3 Mycobrowser_v2 CDS 423481 424668 . + 0 Mb0360 dnaJ1 PROBABLE CHAPERONE PROTEIN DNAJ1 Mb0360, dnaJ1, len: 395 aa. Equivalent to Rv0352,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 395 aa overlap). Probable DnaJ1,chaperone protein, equivalent to AAA25363.1|M95576 DNA J heatshock protein from Mycobacterium leprae (389 aa). Also highly similar to others. Contains both DnaJ signatures (PS00636, and PS00637). BELONGS TO THE DNAJ FAMILY. COFACTOR: BINDS TWO ZINC IONS PER MONOMER. Note that sequence differs from DNAJ_MYCTU|P07881 due to a frameshift at the N-terminus. Note that previously known as dnaJ. X2BEP4,P0A549 No NC_002945.3 Mycobrowser_v2 CDS 424668 425048 . + 0 Mb0361 hspR probable heat shock protein transcriptional repressor hspr (merr family) Mb0361, hspR, len: 126 aa. Equivalent to Rv0353,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Probable hspR, heat shock regulatory protein, merR family, highly similar to others e.g. HspR|P40183 heat shock regulatory protein from Streptomyces coelicolor (151 aa), FASTA scores: E(): 4.9e-22, (55.7% identity in 140 aa overlap), that binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon. Has possible coiled coil region in C-terminal half. BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U271 No virulence, detoxification, adaptation Rv0353 NC_002945.3 Mycobrowser_v2 CDS 425173 435696 . - 0 Mb0362c PPE8 ppe family protein ppe7 Mb0362c, PPE8, len: 3507 aa. Equivalent to Rv0355c and Rv0354c, len: 3300 aa and 141 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 3296 aa overlap and 100.0% identity in 125 aa overlap). PPE8,member of the Mycobacterium tuberculosis PPE family,similar to others e.g. AL009198|MTV004_5 from M. tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0,(40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17, E(): 0; MTCY98.0034c,E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; MTCY31.06c, E(): 5.6e-17; MTCY359.33, E(): 2.3e-16. PPE7,member of the Mycobacterium tuberculosis PPE family,similar to others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa), FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa overlap). Possible continuation of ORF upstream, but no sequence error apparent. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis, a 2 bp insertion (*-ta) resulting in the absence of a stop codon between the 2 genes, leads to a single product. Q7U270 No PE/PPE Rv0355c NC_002945.3 Mycobrowser_v2 CDS 443412 444095 . + 0 Mb0371 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0371, -, len: 227 aa. Equivalent to Rv0364, len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 227 aa overlap). Possible conserved transmembrane protein, equivalent to O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLCB 4_19 HYPOTHETICAL 24.3 KDA PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1% identity in 227 aa overlap). Shows strong similarity to DEDA_ECOLI|P09548 DedA PROTEIN protein from Escherichia coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa overlap). Similar also to Mycobacterium tuberculosis DedA protein Rv2637|MTCY441.0. Q7U263 No cell wall and cell processes Rv0364 NC_002945.3 Mycobrowser_v2 CDS 1015332 1015766 . + 0 Mb0934 CONSERVED HYPOTHETICAL PROTEIN Mb0934, -, len: 144 aa. Equivalent to Rv0910, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved hypothetical protein, equivalent to NP_302398.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa),FASTA scores: opt: 820, E(): 0, (83.9% identity in 143 aa overlap). Also similar to Rv1546|MTCY48.19c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (143 aa). Q7U119 No conserved hypotheticals Rv0910 NC_002945.3 Mycobrowser_v2 CDS 436488 437786 . - 0 Mb0364c purA PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE) Mb0364c, purA, len: 432 aa. Equivalent to Rv0357c,len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Probable purA,adenylosuccinate synthase (EC 6.3.4.4), equivalent to AL023514|MLCB4_13 from ADENYLOSUCCINATE SYNTHETASE Mycobacterium leprae (432 aa), FASTA scores: opt: 2555,E(): 0, (87.9% identity in 431 aa overlap). Also highly similar to many bacterial adenylosuccinates synthetases e.g. P12283|PURA_ECOLI adenylosuccinates synthetase from Escherichia coli (431 aa), FASTA scores: E(): 0, (51.1% identity in 425 aa overlap); etc. BELONGS TO THE ADENYLOSUCCINATE SYNTHETASE FAMILY. X2BET8,P65881 No NC_002945.3 Mycobrowser_v2 CDS 437877 438524 . + 0 Mb0365 conserved protein Mb0365, -, len: 215 aa. Equivalent to Rv0358, len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Conserved hypothetical protein, highly similar to AL023514|MLCB4_14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 852, E(): 0, (62.9% identity in 229 aa overlap). Q7U268 No conserved hypotheticals Rv0358 NC_002945.3 Mycobrowser_v2 CDS 438535 439314 . + 0 Mb0366 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0366, -, len: 259 aa. Equivalent to Rv0359, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 259 aa overlap). Probable conserved integral membrane protein, highly similar to hypothetical or other membrane proteins e.g. AL133220|SCC75A_6|T50569 probable membrane protein from Streptomyces coelicolor (265 aa), FASTA scores: opt: 642, E(): 0, (43.1% identity in 248 aa overlap); P70995 HYPOTHETICAL 24.7 KD PROTEIN from Bacillus subtilis (219 aa), FASTA scores: E(): 1.5e-12, (31.3% identity in 192 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142). Q7U267 No cell wall and cell processes Rv0359 NC_002945.3 Mycobrowser_v2 CDS 439319 439756 . - 0 Mb0367c conserved protein Mb0367c, -, len: 145 aa. Equivalent to Rv0360c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c hypothetical protein from Mycobacterium leprae (137 aa),FASTA scores: opt: 793, E(): 0, (85.4% identity in 137 aa overlap). And similar to AL049754|SCH10_25c|T36537 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity in 138 aa overlap). Q7U266 No conserved hypotheticals Rv0360c NC_002945.3 Mycobrowser_v2 CDS 439839 440666 . + 0 Mb0368 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0368, -, len: 275 aa. Equivalent to Rv0361, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable conserved membrane protein (has hydrophobic stretch from residues 132-156), equivalent to AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane protein from Mycobacterium leprae (292 aa), FASTA scores: opt: 1044, E(): 0, (58.6% identity in 292 aa overlap). Q7U265 No cell wall and cell processes Rv0361 NC_002945.3 Mycobrowser_v2 CDS 1021810 1022109 . - 0 Mb0940c PE7 pe family protein pe7 Mb0940c, PE7, len: 99 aa. Equivalent to Rv0916c,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many e.g. Rv1788 from Mycobacterium tuberculosis (99 aa), FASTA scores: opt: 321, E(): 1.3e-11, (53.5% identity in 99 aa overlap); etc. Q7U113 No PE/PPE Rv0916c NC_002945.3 Mycobrowser_v2 CDS 440888 442270 . + 0 Mb0369 mgtE POSSIBLE Mg2+ TRANSPORT TRANSMEMBRANE PROTEIN MGTE Mb0369, mgtE, len: 460 aa. Equivalent to Rv0362,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 460 aa overlap). Possible mgtE,magnesium (Mg2+) transport transmembrane protein; C-terminal region is highly similar to MGTE|G780283 putative Mg2+ transporter from Providencia stuarti (314 aa), FASTA scores: E(): 0, (47.2% identity in 307 aa overlap) (N-terminus extends approx. 150 aa further upstream compared to P. stuarti ORF). Also similar in part to others e.g. AAK20879.1|AF334760_1|AF334760 putative Mg2+ transporter from Aeromonas hydrophila (455 aa); NP_231292.1|NC_002505 magnesium transporter from Vibrio cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport protein from Mesorhizobium loti (454 aa); etc. Also similar to Rv1232c|MTV006.04c from Mycobacterium tuberculosis (435 aa). Extended hydrophobic segment spanning last 130 residues. BELONG TO THE MGTE FAMILY. Q7U264 No cell wall and cell processes Rv0362 NC_002945.3 Mycobrowser_v2 CDS 442282 443316 . - 0 Mb0370c fba PROBABLE FRUCTOSE-BISPHOSPHATE ALDOLASE FBA Mb0370c, fba, len: 344 aa. Equivalent to Rv0363c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable fba (alternate gene name: fda), fructose bisphosphate aldolase (EC 4.1.2.13), equivalent to AL023514|MLCB4_18|O69600|ALF_MYCLE FRUCTOSE-BISPHOSPHATE ALDOLASE from Mycobacterium leprae (345 aa), FASTA scores: opt: 1995, E(): 0, (87.7% identity in 342 aa overlap). Also highly similar to others. BELONGS TO CLASS II FRUCTOSE-BISPHOSPHATE ALDOLASE FAMILY. COFACTOR: ZINC. X2BEQ4,P67476 No NC_002945.3 Mycobrowser_v2 CDS 705720 705917 . - 0 Mb0626A HYPOTHETICAL PROTEIN Mb0626A, -, len:65 aa. Equivelent to a conserved protein of unknown function YP_007259328 from Mycobacterium canettii strain CIPT 140060008 (99% with 64 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb0626A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BFI6 No NC_002945.3 Mycobrowser_v2 CDS 444084 445214 . - 0 Mb0372c conserved protein Mb0372c, -, len: 376 aa. Equivalent to Rv0365c,len: 376 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 376 aa overlap). Conserved hypothetical protein, very similar to G388212|CAA35191.1, a truncated ORF immediately upstream of the Corynebacterium glutamicum fda gene encoding fructose-1,6-biphosphate aldolase (304 aa), FASTA scores: E(): 7.1e-19, (42.2% identity in 296 aa overlap). Q7U262 No conserved hypotheticals Rv0365c NC_002945.3 Mycobrowser_v2 CDS 1208743 1209009 . + 0 Mb1112 CONSERVED HYPOTHETICAL PROTEIN Mb1112, -, len: 88 aa. Equivalent to Rv1083, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 88 aa overlap). Conserved hypothetical protein, similar to U15183|MLU15183_9 hypothetical protein from Mycobacterium leprae (167 aa), FASTA scores: opt: 332, E(): 1.2e-13, (58.4% identity in 101 aa overlap). Hydrophobic domain aa 25-43. Q7U0Q0 No conserved hypotheticals Rv1083 NC_002945.3 Mycobrowser_v2 CDS 445239 445832 . - 0 Mb0373c CONSERVED HYPOTHETICAL PROTEIN Mb0373c, -, len: 197 aa. Equivalent to Rv0366c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Conserved hypothetical protein, showing weak similarity to HI1395|P44173|YD95_HAEIN HYPOTHETICAL PROTEIN from Haemophilus influenzae (140 aa), FASTA scores: opt: 152,E(): 0.0015, (27.0% identity in 126 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 Glycine radical signature. Q7U261 No conserved hypotheticals Rv0366c NC_002945.3 Mycobrowser_v2 CDS 446331 447542 . - 0 Mb0375c CONSERVED HYPOTHETICAL PROTEIN Mb0375c, -, len: 403 aa. Equivalent to Rv0368c,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 403 aa overlap). Conserved hypothetical protein, showing some similarity to AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium japonicum (422 aa),FASTA scores: opt: 341, E(): 4.3e-13, (27.4% identity in 387 aa overlap); Rv2425c|MTCY428_22 hypothetical protein from Mycobacterium tuberculosis FASTA score: (30.7% identity in 238 aa overlap). Contains PS00213 Lipocalin signature. Q7U259 No conserved hypotheticals Rv0368c NC_002945.3 Mycobrowser_v2 CDS 447548 448063 . - 0 Mb0376c POSSIBLE MEMBRANE OXIDOREDUCTASE Mb0376c, -, len: 171 aa. Equivalent to Rv0369c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Possible membrane protein oxidoreductase (EC 1.-.-.-), similar to ORF 4 of the Pseudomonas thermocarboxydovorans protein of cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from Pseudomonas thermocarboxydovorans (171 aa), FASTA scores: opt: 226, E(): 9.8e-08, (31.3% identity in 166 aa overlap). Also similar to MTV036.05, MTV036.08, MTV036.09,and MTV026.10. Q7U258 No intermediary metabolism and respiration Rv0369c NC_002945.3 Mycobrowser_v2 CDS 448164 449060 . - 0 Mb0377c POSSIBLE OXIDOREDUCTASE Mb0377c, -, len: 298 aa. Equivalent to Rv0370c,len: 298 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 298 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many hypothetical proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL gene cluster from Pseudomonas/Oligotropha carboxidovorans (295 aa), FASTA scores: opt: 851, E(): 0, (48.2% identity in 282 aa overlap); AJ224684|BJAJ4684_3 cooxS from Bradyrhizobium japonicum (302 aa), FASTA scores: opt: 881, E(): 0, (47.6% identity in 290 aa overlap). Also highly similar to MTCY428_21 from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U257 No intermediary metabolism and respiration Rv0370c NC_002945.3 Mycobrowser_v2 CDS 477413 477661 . + 0 Mb0403A Conserved protein Mb0403A, len: 82 aa. Equivalent to Rv0397A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BEX9 No conserved hypotheticals Rv0397A NC_002945.3 Mycobrowser_v2 CDS 449057 449650 . - 0 Mb0378c CONSERVED HYPOTHETICAL PROTEIN Mb0378c, -, len: 197 aa. Equivalent to Rv0371c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 247, E(): 4.5e-09, (32.3% identity in 195 aa overlap). Also weak similarity with YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE from Bacillus subtilis (197 aa), FASTA scores: opt: 217,E(): 2.5e-08, (27.0% identity in 174 aa overlap). Q7U256 No conserved hypotheticals Rv0371c NC_002945.3 Mycobrowser_v2 CDS 449647 450402 . - 0 Mb0379c CONSERVED HYPOTHETICAL PROTEIN Mb0379c, -, len: 251 aa. Equivalent to Rv0372c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Conserved hypothetical protein, showing some similarity with CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1% identity in 95 aa overlap). Also similar to upstream ORF Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap). Q7U255 No conserved hypotheticals Rv0372c NC_002945.3 Mycobrowser_v2 CDS 480808 481179 . + 0 Mb0407 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0407, -, len: 123 aa. Equivalent to Rv0401, len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 123 aa overlap). Probable conserved transmembrane protein, equivalent to AL023514|MLCB4_9 putative integral membrane protein from Mycobacterium leprae (122 aa), FASTA scores: opt: 548, E(): 4.4e-32,(66.9% identity in 121 aa overlap). Q7U229 No cell wall and cell processes Rv0401 NC_002945.3 Mycobrowser_v2 CDS 450421 452820 . - 0 Mb0380c PROBABLE CARBON MONOXYDE DEHYDROGENASE (LARGE CHAIN) Mb0380c, -, len: 799 aa. Equivalent to Rv0373c,len: 799 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 799 aa overlap). Probable carbon monoxide dehydrogenase, large chain (EC 1.2.99.2), highly similar to others e.g. AAD00363.1| U80806|CUTL carbon monoxide dehydrogenase large subunit CutL protein from Hydrogenophaga pseudoflava (803 aa); S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cut operon) from Pseudomonas thermocarboxydovorans (842 aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cluster coxMSL) from Pseudomonas/Oligotropha carboxydovorans (809 aa), FASTA scores: opt: 2484, E(): 0,(56.0% identity in 804 aa overlap); etc. Q7U254 No intermediary metabolism and respiration Rv0373c NC_002945.3 Mycobrowser_v2 CDS 452817 453296 . - 0 Mb0381c PROBABLE CARBON MONOXYDE DEHYDROGENASE (SMALL CHAIN) Mb0381c, -, len: 159 aa. Equivalent to Rv0374c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable carbon monoxide dehydrogenase, small chain (EC 1.2.99.2), highly similar to others e.g. B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA scores: opt: 662, E(): 0, (59.3% identity in 150 aa overlap); CAA12063.1|AJ224684 putative carbon monoxide dehydrogenase small subunit from Bradyrhizobium japonicum (161 aa); S49123|509390|CAA54901.1|X77931|CUTC carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (163 aa); etc. Q7U253 No intermediary metabolism and respiration Rv0374c NC_002945.3 Mycobrowser_v2 CDS 457285 457836 . - 0 Mb0387c POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE) Mb0387c, -, len: 183 aa. Equivalent to Rv0380c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Possible RNA methyltransferase (EC 2.1.1.-), equivalent to CAC32002.1|AL583925 possible RNA methyltransferase from Mycobacterium leprae (182 aa). Also some similarity with others methyltransferases e.g. P19396|TRMH_ECOLI|78514|JV0043 TRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa overlap). Also similar to Rv0881, Rv3579c, Rv1644 from Mycobacterium tuberculosis. Q7U247 No intermediary metabolism and respiration Rv0380c NC_002945.3 Mycobrowser_v2 CDS 453311 454171 . - 0 Mb0382c PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM CHAIN) Mb0382c, -, len: 286 aa. Equivalent to Rv0375c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable carbon monoxide dehydrogenase, medium chain (EC 1.2.99.2),similar to others e.g. AAD00361.1|U80806|CUTM carbon monoxide dehydrogenase middle subunit from Hydrogenophaga pseudoflava (287 aa); S49122|509389|CAA54900.1|X77931|CUTB carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (287 aa); A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (288 aa),FASTA scores: opt: 594, E(): 0, (37.5% identity in 277 aa overlap); etc. Q7U252 No intermediary metabolism and respiration Rv0375c NC_002945.3 Mycobrowser_v2 CDS 454247 455389 . - 0 Mb0383c CONSERVED HYPOTHETICAL PROTEIN Mb0383c, -, len: 380 aa. Equivalent to Rv0376c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 380 aa overlap). Conserved hypothetical protein, highly similar to T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical protein from Streptomyces coelicolor (395 aa); and AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from Arthrobacter nicotinovorans (377 aa). And similar to other conserved hypothetical proteins e.g. NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical protein from Mesorhizobium loti (245 aa). Note that C-terminus shows similarity with C-termini of CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); CAB76250.1|X82447|COXI CoxI protein from Pseudomonas/Oligotropha carboxidovorans (330 aa); and AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in 138 aa overlap). Also some partial similarity with AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3% identity in 92 aa overlap); E1184330|Z99120|YURF YURF PROTEIN from Bacillus subtilis (330 aa), FASTA scores: opt: 170, E(): 2.9e- 16, (27.5% identity in 345 aa overlap). Also similar to downstream ORF Rv0372c from Mycobacterium tuberculosis (251 aa), FASTA scores: E(): 2.1e-06, (30.7% identity in 277 aa overlap). Q7U251 No conserved hypotheticals Rv0376c NC_002945.3 Mycobrowser_v2 CDS 455438 456403 . + 0 Mb0384 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LYSR-FAMILY) Mb0384, -, len: 321 aa. Equivalent to Rv0377, len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 321 aa overlap). Probable transcription regulator, lysR family, showing similarity with many hypothetical transcriptional regulators lysR homolog e.g. P32484|YEIE_ECOLI|M89774 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli (293 aa), FASTA scores: opt: 265, E(): 4.9e-11, (28.6% identity in 266 aa overlap). Also similar to Rv2282c from Mycobacterium tuberculosis. Contains PS00044 bacterial regulatory protein lysR family signature. SEEMS TO BELONG TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U250 No regulatory proteins Rv0377 NC_002945.3 Mycobrowser_v2 CDS 456654 456875 . + 0 Mb0385 CONSERVED HYPOTHETICAL GLYCINE RICH PROTEIN Mb0385, -, len: 73 aa. Equivalent to Rv0378, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical gly-rich protein, showing some similarity to M. tuberculosis PE_PGRS family; also similar to MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD protein (1011 aa), FASTA scores: opt: 237, E(): 0.0032,(58.7% identity in 63 aa overlap); MTV043_25. Q7U249 No conserved hypotheticals Rv0378 NC_002945.3 Mycobrowser_v2 CDS 456994 457209 . + 0 Mb0386 secE2 POSSIBLE PROTEIN TRANSPORT PROTEIN SECE2 Mb0386, secE2, len: 71 aa. Equivalent to Rv0379,len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Possible secE2,protein transport protein, showing similarity with P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: 79, E(): 4.7. (30.3% identity in 66 aa overlap); and hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (71 aa); etc. Also highly similar to U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis protein from a patient isolate (116 aa), FASTA scores: opt: 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). Note that for Rv0379|MTV036.14, a translation initiation region different to the one in U85467|MTU85467_1 was chosen. COULD BE A PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c,SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Q7U248 No cell wall and cell processes Rv0379 NC_002945.3 Mycobrowser_v2 CDS 458858 459397 . - 0 Mb0389c pyrE PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) Mb0389c, pyrE, len: 179 aa. Equivalent to Rv0382c,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable pyrE,orotate phosphoribosyltransferase (EC 2.4.2.10),equivalent to CAC32004.1|AL583925 probable purine/pyrimidine phosphoribosyltransferase from Mycobacterium leprae (179 aa). Also highly similar to many others e.g. T36540|4753874|CAB42037.1|AL049754|SCH10.28c probable orotate phosphoribosyltransferase from Streptomyces coelicolor (182 aa); H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable orotate phosphoribosyltransferase from Methanobacterium thermoautotrophicum (180 aa), FASTA scores: opt: 389, E(): 2.7e-20, (40.7% identity in 172 aa overlap); O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 OROTATE PHOSPHORIBOSYLTRANSFERASE from Sulfolobus acidocaldarius (197 aa); etc. Note that also similar to other puridine 5'-monophosphate synthases (umpA genes; UMP synthases),generally in N-terminus that corresponds to orotate phosphoribosyltransferase activity. Contains PS00589 PTS HPR component serine phosphorylation site signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. Note that previously known as umpA. X2BEW3,P0A5U1 No NC_002945.3 Mycobrowser_v2 CDS 459478 460332 . - 0 Mb0390c POSSIBLE CONSERVED SECRETED PROTEIN Mb0390c, -, len: 284 aa. Equivalent to Rv0383c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Possible conserved secreted protein, with hydrophobic stretch in N-terminus and Pro-rich C-terminus. Equivalent to CAC32006.1|AL583925 possible secreted protein from Mycobacterium leprae (286 aa). Q7U245 No cell wall and cell processes Rv0383c NC_002945.3 Mycobrowser_v2 CDS 460473 463019 . - 0 Mb0391c clpB PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1) Mb0391c, clpB, len: 848 aa. Equivalent to Rv0384c,len: 848 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 848 aa overlap). Probable clpB (alternate gene name: htpM), endopeptidase ATP-binding protein, chain B (EC 3.-.-.-), equivalent to AC32007.1|AL583925 heat shock protein from Mycobacterium leprae (848 aa). Also highly similar to others e.g. P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB PROTEIN (heat-inducible expression) from Corynebacterium glutamicum (852 aa), FASTA scores: opt: 4113, E(): 0, (74.5% identity in 846 aa overlap); T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c probable ATP-dependent proteinase ATP-binding chain from Streptomyces coelicolor (853 aa); P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains K12 and O157:H7 (857 aa); etc. Also similar to Rv3596c|ClpC from Mycobacterium tuberculosis. Contains PS00870 and PS00871 Chaperonins clpA/B signatures and two PS000017 ATP/GTP-binding site motives A (P-loop). BELONGS TO THE CLPA/CLPB FAMILY. Contains probable coiled-coil domain from aa 411-503. X2BEW5,P63287 No NC_002945.3 Mycobrowser_v2 CDS 503186 503392 . + 0 Mb0424 thiS POSSIBLE PROTEIN THIS Mb0424, thiS, len: 68 aa. Equivalent to Rv0416,len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Possible thiS protein,equivalent to T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 hypothetical protein from Mycobacterium leprae (74 aa),FASTA scores: opt: 303, E(): 2e-18, (71.6% identity in 74 aa overlap). Shows weak similarity with O32583|THIS_ECOLI|THIG1|B3991.1 THIS PROTEIN from Escherichia coli strain K12 (66 aa), FASTA scores: opt: 103, E(): 0.052, (30.9% identity in 68 aa overlap). Q7U216 No intermediary metabolism and respiration Rv0416 NC_002945.3 Mycobrowser_v2 CDS 463152 464324 . + 0 Mb0392 PROBABLE MONOOXYGENASE Mb0392, -, len: 390 aa. Equivalent to Rv0385, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Probable monooxygenase (EC 1.-.-.-), similar to T37003|5738846|CAB52917.1|AL109949 probable flavohemoprotein from Streptomyces coelicolor (435 aa); and similar in part (C-termini) to various monooxygenases e.g. P19734|DMPP_PSESP|94993|F37831 PHENOL HYDROXYLASE P5 PROTEIN (PHENOL 2-MONOOXYGENASE P5 COMPONENT) (EC 1.14.13.7) from Pseudomonas putida (353 aa), FASTA scores: opt: 363, E(): 4.2e-16, (31.8% identity in 255 aa overlap); S47292|2120861|pir|S70085 phenol 2-monooxygenase (EC 1.14.13.7) chain mopP from Acinetobacter calcoaceticus (350 aa); P21394|XYLA_PSEPU|94933|B37316 XYLENE MONOOXYGENASE ELECTRON TRANSFER COMPONENT (EC 1.18.1.3) [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE] from Pseudomonas putida plasmid pWW0 (350 aa); AAC38360.1|AF043544|NtnMA|ntnA reductase component of 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 aa); etc. Q7U244 No intermediary metabolism and respiration Rv0385 NC_002945.3 Mycobrowser_v2 CDS 467689 469020 . - 0 Mb0394c PPE9 conserved hypothetical protein Mb0394c, PPE9, len: 443 aa. Equivalent to Rv0388c and Rv0387c, len: 180 aa and 244 aa, from Mycobacterium tuberculosis strain H37Rv, (95.1% identity in 164 aa overlap and 100.0% identity in 244 aa overlap). Rv0388c: Member of the Mycobacterium tuberculosis PPE family,highly similar to others e.g. MTCY10G2_10|Z92539 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 667, E(): 0, (58.3% identity in 180 aa overlap) but much shorter. Rv0387c: conserved hypothetical protein, showing some similarity to MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon 1, Elastin (687 aa), FASTA scores: opt: 193, E(): 0.35, (34.4% identity in 189 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (tctacagt-gctacagg), and lastly of 28 bases, leads to a longer single product. Q7U242 No PE/PPE Rv0388c NC_002945.3 Mycobrowser_v2 CDS 469354 470613 . + 0 Mb0395 purT PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) (FORMATE-DEPENDENT GAR TRANSFORMYLASE) Mb0395, purT, len: 419 aa. Equivalent to Rv0389,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 419 aa overlap). Probable purT,phosphoribosylglycinamide formyltransferase 2 (EC 2.1.2.-), similar to others e.g. P33221|PURT_ECOLI|B1849 phosphoribosylglycinamide formyltransferase 2 from Escherichia coli strain K-12 (391 aa), FASTA scores: opt: 481, E(): 1.3e-22, (40.1% identity in 379 aa overlap); etc. BELONGS TO THE PURK / PURT FAMILY. COFACTOR: MAGNESIUM. Q7U241 No intermediary metabolism and respiration Rv0389 NC_002945.3 Mycobrowser_v2 CDS 470610 471032 . + 0 Mb0396 conserved protein Mb0396, -, len: 140 aa. Equivalent to Rv0390, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein from Mycobacterium leprae (147 aa), FASTA scores: opt: 778, E(): 0, (79.0% identity in 138 aa overlap). Also similar to hypothetical proteins from several Rickettsia species. Q7U240 No conserved hypotheticals Rv0390 NC_002945.3 Mycobrowser_v2 CDS 471029 472249 . + 0 Mb0397 metZ PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ (OSH SULFHYDRYLASE) Mb0397, metZ, len: 406 aa. Equivalent to Rv0391,len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable metZ,O-succinylhomoserine sulfhydrylase (EC 4.2.99.-),equivalent, but shorter 20 aa in N-terminus, to AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from Mycobacterium leprae (426 aa). Also highly similar to others e.g. METZ_PSEAE|P55218 o-succinylhomoserine sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA scores: opt: 1175, E(): 0, (47.2% identity in 392 aa overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. Could also be a cystathionine gamma-synthase (EC 4.2.99.9). Q7U239 No intermediary metabolism and respiration Rv0391 NC_002945.3 Mycobrowser_v2 CDS 472246 473658 . - 0 Mb0398c ndhA PROBABLE MEMBRANE NADH DEHYDROGENASE NDHA Mb0398c, ndhA, len: 470 aa. Equivalent to Rv0392c,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 470 aa overlap). Probable ndhA,membrane NADH dehydrogenase (EC 1.6.99.3), equivalent to many e.g. AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium smegmatis (457 aa), FASTA scores: opt: 1991,E(): 0, (67.9% identity in 458 aa overlap); MLCB1788_3 NADH dehydrogenase from Mycobacterium leprae (466 aa),FASTA score: (62.5% identity in 467 aa overlap). Also similar to others from several organisms e.g. P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH DEHYDROGENASE from Escherichia coli (434 aa); and Rv0392c|ndhB from Mycobacterium tuberculosis. Has hydrophobic stretch in C-terminus. BELONGS TO THE NADH DEHYDROGENASE FAMILY. Q7U238 No NC_002945.3 Mycobrowser_v2 CDS 473800 475125 . + 0 Mb0399 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0399, -, len: 441. Equivalent to Rv0393, len: 441 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 441 aa overlap). Member of Mycobacterium tuberculosis 13E12 repeat family of conserved proteins,similar to many e.g. Rv1148c, Rv1945, Rv3467,Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0, (61.1% identity in 347 aa overlap). Q7U237 No insertion seqs and phages Rv0393 NC_002945.3 Mycobrowser_v2 CDS 475141 475860 . - 0 Mb0400c POSSIBLE SECRETED PROTEIN Mb0400c, -, len: 239 aa. Equivalent to Rv0394c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible secreted protein, sharing no homology with other proteins. Has hydrophobic stretch at its N-terminus. Q7U236 No cell wall and cell processes Rv0394c NC_002945.3 Mycobrowser_v2 CDS 475959 476363 . + 0 Mb0401 HYPOTHETICAL PROTEIN Mb0401, -, len: 134 aa. Equivalent to Rv0395, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Hypothetical unknown protein. Q7U235 No conserved hypotheticals Rv0395 NC_002945.3 Mycobrowser_v2 CDS 476369 476761 . + 0 Mb0402 HYPOTHETICAL PROTEIN Mb0402, -, len: 130 aa. Equivalent to Rv0396, len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Hypothetical unknown protein. Q7U234 No conserved hypotheticals Rv0396 NC_002945.3 Mycobrowser_v2 CDS 476835 477203 . + 0 Mb0403 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0403, -, len: 122 aa. Equivalent to Rv0397, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Part of 13E12 repeat family of conserved Mycobacterium tuberculosis proteins,similar to downstream Rv0393|Z84725|MTCY4D9_5 CONSERVED 13E12 REPEAT FAMILY PROTEIN (441 aa), FASTA scores: E(): 0, (87.7% identity in 122 aa overlap). Q7U233 No insertion seqs and phages Rv0397 NC_002945.3 Mycobrowser_v2 CDS 478346 479575 . - 0 Mb0405c lpqK POSSIBLE CONSERVED LIPOPROTEIN LPQK Mb0405c, lpqK, len: 409 aa. Equivalent to Rv0399c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Possible lpqK,conserved lipoprotein, showing some similarity to penicillin binding proteins and various peptidases e.g. DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase protein (406 aa), FASTA scores: opt: 348, E(): 5.6e-16,(29.2% identity in 301 aa overlap). Also similar to other Mycobacterium tuberculosis PBPs and esterases. Has possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Q7U231 No NC_002945.3 Mycobrowser_v2 CDS 479585 480772 . - 0 Mb0406c fadE7 acyl-coa dehydrogenase fade7 Mb0406c, fadE7, len: 395 aa. Equivalent to Rv0400c,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 395 aa overlap). Probable fadE7,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. CAC12923.1|AL445403 putative acyl CoA dehydrogenase from Streptomyces coelicolor (397 aa); G624219 GLUTARYL-COA DEHYDROGENASE PRECURSOR (438 aa), FASTA scores: opt: 1161,E(): 0, (48.1% identity in 391 aa overlap); etc. Q7U230 No NC_002945.3 Mycobrowser_v2 CDS 481374 482477 . - 0 Mb0408c mmpL1b PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL1B [SECOND PART] Mb0408c, mmpL1b, len: 367 aa. Equivalent to 3' end of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 367 aa overlap). Probable mmpL1, conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kd membrane protein from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0, (55.4% identity in 933aa overlap); YV34_MYCLE|P54881 hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3615,E(): 0, (55.5% identity in 941 aa overlap); etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and M. leprae e.g. Rv0450c,Rv0676c, Rv0507, etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b. Q7U228 No NC_002945.3 Mycobrowser_v2 CDS 482474 484249 . - 0 Mb0409c mmpL1a PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL1A [FIRST PART] Mb0409c, mmpL1a, len: 591 aa. Equivalent to 5' end of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 568 aa overlap). Probable mmpL1, conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kd membrane protein from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0,(55.4% identity in 933aa overlap); YV34_MYCLE|P54881 hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3615, E(): 0, (55.5% identity in 941 aa overlap); etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and M. leprae e.g. Rv0450c, Rv0676c, Rv0507,etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b. Q7U227 No NC_002945.3 Mycobrowser_v2 CDS 484246 484674 . - 0 Mb0410c mmpS1 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS1 Mb0410c, mmpS1, len: 142 aa. Equivalent to Rv0403c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable mmpS1,conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. YV33_MYCLE|P54880 hypothetical 16.9 kd protein from Mycobacterium leprae (154 aa), FASTA scores: opt: 458,E(): 1.6e-26, (46.9% identity in 143 aa overlap); YV33_MYCTU|Q11170 hypothetical 15 .9 kd protein from M. tuberculosis (147 aa), FASTA scores: opt: 362, E(): 1.1e-19, (42.1% identity in 140 aa overlap); etc. Also similar to other MmpS proteins from Mycobacterium tuberculosis e.g. Rv0677c, Rv0451c, etc. BELONGS TO THE MMPS FAMILY. X2BEY5,P0A5K1 No NC_002945.3 Mycobrowser_v2 CDS 484995 486752 . + 0 Mb0411 fadD30 fatty-acid-amp ligase fadd30 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb0411, fadD30, len: 585 aa. Equivalent to Rv0404,len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 585 aa overlap). Probable fadD30,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa); MASC_MYCLE|P54200 masc protein from Mycobacterium leprae (372 aa), FASTA scores: opt: 888, E(): 0, (44.2% identity in 342 aa overlap). Also similar to Y06J_MYCTU|Q10976 hypothetical 67.9 kd protein (626 aa), FASTA scores: opt: 1463, E(): 0, (42.4% identity in 568 aa overlap). X2BEY1,Q7U226 No NC_002945.3 Mycobrowser_v2 CDS 486749 488131 . + 0 Mb0412 pks6a PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6A [FIRST PART] Mb0412, pks6a, len: 460 aa. Equivalent to 5' end of Rv0405, len: 1402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 456 aa overlap). Probable pks6, membrane-bound polyketide synthase, highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa),FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g) splits pks6 into 2 parts, pks6a and pks6b. Q7U225 No NC_002945.3 Mycobrowser_v2 CDS 488118 490958 . + 0 Mb0413 pks6b PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6B [SECOND PART] Mb0413, pks6b, len: 946 aa. Equivalent to 3' end of Rv0405, len: 1402 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 945 aa overlap). Probable pks6, membrane-bound polyketide synthase, highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa),FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g), splits pks6 into 2 parts, pks6a and pks6b. Q7U224 No NC_002945.3 Mycobrowser_v2 CDS 490906 491724 . - 0 Mb0414c BETA LACTAMASE LIKE PROTEIN Mb0414c, -, len: 272 aa. Equivalent to Rv0406c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Beta-lactamase-like protein, equivalent to AAD38170.1|AF152397_1 beta-lactamase-like protein from Mycobacterium phlei (243 aa); AL023514|MLCB4_8 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1284,E(): 0, (74.9% identity in 243 aa overlap); and AAD38164.1|AF152394_2 beta-lactamase-like protein from Mycobacterium avium (247 aa), FASTA scores: opt: 1301,E(): 0, (74.2% identity in 244 aa overlap); etc. Also slight similarity to others beta-lactamases and hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349 METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa),FASTA scores: (34.4% identity in 96 aa overlap). Q7U223 No conserved hypotheticals Rv0406c NC_002945.3 Mycobrowser_v2 CDS 491802 492812 . + 0 Mb0415 fgd1 f420-dependent glucose-6-phosphate dehydrogenase fgd1 Mb0415, fgd1, len: 336 aa. Equivalent to Rv0407,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable fgd1,F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), equivalent to others from Mycobacteria e.g. AAD38165.1|AF152394_3 from M. avium (336 aa), FASTA scores: opt: 2082, E(): 0, (89.9% identity in 336 aa overlap); AL023514|MLCB 4_7 from Mycobacterium leprae (336 aa), FASTA scores: opt: 2069, E(): 0, (89.0% identity in 336 aa overlap). Also similar to other dehydrogenases e.g. CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase from Methanofollis liminatans (330 aa). Also similar to many proteins from Mycobacterium tuberculosis e.g. Rv0953c, Rv0791c, etc. Note that previously known as fgd. Q7U222 No intermediary metabolism and respiration Rv0407 NC_002945.3 Mycobrowser_v2 CDS 492805 494877 . + 0 Mb0416 pta PROBABLE PHOSPHATE ACETYLTRANSFERASE PTA (PHOSPHOTRANSACETYLASE) Mb0416, pta, len: 690 aa. Equivalent to Rv0408,len: 690 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 690 aa overlap). Probable pta,phosphate acetyltransferase (EC 2.3.1.8), highly similar to others e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 phosphate acetyltransferase from Escherichia coli strain K12 (713 aa), FASTA scores: opt: 1303, E(): 0, (38.0% identity in 718 aa overlap); etc. BELONGS TO THE PHOSPHATE ACETYLTRANSFERASE AND BUTYRYLTRANSFERASE FAMILY. Q7U221 No intermediary metabolism and respiration Rv0408 NC_002945.3 Mycobrowser_v2 CDS 494870 496027 . + 0 Mb0417 ackA PROBABLE ACETATE KINASE ACKA (ACETOKINASE) Mb0417, ackA, len: 385 aa. Equivalent to Rv0409,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Probable ackA,acetate kinase (EC 2.7.2.1), highly similar to others e.g. ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis (395 aa), FASTA scores: opt: 974, E(): 0, (43.5% identity in 393 aa overlap); etc. Contains PS01075 Acetate and butyrate kinases family signature 1, PS00758 ArgE / dapE / ACY1/ CPG2 / yscS family signature 1. BELONGS TO THE ACETOKINASE FAMILY. X2BEY2,P63410 No intermediary metabolism and respiration Rv0409 NC_002945.3 Mycobrowser_v2 CDS 521343 522473 . + 0 Mb0441 CONSERVED HYPOTHETICAL PROTEIN Mb0441, -, len: 376 aa. Equivalent to Rv0433, len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. P77213|YBDK_ECOLI hypothetical 41.7 KD protein from Escherichia coli strain K12 (372 aa), FASTA scores: opt: 555, E(): 2e-30, (28.2% identity in 365 aa overlap). X2BF10,P64694 No conserved hypotheticals Rv0433 NC_002945.3 Mycobrowser_v2 CDS 502167 503189 . + 0 Mb0423 thiO POSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO Mb0423, thiO, len: 340 aa. Equivalent to Rv0415,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). Possible thiO,thiamine biosynthesis oxidoreductase (EC 1.-.-.-),equivalent to T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical protein from Mycobacterium leprae (340 aa),FASTA scores: opt: 1867, E(): 0, (82.0% identity in 338 aa overlap). Shows some similarity to other thiO proteins e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see citation below); AAG31046.1|AF264948_8|THIO putative amino acid oxidase flavoprotein ThiO from Erwinia amylovora (349 aa); NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti (333 aa); etc. Q7U217 No intermediary metabolism and respiration Rv0415 NC_002945.3 Mycobrowser_v2 CDS 496081 498333 . - 0 Mb0418c pknG SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G) Mb0418c, pknG, len: 750 aa. Equivalent to Rv0410c,len: 750 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 750 aa overlap). pknG,serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium leprae (767 aa). Also similar to others e.g. AB76890.1|AL159139 putative serine/threonine protein kinase from Streptomyces coelicolor (774 aa); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. X2BEZ4,P65729 No NC_002945.3 Mycobrowser_v2 CDS 498333 499319 . - 0 Mb0419c glnH PROBABLE GLUTAMINE-BINDING LIPOPROTEIN GLNH (GLNBP) Mb0419c, glnH, len: 328 aa. Equivalent to Rv0411c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 328 aa overlap). Probable glnH,glutamine-binding protein, membrane-bound lipoprotein (see citation below), equivalent to AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 glutamine-binding protein homolog from Mycobacterium leprae (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3% identity in 328 aa overlap). Also similar to others e.g. GLNH_BACST|P27676 glutamine-binding protein precursor from Bacillus stearothermophilus (262 aa), FASTA scores: opt: 493, E(): 7.5e-22, (37.8% identity in 193 aa overlap); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 3. Presumed attached to the membrane by a lipid anchor. Q7U220 No NC_002945.3 Mycobrowser_v2 CDS 499319 500638 . - 0 Mb0420c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0420c, -, len: 439 aa. Equivalent to Rv0412c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Possible conserved membrane protein, equivalent to AL035159|MLCB1450_16|T44737 probable membrane protein from Mycobacterium leprae (403 aa), FASTA scores: opt: 2027,E(): 0, (80.4% identity in 403 aa overlap). Also some similarity with CAB71201.1|AL138538 putative secreted protein from Streptomyces coelicolor (429 aa). Q7U219 No cell wall and cell processes Rv0412c NC_002945.3 Mycobrowser_v2 CDS 500732 501385 . + 0 Mb0421 mutT3 POSSIBLE MUTATOR PROTEIN MUTT3 (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE) (8-OXO-DGTPASE) (DGTP PYROPHOSPHOHYDROLASE) Mb0421, mutT3, len: 217 aa. Equivalent to Rv0413,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Possible mutT3,mutator protein (EC 3.6.1.-), showing some similarity with e.g. MUTT_PROVU|P32090 mutator mutt protein from Proteus vulgaris (112 aa), FASTA scores: opt: 151, E(): 0.0008,(40.7% identity in 59 aa overlap). SEEMS TO BELONG TO THE NUDIX HYDROLASE FAMILY. Q7U218 No NC_002945.3 Mycobrowser_v2 CDS 501369 502037 . - 0 Mb0422c thiE thiamine-phosphate pyrophosphorylase thie (tmp pyrophosphorylase) (tmp-ppase) (thiamine-phosphate synthase) Mb0422c, thiE, len: 222 aa. Equivalent to Rv0414c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable thiE,thiamin phosphate pyrophosphorylase (EC 2.5.1.3),equivalent to Q9ZBL5|AL035159|MLCB1450_17 PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE from Mycobacterium leprae (235 aa), FASTA scores: opt: 1095, E(): 0, (78.0% identity in 223 aa overlap). Also similar to others e.g. T34974|5689976|CAB52013.1|AL109663 probable thiamin phosphate pyrophosphorylase from Streptomyces coelicolor (223 aa); THIE_ECOLI|P30137 thie protein from Escherichia coli strain K12 (211 aa), FASTA scores: opt: 275, E(): 7.8e-12, (37.8% identity in 196 aa overlap); etc. BELONGS TO THE TMP-PPASE FAMILY. X2BEY7,P66917 No NC_002945.3 Mycobrowser_v2 CDS 503385 504143 . + 0 Mb0425 thiG PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG (THIAZOLE BIOSYNTHESIS PROTEIN) Mb0425, thiG, len: 252 aa. Equivalent to Rv0417,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 252 aa overlap). Probable thiG, thiamin biosynthesis protein, equivalent to AL035159|MLCB1450_20|T44741|THIG probable thiamin biosynthesis protein from Mycobacterium leprae (261 aa),FASTA scores: opt: 1380, E(): 0, (86.8% identity in 250 aa overlap). Also highly similar to others e.g. SCOEDB|SC6E10.03|T35490|THIG probable thiazole biosynthesis protein from Streptomyces coelicolor (264 aa); F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG thiamin biosynthesis protein thiG from Xylella fastidiosa (275 aa); P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089.1|U00006 THIG PROTEIN thiamin biosynthesis protein from Escherichia coli strain K-12 (281 aa); etc. BELONGS TO THE THIG FAMILY. X2BF00,P59948 No intermediary metabolism and respiration Rv0417 NC_002945.3 Mycobrowser_v2 CDS 504515 506017 . + 0 Mb0426 lpqL PROBABLE LIPOPROTEIN AMINOPEPTIDASE LPQL Mb0426, lpqL, len: 500 aa. Equivalent to Rv0418,len: 500 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 500 aa overlap). Probable lpqL,lipoprotein aminopeptidase (EC 3.4.11.-), similar to others e.g. B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 probable aminopeptidase from Pseudomonas aeruginosa (536 aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase (EC 3.4.11.-) from Streptomyces griseus (284 aa) (homology only with C-terminus of Rv0418); P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y (EC 3.4.11.-) from Saccharomyces cerevisiae (537 aa); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U215 No cell wall and cell processes Rv0418 NC_002945.3 Mycobrowser_v2 CDS 506105 507601 . + 0 Mb0427 lpqM POSSIBLE LIPOPROTEIN PEPTIDASE LPQM Mb0427, lpqM, len: 498 aa. Equivalent to Rv0419,len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 498 aa overlap). Possible lpqM,lipoprotein peptidase (EC 3.4.-.-); has potential N-terminal signal peptide and contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q7U214 No cell wall and cell processes Rv0419 NC_002945.3 Mycobrowser_v2 CDS 507580 507990 . - 0 Mb0428c POSSIBLE TRANSMEMBRANE PROTEIN Mb0428c, -, len: 136 aa. Equivalent to Rv0420c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 136 aa overlap). Possible transmembrane protein; has potential transmembrane domains aa 53-99 and aa 100-122. Q7U213 No cell wall and cell processes Rv0420c NC_002945.3 Mycobrowser_v2 CDS 508151 508780 . - 0 Mb0429c CONSERVED HYPOTHETICAL PROTEIN Mb0429c, -, len: 209 aa. Equivalent to Rv0421c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Conserved hypothetical protein, showing similarity with NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical protein from Mesorhizobium loti (214 aa). Q7U212 No conserved hypotheticals Rv0421c NC_002945.3 Mycobrowser_v2 CDS 517036 517911 . - 0 Mb0435c xthA PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI) Mb0435c, xthA, len: 291 aa. Equivalent to Rv0427c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (EC 3.1.11.2), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. BELONGS TO THE AP/EXOA FAMILY OF DNA REPAIR ENZYMES. Q7U208 No NC_002945.3 Mycobrowser_v2 CDS 508777 509574 . - 0 Mb0430c thiD PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE) Mb0430c, thiD, len: 265 aa. Equivalent to Rv0422c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Probable thiD,phosphomethylpyrimidine kinase (EC 2.7.4.7), equivalent to AL035159|MLCB1450_21 PHOSPHOMETHYLPYRIMIDINE KINASE from Mycobacterium leprae (279 aa), FASTA scores: opt: 1386,E(): 0, (77.8% identity in 266 aa overlap). Also highly similar to others e.g. HIU32725_3|P44697|THID_HAEIN PHOSPHOMETHYLPYRIMIDINE KINASE from Haemophilus influenzae (269 aa), FASTA scores: opt: 605, E(): 0, (42.1% identity in 259 aa overlap). BELONGS TO THE THID FAMILY. X2BF06,P66914 No NC_002945.3 Mycobrowser_v2 CDS 617996 618646 . + 0 Mb0539 POSSIBLE THIOREDOXIN PROTEIN (THIOL-DISULFIDE INTERCHANGE PROTEIN) Mb0539, -, len: 216 aa. Equivalent to Rv0526, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Possible thioredoxin protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q49816|U2168C|S72901 hypothetical protein from Mycobacterium leprae (216 aa), FASTA scores: opt: 1144, E(): 0, (78.5% identity in 214 aa overlap). C-terminus shows some similarity to C-terminus of thioredoxins e.g. RESA_BACSU|P35160 resa protein from Bacillus subtilis (181 aa), FASTA scores: opt: 200, E(): 7.4e-06, (24.2% identity in 132 aa overlap); etc. Also similar to Mycobacterium tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194 Thioredoxin family active site. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY. Q7U1U8 No intermediary metabolism and respiration Rv0526 NC_002945.3 Mycobrowser_v2 CDS 509601 511244 . - 0 Mb0431c thiC PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC Mb0431c, thiC, len: 547 aa. Equivalent to Rv0423c,len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 547 aa overlap). Probable thiC,thiamin biosynthesis protein, equivalent to Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity in 547 aa overlap). Also highly similar to others e.g. P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E(): 0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI THIC PROTEIN from Escherichia coli strain K12 (631 aa),FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa overlap); etc. BELONGS TO THE THIC FAMILY. X2BF01,P66912 No NC_002945.3 Mycobrowser_v2 CDS 511396 511671 . - 0 Mb0432c HYPOTHETICAL PROTEIN Mb0432c, -, len: 91 aa. Equivalent to Rv0424c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Hypothetical unknown protein. Q7U211 No conserved hypotheticals Rv0424c NC_002945.3 Mycobrowser_v2 CDS 511721 516340 . - 0 Mb0433c ctpH POSSIBLE METAL CATION TRANSPORTING P-TYPE ATPASE CTPH Mb0433c, ctpH, len: 1539 aa. Equivalent to Rv0425c,len: 1539 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1539 aa overlap). Possible ctpH,metal cation-transporting P-type ATPase (transmembrane protein) (EC 3.6.1.-), showing some similarity with CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative cation-transporting ATPase from Mycobacterium leprae (1609 aa). Also similar to others ATPases e.g. AE000873_1 CATION-TRANSPORTING P-ATPASE from Methanobacterium thermoautotrop (844 aa), FASTA score: (30.5% identity in 827 aa overlap); AB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); etc. C-terminal region similar to other ATPases from Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative cation-transporting ATPase C (855 aa), FASTA scores: opt: 770, E(): 5.3e-32, (44.9% identity in 820 aa overlap). Q7U210 No NC_002945.3 Mycobrowser_v2 CDS 516392 516835 . - 0 Mb0434c POSSIBLE TRANSMEMBRANE PROTEIN Mb0434c, -, len: 147 aa. Equivalent to Rv0426c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Possible transmembrane protein; has potential transmembrane domains aa 19-41, and aa 61-83. Q7U209 No cell wall and cell processes Rv0426c NC_002945.3 Mycobrowser_v2 CDS 517914 518822 . - 0 Mb0436c gcn5-related n-acetyltransferase Mb0436c, -, len: 302 aa. Equivalent to Rv0428c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Hypothetical unknown protein. Q7U207 No intermediary metabolism and respiration Rv0428c NC_002945.3 Mycobrowser_v2 CDS 518822 519415 . - 0 Mb0437c def PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Mb0437c, def, len: 197 aa. Equivalent to Rv0429c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Probable def,polypeptide deformylase (EC 3.5.1.31), equivalent to CAC30884.1|AL583923 polypeptide deformylase from Mycobacterium leprae (197 aa). Also similar to others e.g. DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from Escherichia coli (169 aa), FASTA scores: opt: 179, E(): 1.8e-05, (34.6% identity in 162 aa overlap); etc. BELONGS TO THE POLYPEPTIDE DEFORMYLASE FAMILY. COFACTOR: BINDS 1 ZINC ION. X2BF02,Q7U206 No NC_002945.3 Mycobrowser_v2 CDS 519752 520060 . + 0 Mb0438 CONSERVED HYPOTHETICAL PROTEIN Mb0438, -, len: 102 aa. Equivalent to Rv0430, len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, equivalent to AC30882.1|AL583923 conserved hypothetical protein from Mycobacterium leprae (102 aa). Also highly similar to CAB93047.1|SCD95A.20|AL357432 hypothetical protein from Streptomyces coelicolor (84 aa). Q7U205 No conserved hypotheticals Rv0430 NC_002945.3 Mycobrowser_v2 CDS 520092 520586 . + 0 Mb0439 PUTATIVE TUBERCULIN RELATED PEPTIDE Mb0439, -, len: 164 aa. Equivalent to Rv0431, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 164 aa overlap). Putative tuberculin related peptide; almost identical to D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis (172 aa), FASTA score: (99.4% identity in 163 aa overlap). Highly similar to to CAC30881.1|AL583923 tuberculin related peptide (AT103) from Mycobacterium leprae (167 aa). Some similarity to G550415|HRPC (282 aa), FASTA scores: opt: 120, E(): 0.36, (33.3% identity in 111 aa overlap). Potential transmembrane domain at aa 19-37. Q7U204 No cell wall and cell processes Rv0431 NC_002945.3 Mycobrowser_v2 CDS 520619 521341 . + 0 Mb0440 sodC periplasmic superoxide dismutase [cu-zn] sodc Mb0440, sodC, len: 240 aa. Equivalent to Rv0432,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable sodC,periplasmic superoxide dismutase [Cu-Zn] (EC 1.15.1.1),equivalent to CAC30880.1|AL583923 superoxide dismutase precursor (Cu-Zn) from Mycobacterium leprae (240 aa); and AAK20038.1|AF326234_1 copper zinc superoxide dismutase from Mycobacterium avium subsp. paratuberculosis (226 aa). Also similar to others e.g. SODC_PHOLE|P00446 superoxide dismutase precursor (cu-zn) from Photobacterium leiognathi (173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5% identity in 181 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. BELONGS TO THE CU-ZN SUPEROXIDE DISMUTASE FAMILY. Possibly localized in periplasm, membrane-bound. X2BF16,P0A609 No virulence, detoxification, adaptation Rv0432 NC_002945.3 Mycobrowser_v2 CDS 623479 623796 . + 0 Mb0544 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0544, -, len: 105 aa. Equivalent to Rv0531, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Possible conserved membrane protein, highly similar to Y13803|MLB1306_1|CAA74131.1 hypothetical protein from Mycobacterium leprae (86 aa), FASTA scores: E(): 2.1e-24,(74.4% identity in 86 aa overlap); and NP_302557.1|NC_002677 putative membrane protein from Mycobacterium leprae (111 aa). Q7U1U3 No cell wall and cell processes Rv0531 NC_002945.3 Mycobrowser_v2 CDS 533415 533930 . + 0 Mb0451 conserved protein Mb0451, -, len: 171 aa. Equivalent to Rv0443, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Conserved hypothetical protein, highly similar to AL049863|SC5H1_23|T35339 hypothetical protein from Streptomyces coelicolor (171 aa), FASTA scores: opt: 561,E(): 2.3e-32, (49.7% identity in 165 aa overlap); and CAC42482.1|AJ318385 hypothetical protein from Amycolatopsis mediterranei (163 aa). Q7U1Z8 No conserved hypotheticals Rv0443 NC_002945.3 Mycobrowser_v2 CDS 522533 523186 . + 0 Mb0442 CONSERVED HYPOTHETICAL PROTEIN Mb0442, -, len: 217 aa. Equivalent to Rv0434, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Conserved hypothetical protein, similar to AE002052_2 from Deinococcus radiodurans (213 aa), FASTA scores: opt: 258, E(): 4e-10,(31.9% identity in 213 aa overlap); SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from Synechocystis (214 aa),FASTA scores: opt: 156, E(): 0.00041, (28.4% identity in 204 aa overlap); MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2 from Myxococcus xanthus (826 aa), FASTA scores: opt: 160, E(): 0.00068, (28.4% identity in 197 aa overlap); etc. Q7U203 No conserved hypotheticals Rv0434 NC_002945.3 Mycobrowser_v2 CDS 1243004 1243327 . + 0 Mb1148 conserved protein Mb1148, -, len: 107 aa. Equivalent to Rv1117, len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 107 aa overlap). Conserved hypothetical protein, some similarity to P94425|D50453 hypothetical protein from Bacillus subtilis (95 aa), fasta scores: opt: 128, E(): 5.1e-06, (28.3% identity in 92 aa overlap); and AL117322|SCF1.02 Streptomyces coelicolor (109 aa), FASTA scores: opt: 437, E(): 1.6e-25, (57.5% identity in 106 aa overlap). Q7U0M0 No conserved hypotheticals Rv1117 NC_002945.3 Mycobrowser_v2 CDS 523366 525552 . - 0 Mb0443c PUTATIVE CONSERVED ATPASE Mb0443c, -, len: 728 aa. Equivalent to Rv0435c,len: 728 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 728 aa overlap). Putative conserved ATPase (EC 3.6.1.-), similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, E(): 0, (34.5% identity in 693 aa overlap); NP_148637.1|7435761|B72479 transitional endoplasmic reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also similar to Rv3610c and Rv2115c from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature. Q7U202 No cell wall and cell processes Rv0435c NC_002945.3 Mycobrowser_v2 CDS 525549 526409 . - 0 Mb0444c pssA PROBABLE CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE PSSA (PS SYNTHASE) (PHOSPHATIDYLSERINE SYNTHASE) Mb0444c, pssA, len: 286 aa. Equivalent to Rv0436c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Probable pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (EC 2.7.8.8) (see citation below), integral membrane protein, equivalent to AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in 285 aa overlap). Also highly similar to others e.g. NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine synthase from Mesorhizobium loti (248 aa); PSS_BACSU|P39823 cdp-diacylglycerol--serine o-phosphatidyltransferase from Bacillus subtilis (177 aa),FASTA scores: opt: 277, E(): 9.9e-12, (33.3% identity in 183 aa overlap); etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. X2BEX8,P59949 No NC_002945.3 Mycobrowser_v2 CDS 526406 527101 . - 0 Mb0445c psd POSSIBLE PHOSPHATIDYLSERINE DECARBOXYLASE PSD (PS DECARBOXYLASE) Mb0445c, psd, len: 231 aa. Equivalent to Rv0437c,len: 231 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 231 aa overlap). Possible psd, phosphatidylserine decarboxylase (EC 4.1.1.65), equivalent to CAC29819.1|AL583918 conserved hypothetical protein from Mycobacterium leprae (243 aa); and highly similar to MLCB1450.11|T44729|4154044|CAA22695.1|AL035159 hypothetical protein from Mycobacterium leprae (202 aa),FASTA score: (74.6% identity in 197 aa overlap). Also similar to other phosphatidylserine decarboxylases e.g. NP_108058.1|14027249|BAB54203.1|AP003012 phosphatidylserine decarboxylase from Mesorhizobium loti (232 aa); AAK86872|g15156090|AGR_C_1963 phosphatidylserine decarboxylase from Agrobacterium tumefaciens (244 aa); AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase from Chlorobium tepidum (216 aa); etc. X2BF21,P67548 No NC_002945.3 Mycobrowser_v2 CDS 534110 534808 . - 0 Mb0452c rska anti-sigma factor rska (regulator of sigma k) Mb0452c, -, len: 232 aa. Equivalent to Rv0444c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 232 aa overlap). Conserved hypothetical protein; C-terminus similar to P12752|Y24K_STRGR HYPOTHETICAL 24.7 KD PROTEIN from Streptomyces griseus (238 aa), FASTA scores: opt: 207, E(): 2.2e-05, (32.9% identity in 158 aa overlap). X2BF17,Q7U1Z7 No information pathways Rv0444c NC_002945.3 Mycobrowser_v2 CDS 527162 528379 . - 0 Mb0446c moeA2 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA2 Mb0446c, moeA2, len: 405 aa. Equivalent to Rv0438c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 405 aa overlap). Probable moeA2,molybdenum cofactor biosynthesis protein, highly similar to many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 aa), FASTA scores: opt: 786, E(): 0, (39.2% identity in 398 aa overlap); etc. Also similar to MOEA1|Rv0994|MTCI237.08|O05577 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (426 aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity in 425 aa overlap). Note that previously known as moeA3. Q7U201 No NC_002945.3 Mycobrowser_v2 CDS 528398 529333 . - 0 Mb0447c probable dehydrogenase/reductase Mb0447c, -, len: 311 aa. Equivalent to Rv0439c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Probable dehydrogenase/reductase (EC 1.-.-.-), equivalent to AL035159|MLCB1450_6|T44727 probable oxidoreductase from Mycobacterium leprae (304 aa), FASTA scores: opt: 1360,E(): 0, (69.2% identity in 302 aa overlap). Also highly similar to various oxidoreductases, generally dehydrogenases/reductases e.g. PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 probable short chain dehydrogenase from Pseudomonas aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE OXIDOREDUCTASE from Streptomyces antibioticus (298 aa),FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in 298 aa overlap); etc. Q7U200 No intermediary metabolism and respiration Rv0439c NC_002945.3 Mycobrowser_v2 CDS 529627 531249 . + 0 Mb0448 groEL2 60 KDA CHAPERONIN 2 GROEL2 (PROTEIN CPN60-2) (GROEL PROTEIN 2) (65 KDA ANTIGEN) (HEAT SHOCK PROTEIN 65) (CELL WALL PROTEIN A) (ANTIGEN A) Mb0448, groEL2, len: 540 aa. Equivalent to Rv0440,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). groEL2 (alternate gene names: groL2, groEL-2, hsp65, hsp60), 60 kDa chaperonin 2 (see first citation below). PURIFIED 65 kDa ANTIGEN CAN ELICIT A STRONG DELAYED-TYPE HYPERSENSITIVITY REACTION IN EXPERIMENTAL ANIMALS INFECTED WITH M. TUBERCULOSIS. THIS PROTEIN IS ONE OF THE MAJOR IMMUNOREACTIVE PROTEINS OF THE MYCOBACTERIA. THIS ANTIGEN CONTAINS EPITOPES THAT ARE COMMON TO VARIOUS SPECIES OF MYCOBACTERIA. Contains PS00296 Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY. X2BF25,P0A521 No NC_002945.3 Mycobrowser_v2 CDS 531315 531743 . - 0 Mb0449c HYPOTHETICAL PROTEIN Mb0449c, -, len: 142 aa. Equivalent to Rv0441c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Hypothetical unknown protein. X2BEY3,P0A5C8 No conserved hypotheticals Rv0441c NC_002945.3 Mycobrowser_v2 CDS 531770 533209 . - 0 Mb0450c PPE10 ppe family protein ppe10 Mb0450c, PPE10, len: 479 aa. Equivalent to Rv0442c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 479 aa overlap). Member of the Mycobacterium tuberculosis PPE family, nearly identical to hypothetical protein from Mycobacterium tuberculosis (strain Erdman) and to AN5S46909_1 protein fragment from Mycobacterium bovis (302 aa); P42611|YHS6_MYCTU HYPOTHETICAL 50.6 KD PROTEIN (517 aa), FASTA scores: opt: 3144, E(): 0, (98.4 identity in 492 aa overlap); and S46909|S46909_1 (302 aa), FASTA scores: opt: 1897, E(): 0,(98.0% identity in 302 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 5' start due to a single base transition (g-a), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Q7U1Z9 No NC_002945.3 Mycobrowser_v2 CDS 534852 535415 . - 0 Mb0453c sigK alternative rna polymerase sigma factor sigk Mb0453c, sigK, len: 187 aa. Equivalent to Rv0445c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable sigK,alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. 5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase sigma factor from Streptomyces coelicolor (185 aa); NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase sigma factor from Mesorhizobium loti (179 aa); 1654108|AAB17906.1|U11283|A58883 probable transcription initiation factor sigma E from Rhodobacter phaeroides (168 aa), FASTA scores: opt: 299, E(): 2e-14, (32.7% identity in 168 aa overlap); Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FACTOR SIGW from Bacillus subtilis (187 aa), FASTA scores: opt: 213, E(): 2.9e-08, (26.8% identity in 179 aa overlap); etc. X2BF30,Q7U1Z6 No NC_002945.3 Mycobrowser_v2 CDS 535464 536234 . - 0 Mb0454c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0454c, -, len: 256 aa. Equivalent to Rv0446c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible conserved transmembrane protein, similar at N-terminus to U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3 from Streptomyces coelicolor (226 aa), FASTA scores: opt: 207, E(): 9.8e-07, (34.2% identity in 114 aa overlap). Also similar to others hypothetical proteins e.g. AAK04680.1|AE006291_14|AE006291) HYPOTHETICAL PROTEIN from Lactococcus lactis subsp. lactis (257 aa). Q7U1Z5 No cell wall and cell processes Rv0446c NC_002945.3 Mycobrowser_v2 CDS 636817 637119 . - 0 Mb0557c conserved protein Mb0557c, -, len: 100 aa. Equivalent to Rv0543c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Conserved hypothetical protein, equivalent to Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 493, E(): 6.1e-30, (73.5% identity in 98 aa overlap). Some similarity to Rv3046c|NP_217562.1 from Mycobacterium tuberculosis. Q7U1T4 No conserved hypotheticals Rv0543c NC_002945.3 Mycobrowser_v2 CDS 536243 537526 . - 0 Mb0455c ufaA1 probable cyclopropane-fatty-acyl-phospholipid synthase ufaa1 (cyclopropane fatty acid synthase) (cfa synthase) Mb0455c, ufaA1, len: 427 aa. Equivalent to Rv0447c,len: 427 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 427 aa overlap). Probable ufaA1,cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79), similar to others e.g. NP_102178.1|14021351|BAB47964.1|AP002994 cyclopropane-fatty-acyl-phospholipid synthase from Mesorhizobium loti (378 aa); B82240|9655593|AAF94281.1|AE004192 cyclopropane-fatty-acyl-phospholipid synthase from Vibrio cholerae (432 aa); P30010|CFA_ECOLI CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3 LPD-3 from P.putida (394 aa), FASTA scores: opt: 556, E(): 2.8e-30, (33.3% identity in 387 aa overlap); AE0005|HPAE000557_9 from Helicobacter pylori (389 aa),FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity in 382 aa overlap). Q7U1Z4 No NC_002945.3 Mycobrowser_v2 CDS 537523 538188 . - 0 Mb0456c CONSERVED HYPOTHETICAL PROTEIN Mb0456c, -, len: 221 aa. Equivalent to Rv0448c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa),FASTA scores: opt: 257, E(): 1.4e-10, (32.0% identity in 197 aa overlap); etc. Some similarity to U15183|MLU15183_38 from Mycobacterium leprae (82 aa),FASTA scores: opt: 134, E(): 0.014, (71.0% identity in 31 aa overlap). Q7U1Z3 No conserved hypotheticals Rv0448c NC_002945.3 Mycobrowser_v2 CDS 555035 555328 . + 0 Mb0472 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0472, -, len: 97 aa. Equivalent to Rv0463, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Probable conserved transmembrane protein, highly similar to AAA63017.1|U15183 hypothetical protein from Mycobacterium leprae (101 aa),FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in 95 aa overlap). Q7U1Y0 No cell wall and cell processes Rv0463 NC_002945.3 Mycobrowser_v2 CDS 1243342 1244202 . - 0 Mb1149c conserved protein Mb1149c, -, len: 286 aa. Equivalent to Rv1118c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 286 aa overlap). Conserved hypothetical protein, similar to pseudogene ML0942 in Mycobacterium leprae. Q7TVC0 No conserved hypotheticals Rv1118c NC_002945.3 Mycobrowser_v2 CDS 538248 539567 . - 0 Mb0457c CONSERVED HYPOTHETICAL PROTEIN Mb0457c, -, len: 439 aa. Equivalent to Rv0449c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 439 aa overlap). Conserved hypothetical protein, some similarity with several hypothetical proteins and various enzymes e.g. AAK24569.1|AE005927 amine oxidase, flavin-containing from Caulobacter crescentus (454 aa); BAB02771.1|AB023036 mycolic acid methyl transferase-like protein from Arabidopsis thaliana (842 aa); BAB01742.1|AP000374 protein which contains similarity to cyclopropane fatty acid synthase from Arabidopsis thaliana (793 aa); etc. Has hydrophobic stretch at N-terminus. Q7U1Z2 No conserved hypotheticals Rv0449c NC_002945.3 Mycobrowser_v2 CDS 539607 542510 . - 0 Mb0458c mmpL4 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL4 Mb0458c, mmpL4, len: 967 aa. Equivalent to Rv0450c,len: 967 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 967 aa overlap). Probable mmpL4,conserved transmembrane transport protein (see citations below), member of RND superfamily, equivalent to U1740V|P54881|YV34_MYCLE HYPOTHETICAL 105.2 kDa PROTEIN from Mycobacterium leprae (959 aa), FASTA scores: opt: 5051, E(): 0, (78.4% identity in 962 aa overlap). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores: opt: 3917, E(): 0, (61.3% identity in 950 aa overlap),MTCY20G9.34, etc. Contains PS00211 ABC transporters family signature. BELONGS TO THE MMPL FAMILY. TBparse score is 0.948. Q7U1Z1 No NC_002945.3 Mycobrowser_v2 CDS 542507 542929 . - 0 Mb0459c mmpS4 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4 Mb0459c, mmpS4, len: 140 aa. Equivalent to Rv0451c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable mmpS4,conserved membrane protein (see citations below),equivalent to U1740W|P54880|YV33_MYCLE HYPOTHETICAL 16.9 kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 727, E(): 0, (75.9% identity in 137 aa overlap). Also similar to other Mycobacterial proteins e.g. Z84725|MTCY04D9.16c from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0% identity in 138 aa overlap); etc. BELONGS TO THE MMPS FAMILY. TBparse score is 0.953. X2BEZ3,P0A5K3 No NC_002945.3 Mycobrowser_v2 CDS 543161 543871 . + 0 Mb0460 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0460, -, len: 236 aa. Equivalent to Rv0452, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Possible transcriptional regulator, similar to several putative TetR-family transcriptional regulators from Streptomyces coelicolor. Also similar in N-terminus to U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 aa), FASTA score: (76.1% identity in 67 aa overlap). Contains probable helix-turn-helix motif at aa 44-65 (Score 1727, +5.07 SD). Q7U1Z0 No regulatory proteins Rv0452 NC_002945.3 Mycobrowser_v2 CDS 1895926 1896150 . + 0 Mb1710A CONSERVED HYPOTHETICAL PROTEIN Mb1710A, -, len: 74 aa. Equivalent to Rv1684, len: 74 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 74 aa overlap). Conserved hypothetical protein, similar to P75844|YCAR_ECOLI Protein YCAR from Escherichia coli (60 aa), FASTA scores: opt: 108, E(): 0.00022, (39.0% identity in 59 aa overlap). Q7TZS8 No conserved hypotheticals Rv1684 NC_002945.3 Mycobrowser_v2 CDS 544193 545749 . + 0 Mb0461 PPE11 ppe family protein ppe11 Mb0461, PPE11, len: 518 aa. Equivalent to Rv0453,len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 518 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 882, E(): 7e-31, (41.8% identity in 514 aa overlap). Q7U1Y9 No NC_002945.3 Mycobrowser_v2 CDS 545854 546204 . + 0 Mb0462 CONSERVED HYPOTHETICAL PROTEIN Mb0462, -, len: 116 aa. Equivalent to Rv0454, len: 116 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 116 aa overlap). Conserved hypothetical protein, showing similarity with AAA63007.1|U15183 hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 151, E(): 0.0019,(31.5% identity in 89 aa overlap). Q7U1Y8 No conserved hypotheticals Rv0454 NC_002945.3 Mycobrowser_v2 CDS 546394 546840 . - 0 Mb0463c conserved protein Mb0463c, -, len: 148 aa. Equivalent to Rv0455c,len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Conserved hypothetical protein, equivalent to CAC31896.1|AL583925 possible secreted protein from Mycobacterium leprae (153 aa). Has hydrophobic stretch at N-terminus. Q7U1Y7 No conserved hypotheticals Rv0455c NC_002945.3 Mycobrowser_v2 CDS 546908 547822 . - 0 Mb0464c echA2 ENOYL-COA HYDRATASE ECHA2 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0464c, echA2, len: 304 aa. Equivalent to Rv0456c,len 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Probable echA2,enoyl-CoA hydratase (EC 4.2.1.17), similar to other enoyl-coA hydratases e.g. Q13011 PEROXISOMAL ENOYL-COA HYDRATASE-LIKE PROTEIN (328 aa), FASTA scores: opt: 209,E(): 5.3e-07, (31.7% identity in 142 aa overlap). Also similar to several other proteins from Mycobacterium tuberculosis e.g. MTCY09F9.29 FASTA score: (32.9% identity in 146 aa overlap); and MTI376.01c. Q7U1Y6 No NC_002945.3 Mycobrowser_v2 CDS 548095 548376 . - 0 Mb0465c mazf1 possible toxin mazf1 Mb0465c, -, len: 93 aa. Equivalent to Rv0456A, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein; N-terminus highly similar to N-terminal part of P71650|Rv2801c|MT2869|MTCY16B7.42 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (118 aa), FASTA scores: opt: 303, E(): 1e-14, (60.44% identity in 91 aa overlap). Also some similarity in part with other hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid maintenance protein from Xylella fastidiosa (108 aa),FASTA scores: opt: 169, E(): 3.9e-05, (50.820% identity in 61 aa overlap). Q7U1Y5 No virulence, detoxification, adaptation Rv0456A NC_002945.3 Mycobrowser_v2 CDS 548363 548488 . - 0 Mb0466A mazE1 Possible antitoxin MazE1 Mb0466A, len: 41 aa. Equivalent to Rv0456B len: 57 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 40 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazE1,antitoxin, part of toxin-antitoxin (TA) operon with Rv0456A (See Pandey and Gerdes, 2005; Zhu et al., 2006). X2BF33 No virulence, detoxification, adaptation Rv0456B NC_002945.3 Mycobrowser_v2 CDS 548605 550635 . - 0 Mb0466c PROBABLE PEPTIDASE Mb0466c, -, len: 676 aa. Equivalent to Rv0457c,len: 673 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 673 aa overlap). Probable peptidase (EC 3.4.-.-), similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable peptidase (EC 3.4.21.-) (726 aa), FASTA scores: opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8% identity in 299 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa). Q7U1Y4 No intermediary metabolism and respiration Rv0457c NC_002945.3 Mycobrowser_v2 CDS 550694 552217 . + 0 Mb0467 PROBABLE ALDEHYDE DEHYDROGENASE Mb0467, -, len: 507 aa. Equivalent to Rv0458, len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 507 aa overlap). Probable aldehyde dehydrogenase (EC 1.2.1.3), highly similar to many,closest to P46369|THCA_RHOER EPTC-INDUCIBLE ALDEHYDE DEHYDROGENASE from Rhodococcus erythropolis (506 aa),FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa),FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO PROBABLE ALDEHYDE DEHYDROGENASE from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in M. tuberculosis e.g. Rv0768, Rv2858c. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. X2BF41,P63938 No intermediary metabolism and respiration Rv0458 NC_002945.3 Mycobrowser_v2 CDS 552217 552708 . + 0 Mb0468 CONSERVED HYPOTHETICAL PROTEIN Mb0468, -, len: 163 aa. Equivalent to Rv0459, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins. Note that highly similar to products of unidentified orfs in Xanthobacter autotrophicus,AF029733_2 (139 aa), and Rhodococcus erythropolis, REREUTP BC_1 (186 aa). Like MTV038.03, these ORF's are linked to aldehyde dehydrogenase genes. FASTA scores: AF0297|AF029733_2 (139 aa), opt: 439, E(): 6.2e-24, (50.0% identity in 126 aa overlap); and L24492|REREUTPBC_1 (186 aa), opt: 347, E(): 2.1e-17, (52.7% identity in 169 aa overlap). N-terminus also highly similar to AAA63041.1|U15183 ethanolamine permease (eutP) match from Mycobacterium leprae (53 aa). Q7U1Y3 No conserved hypotheticals Rv0459 NC_002945.3 Mycobrowser_v2 CDS 552768 553007 . + 0 Mb0469 CONSERVED HYDROPHOBIC PROTEIN Mb0469, -, len: 79 aa. Equivalent to Rv0460, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 79 aa overlap). Conserved hydrophobic protein, highly similar AAA63024.1|U15183 hypothetical protein from Mycobacterium leprae (56 aa), FASTA scores: opt: 197, E(): 3.7e-09, (63.8% identity in 47 aa overlap). Q7U1Y2 No conserved hypotheticals Rv0460 NC_002945.3 Mycobrowser_v2 CDS 553045 553569 . + 0 Mb0470 PROBABLE TRANSMEMBRANE PROTEIN Mb0470, -, len: 174 aa. Equivalent to Rv0461, len: 174 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 174 aa overlap). Probable transmembrane protein. Q7U1Y1 No cell wall and cell processes Rv0461 NC_002945.3 Mycobrowser_v2 CDS 641576 641884 . - 0 Mb0564c vapc3 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb0564c, -, len: 102 aa. Similar to 5' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 92 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065,and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c. Q7U1S9 No NC_002945.3 Mycobrowser_v2 CDS 553633 555027 . + 0 Mb0471 lpd dihydrolipoamide dehydrogenase lpdc (lipoamide reductase (nadh)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase) Mb0471, lpd, len: 464 aa. Equivalent to Rv0462,len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 464 aa overlap). lpd (alternate gene name: TB49.2), dihydrolipoamide dehydrogenase (EC 1.8.1.4) (see first citation below), equivalent to AAA63016.1|U15183 lipoamide dehydrogenase from Mycobacterium leprae (467 aa), FASTA scores: opt: 2583,E(): 0, (83.1% identity in 467 aa overlap). Also similar to to many e.g. P50970|DLDH_ZYMMO|X82291|ZMLPD_1 DIHYDROLIPOAMIDE DEHYDROGENASE from Z.mobilis (466 aa),FASTA scores: opt: 1198, E(): 0, (42.4 % identity in 465 aa overlap); etc. BELONG TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. X2BF35,P66005 No intermediary metabolism and respiration Rv0462 NC_002945.3 Mycobrowser_v2 CDS 555332 555904 . - 0 Mb0473c conserved protein Mb0473c, -, len: 190 aa. Equivalent to Rv0464c,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 190 aa overlap). Conserved hypothetical protein, highly similar to CAC31982.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (188 aa). Also some similarity with Rv1531|AL022000|MTV045_5|D70820 hypothetical protein from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 9.6e-10, (30.9% identity in 175 aa overlap). Q7U1X9 No conserved hypotheticals Rv0464c NC_002945.3 Mycobrowser_v2 CDS 555901 557325 . - 0 Mb0474c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0474c, -, len: 474 aa. Equivalent to Rv0465c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 474 aa overlap). Probable transcriptional regulator, highly similar to AC44331.1|AL596102 putative DNA-binding protein from Streptomyces coelicolor (489 aa); and similar to several hypothetical proteins and others transcriptional regulators. Some similarity in N-terminal region (1-100 aa) with repressors e.g. P06153|RPC_BPPH1 IMMUNITY REPRESSOR PROTEIN (144 aa), FASTA scores: opt: 130, E(): 0.084,(27.0% identity in 100 aa overlap). Very similar to Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium tuberculosis (486 aa), FASTA scores: opt: 1475, E(): 0,(47.4% identity in 468 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (1827, +5.41 SD). Q7U1X8 No regulatory proteins Rv0465c NC_002945.3 Mycobrowser_v2 CDS 557477 558271 . + 0 Mb0475 conserved protein Mb0475, -, len: 264 aa. Equivalent to Rv0466, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Conserved hypothetical protein, equivalent to CAC31980.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (264 aa). Similar to Rv2001|Z74025|MTCY39.17c HYPOTHETICAL 28.7 KDA PROTEIN from Mycobacterium tuberculosis (250 aa),FASTA scores: opt: 592, E(): 0, (38.0% identity in 263 aa overlap). Some similarity to several THIOESTERASES e.g. Q42561|ATACPTE17_1 ACYL-(ACYL CARRIER PROTEIN) THIOESTER from A. thaliana (362 aa), FASTA scores: E(): 0.0092,(24.4% identity in 197 aa overlap). Q7U1X7 No conserved hypotheticals Rv0466 NC_002945.3 Mycobrowser_v2 CDS 558546 559832 . + 0 Mb0476 icl ISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE) Mb0476, icl, len: 428 aa. Equivalent to Rv0467,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). icl (previously known as aceA), isocitrate lyase (EC 4.1.3.1) (see citations below), highly similar to many, closest to Z29367|RFISCILY_1 from R. fascians (429 aa), FASTA scores: opt: 2359, E(): 0, (80.7% identity in 429 aa overlap). BELONGS TO THE ISOCITRATE LYASE FAMILY. X2BF40,P0A5H4 No intermediary metabolism and respiration Rv0467 NC_002945.3 Mycobrowser_v2 CDS 559914 560774 . + 0 Mb0477 fadB2 3-hydroxybutyryl-coa dehydrogenase fadb2 (beta-hydroxybutyryl-coa dehydrogenase) (bhbd) Mb0477, fadB2, len: 286 aa. Equivalent to Rv0468,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable fadB2,3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157),equivalent to CAC31978.1|AL583925 3-hydroxyacyl-CoA dehydrogenase from Mycobacterium leprae (287 aa). Also similar to many 3-hydroxybutyryl-CoA dehydrogenases e.g. U32229|BJU32229_1 beta-hydroxybutyryl coenzyme A dehydrogenase from Bradyrhizobium japonicum (293 aa),FASTA scores: opt: 771, E(): 0, (45.7% identity in 282 aa overlap). BELONGS TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY. Q7U1X6 No NC_002945.3 Mycobrowser_v2 CDS 560907 561767 . + 0 Mb0478 umaA1 possible mycolic acid synthase umaa Mb0478, umaA1, len: 286 aa. Equivalent to Rv0469,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible umaA1,mycolic acid synthase (EC 2.-.-.-), highly similar to CAC30854.1|AL583923 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa),FASTA scores: opt: 1402, E(): 0, (69.6% identity in 286 aa overlap). Also very similar to mycobacterial methyltransferases e.g. U77466|CmaD|MBU77466_1 (286 aa); MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar to CFA1_MYCTU|Q11195|U66108|MTU66108_1 cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa),FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa overlap) (see citation below); and very similar also to methoxy mycolic acid synthase 1 from Mycobacterium tuberculosis e.g. MTU66108_1 (286 aa). Q7U1X5 No NC_002945.3 Mycobrowser_v2 CDS 561867 562730 . - 0 Mb0479c pcaA MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) Mb0479c, pcaA, len: 287 aa. Equivalent to Rv0470c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). pcaA (previously known as umaA2), mycolic acid synthase (cyclopropane synthase) (EC 2.-.-.-) (see citations below), equivalent to CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa); and highly similar to S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical protein from Mycobacterium leprae (308 aa); Q11195|CFA1_MYCTU CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) (287 aa) (see second citation below); U27357|MTU27357_1 cyclopropane mycolic acid synthase from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 1415, E(): 0,(72.8% identity in 287 aa overlap); and related enzymes e.g. MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA scores: opt: 1387, E(): 0, (72.5% identity in 287 aa overlap). Q7U1X4 No NC_002945.3 Mycobrowser_v2 CDS 562873 563313 . - 0 Mb0480c HYPOTHETICAL PROTEIN Mb0480c, -, len: 146 aa. Equivalent to Rv0470A,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein, could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in Mycobacterium bovis and CDC1551. Weak hits to Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: 132, E(): 1.1, (39.35% identity in 61 aa overlap). Q7U1X3 No conserved hypotheticals Rv0470A NC_002945.3 Mycobrowser_v2 CDS 563244 563732 . - 0 Mb0481c HYPOTHETICAL PROTEIN Mb0481c, -, len: 162 aa. Equivalent to Rv0471c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Hypothetical unknown protein. Q7U1X2 No conserved hypotheticals Rv0471c NC_002945.3 Mycobrowser_v2 CDS 563742 564446 . - 0 Mb0482c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0482c, -, len: 234 aa. Equivalent to Rv0472c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable regulatory protein, possibly tetR family, equivalent to CAC31974.1|AL583925 possible TetR-family transcriptional regulator from Mycobacterium leprae (233 aa). Also similar to CAC01492.1|AL391017 putative transcriptional regulatory protein from Streptomyces coelicolor (218 aa); and CAC01371.1|AL390975 putative tetR-family transcriptional regulator from Streptomyces coelicolor (228 aa). Also similar to AL0212|MTV012_65 from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 327, E(): 1.8e-15, (31.0% identity in 232 aa overlap); and Z95120|MTCY07D11.18c (228 aa), FASTA scores: opt: 190,E(): 4.4e-06, (23.1% identity in 186 aa overlap). Contains probable helix-turn-helix doimain at aa 45-66 (Score 1429,+4.05 SD). Q7U1X1 No regulatory proteins Rv0472c NC_002945.3 Mycobrowser_v2 CDS 564583 565953 . + 0 Mb0483 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0483, -, len: 456 aa. Equivalent to Rv0473, len: 456 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 456 aa overlap). Possible conserved transmembrane protein, showing some similarity to hypothetical proteins e.g. NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical protein from Mesorhizobium loti (431 aa); P39385|YJIN_ECOLI|YJIN|B4336 HYPOTHETICAL 48.2 KD PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain K12 (426 aa), FASTA scores: opt: 396, E(): 9.8e-19, (31.8 % identity in 424 aa overlap); etc. Q7U1X0 No cell wall and cell processes Rv0473 NC_002945.3 Mycobrowser_v2 CDS 566040 566462 . + 0 Mb0484 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0484, -, len: 140 aa. Equivalent to Rv0474, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable transcriptional regulator, highly similar to others e.g. CAC04034.1|AL391406 putative DNA-binding protein from Streptomyces coelicolor (141 aa); N-terminus of NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional regulator from Mesorhizobium loti (219 aa); N-terminus of A83618|PA0225 probable transcription regulator from Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr protein from Bacillus subtilis (111 aa), FASTA scores: opt: 147, E(): 8.9e-06, (30.6% identity in 111 aa overlap). Also similar to other hypothetical proteins e.g. X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa),FASTA scores: opt: 280, E(): 4.8e-12, (43.6% identity in 117 aa overlap). Also similar to Rv2745c from Mycobacterium tuberculosis. Contains probable helix-turn-helix domain at aa 35-56 (Score 1709, +5.01 SD). Q7U1W9 No regulatory proteins Rv0474 NC_002945.3 Mycobrowser_v2 CDS 566816 567415 . + 0 Mb0485 hbhA iron-regulated heparin binding hemagglutinin hbha (adhesin) Mb0485, hbhA, len: 199 aa. Equivalent to Rv0475,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). hbhA, heparin-binding hemagglutinin (see citations below), equivalent to CAC31971.1|AL583925 possible hemagglutinin from Mycobacterium leprae (188 aa). Contains possible N-terminal signal sequence and K-A-rich region at C-terminus: SUBCELLULAR LOCATION: SURFACE ASSOCIATED. X2BF49,P0C2T3 No cell wall and cell processes Rv0475 NC_002945.3 Mycobrowser_v2 CDS 567527 567790 . + 0 Mb0486 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0486, -, len: 87 aa. Equivalent to Rv0476, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Possible conserved transmembrane protein, equivalent to CAC31970.1|AL583925 conserved membrane protein from Mycobacterium leprae (95 aa). Also highly similar to CAC04036.1|AL391406 putative membrane protein from Streptomyces coelicolor (113 aa). Contains PS00606 Beta-ketoacyl synthases active site. X2BF48,P64696 No cell wall and cell processes Rv0476 NC_002945.3 Mycobrowser_v2 CDS 622057 623274 . + 0 Mb0543 conserved protein Mb0543, -, len: 405 aa. Equivalent to Rv0530, len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. AL031231|SC3C3_3|CAA20252.1 from Streptomyces coelicolor (1083 aa), FASTA scores: opt: 870, E(): 0, (39.5% identity in 443 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3868, Rv0282, Rv1798, etc. Q7U1U4 No conserved hypotheticals Rv0530 NC_002945.3 Mycobrowser_v2 CDS 568241 568915 . + 0 Mb0488 deoC PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE) Mb0488, deoC, len: 224 aa. Equivalent to Rv0478,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable deoC,deoxyribose-phosphate aldolase (EC 4.1.2.4), equivalent to Q9CB45|DEOC_MYCLE DEOXYRIBOSE-PHOSPHATE ALDOLASE from M. leprae (226 aa). Also highly similar to others e.g. DEOC_BACSU|P39121 from Bacillus subtilis (214 aa), FASTA scores: opt: 543, E(): 1.4e-26, (45.9% identity in 209 aa overlap); etc. BELONGS TO THE DEOC/FBAB FAMILY OF ALDOLASES, DEOC SUBFAMILY. X2BF23,P63930 No intermediary metabolism and respiration Rv0478 NC_002945.3 Mycobrowser_v2 CDS 568940 569986 . - 0 Mb0489c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0489c, -, len: 348 aa. Equivalent to Rv0479c,len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 348 aa overlap). Probable conserved membrane protein, equivalent to CAC31967.1|AL583925 possible secreted protein from Mycobacterium leprae (254 aa); and C-terminus highly similar to AAF74996.1|AF143402_1|AF143402 putative multicopper oxidase from Mycobacterium avium (149 aa). Contains hydrophobic domain in centre of protein. X2BF60,P64700 No cell wall and cell processes Rv0479c NC_002945.3 Mycobrowser_v2 CDS 589476 590318 . + 0 Mb0509 CONSERVED HYPOTHETICAL PROTEIN Mb0509, -, len: 280 aa. Equivalent to Rv0498, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to P54581|Y498_MYCLE|ML2432 HYPOTHETICAL 30.5 KDA PROTEIN from Mycobacterium leprae (280 aa); and S72896|B2168_C2_210 hypothetical protein from Mycobacterium leprae (244 aa), FASTA scores: opt: 1486,E():0, (89.3% identity in 244 aa overlap). Also similar to Q9X8H0|Y714_STRCO|SCE7.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor. X2BF84 No conserved hypotheticals Rv0498 NC_002945.3 Mycobrowser_v2 CDS 569983 570918 . - 0 Mb0490c possible amidohydrolase Mb0490c, -, len: 311 aa. Equivalent to Rv0480c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Conserved hypothetical protein, equivalent, but longer 60 aa in N-terminus, to CAC31966.1|AL583925 putative hydrolase from Mycobacterium leprae (271 aa). Also similar to several hypothetical proteins and hydrolases e.g. AL096822|SCGD3_8 probable hydrolase from Streptomyces coelicolor (264 aa),FASTA scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa overlap); and YAUB_SCHPO|Q10166 hypothetical 35.7 kd protein c26a3.11 from S. pombe (322 aa), FASTA scores: opt: 338, E():1.4e-13, (30.3% identity in 277 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (329 aa versus 340 aa). Q7U1W8 No intermediary metabolism and respiration Rv0480c NC_002945.3 Mycobrowser_v2 CDS 595022 595930 . - 0 Mb0515c cmaA2 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID TRANS-CYCLOPROPANE SYNTHETASE) Mb0515c, cmaA2, len: 302 aa. Equivalent to Rv0503c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). cmaA2 (alternate gene name: cma2), cyclopropane-fatty-acyl-phospholipid synthase 2 (mycolic acid trans-cyclopropane synthetase) (EC 2.1.1.79) (see citations below). Note that this protein has 302 aa and not 322 aa: we have chosen a different initiation codon on the basis of homology). Equivalent to S72886|B2168_F3_130 hypothetical protein from Mycobacterium leprae (308 aa), FASTA score: (78.9% identity in 303 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also similar to other proteins from Mycobacterium tuberculosis and Mycobacterium bovis BCG e.g. MTV038_14|UMAA2|Rv0470c|MTV038.14 PUTATIVE MYCOLIC ACID SYNTHESIS/MODIFICATION PROTEIN (287 aa) (57.2% identity in 297 aa overlap). X2BFA2,P0A5P1 No NC_002945.3 Mycobrowser_v2 CDS 571502 572611 . + 0 Mb0492 murB PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE) Mb0492, murB, len: 369 aa. Equivalent to Rv0482,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Probable murB,UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158), equivalent to CAC31964.1|AL583925 UDP-N-acetylenolpyruvoylglucosamine reductase from Mycobacterium leprae (367 aa). Also highly similar to others e.g. MURB_ECOLI|P08373 UDP-N-acetylenolpyruvoylglucosamine reductase from Escherichia coli (342 aa), FASTA scores: opt: 292, E(): 6.3e-12, (33.5% identity in 355 aa overlap); etc. BELONGS TO THE MURB FAMILY. COFACTOR: FAD. X2BF62,P65461 No cell wall and cell processes Rv0482 NC_002945.3 Mycobrowser_v2 CDS 572673 574028 . + 0 Mb0493 lprQ PROBABLE CONSERVED LIPOPROTEIN LPRQ Mb0493, lprQ, len: 451 aa. Equivalent to Rv0483,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). Probable lprQ,conserved lipoprotein, equivalent to CAC31963.1|AL583925|ML2446 possible lipoprotein from Mycobacterium leprae (441 aa); appears longer than ML2446,so start may be further downstream. Shows also similarity with MLCL383_24|O07707 HYPOTHETICAL 43.6 KD PROTEIN from Mycobacterium leprae; and to Q49706|B1496_F2_81 (271 aa). Similar to others lipoproteins from other organisms. Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0116c, Rv0192, Rv1433, Rv2518c. Contains potential N-terminal signal sequence and appropriately positioned PS00013 prokaryotic membrane lipoprotein lipid attachment site. X2BF28,P64704 No cell wall and cell processes Rv0483 NC_002945.3 Mycobrowser_v2 CDS 574009 574764 . - 0 Mb0494c probable short-chain type oxidoreductase Mb0494c, -, len: 251 aa. Equivalent to Rv0484c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Probable short-chain oxidoreductase (EC 1.-.-.-), highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. STRONG SIMILARITY,TO BACTERIAL YDFG HOMOLOGS. Q7U1W7 No intermediary metabolism and respiration Rv0484c NC_002945.3 Mycobrowser_v2 CDS 666676 666843 . - 0 Mb0587A HYPOTHETICAL PROTEIN Mb0587A, -, len: 55 aa. Equivalent to Mt0407.1 from Mycobacterium tuberculosis strain CDC1551, (100% identity with 55 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb0587A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BFF4 No NC_002945.3 Mycobrowser_v2 CDS 574947 576263 . + 0 Mb0495 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0495, -, len: 438 aa. Equivalent to Rv0485, len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Possible transcriptional repressor, member of the NAGC/XYLR repressor FAMILY; similar to several e.g. D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor from Vibrio cholerae (404 aa), FASTA scores: opt: 378,E(): 1.2e-17, (26.9% identity in 350 aa overlap); NAGC_ECOLI|P15301 N-acetylglucosamine repressor from Escherichia coli (406 aa), FASTA scores: opt: 305, E(): 1.8e-12, (21.8% identity in 357 aa overlap); etc. X2BF70 No regulatory proteins Rv0485 NC_002945.3 Mycobrowser_v2 CDS 590334 591209 . + 0 Mb0510 CONSERVED HYPOTHETICAL PROTEIN Mb0510, -, len: 291 aa. Equivalent to Rv0499, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Conserved hypothetical protein, showing some similarity to AL031184|SC2A11_16|T34762 hypothetical protein from Streptomyces coelicolor (340 aa), FASTA scores: opt: 240,E(): 1.8e-07, (28.9% identity in 270 aa overlap). X2BF78,P64720 No conserved hypotheticals Rv0499 NC_002945.3 Mycobrowser_v2 CDS 576311 577753 . + 0 Mb0496 msha glycosyltransferase msha Mb0496, -, len: 480 aa. Equivalent to Rv0486, len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Mannosyltransferase (EC 2.4.1.-) (see citations below), highly similar to P54138|Y486_MYCLE|ML2443 possible glycosyl transferase from Mycobacterium leprae (428 aa); and S72892|B2168_C2_201 probable hexosyltransferase (EC 2.4.1.-) from Mycobacterium leprae (409 aa), FASTA scores: opt: 2375, E(): 0, (86.4% identity in 413 aa overlap). Also highly similar to CAC04040.1|AL391406 putative transferase from Streptomyces coelicolor (496 aa); and similar to various transferases e.g. NP_437172.1|NC_003078 putative membrane-anchored glycosyltransferase protein from Sinorhizobium meliloti (416 aa); O26550|U67601_1 LPS BIOSYNTHESIS RELATED PROTEIN from Methanococcus jannaschii (411 aa), FASTA score: (25.3% identity in 387 aa overlap); etc. Also similar to CAC87824.1|AJ316594 putative sucrose-phosphate synthase from Nostoc punctiforme (422 aa). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature. X2BF79,P64708 No intermediary metabolism and respiration Rv0486 NC_002945.3 Mycobrowser_v2 CDS 577750 578301 . + 0 Mb0497 CONSERVED HYPOTHETICAL PROTEIN Mb0497, -, len: 183 aa. Equivalent to Rv0487, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, highly similar to P54139|Y487_MYCLE|U00018_38|ML2442 HYPOTHETICAL 20.8 KDA PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa overlap). Also highly similar to CAC04041.1|AL391406 conserved hypothetical protein from Streptomyces coelicolor (168 aa). X2BF77 No conserved hypotheticals Rv0487 NC_002945.3 Mycobrowser_v2 CDS 578685 579290 . + 0 Mb0498 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0498, -, len: 201 aa. Equivalent to Rv0488, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to others and conserved hypothetical proteins e.g. AB93746.1|AL357613 putative membrane transport protein from Streptomyces coelicolor (204 aa); D83100|PA4365 probable transporter from Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667 hypothetical 21.7 kd protein from Escherichia coli (197 aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity in 179 aa overlap); CGLYSEG_2 C|P94633 LYSINE EXPORTER PROTEIN (236 aa), FASTA scores: E(): 2.3e-07, (33.3% identity in 219 aa overlap). Also similar to Rv1986 from Mycobacterium tuberculosis. X2BF53,P64712 No cell wall and cell processes Rv0488 NC_002945.3 Mycobrowser_v2 CDS 579447 580196 . + 0 Mb0499 gpm1 PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) Mb0499, gpm1, len: 249 aa. Equivalent to Rv0489,len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Probable gpm1,phosphoglycerate mutase 1 (EC 5.4.2.1), equivalent to P53531|PMGY_MYCLE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (247 aa). Also highly similar to others e.g. PMG1_ECOLI|P31217 (249 aa), FASTA scores: opt: 805, E(): 0, (51.4% identity in 245 aa overlap); etc. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOSPHOGLYCERATE MUTASE FAMILY. Note that previously known as gpm. X2BF75,P0A5R7 No intermediary metabolism and respiration Rv0489 NC_002945.3 Mycobrowser_v2 CDS 580370 581602 . + 0 Mb0500 senX3 PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 Mb0500, senX3, len: 410 aa. Equivalent to Rv0490,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 410 aa overlap). Putative senX3,two-component sensor histidine kinase (EC 2.7.3.-),transmembrane protein (see citations below), equivalent to O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0,(99.5% identity in 410 aa overlap); and highly similar to P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from Mycobacterium leprae (443 aa), FASTA score: (83.8% identity in 408 aa overlap). Also highly similar, except in N-terminus, to CAC31957.1|AL583925 probable two-component system sensor histidine kinase from Mycobacterium leprae (441 aa). Also highly similar to sensor kinase proteins from other organisms e.g. CAB77323.1|AL160331 putative sensor kinase protein from Streptomyces coelicolor (426 aa). X2BF71,P0A601 No NC_002945.3 Mycobrowser_v2 CDS 581960 582643 . + 0 Mb0501 regX3 TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) Mb0501, regX3, len: 227 aa. Equivalent to Rv0491,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). regX3, response regulator protein (sensory transduction protein) (see citations below), equivalent to O07130|RGX3_MYCBO|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium bovis BCG (227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response regulator from Mycobacterium smegmatis (228 aa); equivalent to P54884|RGX3_MYCLE|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium leprae (198 aa), FASTA scores : E(): 0, (95.4% identity in 197 aa overlap). Also highly similar to other response regulators e.g. AAG43239.1|AF123314_2 |AF123314 putative response regulator from Corynebacterium glutamicum (232 aa). X2BF91,O07130 No NC_002945.3 Mycobrowser_v2 CDS 582640 584529 . - 0 Mb0502c PROBABLE OXIDOREDUCTASE GMC-TYPE Mb0502c, -, len: 629 aa. Equivalent to Rv0492c,len: 629 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 629 aa overlap). Probable oxidoreductase GMC type (EC 1.-.-.-), similar to others except in N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN HYPOTHETICAL GMC-TYPE OXIDOREDUCTASE from Rhizobium sp. (505 aa), FASTA scores: opt: 873, E():0, (34.3% identity in 502 aa overlap); YTH2_RHOER|P46371 HYPOTHETICAL 53.0 kd GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa), FASTA score: (25.7% identity in 521 aa overlap); YTH2_RHOSO|P46371 hypothetical 53.0 kd gmc-type oxidoreductase from Rhodococcus erythropolis (493 aa),FASTA score: (25.7% identity in 521 aa overlap); NP_085596.1|NC_002679 probable oxidoreductase from Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC oxidoreductase from Deinococcus radiodurans (722 aa); NP_249055.1|NC_002516 probable oxidoreductase from Pseudomonas aeruginosa (531 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD (BY SIMILARITY). Note that start changed since first submission (previously 684 aa). Q7U1W6 No intermediary metabolism and respiration Rv0492c NC_002945.3 Mycobrowser_v2 CDS 585846 586574 . + 0 Mb0505 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0505, -, len: 242 aa. Equivalent to Rv0494, len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Probable transcriptional regulator, GntR family, with C-terminal part highly similar to S72893|B2168_C2_205 hypothetical protein from Mycobacterium leprae (105 aa). Also similar to other transcription regulators e.g. PDHR_ECOLI|P06957 pyruvate dehydrogenase complex repressor PDHR or GENA from Escherichia coli (254 aa), FASTA scores: opt: 284, E(): 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature, and probable helix-turn helix motif from aa 50-71 (Score 1229, +3.37 SD). X2BF74,P67740 No regulatory proteins Rv0494 NC_002945.3 Mycobrowser_v2 CDS 586575 587465 . - 0 Mb0506c CONSERVED HYPOTHETICAL PROTEIN Mb0506c, -, len: 296 aa. Equivalent to Rv0495c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Conserved hypothetical protein, highly similar to S72915|B2168_F1_37 hypothetical protein from Mycobacterium leprae (323 aa),FASTA scores: opt: 1615, E(): 0, (82.7% identity in 271 aa overlap); and P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (271 aa). X2BF95 No conserved hypotheticals Rv0495c NC_002945.3 Mycobrowser_v2 CDS 587545 588531 . + 0 Mb0507 CONSERVED HYPOTHETICAL PROTEIN Mb0507, -, len: 328 aa. Equivalent to Rv0496, len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 328 aa overlap). Conserved hypothetical protein, highly similar to S72894|467046|AAA17230.1|U00018 exopolyphosphatase (EC 3.6.1.11) ppx from Mycobacterium leprae (406 aa), FASTA scores: opt: 1902, E(): 0, (86.6% identity in 343 aa overlap); and P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium leprae (339 aa). Also highly similar to hypothetical proteins and exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa). C-terminal region similar to CGU31224_1|Q46054 protein similar to ppx gene product of Mycobacterium leprae from Cornybacterium glutamicum (140 aa), FASTA scores: opt: 615, E(): 2.7e-33, (70.9% identity in 134 aa overlap). X2BF85,P65787 No conserved hypotheticals Rv0496 NC_002945.3 Mycobrowser_v2 CDS 588528 589460 . + 0 Mb0508 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0508, -, len: 310 aa. Equivalent to Rv0497, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Probable conserved transmembrane protein, equivalent (but shorter in C-terminus) to P54580|Y497_MYCLE|ML2433 HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium leprae (355 aa). N-terminus highly similar to S72922|B2168_C1_166|467074 hypothetical protein from Mycobacterium leprae (118 aa), FASTA scores: opt: 350, E(): 1.4e-12, (57.9% identity in 114 aa overlap); and hydrophobic C-terminus, highly similar to S72895|B2168_C2_209|467047 hypothetical protein from Mycobacterium leprae (241 aa), FASTA scores: opt: 473,E(): 8e-19, (53.9% identity in 241 aa). X2BF59,P64716 No cell wall and cell processes Rv0497 NC_002945.3 Mycobrowser_v2 CDS 1453212 1453454 . + 0 Mb1330 rpmE 50s ribosomal protein l31 rpme Mb1330, rpmE, len: 80 aa. Equivalent to Rv1298,len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 80 aa overlap). Probable rpmE, 50s ribosomal protein L31, highly similar to many e.g. RL31_MYCLE|P45834 50s ribosomal protein L31 from Mycobacterium leprae (84 aa), FASTA scores: opt: 490, E(): 5.5e-28, (89.6% identity in 77 aa overlap). Contains PS01143 Ribosomal protein L31 signature. BELONGS TO THE L31P FAMILY OF RIBOSOMAL PROTEINS. X2BHB4,P66188 No information pathways Rv1298 NC_002945.3 Mycobrowser_v2 CDS 621041 622015 . + 0 Mb0542 ccsA POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCSA Mb0542, ccsA, len: 324 aa. Equivalent to Rv0529,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Possible ccsA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to NP_302558.1|NC_002677|B2168_C3_281 possible cytochrome C biogenesis protein from Mycobacterium leprae (327 aa), FASTA scores: opt: 1779,E(): 0, (82.9% identity in 327 aa overlap). Also highly similar to others e.g. CAC08382.1|AL392176 putative cytochrome biogenesis related protein from Streptomyces coelicolor (380 aa); CCSA_CHLRE|P48269 probable cytochrome c biogenesis protein from Chlamydomonas reinhardtii (353 aa), FASTA scores: opt: 449, E(): 1.3e-23, (34.4% identity in 247 aa overlap); etc. BELONGS TO THE CCMF/CYCK/CCL1/NRFE/CCSA FAMILY. Note that previously known as ccsB. Q7U1U5 No intermediary metabolism and respiration Rv0529 NC_002945.3 Mycobrowser_v2 CDS 591234 592121 . + 0 Mb0511 proC PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C REDUCTASE) Mb0511, proC, len: 295 aa. Equivalent to Rv0500,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable proC,Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (see citation below), equivalent to P46725|PROC_MYCLE PYRROLINE-5-CARBOXYLATE REDUCTASE from Mycobacterium leprae (294 aa), FASTA scores: opt: 1473, E(): 0, (82.4% identity in 295 aa overlap). Also similar to others e.g. P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTASE from Corynebacterium glutamicum (270 aa); T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate reductase from Streptomyces coelicolor (284 aa); etc. BELONGS TO THE PYRROLINE-5-CARBOXYLATE REDUCTASE FAMILY. Q7U1W3 No intermediary metabolism and respiration Rv0500 NC_002945.3 Mycobrowser_v2 CDS 592262 592498 . + 0 Mb0512 conserved protein Mb0512, -, len: 78 aa. Equivalent to Rv0500A, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): 1.3e-27, (82.6% identity in 86 aa overlap); AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 identity in 54 aa overlap). Q7U1W2 No conserved hypotheticals Rv0500A NC_002945.3 Mycobrowser_v2 CDS 592626 592727 . + 0 Mb0512A Conserved hypothetical protein Mb0512A, len: 33 aa. Equivalent to Rv0500B len: 33 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 33 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein. Basic protein 18 of the 33 aa are Arg or Lys,with strong similarity to AL079345|SCE68_25 protein from Streptomyces coelicolor cosmid E6 (32 aa), FASTA scores: opt: 176, E(): 1e-06, (93.1% identity in 29 aa overlap). Same gene arrangement in both actinomycetes. X2BF61 No conserved hypotheticals Rv0500B NC_002945.3 Mycobrowser_v2 CDS 592805 593935 . + 0 Mb0513 galE2 POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE) Mb0513, galE2, len: 376 aa. Equivalent to Rv0501,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible galE2,UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar (except in N-terminus) to CAC31944.1|AL583925 possible glucose epimerase/dehydratase from Mycobacterium leprae (364 aa). N-terminus highly similar to S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical protein from Mycobacterium leprae (180 aa), FASTA scores: opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and C-terminus highly similar to S72898|467050|AAA17234.1|U00018 hypothetical protein from Mycobacterium leprae (168 aa), FASTA scores: opt: 928,E(): 0, (82.7% identity in 168 aa overlap). Also highly similar to T36274|5123671|CAB45360.1|AL079345 probable epimerase from Streptomyces coelicolor (353 aa); and similar in part to other epimerases e.g. GALE_ECOLI|P09147 UDP-glucose 4-epimerase from Escherichia coli (338 aa),FASTA scores: opt: 241, E(): 6.7e-09, (28.2% identity in 294 aa overlap); etc. BELONGS TO THE SUGAR EPIMERASE FAMILY. COFACTOR: NAD. Note that previously known as galE1. X2BF87,P0A5D2 No NC_002945.3 Mycobrowser_v2 CDS 593942 595018 . + 0 Mb0514 conserved protein Mb0514, -, len: 358 aa. Equivalent to Rv0502, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Conserved hypothetical protein, equivalent to P54878|Y502_MYCLE|ML2427 HYPOTHETICAL 40.5 KDA PROTEIN from Mycobacterium leprae (367 aa), FASTA scores: opt: 2042, E(): 0, (84.1% identity in 365 aa overlap). Also similar to T36273|SCE68.23c hypothetical protein from Streptomyces coelicolor (355 aa). C-terminal similar to AL021529|SC10A5_4|T34572 hypothetical protein from Streptomyces coelicolor (295 aa), FASTA score: (57.8% identity in 263 aa overlap); and to hypothetical proteins from Mycobacterium tuberculosis Rv1920|G70808 (287 aa); and Rv1428c|G70914 (275 aa). X2BF83,P64724 No conserved hypotheticals Rv0502 NC_002945.3 Mycobrowser_v2 CDS 595953 596453 . - 0 Mb0516c conserved protein Mb0516c, -, len: 166 aa. Equivalent to Rv0504c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, equivalent to P54879|Y504_MYCLE|ML2425 HYPOTHETICAL 18.7 KDA PROTEIN from Mycobacterium leprae (166 aa), FASTA scores: opt: 884, E(): 0, (83.1% identity in 166 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). Also similar to M. tuberculosis hypothetical proteins Rv0635|H70612 (158 aa); and Rv0637|B70613 (166 aa). X2BF94 No conserved hypotheticals Rv0504c NC_002945.3 Mycobrowser_v2 CDS 596615 597736 . - 0 Mb0517c serB1 POSSIBLE PHOSPHOSERINE PHOSPHATASE SERB1 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE) Mb0517c, serB1, len: 373 aa. Equivalent to Rv0505c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Possible serB1,phosphoserine phosphatase (EC 3.1.3.3), equivalent (but longer ~70 aa in N-terminus) to S72914|serB phosphoserine phosphatase from Mycobacterium leprae (300 aa), FASTA scores: opt: 1570, E(): 0, (83.0% identity in 306 aa overlap). C-terminus highly similar to CAB55344.1|AJ010584 phosphoserine phosphatase from Streptomyces coelicolor (266 aa). Low similarity to SERB_ECOLI|P06862 phosphoserine phosphatase from Escherichia coli strains K12 and O157:H7 (322 aa), FASTA scores: opt: 148, E(): 0.043, (24.0% identity in 150 aa overlap). C-terminus is also similar to O33611|AB004855_1|IMD_STRCN PROTEIN INVOLVED IN INHIBITION OF MORPHOLOGICAL DIFFERENTIATION from Streptomyces cyaneus (277 aa), FASTA score: (37.7% identity in 252 aa overlap). SEEMS TO BELONG TO THE SERB FAMILY. Note that previously known as serB. X2BF63,P66802 No NC_002945.3 Mycobrowser_v2 CDS 597910 598353 . + 0 Mb0518 mmpS2 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS2 Mb0518, mmpS2, len: 147 aa. Equivalent to Rv0506,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Probable mmpS2,conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. C-terminus of AAD44232.1|AF143772_38|AF143772|TmtpA from M. avium (221 aa); P54880|MMS4_MYCLE|MMPS4 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 392, E(): 1.3e-20, (43.7% identity in 151 aa overlap); and the PUTATIVE MEMBRANE PROTEINS from Mycobacterium tuberculosis MTV040_5, MTCY4D9_16, MTV037_15. BELONGS TO THE MMPS FAMILY. X2BF92,P65377 No NC_002945.3 Mycobrowser_v2 CDS 647541 649205 . + 0 Mb0570 menD PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE) (KDC) Mb0570, menD, len: 554 aa. Equivalent to Rv0555,len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 554 aa overlap). Probable menD,menaquinone biosynthesis protein, including 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.1.3.-) and 2-oxoglutarate decarboxylase (EC 4.1.1.71) activities. Equivalent to NP_302478.1|NC_002677 putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase from Mycobacterium leprae (556 aa). Also similar to others e.g. MEND_BACSU|P23970 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase from Bacillus subtilis (548 aa), FASTA scores: opt: 488, E(): 2.3e-21, (34.3% identity in 545 aa overlap); etc. COFACTOR: THIAMINE PYROPHOSPHATE. X2BFE4,Q7U1S4 No intermediary metabolism and respiration Rv0555 NC_002945.3 Mycobrowser_v2 CDS 598350 601256 . + 0 Mb0519 mmpL2 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL2 Mb0519, mmpL2, len: 968 aa. Equivalent to Rv0507,len: 968 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 968 aa overlap). Probable mmpL2,conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCLE from Mycobacterium leprae (959 aa), FASTA scores: opt: 3699, E(): 0, (58.3% identity in 940 aa overlap); and the Mycobacterium tuberculosis proteins MTV037_14, MTV040_4, MTCY98_8,MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc. Also similar to STMACTII_3|SC10A5_9 from Streptomyces coelicolor; and BSUB0|004_12 from Bacillus subtilis. C-terminal half similar to Q50086|U1740AB from Mycobacterium leprae (386 aa), FASTA scores: opt: 1526,E(): 0, (61.5% identity in 371 aa overlap). BELONGS TO THE MMPL FAMILY. Q7U1W1 No NC_002945.3 Mycobrowser_v2 CDS 601249 601542 . + 0 Mb0520 CONSERVED HYPOTHETICAL PROTEIN Mb0520, -, len: 97 aa. Equivalent to Rv0508, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, showing similarity with T36269|5123666|CAB45355.1|AL079345 probable redoxin from Streptomyces coelicolor (101 aa), FASTA scores: opt: 160,E(): 3.4e-05, (33.3% identity in 75 aa overlap); and E81943|NMA0966 probable thioredoxin from Neisseria meningitidis group A strain Z2491 (77 aa). X2BFA6 No conserved hypotheticals Rv0508 NC_002945.3 Mycobrowser_v2 CDS 601592 602998 . + 0 Mb0521 hemA probable glutamyl-trna reductase hema (glutr) Mb0521, hemA, len: 468 aa. Equivalent to Rv0509,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable hemA,glutamyl-tRNA reductase (EC 1.2.1.-), equivalent to HEM1_MYCLE|P46724 GLUTAMYL-TRNA REDUCTASE from Mycobacterium leprae (467 aa), FASTA scores: opt: 2377,E(): 0, (82.3% identity in 463 aa overlap). Also highly similar (sometimes in part) to others e.g. Q9WX15|HEM1_STRCO GLUTAMYL-TRNA REDUCTASE from Streptomyces coelicolor (581 aa); P16618|HEM1_BACSU|HEMA GLUTAMYL-TRNA REDUCTASE from Bacillus subtilis (455 aa); etc. Contains PS00747 Glutamyl-tRNA reductase signature. BELONGS TO THE GLUTAMYL-TRNA REDUCTASE FAMILY. X2BFA0,P64329 No intermediary metabolism and respiration Rv0509 NC_002945.3 Mycobrowser_v2 CDS 603008 603937 . + 0 Mb0523 hemC PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE) Mb0523, hemC, len: 309 aa. Equivalent to Rv0510,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable hemC,hydroxymethylbilane synthase (porphobilinogen deaminase) (EC 4.3.1.8), equivalent to HEM3B|Q49808|HEM3_MYCLE PORPHOBILINOGEN DEAMINASE from Mycobacterium leprae (315 aa), FASTA scores: opt: 889, E(): 0, (88.1% identity in 159 aa overlap). Also highly similar to others e.g. Q9WX16|HE31_STRCO PROBABLE PORPHOBILINOGEN DEAMINASE from Streptomyces coelicolor (319 aa); Q9L6Q2|HEM3_SALTY PORPHOBILINOGEN DEAMINASE from Salmonella typhimurium (313 aa); etc. BELONGS TO THE HMBS FAMILY. COFACTOR: COVALENTLY BINDS A DIPYRROMETHANE COFACTOR TO WHICH THE PORPHOBILINOGEN SUBUNITS ARE ADDED. X2BF64,P64337 No intermediary metabolism and respiration Rv0510 NC_002945.3 Mycobrowser_v2 CDS 603970 605667 . + 0 Mb0524 hemD PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM) Mb0524, hemD, len: 565 aa. Equivalent to Rv0511,len: 565 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 565 aa overlap). Probable hemD (alternate gene name: cysG), uroporphyrin-III C-methyltransferase (EC 2.1.1.107), highly similar to others e.g. CAC31936.1|AL583925 possible uroporphyrin-III C-methyltransferase from Mycobacterium leprae (563 aa); and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA scores: opt: 1946, E(): 0, (83.3% identity in 472 aa overlap); T36265|5123662|CAB45351.1|AL079345 probable uroporphyrin-III C-methyltransferase from Streptomyces coelicolor (565 aa); and similar to others e.g. AAK00606.1|AF221100_3|AF221100 from Selenomonas ruminantium subsp. ruminantium (505 aa); etc. Also similar to Rv2071c and Rv2847c from Mycobacterium tuberculosis. Note that previously known as cysG. Q7TTP7 No intermediary metabolism and respiration Rv0511 NC_002945.3 Mycobrowser_v2 CDS 605753 606742 . + 0 Mb0525 hemB PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) Mb0525, hemB, len: 329 aa. Equivalent to Rv0512,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 329 aa overlap). Probable hemB,delta-aminolevulinic acid dehydratase (EC 4.2.1.24),equivalent to 46723|HEM2_MYCLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE from Mycobacterium leprae (329 aa). Also highly similar to many e.g. P54919|HEM2_STRCO from Streptomyces coelicolor (330 aa); HEM2_ECOLI|P15002 from Escherichia coli (323 aa), FASTA scores: opt: 942, E(): 0,(47.6% identity in 317 aa overlap); etc. Contains PS00169 Delta-aminolevulinic acid dehydratase active site. BELONGS TO THE ALADH FAMILY. COFACTOR: ZINC. Q7U1W0 No intermediary metabolism and respiration Rv0512 NC_002945.3 Mycobrowser_v2 CDS 606755 607303 . + 0 Mb0526 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0526, -, len: 182 aa. Equivalent to Rv0513, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Possible conserved transmembrane protein, with its N-terminus highly similar to S72925|B2168_C1_182 hypothetical protein from Mycobacterium leprae (103 aa), FASTA scores: opt: 217,E(): 8.2e-14, (45.3 % identity in 106 aa overlap). Q7U1V9 No cell wall and cell processes Rv0513 NC_002945.3 Mycobrowser_v2 CDS 607702 609213 . + 0 Mb0528 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0528, -, len: 503 aa. Equivalent to Rv0515, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Part of M. tuberculosis 13E12 repeat family. Almost identical to Rv0336 (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other M. tuberculosis hypothetical 13E12 repeat proteins e.g. Rv1148c, Rv1945, etc. Q7TTD9 No insertion seqs and phages Rv0515 NC_002945.3 Mycobrowser_v2 CDS 609210 609686 . - 0 Mb0529c possible anti-anti-sigma factor Mb0529c, -, len: 158 aa. Equivalent to Rv0516c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, showing some similarity to Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 aa), FASTA scores: E(): 0.0012, (27.4% identity in 124 aa overlap). Q7U1V7 No information pathways Rv0516c NC_002945.3 Mycobrowser_v2 CDS 1371536 1372069 . - 0 Mb1259c PROBABLE TRANSMEMBRANE PROTEIN Mb1259c, -, len: 177 aa. Equivalent to Rv1227c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 177 aa overlap). Possible transmembrane protein, similar to P96615 hypothetical protein ydbS from Bacillus subtilis (159 aa), fasta scores: E(): 3.6e-07,(30.1% identity in 163 aa overlap). Q7U0C4 No cell wall and cell processes Rv1227c NC_002945.3 Mycobrowser_v2 CDS 649202 649717 . + 0 Mb0571 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0571, -, len: 171 aa. Equivalent to Rv0556, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 171 aa overlap). Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa). Q7U1S3 No cell wall and cell processes Rv0556 NC_002945.3 Mycobrowser_v2 CDS 609897 611207 . + 0 Mb0530 POSSIBLE MEMBRANE ACYLTRANSFERASE Mb0530, -, len: 436 aa. Equivalent to Rv0517, len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 436 aa overlap). Possible acyltransferase (EC 2.3.1.-), integral membrane protein,equivalent (but longer 26 aa in N-terminus) to AAK44761.1|AE006954 putative acyltransferase from Mycobacterium tuberculosis strain CDC1551 (410 aa). Also similar to many acyltransferases e.g. MDMB_STRMY|Q00718 from Streptomyces mycarofaciens (387 aa), FASTA scores: opt: 200, E(): 1.1e-08, (28.2% identity in 394 aa overlap). And similar to Rv0111, Rv0228, Rv1254, Rv1565c from Mycobacterium tuberculosis. Q7U1V6 No intermediary metabolism and respiration Rv0517 NC_002945.3 Mycobrowser_v2 CDS 611339 612034 . + 0 Mb0531 POSSIBLE EXPORTED PROTEIN Mb0531, -, len: 231 aa. Equivalent to Rv0518, len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible exported protein; has hydrophobic N-terminus. Q7U1V5 No cell wall and cell processes Rv0518 NC_002945.3 Mycobrowser_v2 CDS 612322 613224 . - 0 Mb0532c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0532c, -, len: 300 aa. Equivalent to Rv0519c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Possible conserved membrane protein, with hydrophobic region near N-terminus. Could be a lipase (EC 3.1.-.-). Similar to Rv0774c|MTCY369.19c|A70708 from Mycobacterium tuberculosis (312 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00120 Lipases, serine active site. Q7U1V4 No cell wall and cell processes Rv0519c NC_002945.3 Mycobrowser_v2 CDS 641881 642147 . - 0 Mb0565c vapb3 possible antitoxin vapb3 Mb0565c, -, len: 88 aa. Equivalent to Rv0550c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein. Q7U1S8 No virulence, detoxification, adaptation Rv0550c NC_002945.3 Mycobrowser_v2 CDS 613405 613755 . + 0 Mb0533 POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT) Mb0533, -, len: 116 aa. Equivalent to Rv0520, len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). Possible fragment of methyltransferase (possibly first part) (EC 2.1.1.-),highly similar to part of several methyltransferases e.g. Q43445|U43683 S-ADENOSYL-L-METHIONINE:DELTA24-STEROL-C-METHYLTRANSFERASE from Glycine max (Soybean)(367 aa), FASTA scores: opt: 190, E(): 2.3e-12, (39.2% identity in 74 aa overlap). Also some similarity to MTCY19G5_5 from Mycobacterium tuberculosis. Possibly continues as Rv0521 but we can find no frameshift to account for this. Q7U1V3 No intermediary metabolism and respiration Rv0520 NC_002945.3 Mycobrowser_v2 CDS 613748 614053 . + 0 Mb0534 POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT) Mb0534, -, len: 101 aa. Equivalent to Rv0521, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Possible fragment of methyltransferase (possibly second part) (EC 2.1.1.-),highly similar to C-terminus of several methyltransferases e.g. AAF87203.1|AF216282 sarcosine-dimethylglycine methyltransferase from Halorhodospira halochloris (279 aa). Possibly continuation of Rv0520 but we can find no frameshift to account for this. Q7U1V2 No intermediary metabolism and respiration Rv0521 NC_002945.3 Mycobrowser_v2 CDS 614188 615492 . + 0 Mb0535 gabP PROBABLE GABA PERMEASE GABP (4-AMINO BUTYRATE TRANSPORT CARRIER) (GAMA-AMINOBUTYRATE PERMEASE) Mb0535, gabP, len: 434 aa. Equivalent to Rv0522,len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 434 aa overlap). Probable gabP, GABA permease (gamma-aminobutyrate permease), integral membrane protein, highly similar to others e.g. GABP_ECOLI|P25527 gaba permease from Escherichia coli (466 aa), FASTA scores: opt: 1218, E(): 0, (44.3% identity in 424 aa overlap); etc. Also similar to other Mycobacterium tuberculosis permeases e.g. MTCY13E10.06c FASTA score: (34.4% identity in 407 aa overlap). Contains PS00218 Amino acid permeases signature. Overlaps and extends Rv0523c|MTCY25D10.01 from overlapping cosmid. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Q7U1V1 No cell wall and cell processes Rv0522 NC_002945.3 Mycobrowser_v2 CDS 615476 615871 . - 0 Mb0536c conserved protein Mb0536c, -, len: 131 aa. Equivalent to Rv0523c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing some similarity to M. tuberculosis proteins Rv1598c|MTCY336.06; and Rv1871c|MTCY336_06|O06592 (136 aa), FASTA scores: opt: 197, E(): 5e-08, (38.4% identity in 99 aa overlap). Q7U1V0 No conserved hypotheticals Rv0523c NC_002945.3 Mycobrowser_v2 CDS 615985 617373 . + 0 Mb0537 hemL PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) Mb0537, hemL, len: 462 aa. Equivalent to Rv0524,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Probable hemL,glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8),equivalent to P46716|GSA_MYCLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE from Mycobacterium leprae (446 aa), FASTA scores: opt: 1532, E(): 0, (82.6% identity in 460 aa overlap). Also highly similar to others e.g. Q9F2S0|GSA_STRCO from Streptomyces coelicolor (438 aa); Q06774|GSA_PROFR from Propionibacterium freudenreichii (441 aa); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BFC4,P63507 No intermediary metabolism and respiration Rv0524 NC_002945.3 Mycobrowser_v2 CDS 898911 899540 . + 0 Mb0827 CONSERVED HYPOTHETICAL PROTEIN Mb0827, -, len: 209 aa. Equivalent to Rv0804, len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Conserved hypothetical protein, showing similarity with C-terminus of Rv1863c|MTCY359.10 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 199, E(): 1.2e-05, (33.2% identity in 220 aa overlap); and Rv0658c. Contains PS01151 Fimbrial biogenesis outer membrane usher protein signature. Q7U186 No conserved hypotheticals Rv0804 NC_002945.3 Mycobrowser_v2 CDS 617373 617981 . + 0 Mb0538 conserved protein Mb0538, -, len: 202 aa. Equivalent to Rv0525, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein, equivalent to Q49821|B2168_C3_276|S72912 hypothetical protein from Mycobacterium leprae (202 aa), FASTA scores: opt: 1151,E(): 0, (82.5% identity in 200 aa overlap). Also highly similar to CAC08377.1|AL392176 putative phosphoglycerate mutase from Streptomyces coelicolor (233 aa); and similar to SLL0395|Q55734 hypothetical 23.8 kDa protein from SYNECHOCYSTIS SP. (212 aa), FASTA scores: opt: 207, E(): 5.1e-07, (28.2% identity in 195 aa overlap). Also some similarity to Rv2228c|Y019_MYCTU|Q10512|cy427.09 hypothetical 39.2 kd protein from Mycobacterium tuberculosis (364 aa), FASTA scores: opt: 236, E(): 1.1e-08, (34.3% identity in 198 aa overlap). Q7U1U9 No conserved hypotheticals Rv0525 NC_002945.3 Mycobrowser_v2 CDS 618643 619422 . + 0 Mb0540 ccdA POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCDA Mb0540, ccdA, len: 259 aa. Equivalent to Rv0527,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Possible ccdA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to Q49810|B2168_C1_192|S72890 hypothetical protein from Mycobacterium leprae (262 aa),FASTA scores: opt: 1341, E(): 0, (79.0% identity in 262 aa overlap). Also highly similar to others e.g. CAC08380.1 (253 aa); CCDA_BACSU|P45706 cytochrome C-type biogenesis protein from Bacillus subtilis (235 aa), FASTA scores: opt: 307, E(): 7.4e-13, (30.4% identity in 237 aa overlap); etc. SEEMS TO BELONG TO THE DSBD SUBFAMILY. Note that previously known as ccsA. Q7U1U7 No intermediary metabolism and respiration Rv0527 NC_002945.3 Mycobrowser_v2 CDS 619455 621044 . + 0 Mb0541 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0541, -, len: 529 aa. Equivalent to Rv0528, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 529 aa overlap). Probable conserved transmembrane protein, equivalent (shorter 14 aa in N-terminus) to CAC31926.1|AL583925 conserved membrane protein from Mycobacterium leprae (542 aa). Also highly similar to Q49817|B2168_C2_237|S72902 hypothetical protein from Mycobacterium leprae (364 aa), FASTA scores: opt: 1846, E(): 0, (81.1% identity in 338 aa overlap); and Q49811|B2168_C1_194|S72891 hypothetical protein from Mycobacterium leprae (106 aa), FASTA scores: opt: 506,E(): 3.8e-26, (73.6% identity in 106 aa overlap). Also highly similar to CAC08381.1|AL392176 putative integral membrane protein from Streptomyces coelicolor (574 aa). Q7U1U6 No cell wall and cell processes Rv0528 NC_002945.3 Mycobrowser_v2 CDS 623943 625688 . + 0 Mb0545 PE_PGRS6a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb0545, PE_PGRS6a, len: 581 aa. Equivalent to 5' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (92.7% identity in 564 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts,PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a. Q7U1U2 No NC_002945.3 Mycobrowser_v2 CDS 625594 625821 . + 0 Mb0546 PE_PGRS6b PE-PGRS FAMILY PROTEIN [SECOND PART] Mb0546, PE_PGRS6b, len: 75 aa. Equivalent to 3' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b. No NC_002945.3 Mycobrowser_v2 CDS 736753 737460 . + 0 Mb0660 rplA 50s ribosomal protein l1 rpla Mb0660, rplA, len: 235 aa. Equivalent to Rv0641,len: 235 aa, from Mycobacterium tuberculosis strain H37Rv (99.6% identity in 235 aa overlap). Probable rplA, 50S ribosomal protein L1, equivalent to NP_302281.1|NC_002677 50S ribosomal protein L1 from Mycobacterium leprae (235 aa). Also highly similar to others e.g. P3625|RL1_STRGR 50s ribosomal protein L1 from Streptomyces griseus (240 aa), FASTA scores: opt: 1081, E(): 0, (72.2% identity in 230 aa overlap); etc. BELONGS TO THE L1P FAMILY OF RIBOSOMAL PROTEINS. X2BFN1,P59790 No information pathways Rv0641 NC_002945.3 Mycobrowser_v2 CDS 625717 626724 . - 0 Mb0547c fabH 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III FABH (BETA-KETOACYL-ACP SYNTHASE III) (KAS III) Mb0547c, fabH, len: 335 aa. Equivalent to Rv0533c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). fabH (alternate gene name: mtFabH), 3-oxoacyl-[acyl-carrier protein] synthase III (EC 2.3.1.41) (see citations below), highly similar to others e.g. Q54206|FABH from STREPTOMYCES GLAUCESCENS (333 aa), FASTA scores: opt: 1109, E(): 0, (51.4% identity in 333 aa overlap); FABH_ECOLI|P24249 3-oxoacyl-[acyl-carrier-protein] synthase III (317 aa),FASTA scores: opt: 666, E(): 0, (37.1% identity in 318 aa overlap); etc. BELONGS TO THE FABH FAMILY. Note that previously known as fabH. X2BF69,P0A575 No NC_002945.3 Mycobrowser_v2 CDS 626806 627684 . - 0 Mb0548c menA 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE MENA (DHNA-OCTAPRENYLTRANSFERASE) Mb0548c, menA, len: 292 aa. Equivalent to Rv0534c,len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Probable menA,1,4-dihydroxy-2-naphthoate octaprenyltransferase (EC 2.5.1.-), integral membrane protein, equivalent to Y13803|MLB1306_2|NP_302556.1 probable 4-dihydroxy-2-naphthoate octaprenyltransferase from Mycobacterium leprae (294 aa), FASTA scores: opt: 1509,E(): 0, (80.2% identity in 288 aa overlap). Also highly similar to others e.g. MENA_ECOLI|P32166|B3930 from Escherichia coli (308 aa), FASTA scores: opt: 495, E(): 2.9e-25, (36.3 identity in 289 aa overlap); etc. BELONGS TO THE MENA FAMILY. X2BFB9,P65651 No NC_002945.3 Mycobrowser_v2 CDS 652022 652747 . - 0 Mb0575c POSSIBLE BENZOQUINONE METHYLTRANSFERASE (METHYLASE) Mb0575c, -, len: 241 aa. Equivalent to Rv0560c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Possible benzoquinone methyltransferase (EC 2.1.1.-) (see citation below),similar to other hypothetical proteins and methyltransferases e.g. Q54300 METHYLTRANSFERASE (211 aa),FASTA scores: opt: 203, E(): 4.8e-07, (30.9% identity in 136 aa overlap). Similar to Rv3699, Rv1377c, Rv2675c, etc from Mycobacterium tuberculosis. Rv0560c can be induced by salicylate and para-amino-salicylate (PAS). Q7U1S0 No intermediary metabolism and respiration Rv0560c NC_002945.3 Mycobrowser_v2 CDS 627701 628495 . + 0 Mb0549 pnp PROBABLE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE PNP (MTA PHOSPHORYLASE) Mb0549, pnp, len: 264 aa. Equivalent to Rv0535,len: 264 aa, from Mycobacterium tuberculosis strain H37R,(100.0% identity in 264 aa overlap). Probable pnp,5'-methylthioadenosine phosphorylase (EC 2.4.2.28), highly similar to others e.g. CAB90972.1|AL355832 putative methylthioadenosine phosphorylase from Streptomyces coelicolor (280 aa); etc. Also similar to Rv3307|deoD PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE (EC 2.4.2.1) from Mycobacterium tuberculosis (268 aa). BELONGS TO THE PNP/MTAP FAMILY 2 OF PHOSPHORYLASES. Gene name could be inappropriate. Q7U1U1 No intermediary metabolism and respiration Rv0535 NC_002945.3 Mycobrowser_v2 CDS 754753 755136 . - 0 Mb0675c vapc6 possible toxin vapc6 Mb0675c, -, len: 127 aa. Equivalent to Rv0656c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Conserved hypothetical protein, showing similarity with proteins from Mycobacterium tuberculosis e.g. Rv2757c, Rv2546,etc. Q7U1J1 No virulence, detoxification, adaptation Rv0656c NC_002945.3 Mycobrowser_v2 CDS 628492 629532 . + 0 Mb0550 galE3 PROBABLE UDP-GLUCOSE 4-EPIMERASE GALE3 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE) Mb0550, galE3, len: 346 aa. Equivalent to Rv0536,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Possible galE3,UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar to CAB76986.1|AL159178 putative epimerase from Streptomyces coelicolor (334 aa); and similar to other epimerases e.g. NP_436775.1|NC_003078 putative NDP-glucose dehydrataseepimerase protein from Sinorhizobium meliloti (368 aa); AF143772|AF143772_7 GepiA from Mycobacterium avium strain 2151 (353 aa), FASTA scores: opt: 577, E(): 3.9e-29, (36.6% identity in 352 aa overlap); GALE_METJA|Q57664 putative UDP-glucose 4-epimerase (305 aa), FASTA scores: opt: 300, E(): 1.6e-12, (30.9% identity in 343 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3634c, Rv3784, etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY. Note that previously known as galE2. Q7U1U0 No NC_002945.3 Mycobrowser_v2 CDS 629542 630975 . - 0 Mb0551c PROBABLE INTEGRAL MEMBRANE PROTEIN Mb0551c, -, len: 477 aa. Equivalent to Rv0537c,len: 477 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 477 aa overlap). Probable integral membrane protein, showing weak similarity to YDNK_STRCO|P40180 hypothetical 41.2 kd protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 122,E(): 0.85, (28.2% identity in 373 aa overlap). Q7U1T9 No cell wall and cell processes Rv0537c NC_002945.3 Mycobrowser_v2 CDS 631284 632930 . + 0 Mb0552 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0552, -, len: 548 aa. Equivalent to Rv0538, len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Possible conserved membrane protein. Middle region highly similar to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein from Mycobacterium bovis (295 aa) possible transmembrane protein with a repetitive proline, threonine-rich region at C-terminus. Q7U1T8 No cell wall and cell processes Rv0538 NC_002945.3 Mycobrowser_v2 CDS 632987 633619 . + 0 Mb0553 PROBABLE DOLICHYL-PHOSPHATE SUGAR SYNTHASE (DOLICHOL-PHOSPHATE SUGAR SYNTHETASE) (DOLICHOL-PHOSPHATE SUGAR TRANSFERASE) (SUGAR PHOSPHORYLDOLICHOL SYNTHASE) Mb0553, -, len: 210 aa. Equivalent to Rv0539, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Probable dolichol-P-sugar synthase (EC 2.4.1.-), highly similar to CAB76989.1|AL159178 putative glycosyltransferase from Streptomyces coelicolor (242 aa), and similar to various dolichol-P-sugar synthetases and sugar transferases e.g. NP_126257.1|NC_000868 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED PROTEIN from Pyrococcus abyssi (211 aa); N-terminus of NP_127133.1|NC_000868 DOLICHOL-P-GLUCOSE SYNTHETASE from Pyrococcus abyssi (378 aa); N-terminus of NP_068880.1|NC_000917 putative dolichol-P-glucose synthetase from Archaeoglobus fulgidus (369 aa), FASTA scores: E(): 2.4e-13, (32. 1% identity in 193 aa overlap); Q26732 DOLICHYL-PHOSPHATE-MANNOSE SYNTHASE PRECURSOR from TRYPANOSOMA BRUCEI (267 aa), FASTA scores: opt: 179, E(): 0.0011, (30.7% identity in 205 aa overlap); etc. Also similar to Rv2051c|MTY25D10_18 from Mycobacterium tuberculosis. Contains S00017 ATP/GTP-binding site motif A (P-loop). X2BFC3,P0A598 No intermediary metabolism and respiration Rv0539 NC_002945.3 Mycobrowser_v2 CDS 633616 634278 . + 0 Mb0554 CONSERVED HYPOTHETICAL PROTEIN Mb0554, -, len: 220 aa. Equivalent to Rv0540, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Streptomyces coelicolor: CAB76990.1|AL159178 (213 aa); N-terminus of BAA84086.1|AB032065 (446 aa); and CAB61872.1|AL133252|SCE46_21 (210 aa), FASTA scores: opt: 267, E(): 5.3e-10, (32.7% identity in 202 aa overlap). Also some similarity with D90913_63|PCC6803 from Synecho cystis sp (211 aa), FASTA scores: opt: 189, E(): 4.7e-06,(25.3 identity in 194 aa overlap). Q7U1T7 No conserved hypotheticals Rv0540 NC_002945.3 Mycobrowser_v2 CDS 634299 635648 . - 0 Mb0555c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0555c, -, len: 449 aa. Equivalent to Rv0541c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 449 aa overlap). Probable conserved integral membrane protein, highly similar (except first 40 residues) to CAB76994.1|AL159178 putative integral membrane protein from Streptomyces coelicolor (456 aa). Also some similarity to Q13724|GCS1_HUMAN MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (834 aa), FASTA scores: opt: 150, E(): 0.013, (27.1% identity in 339 aa overlap). Contains PS00041 Bacterial regulatory proteins,araC family signature. Q7U1T6 No cell wall and cell processes Rv0541c NC_002945.3 Mycobrowser_v2 CDS 635660 636748 . - 0 Mb0556c menE POSSIBLE O-SUCCINYLBENZOIC ACID--COA LIGASE MENE (OSB-COA SYNTHETASE) (O-SUCCINYLBENZOATE-COA SYNTHASE) Mb0556c, menE, len: 362 aa. Equivalent to Rv0542c,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 362 aa overlap). Possible menE,O-succinylbenzoic acid-CoA ligase (EC 6.2.1.26), highly similar to Q50170|AAA63145.1|U15187|XCLB 4-Coumarate--CoA ligase from Mycobacterium leprae (352 aa), FASTA scores: opt: 1815, E(): 0, (78.9% identity in 351 aa overlap). Also similar to N-terminus of acid-CoA ligases e.g. NP_471116.1|NC_003212 O-succinylbenzoic acid-CoA ligase from Listeria innocua (469 aa); NP_390957.1|NC_000964 O-succinylbenzoic acid-CoA ligase from Bacillus subtilis (486 aa); MENE_HAEIN|P44565 O-succinylbenzoic acid-CoA ligase from Haemophilus influenzae (452 aa), FASTA scores: opt: 307, E(): 4.6e-12, (25.4% identity in 339 aa overlap); etc. Also some similarity with fadD proteins from Mycobacterium tuberculosis. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U1T5 No NC_002945.3 Mycobrowser_v2 CDS 637179 637457 . - 0 Mb0558c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0558c, -, len: 92 aa. Equivalent to Rv0544c, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Possible conserved transmembrane protein, equivalent to NP_302470.1|NC_002677 possible membrane protein from Mycobacterium leprae (96 aa); and shows some similarity to MLU15187_33|Q50172|U296V from Mycobacterium leprae (36 aa), FASTA scores: opt: 151,E(): 2.1e-05, (71.4% identity in 35 aa overlap). Also some similarity with VATL_NEPNO|Q26250 vacuolar ATP synthase 16 kd proteolipid from Nephrops norvegicus (159 aa), FASTA scores: opt: 80, E(): 11, (26.1% identity in 88 aa overlap). Q7U1T3 No cell wall and cell processes Rv0544c NC_002945.3 Mycobrowser_v2 CDS 637454 638707 . - 0 Mb0559c pitA PROBABLE LOW-AFFINITY INORGANIC PHOSPHATE TRANSPORTER INTEGRAL MEMBRANE PROTEIN PITA Mb0559c, pitA, len: 417 aa. Equivalent to Rv0545c,len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 417 aa overlap). Probable pitA,low-affinity inorganic phosphate transporter, integral membrane protein, equivalent to Q50173|NP_302471.1 pitA from Mycobacterium leprae (414 aa), FASTA scores: opt: 2035, E(): 0, (76.3% identity in 418 aa overlap). Also highly similar to others e.g. CAB59461.1|AL132644 putative low-affinity phosphate transport protein from Streptomyces coelicolor (423 aa); PITA_ECOLI|P37308 low-affinity inorganic phosphate transporter from Escherichia coli (499 aa), FASTA scores: opt: 304, E(): 6.9e-10, (32.5 % identity in 234 aa overlap); etc. BELONGS TO THE PHO-4 FAMILY OF TRANSPORTERS, PIT SUBFAMILY. X2BFE2,P59950 No NC_002945.3 Mycobrowser_v2 CDS 649779 650915 . + 0 Mb0572 mgta mannosyltransferase mgta Mb0572, pimB, len: 378 aa. Equivalent to Rv0557,len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). pimB (alternate gene name: mtfB), mannosyltransferase (EC 2.4.1.-) (see citation below), similar to other various transferases e.g. NP_243554.1|NC_002570 alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans (381 aa); NP_249533.1|NC_002516 probable glycosyl transferase from Pseudomonas aeruginosa (406 aa); NP_419573.1|NC_002696 glycosyl transferase, group 1 family protein, from Caulobacter crescentus (455 aa); etc. Also similar to Q55598 hypothetical 44.9 kDa protein from SYNECHOCYSTIS SP (409 aa), FASTA scores: opt: 703, E(): 0,(33.9% identity in 378 aa overlap); GPI3_YEAST|P32363 n-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (452 aa), FASTA scores: opt: 230, E(): 1.1e-07,(23.5% identity in 328 aa overlap). Q7U1S2 No lipid metabolism Rv0557 NC_002945.3 Mycobrowser_v2 CDS 638827 639213 . - 0 Mb0560c conserved protein Mb0560c, -, len: 128 aa. Equivalent to Rv0546c,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, equivalent to AAA63111.1|U15187|Q50174|U296X hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 748,E(): 0, (84.2% identity in 133 aa overlap). Also highly similar to CAB95979.1|AL360034 conserved hypothetical protein from Streptomyces coelicolor (130 aa); and similar to AE000854_8|O26852 S-D-LACTOYLGLUTATHIONE METHYLGLYOXAL LYASE from Methanobacterium thermoautotropto (116 aa),FASTA scores: opt: 155, E(): 0.00019, (30.6% identity in 108 aa overlap); YAER_ECOLI hypothetical 14.7 kd protein from Escherichia coli (129 aa), FASTA scores: opt: 104,E(): 0.42, (28.7% identity in 115 aa overlap). Also similar to Rv2068c from Mycobacterium tuberculosis. Q7U1T2 No conserved hypotheticals Rv0546c NC_002945.3 Mycobrowser_v2 CDS 639276 640160 . - 0 Mb0561c POSSIBLE OXIDOREDUCTASE Mb0561c, -, len: 294 aa. Equivalent to Rv0547c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases e.g. fatty acyl-CoA reductase from Acinetobacter calcoaceticus (295 aa); NP_280196.1|NC_002607 3-oxoacyl-[acyl-carrier-protein] reductase from Halobacterium sp. NRC-1 (255 aa); NP_349214.1|NC_003030 Short-chain alcohol dehydrogenase family protein from Clostridium acetobutylicum (255 aa); etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Y04M_MYCTU|Q10783 putative oxidoreductase (341 aa), FASTA scores: opt: 644, E(): 0,(46.1% identity in 258 aa overlap). Q7U1T1 No intermediary metabolism and respiration Rv0547c NC_002945.3 Mycobrowser_v2 CDS 640256 641200 . - 0 Mb0562c menB naphthoate synthase menb (dihydroxynaphthoic acid synthetase) (dhna synthetase) Mb0562c, menB, len: 314 aa. Equivalent to Rv0548c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable menB,naphthoate synthase (dihydroxynaphthonic acid synthase) (EC 4.1.3.36), equivalent to NP_302473.1|NC_002677 naphthoate synthase from Mycobacterium leprae (300 aa). Also similar to others e.g. MENB_ECOLI|P27290 naphthoate synthase from Escherichia coli (285 aa), FASTA scores: opt: 599, E(): 9.3e-33, (48.1 identity in 285 aa overlap); etc. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Q7U1T0 No NC_002945.3 Mycobrowser_v2 CDS 641472 641609 . - 0 Mb0563c vapc3 CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb0563c, -, len: 45 aa. Similar to 3' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 45 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065,and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c. No NC_002945.3 Mycobrowser_v2 CDS 693129 693272 . + 0 Mb0608 mce2Db MCE-FAMILY PROTEIN MCE2DB [SECOND PART] Mb0608, mce2Db, len: 47 aa. Equivalent to 3' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (95.7% identity in 47 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db. No NC_002945.3 Mycobrowser_v2 CDS 642339 644054 . - 0 Mb0566c fadD8 PROBABLE FATTY-ACID-COA LIGASE FADD8 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0566c, fadD8, len: 571 aa. Equivalent to Rv0551c,len: 571 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 571 aa overlap). Probable fadD8,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 585, E(): 9.5e-30, (28.7% identity in 536 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Note other possible start sites exist downstream of this start. Q7U1S7 No NC_002945.3 Mycobrowser_v2 CDS 644132 645736 . + 0 Mb0567 conserved protein Mb0567, -, len: 534 aa. Equivalent to Rv0552, len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 534 aa overlap). Conserved hypothetical protein, similar to others from several organisms. Also shows some similarity with regulatory proteins e.g. AEPA_ERWCA|Q06555 exoenzymes regulatory protein aepA [Precursor] from Erwinia carotovora (465 aa),FASTA scores: opt: 278, E(): 7.6e-11, (23.0% identity in 408 aa overlap). Also similar to Z99119|BSUB0016_28 from Bacillus subtilis (529 aa), FASTA scores: opt: 436, E(): 8.3e-20, (23.8% identity in 547 aa overlap). C-terminus is similar to MLRRNOPR_1 HYPOTHETICAL 17.7 KD PROTEIN from Mycobacterium leprae (154 aa), FASTA score: (43.1% identity in 160 aa overlap). Q7U1S6 No conserved hypotheticals Rv0552 NC_002945.3 Mycobrowser_v2 CDS 645733 646713 . + 0 Mb0568 menC PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE) Mb0568, menC, len: 326 aa. Equivalent to Rv0553,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 326 aa overlap). Probable menC,muconate cycloisomerase (EC 5.5.1.1), equivalent to NP_302476.1|NC_002677 putative isomerase/racemase from Mycobacterium leprae (334 aa). Also similar to other muconate cycloisomerases e.g. TCBD_PSESP|P27099 chloromuconate cycloisomerase (370 aa), FASTA scores: opt: 249, E(): 7.8e-09, (32.7% identity in 199 aa overlap). Also similar to O-succinylbenzoate-CoA synthases. BELONGS TO THE MANDELATE RACEMASE / MUCONATE LACTONIZING ENZYME FAMILY. X2BFD4,P65426 No intermediary metabolism and respiration Rv0553 NC_002945.3 Mycobrowser_v2 CDS 646710 647498 . + 0 Mb0569 bpoC POSSIBLE PEROXIDASE BPOC (NON-HAEM PEROXIDASE) Mb0569, bpoC, len: 262 aa. Equivalent to Rv0554,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Possible bpoC,peroxidase (non-haem peroxidase) (EC 1.11.1.-), equivalent to NP_302477.1|NC_002677 putative hydrolase from Mycobacterium leprae (265 aa). Also highly similar or similar to various hydrolases and peroxidases e.g. CAB38877.1|AL035707|T36181 probable hydrolase from Streptomyces coelicolor (272 aa); CAC48368.1|Y16952 putative hydrolase from Amycolatopsis mediterranei (284 aa); P29715|BPA2_STRAU non-haem bromoperoxidase bpo-a2 (bromide peroxidase) (EC 1.11.1.-) from Streptomyces aureofaciens (277 aa), FASTA scores: opt: 325, E(): 2.3e-15, (29.5% identity in 268 aa overlap); O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase (chloride peroxidase) (EC 1.11.1.10) from Streptomyces aureofaciens (278 aa); etc. Also similar to M. tuberculosis non-heme haloperoxidases and epoxide hydrolases e.g. Rv1938, Rv3617, etc. Q7U1S5 No virulence, detoxification, adaptation Rv0554 NC_002945.3 Mycobrowser_v2 CDS 650932 651636 . + 0 Mb0573 menH PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase) Mb0573, menH, len: 234 aa. Equivalent to Rv0558,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable menH (alternate gene name: menG), ubiquinone/menaquinone biosynthesis methlytransferase (2-heptaprenyl-1,4-naphthoquinone methyltransferase) (EC 2.1.1.-), equivalent to NP_302480.1|NC_002677 putative ubiquinone/menaquinone biosynthesis methyltransferase from Mycobacterium leprae (238 aa). Also highly similar to others e.g. CAB44537.1|AL078618|T34630 from Streptomyces coelicolor (231 aa); UBIE_ECOLI|P27851 from Escherichia coli strain K12 (251 aa), FASTA scores: opt: 421, E(): 1.2e-21, (43.2% identity in 227 aa overlap); GRC2_BACSU|P31113 from Bacillus subtilis (233 aa), FASTA scores: opt: 345, E(): 1.4e-16, (34.6% identity in 231 aa overlap); etc. BELONGS TO THE UBIE FAMILY. Note that previously known as ubiE. X2BFD8,P0A639 No intermediary metabolism and respiration Rv0558 NC_002945.3 Mycobrowser_v2 CDS 651650 651988 . - 0 Mb0574c POSSIBLE CONSERVED SECRETED PROTEIN Mb0574c, -, len: 112 aa. Equivalent to Rv0559c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Possible conserved secreted protein, similar to NP_302481.1|NC_002677 putative secreted protein from Mycobacterium leprae (112 aa). Also similar to Y08B_MYCTU|Q11048 hypothetical 11.6 kd protein FASTA scores: opt: 111, E(): 011, (25.4% identity in 114 aa overlap). Contains possible N-terminal signal sequence. Q7U1S1 No cell wall and cell processes Rv0559c NC_002945.3 Mycobrowser_v2 CDS 760301 760573 . + 0 Mb0683 vapb8 possible antitoxin vapb8 Mb0683, -, len: 90 aa. Equivalent to Rv0664, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein. Q7U1I3 No virulence, detoxification, adaptation Rv0664 NC_002945.3 Mycobrowser_v2 CDS 652772 653998 . - 0 Mb0576c POSSIBLE OXIDOREDUCTASE Mb0576c, -, len: 408 aa. Equivalent to Rv0561c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar (except in first 30 aa) to NP_302482.1|NC_002677 putative FAD-linked oxidoreductase from Mycobacterium leprae (408 aa). Also similar to T34627 probable electron transfer oxidoreductase from Streptomyces coelicolor (430 aa); and some bacteriochlorophyll synthases e.g. NP_069300.1|NC_000917 bacteriochlorophyll synthase from Archaeoglobus fulgidus (410 aa); Q55087 GERANYLGERANYL HYDROGENASE (407 aa), FASTA scores: opt: 208, E(): 1.7e-06, (26.9% identity in 327 aa overlap). Q7U1R9 No intermediary metabolism and respiration Rv0561c NC_002945.3 Mycobrowser_v2 CDS 654014 655021 . + 0 Mb0577 grcC1 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) Mb0577, grcC1, len: 335 aa. Equivalent to Rv0562,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Probable grcC1,polyprenyl diphosphate synthetase (EC 2.5.1.-), equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (325 aa); Rv3383c,Rv3398c, etc. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY. Q7U1R8 No NC_002945.3 Mycobrowser_v2 CDS 705997 707154 . - 0 Mb0627c HYPOTHETICAL PROTEIN Mb0627c, -, len: 385 aa. Equivalent to Rv0610c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 385 aa overlap). Hypothetical unknown protein. Q7U1M6 No conserved hypotheticals Rv0610c NC_002945.3 Mycobrowser_v2 CDS 655122 655982 . + 0 Mb0578 htpX PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX Mb0578, htpX, len: 286 aa. Equivalent to Rv0563,len: 286 aa (alternative start at position 654006), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 286 aa overlap). Probable htpX, protease heat shock protein X (EC 3.4.24.-) (transmembrane protein),equivalent to NP_302484.1|NC_002677 putative peptidase from Mycobacterium leprae (287 aa). Also highly similar to others e.g. CAC08262.1|AL392146 putative peptidase from Streptomyces coelicolor (287 aa); NP_387431.1|NC_003047 PUTATIVE PROTEASE TRANSMEMBRANE PROTEIN from Sinorhizobium meliloti (319 aa); NP_105051.1|NC_002678 heat shock protein (htpX) from Mesorhizobium loti (336 aa); NP_248692.1|NC_000909|U67608|MJU67608_8 heat shock protein HtpX, possibly protease (htpX) from Methanococcus jannaschii (284 aa), FASTA scores: opt: 660, E(): 0, (46.5 identity in 245 aa overlap). Continuation of MTCY25D10.42. TBparse score is 0.887. BELONGS TO PEPTIDASE FAMILY M48 (ZINC METALLOPROTEASE). COFACTOR: Zinc. X2BFE3,P65816 No virulence, detoxification, adaptation Rv0563 NC_002945.3 Mycobrowser_v2 CDS 656167 657192 . - 0 Mb0579c gpdA1 PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA1 (NAD(P)H-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) (NAD(P)H-DEPENDENT DIHYDROXYACETONE-PHOSPHATE REDUCTASE) Mb0579c, gpdA1, len: 341 aa. Equivalent to Rv0564c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 341 aa overlap). Possible gpdA1(alternate gene names: gpsA, glyC),glycerol-3-phosphate dehydrogenase [NAD(P)+] dependant (EC 1.1.1.94), similar to many other glycerol-3-phosphate dehydrogenases e.g. P46919|GPDA_BACSU from Bacillus subtilis (345 aa), FASTA scores: opt: 731, E(): 0, (37.3% identity in 332 aa overlap); etc. Also similar to Rv2982c|gpdA2|MTCY349.05|Z83018|MTCY349_5 from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 740, E(): 0, (40.4% identity in 322 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY. X2BFG8,P64189 No NC_002945.3 Mycobrowser_v2 CDS 760570 760908 . + 0 Mb0684 vapc8 possible toxin vapc8 Mb0684, -, len: 112 aa. Equivalent to Rv0665, len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Conserved hypothetical protein, similar to Rv0627 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), and showing similarity with Rv0595c. Q7U1I2 No virulence, detoxification, adaptation Rv0665 NC_002945.3 Mycobrowser_v2 CDS 657253 658713 . - 0 Mb0580c PROBABLE MONOOXYGENASE Mb0580c, -, len: 486 aa. Equivalent to Rv0565c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 486 aa overlap). Probable monoxygenase (EC 1.14.-.-), highly similar to NP_301173.1|NC_002677 putative monooxygenase from Mycobacterium leprae (494 aa). Also highly similar to others e.g. NP_421371.1|NC_002696 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa); C-terminus of NP_051574.1|NC_000958 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa); P12015|CYMO_ACISP CYCLOHEXANONE MONOOXYGENASE (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: opt: 354, E(): 2.1e-16, (23.7% identity in 435 aa overlap); etc. Also similar to other putative monoxygenases from Mycobacterium tuberculosis e.g. Rv3854c (489 aa), MTCY01A6.14 (489 aa), MTV013_4 (495 aa),MTCY31.20 (495 aa). Q7U1R7 No intermediary metabolism and respiration Rv0565c NC_002945.3 Mycobrowser_v2 CDS 658791 659282 . - 0 Mb0581c conserved protein Mb0581c, -, len: 163 aa. Equivalent to Rv0566c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to others e.g. P77482|YAJQ_ECOLI HYPOTHETICAL 19.0 KDa PROTEIN from Escherichia coli (169 aa), FASTA scores: opt: 422, E(): 5.4e-20, (44.1 identity in 161 aa overlap); etc. X2BFI9 No conserved hypotheticals Rv0566c NC_002945.3 Mycobrowser_v2 tRNA 659352 659432 . + 0 tyrT tyrT tRNA-Tyr tyrT, len: 81 nt. Equivalent to tyrT, len: 81 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 81 nt overlap). tRNA-Tyr, anticodon gta,length = 81 No NC_002945.3 Mycobrowser_v2 CDS 659564 660583 . + 0 Mb0582 PROBABLE METHYLTRANSFERASE/METHYLASE Mb0582, -, len: 339 aa. Equivalent to Rv0567, len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 339 aa overlap). Probable methyltransferase (EC 2.1.1.-), similar to several e.g. P39896|TCMO_STRGA TETRACENOMYCIN POLYKETIDE SYNTHESIS 8-O-METHYLTRANSFERASE from Streptomyces glaucescens (339 aa), FASTA scores: opt: 685, E(): 0, (35.8% identity in 335 aa overlap); P10950|HIOM_BOVIN HYDROXYINDOLE O-METHYLTRANSFERASE (EC 2.1.1.4) from Bos taurus (345 aa),FASTA scores: opt: 509, E(): 3.4e-27, (30.7% identity in 332 aa overlap) etc. Q7U1R6 No intermediary metabolism and respiration Rv0567 NC_002945.3 Mycobrowser_v2 CDS 683128 685515 . - 0 Mb0600c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0600c, -, len: 795 aa. Equivalent to Rv0585c,len: 795 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 795 aa overlap). Probable conserved integral membrane protein. C-terminus similar to CAB88984.1|AL353864 putative integral membrane protein from Streptomyces coelicolor (299 aa); and C-terminal region of CAC01311.1|AL390968 putative integral membrane protein from Streptomyces coelicolor (925 aa). Also some similarity with Rv0204 from Mycobacterium tuberculosis. Q7U1Q0 No cell wall and cell processes Rv0585c NC_002945.3 Mycobrowser_v2 CDS 704731 705132 . + 0 Mb0625 vapc28 possible toxin vapc28. contains pin domain. Mb0625, -, len: 133 aa. Equivalent to Rv0609, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to several Mycobacterium tuberculosis hypothetical proteins e.g. YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37 CONSERVED HYPOTHETICAL PROTEIN (139 aa), FASTA scores: opt: 262,E(): 8.1e-12, (39.1% identity in 128 aa overlap); MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05 CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA score: (42.9% identity in 126 aa overlap), Rv0565c, Rv3854c, etc. X2BFL4,P67239 No virulence, detoxification, adaptation Rv0609 NC_002945.3 Mycobrowser_v2 CDS 660693 662111 . + 0 Mb0583 cyp135B1 POSSIBLE CYTOCHROME P450 135B1 CYP135B1 Mb0583, cyp135B1, len: 472 aa. Equivalent to Rv0568, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 472 aa overlap). Possible cyp135B1, cytochrome P450 (EC 1.14.-.-), similar to putative cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. P29980|CPXN_ANASP PROBABLE CYTOCHROME P450 from Anabaena sp. strain PCC 7120 (459 aa), FASTA scores: opt: 525, E(): 7.2e-27, (31.9% identity in 417 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0327c|NP_214841.1|NC_000962|CYP135A1|MT0342|MTCY63.32c PUTATIVE CYTOCHROME P450 (449 aa), FASTA scores: opt: 1080, E(): 0, (40.5% identity in 444 aa overlap); Rv3685c|NP_218202.1|NC_000962 PUTATIVE CYTOCHROME P450 (476 aa); Rv0136|NP_214650.1|NC_000962 PUTATIVE CYTOCHROME P450 (441 aa); etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). X2BFF0,P63716 No intermediary metabolism and respiration Rv0568 NC_002945.3 Mycobrowser_v2 CDS 662246 662512 . + 0 Mb0584 conserved protein Mb0584, -, len: 88 aa. Equivalent to Rv0569, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Conserved hypothetical protein. C-terminus highly similar to AAA63065.1|U15184|MLU15184_10 hypothetical protein from Mycobacterium leprae (53 aa), FASTA scores: opt: 140, E(): 0.0046, (64.7% identity in 34 aa overlap). Also similar to T36824|SCI35.11 hypothetical protein from Streptomyces coelicolor (64 aa); and N-terminus of T36956 probable DNA-binding protein from Streptomyces coelicolor (323 aa). Also highly similar to Rv2302|MTCY339.07c|NP_216818.1|NC_000962 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (80 aa), FASTA scores: opt: 300, E(): 1.4e-13, (61.8% identity in 76 aa overlap). Q7U1R5 No conserved hypotheticals Rv0569 NC_002945.3 Mycobrowser_v2 CDS 662538 664670 . + 0 Mb0585 nrdZ PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (LARGE SUBUNIT) NRDZ (RIBONUCLEOTIDE REDUCTASE) Mb0585, nrdZ, len: 710 aa. Equivalent to 5' end of Rv0570, len: 692 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 631 aa overlap). Probable nrdZ, ribonucleoside-diphosphate reductase, large subunit (EC 1.17.4.-), highly similar to others e.g. NP_070492.1|NC_000917|NRD|AE000988_11 ribonucleotide reductase from Archaeoglobus fulgidus (752 aa), FASTA scores: opt: 2001, E(): 0, (52.5% identity in 562 aa overlap) (N-terminus shorter); U73619|TAU73619_1|T37459 ribonucleotide reductase from Thermoplasma acidophilum (857 aa), FASTA scores: opt: 1678, E(): 0, (43.7% identity in 723 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE LARGE CHAIN FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U1R4 No NC_002945.3 Mycobrowser_v2 CDS 664729 666060 . - 0 Mb0586c conserved protein Mb0586c, -, len: 443 aa. Equivalent to Rv0571c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 443 aa overlap). Conserved hypothetical protein, highly similar to the products of two adjacent orfs in Mycobacterium leprae: AAA63059.1|U15184|U650S|Q50111 hypothetical protein (258 aa), FASTA scores: opt: 1071, E(): 0, (72.5% identity in 233 aa overlap); and AAA63058.1|U15184|U650T hypothetical protein (86 aa), FASTA scores: opt: 192, E(): 6.4e-06,(70.8% identity in 48 aa overlap). Also similar to others e.g. NP_107072.1|NC_002678 hypothetical protein from Mesorhizobium loti (235 aa); NP_213031.1|NC_000918 hypothetical protein from Aquifex aeolicus (175 aa); etc. And similar to part of hypothetical proteins from Mycobacterium tuberculosis e.g. C-terminus of Rv2143|MTCY270.25c|Z95388|NP_216659.1|NC_000962 (352 aa),FASTA scores: opt: 592, E(): 7e-32, (49.3% identity in 205 aa overlap); N-terminus of Rv2030c|NP_216546.1|NC_000962 (681 aa). Q7U1R3 No conserved hypotheticals Rv0571c NC_002945.3 Mycobrowser_v2 CDS 666284 666625 . - 0 Mb0587c HYPOTHETICAL PROTEIN Mb0587c, -, len: 113 aa. Equivalent to Rv0572c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 113 aa overlap). Hypothetical unknown protein. Q7U1R2 No conserved hypotheticals Rv0572c NC_002945.3 Mycobrowser_v2 CDS 667093 668484 . - 0 Mb0588c pncb2 nicotinic acid phosphoribosyltransferase pncb2 Mb0588c, -, len: 463 aa. Equivalent to Rv0573c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins and some nicotinate phosphoribosyltransferases e.g. NP_213718.1|NC_000918 hypothetical protein from Aquifex aeolicus (426 aa); AL109962|T36953|SCJ1.20 conserved hypothetical protein from Streptomyces coelicolor (438 aa), FASTA scores: opt: 1089, E(): 0, (49.4% identity in 385 aa overlap); P_391053.1|Z99120|BSUB0017_57|NC_000964 protein similar to nicotinate phosphoribosyltransferase from Bacillus subtilis (490 aa), FASTA scores: opt: 955, E():0, (43.5% identity in 356 aa overlap); etc. Also similar to Q10641|Y03F_MYCTU|MTCY130.15c|Rv1330c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (509 aa), FASTA scores: opt: 761, E(): 0, (38.4% identity in 437 aa overlap). Q7U1R1 No intermediary metabolism and respiration Rv0573c NC_002945.3 Mycobrowser_v2 CDS 668494 669636 . - 0 Mb0589c CONSERVED HYPOTHETICAL PROTEIN Mb0589c, -, len: 380 aa. Equivalent to Rv0574c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Conserved hypothetical protein, showing similarity with other hypothetical proteins and polyglutamate synthases (encapsulation proteins) e.g. AAK64444.1|AF377339_5|AF377339 polyglutamate synthase CapA from Myxococcus xanthus (405 aa); M24150|BACCAPABC_3|CapA polyglutamate synthase (encapsulation protein) from B.anthracis (411 aa), FASTA scores: opt: 261, E(): 4.3e-10, (25.8% identity in 287 aa overlap); etc. Q7U1R0 No conserved hypotheticals Rv0574c NC_002945.3 Mycobrowser_v2 CDS 669852 670988 . - 0 Mb0590c POSSIBLE OXIDOREDUCTASE Mb0590c, -, len: 378 aa. Equivalent to 5' end of Rv0575c, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 346 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786,E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 SALICYLATE HYDROXYLASE from SPHINGOMONAS (395 aa), FASTA scores: opt: 267, E():5e-11, (26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U1Q9 No NC_002945.3 Mycobrowser_v2 CDS 671091 672395 . + 0 Mb0591 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY) Mb0591, -, len: 434 aa. Equivalent to Rv0576, len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 434 aa overlap). Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region (~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tuberculosis (107 aa). Contains helix-turn-helix motif at aa 23-43 (Score 1628, +4.73 SD). Q7U1Q8 No regulatory proteins Rv0576 NC_002945.3 Mycobrowser_v2 CDS 760905 761078 . + 0 Mb0685 POSSIBLE MEMBRANE PROTEIN Mb0685, -, len: 57 aa. Equivalent to Rv0666, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Possible membrane protein; has hydrophobic stretch at aa 29-47. Q7U1I1 No cell wall and cell processes Rv0666 NC_002945.3 Mycobrowser_v2 CDS 672409 673194 . + 0 Mb0592 TB27.3 conserved protein tb27.3 Mb0592, TB27.3, len: 261 aa. Equivalent to Rv0577,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). TB27.3, conserved hypothetical protein. Corresponds to O53774|CF30_MYCTU 27 KD ANTIGEN CFP30B from Mycobacterium tuberculosis culture filtrate (260 aa), FASTA scores: opt: 1781, E(): 0,(100.0% identity in 260 aa overlap). Also similar to several hypothetical proteins and hydroxylases from Steptomyces sp. e.g. T35032 probable hydroxylase from Streptomyces coelicolor (263 aa); Q55078 orfA gene product from Streptomyces sp. (275 aa), FASTA scores: E(): 1.5e-1 9, (38.6% identity in 264 aa overlap); D89734_1|P95754 DNA for SgaA SGAA PROTEIN from Streptomyces griseus; and SC9B10_20 from Streptomyces coelicolor (267 aa), FASTA score: (38.9 identity in 252 aa overlap). Also similar to Rv0911|MTCY21C12.05 from Mycobacterium tuberculosis (257 aa), FASTA scores: E(): 1.1e-20, (32.0% identity in 259 aa overlap). X2BFF7 No NC_002945.3 Mycobrowser_v2 CDS 685653 686375 . + 0 Mb0601 mce2r probable transcriptional regulatory protein mce2r (gntr-family) Mb0601, -, len: 240 aa. Equivalent to Rv0586, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable transcriptional regulator, GntR family, similar to many e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase operon regulatory protein from Escherichia coli (258 aa),FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in 232 aa overlap); etc. Also similar to other M. tuberculosis transcriptional regulators GntR proteins e.g. Rv3060c, Rv0792c, etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature and probable helix-turn helix motif from aa 35-56 (Score 1531, +4.40 SD). X2BFB8,P67742 No regulatory proteins Rv0586 NC_002945.3 Mycobrowser_v2 CDS 673239 677159 . - 0 Mb0593c PE_PGRS7 pe-pgrs family protein pe_pgrs7 Mb0593c, PE_PGRS7, len: 1306 aa. Equivalent to Rv0578c, len: 1306 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1306 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many other PGRS proteins e.g. MTCY493.04|Z95844 from M. tuberculosis (1329 aa), FASTA scores: opt: 3994, E(): 0,(54.6% identity in 1375 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures possibly fortuitously. Q7U1Q7 No NC_002945.3 Mycobrowser_v2 CDS 677481 678239 . + 0 Mb0594 CONSERVED HYPOTHETICAL PROTEIN Mb0594, -, len: 252 aa. Equivalent to Rv0579, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Conserved hypothetical protein, showing some similarity to others e.g. AE001747_4 hypothetical protein from Thermotoga maritima (247 aa), FASTA scores: opt: 612, E(): 0, (39.6% identity in 235 aa overlap); AE001004_2 hypothetical protein from Archaeoglobus fulgidus (159 aa), FASTA scores: opt: 196, E(): 1e-06, (28.3% identity in 159 aa overlap); etc. Q7U1Q6 No conserved hypotheticals Rv0579 NC_002945.3 Mycobrowser_v2 CDS 678368 678859 . - 0 Mb0595c conserved protein Mb0595c, -, len: 163 aa. Equivalent to Rv0580c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, equivalent to AAA90989.1|U20446|MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa). TBparse score is 0.910. Q7U1Q5 No conserved hypotheticals Rv0580c NC_002945.3 Mycobrowser_v2 CDS 678953 679168 . + 0 Mb0596 vapb26 possible antitoxin vapb26 Mb0596, -, len: 71 aa. Equivalent to Rv0581, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Conserved hypothetical protein, showing weak similarity to several Mycobacterium tuberculosis proteins including P95003|Z83863|Rv2550c|MTCY159_6 CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA scores: opt: 93, E(): 3.2, (25.7% identity in 70 aa overlap); Rv2871; Rv1241; etc. Also shows weak similarity to X05648|SGSPH_1 from Streptomyces glaucescens (77 aa), FASTA scores: opt: 92, E(): 3.6,(35.4% identity in 65 aa overlap). Q7U1Q4 No virulence, detoxification, adaptation Rv0581 NC_002945.3 Mycobrowser_v2 CDS 679165 679572 . + 0 Mb0597 vapc26 possible toxin vapc26. contains pin domain. Mb0597, -, len: 135 aa. Equivalent to Rv0582, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Hypothetical unknown protein. Q7U1Q3 No virulence, detoxification, adaptation Rv0582 NC_002945.3 Mycobrowser_v2 CDS 679632 680318 . - 0 Mb0598c lpqN PROBABLE CONSERVED LIPOPROTEIN LPQN Mb0598c, lpqN, len: 228 aa. Equivalent to Rv0583c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Probable lpqN,conserved lipoprotein, equivalent to AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein precursor from Mycobacterium kansasii (225 aa), FASTA scores: opt: 945, E(): 0, (62.7% identity in 228 aa overlap); and similar to others from Mycobacteria e.g. Rv0040c and Rv1016c from Mycobacterium tuberculosis. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U1Q2 No NC_002945.3 Mycobrowser_v2 CDS 680472 683105 . + 0 Mb0599 POSSIBLE CONSERVED EXPORTED PROTEIN Mb0599, -, len: 877 aa. Equivalent to Rv0584, len: 877 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 877 aa overlap). Possible conserved exported protein, similar to other hypothetical proteins which are not necessarily secreted e.g. CAB61925.1|AL133278 putative secreted protein from Streptomyces coelicolor (772 aa); AAD51075.1|AF175722_1|AF175722 immunoreactive 89kD antigen PG87 from Porphyromonas gingivalis (781 aa), FASTA scores: opt: 637, E(): 2.1e-30, (29.1% identity in 794 aa overlap); etc. Contains PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. Has potential N-terminal signal peptide. Q7U1Q1 No cell wall and cell processes Rv0584 NC_002945.3 Mycobrowser_v2 CDS 707206 707589 . - 0 Mb0628c HYPOTHETICAL PROTEIN Mb0628c, -, len: 127 aa. Equivalent to Rv0611c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Hypothetical unknown protein. Note that first start has been taken although this overlaps slightly with the upstream ORF. Q7U1M5 No conserved hypotheticals Rv0611c NC_002945.3 Mycobrowser_v2 CDS 686372 687169 . + 0 Mb0602 yrbE2A CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE2A Mb0602, yrbE2A, len: 265 aa. Equivalent to Rv0587,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). yrbE2A, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 311, E(): 1.8e-83, (24.2% identity in 265 aa overlap); NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); etc. Q7U1P9 No NC_002945.3 Mycobrowser_v2 CDS 687171 688058 . + 0 Mb0603 yrbE2B CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE2B Mb0603, yrbE2B, len: 295 aa. Equivalent to Rv0588,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). yrbE2B, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kd protein from Escherichia coli (260 aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 % identity in 267 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protei from Haemophilus influenzae (261 aa),FASTA scores: opt: 234, E(): 6.3e-08, (24.2% identity in 215 aa overlap); NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); etc. Q7U1P8 No NC_002945.3 Mycobrowser_v2 CDS 688064 689278 . + 0 Mb0604 mce2A MCE-FAMILY PROTEIN MCE2A Mb0604, mce2A, len: 404 aa. Equivalent to Rv0589,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 404 aa overlap). mce2A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Also highly similar, but longer 21 aa, to P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1324, E(): 0, (62.6% identity in 436 aa overlap). Contains a possible N-terminal signal or anchor sequence. Note that previously known as mce2. Q7U1P7 No NC_002945.3 Mycobrowser_v2 CDS 689275 690306 . + 0 Mb0605 mce2B mce-family related protein Mb0605, mce2B, len: 343 aa. Equivalent to Rv0590 and Rv0590A, len: 275 aa and 84 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 255 aa overlap and 100.0% identity in 84 aa overlap). mce2B: belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); P45391|YRBD_ECOLI hypothetical 19.6 kd protein from Escherichia coli (183 aa), FASTA scores: opt: 160, E(): 0.00099, (28.3% identity in 166 aa overlap); P45029|YRBD_HAEIN|HI1085 hypothetical protein from Haemophilus influenzae (167 aa), FASTA scores: opt: 135,E():0.035, (25.9% identity in 143 aa overlap); etc. Contains possible N-terminal signal or anchor sequence. Rv0590A: probable continuation of mce2B|Rv0590. Can find no frameshift to account for this. Possible nucleotide G missing at 688793 as there are 5 in Mycobacterium bovis but only 4 in CDC1551. Strong similarity to C-terminus of other Mce proteins e.g. AL583926|AL583926_38 from Mycobacterium leprae strain TN (346 aa), FASTA scores: E(): 1.2e-20, (67.85% identity in 84 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes,most likely to be linked. In Mycobacterium bovis, an in-frame insertion of a single base (*-g) leads to a single product. Q7U1P6 No virulence, detoxification, adaptation Rv0590 NC_002945.3 Mycobrowser_v2 CDS 690303 691748 . + 0 Mb0606 mce2C MCE-FAMILY PROTEIN MCE2C Mb0606, mce2C, len: 481 aa. Equivalent to Rv0591,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 481 aa overlap). mce2C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and may contain N-terminal signal or anchor sequence. Has highly Pro-rich C-terminus. Q7U1P5 No NC_002945.3 Mycobrowser_v2 CDS 705075 705302 . + 0 Mb0626 CONSERVED HYPOTHETICAL PROTEIN Mb0626, -, len: 75 aa. Equivalent to Rv0609A, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Conserved hypothetical protein, highly similar to part of upstream ORF Rv0612|MTCY19H5.09c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (201 aa), FASTA scores: opt: 154, E(): 1.8e-05, (74.3% identity in 35 aa overlap). Q7U1M7 No conserved hypotheticals Rv0609A NC_002945.3 Mycobrowser_v2 CDS 691745 693181 . + 0 Mb0607 mce2Da MCE-FAMILY PROTEIN MCE2DA [FIRST PART] Mb0607, mce2Da, len: 478 aa. Equivalent to 5' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 471 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db. Q7U1P4 No NC_002945.3 Mycobrowser_v2 CDS 693269 693835 . + 0 Mb0609 lprL POSSIBLE MCE-FAMILY LIPOPROTEIN LPRL (MCE-FAMILY LIPOPROTEIN MCE2E) Mb0609, lprL, len: 188 aa. Equivalent to 5' end of Rv0593, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 188 aa overlap). Possible lprL (alternate gene name: mce2E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) introducing a stop codon,leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (188 aa versus 402 aa). Q7U1P3 No NC_002945.3 Mycobrowser_v2 CDS 694482 696032 . + 0 Mb0610 mce2F MCE-FAMILY PROTEIN MCE2F Mb0610, mce2F, len: 516 aa. Equivalent to Rv0594,len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 516 aa overlap). mce2F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Contains possible N-terminal signal or anchor sequence. Q7U1P2 No NC_002945.3 Mycobrowser_v2 CDS 696084 696476 . - 0 Mb0611c vapc4 possible toxin vapc4 Mb0611c, -, len: 130 aa. Equivalent to Rv0595c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112 aa) from Mycobacterium tuberculosis; and STBB_PSESM|Q52562 plasmid stability protein from Pseudomonas syringae (139 aa), FASTA scores: opt: 131, E(): 0.0035, (35.2% identity in 88 aa overlap). Q7U1P1 No virulence, detoxification, adaptation Rv0595c NC_002945.3 Mycobrowser_v2 CDS 696473 696730 . - 0 Mb0612c vapb4 possible antitoxin vapb4 Mb0612c, -, len: 85 aa. Equivalent to Rv0596c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, highly similar in part to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv0626, Rv3181c,Rv3385c, Rv3407, etc. Q7U1P0 No virulence, detoxification, adaptation Rv0596c NC_002945.3 Mycobrowser_v2 CDS 703261 704004 . + 0 Mb0622 possible transposase (fragment) Mb0622, -, len: 247 aa. Equivalent to Rv0606, len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Possible truncated transposase for IS_1536 element, highly similar to N-terminus of other transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (460 aa),FASTA scores: opt: 1368, E(): 0, (83.5% identity in 237 aa overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to N-terminus of MTV002_57|Rv2792 RESOLVASE from M. tuberculosis (193 aa), FASTA score: (87.4% identity in 238 aa overlap). Q7U1N0 No insertion seqs and phages Rv0606 NC_002945.3 Mycobrowser_v2 CDS 730572 731402 . - 0 Mb0650c POSSIBLE EXPORTED PROTEIN Mb0650c, -, len: 276 aa. Equivalent to Rv0633c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 279 aa overlap). Possible exported protein; has hydrophobic stretch at aa 23-41. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (cgggtgcgc-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (276 aa versus 279 aa). Q7U1K7 No cell wall and cell processes Rv0633c NC_002945.3 Mycobrowser_v2 CDS 696913 698148 . - 0 Mb0613c CONSERVED HYPOTHETICAL PROTEIN Mb0613c, -, len: 411 aa. Equivalent to Rv0597c,len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Conserved hypothetical protein, highly similar to Rv3179 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (429 aa). Also similar to AAF76191.1|AF271296_1|AF271296 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa); Rv2008c|YW09_MYCTU|Q10849 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (441 aa), FASTA scores: opt: 270, E(): 3.6e-11, (30.5% identity in 416 aa overlap) (N-terminus longer). Also similar to other hypothetical proteins e.g. NP_085874.1|NC_002679 hypothetical protein from Mesorhizobium loti (435 aa) (N-terminus longer). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1N9 No conserved hypotheticals Rv0597c NC_002945.3 Mycobrowser_v2 CDS 698399 698812 . - 0 Mb0614c vapc27 possible toxin vapc27. contains pin domain. Mb0614c, -, len: 137 aa. Equivalent to Rv0598c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein; similar to Rv2596|Y0B5_MYCTU|Q50625 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (134 aa), FASTA scores: opt: 254, E(): 8.2e-12, (41.5% identity in 130 aa overlap). Q7U1N8 No virulence, detoxification, adaptation Rv0598c NC_002945.3 Mycobrowser_v2 CDS 698809 699045 . - 0 Mb0615c vapb27 possible antitoxin vapb27 Mb0615c, -, len: 78 aa. Equivalent to Rv0599c, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, similar to Rv2595|Y0B6_MYCTU|Q50626 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (81 aa), FASTA scores: opt: 160, E(): 6.2e-07, (35.8% identity in 81 aa overlap). N-terminus shows stong similarity with N-terminus of NP_104908.1|NC_002678 hypothetical protein from Mesorhizobium loti (89 aa). Q7U1N7 No virulence, detoxification, adaptation Rv0599c NC_002945.3 Mycobrowser_v2 CDS 699149 699655 . - 0 Mb0616c two component sensor kinase [second part] Mb0616c, -, len: 168 aa. Equivalent to Rv0600c,len: 168 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 168 aa overlap). Probable two-component sensor kinase (second part) (EC 2.7.3.-), similar to part (C-termini) of many others e.g. Q04943|AFQ2_STRCO sensor protein afsq2 from Streptomyces coelicolor (535 aa), FASTA scores: opt: 347,E(): 1.9e-12, (33.0% identity in 206 aa overlap); etc. Note that sequence was checked and no errors were detected, which would allow this and the upstream ORF to be joined. Q7U1N6 No regulatory proteins Rv0600c NC_002945.3 Mycobrowser_v2 CDS 699769 700239 . - 0 Mb0617c two component sensor kinase [first part] Mb0617c, -, len: 156 aa. Equivalent to Rv0601c,len: 156 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 156 aa overlap). Probable two-component sensor kinase (first part) (EC 2.7.3.-), similar to part (N-termini) of others e.g. Q0375|CUTS_STRLI cuts protein from streptomyces lividans (414 aa), FASTA scores: opt: 230, E(): 3.1e-08,(39.1% identity in 115 aa overlap). Note that the sequence was checked and no errors were detected that would allow this and the downstream ORF to be joined. Q7U1N5 No regulatory proteins Rv0601c NC_002945.3 Mycobrowser_v2 CDS 700283 701044 . - 0 Mb0618c tcrA two component dna binding transcriptional regulatory protein tcra Mb0618c, tcrA, len: 253 aa. Equivalent to Rv0602c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 253 aa overlap). Probable tcrA,two-component DNA-binding response regulator, highly similar to others e.g. NP_107959.1|NC_002678 two-component response regulator from Mesorhizobium loti (239 aa); etc. Also similar to many other Mycobacterium tuberculosis two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c RESPONSE REGULATOR HOMOLOG TRCR (TCRV) (257 aa), FASTA score: (47.4 identity in 232 aa overlap); etc. Q7U1N4 No NC_002945.3 Mycobrowser_v2 CDS 701101 701412 . + 0 Mb0619 POSSIBLE EXPORTED PROTEIN Mb0619, -, len: 103 aa. Equivalent to Rv0603, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(98.1% identity in 103 aa overlap). Possible exported protein with hydrophobic stretch at aa 7-29. Q7U1N3 No cell wall and cell processes Rv0603 NC_002945.3 Mycobrowser_v2 CDS 701484 702434 . + 0 Mb0620 lpqO PROBABLE CONSERVED LIPOPROTEIN LPQO Mb0620, lpqO, len: 316 aa. Equivalent to Rv0604,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 316 aa overlap). Probable lpqO,conserved lipoprotein, highly similar to Rv2999|lppY PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (321 aa), FASTA scores: opt: 1153, E(): 0, (53.2% identity in 312 aa overlap). Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U1N2 No cell wall and cell processes Rv0604 NC_002945.3 Mycobrowser_v2 CDS 702651 703259 . + 0 Mb0621 POSSIBLE RESOLVASE Mb0621, -, len: 202 aa. Equivalent to Rv0605, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Possible resolvase for IS_Y349 element, similar to several Mycobacterial hypothetical proteins and weakly similar to Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa overlap). Contains PS00397 Site-specific recombinases active site and probable helix-turn helix motif from aa 9-30 (Score 1815, +5.37 SD). Q7U1N1 No insertion seqs and phages Rv0605 NC_002945.3 Mycobrowser_v2 CDS 707569 708174 . + 0 Mb0629 CONSERVED HYPOTHETICAL PROTEIN Mb0629, -, len: 201 aa. Equivalent to Rv0612, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Conserved hypothetical protein, highly similar, but in part, to downstream ORF Rv0609A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa); and showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis. Note that first start has been taken although this overlaps slightly with the upstream ORF. Q7U1M4 No conserved hypotheticals Rv0612 NC_002945.3 Mycobrowser_v2 CDS 4152372 4152563 . - 0 Mb3798c PROBABLE REMNANT OF A TRANSPOSASE Mb3798c, -, len: 63 aa. Equivalent to Rv3770B, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 379, E(): 1.6e-21, (93.55% identity in 62 aa overlap). Continues as Rv3770A. Q7TVQ2 No insertion seqs and phages Rv3770B NC_002945.3 Mycobrowser_v2 CDS 708193 710760 . - 0 Mb0630c unknown protein Mb0630c, -, len: 855 aa. Equivalent to Rv0613c,len: 855 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 855 aa overlap). Hypothetical unknown protein. Contains a very short region with strong similarity to several preprotein translocases e.g. P47847|SECA_LISMO preprotein translocase seca subunit (836 aa), FASTA scores: opt: 138, E(): 0.18, (38.6% identity in 70 aa overlap, and 72.7% identity in 22 aa overlap). Q7U1M3 No conserved hypotheticals Rv0613c NC_002945.3 Mycobrowser_v2 CDS 710601 711593 . + 0 Mb0631 CONSERVED HYPOTHETICAL PROTEIN Mb0631, -, len: 330 aa. Equivalent to Rv0614, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Conserved hypothetical protein, similar in part to Mycobacterium tuberculosis hypothetical proteins e.g. YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c CONSERVED HYPOTHETICAL PROTEIN (323 aa), FASTA scores: opt: 200,E(): 0.00016, (28.3% identity in 269 aa overlap); MTCY9F9_15 FASTA score: (40.3% identity in 144 aa overlap), Rv1949c, Rv2542, etc. Several start sites are possible; first start has been chosen. Note that this ORF overlaps with the upstream ORF. Q7U1M2 No conserved hypotheticals Rv0614 NC_002945.3 Mycobrowser_v2 CDS 711590 711832 . + 0 Mb0632 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb0632, -, len: 80 aa. Equivalent to Rv0615, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Probable integral membrane protein. Q7U1M1 No cell wall and cell processes Rv0615 NC_002945.3 Mycobrowser_v2 CDS 711829 712095 . - 0 Mb0633c HYPOTHETICAL PROTEIN Mb0633c, -, len: 88 aa. Equivalent to Rv0616c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein. Q7U1M0 No conserved hypotheticals Rv0616c NC_002945.3 Mycobrowser_v2 CDS 712027 712254 . + 0 Mb0633A vapB29 Possible antitoxin VapB29 Mb0633A, len: 75 aa. Equivalent to Rv0616A len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB29,antitoxin,part of toxin-antitoxin (TA) operon with Rv0617,see Arcus et al. 2005. Similar to many others in M. tuberculosis e.g. Rv2530A (74 aa) 35.9% identity in 78 aa overlap X2BFL8 No virulence, detoxification, adaptation Rv0616A NC_002945.3 Mycobrowser_v2 CDS 712251 712652 . + 0 Mb0634 vapc29 possible toxin vapc29. contains pin domain. Mb0634, -, len: 133 aa. Equivalent to Rv0617, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2494, Rv3320c,Rv0749, Rv0277c, Rv2530c, etc. Q7U1L9 No virulence, detoxification, adaptation Rv0617 NC_002945.3 Mycobrowser_v2 CDS 712781 713965 . + 0 Mb0635 galT probable galactose-1-phosphate uridylyltransferase galtb [second part] Mb0635, galT, len: 394 aa. Equivalent to Rv0618 and Rv0619, len: 231 aa (probable partial CDS) and 181 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 219 aa overlap and 99.4% identity in 174 aa overlap). Rv0618: Probable galT', first part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), highly similar to N-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa),FASTA scores: opt: 296, E(): 1.4e-11, (50.8% identity in 177 aa overlap); etc. Also highly similar to N-terminal half of some UDP glucose--hexose-1-phosphate uridylyltransferases (EC 2.7.7.12). N-terminal 28 aa similar to MTCY20H11.08|Rv0627|MTCY20H11.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), FASTA score: (71.4% identity in 28 aa overlap). BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE >FAMILY 1. Rv0619: Probable 'galT, second part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10),highly similar to C-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa),FASTA scores: opt: 416, E(): 5.2e-22, (43.0% identity in 186 aa overlap), etc. BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FAMILY 1. Cosmid sequence is correct but there may be a frameshift mutation in this region which would allow the two ORFS to be joined. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts,galT' and 'galT. In Mycobacterium bovis, an in-frame insertion of a single base (*-a) leads to a single product. Q7U1L8 No intermediary metabolism and respiration Rv0618 NC_002945.3 Mycobrowser_v2 CDS 757104 757541 . - 0 Mb0680c vapc7 possible toxin vapc7 Mb0680c, -, len: 145 aa. Equivalent to Rv0661c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2863|MTV003.09|MTV003_7 (126 aa), FASTA scores: E(): 0.00087, (30.4% identity in 125 aa overlap),Rv0749|MTV041.23 (163 aa); Rv0277c, Rv2530c, etc. Q7U1I6 No virulence, detoxification, adaptation Rv0661c NC_002945.3 Mycobrowser_v2 CDS 713962 715053 . + 0 Mb0636 galK PROBABLE GALACTOKINASE GALK (GALACTOSE KINASE) Mb0636, galK, len: 363 aa. Equivalent to Rv0620,len: 363 aa, from Mycobacterium tuberculosis strain H37RV,(99.7% identity in 362 aa overlap). Probable galK,galactokinase (EC 2.7.1.6), similar to others e.g. P13227|GAL1_STRLI GALACTOKINASE from Streptomyces lividans (397 aa); P06976|GAL1_ECOLI galactokinase from Escherichia coli (381 aa), FASTA scores: opt: 669, E(): 0, (35.9% identity in 365 aa overlap); etc. Contains PS00106 Galactokinase signature and PS00560 Serine carboxypeptidases, histidine active site. BELONGS TO THE GHMP KINASE FAMILY. GALK SUBFAMILY. X2BFN2,Q7U1L7 No intermediary metabolism and respiration Rv0620 NC_002945.3 Mycobrowser_v2 CDS 715448 716605 . + 0 Mb0637 POSSIBLE MEMBRANE PROTEIN Mb0637, -, len: 385 aa. Equivalent to Rv0621, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 354 aa overlap). Possible membrane protein; contains potential membrane spanning regions. Also contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa). Q7U1L6 No cell wall and cell processes Rv0621 NC_002945.3 Mycobrowser_v2 CDS 716616 717563 . + 0 Mb0638 POSSIBLE MEMBRANE PROTEIN Mb0638, -, len: 315 aa. Equivalent to Rv0622, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 315 aa overlap). Possible membrane protein; contains potential membrane spanning region. Shows weak similarity with Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, etc. Q7U1L5 No cell wall and cell processes Rv0622 NC_002945.3 Mycobrowser_v2 CDS 717656 717910 . + 0 Mb0639 vapb30 possible antitoxin vapb30 Mb0639, -, len: 84 aa. Equivalent to Rv0623, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Conserved hypothetical protein, highly similar to NP_384911.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (84 aa). Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 CONSERVED HYPOTHETICAL PROTEIN (70 aa), FASTA score: (73.5% identity in 68 aa overlap); MTCY4C12_25|Rv0608|MTCY19H5.14c CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA score: (73.5 identity in 68 aa overlap); etc. Q7U1L4 No virulence, detoxification, adaptation Rv0623 NC_002945.3 Mycobrowser_v2 CDS 717910 718305 . + 0 Mb0640 vapc30 possible toxin vapc30. contains pin domain. Mb0640, -, len: 131 aa. Equivalent to Rv0624, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, highly similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1741, Rv0609,Rv2759c,Rv0565c, Rv3854c, Rv3083, etc. X2BFK5,P67241 No virulence, detoxification, adaptation Rv0624 NC_002945.3 Mycobrowser_v2 CDS 718399 719139 . - 0 Mb0641c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0641c, -, len: 246 aa. Equivalent to Rv0625c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Probable conserved transmembrane protein, showing similarity with others e.g. CAB61866.1|AL133252 putative integral membrane protein from Streptomyces coelicolor (249 aa). Also similar to Rv1491c|MTCY277_13 from Mycobacterium tuberculosis. Contains potential membrane spanning regions. X2BFN9,P67116 No cell wall and cell processes Rv0625c NC_002945.3 Mycobrowser_v2 CDS 719271 719531 . + 0 Mb0642 vapb5 possible antitoxin vapb5 Mb0642, -, len: 86 aa. Equivalent to Rv0626, len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv0596c, Rv3385c,Rv3407,Rv3181c, etc. Q7U1L3 No virulence, detoxification, adaptation Rv0626 NC_002945.3 Mycobrowser_v2 CDS 719528 719935 . + 0 Mb0643 vapc5 possible toxin vapc5 Mb0643, -, len: 135 aa. Equivalent to Rv0627, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv0595c and Rv0665. Q7U1L2 No virulence, detoxification, adaptation Rv0627 NC_002945.3 Mycobrowser_v2 CDS 720007 721158 . - 0 Mb0644c CONSERVED HYPOTHETICAL PROTEIN Mb0644c, -, len: 383 aa. Equivalent to Rv0628c,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Conserved hypothetical protein, highly similar to Rv0874c|YZ02_MYCTU|Q10536 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 2082, E(): 0, (81.5% identity in 383 aa overlap). Also some similarity to P72543|SPU62616_1 HYPOTHETICAL PROTEIN from Synechococcus, FASTA scores: E(): 2.8e-28,(36.6 identity in 265 aa overlap). X2BFF5,P64730 No conserved hypotheticals Rv0628c NC_002945.3 Mycobrowser_v2 CDS 757538 757906 . - 0 Mb0681c vapb7 possible antitoxin vapb7 Mb0681c, -, len: 122 aa. Equivalent to Rv0662c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Conserved hypothetical protein, showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2871, Rv1241, Rv2550c, etc. Q7U1I5 No virulence, detoxification, adaptation Rv0662c NC_002945.3 Mycobrowser_v2 CDS 721251 722978 . - 0 Mb0645c recD PROBABLE EXONUCLEASE V (ALPHA CHAIN) RECD (EXODEOXYRIBONUCLEASE V ALPHA CHAIN) (EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0645c, recD, len: 575 aa. Equivalent to Rv0629c,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 575 aa overlap). Probable recD,exonuclease V, alpha chain (exodeoxyribonuclease V, alpha chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_3|AAD46809.1|recD Escherichia coli RecD protein homolog from Mycobacterium smegmatis (554 aa); P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease v 67kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V ALPHA CHAIN) from Escherichia coli strain K12 (608 aa), FASTA scores: opt: 512, E(): 1.9e-24, (36.9% identity in 582 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). CONSIST OF THREE SUBUNITS; RECB|Rv0630c,RECC|Rv0631c AND RECD. Q7U1L1 No NC_002945.3 Mycobrowser_v2 CDS 722975 723679 . - 0 Mb0646c recBb PROBABLE EXONUCLEASE V (BETA CHAIN) RECBB [SECOND PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0646c, recBb, len: 234 aa. Equivalent to 3' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 234 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V, beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb. No NC_002945.3 Mycobrowser_v2 CDS 723565 726258 . - 0 Mb0647c recBa PROBABLE EXONUCLEASE V (BETA CHAIN) RECBA [FIRST PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0647c, recBa, len: 897 aa. Equivalent to 5' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 868 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V,beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb. Q7U1L0 No NC_002945.3 Mycobrowser_v2 CDS 726258 729551 . - 0 Mb0648c recC PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC (EXODEOXYRIBONUCLEASE V GAMMA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0648c, recC, len: 1097 aa. Equivalent to Rv0631c,len: 1097 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1097 aa overlap). Probable recC,exonuclease V, gamma chain (exodeoxyribonuclease V, gamma chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein homolog from Mycobacterium smegmatis (1085 aa); P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease v 125 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V GAMMA CHAIN) from Escherichia coli strain K12 (1122 aa), FASTA scores: opt: 954, E(): 0, (29.2% identity in 1109 aa overlap); etc. CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC AND RECD|Rv0629c. Q7U1K9 No NC_002945.3 Mycobrowser_v2 CDS 805511 806104 . + 0 Mb0726 rplV 50s ribosomal protein l22 rplv Mb0726, rplV, len: 197 aa. Equivalent to Rv0706,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Probable rplV, 50S ribosomal protein L22, equivalent to O06115|RL22_MYCSM 50S RIBOSOMAL PROTEIN L22 from Mycobacterium smegmatis (153 aa); MBS10OPER_7 50S RIBOSOMAL PROTEIN L22 from Mycobacterium bovis BCG; and MLCB2492_7 50S ribosomal protein L22 from Mycobacterium leprae (175 aa). Also highly similar to others e.g. CAB82075.1|AL161803 50S ribosomal protein L22 from Streptomyces coelicolor (125 aa); P42060|RL22_BACSU 50s ribosomal protein L22 from Bacillus subtilis (113 aa), FASTA scores: opt: 368, E(): 2.4e-13, (52.8% identity in 108 aa overlap); etc. Contains PS00464 Ribosomal protein L22 signature, and contains repetitive sequence at C-terminus. BELONGS TO THE L22P FAMILY OF RIBOSOMAL PROTEINS. X2BFW8,P61180 No information pathways Rv0706 NC_002945.3 Mycobrowser_v2 CDS 729828 730523 . - 0 Mb0649c echA3 PROBABLE ENOYL-COA HYDRATASE ECHA3 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0649c, echA3, len: 231 aa. Equivalent to Rv0632c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Probable echA3,enoyl-CoA hydratase (EC 4.2.1.17), almost identical to the MTU88877_1 enoyl-coA hydratase of Mycobacterium tuberculosis field isolate NTI64719, FASTA score: (92.4% identity in 184 aa overlap). Also similar to others e.g. P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores: opt: 206, E(): 6.3e-07, (31.5% identity in 232 aa overlap); etc. Q7U1K8 No NC_002945.3 Mycobrowser_v2 CDS 731556 732269 . - 0 Mb0651c POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II) Mb0651c, -, len: 237 aa. Equivalent to Rv0634c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Possible glyoxalase II (EC 3.1.2.6), equivalent to NP_302290.1|NC_002677 putative glyoxylase II from Mycobacterium leprae (238 aa); and similar to U00011_3|Y0BK_MYCLE|Q49649 hypothetical 23.9 kd protein from Mycobacterium leprae (218 aa), FASTA scores: opt: 281, E(): 3.9e-12, (31.8% identity in 201 aa overlap). Also similar to other glyoxalases and metallo-beta-lactamase family proteins e.g. NP_386770.1|NC_003047 PUTATIVE HYDROXYACYLGLUTATHIONE HYDROLASE from Sinorhizobium meliloti (256 aa); etc. Also similar to other putative glyoxylases from Mycobacterium tuberculosis e.g. Rv1637c. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS. Q7U1K6 No virulence, detoxification, adaptation Rv0634c NC_002945.3 Mycobrowser_v2 tRNA 732839 732912 . + 0 metT metT tRNA-Met metT, len: 74 nt. Equivalent to metT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Met, anticodon cat. No NC_002945.3 Mycobrowser_v2 CDS 732948 733115 . + 0 Mb0653 rpmG2 50s ribosomal protein l33 rpmg2 Mb0653, rpmG2, len: 55 aa. Equivalent to Rv0634B,len: 55 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 55 aa overlap). Probable rpmG2, 50S ribosomal protein L33. Note that Mycobacterium tuberculosis has a second rpmG gene: P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1 PUTATIVE 50S RIBOSOMAL PROTEIN L33 (55 aa), FASTA scores: opt: 391,E(): 2.9e-25, (100.0% identity in 55 aa overlap). BELONGS TO THE L33P FAMILY OF RIBOSOMAL PROTEINS. X2BFN0,P0A5W3 No NC_002945.3 Mycobrowser_v2 CDS 733166 733642 . + 0 Mb0654 hada (3r)-hydroxyacyl-acp dehydratase subunit hada Mb0654, -, len: 158 aa. Equivalent to Rv0635, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, equivalent to NP_302287.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (159 aa); and highly similar to YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa), FASTA scores: opt: 387, E(): 5.9e-21, (43.4% identity in 145 aa overlap). Also similar CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). And highly similar to two hypothetical proteins from Mycobacterium tuberculosis: Rv0504c|YV31_MYCTU|Q11168 (166 aa), FASTA scores: opt: 405, E(): 3.2e-22, (45.0% identity in 140 aa overlap); and Rv0637|MTY20H10_19 (2 ORFs downstream) (166 aa), FASTA score: (48.7% identity in 150 aa overlap). X2BFG4 No intermediary metabolism and respiration Rv0635 NC_002945.3 Mycobrowser_v2 CDS 733629 734057 . + 0 Mb0655 hadb (3r)-hydroxyacyl-acp dehydratase subunit hadb Mb0655, -, len: 142 aa. Equivalent to Rv0636, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Conserved hypothetical protein, equivalent to NP_302286.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (142 aa). Also highly similar to CAB77411.1|AL160431|SCD82.08 hypothetical protein from Streptomyces coelicolor (142 aa); and similar to others e.g. U28943|CELE04F6_3 from Caenorhabditis elegans (cosmid E04) (298 aa), FASTA scores: opt: 167, E(): 0.00064, (31.6 identity in 117 aa overlap). Q7U1K3 No intermediary metabolism and respiration Rv0636 NC_002945.3 Mycobrowser_v2 CDS 734061 734561 . + 0 Mb0656 hadc (3r)-hydroxyacyl-acp dehydratase subunit hadc Mb0656, -, len: 166 aa. Equivalent to Rv0637, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, equivalent to NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa),FASTA scores: opt: 352, E(): 4e-19, (39.2% identity in 148 aa overlap); and highly similar to others from Mycobacterium leprae e.g. NP_302287.1|NC_002677 conserved hypothetical protein (159 aa). Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa); Rv0635|NP_215149.1|NC_000962|MTY20H10_17 conserved hypothetical protein (two ORFs upstream) from Mycobacterium tuberculosis (158 aa), FASTA score: (49.3% identity in 150 aa overlap); and Rv0504c|NP_215018.1|NC_000962|YV31_MYCTU|Q11168 hypothetical protein from Mycobacterium tuberculosis (166 aa), FASTA scores: opt: 380, E(): 3.8e-21, (43.1% identity in 137 aa overlap). X2BFQ7 No intermediary metabolism and respiration Rv0637 NC_002945.3 Mycobrowser_v2 tRNA 734760 734832 . + 0 trpT trpT tRNA-Trp trpT, len: 73 nt. Equivalent to trpT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Trp, anticodon cca. No NC_002945.3 Mycobrowser_v2 CDS 734973 735458 . + 0 Mb0657 secE1 PROBABLE PREPROTEIN TRANSLOCASE SECE1 Mb0657, secE1, len: 161 aa. Equivalent to Rv0638,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Probable secE1,preprotein translocase (tail-anchored membrane protein),highly similar at C-terminal half to others e.g. P36690|SECE_STRGR PREPROTEIN TRANSLOCASE SECE SUBUNIT from Streptomyces griseus (86 aa), FASTA scores: opt: 220, E(): 4.6e-06, (35.4% identity in 96 aa overlap); P16920|SECE_ECOLI preprotein translocase sece subunit from Escherichia coli strains K12 and O157:H7 (127 aa), FASTA scores: opt: 122, E(): 0.34, (37.0% identity in 54 aa overlap); etc. Contains PS01067 Protein secE/sec61-gamma signature. BELONGS TO THE SECE/SEC61-GAMMA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE, SECF|Rv2586c,SECG|Rv1440 AND SECY|Rv0732. Note that previously known as secE. X2BFN4,P0A5Z1 No NC_002945.3 Mycobrowser_v2 CDS 735490 736206 . + 0 Mb0658 nusG PROBABLE TRANSCRIPTION ANTITERMINATION PROTEIN NUSG Mb0658, nusG, len: 238 aa. Equivalent to Rv0639,len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Probable nusG,transcription antitermination protein, equivalent to NP_302283.1|NC_002677 transcription antitermination protein nusG from Mycobacterium leprae (228 aa). Also highly similar to others e.g. P36260|NUSG_STRGR from Streptomyces griseus (294 aa), FASTA scores: opt: 845,E(): 0, (55.4% identity in 233 aa overlap); etc. Note that shorter at the N-terminus than other nusG. Contains PS01014 Transcription termination factor nusG signature. BELONGS TO THE NUSG FAMILY. X2BFN3,P65590 No information pathways Rv0639 NC_002945.3 Mycobrowser_v2 CDS 736258 736686 . + 0 Mb0659 rplK 50s ribosomal protein l11 rplk Mb0659, rplK, len: 142 aa. Equivalent to Rv0640,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable rplK, 50S ribosomal protein L11, equivalent to NP_302282.1|NC_002677 50S ribosomal protein L11 from Mycobacterium leprae (142 aa). Also highly similar to others e.g. P48954|RL11_STRCO|SCD82.19 50s ribosomal protein L11 from Streptomyces coelicolor (144 aa), FASTA scores: opt: 763,E(): 0, (84.6% identity in 143 aa overlap); etc. Contains PS00359 Ribosomal protein L11 signature. BELONGS TO THE L11P FAMILY OF RIBOSOMAL PROTEINS. X2BFH0,P66057 No information pathways Rv0640 NC_002945.3 Mycobrowser_v2 CDS 737534 738439 . - 0 Mb0661c mmaA4 METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0661c, mmaA4, len: 301 aa. Equivalent to Rv0642c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 301 aa overlap). mmaA4, methoxy mycolic acid synthase 4 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (298 aa); NP_302280.1|NC_002677 methyl mycolic acid synthase 4 from Mycobacterium leprae (298 aa); and highly similar to others from Mycobacteria e.g. downstream ORF P72027|mmaA3|Rv0643c|MTCY20H10.24c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 3 from Mycobacterium tuberculosis (293 aa). X2BFR1,Q7U1K1 No NC_002945.3 Mycobrowser_v2 CDS 738504 739385 . - 0 Mb0662c mmaA3 METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0662c, mmaA3, len: 293 aa. Equivalent to Rv0643c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 293 aa overlap). mmaA3, methoxy mycolic acid synthase 3 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (289 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). X2BFP0,Q7U1K0 No NC_002945.3 Mycobrowser_v2 CDS 739533 740396 . - 0 Mb0663c mmaA2 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 (METHYL MYCOLIC ACID SYNTHASE 2) (MMA2) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0663c, mmaA2, len: 287 aa. Equivalent to Rv0644c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). mmaA2, methoxy mycolic acid synthase 2 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (287 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). Note that alternative start is at position 739247. X2BFN6,Q7U1J9 No NC_002945.3 Mycobrowser_v2 CDS 740563 741423 . - 0 Mb0664c mmaA1 METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0664c, mmaA1, len: 286 aa. Equivalent to Rv0645c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). mmaA1, methoxy mycolic acid synthase 1 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to NP_302279.1|NC_002677 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). X2BFH5,P0A5Q1 No NC_002945.3 Mycobrowser_v2 CDS 741470 742375 . - 0 Mb0665c lipG PROBABLE LIPASE/ESTERASE LIPG Mb0665c, lipG, len: 301 aa. Equivalent to Rv0646c,len: 301 aa. from Mtycobacterium tuberculosis strain H37Rv, (100.0% identity in 301 aa overlap). Probable lipG,lipase/esterase (EC 3.1.-.-), equivalent to NP_302278.1|NC_002677 probable hydrolase from Mycobacterium leprae (304 aa). Also highly similar to various hydrolases, especially lipases e.g. AA61351.1|X88895 carboxyl esterase from Acinetobacter calcoaceticus (312 aa), FASTA scores: opt: 867, E(): 0,(50.2% identity in 279 aa overlap); etc. Also similar to transferases e.g. P77026 MACROLIDE 2'-PHOSPHOTRANSFERASE II from Escherichia coli (279 aa), FASTA scores: E(): 1.3e-14, (32.5% identity in 286 aa overlap). Similar to M. tuberculosis non-heme bromoperoxidases and epoxide hydrolases. Q7U1J8 No NC_002945.3 Mycobrowser_v2 CDS 742387 743853 . - 0 Mb0666c conserved protein Mb0666c, -, len: 488 aa. Equivalent to Rv0647c,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Conserved hypothetical protein, equivalent to NP_302277.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (448 aa). Also showing similarity to a variety of hypothetical ABC1-LIKE proteins or conserved hypothetical proteins e.g. D90908_28|P73627 ABC1-LIKE PROTEIN from Synechocystis (585 aa), FASTA scores: E(): 1.8e-31, (29.1% identity in 474 aa overlap); Q55884 HYPOTHETICAL6 5.0 KD PROTEIN (567 aa),FASTA scores: opt: 583, E(): 5.7e-30, (28.1% identity in 416 aa overlap); etc. Also similar to Rv3197 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. Q7U1J7 No conserved hypotheticals Rv0647c NC_002945.3 Mycobrowser_v2 CDS 744488 748135 . + 0 Mb0667 ALPHA-MANNOSIDASE Mb0667, -, len: 1215 aa. Equivalent to Rv0648, len: 1215 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 1215 aa overlap). Alpha-mannosidase (EC 3.2.1.-) (see citation below), showing some similarity to hypothetical proteins and various sugar hydrolases e.g. SYCSLRA_6|Q55528 HYPOTHETICAL 1 20.4 KD PROTEIN from Synechocystis (1042 aa), FASTA scores: opt: 260, E(): 3.6e-08, (23.4% identity in 602 aa overlap); etc. Contains PS00659 Glycosyl hydrolases family 5 signature. Q7U1J6 No intermediary metabolism and respiration Rv0648 NC_002945.3 Mycobrowser_v2 CDS 748132 748806 . + 0 Mb0668 fabD2 possible malonyl coa-acyl carrier protein transacylase fabd2 (mct) Mb0668, fabD2, len: 224 aa. Equivalent to Rv0649,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible fabD2,malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39), similar to MTFABD|FABD_MYCTU|Q10501|Rv2243 malonyl CoA-acyl carrier protein transacylase from Mycobacterium tuberculosis (302 aa), FASTA scores: opt: 133, E(): 0.074, (31.3% identity in 147 aa overlap). Q7U1J5 No NC_002945.3 Mycobrowser_v2 CDS 748806 749714 . + 0 Mb0669 POSSIBLE SUGAR KINASE Mb0669, -, len: 302 aa. Equivalent to Rv0650, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Possible sugar kinase, highly similar to others e.g. CAB95296.1|AL359779 putative sugar kinase from Streptomyces coelicolor (317 aa); NP_406512.1|NC_003143 putative sugar kinase from Yersinia pestis (290 aa); NP_229269.1|NC_000853 glucokinase from Thermotoga maritima (317 aa); etc.Contains PS01125 ROK family signature. BELONGS TO THE ROK (NAGC/XYLR) FAMILY. Q7U1J4 No intermediary metabolism and respiration Rv0650 NC_002945.3 Mycobrowser_v2 CDS 750045 750581 . + 0 Mb0670 rplJ 50s ribosomal protein l10 rplj Mb0670, rplJ, len: 178 aa. Equivalent to Rv0651,len: 178 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 178 aa overlap). Probable rplJ, 50S ribosomal protein L10, equivalent to NP_302276.1|NC_002677 50S ribosomal protein L10 from Mycobacterium leprae (177 aa). Also highly similar to others e.g. P36257|RL10_STRGR 50s ribosomal protein L10 from Streptomyces griseus (185 aa), FASTA scores: opt: 633, E(): 0, (59.0 % identity in 173 aa overlap); etc. BELONGS TO THE L10P FAMILY OF RIBOSOMAL PROTEINS. X2BFP4,P66045 No information pathways Rv0651 NC_002945.3 Mycobrowser_v2 CDS 750618 751010 . + 0 Mb0671 rplL 50s ribosomal protein l7/l12 rpll (sa1) Mb0671, rplL, len: 130 aa. Equivalent to Rv0652,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Probable rplL (alternate gene name: L7|L12), 50S ribosomal protein L7/L12, equivalent to NP_302275.1|NC_002677 50S ribosomal protein L7/L12 from Mycobacterium leprae (130 aa); and P37381|RL7_MYCBO 50s ribosomal protein L7/L12 from Mycobacterium bovis (130 aa). Also highly similar to others e.g. P02396|RL7_STRGR 50S RIBOSOMAL PROTEIN L7/L12 from Streptomyces griseus (127 aa); etc. BELONGS TO THE L12P FAMILY OF RIBOSOMAL PROTEINS. X2BFS4,P0A5V3 No information pathways Rv0652 NC_002945.3 Mycobrowser_v2 CDS 751003 751698 . - 0 Mb0672c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb0672c, -, len: 231 aa. Equivalent to Rv0653c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible transcriptional regulator, TetR family, similar in N-terminus to others e.g. CAC03642.1|AL391338 putative TetR-family transcriptional regulator from Streptomyces coelicolor (190 aa); Q51597 CAM REPRESSOR from Pseudomonas putida (186 aa), FASTA scores: opt: 150, E(): 0.00085,(27.8% identity in 97 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis hypothetical transcriptional regulators Rv0681 and Rv1816. Contains probable helix-turn helix motif from aa 27-48 (Score 1156,+3.12 SD). Q7U1J3 No regulatory proteins Rv0653c NC_002945.3 Mycobrowser_v2 CDS 751769 753274 . + 0 Mb0673 PROBABLE DIOXYGENASE Mb0673, -, len: 501 aa. Equivalent to Rv0654, len: 501 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 501 aa overlap). Probable dioxygenase (EC 1.-.-.-), highly similar to others eg AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase (involved in tetraene formation) from Streptomyces antibioticus (456 aa); CAB56138.1| AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); T51734 neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid dioxygenase) from Arabidopsis thaliana (538 aa); Q53353 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE from Pseudomonas paucimobilis (Sphingomonas paucimobilis), FASTA scores: opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa overlap); etc. Also some similarity with Rv0913c|MTCY21C12.07c POSSIBLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa), FASTA score: (29.5% identity in 522 aa overlap). Q7U1J2 No intermediary metabolism and respiration Rv0654 NC_002945.3 Mycobrowser_v2 CDS 753286 754365 . + 0 Mb0674 mkl POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL Mb0674, mkl, len: 359 aa. Equivalent to Rv0655,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Possible mkl,ribonucleotide-transport ATP-binding protein ABC transporter (see first citation below), equivalent to P30769|MKL_MYCLE|ML1892 POSSIBLE RIBONUCLEOTIDE TRANSPORT ATP-BINDING PROTEIN from Mycobacterium leprae (347 aa),FASTA scores: opt: 2021, E(): 0, (92.2% identity in 335 aa overlap). Also highly similar to many e.g. AB92896.1|AL356992 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (343 aa); NP_253146.1|NC_002516 probable ATP-binding component of ABC transporter from Pseudomonas aeruginosa (269 aa); P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding protein from Escherichia coli (269 aa), FASTA scores: opt: 644, E(): 3.4e-33, (38.5% identity in 244 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351 aa), FASTA score: (33.6% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BFI5,P63358 No cell wall and cell processes Rv0655 NC_002945.3 Mycobrowser_v2 CDS 755231 755386 . - 0 Mb0676c vapb6 possible antitoxin vapb6 Mb0676c, -, len: 51 aa. Equivalent to Rv0657c, len: 51 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 51 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa),FASTA scores: opt: 107, E(): 0.0038, (45.8% identity in 48 aa overlap), Rv2871, Rv1560, etc. Also some similarity with AL020958|SC4H8_7 from Streptomyces coelicolor (66 aa), FASTA score: (41.0% identity in 39 aa overlap). Q7U1J0 No virulence, detoxification, adaptation Rv0657c NC_002945.3 Mycobrowser_v2 CDS 755462 756178 . - 0 Mb0677c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0677c, -, len: 238 aa. Equivalent to Rv0658c,len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 238 aa overlap). Probable conserved integral membrane protein, similar to P33774|YPRB_ECOLI hypothetical 24.3 kd protein from Escherichia coli (217 aa), FASTA scores: opt: 174, E(): 5.3e-05, (25.6% identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis. Q7U1I9 No cell wall and cell processes Rv0658c NC_002945.3 Mycobrowser_v2 CDS 756454 756762 . - 0 Mb0678c mazf2 toxin mazf2 Mb0678c, -, len: 102 aa. Equivalent to Rv0659c,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, weakly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1942c, Rv1495, etc. Q7U1I8 No virulence, detoxification, adaptation Rv0659c NC_002945.3 Mycobrowser_v2 CDS 756749 756994 . - 0 Mb0679c maze2 possible antitoxin maze2 Mb0679c, -, len: 81 aa. Equivalent to Rv0660c, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing some similarity to AF016485_130 from Halobacterium sp (100 aa), FASTA scores: (32.4% identity in 74 aa overlap). Q7U1I7 No virulence, detoxification, adaptation Rv0660c NC_002945.3 Mycobrowser_v2 CDS 757906 760269 . + 0 Mb0682 atsD POSSIBLE ARYLSULFATASE ATSD (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE) Mb0682, atsD, len: 787 aa. Equivalent to Rv0663,len: 787 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 787 aa overlap). Possible atsD,arylsulfatase (EC 3.1.6.1), similar to others e.g. P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% identity in 544 aa overlap); etc. Also similar to P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from Mycobacterium tuberculosis (787 aa), FASTA score: (38.9% identity in 769 aa overlap); and other arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa),Rv0711, etc. Contains PS00523 Sulfatases signature 1. BELONGS TO THE SULFATASE FAMILY. Q7U1I4 No intermediary metabolism and respiration Rv0663 NC_002945.3 Mycobrowser_v2 CDS 761576 765094 . + 0 Mb0686 rpoB DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) Mb0686, rpoB, len: 1172 aa. Equivalent to Rv0667,len: 1172 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1172 aa overlap). rpoB,DNA-directed RNA polymerase, beta chain (EC 2.7.7.6) (see first and third citations below), equivalent to P30760|RPOB_MYCLE|ML1891 DNA-directed RNA polymerase beta chain from Mycobacterium leprae (1178 aa). Also highly similar to others e.g. AAF60349.1|AF242549_1|AF242549 DNA-dependent RNA polymerase beta subunit from Amycolatopsis mediterranei (1167 aa); CAB77428.1|AL160431 DNA-directed RNA polymerase beta chain from Streptomyces coelicolor (1161 aa); etc. Start site chosen on basis of RBS but alternative start exists at position 14359. BELONGS TO THE RNA POLYMERASE BETA CHAIN FAMILY. X2BFU0,P0A681 No NC_002945.3 Mycobrowser_v2 CDS 765139 769089 . + 0 Mb0687 rpoC DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). Mb0687, rpoC, len: 1316 aa. Equivalent to Rv0668,len: 1316 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1316 aa overlap). rpoC,DNA-directed RNA polymerase, beta' chain (EC 2.7.7.6) (see first citation below), equivalent to P30761|RPOC_MYCLE|ML1890|S31146 DNA-directed RNA polymerase (EC 2.7.7.6) beta' chain from Mycobacterium leprae (1316 aa), FASTA scores: opt: 8295, E(): 0, (95.6% identity in 1316 aa overlap). Also highly similar to others e.g. CAB77429.1|AL160431 DNA-directed RNA polymerase beta' chain (fragment) from Streptomyces coelicolor (1059 aa); P37871|RPOC_BACSU from Bacillus subtilis (1199 aa), FASTA scores: opt: 2367, E(): 0, (52.9 identity in 1317 aa overlap); etc. BELONGS TO THE RNA POLYMERASE BETA' CHAIN FAMILY. X2BFS1,P0A675 No NC_002945.3 Mycobrowser_v2 CDS 769453 771366 . - 0 Mb0688c POSSIBLE HYDROLASE Mb0688c, -, len: 637 aa. Equivalent to Rv0669c,len: 637 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 637 aa overlap). Possible hydrolase (EC 3.-.-.-), highly similar to various hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 alkaline ceramidase from Pseudomonas aeruginosa (670 aa,) FASTA scores: opt: 1490,E(): 0, (41.2% identity in 651 aa overlap); NP_063946.1|NM_019893 mitochondrial ceramidase from Homo sapiens (761 aa); P_446098.1|NM_053646 N-acylsphingosine amidohydrolase 2 from Rattus norvegicus (761 aa); BAB09641.1|AB016885 neutral ceramidase from Arabidopsis thaliana (705 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1I0 No intermediary metabolism and respiration Rv0669c NC_002945.3 Mycobrowser_v2 CDS 771561 772319 . + 0 Mb0689 end PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Mb0689, end, len: 252 aa. Equivalent to Rv0670,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable end (alternate gene name: nfo), endonuclease IV (apurinase) (EC 3.1.21.2), equivalent to END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV (apurinase) from Mycobacterium leprae (252 aa), FASTA scores: opt: 1463, E(): 0, (85.6% identity in 250 aa overlap). Also similar to others e.g. Q9S2N2|END4_STRCO|NFO|SC6E10.05 PROBABLE ENDONUCLEASE IV from Streptomyces coelicolor (294 aa); etc. Contains PS00729 AP endonucleases family 2 signatures 1 and 2 (PS00729, and PS00730). BELONGS TO THE AP ENDONUCLEASES FAMILY 2. COFACTOR: BINDS 3 ZINC IONS. X2BFK7,P63536 No information pathways Rv0670 NC_002945.3 Mycobrowser_v2 CDS 772351 773193 . + 0 Mb0690 lpqP POSSIBLE CONSERVED LIPOPROTEIN LPQP Mb0690, lpqP, len: 280 aa. Equivalent to Rv0671,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Possible lpqP,conserved lipoprotein, similar to U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302 aa), FASTA scores: opt: 449, E(): 2.4e-22, (37.6% identity in 242 aa overlap). Also highly similar to lpqC|Rv3298c|MTCY71.38c PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (304 aa). Also similar to a large variety of proteins including various esterases and poly(3-hydroxyalkanoate) depolymerases, e.g. NP_249234.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (322 aa); C-terminus of AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase EstA from Piromyces equi (536 aa); part of P52090|PHA1_PSELE POLY(3-HYDROXYALKANOATE) DEPOLYMERASE C PRECURSOR from Pseudomonas lemoignei (414 aa); CAC10310.1|AL442629 putative secreted protein from Streptomyces coelicolor (348 aa); etc. Has a 17 aa signal sequence and contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site. Q7U1H9 No cell wall and cell processes Rv0671 NC_002945.3 Mycobrowser_v2 CDS 773253 774881 . + 0 Mb0691 fadE8 PROBABLE ACYL-COA DEHYDROGENASE FADE8 Mb0691, fadE8, len: 542 aa. Equivalent to Rv0672,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 542 aa overlap). Probable fadE8,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAC33951.1|AL589708 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (557 aa); P33224|AIDB_ECOLI|B4187 aidb protein (ACYL-COA DEHYDROGENASES FAMILY) from Escherichia coli strain K12 (546 aa), FASTA scores: opt: 1369, E(): 0, (44.1% identity in 524 aa overlap); etc. Also similar to several other M. tuberculosis proteins e.g. Rv0154cRv0154c|MTCI5.28c FASTA score: (26.3% identity in 342 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073). BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7U1H8 No NC_002945.3 Mycobrowser_v2 CDS 774892 775830 . + 0 Mb0692 echA4 POSSIBLE ENOYL-COA HYDRATASE ECHA4 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0692, echA4, len: 312 aa. Equivalent to Rv0673,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 312 aa overlap). Possible echA4,enoyl-CoA hydratase (EC 4.2.1.17), showing similarity with others e.g. NP_419216.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (256 aa); Q52995|ECHH_RHIME PROBABLE ENOYL-COA HYDRATASE from Sinorhizobium meliloti (257 aa), FASTA scores: opt: 210, E(): 1.2e-06, (27.9% identity in 280 aa overlap); etc. Also similar to other enoyl-CoA hydratases from Mycobacterium tuberculosis e.g. P95279|MTCY09F9.29|ECHA13|Rv1935c|MTCY09F9.29 ENOYL-COA HYDRATASE (318 aa), FASTA score: (27.1% identity in 280 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1H7 No NC_002945.3 Mycobrowser_v2 CDS 775833 776555 . + 0 Mb0693 CONSERVED HYPOTHETICAL PROTEIN Mb0693, -, len: 240 aa. Equivalent to Rv0674, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Conserved hypothetical protein, highly similar to AC13063.1|AL445503 conserved hypothetical protein from Streptomyces coelicolor (268 aa); and similar to NP_438100.1|NC_003078 putative regulator of phenylacetic acid degradation ArsR family protein from Sinorhizobium meliloti (306 aa) and other proteins e.g. AB011837|AB011837_13 hypothetical protein from Bacillus halodurans (298 aa), FASTA scores: opt: 148, E(): 0.0081, (25.1% identity in 235 aa overlap); etc. Q7U1H6 No conserved hypotheticals Rv0674 NC_002945.3 Mycobrowser_v2 CDS 776552 777343 . + 0 Mb0694 echA5 PROBABLE ENOYL-COA HYDRATASE ECHA5 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0694, echA5, len: 263 aa. Equivalent to Rv0675,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 263 aa overlap). Probable echA5,enoyl-CoA hydratase (EC 4.2.1.17), similar to several e.g. NP_252116.1|NC_002516 probable enoyl CoA-hydratase/isomerase from Pseudomonas aeruginosa (256 aa); Q20376 PROTEIN SIMILAR TO ENOYL-COA HYDRATASE from Caenorhabditis elegans (258 aa), FASTA scores: opt: 697,E(): 0, (47.3% identity in 245 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Z92669|MTCY8D5_17 (262 aa), FASTA scores: opt: 493, E(): 3.6e-25, (39.1% identity in 243 aa overlap); etc. Q7U1H5 No NC_002945.3 Mycobrowser_v2 CDS 883922 884608 . + 0 Mb0810 unknown protein Mb0810, -, len: 228 aa. Equivalent to hypothetical protein MT0811, len: 242 aa, from Mycobacterium tuberculosis strain CDC1551 (94% identity with 228 aa overlap). Hypothetical unknown protein, equivalent to AAK45053.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 77 aa. Mb0810 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BG72 No NC_002945.3 Mycobrowser_v2 CDS 783703 784173 . + 0 Mb0702 rpsG 30s ribosomal protein s7 rpsg Mb0702, rpsG, len: 156 aa. Equivalent to Rv0683,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Probable rpsG, 30S ribosomal protein S7 (see citation below), equivalent to others from Mycobacteria e.g. P41193|RS7_MYCSM 30S RIBOSOMAL PROTEIN S7 from Mycobacterium smegmatis (156 aa), FASTA scores: opt: 986, E(): 0, (96.2% identity in 156 aa overlap); Q53539|RS7_MYCBO 30S RIBOSOMAL PROTEIN S7 from Mycobacterium bovis (156 aa); etc. Also highly similar to others e.g. Q9L0K4|RS7_STRCO 30S RIBOSOMAL PROTEIN S7 from Streptomyces coelicolor (156 aa); etc. Contains PS00052 Ribosomal protein S7 signature. BELONGS TO THE S7P FAMILY OF RIBOSOMAL PROTEINS. X2BFT8,Q53539 No information pathways Rv0683 NC_002945.3 Mycobrowser_v2 CDS 777355 780249 . - 0 Mb0695c mmpL5 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL5 Mb0695c, mmpL5, len: 964 aa. Equivalent to Rv0676c,len: 964 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 964 aa overlap). Probable mmpL5,conserved transmembrane transport protein (see first citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. MTV037_14, MTCY98_8,MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19,etc. Also similar to other Mycobacterial mmpl proteins e.g. P54881|MML4_MYCLE PUTATIVE MEMBRANE PROTEIN MMPL4 from Mycobacterium leprae (959 aa), FASTA scores: opt: 3991, E(): 0, (62.8% identity in 933 aa overlap); etc. BELONGS TO THE MMPL FAMILY. TBparse score is 0.884. Q7U1H4 No NC_002945.3 Mycobrowser_v2 CDS 780246 780674 . - 0 Mb0696c mmpS5 POSSIBLE CONSERVED MEMBRANE PROTEIN MMPS5 Mb0696c, mmpS5, len: 142 aa. Equivalent to Rv0677c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Possible mmpS5,conserved membrane protein (see first citation below),highly similar to other Mycobacterial proteins e.g. P54880|MMS4_MYCLE PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 443,E(): 1.4e-23, (47.1% identity in 155 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis. BELONGS TO THE MMPS FAMILY. TBparse score is 0.901. X2BFV2,P65381 No NC_002945.3 Mycobrowser_v2 CDS 780759 781256 . + 0 Mb0697 conserved protein Mb0697, -, len: 165 aa. Equivalent to Rv0678, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical protein, showing weak similarity with AL049754|SCH10_10 hypothetical protein from Streptomyces coelicolor (152 aa), FASTA scores: opt: 149, E(): 0.0018,(22.9% identity in 140 aa overlap). TBparse score is 0.910. Q7U1H3 No conserved hypotheticals Rv0678 NC_002945.3 Mycobrowser_v2 CDS 781312 781809 . - 0 Mb0698c conserved threonine rich protein Mb0698c, -, len: 165 aa. Equivalent to Rv0679c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical Thr-rich protein, similar in part to neighboring ORF Rv0680c (124 aa), FASTA score: (35.1% identity in 131 aa overlap); and Rv0314c (220 aa). Contains probable N-terminal signal sequence. TBparse score is 0.894. Q7U1H2 No conserved hypotheticals Rv0679c NC_002945.3 Mycobrowser_v2 CDS 781811 782185 . - 0 Mb0699c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0699c, -, len: 124 aa. Equivalent to Rv0680c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Possible conserved transmembrane protein, showing similarity with C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved hypothetical protein from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 175, E(): 2.2e-05, (31.4% identity in 102 aa overlap). Also some similarity to upstream ORF Rv0679c|MTV040.07c CONSERVED HYPOTHETICAL THREONINE RICH PROTEIN (124 aa), FASTA score: (35.1% identity in 131 aa overlap). Contains probable N-terminal signal sequence. Q7U1H1 No cell wall and cell processes Rv0680c NC_002945.3 Mycobrowser_v2 CDS 782490 783080 . + 0 Mb0700 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0700, -, len: 196 aa. Equivalent to Rv0681, len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable transcription regulator, TetR family, similar to others and especially many tetracycline repressors e.g. T34657 probable transcription regulator from Streptomyces coelicolor (189 aa); AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator from Bacillus subtilis (191 aa), FASTA scores: opt: 213,E(): 1.6e-07, (28.8% identity in 153 aa overlap); P09164|TER4_ECOLI TETRACYCLINE REPRESSOR PROTEIN from Escherichia coli (217 aa), FASTA scores: opt: 145, E(): 0.0068, (39.0% identity in 59 aa overlap); etc. Contains helix-turn-helix motif at aa 28-49 (Score 1020, +2.66 SD). Q7U1H0 No regulatory proteins Rv0681 NC_002945.3 Mycobrowser_v2 CDS 783329 783703 . + 0 Mb0701 rpsL 30s ribosomal protein s12 rpsl Mb0701, rpsL, len: 124 aa. Equivalent to Rv0682,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Probable rpsL, 30S ribosomal protein S12 (see citations below), equivalent to others from Mycobacteria e.g. P41195|RS12_MYCSM 30S RIBOSOMAL PROTEIN S12 from Mycobacterium smegmatis (124 aa); P51999|RS12_MYCAV 30S RIBOSOMAL PROTEIN S12 from Mycobacterium avium (124 aa); etc. Also highly similar to others from other organisms e.g. P97222|RS12_STRCO 30S RIBOSOMAL PROTEIN S12 from Streptomyces roseosporus,lividans and coelicolor (123 aa); etc. Contains PS00055 Ribosomal protein S12 signature. BELONGS TO THE S12P FAMILY OF RIBOSOMAL PROTEINS. X2BFV8,Q53538 No information pathways Rv0682 NC_002945.3 Mycobrowser_v2 CDS 824688 825416 . + 0 Mb0751 gcn5-related n-acetyltransferase Mb0751, -, len: 242 aa. Equivalent to Rv0730, len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical protein, only equivalent to Z98756|MLCB2492_26 HYPOTHETICAL PROTEIN from Mycobacterium leprae (227 aa), FASTA scores: opt: 1180, E(): 0, (83.5% identity in 218 aa overlap). O53794 No intermediary metabolism and respiration Rv0730 NC_002945.3 Mycobrowser_v2 CDS 784254 786359 . + 0 Mb0703 fusA1 PROBABLE ELONGATION FACTOR G FUSA1 (EF-G) Mb0703, fusA1, len: 701 aa. Equivalent to Rv0684,len: 701 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 701 aa overlap). Probable fusA1,elongation factor G, equivalent to P30767|EFG_MYCLE|S31150 translation elongation factor EF-G from Mycobacterium leprae (701 aa), FASTA scores: opt: 2521, E(): 0, (88.2% identity in 432 aa overlap). Also highly similar to others e.g. CAB81852.1|AL161691 elongation factor G from Streptomyces coelicolor (708 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. Note that previously known as fusA. X2BFQ9,P0A557 No NC_002945.3 Mycobrowser_v2 CDS 786590 787780 . + 0 Mb0704 tuf probable iron-regulated elongation factor tu tuf (ef-tu) Mb0704, tuf, len: 396 aa. Equivalent to Rv0685,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Probable tuf,elongation factor EF-Tu, equivalent to JC2262 translation elongation factor Tu from Mycobacterium leprae (396 aa). Also highly similar to others e.g. P42439|EFTU_CORGL ELONGATION FACTOR TU (EF-TU) from Corynebacterium glutamicum (396 aa); etc. Contains PS00017 ATP/GTP-binding site motif A, and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-TU/EF-1A SUBFAMILY. X2BFM6,P0A559 No information pathways Rv0685 NC_002945.3 Mycobrowser_v2 CDS 788868 789695 . + 0 Mb0706 probable short-chain type dehydrogenase/reductase Mb0706, -, len: 275 aa. Equivalent to Rv0687, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases (generally SDR family) e.g. U17129|RSU17129_7 short-chain dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 1112, E(): 0, (61.2% identity in 268 aa overlap); MMU34072_2 steroid dehydrogenase from Musmus culus (260 aa), FASTA scores: opt: 390, E(): 2.2e-17, (34.1% identity in 267 aa overlap); etc. Also similar to MTV002_16|O33292|Rv2750 DEHYDROGENASE from Mycobacterium tuberculosis (272 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Q7U1G8 No intermediary metabolism and respiration Rv0687 NC_002945.3 Mycobrowser_v2 CDS 789709 790929 . + 0 Mb0707 PUTATIVE FERREDOXIN REDUCTASE Mb0707, -, len: 406 aa. Equivalent to Rv0688, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Putative ferredoxin reductase (EC 1.-.-.-), highly similar to others e.g. BAB55881.1|AB054975 ferredoxin reductase from Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); PPU24215_8|Q51973 P-CUMATE DIOXYGENASE FERREDOXIN REDUCTASE SUBUNIT from Pseudomonas putida (402 aa), FASTA scores: opt: 738, E(): 0, (38.8% identity in 330 aa overlap); etc. Also similar to Rv0253 and Rv1869c from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY. Q7U1G7 No intermediary metabolism and respiration Rv0688 NC_002945.3 Mycobrowser_v2 CDS 790926 791180 . - 0 Mb0708c HYPOTHETICAL PROTEIN Mb0708c, -, len: 84 aa. Equivalent to Rv0689c, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Hypothetical unknown protein. Q7U1G6 No conserved hypotheticals Rv0689c NC_002945.3 Mycobrowser_v2 CDS 791793 792842 . - 0 Mb0709c CONSERVED HYPOTHETICAL PROTEIN Mb0709c, -, len: 349 aa. Equivalent to Rv0690c,len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Conserved hypothetical protein, showing similarity with NP_386956.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063 AGR_L_1570p from Agrobacterium tumefaciens (346 aa); NP_421938.1|NC_002696 conserved hypothetical protein from Caulobacter crescentus (370 aa). Q7U1G5 No conserved hypotheticals Rv0690c NC_002945.3 Mycobrowser_v2 CDS 792839 793435 . - 0 Mb0710c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0710c, -, len: 198 aa. Equivalent to Rv0691c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 198 aa overlap). Rv0691c,(MTCY210.08c), len: 198 aa. Probable transcriptional regulator, highly similar to AAC77476.1|U17129 unknown protein from Rhodococcus erythropolis (185 aa); and showing similarity with putative regulatory proteins eg STMTCREP_1|TCMR_STRGA|P39885 tetracenomycin c transcriptional repressor from Streptomyces glaucescens (226 aa), FASTA scores: opt: 178, E(): 8.5e-06, (27.9% identity in 201 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and probable helix-turn helix motifs from aa 34-55 (Score 1100, +2.93 SD) and 151-172 (Score 1124, +3.02 SD). Q7U1G4 No regulatory proteins Rv0691c NC_002945.3 Mycobrowser_v2 CDS 793427 793615 . + 0 Mb0710A Mycofactocin precursor protein Mb0710A, len: 62 aa. Equivalent to Rv0691A len: 62 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Mycofactocin precursor protein. X2BFW7 No intermediary metabolism and respiration Rv0691A NC_002945.3 Mycobrowser_v2 CDS 793600 793929 . + 0 Mb0711 CONSERVED HYPOTHETICAL PROTEIN Mb0711, -, len: 109 aa. Equivalent to Rv0692, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Conserved hypothetical protein, highly similar to U17129|RSU17129_3|AAC77477.1 unknown protein from Rhodococcus erythropolis (95 aa), FASTA scores: opt: 393,E(): 8.8e-22, (68.2% identity in 88 aa overlap). Q7U1G3 No conserved hypotheticals Rv0692 NC_002945.3 Mycobrowser_v2 CDS 793926 795101 . + 0 Mb0712 pqqE PROBABLE COENZYME PQQ SYNTHESIS PROTEIN E PQQE (COENZYME PQQ SYNTHESIS PROTEIN III) Mb0712, pqqE, len: 391 aa. Equivalent to Rv0693,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 391 aa overlap). Probable pqqE (alternate gene name: pqqIII), coenzyme PQQ synthesis protein E, similar to others AE001109_9|O30258|PQQE COENZYME PQQ SYNTHESIS PROTEIN from Archaeoglobus fulgidus (375 aa), FASTA scores: E(): 1.6e-16, (28.1% identity in 377 aa overlap); PQQE_ACICA|P07782 coenzyme pqq synthesis protein e from Acinetobacter calcoaceticus (384 aa), FASTA scores: opt: 302, E(): 1.8e-12, (23.9% identity in 377 aa overlap); etc. Also similar to C-terminus of heme biosynthesis proteins e.g. O28270|AF2009 HEME BIOSYNTHESIS PROTEIN (NIRJ-2) from Archaeoglobus fulgidus (468 aa). Note that also highly similar to U17129|RSU17129_4|AAC77478.1 unknown protein from Rhodococcus erythropolis (405 aa), FASTA scores: opt: 1997, E(): 0, (73.3% identity in 390 aa overlap). COULD BELONG TO THE MOAA / NIFB / PQQE FAMILY. Q7U1G2 No intermediary metabolism and respiration Rv0693 NC_002945.3 Mycobrowser_v2 CDS 795104 796294 . + 0 Mb0713 lldD1 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD1 Mb0713, lldD1, len: 396 aa. Equivalent to Rv0694,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Possible lldD1,L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar to NP_302368.1|NC_002677 L-lactate dehydrogenase from Mycobacterium leprae (414 aa). Also similar to others e.g. NP_384560.1|NC_003047 PUTATIVE L-LACTATE DEHYDROGENASE (CYTOCHROME) PROTEIN from Sinorhizobium meliloti (403 aa); NP_251072.1|NC_002516 L-lactate dehydrogenase from Pseudomonas aeruginosa (383 aa); P33232|LLDD_ECOLI L-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa), FASTA scores: opt: 697, E(): 0, (34.5 identity in 380 aa overlap); etc; and also similar to other oxidoreductases. Note that also highly similar to RSU17129_5|AAC77479.1|U17129 unknown protein from Rhodococcus erythropolis (392 aa), FASTA scores: opt: 2006, E(): 0, (74.1% identity in 386 aa overlap). Also similar to lldD2|Rv1872c|MTCY180.46|MTCY359.01 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis (414 aa). BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY. Q7U1G1 No NC_002945.3 Mycobrowser_v2 CDS 1600239 1601066 . - 0 Mb1463c CONSERVED HYPOTHETICAL PROTEIN Mb1463c, -, len: 275 aa. Equivalent to Rv1428c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins from M. tuberculosis e.g. Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: opt: 355, E(): 5e-16, (32.6% identity in 273 aa overlap); and Rv1920. Q7U036 No conserved hypotheticals Rv1428c NC_002945.3 Mycobrowser_v2 CDS 796484 797239 . + 0 Mb0714 CONSERVED HYPOTHETICAL PROTEIN Mb0714, -, len: 251 aa. Equivalent to Rv0695, len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Conserved hypothetical protein, similar to many creatinine amidohydrolases or hypothetical proteins e.g. NP_443048.1|NC_000911 creatinine amidohydrolase from Synechococcus sp. PCC 6803 (273 aa); NP_466169.1|NC_003210 protein similar to creatinine amidohydrolase from Listeria monocytogenes (249 aa); T35153|SC5A7.04c hypothetical protein from Streptomyces coelicolor (273 aa); etc. Note that highly similar to RSU17129_10|AAC77474.1|U17129 unknown protein from Rhodococcus erythropolis (230 aa),FASTA scores: opt: 693, E(): 0, (55.7% identity in 237 aa overlap). Q7U1G0 No conserved hypotheticals Rv0695 NC_002945.3 Mycobrowser_v2 CDS 797288 798700 . + 0 Mb0715 PROBABLE MEMBRANE SUGAR TRANSFERASE Mb0715, -, len: 470 aa. Equivalent to Rv0696, len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 470 aa overlap). Probable membrane sugar transferase (EC 2.-.-.-), similar (except in N-terminus) to NP_069157.1|NC_000917 glycosyl transferase from Archaeoglobus fulgidus (324 aa); NP_279985.1|NC_002607 rhamnosyl transferase from Halobacterium sp. NRC-1 (299 aa); NP_059113.1|NM_017417 polypeptide N-acetylgalactosaminyltransferase 8 from (637 aa). Note that also highly similar to P46370|YTH1_RHOER HYPOTHETICAL 55.3 KDA PROTEIN from Rhodococcus erythropolis (513 aa), FASTA scores: opt: 1514, E(): 0,(51.8% identity in 469 aa overlap). Q7U1F9 No intermediary metabolism and respiration Rv0696 NC_002945.3 Mycobrowser_v2 CDS 798702 800141 . + 0 Mb0716 PROBABLE DEHYDROGENASE Mb0716, -, len: 479 aa. Equivalent to Rv0697, len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Probable dehydrogenase (EC 1.-.-.-), highly similar to P30772|YTUR_MYCLE HYPOTHETICAL 24 KD PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 557,E(): 1.7e-28, (46.2% identity in 223 aa overlap). Also highly similar to P46371|YTH2_RHOER HYPOTHETICAL 53.0 KDA GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa); and similar to many dehydrogenases e.g. NP_250814.1|NC_002516 probable dehydrogenase from Pseudomonas aeruginosa (545 aa); BAA13145.1|D86622 FAD dependent L-sorbose dehydrogenase from Gluconobacter oxydans (531 aa); etc. Also similar to Rv1279 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. Q7U1F8 No intermediary metabolism and respiration Rv0697 NC_002945.3 Mycobrowser_v2 CDS 808157 808603 . + 0 Mb0731 atsAa POSSIBLE ARYLSULFATASE ATSAa [FIRST PART] (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE) Mb0731, atsAa, len: 148 aa. Equivalent to 5' end of Rv0711, len: 787 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 148 aa overlap). Possible atsA, arylsulfatase (EC 3.1.6.1), similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439,E(): 2.9e-21, (30.8% identity in 552 aa overlap); etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases signature 1, and PS00149 Sulfatases signature 2. BELONGS TO THE SULFATASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t),introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb. Q7U1F3 No NC_002945.3 Mycobrowser_v2 CDS 819361 820266 . - 0 Mb0746c CONSERVED HYPOTHETICAL PROTEIN Mb0746c, -, len: 301 aa. Equivalent to Rv0725c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c, Rv0731c,Rv3399, etc, e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical 36.1 kd protein cy31.21c (325 aa), FASTA scores: opt: 600,E(): 3.9e-32, (43.8% identity in 219 aa overlap). X2BFZ0,Q7U1E7 No conserved hypotheticals Rv0725c NC_002945.3 Mycobrowser_v2 CDS 800602 800931 . + 0 Mb0717 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb0717, -, len: 109 aa. Equivalent to 5' end of Rv0698, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 106 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 2.1e-07, (54.8% identity in 73 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718. Q7U1F7 No NC_002945.3 Mycobrowser_v2 CDS 800979 801212 . + 0 Mb0718 CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb0718, -, len: 77 aa. Equivalent to 3' end of Rv0698, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 77 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 2.1e-07, (54.8% identity in 73 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718. Q7U1F6 No NC_002945.3 Mycobrowser_v2 CDS 801397 801618 . + 0 Mb0719 HYPOTHETICAL PROTEIN Mb0719, -, len: 73 aa. Equivalent to Rv0699, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Hypothetical unknown protein. Q7U1F5 No conserved hypotheticals Rv0699 NC_002945.3 Mycobrowser_v2 CDS 802255 802560 . + 0 Mb0720 rpsJ 30S RIBOSOMAL PROTEIN S10 RPSJ (TRANSCRIPTION ANTITERMINATION FACTOR NUSE) Mb0720, rpsJ, len: 101 aa. Equivalent to Rv0700,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). rpsJ (alternate gene name: nusE), 30S ribosomal protein S10 (see first citation below), equivalent to RS10_MYCLE P307653 30S ribosomal protein S10 from Mycobacterium leprae (101 aa), FASTA scores: opt: 645, E(): 0, (97.0% identity in 101 aa overlap). Also highly similar to others e.g. CAB82069.1|AL161803 30S ribosomal protein S10 from Streptomyces coelicolor (102 aa); etc. Contains PS00361 Ribosomal protein S10 signature. BELONGS TO THE S10P FAMILY OF RIBOSOMAL PROTEINS. X2BFX5,P0A5X1 No information pathways Rv0700 NC_002945.3 Mycobrowser_v2 CDS 802577 803230 . + 0 Mb0721 rplC 50s ribosomal protein l3 rplc Mb0721, rplC, len: 217 aa. Equivalent to Rv0701,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Probable rplC, 50S ribosomal protein L3, equivalent to O06044|RL3_MYCBO 50S RIBOSOMAL PROTEIN L3 from Mycobacterium bovis BCG (217 aa); and P30762|RL3_MYCLE 50S RIBOSOMAL PROTEIN L3 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. CAB82070.1|AL161803 50S ribosomal protein L3 from Streptomyces coelicolor (214 aa); P52860|RL3_THETH ribosomal protein l3 from Thermus aquaticus (206 aa),FASTA scores: opt: 717, E(): 0, (55.2% identity in 210 aa overlap); etc. Contains PS00474 Ribosomal protein L3 signature. BELONGS TO THE L3P FAMILY OF RIBOSOMAL PROTEINS. X2BFW2,P60441 No information pathways Rv0701 NC_002945.3 Mycobrowser_v2 CDS 2130721 2130939 . + 0 Mb1926 CONSERVED HYPOTHETICAL PROTEIN Mb1926, -, len: 72 aa. Equivalent to Rv1893, len: 72 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Conserved hypothetical protein. Equivalent to MLCB561.11|AL049571 hypothetical protein from Mycobacterium leprae (74 aa), FASTA scores: opt: 317, E(): 4.6e-15, (69.4% identity in 72 aa overlap). Q7TZC4 No conserved hypotheticals Rv1893 NC_002945.3 Mycobrowser_v2 CDS 803230 803901 . + 0 Mb0722 rplD 50s ribosomal protein l4 rpld Mb0722, rplD, len: 223 aa. Equivalent to Rv0702,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Probable rplD, 50S ribosomal protein L4, equivalent to O06045|RL4_MYCBO 50S RIBOSOMAL PROTEIN L4 from Mycobacterium bovis BCG (223 aa); O06114|RL4_MYCSM 50S RIBOSOMAL PROTEIN L4 from Mycobacterium smegmatis (215 aa); and MLCB2492_3 50S ribosomal protein L4 from Mycobacterium leprae (230 aa). Also highly similar to others e.g. CAB82071.1|AL161803 50S ribosomal protein L4 from Streptomyces coelicolor (219 aa); P28601|RL4_BACST 50s ribosomal protein L4 from Bacillus stearothermophilus (207 aa), FASTA scores: opt: 522, E(): 3.5e-26, (42.4% identity in 198 aa overlap); etc. BELONGS TO THE L4P FAMILY OF RIBOSOMAL PROTEINS. X2BFS0,P60728 No information pathways Rv0702 NC_002945.3 Mycobrowser_v2 CDS 803901 804203 . + 0 Mb0723 rplW 50s ribosomal protein l23 rplw Mb0723, rplW, len: 100 aa. Equivalent to Rv0703,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Probable rplW, 50S ribosomal protein L23, equivalent to O06046|RL23_MYCBO 50S RIBOSOMAL PROTEIN L23 from Mycobacterium bovis BCG (100 aa); and MLCB2492_4 50S RIBOSOMAL PROTEIN L23 from Mycobacterium leprae (100 aa). Also highly similar to others e.g. CAB82072.1|AL161803 50S ribosomal protein L23 from Streptomyces coelicolor (139 aa) (N-terminus longer); P04454|RL23_BACST 50s ribosomal protein L23 from Bacillus stearothermophilus (95 aa), FASTA scores: opt: 275, E(): 1.4e-13, (50.5% identity in 95 aa overlap); etc. Contains PS00050 Ribosomal protein L23 signature. BELONGS TO THE L23P FAMILY OF RIBOSOMAL PROTEINS. X2BFQ3,O06046 No information pathways Rv0703 NC_002945.3 Mycobrowser_v2 CDS 804350 805192 . + 0 Mb0724 rplB 50s ribosomal protein l2 rplb Mb0724, rplB, len: 280 aa. Equivalent to Rv0704,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable rplB, 50S ribosomal protein L2, equivalent to O06047|RL2_MYCBO 50S RIBOSOMAL PROTEIN L2 from Mycobacterium bovis BCG (280 aa); and MLCB2492_5M 50S RIBOSOMAL PROTEIN L2 from Mycobacterium leprae (280 aa). Also highly similar to others e.g. CAB82073.1|AL161803 50S ribosomal protein L2 from Streptomyces coelicolor (278 aa); P42919|RL2_BACSU 50s ribosomal protein l2 (bl2) from Bacillus subtilis (276 aa), FASTA scores: opt: 1179, E(): 0, (61.1% identity in 275 aa overlap); etc. Contains PS00467 Ribosomal protein L2 signature. BELONGS TO THE L2P FAMILY OF RIBOSOMAL PROTEINS. X2BFW0,O06047 No information pathways Rv0704 NC_002945.3 Mycobrowser_v2 CDS 805233 805514 . + 0 Mb0725 rpsS 30s ribosomal protein s19 rpss Mb0725, rpsS, len: 93 aa. Equivalent to Rv0705,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable rpsS, 30S ribosomal protein S19, equivalent to S36895 ribosomal protein S19 from Mycobacterium bovis (93 aa), FASTA scores: opt: 623, E(): 0, (98.9% identity in 93 aa overlap); and NP_302261.1|NC_002677 30S ribosomal protein S19 from Mycobacterium leprae (93 aa). Also highly similar to others e.g. CAB82074.1|AL161803 30S ribosomal protein S19 from Streptomyces coelicolor (93 aa); etc. Contains PS00323 Ribosomal protein S19 signature. BELONGS TO THE S19P FAMILY OF RIBOSOMAL PROTEINS. X2BFY0,P0A5X5 No information pathways Rv0705 NC_002945.3 Mycobrowser_v2 CDS 1619634 1620044 . - 0 Mb1479c unknown protein Mb1479c, -, len: 136 aa. Equivalent to Rv1444c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Hypothetical unknown protein. Q7U024 No conserved hypotheticals Rv1444c NC_002945.3 Mycobrowser_v2 CDS 806104 806928 . + 0 Mb0727 rpsC 30s ribosomal protein s3 rpsc Mb0727, rpsC, len: 274 aa. Equivalent to Rv0707,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Probable rpsC, 30S ribosomal protein S3, equivalent to O06048|RS3_MYCBO|MBS10OPER_8 30S RIBOSOMAL PROTEIN S3 from Mycobacterium bovis BCG (274 aa); and MLCB2492_8 30S RIBOSOMAL PROTEIN S3 from Mycobacterium leprae (281 aa). Also highly similar to others e.g. CAB82076.1|AL161803 30S ribosomal protein S3 from Streptomyces coelicolor (277 aa); P21465|RS3_BACSU 30s ribosomal protein s3 (bs3) (bs2) from Bacillus subtilis (217 aa), FASTA scores: opt: 794,E(): 0, (52.8% identity in 212 aa overlap); etc. BELONGS TO THE S3P FAMILY OF RIBOSOMAL PROTEINS. X2BFS3,P0A5X7 No information pathways Rv0707 NC_002945.3 Mycobrowser_v2 CDS 806932 807348 . + 0 Mb0728 rplP 50s ribosomal protein l16 rplp Mb0728, rplP, len: 138 aa. Equivalent to Rv0708,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Probable rplP, 50S ribosomal protein L16, equivalent to O06049|RL16_MYCBO|MBS10OPER_9 50S RIBOSOMAL PROTEIN L16 from Mycobacterium bovis BCG (138 aa); and MLCB2492_9 50S RIBOSOMAL PROTEIN L16 from Mycobacterium leprae (138 aa). Also highly similar to others e.g. CAB82077.1|AL161803 50S ribosomal protein L16 from Streptomyces coelicolor (139 aa); P14577|RL16_BACSU 50s ribosomal protein l16 from Bacillus subtilis (144 aa), FASTA scores: opt: 600, E(): 0, (63.2% identity in 136 aa overlap); etc. Contains PS00701 Ribosomal protein L16 signature 2. BELONGS TO THE L16P FAMILY OF RIBOSOMAL PROTEINS. X2BFR0,O06049 No information pathways Rv0708 NC_002945.3 Mycobrowser_v2 CDS 807348 807581 . + 0 Mb0729 rpmC 50s ribosomal protein l29 rpmc Mb0729, rpmC, len: 77 aa. Equivalent to Rv0709,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Probable rpmC, 50S ribosomal protein L29, equivalent to O06050|RL29_MYCBO|MBS10OPER_10 50S RIBOSOMAL PROTEIN L29 from Mycobacterium bovis BCG (75 aa); and O32989|RL29_MYCLE|MLCB2492_10 50S RIBOSOMAL PROTEIN L29 from Mycobacterium leprae (80 aa). Also highly similar to others e.g. Q9L0D2|RL29_STRCO 50S RIBOSOMAL PROTEIN L29 from Streptomyces coelicolor (74 aa); P12873|RL29_BACSU 50s ribosomal protein l29 from Bacillus subtilis (66 aa),FASTA scores: opt: 225, E(): 8.3e-11, (58.6% identity in 58 aa overlap); etc. BELONGS TO THE L29P FAMILY OF RIBOSOMAL PROTEINS. X2BFW6,O06050 No information pathways Rv0709 NC_002945.3 Mycobrowser_v2 CDS 807578 807988 . + 0 Mb0730 rpsQ 30s ribosomal protein s17 rpsq Mb0730, rpsQ, len: 136 aa. Equivalent to Rv0710,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Probable rpsQ, 30S ribosomal protein S17, equivalent to O06051|RS17_MYCBO 30S|MBS10OPER_11 30S RIBOSOMAL PROTEIN S17 from Mycobacterium bovis BCG (136 aa); and MLCB2492_11 30S RIBOSOMAL PROTEIN S17 from Mycobacterium leprae (126 aa). Also highly similar to others e.g. CAB82079.1|AL161803 30S ribosomal protein S17 from Streptomyces coelicolor (95 aa); P12874|RS17_BACSU 30s ribosomal protein s17 (bs 16) from Bacillus subtilis (86 aa), FASTA scores: opt: 305,E(): 1.6e-11, (60.5% identity in 81 aa overlap); etc. Contains PS00056 Ribosomal protein S17 signature. BELONGS TO THE S17P FAMILY OF RIBOSOMAL PROTEINS. X2BFY6,O06051 No information pathways Rv0710 NC_002945.3 Mycobrowser_v2 CDS 2194218 2194763 . + 0 Mb1992 HYPOTHETICAL PROTEIN Mb1992, -, len: 181 aa. Equivalent to Rv1957, len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Hypothetical unknown protein. Q7TZ75 No conserved hypotheticals Rv1957 NC_002945.3 Mycobrowser_v2 CDS 808610 810520 . + 0 Mb0732 atsAb POSSIBLE ARYLSULFATASE ATSAb [SECOND PART] (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE) Mb0732, atsAb, len: 636 aa. Equivalent to 3' end of Rv0711, len: 787 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 636 aa overlap). Possible atsA, arylsulfatase (EC 3.1.6.1), similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439,E(): 2.9e-21, (30.8% identity in 552 aa overlap); etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases signature 1, and PS00149 Sulfatases signature 2. BELONGS TO THE SULFATASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t),introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb. Q7U1F2 No NC_002945.3 Mycobrowser_v2 CDS 810568 811467 . + 0 Mb0733 conserved protein Mb0733, -, len: 299 aa. Equivalent to Rv0712, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Conserved hypothetical protein, similar to others e.g. NP_106128.1|NC_002678 hypothetical protein from Mesorhizobium loti (372 aa); D90901_33|P72841 HYPOTHETICAL 48.1 KD PROTEIN from Synechocystis sp (410 aa), FASTA scores: E(): 1.1e-07, (28.8% identity in 299 aa overlap); etc. Slight similarity to carboxykinases. Similar to C-terminal part of Rv3703c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (425 aa). Q7U1F1 No conserved hypotheticals Rv0712 NC_002945.3 Mycobrowser_v2 CDS 811768 812709 . + 0 Mb0734 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0734, -, len: 313 aa. Equivalent to Rv0713, len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 313 aa overlap). Probable conserved transmembrane protein, similar to Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis (284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35.8% identity in 282 aa overlap); MLCB2492_12|O32991 HYPOTHETICAL 10.7 KD PROTEIN from Mycobacterium leprae (95 aa). Q7U1F0 No cell wall and cell processes Rv0713 NC_002945.3 Mycobrowser_v2 CDS 813195 813563 . + 0 Mb0735 rplN 50s ribosomal protein l14 rpln Mb0735, rplN, len: 122 aa. Equivalent to Rv0714,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable rplN, 50S ribosomal protein L14, equivalent to O32993|MLCB2492_14|ML1849|RL14_MYCLE 50S RIBOSOMAL PROTEIN L14 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82080.1|AL161803 50S ribosomal protein L14 from Streptomyces coelicolor (122 aa); P33100|RL14_MICLU 50s ribosomal protein L14 from Micrococcus luteus (122 aa), FASTA scores: opt: 674, E(): 0, (85.2% identity in 122 aa overlap); etc. Contains PS00049 Ribosomal protein L14 signature. BELONGS TO THE L14P FAMILY OF RIBOSOMAL PROTEINS. X2BFZ2,P66070 No information pathways Rv0714 NC_002945.3 Mycobrowser_v2 CDS 815762 816130 . + 0 Mb0741 rplR 50s ribosomal protein l18 rplr Mb0741, rplR, len: 122 aa. Equivalent to Rv0720,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable rplR, 50S ribosomal protein L18, equivalent to O32999|MLCB2492_20|RL18_MYCLE 50S RIBOSOMAL PROTEIN L18 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82086.1|AL161803 50S ribosomal protein L18 from Streptomyces coelicolor (127 aa); P33102|RL18_MICLU 50s ribosomal protein L18 from Micrococcus luteus (119 aa), FASTA scores: opt: 447, E(): 8.7e-24, (60.4% identity in 111 aa overlap); etc. BELONGS TO THE L18P FAMILY OF RIBOSOMAL PROTEINS. X2BFY4,P66077 No information pathways Rv0720 NC_002945.3 Mycobrowser_v2 CDS 813564 813881 . + 0 Mb0736 rplX 50s ribosomal protein l24 rplx Mb0736, rplX, len: 105 aa. Equivalent to Rv0715,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Probable rplX, 50S ribosomal protein L24, equivalent to O32994|MLCB2492_15 50S RIBOSOMAL PROTEIN L24 from Mycobacterium leprae (105 aa). Also highly similar to others e.g. CAB82081.1|AL161803 50S ribosomal protein L24 from Streptomyces coelicolor (107 aa); P12876|RL24_BACSU 50s ribosomal protein L24 (bl23) from Bacillus subtilis (103 aa), FASTA scores: opt: 363, E(): 1.8e-18, (56.7% identity in 104 aa overlap); etc. Contains PS01108 Ribosomal protein L24 signature. BELONGS TO THE L24P FAMILY OF RIBOSOMAL PROTEINS. X2BFX8,P60628 No information pathways Rv0715 NC_002945.3 Mycobrowser_v2 CDS 813881 814444 . + 0 Mb0737 rplE 50s ribosomal protein l5 rple Mb0737, rplE, len: 187 aa. Equivalent to Rv0716,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable rplE, 50S ribosomal protein L5, equivalent to MLCB2492_16 50S RIBOSOMAL PROTEIN L5 from Mycobacterium leprae (187 aa). Also highly similar to others e.g. CAB82082.1|AL161803 50S ribosomal protein L5 from Streptomyces coelicolor (185 aa); P33098|RL5_MICLU 50S RIBOSOMAL PROTEIN L5 from Micrococcus luteus (191 aa), FASTA scores: opt: 930, E(): 0, (73.8% identity in 183 aa overlap); etc. BELONGS TO THE L5P FAMILY OF RIBOSOMAL PROTEINS. X2BFT0,P62402 No information pathways Rv0716 NC_002945.3 Mycobrowser_v2 CDS 814449 814634 . + 0 Mb0738 rpsN1 30s ribosomal protein s14 rpsn1 Mb0738, rpsN1, len: 61 aa. Equivalent to Rv0717,len: 61 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 61 aa overlap). Probable rpsN1, 30S ribosomal protein S14, equivalent to MLCB2492_17|O32996 RIBOSOMAL PROTEIN S14 from Mycobacterium leprae (61 aa). Also highly similar to others e.g. CAB82083.1|AL161803 30S ribosomal protein S14 from Streptomyces coelicolor (61 aa); P24320|RS14_THETH 30s ribosomal protein S14 from Thermus aquaticus (subsp. thermophilus) (60 aa), FASTA scores: opt: 316, E(): 2e-19,(70.0% identity in 60 aa overlap); etc. Contains PS00527 Ribosomal protein S14 signature. BELONGS TO THE S14P FAMILY OF RIBOSOMAL PROTEINS. Note that previously known as rpsN. X2BFS2,P0A5X3 No information pathways Rv0717 NC_002945.3 Mycobrowser_v2 CDS 814798 815196 . + 0 Mb0739 rpsH 30s ribosomal protein s8 rpsh Mb0739, rpsH, len: 132 aa. Equivalent to Rv0718,len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Probable rpsH, 30S ribosomal protein S8, equivalent to O32997|MLCB2492_18 30S RIBOSOMAL PROTEIN S8 from Mycobacterium leprae (132 aa). Also highly similar to others e.g. CAB82084.1|AL161803 30S ribosomal protein S8 from Streptomyces coelicolor (132 aa); P33106|RS8_MICLU 30s ribosomal protein S8 from Micrococcus luteus (132 aa), FASTA scores: opt: 669, E(): 0, (77.3% identity in 132 aa overlap); etc. Contains PS00053 Ribosomal protein S8 signature. BELONGS TO THE S8P FAMILY OF RIBOSOMAL PROTEINS. X2BFX6,P66626 No information pathways Rv0718 NC_002945.3 Mycobrowser_v2 CDS 815220 815759 . + 0 Mb0740 rplF 50s ribosomal protein l6 rplf Mb0740, rplF, len: 179 aa. Equivalent to Rv0719,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable rplF, 50S ribosomal protein L6, equivalent to O32998|MLCB2492_19 50S RIBOSOMAL PROTEIN L6 from Mycobacterium leprae (179 aa). Also highly similar to others e.g. P46786|RL6_STRCO|CAB82085.1|AL161803|SCD31.42 50S ribosomal protein L6 from Streptomyces coelicolor (179 aa), FASTA scores: opt: 872, E(): 0, (70.4% identity in 179 aa overlap); etc. Contains PS00525 Ribosomal protein L6 signature 1. BELONGS TO THE L6P FAMILY OF RIBOSOMAL PROTEINS. X2BFZ9,P66312 No information pathways Rv0719 NC_002945.3 Mycobrowser_v2 CDS 816150 816812 . + 0 Mb0742 rpsE 30s ribosomal protein s5 rpse Mb0742, rpsE, len: 220 aa. Equivalent to Rv0721,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable rpsE, 30S ribosomal protein S5, equivalent to MLCB2492_21 RIBOSOMAL PROTEIN S5 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. P46790|RS5_STRCO 30s ribosomal protein S5 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 889, E(): 0, (82.1% identity in 162 aa overlap); etc. Note N-terminus is extented compared to other rpsE genes. Contains PS00585 Ribosomal protein S5 signature, PTS HPr component phosphorylation sites signature. BELONGS TO THE S5P FAMILY OF RIBOSOMAL PROTEINS. X2BFT3,P66575 No information pathways Rv0721 NC_002945.3 Mycobrowser_v2 CDS 816815 817012 . + 0 Mb0743 rpmD 50s ribosomal protein l30 rpmd Mb0743, rpmD, len: 65 aa. Equivalent to Rv0722,len: 65 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 65 aa overlap). Probable rpmD, 50S ribosomal protein L30, equivalent to O33001 RIBOSOMAL PROTEIN L30 from Mycobacterium leprae (71 aa). Also highly similar to others e.g. P46789|RL30_STRCO 50S RIBOSOMAL PROTEIN L30 from Streptomyces coelicolor (60 aa); P02430|RL30_ECOLI 50S ribosomal protein L30 from Escherichia coli (58 aa), FASTA scores: opt: 168, E(): 1.5e-13, (53.7% identity in 54 aa overlap); etc. BELONGS TO THE L30P FAMILY OF RIBOSOMAL PROTEINS. X2BFS7,P66182 No information pathways Rv0722 NC_002945.3 Mycobrowser_v2 CDS 817012 817452 . + 0 Mb0744 rplO 50s ribosomal protein l15 rplo Mb0744, rplO, len: 146 aa. Equivalent to Rv0723,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Probable rplO, 50S ribosomal protein L15, equivalent to MLCB2492_23|O33002 50S RIBOSOMAL PROTEIN L15 from Mycobacterium leprae (146 aa). Also highly similar to others e.g. P46787|RL15_STRCO|SCD31.46 50S RIBOSOMAL PROTEIN L15 from Streptomyces coelicolor (151 aa); P19946|RL15_BACSU 50s ribosomal protein L15 from Bacillus subtilis (146 aa),FASTA scores: opt: 419, E(): 6.5e-20, (51.0% identity in 145 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00475 Ribosomal protein L15 signature. BELONGS TO THE L15P FAMILY OF RIBOSOMAL PROTEINS. X2BFY2,Q7U1E9 No information pathways Rv0723 NC_002945.3 Mycobrowser_v2 CDS 825505 826461 . - 0 Mb0752c possible s-adenosylmethionine-dependent methyltransferase Mb0752c, -, len: 318 aa. Equivalent to Rv0731c,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c|MTCY210.45c (367 aa), FASTA score: (60.9% identity in 317 aa overlap); Rv3399, Rv1729c, etc. X2BFU1,O53795 No lipid metabolism Rv0731c NC_002945.3 Mycobrowser_v2 CDS 817485 819356 . + 0 Mb0745 sppA POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) (SIGNAL PEPTIDE PEPTIDASE) Mb0745, sppA, len: 623 aa. Equivalent to Rv0724,len: 623 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 623 aa overlap). Possible sppA,protease IV (endopeptidase IV) (EC 3.4.21.-), equivalent (but longer 23 aa) to MLCB2492_24|O33003 ENDOPEPTIDASE IV from Mycobacterium leprae (602 aa). Also similar to others e.g. NP_419743.1|NC_002696 signal peptide peptidase SppA from Caulobacter crescentus (594 aa); P08395|SPPA_ECOLI|B1766 protease IV (endopeptidase) from Escherichia coli strain K-12 (618 aa), FASTA scores: opt: 582, E(): 8.9e-27, (34.1% identity in 525 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY S49. Q7U1E8 No cell wall and cell processes Rv0724 NC_002945.3 Mycobrowser_v2 CDS 820359 821462 . - 0 Mb0747c possible s-adenosylmethionine-dependent methyltransferase Mb0747c, -, len: 367 aa. Equivalent to Rv0726c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 367 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa),FASTA scores: opt: 646, E(): 0, (38.3% identity in 329 aa overlap); Rv0731c|MTV041.05c (318 aa), Rv3399, etc. Also similar to proteins from Mycobacterium leprae and other organisms e.g. T35930 hypothetical protein SC9B5.10 from Streptomyces coelicolor (303 aa). X2BFT7,Q7U1E6 No lipid metabolism Rv0726c NC_002945.3 Mycobrowser_v2 CDS 821665 822321 . - 0 Mb0748c fucA POSSIBLE L-FUCULOSE PHOSPHATE ALDOLASE FUCA (L-FUCULOSE-1-PHOSPHATE ALDOLASE) Mb0748c, fucA, len: 218 aa. Equivalent to Rv0727c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Possible fucA,L-fuculose-1-phosphate aldolase (EC 4.1.2.17), similar to many e.g. NP_386339.1|NC_003047 PUTATIVE L-FUCULOSE PHOSPHATE ALDOLASE PROTEIN from Sinorhizobium meliloti (222 aa); P11550|FUCA_ECOLI L-FUCULOSE PHOSPHATE ALDOLASE from Escherichia strain K12 (215 aa), FASTA scores: opt: 372, E(): 4.1e-19, (34.6% identity in 185 aa overlap); etc. BELONGS TO THE ALDOLASE CLASS II FAMILY, ARAD/FUCA SUBFAMILY. COFACTOR: BINDS ONE ZINC ION PER MOLECULE. Q7U1E5 No NC_002945.3 Mycobrowser_v2 CDS 822318 823298 . - 0 Mb0749c serA2 POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA2 (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH) Mb0749c, serA2, len: 326 aa. Equivalent to Rv0728c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 326 aa overlap). Possible serA2,D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95), similar to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (344 aa), FASTA scores: opt: 594, E(): 3.1e-31, (35.9% identity in 309 aa overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1 D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis (528 aa). Q7U1E4 No NC_002945.3 Mycobrowser_v2 CDS 823329 824675 . + 0 Mb0750 xylB POSSIBLE D-XYLULOSE KINASE XYLB (XYLULOKINASE) (XYLULOSE KINASE) Mb0750, xylB, len: 448 aa. Equivalent to Rv0729,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 448 aa overlap). Possible xylB,D-xylulose-kinase (xylulokinase) (EC 2.7.1.17). C-terminus highly similar to AAD09880.1|U77912 unknown protein from Mycobacterium bovis (102 aa); and N-terminus highly similar to T45387|Z98756|MLCB2492_25 hypothetical protein from Mycobacterium leprae (110 aa), FASTA scores: opt: 427, E(): 1.1e-19, (60.9% identity in 110 aa overlap). Also similar to xylA/xylB genes from various bacterial species e.g. AAC26499.1|AF045245 D-xylulose-kinase from Klebsiella pneumoniae (487 aa); NP_418021.1|NC_000913 xylulokinase from Escherichia coli strain K12 (484 aa),FASTA scores: opt: 260, E(): 7.5e-09, (25.9% identity in 478 aa overlap); etc. Also similar to Rv3696c|glpK PROBABLE GLYCEROL KINASE (EC 2.7.1.30) from Mycobacterium tuberculosis (517 aa). BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. Q7U1E3 No intermediary metabolism and respiration Rv0729 NC_002945.3 Mycobrowser_v2 CDS 1500676 1501116 . + 0 Mb1369 mec possible hydrolase Mb1369, -, len: 146 aa. Equivalent to Rv1334, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Conserved hypothetical protein, similar to AL096852|SCE19A_13 hypothetical protein from Streptomyces coelicolor (140 aa), Fasta scores: opt: 579, E(): 0, (65.0% identity in 140 aa overlap); and Q54330|M29166 MEC+ from Streptomyces kasugaensis (115 aa), FASTA scores; E(): 7.6e-33, (56.9% identity in 109 aa overlap). X2BHM6,P64814 No intermediary metabolism and respiration Rv1334 NC_002945.3 Mycobrowser_v2 CDS 826622 827947 . + 0 Mb0753 secY PROBABLE PREPROTEIN TRANSLOCASE SECY Mb0753, secY, len: 441 aa. Equivalent to Rv0732,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable SecY,preprotein translocase (integral membrane protein),equivalent to NP_302243.1|NC_002677 SecY subunit of preprotein translocase from Mycobacterium leprae (438 aa); AAC04389.1|AF047021 preprotein translocase subunit from Mycobacterium smegmatis (438 aa); and U77912|MBU77912_1 preprotein translocase subunit from Mycobacterium bovis (441 aa), FASTA scores: opt: 2802, E(): 0, (99.8% identity in 441 aa overlap). Also highly similar to others e.g. P46785|SECY_STRCO PREPROTEIN TRANSLOCASE SECY SUBUNIT from Streptomyces coelicolor (437 aa); etc. Contains PS00755 and PS00756 protein secY signatures 1 and 2. BELONGS TO THE SECE/SEC61-ALPHA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c,SECG|Rv1440 AND SECY. X2BFT9,P0A5Z3 No cell wall and cell processes Rv0732 NC_002945.3 Mycobrowser_v2 CDS 827944 828489 . + 0 Mb0754 adk adenylate kinase adk (atp-amp transphosphorylase) Mb0754, adk, len: 181 aa. Equivalent to Rv0733,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Probable adk,adenylate kinase (ATP-AMP transphosphorylase) (EC 2.7.4.3), equivalent to Z98756|MLCB24 92_28 probable adenylate kinase from Mycobacterium leprae (181 aa), FASTA scores: opt: 978, E(): 0, (83.6% identity in 177 aa overlap); and AAF86323.1|AF271342 putative adenylate kinase from Mycobacterium marinum (124 aa) (N-terminus shorter). Also highly similar to others e.g. P43414|KAD_STRCO ADENYLATE KINASE from Streptomyces coelicolor (217 aa), FASTA score: (43.0% identity in 186 aa overlap); etc. Contains PS00113 Adenylate kinase signature. BELONGS TO THE ADENYLATE KINASE FAMILY. X2BFZ4,P69439 No intermediary metabolism and respiration Rv0733 NC_002945.3 Mycobrowser_v2 CDS 828492 829292 . + 0 Mb0755 mapA methionine aminopeptidase mapa (map) (peptidase m) (metap) Mb0755, mapA, len: 266 aa. Equivalent to Rv0734,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable mapA,methionine aminopeptidase (map) (EC 3.4.11.18), equivalent to Z98756|MLCB2492_29 probable methionine aminopeptidase from Mycobacterium leprae (266 aa), FASTA scores: opt: 1717, E(): 0, (83.4% identity in 265 aa overlap). Also highly similar to many e.g. T35553 methionine aminopeptidase from Streptomyces coelicolor (278 aa); etc. Also similar to Rv2861c|MAPB PROBABLE METHIONINE AMINOPEPTIDASE from Mycobacterium tuberculosis (285 aa). BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT. O53797 No intermediary metabolism and respiration Rv0734 NC_002945.3 Mycobrowser_v2 CDS 829365 829898 . + 0 Mb0756 sigL PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGL Mb0756, sigL, len: 177 aa. Equivalent to Rv0735,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). Probable sigL,alternative RNA polymerase sigma factor (rpoE) (see citation below), highly similar to many proteins of the extracytoplasmatic function (ECF) subfamily e.g. CAB72200.1|AL138851 putative RNA polymerase sigma factor from Streptomyces coelicolor (194 aa); Q06909|CARQ_MYXXA RNA POLYMERASE SIGMA FACTOR CARQ from Myxococcus xanthus (174 aa), FASTA scores: opt: 251, E(): 9.6e-11, (32.9% identity in 161 aa overlap); etc. Also similar to MTCI61_4, MTU87242_1, and MLU15180_30 from Mycobacterium tuberculosis. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 139-160 (Score 1134, +3.05 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. O53798 No information pathways Rv0735 NC_002945.3 Mycobrowser_v2 CDS 829962 830714 . + 0 Mb0757 rsla anti-sigma factor rsla Mb0757, -, len: 250 aa. Equivalent to Rv0736, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Probable conserved membrane protein, showing weak similarity with AL133469|SCM10_32 putative membrane protein from Streptomyces coelicolor (216 aa), FASTA scores: opt: 180,E(): 0.00018, (34.3% identity in 216 aa overlap). O53799 No information pathways Rv0736 NC_002945.3 Mycobrowser_v2 CDS 831029 831526 . + 0 Mb0758 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0758, -, len: 165 aa. Equivalent to Rv0737, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Possible transcriptional regulator, similar to others e.g. BAB69161.1|AB070937 regulator protein from Streptomyces avermitilis (169 aa); NP_419731.1|NC_002696 transcriptional regulator MarR family from Caulobacter crescentus (148 aa) (homology only at C-terminus); etc. Also shows weak similarity to AB0014|AB001488_14 hypothetical protein from Bacillus subtilis (164 aa),FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in 116 aa overlap), which is similar to slyY gene of S. typhimurium required for survival in macrophage. Contains possible helix-turn helix motif from aa 73-94 (Score 1138,+3.06 SD). O53800 No regulatory proteins Rv0737 NC_002945.3 Mycobrowser_v2 CDS 831884 832432 . + 0 Mb0759 conserved protein Mb0759, -, len: 182 aa. Equivalent to Rv0738, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Conserved hypothetical protein, showing weak similarity with hypothetical proteins from Mycobacterium tuberculosis: Rv1727|MTCY04C12.12 (189 aa); MTY13D12_7|Z80343 hypothetical protein from Mycobacterium tuberculosis (194 aa), FASTA scores: opt: 172, E(): 0.0004, (24.2% identity in 178 aa overlap); and C-terminus of Rv0576. Q7U1E2 No conserved hypotheticals Rv0738 NC_002945.3 Mycobrowser_v2 CDS 832637 833485 . + 0 Mb0760 CONSERVED HYPOTHETICAL PROTEIN Mb0760, -, len: 282 aa. Equivalent to Rv0739, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Conserved hypothetical protein, showing some similarity to Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA score: (37.6% identity in 101 aa overlap)and Rv0025 (120 aa), FASTA score: (32.4% identity in 142 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2 bp insertion (*-cg) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa). Q7U1E1 No conserved hypotheticals Rv0739 NC_002945.3 Mycobrowser_v2 CDS 833600 834127 . + 0 Mb0761 CONSERVED HYPOTHETICAL PROTEIN Mb0761, -, len: 175 aa. Equivalent to Rv0740, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Conserved hypothetical protein; C-terminus (possibly part of truncated IS1557) shows nearly perfect identity to Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% identity in 81 aa overlap). Also shows weak similarity to MTV007_5 hypothetical protein from Mycobacterium tuberculosis (313 aa), FASTA score: (34.5% identity in 110 aa overlap); and MLCL536_27 hypothetical protein from Mycobacterium leprae (315 aa), FASTA score: (34.5% identity in 84 aa overlap). Q7U1E0 No conserved hypotheticals Rv0740 NC_002945.3 Mycobrowser_v2 CDS 834358 834672 . + 0 Mb0762 probable transposase (fragment) Mb0762, -, len: 104 aa. Equivalent to Rv0741, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable truncated transposase for IS1557, showing similarity to transposases and IS elements e.g. U63997|EFU63997_1 insertion sequence from Enterococcus faecium (424 aa), FASTA score: (31.0% identity in 87 aa overlap). Very high similarity with the C-terminal part of Z73419|MTCY373_3 2 IS1557 from Mycobacterium tuberculosis (444 aa), FASTA score: (86.5% identity in 104 aa overlap). Q7U1D9 No insertion seqs and phages Rv0741 NC_002945.3 Mycobrowser_v2 CDS 834814 835332 . + 0 Mb0763 PE_PGRS8 pe-pgrs family protein pe_pgrs8 Mb0763, PE_PGRS8, len: 172 aa. Equivalent to Rv0742, len: 172 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 172 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many M. tuberculosis PGRS-type proteins e.g. Z78020|MTCY1A11_25 (498 aa), FASTA scores: opt: 766, E(): 6.1e-25, (73.6% identity in 178 aa overlap). Similarity suggests ORF starts with ATA start codon. Q7U1D8 No PE/PPE Rv0742 NC_002945.3 Mycobrowser_v2 CDS 835710 836267 . - 0 Mb0764c HYPOTHETICAL PROTEIN Mb0764c, -, len: 185 aa. Equivalent to Rv0743c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Hypothetical unknown protein. Q7U1D7 No conserved hypotheticals Rv0743c NC_002945.3 Mycobrowser_v2 CDS 836264 836770 . - 0 Mb0765c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0765c, -, len: 168 aa. Equivalent to Rv0744c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Possible transcriptional regulator, showing weak similarity with O86661|SC4A2.05 PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (436 aa), FASTA scores: opt: 117,E(): 0.88, (37.25% identity in 94 aa overlap); and some putative excisionases or transposases. Also weakly similar to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (114 aa); and Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (148 aa). Equivalent to AAK45006 from Mycobacterium tuberculosis strain CDC1551 (179 aa) but shorter 11 aa. Contains probable helix-turn helix motif from aa 5-26 (Score 1350, +3.78 SD). Q7U1D6 No regulatory proteins Rv0744c NC_002945.3 Mycobrowser_v2 CDS 836978 837505 . + 0 Mb0766 CONSERVED HYPOTHETICAL PROTEIN Mb0766, -, len: 175 aa. Equivalent to Rv0745, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Conserved hypothetical protein; shows high similarity to a 50 aa region of Rv3649|Z95436|MTY15C10_3 CONSERVED HYPOTHETICAL PROTEIN, similar to ATP-dependent helicases, from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 225, E(): 7e-06, (70.0% identity in 50 aa overlap). Q7U1D5 No conserved hypotheticals Rv0745 NC_002945.3 Mycobrowser_v2 CDS 837525 839918 . + 0 Mb0767 PE_PGRS9 pe-pgrs family protein pe_pgrs9 Mb0767, PE_PGRS9, len: 797 aa. Equivalent to Rv0746, len: 783 aa, from Mycobacterium tuberculosis strain H37Rv, (89.7% identity in 829 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2429, E(): 0,(56.9% identity in 873 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. AL0212|MTV008_46 FASTA score: (48.8% identity in 887 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Q7U1D4 No PE/PPE Rv0746 NC_002945.3 Mycobrowser_v2 CDS 840317 843046 . + 0 Mb0768 PE_PGRS10 pe-pgrs family protein pe_pgrs10 Mb0768, PE_PGRS10, len: 909 aa. Equivalent to Rv0747, len: 801 aa, from Mycobacterium tuberculosis strain H37Rv, (86.6% identity in 912 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2772, E(): 0,(60.9% identity in 941 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. Z95844|MTCY493_2 FASTA score: (50.2% identity in 815 aa overlap). Contains PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (cggcaacgg-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa versus 801 aa). Q7U1D3 No NC_002945.3 Mycobrowser_v2 CDS 844537 845421 . - 0 Mb0773c mmsB PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH) Mb0773c, mmsB, len: 294 aa. Equivalent to Rv0751c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Probable mmsB,3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31), highly similar to others e.g. NP_102847.1|NC_002678 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti (294 aa); NP_420167.1|NC_002696 3-hydroxyisobutyrate dehydrogenase from Caulobacter crescentus (298 aa); A32867 3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus (346 aa); etc. Also similar to methylmalonate semialdehyde dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate semialdehyde dehydrogenase from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 786, E(): 0, (45.8% identity in 297 aa overlap). Also similar to 6-phosphogluconate dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. Contains PS00895 3-hydroxyisobutyrate dehydrogenase signature. BELONGS TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY. X2BFW4,P63936 No NC_002945.3 Mycobrowser_v2 CDS 845432 846604 . - 0 Mb0774c fadE9 PROBABLE ACYL-COA DEHYDROGENASE FADE9 Mb0774c, fadE9, len: 390 aa. Equivalent to Rv0752c,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 390 aa overlap). Probable fadE9,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. NP_437985.1|NC_003078 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (380 aa); Z99123|BSUB0020_14 from Bacillus subtilis (379 aa),FASTA scores: opt: 853, E(): 0, (39.8% identity in 384 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, and PS00073 Acyl-Co Adehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7U1C8 No NC_002945.3 Mycobrowser_v2 CDS 871173 871952 . - 0 Mb0799c CONSERVED HYPOTHETICAL PROTEIN Mb0799c, -, len: 259 aa. Equivalent to Rv0776c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Conserved hypothetical protein, similar (except first 50 aa) to P72737|D90900_57 hypothetical protein from Synechocystis sp. strain PCC 6803 (261 aa), FASTA scores: opt: 337, E(): 1.7e-15, (30.5% identity in 266 aa overlap). Q7U1A9 No conserved hypotheticals Rv0776c NC_002945.3 Mycobrowser_v2 CDS 846611 848143 . - 0 Mb0775c mmsA PROBABLE METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE MMSA (METHYLMALONIC ACID SEMIALDEHYDE DEHYDROGENASE) (MMSDH) Mb0775c, mmsA, len: 510 aa. Equivalent to Rv0753c,len: 510 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 510 aa overlap). Probable mmsA,methylmalonic acid semialdehyde dehydrogenase (EC 1.2.1.27), highly similar to others e.g. NP_420115.1|NC_002696 putative methylmalonate-semialdehyde dehydrogenase from Caulobacter crescentus (499 aa); L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor (500 aa), FASTA score: (51.6% identity in 498 aa overlap); M84911|PSEMMSRAB_2|NP_252260.1|NC_002516 methylmalonate-semialdehyde dehydrogenase from Pseudomonas aeruginosa (497 aa), FASTA scores: opt: 1127, E(): 0,(47.9% identity in 507 aa overlap); etc. Note that also highly similar to malonic semialdehyde oxidative decarboxylases e.g. NP_104968.1|NC_002678 malonic semialdehyde oxidative decarboxylase from Mesorhizobium loti (498 aa); NP_384832.1|NC_003047 PUTATIVE MALONIC SEMIALDEHYDE OXIDATIVE DECARBOXYLASE PROTEIN from Sinorhizobium meliloti (498 aa); etc. Contains PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Q7U1C7 No NC_002945.3 Mycobrowser_v2 CDS 866329 866763 . + 0 Mb0794 POSSIBLE 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) Mb0794, -, len: 144 aa. Equivalent to Rv0771, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible 4-carboxymuconolactone decarboxylase (EC 4.1.1.44),showing similarity with other carboxymuconolactone decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein from Pseudomonas putida (130 aa); P20370|DC4C_ACICA 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) from Acinetobacter sp. ADP1 (134 aa), FASTA scores: opt: 174,E(): 0.00075, (31.4% identity in 121 aa overlap); C-terminus of NP_421214.1|NC_002696 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Caulobacter crescentus (393 aa); C-terminus of T47115 probable 4-carboxymuconolactone decarboxylase / 3-oxoadipate enol-lactone hydrolase from Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative gamma carboxymuconolactone decarboxylase from Yersinia pestis (131 aa); etc. Q7U1B3 No intermediary metabolism and respiration Rv0771 NC_002945.3 Mycobrowser_v2 CDS 854586 856043 . + 0 Mb0781 phoR POSSIBLE TWO COMPONENT SYSTEM RESPONSE SENSOR KINASE MEMBRANE ASSOCIATED PHOR Mb0781, phoR, len: 485 aa. Equivalent to Rv0758,len: 485 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 485 aa overlap). Possible phoR, two component system response phosphate sensor kinase membrane-associated (EC 2.7.-.-), highly similar to various sensor kinases e.g. CAC32361.1|AL583945 putative two component system histidine kinase from Streptomyces coelicolor (524 aa); NP_349365.1|NC_003030 Membrane-associated sensory histidine kinase with HAMP domain from Clostridium acetobutylicum (482 aa); and similar to phoP proteins e.g. NP_372216.1|NC_002758 alkaline phosphatase synthesis sensor protein from Staphylococcus aureus (554 aa); P23545|PHOR_BACSU alkaline phosphatase synthesis sensor from Bacillus subtilis (579 aa), FASTA scores: opt: 515, E(): 1.9e-25, (40.0% identity in 230 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. MTCY20G9.16 FASTA scores: (34.5% identity in 264 aa overlap), MTU88959_2 (509 aa),MTCY10G2_17, etc. Q7U1C1 No regulatory proteins Rv0758 NC_002945.3 Mycobrowser_v2 CDS 848349 850103 . + 0 Mb0776 PE_PGRS11 pe-pgrs family protein pe_pgrs11 Mb0776, PE_PGRS11, len: 584 aa. Equivalent to Rv0754, len: 584 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 584 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. AL0212|MTV008_46 from Mycobacterium tuberculosis (1660 aa), FASTA score: (48.7% identity in 345 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa),FASTA score: (41.6% identity in 442 aa overlap); etc. Q7U1C6 No NC_002945.3 Mycobrowser_v2 CDS 850293 852230 . - 0 Mb0777c PPE12 ppe family protein ppe12 Mb0777c, PPE12, len: 645 aa. Equivalent to Rv0755c,len: 645 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 645 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to others e.g. Z82098|MTCY3C7_23 from Mycobacterium tuberculosis (582 aa), FASTA scores: (56.1% identity in 636 aa overlap); Z92774|MTCY6G11_5 from Mycobacterium tuberculosis (552 aa), FASTA scores: (55.8% identity in 590 aa overlap); etc. Q7U1C5 No NC_002945.3 Mycobrowser_v2 CDS 852532 852717 . - 0 Mb0778c PUTATIVE TRANSPOSASE (FRAGMENT) Mb0778c, -, len: 61 aa. Equivalent to Rv0755A, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 61 aa overlap). Putative transposase (possibly gene fragment), similar to C-terminal part of Q9EZM2|ISMav2|AF286339_1 putative transposase from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 284, E(): 5e-13, (83.02% identity in 53 aa overlap); and to SCJ11.25c|Q9RI80 possible noncomposite transposon transposase from Streptomyces coelicolor (283 aa). Q7U1C4 No insertion seqs and phages Rv0755A NC_002945.3 Mycobrowser_v2 CDS 852931 853656 . - 0 Mb0779c unknown protein Mb0779c, -, len: 241 aa. Equivalent to Rv0756c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Hypothetical unknown protein. Q7U1C3 No conserved hypotheticals Rv0756c NC_002945.3 Mycobrowser_v2 CDS 1501138 1501419 . + 0 Mb1370 cyso sulfur carrier protein cyso Mb1370, -, len: 93 aa. Equivalent to Rv1335, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 93 aa overlap). 9.5 kDa culture filtrate antigen cfp10A (see citation below). Similar to hypothetical proteins from other organisms e.g. P74060|D90911 Synechocystis (109 aa), FASTA scores: E(): 2.3e-20, (49.5% identity in 93 aa overlap). X2BHE1,P0A647 No intermediary metabolism and respiration Rv1335 NC_002945.3 Mycobrowser_v2 CDS 853798 854541 . + 0 Mb0780 phoP POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP Mb0780, phoP, len: 247 aa. Equivalent to Rv0757,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Possible phoP, two component system response phosphate regulon transcriptional regulator, highly similar to various transcriptional regulators e.g. CAC32360.1|AL583945 putative two component system response regulator from Streptomyces coelicolor (271 aa); T45446 probable two-component response regulator from Mycobacterium leprae (253 aa); and similar to phoP proteins e.g. P13792|PHOP_BACSU alkaline phosphatase synthesis transcription regulatory protein from Bacillus subtilis (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, (41.0% identity in 234 aa overlap); etc. Also highly similar to Rv3765c from Mycobacterium tuberculosis (234 aa), Rv1033c (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa), FASTA score: (45.4% identity in 229 aa overlap); MTCY10G2_16 and MTU88959_1. Q7U1C2 No regulatory proteins Rv0757 NC_002945.3 Mycobrowser_v2 CDS 856015 856347 . - 0 Mb0782c CONSERVED HYPOTHETICAL PROTEIN Mb0782c, -, len: 110 aa. Equivalent to Rv0759c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Conserved hypothetical protein, highly similar (but shorter 45 aa in N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A HYPOTHETICAL HIT-LIKE PROTEIN from Mycobacterium leprae (155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity in 150 aa overlap). Also highly similar (but N-terminus always shorter) to HIT-like proteins and protein kinase inhibitors e.g. AAF72728.1|AF265258_1|AF265258 HIT-like protein from Rhodococcus sp. (141 aa); NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI) from Borrelia burgdorferi (149 aa) ; P94252|YHIT_BORBU|BB0379 HYPOTHETICAL HIT-LIKE PROTEIN from Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689 HIT (histidine triad) family protein from Thermoplasma volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa),FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity in 111 aa overlap); etc. Also shows similarity with Rv2613c|MTCY01A10.20A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20 HYPOTHETICAL HIT-LIKE PROTEIN (144 aa). X2BFV7,P0A5B6 No conserved hypotheticals Rv0759c NC_002945.3 Mycobrowser_v2 CDS 856456 856875 . - 0 Mb0783c conserved protein Mb0783c, -, len: 139 aa. Equivalent to Rv0760c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, similar to N-terminal part of Rv2042c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (265 aa), FASTA scores: opt: 150, E(): 4.1e-05, (28.7% identity in 136 aa overlap). Q7U1C0 No conserved hypotheticals Rv0760c NC_002945.3 Mycobrowser_v2 CDS 856888 858015 . - 0 Mb0784c adhB possible zinc-containing alcohol dehydrogenase nad dependent adhb Mb0784c, adhB, len: 375 aa. Equivalent to Rv0761c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Possible adhB,zinc-containing alcohol dehydrogenase NAD-dependant (EC 1.1.1.1), similar to others e.g. AAC15839.1|AF060871_4 hypothetical alcohol dehydrogenase from Rhodococcus rhodochrous (370 aa), FASTA scores: opt: 1234, E(): 0,(46.8% identity in 370 aa overlap); P80468|ADH2_STRCA ALCOHOL DEHYDROGENASE II from Struthio camelus (Ostrich) (379 aa); Q03505|ADH1_RABIT alcohol dehydrogenase alpha chain from Oryctolagus cuniculus (Rabbit) (374 aa), FASTA scores: opt: 872, E(): 0, (39.1% identity in 379 aa overlap); etc. Also similar to adhD alcohol dehydrogenase from Mycobacterium tuberculosis (368 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY. X2BG32,Q7U1B9 No NC_002945.3 Mycobrowser_v2 CDS 858114 858659 . - 0 Mb0785c CONSERVED HYPOTHETICAL PROTEIN Mb0785c, -, len: 181 aa. Equivalent to Rv0762c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Conserved hypothetical protein, showing weak similarity to D90907_77|P73575 HYPOTHETICAL 31.3KD PROTEIN from Synechocystis sp, FASTA scores: E(): 0.0012, (30.4% identity in 92 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1B8 No conserved hypotheticals Rv0762c NC_002945.3 Mycobrowser_v2 CDS 858662 858868 . - 0 Mb0786c POSSIBLE FERREDOXIN Mb0786c, -, len: 68 aa. Equivalent to Rv0763c, len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Possible ferredoxin,similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c PROBABLE CYTOCHROME P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 137, E(): 0.00013, (36.4% identity in 66 aa overlap). Also similar to putative ferredoxins Rv3503c and Rv1786 from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY. Q7U1B7 No intermediary metabolism and respiration Rv0763c NC_002945.3 Mycobrowser_v2 CDS 910860 911672 . - 0 Mb0840c PROBABLE CONSERVED EXPORTED PROTEIN Mb0840c, -, len: 270 aa. Equivalent to Rv0817c,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Probable conserved exported protein, with N-terminal signal sequence,equivalent (but shorter 13 aa) to U15182|MLU15182_22|U2266M probable exported protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1287,E(): 0, (73.0% identity in 270 aa overlap). Q7U175 No cell wall and cell processes Rv0817c NC_002945.3 Mycobrowser_v2 CDS 858871 860226 . - 0 Mb0787c cyp51 CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM) Mb0787c, cyp51, len: 451 aa. Equivalent to Rv0764c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). cyp51, cytochrome P450 51 (sterol 14-alpha demethylase) (EC 1.14.14.-),similar to others e.g. Q16850|CP51_HUMAN CYTOCHROME P450 51 (CYPL1) (P450L1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Homo sapiens (509 aa), FASTA scores: opt: 848, E(): 0, (33.9% identity in 439 aa overlap); NP_172633.1|NC_003070 putative obtusifoliol 14-alpha demethylase from Arabidopsis thaliana (488 aa); P93596|CP51_WHEAT CYTOCHROME P450 51 (CYPL1) (P450-L1A1) (OBTUSIFOLIOL 14-ALPHA DEMETHYLASE) from Triticum aestivum (453 aa); etc. Also similar to many other Mycobacterium tuberculosis cytochromes P450 e.g. Rv1394c, FASTA score: (22.5% identity in 444 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BFW1,P0A513 No NC_002945.3 Mycobrowser_v2 CDS 860226 861053 . - 0 Mb0788c PROBABLE OXIDOREDUCTASE Mb0788c, -, len: 275 aa. Equivalent to Rv0765c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar others e.g. P39071|DHBA_BACSU 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Bacillus subtilis (261 aa), FASTA scores: opt: 385, E(): 1.8e-17, (30.6% identity in 252 aa overlap); AAF81239.1|AF263012 putative beta-ketoacyl reductase from Streptomyces griseus (274 aa); NP_436514.1|NC_003037 putative oxidoreductase from Sinorhizobium meliloti (240 aa); etc. Also similar to several other oxidoreductases from Mycobacterium tuberculosis e.g. Rv1544|MTCY48.21, FASTA score: (32.6% identity in 267 aa overlap); etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. Q7U1B6 No intermediary metabolism and respiration Rv0765c NC_002945.3 Mycobrowser_v2 CDS 861053 862261 . - 0 Mb0789c cyp123 PROBABLE CYTOCHROME P450 123 CYP123 Mb0789c, cyp123, len: 402 aa. Equivalent to Rv0766c, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 402 aa overlap). Probable cyp123, cytochrome P-450 (EC 1.14.-.-), similar to others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 from Saccharopolyspora erythraea (405 aa), FASTA scores: opt: 770, E(): 0, (36.9% identity in 406 aa overlap); T36526 probable cytochrome P450 hydroxylase from Streptomyces coelicolor (411 aa); P27632|CPXM_BACSU CYTOCHROME P450 109 from Bacillus subtilis (405 aa); etc. Also similar to several other cytochromes P-450 from Mycobacterium tuberculosis e.g. Rv1256c|MTCY50.26 (405 aa), FASTA score: (35.2% identity in 389 aa overlap); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BG36,P63708 No intermediary metabolism and respiration Rv0766c NC_002945.3 Mycobrowser_v2 CDS 862258 862899 . - 0 Mb0790c CONSERVED HYPOTHETICAL PROTEIN Mb0790c, -, len: 213 aa. Equivalent to Rv0767c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, showing weak similarity with AL133220|SCC75A_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (215 aa), FASTA scores: opt: 152, E(): 0.0048,(28.4% identity in 204 aa overlap). X2BG56,P67433 No conserved hypotheticals Rv0767c NC_002945.3 Mycobrowser_v2 CDS 863101 864570 . + 0 Mb0791 aldA probable aldehyde dehydrogenase nad dependent alda (aldehyde dehydrogenase [nad+]) Mb0791, aldA, len: 489 aa. Equivalent to Rv0768,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 489 aa overlap). Probable aldA,NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid dehydrogenase from Rhodococcus ruber (474 aa); NP_285450.1|NC_001264 aldehyde dehydrogenase from Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570 NADP-dependent aldehyde dehydrogenase from Bacillus halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde dehydrogenase precursor from Atriplex hortensis (Mountain spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6% identity in 486 aa overlap); etc. Also highly similar to Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium tuberculosis (487 aa). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Q7TTS0 No intermediary metabolism and respiration Rv0768 NC_002945.3 Mycobrowser_v2 CDS 864601 865347 . + 0 Mb0792 PROBABLE DEHYDROGENASE/REDUCTASE Mb0792, -, len: 248 aa. Equivalent to Rv0769, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 248 aa overlap). Probable dehydrogenase/reductase (EC 1.-.-.-), similar to others,especially short-chain type dehydrogenases/reductases and 3-oxoacyl-(acyl-carrier protein) reductases e.g. NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa); NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein) reductase from Bacillus halodurans (246 aa); P28643|FABG_CUPLA 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Cuphea lanceolata (320 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 536,E(): 6.5e-27, (37.7% identity in 247 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. MTCY02B10.14, FASTA score: (33.7% identity in 249 aa overlap); etc. Q7U1B5 No intermediary metabolism and respiration Rv0769 NC_002945.3 Mycobrowser_v2 CDS 865445 866332 . + 0 Mb0793 PROBABLE DEHYDROGENASE/REDUCTASE Mb0793, -, len: 295 aa. Equivalent to Rv0770, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable dehydrogenase/reductase, 3-hydroxyisobutyrate dehydrogenase family (EC 1.1.1.-), possibly 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) or 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60), similar to others e.g. P23523|GARR_ECOLI 2-HYDROXY-3-OXOPROPIONATE REDUCTASE (TARTRONATE SEMIALDEHYDE REDUCTASE) (TSAR) from Escherichia coli strain K12 (294 aa), FASTA scores: opt: 469, E(): 6.7e-22, (34.4% identity in 282 aa overlap); P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase (HIBADH) from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 439, E(): 4.3e-20, (34.9% identity in 269 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. SEEMS TO BELONG TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY. Q7U1B4 No intermediary metabolism and respiration Rv0770 NC_002945.3 Mycobrowser_v2 CDS 866775 868043 . + 0 Mb0795 purD PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) Mb0795, purD, len: 422 aa. Equivalent to Rv0772,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Probable purD,phosphoribosylamine--glycine ligase (EC 6.3.4.13),equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08 PHOSPHORIBOSYLAMINE--GLYCINE LIGASE from Mycobacterium leprae (422 aa), FASTA scores: opt: 2272, E(): 0, (81.8% identity in 422 aa overlap). Also highly similar to others e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine ligase from Streptomyces coelicolor (416 aa); P1564|PUR2_ECOLI phosphoribosylamine--glycine ligase from Escherichia coli (429 aa), FASTA scores: opt: 1039, E(): 0, (42.7% identity in 431 aa overlap); etc. BELONGS TO THE GARS FAMILY. X2BG60,P65894 No intermediary metabolism and respiration Rv0772 NC_002945.3 Mycobrowser_v2 CDS 868040 869578 . - 0 Mb0796c ggtA PROBABLE BIFUNCTIONAL ACYLASE GGTA: CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE) + GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT) Mb0796c, ggtA, len: 512 aa. Equivalent to Rv0773c,len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Probable ggtA,bifunctional acylase including cephalosporin acylase (EC 3.5.1.-), and gamma-glutamyl transpeptidase (EC 2.3.2.2); highly similar to others e.g. NP_295247.1|NC_001263 cephalosporin acylase from Deinococcus radiodurans (535 aa); NP_248854.1|NC_002516 probable gamma-glutamyltranspeptidase from Pseudomonas aeruginosa (538 aa); P15557|PAC1_PSES3 ACYLASE ACY 1 [INCLUDES: CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE); GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)] from Pseudomonas sp. strain SE83 (558 aa), FASTA scores: opt: 784, E(): 0,(34.2% identity in 526 aa overlap); NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein similar to gamma-glutamyltransferase from Bacillus subtilis (525 aa), FASTA scores: opt: 1169, E(): 0, (40.1% identity in 516 aa overlap); etc. Also similar to Rv2394|ggtB from Mycobacterium tuberculosis. Member of GL-7ACA ACYLASES AND TO GGT group. Q7U1B2 No NC_002945.3 Mycobrowser_v2 CDS 869629 870540 . - 0 Mb0797c PROBABLE CONSERVED EXPORTED PROTEIN Mb0797c, -, len: 303 aa. Equivalent to Rv0774c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 303 aa overlap). Possible conserved exported protein with hydrophobic region near N-terminus,highly similar, except in N-terminus, to Rv0519c|Z97831|MTY20G10.09c|O33364 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (300 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature, and PS00120 Lipases, serine active site. So could be a lipase (EC 3.1.-.-). Q7U1B1 No cell wall and cell processes Rv0774c NC_002945.3 Mycobrowser_v2 CDS 870596 871219 . + 0 Mb0798 CONSERVED HYPOTHETICAL PROTEIN Mb0798, -, len: 207 aa. Equivalent to Rv0775, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins e.g. ECAE000186_11|MG1655 HYPOTHETICAL PROTEIN from Escherichia coli strain K-12 (178 aa), FASTA scores: E(): 6.4e-05, (27.2% identity in 147 aa overlap); P41037|BIH_ECOLI hypothetical transcriptional regulator from Escherichia coli (103 aa), FASTA scores: opt: 138,E(): 0.003, (30.9% identity in 97 aa overlap); etc. Q7U1B0 No conserved hypotheticals Rv0775 NC_002945.3 Mycobrowser_v2 CDS 892302 893099 . - 0 Mb0821c cfp29 29 KDa ANTIGEN CFP29 Mb0821c, cfp29, len: 265 aa. Equivalent to Rv0798c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). cfp29, 29 kDa antigen (see citations below). Highly similar to Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from Brevibacterium linens (266 aa), FASTA scores: (58.5% identity in 265 aa overlap). Also shows similarity with NP_228594.1|NC_000853 bacteriocin from Thermotoga maritima (262 aa). Q7U190 No NC_002945.3 Mycobrowser_v2 CDS 872197 873615 . + 0 Mb0800 purB PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) (ASL) (ASASE) Mb0800, purB, len: 472 aa. Equivalent to Rv0777,len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable purB,adenylosuccinate lyase (EC 4.3.2.2), equivalent (but shorter 15 aa) to MLCB5.13|Z95151|g2076607|PURB ADENYLOSUCCINATE LYASE from Mycobacterium leprae (487 aa),FASTA scores: opt: 2640, E(): 0, (86.7% identity in 472 aa overlap). More similar to eukaryotic adenylosuccinate lyases than to prokaryotic adenylosuccinate lyases e.g. P54822|PUR8_MOUSE ADENYLOSUCCINATE LYASE from Mus musculus (484 aa), FASTA scores: opt: 762, E(): 0, (32.4% identity in 445 aa overlap); CAB99134.1|AL390188 putative adenylosuccino lyase (fragment) from Streptomyces coelicolor (362 aa); etc. Contains PS00163 Fumarate lyases signature. BELONGS TO THE LYASE 1 FAMILY, ADENYLOSSUCINATE LYASE SUBFAMILY. Q7U1A8 No intermediary metabolism and respiration Rv0777 NC_002945.3 Mycobrowser_v2 CDS 882124 883230 . + 0 Mb0808 CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb0808, -, len: 368 aa. Equivalent to 3' end of Rv0785, len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 368 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 from Deinococcus radiodurans (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FASTA scores: opt: 169, E(): 0.0014,(23.8% identity in 542 aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% identity in 587 aa overlap). And shows similarity with other dehydrogenases. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808. Q7U1A2 No NC_002945.3 Mycobrowser_v2 CDS 873620 874864 . + 0 Mb0801 cyp126 POSSIBLE CYTOCHROME P450 126 CYP126 Mb0801, cyp126, len: 414 aa. Equivalent to Rv0778,len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Possible cyp126,cytochrome P-450 (EC 1.14.-.-), similar to other cytochromes and related proteins e.g. AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1 cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28) (lin C) from Pseudomonas incognita (406 aa), FASTA scores: opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. X2BG53,P63712 No NC_002945.3 Mycobrowser_v2 CDS 874861 875481 . - 0 Mb0802c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0802c, -, len: 206 aa. Equivalent to Rv0779c,len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Possible conserved transmembrane protein, equivalent to Z95151|MLCB5_14 O05747 conserved hypothetical protein from Mycobacterium leprae (206 aa), FASTA scores: opt: 902, E(): 0, (67.2% identity in 204 aa overlap). Q7U1A7 No cell wall and cell processes Rv0779c NC_002945.3 Mycobrowser_v2 CDS 888027 888836 . - 0 Mb0816c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0816c, -, len: 269 aa. Equivalent to Rv0792c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 269 aa overlap). Probable transcriptional regulator, GntR-family, similar to many others of GntR family e.g. BSUB0018_189|Z99121 from Bacillus subtilis (243 aa), FASTA scores: opt: 367, E(): 1.5e-17, (32.1% identity in 246 aa overlap); P31453|YIDP_ECOLI from Escherichia coli (238 aa), FASTA scores: opt: 236, E(): 8.8e-09, (26.4% identity in 235 aa overlap); etc. Q7U195 No regulatory proteins Rv0792c NC_002945.3 Mycobrowser_v2 CDS 875532 876425 . + 0 Mb0803 purC PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE PURC (SAICAR SYNTHETASE) Mb0803, purC, len: 297 aa. Equivalent to Rv0780,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 297 aa overlap). purC,phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (see citations below), equivalent to MTU34957_1|PURC phosphoribosylaminoimidazole-succinocarboxamide synthase from Mycobacterium leprae (297 aa), FASTA scores: opt: 1986, E(): 0, (99.3% identity in 297 aa overlap). Also similar to others e.g. CAB56351.1|AL118514 phosphoribosylaminoimidazole-succinocarboxamide synthase from Streptomyces coelicolor (299 aa); etc. Contains PS01058 SAICAR synthetase signature 2. BELONGS TO THE SAICAR SYNTHETASE FAMILY. X2BG03,P0A5T5 No intermediary metabolism and respiration Rv0780 NC_002945.3 Mycobrowser_v2 CDS 876422 878581 . + 0 Mb0804 ptrB probable protease ii ptrbb [second part] (oligopeptidase b) Mb0804, ptrB, len: 719 aa. Equivalent to Rv0781 and Rv0782, len: 236 aa and 552 aa, from Mycobacterium tuberculosis strain H37Rv, (97.6% identity in 206 aa overlap and 100.0% identity in 517 aa overlap). Probable ptrB, protease II (EC 3.4.21.83), equivalent to NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to C-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa),FASTA scores: opt: 204, E(): 7.4e-07, (29.6% identity in 230 aa overlap); etc. Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa), FASTA scores: opt: 1251, E(): 0, (42.7% identity in 489 aa overlap); etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II, but we can find no error in the cosmid sequence to account for this. BELONGS TO PEPTIDASE FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. Note that previously known as ptrBb. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes,ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis, a 2 bp insertion (*-gc) leads to a single product. Q7U1A6 No intermediary metabolism and respiration Rv0781 NC_002945.3 Mycobrowser_v2 CDS 883265 883903 . - 0 Mb0809c conserved protein Mb0809c, -, len: 212 aa, equivalent to hypothetical protein MT0810 from Mycobacterium tuberculosis strain CDC1551, len: 212 aa (100% identity with 212 aa overlap). Mb0809c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BG57 No NC_002945.3 Mycobrowser_v2 CDS 884950 885624 . + 0 Mb0812 purQ PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I PURG (FGAM SYNTHASE I) Mb0812, purQ, len: 224 aa. Equivalent to Rv0788,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable purQ,phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3),equivalent to MLCB5_24|Z95151|O05756|PURQ PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from Mycobacterium leprae (224 aa), FASTA scores: opt: 1341,E(): 0, (88.7% identity in 222 aa overlap). Also highly similar to others e.g. P12041|PURQ_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from Bacillus subtilis (227 aa), FASTA scores: opt: 691, E(): 8.6e-39,(47.7% identity in 214 aa overlap); etc. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO TYPE-1 GLUTAMINE AMIDOTRANSFERASES. X2BFY1,P65903 No intermediary metabolism and respiration Rv0788 NC_002945.3 Mycobrowser_v2 tRNA 924940 925013 . + 0 aspT aspT tRNA-Asp aspT, len: 74 nt. Equivalent to aspT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Asp, anticodon gtc. No NC_002945.3 Mycobrowser_v2 tRNA 925043 925116 . + 0 pheU pheU tRNA-Phe pheU, len: 74 nt. Equivalent to pheU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Phe, anticodon gaa. No NC_002945.3 Mycobrowser_v2 CDS 879009 880631 . - 0 Mb0805c emrB POSSIBLE MULTIDRUG RESISTANCE INTEGRAL MEMBRANE EFFLUX PROTEIN EMRB Mb0805c, emrB, len: 540 aa. Equivalent to Rv0783c,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). Possible emrB,integral membrane drug efflux protein, member of major facilitator superfamily (MFS), equivalent to AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from Mycobacterium avium (538 aa). Also similar to other membrane proteins e.g. CAB61606.1|AL133210 putative export protein from Streptomyces coelicolor (496 aa); NP_108371.1|NC_002678 efflux pump protein FarB from Mesorhizobium loti (511 aa); P44927|EMRB_HAEINHI0897| multidrug resistance protein b homologue from Haemophilus influenzae (510 aa), FASTA scores: opt: 706, E(): 1.3e-36,(30.4% identity in 408 aa overlap); etc. Also similar to Rv2333c|MTCY3G12.01 from Mycobacterium tuberculosis (537 aa), FASTA score: (28.2% identity in 408 aa overlap); and Rv1410c|MTCY21B4.27c from Mycobacterium tuberculosis (518 aa), FASTA score: (26.8% identity in 496 aa overlap). BELONGS TO THE MAJOR FACILITATOR FAMILY; ALSO KNOWN AS THE DRUG RESISTANCE TRANSLOCASE FAMILY. Q7U1A5 No NC_002945.3 Mycobrowser_v2 CDS 880829 881515 . + 0 Mb0806 CONSERVED HYPOTHETICAL PROTEIN Mb0806, -, len: 228 aa. Equivalent to Rv0784, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Conserved hypothetical protein, with some similarity to MLCB5_20|O05752 hypothetical protein from Mycobacterium leprae (193 aa), FASTA scores: opt: 141, E(): 0.0022,(36.0% identity in 114 aa overlap). Also similar to N-terminus of NP_253002.1|NC_002516 conserved hypothetical protein from Pseudomonas aeruginosa (253 aa). Q7U1A4 No conserved hypotheticals Rv0784 NC_002945.3 Mycobrowser_v2 CDS 881531 882106 . + 0 Mb0807 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb0807, -, len: 191 aa. Equivalent to 5' end of Rv0785, len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, (97.1% identity in 140 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 from Deinococcus radiodurans (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FASTA scores: opt: 169, E(): 0.0014,(23.8% identity in 542 aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% identity in 587 aa overlap). And shows similarity with other dehydrogenases. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808. Q7U1A3 No NC_002945.3 Mycobrowser_v2 CDS 884714 884953 . + 0 Mb0811 conserved protein Mb0811, -, len: 79 aa. Equivalent to Rv0787A, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, equivalent to MLCB5.24 HYPOTHETICAL PROTEIN from Mycobacterium leprae (79 aa), FASTA scores: opt: 434,(84.8% identity in 79 aa overlap). Also similar to P12049|YEXA_BACSU HYPOTHETICAL 9.7 KD PROTEIN from Bacillus subtilis (84 aa), FASTA scores: opt: 172, E(): 4e-06, (44.4% identity in 72 aa overlap). BELONGS TO THE UPF0062 FAMILY. Q7U199 No conserved hypotheticals Rv0787A NC_002945.3 Mycobrowser_v2 CDS 886987 888030 . - 0 Mb0815c conserved protein Mb0815c, -, len: 347 aa. Equivalent to Rv0791c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Conserved hypothetical protein, similar (except in N-terminus) to others e.g. CAC44585.1|AL596162 conserved hypothetical protein from Streptomyces coelicolor (307 aa); NP_252643.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (364 aa); etc. Also some similarity with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); etc. And also similar in part to other proteins from Mycobacterium tuberculosis e.g. Rv1855c|MTCY359.18|Z83859 (307 aa), FASTA scores: opt: 366, E(): 4e-16, (35.0% identity in 226 aa overlap); Rv3079c|MTCY22D7.02|Z83866 CONSERVED HYPOTHETICAL PROTEIN (275 aa), FASTA scores: opt: 342, E(): 1.2e-14, (31.6% identity in 234 aa overlap); Rv0044c POSSIBLE OXIDOREDUCTASE (264 aa). Q7U196 No conserved hypotheticals Rv0791c NC_002945.3 Mycobrowser_v2 CDS 888909 889214 . + 0 Mb0817 possible monooxygenase Mb0817, -, len: 101 aa. Equivalent to Rv0793, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Conserved hypothetical protein, similar to others e.g. NP_250888.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (114 aa); AE 001908|AE001908_7 hypothetical protein from Deinococcus radiodurans (101 aa), FASTA scores: opt: 215, E(): 3.1e-09, (40.4% identity in 99 aa overlap); NP_440966.1|NC_000911|D90908|PCC6803|D90908_2 unknown protein from Synechocystis sp. strain PCC 6803 (147 aa),FASTA scores: opt: 194, E(): 4.5e-08, (31.1% identity in 90 aa overlap); etc. Also similar to Rv2749|MTV002.14|AL0089|MTV002_15 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 143, E(): 0.00026, (26.9% identity in 93 aa overlap). Q7U194 No intermediary metabolism and respiration Rv0793 NC_002945.3 Mycobrowser_v2 CDS 889327 889938 . - 0 Mb0818c PROBABLE OXIDOREDUCTASE [SECOND PART] Mb0818c, -, len: 203 aa. Equivalent to 3' end of Rv0794c, len: 499 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 203 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa); and similar to various oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa); NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase, similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa); Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Haloferax volcanii (475 aa); P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity in 467 aa overlap); P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa overlap); etc. Note that previously known as lpdB. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Mb0818c into 2 parts, Mb0818 and Mb0819. Q7U193 No NC_002945.3 Mycobrowser_v2 CDS 889926 890825 . - 0 Mb0819c PROBABLE OXIDOREDUCTASE [FIRST PART] Mb0819c, -, len: 299 aa. Equivalent to 5' end of Rv0794c, len: 499 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 263 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa); and similar to various oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa); NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase, similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa); Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Haloferax volcanii (475 aa); P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity in 467 aa overlap); P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa overlap); etc. Note that previously known as lpdB. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Mb0818c into 2 parts, Mb0818a and Mb0818b. Q7U192 No NC_002945.3 Mycobrowser_v2 CDS 933752 934780 . - 0 Mb0860c HYPOTHETICAL PROTEIN Mb0860c, -, len: 342 aa. Equivalent to Rv0837c,len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 342 aa overlap). Hypothetical unknown protein. TBparse score is 0.941. Q7U156 No conserved hypotheticals Rv0837c NC_002945.3 Mycobrowser_v2 CDS 891218 892312 . + 0 Mb0820 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1547 Mb0820, -, len: 364 aa. Equivalent to Rv0797, len 364 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 364 aa overlap). Putative transposase for IS1547; almost identical to (but 20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium tuberculosis (383 aa). Also similar to other transposases e.g. MAIS1110A _1|Q48909 transposase from M. avium (464 aa), FASTA scores: opt: 226, E(): 2.4e-08, (30.7% identity in 199 aa overlap). Also slight similarity to Rv2014|MTCY39.03c from Mycobacterium tuberculosis (222 aa), FASTA score: (24.8% identity in 141 aa overlap). Q7U191 No insertion seqs and phages Rv0797 NC_002945.3 Mycobrowser_v2 CDS 893096 894103 . - 0 Mb0822c conserved protein Mb0822c, -, len: 335 aa. Equivalent to Rv0799c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Conserved hypothetical protein, similar to Q50021|U2266C from Mycobacterium leprae (146 aa), FASTA scores: opt: 147,E(): 0.0016, (33.3% identity in 117 aa overlap); Q50020|U2266B from Mycobacterium leprae (27 aa), FASTA scores: opt: 94, E(): 1.3, (56.5% identity in 23 aa overlap). Also highly similar to others e.g. CAC01593.1|AL391041 conserved hypothetical protein from Streptomyces coelicolor (316 aa); AF088897|AF088897_9 hypothetical protein from Zymomonas mobilis (322 aa),FASTA scores: opt: 1132, E(): 0, (56.1% identity in 303 aa overlap); P76536|ECAE000330_8 hypothetical protein from Escherichia coli strain K-12 (308 aa), FASTA scores: E(): 2.2e-30, (37.4% identity in 297 aa overlap); etc. Also similar to some tyrA proteins. Q7U189 No conserved hypotheticals Rv0799c NC_002945.3 Mycobrowser_v2 CDS 894148 895449 . + 0 Mb0823 pepC PROBABLE AMINOPEPTIDASE PEPC Mb0823, pepC, len: 433 aa. Equivalent to Rv0800,len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 433 aa overlap). Probable pepC,aminopeptidase I (EC 3.4.11.-), highly similar (but shorter 17 aa) to Q50022|PEPX AMINOPEPTIDASE from Mycobacterium leprae (443 aa), FASTA scores: opt: 2237,E(): 0, (78.3% identity in 433 aa overlap). Also highly similar to others from Eukaryotes and bacteria, e.g. T36482 probable aminopeptidase from Streptomyces coelicolor (432 aa), P14904|AMPL_YEAST vacuolar aminopeptidase I precursor from Saccharomyces cerevisiae (514 aa), FASTA scores: opt: 425, E(): 4.8e-21, (31.0% identity in 445 aa overlap); etc. Also similar to hypothetical proteins e.g. P38821|YHR3_YEAST hypothetical 54.2 kd protein from Saccharomyces cerevisiae (490 aa),FASTA scores: opt: 429, E(): 2.5e-21, (34.8% identity in 443 aa overlap); etc. X2BG29,P59951 No intermediary metabolism and respiration Rv0800 NC_002945.3 Mycobrowser_v2 CDS 895461 895808 . + 0 Mb0824 conserved protein Mb0824, -, len: 115 aa. Equivalent to Rv0801, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins from Streptomyces sp. e.g. SCD840A.20|AB81865.1|AL161691 hypothetical protein from Streptomyces coelicolor (145 aa); AF072709|AF072709_8 from Streptomyces lividans (131 aa), FASTA scores: opt: 120,E(): 0.2, (26.3% identity in 118 aa overlap); etc. Q7U188 No conserved hypotheticals Rv0801 NC_002945.3 Mycobrowser_v2 CDS 895802 896458 . - 0 Mb0825c possible succinyltransferase in the gcn5-related n-acetyltransferase family Mb0825c, -, len: 218 aa. Equivalent to Rv0802c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Conserved hypothetical protein, showing partial similarity with many acetyltransferases and hypothetical proteins e.g. P96579|BSUB0003_68 PROBABLE ACETYLTRANSFERASE from Bacillus subtilis (183 aa), FASTA scores: E(): 0.0044,(26.4% identity in 110 aa overlap). Q7U187 No intermediary metabolism and respiration Rv0802c NC_002945.3 Mycobrowser_v2 CDS 896650 898914 . + 0 Mb0826 purL PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) Mb0826, purL, len: 754 aa. Equivalent to Rv0803,len: 754 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 754 aa overlap). purL,phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3) (see citations below), equivalent to NP_302451.1|NC_002677 phosphoribosylformylglycinamidine synthase II from Mycobacterium leprae (754 aa). Also highly similar to others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor (752 aa); P12042|PURL_BACSU from Bacillus subtilis (742 aa), FASTA score: (44.7% identity in 716 aa); etc. Start was chosen by similarity. BELONGS TO THE FGAMS FAMILY. X2BG81,P0A5T9 No intermediary metabolism and respiration Rv0803 NC_002945.3 Mycobrowser_v2 CDS 899661 900617 . + 0 Mb0828 class iii cyclic nucleotide phosphodiesterase (cnmp pde) Mb0828, -, len: 318 aa. Equivalent to Rv0805, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Conserved hypothetical protein, equivalent to Q50024 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa),FASTA scores: opt: 1713, E(): 0, (82.5% identity in 315 aa overlap). Also shows similarity with hypothetical proteins and icc proteins e.g. SC9B1.22c|T35867 hypothetical protein from Streptomyces coelicolor (305 aa); P36650|ICC_ECOLI icc protein from Escherichia coli (275 aa), FASTA scores: opt: 310, E(): 8.9e-14, (31.3% identity in 214 aa overlap); etc. Q7U185 No intermediary metabolism and respiration Rv0805 NC_002945.3 Mycobrowser_v2 CDS 900562 902160 . - 0 Mb0829c cpsY POSSIBLE UDP-GLUCOSE-4-EPIMERASE CPSY (GALACTOWALDENASE) (UDP-GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE-4-EPIMERASE) Mb0829c, cpsY, len: 532 aa. Equivalent to Rv0806c,len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 532 aa overlap). Possible cpsY,UDP-glucose-4-epimerase (EC 5.1.3.2), equivalent to Q50025|CPSY probable UDP-glucose-4-epimerase from Mycobacterium leprae (542 aa), FASTA scores: opt: 2964,E(): 0, (82.3% identity in 530 aa overlap). Also similar to AAC38286.1|AF019760|SACB CpsY homolog (involved in meningococcal capsule biosynthesis) from Neisseria meningitidis serogroup A (545 aa); Q51151 CAPSULE GENE COMPLEX UPD-GLUCOSE-4-EPIMERASE (GALE) from Neisseria meningitidis (373 aa), FASTA scores: opt: 496, E(): 9.5e-27, (29.3% identity in 358 aa overlap); C-terminus of CAB75373.1|AL139298 putative transferase from Streptomyces coelicolor (942 aa); and many hypothetical proteins from Streptomyces coelicolor. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY. X2BG73,Q7U184 No NC_002945.3 Mycobrowser_v2 CDS 902465 902854 . + 0 Mb0830 CONSERVED HYPOTHETICAL PROTEIN Mb0830, -, len: 129 aa. Equivalent to Rv0807, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, equivalent to O05761|MLCB5_31 HYPOTHETICAL 14.0 KD PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: E(): 0, (73.4% identity in 128 aa overlap). Also highly similar to BAA89438.1|AB003158|ORF3 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (132 aa); and C-terminus of SCD25.20|CAB56364.1|AL118514 hypothetical protein from Streptomyces coelicolor (202 aa). Q7U183 No conserved hypotheticals Rv0807 NC_002945.3 Mycobrowser_v2 CDS 902941 904524 . + 0 Mb0831 purF amidophosphoribosyltransferase purf (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpatase) Mb0831, purF, len: 527 aa. Equivalent to Rv0808,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 527 aa overlap). Probable purF,amidophosphoribosyltransferase (EC 2.4.2.14), equivalent to MLCB5_32|Q50028|PURF from Mycobacterium leprae (556 aa), FASTA scores: (91.3% identity in 518 aa overlap); and CAB96578.1|AJ278609 phosphoribosyl pyrophosphate amidotransferase from Mycobacterium smegmatis (511 aa). Also highly similar to others e.g. BAA89439.1|AB003158 amidophosphoribosyl transferase from Corynebacterium ammoniagenes (490 aa); P00497|PUR1_BACSU amidophosphoribosyltransferase precursor from Bacillus subtilis (476 aa), FASTA scores: opt: 1412, E(): 0, (46.2% identity in 470 aa overlap); etc. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. X2BG87,P65830 No intermediary metabolism and respiration Rv0808 NC_002945.3 Mycobrowser_v2 CDS 1506219 1506581 . - 0 Mb1377c CONSERVED MEMBRANE PROTEIN Mb1377c, -, len: 120 aa. Equivalent to Rv1342c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 120 aa overlap). Conserved membrane protein. Highly similar to G466926|P54133 hypothetical protein B1549_F2_59 from Mycobacterium leprae (119 aa),FASTA scores, opt: 544, E(): 1.9e-29, (68.3 % identity in 120 aa overlap). X2BHM0,P0A5E8 No cell wall and cell processes Rv1342c NC_002945.3 Mycobrowser_v2 CDS 904555 905649 . + 0 Mb0832 purM PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) Mb0832, purM, len: 364 aa. Equivalent to Rv0809,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Probable purM,5'-phosphoribosyl-5-aminoimidazole synthetase (EC 6.3.3.1), equivalent to NP_302446.1|NC_002677 5'-phosphoribosyl-5-aminoimidazole synthase from Mycobacterium leprae (364 aa). Also highly similar to many e.g. P12043|PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE from Bacillus subtilis (346 aa), FASTA scores: opt: 1023, E(): 0, (46.5% identity in 331 aa overlap); U68765|STU68765_2 from Salmonella typhimurium (345 aa), FASTA scores: opt: 1014, E():0, (47.6% identity in 330 aa overlap); etc. Q7U182 No intermediary metabolism and respiration Rv0809 NC_002945.3 Mycobrowser_v2 CDS 905735 905917 . - 0 Mb0833c CONSERVED HYPOTHETICAL PROTEIN Mb0833c, -, len: 60 aa. Equivalent to Rv0810c, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Conserved hypothetical protein, with its N-terminus highly similar to NP_302445.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (62 aa); and AL118514|SCD25_24 hypothetical protein from Streptomyces coelicolor (84 aa),FASTA scores: opt: 180, E(): 5.7e-07, (51.8% identity in 56 aa overlap). TBparse score is 0.876. Q7U181 No conserved hypotheticals Rv0810c NC_002945.3 Mycobrowser_v2 CDS 906064 907170 . - 0 Mb0834c conserved protein Mb0834c, -, len: 368 aa. Equivalent to Rv0811c,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 368 aa overlap). Conserved hypothetical protein, equivalent to U2266F|U15182|MLU15182_13 HYPOTHETICAL PROTEIN from Mycobacterium leprae (366 aa), FASTA scores: opt: 1870,E(): 0, (77.4% identity in 367 aa overlap). Also highly similar to BAA89441.1|AB003158|ORF4 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (359 aa); and CAB94085.1|AL358692 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (321 aa). Q7U180 No conserved hypotheticals Rv0811c NC_002945.3 Mycobrowser_v2 CDS 907253 908122 . + 0 Mb0835 PROBABLE AMINO ACID AMINOTRANSFERASE Mb0835, -, len: 289 aa. Equivalent to Rv0812, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 289 aa overlap). Probable amino acid aminotransferase (EC 2.6.1.-), similar to other amino acid aminotransferases, generelly CLASS-IV OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, and especially ILVE proteins and PABC proteins e.g. B76065.1|AL157953 putative aminotransferase from Streptomyces coelicolor (273 aa); NP_069766.1|NC_000917 branched-chain amino acid aminotransferase (ilvE) from Archaeoglobus fulgidus (290 aa); P54692|DAAA_BACLI D-ALANINE AMINOTRANSFERASE from Bacillus licheniformis (283 aa); P28305|PABC_ECOLI 4-AMINO-4-DEOXYCHORISMATE LYASE From Escherichia coli (269 aa), FASTA scores: opt: 165, E(): 0.00064, (26.8% identity in 198 aa overlap); etc. Note that previously known as pabC. Q7U179 No intermediary metabolism and respiration Rv0812 NC_002945.3 Mycobrowser_v2 CDS 908168 908848 . - 0 Mb0836c conserved protein Mb0836c, -, len: 226 aa. Equivalent to Rv0813c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Conserved hypothetical protein, highly similar to U15182|MLU15182_16 HYPOTHETICAL PROTEIN from Mycobacterium leprae (242 aa),FASTA scores: opt: 1191, E(): 0, (78.3% identity in 226 aa overlap); and NP_302442.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (228 aa). Also similar to AB94083.1|AL358692|SCD66.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (191 aa); and Rv2717c|MTCY05A6_37 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (164 aa), FASTA score: (30.4% identity in 171 aa overlap). X2BG93,Q7U178 No conserved hypotheticals Rv0813c NC_002945.3 Mycobrowser_v2 CDS 909011 909313 . - 0 Mb0837c sseC2 conserved protein ssec2 Mb0837c, sseC2, len: 100 aa. Equivalent to Rv0814c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). sseC2, conserved hypothetical protein, highly similar to AAA62972.1|U15182|MLU15182_17 hypothetical protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 545,E(): 0, (84.0% identity in 100 aa overlap); and NP_302441.1|NC_002677|Z95150|MTCY164_29 conserved hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 647, E(): 0, (100.0% identity in 100 aa overlap). Also highly similar to M29612|SERCYSA_5 rhodanese-like protein from Saccharopolyspora erythraea (101 aa), FASTA scores: opt: 345, E(): 1.2e-18, (57.1% identity in 98 aa overlap); and similar at the C-terminus to the C-terminus of CAB94069.1|AL358692 conserved hypothetical protein from Streptomyces coelicolor (95 aa). Identical second copy present as Rv3118|MTCY164.28|SSEC1 from Mycobacterium tuberculosis (100 aa) (100.0% identity in 100 aa overlap). Q7U177 No NC_002945.3 Mycobrowser_v2 CDS 909315 910148 . - 0 Mb0838c cysA2 PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) Mb0838c, cysA2, len: 277 aa. Equivalent to Rv0815c,len: 277 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 277 aa overlap). Probable cysA2,thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER PUTATIVE THIOSULFATE SULFURTRANSFERASE from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa); NP_293941.1|NC_001263 thiosulfate sulfurtransferase from Deinococcus radiodurans (286 aa); etc. Identical second copy present as Rv3117|MTCY164.27|MT3199|O05793|cysA3 (277 aa) (100.0% identity in 277 aa overlap). Contains PS00683 Rhodanese C-terminal signature at C-terminus. BELONGS TO THE RHODANESE FAMILY. X2BG48,P59989 No NC_002945.3 Mycobrowser_v2 CDS 910441 910863 . - 0 Mb0839c thiX PROBABLE THIOREDOXIN THIX Mb0839c, thiX, len: 140 aa. Equivalent to Rv0816c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable thiX,thioredoxin (EC 1.-.-.-), equivalent to ThiX|U15182|MLU15182_21 thioredoxin from Mycobacterium leprae (172 aa), FASTA scores: opt: 556, E(): 8.8e-31,(63.8% identity in 141 aa overlap); and similar to AAL08576.1|AF418548_2|AF418548 thioredoxin from Mycobacterium avium subsp. paratuberculosis (117 aa). Also similar to other bacterial thioredoxins e.g. CAB95303.1|AL359779 putative thioredoxin from Streptomyces coelicolor (126 aa); P33791|THIO_STRAU|TRX|TRXA THIOREDOXIN from Streptomyces aureofaciens (106 aa); etc. And similar to Rv3914|MT4033|MTV028.05|NP_218431.1|NC_000962|trxC THIOREDOXIN (TRX) (MPT46) from Mycobacterium tuberculosis (116 aa). Has hydrophobic stretch at N-terminus. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY. Q7U176 No NC_002945.3 Mycobrowser_v2 CDS 911802 912569 . + 0 Mb0841 TRANSCRIPTIONAL REGULATORY PROTEIN Mb0841, -, len: 255 aa. Equivalent to Rv0818, len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 255 aa overlap). Probable transcriptional regulatory protein, highly similar to Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 945, E(): 0, (61.5 identity in 239 aa overlap); and similar to others from other organisms. Also similar to Rv2884|MTCY274.15|Z74024 from Mycobacterium tuberculosis (252 aa), FASTA scores: opt: 662, E(): 0, (47.8% identity in 226 aa overlap). Q7U174 No regulatory proteins Rv0818 NC_002945.3 Mycobrowser_v2 CDS 912566 913513 . + 0 Mb0842 mshd gcn5-related n-acetyltransferase, mshd Mb0842, -, len: 315 aa. Equivalent to Rv0819, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 315 aa overlap). Conserved hypothetical protein, equivalent to U2266N|U15182|MLU15182_24 HYPOTHETICAL PROTEIN from Mycobacterium leprae (312 aa), FASTA scores: opt: 1540,E(): 0, (75.2% identity in 314 aa overlap). Also highly similar to CAB88484.1|AL353816 putative acetyltransferase from Streptomyces coelicolor (309 aa). X2BFZ8,Q7U173 No intermediary metabolism and respiration Rv0819 NC_002945.3 Mycobrowser_v2 CDS 913556 914332 . + 0 Mb0843 phoT PROBABLE PHOSPHATE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PHOT Mb0843, phoT, len: 258 aa. Equivalent to Rv0820,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 258 aa overlap). Probable phoT,phosphate-transport ATP-binding protein ABC transporter (see citation below), equivalent to PhoT|MLU15182_28|U15182 phosphate transport system ABC transporter from Mycobacterium leprae (258 aa), FASTA scores: opt: 1556, E(): 0, (91.5% identity in 258 aa overlap). Also highly similar to others e.g. CAB88472.1|AL353816 phosphate ABC transport system ATP-binding protein from Streptomyces coelicolor (258 aa); etc. Note that also highly similar to many PstB proteins e.g. AAC15686.1|AF045938|PstB putative ABC transporter nucleotide binding subunit from Mycobacterium smegmatis (258 aa). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BG54,Q7U172 No cell wall and cell processes Rv0820 NC_002945.3 Mycobrowser_v2 CDS 914388 915029 . - 0 Mb0844c phoY2 PROBABLE PHOSPHATE-TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PHOY2 Mb0844c, phoY2, len: 213 aa. Equivalent to Rv0821c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Probable phoY2,phosphate-transport system regulatory protein, highly similar to PhoY|MLU15182_29|U15182 phosphate transport system regulator from Mycobacterium leprae (222 aa), FASTA scores: opt: 1268, E(): 0, (93.0% identity in 213 aa overlap). Also similar to others e.g. NP_384620.1|NC_003047 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Sinorhizobium meliloti (237 aa); etc. Also highly similar to MTCI418A.03c|Z96070|PhoY1 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 937, E(): 0, (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY. TBparse score is 0.910. X2BG89,P65721 No NC_002945.3 Mycobrowser_v2 CDS 915087 917141 . - 0 Mb0845c conserved protein Mb0845c, -, len: 684 aa. Equivalent to Rv0822c,len: 684 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 684 aa overlap). Conserved hypothetical protein, highly similar in the region between aa 370 - 580 to U2266O|U15182|MLU15182_30 HYPOTHETICAL PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 819,E(): 0, (60.6% identity in 221 aa overlap). More extended similarity to Rv3267|Z92771|MTCY71_7 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 434, E(): 2.2e-17, (26.6% identity in 541 aa overlap), and Rv3484. Also similar to various proteins, preferiously putative membrane proteins and membrane-bound regulatory proteins e.g. CAC44512.1|AL596138 putative membrane protein from Streptomyces coelicolor (524 aa); U56901|BSU56901_1 regulatory protein from Bacillus subtilis (391 aa), FASTA scores: opt: 225, E(): 1.3e-05, (24.7% identity in 340 aa overlap). Contains hydrophobic stretch (aa ~ 160-195) and PS00041 Bacterial regulatory proteins, araC family signature. Q7U171 No conserved hypotheticals Rv0822c NC_002945.3 Mycobrowser_v2 CDS 922405 922695 . + 0 Mb0852 possible transposase (fragment) Mb0852, -, len: 96 aa. Equivalent to Rv0829, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 96 aa overlap). Possible transposase for IS1605' (fragment), similar to C-terminal end of many mycobacterial transposases and hypothetical proteins e.g. Z74024|MTCY274_16 from Mycobacterium tuberculosis (460 aa), FASTA scores: opt: 668, E(): 6.2e-32, (98.9% identity in 93 aa overlap); MTV002_57|O33333 TRANSPOSASE from Mycobacterium tuberculosis ; L07627|SERRY1_1 insertion element IS1136 from Saccharopolyspora erythraea (90 aa),FASTA score: (34.9% identity in 83 aa overlap). Q7U164 No insertion seqs and phages Rv0829 NC_002945.3 Mycobrowser_v2 CDS 1751151 1751555 . + 0 Mb1587 vapc11 possible toxin vapc11 Mb1587, -, len: 134 aa. Equivalent to Rv1561, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 134 aa overlap). Conserved hypothetical protein, similar to others from Mycobacterium tuberculosis e.g. Q10847|Rv2010|MTCY39.07c (132 aa), FASTA scores: (37.0% identity in 127 aa overlap); and O06566|Rv1114|MTCY22G8.03 (124 aa). X2BIQ3,P64880 No virulence, detoxification, adaptation Rv1561 NC_002945.3 Mycobrowser_v2 CDS 917307 918476 . - 0 Mb0846c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0846c, -, len: 389 aa. Equivalent to Rv0823c,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 389 aa overlap). Possible transcriptional regulator (resembles nitrogen regulation protein), equivalent (but longer 24 aa in N-terminus) to MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium leprae (384 aa), FASTA scores: opt: 2070, E(): 0, (82.3% identity in 384 aa overlap) (see citation below). Also highly similar to CAB63312.1|AL133471|SCC82.03c hypothetical protein from Streptomyces coelicolor (406 aa); and to many transcriptional regulators members of UPF0034 FAMILY (NIFR3/SMM1) e.g. D26185|BAC180K_143 protein similar to transcriptional regulator (nitrogen regulation protein) from Bacillus subtilis (333 aa), FASTA scores: opt: 609, E(): 1.4e-32, (38.3% identity in 326 aa overlap); NP_349795.1|NC_003030 NifR3 family enzyme from Clostridium acetobutylicum (321 aa); etc. Contains PS01136 Uncharacterized protein family UPF0034 signature. Q7U170 No regulatory proteins Rv0823c NC_002945.3 Mycobrowser_v2 CDS 918564 919580 . - 0 Mb0847c desA1 PROBABLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA1 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) (PROTEIN DES) Mb0847c, desA1, len: 338 aa. Equivalent to Rv0824c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 338 aa overlap). Probable desA1 (alternate gene name: des), acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.19.2) (see first citation below), equivalent to U15182|MLU15182_32 acyl-[ACP] desaturase from Mycobacterium leprae (338 aa),FASTA scores: opt: 1880, E(): 0, (79.9% identity in 338 aa overlap); and highly similar in part to fragment CAB96061.1|AJ250019 Steroyl-ACP-desaturase from Mycobacterium avium subsp. paratuberculosis (93 aa). Also similar to other fatty acid desaturases e.g. T35035 probable acyl-[acyl-carrier protein] desaturase from Streptomyces coelicolor (328 aa); Q40731|STAD_ORYSA ACYL-[ACYL-CARRIER PROTEIN] DESATURASE PRECURSOR from Oryza sativa (Rice) (390 aa); etc. Also highly similar to desA2|Rv1094 from Mycobacterium tuberculosis (275 aa). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. BELONGS TO THE FATTY ACID DESATURASE FAMILY. COFACTOR: FERREDOXIN, FERREDOXIN NADPH REDUCTASE,AND NADPH. Q7U169 No NC_002945.3 Mycobrowser_v2 CDS 919742 920383 . - 0 Mb0848c conserved protein Mb0848c, -, len: 213 aa. Equivalent to Rv0825c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, highly similar, but in part (between aa ~43-96) to fadD27|Rv0275c|MTV035.03 PUTATIVE FATTY-ACID-COA LIGASE from Mycobacterium tuberculosis (241 aa), FASTA scores: E(): 7.3e-09, (32.6% identity in 190 aa overlap). Also shows similarity with other proteins from Mycobacterium tuberculosis e.g. Rv0078|AL0214|MTV030_22 (201 aa), FASTA scores: opt:118, E(): 0.32, (34.5% identity in 113 aa overlap); etc. Q7U168 No conserved hypotheticals Rv0825c NC_002945.3 Mycobrowser_v2 CDS 920464 921519 . + 0 Mb0849 CONSERVED HYPOTHETICAL PROTEIN Mb0849, -, len: 351 aa. Equivalent to Rv0826, len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 351 aa overlap). Conserved hypothetical protein, similar to CAB94053.1|AL358672|SC7A12.06 hypothetical protein from Streptomyces coelicolor (300 aa); and NP_421372.1|NC_002696 hypothetical protein from Caulobacter crescentus (299 aa). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv1645c|Z85982|MTCY06H11.09 (351 aa), FASTA scores: opt: 1199, E(): 0, (57.5% identity in 299 aa overlap); Rv2237; Rv0276; etc. Q7U167 No conserved hypotheticals Rv0826 NC_002945.3 Mycobrowser_v2 CDS 925781 926194 . + 0 Mb0855 PE_PGRS12 pe-pgrs family protein pe_pgrs12 Mb0855, PE_PGRS12, len: 137 aa. Equivalent to Rv0832, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 137 aa overlap). Member of the Mycobacterium tuberculosis PE family, possibly PGRS subfamily of gly-rich proteins, highly similar to many others e.g. MTCY1A11.25c|Z78020 (498 aa), FASTA scores: opt: 529, E(): 5.2e-22, (61.8% identity in 136 aa overlap); etc. Appears to have incurred frameshift as next ORF should be continuation; sequence has been checked but no error found. Q7U161 No NC_002945.3 Mycobrowser_v2 CDS 921571 921963 . - 0 Mb0850c kmtr metal sensor transcriptional regulator kmtr (arsr-smtb family) Mb0850c, -, len: 130 aa. Equivalent to Rv0827c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Probable transcriptional regulator, similar to many e.g. CAC42856.1|AL592292 putative regulatory protein from Streptomyces coelicolor (115 aa); NP_301626.1|NC_002677 putative ArsR-family transcriptional regulator from Mycobacterium leprae (140 aa); BSUB0011_75|O31844|Z99114 YOZA PROTEIN from Bacillus subtilis (107 aa), FASTA scores: opt: 208, E(): 3.2e-08, (35.5% identity in 93 aa overlap); etc. Also similar to MTCY27.22c|Z95208 from Mycobacterium tuberculosis (135 aa), FASTA scores: opt: 201, E(): 1.2e-07, (35.7% identity in 98 aa overlap). Contains probable helix-turn helix motif from aa 42-63 (Score 1300, +3.61 SD). Q7U166 No regulatory proteins Rv0827c NC_002945.3 Mycobrowser_v2 CDS 1108623 1108955 . - 0 Mb1018c conserved serine rich protein Mb1018c, -, len: 110 aa. Equivalent to Rv0991c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Conserved hypothetical ser-rich protein (especially in C-terminus), highly similar to N-terminus of NP_301255.1|NC_002677 conserved hypothetical protein (Ser-rich C-terminus) from Mycobacterium leprae (99 aa). Also highly similar to SCE22.04|AB90971.1|AL355832 hypothetical protein from Streptomyces coelicolor (110 aa); and similar to others. Q7U0W5 No conserved hypotheticals Rv0991c NC_002945.3 Mycobrowser_v2 CDS 922021 922443 . - 0 Mb0851c POSSIBLE DEAMINASE Mb0851c, -, len: 140 aa. Equivalent to Rv0828c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Possible deaminase (EC 3.5.-.-), with its N-terminus highly similar to middle part of NP_302602.1|NC_002677 possible cytidine/deoxycytidylate deaminase from Mycobacterium leprae (171 aa). Also similar to other deaminases e.g. CAC18715.2|AL451182 putative deaminase from Streptomyces coelicolor (167 aa); NP_251189.1|NC_002516 probable deaminase from Pseudomonas aeruginosa (151 aa); NP_108387.1|NC_002678 nitrogen fixation protein gene from Mesorhizobium loti (149 aa); etc. Also similar to many conserved hypothetical proteins e.g. NP_389200.1|NC_000964 hypothetical protein from Bacillus subtilis (156 aa),FASTA scores: E(): 1.3e-07, (38.9% identity in 95 aa overlap); etc. And similar to Rv3752c possible deaminase from Mycobacterium tuberculosis. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. Q7U165 No intermediary metabolism and respiration Rv0828c NC_002945.3 Mycobrowser_v2 CDS 922800 923705 . + 0 Mb0853 possible s-adenosylmethionine-dependent methyltransferase Mb0853, -, len: 301 aa. Equivalent to Rv0830, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, member of Mycobacterium tuberculosis protein family consisting of the proteins Rv0726c,Rv0731c, Rv3399, Rv1729c|Z81360|MTCY4C12_14c (312 aa),FASTA scores: opt: 1014, E(): 0, (54.1% identity in 292 aa overlap); etc. X2BG66,Q7U163 No lipid metabolism Rv0830 NC_002945.3 Mycobrowser_v2 CDS 923724 924539 . - 0 Mb0854c conserved protein Mb0854c, -, len: 271 aa. Equivalent to Rv0831c,len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 271 aa overlap). Conserved hypothetical protein, similar to Rv0347|MTY13E10_7|Z95324 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (328 aa), FASTA scores: opt: 426, E(): 2.6e-21, (33.6% identity in 262 aa overlap). Q7U162 No conserved hypotheticals Rv0831c NC_002945.3 Mycobrowser_v2 tRNA 924633 924705 . - 0 lysT lysT tRNA-Lys lysT, len: 73 nt. Equivalent to lysT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Lys, anticodon ttt. No NC_002945.3 Mycobrowser_v2 tRNA 924829 924902 . + 0 gluT gluT tRNA-Glu gluT, len: 74 nt. Equivalent to gluT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Glu, anticodon ttc. No NC_002945.3 Mycobrowser_v2 CDS 926191 928512 . + 0 Mb0856 PE_PGRS13 pe-pgrs family protein pe_pgrs13 Mb0856, PE_PGRS13, len: 773 aa. Equivalent to Rv0833, len: 749 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, but lacking N-terminal domain (present in preceding ORF),possibly due to frameshift. Similar in part to many others e.g. MTCY28_25|Z95890 (914 aa), FASTA scores: opt: 2726,E(): 0, (60.1% identity in 776 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 84 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (773 aa versus 749 aa). Q7U160 No NC_002945.3 Mycobrowser_v2 CDS 928739 931234 . - 0 Mb0857c PE_PGRS14 pe-pgrs family protein pe_pgrs14 Mb0857c, PE_PGRS14, len: 831 aa. Equivalent to Rv0834c, len: 882 aa, from Mycobacterium tuberculosis strain H37Rv. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many others e.g. MTCY493_4|Z95844 (1329 aa),FASTA scores: opt: 2577, E(): 0, (52.0% identity in 950 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 882 aa). Q7U159 No NC_002945.3 Mycobrowser_v2 CDS 931702 932346 . + 0 Mb0858 lpqQ POSSIBLE LIPOPROTEIN LPQQ Mb0858, lpqQ, len: 214 aa. Equivalent to Rv0835,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 214 aa overlap). Possible lpqQ,lipoprotein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U158 No cell wall and cell processes Rv0835 NC_002945.3 Mycobrowser_v2 CDS 1771950 1772465 . - 0 Mb1611c Possible phage phiRv1 protein Mb1611c, -, len: 171 aa. Equivalent to Rv1585c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Possible phage phiRv1 protein (see citation below). Q7VEX1 No insertion seqs and phages Rv1585c NC_002945.3 Mycobrowser_v2 CDS 935469 936245 . + 0 Mb0861 lpqR PROBABLE CONSERVED LIPOPROTEIN LPQR Mb0861, lpqR, len: 258 aa. Equivalent to Rv0838,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 258 aa overlap). Probable lpqR,conserved lipoprotein. Similar (except in N-terminus) to hypothetical proteins and D-alanyl-D-alanine dipeptidases e.g. NP_416005.1|NC_000913 hypothetical protein from Escherichia coli strain K12 (193 aa); NP_421076.1|NC_002696 D-alanyl-D-alanine dipeptidase from Caulobacter crescentus (212 aa); Q06241|VANX_ENTFC D-ALANYL-D-ALANINE DIPEPTIDASE from Enterococcus faecium (202 aa), FASTA scores: opt: 198, E(): 1.9e-05, (28.1% identity in 199 aa overlap); etc. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 6bp insertion (*-cggccc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). Q7U155 No cell wall and cell processes Rv0838 NC_002945.3 Mycobrowser_v2 CDS 2003144 2004937 . - 0 Mb1808c possible integral membrane protein Mb1808c, -, len: 597 aa. Equivalent to Rv1779c,len: 597 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 597 aa overlap). Possible integral membrane protein. Q7TZK0 No cell wall and cell processes Rv1779c NC_002945.3 Mycobrowser_v2 CDS 1009409 1010527 . + 0 Mb0930 conserved protein Mb0930, -, len: 372 aa. Equivalent to Rv0906, len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 372 aa overlap). Conserved hypothetical protein, highly similar to others e.g. SC6A5.25|AL049485|T35416 hypothetical protein from Streptomyces coelicolor (370 aa), FASTA scores: opt: 1125,E(): 0, (51.3% identity in 335 aa overlap); NP_242955.1|NC_002570|BH2089 conserved protein from Bacillus halodurans (370 aa); etc. Also shows some similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer membrane protein roma (fragment) from Klebsiella pneumoniae (132 aa), FASTA scores: opt: 319, E(): 8.5e-14,(46.2% identity in 104 aa overlap); NP_105215.1|NC_002678 hypothetical protein which contains similarity to outer membrane protein romA from Enterobacter cloacae (350 aa); etc. X2BGG4,P64760 No conserved hypotheticals Rv0906 NC_002945.3 Mycobrowser_v2 CDS 936332 937144 . + 0 Mb0862 CONSERVED HYPOTHETICAL PROTEIN Mb0862, -, len: 270 aa. Equivalent to Rv0839, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Conserved hypothetical protein, similar to various hypothetical proteins or methyltransferases from yeast and bacteria e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hypothetical protein from Streptomyces coelicolor (273 aa), FASTA scores: opt: 1102, E(): 0, (58.6% identity in 263 aa overlap); T38024|Z98598|SPAC1B3.06c hypothetical protein from Schizosaccharomyces pombe (278 aa), FASTA scores: opt: 562, E(): 1.9e-3, (36.4% identity in 269 aa overlap); JC6531 avermectin B 5-O-methyltransferase (EC 2.1.1.-) from Streptomyces avermitilis (283 aa); etc. Also similar to other Mycobacterium tuberculosis hypothetical proteins that may be methyltransferases e.g. Rv1523, Rv2952,Rv1405c, etc. Q7U154 No conserved hypotheticals Rv0839 NC_002945.3 Mycobrowser_v2 CDS 937212 938072 . - 0 Mb0863c pip PROBABLE PROLINE IMINOPEPTIDASE PIP (PROLYL AMINOPEPTIDASE) (PAP) Mb0863c, pip, len: 286 aa. Equivalent to Rv0840c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible pip, proline iminopeptidase (EC 3.4.11.5), similar to many e.g. P46541|PIP_BACCO PROLINE IMINOPEPTIDASE from BACILLUS COAGULANS (288 aa), FASTA scores: opt: 657, E(): 0, (37.6% identity in 282 aa overlap); NP_386922.1|NC_003047 PUTATIVE PROLINE IMINOPEPTIDASE PROTEIN from Sinorhizobium meliloti (296 aa); etc. BELONGS TO PEPTIDASE FAMILY S33. Q7U153 No NC_002945.3 Mycobrowser_v2 CDS 938348 938590 . + 0 Mb0864 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0864, -, len: 80 aa. Equivalent to Rv0841, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 80 aa overlap). Conserved transmembrane protein, highly similar to C-terminus of next ORF Rv0842|O53854 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis (442 aa), FASTA scores: opt: 246, E(): 3.3e-10, (59.7% identity in 72 aa overlap). Replace previous Rv0841c. Q7U152 No cell wall and cell processes Rv0841 NC_002945.3 Mycobrowser_v2 CDS 938867 940159 . + 0 Mb0865 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0865, -, len: 430 aa. Equivalent to Rv0842, len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 430 aa overlap). Probable conserved integral membrane protein, showing similarity with other integral membrane proteins e.g. P28246|BCR_ECOLI BICYCLOMYCIN RESISTANCE PROTEIN from EScherichia coli (396 aa), FASTA scores: opt: 216, E(): 5.4e-07, (23.7% identity in 376 aa overlap); etc. Q7U151 No cell wall and cell processes Rv0842 NC_002945.3 Mycobrowser_v2 CDS 940143 941147 . + 0 Mb0866 PROBABLE DEHYDROGENASE Mb0866, -, len: 334 aa. Equivalent to Rv0843, len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 334 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to various dehydrogenases e.g. Q46142|Q46142 TPP-DEPENDENT ACETOIN DEHYDROGENASE (326 aa), FASTA scores: opt: 500, E(): 2.4e-26, (32.3% identity in 300 aa overlap); P51267|ODPA_PORPU PYRUVATE DEHYDROGENASE E1 COMPONENT from Porphyra purpurea (344 aa), FASTA scores: opt: 451, E(): 4.7e-23, (29.6% identity in 311 aa overlap); etc. Also similar to Rv2497c|pdhA pyruvate dehydrogenase E1 component from Mycobacterium tuberculosis (367 aa). Q7U150 No intermediary metabolism and respiration Rv0843 NC_002945.3 Mycobrowser_v2 CDS 941211 941861 . - 0 Mb0867c narL POSSIBLE NITRATE/NITRITE RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN NARL Mb0867c, narL, len: 216 aa. Equivalent to Rv0844c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 216 aa overlap). Possible narL,nitrate/nitrite response regulator protein, similar to many e.g. CAB44989.1|AJ131854 NarL protein from Pseudomonas stutzeri (218 aa); CAA75536.1|Y15252 nitrate/nitrite regulatory protein from Pseudomonas aeruginosa (216 aa); PCC6803|D64005|SYCSLRG_24 NarL protein from Synechocystis sp. (209 aa), FASTA scores: opt: 438, E(): 1.5e-23, (34.6% identity in 208 aa overlap); etc. Also similar to unidentified regulator e.g. CAB76009.1|AL157916 putative two-component system response regulator from Streptomyces coelicolor (224 aa); etc. Contains probable helix-turn helix motif from aa 170-191 (Score 1124, +3.02 SD). Q7U149 No NC_002945.3 Mycobrowser_v2 CDS 941945 943222 . + 0 Mb0868 POSSIBLE TWO COMPONENT SENSOR KINASE Mb0868, -, len: 425 aa. Equivalent to Rv0845, len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Possible two-component sensor kinase (EC 2.7.-.-), with its C-terminus similar to C-terminal part of others e.g. NP_294951.1|NC_001263 two-component sensor histidine kinase from Deinococcus radiodurans (469 aa); CAC32293.1|AL583943 putative two component system histidine kinase from Streptomyces coelicolor (404 aa); NP_464546.1|NC_003210 protein similar to two-component sensor histidine kinase from Listeria monocytogenes (352 aa); BSUB0017_193|Z9912 two-component sensor kinase from Bacillus subtilis (360 aa), FASTA scores: opt: 275, E(): 1.6e-11, (30.3% identity in 234 aa overlap); etc. Q7U148 No regulatory proteins Rv0845 NC_002945.3 Mycobrowser_v2 CDS 943435 944949 . - 0 Mb0869c PROBABLE OXIDASE Mb0869c, -, len: 504 aa. Equivalent to Rv0846c,len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 504 aa overlap). Probable oxidase (EC 1.-.-.-), showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins A (precursors) e.g. P24792|ASO_CUCMA L-ASCORBATE OXIDASE PRECURSOR (ASCORBASE) (EC 1.10.3.3) from Cucurbita maxima (Pumpkin) (Winter squash) (579 aa), FASTA scores: opt: 423, E(): 5.8e-18, (28.4% identity in 493 aa overlap); AF010496|AF010496_32 potential multicopper oxidase from Rhodobacter capsulatus (491 aa), FASTA scores: opt: 490,E(): 2.7e-22, (28.8% identity in 510 aa overlap); 47452|PCOA_ECOLI COPPER RESISTANCE PROTEIN A PRECURSOR (BELONGS TO THE FAMILY OF MULTICOPPER OXIDASES) from Escherichia coli strain K12 (605 aa); etc. Contains PS00080 Multicopper oxidases signature 2 at C-terminus. SEEMS TO BELONG TO THE FAMILY OF MULTICOPPER OXIDASES. Q7U147 No intermediary metabolism and respiration Rv0846c NC_002945.3 Mycobrowser_v2 CDS 945693 946811 . + 0 Mb0871 cysK2 POSSIBLE CYSTEINE SYNTHASE A CYSK2 (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE) Mb0871, cysK2, len: 372 aa. Equivalent to Rv0848,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 372 aa overlap). Possible cysK2,cysteine synthase A (EC 4.2.99.8), but could be also a cysteine synthase B (EC 4.2.99.8) cysM2-product, similar to many e.g. NP_109408.1|NC_002682 cysteine synthase from Mesorhizobium loti (357 aa); Q44004|CYSM_ALCEU CYSTEINE SYNTHASE from Alcaligenes eutrophus strain CH34 (Ralstonia eutropha) (339 aa), FASTA scores: opt: 511, E(): 1.7e-25,(35.0% identity in 314 aa overlap); etc. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE. Note that previously known as cysM3. Q7U145 No NC_002945.3 Mycobrowser_v2 CDS 946811 948070 . + 0 Mb0872 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Mb0872, -, len: 419 aa. Equivalent to Rv0849, len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 419 aa overlap). Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS) involved in transport of drug, showing similarity with others e.g. T35055 probable transport system permease protein from Streptomyces coelicolor (436 aa); NP_295031.1|NC_001263 major facilitator family protein from Deinococcus radiodurans (458 aa); NP_455659.1|NC_003198 putative membrane transporter from Salmonella enterica subsp. enterica serovar Typhi (402 aa); etc. Q7U144 No cell wall and cell processes Rv0849 NC_002945.3 Mycobrowser_v2 CDS 948067 948399 . + 0 Mb0873 PUTATIVE TRANSPOSASE (FRAGMENT) Mb0873, -, len: 110 aa. Equivalent to Rv0850, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Putative transposase (fragment), similar in part to others e.g. Q45144|Q4514 TRANSPOSABLE ELEMENT IS31831 (436 aa), FASTA scores: opt: 175, E(): 4.3e-05, (38.6% identity in 57 aa overlap); etc. Q7U143 No insertion seqs and phages Rv0850 NC_002945.3 Mycobrowser_v2 CDS 948396 949223 . - 0 Mb0874c probable short-chain type dehydrogenase/reductase Mb0874c, -, len: 275 aa. Equivalent to Rv0851c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 275 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to many e.g. Q01198|LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC 1.1.1.-)(SDR FAMILY) from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (305 aa); D11473|PSELIG_1 C alpha-dehydrogenase from P. paucimobilis (305 aa), FASTA scores: opt: 468, E(): 4.9e-23, (30.8% identity in 279 aa overlap); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U142 No intermediary metabolism and respiration Rv0851c NC_002945.3 Mycobrowser_v2 CDS 949314 950150 . + 0 Mb0875 fadD16 POSSIBLE FATTY-ACID-COA LIGASE FADD16 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0875, fadD16, len: 278 aa. Equivalent to Rv0852,len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Possible fadD16,fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to various CoA ligases e.g. P18163|LCFB_RAT LONG-CHAIN-FATTY-ACID--COA LIGASE from Rattus norvegicus (Rat) (699 aa); D49366|LEP4CCOALA_1 4-coumarate:CoA ligase from Lithospermum erythrorhizon (636 aa), FASTA scores: opt: 134, E(): 0.15, (26.8% identity in 213 aa overlap); orgp|L09229|HUMFACAL_1 long-chain acyl-coenzyme A from homo sapiens (human) (699 aa), FASTA score: (50.0% identity in 40 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7U141 No NC_002945.3 Mycobrowser_v2 CDS 1016702 1017151 . + 0 Mb0936 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0936, -, len: 149 aa. Equivalent to Rv0912, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 149 aa overlap). Probable conserved transmembrane protein, equivalent to Q50121|NP_302397.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 677, E(): 6.9e-38, (69.5% identity in 141 aa overlap). Q7U117 No cell wall and cell processes Rv0912 NC_002945.3 Mycobrowser_v2 CDS 950191 951873 . - 0 Mb0876c pdc PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC Mb0876c, pdc, len: 560 aa. Equivalent to Rv0853c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable pdc,pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-),equivalent to NP_302424.1|NC_002677 pyruvate (or indolepyruvate) decarboxylase from Mycobacterium leprae (569 aa). Also highly similar to others e.g. AAB06571.1|L80006 indolepyruvate decarboxylase from Pantoea agglomerans (550 aa); Q12629|DCPY_KLULA PYRUVATE DECARBOXYLASE (EC 4.1.1.1) from Kluyveromyces marxianus var. lactis (563 aa); P71323 INDOLEPYRUVATE DECARBOXYLASE (EC 4.1.1.74) from Enterobacter herbicola (550 aa), FASTA scores: opt: 1642, E(): 0, (48.1% identity in 547 aa overlap); P23234|DCIP_ENTCL INDOLE-3-PYRUVATE DECARBOXYLASE (INDOLEPYRUVATE DECARBOXYLASE) from Enterobacter cloacae (552 aa), FASTA scores: opt: 1596,E(): 0, (46.8% identity in 551 aa overlap); etc. Contains PS00187 Thiamine pyrophosphate enzymes signature and PS00017 ATP/GTP-binding site motif A (P-loop). COFACTOR: THIAMINE PYROPHOSPHATE. X2BGC9,Q7U140 No NC_002945.3 Mycobrowser_v2 CDS 951938 952381 . + 0 Mb0877 conserved protein Mb0877, -, len: 147 aa. Equivalent to Rv0854, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein, similar to several hypothetical protein from Mycobacterium leprae e.g. NP_301674.1|NC_002677 (144 aa); NP_302683.1|NC_002677|Z95398|MLCL622.27c (156 aa), FASTA scores: opt: 193, E(): 1.6e-06, (24.6% identity in 134 aa overlap); NP_301218.1|NC_002677 (146 aa); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 171, E(): 5.8e-05, (21.5% identity in 135 aa overlap). Also similar to SC6G10.02c|T35511|AL049497|SC6G10_2 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 344, E(): 6.1e- 17, (37.6% identity in 141 aa overlap). And similar to many proteins from Mycobacterium tuberculosis e.g. downstreams ORFs Rv0856 and Rv0857,etc. Q7U139 No conserved hypotheticals Rv0854 NC_002945.3 Mycobrowser_v2 CDS 952387 953466 . + 0 Mb0878 far PROBABLE FATTY-ACID-COA RACEMASE FAR Mb0878, far, len: 359 aa. Equivalent to Rv0855,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable far, fatty acid-CoA racemase (EC 5.1.-.-), highly similar to CAB08122.1|Z94723 unknown protein from Mycobacterium leprae (253 aa) (C-terminus shorter). Also similar to many eukaryotic and bacteria racemases e.g. T35425 probable fatty acid CoA racemase from Streptomyces coelicolor (387 aa); P70473|AMAC_RAT ALPHA-METHYLACYL-COA RACEMASE (2-METHYLACYL-COA RACEMASE) (2-ARYLPROPIONYL-COA EPIMERASE) (EC 5.1.99.4) from Rattus norvegicus (Rat) (382 aa); NP_103687.1|NC_002678 probable fatty acid Co-A racemase from Mesorhizobium loti (389 aa); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv1143|MTCI65.10|MCR from Mycobacterium tuberculosis (360 aa), FASTA scores: opt: 1373, E(): 0, (56.8% identity in 359 aa overlap), Rv1866|MTCY359.07 (C-terminal half) (778 aa), Rv3272 (360 aa). Q7U138 No lipid metabolism Rv0855 NC_002945.3 Mycobrowser_v2 CDS 953579 953983 . + 0 Mb0879 CONSERVED HYPOTHETICAL PROTEIN Mb0879, -, len: 134 aa. Equivalent to Rv0856, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Conserved hypothetical protein, showing weak similarity with NP_301674.1| (NC_002677) conserved hypothetical protein from Mycobacterium leprae (144 aa); and SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. neighbouring ORF downstream Rv0857 CONSERVED HYPOTHETICAL PROTEIN (126 aa),FASTA scores: E(): 7.4e-27, (62.0% identity in 100 aa overlap); neighbouring ORF Rv0854|MTV043_47 CONSERVED HYPOTHETICAL PROTEIN (147 aa), FASTA scores: E(): 1.6e-15,(36.6% identity in 123 aa overlap),MTCI28.04|Z97050|MTCI28_4 (184 aa), FASTA scores: opt: 127, E(): 0.036, (26.0% identity in 127 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 123, E(): 0.06, (26.4% identity in 125 aa overlap). Q7U137 No conserved hypotheticals Rv0856 NC_002945.3 Mycobrowser_v2 CDS 2005157 2005720 . + 0 Mb1809 conserved protein Mb1809, -, len: 187 aa. Equivalent to Rv1780, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Conserved hypothetical protein, equivalent to Q49881|ML1380|U00021_2 cosmid L247 from Mycobacterium leprae (187 aa), FASTA scores: opt: 1000, E(): 0, (82.4% identity in 187 aa overlap). Q7TZJ9 No conserved hypotheticals Rv1780 NC_002945.3 Mycobrowser_v2 CDS 954011 954484 . + 0 Mb0880 CONSERVED HYPOTHETICAL PROTEIN Mb0880, -, len: 157 aa. Equivalent to Rv0857, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 157 aa overlap). Conserved hypothetical protein, showing weak similarity with SC6G10.02|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF Rv0856 (134 aa), FASTA scores: E(): 9.6e-28, (61.6% identity in 99 aa overlap); upstream ORF Rv0854 (147 aa), FASTA scores: E(): 2.8e-18, (42.7% identity in 117 aa overlap); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 122, E(): 0.031, (29.4% identity in 85 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 114, E(): 0.1, (30.9% identity in 55 aa overlap). Q7U136 No conserved hypotheticals Rv0857 NC_002945.3 Mycobrowser_v2 CDS 954481 955674 . - 0 Mb0881c dapc probable n-succinyldiaminopimelate aminotransferase dapc (dap-at) Mb0881c, -, len: 397 aa. Equivalent to Rv0858c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Probable aminotransferase (EC 2.6.1.-), highly similar to others from Eukaryota and bacteria, especially aspartate aminotransferases (transaminases) (EC 2.6.1.1), e.g. NP_177890.1|NC_003070 putative aminotransferase from Arabidopsis thaliana (440 aa); NP_419555.1|NC_002696 aminotransferase class I from Caulobacter crescentus (385 aa); NP_415133.1|NC_000913|AE0001|ECAE000165_8 putative aminotransferase from Escherichia coli strain K12 (386 aa), FASTA scores: opt: 830, E(): 0, (38.0% identity in 389 aa overlap); X99521|TAX99521_1 aspartate aminotransferase from Thermus aquaticus (383 aa), FASTA scores: opt: 702, E(): 0, (34.9% identity in 393 aa overlap); etc. Also similar to other putative aminotransferases from Mycobacterium tuberculosis e.g. Rv2294, Rv3565, etc. Q7U135 No intermediary metabolism and respiration Rv0858c NC_002945.3 Mycobrowser_v2 CDS 955831 957042 . + 0 Mb0882 fadA POSSIBLE ACYL-COA THIOLASE FADA Mb0882, fadA, len: 403 aa. Equivalent to Rv0859,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 403 aa overlap). Possible fadA,acyl-CoA thiolase (EC 2.3.1.-), equivalent to NP_302423.1|NC_002677 putative beta-ketoadipyl CoA thiolase from Mycobacterium leprae (403 aa). Also highly similar to acyl/acetyl-CoA thiolases and beta-ketoadipyl CoA thiolases, e.g. T35428 probable acetyl CoA acetyltransferase (thiolase) from Streptomyces coelicolor (404 aa); NP_250427.1|NC_002516 probable acyl-CoA thiolase from Pseudomonas aeruginosa (401 aa); NP_106253.1|NC_002678 probable acyl-CoA thiolase from Mesorhizobium loti (402 aa); NP_248919.1|NC_002516|PcaF beta-ketoadipyl CoA thiolase PcaF from Pseudomonas aeruginosa (401 aa); etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiolases signature 2 and PS00099 Thiolases active site. Q7U134 No lipid metabolism Rv0859 NC_002945.3 Mycobrowser_v2 CDS 957047 959209 . + 0 Mb0883 fadB PROBABLE FATTY OXIDATION PROTEIN FADB Mb0883, fadB, len: 720 aa. Equivalent to Rv0860,len: 720 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 720 aa overlap). Probable fadB, fatty oxidation protein, equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Also highly similar to others and various proteins involved in fatty acid metabolism, e.g. T35429 probable fatty oxidation protein from Streptomyces coelicolor (733 aa); NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (714 aa); NP_418895.1|NC_002696 fatty oxidation complex alpha subunit from Caulobacter crescentus (709 aa); P40939|ECHA_HUMAN TRIFUNCTIONAL ENZYME ALPHA SUBUNIT [INCLUDES: LONG-CHAIN ENOYL-COA HYDRATASE (EC 4.2.1.17); LONG CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (EC 1.1.1.35)] from Homo sapiens (763 aa), FASTA scores: opt: 1176, E(): 0, (32.4% identity in 722 aa overlap); P21177|FADB_ECOLI FATTY OXIDATION COMPLEX ALPHA SUBUNIT [INCLUDES: ENOYL-COA HYDRATASE (EC 4.2.1.17); DELTA(3)-CIS-DELTA(2)-TRANS-ENOYL-COA ISOMERASE (EC 5.3.3.8); 3-HYDROXYACYL-COA DEHYDROGENASE (EC 1.1.1.35); 3-HYDROXYBUTYRYL-COA EPIMERASE (EC 5.1.2.3)] from Escherichia coli strain K12 (729 aa), FASTA scores: opt: 873, E(): 0, (33.6% identity in 693 aa overlap); etc. Q7U133 No lipid metabolism Rv0860 NC_002945.3 Mycobrowser_v2 CDS 959277 960905 . - 0 Mb0884c ercc3 dna helicase ercc3 Mb0884c, -, len: 542 aa. Equivalent to Rv0861c,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 542 aa overlap). Probable DNA helicase (EC 3.6.1.-), equivalent to NP_302420.1|NC_002677 probable DNA helicase from Mycobacterium leprae (549 aa). Also highly similar to others (shorter than several eukaryotic enzymes) e.g. NP_218820.1|NC_000919|AE001217|AE0 01217_6 putative DNA repair helicase from Treponema pallidum (606 aa), FASTA scores: opt: 1275, E(): 0, (47.5% identity in 592 aa overlap); Q00578|RA25_YEAST DNA REPAIR HELICASE from Saccharomyces cerevisiae (843 aa), FASTA scores: opt: 777, E(): 0, (30.4% identity in 605 aa overlap); P49135|XPB_MOUSE DNA-REPAIR PROTEIN COMPLEMENTING XP-B CELLS from Mus musculus (Mouse) (783 aa), FASTA scores: opt: 761, E(): 0, (36.3% identity in 375 aa overlap); etc. SEEMS TO BELONG TO THE HELICASE FAMILY. Q7U132 No information pathways Rv0861c NC_002945.3 Mycobrowser_v2 CDS 961043 963313 . - 0 Mb0885c conserved protein Mb0885c, -, len: 756 aa. Equivalent to Rv0862c,len: 756 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 756 aa overlap). Conserved hypothetical protein, equivalent to NP_302419.1|NC_002677 possible DNA-binding protein from Mycobacterium leprae (753 aa); and highly similar (except in C-terminus) to MLCB57.01|Z99494|T45333 hypothetical protein from Mycobacterium leprae (>577 aa, truncated), FASTA scores: opt: 3047, E(): 0, (78.9% identity in 578 aa overlap). Also similar in part to SCD12A.03c|AB93395.1|AL357524 hypothetical protein from Streptomyces coelicolor (867 aa). Q7U131 No conserved hypotheticals Rv0862c NC_002945.3 Mycobrowser_v2 CDS 963665 964093 . + 0 Mb0888 moaC2 probable molybdenum cofactor biosynthesis protein c 2 moac2 Mb0888, moaC2, len: 142 aa. Similar to Rv0864, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable moaC2,molybdopterin cofactor biosynthesis protein, highly similar to others e.g. CAB59676.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (170 aa); NP_418834.1|NC_002696 molybdenum cofactor biosynthesis protein C from Caulobacter crescentus (186 aa); Y10817|ANY10817_3|T44852 molybdopterin co-factor synthesis protein moaC from Arthrobacter nicotinovorans plasmid pAO1 (169 aa), FASTA scores: opt: 491, E(): 2.4e-29, (51.0% identity in 151 aa overlap); etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 491, E(): 2.4e-29, (54.9% identity in 153 aa overlap); and O53376|Rv3324c|MOAC3|MTV016.24c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C3 (177 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. X2BG23,P0A5K7 No NC_002945.3 Mycobrowser_v2 CDS 964090 964572 . + 0 Mb0889 mog probable molybdopterin biosynthesis mog protein Mb0889, mog, len: 160 aa. Equivalent to Rv0865,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Probable mog,molybdopterin biosynthesis MOG protein, highly similar or similar to other molybdenum cofactor biosynthesis proteins e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa); CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa); P44645|MOG_HAEIN|MOGA|HI0336 MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Haemophilus influenzae (197 aa), FASTA scores: opt: 306, E(): 9e-13,(39.6% identity in 139 aa overlap); P28694|MOG_ECOLI MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Escherichia coli (195 aa), FASTA scores: opt: 265, E(): 3.6e-10, (34.2 identity in 146 aa overlap); etc. Also highly similar to Rv0984|MTV044.12|MOAB2 POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis (181 aa). Q7U129 No intermediary metabolism and respiration Rv0865 NC_002945.3 Mycobrowser_v2 CDS 1078830 1079126 . + 0 Mb0993 conserved protein Mb0993, -, len: 98 aa. Equivalent to Rv0968, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 98 aa overlap). Conserved hypothetical protein, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). X2BGN3 No conserved hypotheticals Rv0968 NC_002945.3 Mycobrowser_v2 CDS 964569 964994 . + 0 Mb0890 moaE2 probable molybdenum cofactor biosynthesis protein e2 moae2 (molybdopterin converting factor large subunit) (molybdopterin [mpt] converting factor, subunit 2) Mb0890, moaE2, len: 141 aa. Equivalent to Rv0866,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Probable moaE2,molybdopterin converting factor E (molybdopterin converting factor (subunit 2)), similar to others e.g. Y10817|ANY10817_4|T44853 molybdopterin biosynthesis protein E chain from Arthrobacter nicotinovorans plasmid pAO1 (155 aa), FASTA scores: opt: 460, E(): 3.5e-27, (49.3 identity in 146 aa overlap); CAC01331.1|AL390968 moaE-like protein from Streptomyces coelicolor (152 aa); NP_389313.1|NC_000964 molybdopterin converting factor (subunit 2) from Bacillus subtilis (157 aa); etc. Also highly similar to Rv3119|MOAE1|Z95150|MTCY164_30 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 321, E(): 5.9e-17, (40.9% identity in 132 aa overlap); and O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa). Q7TTR9 No NC_002945.3 Mycobrowser_v2 CDS 965012 965995 . - 0 Mb0891c rpfA POSSIBLE RESUSCITATION-PROMOTING FACTOR RPFA Mb0891c, rpfA, len: 327 aa. Equivalent to Rv0867c,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(). Possible rpfA, resuscitation-promoting factor (see citation below). N-terminus highly similar to N-terminal part (1-125 aa) of Z99494|MLCB57_3|NP_302417.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (174 aa), FASTA scores: opt: 785, E(): 1.8e-18, (63.0% identity in 200 aa overlap); and highly similar to C-terminus of NP_301299.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (375 aa); and middle part of NP_302360.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (157 aa). N-terminus also highly similar in part of three secreted proteins from Streptomyces coelicolor e.g. CAC09538.1|AL442120 putative secreted protein (244 aa). Regions highly similar to CAB76321.1|AL158060 putative membrane protein from Streptomyces coelicolor (121 aa); and middle part of CAB09664.1|Z96935 rpf from Micrococcus luteus (220 aa). Also highly similar in part to four resuscitation-promoting factors from Mycobacterium tuberculosis: Rv2450 (172 aa), Rv1009 (362 aa), Rv1884c (176 aa), and Rv2389c (154 aa). Contains a probable secretory signal sequence in N-terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (327 aa versus 407 aa). Q7U128 No NC_002945.3 Mycobrowser_v2 CDS 1027570 1028151 . + 0 Mb0945 POSSIBLE RESOLVASE Mb0945, -, len: 193 aa. Equivalent to Rv0921, len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 193 aa overlap). Possible resolvase for IS1535, highly similar to many bacterial resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 537, E(): 5.7e-29, (51.8% identity in 166 aa overlap). Presents an helix turn helix motif. Q7U109 No insertion seqs and phages Rv0921 NC_002945.3 Mycobrowser_v2 CDS 1185331 1186188 . + 0 Mb1091 CONSERVED HYPOTHETICAL PROTEIN Mb1091, -, len: 285 aa. Equivalent to Rv1062, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 285 aa overlap). Conserved hypothetical protein, some similarity to AL079356|SC6G9_10 hypothetical protein in Streptomyces coelicolor (289 aa), FASTA scores: opt: 556, E(): 1.2e-27, (39.0% identity in 287 aa overlap), and Z99111|BSUB0008_176 Bacillus subtilis (260 aa), FASTA scores: opt: 163, E(): 0.0013, (27.4% identity in 179aa overlap) Q7U0R4 No conserved hypotheticals Rv1062 NC_002945.3 Mycobrowser_v2 CDS 966443 966721 . - 0 Mb0892c moaD2 probable molybdenum cofactor biosynthesis protein d 2 moad2 (molybdopterin converting factor small subunit) (molybdopterin [mpt] converting factor, subunit 1) Mb0892c, moaD2, len: 92 aa. Equivalent to Rv0868c,len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Probable moaD2,molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to CAB88494.1|AL353816 putative molybdopterin converting factor from Streptomyces coelicolor (84 aa); and weakly similar to others MoaD proteins e.g. Z99111|BSUB0008_103 from Bacillus subtilis (77 aa), FASTA scores: opt: 86,E(): 2.8, (22.9% identity in 83 aa overlap); etc. Also some similarity with Rv3112|MOAD1|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 113, E(): 0.024, (31.3% identity in 83 aa overlap). Q7TTR8 No NC_002945.3 Mycobrowser_v2 CDS 966725 967807 . - 0 Mb0893c moaA2 probable molybdenum cofactor biosynthesis protein a2 moaa2 Mb0893c, moaA2, len: 360 aa. Equivalent to Rv0869c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 360 aa overlap). Probable moaA2,molybdenum cofactor biosynthesis protein, highly similar to others e.g. CAB59437.1|AL132644|SCI8_6 molybdenum cofactor biosynthesis protein A from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1336, E(): 0,(61.7% identity in 332 aa overlap); S57490|X78980|ANMOAA_1 molybdopterin cofactor synthesis protein from Arthrobacter nicotinovorans (fragment) (374 aa), FASTA scores: opt: 1059, E(): 0, (49.9% identity in 369 aa overlap); Q44118|MOAA_ARTNI PROBABLE MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A from Arthrobacter nicotinovorans plasmid pAO1 (355 aa); etc. Also similar to Rv3109|MTCY164.19|Z95150|MOAA1 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 657, E(): 0,(36.6% identity in 309 aa overlap). BELONGS TO THE MOAA / NIFB / PQQE FAMILY. X2BG27,P65385 No NC_002945.3 Mycobrowser_v2 CDS 967804 968193 . - 0 Mb0894c POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0894c, -, len: 129 aa. Equivalent to Rv0870c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 129 aa overlap). Possible conserved integral membrane protein, highly similar to other membrane proteins: putative secreted proteins or hypothetical proteins e.g. CAC08263.1| AL392146 putative integral membrane protein from Streptomyces coelicolor (138 aa); NP_233433.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (143 aa); NP_455572.1|NC_003198 putative membrane protein from Salmonella enterica subsp. enterica serovar Typhi (148 aa); P37065|YCCF_ECOLI HYPOTHETICAL 16.3 KD PROTEIN from Escherichia coli (148 aa), FASTA scores: opt: 183, E(): 1.9e-06, (36.6% identity in 134 aa overlap); etc. Q7U127 No cell wall and cell processes Rv0870c NC_002945.3 Mycobrowser_v2 CDS 968358 968765 . + 0 Mb0895 cspB PROBABLE COLD SHOCK-LIKE PROTEIN B CSPB Mb0895, cspB, len: 135 aa. Equivalent to Rv0871,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Probable cspB, cold shock-like protein B, equivalent to Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from Mycobacterium leprae (136 aa), FASTA scores: opt: 787,E(): 0, (86.0% identity in 136 aa overlap). Also highly similar (but often longer than) to others e.g. CAB93399.1|AL357524 cold shock protein B from Streptomyces coelicolor (127 aa); Q45099|CSPD_BACCE COLD SHOCK-LIKE PROTEIN CSPD from Bacillus cereus (66 aa); Y101 81|LLCSPB_1 cold shock protein from Lactococcus lactis (66 aa), FASTA scores: opt: 220, E(): 2.5e-07, (48.3% identity in 60 aa overlap); etc. SEEMS TO BELONG TO THE COLD-SHOCK DOMAIN (CSD) FAMILY. Q7U126 No virulence, detoxification, adaptation Rv0871 NC_002945.3 Mycobrowser_v2 CDS 968884 970710 . - 0 Mb0896c PE_PGRS15 pe-pgrs family protein pe_pgrs15 Mb0896c, PE_PGRS15, len: 608 aa. Equivalent to Rv0872c, len: 606 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 606 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see first citation below),similar to many e.g. MTCY24A1.04c|Z95207 (615 aa), FASTA scores: opt: 2636, E(): 0, (64.6% identity in 619 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp in-frame deletion and a 9 bp in-frame insertion leads to a lightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (608 aa versus 606 aa). Q7U125 No NC_002945.3 Mycobrowser_v2 CDS 980971 981732 . - 0 Mb0907c CONSERVED HYPOTHETICAL PROTEIN Mb0907c, -, len: 253 aa. Equivalent to Rv0883c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 253 aa overlap). Conserved hypothetical protein, equivalent to O3306|MLCB57_16 CONSERVED HYPOTHETICAL PROTEI from Mycobacterium leprae (251 aa), FASTA scores: E(): 0, (79.4% identity in 253 aa overlap). Also highly similar to N_terminus of AL009204|SC9B10_22 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (352 aa), FASTA scores: E(): 6.1e-20, (35.0% identity in 246 aa overlap). X2BGF0 No conserved hypotheticals Rv0883c NC_002945.3 Mycobrowser_v2 CDS 970971 972923 . + 0 Mb0897 fadE10 PROBABLE ACYL-COA DEHYDROGENASE FADE10 Mb0897, fadE10, len: 650 aa. Equivalent to Rv0873,len: 650 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 650 aa overlap). Probable fadE10,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB91129.1|AL355913 putative acyl CoA dehydrogenase from Streptomyces coelicolor (658 aa); P50544|ACDV_MOUSE ACYL-COA DEHYDROGENASE from Mus musculus (656 aa); D30647|RATVLCAD_1 very-long-chain Acyl-CoA dehydrogenase from Rattus norvegicus (655 aa), FASTA scores: opt: 675, E(): 0, (33.9% identity in 380 aa overlap); etc. X2BGE3,P63430 No NC_002945.3 Mycobrowser_v2 CDS 973012 974172 . - 0 Mb0898c CONSERVED HYPOTHETICAL PROTEIN Mb0898c, -, len: 386 aa. Equivalent to Rv0874c,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Conserved hypothetical protein, highly similar in part to SPU62616_1 hypothetical protein from Synechococcus sp. (280 aa),FASTA scores: E(): 6.3e-26, (35.2% identity in 264 aa overlap); SYCSLLLH_102 from Synechocystis sp. (447 aa),FASTA scores: E(): 1.1e-18, (29.5% identity in 400 aa overlap). Also highly similar to Rv0628c|MTCY20H10_9 from Mycobacterium tuberculosis (383 aa), FASTA scores: E():0,(81.5% identity in 383 aa overlap). X2BG28,P0A5D4 No conserved hypotheticals Rv0874c NC_002945.3 Mycobrowser_v2 CDS 974272 974760 . - 0 Mb0899c POSSIBLE CONSERVED EXPORTED PROTEIN Mb0899c, -, len: 162 aa. Equivalent to Rv0875c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible conserved exported protein, equivalent to MLCB57_11|O33056 possible exported protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 789, E(): 0, (71.4% identity in 161 aa overlap). X2BGA5 No cell wall and cell processes Rv0875c NC_002945.3 Mycobrowser_v2 CDS 974757 976403 . - 0 Mb0900c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0900c, -, len: 548 aa. Equivalent to Rv0876c,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Possible conserved transmembrane protein, equivalent to MLCB57_12|O33057 possible membrane protein from Mycobacterium leprae (579 aa), FASTA scores: opt: 2850, E(): 0, (81.0% identity in 568 aa overlap). Also highly similar (except in N-terminus) to CAB93403.1|AL357524 putative integral membrane protein from Streptomyces coelicolor (463 aa). Q7U124 No cell wall and cell processes Rv0876c NC_002945.3 Mycobrowser_v2 CDS 976541 977329 . + 0 Mb0901 CONSERVED HYPOTHETICAL PROTEIN Mb0901, -, len: 262 aa. Equivalent to Rv0877, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Conserved hypothetical protein, equivalent to MLCB57_13|O33058 conserved hypothetical protein from Mycobacterium leprae (269 aa), FASTA scores: E(): 0, (80.5% identity in 257 aa overlap). Also highly similar (except in C-terminus) to SCD12A.13|CAB93404.1|AL357524 hypothetical protein from Streptomyces coelicolor (308 aa). X2BGF3 No conserved hypotheticals Rv0877 NC_002945.3 Mycobrowser_v2 CDS 977352 978668 . - 0 Mb0902c PPE13 ppe family protein ppe13 Mb0902c, PPE13, len: 438 aa. Equivalent to Rv0878c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. P4261|YHS6_MYCTU (517 aa), FASTA scores: opt: 1044, E(): 0, (47.4% identity in 397 aa overlap); MTV014_3, MTCI65_2, MTCY98_24, MTCY3C7_23, MTCY48_17,MTV004_5, MTV004_3, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (a-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Q7U123 No NC_002945.3 Mycobrowser_v2 CDS 978946 979221 . - 0 Mb0903c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0903c, -, len: 91 aa. Equivalent to Rv0879c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Possible conserved transmembrane protein, C-terminus highly similar to C-terminal part of MLCB57_14|O33059 conserved hypothetical protein from Mycobacterium leprae (91 aa), FASTA scores: E(): 1.2e-25, (76.9% identity in 91 aa overlap). X2BG33,P64736 No cell wall and cell processes Rv0879c NC_002945.3 Mycobrowser_v2 CDS 979399 979830 . + 0 Mb0904 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY MARR-FAMILY) Mb0904, -, len: 143 aa. Equivalent to Rv0880, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Possible transcriptional regulator, MarR family, equivalent to MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 818, E(): 0, (89.5% identity in 143 aa overlap). Also similar to many others e.g. CAB93410.1|AL357524 putative marR-family protein from Streptomyces coelicolor (145 aa); NP_251757.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (147 aa); etc. Also similar to Rv2327 from Mycobacterium tuberculosis (163 aa). X2BGB0,P67746 No regulatory proteins Rv0880 NC_002945.3 Mycobrowser_v2 CDS 987698 989170 . + 0 Mb0912 PROBABLE EXPORTED PROTEIN Mb0912, -, len: 490 aa. Equivalent to Rv0888, len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 490 aa overlap). Probable exported protein. Equivalent to AAK45157.1 from Mycobacterium tuberculosis strain CDC1551 (507 aa) but shorter 17 aa. Contains possible N-terminal signal sequence. X2BGF4,P64744 No cell wall and cell processes Rv0888 NC_002945.3 Mycobrowser_v2 CDS 979827 980693 . + 0 Mb0905 POSSIBLE RRNA METHYLTRANSFERASE (RRNA METHYLASE) Mb0905, -, len: 288 aa. Equivalent to Rv0881, len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 288 aa overlap). Possible rRNA methyltransferase (EC 2.1.1.-), highly similar to others and hypothetical proteins e.g. CAB76071.1|AL157953 putative rRNA methylase from Streptomyces coelicolor (272 aa); NP_421117.1|NC_002696 spoU rRNA methylase family protein from Caulobacter crescentus (268 aa); D90913_93|P74261 rRNA METHYLASE from Synechocystis sp. (274 aa), FASTA scores: E(): 1.1e-13, (26.3% identity in 278 aa overlap); P18644|TSNR_STRCN rRNA METHYLTRANSFERASE (EC 2.1.1.66) from Streptomyces cyaneus (Streptomyces curacoi) (269 aa), FASTA scores: E(): 3.7e-08, (23.9% identity in 268 aa overlap); etc. Equivalent to AAK45146.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 46 aa. X2BGE2,P59968 No intermediary metabolism and respiration Rv0881 NC_002945.3 Mycobrowser_v2 CDS 980690 980974 . + 0 Mb0906 PROBABLE TRANSMEMBRANE PROTEIN Mb0906, -, len: 94 aa. Equivalent to Rv0882, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Probable transmembrane protein. X2BGF8,P64738 No cell wall and cell processes Rv0882 NC_002945.3 Mycobrowser_v2 CDS 981889 983019 . - 0 Mb0908c serC POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC (PSAT) Mb0908c, serC, len: 376 aa. Equivalent to Rv0884c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible serC,phosphoserine aminotransferase (EC 2.6.1.52), equivalent to MLCB57_17 putative phosphoserine aminotransferase from Mycobacterium leprae (376 aa), FASTA scores: E(): 0, (87.5 identity in 376 aa overlap). Also highly similar to CAC08322.1|AL392149 putative aminotransferase from Streptomyces coelicolor (363 aa); and similar to other phosphoserine aminotransferases e.g. NP_386837.1|NC_003047 PUTATIVE PHOSPHOSERINE AMINOTRANSFERASE PROTEIN from Sinorhizobium meliloti (392 aa); P52878|SERC_METBA PHOSPHOSERINE AMINOTRANSFERASE from Methanosarcina barkeri (370 aa); P10658|SERC_RABIT|RABEPIP_1 PHOSPHOSERINE AMINOTRANSFERASE from Rabbit (370 aa), FASTA scores: opt: 271, E(): 3.5e-11, (24.5% identity in 368 aa overlap); etc. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BG34,P63515 No NC_002945.3 Mycobrowser_v2 CDS 983227 984249 . + 0 Mb0909 CONSERVED HYPOTHETICAL PROTEIN Mb0909, -, len: 340 aa. Equivalent to Rv0885, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Conserved hypothetical protein, equivalent to O33063|MLCB57_18 possible transmembrane protein from Mycobacterium leprae (341 aa), FASTA score: (83.9% identity in 341 aa overlap). Also similar except in C-terminus to T35630 probable membrane protein from Streptomyces coelicolor (312 aa). X2BGB3,P0A5D6 No conserved hypotheticals Rv0885 NC_002945.3 Mycobrowser_v2 CDS 984268 985995 . + 0 Mb0910 fprB PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) Mb0910, fprB, len: 575 aa. Equivalent to Rv0886,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 575 aa overlap). Probable fprB,ferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin oxidoreductase) (EC 1.18.1.2), equivalent to O3306|MLCB57_19 FERREDOXIN/FERREDOXIN--NADP REDUCTASE from Mycobacterium leprae (555 aa), FASTA scores: E(): 0, (76.6 identity in 560 aa overlap). Also highly similar or similar to others e.g. NP_294219.1|NC_001263 putative ferredoxin/ferredoxin--NADP reductase from Deinococcus radiodurans (479 aa) (N-terminus shorter); P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from homo sapiens (497 aa), FASTA scores: opt: 624, E(): 3e-30,(39.7% identity in 484 aa overlap); P08165|ADRO_BOVIN NADPH:ADRENODOXIN OXIDOREDUCTASE from Bos taurus (492 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv3106, Rv3858c, etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. X2BGE5,P65529 No intermediary metabolism and respiration Rv0886 NC_002945.3 Mycobrowser_v2 CDS 985978 986436 . - 0 Mb0911c CONSERVED HYPOTHETICAL PROTEIN Mb0911c, -, len: 152 aa. Equivalent to Rv0887c,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (194 aa), FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity in 131 aa overlap); etc. Also shows weak similarity with transposases and related proteins. X2BGG3 No conserved hypotheticals Rv0887c NC_002945.3 Mycobrowser_v2 CDS 989205 990326 . - 0 Mb0913c citA PROBABLE CITRATE SYNTHASE II CITA Mb0913c, citA, len: 373 aa. Equivalent to Rv0889c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Probable citA (alternate gene name: gltA), citrate synthase 2 (EC 4.1.3.7), highly similar to others e.g. CAB95899.1|AL359988 putative citrate synthase from Streptomyces coelicolor (387 aa); P39119|CISY_BACSU citrate synthase II from Bacillus subtilis (366 aa), FASTA scores: opt: 586, E(): 5.8e-30, (33.8% identity in 367 aa overlap); etc. Also similar to Rv0896|MTCY31.24 from Mycobacterium tuberculosis (29.2% identity in 274 aa overlap) and Rv1131. Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY. X2BG39,P63778 No NC_002945.3 Mycobrowser_v2 CDS 993063 993920 . - 0 Mb0915c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0915c, -, len: 285 aa. Equivalent to Rv0891c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Possible transcriptional regulator, highly similar in N-terminus to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar to several Mycobacterium tuberculosis putative transcriptional regulators e.g. Q1102|MTCY02B10_22 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (1159 aa),FASTA scores: opt: 702, E(): 8.3e-40, (50.6% identity in 247 aa overlap); MTV036_21; MTV008_44; MTCY02B10_23. Also shows similarity with several adenylate cyclases and hydrolases from other organisms. X2BGE9,P59970 No regulatory proteins Rv0891c NC_002945.3 Mycobrowser_v2 CDS 994318 995805 . + 0 Mb0916 PROBABLE MONOOXYGENASE Mb0916, -, len: 495 aa. Equivalent to Rv0892, len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Probable monooxygenase (EC 1.14.-.-), highly similar to others e.g. NP_250787.1|NC_002516 probable flavin-binding monooxygenase from Pseudomonas aeruginosa (491 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); P12015|CYMO_ACIS cyclohexanone monooxygenase from Acinetobacter sp. (542 aa), FASTA scores: opt: 489, E(): 6.8e-26, (30.3% identity in 492 aa overlap); etc. Also highly similar to Rv0565c, Rv3854c,Rv3083, etc from Mycobacterium tuberculosis. Has hydrophobic stretch at N-terminus. X2BGG8,P64746 No intermediary metabolism and respiration Rv0892 NC_002945.3 Mycobrowser_v2 CDS 1173329 1174234 . + 0 Mb1079 PROBABLE OXIDOREDUCTASE Mb1079, -, len: 301 aa. Equivalent to Rv1050, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). Probable oxidoreductase (EC 1.-.-.-) similar to many e.g. Rv1543|MTCY48.22C|Q10783 PUTATIVE OXIDOREDUCTASE CY48.22C (341 aa), FASTA scores: opt: 462, E(): 3e-22, (33.6% identity in 265 aa overlap). Q7U0S6 No intermediary metabolism and respiration Rv1050 NC_002945.3 Mycobrowser_v2 CDS 995783 996760 . - 0 Mb0917c possible s-adenosylmethionine-dependent methyltransferase Mb0917c, -, len: 325 aa. Equivalent to Rv0893c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 325 aa overlap). Conserved hypothetical protein, belongs in family with P96823|Rv0146|MTCI5.20 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 784, E(): 0, (43.2% identity in 308 aa overlap); Rv0726c,Rv0731c, Rv3399, etc. Also shows some similarity with others e.g. SC9B5.10|T35930 hypothetical protein from Streptomyces coelicolor (303 aa); BSUB0008_141|Q45500 HYPOTHETICAL 34.8 KD PROTEIN from Bacillus subtilis (304 aa), FASTA scores: E(): 0.00033, (26.8% identity in 168 aa overlap); etc. X2BGF9,P64748 No lipid metabolism Rv0893c NC_002945.3 Mycobrowser_v2 CDS 2078001 2078264 . - 0 Mb1870c vapb13 possible antitoxin vapb13 Mb1870c, -, len: 87 aa. Equivalent to Rv1839c, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Conserved hypothetical protein. Some similarity to G217008 CHO-ORF1 (279 aa),FASTA scores: opt: 86, E(): 13, (38.7% identity in 62 aa overlap). Q7TZG5 No virulence, detoxification, adaptation Rv1839c NC_002945.3 Mycobrowser_v2 CDS 996989 998170 . + 0 Mb0918 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY LUXR-FAMILY) Mb0918, -, len: 393 aa. Equivalent to Rv0894, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Possible regulatory protein, LuxR family, highly similar in part to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar to others e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); NP_107293.1|NC_002678 transcriptional regulator from Mesorhizobium loti (903 aa); etc. Also similar to other regulatory proteins from Mycobacterium tuberculosis e.g. Rv2488c|MTV008_44 (1137 aa), FASTA score: (53.2% identity in 363 aa overlap); Rv1358|MTCY02B10_22 (1159 aa), FASTA score: (52.3% identity in 365 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). X2BG43,P64750 No regulatory proteins Rv0894 NC_002945.3 Mycobrowser_v2 CDS 2507582 2508037 . - 0 Mb2278c Probable integral membrane protein Mb2278c, -, len: 151 aa. Equivalent to Rv2254c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 151 aa overlap). Probable integral membrane protein. Q7VEM8 No cell wall and cell processes Rv2254c NC_002945.3 Mycobrowser_v2 CDS 998247 999764 . + 0 Mb0919 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb0919, -, len: 505 aa. Equivalent to Rv0895, len: 505 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 505 aa overlap). Conserved hypothetical protein; member of family with: Rv3740c,Rv3734c, Rv1425, Rv1760, etc. Shows some similarity with NP_301898.1|NC_002677 conserved membrane protein from Mycobacterium leprae (491 aa). X2BGC4,P67205 No lipid metabolism Rv0895 NC_002945.3 Mycobrowser_v2 CDS 999937 1001232 . + 0 Mb0920 gltA2 PROBABLE CITRATE SYNTHASE I GLTA2 Mb0920, gltA2, len: 431 aa. Equivalent to Rv0896,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8%% identity in 431 aa overlap). Probable gltA2,citrate synthase 1 (EC 4.1.3.7), highly similar to O33066|NP_302405.1|NC_002677 citrate synthase 1 from Mycobacterium leprae (431 aa), FASTA scores: E(): 0, (91.0 identity in 431 aa overlap); and AAF04133.1|AF191033_1|AF191033 citrate synthase from Mycobacterium smegmatis (441 aa). Also highly similar to others e.g. AAF14286.1|AF181118_1|AF181118 citrate synthase from Streptomyces coelicolor (429 aa); P42457|CISY_CORGL CITRATE SYNTHASE from Corynebacterium glutamicum (437 aa), FASTA scores: opt: 1847, E(): 0,(63.0% identity in 433 aa overlap); etc. Also similar to two other Mycobacterium tuberculosis citrate synthases,Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (29.2% identity in 274 aa overlap) and Rv1131|MTCY22G8.20|gltA1 (393 aa). Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY. Q7U122 No NC_002945.3 Mycobrowser_v2 CDS 1001273 1002880 . - 0 Mb0921c PROBABLE OXIDOREDUCTASE Mb0921c, -, len: 535 aa. Equivalent to Rv0897c,len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 535 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases from diverse organisms e.g. CAB94055.1|AL358672 putative oxidoreductase from Streptomyces coelicolor (540 aa); NP_147877.1|NC_000854 phytoene dehydrogenase from Aeropyrum pernix (549 aa); Q01671|CRTD_RHOSH methoxyneurosporene dehydrogenase from Rhodobacter sphaeroides (495 aa), FASTA scores: opt: 139, E(): 2.6e-06, (23.8% identity in 538 aa overlap); etc. Also similar to Rv1432, Rv2997, and Rv3829c from Mycobacterium tuberculosis. X2BGH3,P64752 No intermediary metabolism and respiration Rv0897c NC_002945.3 Mycobrowser_v2 CDS 1003277 1004257 . + 0 Mb0923 ompA outer membrane protein a ompa Mb0923, ompA, len: 326 aa. Equivalent to Rv0899,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable ompA, outer membrane protein A, C-terminal region similar to C-terminus of many members of the OMPA family of outer membrane proteins e.g. NP_458280.1|NC_003198 putative outer membrane protein from Salmonella enterica subsp. enterica serovar Typhi (220); NP_418008.1|NC_000913 putative outer membrane protein from Escherichia coli strain K12 (219 aa), FASTA scores: opt: 296, E(): 2.2e-11,(45.3% identity in 117 aa overlap); NP_231844.1|NC_002505 outer membrane protein OmpA from Vibrio cholerae (321 aa); Q05146|OMPA_BORAV OUTER MEMBRANE PROTEIN A PRECURSOR from Bordetella avium (194 aa); etc. A signal peptide sequence probably exists at the N-terminus. Contains PS00044 Bacterial regulatory proteins, lysR family signature. BELONGS TO THE OMPA FAMILY. X2BG45,P65594 No cell wall and cell processes Rv0899 NC_002945.3 Mycobrowser_v2 CDS 1004270 1004422 . + 0 Mb0924 POSSIBLE MEMBRANE PROTEIN Mb0924, -, len: 50 aa. Equivalent to Rv0900, len: 50 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 50 aa overlap). Possible membrane protein,with hydrophobic domain from aa 4-26. X2BGD0,P64756 No cell wall and cell processes Rv0900 NC_002945.3 Mycobrowser_v2 CDS 1004422 1004949 . + 0 Mb0925 POSSIBLE CONSERVED EXPORTED OR MEMBRANE PROTEIN Mb0925, -, len: 175 aa. Equivalent to Rv0901, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 175 aa overlap). Possible conserved exported or membrane protein, with hydrophobic N-terminus at aa 7-25. Shows some similarity in C-terminus to O33070|Z99494|MLCB57.59 HYPOTHETICAL PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 204,E(): 3.2e-12, (44.9% identity in 78 aa overlap) X2BGG0,P64758 No cell wall and cell processes Rv0901 NC_002945.3 Mycobrowser_v2 CDS 1216207 1216512 . + 0 Mb1118 PE10 pe family protein pe10 Mb1118, PE10, len: 101 aa. Equivalent to Rv1089,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 101 aa overlap). Member of the Mycobacterium tuberculosis PE family of glycine-rich proteins. Partial ORF that appears to be frameshifted,continuation of Rv1088|MTV017.41. Sequence has been checked and appears correct. Similar to Z95555|MTCY06F7_4 Mycobacterium tuberculosis cosmid (401 aa), FASTA scores: opt: 126, E(): 2, (29.6% identity in 125 aa overlap). Q7U0P4 No PE/PPE Rv1089 NC_002945.3 Mycobrowser_v2 CDS 1004966 1006306 . - 0 Mb0926c prrB TWO COMPONENT SENSOR HISTIDINE KINASE PRRB Mb0926c, prrB, len: 446 aa. Equivalent to Rv0902c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 446 aa overlap). prrB, two-component sensor histidine kinase (EC 2.7.3.-) (see citations below), transmembrane protein, equivalent to MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase from Mycobacterium leprae (446 aa); and similar at C-termini to NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa). C-terminus also similar to the C-termini of many sensor-like histidine kinase proteins e.g. P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor protein from Escherichia coli strain K12 (457 aa), FASTA scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa overlap); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (483 aa); CAB82845.1|AJ277081 putative histidine kinase from Amycolatopsis mediterranei (472 aa); etc. Also similar in part to Mycobacterium tuberculosis proteins Rv3764c (475 aa); and Rv0982 (504 aa). Thought to be induced at phagocytosis (see second citation below). X2BGH8,P0A5Z9 No NC_002945.3 Mycobrowser_v2 CDS 1006317 1007027 . - 0 Mb0927c prrA TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA Mb0927c, prrA, len: 236 aa. Equivalent to Rv0903c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). prrA, two-component response regulator (see citations below), equivalent to Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component response regulator from Mycobacterium leprae (233 aa),FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa overlap); and similar to T45446 probable two-component response regulator from Mycobacterium leprae (253 aa). Also similar to many sensor-like histidine kinase proteins e.g. CAB88489.1|AL353816 putative two-component systen response regulator from Streptomyces coelicolor (248 aa); AAG36759.1|AF119221_1 |AF119221 response regulator from Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM transcriptional activator protein COPR from Pseudomonas syringae (pv. tomato) (227 aa), FASTA scores: opt: 600,E(): 0, (44.4% identity in 225 aa overlap); etc. Also similar to Rv0981 from Mycobacterium tuberculosis (230 aa), Rv3765c (234 aa), phoP (247 aa), etc. Thought to be induced at phagocytosis (see second citation below). X2BGG9,P0A5Z7 No NC_002945.3 Mycobrowser_v2 CDS 1007158 1008645 . - 0 Mb0928c accD3 PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE (SUBUNIT BETA) ACCD3 (ACCASE BETA CHAIN) Mb0928c, accD3, len: 495 aa. Equivalent to Rv0904c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 495 aa overlap). Putative accD3,acetyl-CoA carboxylase carboxyl transferase, beta subunit (carboxyltransferase subunit of acetyl-CoA carboxylase) (EC 6.4.1.2), highly similar in part to AAA63045.1|U15184 zinc finger protein from Mycobacterium leprae (201 aa). Also highly similar to others e.g. CAC42827.1|Y17592 putative carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum (491 aa); CAB86110.1|AL163003 putative acetyl CoA carboxylase (alpha and beta subunits) from Streptomyces coelicolor (458 aa); Q54776|ACCD_SYNP7 ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Synechococcus sp. (305 aa); P12217|ACCD_MARPO ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Marchantia polymorpha (316 aa), FASTA scores: opt: 519, E():1.6e-24, (40.2% identity in 219 aa overlap); etc. Also similar to Rv3280, Rv2502c,etc from Mycobacterium tuberculosis. BELONGS TO THE ACCD/PCCB FAMILY. X2BG50,P63406 No NC_002945.3 Mycobrowser_v2 CDS 1008672 1009403 . + 0 Mb0929 echA6 POSSIBLE ENOYL-COA HYDRATASE ECHA6 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0929, echA6, len: 243 aa. Equivalent to Rv0905,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 243 aa overlap). Possible echA6,enoyl-CoA hydratase (EC 4.2.1.17), highly similar to ML15184|U15184 enoyl-CoA hydratase from Mycobacterium leprae (247 aa), FASTA score: (85.8% identity in 247 aa overlap). Also similar to many e.g. NP_250320.1|NC_002516 probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa (261 aa); NP_415911.1|NC_000913 putative enzyme from Escherichia coli strain K12 (255 aa); P24162 ECHH_RHOCA|FADB1 enoyl-CoA hydratase homolog from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores: opt: 404, E():7.8e-21, (37.3% identity in 249 aa overlap); etc. X2BGD6,P64015 No NC_002945.3 Mycobrowser_v2 CDS 1010650 1012200 . + 0 Mb0931 conserved protein Mb0931, -, len: 516 aa. Equivalent to Rv0907, len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 511 aa overlap). Conserved hypothetical protein, possibly involved in cell wall biosynthesis: similar to many beta-lactamases, penicillin-binding proteins and hypothetical proteins e.g. NP_298910.1|NC_002488 beta-lactamase from Xylella fastidiosa (455 aa); Q06317|PBP4_NOCLA PENICILLIN-BINDING PROTEIN 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E(): 8.8e-05, (28.7% identity in 401 aa overlap); etc. N-terminus highly similar to AAA63047.1|U15184 hypothetical protein from Mycobacterium leprae (58 aa). Related to other putative esterases and penicillin binding proteins in Mycobacterium tuberculosis e.g. Rv1730c|MTCY04C12.15c (517 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U121 No cell wall and cell processes Rv0907 NC_002945.3 Mycobrowser_v2 CDS 1012197 1014590 . + 0 Mb0932 ctpE PROBABLE METAL CATION TRANSPORTER ATPASE P-TYPE CTPE Mb0932, ctpE, len: 797 aa. Equivalent to Rv0908,len: 797 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 797 aa overlap). Probable ctpE, metal cation-transporting ATPase P-type, transmembrane protein,E1-E2 family, highly similar to many e.g. AB93406.1|AL357524 putative integral membrane ATPase from Streptomyces coelicolor (802 aa); NP_346063.1|NC_003028 cation-transporting ATPase (E1-E2 family) from Streptococcus pneumoniae (778 aa); P37278|ATCL_SYNP7|PACL cation-transporting atpase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (926 aa), FASTA scores: opt: 257, E(): 4.8e-33, (27.7% identity in 905 aa overlap); etc. Contains E1-E2 ATPases phosphorylation site (PS00154). BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). X2BGH4,P0A505 No cell wall and cell processes Rv0908 NC_002945.3 Mycobrowser_v2 CDS 1015147 1015326 . + 0 Mb0933 CONSERVED HYPOTHETICAL PROTEIN Mb0933, -, len: 59 aa. Equivalent to Rv0909, len: 59 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 59 aa overlap). Conserved hypothetical protein, equivalent to NP_302399.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (56 aa). Also some similarity with AL022268|SC4H2_10c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (97 aa), FASTA scores: opt: 106, E(): 0.13, (43.2% identity in 37 aa overlap). Q7U120 No conserved hypotheticals Rv0909 NC_002945.3 Mycobrowser_v2 CDS 1015864 1016637 . + 0 Mb0935 conserved protein Mb0935, -, len: 257 aa. Equivalent to Rv0911, len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Conserved hypothetical protein, showing similarity with hydroxylases and hypothetical proteins e.g. T35325 probable hydroxylase from Streptomyces coelicolor (265 aa); Q54242 hypothetical protein from Streptomyces, FASTA scores: opt: 372, E(): 8.8e-18, (32.0% identity in 256 aa overlap); AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV from Streptomyces peucetius (275 aa); AAA63051.1|U15184 hypothetical protein from Mycobacterium leprae (94 aa); etc. Also similar to Rv0577 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (261 aa). Q7U118 No conserved hypotheticals Rv0911 NC_002945.3 Mycobrowser_v2 CDS 1025963 1027282 . - 0 Mb0944c probable transposase Mb0944c, -, len: 439 aa. Equivalent to Rv0920c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Probable transposase for IS1554, highly similar to others e.g. MTCY441.35|Q45111 transposase from Mycobacterium tuberculosis (419 aa), FASTA scores: opt: 1113, E(): 0,(43.9% identity in 378 aa overlap); etc. Contains transposases mutator family signature (PS01007). Q7U110 No insertion seqs and phages Rv0920c NC_002945.3 Mycobrowser_v2 CDS 1017683 1019191 . - 0 Mb0937c POSSIBLE DIOXYGENASE Mb0937c, -, len: 502 aa. Equivalent to Rv0913c,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 502 aa overlap). Possible dioxygenase (EC 1.-.-.-), showing similarity with others e.g. AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage dioxygenase from Phaseolus vulgaris (543 aa); CAB56138.1|AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); AAK06796.1|AF324838_15|AF324838 putative dioxygenase SimC5 from Streptomyces antibioticus (456 aa); Q53353|S65040 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE (EC 1.13.11.43) from Pseudomonas paucimobilis (485 aa), FASTA scores: opt: 310,E(): 3.4e-20, (28.9% identity in 495 aa overlap); etc. Also some similarity with Rv0654|MTCI376.22 PROBABLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa). Q7U116 No intermediary metabolism and respiration Rv0913c NC_002945.3 Mycobrowser_v2 CDS 1019193 1020431 . - 0 Mb0938c POSSIBLE LIPID CARRIER PROTEIN OR KETO ACYL-COA THIOLASE Mb0938c, -, len: 412 aa. Equivalent to Rv0914c,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 412 aa overlap). Possible lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16), highly similar to NP_421905.1|NC_002696 thiolase family protein from Caulobacter crescentus (407 aa); and similar to others e.g. NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase from Mesorhizobium loti (392 aa); NP_385796.1|NC_003047 PUTATIVE 3-KETOACYL-COA THIOLASE PROTEIN from Sinorhizobium meliloti (389 aa); NP_275932.1|NC_000916 lipid-transfer protein (sterol or nonspecific) from Methanothermobacter thermautotrophicus (383 aa); AB55378.1|AL117263 possible 3-ketoacyl-CoA thiolase from Leishmania major (441 aa), FASTA scores: opt: 547, E(): 3.1e-26, (31.0% identity in 435 aa overlap); etc. Also similar to Rv2790c, Rv1627c, Rv0244, etc from Mycobacterium tuberculosis. COULD BELONG TO THE THIOLASE FAMILY. Q7U115 No lipid metabolism Rv0914c NC_002945.3 Mycobrowser_v2 CDS 1020524 1021795 . - 0 Mb0939c PPE14 ppe family protein ppe14 Mb0939c, PPE14, len: 423 aa. Equivalent to Rv0915c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 423 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. Rv1807 from Mycobacterium tuberculosis (403 aa),FASTA scores: opt: 966, E(): 4.4e-30, (45.7% identity in 392 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7U114 No NC_002945.3 Mycobrowser_v2 CDS 1022553 1024334 . + 0 Mb0941 betP POSSIBLE GLYCINE BETAINE TRANSPORT INTEGRAL MEMBRANE PROTEIN BETP Mb0941, betP, len: 593 aa. Equivalent to Rv0917,len: 593 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 593 aa overlap). Possible betP, glycine betaine transporter, integral membrane protein, highly similar to many transporters, mainly glycine betaine transporters, e.g. P54582|BETP_CORGL glycine betaine transporter from Corynebacterium glutamicum (Brevibacterium flavum) (595 aa), FASTA scores: opt: 1367,E(): 0, (42.7% identity in 504 aa overlap); T35264 probable BCCT family transporter from Streptomyces coelicolor (578 aa); NP_243511.1|NC_002570 glycine betaine transporter from Bacillus halodurans (504 aa); NP_439848.1|NC_000907 high-affinity choline transport protein (betT) from Haemophilus influenzae (669 aa); etc. SEEMS TO BELONG TO THE BCCT (TC 2.33) FAMILY OF TRANSPORTERS. X2BGK1,P63696 No cell wall and cell processes Rv0917 NC_002945.3 Mycobrowser_v2 CDS 1024677 1025153 . + 0 Mb0942 conserved protein Mb0942, -, len: 158 aa. Equivalent to Rv0918, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 158 aa overlap). Conserved hypothetical protein, similar in part to Q50116 hypothetical protein from Mycobacterium leprae (44 aa), FASTA scores: opt: 132,E(): 0.0055, (65.6% identity in 32 aa overlap). Also some similarity in C-terminus with other hypothetical proteins e.g. NP_289961.1|NC_002655 hypothetical protein from Escherichia coli strain O157:H7 (94 aa); etc. Q7U112 No conserved hypotheticals Rv0918 NC_002945.3 Mycobrowser_v2 CDS 1025150 1025650 . + 0 Mb0943 gcn5-related n-acetyltransferase Mb0943, -, len: 166 aa. Equivalent to Rv0919, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 166 aa overlap). Conserved hypothetical protein, some similarity to Q50115 hypothetical protein from Mycobacterium leprae (90 aa), FASTA scores: opt: 243,E(): 5.3e-11, (56.5% identity in 85 aa overlap). Q7U111 No intermediary metabolism and respiration Rv0919 NC_002945.3 Mycobrowser_v2 tRNA 1025787 1025859 . - 0 argT argT tRNA-Arg argT, len: 73 nt. Equivalent to argT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon cct. No NC_002945.3 Mycobrowser_v2 CDS 1028151 1029803 . + 0 Mb0946 possible transposase Mb0946, -, len: 550 aa. Equivalent to Rv0922, len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 550 aa overlap). Possible transposase for IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa), FASTA scores: opt 939, E(): 0,(40.6% identity in 465 aa overlap); etc. Q7U108 No insertion seqs and phages Rv0922 NC_002945.3 Mycobrowser_v2 CDS 1029979 1031043 . - 0 Mb0947c CONSERVED HYPOTHETICAL PROTEIN Mb0947c, -, len: 354 aa. Equivalent to Rv0923c,len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Conserved hypothetical protein, showing similarity with C-terminal part of AF034138|AF034138_7|yjoB HYPOTHETICAL PROTEIN from Bacillus subtilis (200 aa), FASTA scores: opt: 193, E(): 4.2e-05, (32.3% identity in 167 aa overlap). Q7U107 No conserved hypotheticals Rv0923c NC_002945.3 Mycobrowser_v2 CDS 1031044 1033098 . - 0 Mb0948c mntH conserved protein Mb0948c, mntH, len: 685 aa. Similar to Rv0924c (mntH) and Rv0925c, len: 428 aa and 245 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 428 aa overlap and 93.2% identity in 237 aa overlap). mntH (alternative gene name: Nramp, Mramp), H+-dependent divalent cation-transport integral membrane protein (see citations below), equivalent to O69443|MNTH_MYCBO PROBABLE MANGANESE TRANSPORT PROTEIN MNTH (BRAMP) from Mycobacterium bovis (415 aa); and NP_302396.1|NC_002677 probable manganese transport protein from Mycobacterium leprae (426 aa). Also similar (but longer 51 aa in N-terminus) to AAA63075.1|U15184 SMF2 protein from Mycobacterium leprae (377 aa), FASTA scores: opt: 1780,E(): 0, (74.5% identity in 376 aa overlap). Also similar to many orthologues of the eukaryotic Nramp (natural resistance-associated macrophage protein), also known as mntH, e.g. NP_456951.1|NC_003198 manganese transport protein MntH from Salmonella enterica subsp. enterica serovar Typhi (413 aa); etc. BELONGS TO THE NRAMP FAMILY. And Conserved hypothetical protein, similar to AL132991|SCF55_19 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (197 aa), FASTA scores: opt: 459, E(): 1.2e-23,(39.3% identity in 201 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product. X2BG74,O69443 No NC_002945.3 Mycobrowser_v2 CDS 1033175 1034251 . - 0 Mb0949c CONSERVED HYPOTHETICAL PROTEIN Mb0949c, -, len: 358 aa. Equivalent to Rv0926c,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 358 aa overlap). Conserved hypothetical protein, similar to Rv1059 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (354 aa). Also shows some similarity to AF170923|AF170923_3 dihydrodipicolinate reductase from Mastigocladus laminosus (278 aa), FASTA scores: opt: 170, E(): 0.00088, (25.7% identity in 276 aa overlap). Q7U105 No conserved hypotheticals Rv0926c NC_002945.3 Mycobrowser_v2 CDS 1034305 1035096 . - 0 Mb0950c probable short-chain type dehydrogenase/reductase Mb0950c, -, len: 263 aa. Equivalent to Rv0927c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 263 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, notably 7-alpha-hydroxysteroid dehydrogenases and glucose 1-dehydrogenases e.g. P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 551,E(): 1e-26, (39.5% identity in 248 aa overlap); NP_252778.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa); etc. Also similar to other dehydrogenases from Mycobacterium tuberculosis e.g. MTCY09F9.36, E():1.4e-18; MTCY369.14, E():8e-17; MTCY02B10.14, E():2.5e-14; MTCY09F9.23c, E():1.5e-13; MTCY03C7.07, E():1.9e-13. Contains PS00061 Short-chain dehydrogenases/reductases family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U104 No intermediary metabolism and respiration Rv0927c NC_002945.3 Mycobrowser_v2 CDS 1035368 1036480 . + 0 Mb0951 pstS3 PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS3 (PBP-3) (PSTS3) (PHOS1) Mb0951, pstS3, len: 370 aa. Equivalent to Rv0928,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 370 aa overlap). pstS3 (previously known as phoS2), phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to others from Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1 phosphate-binding protein 3 precursor (328 aa), FASTA scores: opt: 1772, E(): 0,(79.6% identity in 328 aa overlap); and highly similar to others e.g. AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa). Also highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (370 aa); and Rv0934|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (374 aa) from Mycobacterium tuberculosis (Mycobacterium tuberculosis seems to have three PstS-like proteins,others being Rv0932c and Rv0934c). Contains lipoprotein signature (PS00013) at N-terminus. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. X2BGL4,P0A5Y3 No NC_002945.3 Mycobrowser_v2 CDS 1066517 1067884 . + 0 Mb0980 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0980, -, len: 455 aa. Equivalent to Rv0955, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 455 aa overlap). Probable conserved integral membrane protein, highly similar to AL035500|MLCL373_6 putative membrane protein from Mycobacterium leprae (430 aa), FASTA score: (75.9% identity in 419 aa overlap); and AAL05878.1|AF411607_2|AF411607 unknown protein from Mycobacterium avium subsp. paratuberculosis (409 aa). X2BGM3,P64772 No cell wall and cell processes Rv0955 NC_002945.3 Mycobrowser_v2 CDS 1036493 1037467 . + 0 Mb0952 pstC2 PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTC2 Mb0952, pstC2, len: 324 aa. Equivalent to Rv0929,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 324 aa overlap). pstC2,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_302394.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (319 aa); CAB88474.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (336 aa); NP_290359.1| NC_002655 high-affinity phosphate-specific transport system (cytoplasmic membrane component) from Escherichia coli strain O157:H7 (319 aa); etc. Also similar to Rv935|MTCY08D9.04c|PSTC1 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (338 aa). Contains binding-protein-dependent transport systems inner membrane component signature (PS00402). X2BGK2,P0A631 No NC_002945.3 Mycobrowser_v2 CDS 1037464 1038378 . + 0 Mb0953 pstA1 PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA1 Mb0953, pstA1, len: 304 aa. Equivalent to Rv0930,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Probable pstA1,phosphate-transport integral membrane ABC transporter (see citation below), highly similar to others e.g. NP_302393.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (304 aa); CAB88473.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (354 aa) (N-terminus longer); NP_312689.1|NC_002695 phosphate transport system permease protein PstA from Escherichia coli strain O157:H7 (296 aa); etc. Also similar to Rv0936|MTCY08D9.03c|PSTA2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa). Q7U103 No NC_002945.3 Mycobrowser_v2 CDS 1038385 1039494 . - 0 Mb0954c pknDb TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D PKNDb [SECOND PART](PROTEIN KINASE D) (STPK D) Mb0954c, pknDb, len: 369 aa. Equivalent to 3' end of Rv0931c, len: 664 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 369 aa overlap). pknD (alternate gene name: mbk), transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citations below),equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa); and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 aa). Also highly similar to others, particularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa); NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa); etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase subdomain. Contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb. Q7U102 No NC_002945.3 Mycobrowser_v2 CDS 1039505 1040380 . - 0 Mb0955c pknDa TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D PKNDa [FIRST PART] (PROTEIN KINASE D) (STPK D) Mb0955c, pknDa, len: 291 aa. Equivalent to 5' end of Rv0931c, len: 664 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 276 aa overlap). pknD (alternate gene name: mbk), transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citations below),equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa); and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 aa). Also highly similar to others, particularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa); NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa); etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase subdomain. Contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb. Q79IB8 No NC_002945.3 Mycobrowser_v2 CDS 1043766 1044782 . + 0 Mb0960 pstC1 PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTC1 Mb0960, pstC1, len: 338 aa. Equivalent to Rv0935,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 338 aa overlap). pstC1,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_104768.1|NC_002678|pstC phosphate ABC transporter permease protein from Mesorhizobium loti (327 aa); NP_245372.1|NC_002663|PstC PstC protein from Pasteurella multocida (320 aa); P45191|PSTC_HAEIN PHOSPHATE TRANSPORT SYSTEM PERMEASE from Haemophilus influenza (315 aa), FASTA scores: opt: 667, E(): 0, (36.2% identity in 309 aa overlap); etc. Also similar to Rv0929|MTCY21C12.23|PSTC2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (324 aa), FASTA scores: opt: 487, E(): 4.1e-21, (32.3% identity in 303 aa overlap); and shows slight similarity to MTCY08D9.03c|PSTA2|Rv0936 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402). X2BGK3,P0A629 No NC_002945.3 Mycobrowser_v2 CDS 1112835 1113911 . + 0 Mb1023 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb1023, -, len: 358 aa. Equivalent to Rv0996, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 358 aa overlap). Probable conserved transmembrane protein, equivalent to AL035500|MLCL373_25 putative membrane protein from Mycobacterium leprae (342 aa), FASTA scores: (66.4% identity in 360 aa overlap). Contains possible signal sequence and other hydrophobic domains. Q7U0W0 No cell wall and cell processes Rv0996 NC_002945.3 Mycobrowser_v2 CDS 1040402 1041514 . - 0 Mb0956c pstS2 PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS2 (PBP-2) (PSTS2) Mb0956c, pstS2, len: 370 aa. Equivalent to Rv0932c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 370 aa overlap). pstS2,phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa); Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa),FASTA scores: opt: 1601, E(): 0, (64.5% identity in 372 aa overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa) (M. tuberculosis seems to have three PstS-like proteins, others being Rv0928 and Rv0934c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 460, E(): 2.7e-20, (31.2% identity in 375 aa overlap). Contains prokaryotic membrane lipoprotein lipid attachment site (PS00013) at N-terminus so the leader peptide of 22 aa is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. Appears to be co-transcribed with Rv0931c|pknD|mbk. Q7U101 No NC_002945.3 Mycobrowser_v2 CDS 1041730 1041945 . + 0 Mb0957 pstBa PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBa [FIRST PART] Mb0957, pstBa, len: 71 aa. Equivalent to the 5' end of Rv0933, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv (98.4% identity in 64 aa overlap). pstB,phosphate-transport ATP-binding protein ABC transporter (see citations below), thermostable ATPase, highly similar to others e.g. NP_348334.1|NC_003030 ATPase component of ABC-type phosphate transport system from Clostridium acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate ABC transporter ATP-binding protein (pstB) from Borrelia burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC transporter (ATP-binding protein) from Bacillus subtilis (269 aa), FASTA scores: opt: 762, E(): 0, (47.7% identity in 243 aa overlap); etc. Also similar to other M. tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC transporters family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium seem to have no influence on the functionality of this enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pstB into 2 parts, pstBa and pstBb. Q7U100,Q7U0Z9 No NC_002945.3 Mycobrowser_v2 CDS 1041920 1042561 . + 0 Mb0958 pstBb PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBb [SECOND PART] Mb0958, pstBb, len: 213 aa. Equivalent to the 3' end of Rv0933, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 213 aa overlap). pstB, phosphate-transport ATP-binding protein ABC transporter (see citations below), thermostable ATPase, highly similar to others e.g. NP_348334.1|NC_003030 ATPase component of ABC-type phosphate transport system from Clostridium acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate ABC transporter ATP-binding protein (pstB) from Borrelia burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC transporter (ATP-binding protein) from Bacillus subtilis (269 aa),FASTA scores: opt: 762, E(): 0, (47.7% identity in 243 aa overlap); etc. Also similar to other M. tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC transporters family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium seem to have no influence on the functionality of this enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pstB into 2 parts,pstBa and pstBb. X2BG85,Q7U0Z9 No NC_002945.3 Mycobrowser_v2 CDS 1042582 1043706 . + 0 Mb0959 pstS1 PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS1 (PBP-1) (PSTS1) Mb0959, pstS1, len: 374 aa. Equivalent to Rv0934,len: 374 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 374 aa overlap). pstS1 (previously known as phoS1 or phoS), phosphate-binding lipoprotein component of inorganic phosphate transport system (see first, fourth, fifth and sixth citations below), highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA scores: opt: 460, E(): 5.9e-19, (31.2% identity in 375 aa overlap); and Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 435, E():1.1e-17, (30.0% identity in 380 aa overlap) (Mycobacterium tuberculosis seems to have three PstS-like proteins, others being Rv0932c and Rv0928c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 2459, E(): 0, (100% identity in 374 aa overlap). Contains a prokaryotic membrane lipoprotein lipid attachment site (PS00013) at the N-terminus so the 23 aa leader peptide sequence is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. Q7U0Z8 No NC_002945.3 Mycobrowser_v2 CDS 1052011 1052784 . - 0 Mb0966c CONSERVED HYPOTHETICAL PROTEIN Mb0966c, -, len: 257 aa. Equivalent to Rv0941c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Conserved hypothetical protein, showing some similarity with parts of several hypothetical proteins from Streptomyces coelicolor e.g. AL035161|SC9C7_20 (860 aa), FASTA scores: opt: 197, E(): 2.6e-05, (34.2% identity in 114 aa overlap). Q7U0Z5 No conserved hypotheticals Rv0941c NC_002945.3 Mycobrowser_v2 CDS 1044784 1045689 . + 0 Mb0961 pstA2 PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA2 Mb0961, pstA2, len: 301 aa. Equivalent to Rv0936,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). pstA2,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_442269.1|NC_000911|PstA phosphate transport system permease protein from Synechocystis sp. strain PCC 6803 (287 aa); NP_232473.1|NC_002506 phosphate ABC transporter permease protein from Vibrio cholerae (289 aa); P07654|PSTA_ECOLI PHOSPHATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (296 aa), FASTA scores: opt: 464, E(): 6.7e-24, (30.5% identity in 282 aa overlap); etc. Also similar to O86345|MTCY21C12.24|PSTA1|Rv0930 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (304 aa),FASTA scores: opt: 369, E(): 6.1e-15, (32.7% identity in 248 aa overlap). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402). X2BGM5,P0A627 No NC_002945.3 Mycobrowser_v2 CDS 1045666 1046487 . - 0 Mb0962c mku dna end-binding protein, mku Mb0962c, -, len: 273 aa. Equivalent to Rv0937c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Conserved hypothetical protein, highly similar to others e.g. SC6G9.24c|T35620|AL079356 hypothetical protein from Streptomyces coelicolor (365 aa), FASTA scores: opt: 648,E(): 0, (36.5% identity in 274 aa overlap); Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical proteins from Bacillus subtilis (311 aa), FASTA scores: opt: 623, E(): 1.1e-31, (33.9% identity in 274 aa overlap); O28548|AE000984|AF1726|NP_070554.1|NC_000917 conserved hypothetical protein from Archaeoglobus fulgidus (286 aa), FASTA scores: opt: 583, E(): 0, (36.6% identity in 262 aa overlap); etc. Q7U0Z7 No information pathways Rv0937c NC_002945.3 Mycobrowser_v2 CDS 1046603 1048882 . + 0 Mb0963 ligd atp dependent dna ligase ligd (atp dependent polydeoxyribonucleotide synthase) (thermostable dna ligase) (atp dependent polynucleotide ligase) (sealase) (dna repair enzyme) (dna joinase) Mb0963, -, len: 759 aa. Equivalent to Rv0938, len: 759 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 759 aa overlap). Possible ATP-dependent DNA ligase (EC 6.5.1.1), with its C-terminus similar to N-terminal parts of many ATP-dependent DNA ligases e.g. NP_250828.1|NC_002516 probable ATP-dependent DNA ligase from Pseudomonas aeruginosa (840 aa); NP_105436.1|NC_002678 ATP-dependent DNA ligase from Mesorhizobium loti (829 aa); CAB92891.1|AL356932 probable ATP-dependent DNA ligase from Streptomyces coelicolor (326 aa); etc. The N-terminal half shows similarity with hypothetical proteins from Mycobacterium tuberculosis Rv0269c and Rv3730c; and the C-terminal half with the DNA ligases Rv3731 and Rv3062. X2BG90,P59971 No information pathways Rv0938 NC_002945.3 Mycobrowser_v2 CDS 1048879 1050813 . + 0 Mb0964 POSSIBLE BIFUNCTIONAL ENZYME: 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE) + CYCLASE/DEHYDRASE Mb0964, -, len: 644 aa. Equivalent to Rv0939, len: 644 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 644 aa overlap). Possible bifunctional enzyme, including 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase activity (EC 5.3.3.-), and cyclase/dehydrase activity (EC undetermined). N-terminal part similar to many isomerases e.g. NP_343861.1|NC_002754 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Sulfolobus solfataricus (318 aa); NP_068932.1|NC_000917 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Archaeoglobus fulgidus (324 aa),FASTA scores: opt: 400, E(): 5.8e-15, (33.9% identity in 289 aa overlap); etc. And C-terminal part highly similar to many cyclases/dehydrases e.g. AAK61721.1|AY033994 cyclase-like protein from Streptomyces aureofaciens (305 aa); CAC44204.1|AL593842 cyclase from Streptomyces coelicolor (297 aa), FASTA scores: opt: 375, E(): 2.7e-26,(35.6% identity in 284 aa overlap); NP_343860.1|NC_002754 putative Cyclase/dehydrase from Sulfolobus solfataricus (308 aa); etc. Also similar to Rv2993c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. Q7U0Z6 No intermediary metabolism and respiration Rv0939 NC_002945.3 Mycobrowser_v2 tRNA 1113962 1114034 . + 0 alaV alaV tRNA-Ala alaV, len: 73 nt. Equivalent to alaV, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon cgc. No NC_002945.3 Mycobrowser_v2 CDS 1051060 1051926 . - 0 Mb0965c POSSIBLE OXIDOREDUCTASE Mb0965c, -, len: 288 aa. Equivalent to Rv0940c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 288 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); AAG52987.1|AF040570|Rif17 putative alkanal monooxygenase from Amycolatopsis mediterranei (356 aa); etc. Also similar to putative oxidoreductases from Mycobacterium tuberculosis such as Rv0953c|P71557|YT21_MYCTU (282 aa), FASTA scores: opt: 311, E(): 3.7e-08, (31.0% identity in 248 aa overlap),Rv3079c (275 aa), Rv0791c (347 aa), etc. X2BGL1,P64762 No intermediary metabolism and respiration Rv0940c NC_002945.3 Mycobrowser_v2 CDS 1053163 1054203 . - 0 Mb0968c PROBABLE MONOOXYGENASE Mb0968c, -, len: 346 aa. Equivalent to Rv0943c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 346 aa overlap). Possible monooxygenase (EC 1.-.-.-), similar in part to others e.g. NP_250229.1|NC_002516 probable flavin-containing monooxygenase from Pseudomonas aeruginosa (527 aa); AAC36351.1|AF090329 cyclohexanone monooxygenase homolog from Pseudomonas fluorescens (437 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); etc. Also similar to putative monooxygenases from Mycobacterium tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa). FASTA scores: opt: 129, E(): 8.5e-21, (27.5% identity in 236 aa overlap); Rv0892 (495 aa); Rv3049c (524 aa); etc. X2BG95 No intermediary metabolism and respiration Rv0943c NC_002945.3 Mycobrowser_v2 CDS 1054232 1054708 . + 0 Mb0969 POSSIBLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FAPY-DNA GLYCOSYLASE) Mb0969, -, len: 158 aa. Equivalent to Rv0944, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 158 aa overlap). Possible formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), similar to C-terminus of formamidopyrimidine-DNA glycosylases e.g. CAB63194.1|AL133469 putative formamidopyrimidine-DNA glycosylase from Streptomyces coelicolor (287 aa); FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) from Lactococcus lactis subsp. lactis (273 aa), FASTA scores: opt: 246, E(): 2.4e-09,(28.9% identity in 142 aa overlap); O50606|FPG_THETH|MUTM|FPG FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Thermus thermophilus (267 aa); etc. Also similar to C-termini of endonucleases or DNA glycosylases of Mycobacterium tuberculosis e.g. Rv3297, Rv2464c,Rv2924c. MAY BE BELONG TO THE FPG FAMILY. Q7U0Z4 No information pathways Rv0944 NC_002945.3 Mycobrowser_v2 CDS 1054714 1055475 . + 0 Mb0970 probable short-chain type dehydrogenase/reductase Mb0970, -, len: 253 aa. Equivalent to Rv0945, len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 253 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_346338.1|NC_003028 oxidoreductase (short chain dehydrogenase/reductase family) from Streptococcus pneumoniae (253 aa); AAB70845.1|AF019986|PksB from Dictyostelium discoideum (260 aa); AAF86624.1|U87786 clavaldehyde dehydrogenase from Streptomyces clavuligerus (247 aa); P37440|UCPA_ECOLI oxidoreductase from Escherichia coli (285 aa), FASTA scores: opt: 275, E(): 1.1e-12, (33.8% identity in 201 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U0Z3 No intermediary metabolism and respiration Rv0945 NC_002945.3 Mycobrowser_v2 CDS 1068000 1068647 . + 0 Mb0981 purN PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN (GART) (GAR TRANSFORMYLASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE) Mb0981, purN, len: 215 aa. Equivalent to Rv0956,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Probable purN,5'-phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), equivalent to AAF05726.1|AF191543_1|AF191543|PurN phosphoribosylglycinamide formyltransferase from Mycobacterium avium subsp. paratuberculosis (209 aa); and AL035500|MLCL373_7 from Mycobacterium leprae (215 aa),FASTA score: (79.4% identity in 214 aa overlap). Also highly similar to others e.g. BAA89443.1|AB003159 from Corynebacterium ammoniagenes (199 aa); NP_241498.1|NC_002570 from Bacillus halodurans (188 aa); P08179|PUR3_ECOLI|B2500 from Escherichia coli strain K12 (212 aa), FASTA scores: opt: 380, E(): 2.4e-18, (36.6% identity in 183 aa overlap); C-terminus of P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 from Drosophila pseudoobscura (Fruit fly) (1364 aa); etc. Q7U0Y9 No intermediary metabolism and respiration Rv0956 NC_002945.3 Mycobrowser_v2 CDS 1055491 1057152 . - 0 Mb0971c pgi PROBABLE GLUCOSE-6-PHOSPHATE ISOMERASE PGI (GPI) (PHOSPHOGLUCOSE ISOMERASE) (PHOSPHOHEXOSE ISOMERASE) (PHI) Mb0971c, pgi, len: 553 aa. Equivalent to Rv0946c,len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 553 aa overlap). Probable pgi,glucose-6-phosphate isomerase (EC 5.3.1.9), equivalent to NP_301236.1|NC_002677 glucose-6-phosphate isomerase from Mycobacterium leprae (554 aa); and P96803|G6PI_MYCSM GLUCOSE-6-PHOSPHATE ISOMERASE from Mycobacterium smegmatis (442 aa). Also highly similar to others e.g. T36015 glucose-6-phosphate isomerase from Streptomyces coelicolor (551 aa); P11537|G6PI_ECOLI|GPI glucose-6-phosphate isomerase from Escherichia coli strains K12 and O157:H7 (549 aa), FASTA scores: opt: 1779, E(): 0, (51.4% identity in 554 aa overlap); etc. Contains PS00765 Phosphoglucose isomerase signature 1, and PS00174 Phosphoglucose isomerase signature 2. BELONGS TO THE GPI FAMILY. X2BGN2,P64193 No NC_002945.3 Mycobrowser_v2 CDS 1057767 1057997 . - 0 Mb0972c probable mycolyl transferase, pseudogene Mb0972c, -, len: 76 aa. Equivalent to Rv0947c, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 76 aa overlap). Probable mycolyl transferase pseudogene (EC 2.-.-.-), similar to part of P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c) (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 213, E(): 2e-08,(69.6% identity in 46 aa overlap). No lipid metabolism Rv0947c NC_002945.3 Mycobrowser_v2 CDS 1065566 1066477 . + 0 Mb0979 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0979, -, len: 303 aa. Equivalent to Rv0954, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 303 aa overlap). Probable conserved transmembrane protein, highly similar to 34KD_MYCPA|Q04959 34 kd antigenic protein from Mycobacterium paratuberculosis (298 aa), FASTA scores: opt: 1023, E(): 7.2e-36, (59.3% identity in 305 aa overlap); AAC69251.1|U82111 34 kDa antigen precursor from Mycobacterium leprae (336 aa); and AL035500|MLCL373.06 hypothetical membrane protein from Mycobacterium leprae (297 aa), FASTA score: (55.6% identity in 315 aa overlap). X2BGJ1,P65638 No cell wall and cell processes Rv0954 NC_002945.3 Mycobrowser_v2 CDS 1058727 1061042 . + 0 Mb0974 uvrD1 probable atp-dependent dna helicase ii uvrd1 Mb0974, uvrD1, len: 771 aa. Equivalent to Rv0949,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 771 aa overlap). Probable uvrD1, ATP dependent DNA helicase (EC 3.6.1.-), equivalent to P_301239.1|NC_002677 putative ATP-dependent DNA helicase from Mycobacterium leprae (778 aa). Also highly similar to others e.g. CAB92660.1|AL356832 from Streptomyces coelicolor (831 aa) (N-terminus longer); P56255|PCRA_BACST from Bacillus stearothermophilus (724 aa); Q10213|YAY5_SCHPO from Schizosaccharomyces pombe (Fission yeast) (887 aa), FASTA scores: opt: 927, E(): 0, (33.5% identity in 659 aa overlap); etc. Also similar to several other UvrD-like proteins in Mycobacterium tuberculosis e.g. Rv3201c, Rv3198c, Rv3202c. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. Note that previously known as uvrD. X2BGI2,P0A5A4 No NC_002945.3 Mycobrowser_v2 CDS 1068644 1070215 . + 0 Mb0982 purH PROBABLE BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH: PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE (AICAR TRANSFORMYLASE) (5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE-4-CARBOXAMIDE FORMYLTRANSFERASE) + INOSINEMONOPHOSPHATE CYCLOHYDROLASE (IMP CYCLOHYDROLASE) (INOSINICASE) (IMP SYNTHETASE) (ATIC) Mb0982, purH, len: 523 aa. Equivalent to Rv0957,len: 523 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 523 aa overlap). Probable purH,bifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase (EC 2.1.2.3) and inosine-monophosphate (IMP) cyclohydrolase (EC 3.5.4.10), equivalent to AL035500|MLCL373_8 putative phosphoribosylaminoimidazolecarboxamide formyltransferase from Mycobacterium leprae (527 aa), FASTA score: (88.1% identity in 520 aa overlap); and AF05727.1|AF191543_2|AF191543|PurH from Mycobacterium avium subsp. paratuberculosis (527 aa). Also highly similar to others e.g. CAB92677.1|AL356832 bifunctional purine biosynthesis protein from Streptomyces coelicolor (523 aa); NP_388534.1|NC_000964 phosphoribosylaminoimidazole carboxy formyl formyltransferase + inosine-monophosphate cyclohydrolase from Bacillus subtilis (512 aa); P15639|PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase from Escherichia coli (529 aa), FASTA scores: opt: 1147,E(): 0, (44.8% identity in 533 aa overlap); etc. BELONGS TO THE PURH FAMILY. X2BGN4,P67542 No intermediary metabolism and respiration Rv0957 NC_002945.3 Mycobrowser_v2 CDS 1061123 1062121 . - 0 Mb0975c CONSERVED HYPOTHETICAL PROTEIN Mb0975c, -, len: 332 aa. Equivalent to Rv0950c,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 332 aa overlap). Conserved hypothetical protein, highly similar to AL035500|MLCL373.02c|T45433 hypothetical protein from Mycobacterium leprae (343 aa),FASTA scores: opt: 1500, E(): 0, (71.0% identity in 331 aa overlap). C-terminus highly similar to part of various proteins e.g. C-terminal part of NP_441943.1|NC_000911|NlpD lipoprotein from Synechocystis sp (715 aa); N-terminal part of NP_066789.1|NC_002576 putative peptidase from Rhodococcus equi (546 aa); C-terminal part of NP_212396.1|NC_001318 conserved hypothetical protein from Borrelia burgdorferi (417 aa); C-terminal part of P33648|NLPD_ECOLI|nlpd lipoprotein from Escherichia coli (379 aa), FASTA scores: opt: 276, E(): 2e-10, (29.9% identity in 234 aa overlap); etc. Q7U0Z2 No conserved hypotheticals Rv0950c NC_002945.3 Mycobrowser_v2 CDS 1062431 1063594 . + 0 Mb0976 sucC PROBABLE SUCCINYL-COA SYNTHETASE (BETA CHAIN) SUCC (SCS-BETA) Mb0976, sucC, len: 387 aa. Equivalent to Rv0951,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Probable sucC,succinyl-Coa synthetase, beta chain (EC 6.2.1.5),equivalent to AL035500|MLCL373_3|NP_301241.1|NC_002677 succinyl-CoA synthase [beta] chain from Mycobacterium leprae (393 aa), FASTA score: (86.7% identity in 391 aa overlap). Also highly similar to others e.g. AB92671.1|AL356832 succinyl-CoA synthetase beta chain from Streptomyces coelicolor (394 aa); P25126|SUCC_THEFL SUCCINYL-COA SYNTHETASE BETA CHAIN from Thermus aquaticus (378 aa); P07460|SUCC_ECOLI succinyl-CoA synthetase beta chain from Escherichia coli (388 aa), FASTA scores: opt: 933, E(): 0, (41.0% identity in 390 aa overlap); etc. X2BGN9,Q7U0Z1 No intermediary metabolism and respiration Rv0951 NC_002945.3 Mycobrowser_v2 CDS 1187883 1188449 . + 0 Mb1094 CONSERVED HYPOTHETICAL PROTEIN Mb1094, -, len: 188 aa. Equivalent to Rv1065, len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 188 aa overlap). Conserved hypothetical protein, some similarity to AL0209|SC4H8_11 hypothetical protein from Streptomyces coelicolor (182 aa), FASTA scores: opt: 156, E(): 0.0011, (31.3% identity in 195 aa overlap). Q7U0R3 No conserved hypotheticals Rv1065 NC_002945.3 Mycobrowser_v2 CDS 1063607 1064518 . + 0 Mb0977 sucD PROBABLE SUCCINYL-COA SYNTHETASE (ALPHA CHAIN) SUCD (SCS-ALPHA) Mb0977, sucD, len: 303 aa. Equivalent to Rv0952,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Probable sucD,succinyl-CoA synthetase, alpha chain (EC 6.2.1.5),equivalent to AL035500|MLCL373_4|NP_301242.1|NC_002677 succinyl-CoA synthase [alpha] chain from Mycobacterium leprae (300 aa), FASTA score: (86.3% identity in 300 aa overlap). Also highly similar to others e.g. CAB92672.1|AL356832 from Streptomyces coelicolor (294 aa); P53591|SUCD_COXBU from Escherichia coli (288 aa), FASTA scores: opt: 855, E(): 0, (53.8% identity in 286 aa overlap); etc. Contains PS00399 ATP-citrate lyase and succinyl-CoA ligases active site, and PS00017 ATP/GTP-binding site motif A (P-loop). X2BGN0,Q7U0Z0 No intermediary metabolism and respiration Rv0952 NC_002945.3 Mycobrowser_v2 CDS 1064553 1065401 . - 0 Mb0978c POSSIBLE OXIDOREDUCTASE Mb0978c, -, len: 282 aa. Equivalent to Rv0953c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 282 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to CAA48222.1|X68102 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (166 aa). Similar to several hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); NP_070025.1|NC_000917 N5,N10-methylenetetrahydromethanopterin reductase (mer-2) from Archaeoglobus fulgidus (348 aa); etc. Also similar to several hypothetical proteins and oxidoreductases from Mycobacterium tuberculosis e.g. Rv2161c|O06216|Z95388|MTCY270.07 (288 aa), FASTA scores: opt: 633, E(): 0, (40.4% identity in 277 aa overlap),Rv3079c (275 aa), Rv0791c (347 aa), etc. Contains PS00201 Flavodoxin signature. X2BGA8,P64770 No intermediary metabolism and respiration Rv0953c NC_002945.3 Mycobrowser_v2 CDS 1107894 1108550 . - 0 Mb1017c HYPOTHETICAL PROTEIN Mb1017c, -, len: 218 aa. Equivalent to Rv0990c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Hypothetical unknown protein. Q7U0W6 No conserved hypotheticals Rv0990c NC_002945.3 Mycobrowser_v2 CDS 1070322 1071701 . + 0 Mb0983 POSSIBLE MAGNESIUM CHELATASE Mb0983, -, len: 459 aa. Equivalent to Rv0958, len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 459 aa overlap). Possible magnesium chelatase (EC 4.99.1.-), similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148,E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA MAGNESIUM-CHELATASE SUBUNIT CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase (EC 4.99.1.-) chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) Q7U0Y8 No intermediary metabolism and respiration Rv0958 NC_002945.3 Mycobrowser_v2 CDS 1071694 1073712 . + 0 Mb0984 CONSERVED HYPOTHETICAL PROTEIN Mb0984, -, len: 672 aa. Equivalent to Rv0959, len: 672 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 672 aa overlap). Conserved hypothetical protein, similar to AE002069|AE002069_12 hypothetical protein from Deinococcus radiodurans (403 aa), FASTA scores: opt: 395, E(): 1.3e-15, (26.8% identity in 426 aa overlap). Contains a single copy at the N-terminus of a short repeat found three times in the M. tuberculosis ORF O33341|MTV003.05c|AL008883. X2BGJ9 No conserved hypotheticals Rv0959 NC_002945.3 Mycobrowser_v2 CDS 1073766 1073987 . + 0 Mb0984A vapB9 Possible antitoxin VapB9 Mb0984A, len: 73 aa. Equivalent to Rv0959A len: 73 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB9,antitoxin, part of toxin-antitoxin (TA) operon with Rv0960 (See Arcus et al., 2005; Pandey and Gerdes, 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv1721c X2BGM8 No virulence, detoxification, adaptation Rv0959A NC_002945.3 Mycobrowser_v2 CDS 1073984 1074367 . + 0 Mb0985 vapc9 possible toxin vapc9 Mb0985, -, len: 127 aa. Equivalent to Rv0960, len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 127 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv0065|MTV030.08 (133 aa),FASTA scores: E(): 1.5e-14, (38.3% identity in 128 aa overlap), Rv1720c (129 aa), and Rv0549c (137 aa). X2BGP9,P64774 No virulence, detoxification, adaptation Rv0960 NC_002945.3 Mycobrowser_v2 CDS 1074513 1074860 . + 0 Mb0986 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb0986, -, len: 115 aa. Equivalent to Rv0961, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Probable integral membrane protein. X2BGN7,P64776 No cell wall and cell processes Rv0961 NC_002945.3 Mycobrowser_v2 CDS 1074879 1075553 . - 0 Mb0987c lprP POSSIBLE LIPOPROTEIN LPRP Mb0987c, lprP, len: 224 aa. Equivalent to Rv0962c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Possible lprP,lipoprotein. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. X2BGC0,P59987 No NC_002945.3 Mycobrowser_v2 CDS 1075736 1076536 . - 0 Mb0988c CONSERVED HYPOTHETICAL PROTEIN Mb0988c, -, len: 266 aa. Equivalent to Rv0963c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 266 aa overlap). Conserved hypothetical protein, similar in part to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: E(): 1.2e-23,(39.0% identity in 254 aa overlap); Rv2542 (403 aa); Rv2079 (656 aa). Also similar in part to AL133423|SC4A7_3 HYPOTHETICAL SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FASTA scores: opt: 231, E(): 6.8e-07, (31.4% identity in 204 aa overlap); and SCH10.21c|T36533 hypothetical protein from Streptomyces coelicolor (329 aa). X2BGL0 No conserved hypotheticals Rv0963c NC_002945.3 Mycobrowser_v2 CDS 1077217 1077636 . - 0 Mb0990c CONSERVED HYPOTHETICAL PROTEIN Mb0990c, -, len: 139 aa. Equivalent to Rv0965c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 139 aa overlap). Conserved hypothetical protein, showing weak similarity with Rv2798c|MTCY16B7.45 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (108 aa), FASTA scores: E(): 5.6e-12, (38.9% identity in 90 aa overlap). Equivalent to AAK45242.1 from Mycobacterium tuberculosis strain CDC1551 (146 aa) but shorter 7 aa. Q7U0Y7 No conserved hypotheticals Rv0965c NC_002945.3 Mycobrowser_v2 CDS 1077672 1078274 . - 0 Mb0991c conserved protein Mb0991c, -, len: 200 aa. Equivalent to Rv0966c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 200 aa overlap). Conserved hypothetical protein, equivalent to AL035500|MLCL373_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (200 aa),FASTA scores: opt: 1080, E(): 0, (79.5% identity in 200 aa overlap). Also highly similar to SCE6.30c|CAB88834.1|AL353832 hypothetical protein from Streptomyces coelicolor (277 aa). Some similarity to Rv2862c|MTV007.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (194 aa), FASTA scores: E(): 3.1e-06, (31.5% identity in 184 aa overlap). Equivalent to AAK45243.1 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 30 aa. Note that Rv0966c has been shortened since first entry. Q7U0Y6 No conserved hypotheticals Rv0966c NC_002945.3 Mycobrowser_v2 CDS 1078414 1078773 . + 0 Mb0992 csor copper-sensitive operon repressor csor Mb0992, -, len: 119 aa. Equivalent to Rv0967, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 119 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. AE002074|AE002074_11 from Deinococcus radiodurans (102 aa), FASTA scores: opt: 233, E(): 8.6e-10, (47.0% identity in 83 aa overlap); O32222|Z99121|YVGZ from Bacillus subtilis (101 aa), FASTA scores: opt:228, E(): 3.2e-15, (38.0% identity in 92 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0190, and Rv1766. X2BGF2,Q7U0Y5 No regulatory proteins Rv0967 NC_002945.3 Mycobrowser_v2 CDS 1114312 1114563 . + 0 Mb1023A HYPOTHETICAL PROTEIN Mb1023A, -, len: 83 aa. Equivalent to hypothetical protein MT1025.2 from Mycobacterium tuberculosis strain CDC1551, (100% identity with 83 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al.,2013). Mb1023A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BGU3 No NC_002945.3 Mycobrowser_v2 CDS 1079182 1081494 . + 0 Mb0994 ctpV PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE CTPV Mb0994, ctpV, len: 770 aa. Equivalent to Rv0969,len: 770 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 770 aa overlap). Probable ctpV, metal cation transporter P-type ATPase (transmembrane protein) (EC 3.6.3.-), highly similar (except in N-terminus) to others e.g. NP_391230.1|NC_000964 similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); P37279|ATCS_SYNP7|PACS cation-transporting ATPase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (747 aa), FASTA scores: opt: 1851, E(): 0, (52.1% identity in 664 aa overlap); etc. Equivalent to AAK45246.1 from Mycobacterium tuberculosis strain CDC1551 (792 aa) but shorter 22 aa. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). Q7U0Y4 No cell wall and cell processes Rv0969 NC_002945.3 Mycobrowser_v2 CDS 1081491 1082123 . + 0 Mb0995 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0995, -, len: 210 aa. Equivalent to Rv0970, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Probable conserved integral membrane protein, equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). X2BGU9,P64782 No cell wall and cell processes Rv0970 NC_002945.3 Mycobrowser_v2 CDS 1082214 1083023 . - 0 Mb0996c echA7 PROBABLE ENOYL-COA HYDRATASE ECHA7 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0996c, echA7, len: 269 aa. Equivalent to Rv0971c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 269 aa overlap). Probable echA7,enoyl-CoA hydratase (EC 4.2.1.17), similar to many e.g. CAB95895.1|AL359988 putative enoyl CoA hydratase from Streptomyces coelicolor (247 aa); P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (257 aa),FASTA scores: opt: 369, E(): 2.6e-15, (33.7% identity in 246 aa overlap); etc. Q7U0Y3 No NC_002945.3 Mycobrowser_v2 CDS 1083023 1084189 . - 0 Mb0997c fadE12 acyl-coa dehydrogenase fade12 Mb0997c, fadE12, len: 388 aa. Equivalent to Rv0972c, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 388 aa overlap). Probable fadE12, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB95893.1|AL359988 putative acyl CoA dehydrogenase from Streptomyces coelicolor (382 aa); P45857|ACDB_BACSU from Bacillus subtilis (379 aa), FASTA scores: opt: 576, E(): 2.3e-26, (29.7% identity in 381 aa overlap); etc. X2BGF7,Q7U0Y2 No lipid metabolism Rv0972c NC_002945.3 Mycobrowser_v2 CDS 1084186 1086189 . - 0 Mb0998c accA2 PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) ACCA2: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP) Mb0998c, accA2, len: 667 aa. Equivalent to Rv0973c,len: 667 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 667 aa overlap). Probable accA2 (alternate gene name: bccA), acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)],highly similar to others e.g. CAB95892.1|AL359988 putative acetyl/propionyl CoA carboxylase alpha subunit from Streptomyces coelicolor (614 aa); NP_250702.1|NC_002516 probable acyl-CoA carboxylase alpha chain from Pseudomonas aeruginosa (655 aa); NP_420971.1|NC_002696 acetyl/propionyl-CoA carboxylase alpha subunit from Caulobacter crescentus ( 654 aa); NP_251581.1|NC_002516 probable biotin carboxylase/biotin carboxyl carrier protein from Pseudomonas aeruginosa (661 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) (654 aa), FASTA scores, opt: 250, E(): 4e-09, (28.6% identity in 182 aa overlap); and Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127 aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in 500 aa overlap). Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site. Q7U0Y1 No NC_002945.3 Mycobrowser_v2 CDS 1086195 1087784 . - 0 Mb0999c accD2 PROBABLE ACETYL-/PROPIONYL-COA CARBOXYLASE (BETA SUBUNIT) ACCD2 Mb0999c, accD2, len: 529 aa. Equivalent to Rv0974c,len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 529 aa overlap). Probable accD2,acetyl-/propionyl-CoA carboxylase (beta subunit) (EC 6.4.1.-), highly similar to many e.g. CAB95891.1|AL35998 putative acetyl/propionyl CoA carboxylase beta subunit from Streptomyces coelicolor (532 aa); NP_250704.1|NC_002516 probable acyl-CoA carboxyltransferase beta chain from Pseudomonas aeruginosa (535 aa); BAB16296.1|AB039884 acetyl-CoA carboxylase carboxyltransferase from Myxococcus xanthus (538 aa); NP_420973.1|NC_002696 putative propionyl-CoA carboxylase beta subunit from Caulobacter crescentus (530 aa); etc. Also similar to other from Mycobacterium tuberculosis: Rv2502c|ACCD1, Rv3799c|ACCD4, etc. COULD BELONG TO THE ACCD/PCCB FAMILY. Q7U0Y0 No NC_002945.3 Mycobrowser_v2 CDS 1087825 1088934 . - 0 Mb1000c fadE13 PROBABLE ACYL-COA DEHYDROGENASE FADE13 Mb1000c, fadE13, len: 369 aa. Equivalent to the 5' end of Rv0975c, len: 382 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 349 aa overlap). Probable fadE13, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. T35427 probable acyl-CoA dehydrogenase from Streptomyces coelicolor (382 aa); M74096|HUMACADL_1 Human long chain acyl-CoA dehydrogenase from Homo sapiens (430 aa), FASTA scores: opt: 819, E(): 0, (37.0% identity in 376 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa), FASTA scores: (40.3% identity in 375 aa overlap). Contains PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U0X9 No NC_002945.3 Mycobrowser_v2 CDS 1088931 1090613 . - 0 Mb1001c CONSERVED HYPOTHETICAL PROTEIN Mb1001c, -, len: 560 aa. Equivalent to Rv0976c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 560 aa overlap). Conserved hypothetical protein, highly similar to others e.g. CAB95890.1|AL359988 conserved hypothetical protein from Streptomyces coelicolor (558 aa); P_251576.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (600 aa); etc. N-terminal part highly similar to AL035500|MLCL373_14 probable pseudogene from Mycobacterium leprae (163 aa),FASTA score: (50.0% identity in 122 aa overlap). Q7TVC1 No conserved hypotheticals Rv0976c NC_002945.3 Mycobrowser_v2 CDS 1216898 1217002 . + 0 Mb1119 celA2a PROBABLE CELLULASE CELA2A (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE) Mb1119, celA2a, len: 34 aa. Equivalent to Rv1089A,len: 34 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 34 aa overlap). Probable celA2a, first part of cellulase (endoglucanase) (EC 3.2.1.4), similar to N-terminus of others. Q7U0P3 No NC_002945.3 Mycobrowser_v2 CDS 1097273 1097959 . + 0 Mb1007 mprA Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) Mb1007, len: 228 aa. Equivalent to Rv0981 len: 228 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 228 aa overlap). MprA,mycobacterial persistence regulator, a two-component response regulator whose expression is required for entrance into and maintenance of persistent infection (see citation below),equivalent to NP_301250.1|NC_002677 putative two-component response regulator from Mycobacterium leprae (228 aa); and highly similar to others from Mycobacterium leprae. Also highly similar to others e.g. AAG36759.1|AF119221_1|AF119221 response regulator from Corynebacterium glutamicum (232 aa); CAB88489.1|AL353816 putative two-component system response regulator from Streptomyces coelicolor (248 aa); BJY09666_1 two-component response regulator (ragA, ragB and rpoH3) from B.japonicum (226 aa), FASTA score: (43.8% identity in 224 aa overlap); BSAJ2571_44 two-component response regulator from Bacillus subtilis (228 aa), FASTA score: (46.4% identity in 224 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv1033c (257 aa); Rv0903c (236 aa), FASTA score: (50.7 identity in 225 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2. Start changed since first submission (-2 aa). MprAB is involved in the regulation of genes in response to environmental stress (See He et al., 2006). X2BGG7,Q7U0X4 No regulatory proteins Rv0981 NC_002945.3 Mycobrowser_v2 CDS 1090812 1093583 . + 0 Mb1002 PE_PGRS16 pe-pgrs family protein pe_pgrs16 Mb1002, PE_PGRS16, len: 923 aa. Equivalent to Rv0977, len: 923 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 923 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to other PGRS-type sequences e.g. AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa), FASTA score: (45.4% identity in 959 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FASTA score: (51.5% identity in 750 aa overlap); etc. Q7U0X8 No NC_002945.3 Mycobrowser_v2 CDS 1093800 1094807 . - 0 Mb1003c PE_PGRS17 pe-pgrs family protein pe_pgrs17 Mb1003c, PE_PGRS17, len: 335 aa. Similar to Rv0978c, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv, (93.7% identity in 335 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (73.6% identity in 277 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 115 bp to 127 bp substitution leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331 aa). Q7U0X7 No NC_002945.3 Mycobrowser_v2 CDS 1095121 1095315 . - 0 Mb1004c HYPOTHETICAL PROTEIN Mb1004c, -, len: 64 aa. Equivalent to Rv0979c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 64 aa overlap). Hypothetical unknown protein. Start codon changed since first submission (-44 aa) Q7U0X6 No conserved hypotheticals Rv0979c NC_002945.3 Mycobrowser_v2 CDS 1095337 1095510 . + 0 Mb1005 rpmF 50s ribosomal protein l32 rpmf Mb1005, rpmF, len: 57 aa. Equivalent to Rv0979A,len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 57 aa overlap). Probable rpmF, 50S ribosomal protein L32, similar to others e.g. rpmF|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN from Streptomyces coelicolor (56 aa), FASTA scores: E(): 5.1e-09, (63.45% identity in 52 aa overlap); etc. BELONGS TO THE L32P FAMILY OF RIBOSOMAL PROTEINS. X2BGV8,P0A5V9 No information pathways Rv0979A NC_002945.3 Mycobrowser_v2 CDS 1095529 1096902 . - 0 Mb1006c PE_PGRS18 pe-pgrs family protein pe_pgrs18 Mb1006c, PE_PGRS18, len: 457 aa. Equivalent to Rv0980c, len: 457 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 457 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (66.7% identity in 405 aa overlap); Z95844|MTCY493_2 from Mycobacterium tuberculosis (741 aa),FASTA score: (53.0% identity in 394 aa overlap); etc. Q7U0X5 No NC_002945.3 Mycobrowser_v2 CDS 1114744 1115175 . + 0 Mb1024 HYPOTHETICAL PROTEIN Mb1024, -, len: 143 aa. Equivalent to Rv0997, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 143 aa overlap). Hypothetical unknown protein, equivalent to AAK45276.1 from Mycobacterium tuberculosis strain CDC1551 (87 aa) but longer 56 aa. Q7U0V9 No conserved hypotheticals Rv0997 NC_002945.3 Mycobrowser_v2 CDS 1097959 1099473 . + 0 Mb1008 mprB two component sensor kinase mprb Mb1008, mprB, len: 504 aa. Equivalent to Rv0982,len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 504 aa overlap). Probable mprB, two component sensor kinase, transmembrane protein (EC 2.7.3.-) (see citation below), equivalent to AL035500|MLCL373_16|NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa), FASTA score: (81.0% identity in 521 aa overlap). Also highly similar to others (especially in C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221 sensor kinase from Corynebacterium glutamicum (455 aa); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (481 aa); X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa),FASTA scores: opt: 451, E(): 4.2e-21, (36.0% identity in 303 aa overlap); P30847|BAES_ECOLI SENSOR PROTEIN (EC 2.7.3.-) from Escherichia coli (467 aa), FASTA scores: opt: 412, E(): 1.3e-18, (30.4% identity in 336 aa overlap); etc. Also similar in C-terminal region to C-terminus of Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4 identity in 462 aa overlap). X2BGP2,Q7U0X3 No regulatory proteins Rv0982 NC_002945.3 Mycobrowser_v2 CDS 1099517 1100911 . + 0 Mb1009 pepd probable serine protease pepd (serine proteinase) (mtb32b) Mb1009, -, len: 464 aa. Equivalent to Rv0983, len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 464 aa overlap). Probable secreted or membrane serine protease (EC 3.4.21.-), equivalent (but longer 18 aa in N-terminus) to AL035500|MLCL373_17|T45448 probable serine proteinase (EC 3.4.21.-) from Mycobacterium leprae (452 aa), FASTA score: (74.2% identity in 466 aa overlap); and highly similar to others from Mycobacterium leprae. Also highly similar (except in N-terminus) to other proteases e.g. CAC01350.1|AL390975 putative protease from Streptomyces coelicolor (542 aa); NP_440705.1|NC_000911|HtrA serine protease from Synechocystis sp. (452 aa); NP_346646.1|NC_003028 serine protease from Streptococcus pneumoniae (393 aa); etc. Also similar in part to members of the htrA-antigen family e.g. U87242|MTU87242_3|HtrA serine protease from M. tuberculosis (542 aa), FASTA scores: opt: 846, E(): 2e-28,(40.6% identity in 392 aa overlap); and similar to other hypothetical serine proteases e.g. Rv0983, Rv0125, etc. Q7U0X2 No intermediary metabolism and respiration Rv0983 NC_002945.3 Mycobrowser_v2 CDS 1100911 1101456 . + 0 Mb1010 moaB2 POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB2 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD) Mb1010, moaB2, len: 181 aa. Equivalent to Rv0984,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 181 aa overlap). Possible moaB2,pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),highly similar to NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa), FASTA score: (92.3% identity in 181 aa overlap). Also similar to others e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); Q56208|MOCB_SYNP7 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN CB from Synechococcus sp. (319 aa), FASTA score: (37.3% identity in 142 aa overlap); C-terminus of NP_197599.1|NC_003076 MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN from Arabidopsis thaliana (670 aa); etc. Also similar to Rv0865|MOG from Mycobacterium tuberculosis (160 aa); and other mog proteins e.g. CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa). COULD BELONG TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Alternative start codon has been suggested in position 1100508. Q7TTP6 No NC_002945.3 Mycobrowser_v2 CDS 1101476 1101931 . - 0 Mb1011c mscL POSSIBLE LARGE-CONDUCTANCE ION MECHANOSENSITIVE CHANNEL MSCL Mb1011c, mscL, len: 151 aa. Equivalent to Rv0985c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 151 aa overlap). Possible mscL, large conductance mechanosensitive ion channel (integral membrane protein), equivalent to AL035500|MLCL373_19|NP_301254.1|NC_002677 putative mechanosensitive channel protein from Mycobacterium leprae (154 aa), FASTA score: (71.0% identity in 155 aa overlap). Also highly similar to others e.g. NP_268999.1|NC_002737 putative large conductance mechanosensitive channel from Streptococcus pyogenes (120 aa); CAB90974.1|AL355832 putative mechanosensitive channel from Streptomyces coelicolor (156 aa); Q9X722|MSCL_CLOHI LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL from Clostridium histolyticum (133 aa); Z83337|BSZ83337_6 large conductance mechanosensitive channel from Bacillus subtilis (130 aa),FASTA scores: opt: 248, E(): 8.4e-10, (39.0% identity in 136 aa overlap); U08371|ECU08371_1 large conductance mechanosensitive channel from Escherichia coli strain K-12 (136 aa), FASTA score: (36.6% identity in 134 aa overlap); etc. BELONGS TO THE MSCL FAMILY. X2BGR4,P0A5K9 No NC_002945.3 Mycobrowser_v2 CDS 2063545 2064288 . + 0 Mb1859 conserved protein Mb1859, -, len: 247 aa. Equivalent to Rv1828, len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Conserved hypothetical protein, equivalent to O32918|MLCB1788.35c|AL008609 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1397,E(): 0, (87.6% identity in 251 aa overlap). X2BJ64,P67670 No conserved hypotheticals Rv1828 NC_002945.3 Mycobrowser_v2 CDS 1112063 1112674 . + 0 Mb1022 rimJ ribosomal-protein-alanine acetyltransferase rimj (acetylating enzyme for n-terminal of ribosomal protein s5) Mb1022, rimJ, len: 203 aa. Equivalent to Rv0995,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 203 aa overlap). Possible rimJ,ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), equivalent to AL035500|MLCL373_24 probable acyltransferase from Mycobacterium leprae (218 aa), FASTA scores: (86.0% identity in 200 aa overlap). Also similar to others and many acyltransferases e.g. BAB69252.1|AB070946 possible acyltransferase from Streptomyces avermitilis (156 aa); NP_385025.1|NC_003047 PROBABLE RIBOSOMAL-PROTEIN-ALANINE ACETYLTRANSFERASE from Sinorhizobium meliloti (203 aa); P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444 ribosomal-protein-alanine acetyltransferase from Escherichia coli strains K12 and O157:H7 (194 aa), FASTA scores: opt: 247, E(): 1.5e-10, (26.9% identity in 186 aa overlap). SEEMS TO BELONG TO THE ACETYLTRANSFERASE FAMILY,RIMJ SUBFAMILY. Q7U0W1 No information pathways Rv0995 NC_002945.3 Mycobrowser_v2 CDS 1109029 1109622 . - 0 Mb1019c CONSERVED HYPOTHETICAL PROTEIN Mb1019c, -, len: 197 aa. Equivalent to Rv0992c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Conserved hypothetical protein, equivalent to NP_301256.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (197 aa). Also similar, except in N-terminus, to other hypothetical proteins and ligases e.g. SCE87.34|CAB59679.1|AL132674 hypothetical protein from Streptomyces coelicolor (204 aa); NP_461977.1|NC_003197 putative ligase from Salmonella typhimurium (182 aa); P09160|YGFA_ECOLI HYPOTHETICAL 21.1 kDa PROTEIN from Escherichia coli (182 aa), FASTA scores: opt: 191, E(): 1.1e-09, (29.5% identity in 146 aa overlap); etc. Q7U0W4 No conserved hypotheticals Rv0992c NC_002945.3 Mycobrowser_v2 CDS 1102254 1103000 . + 0 Mb1012 PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER Mb1012, -, len: 248 aa. Equivalent to Rv0986, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 248 aa overlap). Probable ATP-binding protein ABC transporter supposed involved in transport of adhesion component (see citation below), highly similar to many ATP-binding proteins e.g. AE0010|AE001033_8 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 669, E(): 0, (45.7% identity in 219 aa overlap); CAB81857.1|AL161691 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa); X84019|ZMDNAGRP_4 glutamate uptake regulatory protein (grp) from Z.mobilis (232 aa), FASTA score: (44.4% identity in 225 aa overlap); Z99111|BSUB0008_108 from Bacillus subtilis (230 aa), FASTA score: (38.7% identity in 222 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7U0X1 No cell wall and cell processes Rv0986 NC_002945.3 Mycobrowser_v2 CDS 1102993 1104264 . + 0 Mb1013 PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb1013, -, len: 423 aa. Equivalent to 5' end of Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 423 aa overlap). Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below),whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265,E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Q7U0X0 No NC_002945.3 Mycobrowser_v2 CDS 1121340 1122599 . - 0 Mb1031c PROBABLE MEMBRANE PROTEIN Mb1031c, -, len: 419 aa. Equivalent to Rv1004c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 419 aa overlap). Probable membrane protein. Contains repetitive sequences, which have similarities with elastin, and possible N-terminal signal sequence. Q7U0V4 No cell wall and cell processes Rv1004c NC_002945.3 Mycobrowser_v2 CDS 1104265 1105560 . + 0 Mb1014 PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb1014, -, len: 431 aa. Equivalent to 3' end of Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 431 aa overlap). Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below),whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265,E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 into two parts, Mb1013 and Mb1014. Q7U0W9 No NC_002945.3 Mycobrowser_v2 CDS 1124165 1125868 . + 0 Mb1033 unknown protein Mb1033, -, len: 567 aa. Equivalent to Rv1006, len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 567 aa overlap). Hypothetical unknown protein. Q7U0V3 No conserved hypotheticals Rv1006 NC_002945.3 Mycobrowser_v2 CDS 1105567 1106727 . + 0 Mb1015 POSSIBLE CONSERVED EXPORTED PROTEIN Mb1015, -, len: 386 aa. Equivalent to Rv0988, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 386 aa overlap). Possible conserved exported protein, with potential N-terminal signal sequence, similar (except in N-terminus) to O32737|L63540 ATTH PROTEIN from Agrobacterium tumefaciens (355 aa),FASTA scores: opt: 651, E(): 5.7e-33, (33.4% identity in 344 aa overlap); and NP_231265.1|NC_002505 conserved hypothetical protein from Vibrio cholerae (372 aa). Q7U0W8 No cell wall and cell processes Rv0988 NC_002945.3 Mycobrowser_v2 CDS 1106856 1107833 . - 0 Mb1016c grcC2 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) Mb1016c, grcC2, len: 325 aa. Equivalent to Rv0989c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). Probable grcC2,polyprenyl diphosphate synthetase (EC 2.5.1.-), highly similar to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to heptaprenyl diphosphate synthase component II (menaquinone biosynthesis) from Listeria innocua (321 aa); NP_371994.1|NC_002758 heptaprenyl diphosphate syntase component II from Staphylococcus aureus subsp. aureus Mu50 (319 aa); P55785|HEP2_BACST heptaprenyl diphosphate synthase component from Bacillus subtilis (323 aa), FASTA scores: opt: 496, E(): 1.4e-24, (31.4% identity in 306 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins e.g. Rv0562|grcC1|NP_215076.1|MTCY25D10.41 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (335 aa); Rv3383, Rv3398c,Rv2173, etc. SEEMS TO BELONG TO THE FPP/GGPP SYNTHETASES FAMILY. Q7U0W7 No NC_002945.3 Mycobrowser_v2 CDS 1109723 1110643 . + 0 Mb1020 galU utp--glucose-1-phosphate uridylyltransferase galu (udp-glucose pyrophosphorylase) (udpgp) (alpha-d-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase) Mb1020, galU, len: 306 aa. Equivalent to Rv0993,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 306 aa overlap). Probable galU,UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9),equivalent to AL035500|MLCL373_22 putative UTP-glucose-1-phosphate uridylyltransferase from Mycobacterium leprae (306 aa), FASTA score: (89.7% identity in 302 aa overlap). Also highly similar to others e.g. AB59678.1|AL132674 UTP-glucose-1-phosphate uridylyltransferase from Streptomyces coelicolor (303 aa); NP_244519.1|NC_002570 UTP-glucose-1-phosphate uridylyltransferase from Bacillus halodurans (297 aa); P25520|GALU_ECOLI|B1236|Z2012|ECS17 UTP--glucose-1-phosphate uridylyltransferase from Escherichia coli strains K12 and O157:H7 (301 aa), FASTA scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa overlap); etc. BELONGS TO THE PROKARYOTIC UDPGP FAMILY. Q7U0W3 No intermediary metabolism and respiration Rv0993 NC_002945.3 Mycobrowser_v2 CDS 1110720 1112000 . + 0 Mb1021 moeA1 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA1 Mb1021, moeA1, len: 426 aa. Equivalent to Rv0994,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 426 aa overlap). Probable moeA1,molybdenum cofactor biosynthesis protein, equivalent to AL035500|MLCL373_23 putative molybdopterin biosynthesis protein from Mycobacterium leprae (424 aa), FASTA score: (88.3% identity in 426 aa overlap). Also highly similar to many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis protein from Streptomyces coelicolor (424 aa); NP_385769.1|NC_003047 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Sinorhizobium meliloti (406 aa); P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein from Escherichia coli (411 aa), FASTA scores: opt: 519,E(): 1.3e-24, (32.3% identity in 402 aa overlap); etc. Also similar to MOEA2|Rv0438c|MTV037.02c PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (405 aa). Note that previously known as moeA. Q7U0W2 No NC_002945.3 Mycobrowser_v2 CDS 1165539 1165946 . - 0 Mb1071c probable is like-2 transposase Mb1071c, -, len: 135 aa. Equivalent to Rv1042c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 135 aa overlap). Probable IS like-2 transposase, similar to Q50761 TRANSPOSASE from Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1149. Q7U0T3 No insertion seqs and phages Rv1042c NC_002945.3 Mycobrowser_v2 CDS 1147466 1148425 . + 0 Mb1054 conserved protein Mb1054, -, len: 319 aa. Equivalent to Rv1026, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 319 aa overlap). Conserved hypothetical protein. Equivalent to AL023514|MLCB4.02 hypothetical protein from Mycobacterium leprae (317 aa) (77.9% identity in 321 aa overlap). Similar to GPPA_ECOLI|P25552 guanosine-5'-triphosphate, 3'-diphosphate pyrophoshatase from Escherichia coli (494 aa), FASTA scores: opt: 281,E(): 3.2e-11, (30.6% identity in 291 aa overlap). Q7U0U3 No virulence, detoxification, adaptation Rv1026 NC_002945.3 Mycobrowser_v2 CDS 1115199 1116200 . + 0 Mb1025 CONSERVED HYPOTHETICAL PROTEIN Mb1025, -, len: 333 aa. Equivalent to Rv0998, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 333 aa overlap). Conserved hypothetical protein, possibly cyclic nucleotide-dependent protein kinase (EC 2.7.-.-), highly similar to NP_301261.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (353 aa); and AL035500|MLCL373.38|T45457 hypothetical protein from Mycobacterium leprae (143 aa), FASTA score: (61.5% identity in 143 aa overlap). Also similar to many hypothetical proteins and cyclic-NMP-dependent protein kinases (generally at C-terminus) e.g. N-terminus of SC9B10.09|T35878 hypothetical protein from Streptomyces coelicolor (1039 aa); P05987|KAPR_DICDI CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN (EC 2.7.1.37) from Dictyostelium discoideum (327 aa), FASTA scores: opt: 177,E(): 0.00036, (32.0% identity in 122 aa overlap); NP_104403.1|NC_002678 hypothetical protein (contains similarity to cAMP-dependent protein kinase regulatory subunit) from Mesorhizobium loti (151 aa); etc. Contains PS00889 Cyclic nucleotide-binding domain signature 2. Q7U0V8 No conserved hypotheticals Rv0998 NC_002945.3 Mycobrowser_v2 CDS 1116218 1116976 . + 0 Mb1026 unknown protein Mb1026, -, len: 252 aa. Equivalent to Rv0999, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 252 aa overlap). Hypothetical unknown protein. Q7U0V7 No conserved hypotheticals Rv0999 NC_002945.3 Mycobrowser_v2 CDS 1279265 1279672 . + 0 Mb1180 POSSIBLE TRANSPOSASE Mb1180, -, len: 135 aa. Equivalent to Rv1149, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 135 aa overlap). Possible transposase. Identical to 117 aa N-terminal region of S21394|X65618 transposase of Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1042c|MTCY10G2.07. TBparse score is 0.926. Q7U0J2 No insertion seqs and phages Rv1149 NC_002945.3 Mycobrowser_v2 CDS 1116982 1117599 . - 0 Mb1027c CONSERVED HYPOTHETICAL PROTEIN Mb1027c, -, len: 205 aa. Equivalent to Rv1000c,len: 205 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 205 aa overlap). Conserved hypothetical protein, equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from Streptomyces coelicolor (210 aa), FASTA scores: E(): 2.1e-45, (56.8% identity); 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein described as DNA repair system specific for alkylated DNA from Xylella fastidiosa (200 aa), FASTA scores: E(): 3.4e-14, (38.55% identity); and similar in C-terminus to other hypothetical proteins. Note that replaces original Rv1000 predicted on other strand. Q7U0V6 No conserved hypotheticals Rv1000c NC_002945.3 Mycobrowser_v2 CDS 1117636 1118844 . + 0 Mb1028 arcA PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD) (ARGININE DIHYDROLASE) Mb1028, arcA, len: 402 aa. Equivalent to Rv1001,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 402 aa overlap). Probable arcA, arginine deiminase (EC 3.5.3.6), similar to e.g. ARCA_PSEAE|P13981 arginine deiminase (417 aa), fasta scores: opt: 581, E(): 1.4e-31, (39.4% identity in 411 aa overlap); also similar to SAGP_STRPY|P16962 streptococcal acid glycoprotein (410 aa), FASTA scores, opt: 823, E():0, (38.3% identity in 402 aa overlap). BELONGS TO THE ARGININE DEIMINASE FAMILY. X2BGU7,P63552 No intermediary metabolism and respiration Rv1001 NC_002945.3 Mycobrowser_v2 CDS 1168121 1169002 . + 0 Mb1074 HYPOTHETICAL PROTEIN Mb1074, -, len: 293 aa. Equivalent to Rv1045, len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 293 aa overlap). Hypothetical unknown protein. Q7U0T0 No conserved hypotheticals Rv1045 NC_002945.3 Mycobrowser_v2 CDS 1118879 1120390 . - 0 Mb1029c CONSERVED MEMBRANE PROTEIN Mb1029c, -, len: 503 aa. Equivalent to Rv1002c,len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 503 aa overlap). Conserved membrane protein. Similar to AL132674|SCE87.05 hypothetical protein from Streptomyces coelicolor (591 aa), FASTA scores: opt: 666, E(): 0, (39.0% identity in 546 aa overlap); weakly similar to TSCC_PSEAM|P55019 thiazide-sensitive sodium-chloride cotransporter from Pseudopleuronectes americanus (1023 aa), FASTA scores: opt: 44, E(): 4.2e-06,(22.4% identity in 326 aa overlap). Q7U0V5 No cell wall and cell processes Rv1002c NC_002945.3 Mycobrowser_v2 CDS 1120473 1121330 . + 0 Mb1030 conserved protein Mb1030, -, len: 285 aa. Equivalent to Rv1003, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 285 aa overlap). Conserved hypothetical protein, similar to others e.g. AL132674|SCE87.04 Streptomyces coelicolor (286 aa), FASTA scores: opt: 877,E(): 0, (53.2% identity in 280 aa overlap); and YRAL_ECOLI|P45528 hypothetical 31.3 kd protein (286 aa),FASTA scores: opt: 561, E(): 4.4e-27, (36.9% identity in 279 aa overlap). X2BGS7,P0A641 No conserved hypotheticals Rv1003 NC_002945.3 Mycobrowser_v2 CDS 1122673 1124109 . - 0 Mb1032c pabB Probable para-aminobenzoate synthase component I PABD Mb1032c, pabB, len: 478 aa. Similar to Rv1005c,len: 458 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 457 aa overlap). Probable PabD,para-aminobenzoate synthase component I (EC 4.1.3.-). Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase component I from Escherichia coli (453 aa), FASTA scores: opt: 589, E(): 1.8e-27, (40.7% identity in 268 aa overlap). Similar to Mycobacterium tuberculosis Rv1609,Rv3215, Rv2386c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (g-a) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (478 aa versus 458 aa). Q7VF03 No NC_002945.3 Mycobrowser_v2 CDS 1169084 1169677 . - 0 Mb1075c HYPOTHETICAL PROTEIN Mb1075c, -, len: 197 aa. Equivalent to Rv1046c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 174 aa overlap). Hypothetical unknown protein. Start changed since first submission (-65 aa). Q7U0S9 No unknown Rv1046c NC_002945.3 Mycobrowser_v2 CDS 1125895 1127454 . - 0 Mb1034c metS methionyl-trna synthetase mets (metrs) (methionine--trna ligase) Mb1034c, metS, len: 519 aa. Equivalent to Rv1007c,len: 519 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 519 aa overlap). Probable metS (MetG),methionyl-tRNA synthetase (EC 6.1.1.10), similar to many e.g. SYM_BACSU|P37465 methionyl-tRNA synthetase from Bacillus subtilus (664 aa), FASTA scores: opt: 1506, E(): 0, (44.9% identity in 492 aa overlap); similar to other M. tuberculosis tRNA synthases e.g. Rv2448c, Rv1536, Rv0041. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. STRONG, TO CYSTEINYL-TRNA SYNTHETASE. X2BGZ0,P59952 No NC_002945.3 Mycobrowser_v2 CDS 1127540 1128334 . + 0 Mb1035 tatD Probable deoxyribonuclease TatD (YjjV protein) Mb1035, tatD, len: 264 aa. Equivalent to Rv1008,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable tatD (alternate gene name: yjjV), deoxyribonuclease (EC 3.1.21.-), component of twin arginine translocation protein export system (see citation below for more information). Similar to many members of the YBL055C/YJJV family e.g. YCFH_ECOLI|P37346 Putative deoxyribonuclease ycfH (EC 3.1.21.-) (265 aa), fasta scores: opt: 487, E(): 1.4e-24, (36.7% identity in 270 aa overlap). Also similar to P37545|YABD_BACSU Putative deoxyribonuclease yabD (255 aa), FASTA scores: opt: 599, E(): 7.7e-33, (40.1% identity in 262 aa overlap). Contains PS01137 Hypothetical YBL055c/yjjV family signature 1, and PS01091 Hypothetical YBL055c/yjjV family signature 3. Q7VF02 No cell wall and cell processes Rv1008 NC_002945.3 Mycobrowser_v2 CDS 1128542 1129630 . + 0 Mb1036 rpfB Probable resuscitation-promoting factor rpfB Mb1036, rpfB, len: 362 aa. Equivalent to Rv1009,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 362 aa overlap). Probable rpfB,resuscitation-promoting factor (see citation below),similar to others from Mycobacterium tuberculosis: Rv2450c|MTV008.06c|RPFE PROBABLE RESUSCITATION-PROMOTING FACTOR (172 aa), FASTA scores: E(): 1.9e-19, (42.9% identity in 147 aa overlap); Rv0867c|RPFA, Rv1884c|RPFC,and Rv2389c|RPFD. Possible lipoprotein; contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7VF01 No cell wall and cell processes Rv1009 NC_002945.3 Mycobrowser_v2 CDS 1133785 1134360 . - 0 Mb1042c pth PROBABLE PEPTIDYL-TRNA HYDROLASE PTH Mb1042c, pth, len: 191 aa. Equivalent to Rv1014c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 191 aa overlap). Probable pth,peptidyl-tRNA hydrolase (EC 3.1.1.29), similar to PTH_ECOLI|P23932 peptidy l-trna hydrolase from Escherichia coli (194 aa), FASTA scores: opt: 472, E(): 2.3e-25,(39.6% identity in 187 aa overlap). BELONGS TO THE PTH FAMILY. X2BGI9,P65866 No NC_002945.3 Mycobrowser_v2 CDS 1129603 1130556 . + 0 Mb1037 ksgA PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase) Mb1037, ksgA, len: 317 aa. Equivalent to Rv1010,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 317 aa overlap). Probable ksgA,dimethyladenosine transferase (EC 2.1.1.-), similar to many e.g. KSGA_BACSU|P37468 dimethyladenosine transferase from Bacillus subtilus (292 aa), FASTA scores: opt: 524,E(): 1.5e-28, (37.2% identity in 274 aa overlap); similar to Mycobacterium tuberculosis hypothetical protein Rv1988. Contains PS01131 Ribosomal RNA adenine dimethylases signature. X2BGQ3,P66661 No information pathways Rv1010 NC_002945.3 Mycobrowser_v2 CDS 1576898 1577380 . + 0 Mb1439 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1439, -, len: 160 aa. Equivalent to Rv1404, len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 160 aa overlap). Probable transcriptional regulatory protein, some similarity to MARR_ECOLI|P27245 multiple antibiotic resistance protein from Escherichia coli (125 aa), FASTA scores: opt: 136,E(): 0.004, (35.1% identity in 74 aa overlap). Q7U045 No regulatory proteins Rv1404 NC_002945.3 Mycobrowser_v2 CDS 1130642 1131562 . + 0 Mb1038 ispE Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ISPE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) Mb1038, ispE, len: 306 aa. Equivalent to Rv1011,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 306 aa overlap). Probable ispE,4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.-), similar to others e.g. Q9K3R6|ISPE_STRCO Streptomyces coelicolor (299 aa), FASTA scores: opt: 925,E(): 2.7e-49, (54.5% identity in 297 overlap); etc. BELONGS TO THE ISPE FAMILY. X2BGV6,P65179 No intermediary metabolism and respiration Rv1011 NC_002945.3 Mycobrowser_v2 CDS 1131559 1131873 . + 0 Mb1040 HYPOTHETICAL PROTEIN Mb1040, -, len: 104 aa. Equivalent to the 3' end of Rv1012, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv, (98.4% identity in 63 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a different NH2 terminus. Q7U0V2 No NC_002945.3 Mycobrowser_v2 CDS 1132077 1133711 . + 0 Mb1041 pks16 PUTATIVE POLYKETIDE SYNTHASE PKS16 Mb1041, pks16, len: 544 aa. Equivalent to Rv1013,len: 544 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 544 aa overlap). Putative pks16,polyketide synthase, similar to many e.g. N-terminus of Q50857|U24657 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa), FASTA scores: opt: 526, E(): 1.4e-25, (29.3% identity in 542 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U0V1 No NC_002945.3 Mycobrowser_v2 CDS 1134373 1135020 . - 0 Mb1043c rplY 50s ribosomal protein l25 rply Mb1043c, rplY, len: 215 aa. Equivalent to Rv1015c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Probable rplY, 50s ribosomal protein L25, similar to RL25_ECOLI|P02426 50s ribosomal protein L25 from Escherichia coli (94 aa), FASTA scores: opt: 182, E(): 2.5e-05, (38.4% identity in 86 aa overlap) and to CTC_BACSU|P14194 general stress protein from Bacillus subtilis (203 aa), FASTA scores: opt: 260,E(): 1.4e-09, (28.4% identity in 201 aa overlap). BELONGS TO THE L25P FAMILY OF RIBOSOMAL PROTEINS. X2BGQ7,P66122 No NC_002945.3 Mycobrowser_v2 CDS 1169872 1171119 . + 0 Mb1076 probable transposase Mb1076, -, len: 415 aa. Equivalent to Rv1047, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). IS1081 transposase,most similar to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa), FASTA scores: opt: 2675, E(): 0, (99.8% identity in 415 aa overlap). Contains PS01007 Transposases, Mutator family, signature X2BGW7,P60231 No insertion seqs and phages Rv1047 NC_002945.3 Mycobrowser_v2 CDS 1135154 1135912 . - 0 Mb1044c lpqT probable conserved lipoprotein lpqt Mb1044c, lpqT, len: 252 aa. Equivalent to 5' end of Rv1016c, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv, (98.9% identity in 190 aa overlap). Probable lpqT, conserved lipoprotein. Similar to several M. tuberculosis hypothetical proteins e.g. Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310 aa), FASTA scores: opt: 329, E(): 2e-17, (32.3% identity in 229 aa overlap); Rv0583c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cacgc-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. X2BGW0,Q7U0V0 No NC_002945.3 Mycobrowser_v2 CDS 1135948 1136928 . - 0 Mb1045c prsA PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE PRSA (Phosphoribosyl pyrophosphate synthetase) (PRPP synthetase) Mb1045c, prsA, len: 326 aa. Equivalent to Rv1017c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable prsA,ribose-phosphate pyrophosphokinase (EC 2.7.6.1), highly similar to others e.g. KPRS_ECOLI|P08330 ribose-phosphate pyrophosphokinase from Escherichia coli (314 aa), FASTA scores: opt: 826, E(): 0, (43.8% identity in 317 aa overlap). Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature; contains PS00144 Asparaginase / glutaminase active site signature 1. BELONGS TO THE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE FAMILY. COFACTOR: BOTH INORGANIC PHOSPHATE AND MAGNESIUM ION ARE REQUIRED FOR ENZYME STABILITY AND ACTIVITY (by similarity). X2BH02,P65233 No NC_002945.3 Mycobrowser_v2 CDS 1165019 1165570 . - 0 Mb1070c probable is like-2 transposase Mb1070c, -, len: 183 aa. Equivalent to Rv1041c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 183 aa overlap). Probable IS like-2 transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (186 aa), FASTA scores: opt: 173, E(): 0.00016, (40.9% identity in 176 aa overlap). Similar to Rv1150, C-terminal part of transposase of putative Mycobacterium tuberculosis IS like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with respect to Mycobacterium tuberculosis Q50761 transposase,the 10G2 cosmid sequence appears to be correct. No insertion seqs and phages Rv1041c NC_002945.3 Mycobrowser_v2 CDS 1137020 1138507 . - 0 Mb1046c glmU Probable UDP-N-acetylglucosamine pyrophosphorylase glmU Mb1046c, glmU, len: 495 aa. Equivalent to Rv1018c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 495 aa overlap). Probable glmU,UDP-n-acetylglucosamine pyrophosphorylase (EC 2.7.7.23),similar to GCAD_BACSU|P14192 UDP-n-acetylglucosamine pyrophosphorylase (456 aa), FASTA scores: opt: 1150, E(): 0, (40.0% identity in 453 aa overlap). Similar to various Mycobacterium tuberculosis sugar-phosphate transferases e.g. Rv0334, Rv1213, Rv3264c, etc. X2BGT8,Q7VF00 No NC_002945.3 Mycobrowser_v2 tRNA 1138523 1138594 . - 0 glnT glnT tRNA-Gln glnT, len: 72 nt. Equivalent to glnT, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Gln, anticodon ttg. No NC_002945.3 Mycobrowser_v2 CDS 1138762 1139355 . + 0 Mb1047 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb1047, -, len: 197 aa. Equivalent to Rv1019, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 197 aa overlap). Probable transcriptional regulator, similar to many memebers of the tetR family e.g. MTCY7D11.18c (34.4% identity in 189 aa overlap). Helix turn helix motif from aa 27-48 (+5.42 SD). Q7U0U9 No regulatory proteins Rv1019 NC_002945.3 Mycobrowser_v2 CDS 1139414 1143118 . + 0 Mb1048 mfd PROBABLE TRANSCRIPTION-REPAIR COUPLING FACTOR MFD (TRCF) Mb1048, mfd, len: 1234 aa. Equivalent to Rv1020,len: 1234 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1234 aa overlap). Probable mfd,transcription-repair coupling factor, similar to many e.g. MFD_ECOLI|P30958 transcription-repair coupling factor from Escherichia coli (1148 aa), FASTA scores: opt: 1900, E(): 0, (37.9% identity in 1107 aa overlap). Also similar to M. tuberculosis Rv2973c and Rv1633. Contains PS00017 ATP/GTP-binding site motif A (P-loop). IN THE N-TERMINAL SECTION; BELONGS TO THE UVRB FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HELICASE FAMILY. RECG SUBFAMILY. X2BGR0,P64327 No information pathways Rv1020 NC_002945.3 Mycobrowser_v2 CDS 1143118 1144095 . + 0 Mb1049 conserved protein Mb1049, -, len: 325 aa. Equivalent to Rv1021, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 325 aa overlap). Conserved hypothetical protein, similar to YBL1_STRCI|P33653 hypothetical 26.1 kd protein from Streptomyces cacaoi (242 aa), FASTA scores: opt: 493, E(): 1.1e-23, (42.9% identity in 238 aa overlap). Q7U0U8 No conserved hypotheticals Rv1021 NC_002945.3 Mycobrowser_v2 CDS 1144183 1144914 . + 0 Mb1050 lpqU probable conserved lipoprotein lpqu Mb1050, lpqU, len: 243 aa. Equivalent to Rv1022,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 243 aa overlap). Probable lpqU conserved lipoprotein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1230c|MTV006.02C,FASTA scores: E(): 2.8e-18, (37.9% identity in 240 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa), FASTA scores: opt: 474, E(): 2.7e-21, (42.2% identity in 211 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U0U7 No cell wall and cell processes Rv1022 NC_002945.3 Mycobrowser_v2 CDS 1145011 1146300 . + 0 Mb1051 eno PROBABLE ENOLASE ENO Mb1051, eno, len: 429 aa. Equivalent to Rv1023,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 429 aa overlap). Probable eno, enolase (EC 4.2.1.11), highly similar to others e.g. ENO_ECOLI|P08324 enolase from Escherichia coli (431 aa),FASTA scores: opt: 1487, E(): 0, (55.5% identity in 422 aa overlap); etc. MAGNESIUM IS REQUIRED FOR CATALYSIS AND FOR STABILIZING THE DIMER. BELONGS TO THE ENOLASE FAMILY. X2BGU2,Q7U0U6 No intermediary metabolism and respiration Rv1023 NC_002945.3 Mycobrowser_v2 CDS 1146305 1146991 . + 0 Mb1052 possible conserved membrane protein Mb1052, -, len: 228 aa. Equivalent to Rv1024, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Hypothetical unknown protein, hydrophobic region from aa 83-101. Q7U0U5 No cell wall and cell processes Rv1024 NC_002945.3 Mycobrowser_v2 CDS 1147008 1147475 . + 0 Mb1053 conserved protein Mb1053, -, len: 155 aa. Equivalent to Rv1025, len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 155 aa overlap). Conserved hypothetical protein, similar to AE001768|AE001768_4 hypothetical protein from Thermotoga maritima (170 aa), FASTA scores: opt: 254, E(): 9.5e-10, (35.7% identity in 143 aa overlap). Q7U0U4 No conserved hypotheticals Rv1025 NC_002945.3 Mycobrowser_v2 CDS 1148874 1149554 . - 0 Mb1055c kdpE PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN KDPE Mb1055c, kdpE, len: 226 aa. Equivalent to Rv1027c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 226 aa overlap). Probable KdpE,transcriptional regulatory protein, similar to others e.g. KDPE_ECOLI|P21866 kdp operon transcriptional regulatory protein from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 691, E(): 0, (47.8% identity in 224 aa overlap); AL021530|SC2E9.13 from Streptomyces coelicolor (227 aa), FASTA scores: opt: 981, E(): 0, (66.4% identity in 226 aa overlap); etc. Q7U0U2 No NC_002945.3 Mycobrowser_v2 CDS 1149551 1152133 . - 0 Mb1056c kdpD PROBABLE SENSOR PROTEIN KDPD Mb1056c, kdpD, len: 860 aa. Equivalent to Rv1028c,len: 860 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 860 aa overlap). Probable kdpD, sensor protein (EC 2.7.3.-), similar to others e.g. KDPD_ECOLI|P21865 sensor protein from Escherichia coli strain K12 (894 aa), FASTA scores: opt: 1041, E(): 0,(32.3% identity in 888 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U0U1 No NC_002945.3 Mycobrowser_v2 CDS 1152367 1152459 . + 0 Mb1057 kdpF Probable membrane protein kdpF Mb1057, kdpF, len: 30 aa. Equivalent to Rv1028A,len: 30 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 30 aa overlap). Probable kdpF, membrane protein, showing similarity with P36937|KDPF_ECOLI|B0698.1 PROTEIN KDPF from Escherichia coli strain K12 (see citation below) (27% identity); and KdpF protein from Streptomyces coelicolor (51% identity). Q7VEZ9 No cell wall and cell processes Rv1028A NC_002945.3 Mycobrowser_v2 CDS 1152459 1154174 . + 0 Mb1058 kdpA Probable Potassium-transporting ATPase A chain KDPA (Potassium-translocating ATPase A chain) (ATP phosphohydrolase [potassium-transporting] A chain) (Potassium binding and translocating subunit A) Mb1058, kdpA, len: 571 aa. Equivalent to Rv1029,len: 571 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 571 aa overlap). Probable kdpA,potassium-transporting ATPase A chain (transmembrane protein) (EC 3.6.3.12), similar to others e.g. ATKA_ECOLI|P03959|KDPA|B0698 potassium-transporting ATPase A chain from Escherichia coli strain K12 (557 aa), FASTA scores: opt: 1763, E(): 0, (50.4% identity in 569 aa overlap); etc. BELONGS TO THE KDPA FAMILY. X2BGR6,P65210 No cell wall and cell processes Rv1029 NC_002945.3 Mycobrowser_v2 CDS 1154171 1156300 . + 0 Mb1059 kdpB Probable Potassium-transporting P-type ATPase B chain KDPB (Potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium binding and translocating subunit B) Mb1059, kdpB, len: 709 aa. Equivalent to Rv1030,len: 709 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 709 aa overlap). Probable kdpB,potassium-transporting P-type ATPase B chain (transmembrane protein) (EC 3.6.3.12), similar to others e.g. ATKB_ECOLI|P03960 potassium-transporting ATPase B chain from Escherichia coli strain K12 (682 aa), FASTA scores: opt: 1481, E(): 0, (63.4% identity in 686 aa overlap); etc. Very similar to AL078610|SCH35.47 H+/K+-exchanging ATPase (EC 3.6.1.36) chain B from Streptomyces coelicolor (707 aa), FASTA scores: opt: 2731,E(): 0, (71.6% identity in 676 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site. X2BGX3,P63682 No cell wall and cell processes Rv1030 NC_002945.3 Mycobrowser_v2 CDS 1156300 1156869 . + 0 Mb1060 kdpC Probable Potassium-transporting ATPase C chain KDPC (Potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (Potassium binding and translocating subunit C) Mb1060, kdpC, len: 189 aa. Equivalent to Rv1031,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 189 aa overlap). Probable kdpC,potassium-transporting ATPase C chain (membrane protein) (EC 3.6.3.12), similar to others e.g. ATKC_ECOLI|P03961 potassium-transporting ATPase C chain from Escherichia coli strain K12 (190 aa), FASTA scores: opt: 475, E(): 3.1e-24, (45.7% identity in 186 aa overlap); etc. BELONGS TO THE KDPC FAMILY. X2BH18,P65212 No cell wall and cell processes Rv1031 NC_002945.3 Mycobrowser_v2 CDS 1156873 1158402 . - 0 Mb1061c trcS TWO COMPONENT SENSOR HISTIDINE KINASE TRCS Mb1061c, trcS, len: 509 aa. Equivalent to Rv1032c,len: 509 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 509 aa overlap). trcS, two component sensor histidine kinase protein (EC 2.7.3.-) (see citations below), similar to YV16_MYCLE|P54883 probable sensor-like histidine kinase from Mycobacterium leprae (443 aa), FASTA scores: opt: 392, E(): 3.8e-18, (31.7% identity in 334 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+. Q7U0U0 No NC_002945.3 Mycobrowser_v2 CDS 1158410 1159183 . - 0 Mb1062c trcR TWO COMPONENT TRANSCRIPTIONAL REGULATOR TRCR Mb1062c, trcR, len: 257 aa. Equivalent to Rv1033c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). trcR, two-component regulatory protein (see citations below), similar to Q50825 TWO COMPONENT RESPONSE REGULATOR from Mycobacterium tuberculosis (234 aa), FASTA scores: opt: 628, E(): 0,(46.0% identity in 226 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+. Q7U0T9 No NC_002945.3 Mycobrowser_v2 CDS 1159365 1159754 . - 0 Mb1063c PROBABLE TRANSPOSASE (FRAGMENT) Mb1063c, -, len: 129 aa. Equivalent to Rv1034c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Probable IS1560 transposase fragment, similar to part of Rv3387|E1202305|MTV004.45 (225 aa) (65.1% identity in 129 aa overlap). Q7U0T8 No insertion seqs and phages Rv1034c NC_002945.3 Mycobrowser_v2 CDS 1159822 1160508 . - 0 Mb1064c PROBABLE TRANSPOSASE (FRAGMENT) Mb1064c, -, len: 228 aa. Equivalent to Rv1035c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Probable IS1560 transposase fragment, similar to parts of Rv3387|E1202305|MTV004.45 (225 aa) (47.8% identity in 67 aa overlap) and Rv3386|E1202304|MTV004.44 (234 aa) (55.1% identity in 127 aa overlap). Q7U0T7 No insertion seqs and phages Rv1035c NC_002945.3 Mycobrowser_v2 CDS 1160542 1160880 . - 0 Mb1065c PROBABLE IS1560 TRANSPOSASE (FRAGMENT) Mb1065c, -, len: 112 aa. Equivalent to Rv1036c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 112 aa overlap). Probable IS1560 transposase fragment, similar to part of Rv3386|E1202304|MTV004.44 (234 aa) (82.8% identity in 87 aa overlap). Q7U0T6 No insertion seqs and phages Rv1036c NC_002945.3 Mycobrowser_v2 CDS 1160991 1161275 . - 0 Mb1066c esxI putative esat-6 like protein esxi (esat-6 like protein 1) Mb1066c, esxI, len: 94 aa. Equivalent to Rv1037c,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 94 aa overlap). esxI, conserved hypothetical protein, member of ESAT-6 family, highly similar to many Mycobacterial hypothetical proteins e.g. Q49946|ES6X_MYCLE|U1756D PUTATIVE ESAT-6 LIKE PROTEIN X from Mycobacterium leprae (95 aa), FASTA scores: opt: 409,E(): 6.3e-23, (64.15% identity in 92 aa overlap); Rv3619c,Rv1198, Rv2346c, etc from Mycobacterium tuberculosis. Strictly identical to P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT3721 PUTATIVE ESAT-6 LIKE PROTEIN 1 (94 aa). BELONGS TO THE ESAT6 FAMILY. X2BGV7 No NC_002945.3 Mycobrowser_v2 CDS 1161302 1161598 . - 0 Mb1067c esxJ esat-6 like protein esxj (esat-6 like protein 2) Mb1067c, esxJ, len: 98 aa. Equivalent to Rv1038c,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 98 aa overlap). esxJ, putative ESAT-6 like protein 2, similar to Q49945|U1756C, Mycobacterium leprae (100 aa), FASTA scores: opt: 375, E(): 7.7e-21,(58.3% identity in 96 aa overlap), almost identical to Rv1197, Rv1792, Rv2347c and Rv3620c. BELONGS TO THE ESAT6 FAMILY. X2BGJ8 No NC_002945.3 Mycobrowser_v2 CDS 1161744 1162919 . - 0 Mb1068c PPE15 ppe family protein ppe15 Mb1068c, PPE15, len: 391 aa. Equivalent to Rv1039c,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 391 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv2768c|AL008967|MTV002_33 Mycobacterium tuberculosis H37Rv (394 aa), FASTA scores: opt: 1721, E(): 0, (70.4% identity in 398 aa overlap). Q7U0T5 No NC_002945.3 Mycobrowser_v2 CDS 1162996 1163823 . - 0 Mb1069c PE8 pe family protein pe8 Mb1069c, PE8, len: 275 aa. Equivalent to Rv1040c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Member of the Mycobacterium tuberculosis PE family, most similar to AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 aa), FASTA scores: opt: 1111, E(): 0, (68.6% identity in 283 aa overlap). Q7U0T4 No NC_002945.3 Mycobrowser_v2 CDS 1166229 1167254 . - 0 Mb1072c CONSERVED HYPOTHETICAL PROTEIN Mb1072c, -, len: 341 aa. Equivalent to Rv1043c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 341 aa overlap). Conserved hypothetical protein similar to AL096872|SC5F7.08 PUTATIVE LIPOATE-PROTEIN LIGASE from Streptomyces coelicolor (362 aa), FASTA scores: opt: 206, E(): 1.4e-05, (30.3% identity in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU HYPOTHETICAL PROTEASE from Bacillus subtitis (400 aa),FASTA scores: opt: 159, E(): 0.013, (27.1% identity in 210 aa overlap). Q7U0T2 No conserved hypotheticals Rv1043c NC_002945.3 Mycobrowser_v2 CDS 1167501 1168124 . + 0 Mb1073 CONSERVED HYPOTHETICAL PROTEIN Mb1073, -, len: 207 aa. Equivalent to Rv1044, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 207 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap). Q7U0T1 No conserved hypotheticals Rv1044 NC_002945.3 Mycobrowser_v2 CDS 1174393 1175148 . - 0 Mb1080c CONSERVED HYPOTHETICAL PROTEIN Mb1080c, -, len: 251 aa. Equivalent to Rv1051c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 251 aa overlap). Conserved hypothetical protein, similar to LLU36837|U36837.1 protein encoded by Lactococcus lactis plasmid pNP40 (298 aa), FASTA scores: opt: 194, E(): 3.5e-06, (30.3% identity in 155 aa overlap). Contains possible helix-turn-helix motif at aa 197-218 (Score 1097, +2.92 SD). Q7U0S5 No conserved hypotheticals Rv1051c NC_002945.3 Mycobrowser_v2 CDS 1176171 1176560 . + 0 Mb1081 HYPOTHETICAL PROTEIN Mb1081, -, len: 129 aa. Equivalent to Rv1052, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Hypothetical unknown protein. Q7U0S4 No conserved hypotheticals Rv1052 NC_002945.3 Mycobrowser_v2 CDS 1176459 1176734 . - 0 Mb1082c HYPOTHETICAL PROTEIN Mb1082c, -, len: 91 aa. Equivalent to Rv1053c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 91 aa overlap). Hypothetical unknown protein. Q7U0S3 No conserved hypotheticals Rv1053c NC_002945.3 Mycobrowser_v2 CDS 1177376 1177690 . + 0 Mb1083 probable integrase (fragment) Mb1083, -, len: 104 aa. Equivalent to Rv1054, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable integrase (fragment), similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 273, E(): 8.8e-13, (64.7% identity in 68 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa), FASTA scores: opt: 105, E(): 0.9, (31.8% identity in 85 aaoverlap). This ORF continues in another frame as Rv1055|MTV017.08 but no error can be found to account for frameshift. Length extended since first submission (+36 aa). Q7U0S2 No insertion seqs and phages Rv1054 NC_002945.3 Mycobrowser_v2 CDS 1177687 1177821 . + 0 Mb1084 POSSIBLE INTEGRASE (FRAGMENT) Mb1084, -, len: 44 aa. Equivalent to Rv1055, len: 44 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 44 aa overlap). Possible integrase (fragment); first 49 aa similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 291, E(): 2.2e-16, (74.3% identity in 70 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa),FASTA scores: opt: 146, E(): 8.3e-05, (52.1% identity in 48 aa overlap); and to many other integrases or transposases. Shortened since first submission (-34 aa). Q7U0S1 No insertion seqs and phages Rv1055 NC_002945.3 Mycobrowser_v2 CDS 1178076 1178840 . + 0 Mb1085 conserved protein Mb1085, -, len: 254 aa. Equivalent to Rv1056, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 254 aa overlap). Conserved hypothetical protein, some similarity in C-terminal region of Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126 aa), FASTA scores: opt: 254, E(): 1.2e-10, (43.4% identity in 106 aa overlap); and to Rv1670. C-terminal region is similar to AL035569|SC8D9.02 hypothetical protein from Streptomyces coelicolor (113 aa), FASTA scores: opt: 282,E(): 4.5e-12, (48.0% identity in 100 aa overlap). Q7U0S0 No conserved hypotheticals Rv1056 NC_002945.3 Mycobrowser_v2 CDS 1188446 1188841 . + 0 Mb1095 CONSERVED HYPOTHETICAL PROTEIN Mb1095, -, len: 131 aa. Equivalent to Rv1066, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 131 aa overlap). Conserved hypothetical protein, strong similarity to AL0209|SC4H8.10 hypothetical protein from Streptomyces coelicolor (132 aa), FASTA scores: opt: 429, E(): 5.2e-23, (57.1% identity in 119 aa overlap). Q7U0R2 No conserved hypotheticals Rv1066 NC_002945.3 Mycobrowser_v2 CDS 1179844 1181025 . + 0 Mb1086 CONSERVED HYPOTHETICAL PROTEIN Mb1086, -, len: 393 aa. Equivalent to Rv1057, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Conserved hypothetical protein, some similarity to X84710|MMSAG_1 surface antigen of Methanosarcina mazeii (491 aa), FASTA scores: opt: 363,E():6.2e-15, (31.3% identity in 294 aa overlap). Q7U0R9 No conserved hypotheticals Rv1057 NC_002945.3 Mycobrowser_v2 CDS 2064407 2064901 . + 0 Mb1860 conserved protein Mb1860, -, len: 164 aa. Equivalent to Rv1829, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Conserved hypothetical protein, equivalent to O32917|MLCB1788.34|AL008609 Hypothetical protein from Mycobacterium leprae (164 aa),FASTA scores: opt: 1011, E(): 0, (95.1% identity in 164 aa overlap). Also present in Aquifex aeolicus, etc. Q7TZG7 No conserved hypotheticals Rv1829 NC_002945.3 Mycobrowser_v2 CDS 1181132 1182763 . + 0 Mb1087 fadD14 PROBABLE MEDIUM CHAIN FATTY-ACID-COA LIGASE FADD14 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb1087, fadD14, len: 543 aa. Equivalent to Rv1058,len: 543 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 543 aa overlap). Probable fadD14,medium-chain fatty-acid-CoA synthetase (EC 6.2.1.-),highly similar to many e.g. CAC32346.1|AL583945 putative fatty acid CoA ligase from Streptomyces coelicolor (558 aa); N-terminus of NP_419738.1|NC_002696 medium-chain-fatty-acid--CoA ligase from Caulobacter crescentus (1006 aa); Q00594|ALKK_PSEOL MEDIUM-CHAIN-FATTY-ACID--COA LIGASE (EC 6.2.1.-) from Pseudomonas oleovorans (546 aa), FASTA scores: opt: 1468,E(): 0, (41.1% identity in 538 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U0R8 No NC_002945.3 Mycobrowser_v2 CDS 1182839 1183903 . + 0 Mb1088 conserved protein Mb1088, -, len: 354 aa. Equivalent to Rv1059, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Conserved hypothetical protein, similar to Rv0926c|MTCY21C12.20c hypothetical protein from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 338, E(): 1.4e-14, (33.1% identity in 363 aa overlap). Q7U0R7 No conserved hypotheticals Rv1059 NC_002945.3 Mycobrowser_v2 CDS 1183956 1184429 . + 0 Mb1089 unknown protein Mb1089, -, len: 157 aa. Equivalent to Rv1060, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 157 aa overlap). Hypothetical unknown protein. Q7U0R6 No conserved hypotheticals Rv1060 NC_002945.3 Mycobrowser_v2 CDS 1184463 1185326 . + 0 Mb1090 conserved protein Mb1090, -, len: 287 aa. Equivalent to Rv1061, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 287 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from various bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803 (304 aa), FASTA scores: opt: 245, E(): 1.2e-09, (27.1% identity in 258 aa overlap). Q7U0R5 No conserved hypotheticals Rv1061 NC_002945.3 Mycobrowser_v2 CDS 1186189 1187271 . - 0 Mb1092c CONSERVED HYPOTHETICAL PROTEIN Mb1092c, -, len: 360 aa. Equivalent to Rv1063c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Conserved hypothetical protein, similar to P37053|YCHK_ECOLI hypothetical protein from Escherichia coli (314 aa), FASTA scores: opt: 487,E(): 7.2e-23, (32.7% identity in 321 aa overlap). Also partially similar to Rv3239c|MTCY20B11.14c. BELONGS TO THE UPF0028 (SWS) FAMILY. X2BGK7,P67099 No conserved hypotheticals Rv1063c NC_002945.3 Mycobrowser_v2 CDS 1187352 1187771 . - 0 Mb1093c lpqV possible lipoprotein lpqv Mb1093c, lpqV, len: 139 aa. Equivalent to Rv1064c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 139 aa overlap). Putative lipoprotein LpqV. Has N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. X2BGU0,P65311 No NC_002945.3 Mycobrowser_v2 CDS 1188869 1190884 . - 0 Mb1096c PE_PGRS19 pe-pgrs family protein pe_pgrs19 Mb1096c, PE_PGRS19, len: 671 aa. Equivalent to Rv1067c, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (98.5% identity in 673 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv3388|MTV004.46 from Mycobacterium tuberculosis (731 aa),FASTA scores: opt: 2227, E(): 0, (55.6% identity in 710 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1, probably fortuitous. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions each of 3 bp (ccg-* and cgc-*) and a 18 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa). Q7U0R1 No NC_002945.3 Mycobrowser_v2 CDS 1191217 1193508 . - 0 Mb1097c PE_PGRS20 pe-pgrs family protein pe_pgrs20 Mb1097c, PE_PGRS20, len: 763 aa. Similar to Rv1068c, len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, (59.8% identity in 766 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AL021897|MTV017_19 M. tuberculosis H37Rv (667 aa), FASTA scores: opt: 1875, E(): 0, (55.0% identity in 667 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). Q7U0R0 No NC_002945.3 Mycobrowser_v2 CDS 1193870 1195633 . - 0 Mb1098c conserved protein Mb1098c, -, len: 587 aa. Equivalent to Rv1069c,len: 587 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 587 aa overlap). Conserved hypothetical protein, hydrophobic regions in N-terminal domain. Similar in part to O07136|B1306.04C B1306.04c protein from Mycobacterium leprae (89 aa), FASTA scores: opt: 229, E(): 1.3e-07, (54.2% identity in 72 aa overlap). Q7U0Q9 No conserved hypotheticals Rv1069c NC_002945.3 Mycobrowser_v2 CDS 1216980 1217435 . + 0 Mb1120 celA2b PROBABLE CELLULASE CELA2B (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE) Mb1120, celA2b, len: 151 aa. Equivalent to Rv1090,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 151 aa overlap). Probable celA2b, second part of cellulase (endoglucanase) (EC 3.2.1.4), similar to C-terminus of others e.g. O08468 cellulase CEL2 from Streptomyces halstedi (377 aa), FASTA scores: opt: 554,E(): 1.2e-30, (52.0% identity in 152 aa overlap); etc. Gene appears to have been inactivated by frameshift mutations but no errors could be found that would account for this. Q7U0P2 No NC_002945.3 Mycobrowser_v2 CDS 1199516 1200733 . - 0 Mb1103c fadA3 PROBABLE BETA-KETOACYL CoA THIOLASE FADA3 Mb1103c, fadA3, len: 405 aa. Equivalent to Rv1074c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 405 aa overlap). Probable fadA3,beta-ketoacyl CoA thiolase (EC 2.3.1.-), highly similar to many involved in beta-oxidation e.g. CAB89028.1|AL353870 beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor (395 aa); P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA thiolase from Escherichia coli (401 aa), FASTA scores: opt: 1034, E(): 5.4e-56, (43.5% identity in 416 aa overlap) and X97452 acetyl-CoA acetyltransferase (thiolase) from Escherichia coli (401 aa), FASTA scores: opt: 1043, E(): 0, (43.4% identity in 415 aa overlap); Q43935|CATF_ACICA beta-ketoadipyl CoA thiolase from Acinetobacter calcoaceticus (401 aa), FASTA scores: opt: 992, E(): 0, (41.5% identity in 415 aa overlap); etc. Contains PS00737 Thiolases signature 2, and PS00445 FGGY family of carbohydrate kinases signature 2, although this is probably fortuitous. BELONGS TO THE THIOLASE FAMILY. Q7U0Q5 No NC_002945.3 Mycobrowser_v2 CDS 1195630 1196403 . - 0 Mb1099c echA8 PROBABLE ENOYL-CoA HYDRATASE ECHA8 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) Mb1099c, echA8, len: 257 aa. Equivalent to Rv1070c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Probable echA8,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to O07137|B1306.05c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (257 aa), FASTA scores: opt: 1417, E(): 0, (86.4% identity in 257 aa overlap). Also highly similar to others e.g. NP_106219.1|NC_002678 enoyl CoA hydratase from Mesorhizobium loti (257 aa); L39265|RHMRPST_2 enoyl-CoA hydratase from Rhizobium melilotii (257 aa), FASTA scores: opt: 1100, E(): 0,(66.9% identity in 257 aa overlap); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa); etc. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-CoA HYDRATASE/ISOMERASE FAMILY. TBparse score is 0.881. X2BGZ4,P64017 No NC_002945.3 Mycobrowser_v2 CDS 1196415 1197452 . - 0 Mb1100c echA9 POSSIBLE ENOYL-COA HYDRATASE ECHA9 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb1100c, echA9, len: 345 aa. Equivalent to Rv1071c,len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 345 aa overlap). Possible echA9,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (350 aa); Q19278 PROTEIN SIMILAR TO ENOYL-COA HYDRATASES from Caenorhabditis elegans (386), FASTA scores: opt: 787, E(): 0, (38.5% identity in 348 aa overlap); etc. Q7U0Q8 No NC_002945.3 Mycobrowser_v2 CDS 1197639 1198475 . + 0 Mb1101 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb1101, -, len: 278 aa. Equivalent to Rv1072, len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 278 aa overlap). Probable conserved transmembrane protein, equivalent to O07139|B1306.07|Y13803 Protein B1306.07 from Mycobacterium leprae (220 aa), FASTA scores: opt:1032, E(): 0, (75.0% identity in 220 aa overlap); and at the C-terminal end to Q50056|U1740D Mycobacterium leprae (96 aa), FASTA scores: opt: 381, E(): 1.2e-18, (71.6% identity in 81 aa overlap). Similar to Q54192|M80628|STMBLDA_1 TRANSFER RNA-LEU (BLDA) GENE AND ORF from Streptomyces griseus (293 aa), FASTA scores: opt:558, E(): 4.7e-30, (41.5% identity in 299 aa overlap). TBparse score is 0.896. Q7U0Q7 No cell wall and cell processes Rv1072 NC_002945.3 Mycobrowser_v2 CDS 1198591 1199442 . + 0 Mb1102 CONSERVED HYPOTHETICAL PROTEIN Mb1102, -, len: 283 aa. Equivalent to Rv1073, len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 283 aa overlap). Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03 Mycobacterium tuberculosis (339 aa), FASTA scores: opt: 810, E(): 0,(47.4% identity in 272 aa overlap); Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289 aa), FASTA scores: opt: 704, E(): 0, (44.4% identity in 259 aa overlap); and Rv3517, etc., and GIR10|AF002133_10 M. avium strain GIR10 (346 aa), FASTA scores: opt: 802,E(): 0, (48.1% identity in 270 aa overlap). Q7U0Q6 No conserved hypotheticals Rv1073 NC_002945.3 Mycobrowser_v2 CDS 1200786 1201730 . - 0 Mb1104c CONSERVED EXPORTED PROTEIN Mb1104c, -, len: 314 aa. Equivalent to Rv1075c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 314 aa overlap). Possibly exported protein, as it contains a N-terminal signal sequence,hydrophobic domain from aa 7-25. Similar to U15183|MLU15183_2 Mycobacterium leprae cosmid B1740 (106 aa), FASTA scores: opt: 207, E(): 1.6e-06, (42.6% identity in 101 aa overlap). Also weak similarity to many glyceraldehyde-3-phosphate dehydrogenases e.g. Q41595|G3PC_TAXBA Taxus baccata (340 aa), FASTA scores: opt: 147, E(): 0.027, (27.5% identity in 189 aa overlap). Q7U0Q4 No cell wall and cell processes Rv1075c NC_002945.3 Mycobrowser_v2 CDS 1202127 1203020 . + 0 Mb1105 lipU possible lipase lipu Mb1105, lipU, len: 297 aa. Equivalent to Rv1076,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 297 aa overlap). Putative lipU, lipase (EC 3.1.-.-), very similar to several Mycobacterium tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c (277 aa), FASTA scores: opt: 1225, E(): 0, (76.0% identity in 246 aa overlap); Rv1426c, etc. Also similar to esterases and lipases of around 300 aa e.g. Q44087 ESTERASE PRECURSOR from Acinetobacter lwoffii esterase (303), FASTA scores: opt: 427, E(): 1.9e-21, (32.5% identity in 280 aa overlap). Equivalent to AL035159|MLCB1450 _7 Mycobacterium leprae (335 aa), FASTA scores: opt: 1588, E(): 0, (79.7% identity in 296 aa overlap). Q7U0Q3 No intermediary metabolism and respiration Rv1076 NC_002945.3 Mycobrowser_v2 CDS 1203077 1204471 . + 0 Mb1106 cbs Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) Mb1106, cbs, len: 464 aa. Equivalent to Rv1077,len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 464 aa overlap). Probable cbs (previously cysM2), cystathionine beta-synthase (EC 4.2.1.22), similar throughout its length to many eukaryotic cystathionine beta-synthases e.g. P32232|CBS_RAT CYSTATHIONINE BETA-SYNTHASE (560 aa), FASTA scores: opt: 951, E(): 0, (40.2% identity in 450 aa overlap); also similar in N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 855, E(): 0, (46.8% identity in 314 overlap); and other cysteine synthase proteins e.g. Rv1336, Rv0848, etc. Contains PS00217 Sugar transport proteins signature 2 probably spurious. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Q7VEZ8 No intermediary metabolism and respiration Rv1077 NC_002945.3 Mycobrowser_v2 CDS 1204673 1205395 . + 0 Mb1107 pra Probable Proline-rich antigen homolog pra Mb1107, pra, len: 240 aa. Equivalent to Rv1078,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 240 aa overlap). Probable pra,Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1 proline rich antigen from Mycobacterium leprae (249 aa), FASTA scores: opt: 1162, E(): 3.3e-30,(64.8% identity in 253 aa overlap). Has potential hydrophobic domains. Q7U0Q2 No conserved hypotheticals Rv1078 NC_002945.3 Mycobrowser_v2 CDS 1215894 1216328 . + 0 Mb1117 PE9 pe family protein pe9 Mb1117, PE9, len: 144 aa. Equivalent to Rv1088,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Member of Mycobacterium tuberculosis PE family, similar to many others e.g. Z96071|MTCI418B_6 Mycobacterium tuberculosis cosmid (487 aa), FASTA scores: opt: 318, E(): 7.3e-14, (60.9% identity in 87 aa overlap) - except it appears to be frameshifted around codon 84. No error to account for frameshift could be found. Q7U0P5 No PE/PPE Rv1088 NC_002945.3 Mycobrowser_v2 CDS 1205427 1206593 . + 0 Mb1108 metB cystathionine gamma-synthase metb (cgs) (o-succinylhomoserine [thiol]-lyase) Mb1108, metB, len: 388 aa. Equivalent to Rv1079,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 388 aa overlap). Probable metB,cystathionine gamma-synthase (EC 4.2.99.9) (see citation below). P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE from Mycobacterium leprae (EC 4.2.1.22) (388 aa), FASTA scores: opt: 2220, E(): 0, (87.3% identity in 387 aa overlap). Also similar to other Mycobacterium tuberculosis enzymes involved in methionine synthesis e.g. Rv0391 and Rv3340. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. X2BGV2,P66876 No intermediary metabolism and respiration Rv1079 NC_002945.3 Mycobrowser_v2 CDS 1206664 1207158 . - 0 Mb1109c greA PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA (Transcript cleavage factor greA) Mb1109c, greA, len: 164 aa. Equivalent to Rv1080c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 164 aa overlap). Probable greA,transcription elongation factor G, closest to P46808|GREA_MYCLE TRANSCRIPTION ELONGATION FACTOR G from Mycobacterium leprae (202 aa), FASTA scores: opt: 1005,E(): 0, (94.5% identity in 164 aa overlap); and similar to many e.g. P21346|GREA_ECOLI from Escherichia coli (158 aa), FASTA scores: opt: 257, E(): 5.7e-10, (37.2% identity in 148 aa overlap); etc. Contains two PS00829 and one PS00830 Prokaryotic transcription elongation factors signatures 1 and 2, respectively. BELONGS TO THE GREA/GREB FAMILY. X2BH00,P64280 No NC_002945.3 Mycobrowser_v2 CDS 1207344 1207778 . - 0 Mb1110c PROBABLE CONSERVED MEMBRANE PROTEIN Mb1110c, -, len: 144 aa. Equivalent to Rv1081c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Probable conserved membrane protein, with hydrophobic stretch from aa 26 -48, highly similar to NP_302548.1|NC_002677 conserved membrane protein from Mycobacterium leprae. Q7U0Q1 No cell wall and cell processes Rv1081c NC_002945.3 Mycobrowser_v2 CDS 1207880 1208746 . + 0 Mb1111 mca Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) Mb1111, mca, len: 288 aa. Equivalent to Rv1082,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 288 aa overlap). mca, mycothiol conjugate amidase (see citation below), equivalent to NP_302547.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (290 aa), FASTA scores: opt: 1737,E(): 0, (86.4% identity in 287 aa overlap); and similar to Q54358|X79146 lmbE protein from Streptomyces lincolnensis (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins deacetylase from Mycobacterium tuberculosis (303 aa),FASTA scores: opt: 411, E(): 9.4e-20, (35.8% identity in 299 aa overlap). Q7VEZ7 No virulence, detoxification, adaptation Rv1082 NC_002945.3 Mycobrowser_v2 CDS 1230055 1230756 . + 0 Mb1130 conserved protein Mb1130, -, len: 233 aa. Equivalent to Rv1100, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 233 aa overlap). Conserved hypothetical protein, slightly similar to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 122, E(): 6.9, (27.4% identity in 135 aa overlap). Equivalent to AL049491|MLCB1222_9 Mycobacterium leprae (257 aa) (63.8% identity in 257 aa overlap). Q7U0N4 No conserved hypotheticals Rv1100 NC_002945.3 Mycobrowser_v2 CDS 1208996 1211017 . + 0 Mb1113 conserved protein Mb1113, -, len: 673 aa. Equivalent to Rv1084, len: 673 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 673 aa overlap). Conserved hypothetical protein, similar to P37512|YYAL_BACSU hypothetical protein from Bacillus subtilis (689 aa), FASTA scores: opt: 1063,E(): 0, (36.5% identity in 696 aa overlap); AE0009|AE000983_10 Archaeoglobus fulgidus section 1 (642 aa), FASTA scores: opt: 1018, E(): 0, (37.2% identity in 600 aa overlap). Also similar to AE001938|AE001938_9 Deinococcus radiodurans (690 aa), FASTA scores: opt: 1097,E(): 0, (41.6% identity in 694 aa overlap). Q7U0P9 No conserved hypotheticals Rv1084 NC_002945.3 Mycobrowser_v2 CDS 1211116 1211844 . - 0 Mb1114c POSSIBLE HEMOLYSIN-LIKE PROTEIN Mb1114c, -, len: 242 aa. Equivalent to Rv1085c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 242 aa overlap). Possible hemolysin-like protein, integral membrane protein, similar to many hemolysins, and hypothetical proteins e.g. U28375|ECU28375_49 Hypothetical protein from Escherichia coli (219 aa), FASTA scores: opt: 308, E(): 7.5e-15,(30.6% identity in 180 aa overlap); AE0011|HIAE001124_2 Hypothetical protein from Borrelia burgdorferi (233 aa),FASTA scores: opt: 305, E(): 1.3e-14, (25.6% identity in 203 aa overlap). Also weakly similar to HLY3_BACCE|P54176 haemolysin from Bacillus cereus (219 aa), FASTA scores: opt: 247, E(): 8.7e-12, (27.5% identity in 171 aa overlap). Also similar to AE002027|AE002027_8 probable hemolysin from Deinococcus radiodurans (219 aa), FASTA scores: opt: 354, E(): 1.8e-16, (31.1% identity in 219 aa overlap). X2BH03,P67158 No virulence, detoxification, adaptation Rv1085c NC_002945.3 Mycobrowser_v2 CDS 1211955 1212743 . + 0 Mb1115 SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) (Z-FPP SYNTHETASE) (Z-FARNESYL DIPHOSPHATE SYNTHETASE) (GERANYLTRANSTRANSFERASE) (FARNESYL PYROPHOSPHATE SYNTHETASE) Mb1115, -, len: 262 aa. Equivalent to Rv1086, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 262 aa overlap). Short (C15) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.10) (see citations below), equivalent to NP_302598.1|NC_002677 possible undecaprenyl pyrophosphate synthetase from Mycobacterium leprae (262 aa), similar to many hypothetical proteins and several potential members of the upp synthase family e.g. NP_296167.1|NC_001263 undecaprenyl diphosphate synthase from Deinococcus radiodurans (339 aa); P20182|YT14_STRFR Hypothetical protein from Streptomyces fradiae (259 aa), FASTA scores: opt: 840, E(): 0, (51.0% identity in 259 aa overlap); and P38118|YARF_CORGL Hypothetical protein from Corynebacterium glutamicicum (234 aa), FASTA scores: opt: 729, E(): 0, (56.0% identity in 209 aa overlap); etc. Also similar to Rv2361c|MTCY27.19 (296 aa) (35.6% identity in 233 aa overlap). Contains PS01066 Uncharacterized protein family UPF0015 signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY. X2BH82,Q7U0P8 No cell wall and cell processes Rv1086 NC_002945.3 Mycobrowser_v2 CDS 1212920 1215244 . + 0 Mb1116 PE_PGRS21 pe-pgrs family protein pe_pgrs21 Mb1116, PE_PGRS21, len: 774 aa. Similar to Rv1087,len: 767 aa, from Mycobacterium tuberculosis strain H37Rv,(96.8% identity in 783 aa overlap). Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv1090|AL021897|MTV017_43 Mycobacterium tuberculosis H37Rv (853 aa), FASTA scores: opt: 2819, E(): 0, (59.8% identity in 860 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1 near C -terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 3 bp (*-gcg) and 45 bp, and deletions of 18 bp and 9 bp (ggtggggcc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa). Q7U0P7 No NC_002945.3 Mycobrowser_v2 CDS 1217850 1220402 . + 0 Mb1121 PE_PGRS22 pe-pgrs family protein pe_pgrs22 Mb1121, PE_PGRS22, len: 850 aa. Equivalent to Rv1091, len: 853 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 853 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv1087|AL021897|MTV017_39 Mycobacterium tuberculosis H37Rv (767 aa), FASTA scores: opt: 2819, E(): 0, (60.0% identity in 860 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (ccggcggca-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa). Q7U0P1 No NC_002945.3 Mycobrowser_v2 CDS 1220620 1221558 . - 0 Mb1122c coaA Probable pantothenate kinase coaA (Pantothenic acid kinase) Mb1122c, coaA, len: 312 aa. Equivalent to Rv1092c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 312 aa overlap). Probable coaA,pantothenate kinase (EC 2.7.1.33), similar to many e.g. P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores :opt: 1079, E(): 0, (52.7% identity in 311 aa overlap). Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae (312 aa) (93.6% identity in 312 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.912. BELONGS TO THE PANTOTHENATE KINASE FAMILY. X2BGW8,P63811 No NC_002945.3 Mycobrowser_v2 CDS 1221946 1223226 . + 0 Mb1123 glyA1 serine hydroxymethyltransferase 1 glya1 Mb1123, glyA1, len: 426 aa. Equivalent to Rv1093,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 426 aa overlap). Probable glyA1, serine hydroxymethyltransferase 1 (EC 2.1.2.1), equivalent to AL049491|MLCB1222_16 from Mycobacterium leprae (426 aa),FASTA score: (89.9 % identity in 426 aa overlap). Also similar to many e.g. P34895|GLYA_HYPME HYPHOMICROBIUM METHYLOVORUM (434 aa), FASTA scores: opt: 1492, E(): 0,(56.8% identity in 419 aa overlap); etc. BELONGS TO THE SHMT FAMILY. Note that previously known as glyA. X2BH08,P59953 No NC_002945.3 Mycobrowser_v2 CDS 1223331 1224158 . + 0 Mb1124 desA2 POSSIBLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA2 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) Mb1124, desA2, len: 275 aa. Equivalent to Rv1094,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Possible desA2,acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.19.2), equivalent to AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa),FASTA score: (78.1% identity in 274 aa overlap). Also weakly similar to plant stearoyl-acyl carrier protein desaturases, and very similar to U49839|MTV043.16C|Rv0824c enzyme desA1 from Mycobacterium tuberculosis (338 aa),FASTA scores: opt: 525, E(): 8.5e-30, (32.2% identity in 270 aa overlap); and to U15182|MLU15182_32 acyl-carrier protein desaturase precursor from Mycobacterium leprae (338 aa), FASTA scores: opt: 506, E(): 1.9e-28, (34.1% identity in 261 aa overlap). TBparse score is 0.894. Q7U0P0 No NC_002945.3 Mycobrowser_v2 CDS 1224369 1225670 . + 0 Mb1125 phoH2 PROBABLE PHOH-LIKE PROTEIN PHOH2 (PHOSPHATE STARVATION-INDUCIBLE PROTEIN PSIH) Mb1125, phoH2, len: 433 aa. Equivalent to Rv1095,len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 433 aa overlap). Probable phoH2,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein. Equivalent to AL049491 MLCB1222_14 Mycobacterium leprae (433 aa) (92.8% identity in 432 aa overlap). Similar to many proteins described as PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442 aa), FASTA scores: opt: 605, E(): 0, (40.1% identity in 444 aa overlap); or Mycobacterium tuberculosis Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352 aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOH FAMILY. Q7U0N9 No NC_002945.3 Mycobrowser_v2 CDS 1225757 1226632 . + 0 Mb1126 POSSIBLE GLYCOSYL HYDROLASE Mb1126, -, len: 291 aa. Equivalent to Rv1096, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 291 aa overlap). Possible glycosyl hydrolase (EC 3.-.-.-), possibly a deacetylase or esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3% identity in 289 aa overlap). Similar at the C-terminus of enzymes involved in carbohydrate degradation including Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog yjeA from Bacillus subtilis (467 aa), FASTA scores: opt: 418, E(): 2.6e-17, (38.6% identity in 184 aa overlap); M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces lividans (335 aa), FASTA scores: opt: 371, E(): 1.1e-14, (31.6% identity in 237 aa overlap); NP_345933.1|NC_003028 peptidoglycan N-acetylglucosamine deacetylase A from Streptococcus pneumoniae (463 aa); etc. Has possible N-terminal signal sequence with TMhelix at aa 13-31. Q7U0N8 No intermediary metabolism and respiration Rv1096 NC_002945.3 Mycobrowser_v2 CDS 1226635 1227516 . - 0 Mb1127c PROBABLE MEMBRANE GLYCINE AND PROLINE RICH PROTEIN Mb1127c, -, len: 293 aa. Equivalent to Rv1097c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 293 aa overlap). Probable membrane Gly-, Pro-rich protein, similar to Mycobacterium tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA scores: opt: 219, E(): 0.023, (30.5% identity in 266 aa overlap); and Rv2507. Contains potential membrane spanning region (aa ~68-92). TBparse score is 0.912. Q7U0N7 No cell wall and cell processes Rv1097c NC_002945.3 Mycobrowser_v2 CDS 1227513 1228937 . - 0 Mb1128c fum PROBABLE FUMARASE FUM (Fumarate hydratase) Mb1128c, fum, len: 474 aa. Equivalent to Rv1098c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 474 aa overlap). Probable fum, fumarase (EC 4.2.1.2). Equivalent to AL049491|MLCB1222_11 Mycobacterium leprae (474 aa) (89.5 % identity in 467 aa overlap). Similar to many e.g. P14408|FUMH_RAT FUMARATE HYDRATASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus (507 aa), FASTA scores: opt: 1427, E(): 0, (52.3% identity in 461 aa overlap); and P05042|FUMC_ECOLI Fumarate hydratase class II from Escherichia coli (467 aa), FASTA scores: opt: 1355, E(): 0, (50.2% identity in 444 aa overlap). Contains PS00163 Fumarate lyases signature. TBparse score is 0.886. X2BH10,Q7U0N6 No NC_002945.3 Mycobrowser_v2 CDS 1228968 1229954 . - 0 Mb1129c glpx fructose 1,6-bisphosphatase glpx Mb1129c, -, len: 328 aa. Equivalent to Rv1099c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 328 aa overlap). Conserved hypothetical protein, highly similar to P44811|GLPX_HAEIN GLPX PROTEIN HOMOLOG (believed to be involved in glycerol metabolism) (333 aa), FASTA scores: opt: 763, E():0, (46.2% identity in 327 aa overlap); and Q03224|YWJI_BACSU hypothetical protein from Bacillus subtilis (321aa ), FASTA scores: opt: 1092, E(): 0, (52.1% identity in 313 aa overlap). Equivalent to AL049491|MLCB1222_10 Mycobacterium leprae (355 aa), (93.0% identity in 328 aa overlap). X2BHA1,Q7U0N5 No intermediary metabolism and respiration Rv1099c NC_002945.3 Mycobrowser_v2 CDS 1230763 1231791 . - 0 Mb1131c CONSERVED MEMBRANE PROTEIN Mb1131c, -, len: 342 aa. Equivalent to 3' end of Rv1101c, len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 342 aa overlap). Conserved membrane protein, shows some similarity to other bacterial proteins e.g. P77406|PERM_ECOLI PUTATIVE PERMEASE PERM from Escherichia coli (353 aa), FASTA scores: opt: 287, E(): 8.8e-12, (24.9% identity in 349 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U0N3 No NC_002945.3 Mycobrowser_v2 CDS 1232031 1232342 . - 0 Mb1132c mazf3 toxin mazf3 Mb1132c, -, len: 103 aa. Equivalent to Rv1102c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 103 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protens e.g. Rv1942c|MTCY9F9_22 (109 aa),FASTA scores: opt: 158, E(): 3.6e-05, (33.3% identity in 93 aa overlap); Rv0659c|MTCI376_17 (102aa), opt: 140, E(): 0.00072, (40.6% identity in 69aa overlap); and Rv1495. Q7U0N2 No virulence, detoxification, adaptation Rv1102c NC_002945.3 Mycobrowser_v2 CDS 1232342 1232662 . - 0 Mb1133c maze3 possible antitoxin maze3 Mb1133c, -, len: 106 aa. Equivalent to Rv1103c,len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 106 aa overlap). Conserved hypothetical protein, similar to part of Mycobacterium tuberculosis hypothetical protein Rv2472|AL021246|MTV008_27 Mycobacterium tuberculosis (97 aa), FASTA score: opt: 135,E(): 0.0091, (45.8% identity in 72 aa overlap). TBparse score is 0.916. Q7U0N1 No virulence, detoxification, adaptation Rv1103c NC_002945.3 Mycobrowser_v2 CDS 1232672 1233361 . + 0 Mb1134 POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) Mb1134, -, len: 229 aa. Equivalent to Rv1104, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 229 aa overlap). Possible para-nitrobenzyl esterase (fragment; possibly first part) (EC 3.1.1.-). Similar to the N-terminal domain of many e.g. P37967|PNBA_BACSU Bacillus subtilis (489 aa), FASTA scores: opt: 715, E(): 0, (53.4% identity in 191 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing in MTV017.58|Rv1105. Q7U0N0 No intermediary metabolism and respiration Rv1104 NC_002945.3 Mycobrowser_v2 CDS 1233682 1234197 . + 0 Mb1135 POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) Mb1135, -, len: 171 aa. Equivalent to Rv1105, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Possible para-nitrobenzyl esterase (fragment; possibly second part) (EC 3.1.1.-). Similar to C-terminal domain of many e.g. P71048 PARA-NITROBENZYL ESTERASE from Bacillus subtilis (489 aa), FASTA scores: opt: 248, E(): 2.7e-10, (32.3% identity in 167 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing from MTV017.57|Rv1104. Start changed since first submission. Q7U0M9 No intermediary metabolism and respiration Rv1105 NC_002945.3 Mycobrowser_v2 CDS 2065193 2065870 . + 0 Mb1861 CONSERVED HYPOTHETICAL PROTEIN Mb1861, -, len: 225 aa. Equivalent to Rv1830, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein MLCB1788.33c|AL008609|O32916 (231 aa), FASTA scores: opt: 1307, E(): 0, (89.6% identity in 231 aa overlap). X2BJB4,P67672 No conserved hypotheticals Rv1830 NC_002945.3 Mycobrowser_v2 CDS 1238580 1239563 . - 0 Mb1141c CONSERVED HYPOTHETICAL PROTEIN Mb1141c, -, len: 327 aa. Equivalent to Rv1111c,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 327 aa overlap). Conserved hypothetical protein, N-terminal domain is hydrophobic, C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. Q7U0M6 No conserved hypotheticals Rv1111c NC_002945.3 Mycobrowser_v2 CDS 1234215 1235327 . - 0 Mb1136c 3-beta-hydroxysteroid dehydrogenase Mb1136c, -, len: 370 aa. Equivalent to Rv1106c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 370 aa overlap). Probable cholesterol dehydrogenase (EC 1.1.1.-). Equivalent to AL049491|MLCB1222_7 Mycobacterium leprae (376 aa ) (75.5% identity in 375 aa overlap). Highly similar to Q03704 NAD(P)-dependent cholesterol dehydrogenase from Nocardia sp. (364 aa), FASTA scores: opt: 1789, E(): 0, (74.5% identity in 361 aa overlap). Also similar to U32426|MCU32426_1 3-beta-hydroxy-Delta5-steroid dehydrogenase from Molluscum contagiosum virus (354 aa),FASTA scores: opt: 432, E(): 1.7e-22, (34.6% identity in 347 aa overlap). Also similar to series of Mycobacterium tuberculosis hypothetical proteins described as sugar epimerases or dehydratases e.g. Rv3634c, Rv3784, Rv3464,etc. Q7U0M8 No intermediary metabolism and respiration Rv1106c NC_002945.3 Mycobrowser_v2 CDS 1235337 1235594 . - 0 Mb1137c xseB Probable exodeoxyribonuclease VII (small subunit) xseB (Exonuclease VII small subunit) Mb1137c, xseB, len: 85 aa. Equivalent to Rv1107c,len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 85 aa overlap). Probable xseB,exonuclease VII small subunit (EC 3.1.11.6). Equivalent to AL049491|MLCB1222_6 Mycobacterium leprae (87 aa) (77.9% identity in 68 aa overlap). Similar to P43914|EX7S_HAEIN EXODEOXYRIBONUCLEASE SMALL SUBUNIT from H. influenzae (84 aa), FASTA scores: opt: 126, E(): 0.006, (37.3% identity in 67 aa overlap); and P22938|EX7S_ECOLI EXODEOXYRIBONUCLEASE SMALL SUBUNIT from Escherichia coli (79 aa), FASTA scores: opt: 125, E(): 0.0067, (39.7% identity in 58 aa overlap). BELONGS TO THE XSEB FAMILY. X2BGY7,P67457 No NC_002945.3 Mycobrowser_v2 CDS 1235584 1236831 . - 0 Mb1138c xseA PROBABLE EXODEOXYRIBONUCLEASE VII (LARGE SUBUNIT) XSEA (EXONUCLEASE VII LARGE SUBUNIT) Mb1138c, xseA, len: 415 aa. Equivalent to Rv1108c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). Probable xseA,exodeoxyribonuclease VII large subunit (EC 3.1.11.6) (see first citation below). Equivalent to AL049491|MLCB1222_5 Mycobacterium leprae (428 aa) (81.5% identity in 411 aa overlap). Similar to many e.g. P04994|EX7L_ECOLI exodeoxyribonuclease large subunit from Escherichia coli (456 aa), FASTA scores: opt: 581, E(): 1.6 e-30, (30.8% identity in 425 aa overlap); also similar to the exodeoxyribonuclease in Bacillus subtilis, H. influenzae and H. pylori. TBparse score is 0.890. BELONGS TO THE XSEA FAMILY. X2BH15,P67448 No NC_002945.3 Mycobrowser_v2 CDS 1236828 1237466 . - 0 Mb1139c conserved protein Mb1139c, -, len: 212 aa. Equivalent to Rv1109c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 212 aa overlap). Conserved hypothetical protein, N-terminal domain is hydrophobic, C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. TBparse score is 0.934. Q7U0M7 No conserved hypotheticals Rv1109c NC_002945.3 Mycobrowser_v2 CDS 1237556 1238563 . + 0 Mb1140 lytB2 PROBABLE LYTB-RELATED PROTEIN LYTB2 Mb1140, lytB2, len: 335 aa. Equivalent to Rv1110,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 335 aa overlap). Probable lytB2,LytB-related protein, equivalent to AL049491|MLCB1222_3 from Mycobacterium leprae (335 aa), FASTA score: (82.9% identity in 333 aa overlap). Also similar to LytB proteins from many bacteria (appears to have N-terminal extension) e.g. P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB PROTEIN from Escherichia coli strains K12 and O157:H7 (316 aa),FASTA scores: opt: 1041, E():0, (52.4% identity in 309 aa overlap); etc. Also very similar to another LytB-related protein from Mycobacterium tuberculosis: LytB1|Rv3382c|MTV004.40c (329 aa), FASTA scores: opt: 975,E(): 0, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY. X2BH45,P0A5I1 No NC_002945.3 Mycobrowser_v2 CDS 1239626 1240699 . + 0 Mb1142 Probable GTP binding protein Mb1142, -, len: 357 aa. Equivalent to Rv1112, len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 357 aa overlap). Probable GTP binding protein, similar to YCHF_HAEIN|P44681 probable gtp-binding protein (362 aa), FASTA scores: opt: 1189, E(): 0, (52.7% identity in 357 aa overlap). Equivalent to AL049491|MLCB1222_1 hypothetical protein from Mycobacterium leprae (356 aa) (85.9% identity in 354 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7VEZ6 No conserved hypotheticals Rv1112 NC_002945.3 Mycobrowser_v2 CDS 1240787 1240984 . + 0 Mb1143 vapb32 possible antitoxin vapb32 Mb1143, -, len: 65 aa. Equivalent to Rv1113, len: 65 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 65 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2758c|AL00896 7|MTV002.23 (88 aa) FASTA scores: opt: 97, E(): 0.86, (33.3% identity in 69 aa overlap). Part of family including Rv2871, Rv1241, Rv2132,Rv3321c, etc. Q7U0M5 No virulence, detoxification, adaptation Rv1113 NC_002945.3 Mycobrowser_v2 CDS 1240981 1241355 . + 0 Mb1144 vapc32 possible toxin vapc32. contains pin domain. Mb1144, -, len: 124 aa. Equivalent to Rv1114, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Conserved hypothetical protein, slight similarity to Mycobacterium tuberculosis hypothetical proteins MTCY159.08c (33.0% identity in 115 aa overlap); Rv1561 and Rv2010. Q7U0M4 No virulence, detoxification, adaptation Rv1114 NC_002945.3 Mycobrowser_v2 CDS 1241558 1242256 . + 0 Mb1145 POSSIBLE EXPORTED PROTEIN Mb1145, -, len: 232 aa. Equivalent to Rv1115, len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 232 aa overlap). Possible exported protein, contains possible N-terminal signal sequence. Q7U0M3 No cell wall and cell processes Rv1115 NC_002945.3 Mycobrowser_v2 CDS 1242374 1242559 . + 0 Mb1146 HYPOTHETICAL PROTEIN Mb1146, -, len: 61 aa. Equivalent to Rv1116, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 61 aa overlap). Hypothetical unknown protein. Q7U0M2 No conserved hypotheticals Rv1116 NC_002945.3 Mycobrowser_v2 CDS 1242486 1242761 . - 0 Mb1147c CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) Mb1147c, -, len: 91 aa. Equivalent to Rv1116A, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 91 aa overlap). Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of Rv1646|Z85982_9 from Mycobacterium tuberculosis (310 aa),FASTA scores: opt: 301, E(): 9.3e-13, (68.05% identity in 72 aa overlap). Also overlaps gene on other strand,Rv1116, at 3'-end. Q7U0M1 No conserved hypotheticals Rv1116A NC_002945.3 Mycobrowser_v2 CDS 1244381 1244875 . - 0 Mb1151c CONSERVED HYPOTHETICAL PROTEIN Mb1151c, -, len: 164 aa. Equivalent to Rv1120c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Conserved hypothetical protein, some similarity at C-terminus to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1890c|MTCY180.28 (462 aa), FASTA scores: opt: 187, E(): 2.2e-05, (36.6% identity in 93 aa overlap) and Rv2488c|YZ19_MYCTU|Q10551 (285 aa), FASTA scores: opt: 156, E(): 0.00074, (32.7% identity in 107 aa overlap). Q7U0L8 No conserved hypotheticals Rv1120c NC_002945.3 Mycobrowser_v2 CDS 2186604 2186981 . - 0 Mb1978c maze5 possible antitoxin maze5 Mb1978c, -, len: 125 aa. Equivalent to Rv1943c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Conserved hypothetical protein, showing some similarity with Rv1946c|MTCY09F9.18|lppG possible conserved lipoprotein from Mycobacterium tuberculosis (150 aa), FASTA score: (71.4% identity in 28 aa overlap). Q7TZ89 No virulence, detoxification, adaptation Rv1943c NC_002945.3 Mycobrowser_v2 CDS 1252988 1254343 . - 0 Mb1159c CONSERVED HYPOTHETICAL PROTEIN Mb1159c, -, len: 451 aa. Equivalent to Rv1128c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 451 aa overlap). Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc. Q7U0L1 No insertion seqs and phages Rv1128c NC_002945.3 Mycobrowser_v2 CDS 1245078 1246478 . + 0 Mb1152 zwf1 PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF1 (G6PD) Mb1152, zwf1, len: 466 aa. Equivalent to Rv1121,len: 466 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 466 aa overlap). Probable zwf1,glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), highly similar to many e.g. G6PD_E COLI|P22992 Escherichia coli (491 aa), FASTA scores: opt: 642, E(): 0, (35.8% identity in 478 aa overlap). Mycobacterium tuberculosis has two genes for ZWF, this one is highly divergent. BELONGS TO THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY. Note that previously known as zwf. X2BH05,P0A587 No intermediary metabolism and respiration Rv1121 NC_002945.3 Mycobrowser_v2 CDS 1246500 1247522 . + 0 Mb1153 gnd2 probable 6-phosphogluconate dehydrogenase,decarboxylating gnd2 Mb1153, gnd2, len: 340 aa. Equivalent to Rv1122,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 340 aa overlap). Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44), highly similar to Q53917 6-PHOSPHOGLUCONATE DEHYDROGENASE from Streptomyces coelicolor (291 aa), fasta scores: opt: 431, E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive organisms. BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY. Q7U0L7 No intermediary metabolism and respiration Rv1122 NC_002945.3 Mycobrowser_v2 CDS 1247515 1248423 . - 0 Mb1154c bpoB POSSIBLE PEROXIDASE BPOB (NON-HAEM PEROXIDASE) Mb1154c, bpoB, len: 302 aa. Equivalent to Rv1123c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 302 aa overlap). Possible bpoB,peroxidase (non-haem peroxidase) (EC 1.11.1.-), with some similarity to a range of enzymes from several organisms including: DEH1_MORSP|Q01398 haloacetate dehalogenase (EC 3.8.1.3) from Moraxella sp. (294 aa), FASTA scores: opt: 201, E(): 2.1e-06, (35.8% identity in 134 aa overlap); and BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 (EC 1.11.1.-) from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 187, E(): 1.6e-05, (23.1% identity in 281 aa overlap). Similar to several other Mycobacterium tuberculosis proteins, probable epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c,Rv3171c, etc. Contains PS00216 Sugar transport proteins signature 1. Q7U0L6 No NC_002945.3 Mycobrowser_v2 CDS 1248498 1249448 . + 0 Mb1155 ephC PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE) Mb1155, ephC, len: 316 aa. Equivalent to Rv1124,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 316 aa overlap). Probable ephC, epoxide hydrolase (EC 3.3.2.3) (see citation below), similar to Q42566 epoxide hydrolase from Arabidopsis thaliana (321 aa), FASTA scores: opt: 298, E(): 8.2e-13, (27.6% identity in 333 aa overlap). Similar to other Mycobacterium tuberculosis epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3670, Rv3473c,etc. Q7U0L5 No virulence, detoxification, adaptation Rv1124 NC_002945.3 Mycobrowser_v2 CDS 1249453 1250697 . + 0 Mb1156 CONSERVED HYPOTHETICAL PROTEIN Mb1156, -, len: 414 aa. Equivalent to Rv1125, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 414 aa overlap). Conserved hypothetical protein. Similar to AL133278|SCM11.13 hypothetical protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 182, E(): 0.0005, (28.1% identity in 437 aa overlap). Q7U0L4 No conserved hypotheticals Rv1125 NC_002945.3 Mycobrowser_v2 CDS 1250701 1251306 . - 0 Mb1157c conserved protein Mb1157c, -, len: 201 aa. Equivalent to Rv1126c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Conserved hypothetical protein, similar in N-terminus to O05567|MLCB33.17 hypothetical protein from Mycobacterium leprae (141 aa),FASTA scores: opt: 332, E(): 1.4e-23, (58.4% identity in 101 aa overlap). Q7U0L3 No conserved hypotheticals Rv1126c NC_002945.3 Mycobrowser_v2 CDS 1251303 1252775 . - 0 Mb1158c ppdK PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK Mb1158c, ppdK, len: 490 aa. Equivalent to Rv1127c,len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 490 aa overlap). Probable ppdK,Pyruvate, phosphate dikinase (EC 2.7.9.1). Equivalent (but shorter) to Z94723|MLCB33_16 ppdK from Mycobacterium leprae (601 aa) (71.8% identity in 478 aa overlap). Highly similar to N-terminus of PODK_CLOSY|P22983 pyruvate,phosphate dikinase from Clostridium symbiosum (873 aa),FASTA scores: opt: 786, E(): 0, (37.4% identity in 514 aa overlap). Q7U0L2 No NC_002945.3 Mycobrowser_v2 CDS 1254445 1255905 . - 0 Mb1160c PROBABLE TRANSCRIPTIONAL REGULATOR PROTEIN Mb1160c, -, len: 486 aa. Equivalent to Rv1129c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 486 aa overlap). Possible transcriptional regulator protein, similar to Rv0465c|MTV038.09c Mycobacterium tuberculosis (474 aa),FASTA scores: E(): 0, (47.4% identity in 468 aa overlap). Helix turn helix motif present from aa 32-53. Q7U0L0 No regulatory proteins Rv1129c NC_002945.3 Mycobrowser_v2 CDS 1255926 1257506 . + 0 Mb1161 prpd possible methylcitrate dehydratase prpd Mb1161, -, len: 526 aa. Equivalent to Rv1130, len: 526 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 526 aa overlap). Conserved hypothetical protein, some similarity to AP000063|AP000063_192 hypothetical protein from Aeropyrum pernix (479 aa), FASTA scores: opt: 717, E(): 0, (34.3% identity in 443 a a overlap), and to PRPD_ECOLI|P77243 prpd protein from Escherichia coli (483aa), FASTA scores: opt: 234, E(): 3.3e-08, (27.0% identity in 429 aa overlap). Q7U0K9 No intermediary metabolism and respiration Rv1130 NC_002945.3 Mycobrowser_v2 CDS 1257503 1258684 . + 0 Mb1162 prpc probable methylcitrate synthase prpc Mb1162, gltA1, len: 393 aa. Equivalent to Rv1131,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Probable gltA1, citrate synthase 1 (EC 4.1.3.7), highly similar to CISY_MYCSM|P26491 citrate synthase from Mycobacterium smegmatis (375 aa), FASTA scores: opt:1942, E(): 0, (80.0% identity in 375 aa overlap). Also similar to two other M. tuberculosis citrate synthases, Rv0896c|MTCY31.24|gltA2 (431 aa), FASTA score: (33.1% identity in 381 aa overlap) and Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (31.8% identity in 371 aa overlap). Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY. Q7U0K8 No NC_002945.3 Mycobrowser_v2 CDS 1258696 1260426 . + 0 Mb1163 CONSERVED MEMBRANE PROTEIN Mb1163, -, len: 576 aa. Equivalent to Rv1132, len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 576 aa overlap). Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa), fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap). Q7U0K7 No cell wall and cell processes Rv1132 NC_002945.3 Mycobrowser_v2 CDS 1269574 1270380 . - 0 Mb1173c echA11 PROBABLE ENOYL-COA HYDRATASE ECHA11 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb1173c, echA11, len: 268 aa. Equivalent to Rv1141c, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 268 aa overlap). Probable echA11, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. P24162|ECHH_RHOCA PROBABLE ENOYL-COA HYDRATASE from Rhodobacter capsulatus (257 aa); CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa), FASTA scores: opt: 513, E(): 1e-25, (36.1% identity in 249 aa overlap); etc. Also similarity with naphthoate synthases. Also highly similar to downstream ORF Rv1142c|MTCI65.09|echA10 PROBABLE ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (268 aa), FASTA scores: opt: 1225, E(): 0, (72.3% identity in 267 aa overlap). Q7U0J8 No lipid metabolism Rv1141c NC_002945.3 Mycobrowser_v2 CDS 1260438 1262717 . - 0 Mb1164c metE PROBABLE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE METE (methionine synthase, vitamin-B12 independent isozyme) Mb1164c, metE, len: 759 aa. Equivalent to Rv1133c,len: 759 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 759 aa overlap). Probable metE,5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14), highly similar to others e.g. METE_ECOLI|P25665 Escherichia coli (752 aa), FASTA scores: opt: 2251, E(): 0, (48.1% identity in 756 aa overlap). Equivalent to Z94723|MLCB33_14 metE from M. leprae (760 aa) (85.3% identity in 755 aa overlap). BELONGS TO THE VITAMIN-B12 INDEPENDENT METHIONINE SYNTHASE FAMILY. X2BHF0,P65341 No NC_002945.3 Mycobrowser_v2 CDS 1263643 1265499 . - 0 Mb1166c PPE16 ppe family protein ppe16 Mb1166c, PPE16, len: 618 aa. Equivalent to Rv1135c,len: 618 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 618 aa overlap). Member of the M. tuberculosis PPE family of glycine-rich proteins. Similar to Rv2356c (59.6% identity in 627 aa overlap); etc. Q7U0K5 No NC_002945.3 Mycobrowser_v2 CDS 1266843 1267859 . - 0 Mb1170c possible oxidoreductase Mb1170c, -, len: 338 aa. Equivalent to Rv1138c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 338 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to Q9EWQ8 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89, E(): 4.5e-09, (24.6% identity in 358 aa overlap). Q7U0K1 No intermediary metabolism and respiration Rv1138c NC_002945.3 Mycobrowser_v2 CDS 1267856 1268356 . - 0 Mb1171c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1171c, -, len: 166 aa. Equivalent to Rv1139c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 166 aa overlap). Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein, YBPQ (168 aa),FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740, Rv0750. Q7U0K0 No cell wall and cell processes Rv1139c NC_002945.3 Mycobrowser_v2 CDS 1268718 1269566 . + 0 Mb1172 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb1172, -, len: 282 aa. Equivalent to Rv1140, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 282 aa overlap). Probable integral membrane protein. Weak similarity in C-terminus to hypothetical Escherichia coli proteins YPRA and YPRB,possibly membrane-bound e.g. YPRA_ECOLI HYPOTHETICAL 24.3 KD PROTEIN (URF 1) (217 aa), FASTA scores: opt: 166, E(): 0.00062, (31.0% identity in 158 aa overlap). Q7U0J9 No cell wall and cell processes Rv1140 NC_002945.3 Mycobrowser_v2 CDS 2193772 2194221 . + 0 Mb1991 higa possible antitoxin higa Mb1991, -, len: 149 aa. Equivalent to Rv1956, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Possible transcriptional regulatory protein, contains probable helix-turn-helix motif at aa 52-73 (+4.78 SD). Q7TZ76 No virulence, detoxification, adaptation Rv1956 NC_002945.3 Mycobrowser_v2 CDS 1279641 1280189 . + 0 Mb1181 POSSIBLE TRANSPOSASE (FRAGMENT) Mb1181, -, len: 183 aa. Equivalent to Rv1150, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 183 aa overlap). Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of putative Mycobacterium tuberculosis IS element (308 aa), FASTA scores: opt: 959, E(): 0,(99.3% identity in 145 aa overlap). The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08. TBparse score is 0.914. No insertion seqs and phages Rv1150 NC_002945.3 Mycobrowser_v2 CDS 1270523 1271329 . - 0 Mb1174c echA10 PROBABLE ENOYL-CoA HYDRATASE ECHA10 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) Mb1174c, echA10, len: 268 aa. Equivalent to Rv1142c, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 268 aa overlap). Probable echA10, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa), FASTA scores: opt: 525, E(): 1.3e-26, (35.1% identity in 251 aa overlap); NP_420658.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (267 aa); NP_438092.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (263 aa); etc. Also similarity with naphthoate synthases. Also highly similar to upstream ORF Rv1141c|MTCI65.08c|echA11 PROBABLE ENOYL-CoA HYDRATASE from Mycobacterium tuberculosis (268 aa), FASTA score: opt: 1225, E(): 0, (72.3% identity in 267 aa overlap). TBparse score is 0.891. Q7U0J7 No lipid metabolism Rv1142c NC_002945.3 Mycobrowser_v2 CDS 1271433 1272515 . + 0 Mb1175 mcr PROBABLE ALPHA-METHYLACYL-COA RACEMASE MCR (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) Mb1175, mcr, len: 360 aa. Equivalent to Rv1143,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable mcr,alpha-methylacyl-CoA racemase (EC 5.1.99.4). Strong similarity to other alpha-methylacyl-CoA racemases and also some similarity to L-carnitine dehydratase (EC 4.2.1.89) e.g. U89905|g1552373 methylacyl-CoA racemase alpha from Norway rat (361 aa), FASTA scores: opt: 1035,E():0, (47.2% identity in 339 aa overlap). Equivalent to (but longer than) Z94723|MLCB33_13 Mycobacterium leprae (253 aa) (85.3% identity in 245 aa overlap). Also similar to Mycobacterium tuberculosis putative racemases Rv0855,Rv1866, Rv3272. Q7U0J6 No lipid metabolism Rv1143 NC_002945.3 Mycobrowser_v2 CDS 2196911 2197183 . - 0 Mb1997A vapB35 Possible antitoxin VapB35 Mb1997A, len: 90 aa. Equivalent to Rv1962A len: 90 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB35,antitoxin,part of toxin-antitoxin (TA) operon with Rv1962c, see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. Rv3385c, Rv3407, Rv0626 X2BJ65 No virulence, detoxification, adaptation Rv1962A NC_002945.3 Mycobrowser_v2 CDS 1272527 1273279 . + 0 Mb1176 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb1176, -, len: 250 aa. Equivalent to Rv1144, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 250 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. NP_104056.1|NC_002678 3-hydroxyacyl-CoA dehydrogenase type II from Mesorhizobium loti (253 aa); NP_251244.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (255 aa); AAK15008.1|AF233685_1|AF233685 short chain L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus (261 aa); HSU73514|g1778354|XH98G2 human short-chain alcohol dehydrogenase from Homo sapiens (261 aa), FASTA scores: opt: 875, E(): 0, (60.1% identity in 253 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U0J5 No intermediary metabolism and respiration Rv1144 NC_002945.3 Mycobrowser_v2 CDS 1273794 1276139 . + 0 Mb1177 mmpL13 probable conserved transmembrane transport protein mmpl13b Mb1177, mmpL13, len: 781 aa. Equivalent to Rv1145 and Rv1146, len: 303 aa and 470 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 284 aa overlap and 100% identity in 470 aa overlap). Probable mmpL13A, conserved transmembrane transport protein (see citation below), member of RND superfamily, showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. MTCY987|g1781238 from Mycobacterium tuberculosis (962 aa), FASTA scores: opt: 213, E(): 1.9e-06, (28.0% identity in 296 aa overlap); etc. Strong similarity to U92075|MMU92075_5 hypothetical protein from Mycobacterium marinum (256 aa), FASTA scores: opt: 957,E(): 0, (57.6% identity in 257 aa overlap). Should continue as mmpL13B|Rv1146, but frameshift required. Sequence has been checked and is identical in M. tuberculosis strain CDC1551, and Mycobacterium bovis strain AF2122/97 ????. BELONGS TO THE MMPL FAMILY. Probable mmpL13B, conserved transmembrane transport protein (see citation below), member of RND superfamily,showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. Q53902|C40046 antibiotic transport-associated protein from Streptomyces coelicolor (711 aa), FASTA scores: opt: 193, E(): 2.1e-05,(28.9% identity in 394 aa overlap); etc. Could be in frame with previous ORF mmpL13A|Rv1145, but no sequence error apparent to account for this; sequence is identical in Mycobacterium tuberculosis strain CDC1551. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-a) leads to a single product. Q7U0J4 No cell wall and cell processes Rv1145 NC_002945.3 Mycobrowser_v2 CDS 1276272 1276922 . + 0 Mb1178 conserved protein Mb1178, -, len: 216 aa. Equivalent to Rv1147, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 216 aa overlap). Conserved hypothetical protein, similar to many conserved hypothetical proteins,and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) from R. sphaeroides (203 aa), FASTA scores: opt: 156, E( ): 0.00073, (27.6% identity in 156 aa overlap). Q7U0J3 No conserved hypotheticals Rv1147 NC_002945.3 Mycobrowser_v2 CDS 1277672 1279120 . - 0 Mb1179c CONSERVED HYPOTHETICAL PROTEIN Mb1179c, -, len: 482 aa. Equivalent to Rv1148c,len: 482 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 482 aa overlap). Conserved hypothetical ORF in REP13E12 degenerate repeat, nearly identical to other hypothetical Mycobacterium tuberculosis proteins in REP13E12 repeats, although similarity extends upstream past proposed f-Met start. Very similar to other REP13E12 proteins e.g. Rv1945, Rv3467, Rv0094c, Rv1128c etc. X2BHH0,P0A5E0 No insertion seqs and phages Rv1148c NC_002945.3 Mycobrowser_v2 CDS 1280276 1280989 . - 0 Mb1182c transcriptional regulatory protein Mb1182c, -, len: 237 aa. Equivalent to Rv1151c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 237 aa overlap). Probable transcriptional regulatory protein, similar to others AE000776|AE000776_10 Aquifex aeolicus (239 aa), FASTA scores: opt: 725, E(): 0, (46.4% identity in 237 aa overlap); ECAE0002125|g1787358 Escherichia coli (279 aa),FASTA scores: opt: 464, E(): 1.3e-23, (36.7% identity in 240 aa overlap). X2BH48,P66814 No regulatory proteins Rv1151c NC_002945.3 Mycobrowser_v2 CDS 1281027 1281392 . + 0 Mb1183 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1183, -, len: 121 aa. Equivalent to Rv1152, len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 121 aa overlap). Start uncertain. Probable transcriptional regulatory protein, some similarity to others e.g. YHCF_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR (121 aa), FASTA scores: opt: 187, E(): 1.9e-06, (34.9% identity in 106 aa overlap). TBparse score is 0.876. Helix turn helix motif from aa 42-63 (+3.10 SD). Q7U0J0 No regulatory proteins Rv1152 NC_002945.3 Mycobrowser_v2 CDS 1281370 1282218 . - 0 Mb1184c omt PROBABLE O-METHYLTRANSFERASE OMT Mb1184c, omt, len: 282 aa. Equivalent to Rv1153c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 282 aa overlap). Probable omt,O-methyltransferase (EC 2.1.1-), similar to TCMP_STRGA|P39887 Tetracenomycin polyketide synthesis O-methyltransferase tcmP (EC 2.1.1.-) from Streptomyces glaucescens (270 aa), FASTA scores: opt: 368, E(): 1.7e-17, (31.3% identity in 233 aa overlap). Q7U0I9 No NC_002945.3 Mycobrowser_v2 CDS 1300139 1300681 . - 0 Mb1200c PPE17b PPE FAMILY PROTEIN [SECOND PART] Mb1200c, PPE17b, len: 181 aa. Equivalent to 3' end of Rv1168c, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b. No NC_002945.3 Mycobrowser_v2 CDS 1282801 1283244 . + 0 Mb1186 possible pyridoxamine 5'-phosphate oxidase (pnp/pmp oxidase) (pyridoxinephosphate oxidase) (pnpox) (pyridoxine 5'-phosphate oxidase) Mb1186, -, len: 147 aa. Equivalent to Rv1155, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 147 aa overlap). Conserved hypothetical protein. Similar to other hypothetical proteins e.g. AL079356|SC6G9.20 Streptomyces coelicolor (144 aa), FASTA scores: opt: 478, E(): 2.8e-26, (55.7% identity in 140 aa overlap); and Mycobacterium tuberculosis proteins Rv1875,Rv0121c, Rv2074. Q7U0I7 No intermediary metabolism and respiration Rv1155 NC_002945.3 Mycobrowser_v2 CDS 1283402 1283590 . + 0 Mb1186A HYPOTHETICAL PROTEIN Mb1186A, -, len: 62 aa. Equivalent to hypothetical protein MT1190 from Mycobacterium tuberculosis strain CDC1551 (100% identity with 62 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al.,2013). Mb1186A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BH54 No NC_002945.3 Mycobrowser_v2 CDS 1283678 1284265 . + 0 Mb1187 conserved protein Mb1187, -, len: 195 aa. Equivalent to Rv1156, len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 195 aa overlap). Conserved hypothetical protein, highly similar to CAC32318.1|AL583944 conserved hypothetical protein from Streptomyces coelicolor (197 aa). Q7U0I6 No conserved hypotheticals Rv1156 NC_002945.3 Mycobrowser_v2 CDS 1284428 1285543 . - 0 Mb1188c conserved ala-, pro-rich protein Mb1188c, -, len: 371 aa. Equivalent to Rv1157c,len: 371 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 371 aa overlap). Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. GBU04267|g451543 sea-island cotton proline-rich protein of cotton fiber (214 aa),FASTA scores: opt: 305, E(): 3.9e-05, (35.7% identity in 182 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. First start taken. Q7U0I5 No conserved hypotheticals Rv1157c NC_002945.3 Mycobrowser_v2 CDS 1285551 1286234 . - 0 Mb1189c CONSERVED HYPOTHETICAL ALA-, PRO-RICH PROTEIN Mb1189c, -, len: 227 aa. Equivalent to Rv1158c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 227 aa overlap). Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa), FASTA scores: opt: 367, E(): 1.2e-08, (36.3% identity in 212 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. Q7U0I4 No conserved hypotheticals Rv1158c NC_002945.3 Mycobrowser_v2 CDS 1286364 1287659 . + 0 Mb1190 pime mannosyltransferase pime Mb1190, -, len: 431 aa. Equivalent to Rv1159, len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 431 aa overlap). Conserved transmembrane protein, similar to others in Mycobacterium tuberculosis e.g. Rv2181|MTCY21D4.13 (560 aa), FASTA scores: opt: 172; E(): 0.00035, (25.0% identity in 332 aa overlap). Q7U0I3 No cell wall and cell processes Rv1159 NC_002945.3 Mycobrowser_v2 CDS 1287967 1288392 . + 0 Mb1192 mutT2 PROBABLE MUTATOR PROTEIN MUTT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-OXO-DGTPASE) Mb1192, mutT2, len: 141 aa. Equivalent to Rv1160,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 141 aa overlap). Probable mutT, mutator protein or homolog (EC 3.6.1.-). More similar to D908197|g1742860 MutT homolog from Escherichia coli (135 aa), FASTA scores: opt: 226, E():1.1e-08, (39.7% identity in 116 aa overlap); than to MUTT_ECOLI|P08337 MUTATOR MUTT PROTEIN from Escherichia coli (129 aa), FASTA scores: opt: 180, E(): 1.2e-05, (27.1% identity in 129 aa overlap). Contains PS00893 mutT domain signature. Q7U0I2 No NC_002945.3 Mycobrowser_v2 CDS 1288700 1292398 . + 0 Mb1193 narG respiratory nitrate reductase (alpha chain) narg Mb1193, narG, len: 1232 aa. Equivalent to Rv1161,len: 1232 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1232 aa overlap). Probable narG,respiratory nitrate reductase alpha chain (EC 1.7.99.4). Similar to others e.g. NARG_BACSU NITRATEREDUCTASE ALPHA CHAIN from Bacillus subtilis (1228 aa), FASTA scores: opt: 4218, E(): 0, (50.3% identity in 1229 aa overlap); etc. Also highly similar to N-terminal part of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE from Mycobacterium tuberculosis (85.1% identity in 281 aa overlap). Contains prokaryotic molybdopterin oxidoreductase signatures 1 and 2 (PS00551, PS00490). BELONGS TO THE PROKARYOTIC MOLYBDOPTERIN-CONTAINING OXIDOREDUCTASE FAMILY. Q7U0I1 No NC_002945.3 Mycobrowser_v2 CDS 1299459 1300064 . - 0 Mb1199c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1199c, -, len: 201 aa. Equivalent to Rv1167c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Probable transcriptional regulator, similar to several e.g. D1022772|D85417 hemR from Propionibacterium freudenreichii (243 aa), FASTA scores: opt: 268, E(): 5.4e-16, (35.9% identity in 198 aa overlap) and AL022268|SC4H2.32 Streptomyces coelicolor (111 aa), FASTA scores: opt: 274,E(): 5e-11, (55.1% identity in 89 aa overlap). Q7U0H5 No regulatory proteins Rv1167c NC_002945.3 Mycobrowser_v2 CDS 1292437 1294113 . + 0 Mb1194 narH PROBABLE RESPIRATORY NITRATE REDUCTASE (BETA CHAIN) NARH Mb1194, narH, len: 558 aa. Equivalent to Rv1162,len: 558 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 558 aa overlap). Probable narH,respiratory nitrate reductase beta chain (EC 1.7.99.4). Similar to others e.g. NARH_BACSU|P42176 NITRATE REDUCTASE BETA CHAIN from Bacillus subtilis (487 aa), FASTA scores: opt: 2049, E(): 0, (56.8% identity in 488 aa overlap); etc. Contains PS00190 cytochrome c family heme-binding site signature. Q7U0I0 No intermediary metabolism and respiration Rv1162 NC_002945.3 Mycobrowser_v2 CDS 1294170 1294775 . + 0 Mb1195 narJ PROBABLE RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) NARJ Mb1195, narJ, len: 201 aa. Equivalent to Rv1163,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Probable narJ,respiratory nitrate reductase delta chain (EC 1.7.99.4). Similar to others e.g. P42178|NARJ_BACSU NITRATE REDUCTASE DELTA CHAIN from Bacillus subtilis (184 aa), FASTA scores: opt: 254, E(): 1.9e-10, (31.8% identity in 179 aa overlap); etc. Strong similarity to region from aa 260 -410 of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE from Mycobacterium tuberculosis (64.8% identity in 159 aa overlap). Q7U0H9 No intermediary metabolism and respiration Rv1163 NC_002945.3 Mycobrowser_v2 CDS 1294778 1295518 . + 0 Mb1196 narI PROBABLE RESPIRATORY NITRATE REDUCTASE (GAMMA CHAIN) NARI Mb1196, narI, len: 246 aa. Equivalent to Rv1164,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 246 aa overlap). Probable narI,respiratory nitrate reductase gamma chain (EC 1.7.99.4). Similar to others e.g. NARI_BACSU|P42177 NITRATE REDUCTASE GAMMA CHAIN from Bacillus subtilis (223 aa), FASTA scores: opt: 652, E(): 0; (41.6% identity in 221 aa overlap); etc. Highly similar to C-terminal part of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE (GAMMA CHAIN) from Mycobacterium tuberculosis (68.6% identity in 239 aa overlap). Q7U0H8 No intermediary metabolism and respiration Rv1164 NC_002945.3 Mycobrowser_v2 CDS 1295540 1297426 . + 0 Mb1197 typA POSSIBLE GTP-BINDING TRANSLATION ELONGATION FACTOR TYPA (TYROSINE PHOSPHORYLATED PROTEIN A) (GTP-BINDING PROTEIN) Mb1197, typA, len: 628 aa. Equivalent to Rv1165,len: 628 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 628 aa overlap). Possible typA (alternate gene name: bipA), GTP-binding translation elongation factor, similar to several e.g. P32132|TYPA_ECOLI|BIPA|B387 Escherichia coli (591 aa); YIHK_SYNY3|P72749 GTP-binding protein TYPA/BIPA homolog from synechocystis sp. (597 aa), FASTA scores: E(): 0,(46.9% identity in 610 aa overlap); and to elongation factor EF-G from many organims e.g. EFG_MICLU|P09952 micrococcus luteus (701 aa), FASTA scores: E(): 3e-24,(29.8% identity in 500 aa overlap). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, TYPA SUBFAMILY. Q7U0H7 No information pathways Rv1165 NC_002945.3 Mycobrowser_v2 CDS 1328939 1330555 . - 0 Mb1218c conserved protein Mb1218c, -, len: 538 aa. Equivalent to Rv1186c,len: 538 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 538 aa overlap). Conserved hypothetical protein, similar to AL117385|SC5G9.24 hypothetical protein from Streptomyces coelicolor (555 aa), FASTA scores: opt: 485, E(): 2.3e-23, (32.6% identity in 568 aa overlap). Contains helix turn helix motif from aa 488-509 (+2.81 SD). Q7U0F9 No conserved hypotheticals Rv1186c NC_002945.3 Mycobrowser_v2 CDS 1368707 1369102 . + 0 Mb1256 tatB Probable protein TatB Mb1256, tatB, len: 131 aa. Equivalent to Rv1224,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 131 aa overlap). Probable tatB,component of twin-arginine translocation protein export system (see citation below for more information). Possible exported protein with hydrophobic stretch at N-terminus. Highly similar to Q49973|U15180 hypothetical protein U1756Y from Mycobacterium leprae (120 aa), FASTA scores: opt: 601, E(): 0, (73.3% identity in 131 aa overlap). X2BHF1,Q7VEZ5 No cell wall and cell processes Rv1224 NC_002945.3 Mycobrowser_v2 CDS 1297524 1299431 . + 0 Mb1198 lpqW probable conserved lipoprotein lpqw Mb1198, lpqW, len: 635 aa. Equivalent to Rv1166,len: 635 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 635 aa overlap). Probable Lipoprotein LpqW, almost identical in part to G2384665|AF009358 Mycobacterium tuberculosis gene fragment ORFA2-898 (FRAGMENT) (59 aa) (93.9% identity in 49 aa overlap) (see citation below). Also similar to Rv1280c and Rv2585c. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U0H6 No cell wall and cell processes Rv1166 NC_002945.3 Mycobrowser_v2 CDS 1300635 1301177 . - 0 Mb1201c PPE17a PPE FAMILY PROTEIN [FIRST PART] Mb1201c, PPE17a, len: 180 aa. Similar to 5' end of Rv1168c, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, (97.1% identity in 174 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b. Q7U0H4 No NC_002945.3 Mycobrowser_v2 CDS 1301195 1301497 . - 0 Mb1202c lipx pe family protein. possible lipase lipx. Mb1202c, PE11, len: 100 aa. Equivalent to Rv1169c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 100 aa overlap). Member of the Mycobacterium tuberculosis PE family of proteins (see second citation below), e.g. O05297|Z93777|MTCI364.07 (99 aa), FASTA scores: opt: 209, E(): 1.6e-15, (37.4% identity in 99 aa overlap). Also simlar to the N-terminus of P77909|U76006 ESTERASE/LIPASE (EC 3.1.1.3) from Mycobacterium tuberculosis (437 aa), FASTA scores: opt: 193, E(): 4.4e-14, (37.2% identity in 94 aa overlap). Contains a helix-turn-helix motif from aa 88-109 (+2.76 SD). Q7U0H3 No NC_002945.3 Mycobrowser_v2 CDS 1301677 1302588 . + 0 Mb1203 mshB N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase mshB (GlcNAc-Ins deacetylase) Mb1203, mshB, len: 303 aa. Equivalent to Rv1170,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 303 aa overlap). mshB,N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyra noside Deacetylase (GlcNAc-Ins deacetylase) (see citation below), similar to Q54358|X79146 lmbE gene from Streptomyces lincolnensis (270 aa), FASTA scores: opt: 308, E(): 1.2e-15, (32.0% identity in 278 aa overlap). Also similar to Rv1082|MCA Mycothiol conjugate amidase from Mycobacterium tuberculosis (288 aa). X2BHK1,Q7U0H2 No intermediary metabolism and respiration Rv1170 NC_002945.3 Mycobrowser_v2 CDS 1304304 1306874 . + 0 Mb1206 fbiC PROBABLE F420 BIOSYNTHESIS PROTEIN FBIC Mb1206, fbiC, len: 856 aa. Equivalent to Rv1173,len: 856 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 856 aa overlap). Probable fbiC, F420 biosynthesis protein, equivalent to AAL91922|FBIC F420 biosynthesis protein fbiC from Mycobacterium bovis BCG (856 aa) (see citation below). The N-terminus (aa 80-420) is similar to Y446_METJA|Q57888 hypothetical protein mj0446 from methanococcus jannaschii (361 aa), FASTA scores: opt: 801, E(): 0, (41.2% identity in 337 aa overlap); and the C-terminus region (aa 530-856) is similar to e.g. YE31_METJA|Q58826 hypothetical protein mj1431 from methanococcus jannaschii (359 aa), FASTA scores: opt: 1089, E(): 0, (48.7% identity in 337 aa overlap). X2BH81,Q7U0G9 No intermediary metabolism and respiration Rv1173 NC_002945.3 Mycobrowser_v2 CDS 1306918 1307250 . - 0 Mb1207c tb8.4 low molecular weight t-cell antigen tb8.4 Mb1207c, -, len: 110 aa. Equivalent to Rv1174c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Hypothetical unknown protein. Q7U0G8 No cell wall and cell processes Rv1174c NC_002945.3 Mycobrowser_v2 CDS 2235000 2235344 . - 0 Mb2030c fdxA ferredoxin fdxa Mb2030c, fdxA, len: 114 aa. Equivalent to Rv2007c,len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Probable fdxA,ferredoxin, similar to e.g. FER_MYCSM P00215 ferredoxin,Mycobacterium smegmatis (106 aa), FASTA scores, opt: 448,E(): 1 .6e-21, (58.7% identity in 109 aa overlap), also similar to Rv0886|MTCY31.14, (34.2% identity in 117 aa overlap) and fdxC|Rv1177. X2BJ89,P64123 No NC_002945.3 Mycobrowser_v2 CDS 1307451 1309475 . - 0 Mb1208c fadH PROBABLE NADPH DEPENDENT 2,4-DIENOYL-COA REDUCTASE FADH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) Mb1208c, fadH, len: 674 aa. Equivalent to Rv1175c,len: 674 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 674 aa overlap). Probable fadH,NADPH-dependent 2,4-dienoyl-CoA reductase (EC 1.3.1.34),highly similar to others e.g. NP_251782.1|NC_002516 2,4-dienoyl-CoA reductase FadH1 from Pseudomonas aeruginosa (679 aa); CAC01564.1|AL391039 2,4-dienoyl-CoA reductase [NADPH] from Streptomyces coelicolor (671 aa); P42593|FADH_ECOLI 2,4-dienoyl-CoA reductase from Escherichia coli (671 aa), FASTA scores: opt: 2344, E(): 0, (53.1% identity in 671 aa overlap); etc. Also similar to Rv3359|MTV004.16 PUTATIVE OXIDOREDUCTASE from Mycobacterium tuberculosis (396 aa). Q7U0G7 No NC_002945.3 Mycobrowser_v2 CDS 1309472 1310041 . - 0 Mb1209c CONSERVED HYPOTHETICAL PROTEIN Mb1209c, -, len: 189 aa. Equivalent to Rv1176c,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 189 aa overlap). Conserved hypothetical protein, some similarity to P94443|D78508 hypothetical protein from Bacillus subtilis (182 aa), FASTA scores: opt: 219, E(): 1.7e-15, (25.1% identity in 183 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv0047c. Q7U0G6 No conserved hypotheticals Rv1176c NC_002945.3 Mycobrowser_v2 CDS 1310254 1310580 . + 0 Mb1210 fdxC PROBABLE FERREDOXIN FDXC Mb1210, fdxC, len: 108 aa. Equivalent to Rv1177,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 108 aa overlap). Probable fdxC,ferredoxin (EC 1.-.-.-), equivalent to NP_302047.1|NC_002677 ferredoxin from Mycobacterium leprae (108 aa); P00215|FER_MYCSM FERREDOXIN from Mycobacterium smegmatis (106 aa), FASTA scores: opt: 705, E(): 0, (87.7% identity in 106 aa overlap). Also highly similar to many e.g. JH0239 ferredoxin precursor from Saccharopolyspora erythraea (105 aa); P24496|FER_SACER FERREDOXIN from Saccharopolyspora erythraea (106 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. BELONGS TO THE BACTERIAL TYPE FERREDOXIN FAMILY. COFACTOR: BINDS 1 4FE-4S CLUSTER AND A 3FE-4S CLUSTER. Q7U0G5 No intermediary metabolism and respiration Rv1177 NC_002945.3 Mycobrowser_v2 CDS 1310613 1311701 . + 0 Mb1211 PROBABLE AMINOTRANSFERASE Mb1211, -, len: 362 aa. Equivalent to Rv1178, len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 362 aa overlap). Probable aminotransferase (EC 2.6.1.-), weak similarity to many aspartate aminotransferases e.g. Q55679|D64000 SLL0006 aspartate aminotransferase from Synechocystis sp. (394 aa), FASTA scores: opt: 218, E(): 1.3e-25, (32.5% identity in 379 aa overlap). Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. Also similar to Mycobacterium tuberculosis aminotransferases Rv2294,Rv0075, etc. Q7U0G4 No intermediary metabolism and respiration Rv1178 NC_002945.3 Mycobrowser_v2 CDS 1311729 1314548 . - 0 Mb1212c unknown protein Mb1212c, -, len: 939 aa. Equivalent to Rv1179c,len: 939 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 939 aa overlap). Hypothetical unknown protein. Q7U0G3 No conserved hypotheticals Rv1179c NC_002945.3 Mycobrowser_v2 CDS 1314975 1321232 . + 0 Mb1213 pks3 probable polyketide beta-ketoacyl synthase pks4 Mb1213, pks3, len: 2085 aa. Equivalent to Rv1180 and Rv1181, len: 488 aa and 1582 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 488 aa overlap and 99.9% identity in 1582 aa overlap). Probable polyketide beta-ketoacyl synthase (EC 2.3.1.-), similar to the N-terminus of many polyketide synthases e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from mycobacterium bovis (2110 aa), FASTA scores: opt: 2115,E(): 0, (66.5% identity in 472 aa overlap). Also similar to, and same length as P96284|Z83858|MTCY24G1.02 M. tuberculosis (496 aa), FASTA scores: opt: 1424, E(): 0,(50.9% identity in 444 aa overlap). Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site, also PS00606 Beta-ketoacyl synthases active site. BELONGS TO THE BETA-KETOACYL-ACP SYNTHASES FAMILY. Probable polyketide synthase, similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from mycobacterium bovis (2110 aa), FASTA scores: opt: 3518, E(): 0, (59.7% identity in 1614 aa overlap). Note that this similarity extends upstream of the first initiation codon into the upstream MTV005.16; however the stop codon at the end of MTV005.16 is present in at least 4 independent clones (BAC, cosmid and pUC) from the genome. The two CDS's may represent separate modules of the polyketide synthase. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis, a single base transversion (a-c) leads to a single product (similar to other organisms). Q7U0G2 No lipid metabolism Rv1180 NC_002945.3 Mycobrowser_v2 CDS 1321285 1322703 . + 0 Mb1214 papA3 PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3 Mb1214, papA3, len: 472 aa. Equivalent to Rv1182,len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 472 aa overlap). Probable papA3,conserved polyketide synthase (PKS) associated protein,similar to other Mycobacterial hypothetical proteins e.g. Q49618|U00010 B1170_C1_180 from Mycobacterium leprae (471 aa), FASTA scores: opt: 2526, E(): 0, (75.6% identity in 471 aa overlap). Similar to other Mycobacterium tuberculosis hypothetical papA proteins; Rv3824c, Rv3820c,Rv1528c. Q7U0G1 No NC_002945.3 Mycobrowser_v2 CDS 1322770 1325778 . + 0 Mb1215 mmpL10 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL10 Mb1215, mmpL10, len: 1002 aa. Equivalent to Rv1183,len: 1002 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1002 aa overlap). Probable mmpL10, conserved transmembrane transport protein (see first citation below), member of RND superfamily, similar to many Mycobacterial hypothetical membrane proteins e.g. Q49619|U00010 from Mycobacterium leprae (1008 aa), FASTA scores: opt: 4545, E(): 0, (70.6% identity in 978 aa overlap); etc. BELONGS TO THE MMPL FAMILY. X2BGW1,P65373 No NC_002945.3 Mycobrowser_v2 CDS 1325782 1326861 . - 0 Mb1216c POSSIBLE EXPORTED PROTEIN Mb1216c, -, len: 359 aa. Equivalent to Rv1184c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 359 aa overlap). Possible exported protein with potential N-terminal signal sequence. Similar to several Mycobacterial hypothetical proteins e.g. Q49633|U00010) Protein B1170_F3_112 from M. leprae (391 aa), FASTA scores: opt: 1422, E(): 0, (62.7% identity in 338 aa overlap). Also similar to Rv3822, Rv3539, Rv1430,Rv0151c, etc. Q7U0G0 No cell wall and cell processes Rv1184c NC_002945.3 Mycobrowser_v2 CDS 1327026 1328762 . - 0 Mb1217c fadD21 probable fatty-acid-amp ligase fadd21 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb1217c, fadD21, len: 578 aa. Equivalent to Rv1185c, len: 578 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 578 aa overlap). Probable fadD21, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to several from Mycobacteria e.g. NP_301895.1|NC_002677 possible acyl-CoA synthase from Mycobacterium leprae (579 aa); P71495|U75685 ACYL-COA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8% identity in 579 aa overlap); etc. SEEMS TO BELONG TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. X2BH57,P63524 No lipid metabolism Rv1185c NC_002945.3 Mycobrowser_v2 CDS 1370076 1371539 . - 0 Mb1258c PROBABLE TRANSMEMBRANE PROTEIN Mb1258c, -, len: 487 aa. Equivalent to Rv1226c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 487 aa overlap). Probable transmembrane protein. Some similarity to AL049841|SCE9.01 Streptomyces coelicolor (436 aa), FASTA scores: opt: 203, E(): 1.2e-05,(29.8% identity in 346 aa overlap). Q7U0C5 No cell wall and cell processes Rv1226c NC_002945.3 Mycobrowser_v2 CDS 1330640 1332271 . + 0 Mb1219 rocA PROBABLE PYRROLINE-5-CARBOXYLATE DEHYDROGENASE ROCA Mb1219, rocA, len: 543 aa. Equivalent to Rv1187,len: 543 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 543 aa overlap). Probable rocA,pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12),similar to many e.g. PUT2_HUMAN|P30038 human delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa),FASTA scores: opt: 1596, E():0, (46.0% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site. Q7U0F8 No intermediary metabolism and respiration Rv1187 NC_002945.3 Mycobrowser_v2 CDS 1342253 1342537 . + 0 Mb1230 esxL putative esat-6 like protein esxl (esat-6 like protein 4) Mb1230, esxL, len: 94 aa. Equivalent to Rv1198,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 94 aa overlap). esxL, putative ESAT-6 likeprotein 4. Member of the ESAT-6 family with Rv3619c,Rv1037c, etc. Almost identical to MTCY10G2.12 (94 aa) (97.9% identity in 94 aa overlap) and MTCY98.022c (94 aa) (94.7% identity in 94 aa overlap). Highly similar to Q49946|U1756D Mycobacterium leprae (95 aa), FASTA scores: opt: 403, E(): 1.1e-22, (64.1% identity in 92 aa overlap). X2BGY3 No cell wall and cell processes Rv1198 NC_002945.3 Mycobrowser_v2 CDS 1332271 1333260 . + 0 Mb1220 PROBABLE PROLINE DEHYDROGENASE Mb1220, -, len: 329 aa. Equivalent to Rv1188, len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 329 aa overlap). Possible putA, proline dehydrogenase (EC 1.5.99.8), similar to part of Q52711|X78346 proline dehydrogenase from Rhodobacter capsulatus (1127 aa), FASTA scores: opt: 194, E(): 1.5e-07, (31.2% identity in 349 aa overlap). Also similar to two Bacillus subtilis proline dehydrohenases E1184363|Z99120 (302 aa), FASTA scores: opt: 509, E(): 0,(37.1% identity in 313 aa overlap); and E1182272|Z99105 (303 aa), FASTA scores: opt: 513, E(): 0, (32.5% identity in 311 aa overlap). Highly similar to AL035569|SC8D9.31 Streptomyces coelicolor (308 aa), FASTA scores: opt: 984,E(): 0, (50.0% identity in 312 aa overlap). Q7U0F7 No intermediary metabolism and respiration Rv1188 NC_002945.3 Mycobrowser_v2 CDS 1507003 1507323 . + 0 Mb1379 mbtl acyl carrier protein (acp) mbtl Mb1379, -, len: 106 aa. Equivalent to Rv1344, len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 106 aa overlap). Possible acyl carrier protein, similar to others e.g. ACP_RHIME|P19372 Rhizobium meliloti (77 aa), FASTA scores: opt: 117, E(): 0.03,(29.9% identity in 67 aa overlap) and ACP_SYNY3|P20804 acyl carrier protein (acp) from Synechocystis sp (77 aa),FASTA scores: E(): 7.1e-05, (34.8% identity in 66 aa overlap). Also similar to Rv2244 and Rv0033 from Mycobacterium tuberculosis. X2BHN6,P63453 No lipid metabolism Rv1344 NC_002945.3 Mycobrowser_v2 CDS 1333342 1334214 . + 0 Mb1221 sigI POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGI Mb1221, sigI, len: 290 aa. Equivalent to Rv1189,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 290 aa overlap). Possible sigI,alternative RNA polymerase sigma factor (see citation below), similar to several e.g. O05767|U87307 extracytoplasmic function alternative sigma factor (sigE) from M. smegmatis (204 aa), FASTA scores: opt: 239, E(): 1.3e-09, (32.9% identity in 167 aa overlap). Q7U0F6 No information pathways Rv1189 NC_002945.3 Mycobrowser_v2 CDS 1334230 1335108 . + 0 Mb1222 CONSERVED HYPOTHETICAL PROTEIN Mb1222, -, len: 292 aa. Equivalent to Rv1190, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 292 aa overlap). Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kd protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap),also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). Q7U0F5 No conserved hypotheticals Rv1190 NC_002945.3 Mycobrowser_v2 CDS 1335181 1336095 . + 0 Mb1223 conserved protein Mb1223, -, len: 304 aa. Equivalent to Rv1191, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 304 aa overlap). Conserved hypothetical protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 269 aa overlap); Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): 6.6e-06, (26.4% identity in 299 aa overlap), some similarity to PIP_NEIGO|P42786 proline iminopeptidase (EC 3.4.11.5) (310 aa), FASTA scores: opt: 196, E(): 1.3e-05,(32.2% identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature. Q7U0F4 No conserved hypotheticals Rv1191 NC_002945.3 Mycobrowser_v2 CDS 1336177 1337004 . + 0 Mb1224 unknown protein Mb1224, -, len: 275 aa. Equivalent to Rv1192, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Hypothetical unknown protein, contains PS00120 lipases, serine active site. Q7U0F3 No conserved hypotheticals Rv1192 NC_002945.3 Mycobrowser_v2 CDS 1337044 1338465 . + 0 Mb1225 fadD36 PROBABLE FATTY-ACID-COA LIGASE FADD36 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb1225, fadD36, len: 473 aa. Equivalent to Rv1193,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 473 aa overlap). Probable fadD36,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa), FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U0F2 No NC_002945.3 Mycobrowser_v2 CDS 1338498 1339763 . - 0 Mb1226c conserved protein Mb1226c, -, len: 421 aa. Equivalent to Rv1194c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 421 aa overlap). Conserved hypothetical protein, highly similar to Q50018 possible transcriptional activator from Mycobacterium leprae (517 aa), FASTA scores: opt: 1960, E(): 0, (69.8% identity in 421 aa overlap). Also similar to Mycobacterium tuberculosis Rv2370c|MTCY27.10, (62.0% identity in 421 aa overlap) and Rv1453|MTCY493.01c. Q7U0F1 No conserved hypotheticals Rv1194c NC_002945.3 Mycobrowser_v2 CDS 1340253 1340552 . + 0 Mb1227 PE13 pe family protein pe13 Mb1227, PE13, len: 99 aa. Equivalent to Rv1195,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 99 aa overlap). Member of Mycobacterium tuberculosis PE family (see first citation below), e.g. Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kd protein (498 aa), FASTA scores: opt: 307, E(): 1.4e-12,(56.3% identity in 96 aa overlap), similar to MTCY21C12.10c (99 aa), FASTA scores: opt:295, E(): 1.9e-11, (51.5% identity in 97 aa overlap). Q7U0F0 No PE/PPE Rv1195 NC_002945.3 Mycobrowser_v2 CDS 1340599 1341771 . + 0 Mb1228 PPE18 ppe family protein ppe18 Mb1228, PPE18, len: 390 aa. Equivalent to Rv1196,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 391 aa overlap). PPE18 (alternate gene name: mtb39a). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to others e.g. Y07P_MYCTU|Q11031 hypothetical 40.0 kDa protein cy02b10.25c (396 aa), FASTA scores: opt: 2124,E(): 0, (85.1% identity in 397 aa overlap). Note that expression of Rv1196 was demonstrated in lysates by immunodetection (see first citation below). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa). Q7U0E9 No NC_002945.3 Mycobrowser_v2 CDS 1341906 1342202 . + 0 Mb1229 esxK esat-6 like protein esxk (esat-6 like protein 3) Mb1229, esxK, len: 98 aa. Equivalent to Rv1197,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 98 aa overlap). esxK, putative ESAT-6 like protein 3. Member of M. tuberculosis hypothetical QILSS protein family with Rv1038c, etc. Almost identical to MTCY98.023c (98 aa) (99.0% identity in 98 aa overlap) and MTCY10G2.11 (98 aa), FASTA scores: opt: 643, E(): 0,(99.0% identity in 98 aa overlap); highly similar to Q49945|U1756C from Mycobacterium leprae (100 aa), FASTA scores: opt: 377, E(): 8e-21, (58.3% identity in 96 aa overlap). BELONGS TO THE ESAT6 FAMILY. X2BGJ8 No cell wall and cell processes Rv1197 NC_002945.3 Mycobrowser_v2 CDS 1354404 1354772 . + 0 Mb1241 conserved protein Mb1241, -, len: 122 aa. Equivalent to Rv1209, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 122 aa overlap). Conserved hypothetical protein, containing a hydrophobic N-terminus. Similar to Q49956|U1756M hypothetical protein from Mycobacterium leprae (114 aa), FASTA scores: opt: 524, E(): 8.9e-29,(78.6% identity in 112 aa overlap). Q7U0E0 No conserved hypotheticals Rv1209 NC_002945.3 Mycobrowser_v2 CDS 1348183 1349871 . - 0 Mb1236c CONSERVED HYPOTHETICAL PROTEIN Mb1236c, -, len: 562 aa. Equivalent to Rv1204c,len: 562 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 562 aa overlap). Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from STREPTOMYCES SP. (642 aa), FASTA scores: opt: 215, E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A. Q7U0E4 No conserved hypotheticals Rv1204c NC_002945.3 Mycobrowser_v2 CDS 1342605 1343852 . - 0 Mb1231c POSSIBLE TRANSPOSASE Mb1231c, -, len: 415 aa. Equivalent to Rv1199c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). Possible transposase for IS1081, identical to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa); region identical to MTCY441.35 (100.0% identity in 261 aa overlap); and almost identical to MTCY10G2.02c (415 aa) (99.8% identity in 415 aa overlap). Contains PS01007 Transposases, Mutator family, signature, PS00435 Peroxidases proximal heme-ligand signature. X2BGW7,P60231 No insertion seqs and phages Rv1199c NC_002945.3 Mycobrowser_v2 CDS 1344189 1345466 . + 0 Mb1232 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Mb1232, -, len: 425 aa. Equivalent to Rv1200, len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 425 aa overlap). Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. YHJE_ECOLI|P37643 hypothetical metabolite transport protein from Escherichia coli (440 aa), FASTA scores: opt: 1047, E(): 0, (39.1% identity in 427 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2. Q7U0E8 No cell wall and cell processes Rv1200 NC_002945.3 Mycobrowser_v2 CDS 1345463 1346416 . - 0 Mb1233c dapd tetrahydrodipicolinate n-succinyltransferase dapd Mb1233c, -, len: 317 aa. Equivalent to Rv1201c,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 317 aa overlap). Probable transferase (EC 2.-.-.-). Highly similar to Q49948|U1756F Mycobacterium leprae (317 aa), FASTA scores: opt: 1776,E(): 0, (84.9% identity in 317 aa overlap), also Q46064 ORF3 protein from CORYNEBACTERIUM GLUTAMICUM (316 aa),FASTA scores: opt: 864, E(): 0, (44.1% identity in 311 aa overlap). X2BHN4,Q7U0E7 No intermediary metabolism and respiration Rv1201c NC_002945.3 Mycobrowser_v2 CDS 1346507 1347571 . + 0 Mb1234 dapE PROBABLE SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE DAPE Mb1234, dapE, len: 354 aa. Equivalent to Rv1202,len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Probable dapE,succinyl-diaminopimelate desuccinylase (EC 3.5.1.18),similar to DAPE_CORGL|Q59284 succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum (369 aa),FASTA scores: opt: 1301, E(): 0, (55.7% identity in 359 aa overlap), highly similar to Q49949|U1756G (400 aa), FASTA scores: opt: 2045, E(): 0, (87.0% identity in 354 aa overlap). Q7U0E6 No intermediary metabolism and respiration Rv1202 NC_002945.3 Mycobrowser_v2 CDS 1347568 1348152 . - 0 Mb1235c HYPOTHETICAL PROTEIN Mb1235c, -, len: 194 aa. Equivalent to Rv1203c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 194 aa overlap). Hypothetical unknown protein. Q7U0E5 No conserved hypotheticals Rv1203c NC_002945.3 Mycobrowser_v2 CDS 1378220 1378747 . + 0 Mb1266 PROBABLE TRANSMEMBRANE PROTEIN Mb1266, -, len: 175 aa. Equivalent to Rv1234, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 175 aa overlap). Possible transmembrane protein with two TM helices. Q7U0B8 No cell wall and cell processes Rv1234 NC_002945.3 Mycobrowser_v2 CDS 1349966 1350529 . + 0 Mb1237 CONSERVED HYPOTHETICAL PROTEIN Mb1237, -, len: 187 aa. Equivalent to Rv1205, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 187 aa overlap). Conserved hypothetical protein, similar to Q49952 cosmid B1756 from Mycobacterium leprae (187 aa), FASTA scores: opt: 865, E(): 0, (72.4% identity in 174 aa overlap), also similar to FAS6_RHOFA|P46378 hypothetical 21.1 kd protein in fasciation locus (ORF6) (198 aa), FASTA scores: opt: 368,E(): 1.3e-17, (37.4% identity in 174 aa overlap). Some similarity to YJL055W Hypothetical protein in BTN1-PEP8 intergenic region from Saccharomyces cerevisiae and P48636 HYPOTHETICAL protein in AZU 5'REGION from Pseudomonas AERUGINOSA. Q7U0E3 No conserved hypotheticals Rv1205 NC_002945.3 Mycobrowser_v2 CDS 1350579 1352372 . + 0 Mb1238 fadD6 PROBABLE FATTY-ACID-COA LIGASE FADD6 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb1238, fadD6, len: 597 aa. Equivalent to Rv1206,len: 597 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 597 aa overlap). Probable fadD6,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0,(36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U0E2 No NC_002945.3 Mycobrowser_v2 CDS 1352438 1353394 . + 0 Mb1239 folP2 dihydropteroate synthase 2 folp2 (dhps 2) (dihydropteroate pyrophosphorylase 2) Mb1239, folP2, len: 318 aa. Equivalent to Rv1207,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 318 aa overlap). Probable folP2,Dihydropteroate synthase 2 (EC 2.5.1.15), similar to many e.g. DHPS_ECOLI|P26282 Escherichia coli (282 aa), FASTA scores: opt: 480, E(): 1.9e-22, (34.4% identity in 270 aa overlap). Contains PS00792 dihydropteroate synthase signature 1, PS00793 dihydropteroate synthase signature 2. X2BHD4,P64140 No NC_002945.3 Mycobrowser_v2 CDS 1353391 1354365 . + 0 Mb1240 gpgs probable glucosyl-3-phosphoglycerate synthase gpgs Mb1240, -, len: 324 aa. Equivalent to Rv1208, len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 324 aa overlap). Conserved hypothetical protein, similar to Q49955|U1756L Mycobacterium leprae (318 aa), FASTA scores, opt: 1621, E(): 0, (80.5% identity in 318 aa overlap). X2BGZ8,Q7U0E1 No intermediary metabolism and respiration Rv1208 NC_002945.3 Mycobrowser_v2 CDS 1354769 1355383 . + 0 Mb1242 tagA probable dna-3-methyladenine glycosylase i taga (tag i) (3-methyladenine-dna glycosylase i, constitutive) (dna-3-methyladenine glycosidase i) Mb1242, tagA, len: 204 aa. Equivalent to Rv1210,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 204 aa overlap). Probable tagA,DNA-3-methyladenine glycosidase I (EC 3.2.2.20), similar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichia coli (187 aa), FASTA scores: opt: 530, E(): 1.3e-27, (44.2% identity in 190 aa overlap). Also similar to Q49957 Mycobacterium leprae cosmid B1756 (192 aa), FASTA scores: opt: 1042, E(): 0,(80.2% identity in 192 aa overlap). Q7U0D9 No information pathways Rv1210 NC_002945.3 Mycobrowser_v2 CDS 1355745 1356908 . - 0 Mb1244c glga putative glycosyl transferase glga Mb1244c, -, len: 387 aa. Equivalent to Rv1212c,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Putative glycosyl transferase (EC 2.-.-.-), highly similar to AJ243803|SCO243803_2 Putative glycosyl transferase from Streptomyces coelicolor (387 aa), FASTA scores: opt: 1344,E(): 0, (54.9% identity in 388 aa overlap). Also similar to MJ1607 probable hexosyltransferase (EC 2.4.1.-) from Methanococcus jannaschii (390 aa), FASTA scores: opt: 445,E(): 7.8e-23, (27.9% identity in 401 aa overlap). The region from aa 267-355 highly similar to Q49959 COSMID B1756 from Mycobacterium leprae (91 aa), FASTA scores,opt: 471, E(): 4.8e-25, (80.9% identity in 89 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein, Rv3032. Q7U0D7 No intermediary metabolism and respiration Rv1212c NC_002945.3 Mycobrowser_v2 CDS 1357083 1358297 . + 0 Mb1245 glgC glucose-1-phosphate adenylyltransferase glgc (adp-glucose synthase) (adp-glucose pyrophosphorylase) Mb1245, glgC, len: 404 aa. Equivalent to Rv1213,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 404 aa overlap). Probable glgC,glucose-1-phosphate adenylyltransferase (EC 2.7.7.27),similar to many e.g. GLGC_ECOLI|P00584 Escherichia coli (430 aa), FASTA scores: opt: 1075, E(): 0, (40.3% identity in 407 aa overlap); highly similar to Q49961 GLGC from Mycobacterium leprae (419 aa), FASTA scores: opt: 2532,E(): 0, (92.6% identity in 404 aa overlap). BELONGS TO THE BACTERIAL AND PLANTS GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE FAMILY. X2BH06,P64242 No intermediary metabolism and respiration Rv1213 NC_002945.3 Mycobrowser_v2 CDS 1358493 1358867 . - 0 Mb1246c PE14 pe family protein pe14 Mb1246c, PE14, len: 124 aa. Equivalent to 5' end of Rv1214c, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 68 aa overlap). Member of Mycobacterium tuberculosis PE family, appears to be frameshifted but sequence appears to be correct. The 5'-end is atypical as first 9 aa appear to be missing. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus. Q7U0D6 No NC_002945.3 Mycobrowser_v2 CDS 1359001 1360686 . - 0 Mb1247c conserved protein Mb1247c, -, len: 561 aa. Equivalent to Rv1215c,len: 561 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 561 aa overlap). Conserved hypothetical protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kd protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). Q7U0D5 No conserved hypotheticals Rv1215c NC_002945.3 Mycobrowser_v2 CDS 1360714 1361388 . - 0 Mb1248c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb1248c, -, len: 224 aa. Equivalent to Rv1216c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 224 aa overlap). Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). Q7U0D4 No cell wall and cell processes Rv1216c NC_002945.3 Mycobrowser_v2 CDS 1369135 1369965 . - 0 Mb1257c CONSERVED HYPOTHETICAL PROTEIN Mb1257c, -, len: 276 aa. Equivalent to Rv1225c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 276 aa overlap). Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. AE001078|AE001078_2 Archaeoglobus fulgidus (265 aa),FASTA scores: opt: 339, E(): 5.1e-15, (27.1% identity in 262 aa overlap), and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa), FASTA scores: opt: 167,E(): 6.4e-12, (24.8% identity in 258 aa overlap). Also weakly similar to Mycobacterium tuberculosis hypothetical protein Rv3400|MTCY78.28c (29.1% identity in 251 aa overlap). Q7U0C6 No conserved hypotheticals Rv1225c NC_002945.3 Mycobrowser_v2 CDS 1361397 1363043 . - 0 Mb1249c PROBABLE TETRONASIN-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER Mb1249c, -, len: 548 aa. Equivalent to Rv1217c,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Probable tetronasin-transport integral membrane ABC transporter (see citation below), similar to many e.g. AL049754|SCH10_12 probable ABC-type transport system membrane-spanning protein from Streptomyces coelicolor (539 aa), FASTA scores: opt: 1309, E(): 0, (40.9% identity in 550 aa overlap); Q54407|X73633 TnrB3 protein from Streptomyces longisporoflavus (337 aa), FASTA scores: opt: 692, E(): 0, (39.5% identity in 324 aa overlap); etc. Also has regions similar to Mycobacterium leprae proteins Q49964|U1756Q (109 aa), FASTA scores: opt: 431, E(): 3.1e-20, (64.8% identity in 105 aa overlap) and Q49965|U1756R (82 aa), FASTA scores: opt:154, E(): 0.0028,(61.0% identity in 41 aa overlap). Q7U0D3 No cell wall and cell processes Rv1217c NC_002945.3 Mycobrowser_v2 CDS 1363040 1363975 . - 0 Mb1250c PROBABLE TETRONASIN-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER Mb1250c, -, len: 311 aa. Equivalent to Rv1218c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 311 aa overlap). Probable tetronasin-transport ATP-binding protein ABC transporter (see citation below), similar to many e.g. Q54406|X73633|TNRB2 TNRB2 PROTEIN from Streptomyces longisporoflavus (300 aa), FASTA scores: opt: 1133, E(): 0, (60.8% identity in 291 aa overlap); etc. Also similar to others in Mycobacterium tuberculosis e.g. MTCY19H9.04 (30.0% identity in 297 aa overlap); etc. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS) Q7U0D2 No cell wall and cell processes Rv1218c NC_002945.3 Mycobrowser_v2 CDS 1363965 1364603 . - 0 Mb1251c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1251c, -, len: 212 aa. Equivalent to Rv1219c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 212 aa overlap). Probable transcriptional regulatory protein, some similarity in N-terminus to YBIH_ECOLI|P41037 hypothetical transcriptional regulator from Escherichia coli (103 aa),FASTA scores: opt: 143, E(): 8.9e-06, (39.7% identity in 63 aa overlap); Helix turn helix motif from aa 28-49. Q7U0D1 No regulatory proteins Rv1219c NC_002945.3 Mycobrowser_v2 CDS 1364745 1365392 . - 0 Mb1252c PROBABLE METHYLTRANSFERASE Mb1252c, -, len: 215 aa. Equivalent to Rv1220c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Possible methyltransferase (EC 2.1.1.-), some similarity to MDMC_STRMY|Q00719 o-methyltransferase from Streptomyces mycarofaciens (221 aa), FASTA scores; opt: 289, E(): 1.3e-07, (30.0% identity in 203 aa overlap). Also similar to Mycobacterium tuberculosis methyltransferases Rv0187|MTCI28.26 (32.9% identity in 222 aa overlap) and Rv1703c. Start site chosen by homology; other possible start sites exist upstream. X2BH72,Q7U0D0 No intermediary metabolism and respiration Rv1220c NC_002945.3 Mycobrowser_v2 CDS 1365655 1366428 . + 0 Mb1253 sigE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGE Mb1253, sigE, len: 257 aa. Equivalent to Rv1221,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). sigE, alternative sigma factor of extracytoplasmic function (ECF) family (see citations below). Similar to many e.g. RPOE_HAEIN|P44790 RNA polymerase sigma-e factor from Haemophilus influenzae (189 aa), FASTA scores: opt: 247, E(): 3.4e-06, (28.5% identity in 186 aa overlap); etc. Also similar to MTCY07D11.03 rpoE from Mycobacterium tuberculosis (35.2% identity in 159 aa overlap). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Note that in Mycobacterium bovis BCG, the sigE gene is transcribed from two promoters, P1 and P2, and that these promoters were expressed at temperatures from 30-50 C. Q7U0C9 No information pathways Rv1221 NC_002945.3 Mycobrowser_v2 CDS 1366586 1367050 . + 0 Mb1254 rsea anti-sigma factor rsea Mb1254, -, len: 154 aa. Equivalent to Rv1222, len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Conserved hypothetical protein. Identical to O06290|MTU87242 (but shorter due to different start site chosen by proximity of RBS). Equivalent to O05736|U87308|MAU87308_2 hypothetical protein from Mycobacterium avium (133 aa), FASTA scores: opt: 644, E(): 7e-32, (86.2% identity in 109 aa overlap). Q7U0C8 No information pathways Rv1222 NC_002945.3 Mycobrowser_v2 CDS 1367119 1368705 . + 0 Mb1255 htrA PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN) Mb1255, htrA, len: 528 aa. Equivalent to Rv1223,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 528 aa overlap). Probable htrA (alternate gene name: degP), serine protease precursor (EC 3.4.21.-), equivalent to U15180|MLU15180_31|Q49972|ML1078|HTRA POSSIBLE SERINE PROTEASE from Mycobacterium leprae (533 aa), FASTA scores: opt: 2777, E(): 4.1e-141, (81.6% identity in 533 aa overlap). Also similar to many others e.g. HTRA_ECOLI|P09376 protease do precursor from Escherichia coli (EC 3.4.21.-) (474 aa), FASTA scores: opt: 581, E(): 9.1e-27, (36.3% identity in 278 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Start changed since first submission (-21 aa). Q7U0C7 No intermediary metabolism and respiration Rv1223 NC_002945.3 Mycobrowser_v2 CDS 1373021 1374193 . - 0 Mb1261c mrp PROBABLE MRP-RELATED PROTEIN MRP Mb1261c, mrp, len: 390 aa. Equivalent to Rv1229c,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 390 aa overlap). Probable Mrp protein,similar to others e.g. MRP_ECOLI|P21590 mrp protein from Escherichia coli (379 aa), FASTA scores: E(): 0, (34.1% identity in 355 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS01215 MRP Prosite domain. BELONGS TO THE MRP/NBP35 FAMILY OF ATP-BINDING PROTEINS. X2BHF8,P65442 No NC_002945.3 Mycobrowser_v2 CDS 2489863 2490324 . - 0 Mb2262c ahpE probable peroxiredoxin ahpe Mb2262c, ahpE, len: 153 aa. Equivalent to Rv2238c,len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). ahpE, peroxiredoxin. Similarity to many members of AHPC/TSA family e.g. sp|Q96291|BAS1_ARATH 2-CYS PEROXIREDOXIN BAS1 PRECURSOR (265 aa). FASTA score: opt: 275, E(): 2.7e-12; 35.0% identity in 143 aa overlap X2BK87,P65689 No NC_002945.3 Mycobrowser_v2 CDS 1374206 1375441 . - 0 Mb1262c POSSIBLE MEMBRANE PROTEIN Mb1262c, -, len: 411 aa. Equivalent to Rv1230c,len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 411 aa overlap). Possible membrane protein with two hydrophobic stretches near N-terminus. Some similarity to Rv1022|MTCY10G2.27c|Z92539 probable lpqU protein from Mycobacterium tuberculosis (243 aa),FASTA score: opt: 408, E(): 1e-11, (43.6% identity in 172 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa), FASTA score: opt: 679, E(): 5.1e-23, (36.4% identity in 398 aa overlap). Q7U0C2 No cell wall and cell processes Rv1230c NC_002945.3 Mycobrowser_v2 CDS 1375566 1376108 . - 0 Mb1263c PROBABLE MEMBRANE PROTEIN Mb1263c, -, len: 180 aa. Equivalent to Rv1231c,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 180 aa overlap). Probable membrane protein, similar to others e.g. AL390975 Streptomyces coelicolor (198 aa). Q7U0C1 No cell wall and cell processes Rv1231c NC_002945.3 Mycobrowser_v2 CDS 1376105 1377412 . - 0 Mb1264c conserved protein Mb1264c, -, len: 435 aa. Equivalent to Rv1232c,len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 435 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AB013374|AB013374_2 Bacillus halodurans C-125 mamX (449 aa), FASTA scores: opt: 381, E(): 1e-16, (29.9% identity in 251 aa overlap). Some similarity in N-terminus to U15180|MLU1518033 hypothetical Mycobacterium leprae protein u1756u (329 aa), FASTA scores: opt: 300, E(): 4.1e-12, (69.3% identity in 75 aa overlap). Q7U0C0 No conserved hypotheticals Rv1232c NC_002945.3 Mycobrowser_v2 CDS 1377474 1378070 . - 0 Mb1265c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1265c, -, len: 198 aa. Equivalent to Rv1233c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 198 aa overlap). Conserved hypothetical membrane protein, N-terminus is highly proline rich,C-terminus has two hydrophobic stretches. Proline-rich N-terminus has some similarity to CBPA_DICDI calcium binding protein from Dictyostelium discoideum (467 aa),FASTA scores: E(): 4.8e-06, (35.5% identity in 183 aa overlap). Both sequences share multiple copies of a Tyr-Pro-Pro motif. Q7U0B9 No cell wall and cell processes Rv1233c NC_002945.3 Mycobrowser_v2 CDS 1378768 1380174 . + 0 Mb1267 lpqY PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY Mb1267, lpqY, len: 468 aa. Equivalent to Rv1235,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 468 aa overlap). Probable lpqY,sugar-binding lipoprotein component of sugar transport system (see citation below), equivalent to MLU1518034 protein u1756v from Mycobacterium leprae (469 aa), FASTA scores: opt: 2442, E(): 0, (77.4% identity in 470 aa overlap). Also similar to P18815|MALE_ENTAE MALTOSE-BINDING PERIPLASMIC PROTEIN from Enterobacter aerogenes (396 aa), FASTA scores: opt: 193, E(): 2.3e-05,(24.2% identity in 297 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. I3NIF6 No cell wall and cell processes Rv1235 NC_002945.3 Mycobrowser_v2 CDS 1380171 1381094 . + 0 Mb1268 sugA PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA Mb1268, sugA, len: 307 aa. Equivalent to Rv1236,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Probable sugA,sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to U15180|MLU1518035 protein malFM from Mycobacterium leprae (310 aa), FASTA scores: opt: 1566, E(): 0, (81.8% identity in 292 aa overlap). Also similar to numerous bacterial sugar transport system components. Also similar to Rv2316|MTCY3G12.18c from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 514, E(): 7.3e-27, (33.2% identity in 283 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Q7U0B7 No cell wall and cell processes Rv1236 NC_002945.3 Mycobrowser_v2 CDS 1381099 1381923 . + 0 Mb1269 sugB PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB Mb1269, sugB, len: 274 aa. Equivalent to Rv1237,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Probable sugB,sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to U15180|MLU1518036 protein MalGM from Mycobacterium leprae (296 aa), FASTA scores: opt: 1571, E(): 0, (89.8% identity in 274 aa overlap). Also similar to numerous bacterial sugar transport protein. Related to Rv2834c|MTCY16B7.08 from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 370, E(): 2.4e-17, (26.8% identity in 269 aa overlap). Q7U0B6 No cell wall and cell processes Rv1237 NC_002945.3 Mycobrowser_v2 CDS 1381928 1383109 . + 0 Mb1270 sugC PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC Mb1270, sugC, len: 393 aa. Equivalent to Rv1238,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Probable sugC,sugar-transport ATP-binding protein ABC transporter (see citation below). Highly similar to U15180 protein ugpC from Mycobacterium leprae (392 aa), FASTA score: opt: 2007, E(): 0, (79.9% identity in 389 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7U0B5 No cell wall and cell processes Rv1238 NC_002945.3 Mycobrowser_v2 CDS 1383186 1384286 . - 0 Mb1271c corA POSSIBLE MAGNESIUM AND COBALT TRANSPORT TRANSMEMBRANE PROTEIN CORA Mb1271c, corA, len: 366 aa. Equivalent to Rv1239c,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 366 aa overlap). Possible corA,magnesium and cobalt transport transmembrane protein,highly similar to U15180 corA protein from Mycobacterium leprae (373 aa), FASTA scores: opt: 1985, E(): 0, (79.1% identity in 369 aa overlap). Also similar to various CorA proteins of Gram negative bacteria e.g. P27841|CORA_ECOLI|B3816|Z5333|ECS4746 Magnesium and cobalt transport protein from Escherichia coli strains K12 and O157:H7 (316 aa), FASTA scores: opt: 236, E(): 8e-08,(24.5% identity in 306 aa overlap); etc. SEEMS TO BELONG TO THE MIT FAMILY. Q7U0B4 No NC_002945.3 Mycobrowser_v2 CDS 1384457 1385446 . + 0 Mb1272 mdh PROBABLE MALATE DEHYDROGENASE MDH Mb1272, mdh, len: 329 aa. Equivalent to Rv1240,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 329 aa overlap). Probable mdh, Malate dehydrogenase (EC 1.1.1.37). Most similar to P50917|MDH_MYCLE MALATE DEHYDROGENASE from Mycobacterium leprae (329 aa), FASTA scores: opt: 1887, E(): 0, (89.1% identity in 329 aa overlap). Contains PS00068 Malate dehydrogenase active site signature. BELONGS TO THE LDH FAMILY. MDH SUBFAMILY. X2BH84,P0A5J7 No intermediary metabolism and respiration Rv1240 NC_002945.3 Mycobrowser_v2 CDS 1385522 1385782 . + 0 Mb1273 vapb33 possible antitoxin vapb33 Mb1273, -, len: 86 aa. Equivalent to Rv1241, len: 86 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 86 aa overlap). Conserved hypothetical protein, member of family of 16 hypothetical M. tuberculosis proteins including: Rv2871|Q10799|YS71_MYCTU HYPOTHETICAL 13.2 KD PROTEIN CY2 (124 aa), FASTA scores: opt: 172, E(): 9.5e-06, (37.2% identity in 86 aa overlap); Rv2132, Rv3321c, etc. Q7U0B3 No virulence, detoxification, adaptation Rv1241 NC_002945.3 Mycobrowser_v2 CDS 1385779 1386210 . + 0 Mb1274 vapc33 possible toxin vapc33. contains pin domain. Mb1274, -, len: 143 aa. Equivalent to Rv1242, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 143 aa overlap). Conserved hypothetical protein, member of family of 14 hypothetical M. tuberculosis proteins including: Rv2872|Q10800|YS72_MYCTU (147 aa), FASTA scores: opt: 226, E(): 2.7e-09, (32.1% identity in 137 aa overlap); Rv0749, Rv0277c, Rv2530c,etc. Q7U0B2 No virulence, detoxification, adaptation Rv1242 NC_002945.3 Mycobrowser_v2 CDS 1386233 1387921 . - 0 Mb1275c PE_PGRS23 pe-pgrs family protein pe_pgrs23 Mb1275c, PE_PGRS23, len: 562 aa. Equivalent to Rv1243c, len: 562 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 562 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Q7U0B1 No NC_002945.3 Mycobrowser_v2 CDS 1390601 1394296 . - 0 Mb1280c sucA Multifunctional alpha-ketoglutarate metabolic enzyme Mb1280c, len: 1231 aa. Equivalent to Rv1248c len: 1231 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 1231 aa overlap). Multifunctional alpha-ketoglutarate metabolic enzyme, highly similar to D84102 Corynebacterium glutamicum (1257 aa), FASTA scores: opt: 4418, E(): 0, (59.4% identity in 1223 aa overlap). Cofactor: thiamine diphosphate. Start changed since first submission (+17 aa). X2BH56,Q7U0A6 No intermediary metabolism and respiration Rv1248c NC_002945.3 Mycobrowser_v2 CDS 1388101 1388961 . + 0 Mb1276 lpqZ probable lipoprotein lpqz Mb1276, lpqZ, len: 286 aa. Equivalent to Rv1244,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Probable lipoprotein lpqZ, equivalent to U15180|MLU1518042 protein u1756x from Mycobacterium leprae (228 aa), FASTA scores: opt: 1039,E(): 0, (72.5% identity in 229 aa overlap). Similar to M. tuberculosis hypothetical protein Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U0B0 No cell wall and cell processes Rv1244 NC_002945.3 Mycobrowser_v2 CDS 1446077 1447420 . + 0 Mb1325 lysA diaminopimelate decarboxylase lysa (dap decarboxylase) Mb1325, lysA, len: 447 aa. Equivalent to Rv1293,len: 447 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 447 aa overlap). Probable lysA,diaminopimelate decarboxylase (EC 4.1.1.20) (see citation below), almost identical to DCDA_MYCTU|P31848. Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site, PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. BELONGS TO FAMILY 2 OF ORNITHINE, DAP, AND ARGININE DECARBOXYLASES. X2BHB0,P0A5M5 No intermediary metabolism and respiration Rv1293 NC_002945.3 Mycobrowser_v2 CDS 1389042 1389872 . - 0 Mb1277c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb1277c, -, len: 276 aa. Equivalent to Rv1245c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 276 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to NP_301801.1|NC_002677 short chain alcohol dehydrogenase from Mycobacterium leprae (277 aa). Also highly similar to various dehydrogenases and oxidoreductases e.g. NP_250228.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (295 aa); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3085|MTV013.06 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (276 aa), FASTA scores: opt: 368,E(): 1.2e-16, (35.3% identity in 224 aa overlap); Rv3057c|MTCY22D7.24 PUTATIVE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE (287 aa), FASTA scores: opt: 471,E(): 1.3e-21, (32.4% identity in 281 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U0A9 No intermediary metabolism and respiration Rv1245c NC_002945.3 Mycobrowser_v2 CDS 1389929 1390222 . - 0 Mb1278c rele toxin rele Mb1278c, -, len: 97 aa. Equivalent to Rv1246c, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 97 aa overlap). Conserved hypothetical protein, highly similar to Rv2866|MTV003.12 hypothetical Mycobacterium tuberculosis protein (87 aa), FASTA scores: opt: 290, E(): 3.9e-24, (54.1% identity in 85 aa overlap). Q7U0A8 No virulence, detoxification, adaptation Rv1246c NC_002945.3 Mycobrowser_v2 CDS 1390219 1390488 . - 0 Mb1279c relb antitoxin relb Mb1279c, -, len: 89 aa. Equivalent to Rv1247c, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 89 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins including Mycobacterium tuberculosis proteins Rv2865|MTV003.11 (93 aa), FASTA scores: opt: 249, E(): 5.4e-13, (44.2% identity in 86 aa overlap); Rv0268|Z86089|P95225 (169 aa) opt: 125, E(): 0.0089,(41.8% identity in 55 aa overlap); etc. and AE000293|ECAE0002933 from Escherichia coli (92 aa), FASTA scores: opt: 127, E(): 0.0038, (29.3% identity in 82 aa overlap). Q7U0A7 No virulence, detoxification, adaptation Rv1247c NC_002945.3 Mycobrowser_v2 CDS 1394438 1395226 . - 0 Mb1281c POSSIBLE MEMBRANE PROTEIN Mb1281c, -, len: 262 aa. Equivalent to Rv1249c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 262 aa overlap). Possible membrane protein. Start uncertain. Q7U0A5 No cell wall and cell processes Rv1249c NC_002945.3 Mycobrowser_v2 CDS 1395423 1397162 . + 0 Mb1282 PROBABLE DRUG-TRANSPORT INTEGRAL MEMBRANE PROTEIN Mb1282, -, len: 579 aa. Equivalent to Rv1250, len: 579 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 579 aa overlap). Probable drug-transport integral membrane protein, member of major facilitator superfamily (MFS), highly similar to several including P39886|TCMA_STRGA TETRACENOMYCIN C RESISTANCE PROTEIN from Streptomyces glaucescens (538 aa), FASTA scores: opt: 847, E(): 0, (32.9% identity in 517 aa overlap); etc. Also similar to MTCY20B11.14c|Rv3239C from Mycobacterium tuberculosis (1048 aa), FASTA scores: opt: 629, E(): 6.7e-13, (31.9% identity in 423 aa overlap). TBparse score is 0.921. Q7U0A4 No cell wall and cell processes Rv1250 NC_002945.3 Mycobrowser_v2 CDS 1397065 1400484 . - 0 Mb1283c CONSERVED HYPOTHETICAL PROTEIN Mb1283c, -, len: 1139 aa. Equivalent to Rv1251c,len: 1139 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1139 aa overlap). Conserved hypothetical protein, showing some similarity in C-terminal region with other proteins from eukaryotes and bacteria e.g. NP_142121.1 hypothetical protein from Pyrococcus horikoshii (1188 aa); and some similarity to GTP-binding proteins e.g. P23249|MV10_MOUSE PUTATIVE GTP-BINDING PROTEIN (1004 aa), FASTA scores: opt: 228,E(): 1.7e-06, (27.7% identity in 560 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U0A3 No conserved hypotheticals Rv1251c NC_002945.3 Mycobrowser_v2 CDS 1400540 1401148 . - 0 Mb1284c lprE PROBABLE LIPOPROTEIN LPRE Mb1284c, lprE, len: 202 aa. Equivalent to Rv1252c,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 202 aa overlap). Probable lipoprotein lprE, some similarity to Mycobacterium tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA scores: E(): 7e-05, (29.5% identity in 200 aa overlap). Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). X2BHG1,P65313 No NC_002945.3 Mycobrowser_v2 CDS 1401214 1402905 . + 0 Mb1285 deaD PROBABLE COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG DEAD (ATP-dependent RNA helicase deaD homolog) Mb1285, deaD, len: 563 aa. Equivalent to Rv1253,len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 563 aa overlap). Probable Dead,Cold-shock DEAD-box protein A homolog, similar to many e.g. DEAD_ECOLI|P23304 Escherichia coli (646 aa), FASTA scores: opt: 1490, E(): 0, (46.7% identity in 578 aa overlap); similar to Mycobacterium tuberculosis Rv3211. Contains PS00017 ATP/GTP-binding site motif A, PS00039 DEAD-box subfamily ATP-dependent helicases signature. BELONGS TO THE DEAD BOX FAMILY HELICASE. Q7U0A2 No information pathways Rv1253 NC_002945.3 Mycobrowser_v2 CDS 1402902 1404053 . + 0 Mb1286 PROBABLE ACYLTRANSFERASE Mb1286, -, len: 383 aa. Equivalent to Rv1254, len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 383 aa overlap). Probable Acyltransferase (EC 2.3.1.-), similar to G927228 midecamycin 4-0-propionyl transferase (fragment) (388 aa),FASTA scores, opt: 305, E(): 5.6e-14, (28.4% identity in 377 aa overlap). Also similar to other Mycobacterium tuberculosis acyltransferases e.g. Rv0111, Rv0228, etc. Contains PS00881 Protein splicing signature. Q7U0A1 No intermediary metabolism and respiration Rv1254 NC_002945.3 Mycobrowser_v2 CDS 1418556 1420451 . - 0 Mb1303c PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER Mb1303c, -, len: 631 aa. Equivalent to Rv1272c,len: 631 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 631 aa overlap). Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. Y015_MYCGE|P47261 hypothetical ABC transporter mg015m from Mycoplasma genitalium (589 aa), FASTA scores: opt: 1054,E(): 0, (34.3% identity in 522 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS),MSBA SUBFAMILY. X2BHV5,P63398 No cell wall and cell processes Rv1272c NC_002945.3 Mycobrowser_v2 CDS 1404022 1404321 . - 0 Mb1287c probable transcriptional regulatory protein Mb1287c, -, len: 99 aa. Equivalent to 5' end of Rv1257c and 3' end of Rv1255c, len: 455 aa and 202 aa,from Mycobacterium tuberculosis strain H37Rv, (89.5% identity in 57 aa overlap and 83.6% identity in 67 aa overlap). Rv1257c: Probable oxidoreductase (EC 1.-.-.-),similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. Rv1255c: Possible regulatory protein, similar to others e.g. ACRR_ECOLI|P34000 potential acrab operon repressor from E. coli (215 aa), FASTA scores: opt: 128, E(): 0.25, (42.1% identity in 57 aa overlap). Helix turn helix motif present at aa 36-57 (+5.48 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv. Q7U0A0 No NC_002945.3 Mycobrowser_v2 CDS 1404318 1405577 . - 0 Mb1288c PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Mb1288c, -, len: 419 aa. Equivalent to Rv1258c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 419 aa overlap). Probable conserved integral membrane transport (efflux) protein, possibly member of major facilitator superfamily (MFS), highly similar to O32859|TAP PROTEIN multidrug-resistance efflux pump from Mycobacterium fortuitum (409 aa), FASTA scores: E(): 0, (68.4% identity in 408 aa overlap). Contains PS00216 Sugar transport proteins signature 1. X2BHU3,P64784 No cell wall and cell processes Rv1258c NC_002945.3 Mycobrowser_v2 CDS 2193218 2193730 . + 0 Mb1990 higb possible toxin higb Mb1990, -, len: 170 aa. Equivalent to Rv1955, len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 170 aa overlap). Hypothetical unknown protein, start overlaps another ORF, Rv1954c (MTCY09F9.10). Q7TZ77 No virulence, detoxification, adaptation Rv1955 NC_002945.3 Mycobrowser_v2 CDS 1406477 1407301 . + 0 Mb1290 PROBABLE OXIDOREDUCTASE [FIRST PART] Mb1290, -, len: 274 aa. Equivalent to 5' end of Rv1260, len: 372 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 260 aa overlap). Probable oxidoreductase (EC 1.-.-.-), highly similar to E1245747|AL021411 putative oxidoreductase SC7H1.18 from Streptomyces coelicolor (397 aa), FASTA scores: E(): 1.4e-29, (45.9% identity in 355 aa overlap); also some similarity to G912582 FAD binding protein homologue from Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245,E(): 2e-09, (27.5% identity in 251 aa overlap); PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity in 360 aa overlap); TETX_BACFR|Q01911 tetracycline resistance protein (388 aa), FASTA scores: opt: 183, E(): 3e-05, (22.8% identity in 373 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0575c and Rv1751. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts,Mb1290 and Mb1291. Q7U099 No NC_002945.3 Mycobrowser_v2 CDS 1411496 1412176 . + 0 Mb1296 unknown protein Mb1296, -, len: 226 aa. Equivalent to Rv1265, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 226 aa overlap). Hypothetical unknown protein (see citation below). X2BHK3 No conserved hypotheticals Rv1265 NC_002945.3 Mycobrowser_v2 CDS 1502391 1503113 . + 0 Mb1372 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb1372, -, len: 240 aa. Equivalent to Rv1337, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 240 aa overlap). Probable integral membrane protein. Highly similar to P53426 hypothetical protein B1549_C3_240 from M.leprae (251); and P74553|D90916 hypothetical protein from Synechocystis sp. (198 aa), FASTA scores: E(): 2.3e-25, (43.6% identity in 181 aa overlap). X2BHL6,P64816 No cell wall and cell processes Rv1337 NC_002945.3 Mycobrowser_v2 CDS 1407286 1407594 . + 0 Mb1291 PROBABLE OXIDOREDUCTASE [SECOND PART] Mb1291, -, len: 102 aa. Equivalent to 3' end of Rv1260, len: 372 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 102 aa overlap). Probable oxidoreductase (EC 1.-.-.-), highly similar to E1245747|AL021411 putative oxidoreductase SC7H1.18 from Streptomyces coelicolor (397 aa), FASTA scores: E(): 1.4e-29, (45.9% identity in 355 aa overlap); also some similarity to G912582 FAD binding protein homologue from Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245,E(): 2e-09, (27.5% identity in 251 aa overlap); PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity in 360 aa overlap); TETX_BACFR|Q01911 tetracycline resistance protein (388 aa), FASTA scores: opt: 183, E(): 3e-05, (22.8% identity in 373 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0575c and Rv1751. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts,Mb1290 and Mb1291. Q7U098 No NC_002945.3 Mycobrowser_v2 CDS 1407720 1408169 . - 0 Mb1292c conserved protein Mb1292c, -, len: 149 aa. Equivalent to Rv1261c,len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 149 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1558|MTCY48.07c (39.2% identity in 125 aa overlap); Rv3547 and Rv3178. X2BH95,P64788 No conserved hypotheticals Rv1261c NC_002945.3 Mycobrowser_v2 CDS 1408174 1408608 . - 0 Mb1293c HYPOTHETICAL HIT-LIKE PROTEIN Mb1293c, -, len: 144 aa. Equivalent to Rv1262c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 144 aa overlap). Hypothetical HIT-like protein, similar to Q04344|HIT_YEAST hit1 protein (orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9 % identity in 142 aa overlap); also similar to YHIT_MYCGE|P47378 hypothetical 15.6 kd protein (141 aa),FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity in 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical 17.0 kd protein hit-like (155 aa), FASTA scores: opt: 196, E(): 7e-07, (30.6% identity in 144 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. Rv2613c, Rv0759c. Contains PS00892 HIT family signature. BELONGS TO THE HIT FAMILY. Q7U097 No conserved hypotheticals Rv1262c NC_002945.3 Mycobrowser_v2 CDS 1408667 1410055 . + 0 Mb1294 amiB2 PROBABLE AMIDASE AMIB2 (AMINOHYDROLASE) Mb1294, amiB2, len: 462 aa. Equivalent to Rv1263,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 462 aa overlap). Probable amiB2, amidase (EC 3.5.1.4). Similar to G1001278 hypothetical 54.3 kDa protein (506 aa), FASTA scores: opt: 767, E(): 7.6e-40,(32.8% identity in 461 aa overlap), also similar to G580673 rhodococcus enantiose lective amidase gene (462 aa), FASTA scores, opt: 668, E(): 7.4e-34, (33.5% identity in 484 aa overlap); and to NYLA_PSES8|P13398 6-aminohexanoate-cyclic-dimer hydrolase (492 aa), FASTA scores opt: 543, E(): 3.1e-26, (33.5% identity in 493 aa overlap). Also similar to MTCY274.19c (33.5% identity in 427 aa overlap). Similar to other putative amidases in M. tuberculosis e.g. Rv2363, Rv2888c, etc. Contains PS00017 ATP/GTP-binding site motif A. BELONGS TO THE AMIDASE FAMILY. X2BHG8,P63493 No NC_002945.3 Mycobrowser_v2 CDS 1410130 1411323 . + 0 Mb1295 ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) Mb1295, -, len: 397 aa. Equivalent to Rv1264, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Adenylate cyclase (EC 4.6.1.1) (function proven experimentally: see first citation below), showing some similarity to other adenylate cyclases e.g. CYAA_BRELI|P27580 (403 aa), FASTA scores, opt: 270, E(): 1.3e-10, (29.3% identity in 317 aa overlap); etc. Similar to other putative cyclases in M. tuberculosis e.g. Rv2212, Rv1647. BELONG TO THE ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY. The C terminus seems to code for a catalytic domain belonging to a subfamily of adenylyl cyclase isozymes (mostly found in Gram-positive bacteria). The N terminus seems to be a potential novel regulator of adenylyl cyclase activity (autoinhibitory domain). Q7U096 No intermediary metabolism and respiration Rv1264 NC_002945.3 Mycobrowser_v2 CDS 1412196 1413986 . - 0 Mb1297c pknH PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKNH (PROTEIN KINASE H) (STPK H) Mb1297c, pknH, len: 596 aa. Similar to Rv1266c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(93.0% identity in 627 aa overlap). Probable pknH,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to many e.g. PKN1_MYXXA|P33973 pkn1 (693 aa), FASTA scores: opt: 611,E(): 1.4e- 14, (29.7% identity in 492 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature; PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa). X2BH99,Q7U095 No NC_002945.3 Mycobrowser_v2 CDS 1414327 1415493 . - 0 Mb1298c embR PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR Mb1298c, embR, len: 388 aa. Equivalent to Rv1267c,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 388 aa overlap). Probable embR,regulatory protein (see citation below), similar to many e.g. AFSR_STRCO|P25941 regulatory protein AfsR from Streptomyces coelicolor (993 aa), FASTA scores: opt: 489,E(): 1e-25, (33.5% identity in 361 aa overlap); etc. BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS. X2BHV0,P66800 No NC_002945.3 Mycobrowser_v2 CDS 1415804 1416502 . - 0 Mb1299c HYPOTHETICAL PROTEIN Mb1299c, -, len: 232 aa. Equivalent to Rv1268c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 232 aa overlap). Hypothetical unknown protein, probably secreted protein : contains possible signal peptide sequence (score 7.9 at residue 28). X2BHH1 No conserved hypotheticals Rv1268c NC_002945.3 Mycobrowser_v2 CDS 1416725 1417099 . - 0 Mb1300c CONSERVED PROBABLE SECRETED PROTEIN Mb1300c, -, len: 124 aa. Equivalent to Rv1269c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Conserved probable exported protein with putative N-terminal signal sequence. Similar to Mycobacterium tuberculosis protein Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30 (137 aa), FASTA scores: E(): 9e-21, (41.6% identity in 137 aa overlap). X2BH85 No cell wall and cell processes Rv1269c NC_002945.3 Mycobrowser_v2 CDS 1417160 1417894 . - 0 Mb1301c lprA possible lipoprotein lpra Mb1301c, lprA, len: 244 aa. Equivalent to Rv1270c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 244 aa overlap). Putative lipoprotein lprA (Precursor). Similar to O32852|AJ000500 lipoprotein from Mycobacterium bovis (236 aa), fasta scores: E(): 5.2e-23, (35.1% identity in 245 aa overlap). Similar to M. tuberculosis lipoproteins: Rv1368, Rv1411c, Rv2945c. Contains probable N-terminal signal sequence. X2BHL0,Q7U094 No NC_002945.3 Mycobrowser_v2 CDS 1418107 1418448 . - 0 Mb1302c CONSERVED HYPOTHETICAL SECRETED PROTEIN Mb1302c, -, len: 113 aa. Equivalent to Rv1271c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 113 aa overlap). Conserved hypothetical exported protein with potential N-terminal signal sequence. Similar to Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, Rv0622, etc. X2BHA4 No cell wall and cell processes Rv1271c NC_002945.3 Mycobrowser_v2 CDS 1420448 1422196 . - 0 Mb1304c PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER Mb1304c, -, len: 582 aa. Equivalent to Rv1273c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 582 aa overlap). Probable drug-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. YWJA_BACSU|P45861 hypothetical abc transporter from Bacillus subtilis (575 aa), FASTA scores: opt: 810, E(): 0, (27.0% identity in 578 aa overlap); etc. Contains PS00136 Serine proteases,subtilase family, aspartic acid active site; 2 x PS00211 ABC transporters family signature; and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS),MSBA SUBFAMILY. X2BHH5,P0A4W5 No cell wall and cell processes Rv1273c NC_002945.3 Mycobrowser_v2 CDS 1422343 1422900 . + 0 Mb1305 lprB possible lipoprotein lprb Mb1305, lprB, len: 185 aa. Equivalent to Rv1274,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 185 aa overlap). Possible lipoprotein lprB, contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013) . Some similarity to Rv1275. X2BH93,Q7U093 No cell wall and cell processes Rv1274 NC_002945.3 Mycobrowser_v2 CDS 1422897 1423439 . + 0 Mb1306 lprC possible lipoprotein lprc Mb1306, lprC, len: 180 aa. Equivalent to Rv1275,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 180 aa overlap). Possible lipoprotein lprC, contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Some similarity to Rv1274. Q7U092 No cell wall and cell processes Rv1275 NC_002945.3 Mycobrowser_v2 CDS 1423584 1424060 . - 0 Mb1307c CONSERVED HYPOTHETICAL PROTEIN Mb1307c, -, len: 158 aa. Equivalent to Rv1276c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 158 aa overlap). Conserved hypothetical protein, similar to AL096844|SCI28.03 hypothetical protein from Streptomyces coelicolor (172 aa), FASTA scores: opt: 385, E(): 3.3e-19, (43.5% identity in 161 aa overlap). Some similarity to P76502|SIXA_ECOLI PHOSPHOHISTIDINE PHOSPHATASE SIXA (161 aa), FASTA scores: opt: 146, E(): 0.0047, (31.9% identity in 116 aa overlap). BELONGS TO THE SIXA FAMILY OF PHOSPHATASES. Q7U091 No conserved hypotheticals Rv1276c NC_002945.3 Mycobrowser_v2 CDS 1424310 1425563 . + 0 Mb1308 CONSERVED HYPOTHETICAL PROTEIN Mb1308, -, len: 417 aa. Equivalent to Rv1277, len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 417 aa overlap). Conserved hypothetical protein, some similarity to 3914967|O68033|SBCD_RHOCA EXONUCLEASE SBCD HOMOLOG from Rhodobacter capsulatus (405 aa). May be sbcD protein (see first citation below) Q7U090 No conserved hypotheticals Rv1277 NC_002945.3 Mycobrowser_v2 CDS 1425560 1428187 . + 0 Mb1309 HYPOTHETICAL PROTEIN Mb1309, -, len: 875 aa. Equivalent to Rv1278, len: 875 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 875 aa overlap). Hypothetical unknown protein, possible coiled-coil regions, contains PS00017 ATP/GTP-binding site motif A. X2BHH7 No conserved hypotheticals Rv1278 NC_002945.3 Mycobrowser_v2 CDS 1428208 1429794 . + 0 Mb1310 PROBABLE DEHYDROGENASE FAD flavoprotein GMC oxidoreductase Mb1310, -, len: 528 aa. Equivalent to Rv1279, len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 528 aa overlap). Probable dehydrogenase,FAD flavoprotein GMC oxidoreductase (EC 1.1.-.-), similar to several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from Escherichia coli (556 aa), FASTA scores, opt: 1047,E(): 0, (37.7% identity in 541 aa overlap). Similar to Rv0697 putative Mycobacterium tuberculosis GMC oxidoreductase. Contains PS00623 GMC oxidoreductases signature 1, and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. X2BH98,P64264 No intermediary metabolism and respiration Rv1279 NC_002945.3 Mycobrowser_v2 CDS 1503110 1503925 . + 0 Mb1373 murI PROBABLE GLUTAMATE RACEMASE MURI Mb1373, murI, len: 271 aa. Equivalent to Rv1338,len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 271 aa overlap). Probable murI,glutamate racemase (EC 5.1.1.3), highly similar to many e.g. MURI_MYCLE|P46705 (272 aa), FASTA scores: opt: 1559,E(): 0, (88.9% identity in 271 aa overlap). Contains PS00924 Aspartate and glutamate racemases signature 2. X2BI28,P63636 No cell wall and cell processes Rv1338 NC_002945.3 Mycobrowser_v2 CDS 1429811 1431586 . - 0 Mb1311c oppA PROBABLE PERIPLASMIC OLIGOPEPTIDE-BINDING LIPOPROTEIN OPPA Mb1311c, oppA, len: 591 aa. Equivalent to Rv1280c,len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 591 aa overlap). Probable oppA,oligopeptide-binding lipoprotein component of peptide transport system (see citation below), sharing some similarity to other periplasmic solute binding proteins e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding protein from Salmonella typhimurium (542 aa), FASTA scores: E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also similar to Rv1166 and Rv2585c from Mycobacterium tuberculosis. Has possible N-terminal signal sequence and prokaryotic lipoprotein lipid attachment site (PS00013). BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 5. X2BHM1,P66772 No NC_002945.3 Mycobrowser_v2 CDS 1431579 1433417 . - 0 Mb1312c oppD PROBABLE OLIGOPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER OPPD Mb1312c, oppD, len: 612 aa. Equivalent to Rv1281c,len: 612 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 612 aa overlap). Probable oppD,oligopeptide-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. DPPD_BACSU|P26905 dipeptide transport ATP-binding protein from Bacillus subtilis (335 aa), FASTA scores: opt: 983,E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BHC0,P63396 No NC_002945.3 Mycobrowser_v2 CDS 1443107 1443421 . + 0 Mb1322 HYPOTHETICAL PROTEIN Mb1322, -, len: 104 aa. Equivalent to Rv1290A, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 104 aa overlap). Hypothetical unknown protein, equivalent to AAK45590 from Mycobacterium tuberculosis strain CDC1551 (122 aa) but shorter 18 aa. Q7U087 No conserved hypotheticals Rv1290A NC_002945.3 Mycobrowser_v2 CDS 1433414 1434289 . - 0 Mb1313c oppC PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER OPPC Mb1313c, oppC, len: 291 aa. Equivalent to Rv1282c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 291 aa overlap). Probable oppC,oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. OPPC_ECOLI|P77664 oligopeptide transport system permease from Escherichia coli (302 aa), FASTA scores: E(): 4.6e-33, (40.7% identity in 275 aa overlap); etc. Also similar to Rv3664c|DPPC probable peptide-transport integral membrane protein from Mycobacterium tuberculosis. X2BHW2,P66965 No NC_002945.3 Mycobrowser_v2 CDS 1434286 1435263 . - 0 Mb1314c oppB PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER OPPB Mb1314c, oppB, len: 325 aa. Equivalent to Rv1283c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 325 aa overlap). Probable oppB,oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide transport system permease protein from Escherichia coli (339 aa), FASTA scores: opt: 402, E(): 3.4e-20, (31.0% identity in 345 aa overlap); etc. Also similar to Rv3665c|DppB probable peptide-transport integral membrane protein from Mycobacterium tuberculosis. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. X2BHI0,P66967 No NC_002945.3 Mycobrowser_v2 CDS 1435470 1435961 . + 0 Mb1315 cana beta-carbonic anhydrase Mb1315, -, len: 163 aa. Equivalent to Rv1284, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 163 aa overlap). Conserved hypothetical protein, similar to AL109663|SC4A10.26 hypothetical protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 567, E(): 1.5e-32, (53.4% identity in 163 aa overla); shows some similarity to hypothetical protein from Methanobacterium thermoautotrophicum. Weak similarity to carbonic anhydrases e.g. U51624|MTU516242|P17582 Methanothermobacter thermautotrophicus (171 aa), FASTA score: opt: 305, E(): 1 .2e-14, (35.2% identity in 165 aa overlap). X2BHA3,P64798 No intermediary metabolism and respiration Rv1284 NC_002945.3 Mycobrowser_v2 CDS 1441531 1443096 . - 0 Mb1321c conserved protein Mb1321c, -, len: 521 aa. Equivalent to Rv1290c,len: 521 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 521 aa overlap). Conserved hypothetical protein, similar to AL031013|SC8A6.09 hypothetical protein from Streptomyces coelicolor (443 aa), FASTA scores: opt: 371, E(): 9.5e-17, (28.3% identity in 446 aa overlap). X2BHN2,P0A5E4 No conserved hypotheticals Rv1290c NC_002945.3 Mycobrowser_v2 CDS 1466924 1467541 . - 0 Mb1346c POSSIBLE TRANSPOSASE [FIRST PART] Mb1346c, -, len: 205 aa. Equivalent to 5' end of Rv1313c, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 195 aa overlap). Possible IS1557 transposase, similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase for insertion sequence element IS1001 from Bordetella parapertussis (406 aa), FASTA scores: opt: 254, E(): 3.3e-10, (24.9% identity in 402 aa overlap). Also similar to putative Mycobacterium tuberculosis transposases,Rv3798 and Rv0741. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts, Mb1345c and Mb1346c. Q7TTK1 No NC_002945.3 Mycobrowser_v2 CDS 1436055 1437053 . + 0 Mb1316 cysD PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2 CYSD Mb1316, cysD, len: 332 aa. Equivalent to Rv1285,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 332 aa overlap). Probable cysD, sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (see first citation below), homology suggests start site at aa 24 or 28, similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate transferase subunit 2 from Escherichia coli (302 aa),FASTA score: opt: 973, E():0, (52.5% identity in 303 aa overlap). Also similar to Mycobacterium tuberculosis Rv2392, 3'-phosphoadenylylsulfate reductase. BELONGS TO THE PAPS REDUCTASE FAMILY. CYSD SUBFAMILY. Thought to be differentially expressed within host cells (see third citation below). X2BHM7,P65671 No intermediary metabolism and respiration Rv1285 NC_002945.3 Mycobrowser_v2 tRNA 1510763 1510846 . + 0 leuW leuW tRNA-Leu leuW, len: 84 nt. Equivalent to leuW, len: 84 nt,from Mycobacterium tuberculosis strain H37RV, (100.0% identity in 84 nt overlap). tRNA-Leu, anticodon tag. No NC_002945.3 Mycobrowser_v2 CDS 1437053 1438897 . + 0 Mb1317 cysN PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC: SULFATE ADENYLTRANSFERASE (SUBUNIT 1) + ADENYLYLSULFATE KINASE Mb1317, cysN, len: 614 aa. Equivalent to Rv1286,len: 614 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 614 aa overlap). Probable cysN/cysC bifunctional enzyme, sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) and Adenylylsulfate kinase (EC 2.7.1.25) (see first citation below), similar to CYSN_ECOLI|P23845 sulfate adenylate transferase subunit 1 from Escherichia coli (475 aa), FASTA scores: opt: 1291, E():0, (50.2% identity in 428 aa overlap). Contains 2 x PS00017 ATP/GTP-binding site motif A, PS00301 GTP-binding elongation factors signature. Q7U089 No intermediary metabolism and respiration Rv1286 NC_002945.3 Mycobrowser_v2 CDS 1438951 1439436 . + 0 Mb1318 CONSERVED HYPOTHETICAL PROTEIN Mb1318, -, len: 161 aa. Equivalent to Rv1287, len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 161 aa overlap). Conserved hypothetical protein, similar to VJEB family of proteins e.g. FASTA score: P44675|Y379_HAEIN HYPOTHETICAL PROTEIN HI0379 (150 aa), FASTA scores: opt: 213, E(): 2.5e-08, (30.0% identity in 130 aa overlap) and YJEB_ECOLI|P21498 hypothetical 15.6 kd protein in pura-vacb (141 aa), opt: 167, E(): 9.5e-06,(25.0% identity in 136 aa overlap). BELONGS TO THE UPF0074 (RFF2) FAMILY. X2BHW4,P67160 No conserved hypotheticals Rv1287 NC_002945.3 Mycobrowser_v2 CDS 1439494 1440711 . + 0 Mb1319 conserved protein Mb1319, -, len: 405 aa. Similar to Rv1288, len: 456 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 403 aa overlap). Conserved hypothetical protein, some similarity to A85B_MYCTU|P31952 antigen 85-b precursor (85b) (325 aa), FASTA scores: opt: 199, E(): 2.7e-06, (24.7% identity in 279 aa overlap). Also similar to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related to antigen 85 complex) from Corynebacterium glutamicum (657 aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa). Q7U088 No NC_002945.3 Mycobrowser_v2 CDS 1440760 1441392 . + 0 Mb1320 unknown protein Mb1320, -, len: 210 aa. Equivalent to Rv1289, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Hypothetical unknown protein. X2BHA6 No conserved hypotheticals Rv1289 NC_002945.3 Mycobrowser_v2 CDS 1444428 1446080 . + 0 Mb1324 argS PROBABLE ARGINYL-TRNA SYNTHETASE ARGS (ARGRS) (Arginine--tRNA ligase) Mb1324, argS, len: 550 aa. Equivalent to Rv1292,len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 550 aa overlap). Probable argS,Arginyl-tRNA synthetase (EC 6.1.1.19), highly similar to SYR_MYCLE|P45840 Mycobacterium leprae (550 aa), FASTA scores: opt: 3115, E(): 0, (84.9% identity in 550 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. X2BHI6,P67570 No information pathways Rv1292 NC_002945.3 Mycobrowser_v2 CDS 1447424 1448749 . + 0 Mb1326 thrA PROBABLE HOMOSERINE DEHYDROGENASE THRA Mb1326, thrA, len: 441 aa. Equivalent to Rv1294,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 441 aa overlap). Probable thrA (hom),homoserine dehydrogenase (EC 1.1.1.3), highly similar to DHOM_MYCLE|P46806 from Mycobacterium leprae (441 aa),FASTA scores: opt: 2437, E():0, (89.5% identity in 438 aa overlap). Contains PS00017 ATP/GTP-binding site motif A; PS01042 Homoserine dehydrogenase signature. BELONGS TO THE HOMOSERINE DEHYDROGENASE FAMILY. X2BHN7,P63630 No intermediary metabolism and respiration Rv1294 NC_002945.3 Mycobrowser_v2 CDS 1448746 1449828 . + 0 Mb1327 thrC threonine synthase thrc (ts) Mb1327, thrC, len: 360 aa. Equivalent to Rv1295,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable thrC,threonine synthase (EC 4.2.3.1) (see first citation below), highly similar to THRC_MYCLE|P45837 Mycobacterium leprae (360 aa), FASTA scores: opt: 2202, E(): 0, (93.9% identity in 359 aa overlap). Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. X2BHF4,P66903 No intermediary metabolism and respiration Rv1295 NC_002945.3 Mycobrowser_v2 CDS 1450046 1450996 . + 0 Mb1328 thrB PROBABLE HOMOSERINE KINASE THRB Mb1328, thrB, len: 316 aa. Equivalent to Rv1296,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 316 aa overlap). Probable thrB,homoserine kinase (EC 2.7.1.39) (see citation below),highly similar to KHSE_MYCLE|P45836 from Mycobacterium leprae (314 aa), FASTA scores, opt: 1657, E(): 0, (82.0% identity in 311 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, and PS00627 GHMP kinases putative ATP-binding domain. X2BHX2,P65225 No intermediary metabolism and respiration Rv1296 NC_002945.3 Mycobrowser_v2 CDS 1451253 1453061 . + 0 Mb1329 rho PROBABLE TRANSCRIPTION TERMINATION FACTOR RHO HOMOLOG Mb1329, rho, len: 602 aa. Equivalent to Rv1297,len: 602 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 602 aa overlap). Probable rho,transcription termination factor homolog, highly similar to many e.g. RHO_MYCLE|P45835 Mycobacterium leprae (610 aa), FASTA scores: (81.5% identity in 612 aa overlap). CONTAINS 1 RNA RECOGNITION MOTIF (RRM). X2BHJ0,P66029 No information pathways Rv1297 NC_002945.3 Mycobrowser_v2 CDS 1453544 1454617 . + 0 Mb1331 prfA PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA (RF-1) Mb1331, prfA, len: 357 aa. Equivalent to Rv1299,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 357 aa overlap). Probable prfA, peptide chain release factor 1 (rf-1), highly similar to many e.g. RF1_MYCLE|P45833 peptide chain release factor 1 (rf-1) from Mycobacterium leprae (357 aa), FASTA scores: opt: 2047, E(): 0, (89.3% identity in 356 aa overlap); also similar to Mycobacterium tuberculosis Rv3105c, prfB peptide chain release factor 2. Contains PS00745 Prokaryotic-type class I peptide chain release factors signature. BELONGS TO THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY. X2BHP1,P66017 No information pathways Rv1299 NC_002945.3 Mycobrowser_v2 CDS 1531983 1532645 . - 0 Mb1397c POSSIBLE MEMBRANE PROTEIN Mb1397c, -, len: 220 aa. Equivalent to Rv1362c,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 220 aa overlap). Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc. Q7U070 No cell wall and cell processes Rv1362c NC_002945.3 Mycobrowser_v2 CDS 1454614 1455591 . + 0 Mb1332 hemK PROBABLE HEMK PROTEIN HOMOLOG HEMK Mb1332, hemK, len: 325 aa. Equivalent to Rv1300,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). Probable hemK protein homolog (EC 2.1.1.-), homology suggests translation may start at aa 22, highly similar to many e.g. HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa), FASTA scores: opt: 936, E(): 0, (76.7% identity in 189 aa overlap). BELONGS TO THE HEMK FAMILY OF MODIFICATION METHYLASES. Q7U086 No intermediary metabolism and respiration Rv1300 NC_002945.3 Mycobrowser_v2 CDS 1456344 1457558 . + 0 Mb1334 rfe probable undecapaprenyl-phosphate alpha-n-acetylglucosaminyltransferase rfe (udp-glcnac transferase) Mb1334, rfe, len: 404 aa. Equivalent to Rv1302,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 404 aa overlap). Putative rfe,undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-),equivalent to RFE_MYCLE|P45830 Mycobacterium leprae (398 aa), FASTA scores, opt: 2285, E(): 0, (89.2% identity in 398 aa overlap). Q7U084 No cell wall and cell processes Rv1302 NC_002945.3 Mycobrowser_v2 CDS 1457815 1458300 . + 0 Mb1335 CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN Mb1335, -, len: 161 aa. Equivalent to Rv1303, len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 161 aa overlap). Conserved hypothetical transmembrane protein, highly similar to P53431|Y02N_MYCLE hypothetical Mycobacterium leprae protein (153 aa), FASTA score: opt: 636, E():0, (69.8% identity in 149 aa overlap). X2BHB8,P64802 No cell wall and cell processes Rv1303 NC_002945.3 Mycobrowser_v2 CDS 1938610 1939179 . + 0 Mb1756 CONSERVED HYPOTHETICAL PROTEIN Mb1756, -, len: 189 aa. Equivalent to Rv1727, len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 189 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins P72040|Rv3773c|MTCY13D12.07C (194 aa), FASTA scores: opt: 176, E(): 2.7e-08, (31.1% identity in 180 aa overlap); and O53801|Rv0738 (182 aa). Q7TZP7 No conserved hypotheticals Rv1727 NC_002945.3 Mycobrowser_v2 CDS 1458293 1459045 . + 0 Mb1336 atpB PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) Mb1336, atpB, len: 250 aa. Equivalent to Rv1304,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 250 aa overlap). Probable atpB, ATP synthase A chain (EC 3.6.3.14), highly similar to ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa), FASTA scores: opt: 1382, E(): 0, (84.0% identity in 250 aa overlap). Contains PS00449 ATP synthase A subunit signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS,CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3),BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE A CHAIN FAMILY. X2BHP5,P63655 No intermediary metabolism and respiration Rv1304 NC_002945.3 Mycobrowser_v2 CDS 1459094 1459339 . + 0 Mb1337 atpE PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) Mb1337, atpE, len: 81 aa. Equivalent to Rv1305,len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 81 aa overlap). Probable atpE, ATP synthase C chain (EC 3.6.3.14), highly similar to P45828|ATPL_MYCLE Mycobacterium leprae (92.6% identity in 81 aa overlap). Contains PS00605 ATP synthase C subunit signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS,CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3),BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE C CHAIN FAMILY. X2BHH4,P63692 No intermediary metabolism and respiration Rv1305 NC_002945.3 Mycobrowser_v2 CDS 1459370 1459885 . + 0 Mb1338 atpF PROBABLE ATP SYNTHASE B CHAIN ATPF Mb1338, atpF, len: 171 aa. Equivalent to Rv1306,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Probable atpF, ATP synthase B chain (EC 3.6.3.14), highly similar to ATPF_MYCLE P45827 (170 aa), FASTA scores, opt: 802, E(): 0, (79.5% identity in 171 aa overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE -AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE B CHAIN FAMILY. X2BHY3,P63657 No intermediary metabolism and respiration Rv1306 NC_002945.3 Mycobrowser_v2 CDS 1466218 1466949 . - 0 Mb1345c POSSIBLE TRANSPOSASE [SECOND PART] Mb1345c, -, len: 243 aa. Equivalent to 3' end of Rv1313c, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 243 aa overlap). Possible IS1557 transposase, similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase for insertion sequence element IS1001 from Bordetella parapertussis (406 aa), FASTA scores: opt: 254, E(): 3.3e-10, (24.9% identity in 402 aa overlap). Also similar to putative Mycobacterium tuberculosis transposases,Rv3798 and Rv0741. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts, Mb1345c and Mb1346c. Q7TTF3 No NC_002945.3 Mycobrowser_v2 CDS 1459892 1461232 . + 0 Mb1339 atpH PROBABLE ATP SYNTHASE DELTA CHAIN ATPH Mb1339, atpH, len: 446 aa. Equivalent to Rv1307,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 446 aa overlap). Probable atpH, ATP synthase delta chain (EC 3.6.3.14). This protein is much longer than that of other bacterial delta chains, the C-terminal region is homologous to delta chains while the N-terminal region is similar to B/B' subunits e.g. ATPD_STRLI|P50008 ATP synthase delta chain from Streptomyces lividans (273 aa), FASTA scores: opt: 505,E(): 5.4e-23, (35.0% identity in 277 aa overlap); and ATPF_HAEIN|P43720 ATP synthase B chain (EC 3.6.1.34) from Haemophilus influenzae (156 aa), FASTA scores: opt: 216,E(): 1.2e-06, (26.1% identity in 153 aa overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE DELTA CHAIN FAMILY. X2BHK0,P0A501 No intermediary metabolism and respiration Rv1307 NC_002945.3 Mycobrowser_v2 CDS 1461277 1462926 . + 0 Mb1340 atpA PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA Mb1340, atpA, len: 549 aa. Equivalent to Rv1308,len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 549 aa overlap). Probable atpA, ATP synthase alpha chain (EC 3.6.3.14), highly similar to ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa),FASTA scores: opt: 3233, E(): 0, (90.3% identity in 547 aa overlap). Contains PS00017 ATP/GTP-binding site motif A,PS00152 ATP synthase alpha and beta subunits signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY. X2BHC1,P63674 No intermediary metabolism and respiration Rv1308 NC_002945.3 Mycobrowser_v2 CDS 1462933 1463850 . + 0 Mb1341 atpG PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG Mb1341, atpG, len: 305 aa. Equivalent to Rv1309,len: 305 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 305 aa overlap). Probable atpG, ATP synthase gamma chain (EC 3.6.3.14), highly similar to ATPG_MYCLE|P45824 ATP synthase gamma chain from Mycobacterium leprae (298 aa), FASTA scores: opt: 1579,E():0, (83.9% identity in 305 aa overlap). Contains PS00153 ATP synthase gamma subunit signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE GAMMA CHAIN FAMILY. X2BHP9,P63672 No intermediary metabolism and respiration Rv1309 NC_002945.3 Mycobrowser_v2 CDS 1463890 1465350 . + 0 Mb1342 atpD PROBABLE ATP SYNTHASE BETA CHAIN ATPD Mb1342, atpD, len: 486 aa. Equivalent to Rv1310,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 486 aa overlap). Probable atpD, ATP synthase beta chain (EC 3.6.3.14), highly similar to ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA score: opt: 2916, E(): 0, (92.6% identity in 484 aa overlap). Contains PS00017 ATP/GTP-binding site motif A,PS00152 ATP synthase alpha and beta subunits signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY. X2BHI4,P63678 No intermediary metabolism and respiration Rv1310 NC_002945.3 Mycobrowser_v2 CDS 1465364 1465729 . + 0 Mb1343 atpC PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC Mb1343, atpC, len: 121 aa. Equivalent to Rv1311,len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 121 aa overlap). Probable atpC, ATP synthase epsilon chain (EC 3.6.3.14), highly similar to ATPE_MYCLE|P45822 Mycobacterium leprae (124 aa), FASTA scores: opt: 682, E(): 5.4e-40, (87.6% identity in 121 aa overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3),GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE EPSILON CHAIN FAMILY. X2BHY8,P63663 No intermediary metabolism and respiration Rv1311 NC_002945.3 Mycobrowser_v2 CDS 1465737 1466171 . + 0 Mb1344 CONSERVED HYPOTHETICAL SECRETED PROTEIN Mb1344, -, len: 144 aa. Equivalent to Rv1312, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Conserved hypothetical secreted protein with potential N-terminal signal sequence. Highly similar to P53432|Y02W_MYCLE hypothetical Mycobacterium leprae protein (147 aa), FASTA score: opt: 884, E(): 0, (88.4% identity in 147 aa overlap). N-terminus hydrophobic. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2 bp deletion (cg-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa). Q7U083 No cell wall and cell processes Rv1312 NC_002945.3 Mycobrowser_v2 CDS 1467707 1468288 . - 0 Mb1347c conserved protein Mb1347c, -, len: 193 aa. Equivalent to Rv1314c,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 193 aa overlap). Conserved hypothetical protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kd protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa),FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap). X2BHJ1,P64804 No conserved hypotheticals Rv1314c NC_002945.3 Mycobrowser_v2 CDS 1468357 1469613 . + 0 Mb1348 murA PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA Mb1348, murA, len: 418 aa. Equivalent to Rv1315,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 418 aa overlap). Probable murA,UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7), highly similar to many e.g. MURA_MYCLE|P45821 (418 aa), FASTA scores: opt: 2495, E(): 0, (96.2% identity in 396 aa overlap). BELONGS TO THE EPSP SYNTHASE FAMILY. MURA SUBFAMILY. X2BHZ4,P0A5L3 No cell wall and cell processes Rv1315 NC_002945.3 Mycobrowser_v2 rRNA 1469882 1471418 . + 0 rrs rrs ribosomal RNA 16S rrs, len: 1537 nt. Equivalent to rrs, len: 1537 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1537 nt overlap). 16s rRNA gene. No NC_002945.3 Mycobrowser_v2 rRNA 1471694 1474831 . + 0 rrl rrl ribosomal RNA 23S rrl, len: 3138 nt. Equivalent to rrl, len: 3138 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 3138 nt overlap). 23S rRNA gene (approximate coordinates). No NC_002945.3 Mycobrowser_v2 rRNA 1474935 1475049 . + 0 rrf rrf ribosomal RNA 5S rrf, len: 115 nt. Equivalent to rrf, len: 115 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 115 nt overlap). 5S rRNA gene. Identical to Em_ba:MT5SRR, D10035 M.tuberculosis 5S rRNA, len: 116 nt. No NC_002945.3 Mycobrowser_v2 CDS 1475169 1475666 . - 0 Mb1349c ogt methylated-dna--protein-cysteine methyltransferase ogt (6-o-methylguanine-dna methyltransferase) (o-6-methylguanine-dna-alkyltransferase) Mb1349c, ogt, len: 165 aa. Equivalent to Rv1316c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Probable ogt,methylated-dna--protein-cysteine methytransferase (EC 2.1.1.63), similar to many e.g. OGT_HAEIN|P44687 Haemophilus influenzae (190 aa), FASTA scores: opt: 405,E(): 6.5e-20, (41.9% identity in 155 aa overlap). Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. X2BHK8,P0A697 No NC_002945.3 Mycobrowser_v2 CDS 1483897 1485066 . + 0 Mb1358 fadA4 PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA4 (ACETOACETYL-COA THIOLASE) Mb1358, fadA4, len: 389 aa. Equivalent to Rv1323,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 389 aa overlap). Probable fadA4,acetyl-CoA acetyltransferase (EC 2.3.1.9), equivalent to THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase from Mycobacterium leprae (393 aa), FASTA scores: opt: 2218, E(): 0, (87.0% identity in 392 aa overlap). Also highly similar to others e.g. CAB70629.1|AL137242 probable acetoacetyl-coA thiolase from Streptomyces coelicolor (401 aa); T51772 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) [validated] from Alcaligenes latus (392 aa); etc. Some homologies indicate ATA start codon. Contains PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiolases signature 2, and PS00099 Thiolases active site. BELONGS TO THE THIOLASE FAMILY. X2BI07,P66927 No NC_002945.3 Mycobrowser_v2 CDS 1475663 1476913 . - 0 Mb1350c alkAb PUTATIVE ADA REGULATORY PROTEIN ALKAb [SECOND PART] (Regulatory protein of adaptative response) : Methylated-DNA--protein-cysteine methyltransferase (O-6-methylguanine-DNA alkyltransferase) Mb1350c, alkAb, len: 416 aa. Equivalent to the 3' end of Rv1317c, len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 416 aa overlap). Putative alkA (alternate gene name: ada),regulatory protein (EC 2.1.1.63), similar to 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from Escherichia coli (282 aa), FASTA scores, opt: 437, E(): 8.6e-22, (32.8% identity in 293 aa overlap), also similar to other ada proteins e.g. ADA_SALTY|P26189 Salmonella typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9% identity in 156 aa overlap). Contains PS00041 Bacterial regulatory proteins, araC family signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb. Q7U082 No NC_002945.3 Mycobrowser_v2 CDS 1483348 1483806 . - 0 Mb1357c conserved protein Mb1357c, -, len: 152 aa. Equivalent to Rv1322A,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 152 aa overlap). Conserved hypothetical protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. AL583921_2|ML1157 from M. leprae strain TN (155 aa), FASTA scores: opt: 771, E(): 5.1e-43, (75.3% identity in 154 aa overlap); and AL137242_2 from S. coelicolor (146 aa), FASTA scores: opt: 404, E(): 2e-19, (43.165% identity in 139 aa overlap). Q7U080 No conserved hypotheticals Rv1322A NC_002945.3 Mycobrowser_v2 CDS 1476917 1477153 . - 0 Mb1351c alkAa PUTATIVE ADA REGULATORY PROTEIN ALKAa [FIRST PART] (Regulatory protein of adaptative response) : Methylated-DNA--protein-cysteine methyltransferase (O-6-methylguanine-DNA alkyltransferase) Mb1351c, alkAa, len: 78 aa. Equivalent to the 5' end of Rv1317c, len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 78 aa overlap). Putative alkA (alternate gene name: ada),regulatory protein (EC 2.1.1.63), similar to 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from Escherichia coli (282 aa), FASTA scores, opt: 437, E(): 8.6e-22, (32.8% identity in 293 aa overlap), also similar to other ada proteins e.g. ADA_SALTY|P26189 Salmonella typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9% identity in 156 aa overlap). Contains PS00041 Bacterial regulatory proteins, araC family signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb. Q7U081 No NC_002945.3 Mycobrowser_v2 CDS 1477234 1478859 . - 0 Mb1352c POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE) Mb1352c, -, len: 541 aa. Equivalent to Rv1318c,len: 541 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 541 aa overlap). Possible adenylate cyclase (EC 4.6.1.1). Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11,(28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505,E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423,E(): 0, (68.7% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY. X2BHJ8,P63528 No intermediary metabolism and respiration Rv1318c NC_002945.3 Mycobrowser_v2 CDS 1549333 1549914 . + 0 Mb1414 pyrR PROBABLE PYRIMIDINE OPERON REGULATORY PROTEIN PYRR Mb1414, pyrR, len: 193 aa. Equivalent to Rv1379,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 193 aa overlap). Probable pyrR,pyrimidine operon regulatory protein, similar to PYRR_BACCL|P41007 pyrimidine operon regulatory protein from Bacillus caldolyticus (179 aa), FASTA scores: opt: 544, E(): 1.1e-30, (54.2% identity in 179 aa overlap). X2BHH2,P65942 No regulatory proteins Rv1379 NC_002945.3 Mycobrowser_v2 CDS 1478929 1480536 . - 0 Mb1353c POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE) Mb1353c, -, len: 535 aa. Equivalent to Rv1319c,len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 535 aa overlap). Possible adenylate cyclase (EC 4.6.1.1). Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores: opt: 254, E(): 2.4e-10,(33.3% identity in 144 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505,E(): 0, (71.0% identity in 534 aa overlap); Rv1320c|MTCY130.05c (567 aa), FASTA scores: opt: 2354,E(): 0, (66.3% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY. X2BI01,P0A4Y3 No intermediary metabolism and respiration Rv1319c NC_002945.3 Mycobrowser_v2 CDS 1506578 1506958 . - 0 Mb1378c lprD PROBABLE CONSERVED LIPOPROTEIN LPRD Mb1378c, lprD, len: 126 aa. Equivalent to Rv1343c,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 126 aa overlap). Probable lprD,conserved lipoprotein, highly similar to G466928 Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA scores, opt: 704, E(): 7.5e-36, (78.4 % identity in 125 aa overlap). Has N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U075 No NC_002945.3 Mycobrowser_v2 CDS 1480549 1482252 . - 0 Mb1354c POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE) Mb1354c, -, len: 567 aa. Equivalent to Rv1320c,len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 567 aa overlap). Possible adenylate cyclase (EC 4.6.1.1) (see second citation below). Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores: opt: 277, E(): 2e-12, (34.0% identity in 156 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2423, E(): 0, (68.7% identity in 534 aa overlap); Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2354, E(): 0, (66.3% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY. X2BHL2,P59972 No intermediary metabolism and respiration Rv1320c NC_002945.3 Mycobrowser_v2 CDS 1482314 1482994 . + 0 Mb1355 CONSERVED HYPOTHETICAL PROTEIN Mb1355, -, len: 226 aa. Equivalent to Rv1321, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Conserved hypothetical protein. Equivalent to P53524|YD21_MYCLE hypothetical protein from Mycobacterium leprae (201 aa), FASTA scores: opt: 1144, E(): 0, (87.6% identity in 193 aa overlap). Some similarity to hypothetical proteins from other organisms e.g. Y225_METJA|Q57678 Methanococcus jannaschii (263 aa), FASTA scores: E(): 6.5e-05, (25.0% identity in 212 aa overlap). X2BHD3,P59979 No conserved hypotheticals Rv1321 NC_002945.3 Mycobrowser_v2 CDS 1483017 1483313 . + 0 Mb1356 CONSERVED HYPOTHETICAL PROTEIN Mb1356, -, len: 98 aa. Equivalent to Rv1322, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 98 aa overlap). Conserved hypothetical protein. X2BHR5 No conserved hypotheticals Rv1322 NC_002945.3 Mycobrowser_v2 CDS 1485196 1486110 . + 0 Mb1359 POSSIBLE THIOREDOXIN Mb1359, -, len: 304 aa. Equivalent to Rv1324, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 304 aa overlap). Possible thioredoxin (EC 1.-.-.-), similar to several e.g. U00014|Q49716 TRXA from Mycobacterium leprae (255 aa), FASTA scores: opt: 1014, E(): 0, (69.7% identity in 228 aa overlap); THIO_RHOSH|P08058 TrxA from Rhodobacter sphaeroides (105 aa), FASTA scores: opt 196, E(): 1.9e-06, (33.0% identity in 103 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. X2BHL7,P64808 No intermediary metabolism and respiration Rv1324 NC_002945.3 Mycobrowser_v2 CDS 1486189 1488000 . - 0 Mb1360c PE_PGRS24 pe-pgrs family protein pe_pgrs24 Mb1360c, PE_PGRS24, len: 603 aa. Equivalent to Rv1325c, len: 603 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 603 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of ala-, gly-rich proteins, similar to many e.g. YQ04_MYCTU|P71933 hypothetical 63.1 kd glycine-rich protein (778 aa), FASTA scores: E(): 0, (52.3% identity in 724 aa overlap). Q7U079 No NC_002945.3 Mycobrowser_v2 CDS 1488152 1490347 . - 0 Mb1361c glgB 1,4-alpha-glucan branching enzyme glgb (glycogen branching enzyme) Mb1361c, glgB, len: 731 aa. Equivalent to Rv1326c,len: 731 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 731 aa overlap). Probable glgB,1,4-alpha-glucan branching enzyme (EC 2.4.1.18), similar to others e.g. GLGB_ECOLI|P07762 Escherichia coli (728 aa), FASTA scores: opt: 2330, E(): 0, (48.7% identity in 719 aa overlap). Similar to other Mycobacterium tuberculosis putative alpha-glucan branching enzymes Rv1562c, Rv1563c. BELONGS TO FAMILY OF 13 GLYCOSYL HYDROLASES, ALSO KNOWN AS THE ALPHA-AMYLASE FAMILY. X2BHS4,P59816 No NC_002945.3 Mycobrowser_v2 CDS 1490355 1492460 . - 0 Mb1362c glgE PROBABLE GLUCANASE GLGE Mb1362c, glgE, len: 701 aa. Equivalent to Rv1327c,len: 701 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 701 aa overlap). Probable glgE,glucanase, similar to AF172946|AF172946_2 putative glucanase GlgE from Mycobacterium smegmatis (697 aa),FASTA scores: opt: 3816, E(): 0, (78.5% identity in 692 aa overlap). Similar to putative alpha-amylases e.g. Q9L1K2 Streptomyces coelicolor (675 aa), FASTA scores: opt: 2243,E(): 7.4e-132, (54.2% identity in 684 aa overlap). Start changed since original submission (-36) based on similarity to GlgE of Mycobacterium smegmatis; previous start at position 1494531. X2BHK7,P63532 No NC_002945.3 Mycobrowser_v2 CDS 1492599 1495190 . + 0 Mb1363 glgP PROBABLE GLYCOGEN PHOSPHORYLASE GLGP Mb1363, glgP, len: 863 aa. Equivalent to Rv1328,len: 863 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 863 aa overlap). Probable glgP,glycogen phosphorylase (EC 2.4.1.1), similar to many e.g. PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus influenzae (821 aa), FASTA scores: E(): 6.9e-08, (25.6% identity in 675 aa overlap). BELONGS TO THE GLYCOGEN PHOSPHORYLASE FAMILY. X2BI15,Q7U078 No intermediary metabolism and respiration Rv1328 NC_002945.3 Mycobrowser_v2 CDS 1495230 1497224 . - 0 Mb1364c dinG probable atp-dependent helicase ding Mb1364c, dinG, len: 664 aa. Equivalent to Rv1329c,len: 664 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 664 aa overlap). Probable dinG,ATP-dependent helicase homolog, similar to several e.g. DING_HAEIN|P44680 probable ATP-dependent helicase ding from Haemophilus influenzae (640 aa), FASTA scores: opt: 685, E(): 2.3e-38, (32.8% identity in 644 aa overlap). Contains PS00017 ATP/GTP-binding site motif A. X2BHM2,P64315 No NC_002945.3 Mycobrowser_v2 CDS 1497248 1498594 . - 0 Mb1365c pncb1 nicotinic acid phosphoribosyltransferase pncb1 Mb1365c, -, len: 448 aa. Equivalent to Rv1330c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 448 aa overlap). Conserved hypothetical protein, similar to others and also several nicotinate phosphoribosyltransferases e.g. O32090 YUEK PROTEIN from Bacillus subtilis (490 aa), FASTA scores: E(): 8.6e-22,(37.9% identity in 369 aa overlap). Also similar to M. tuberculosis Rv0573c|MTV039.11c (38.0% identity in 437 aa overlap). Start changed since original submission based on similarity; previous start at position 1500740 (-61 aa). Q7U077 No intermediary metabolism and respiration Rv1330c NC_002945.3 Mycobrowser_v2 CDS 1498696 1499001 . + 0 Mb1366 CONSERVED HYPOTHETICAL PROTEIN Mb1366, -, len: 101 aa. Equivalent to Rv1331, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 101 aa overlap). Conserved hypothetical protein, highly similar to U00014|ML014 B1549_C2_207 from Mycobacterium leprae (94 aa), FASTA scores: opt: 573, E(): 2.9e-40, (90.3% identity in 93 aa overlap). Similar to AL096852|SCE19A_16 hypothetical protein from Streptomyces coelicolor (105 aa), FASTA scores: opt: 377, E(): 2.9e-22,(60.0% identity in 105 aa overlap). X2BHT0,P67648 No conserved hypotheticals Rv1331 NC_002945.3 Mycobrowser_v2 CDS 1498961 1499617 . + 0 Mb1367 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1367, -, len: 218 aa. Equivalent to Rv1332, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 218 aa overlap). Possible regulatory protein, high similarity to ML014|U00014 from Mycobacterium leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E(): 0, (75.6% identity in 221 aa overlap). Helix turn helix motif fram aa 8-29 (+3.03 SD). X2BHL1 No regulatory proteins Rv1332 NC_002945.3 Mycobrowser_v2 CDS 1499634 1500668 . + 0 Mb1368 PROBABLE HYDROLASE Mb1368, -, len: 344 aa. Equivalent to Rv1333, len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 344 aa overlap). Possible hydrolase (EC 3.-.-.-), similar to Q57326|D26094 endo-type 6-aminohexanoate oligomer hydrolase (355 aa), fasta scores: E(): 1.4e-10, (31.9% identity in 339 aa overlap). Equivalent to P53425|YD33_MYCLE HYPOTHETICAL 36.1 KD PROTEIN B154 Mycobacterium leprae (362 aa), FASTA scores: opt: 1735, E(): 0, (76.7% identity in 352 aa overlap). X2BI21,P64812 No intermediary metabolism and respiration Rv1333 NC_002945.3 Mycobrowser_v2 CDS 1501429 1502400 . + 0 Mb1371 cysM cysteine synthase b cysm (csase b) (o-phosphoserine sulfhydrylase b) (o-phosphoserine (thiol)-lyase b) Mb1371, cysM, len: 323 aa. Equivalent to Rv1336,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 323 aa overlap). Probable cysM, cysteine synthase B (EC 4.2.99.8), similar to many e.g. CYSM_ECOLI|P16703 Escherichia coli (303 aa), FASTA scores: opt: 720, E(): 4.6e-40, (41.1% identity in 302 aa overlap). Also similar to other Mycobacterium tuberculosis cysteine synthase subunits e.g. Rv1077, Rv2334, Rv0848,etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. X2BHT6,P63874 No intermediary metabolism and respiration Rv1336 NC_002945.3 Mycobrowser_v2 CDS 1503952 1504773 . + 0 Mb1374 conserved protein Mb1374, -, len: 273 aa. Equivalent to Rv1339, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Conserved hypothetical protein, highly similar to Y211_MYCLE|P50474 hypothetical protein b1549_c2_211 from Mycobacterium leprae (284 aa),FASTA scores: opt: 1672, E(): 0, (86.2% identity in 276 aa overlap). Also similar to AL096852|SCE19A.08 hypothetical protein from Streptomyces coelicolor (250 aa), FASTA scores: opt: 630, E(): 0, (42.2% identity in 256 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins Rv3796, Rv2407. X2BHN1,P66874 No conserved hypotheticals Rv1339 NC_002945.3 Mycobrowser_v2 CDS 1532642 1533427 . - 0 Mb1398c POSSIBLE MEMBRANE PROTEIN Mb1398c, -, len: 261 aa. Equivalent to Rv1363c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 261 aa overlap). Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv1362c|MTCY02B10.26c (25.9% identity in 216 aa overlap ); Rv1972|MTV051.10 and Rv0177 etc. Q7U069 No cell wall and cell processes Rv1363c NC_002945.3 Mycobrowser_v2 CDS 1504790 1505569 . + 0 Mb1375 rphA PROBABLE RIBONUCLEASE RPHA (RNase PH) (tRNA nucleotidyltransferase) Mb1375, rphA, len: 259 aa. Equivalent to Rv1340,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 259 aa overlap). Probable rphA,Ribonuclease ph (EC 2.7.7.56), highly similar to others e.g. RNPH_MYCLE|P37939 from Mycobacterium leprae (259 aa),FASTA scores: opt: 1524, E(): 0, (88.8% identity in 259 aa overlap). BELONGS TO THE RNASE PH FAMILY. X2BHE6,Q7U076 No information pathways Rv1340 NC_002945.3 Mycobrowser_v2 CDS 1505608 1506222 . + 0 Mb1376 conserved protein Mb1376, -, len: 204 aa. Equivalent to Rv1341, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 204 aa overlap). Conserved hypothetical protein, equivalent to ML014|U00014 hypothetical protein B1549_C2_213 from Mycobacterium leprae (285 aa), FASTA scores: opt: 1073, E(): 0, (83.0% identity in 206 aa overlap). Some similarity to P52061|YGGV_ECOLI HYPOTHETICAL PROTEIN yggV (197 aa), FASTA scores: opt: 521, E(): 7.9e-27, (46.0% identity in 200 aa overlap). X2BHU2,P64308 No conserved hypotheticals Rv1341 NC_002945.3 Mycobrowser_v2 CDS 1507316 1508881 . + 0 Mb1380 mbtm probable fatty acyl-amp ligase mbtm Mb1380, fadD33, len: 521 aa. Equivalent to Rv1345,len: 521 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 521 aa overlap). Possible fadD33,polyketide synthase, similar to N-terminus of T34918 polyketide synthase from Streptomyces coelicolor (2297 aa); and PKSJ_BACSU|P40806 putative polyketide biosynthesis protein from Bacillus subtilis (557 aa),FASTA scores: opt: 537, E(): 8.2e-27, (27.1% identity in 468 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis eg Rv1013|MTCI237.30|MTCY10G2.36c|pks16 PUTATIVE POLYKETIDE SYNTHASE (544 aa); etc. X2BHE8,P0A4X9 No NC_002945.3 Mycobrowser_v2 CDS 1508881 1510041 . + 0 Mb1381 mbtn acyl-coa dehydrogenase mbtn Mb1381, fadE14, len: 386 aa. Equivalent to Rv1346,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 386 aa overlap). Possible fadE14,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. NP_251579.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (386 aa); NP_036951.1|NM_012819|ACDL_RAT|P15650 acyl Coenzyme A dehydrogenase (long chain) from Rattus norvegicus (430 aa), FASTA scores: opt: 414, E(): 1.2e-18, (26.1% identity in 376 aa overlap); etc. X2BHU7,P63432 No NC_002945.3 Mycobrowser_v2 CDS 1510008 1510640 . - 0 Mb1382c mbtk lysine n-acetyltransferase mbtk Mb1382c, -, len: 210 aa. Equivalent to Rv1347c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Conserved hypothetical protein, some similarity to the C-terminus of malonyl-coenzyme A carboxylases e.g. G545170 malonyl-coenzyme A carboxylase (417 aa), FASTA scores: opt: 392, E(): 4.9 e-20, (35.6% identity in 174 aa overlap). X2BHM4,P64820 No lipid metabolism Rv1347c NC_002945.3 Mycobrowser_v2 CDS 1541503 1542684 . + 0 Mb1406 CONSERVED HYPOTHETICAL PROTEIN Mb1406, -, len: 393 aa. Equivalent to Rv1372, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Conserved hypothetical protein, similar to several chalcone synthases e.g. CHS2_GERHY|P48391 chalcone synthase 2 from gerbra hybrid (402 aa), FASTA scores: opt: 511, E(): 7e-26, (28.4% identity in 380 aa overlap). Also similar to M. tuberculosis hypothetical chalcone synthases, Rv1665,Rv1660. X2BHP7,Q7U064 No conserved hypotheticals Rv1372 NC_002945.3 Mycobrowser_v2 CDS 1511082 1513661 . + 0 Mb1383 irta iron-regulated transporter irta Mb1383, -, len: 859 aa. Equivalent to Rv1348, len: 859 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 859 aa overlap). Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), similar to HMT1_SCHPO|Q02592 heavy metal tolerance protein precursor from Schizosaccharomyces pombe (830 aa), FASTA scores: opt: 806, E(): 5.1e-39, (32.9% identity in 504 aa overlap); etc. Also similar to MTCY02B10.13 from Mycobacterium tuberculosis, FASTA score: (31.9% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BI38,P63392 No cell wall and cell processes Rv1348 NC_002945.3 Mycobrowser_v2 CDS 1513658 1515397 . + 0 Mb1384 irtb iron-regulated transporter irtb Mb1384, -, len: 579 aa. Equivalent to Rv1349, len: 579 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 579 aa overlap). Probable drugs-transport transmembrane ATP binding protein ABC transporter (see citation below), most similar to YWJA_BACSU|P45861 hypothetical ABC transporter from Bacillus subtilis (575 aa), FASTA scores: opt: 721, E(): 1.8e-35, (28.9% identity in 567 aa overlap); etc. Also similar to MTCY02B10.12 from Mycobacterium tuberculosis,FASTA score: (31.9% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BHN8,P63394 No cell wall and cell processes Rv1349 NC_002945.3 Mycobrowser_v2 CDS 1515526 1516269 . + 0 Mb1385 fabG2 probable 3-oxoacyl-[acyl-carrier protein] reductase fabg2 (3-ketoacyl-acyl carrier protein reductase) Mb1385, fabG2, len: 247 aa. Equivalent to Rv1350,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 247 aa overlap). Probable fabG2,3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100),highly similar to many e.g. NP_350157.1|NC_003030 3-ketoacyl-acyl carrier protein reductase from Clostridium acetobutylicum (249 aa); NP_229523.1|NC_000853 3-oxoacyl-(acyl carrier protein) reductase from Thermotoga maritima (246 aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. X2BHF2,P66782 No NC_002945.3 Mycobrowser_v2 CDS 1516266 1516595 . + 0 Mb1386 HYPOTHETICAL PROTEIN Mb1386, -, len: 109 aa. Equivalent to Rv1351, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 109 aa overlap). Hypothetical unknown protein. X2BHV3 No conserved hypotheticals Rv1351 NC_002945.3 Mycobrowser_v2 CDS 1516798 1517169 . + 0 Mb1387 conserved protein Mb1387, -, len: 123 aa. Equivalent to Rv1352, len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 123 aa overlap). Conserved hypothetical protein, some similarity to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa overlap). X2BHN0 No conserved hypotheticals Rv1352 NC_002945.3 Mycobrowser_v2 CDS 1517235 1518020 . - 0 Mb1388c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1388c, -, len: 261 aa. Equivalent to Rv1353c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Probable transcriptional regulatory protein, similar to TER1_ECOLI|P03038 tetracycline repressor protein class A from Escherichia coli (216 aa), FASTA scores, opt: 231,E(): 1.6e-08, (31.3% identity in 211 aa overlap). Helix turn helix motif present at aa 3859 (+3.59 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. X2BI41,P67435 No regulatory proteins Rv1353c NC_002945.3 Mycobrowser_v2 CDS 1518040 1519911 . - 0 Mb1389c CONSERVED HYPOTHETICAL PROTEIN Mb1389c, -, len: 623 aa. Equivalent to Rv1354c,len: 623 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 623 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins e.g. the C-terminus of G1001455 Synechocystis sp. (1244 aa), FASTA scores: opt: 933, E(): 0, (36.8% identity in 462 aa overlap); also similar to Rv1357c|MTCY02B10.21c (34.0% identity in 253 aa overlap). X2BHP2,P64826 No conserved hypotheticals Rv1354c NC_002945.3 Mycobrowser_v2 CDS 1519920 1522067 . - 0 Mb1390c moeY POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY Mb1390c, moeY, len: 715 aa. Equivalent to Rv1355c,len: 715 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 715 aa overlap). Possible moeY,Molybdopterin biosynthesis protein, very weak similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis moeb protein (249 aa), FASTA scores, opt: 180, E(): 8.5e-05,(29.3% identity in 174 aa overlap). Q7U074 No NC_002945.3 Mycobrowser_v2 CDS 1522064 1522855 . - 0 Mb1391c HYPOTHETICAL PROTEIN Mb1391c, -, len: 263 aa. Equivalent to Rv1356c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 263 aa overlap). Hypothetical unknown protein. X2BHV6 No conserved hypotheticals Rv1356c NC_002945.3 Mycobrowser_v2 CDS 1523328 1524251 . - 0 Mb1392c CONSERVED HYPOTHETICAL PROTEIN Mb1392c, -, len: 307 aa. Equivalent to Rv1357c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Conserved hypothetical protein, similar to members of the YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical protein Y4ll from Rhizobium sp. (827 aa), FASTA scores: E(): 0, (37.7% identity in 257 aa overlap), also similar to Rv1354c|MTCY02B10.18c (34.0% identity in 253 aa overlap). BELONGS TO THE YEGE/YHDA/YHJK/YJCC FAMILY. X2BHN5,P64830 No conserved hypotheticals Rv1357c NC_002945.3 Mycobrowser_v2 CDS 1524647 1528126 . + 0 Mb1393 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1393, -, len: 1159 aa. Equivalent to Rv1358, len: 1159 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 1159 aa overlap). Probable transcriptional regulatory protein, some similarity to AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores: opt: 210,E(): 5.5e-06, (27.5% identity in 739 aa overlap). Similar also to Rv0890C|MTCY31.18c (65.5% identity in 884 aa overlap) and to Rv1359|MTCY02B10.23 (43.7% identity in 197 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, PS00622 Bacterial regulatory proteins, luxR family signature. Helix turn helix motif present at aa 1116-1137,(Score 1291, +3.59 SD). Q7U073 No regulatory proteins Rv1358 NC_002945.3 Mycobrowser_v2 CDS 1528208 1528960 . + 0 Mb1394 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1394, -, len: 250 aa. Equivalent to Rv1359, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap). Q7U072 No regulatory proteins Rv1359 NC_002945.3 Mycobrowser_v2 CDS 1529383 1530405 . + 0 Mb1395 PROBABLE OXIDOREDUCTASE Mb1395, -, len: 340 aa. Equivalent to Rv1360, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 340 aa overlap). Probable oxidoreductase (EC 1.-.-.-). Similar to Q49598|G1002714 coenzyme F420-dependent n5, n10-methylenetetrahydromethanopterin reductase from Methanopyrus kandleri (349 aa), FASTA scores: opt: 264, E(): 4.4e-11, (26.3% identity in 323 aa overlap). X2BHG0,P64832 No intermediary metabolism and respiration Rv1360 NC_002945.3 Mycobrowser_v2 CDS 1530478 1531668 . - 0 Mb1396c PPE19 ppe family protein ppe19 Mb1396c, PPE19, len: 396 aa. Similar to Rv1361c,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(92.9% identity in 396 aa overlap). PPE19 (alternate gene name: mtb39b). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to many e.g. Rv1196|MTCI364.08|PPE18, FASTA scores: E(): 0,(84.9% identity in 397 aa overlap); MTCY274.23c (42.3% identity in 416 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site. Note that expression of Rv1361c was demonstrated in lysates by immunodetection (see first citation below). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the PPE19 gene contains nine substitutions compared to Mycobacterium tuberculosis strain H37Rv. Q7U071 No NC_002945.3 Mycobrowser_v2 CDS 1533718 1535679 . - 0 Mb1399c possible sigma factor regulatory protein Mb1399c, -, len: 653 aa. Equivalent to Rv1364c,len: 653 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 653 aa overlap). Conserved hypothetical protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa),FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 aa overlap). Q7U068 No information pathways Rv1364c NC_002945.3 Mycobrowser_v2 CDS 1535818 1536204 . - 0 Mb1400c rsfa anti-anti-sigma factor rsfa (anti-sigma factor antagonist) (regulator of sigma f a) Mb1400c, -, len: 128 aa. Equivalent to Rv1365c,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 128 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08 (148 aa), FASTA scores: E(): 0, (53.6% identity in 125 aa overlap); Rv1904,Rv3687c. Weak similarity to putative anti-anti-sigma factors e.g. AF134889|AF134889_1 Streptomyces coelicolor (113 aa), FASTA scores: opt: 137, E(): 0.004, (26.0% identity in 100 aa overlap). Q7U067 No information pathways Rv1365c NC_002945.3 Mycobrowser_v2 CDS 1537215 1537475 . + 0 Mb1401A Conserved protein Mb1401A, len: 86 aa. Equivalent to Rv1366A len: 86 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 86 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BHP3 No conserved hypotheticals Rv1366A NC_002945.3 Mycobrowser_v2 CDS 1537547 1538680 . - 0 Mb1402c conserved protein Mb1402c, -, len: 377 aa. Equivalent to Rv1367c,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 377 aa overlap). Conserved hypothetical protein. Some similarity to penicillin binding proteins e.g. PBPE_BACSU|P32959 penicillin-binding protein 4* (pbp 4*) from Bacillus subtilis (451 aa), FASTA scores: E(): 6.9e-06, (23.6% identity in 373 aa overlap). Similar to AL031107|SC5A7.06 hypothetical protein from Streptomyces coelicolor (409 aa), FASTA scores: opt: 675, E(): 0,(40.4% identity in 339 aa overlap). Q7U066 No conserved hypotheticals Rv1367c NC_002945.3 Mycobrowser_v2 CDS 1686880 1687071 . - 0 Mb1536c conserved protein Mb1536c, -, len: 63 aa. Equivalent to Rv1498A, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 63 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. from Streptomyces coelicolor, Sinorhizobium meliloti and Pseudomonas aeruginosa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa). Q7TZY9 No conserved hypotheticals Rv1498A NC_002945.3 Mycobrowser_v2 CDS 1539055 1539840 . + 0 Mb1403 lprF probable conserved lipoprotein lprf Mb1403, lprF, len: 261 aa. Equivalent to Rv1368,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Probable lipoprotein lprF, similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|Y08C_MYCTU|Q11049 hypothetical 26.4 kd protein cy50.12. (257 aa), FASTA scores: opt: 286,E(): 5.3e-11, (26.3% identity in 270 aa overlap), also Rv1411c|MTCY21B4.28c, (32.8% identity in 253 aa overlap) and Rv2945c. Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). BELONGS TO THE LPPX/LPRAFG FAMILY OF LIPOPROTEINS. X2BHQ5,P65315 No cell wall and cell processes Rv1368 NC_002945.3 Mycobrowser_v2 CDS 1540036 1540989 . + 0 Mb1404 PROBABLE CONSERVED MEMBRANE PROTEIN Mb1404, -, len: 317 aa. Similar to 5' end of Rv1371, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (90.9% identity in 166 aa overlap). Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052,(22.4% identity in 438 aa overlap); and Homo sapiens. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and Mb1405, with the latter being the more likely product. No NC_002945.3 Mycobrowser_v2 CDS 1540511 1541506 . + 0 Mb1405 PROBABLE CONSERVED MEMBRANE PROTEIN Mb1405, -, len: 331 aa. Equivalent to 3' end of Rv1371, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 331 aa overlap). Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052,(22.4% identity in 438 aa overlap); and Homo sapiens. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and Mb1405, with the latter being the more likely product. Q7U065 No NC_002945.3 Mycobrowser_v2 CDS 1560373 1560945 . + 0 Mb1423 mihF PUTATIVE INTEGRATION HOST FACTOR MIHF Mb1423, mihF, len: 190 aa. Equivalent to Rv1388,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 190 aa overlap). Putative mihF,integration host factor. Almost identical to, but longer than, P96802|U75344 Mycobacterium smegmatis integration host factor (mIHF) for mycobacteriophage L5 (105 aa),FASTA scores: E(): 0, (96.1% identity in 102 aa overlap). Q7U052 No information pathways Rv1388 NC_002945.3 Mycobrowser_v2 CDS 1542690 1543487 . + 0 Mb1407 GLYCOLIPID SULFOTRANSFERASE [FIRST PART] Mb1407, -, len: 265 aa. Equivalent to the 5' end of Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 154 aa overlap). Glycolipid sulfotransferase (EC 2.8.2.-) (see citation below); slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity in 294 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Q7U063 No NC_002945.3 Mycobrowser_v2 CDS 1543153 1543671 . + 0 Mb1408 GLYCOLIPID SULFOTRANSFERASE [SECOND PART] Mb1408, -, len: 172 aa. Equivalent to the 3' end of Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 172 aa overlap). Glycolipid sulfotransferase (EC 2.8.2.-) (see citation below); slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity in 294 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408. No NC_002945.3 Mycobrowser_v2 CDS 1543751 1544209 . - 0 Mb1409c HYPOTHETICAL PROTEIN Mb1409c, -, len: 152 aa. Equivalent to Rv1374c,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 152 aa overlap). Hypothetical unknown protein. Q7U062 No conserved hypotheticals Rv1374c NC_002945.3 Mycobrowser_v2 CDS 1544511 1545830 . + 0 Mb1410 CONSERVED HYPOTHETICAL PROTEIN Mb1410, -, len: 439 aa. Equivalent to Rv1375, len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 439 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. Q52871|U39409 Rhizobium leguminosarum (420 aa), FASTA scores: E(): 2e-30, (34.4% identity in 378 aa overlap). Q7U061 No conserved hypotheticals Rv1375 NC_002945.3 Mycobrowser_v2 CDS 1545827 1547320 . + 0 Mb1411 CONSERVED HYPOTHETICAL PROTEIN Mb1411, -, len: 497 aa. Equivalent to Rv1376, len: 497 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 497 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins from several organisms e.g. Q52872|U39409 Rhizobium leguminosarum (247 aa), FASTA scores: E(): 2.1e-12, (34.7% identity in 219 aa overlap). Q7U060 No conserved hypotheticals Rv1376 NC_002945.3 Mycobrowser_v2 CDS 1547258 1547896 . - 0 Mb1412c PUTATIVE TRANSFERASE Mb1412c, -, len: 212 aa. Equivalent to Rv1377c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 212 aa overlap). Putative transferase (EC 2.-.-.-), similar to YQEM_BACSU|P54458 hypothetical 28.3 kd protein from Bacillus subtilis (247 aa), FASTA scores: opt: 221, E(): 7.6e-08, (30.6% identity in 144 aa overlap); some similarity to methyltransferases, also similar to Mycobacterium tuberculosis hypothetical proteins Rv0560c, Rv3699, and Rv2675c (~ 39.1% identity in 197 aa overlap). Q7U059 No intermediary metabolism and respiration Rv1377c NC_002945.3 Mycobrowser_v2 CDS 1547907 1549334 . - 0 Mb1413c CONSERVED HYPOTHETICAL PROTEIN Mb1413c, -, len: 475 aa. Equivalent to Rv1378c,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 475 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C (424 aa),FASTA scores: E(): 0, (73.0% identity in 429 aa overlap). Q7U058 No conserved hypotheticals Rv1378c NC_002945.3 Mycobrowser_v2 CDS 1561080 1561706 . + 0 Mb1424 gmk PROBABLE GUANYLATE KINASE GMK Mb1424, gmk, len: 208 aa. Equivalent to Rv1389,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 208 aa overlap). Probable gmk, guanylate kinase (EC 2.7.4.8), similar to e.g. KGUA_ECOLI|P24234 guanylate kinase from Escherichia coli (207 aa), FASTA scores: opt: 424, E(): 6.6e-20, (35.9% identity in 184 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00856 Guanylate kinase signature. BELONGS TO THE GUANYLATE KINASE FAMILY. X2BHH9,P0A5I5 No intermediary metabolism and respiration Rv1389 NC_002945.3 Mycobrowser_v2 CDS 1549911 1550870 . + 0 Mb1415 pyrB PROBABLE ASPARTATE CARBAMOYLTRANSFERASE PYRB (ATCase) (Aspartate transcarbamylase) Mb1415, pyrB, len: 319 aa. Equivalent to Rv1380,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 319 aa overlap). Probable pyrB,aspartate carbamoyltransferase (EC 2.1.3.2), similar to many e.g. PYRB_BACCL|P41008 aspartate carbamoyltransferase from Bacillus caldolyticus (308 aa), FASTA scores, opt: 639, E(): 7.3e-36, (39.5% identity in 311 aa overlap). Contains PS00097 Aspartate and ornithine carbamoyltransferases signature. BELONGS TO THE ATCASES/OTCASES FAMILY. X2BHX3,P65614 No intermediary metabolism and respiration Rv1380 NC_002945.3 Mycobrowser_v2 CDS 1550867 1552159 . + 0 Mb1416 pyrC PROBABLE DIHYDROOROTASE PYRC (DHOase) Mb1416, pyrC, len: 430 aa. Equivalent to Rv1381,len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 430 aa overlap). Probable pyrC,dihydroorotase (EC 3.5.2.3), similar to many e.g. PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap). Contains PS00483 Dihydroorotase signature 2. BELONGS TO THE DHOASE FAMILY. SUBFAMILY 2. X2BHQ7,Q7U057 No intermediary metabolism and respiration Rv1381 NC_002945.3 Mycobrowser_v2 CDS 1552156 1552653 . + 0 Mb1417 PROBABLE EXPORT OR MEMBRANE PROTEIN Mb1417, -, len: 165 aa. Equivalent to Rv1382, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Possible exported or membrane protein, hydrophobic domain at N-terminus. Q7U056 No cell wall and cell processes Rv1382 NC_002945.3 Mycobrowser_v2 CDS 1552650 1553780 . + 0 Mb1418 carA PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN CARA (Carbamoyl-phosphate synthetase glutamine chain) Mb1418, carA, len: 376 aa. Equivalent to Rv1383,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 376 aa overlap). Probable carA,Carbamoyl-phosphate synthase small chain (EC 6.3.5.5),similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate synthase small chain from Escherichia coli (382 aa), FASTA scores: opt: 796, E(): 0, (45.5% identity in 382 aa overlap). Contains PS00442 Glutamine amidotransferases class-I active site. THE GATASE DOMAIN BELONGS TO TYPE-1 GLUTAMINE AMIDOTRANSFERASES. SUBUNIT: COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE. X2BHS1,Q7U055 No intermediary metabolism and respiration Rv1383 NC_002945.3 Mycobrowser_v2 CDS 1568806 1570164 . - 0 Mb1431c PE_PGRS25 pe-pgrs family protein pe_pgrs25 Mb1431c, PE_PGRS25, len: 452 aa. Similar to Rv1396c, len: 576 aa, from Mycobacterium tuberculosis strain H37Rv, (78.1% identity in 576 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, strong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa),FASTA scores: opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A,similar to other PGRS-type sequences. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa). Q7U049 No NC_002945.3 Mycobrowser_v2 CDS 1553780 1557127 . + 0 Mb1419 carB PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN CARB (Carbamoyl-phosphate synthetase ammonia chain) Mb1419, carB, len: 1115 aa. Equivalent to Rv1384,len: 1115 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1115 aa overlap). Probable carB,Carbamoyl-phosphate synthase large chain (EC 6.3.5.5),similar to many e.g. CARB_ECOLI|P00968 E. coli (1072 aa),FASTA scores: E(): 0, (52.3% identity in 1118 aa overlap). Contains two PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00866 Carbamoyl-phosphatesynthase subdomain signature 1. SUBUNIT: COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA,WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE. X2BHH6,Q7U054 No NC_002945.3 Mycobrowser_v2 CDS 1557124 1557948 . + 0 Mb1420 pyrF PROBABLE OROTIDINE 5'-PHOSPHATE DECARBOXYLASE PYRF (OMP decarboxylase) (OMPdecase) Mb1420, pyrF, len: 274 aa. Equivalent to Rv1385,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Probable pyrF,orotidine 5'-phosphate decarboxylase (EC 4.1.1.23),identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. BELONGS TO THE OMP DECARBOXYLASE FAMILY. X2BHX9,P0A5M7 No intermediary metabolism and respiration Rv1385 NC_002945.3 Mycobrowser_v2 CDS 1558143 1558451 . + 0 Mb1421 PE15 pe family protein pe15 Mb1421, PE15, len: 102 aa. Equivalent to Rv1386,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 102 aa overlap). Member of Mycobacterium tuberculosis PE family (see first citation below), similar to many e.g. G913039 ORF 3' OF PGRS TANDEM REPEAT (polymorphic GC-rich sequence) (100 aa), FASTA scores: opt: 149, E(): 0.0013, (31.5% identity in 92 aa overlap); also similar to Q49943|U1756A (99 aa) (34.7% identity in 95 aa overlap) and G466937|U1620K (100 aa) (36.2% identity in 69 aa overlap). X2BHR2 No PE/PPE Rv1386 NC_002945.3 Mycobrowser_v2 CDS 1558448 1560067 . + 0 Mb1422 PPE20 ppe family protein ppe20 Mb1422, PPE20, len: 539 aa. Equivalent to Rv1387,len: 539 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 539 aa overlap). Member of Mycobacterium tuberculosis PPE family of proteins, similar to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein cy251.15 (463 aa), FASTA scores: E(): 4.2e-26,(37.7% identity in 531 aa overlap); similar also to MTCY274.23c (37.5% identity in 168 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. Q7U053 No NC_002945.3 Mycobrowser_v2 CDS 1562120 1563376 . + 0 Mb1426 dfp PROBABLE DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN HOMOLOG DFP Mb1426, dfp, len: 418 aa. Equivalent to Rv1391,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 418 aa overlap). Probable dfp,DNA/pantothenate metabolism flavoprotein homolog, similar to many e.g. DFP_ECOLI|P24285 Escherichia coli (430 aa),FASTA scores: opt: 763, E(): 0, (40.2% identity in 408 aa overlap). X2BHR8,P67734 No intermediary metabolism and respiration Rv1391 NC_002945.3 Mycobrowser_v2 CDS 1563504 1564715 . + 0 Mb1427 metK PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE METK (MAT) (AdoMet synthetase) (Methionine adenosyltransferase) Mb1427, metK, len: 403 aa. Equivalent to Rv1392,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 403 aa overlap). Probable metK,S-adenosylmethionine synthetase (EC 2.5.1.6), similar to many e.g. METK_STAAU|P50307 Staphylococcus aureus (397 aa), FASTA scores: opt: 1484, E(): 0, (58.0% identity in 400 aa overlap). Contains PS00376 S-adenosylmethionine synthetase signature 1, PS00377 S-adenosylmethionine synthetase signature 2. BELONGS TO THE ADOMET SYNTHETASE FAMILY. X2BI76,Q7U051 No intermediary metabolism and respiration Rv1392 NC_002945.3 Mycobrowser_v2 CDS 1564788 1566266 . - 0 Mb1428c PROBABLE MONOXYGENASE Mb1428c, -, len: 492 aa. Equivalent to Rv1393c,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 492 aa overlap). Probable monooxygenase (EC 1.14.13.-), similar to others e.g. CYMO_ACISP|P12015 cyclohexanone monooxygenase (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: E(): 0, (33.0% identity in 473 aa overlap); also to Rv3083|MTCY31.20|E241788 hypothetical 55.0 kDa protein from Mycobacterium tuberculosis (495 aa) (36.3% identity in 490 aa overlap); and Rv0565c, Rv3854c, Rv3049c,Rv0892. Q7U050 No intermediary metabolism and respiration Rv1393c NC_002945.3 Mycobrowser_v2 CDS 1566263 1567648 . - 0 Mb1429c cyp132 PROBABLE CYTOCHROME P450 132 CYP132 Mb1429c, cyp132, len: 461 aa. Equivalent to Rv1394c, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 461 aa overlap). Probable cyp132, cytochrome P450 132 (EC 1.14.-.- ). Some similarity to others e.g. CP4B_HUMAN|P13584 human cytochrome p450 (511 aa), FASTA scores: opt: 486, E(): 7.4e-21, (28.6% identity in 423 aa overlap); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. MAY BELONG TO THE CYTOCHROME P450 FAMILY. X2BHI2,P59954 No intermediary metabolism and respiration Rv1394c NC_002945.3 Mycobrowser_v2 CDS 1575905 1576729 . - 0 Mb1438c PUTATIVE METHYLTRANSFERASE Mb1438c, -, len: 274 aa. Equivalent to Rv1403c,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Putative methyltransferase (EC 2.1.1.-), similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa), FASTA scores: opt: 217, E(): 1.1e-07, (37.1% identity in 105 aa overlap); similar to Rv1405c|MTCY21B4.22c (59.3% identity in 273 aa overlap) and to Rv1523, Rv2952, etc. X2BHU0,P64840 No intermediary metabolism and respiration Rv1403c NC_002945.3 Mycobrowser_v2 CDS 1567726 1568760 . + 0 Mb1430 transcriptional regulatory protein Mb1430, -, len: 344 aa. Equivalent to Rv1395, len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 344 aa overlap). Probable transcriptional regulatory protein, similar to many e.g. URER_PROMI|Q02458 urease operon transcriptional activator from Proteus mirabilis (293 aa), FASTA scores: E():1.5e-08, (41.7% identity in 84 aa overlap); YHIX_ECOLI|P37639 hypothetical transcriptional regulatory protein from Escherichia coli (274 aa), FASTA scores: opt: 238, E(): 3.5e-09, (27.3% identity in 249 aa overlap); and G296916|X68281 POSSIBLE VIRULENCE-REGULATING protein from Mycobacterium tuberculosis (339 aa), FASTA scores: opt: 228, E(): 1.9e-08, (27.0% identity in 278 aa overlap). Helix turn helix motif present, aa 261-282 (+4.68 SD). BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. 3' part corrected since first submission (-14 aa). X2BHZ0,P68912 No regulatory proteins Rv1395 NC_002945.3 Mycobrowser_v2 CDS 1571157 1572116 . - 0 Mb1434c nlhh probable non lipolytic carboxylesterase nlhh Mb1434c, lipH, len: 319 aa. Equivalent to Rv1399c,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 319 aa overlap). Possible LipH, lipase (EC 3.1.-.-), most similar to G695278 lipase like enzyme from Ralstonia eutropha (364 aa), FASTA scores: opt: 648,E(): 4.4e-34, (37.3% identity in 327 aa ov erlap), similar to Mycobacterium tuberculosis hypothetical lipases e.g. Rv2284, Rv2485c, Rv1426c, etc. Q7U047 No NC_002945.3 Mycobrowser_v2 CDS 1572141 1573103 . - 0 Mb1435c lipI PROBABLE LIPASE LIPH Mb1435c, lipI, len: 320 aa. Equivalent to Rv1400c,len: 320 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 320 aa overlap). Possible lipI, lipase (EC 3.1.-.-), most similar to G695278 lipase like enzyme (364 aa), FASTA sscores: opt: 611, E(): 3.5e-30, (36.6% identity in 352 aa overlap); similar to Mycobacterium tuberculosis hypothetical lipases e.g. Rv1399c|MTCY21B4.16c (58.1% identical in 315 aa overlap); Rv1426c, Rv2284, etc. Q7U046 No NC_002945.3 Mycobrowser_v2 CDS 1573237 1573839 . + 0 Mb1436 POSSIBLE MEMBRANE PROTEIN Mb1436, -, len: 200 aa. Equivalent to Rv1401, len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 200 aa overlap). Possible membrane protein. X2BHS7,P64838 No cell wall and cell processes Rv1401 NC_002945.3 Mycobrowser_v2 CDS 1932370 1932759 . - 0 Mb1749c vapc12 possible toxin vapc12 Mb1749c, -, len: 129 aa. Equivalent to Rv1720c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53610|Rv0065|MTV030.08 (133 aa), FASTA scores: E(): 1.5e-10, (39.1% identity in 128 aa overlap); P71550|Rv0960|MTCY10D7.14C (129 aa) and O06415|Rv0549c|MTCY25D10.28C (137 aa). Q7TZQ4 No virulence, detoxification, adaptation Rv1720c NC_002945.3 Mycobrowser_v2 CDS 1573920 1575887 . + 0 Mb1437 priA PUTATIVE PRIMOSOMAL PROTEIN N' PRIA (Replication factor Y) Mb1437, priA, len: 655 aa. Equivalent to Rv1402,len: 655 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 655 aa overlap). Putative priA,primosomal protein N'. Similar to e.g. PRIA_ECOLI|P17888 primosomal protein N' (replication factor Y) (732 aa),FASTA scores, opt: 386, E(): 1.3e-16, (27.6% identity in 711 aa overlap). Compared to other bacterial priA, it has a very divergent helicase domain. BELONGS TO THE HELICASE FAMILY. PRIA SUBFAMILY. X2BI84,P0A5A6 No information pathways Rv1402 NC_002945.3 Mycobrowser_v2 CDS 1577452 1578276 . - 0 Mb1440c PUTATIVE METHYLTRANSFERASE Mb1440c, -, len: 274 aa. Equivalent to Rv1405c,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Putative methyltransferase (EC 2.1.1.-), most similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa), FASTA scores: opt: 219, E(): 2.6e-07, (29.9% identity in 144 aa overlap); similar to Rv1403c|MTCY21B4.20c (59.3% identity in 273 aa overlap),Rv1523, Rv2952, etc. X2BI04,P64842 No intermediary metabolism and respiration Rv1405c NC_002945.3 Mycobrowser_v2 CDS 1578473 1579411 . + 0 Mb1441 fmt PROBABLE METHIONYL-TRNA FORMYLTRANSFERASE FMT Mb1441, fmt, len: 312 aa. Equivalent to Rv1406,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 312 aa overlap). Probable fmt,methionyl-tRNA formyltransferase (EC 2.1.2.9), similar to many e.g. FMT_ECOLI|P23882 Escherichia coli (314 aa),FASTA scores: opt: 616, E(): 6.7e-31, (39.3% identity in 303 aa overlap). BELONGS TO THE FMT FAMILY. X2BHT2,P64135 No information pathways Rv1406 NC_002945.3 Mycobrowser_v2 CDS 1579408 1580781 . + 0 Mb1442 fmu PROBABLE FMU PROTEIN (SUN PROTEIN) Mb1442, fmu, len: 457 aa. Equivalent to Rv1407,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 457 aa overlap). Probable fmu protein,similar to SUN_ECOLI|P36929 sun protein (fmu protein) from Escherichia coli (429 aa), FASTA scores: E(): 2.5e-20,(30.6% identity in 451 aa overlap). Q7U044 No information pathways Rv1407 NC_002945.3 Mycobrowser_v2 CDS 1580806 1581504 . + 0 Mb1443 rpe PROBABLE RIBULOSE-PHOSPHATE 3-EPIMERASE RPE (PPE) (R5P3E) (Pentose-5-phosphate 3-epimerase) Mb1443, rpe, len: 232 aa. Equivalent to Rv1408,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 232 aa overlap). Probable rpe,ribulose-phosphate 3-epimerase (EC 5.1.3.1), similar to many e.g. CXEC_ALCEU|P40117 (241 aa), FASTA scores: opt: 638, E(): 1.5e-34, (48.3% identity in 234 aa overlap); and RPE_ECOLI|P32661 ribulose-phosphate 3-epimerase (225 aa),FASTA scores: E(): 0, (46.2% identity in 221 aa overlap). Contains PS01085 Ribulose-phosphate 3-epimerase family signature 1. BELONGS TO THE RIBULOSE-PHOSPHATE 3-EPIMERASE FAMILY. X2BHU6,P65761 No intermediary metabolism and respiration Rv1408 NC_002945.3 Mycobrowser_v2 CDS 1581501 1582520 . + 0 Mb1444 ribG PROBABLE BIFUNCTIONAL riboflavin biosynthesis protein RIBG : Diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase) Mb1444, ribG, len: 339 aa. Equivalent to Rv1409,len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 339 aa overlap). Probable ribG (alternate gene name: ribD), bifunctional riboflavin biosynthesis protein, including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), similar to many e.g. RIBD_ECOLI|P25539 riboflavin-specific deaminase from Escherichia coli (367 aa), FASTA scores: E(): 0, (39.8% identity in 364 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. IN THE N-TERMINAL SECTION; BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HTP REDUCTASE FAMILY. Q7U043 No intermediary metabolism and respiration Rv1409 NC_002945.3 Mycobrowser_v2 CDS 1582517 1584073 . - 0 Mb1445c AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL MEMBRANE PROTEIN Mb1445c, -, len: 518 aa. Equivalent to Rv1410c,len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 518 aa overlap). Aminoglycoside/tetracycline-transport integral membrane protein (see citation below), member of major facilitator superfamily (MFS), similar to others e.g. AC22_STRCO|P46105 probable actinorhodin transporter from Streptomyces coelicolor (578 aa), FASTA scores: opt: 442,E(): 4.9e-21, (28.5% identity in 466 aa overlap); etc. Contains PS00216 Sugar transport proteins signature 1. Could be termed P55. Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in M. bovis BCG (see second citation). X2BI12,Q7U042 No cell wall and cell processes Rv1410c NC_002945.3 Mycobrowser_v2 CDS 1584079 1584789 . - 0 Mb1446c lprG conserved lipoprotein lprg Mb1446c, lprG, len: 236 aa. Equivalent to Rv1411c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). Probable lprG (alternate gene name: P27), conserved lipoprotein, similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|MTCY50.12 (35.1% identity in 245 aa overlap); Rv1368, Rv2945c. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in M. bovis BCG (see second citation). X2BHT9,P0A5I9 No NC_002945.3 Mycobrowser_v2 CDS 1584874 1585479 . + 0 Mb1447 ribC PROBABLE RIBOFLAVIN SYNTHASE ALPHA CHAIN RIBC (RIBE) Mb1447, ribC, len: 201 aa. Equivalent to Rv1412,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Probable ribC (ribE),Riboflavin synthase alpha chain (EC 2.5.1.9), strong similarity to others e.g. RISA_ACTPL|P50854 (215 aa),FASTA scores: opt: 586, E(): 1.8e-33, (50.8% identity in 197 aa overlap). Contains 2 x PS00693 Riboflavin synthase alpha chain family signature. X2BI92,P65328 No intermediary metabolism and respiration Rv1412 NC_002945.3 Mycobrowser_v2 CDS 1585693 1586208 . + 0 Mb1448 CONSERVED HYPOTHETICAL PROTEIN Mb1448, -, len: 171 aa. Equivalent to Rv1413, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Conserved hypothetical protein, similar to part of AB010956|AB010956_1 metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA scores: opt: 187, E(): 0.00026, (29.0% identity in 162 aa overlap). X2BHV2 No conserved hypotheticals Rv1413 NC_002945.3 Mycobrowser_v2 CDS 1932756 1932983 . - 0 Mb1750c vapb12 possible antitoxin vapb12 Mb1750c, -, len: 75 aa. Equivalent to Rv1721c, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Conserved hypothetical protein, similar to Rv0300|MTCY63.05|O07227 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (73 aa). Start changed since original submission. Q7TZQ3 No virulence, detoxification, adaptation Rv1721c NC_002945.3 Mycobrowser_v2 CDS 1586198 1586599 . + 0 Mb1449 CONSERVED HYPOTHETICAL PROTEIN Mb1449, -, len: 133 aa. Equivalent to Rv1414, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 133 aa overlap). Conserved hypothetical protein, similar to C-terminal part of AB010956|AB010956_1 novel metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA scores: opt: 163, E(): 0.00063, (32.1% identity in 112 aa overlap). Rv1413 is similar to N-terminal part of same enzyme suggesting possible frameshift. Sequence has been checked and no errors found,it is identical in Mycobacterium tuberculosis CDC1551. X2BHJ9 No conserved hypotheticals Rv1414 NC_002945.3 Mycobrowser_v2 CDS 1586704 1587981 . + 0 Mb1450 ribA2 PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) Mb1450, ribA2, len: 425 aa. Equivalent to Rv1415,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 425 aa overlap). Probable ribA2,Riboflavin biosynthesis protein (EC 3.5.4.25), similar to many e.g. GCH2_BACSU|P17620 from Bacillus subtilis (398 aa), FASTA scores: opt: 1388, E(): 0, (55.4% identity in 399 aa overlap). Also similar to second Mycobacterium tuberculosis gtp cyclohydrolase Rv1940|ribA1 (353 aa). IN THE N-TERMINAL SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II FAMILY. X2BI18,P0A5V1 No NC_002945.3 Mycobrowser_v2 CDS 1587996 1588460 . + 0 Mb1451 ribH PROBABLE RIBOFLAVIN SYNTHASE BETA CHAIN RIBH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (Lumazine synthase) Mb1451, ribH, len: 154 aa. Equivalent to Rv1416,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Probable ribH,riboflavin synthase beta chain (EC 2.5.1.9), similar to many e.g. RISB_ECOLI|P25540 Escherichia coli (156 aa),FASTA scores: opt: 330, E(): 1.8e-15, (44.1% identity in 145 aa overlap). Note alternative GTG start possible overlapping the stop codon of Rv1415|MTCY21B4.33. BELONGS TO THE DMRL SYNTHASE FAMILY. X2BHU4,P66035 No intermediary metabolism and respiration Rv1416 NC_002945.3 Mycobrowser_v2 CDS 1588457 1588921 . + 0 Mb1452 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb1452, -, len: 154 aa. Equivalent to Rv1417, len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212,E(): 4.4e-07, (32.4% identity in 136 aa overlap). X2BI99,P64848 No cell wall and cell processes Rv1417 NC_002945.3 Mycobrowser_v2 CDS 1588946 1589632 . + 0 Mb1453 lprH PROBABLE LIPOPROTEIN LPRH Mb1453, lprH, len: 228 aa. Equivalent to Rv1418,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Probable lprH,lipoprotein. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). X2BHV9,P65317 No cell wall and cell processes Rv1418 NC_002945.3 Mycobrowser_v2 CDS 1590349 1592289 . + 0 Mb1455 uvrC probable excinuclease abc (subunit c-nuclease) uvrc Mb1455, uvrC, len: 646 aa. Equivalent to Rv1420,len: 646 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 646 aa overlap). Probable uvrC,excinuclease ABC subunit C, similar to many e.g. UVRC_PSEFL|P32966 Pseudomonas fluorescens (607 aa), fasta scores: opt: 738, E(): 8.4e-39, (36.6% identity in 629 aa overlap). BELONGS TO THE UVRC FAMILY. X2BI25,P67427 No information pathways Rv1420 NC_002945.3 Mycobrowser_v2 CDS 1592286 1593191 . + 0 Mb1456 conserved protein Mb1456, -, len: 301 aa. Equivalent to Rv1421, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins e.g. YHBJ_ECOLI|P33995 hypothetical 32.5 kd protein from Escherichia coli (284 aa), FASTA scores: opt: 648, E(): 6.3e-36, (38.7% identity in 282aa overlap). X2BHV1,P67107 No conserved hypotheticals Rv1421 NC_002945.3 Mycobrowser_v2 CDS 1593188 1594216 . + 0 Mb1457 CONSERVED HYPOTHETICAL PROTEIN Mb1457, -, len: 342 aa. Equivalent to Rv1422, len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 342 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins e.g. YAMB_THETU|P38541 Thermoanaerobacterium thermosulfurigenes (323 aa), FASTA scores: opt: 519, E(): 1.6e-25, (33.1% identity in 320 aa overlap); and AF106003|AF106003_3 Streptomyces coelicolor (363 aa), FASTA scores: opt: 1047,E(): 0, (54.5% identity in 308 aa overlap). Q7U041 No conserved hypotheticals Rv1422 NC_002945.3 Mycobrowser_v2 CDS 1594213 1595190 . + 0 Mb1458 whiA PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIA Mb1458, whiA, len: 325 aa. Equivalent to Rv1423,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 325 aa overlap). Putative whiA,transcriptional regulator, probably equivalent to AL035591|SCC54.10 whiA protein from Streptomyces coelicolor (328 aa), FASTA scores: opt: 1505, E(): 0,(70.4% identity in 324 aa overlap). Also some similarity to O06975|YVCL hypothetical protein from Bacillus subtilis (316 aa), FASTA scores: E(): 1.8e-0 8, (25.7% identity in 304 aa overlap). X2BHW9,Q7U040 No regulatory proteins Rv1423 NC_002945.3 Mycobrowser_v2 CDS 1595200 1595961 . - 0 Mb1459c POSSIBLE MEMBRANE PROTEIN Mb1459c, -, len: 253 aa. Equivalent to Rv1424c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 253 aa overlap). Possible membrane protein, contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. X2BHK9 No cell wall and cell processes Rv1424c NC_002945.3 Mycobrowser_v2 CDS 1595965 1597344 . + 0 Mb1460 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb1460, -, len: 459 aa. Equivalent to Rv1425, len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 459 aa overlap). Conserved hypothetical protein, similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv3740c, Rv3734c, Rv1760, etc. Q7U039 No lipid metabolism Rv1425 NC_002945.3 Mycobrowser_v2 CDS 1597366 1598628 . - 0 Mb1461c lipO PROBABLE ESTERASE LIPO Mb1461c, lipO, len: 420 aa. Equivalent to Rv1426c,len: 420 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 420 aa overlap). Possible Lipo, esterase (EC 3.1.-.-), similar to several Mycobacterium tuberculosis hypothetical lipases and esterases e.g. Rv1399c, Rv2284, etc. Also similar in central region to AAAD_HUMAN|P22760 human arylacetamide deacetylase (398 aa), FASTA scores: opt:210, E(): 7.6e-07, (29.3% identity in 191 aa overlap). Q7U038 No NC_002945.3 Mycobrowser_v2 CDS 1598628 1600235 . - 0 Mb1462c fadD12 POSSIBLE LONG-CHAIN-FATTY-ACID--COA LIGASE FADD12 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb1462c, fadD12, len: 535 aa. Equivalent to Rv1427c, len: 535 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 535 aa overlap). Possible fadD12, long-chain-fatty-acid-CoA synthetase (EC 6.2.1.-),similar to many e.g. NP_302632.1|NC_002677 acyl-CoA synthase from Mycobacterium leprae (548 aa); AAD01929.2|AF031419 putative long-chain-fatty-acid--CoA ligase from Pseudomonas putida (565 aa); NP_419782.1|NC_002696 putative long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (530 aa); PC60_YEAST|P38137 yeast peroxisomal-coenzyme A synthetase (543 aa), FASTA scores: opt: 507, E(): 2.9e-25, (30.4% identity in 365 aa overlap). Also similar to many M. tuberculosis proteins e.g. MTCY06A4.14 (44.8% identity in 525 aa overlap). Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U037 No lipid metabolism Rv1427c NC_002945.3 Mycobrowser_v2 CDS 1687153 1687551 . + 0 Mb1537 HYPOTHETICAL PROTEIN Mb1537, -, len: 132 aa. Equivalent to Rv1499, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 132 aa overlap). Hypothetical unknown protein, was initially longer but has been shortened owing to overlap with Rv1498A. Q7TZY8 No conserved hypotheticals Rv1499 NC_002945.3 Mycobrowser_v2 CDS 1601185 1602453 . + 0 Mb1464 conserved protein Mb1464, -, len: 422 aa. Equivalent to Rv1429, len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 422 aa overlap). Conserved hypothetical protein, some similarity to transcriptional regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate diacid regulator from Escherichia coli (391 aa), FASTA scores: opt: 210, E(): 3e-06, (27.7% identity in 296 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2370c, Rv1194c, Rv1453, Rv2242, and Rv1186c. Q7U035 No conserved hypotheticals Rv1429 NC_002945.3 Mycobrowser_v2 CDS 1602693 1604279 . + 0 Mb1465 PE16 pe family protein pe16 Mb1465, PE16, len: 528 aa. Equivalent to Rv1430,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 528 aa overlap). Member of the M. tuberculosis PE family of proteins e.g. Y0D4_MYCTU|Q50594 (55.9% identity in 127 aa overlap). The C-terminus shows similarity to Q49633|LEPB1170_F3_112 hypothetical Mycobacterium leprae protein (391 aa), FASTA scores: opt: 342, E(): 1.2e-13, (29.8% identity in 292 aa overlap). Possible TMhelix aa 500-522. Q7U034 No PE/PPE Rv1430 NC_002945.3 Mycobrowser_v2 CDS 1604390 1606159 . + 0 Mb1466 CONSERVED MEMBRANE PROTEIN Mb1466, -, len: 589 aa. Equivalent to Rv1431, len: 589 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 589 aa overlap). Conserved membrane protein, shows strong similarity to another M. tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2% identity in 585 aa overlap). Q7U033 No cell wall and cell processes Rv1431 NC_002945.3 Mycobrowser_v2 CDS 1606156 1607577 . + 0 Mb1467 PROBABLE DEHYDROGENASE Mb1467, -, len: 473 aa. Equivalent to Rv1432, len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 473 aa overlap). Probable dehydrogenase (EC 1.-.-.-), shows strong simlarity to P49_STRLI|P06108 p49 protein from Streptomyces lividans (469 aa), FASTA scores: opt: 1362, E(): 0, (44.9% identity in 474 aa overlap); and weak simlarity to other dehydrogenases. Q7U032 No intermediary metabolism and respiration Rv1432 NC_002945.3 Mycobrowser_v2 CDS 1607741 1608556 . + 0 Mb1468 POSSIBLE CONSERVED EXPORTED PROTEIN Mb1468, -, len: 271 aa. Equivalent to Rv1433, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 271 aa overlap). Possible exported protein with N-terminal signal sequence, highly similar to Q49706 hypothetical protein from Mycobacterium leprae (271 aa), FASTA scores: opt: 1341, E(): 0, (68.3% identity in 271 aa overlap). Also shows similarity to Mycobacterium tuberculosis lipoprotein Rv2518c|MTV009.03c lppS (408 aa) (40.0% identity in 230 aa overlap); and others e.g. Rv0116c, Rv0192, Rv2518c, Rv0483. Q7U031 No cell wall and cell processes Rv1433 NC_002945.3 Mycobrowser_v2 CDS 1608563 1608700 . + 0 Mb1469 HYPOTHETICAL PROTEIN Mb1469, -, len: 45 aa. Equivalent to Rv1434, len: 45 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 45 aa overlap). Hypothetical unknown protein. Q7U030 No conserved hypotheticals Rv1434 NC_002945.3 Mycobrowser_v2 CDS 1608649 1609278 . - 0 Mb1470c Probable conserved Proline, Glycine, Valine-rich secreted protein Mb1470c, -, len: 209 aa. Highly similar to Rv1435c,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(96.2% identity in 209 aa overlap). Probable conserved Pro-, Gly-, Val-rich secreted protein (see citation below) with a N-terminal signal sequence. Similar at C-terminus to AF017099|AF017099_1 Mycobacterium tuberculosis pGB1 (87 aa), FASTA scores: opt: 550, E(): 2.3e-17, (97.7% identity in 86 aa overlap). Shows some similarity to N-terminus of CPN_DROME|Q02910 calphotin. drosophila melanogaster (865 aa), FASTA scores: opt: 266, E(): 2.5e-05, (37.2% identity in 191 aa overlap). Contains at least five 7 aa imperfect repeats. Also shows similarity to other Mycobacterium tuberculosis proteins e.g. MTCI237.20c (34.7% identity in 193 aa overlap), MTCI65.25c (36.9% identity in 160 aa overlap) and MTCI65.24c (34.2% identity in 196 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa). Q7U029 No NC_002945.3 Mycobrowser_v2 CDS 1638239 1639171 . - 0 Mb1491c PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER Mb1491c, -, len: 310 aa. Equivalent to Rv1456c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 310 aa overlap). Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.34 from Mycobacterium leprae (311 aa),FASTA scores: opt: 1607, E(): 0, (83.3% identity in 300 aa overlap). Q7U016 No cell wall and cell processes Rv1456c NC_002945.3 Mycobrowser_v2 CDS 1655726 1656100 . + 0 Mb1505 trxA PROBABLE THIOREDOXIN TRXA Mb1505, trxA, len: 124 aa. Equivalent to Rv1470,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Probable trxA,thioredoxin (EC 1.-.-.-), similar to many e.g. P12243|THI1_SYNP7 THIOREDOXIN 1 from Synechococcus sp. (106 aa), FASTA scores: opt: 201, E(): 9.2e-08, (35.4% identity in 99 aa overlap); etc. Highly similar to downstream ORF Rv1471|trxB1 probable thioredoxin from M. tuberculosis (123 aa), FASTA scores: opt: 402, E(): 0,(54.4% identity in 114 aa overlap). Warning: note that Rv3914|MT4033|MTV028.05|trxC can be alternatively named trxA. Q7U006 No intermediary metabolism and respiration Rv1470 NC_002945.3 Mycobrowser_v2 CDS 1609635 1610654 . + 0 Mb1471 gap PROBABLE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GAP (GAPDH) Mb1471, gap, len: 339 aa. Equivalent to Rv1436,len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 339 aa overlap). Probable gap,Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12),highly similar to many e.g. G3P_MYCLE|P46713 Mycobacterium leprae (339 aa), FASTA scores: opt: 1933, E():0, (89.1% identity in 339 aa overlap). Contains PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. BELONGS TO THE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FAMILY. X2BHX4,P64179 No intermediary metabolism and respiration Rv1436 NC_002945.3 Mycobrowser_v2 CDS 1610657 1611895 . + 0 Mb1472 pgk PROBABLE PHOSPHOGLYCERATE KINASE PGK Mb1472, pgk, len: 412 aa. Equivalent to Rv1437,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 412 aa overlap). Probable pgk,Phosphoglycerate kinase (EC 2.7.2.3), highly similar to many e.g. PGK_MYCLE|P46712 Mycobacterium leprae (416 aa),FASTA scores: opt: 2153, E(): 0, (80.4% identity in 414 aa overlap). Contains PS00111 Phosphoglycerate kinase signature. BELONGS TO THE PHOSPHOGLYCERATE KINASE FAMILY. X2BIC0,P65701 No intermediary metabolism and respiration Rv1437 NC_002945.3 Mycobrowser_v2 CDS 1611892 1612677 . + 0 Mb1473 tpi PROBABLE TRIOSEPHOSPHATE ISOMERASE TPI (TIM) Mb1473, tpi, len: 261 aa. Equivalent to Rv1438,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Probable tpi (tpiA),Triosephosphate isomerase (EC 5.3.1.1), highly similar to many e.g. TPIS_MYCLE|P46711 Mycobacterium leprae (261 aa),FASTA scores: opt: 1456, E(): 0, (83.9% identity in 261 aa overlap). Contains PS00171 Triosephosphate isomerase active site. BELONGS TO THE TRIOSEPHOSPHATE ISOMERASE FAMILY. X2BHY6,P66941 No intermediary metabolism and respiration Rv1438 NC_002945.3 Mycobrowser_v2 CDS 1614165 1614398 . + 0 Mb1475 secG probable protein-export membrane protein (translocase subunit) secg Mb1475, secG, len: 77 aa. Equivalent to Rv1440,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 77 aa overlap). Probable protein-export membrane protein secG, similar to many e.g. P38388|SECG_MYCLE PROBABLE PROTEIN-EXPORT MEMBRANE (77 aa), FASTA scores: opt: 450, E(): 6.7e-24, (96.1% identity in 77 aa overlap). Start changed since original submission (-40 aa). PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c,SECE|Rv0638, SECF|Rv2586c, SECG AND SECY|Rv0732. X2BI51,P66792 No cell wall and cell processes Rv1440 NC_002945.3 Mycobrowser_v2 CDS 1694746 1695015 . + 0 Mb1546 CONSERVED HYPOTHETICAL PROTEIN Mb1546, -, len: 89 aa. Equivalent to Rv1519, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 89 aa overlap). Conserved hypothetical protein, high similarity to C-terminus of Q50723|MTCY78.26|Rv3402c (412 aa) (58.1% identity in 74 aa overlap). X2BI40,P64862 No conserved hypotheticals Rv1519 NC_002945.3 Mycobrowser_v2 CDS 1614537 1616012 . - 0 Mb1476c PE_PGRS26 pe-pgrs family protein pe_pgrs26 Mb1476c, PE_PGRS26, len: 491 aa. Equivalent to Rv1441c, len: 491 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 491 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kd protein (498 aa), fasta scores: opt: 1625, E(): 0, (55.2% identity in 518 aa overlap). Q7U027 No NC_002945.3 Mycobrowser_v2 CDS 1616119 1618419 . + 0 Mb1477 bisC PROBABLE BIOTIN SULFOXIDE REDUCTASE BISC (BDS reductase) (BSO reductase) Mb1477, bisC, len: 766 aa. Equivalent to Rv1442,len: 766 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 766 aa overlap). Probable bisC, Biotin sulfoxide reductase (EC 1.-.-.-), similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa), FASTA scores: opt: 1271, E():0,(40.2% identity in 744 aa overlap). Q7U026 No intermediary metabolism and respiration Rv1442 NC_002945.3 Mycobrowser_v2 CDS 1618535 1619020 . - 0 Mb1478c unknown protein Mb1478c, -, len: 161 aa. Equivalent to Rv1443c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 161 aa overlap). Hypothetical unknown protein. Q7U025 No conserved hypotheticals Rv1443c NC_002945.3 Mycobrowser_v2 CDS 1620061 1620804 . - 0 Mb1480c devB PROBABLE 6-PHOSPHOGLUCONOLACTONASE DEVB (6PGL) Mb1480c, devB, len: 247 aa. Equivalent to Rv1445c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 247 aa overlap). Possible devB (PGL),6-phosphogluconolactonase (EC 3.1.1.31), belongs to a different family to the upstream gene zwf2. Similar to e.g. DEVB_ANASP|P46016 putative glucose-6-phosphate 1-dehydrogenase (239 aa), FASTA scores: opt: 439, E(): 2.6e-20, (34.0% identity in 247 aa overlap). BELONGS TO THE GLUCOSAMINE/GALACTOSAMINE-6-PHOSPHATE ISOMERASE FAMILY. 6-PHOSPHOGLUCONOLACTONASE SUBFAMILY. X2BI57,P63339 No NC_002945.3 Mycobrowser_v2 CDS 1620801 1621712 . - 0 Mb1481c opcA PUTATIVE OXPP CYCLE PROTEIN OPCA Mb1481c, opcA, len: 303 aa. Equivalent to Rv1446c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Putative opcA, OxPP cycle protein. Highly similar to S72774 B1496_F1_30 protein from Mycobacterium leprae (265 aa), FASTA scores: opt: 1056, E(): 0, (70.3% identity in 239 aa overlap). Also similar to OPCA_NOSS2|P48971 putative oxppcycle protein opca from Nostoc punctiforme (465 aa), fasta scores: opt: 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). AIDS IN G6PD ACTIVITY. Q7U023 No NC_002945.3 Mycobrowser_v2 CDS 1621765 1623309 . - 0 Mb1482c zwf2 PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD) Mb1482c, zwf2, len: 514 aa. Equivalent to Rv1447c,len: 514 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 514 aa overlap). Probable zwf2 (ZWF),Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), highly similar to many e.g. G6PD_SYNY3|P73411 Synechocystis sp. (509 aa), FASTA scores: opt: 1578, E(): 0, (46.8% identity in 509 aa overlap). Also similar to Mycobacterium tuberculosis Rv1121, zwf glucose-6-phosphate 1-dehydrogenase. Contains PS00069 Glucose-6-phosphate dehydrogenase active site. M. tuberculosis has two genes for ZWF. This one looks like a classical ZWF. BELONGS TO THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY. X2BID3,P0A585 No NC_002945.3 Mycobrowser_v2 CDS 1623306 1624427 . - 0 Mb1483c tal PROBABLE TRANSALDOLASE TAL Mb1483c, tal, len: 373 aa. Equivalent to Rv1448c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 373 aa overlap). Probable tal,Transaldolase (EC 2.2.1.2), highly similar to many e.g. TAL_MYCLE|P55193 transaldolase from Mycobacterium leprae (375 aa), FASTA scores: opt: 1891, E(): 0, (78.6% identity in 370 aa overlap). BELONGS TO THE TRANSALDOLASE FAMILY. X2BI00,P59955 No NC_002945.3 Mycobrowser_v2 CDS 1624444 1626546 . - 0 Mb1484c tkt transketolase tkt (tk) Mb1484c, tkt, len: 700 aa. Equivalent to Rv1449c,len: 700 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 700 aa overlap). Probable tkt,Transketolase (EC 2.2.1.1). Highly similar to several e.g. TKT_MYCLE|P46708 transketolase (tk) from Mycobacterium leprae (699 aa), FASTA scores: opt: 4216, E(): 0, (89.1% identity in 700 aa overlap). Start site chosen by homology. Contains PS00801 Transketolase signature 1. BELONGS TO THE TRANSKETOLASE FAMILY. X2BHN3,P59956 No NC_002945.3 Mycobrowser_v2 CDS 1626985 1631211 . - 0 Mb1485c PE_PGRS27 pe-pgrs family protein pe_pgrs27 Mb1485c, PE_PGRS27, len: 1408 aa. Similar to Rv1450c, len: 1329 aa, from Mycobacterium tuberculosis strain H37Rv, (92.1% identity in 1417 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), fasta scores: opt: 2112, E(): 0, (56.5% identity in 630 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 27 bp, 207 bp and 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa). Q7U022 No NC_002945.3 Mycobrowser_v2 CDS 1990514 1990873 . + 0 Mb1796 conserved protein Mb1796, -, len: 119 aa. Equivalent to Rv1767, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Conserved hypothetical protein, similar to Q57498|YA53_HAEIN HYPOTHETICAL PROTEIN HI1053 from Haemophilus influenzae (113 aa), FASTA scores: opt: 233, E(): 6.4e-10, (40.0% identity in 90 aa overlap). Q7TZL1 No conserved hypotheticals Rv1767 NC_002945.3 Mycobrowser_v2 CDS 1944640 1945188 . - 0 Mb1761c conserved protein Mb1761c, -, len: 182 aa. Equivalent to Rv1732c,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 182 aa overlap). Conserved hypothetical protein, highly similar to hypothetical proteins from several organisms e.g. P73178|SLL1289|D90904 from Synechocystis (194 aa), FASTA scores: opt: 663, E(): 0,(53.1% identity in 179 aa overlap); etc. Q7TZP2 No conserved hypotheticals Rv1732c NC_002945.3 Mycobrowser_v2 CDS 1631613 1632539 . + 0 Mb1486 ctaB PROBABLE CYTOCHROME C OXIDASE ASSEMBLY FACTOR CTAB Mb1486, ctaB, len: 308 aa. Equivalent to Rv1451,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 308 aa overlap). Probable ctaB,cytochrome C oxidase assembly factor, and integral membrane protein. Highly similar to several Mycobacterium leprae proteins e.g. Q49685 CYOE cytochrome O ubiquinol oxidase assembly factor (300 aa), FASTA scores: opt: 1636,E(): 0, (82.7% identity in 307 aa overlap); NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa); NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa). X2BI03,Q7U021 No intermediary metabolism and respiration Rv1451 NC_002945.3 Mycobrowser_v2 CDS 1632588 1634975 . - 0 Mb1487c PE_PGRS28 pe-pgrs family protein pe_pgrs28 Mb1487c, PE_PGRS28, len: 795 aa. Highly similar to Rv1452c, len: 741 aa, from Mycobacterium tuberculosis strain H37Rv, (89.1% identity in 795 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), fasta scores: opt: 2090, E(): 0, (56.3% identity in 641 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,substitutions of 3 bp to 144 bp, 40 bp to 49 bp, 31 bp to 31 bp, 4 bp to 4 bp (gggc-ttgg), 12 bp to 12 bp, 11 bp to 11 bp, 60 bp to 63 bp, 13 bp to 13 bp and 2 bp to 2 bp (tt-cc), and a 9 bp insertion (*-cccgccggc), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (795 aa versus 741 aa). Q7U020 No NC_002945.3 Mycobrowser_v2 CDS 1727791 1728384 . - 0 Mb1568c lprI Possible lipoprotein lprI Mb1568c, lprI, len: 197 aa. Equivalent to Rv1541c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 197 aa overlap). Possible lipoprotein lprI, contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS0013). X2BI97,P65319 No NC_002945.3 Mycobrowser_v2 CDS 1635127 1636392 . + 0 Mb1488 POSSIBLE TRANSCRIPTIONAL ACTIVATOR PROTEIN Mb1488, -, len: 421 aa. Equivalent to Rv1453, len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 421 aa overlap). Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa). Q7U019 No regulatory proteins Rv1453 NC_002945.3 Mycobrowser_v2 CDS 1636420 1637406 . - 0 Mb1489c qor PROBABLE QUINONE REDUCTASE QOR (NADPH:quinone reductase) (Zeta-crystallin homolog protein) Mb1489c, qor, len: 328 aa. Equivalent to Rv1454c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 328 aa overlap). Probable qor, quinone oxidoreductase (EC 1.6.5.5), simiar to U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter capsulatus (323 aa), FASTA scores: opt: 849, E(): 0, (44.7% identity in 329 aa overlap). Also similar to MTCY180.06 Hypothetical protein from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 430, E(): 2e-14, (32.3% identity in 350 aa overlap). Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. Q7U018 No NC_002945.3 Mycobrowser_v2 CDS 1637426 1638289 . + 0 Mb1490 conserved protein Mb1490, -, len: 287 aa. Equivalent to Rv1455, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 287 aa overlap). Conserved hypothetical protein, some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08,(51.3% identity in 78 aa overlap). Q7U017 No conserved hypotheticals Rv1455 NC_002945.3 Mycobrowser_v2 CDS 1639283 1640068 . - 0 Mb1492c PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER Mb1492c, -, len: 261 aa. Equivalent to Rv1457c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.32 from Mycobacterium leprae (265 aa),FASTA scores: opt: 1415, E(): 0, (83.1% identity in 260 aa overlap). Q7U015 No cell wall and cell processes Rv1457c NC_002945.3 Mycobrowser_v2 CDS 1640065 1641006 . - 0 Mb1493c PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER Mb1493c, -, len: 313 aa. Equivalent to Rv1458c,len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 313 aa overlap). Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.31 from Mycobacterium leprae (315 aa), FASTA scores: opt: 1812,E(): 0, (88.0% identity in 308 aa overlap). Similar to AF027770|AF027770_7 ABC-type transporter in FxbA region in Mycobacterium smegmatis (284 aa), FASTA scores: opt: 1412,E(): 0, (85.1% identity in 248 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7U014 No cell wall and cell processes Rv1458c NC_002945.3 Mycobrowser_v2 CDS 1641109 1642884 . - 0 Mb1494c POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb1494c, -, len: 591 aa. Equivalent to Rv1459c,len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 591 aa overlap). Possible conserved integral membrane protein, equivalent to MLCL536.30|Z99125 hypothetical protein from Mycobacterium leprae (593 aa),FASTA scores: opt: 1670, E(): 0, (78.6% identity in 585 aa overlap). Also similar to Mycobacterium tuberculosis protein Rv2174|MTV021.07 (33.1% identity in 523 aa overlap). Q7U013 No cell wall and cell processes Rv1459c NC_002945.3 Mycobrowser_v2 CDS 1642932 1643738 . + 0 Mb1495 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1495, -, len: 268 aa. Equivalent to Rv1460, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 268 aa overlap). Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 -89. Start changed since original submission. Q7U012 No regulatory proteins Rv1460 NC_002945.3 Mycobrowser_v2 CDS 1643735 1646275 . + 0 Mb1496 conserved protein Mb1496, -, len: 846 aa. Equivalent to Rv1461, len: 846 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 846 aa overlap). Conserved hypothetical protein. Equivalent of spliced protein from Mycobacterium leprae MLCL536.28c len: 869. Residues 1-253 represent N-extein, and 613-846 the C-extein. The intein present from residues 254 - 612 is different in sequence and site of the insertion from the one present in MLCL536.28c. FASTA scores: Z99125|MLCL536_23 Mycobacterium leprae cosmid L536 (869 aa), opt: 1498 E(): 0, (54.1% identity in 917 aa overlap). The mature protein is similar to Z99120|BSUB0017_150 hypothetical Bacillus subtilis protein (465 aa), FASTA scores: opt:1053, E(): 0, (34.8% identity in 821 aa overlap). The intein shows some similarity to inteins from U67548|MJU67548_6 Methanococcus jannaschii (895 aa), FASTA scores: opt: 181, E(): 0.00023, (25.2% identity in 274 aa overlap). X2BI10,P67126 No conserved hypotheticals Rv1461 NC_002945.3 Mycobrowser_v2 CDS 1646272 1647465 . + 0 Mb1497 CONSERVED HYPOTHETICAL PROTEIN Mb1497, -, len: 397 aa. Equivalent to Rv1462, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Conserved hypothetical protein. Equivalent to MLCL536.27c|Z99125 hypothetical protein from Mycobacterium leprae (392 aa), FASTA scores: opt: 2059, E(): 0, (80.4% identity in 392 aa overlap). Also similar to nearby Mycobacterium tuberculosis hypothetical protein Rv1461. X2BIH2,P59973 No conserved hypotheticals Rv1462 NC_002945.3 Mycobrowser_v2 CDS 1647462 1648262 . + 0 Mb1498 PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER Mb1498, -, len: 266 aa. Equivalent to Rv1463, len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 266 aa overlap). Probable conserved ATP-binding protein ABC transporter, equivalent to Z99125|MLCL536.26c putative ABC transporter ATP-binding protein from Mycobacterium leprae (260 aa), FASTA scores: opt: 1444, E(): 0, (86.0% identity in 267 aa overlap). Very similar to U38804|PPU38804_55 ATP-DEPENDENT TRANSPORTER YCF16 from PORPHYRA PURPUREA chloroplast (251 aa), FASTA scores: opt: 822, E(): 0, (52.4% identity in 248 aa overlap); and similar to others. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7U011 No cell wall and cell processes Rv1463 NC_002945.3 Mycobrowser_v2 CDS 1648264 1649517 . + 0 Mb1499 csd PROBABLE CYSTEINE DESULFURASE CSD Mb1499, csd, len: 417 aa. Equivalent to Rv1464,len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 417 aa overlap). Probable csd, cysteine desulfurase (EC 4.4.1.- ). Equivalent to Q49690|MLCL536.25C cysteine desulfurase from Mycobacterium leprae (418 aa), FASTA scores: opt: 2333, E(): 0, (85.4% identity in 417 aa overlap); and similar to cysteine desulfurase from other organisms. Also similar to M. tuberculosis proteins Rv3025c|ISCS and Rv3778c. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. CSD SUBFAMILY. X2BHR0,P63517 No intermediary metabolism and respiration Rv1464 NC_002945.3 Mycobrowser_v2 CDS 1649514 1650002 . + 0 Mb1500 POSSIBLE NITROGEN FIXATION RELATED PROTEIN Mb1500, -, len: 162 aa. Equivalent to Rv1465, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 162 aa overlap). Possible nitrogen fixation related protein. Equivalent to Z99125|MLCL536.24c nitrogen fixation protein NIFU from Mycobacterium leprae (165 aa), FASTA scores: opt: 870, E(): 0, (81.8% identity in 165 aa overlap). Also similar to O32163|Z99120|NIFU_BACSU NifU-like protein from Bacillus subtilis (147 aa), FASTA scores: opt: 354, E(): 4.1e-17,(38.3% identity in 141 aa overlap) and to AL096839|SCC22.02 hypothetical protein from Streptomyces coelicolor (156 aa), FASTA scores: opt: 569, E(): 1.2e-31,(56.3% identity in 158 aa overlap). Q7U010 No intermediary metabolism and respiration Rv1465 NC_002945.3 Mycobrowser_v2 CDS 1649977 1650324 . + 0 Mb1501 conserved protein Mb1501, -, len: 115 aa. Equivalent to Rv1466, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Conserved hypothetical protein. Equivalent to Z99125|MLCL536.23c hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 648, E(): 0, (81.7% identity in 115 aa overlap). Similar to ORF's downstream of sigma factors in Streptococcus mutans and Streptococcus pneumoniae e.g. O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa). Alternative TTG start possible at 13757 then avoids overlap with MTV007.12. Q7U009 No conserved hypotheticals Rv1466 NC_002945.3 Mycobrowser_v2 CDS 1650419 1652248 . - 0 Mb1502c fadE15 PROBABLE ACYL-COA DEHYDROGENASE FADE15 Mb1502c, fadE15, len: 609 aa. Equivalent to Rv1467c, len: 609 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 609 aa overlap). Probable fadE15, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to NP_302639.1|NC_002677 acyl-CoA dehydrogenase from Mycobacterium leprae (611 aa). Also highly similar to many e.g. T36481 probable acyl-CoA dehydrogenase (fragment) from Streptomyces coelicolor (491 aa) (has its N-terminus very shorter); NP_384640.1|NC_003047 PUTATIVE ACYL-COA DEHYDROGENASE PROTEIN from Sinorhizobium meliloti (598 aa); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain specific) from Megasphaera elsdenii (383 aa),FASTA scores: E(): 2e-12, (25.4% identity in 410 aa overlap); etc. Also highly similar to fadE5|Rv0244c|MTV034.10c ACYL-COA DEHYDROGENASE from M. tuberculosis (611 aa); and similar to other proteins from Mycobacterium tuberculosis. Q7U008 No lipid metabolism Rv1467c NC_002945.3 Mycobrowser_v2 CDS 1652355 1653467 . - 0 Mb1503c PE_PGRS29 pe-pgrs family protein pe_pgrs29 Mb1503c, PE_PGRS29, len: 370 aa. Equivalent to Rv1468c, len: 370 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 370 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Q7U007 No NC_002945.3 Mycobrowser_v2 CDS 1653709 1655682 . + 0 Mb1504 ctpD PROBABLE CATION TRANSPORTER P-TYPE ATPASE D CTPD Mb1504, ctpD, len: 657 aa. Equivalent to Rv1469,len: 657 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 657 aa overlap). Probable ctpD,cation-transporting P-type ATPase D (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. T35947 probable cation-transporting ATPase from Streptomyces coelicolor (638 aa); NP_442633.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (642 aa), FASTA scores: opt: 1438, E(): 0, (41.9% identity in 592 aa overlap); NP_389268.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (637 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3743c|MTV025.091c|CTPJ (660 aa). Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. X2BHR4,P63686 No cell wall and cell processes Rv1469 NC_002945.3 Mycobrowser_v2 CDS 2142705 2143175 . - 0 Mb1941c conserved protein Mb1941c, -, len: 156 aa. Equivalent to Rv1906c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, possibly exported protein,equivalent to Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa), FASTA scores: opt: 637, E(): 2.6e-28, (63.2% identity in 155 aa overlap). Also similar to M. tuberculosis hypothetical exported protein, Rv1352. Q7TZB3 No conserved hypotheticals Rv1906c NC_002945.3 Mycobrowser_v2 CDS 1718747 1719424 . + 0 Mb1561 Probable transcriptional regulator Mb1561, -, len: 225 aa. Equivalent to Rv1534, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 225 aa overlap). Probable transcriptional regulator, similar to YCDC_ECOLI|P75899 hypothetical transcriptional regulator from Escherichia coli (212 aa), FASTA scores: opt: 166, E(): 9.8e-05,(24.2% identity in 219 aa overlap). Contains PS01081 Bacterial regulatory proteins, tetR family signature and helix turn helix motif (aa 41-62). Q7VEZ1 No regulatory proteins Rv1534 NC_002945.3 Mycobrowser_v2 CDS 1656116 1656487 . + 0 Mb1506 trxB1 PROBABLE THIOREDOXIN TRXB1 Mb1506, trxB1, len: 123 aa. Equivalent to Rv1471,len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 123 aa overlap). Probable trxB1,thioredoxin (EC 1.-.-.-), similar to many bacterial thioredoxins e.g. P33636|THI2_ECOLI from Escherichia coli (139 aa), FASTA scores: opt: 290, E(): 1.8e-13, (44.3% identity in 97 aa overlap); etc. Highly similar to Rv1470|TrxA probable thioredoxin from Mycobacterium tuberculosis (124 aa), FASTA scores: opt: 402, E(): 1.2e-32, (54.4% identity in 114 aa overlap). Contains PS00194 Thioredoxin family active site. BELONGS TO THE THIOREDOXIN FAMILY. Note that previously known as trxB. Q7U005 No NC_002945.3 Mycobrowser_v2 CDS 1656509 1657366 . + 0 Mb1507 echA12 POSSIBLE ENOYL-CoA HYDRATASE ECHA12 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) Mb1507, echA12, len: 285 aa. Equivalent to Rv1472,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Possible echA12,enoyl-CoA hydratase (EC 4.2.1.17), highly similar to P53526|ECHH_MYCLE|NP_301896.1|NC_002677 possible enoyl-CoA hydratase/isomerase from Mycobacterium leprae (294 aa),FASTA scores: opt: 1265, E(): 0, (72.0% identity in 271 aa overlap). Also similar to others e.g. CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli strain K12 (262 aa); CAC44593.1|AL596162 putative enoyl-CoA hydratase from Streptomyces coelicolor (275 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. ECHA16|Rv2831|MTCY16B7.11c (249 aa), FASTA scores: opt: 232, E(): 1.3e-15, (33.8% identity in 204 aa overlap); etc. TBparse score is 0.916. X2BIH9,Q7U004 No NC_002945.3 Mycobrowser_v2 CDS 1657402 1659030 . + 0 Mb1508 PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER Mb1508, -, len: 542 aa. Equivalent to Rv1473, len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 542 aa overlap). Possible macrolide-transport ATP-binding protein ABC transporter (see citation below), possibly in EF-3 subfamily. Similar to many ABC-transporters e.g. D90909_48|YHES_HAEIN from Synechocystis sp. strain PCC6803 (574 aa), FASTA scores: opt: 870, E(): 0, (33.3% identity in 525 aa overlap); P44808|YHES_HAEIN from Haemophilus influenzae (638 aa),FASTA scores: opt: 706, E(): 0, (33.7% identity in 517 aa overlap); etc. Contains two PS00017 ATP/GTP-binding site motif A (P-loop), and two PS00211 ABC transporter family signatures. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7U003 No cell wall and cell processes Rv1473 NC_002945.3 Mycobrowser_v2 CDS 1659127 1659318 . + 0 Mb1509 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1509, -, len: 63 aa. Equivalent to Rv1473A, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(98.4% identity in 63 aa overlap). Possible transcriptional regulator, CDS predicted by GC plot. Similar to SCI8.24c|AL132644_24 putative transcriptional regulator from Streptomyces coelicolor (73 aa), FASTA scores: opt: 210, E(): 1.5e-08, (56.15% identity in 57 aa overlap). Q7U002 No regulatory proteins Rv1473A NC_002945.3 Mycobrowser_v2 CDS 1659387 1659950 . - 0 Mb1510c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1510c, -, len: 187 aa. Equivalent to Rv1474c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 187 aa overlap). Probable transcription regulator, equivalent to AF0021|AF002133_1 transcriptional regulator from Mycobacterium avium strain GIR10 (82 aa),FASTA scores: opt: 490, E(): 6.7e-26, (92.5% identity in 80 aa overlap). Also similar to Q59431|UIDR_ECOLI UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli (196 aa), FASTA scores: opt: 192, E(): 5.8e-06, (28.5% identity in 172 aa overlap). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Helix turn helix motif predicted at aa 33-54 (+3.40 SD). Q7U001 No regulatory proteins Rv1474c NC_002945.3 Mycobrowser_v2 CDS 1719989 1720225 . + 0 Mb1562 unknown protein Mb1562, -, len: 78 aa. Equivalent to Rv1535, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 78 aa overlap). Hypothetical unknown protein. Q7TZX4 No conserved hypotheticals Rv1535 NC_002945.3 Mycobrowser_v2 CDS 1659961 1662792 . - 0 Mb1511c acn probable iron-regulated aconitate hydratase acn (citrate hydro-lyase) (aconitase) Mb1511c, acn, len: 943 aa. Equivalent to Rv1475c,len: 943 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 943 aa overlap). Probable acn, aconitate hydratase (EC 4.2.1.3), similar to many e.g. P70920|ACON_BRAJA ACONITATE HYDRATASE from Bradyrhizobium japonicum (906 aa), FASTA scores: opt:1912, E(): 0, (54.8% identity in 958 aa overlap); closest to AF0021|AF002133_2 Mycobacterium avium strain GIR10 (961 aa), FASTA scores: opt: 5072, E(): 0, (82.8% identity in 943 aa overlap). NOTE ACONITASE HAS AN ACTIVE (4FE-4S) AND AN INACTIVE (3FE-4S) FORMS. THE ACTIVE (4FE-4S) CLUSTER IS PART OF THE CATALYTIC SITE THAT INTERCONVERTS CITRATE, CIS-ACONITASE,AND ISOCITRATE. Q7U000 No NC_002945.3 Mycobrowser_v2 CDS 1662950 1663510 . + 0 Mb1512 POSSIBLE MEMBRANE PROTEIN Mb1512, -, len: 186 aa. Equivalent to Rv1476, len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 186 aa overlap). Possible membrane protein, TMhelix 138-60. Q7TZZ9 No cell wall and cell processes Rv1476 NC_002945.3 Mycobrowser_v2 CDS 1663736 1665154 . + 0 Mb1513 ripa peptidoglycan hydrolase Mb1513, -, len: 472 aa. Equivalent to Rv1477, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 472 aa overlap). Hypothetical Invasion protein. Possibly exported protein with unusually long signal sequence. The last 277 residues are nearly identical to those of AF0060|AF006054_1 hypothetical invasion protein INV1 from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 1833, E(): 0, (98.2% identity in 277 aa overlap); also very similar to AF0021|AF002133_4 invasin 1 protein from Mycobacterium avium (273 aa), FASTA scores: opt: 1452, E(): 0, (78.1% identity in 279 aa overlap). Similar to Rv1566c|MTCY336.37|Z95586 Mycobacterium tuberculosis cosmid (230 aa), FASTA scores: opt: 528, E(): 4.4e-20, (52.0% identity in 150 aa overlap); and weakly similar to p60 proteins of Listeria spp throughout its length e.g. M80351|LISIAPB_1 Listeria monocytogenes iap-related protein (478 aa), FASTA scores: opt: 251, E(): 8e-06, (24.4% identity in 487 aa overlap). C-terminal domain highly similar to next ORF Rv1478|MTV007.25. Q7TZZ8 No virulence, detoxification, adaptation Rv1477 NC_002945.3 Mycobrowser_v2 CDS 1953643 1954308 . + 0 Mb1771 unknown protein Mb1771, -, len: 221 aa. Equivalent to the 3' end of Rv1742, len: 245 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 220 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7TZN4 No NC_002945.3 Mycobrowser_v2 CDS 1665165 1665890 . + 0 Mb1514 possible invasion protein Mb1514, -, len: 241 aa. Equivalent to Rv1478, len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 241 aa overlap). Hypothetical Invasion protein. Possibly exported protein, nearly identical to AF0060|AF006054_2 hypothetical invasion protein INV2 of M. tuberculosis (240 aa), FASTA scores: opt: 1509, E(): 0,(95.0% identity in 241 aa overlap); very similar to AF0021|AF002133_5 hypothetical invasion protein INV2 from Mycobacterium avium (244 aa), FASTA scores: opt: 1269,E():0, (78.0% identity in 246 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY336.37 and weakly similar to C-terminal segment of p60 proteins of Listeria spp.e.g. Q01836|P60_LISIN PROTEIN P60 PRECURSOR (481 aa),FASTA scores: opt: 241, E():4e-07, (37.7% identity in 122 aa overlap). Highly similar to C-terminal domain of preceeding ORF Rv1477|MTV007.24 (472 aa), FASTA scores: opt: 864, E(): 0, (60.1% identity in 213 aa overlap). Q7TZZ7 No virulence, detoxification, adaptation Rv1478 NC_002945.3 Mycobrowser_v2 CDS 1720532 1723657 . + 0 Mb1563 ileS isoleucyl-tRNA synthetase ileS Mb1563, ileS, len: 1041 aa. Equivalent to Rv1536,len: 1041 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1041 aa overlap). ileS,Isoleucyl-tRNA synthetase (EC 6.1.1.5) , similar to several e.g. SYIC_YEAST P09436 isoleucyl-tRNA synthetase (1072 aa), FASTA scores: opt: 1447, E(): 0, (37.8% identity in 1072 aa overlap); contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. X2BI93,Q7VEZ0 No NC_002945.3 Mycobrowser_v2 CDS 1666029 1667162 . + 0 Mb1515 moxR1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN MOXR1 Mb1515, moxR1, len: 377 aa. Equivalent to Rv1479,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 377 aa overlap). Probable moxR1,transcriptional regulatory protein, similar to X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi (329 aa), FASTA scores: opt: 850, E():0,(43.5% identity in 317 aa overlap); and P. denitrificans. Highly similar to MoxR homologs of Mycobacterium tuberculosis and M. avium (but these both differ at C-terminus) e.g. Rv3692, Rv3164c, and AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309 aa), FASTA scores: opt: 1181, E(): 0, (83.7% identity in 227 aa overlap). Also similar to O33173|AF006054 MoxR fragment from Mycobacterium tuberculosis (211 aa), FASTA scores: opt: 1305, E(): 0, (94.3% identity in 212 aa overlap). Note that previously known as moxR. Q7TZZ6 No NC_002945.3 Mycobrowser_v2 CDS 1667159 1668112 . + 0 Mb1516 conserved protein Mb1516, -, len: 317 aa. Equivalent to Rv1480, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 317 aa overlap). Conserved hypothetical protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 KD Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642,E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693. X2BI22 No conserved hypotheticals Rv1480 NC_002945.3 Mycobrowser_v2 CDS 1668123 1669130 . + 0 Mb1517 PROBABLE MEMBRANE PROTEIN Mb1517, -, len: 335 aa. Equivalent to Rv1481, len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 335 aa overlap). Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kd protein mav335 from M. avium (335 aa), FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317,E(): 2e-12, (26.5% identity in 340 aa overlap). X2BII7,P64856 No cell wall and cell processes Rv1481 NC_002945.3 Mycobrowser_v2 CDS 1669203 1670045 . - 0 Mb1518c CONSERVED HYPOTHETICAL PROTEIN Mb1518c, -, len: 280 aa. Equivalent to Rv1482c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to O07396|AF002133 Mycobacterium avium protein MAV346 (346 aa), FASTA scores: E(): 0,(65.2% identity in 342 aa overlap); slight similarity to GRPE_ECOLI|P09372 heat shock protein from E. coli (197 aa), FASTA scores: opt: 139, E(): 0.012, (28.3% identity in 159 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins Rv3517, Rv3555c, Rv3714c, Rv1073,etc. Start changed since first submission (-59 aa). Q7TZZ5 No conserved hypotheticals Rv1482c NC_002945.3 Mycobrowser_v2 CDS 1670186 1670929 . + 0 Mb1519 fabG1 3-oxoacyl-[acyl-carrier protein] reductase fabg1 (3-ketoacyl-acyl carrier protein reductase) (mycolic acid biosynthesis a protein) Mb1519, fabG1, len: 247 aa. Equivalent to Rv1483,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 247 aa overlap). Probable fabG1 (alternate gene name: mabA), 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100), equivalent to O07399|FABG_MYCAV 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Mycobacterium avium (255 aa); P71534|FABG_MYCSM 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Mycobacterium smegmatis (255 aa); and NP_302228.1|NC_002677 3-oxoacyl-[ACP] reductase (aka MabA) from Mycobacterium leprae (253 aa). Also highly similar to many e.g. T36779 probable 3-oxacyl-(acyl-carrier-protein) reductase from Streptomyces coelicolor (234 aa); FABG_ECOLI|P25716|NP_415611.1|NC_000913 3-oxoacyl-[acyl-carrier-protein] reductase from Escherichia coli strain K12 (244 aa), FASTA scores: opt: 664, E(): 6.8e-35, (44.4% identity in 241 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. X2BHS3,P0A5Y5 No NC_002945.3 Mycobrowser_v2 CDS 1670948 1671757 . + 0 Mb1520 inhA NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Mb1520, inhA, len: 269 aa. Equivalent to Rv1484,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 269 aa overlap). inhA, NADH-dependent enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.9) (see citations below). Identical to INHA_MYCTU|P46533 enoyl-[acyl-carrier-protein] reductase from Mycobacterium tuberculosis and G1155270 Mycobacterium bovis enoyl acp reductase. SOME SIMILARITY TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. X2BIC8,P0A5Y7 No lipid metabolism Rv1484 NC_002945.3 Mycobrowser_v2 CDS 1671763 1672797 . + 0 Mb1521 hemZ FERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME SYNTHETASE) Mb1521, hemZ, len: 344 aa. Equivalent to Rv1485,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 344 aa overlap). hemZ, ferrochelatase (EC 4.99.1.1) (see citation below), similar to many e.g. HEMZ_BACSU|P32396 ferrochelatase from Bacillus subtilus (310 aa), FASTA scores: opt:490, E(): 2e-24, (30.2% identity in 295 aa overlap); etc. BELONGS TO THE FERROCHELATASE FAMILY. X2BI24,P0A577 No intermediary metabolism and respiration Rv1485 NC_002945.3 Mycobrowser_v2 CDS 1672763 1673629 . - 0 Mb1522c CONSERVED HYPOTHETICAL PROTEIN Mb1522c, -, len: 288 aa. Equivalent to Rv1486c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 288 aa overlap). Conserved hypothetical protein, highly similar to YS07_MYCAV|O07402 hypothetical 33.5 kd protein mav321 from Mycobacterium avium (320 aa),FASTA scores: opt: 1217, E(): 0, (71.1% identity in 315 aa overlap). Weak similarity to AL079332|SCI5.07 hypothetical protein from Streptomyces coelicolor (259 aa), FASTA scores: opt: 131, E(): 0.29, (32.3% identity in 279 aa overlap). Start changed since original submission. X2BIJ0 No conserved hypotheticals Rv1486c NC_002945.3 Mycobrowser_v2 CDS 1673687 1674121 . + 0 Mb1523 CONSERVED MEMBRANE PROTEIN Mb1523, -, len: 144 aa. Equivalent to Rv1487, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved membrane protein. Highly similar to O07404|AF002133 MAV145 from Mycobacterium avium (145 aa), FASTA scores: opt: 667, E(): 0, (72.5% identity in 142 aa overlap). Also similar to AL079332|SCI5.05 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 344, E(): 1.3e-15,(44.8% identity in 134 aa overlap). Q7TZZ4 No cell wall and cell processes Rv1487 NC_002945.3 Mycobrowser_v2 CDS 1674143 1675288 . + 0 Mb1524 POSSIBLE EXPORTED CONSERVED PROTEIN Mb1524, -, len: 381 aa. Equivalent to Rv1488, len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 381 aa overlap). Possible exported conserved protein; contains possible N-terminal signal sequence. Similar to YBBK_ECOLI|P77367 hypothetical protein ybbK from Escherichia coli (305 aa), FASTA scores: opt: 716, E(): 0, (37.1% identity in 307 aa overlap). Similar to stomatin-like proteins e.g. AF065260|AF065260_1 Clostridium difficile (320 aa), FASTA scores: opt: 767,E(): 0, (42.3% identity in 307 aa overlap). X2BHS6,P63694 No cell wall and cell processes Rv1488 NC_002945.3 Mycobrowser_v2 CDS 1675298 1675654 . + 0 Mb1525 conserved protein Mb1525, -, len: 118 aa. Equivalent to Rv1489, len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 118 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium avium subsp. paratuberculosis and Streptomyces coelicolor e.g. AJ250017_1 insertion sequence IS900, Locus 3, putative invasion protein from M. paratuberculosis (138 aa), FASTA scores: opt: 120, E(): 0.26, (34.375% identity in 96 aa overlap); SCD6.11c|AL353815_11 possible integral membrane protein from Streptomyces coelicolor (136 aa), FASTA scores: opt: 106, E(): 2.2, (35.9% identity in 103 aa overlap). ORF predicted by GC plot. Replaces previous Rv1489c on other strand. Q7TZZ3 No conserved hypotheticals Rv1489 NC_002945.3 Mycobrowser_v2 CDS 1675688 1675918 . + 0 Mb1526 CONSERVED HYPOTHETICAL PROTEIN Mb1526, -, len: 76 aa. Equivalent to Rv1489A, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 76 aa overlap). Conserved hypothetical protein, similar to part of alpha subunit of many methylmalonyl-CoA mutases (~750 aa). Size difference suggests possible gene fragment although Mycobacterium tuberculosis has intact methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU PROBABLE METHYLMALONYL-COA MUTASE from Mycobacterium tuberculosis (750 aa), FASTA scores: opt: 258, E(): 3.2e-10, (73.35% identity in 60 aa overlap). ORF predicted by GC plot. Q7TZZ2 No conserved hypotheticals Rv1489A NC_002945.3 Mycobrowser_v2 CDS 1677954 1678712 . - 0 Mb1528c CONSERVED MEMBRANE PROTEIN Mb1528c, -, len: 252 aa. Equivalent to Rv1491c,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 252 aa overlap). Conserved membrane protein. Similar to hypothetical proteins from many organisms e.g. YDJZ_ECOLI|P76221 Escherichia coli (235 aa), FASTA scores: opt: 223, E():6.7e-07, (31.7% identity in 145 aa overlap); AL133252|SCE46.15 Streptomyces coelicolor (249 aa), FASTA scores: opt: 378, E(): 1.5e-17,(39.1% identity in 169 aa overlap). Also similar to M. tuberculosis hypothetical protein Rv0625c. X2BI71,P67118 No cell wall and cell processes Rv1491c NC_002945.3 Mycobrowser_v2 CDS 1678903 1680750 . + 0 Mb1529 mutA PROBABLE METHYLMALONYL-COA MUTASE SMALL SUBUNIT MUTA (MCM) Mb1529, mutA, len: 615 aa. Equivalent to Rv1492,len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 615 aa overlap). Probable mutA,Methylmalonyl-coa mutase small-subunit (EC 5.4.99.2),strong similarity to e.g. MUTA_STRCM|Q05064 methylmalonyl-coa mutase beta-subunit from Streptomyces cinnamonensis (616 aa), FASTA scores: opt: 1512, E(): 0,(45.9% identity in 628 aa overlap). Contains PS00213 Lipocalin signature, PS00544 Methylmalonyl-CoA mutase signature. BELONGS TO THE METHYLMALONYL-COA MUTASE FAMILY. X2BHS9,P65486 No lipid metabolism Rv1492 NC_002945.3 Mycobrowser_v2 CDS 1680751 1683003 . + 0 Mb1530 mutB PROBABLE METHYLMALONYL-COA MUTASE LARGE SUBUNIT MUTB (MCM) Mb1530, mutB, len: 750 aa. Equivalent to Rv1493,len: 750 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 750 aa overlap). Probable mutB,Methylmalonyl-coa mutase large-subunit (EC 5.4.99.2),strong similarity to e.g. MUTB_STRCM|Q05065 methylmalonyl-coa mutase alpha-subunit from Streptomyces cinnamonensis (733 aa), FASTA scores: opt: 3562, E(): 0,(75.8% identity in 730 aa overlap). Contains PS00544 Methylmalonyl-CoA mutase signature. BELONGS TO THE METHYLMALONYL-COA MUTASE FAMILY. X2BID6,P65488 No lipid metabolism Rv1493 NC_002945.3 Mycobrowser_v2 CDS 1683017 1683319 . + 0 Mb1531 maze4 possible antitoxin maze4 Mb1531, -, len: 100 aa. Equivalent to Rv1494, len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 100 aa overlap). Hypothetical unknown protein. X2BI30 No virulence, detoxification, adaptation Rv1494 NC_002945.3 Mycobrowser_v2 CDS 1683316 1683633 . + 0 Mb1532 mazf4 possible toxin mazf4 Mb1532, -, len: 105 aa. Equivalent to Rv1495, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 105 aa overlap). Conserved hypothetical protein, some similarity to Rv1942c|MTCY09F9.22 hypothetical protein from Mycobacterium tuberculosis (109 aa) (0.7% identity in 101 aa overlap) and Rv0659c,Rv1102c. X2BIK0,P64860 No virulence, detoxification, adaptation Rv1495 NC_002945.3 Mycobrowser_v2 CDS 1683630 1684634 . + 0 Mb1533 Possible transport system kinase Mb1533, -, len: 334 aa. Equivalent to Rv1496, len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 334 aa overlap). Possible transport system kinase (EC 2.7.-.-). Equivalent to NP_302220.1|NC_002677 putative kinase from Mycobacterium leprae (327 aa). Highly similar to several transport system kinases and NTPase transporters e.g. P27254|ARGK_ECOLI|B2918 LAO/AO transport system kinase (EC 2.7.-.-) from Escherichia coli K12 (331 aa) (see citation below); NP_311815.1|NC_002695 ATPase component of two convergent arginine transporter from Escherichia coli O157:H7 (331 aa); etc. Also similar to YPLE_CAUCR|P37895 hypothetical 34.6 kd protein in Caulobacter crescentus (326 aa), FASTA scores, opt: 1125, E(): 0, (55.7% identity in 316 aa overlap). X2BI73,P63578 No cell wall and cell processes Rv1496 NC_002945.3 Mycobrowser_v2 CDS 1801555 1802973 . + 0 Mb1643 pykA Probable pyruvate kinase pykA Mb1643, pykA, len: 472 aa. Equivalent to Rv1617,len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable pykA,pyruvate kinase (EC 2.7.1.40). FASTA best: Q46078 PYRUVATE KINASE from CORYNEBACTERIUM GLUTAMICUM (475 aa), opt: 2221, E(): 0, (72.2% identity in 468 aa overlap). BELONGS TO THE PYRUVATE KINASE FAMILY. Q7VEW3 No intermediary metabolism and respiration Rv1617 NC_002945.3 Mycobrowser_v2 CDS 1684687 1685976 . + 0 Mb1534 lipL PROBABLE ESTERASE LIPL Mb1534, lipL, len: 429 aa. Equivalent to Rv1497,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 429 aa overlap). Probable LipL, esterase (EC 3.1.-.-), very similar to Mycobacterium tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923, Rv2463, Rv3775, etc. Also similar to G151214|M68491 esterase estA from Pseudomonas sp (389 aa),FASTA scores: opt: 604, E(): 1e-31, (34.4% identity in 389 aa overlap). Q7TZZ1 No intermediary metabolism and respiration Rv1497 NC_002945.3 Mycobrowser_v2 CDS 1717623 1718750 . + 0 Mb1560 conserved protein Mb1560, -, len: 375 aa. Equivalent to Rv1533, len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 375 aa overlap). Conserved hypothetical protein. Similar to 2NPD_NEUCR|Q01284 2-nitropropane dioxygenase precursor (378 aa), fasta scores: opt: 279,E(): 9.1e-11, (31.3% identity in 256 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1894c, Rv0021c, Rv3553, Rv2781c. Q7TZX5 No conserved hypotheticals Rv1533 NC_002945.3 Mycobrowser_v2 CDS 1686049 1686822 . - 0 Mb1535c PROBABLE METHYLTRANSFERASE Mb1535c, -, len: 257 aa. Equivalent to possible methyltransferase TMAG_02827 from Mycobacterium tuberculosis strain SUMu001 (100% identity with 256 aa overlap). Similar to Rv1498c, len: 205 aa, from Mycobacterium tuberculosis strain H37Rv, (79% identity in 205 aa overlap). Probable methyltransferase (EC 2.1.1.-). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Contains PS00017 ATP/GTP-binding site motif A. Mb1535c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BIE0 No NC_002945.3 Mycobrowser_v2 CDS 1751572 1753314 . - 0 Mb1588c treZ Maltooligosyltrehalose trehalohydrolase TreZ Mb1588c, treZ, len: 580 aa. Equivalent to Rv1562c,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 580 aa overlap). treZ (previously called glgZ), Maltooligosyltrehalose trehalohydrolase,confirmed biochemically (see citation below). Similar to Q44316|D63343 TREZ MALTOOLIGOSYL TREHALOSE TREHALOHYDROLASE from ARTHROBACTER SP (598 aa), FASTA scores: opt: 2071, E(): 0, (52.2% identity in 582 aa overlap); also similar to 1,4-alpha-glucan branching enzymes e.g. GLGB_BACST|P30538 (639 aa), FASTA scores: opt: 313, E(): 3.8e-13, (27.5% identity in 462 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv1326c|glgB, and Rv1563c treY (previously glgY). Q7VEY8 No NC_002945.3 Mycobrowser_v2 CDS 1687596 1688624 . + 0 Mb1538 PROBABLE GLYCOSYLTRANSFERASE Mb1538, -, len: 342 aa. Equivalent to Rv1500, len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 342 aa overlap). Probable glycosyltransferase (EC 2.-.-.- ), hydrophobic domain near C-terminus. Some similarity to putative glycosyl-transferases from Bacillus subtilis e.g. O34319|YKCC_BACSU (323 aa), opt: 490, E(): 6.1e-25,(28.85% identity in 312 aa overlap) and to N-acetyl glucosamine transferases. Also similar to G1001347 hypothetical 36.7 kDa protein (318 aa), FASTA scores: opt: 523, E(): 7.2e-26, (30.6% identity in 307 aa overlap). Q7TZY7 No intermediary metabolism and respiration Rv1500 NC_002945.3 Mycobrowser_v2 CDS 1688636 1689457 . + 0 Mb1539 CONSERVED HYPOTHETICAL PROTEIN Mb1539, -, len: 273 aa. Equivalent to Rv1501, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Conserved hypothetical protein, some similarity to O06374|Rv3633|MTCY15C10.19C hypothetical protein from Mycobacterium tuberculosis,FASTA scores: E(): 3.9e-10, (27.5% identity in 280 aa overlap). X2BHT7 No conserved hypotheticals Rv1501 NC_002945.3 Mycobrowser_v2 CDS 1689670 1690020 . + 0 Mb1540 HYPOTHETICAL PROTEIN [FIRST PART] Mb1540, -, len: 116 aa. Equivalent to the 5' end of Rv1502, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, (94.7% identity in 114 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. Q7TZY6 No NC_002945.3 Mycobrowser_v2 CDS 1689999 1690568 . + 0 Mb1541 HYPOTHETICAL PROTEIN [SECOND PART] Mb1541, -, len: 189 aa. Equivalent to the 3' end of Rv1502, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 189 aa overlap). Hypothetical unknown protein. Q7TZY5 No NC_002945.3 Mycobrowser_v2 CDS 1728439 1728849 . - 0 Mb1569c glbN hemoglobin glbn Mb1569c, glbN, len: 136 aa. Equivalent to Rv1542c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Probable glbN,hemoglobin. Belongs to the protozoan/cyanobacterial globin family. Similar to myoglobins e.g. GLB_PARCA|P15160 myoglobin (hemoglobin) paramecium (116 aa), FASTA scores,opt: 284, E(): 2.1e -13, (35.7% identity in 115 aa overlap). Similar to Mycobacterium tuberculosis hypothetical globin, Rv2470. X2BHW6,P0A593 No NC_002945.3 Mycobrowser_v2 CDS 1698302 1701625 . - 0 Mb1549c mmpL12 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL12 Mb1549c, mmpL12, len: 1107 aa. Equivalent to Rv1522c, len: 1146 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1107 aa overlap). Probable mmpL12, conserved transmembrane transport protein (see first citation below), member of RND superfamily. Strong similarity to many Mycobacterial membrane proteins e.g. Q49619|G466786 putative transport protein B1170_C1_181 from Mycobacterium leprae (1008 aa), FASTA scores: opt: 2418, E(): 0, (51.0% identity in 1006 aa overlap); etc. Also highly similar to MmpL8|MTCY48.08c|Rv3823c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis, FASTA score: (34.3% identity in 376 aa overlap); and some similarity to MmpL10|MTCY20G9|Rv1183 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN, FASTA score: (27.2% identity in 1011 aa overlap). BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (c-a) omitting a stop codon,leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Q7TZY0 No NC_002945.3 Mycobrowser_v2 CDS 1750927 1751145 . + 0 Mb1586 vapb11 possible antitoxin vapb11 Mb1586, -, len: 72 aa. Equivalent to Rv1560, len: 72 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 72 aa overlap). Conserved hypothetical protein, part of a Mycobacterial tuberculosis family of proteins e.g. Q10848|Rv2009|MTCY39.08c (80 aa), FASTA score: (54.4% identity in 68 aa overlap); Q10799|Rv2871|MTCY274.02 (85 aa); O50456|Rv1241|MTV006.13 (86 aa), O06243|Rv2132|MTCY270.36C (76 aa); etc. X2BI78 No virulence, detoxification, adaptation Rv1560 NC_002945.3 Mycobrowser_v2 CDS 1701666 1702709 . + 0 Mb1550 Probable methyltransferase Mb1550, -, len: 347 aa. Equivalent to Rv1523, len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 347 aa overlap). Probable methyltransferase (EC 2.1.1.-), similar to G560513|U0002O Mycobacterium leprae (270 aa), FASTA scores: opt: 965,E(): 0, (60.3% identity in 247 aa overlap). Also similar to many e.g. Q54303|X86780 METHYLTRANSFERASE RAPM from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 323, E(): 1e-15, (41.2% identity in 136 aa overlap). And similar to Mycobacterium tuberculosis hypothetical proteins Rv2952, Rv1405c, Rv1403c, Rv0839. Start uncertain. Q7VEZ4 No intermediary metabolism and respiration Rv1523 NC_002945.3 Mycobrowser_v2 CDS 1690741 1691889 . - 0 Mb1542c CONSERVED HYPOTHETICAL PROTEIN Mb1542c, -, len: 382 aa. Equivalent to Rv1503c and Rv1504c, len: 182 aa and 199 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 182 aa overlap and 100% identity in 199 aa overlap). Conserved hypothetical protein, similar to C-terminal region of P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN from Escherichia coli (376 aa), FASTA scores: opt: 565,E(): 0, (49.4% identity in 170 aa overlap) and similar to N-terminal region of P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN from Escherichia coli (376 aa), FASTA scores: opt: 863, E(): 0, (68.0% identity in 194 aa overlap); Rv1503c and Rv1504c are both similar to RFFA_ECOLI but are separated by a stop codon, sequence appears to be correct so possible pseudogene. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1503c and Rv1504c exist as 2 genes. In Mycobacterium bovis, a single base transversion (t-g) leads to a single product. Q7TVB9 No conserved hypotheticals Rv1503c NC_002945.3 Mycobrowser_v2 CDS 1692026 1692691 . - 0 Mb1543c CONSERVED HYPOTHETICAL PROTEIN Mb1543c, -, len: 221 aa. Equivalent to Rv1505c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 221 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins and glycosylases e.g. P71063|O08181 HYPOTHETICAL 22.5 KD PROTEIN YVFD from Bacillus subtilis (216 aa), FASTA scores: E(): 2.4e-08, (25.5% identity in 196 aa overlap). Q7TZY4 No conserved hypotheticals Rv1505c NC_002945.3 Mycobrowser_v2 CDS 1692884 1693648 . + 0 Mb1544 CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN Mb1544, -, len: 254 aa. Equivalent to Rv1517, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 254 aa overlap). Conserved hypothetical transmembrane protein, similar to G466802|LEPB1170_F2_64 from Mycobacterium leprae (230 aa), FASTA scores: opt: 282, E(): 2.2e-11, (34.1% identity in 255 aa overlap). Also similar to Mycobacterium tuberculosis Rv3821|MTCY409.09c (237 aa) (36.3% identity in 256 aa overlap); and Rv3481c. Q7TZY3 No cell wall and cell processes Rv1517 NC_002945.3 Mycobrowser_v2 CDS 1693657 1694616 . + 0 Mb1545 CONSERVED HYPOTHETICAL PROTEIN Mb1545, -, len: 319 aa. Equivalent to Rv1518, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 319 aa overlap). Conserved hypothetical protein, possibly a glycosyl transferase involved in exopolysaccharide synthesis, similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from SYNECHO CYSTIS sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap). Q7TZY2 No conserved hypotheticals Rv1518 NC_002945.3 Mycobrowser_v2 CDS 1695041 1696081 . + 0 Mb1547 probable sugar transferase Mb1547, -, len: 346 aa. Equivalent to Rv1520, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 346 aa overlap). Probable sugar transferase (EC 2.-.-.-), similar to several e.g. AB010970|AB010970_6 Streptococcus mutans glycosyltransferase (465 aa), FASTA scores: opt: 381, E(): 1.2e-18, (31.7% identity in 240 aa overlap); O34234|Y07786 SUGAR TRANSFERASE from Vibrio cholerae (337 aa), FASTA scores: opt: 214, E(): 8.4e-05, (25.9% identity in 212 aa overlap). Also strongly similar to Mycobacterium tuberculosis probable sugar transferase Rv1516c. X2BIL2 No intermediary metabolism and respiration Rv1520 NC_002945.3 Mycobrowser_v2 CDS 1696315 1698066 . + 0 Mb1548 fadD25 probable fatty-acid-amp ligase fadd25 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb1548, fadD25, len: 583 aa. Equivalent to Rv1521,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 583 aa overlap). Probable fadD25,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to many e.g. P71495|U75685 ACYL-CoA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486,E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc. Q7TZY1 No NC_002945.3 Mycobrowser_v2 CDS 1725225 1726205 . - 0 Mb1565c ansA Probable L-aparaginase ansA Mb1565c, ansA, len: 326 aa. Equivalent to Rv1538c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable ansA,L-aparaginase, most similar to ASPG_BACLI|P30363 L-asparaginase (322 aa), FASTA scores: opt: 417, E(): 8.8e-19, (30.9% identity in 314 aa overlap). Contains PS00917 Asparaginase / glutaminase active site signature 2. X2BIG6,P63628 No NC_002945.3 Mycobrowser_v2 CDS 1702739 1703983 . + 0 Mb1551 Probable glycosyltransferase Mb1551, -, len: 414 aa. Equivalent to Rv1524, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 414 aa overlap). Probable glycosyltransferase (EC 2.4.1.-), similar to many e.g. P96559|U84349 GLYCOSYLTRANSFERASE GTFB from Amycolatopsis orientalis (407 aa), FASTA scores: opt: 363, E(): 6.2e-23,(28.8% identity in 430 aa overlap); also high similarity to Rv1526c|MTCY19G5.02 Mycobacterium tuberculosis hypothetical protein (58.7% identity in 416 aa overlap); and AF143772|AF143772_15 glycosyltransferase gtfB from Mycobacterium avium strain 215 (418 aa), FASTA scores: opt: 1801, E(): 0, (65.2% identity in 417 aa overlap). X2BI44,P64866 No intermediary metabolism and respiration Rv1524 NC_002945.3 Mycobrowser_v2 CDS 1704030 1704815 . + 0 Mb1552 wbbL2 POSSIBLE RHAMNOSYL TRANSFERASE WBBL2 Mb1552, wbbL2, len: 261 aa. Equivalent to Rv1525,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Possible wbbL2,rhamnosyl transferase (EC 2.-.-.-), showing weak similarity to several rhamnosyl transferases. Similar to AF105060|AF105060_1 Riftia pachyptila endosymbiont (746 aa), FASTA scores: opt: 183, E(): 0.00013, (35.2% identity in 105 aa overlap). X2BIL7 No NC_002945.3 Mycobrowser_v2 CDS 1704793 1706073 . - 0 Mb1553c Probable glycosyltransferase Mb1553c, -, len: 426 aa. Equivalent to Rv1526c,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 426 aa overlap). Probable glycosyltransferase (EC 2.4.1.-), highly similar to G467196 Protein L518_C2_147 from Mycobacterium leprae (421 aa), FASTA scores, opt: 1497, E(): 0, (55.0% identity in 424 aa overlap); similar to G452504 rhamnosyltransferase (24.7% identity in 433 aa overlap); and P96565|U84350 GLYCOSYLTRANSFERASE GTFE from Amycolatopsis orientalis (408 aa), E(): 3.4e-24, (28.4% identity in 429 aa overlap), also high similarity to Rv1524|MTCY19G5.04c (58.7 % identity in 416 aa overlap). X2BI86,P64870 No intermediary metabolism and respiration Rv1526c NC_002945.3 Mycobrowser_v2 CDS 1706096 1712422 . - 0 Mb1554c pks5 Probable polyketide synthase pks5 Mb1554c, pks5, len: 2108 aa. Equivalent to Rv1527c,len: 2108 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 2108 aa overlap). Probable pks5,polyketide synthase, highly similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from Mycobacterium bovis (2110 aa), FASTA scores: opt: 6270,E(): 0, (63.6% identity in 2126 aa overlap). Q7VEZ3 No NC_002945.3 Mycobrowser_v2 CDS 1712966 1713463 . - 0 Mb1555c papA4 PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA4 Mb1555c, papA4, len: 165 aa. Equivalent to Rv1528c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Probable papA4,conserved polyketide synthase (PKS) associated protein; shows some similarity to C-terminal part of hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. Z97188|MTCY409_10 Mycobacterium tuberculosis cosmid (468) (37.9% identity in 66 aa overlap); or U00010_11 Mycobacterium leprae cosmid B1170 (35.7% identity in 84 aa overlap). Also similar to Mycobacterium tuberculosis PKS-associated proteins Rv1182, Rv3824c,Rv3820c. Q7TZX9 No NC_002945.3 Mycobrowser_v2 CDS 1713515 1715269 . + 0 Mb1556 fadD24 probable fatty-acid-amp ligase fadd24 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb1556, fadD24, len: 584 aa. Equivalent to Rv1529,len: 584 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 584 aa overlap). Probable fadD24,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA score: (65.6% identity in 582 aa overlap); and many other fatty-acid-CoA synthetases from Mycobacteria e.g. fadD25|MTCY19G5_7 from Mycobacterium tuberculosis (583 aa), FASTA score: (68.7% identity in 584 aa overlap); fadD28|MTCY24G1_8 from Mycobacterium tuberculosis (580 aa), FASTA score: (66.0% identity in 582 aa overlap); NP_301232.1|NC_002677|U00010_6 from Mycobacterium leprae (372 aa), FASTA score: (57.6% identity in 342 aa overlap); FADD23|Rv3826|MTCY409.04c from Mycobacterium tuberculosis (584 aa), FASTA score: (63.2% identity in 584 aa overlap); etc. Q7TZX8 No NC_002945.3 Mycobrowser_v2 CDS 1715386 1716489 . + 0 Mb1557 adh Probable alcohol dehydrogenase adh Mb1557, adh, len: 367 aa. Equivalent to Rv1530,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 367 aa overlap). Probable adh, alcohol dehydrogenase (EC 1.1.1.1), zinc-dependent, similar to many e.g. AE0009|AE000958_23 Archaeoglobus fulgidus section 1 (402 aa), FASTA scores: opt: 423, E(): 1.8e-19,(31.7% identity in 341 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Q7VEZ2 No intermediary metabolism and respiration Rv1530 NC_002945.3 Mycobrowser_v2 CDS 1723869 1725260 . + 0 Mb1564 dinX probable dna polymerase iv dinx (pol iv 1) (dna nucleotidyltransferase (dna-directed)) Mb1564, dinX, len: 463 aa. Equivalent to Rv1537,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 463 aa overlap). Probable dinX, DNA polymerase IV. Similar to umuC, mucB, samb, and impb (uv protection and mutation) e.g. IMPB_SALTY|P18642 impb protein from Salmonella typhimurium (424 aa), FASTA scores, opt: 386, E(): 1.7e-17, (27.5% identity in 415 aa overlap). Also similar to Mycobacterium tuberculosis Rv3056. X2BHV7,P63986 No information pathways Rv1537 NC_002945.3 Mycobrowser_v2 CDS 1726257 1726865 . + 0 Mb1566 lspA Probable lipoprotein signal peptidase lspA Mb1566, lspA, len: 202 aa. Equivalent to Rv1539,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 202 aa overlap). Probable lspA,lipoprotein signal peptidase (EC 3.4.23.36), similar to several e.g. LSPA_PSEFL|P17942 (170 aa), FASTA scores: opt: 299, E(): 2.6e-12, (38.3% identity in 167 aa overlap). X2BI59,P65263 No cell wall and cell processes Rv1539 NC_002945.3 Mycobrowser_v2 CDS 1726858 1727784 . + 0 Mb1567 CONSERVED HYPOTHETICAL PROTEIN MEMBER OF yabO/yceC/yfiI FAMILY Mb1567, -, len: 308 aa. Equivalent to Rv1540, len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 308 aa overlap). Member of the yabO/yceC/yfiI family of hypothetical proteins, similar to P44445|YFII_HAEIN hypothetical protein HI0176 from Haemophilus influenzae (324 aa), FASTA scores: opt: 437,E(): 1.2e-22, (33.2% identity in 322 aa overlap). Equivalent to AL049478|MLCL458_13 hypothetical protein from Mycobacterium leprae (308 aa), (89.3% identity in 307 aa overlap). Contains PS01129 hypothetical yabO/yceC/yfiI family signature. X2BIN2,P0A5T3 No conserved hypotheticals Rv1540 NC_002945.3 Mycobrowser_v2 CDS 2086393 2086809 . - 0 Mb1877c blai transcriptional repressor blai Mb1877c, -, len: 138 aa. Equivalent to Rv1846c,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 138 aa overlap). Possible transcriptional regulatory protein. Equivalent to MLCB1788.17|AL008609 hypothetical protein from Mycobacterium leprae (142 aa), FASTA scores: opt: 736 E(): 0, (95.1% identity in 123 aa overlap). Also similar to BLAI_BACLI|P06555 penicillinase repressor (128 aa), fasta scores: opt: 114, E(): 0.12, (23.7% identity in 131 aa overlap). Q7TZF9 No regulatory proteins Rv1846c NC_002945.3 Mycobrowser_v2 CDS 1729077 1730102 . + 0 Mb1570 POSSIBLE FATTY ACYL-COA REDUCTASE Mb1570, -, len: 341 aa. Equivalent to Rv1543, len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 341 aa overlap). Possible fatty-acyl CoA reductase (EC 1.2.1.-), highly similar to P94129|U77680 FATTY ACYL-COA REDUCTASE ACR1 from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 899, E(): 0,(48.5% identity in 293 aa overlap). Also highly similar to acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty acyl-CoA reductase from Mycobacterium tuberculosis (650 aa). Also highly similar to many oxidoreductases short-chain family. X2BIH0,P66780 No lipid metabolism Rv1543 NC_002945.3 Mycobrowser_v2 CDS 1730107 1730910 . + 0 Mb1571 Possible ketoacyl reductase Mb1571, -, len: 267 aa. Equivalent to Rv1544, len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 267 aa overlap). Possible ketoacyl reductase (EC 1.3.1.-), highly similar to Z97179|MLCL383_26 putative oxidoreductase from Mycobacterium leprae (268 aa), FASTA score: (43.0% identity in 270 aa overlap). Also highly similar to others e.g. T29125 ketoacyl reductase homolog from Streptomyces coelicolor (276 aa); NP_470957.1|NC_003212 protein similar to ketoacyl reductases from Listeria innocua (253 aa); HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp. strain PCC 7120 (287 aa), FASTA scores: opt: 379, E(): 7.5e-18, (31.6% identity in 250 aa overlap); etc. And highly similar to many oxidoreductases short-chain family. Also highly similar to Rv2509 from Mycobacterium tuberculosis (268 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7VEY9 No lipid metabolism Rv1544 NC_002945.3 Mycobrowser_v2 CDS 1731208 1731639 . + 0 Mb1573 conserved protein Mb1573, -, len: 143 aa. Equivalent to Rv1546, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 143 aa overlap). Conserved hypothetical protein, similar to O05902|Rv0910|MTCY21C12.04 Hypothetical protein from Mycobacterium tuberculosis (144 aa), FASTA scores: E(): 5e-30, (37.3% identity in 142 aa overlap). X2BIA1 No conserved hypotheticals Rv1546 NC_002945.3 Mycobrowser_v2 CDS 1731707 1735261 . + 0 Mb1574 dnaE1 probable dna polymerase iii (alpha chain) dnae1 (dna nucleotidyltransferase) Mb1574, dnaE1, len: 1184 aa. Equivalent to Rv1547,len: 1184 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1184 aa overlap). Probable dnaE1,DNA polymerase III, alpha chain (EC 2.7.7.7), similar to e.g. DP3A_ECOLI|P10443 dna polymerase III, alpha chain (1160 aa), FASTA scores: opt: 1789, E(): 0, (36.5% identity in 1193 aa overlap). Also similar to M. tuberculosis, DnaE2|Rv3370c. X2BHX1,P63978 No NC_002945.3 Mycobrowser_v2 CDS 1766009 1767430 . - 0 Mb1602c Probable phiRV1 phage protein Mb1602c, -, len: 473 aa. Equivalent to Rv1576c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 473 aa overlap). Probable phiRV1 phage protein (capsid subunit) (see citation below). Highly similar to hypothetical Mycobacterium tuberculosis protein Rv2650c|MTCY441.19 phiRV2 phage related protein, FASTA scores: opt: 2782, E(): 0, (89.1% identity in 468 aa overlap). Q7VEY0 No insertion seqs and phages Rv1576c NC_002945.3 Mycobrowser_v2 CDS 1735310 1737346 . - 0 Mb1575c PPE21 ppe family protein ppe21 Mb1575c, PPE21, len: 678 aa. Equivalent to Rv1548c,len: 678 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 678 aa overlap). Member of the M. tuberculosis PPE family, similar to several e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kd protein in hsp65 3' region (517 aa), FASTA scores: opt:1142, E(): 0, (40.6% identity in 616 aa overlap); also similar to MTCY31.06c (54.9% identity in 381 aa overlap). Q7TZX3 No NC_002945.3 Mycobrowser_v2 CDS 1739460 1741325 . + 0 Mb1577 plsB1 Possible acyltransferase plsB1 Mb1577, plsB1, len: 621 aa. Equivalent to Rv1551,len: 621 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 621 aa overlap). Possible plsB1,acyltransferase (EC 2.-.-.-), similar to PLSB_HAEIN|P44857 glycerol-3-phosphate acyltransferase from Haemophilus influenzae (810 aa), FASTA scores: opt: 434, E(): 6.2e-22,(27.6% identity in 395 aa overlap). Also similar to Rv2482c|plsB2 Probable glycerol-3-phosphate acyltransferase from M.tuberculosis (789 aa). X2BIP2,P65735 No NC_002945.3 Mycobrowser_v2 CDS 1741696 1743447 . + 0 Mb1578 frdA PROBABLE FUMARATE REDUCTASE [FLAVOPROTEIN SUBUNIT] FRDA (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) Mb1578, frdA, len: 583 aa. Equivalent to Rv1552,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 583 aa overlap). Probable frdA, fumarate reductase, flavoprotein subunit (EC 1.3.99.1), highly similar to others e.g. P00363|FRDA_ECOLI fumarate reductase flavoprotein subunit from Escherichia coli strain K12 (601 aa), FASTA scores: opt: 2102, E(): 0,(54.7% identity in 585 aa overlap); NP_232284.1|NC_002505 fumarate reductase, flavoprotein subunit from Vibrio cholerae (602 aa); frdA|NP_438995.1|NC_000907 fumarate reductase, flavoprotein subunit from Haemophilus influenzae (599 aa); etc. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD). X2BIA5,P64175 No intermediary metabolism and respiration Rv1552 NC_002945.3 Mycobrowser_v2 CDS 1749600 1750889 . + 0 Mb1585 ilvA Probable threonine dehydratase ilvA Mb1585, ilvA, len: 429 aa. Equivalent to Rv1559,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 429 aa overlap). Probable ilvA,threonine dehydratase (EC 4.3.1.19), biosynthetic protein,similar to several e.g. THD1_CORGL|Q04513 threonine dehydratase biosynthetic (436 aa), FASTA scores: opt: 1694, E(): 0, (61.9% identity in 415 aa overlap). Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. X2BII6,P66898 No intermediary metabolism and respiration Rv1559 NC_002945.3 Mycobrowser_v2 CDS 1743450 1744574 . + 0 Mb1579 frdBC probable fumarate reductase [membrane anchor subunit] frdc (fumarate dehydrogenase) (fumaric hydrogenase) Mb1579, frdBC, len: 374 aa. Equivalent to Rv1553 (frdB) and Rv1554 (frdC), len: 247 aa and len: 126 aa,from Mycobacterium tuberculosis strain H37Rv, (100% identity in 247 aa overlap and 99.2% identity in 126 aa overlap). Probable frdB, fumarate reductase, iron-sulfur subunit (EC 1.3.99.1), highly similar to others e.g. P00364|FRDB_ECOLI fumarate reductase iron-sulfur protein from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 846, E(): 0, (50.0% identity in 242 aa overlap); P20921|FRDB_PROVU FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Proteus vulgaris (245 aa); G64097 fumarate reductase (EC 1.3.99.1) iron-sulfur protein from Haemophilus influenzae (276 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. And probable frdC, fumarate reductase, membrane-anchor subunit (EC 1.3.99.1), highly similar to others e.g. P03805|FRDC_ECOLI fumarate reductase 15 kDa hydrophobic protein from Escherichia coli strain K12 (131 aa), FASTA scores, opt: 268, E(): 3.9e-10, (31.1% identity in 122 aa overlap); NP_458780.1|NC_003198 fumarate reductase complex subunit C; membrane anchor polypeptide from Salmonella enterica subsp. enterica serovar Typhi (131 aa); P20923|FRDC_PROVU FUMARATE REDUCTASE 15 KD HYDROPHOBIC PROTEIN from Proteus vulgaris (131 aa); etc. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg) leads to a single product. Q7TZX1 No intermediary metabolism and respiration Rv1553 NC_002945.3 Mycobrowser_v2 CDS 1744571 1744948 . + 0 Mb1580 frdD PROBABLE FUMARATE REDUCTASE [MEMBRANE ANCHOR SUBUNIT] FRDD (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) Mb1580, frdD, len: 125 aa. Equivalent to Rv1555,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 125 aa overlap). Probable frdD, fumarate reductase, membrane-anchor subunit (EC 1.3.99.1), similar to others e.g. P03806|FRDD_ECOLI fumarate reductase 13 kDa hydrophobic protein from Escherichia coli strain K12 (119 aa), FASTA scores: opt: 212, E(): 4.4e-08, (36.8% identity in 106 aa overlap); etc. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD). X2BII1,P67644 No intermediary metabolism and respiration Rv1555 NC_002945.3 Mycobrowser_v2 CDS 1745016 1745624 . + 0 Mb1581 Possible regulatory protein Mb1581, -, len: 202 aa. Equivalent to Rv1556, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 202 aa overlap). Possible regulatory protein, similar to X86780|SHGCPIR2|g987088 orfY,regulator of antibiotic transport complexes from Streptomyces hygroscopicus (204 aa), FASTA score: opt: 251, E(): 1.7e-10, (33.8% identity in 201 aa overlap) and others. X2BI74,P67437 No regulatory proteins Rv1556 NC_002945.3 Mycobrowser_v2 CDS 1745763 1746209 . + 0 Mb1582 mmpS6 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS6 Mb1582, mmpS6, len: 148 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv. Probable mmpS6,conserved membrane protein (see citations below), highly similar to other Mycobacterial proteins e.g. P54880|MMS4_MYCLE|ML2377|U1740W|MMPS4 Putative membrane protein from Mycobacterium leprae (154 aa), FASTA scores: opt: 521, E(): 4.7e-29, (53.06% identity in 147 aa overlap); P95212|MMPS1|MMS1_MYCTU|Rv0403c|MT0415|MTCY04D9.16c PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 518, E(): 7.2e-29, (56.75% identity in 141 aa overlap); O53736|MMS4_MYCTU|MMPS4|Rv0451c|MT0467|MTV037.15c PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium tuberculosis (140 aa), FASTA scores: opt: 498, E(): 1.8e-27, (52.85% identity in 140 aa overlap); etc. BELONGS TO THE MMPS FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region. Q7TZX0 No NC_002945.3 Mycobrowser_v2 CDS 1763225 1763905 . + 0 Mb1597 bioD dethiobiotin synthetase biod Mb1597, bioD, len: 226 aa. Equivalent to Rv1570,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Probable bioD,dethiobiotin synthetase (EC 6.3.3.3). Similar to many e.g. BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa),FASTA results: opt: 1059, E(): 0, (74.8% identity in 222 aa overlap). BELONGS TO THE DETHIOBIOTIN SYNTHETASE FAMILY. X2BIR2,O52587 No intermediary metabolism and respiration Rv1570 NC_002945.3 Mycobrowser_v2 CDS 1746206 1749109 . + 0 Mb1583 mmpL6 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL6 Mb1583, mmpL6, len: 967 aa. Equivalent to 3' end of Rv1557, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 384 aa overlap). Probable mmpL6, conserved transmembrane transport protein (see citations below). Member of RND superfamily, with strong similarity to other members of large Mycobacterial membrane protein family belonging to RND superfamily e.g. Q11171|MML2_MYCTU|MMPL2|Rv0507|MT0528|MTCY20G9.34 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 4142, E(): 0, (64.4% identity in 947 aa overlap); O53735|MML4_MYCTU|MMPL4|Rv0450c|MT0466|MTV037.14c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis (967 aa), FASTA scores: opt: 4035, E(): 0, (61.5% identity in 948 aa overlap); P54881|MML4_MYCLE|MMPL4|ML2378|U1740V Putative membrane protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3961, E(): 0, (60.95% identity in 945 aa overlap); etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region. Q7TZW9 No NC_002945.3 Mycobrowser_v2 CDS 1749119 1749565 . + 0 Mb1584 conserved protein Mb1584, -, len: 148 aa. Equivalent to Rv1558, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 148 aa overlap). Conserved hypothetical protein, similar to other Mycobacterial tuberculosis proteins e.g. P71854|MTCY03C7.09c|Rv3547 (151 aa), FASTA scores opt: 330, E(): 9.1e-17, (39.7% identity in 151 aa overlap); also Q11057|Rv1261c (149 aa), and O53328|Rv3178 (119 aa). Similar also to AF072709|AF072709_5 Hypothetical protein with a new amplifiable element AUD4 from Streptomyces lividans (149 aa), FASTA scores: opt: 695,E(): 0, (69.1% identity in 149 aa overlap). X2BHX8,P64876 No conserved hypotheticals Rv1558 NC_002945.3 Mycobrowser_v2 CDS 1753307 1754041 . - 0 Mb1589c treYb Maltooligosyltrehalose synthase TreYb [SECOND PART] Mb1589c, treYb, len: 244 aa. Equivalent to the 3' end of Rv1563c, len: 765 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 244 aa overlap). treY (previously called glgY), maltooligosyl trehalose synthase, confirmed biochemically (see citation below). Strong similarity to Q44315|63343 TREY MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775 aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in 789 aa overlap). Some similarity to alpha-amylases and to MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse conversion of maltodextrins to maltooligosyl trehaloses. Also similar to Mycobacterium tuberculosis glgB (Rv1326c),treZ (Rv1562c). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1563c/treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp splits Rv1563c into two parts, treYa and treYb. Q7VEY7 No NC_002945.3 Mycobrowser_v2 CDS 1754046 1754798 . - 0 Mb1590c treYa Maltooligosyltrehalose synthase TreYa [FIRST PART] Mb1590c, treYa, len: 250 aa. Equivalent to the 5' end of Rv1563c, len: 765 aa, from Mycobacterium tuberculosis strain H37Rv, (97.4% identity in 191 aa overlap). treY (previously called glgY), maltooligosyl trehalose synthase, confirmed biochemically (see citation below). Strong similarity to Q44315|63343 TREY MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775 aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in 789 aa overlap). Some similarity to alpha-amylases and to MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse conversion of maltodextrins to maltooligosyl trehaloses. Also similar to Mycobacterium tuberculosis glgB (Rv1326c),treZ (Rv1562c). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1563c/treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp splits Rv1563c in two parts, treYa and treYb. Q7VEY6 No NC_002945.3 Mycobrowser_v2 CDS 1754802 1756967 . - 0 Mb1591c treX probable maltooligosyltrehalose synthase trex Mb1591c, treX, len: 721 aa. Equivalent to Rv1564c,len: 721 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 721 aa overlap). Probable treX (previously called glgX), Maltooligosyltrehalose synthase. Strong similarity to D83245|g1890053 treX, glycogen debranching enzyme (glgX) from Sulfolobus acidocaldarius (713 aa), FASTA score: opt: 2396, E(): 0, (48.4% identity in 709 aa overlap); similar to GLGX_HAEIN|P45178 glycogen operon protein glgx (659 aa), FASTA scores: opt: 1512,E(): 0, (42.3% identity in 645 aa overlap). X2BI83,P0A4Y5 No NC_002945.3 Mycobrowser_v2 CDS 1757006 1759195 . - 0 Mb1592c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1592c, -, len: 729 aa. Equivalent to Rv1565c,len: 729 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 729 aa overlap). Conserved hypothetical membrane protein, some similarity to O05402 HYPOTHETICAL 72.2 KD PROTEIN from Bacillus subtilis (634 aa), FASTA results: opt: 384, E(): 4.8e-17, (29.1% identity in 378 aa overlap); and to Y392_HAEIN|P43993 hypothetical protein hi0392 from H. influenzae (245 aa), FASTA results: opt: 265, E(): 5.5e-10, (28.3% identity in 247 aa overlap). C-terminal half equivalent to AL049478|MLCL458_19 (274 aa) (78.5% identity in 274 aa overlap). Also similar to M. tuberculosis hypothetical proteins Rv0111, Rv0228, Rv1254,Rv0517. N-terminal half hydrophobic. Q7TZW8 No cell wall and cell processes Rv1565c NC_002945.3 Mycobrowser_v2 CDS 1788030 1788650 . + 0 Mb1628 hisH Probable amidotransferase hisH Mb1628, hisH, len: 206 aa. Equivalent to Rv1602,len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 206 aa overlap). Probable hisH,amidotransferase (EC 2.4.2.-). Similar to many e.g. HIS5_STRCO|P16249 from Streptomyces coelicolor (222 aa),FASTA results: opt: 872, E():0, (61.0% identity in 210 aa overlap). Contains glutamine amidotransferases class-I active site (PS00442). BELONGS TO THE HISH FAMILY. X2BHZ9,P59957 No intermediary metabolism and respiration Rv1602 NC_002945.3 Mycobrowser_v2 CDS 1759294 1759986 . - 0 Mb1593c Possible inv protein Mb1593c, -, len: 230 aa. Equivalent to Rv1566c,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 230 aa overlap). Possible inv protein,probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa overlap); also to putative invasins 1,2 (O07390,O07391) from M. avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478, Rv0024, Rv2190c. Q7VEY5 No virulence, detoxification, adaptation Rv1566c NC_002945.3 Mycobrowser_v2 CDS 1760758 1762071 . + 0 Mb1595 bioA adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioa Mb1595, bioA, len: 437 aa. Equivalent to Rv1568,len: 437 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 437 aa overlap). Probable bioA,adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62). Highly similar to BIOA_MYCLE|P4548 from M. leprae (436 aa), FASTA results: opt: 2534, E(): 0, (85.1% identity in 436 aa overlap). Also similar to other M. tuberculosis proteins e.g. MTCY227.12c (449 aa), FASTA score: E(): 3.5e-16, (29.5% identity in 421 aa overlap). Contains aminotransferases class-III pyridoxal-phosphate attachment site (PS00600). BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. X2BIJ6,P0A4X7 No intermediary metabolism and respiration Rv1568 NC_002945.3 Mycobrowser_v2 CDS 1762068 1763228 . + 0 Mb1596 bioF1 PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF1 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE) Mb1596, bioF1, len: 386 aa. Equivalent to Rv1569,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 386 aa overlap). Probable bioF1,8-amino-7-oxononanoate synthase (EC 2.3.1.47), highly similar to BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa), FASTA results: opt: 1971, E(): 0, (80.1% identity in 381 aa overlap). Also similar to BIOF2|Rv0032|MTCY10H4.32 POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE from Mycobacterium tuberculosis (771 aa), FASTA score: E(): 5.5e-29, (37.4% identity in 393 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. X2BI87,P0A4X5 No NC_002945.3 Mycobrowser_v2 CDS 1763905 1764414 . + 0 Mb1598 conserved protein Mb1598, -, len: 169 aa. Equivalent to Rv1571, len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 169 aa overlap). Conserved hypothetical protein, similar at N-terminal region to Q49625|LEPB1170_C3_227 hypothetical protein from Mycobacterium leprae (104 aa), FASTA results: opt: 473,E(): 3.9e-24, (74.5% identity in 102 aa overlap). Identical to O06619|AF041819|AF041819_6 Mycobacterium bovis BCG (169 aa). Q7TZW7 No conserved hypotheticals Rv1571 NC_002945.3 Mycobrowser_v2 CDS 1764560 1764664 . - 0 Mb1598A CONSERVED HYPOTHETICAL PROTEIN Mb1598A, -, len: 34 aa. Equivalent to Rv1572c (MTCY336.31B), len: 34 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 34 aa overlap). Partial ORF, part of REP13E12 repeat element; 3' end of Rv1613c (Rv1587c) (MTCY336.17) after phage-like element (see citation below). Similar to C-terminal ends of other REP13E12 repeat elements e.g. Rv1148, Rv1945, Rv3467, etc. Length extended since first submission (+7 aa). Q7TZW6 No insertion seqs and phages Rv1572c NC_002945.3 Mycobrowser_v2 CDS 1764680 1765090 . + 0 Mb1599 Probable phiRV1 phage protein Mb1599, -, len: 136 aa. Equivalent to Rv1573, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Probable phiRv1 phage protein (see citation below). Q7VEY3 No insertion seqs and phages Rv1573 NC_002945.3 Mycobrowser_v2 CDS 1765296 1765607 . + 0 Mb1600 Probable phiRV1 phage related protein Mb1600, -, len: 103 aa. Equivalent to Rv1574, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 103 aa overlap). Probable phiRV1 phage related protein (see citation below); some similarity to Rv1575|MTCY441.17, E() 1.5e-06; and Rv2647|MTCY336.29c phiRV2 phage protein, E(): 3.5e-05. Belongs to phage phiRv1 proteins. Helix turn helix motif present at aa 14-35 (+3.61 SD). Q7VEY2 No insertion seqs and phages Rv1574 NC_002945.3 Mycobrowser_v2 CDS 1775650 1776699 . + 0 Mb1615 bioB probable biotin synthetase biob Mb1615, bioB, len: 349 aa. Equivalent to Rv1589,len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 349 aa overlap). bioB, biotin synthetase (EC 2.8.1.-) O06601. Highly similar to BIOB_MYCLE|P46715 BioB from Mycobacterium leprae (345 aa), FASTA results: opt: 1982, E(): 0, (86.5% identity in 349 aa overlap). X2BIA2,P0A507 No intermediary metabolism and respiration Rv1589 NC_002945.3 Mycobrowser_v2 CDS 1765712 1766065 . + 0 Mb1601 Probable phiRV1 phage protein Mb1601, -, len: 117 aa. Similar to Rv1575 and Rv1575A, len: 117 aa and 65 aa, from Mycobacterium tuberculosis strain H37Rv, (66.9% identity in 124 aa overlap). Probable phiRV1 phage protein (see citation below). Similarity in N-terminal part to Rv1574|MTCY336.30c (103 aa), FASTA score: E(): 0.00022,(44.0% identity in 50 aa overlap); and Rv2647 phiRV2 phage protein. Similarity suggests should continue as Rv1575A. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1575 and Rv1575A exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base deletion (c-*) and a single base insertion (*-g) lead to a single product. Q7VEY1 No NC_002945.3 Mycobrowser_v2 CDS 1771673 1771894 . - 0 Mb1610c Possible phiRv1 phage protein Mb1610c, -, len: 73 aa. Equivalent to Rv1584c, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 73 aa overlap). Possible phiRv1 phage protein (putative excisionase) (see citation below). Q7VEX2 No insertion seqs and phages Rv1584c NC_002945.3 Mycobrowser_v2 CDS 1767438 1767950 . - 0 Mb1603c Probable phiRv1 phage protein Mb1603c, -, len: 170 aa. Equivalent to Rv1577c,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 170 aa overlap). Probable phiRv1 phage protein (prohead protease) (see citation below). Highly similar to hypothetical protein Rv2651c|MTCY441.20c phiRV2 prohead protease, FASTA scores: E(): 0, (89.3% identity in 169 aa overlap). Some similarity to VP4_BPHK7|P49860 putative bacteriophage HK97 prohead protease (gp4) (225 aa), FASTA results: opt: 176, E(): 1.3e-05, (27.3% identity in 165 aa overlap). Q7VEX9 No insertion seqs and phages Rv1577c NC_002945.3 Mycobrowser_v2 CDS 1768124 1768594 . - 0 Mb1604c Probable phiRv1 phage protein Mb1604c, -, len: 156 aa. Equivalent to Rv1578c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 156 aa overlap). Probable phiRv1 phage protein (terminase) (see citation below), highly similar to Rv2652c|MTCY441.21c phiRV2 phage protein from M. tuberculosis, FASTA scores: E(): 4.8e-22, (48.1% identity in 156 aa overlap). Also similar to X65555|ARP3COS_1 hypothetical protein (cos site) - actinophage RP3 (210 aa), FASTA scores: opt: 373, E(): 6.5e-17, (50.0% identity in 114 aa overlap). Contains MIP family signature (PS00221). Q7VEX8 No insertion seqs and phages Rv1578c NC_002945.3 Mycobrowser_v2 CDS 1768986 1769258 . - 0 Mb1606c Probable phiRv1 phage protein Mb1606c, -, len: 90 aa. Equivalent to Rv1580c, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 90 aa overlap). Probable phiRv1 phage protein (see citation below). Q7VEX6 No insertion seqs and phages Rv1580c NC_002945.3 Mycobrowser_v2 CDS 1769272 1769667 . - 0 Mb1607c Probable phiRv1 phage protein Mb1607c, -, len: 131 aa. Equivalent to Rv1581c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 131 aa overlap). Probable phiRv1 phage protein (see citation below). Q7VEX5 No insertion seqs and phages Rv1581c NC_002945.3 Mycobrowser_v2 CDS 1776700 1776939 . + 0 Mb1616 CONSERVED HYPOTHETICAL PROTEIN Mb1616, -, len: 79 aa. Equivalent to Rv1590, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 79 aa overlap). Conserved hypothetical protein, similar to Q49616|LEPB1170_C1_162|YF90_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 368, E(): 1.7e-21, Smith-Waterman score: 368, (67.1% identity in 73 aa overlap). X2BIS6 No conserved hypotheticals Rv1590 NC_002945.3 Mycobrowser_v2 CDS 1769863 1771278 . - 0 Mb1608c Probable phiRv1 phage protein Mb1608c, -, len: 471 aa. Equivalent to Rv1582c,len: 471 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 471 aa overlap). Probable phiRv1 phage protein (see citation below). N-terminus is similar to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519 aa),FASTA scores: opt: 331, E(): 6.5e-15, (28.5% identity in 235 aa overlap); and C-terminus to whole of Q38031 ORF10 of Bacteriophage phi-C31 (202 aa), FASTA scores: opt: 353,E(): 1e-16, (31.1% identity in 190 aa overlap). Also similar to part of AB016282|AB016282_42 Bacteriophage phi-105 (806 aa), FASTA scores: opt: 790, E(): 0, (32.7% identity in 459 aa overlap). Similarity to other phage proteins described as putative DNA-polymerase or DNA-primase. Also slightly similar to MTCY441.24c, FASTA scores: E(): 0.0055, (36.0% identity in 75 aa overlap). Q7VEX4 No insertion seqs and phages Rv1582c NC_002945.3 Mycobrowser_v2 CDS 1771278 1771676 . - 0 Mb1609c Probable phiRv1 phage protein Mb1609c, -, len: 132 aa. Equivalent to Rv1583c,len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 132 aa overlap). Probable phiRv1 phage protein (see citation below), highly similar to Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA score: E(): 1.3e-33, (81.7% identity in 131 aa overlap). Q7VEX3 No insertion seqs and phages Rv1583c NC_002945.3 Mycobrowser_v2 CDS 1772462 1773871 . - 0 Mb1612c Probable phiRv1 integrase Mb1612c, -, len: 469 aa. Equivalent to Rv1586c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 469 aa overlap). Probable phiRv1 integrase, possibly member of the serine family of recombinases (see citation below), similar to several bacteriophage integrases e.g. Q37839 ORF469 PROTEIN from Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E(): 1.6e-29, (31.1% identity in 482 aa overlap); and Bacteriophage TP901-1. Q7VEX0 No insertion seqs and phages Rv1586c NC_002945.3 Mycobrowser_v2 CDS 1773528 1774529 . - 0 Mb1613c Partial REP13E12 repeat protein Mb1613c, -, len: 333 aa. Equivalent to Rv1587c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(97.2% identity in 217 aa overlap). Partial REP13E12 repeat protein (see citation below), nearly identical (but has been interrupted by phiRv1 prophage) to Q50655|MTCY251.13c HYPOTHETICAL 34.6 KD PROTEIN from M. tuberculosis (317 aa), FASTA results: opt: 2020, E(): 0,(98.0% identity in 302 aa overlap); Rv0094c|MTCY251.13c (317 aa), FASTA results: E(): 0, (100.0% identity in 217 aa overlap). Codon usage suggests that translation may involve frameshifting of Rv1588c mRNA in poly_C stretch into reading frame of Rv1587c. 3' end found in Rv1572c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587 possibly exists as a pseudogene that has been disrupted when the phage entered. Q7VEL3 No insertion seqs and phages Rv1587c NC_002945.3 Mycobrowser_v2 CDS 1774534 1775202 . - 0 Mb1614c Partial REP13E12 repeat protein Mb1614c, -, len: 222 aa. Equivalent to Rv1588c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(98.2% identity in 222 aa overlap). Partial REP13E12 repeat protein (see citation below), nearly identical to ORF's in other Rep13E12 repeats, including Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypothetical 15.4 kd protein cy251.14 from Mycobacterium tuberculosis (136 aa),FASTA results: opt: 613, E(): 9.9e-29, (86.5% identity in 111 aa overlap). X2BIL6 No insertion seqs and phages Rv1588c NC_002945.3 Mycobrowser_v2 CDS 1777766 1779106 . - 0 Mb1618c CONSERVED HYPOTHETICAL PROTEIN Mb1618c, -, len: 446 aa. Equivalent to Rv1592c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 446 aa overlap). Conserved hypothetical protein, some similarity to Q49629|B1170_F1_46 from Mycobacterium leprae (132 aa), FASTA results: opt: 332,E(): 4.5e-14, (56.3% identity in 87 aa overlap). Nearly identical to truncated Mycobacterium bovis BCG protein (148 aa) AF041819|AF041819_11. Q7TZW5 No conserved hypotheticals Rv1592c NC_002945.3 Mycobrowser_v2 CDS 1779363 1780073 . - 0 Mb1619c conserved protein Mb1619c, -, len: 236 aa. Equivalent to Rv1593c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). Conserved hypothetical protein, highly similar to Q49628|B1170_F1_44 from Mycobacterium leprae (286 aa), FASTA scores: opt: 1304, E (): 0, (85.4% identity in 233 aa overlap); similar to several putative DNA hydrolases e.g. Q9S233|SCI51.07C from Streptomyces coelicolor (239 aa), FASTA scores: opt: 415,E(): 4.6e-20, (34.8% identity in 221 aa overlap); also similar to P74291|SLR1690 hypothetical protein from synechocystis (261 aa), FASTA scores: opt: 228, E(): 1.4e-17, (31.5% identity in 213 aa overlap). TBparse score is 0.922 Q7TZW4 No conserved hypotheticals Rv1593c NC_002945.3 Mycobrowser_v2 CDS 1780122 1781171 . + 0 Mb1620 nadA Probable quinolinate synthetase nadA Mb1620, nadA, len: 349 aa. Equivalent to Rv1594,len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 349 aa overlap). Probable nadA,quinolinate synthetase. Similar to many e.g. Q49622 NADA from Mycobacterium leprae (368 aa), FASTA results: opt: 1994, E(): 0, (84.4% identity in 352 aa overlap). X2BIA6,P65498 No intermediary metabolism and respiration Rv1594 NC_002945.3 Mycobrowser_v2 CDS 1781171 1782754 . + 0 Mb1621 nadB Probable L-aspartate oxidase nadB Mb1621, nadB, len: 527 aa. Equivalent to Rv1595,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 527 aa overlap). Probable nadB,L-aspartate oxidase (EC 1.4.3.16). Similar to many e.g. Q49617 L-ASPARTATE OXIDASE (QUINOLINATE SYNTHETASE) from Mycobacterium leprae (424 aa), FASTA results: opt: 2152,E(): 0, (82.0% identity in 400 aa overlap). Also shows some similarity to Rv1552 frdA from Mycobacterium tuberculosis (583 aa), FASTA results: E(): 1e-10, (35.3% identity in 566 aa overlap). HETERODIMER. THE QUINOLINATE SYNTHETASE COMPLEX CONSISTS OF THE TWO ENZYMES QUINOLINATE SYNTHETASE A AND B. TBparse score is 0.896. X2BIT0,P65500 No intermediary metabolism and respiration Rv1595 NC_002945.3 Mycobrowser_v2 CDS 1782754 1783611 . + 0 Mb1622 nadC Probable nicotinate-nucleotide pyrophosphatase nadC Mb1622, nadC, len: 285 aa. Equivalent to Rv1596,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Probable nadC,nicotinate-nucleotide pyrophosphatase (EC 2.4.2.19) O06594. Similar to many e.g. ADC_MYCLE|P46714 from Mycobacterium leprae (284 aa), FASTA results: opt: 1418,E(): 0,(79.2% identity in 283 aa overlap). BELONGS TO THE NADC/MODD FAMILY. Q7VEW9 No intermediary metabolism and respiration Rv1596 NC_002945.3 Mycobrowser_v2 CDS 1784949 1786265 . + 0 Mb1625 hisD Probable histidinol dehydrogenase HisD (HDH) Mb1625, hisD, len: 438 aa. Equivalent to Rv1599,len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 438 aa overlap). Probable hisD,histidinol dehydrogenase (EC 1.1.1.23) (see citation below) O08396. Similar to many e.g. HISX_MYCSM|P28736 from Mycobacterium smegmatis (445 aa), FASTA results: opt: 2356, E(): 0, (83.1% identity in 437 aa overlap). Contains histidinol dehydrogenase signature (PS00611). X2BIB0,P63951 No intermediary metabolism and respiration Rv1599 NC_002945.3 Mycobrowser_v2 CDS 1786262 1787404 . + 0 Mb1626 hisC1 Probable histidinol-phosphate aminotransferase hisC1 Mb1626, hisC1, len: 380 aa. Equivalent to Rv1600,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 380 aa overlap). Probable hisC1,histidinol-phosphate aminotransferase (EC 2.6.1.9) O06591. Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces coelicolor (369 aa), FASTA results: opt: 1353, E(): 0,(59.0% identity in 356 aa overlap). Some similarity to other Mycobacterium tuberculosis aminotransferases e.g. Rv3772|MTCY13D12.06, FASTA results: E(): 7.4e-25, (33.7% identity in 365 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Note that previously known as hisC. X2BIT4,P0A679 No NC_002945.3 Mycobrowser_v2 CDS 1811364 1811951 . - 0 Mb1650c Probable conserved membrane protein Mb1650c, -, len: 195 aa. Equivalent to Rv1624c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 195 aa overlap). Probable membrane protein, first start taken. Some similarity to Rv3155 nuoK, NADH dehydrogenase chain K from Mycobacterium tuberculosis. Also similar to AAK72093.1|AF196488 hypothetical protein from Mycobacterium smegmatis (205 aa). Identities = 117/195 (60%). Q7VEW1 No cell wall and cell processes Rv1624c NC_002945.3 Mycobrowser_v2 CDS 1787401 1788033 . + 0 Mb1627 hisB Probable imidazole glycerol-phosphate dehydratase hisB Mb1627, hisB, len: 210 aa. Equivalent to Rv1601,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Probable hisB,imidazole glycerol-phosphate dehydratase (EC 4.2.1.19). Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0,(57.4% identity in 202 aa overlap). BELONGS TO THE IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE FAMILY. X2BIE6,P64369 No intermediary metabolism and respiration Rv1601 NC_002945.3 Mycobrowser_v2 CDS 1788660 1789397 . + 0 Mb1629 hisA PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE HISA Mb1629, hisA, len: 245 aa. Equivalent to Rv1603,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 245 aa overlap). Probable hisA,PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE (EC 5.3.1.16), similar to many e.g. HIS4_STRCO|P16250 phosphoribosylformimino-5-aminoimidaz from Streptomyces coelicolor (240 aa), FASTA scores: opt: 1081, E(): 0, (69.0% identity in 239 aa overlap). X2BIN3,P60579 No intermediary metabolism and respiration Rv1603 NC_002945.3 Mycobrowser_v2 CDS 1789405 1790217 . + 0 Mb1630 impA PROBABLE INOSITOL-MONOPHOSPHATASE IMPA (IMP) Mb1630, impA, len: 270 aa. Equivalent to Rv1604,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 270 aa overlap). Probable impA,inositol monophosphatase (EC 3.1.3.25), similar to many e.g. AF0059|AF005905_2 inositol monophosphate phosphatase from Mycobacterium smegmatis (276 aa), FASTA scores: opt: 1241, E(): 0, (70.5% identity in 261 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv3137 and Rv2701c. Q7TZW1 No intermediary metabolism and respiration Rv1604 NC_002945.3 Mycobrowser_v2 CDS 1790219 1791022 . + 0 Mb1631 hisF Probable cyclase hisF Mb1631, hisF, len: 267 aa. Equivalent to Rv1605,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 267 aa overlap). Probable hisF, cyclase involved in histidine biosynthetic pathway, similar to many e.g. AF0304|AF030405_1 Corynebacterium glutamicum cyclase (257 aa), FASTA scores: opt: 1201, E(): 0, (71.9% identity in 256 aa overlap). BELONGS TO THE HISA / HISF FAMILY. X2BIT7,Q7VEW8 No intermediary metabolism and respiration Rv1605 NC_002945.3 Mycobrowser_v2 CDS 1791547 1792629 . + 0 Mb1633 chaA Probable ionic transporter integral membrane protein chaA Mb1633, chaA, len: 360 aa. Equivalent to Rv1607,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable chaA, ionic transporter integral membrane protein, putative calcium/proton antiporter, similar to many e.g. P31801|CHAA_ECOLI CALCIUM/PROTON ANTIPORTER from Escherichia coli (366 aa), FASTA scores: opt: 736, E(): 0,(35.9% identity in 351 aa overlap). Equivalent to Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity in 364 aa overlap). SEEMS TO BELONG TO THE CaCA FAMILY. Q7VEW7 No cell wall and cell processes Rv1607 NC_002945.3 Mycobrowser_v2 CDS 1792664 1793128 . - 0 Mb1634c bcpB Probable peroxidoxin bcpB Mb1634c, bcpB, len: 154 aa. Equivalent to Rv1608c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Probable bcpB,peroxidoxin or bacterioferritin comigratory protein,similar to many, e.g. AE0003|ECAE000335_4 bacterioferritin comigratory protein from Escherichia coli K-12 MG1655 (156 aa), FASTA scores: opt: 329, E(): 1.2e-16, (38.2% identity in 152 aa overlap); Z97179|MLCL383_22 Mycobacterium leprae cosmid L383 (161 aa) (40.2% identity in 132 aa overlap). Also similar to Rv2428 AhpC, alkyl hydroperoxide reductase from Mycobacterium tuberculosis; and other Mycobacterium tuberculosis putative peroxidoxins Rv2521, Rv2238c,Rv1932. Q7VEW6 No NC_002945.3 Mycobrowser_v2 CDS 1793269 1794819 . + 0 Mb1635 trpE anthranilate synthase component i trpe (glutamine amidotransferase) Mb1635, trpE, len: 516 aa. Equivalent to Rv1609,len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 516 aa overlap). Probable trpE,anthranilate synthase component I (EC 4.1.3.27). FASTA best: TRPE_CLOTM|P14953 anthranilate synthase component I from Clostridium thermocellum (494 aa), E(): 0, (42.6% identity in 498 aa overlap). Some similarity to Rv2386c|MTCY253.35, E(): 6.3e-17; and Rv3215|MTCY07D11.11c, E(): 5.7e-15. BELONGS TO THE ANTHRANILATE SYNTHASE COMPONENT I FAMILY. X2BIC2,P67002 No intermediary metabolism and respiration Rv1609 NC_002945.3 Mycobrowser_v2 CDS 1794809 1795516 . + 0 Mb1636 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb1636, -, len: 235 aa. Equivalent to Rv1610, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 235 aa overlap). Possible conserved membrane protein. Equivalent to AL049913|MLCB1610_23 hypothetical protein from Mycobacterium leprae (264 aa),FASTA score: (65.8% identity in 231 aa overlap). Q7TZW0 No cell wall and cell processes Rv1610 NC_002945.3 Mycobrowser_v2 CDS 2525056 2525385 . + 0 Mb2296 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2296, -, len: 109 aa. Equivalent to Rv2273, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Probable conserved transmembrane protein, similar to Rv2272 (MTCY339.38c),(35.0% identity in 100 aa overlap). X2BKM3,P64972 No cell wall and cell processes Rv2273 NC_002945.3 Mycobrowser_v2 CDS 1860690 1867070 . + 0 Mb1689 pks7 Probable polyketide synthase pks7 Mb1689, pks7, len: 2126 aa. Equivalent to Rv1661,len: 2126 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 2126 aa overlap). Probable pks7,polyketide synthase, similar to many e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa), FASTA scores: E(): 0, (48.8% identity in 2131 aa overlap); also similar to Mycobacterium tuberculosis pks12. Contains PS00606 Beta-ketoacyl synthases active site, PS00012 Phosphopantetheine attachment site. Q7VEV1 No NC_002945.3 Mycobrowser_v2 CDS 1825938 1827608 . - 0 Mb1661c probable mannosyltransferase. probable conserved transmembrane protein. Mb1661c, -, len: 556 aa. Equivalent to Rv1635c,len: 556 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 556 aa overlap). Membrane protein equivalent to CAC31770.1|AL583921 Mycobacterium leprae membrane protein (527 aa), Identities = 332/527 (62%). Q7TZV0 No cell wall and cell processes Rv1635c NC_002945.3 Mycobrowser_v2 CDS 1795606 1796424 . + 0 Mb1637 trpC Probable indole-3-glycerol phosphate synthase trpC Mb1637, trpC, len: 272 aa. Equivalent to Rv1611,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 272 aa overlap). Probable trpC,indole-3-glycerol phosphate synthase (EC 4.1.1.48). Similar to Q55508|SLR0546 HYPOTHETICAL 33.0 KD PROTEIN from SYNECHOCYSTIS SP (295 aa), FASTA score: opt: 26, E(): 7.6e-32, (44.2% identity in 265 aa overlap); also similar to TRPC_AZOBR|P26938 indole-3-glycerol-phosphate synthaseindole-3-glycerol-phosphate synthase from Azospirillum brasilense (262 aa), FASTA score: opt: 596,E(): 4.8e-30, (43.8% identity in 258 aa overlap). Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium leprae (272 aa) (90.8% identity in 272 aa overlap). Contains indole-3-glycerol phosphate synthase signature (PS00614). BELONGS TO THE TRPC FAMILY. X2BIF5,P0A633 No intermediary metabolism and respiration Rv1611 NC_002945.3 Mycobrowser_v2 CDS 1796493 1797725 . + 0 Mb1638 trpB tryptophan synthase, beta subunit trpb Mb1638, trpB, len: 410 aa. Equivalent to Rv1612,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 410 aa overlap). Probable trpB,tryptophan synthase beta chain (EC 4.2.1.20). Equivalent to AL049913|MLCB1610_25 from Mycobacterium leprae (340 aa) (88.5% identity in 331 aa overlap). Similar to others e.g. TRPB_CAUCR|P12290 tryptophan synthase beta chain from Caulobacter crescentus (406 aa), FASTA scores: opt: 1662,E(): 0, (60.6% identity in 404 aa overlap). BELONGS TO THE TRPB FAMILY. TETRAMER OF TWO ALPHA AND TWO BETA CHAINS. X2BI05,P66985 No intermediary metabolism and respiration Rv1612 NC_002945.3 Mycobrowser_v2 CDS 1797725 1798537 . + 0 Mb1639 trpA Probable tryptophan synthase, alpha subunit trpA Mb1639, trpA, len: 270 aa. Equivalent to Rv1613,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 270 aa overlap). Probable trpA,tryptophan synthase alpha chain (EC 4.2.1.20). FASTA best: O68906|TRPA_MYCIT TRYPTOPHAN SYNTHASE ALPHA CHAIN from Mycobacterium intracellulare (271 aa), opt: 1442, E(): 0,(85.3% identity in 265 aa overlap). X2BIP3,P66981 No intermediary metabolism and respiration Rv1613 NC_002945.3 Mycobrowser_v2 CDS 1798537 1799943 . + 0 Mb1640 lgt Possible prolipoprotein diacylglyceryl transferases Lgt Mb1640, lgt, len: 468 aa. Equivalent to Rv1614,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 468 aa overlap). Possible lgt,prolipoprotein diacylglyceryl transferases (EC 2.4.99.-),similar to many prolipoprotein diacylglyceryl transferases. FASTA scores: LGT_STAAU|P52282 prolipoprotein diacylglyceryl transferase from Staphylococcus aureus subsp. (279 aa), opt: 289, E():3.6e-09, (31.5% identity in 257 aa overlap); AL096884|SC4G6_3 cosmid 4G6 from Streptomyces coelicolor (343 aa), opt: 735, E(): 4e-32, (46.5% identity in 391 aa overlap). X2BIC7,Q7VEW5 No cell wall and cell processes Rv1614 NC_002945.3 Mycobrowser_v2 CDS 1906884 1908065 . + 0 Mb1723 CONSERVED HYPOTHETICAL PROTEIN Mb1723, -, len: 393 aa. Equivalent to Rv1697, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Conserved hypothetical protein, highly similar to Q49895|MLC1351.11C|U00021 Hypothetical protein of Mycobacterium leprae from cosmid L247 (430 aa), FASTA scores: opt: 2345, E(): 0, (90.6% identity in 393 aa overlap). Q7TZS0 No conserved hypotheticals Rv1697 NC_002945.3 Mycobrowser_v2 CDS 1801049 1801447 . + 0 Mb1642 CONSERVED MEMBRANE PROTEIN Mb1642, -, len: 132 aa. Equivalent to Rv1616, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 132 aa overlap). Conserved membrane protein, with some similarity to other hypothetical proteins e.g. AL096884|SC4G6_9 from Streptomyces coelicolor cosmid 4G6 (148 aa), FASTA scores: opt: 245,E(): 1.7e-1 0, (36.7% identity in 128 aa overlap); Q55401|SLL0543 HYPOTHETICAL 16.5 KD PROTEIN from SYNECHOCYSTIS SP (148 aa), FASTA scores: opt: 225, E(): 6.5e-10, (35.9% identity in 117 aa overlap). Has cysteine cluster and contains a rubredoxin signature (PS00202). Q7TZV9 No cell wall and cell processes Rv1616 NC_002945.3 Mycobrowser_v2 CDS 1802981 1803883 . + 0 Mb1644 tesB1 Probable acyl-CoA thioesterase II tesB1 Mb1644, tesB1, len: 300 aa. Equivalent to Rv1618,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 300 aa overlap). Probable tesB1,acyl-CoA thioesterase II (EC 3.1.2.-), similar to other acyl-CoA thioesterases e.g. TESB_ECOLI|P23911 acyl-coa thioesterase II from Escherichia coli (285 aa), FASTA scores: opt: 495, E(): 2.9e-27, (32.5% identity in 283 aa overlap); etc. Also similar to Rv2605c|tesB2 from M. tuberculosis. Q7VEW2 No NC_002945.3 Mycobrowser_v2 CDS 1803941 1805395 . + 0 Mb1645 CONSERVED MEMBRANE PROTEIN Mb1645, -, len: 484 aa. Equivalent to Rv1619, len: 484 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 484 aa overlap). Conserved membrane protein. Some similarity to N-terminus of P94974|Rv1640c|MTCY06H11.04c PROBABLE LYSYL-TRNA SYNTHETASE 2 (EC 6.1.1.6) from Mycobacterium tuberculosis (1172 aa), FASTA scores: E(): 1.4e-16, (28.0% identity in 410 aa overlap); and similar in part to O69916| SC3C8.03C Putative intergral membrane protein from Streptomyces coelicolor cosmid 3C8 (589 aa), FASTA scores: opt: 453 E(): 8.4e-22, (31.3% identity in 313 aa overlap). Q7TZV8 No cell wall and cell processes Rv1619 NC_002945.3 Mycobrowser_v2 CDS 1805329 1807059 . - 0 Mb1646c cydC PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER CYDC Mb1646c, cydC, len: 576 aa. Equivalent to Rv1620c,len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 576 aa overlap). Probable cydC,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. CYDC_ECOLI|P23886 transport ATP-binding protein from Escherichia coli (573 aa), FASTA scores: opt: 631, E(): 1.6e-30, (28.5% identity in 569 aa overlap); C-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FASTA scores: opt: 956, E(): 0, (38.8% identity in 554 aa overlap); etc. Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TZV7 No NC_002945.3 Mycobrowser_v2 CDS 1832082 1832339 . - 0 Mb1665c CONSERVED HYPOTHETICAL PROTEIN Mb1665c, -, len: 85 aa. Equivalent to Rv1638A, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 85 aa overlap). Conserved hypothetical protein, similar to C-terminal part of P31511|35KD_MYCTU 35kd immunogenic protein from Mycobacterium tuberculosis (270 aa), FASTA scores: opt: 159, E(): 0.002, (50.90% identity in 55 aa overlap); and to Mycobacterium leprae ML0981 possible pseudogene, an orthologue of 35kd immunogenic protein from M. tuberculosis. Size difference suggests possible gene fragment. Q7TVB8 No conserved hypotheticals Rv1638A NC_002945.3 Mycobrowser_v2 CDS 1807056 1808639 . - 0 Mb1647c cydD PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER CYDD Mb1647c, cydD, len: 527 aa. Equivalent to Rv1621c,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 527 aa overlap). Probable cydD,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. P94366|CYDC_BACSU TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (567 aa), FASTA scores: opt: 784, E(): 0, (30.1% identity in 535 aa overlap); N-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa),FASTA scores: opt: 1295, E(): 0, (44.6% identity in 534 aa overlap); etc. Also similar to Q11019|Y07D_MYCTU from Mycobacterium tuberculosis (579 aa), FASTA scores: opt: 530, E(): 6.9e-25, (29.1% identity in 530 aa overlap). Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TZV6 No NC_002945.3 Mycobrowser_v2 CDS 1885637 1886371 . - 0 Mb1702c cmr probable transcriptional regulatory protein cmr Mb1702c, -, len: 244 aa. Equivalent to Rv1675c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 244 aa overlap). Probable transcriptional regulatory protein, weak similarity to D00496|LBATRP_7 trp operon from Lactobacillus casei (219 aa), FASTA scores: opt: 172, E(): 0.00011, (26.9% identity in 186 aa overlap). Q7TZT5 No regulatory proteins Rv1675c NC_002945.3 Mycobrowser_v2 CDS 1808726 1809766 . - 0 Mb1648c cydB Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB (Cytochrome BD-I oxidase subunit II) Mb1648c, cydB, len: 346 aa. Equivalent to Rv1622c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 346 aa overlap). Probable cydB,cytochrome D ubiquinol oxidase subunit II (EC 1.10.3.-),integral membrane protein, similar to others e.g. P11027|CYDB_ECOLI CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II from Escherichia coli strain K12 (379 aa), FASTA scores: opt: 519, E(): 0, (32.3% identity in 372 aa overlap); P94365|CYDB_BACSU CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II from Bacillus subtilis (338 aa), FASTA scores: opt: 824, E(): 0, (39.5% identity in 337 aa overlap); etc. Q7TZV5 No NC_002945.3 Mycobrowser_v2 CDS 1809796 1811253 . - 0 Mb1649c cydA Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA (Cytochrome BD-I oxidase subunit I) Mb1649c, cydA, len: 485 aa. Equivalent to Rv1623c,len: 485 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 485 aa overlap). Probable cydA (previously known as appC, but renamed cydA to conform with Mycobacterium smegmatis nomenclature), cytochrome D ubiquinol oxidase subunit I (EC 1.10.3.-), integral membrane protein, similar to others e.g. P26459|APPC_ECOLI|CYXA|CBDA|B0978 CYTOCHROME BD-II OXIDASE SUBUNIT I from Escherichia coli strain K12 (514 aa), FASTA scores: opt: 870, E(): 0, (35.9% identity in 485 aa overlap); AL034355|SCD78_12 from Streptomyces coelicolor (501 aa), FASTA scores: opt: 1099, E(): 0, (48.6% identity in 510 aa overlap); etc. Q7TZV4 No NC_002945.3 Mycobrowser_v2 CDS 2525442 2525759 . - 0 Mb2297c mazf8 possible toxin mazf8 Mb2297c, -, len: 105 aa. Equivalent to Rv2274c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 105 aa overlap). Unknown protein; questionable ORF Q7TYV8 No virulence, detoxification, adaptation Rv2274c NC_002945.3 Mycobrowser_v2 CDS 1811980 1813236 . - 0 Mb1651c cya MEMBRANE-ANCHORED ADENYLYL CYCLASE CYA (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) Mb1651c, cya, len: 418 aa. Equivalent to Rv1625c,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 418 aa overlap). cya, membrane-anchored adenylyl cyclase (EC 4.6.1.1) (see citations below). C-terminal half is similar to region in numerous eukaryotic adenylate and guanylate cyclases. N-terminal half hydrophobic. FASTA score: CYG2_RAT|P22717 guanylate cyclase soluble, beta-2 chain (682 aa), FASTA scores: opt: 552, E(): 2.7e-26, (40.3% identity in 226 aa overlap). Some similarity to Rv2435c|MTCY428.11 from Mycobacterium tuberculosis (730 aa), E(): 7e-19. Start changed since first submission (+25 aa). BELONGS TO ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY. X2BIV0,P0A4Y1 No NC_002945.3 Mycobrowser_v2 CDS 1813546 1814163 . + 0 Mb1652 Probable two-component system transcriptional regulator Mb1652, -, len: 205 aa. Equivalent to Rv1626, len: 205 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 205 aa overlap). Probable two-component response system transcriptional regulator, similar to many e.g. CHEY_BACSU|P24072 chemotaxis protein chey homolog (119 aa), FASTA scores: opt: 283, E(): 1.6e-16, (43.0% identity in 114 aa overlap). Also similar to AL109732|SC7H2_27 hypothetical protein from Streptomyces coelicolor (218 aa), opt: 880, E(): 0, (69.4% identity in 196 aa overlap). Q7VEW0 No regulatory proteins Rv1626 NC_002945.3 Mycobrowser_v2 CDS 1814231 1815439 . - 0 Mb1653c Probable nonspecific lipid-transfer protein Mb1653c, -, len: 402 aa. Equivalent to Rv1627c,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 402 aa overlap). Probable nonspecific lipid-transfer protein, similar to many lipid carrier proteins e.g. Q51797 ACETYL CoA SYNTHASE from Pyrococcus furiosus (388 aa), FASTA scores: opt: 400, E(): 3.2e-18,(34.4% identity in 407 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv3523,Rv3540c, Rv0244, Rv2790c, Rv1323, etc. Q7VEV9 No lipid metabolism Rv1627c NC_002945.3 Mycobrowser_v2 CDS 1816031 1818745 . + 0 Mb1655 polA probable dna polymerase i pola Mb1655, polA, len: 904 aa. Equivalent to Rv1629,len: 904 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 904 aa overlap). polA, DNA polymerase I (EC 2.7.7.7). Has DNA polymerase family A signature (PS00447) at C-terminal end. FASTA best: DPO1_MYCTU|Q07700 DNA polymerase I from Mycobacterium tuberculosis (904 aa). Some similarity to Rv2090|MTCY49.30 (393 aa), E(): 2.2e-18, (38.7% identity in 292 aa overlap). BELONGS TO DNA POLYMERASE TYPE-A FAMILY. X2BIE3,P0A551 No information pathways Rv1629 NC_002945.3 Mycobrowser_v2 CDS 1818908 1820353 . + 0 Mb1656 rpsA 30s ribosomal protein s1 rpsa Mb1656, rpsA, len: 481 aa. Equivalent to Rv1630,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 481 aa overlap). Probable rpsA,ribosomal protein S1. FASTA best: RS1_MYCLE|P46836 30s ribosomal protein S1 from Mycobacterium leprae (482 aa),opt: 2655, E(): 0, (87.2% identity in 483 aa overlap). Q7TZV2 No information pathways Rv1630 NC_002945.3 Mycobrowser_v2 CDS 1951054 1951338 . + 0 Mb1767 conserved protein Mb1767, -, len: 94 aa. Equivalent to Rv1738, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Conserved hypothetical protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kd protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap). X2BJ31 No conserved hypotheticals Rv1738 NC_002945.3 Mycobrowser_v2 CDS 1820379 1821602 . + 0 Mb1657 coaE Probable dephospho-CoA kinase coaE (dephosphocoenzyme A kinase) Mb1657, coaE, len: 407 aa. Equivalent to Rv1631,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 407 aa overlap). Probable coaE,dephospho-CoA kinase (EC 2.7.1.24), similar to many e.g. Q50178|ML1383|COAE_MYCLE DEPHOSPHO-COA KINASE from Mycobacterium leprae (410 aa), FASTA scores: E(): 0,(77.5% identity in 409 aa overlap). Has ATP/GTP-binding site motif A (P-loop, PS00017) at N-terminus. IN THE N-TERMINAL SECTION; BELONGS TO THE COAE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE UPF0157 (GRPB) FAMILY. X2BIH7,P63827 No intermediary metabolism and respiration Rv1631 NC_002945.3 Mycobrowser_v2 CDS 1821753 1822196 . - 0 Mb1658c HYPOTHETICAL PROTEIN Mb1658c, -, len: 147 aa. Equivalent to Rv1632c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 147 aa overlap). Hypothetical unknown protein. Q7TZV1 No conserved hypotheticals Rv1632c NC_002945.3 Mycobrowser_v2 CDS 1881871 1882263 . + 0 Mb1698 probable membrane protein Mb1698, -, len: 130 aa. Equivalent to Rv1671, len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 130 aa overlap). Probable membrane protein. Weak similarity to mercuric transport proteins. Q7TZT9 No cell wall and cell processes Rv1671 NC_002945.3 Mycobrowser_v2 CDS 1822441 1824537 . + 0 Mb1659 uvrB probable excinuclease abc (subunit b-helicase) uvrb Mb1659, uvrB, len: 698 aa. Equivalent to Rv1633,len: 698 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 698 aa overlap). uvrB, Excinuclease abc subunit B, has ATP/GTP-binding site motif A (P-loop; PS00017) near N-terminus. FASTA best: UVRB_MICLU|P10125 from Micrococcus luteus (709 aa), opt: 3268, E(): 0,(71.3% identity in 704 aa overlap). Also similar to M. tuberculosis Rv2973c (recG); and Rv1020 (mfd). BELONGS TO THE UVRB FAMILY. X2BIR5,P67423 No information pathways Rv1633 NC_002945.3 Mycobrowser_v2 CDS 1824534 1825949 . + 0 Mb1660 Possible drug efflux membrane protein Mb1660, -, len: 471 aa. Equivalent to Rv1634, len: 471 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 471 aa overlap). Possible drug efflux membrane protein of major facilitator superfamily (MFS),similar to many antibiotic resistance (efflux) proteins. FASTA best: Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE (GRAE) from Streptomyces violaceoruber (557 aa), opt: 415, E(): 1.7e-17, (26.7% identity in 446 aa overlap). Relatives in Mycobacterium tuberculosis: MTCY369.27c, E(): 4.8e-12; MTCY20B11.14c, E(): 2.9e-10. Q7VEV8 No cell wall and cell processes Rv1634 NC_002945.3 Mycobrowser_v2 CDS 2000453 2001013 . - 0 Mb1805c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1805c, -, len: 186 aa. Equivalent to Rv1776c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Possible regulatory protein, some similarity to Mycobacterium tuberculosis Rv1255c|Q11063 hypothetical transcriptional regulator (202 aa), FASTA scores: opt: 270, E( ): 9.7e-09, (28.3% identity in 191 aa overlap) . Contains possible helix-turn-helix motif at aa 37-58 (+3.49 SD). Q7TZK2 No regulatory proteins Rv1776c NC_002945.3 Mycobrowser_v2 CDS 1827817 1828257 . + 0 Mb1662 TB15.3 iron-regulated universal stress protein family protein tb15.3 Mb1662, TB15.3, len: 146 aa. Equivalent to Rv1636,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). TB15.3, conserved hypothetical protein (see citations below), similar to other hypothetical proteins from diverse organisms e.g. Q57951|MJ0531|Y531_METJA from Methanococcus jannaschii (170 aa), FASTA scores: opt: 188, E(): 6e-06, (32.2% identity in 149 aa overlap); also P42297|YXIE_BACSU hypothetical 15.9 kd protein in bglh-wapa intergenic region precursor from Bacillus subtilis (148 aa), FASTA scores: opt: 162, E(): 0.00025, (30.8% identity in 156 aa overlap). Part of family of Mycobacterium tuberculosis hypothetical proteins (but lacks C-terminal region) including Rv2005c, Rv2623, Rv2026c, Rv1996, etc. Q7TZU9 No NC_002945.3 Mycobrowser_v2 CDS 1945252 1945884 . - 0 Mb1762c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb1762c, -, len: 210 aa. Equivalent to Rv1733c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 210 aa overlap). Probable conserved transmembrane protein. Similar to AL109962|SCJ1_26 hypothetical protein from Streptomyces coelicolor (193 aa), FASTA scores: opt: 287, E(): 3.8e-11, (35.2% identity in 182 aa overlap). Q7TZP1 No cell wall and cell processes Rv1733c NC_002945.3 Mycobrowser_v2 CDS 1828264 1829058 . - 0 Mb1663c conserved protein Mb1663c, -, len: 264 aa. Equivalent to Rv1637c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 264 aa overlap). Conserved hypothetical protein, some similarity to others e.g. P05446|GLO2_RHOBL PROBABLE HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) (255 aa), FASTA scores: opt: 252, E(): 2e-09, (39.0% identity in 146 aa overlap). Also similar to Q9Z505|AL035591|SCC54.20 putative hydrolase from Streptomyces coelicolor (218 aa), FASTA scores: opt: 732,E(): 0, (52.3% identity in 220 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins and putative glyoxylases e.g. Rv0634c, Rv3677c, Rv2581c,Rv2260. Q7TZU8 No conserved hypotheticals Rv1637c NC_002945.3 Mycobrowser_v2 CDS 2525793 2526041 . - 0 Mb2297A mazE8 Possible antitoxin MazE8 Mb2297A, len: 82 aa. Equivalent to Rv2274A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazE8,antitoxin, part of toxin-antitoxin (TA) operon with Rv2274c (See Pandey and Gerdes, 2005). X2BK86 No virulence, detoxification, adaptation Rv2274A NC_002945.3 Mycobrowser_v2 CDS 1829107 1832025 . + 0 Mb1664 uvrA probable excinuclease abc (subunit a-dna-binding atpase) uvra Mb1664, uvrA, len: 972 aa. Equivalent to Rv1638,len: 972 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 972 aa overlap). uvrA, Excinuclease ABC subunit A, similar to many e.g. UVRA_ECOLI|P07671 excinuclease abc subunit a from Escherichia coli (940 aa),FASTA scores: opt: 2573, E(): 0, (56.2% identity in 951 aa overlap). Contains 2x PS00017 ATP/GTP-binding site motif A, PS00211 ABC transporters family signature, PS00211 ABC transporters family signature. CONSISTS OF THREE SUBUNITS; UVRA, UVRB AND UVRC. BELONGS TO THE ABC TRANSPORTER FAMILY. UVRA SUBFAMILY. X2BIR9,P63381 No information pathways Rv1638 NC_002945.3 Mycobrowser_v2 CDS 1832355 1833824 . - 0 Mb1666c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1666c, -, len: 489 aa. Equivalent to Rv1639c,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 489 aa overlap). Conserved hypothetical membrane protein. Some similarity to P35866|YLI2_CORGL Hypothetical 45.7 kd protein from Corynebacterium glutamicum (426 aa), FASTA scores: opt: 511, E( ): 2.4e-23, (28.9% identity in 370 aa overlap). Contains PS00904 protein phenyltransferases alpha subunit repeat signature. Q7TZU7 No cell wall and cell processes Rv1639c NC_002945.3 Mycobrowser_v2 CDS 1833883 1837401 . - 0 Mb1667c lysX lysyl-trna synthetase 2 lysx Mb1667c, lysX, len: 1172 aa. Equivalent to Rv1640c,len: 1172 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1172 aa overlap). Probable two domain protein, possible lysyl-tRNA synthetase 2 (EC 6.1.1.6). N-terminal part (bases 1850153 to 1852033) is similar to AL023861|SC3C8_3 hypothetical membrane protein from Streptomyces coelicolor (589 aa), Fasta scores: opt: 1426, E(): 0, (44.6% identity in 585 aa overlap). The C-terminal part is similar to SYK_CRILO|P37879 lysyl-tRNA synthetases (EC 6.1.1.6) from Cricetulus longicaudatus (Long-tailed hamster) (597 aa), Fasta scores, opt: 985,E(): 0, (36.8% identity in 524 aa overlap ). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1, PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. This may indicate a frame shift but sequence has been checked and no error found. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. X2BII9,Q7VEV7 No NC_002945.3 Mycobrowser_v2 CDS 1837638 1838243 . + 0 Mb1668 infC PROBABLE INITIATION FACTOR IF-3 INFC Mb1668, infC, len: 201 aa. Equivalent to Rv1641,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Probable infC,initiation factor IF-3, similar to many e.g. IF3_BACST|P03000 initiation factor IF-3 from Bacillus stearothermophilus (171 aa), FASTA scores: opt: 560, E(): 1.9e-27, (50.6% identity in 166 aa overlap). Note that an AUC initiation codon has been used, the Bacillus (IF3_BACSU) and Escherichia coli (IF3_ECOLI) proteins use an AUU initiation codon, and the Myxococcus xanthus (DSG_MYXXA) homolog uses a AUC. BELONGS TO THE IF-3 FAMILY. X2BI20,P65136 No information pathways Rv1641 NC_002945.3 Mycobrowser_v2 CDS 1838293 1838487 . + 0 Mb1669 rpmI 50S ribosomal protein L35 rpmI Mb1669, rpmI, len: 64 aa. Equivalent to Rv1642,len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 64 aa overlap). rpmI, 50S ribosomal protein L35, similar to several e.g. RL35_SYNY3|P48959 from Synechocystis sp. (67 aa), fasta scores: opt: 179,E(): 2.7e-08, (51.6% identity in 64 aa overlap). BELONGS TO THE L35P FAMILY OF RIBOSOMAL PROTEINS. X2BIS3,P66272 No information pathways Rv1642 NC_002945.3 Mycobrowser_v2 CDS 1838549 1838938 . + 0 Mb1670 rplT 50S ribosomal protein L20 rplT Mb1670, rplT, len: 129 aa. Equivalent to Rv1643,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). rplT, 50S ribosomal protein L20, similar to several e.g. RL20_ECOLI|P02421 from Escherichia coli (117 aa), FASTA scores: opt: 438,E(): 5.8e-24, (60.3% identity in 116 aa overlap). Contains PS00937 Ribosomal protein L20 signature. X2BIF3,P66106 No information pathways Rv1643 NC_002945.3 Mycobrowser_v2 CDS 1838971 1839753 . + 0 Mb1671 tsnR Possible 23S rRNA methyltransferase tsnR Mb1671, tsnR, len: 260 aa. Equivalent to Rv1644,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 260 aa overlap). Possible tsnR, 23S rRNA methyltransferase (EC 2.1.1.-), similar to several e.g. TSNR_STRLU|P52393 from Streptomyces laurentii (270 aa), FASTA scores: opt: 276, E(): 3.6e-11, (27.6% identity in 261 aa overlap). Also similar to M. tuberculosis hypothetical proteins Rv0881, Rv3579c, and Rv0380c. Q7VEV6 No information pathways Rv1644 NC_002945.3 Mycobrowser_v2 CDS 1839764 1840819 . - 0 Mb1672c CONSERVED HYPOTHETICAL PROTEIN Mb1672c, -, len: 351 aa. Equivalent to Rv1645c,len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 351 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53837|Rv0826|MTV043.18 (351 aa), FASTA scores: (57.5% identity in 299 aa overlap); Q10519|Rv2237|YM37_MYCTU (255 aa), O53682|Rv0276 (306 aa). Q7TZU6 No conserved hypotheticals Rv1645c NC_002945.3 Mycobrowser_v2 CDS 1841129 1842061 . + 0 Mb1673 PE17 pe family protein pe17 Mb1673, PE17, len: 310 aa. Equivalent to Rv1646,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 310 aa overlap). Member of the M. tuberculosis PE family of proteins, similar to many e.g. YW36_MYCTU|Q10873 hypothetical 53.7 kd protein cy39.36c (558 aa), FASTA scores, opt: 411, E(): 1.3e-15, (34.4% identity in 320 aa overlap). Q7TZU5 No PE/PPE Rv1646 NC_002945.3 Mycobrowser_v2 CDS 1842139 1843089 . + 0 Mb1674 adenylate cyclase (atp pyrophosphate-lyase) (adenylyl cyclase) Mb1674, -, len: 316 aa. Equivalent to Rv1647, len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 316 aa overlap). Conserved hypothetical protein, some similarity to other Mycobacterium tuberculosis hypothetical proteins e.g. Q11055|Rv1264|YC64_MYCTU Hypothetical 42.2 kd protein (397 aa), FASTA scores: opt: 197, E(): 9.4e-06, (27.1% identity in 181 aa overlap) and Q10400|Rv2212|YM12_MYCTU (378 aa). Q7TZU4 No intermediary metabolism and respiration Rv1647 NC_002945.3 Mycobrowser_v2 CDS 1843096 1843902 . + 0 Mb1675 Probable transmembrane protein Mb1675, -, len: 268 aa. Equivalent to Rv1648, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 268 aa overlap). Probable transmembrane protein, some similarity to Rv3434c|MTCY77.06C (237 aa),FASTA scores: E(): 0.00039, (31.4% identity in 194 aa overlap). Q7VEV5 No cell wall and cell processes Rv1648 NC_002945.3 Mycobrowser_v2 CDS 1844098 1845123 . + 0 Mb1676 pheS probable phenylalanyl-trna synthetase, alpha chain phes Mb1676, pheS, len: 341 aa. Equivalent to Rv1649,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 341 aa overlap). pheS,Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20),similar to several e.g. SYFA_ECOLI|P08312 from Escherichia coli (327 aa), FASTA scores: opt: 978, E(): 0, (46.5% identity in 331 aa overlap). Homology suggests this start site, but there is a potential rbs upstream of a gtg 30 bp upstream; contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. PHE-TRNA SYNTHETASE ALPHA CHAIN SUBFAMILY 1. X2BIW8,Q7VEV4 No information pathways Rv1649 NC_002945.3 Mycobrowser_v2 CDS 1961998 1962729 . + 0 Mb1777 unknown protein Mb1777, -, len: 243 aa. Equivalent to Rv1748, len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 243 aa overlap). Hypothetical unknown protein. Possibly exported protein, hydrophobic domain, TM helix aa 23-45. Q7TZM9 No conserved hypotheticals Rv1748 NC_002945.3 Mycobrowser_v2 CDS 1845123 1847618 . + 0 Mb1677 pheT probable phenylalanyl-trna synthetase, beta chain phet Mb1677, pheT, len: 831 aa. Equivalent to Rv1650,len: 831 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 831 aa overlap). pheT,Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20),similar to several e.g. SYFB_ECOLI|P07395 from Escherichia coli (795 aa), FASTA scores: opt: 995, E(): 0, (31.8% identity in 847 aa overlap). BELONGS TO THE PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN FAMILY - SUBFAMILY 1. X2BIJ8,Q7VEV3 No information pathways Rv1650 NC_002945.3 Mycobrowser_v2 CDS 1847712 1850768 . - 0 Mb1679c PE_PGRS30 pe-pgrs family protein pe_pgrs30 Mb1679c, PE_PGRS30, len: 1018 aa. Equivalent to Rv1651c, len: 1011 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 1018 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 1757, E(): 0, (50.8% identity in 714aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa). Q7TZU3 No NC_002945.3 Mycobrowser_v2 CDS 1850962 1852020 . + 0 Mb1680 argC probable n-acetyl-gamma-glutamyl-phoshate reductase argc Mb1680, argC, len: 352 aa. Equivalent to Rv1652,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 352 aa overlap). Probable argC,N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38),similar to many e.g. ARGC_STRCL|P54896 from Streptomyces clavuligerus (340 aa) , FASTA scores: opt: 1119, E(): 0,(56.9% identity in 350 aa overlap); etc. BELONGS TO THE NAGSA DEHYDROGENASE FAMILY. X2BIT1,P63563 No intermediary metabolism and respiration Rv1652 NC_002945.3 Mycobrowser_v2 CDS 1852017 1853231 . + 0 Mb1681 argJ Probable Glutamate n-acetyltransferase argJ Mb1681, argJ, len: 404 aa. Equivalent to Rv1653,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 404 aa overlap). Probable argJ,Glutamate n-acetyltransferase (EC 2.3.1.35), similar to ARGJ_BACSU|P36843 from Bacillus subtilis (406 aa), fasta scores: opt: 727, E(): 0, (36.3% identity in 410 a a overlap). X2BIF9,P63572 No intermediary metabolism and respiration Rv1653 NC_002945.3 Mycobrowser_v2 CDS 1853228 1854112 . + 0 Mb1682 argB Probable Acetylglutamate kinase argB Mb1682, argB, len: 294 aa. Equivalent to Rv1654,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 294 aa overlap). Probable argB,Acetylglutamate kinase (EC 2.7.2.8), similar to ARGB_CORGL|Q59281 (294 aa), FASTA scores: opt: 1209, E(): 0, (64.4% identity in 270 aa overlap). BELONGS TO THE ACETYLGLUTAMATE KINASE FAMILY. X2BIX2,P0A4Y7 No intermediary metabolism and respiration Rv1654 NC_002945.3 Mycobrowser_v2 CDS 1854109 1855311 . + 0 Mb1683 argD Probable Acetylornithine aminotransferase argD Mb1683, argD, len: 400 aa. Equivalent to Rv1655,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 400 aa overlap). Probable argD,Acetylornithine aminotransferase (EC 2.6.1.11), similar to ARGD_ECOLI|P18335 (406 aa), FASTA scores: opt: 958, E(): 0, (38.6% identity in 404 aa overlap), contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. X2BIK4,P63569 No intermediary metabolism and respiration Rv1655 NC_002945.3 Mycobrowser_v2 CDS 1891799 1892716 . + 0 Mb1709 Probable coiled-coil structural protein Mb1709, -, len: 305 aa. Equivalent to Rv1682, len: 305 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 305 aa overlap). Probable coiled-coil structural protein, weakly similar to many paramyosins,kinesins and plectins e.g. MYSP_ONCVO|Q02171 paramyosin from onchocerca volvulus (879 aa), fasta scores: opt: 180,E():2.6e-08, (24.4% identity in 234 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical coiled-coil proteins (wag31 antigen 84) Rv2145c and Rv2927c. Q7VEU6 No conserved hypotheticals Rv1682 NC_002945.3 Mycobrowser_v2 CDS 1946171 1946413 . - 0 Mb1763c CONSERVED HYPOTHETICAL PROTEIN Mb1763c, -, len: 80 aa. Equivalent to Rv1734c, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 80 aa overlap). Conserved hypothetical protein, similar to C-terminal region Q9Z8N2|CP0452|AE001615 Dihydrolipoamide Acetyltransferase from Chlamydia pneumoniae (429 aa), FASTA scores: opt: 138, E(): 0.0012, (26.9% identity in 78 aa overlap). Q7TZP0 No conserved hypotheticals Rv1734c NC_002945.3 Mycobrowser_v2 CDS 1855308 1856231 . + 0 Mb1684 argF Probable Ornithine carbamoyltransferase,anabolic ArgF Mb1684, argF, len: 307 aa. Equivalent to Rv1656,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Probable argF,ornithine carbamoyltransferase, anabolic (EC 2.1.3.3) (see citation below), almost identical to OTCA_MYCBO|Q02095 ornithine carbamoyltransferase, anabolic from Mycobacterium bovis (307 aa), FASTA scores: opt: 1980,E(): 0, (99.0% identity in 307 aa overlap); contains PS00097 Aspartate and ornithine carbamoyltransferases signature. BELONGS TO THE ATCASES/OTCASES FAMILY. X2BI29,P0A5M9 No intermediary metabolism and respiration Rv1656 NC_002945.3 Mycobrowser_v2 CDS 1856228 1856740 . + 0 Mb1685 argR Probable Arginine repressor argR (AHRC) Mb1685, argR, len: 170 aa. Equivalent to Rv1657,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 170 aa overlap). Probable argR, Arginine repressor (alternate gene name: ahrC). Similar to AHRC_BACSU|P17893 arginine hydroximate resistance protein from Bacillus subtilis (149 aa), FASTA scores: opt: 283,E(): 1.8e-11, (34.5% identity in 142 aa overlap); and ARGR_ECOLI|P15282 arginine repressor from Escherichia coli ( 156 aa), FASTA scores: opt: 194, E(): 6.4e-06, (30.8% identity in 146 aa overlap). BELONGS TO THE ARGR FAMILY. X2BIT5,P0A4Y9 No regulatory proteins Rv1657 NC_002945.3 Mycobrowser_v2 CDS 1856749 1857945 . + 0 Mb1686 argG Probable Argininosuccinate synthase argG Mb1686, argG, len: 398 aa. Equivalent to Rv1658,len: 398 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 398 aa overlap). Probable argG,Argininosuccinate synthase (EC 6.3.4.5), similar to ASSY_STRCL|P50986 argininosuccinate synthase from Streptomyces clavuligerus (397 aa), FASTA scores: opt: 1873, E(): 0, (67.8% identity in 397 aa overlap); contains PS00564 Argininosuccinate synthase signature 1, PS00565 Argininosuccinate synthase signature 2. BELONGS TO THE ARGININOSUCCINATE SYNTHASE FAMILY. X2BIG1,P63643 No intermediary metabolism and respiration Rv1658 NC_002945.3 Mycobrowser_v2 CDS 1858025 1859437 . + 0 Mb1687 argH Probable Argininosuccinate lyase argH Mb1687, argH, len: 470 aa. Equivalent to Rv1659,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 470 aa overlap). Probable argH,argininosuccinate lyase (EC 4.3.2.1), similar to ARLY_ECOLI|P11447 argininosuccinate lyase from Escherichia coli (457 aa), FASTA scores: opt: 1091, E(): 0, (42.5% identity in 461 aa overlap); contains PS00017 ATP/GTP-binding site motif A, PS00163 Fumarate lyases signature. BELONGS TO THE LYASE 1 FAMILY. ARGININOSUCCINATE LYASE SUBFAMILY. X2BIX5,P0A4Z1 No intermediary metabolism and respiration Rv1659 NC_002945.3 Mycobrowser_v2 CDS 1859546 1860607 . + 0 Mb1688 pks10 chalcone synthase pks10 Mb1688, pks10, len: 353 aa. Equivalent to Rv1660,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 353 aa overlap). Possible pks10,chalcone synthase (EC 2.3.1.74), similar to BCSA_BACSU|P54157 putative chalcone synthase from B. subtilis (365 aa), FASTA scores: opt: 701, E(): 0, (33.1% identity in 362 aa overlap). Also similar to M. tuberculosis Rv1665|pks11 polyketide synthase (chalcone synthase); and Rv1372|pks18 polyketide synthase. Other upstream initiation sites are possible but homology suggests this start. X2BIL0,Q7VEV2 No NC_002945.3 Mycobrowser_v2 CDS 1867090 1871898 . + 0 Mb1690 pks8 Probable polyketide synthase pks8 Mb1690, pks8, len: 1602 aa. Equivalent to Rv1662,len: 1602 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1602 aa overlap). Probable pks8,polyketide synthase, similar to many polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa), FASTA scores: opt: 3319, E(): 0,(45.8% identity in 1619 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks12. Contains PS00606 Beta-ketoacyl synthases active site and PS01162 Quinone oxidoreductase/zeta-crystallin signature. Note that the similarity extends into the downstream ORF Rv1663 (MTCY275.02), and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found. Q7VEV0 No NC_002945.3 Mycobrowser_v2 CDS 1962726 1963283 . - 0 Mb1778c POSSIBLE INTEGRAL MEMBRANE PROTEIN Mb1778c, -, len: 185 aa. Equivalent to Rv1749c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 185 aa overlap). Possible integral membrane protein, similar to O27914|AE000940 hypothetical protein MTH1892 from Methanobacterium thermoautotrophicum (168 aa), fasta scores: E(): 9.3e-16, (37.4% identity in 123 aa overlap). Q7TZM8 No cell wall and cell processes Rv1749c NC_002945.3 Mycobrowser_v2 CDS 1890646 1891638 . + 0 Mb1708 moeX POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEX Mb1708, moeX, len: 330 aa. Equivalent to Rv1681,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 330 aa overlap). Possible moeX,Molybdopterin biosynthesis protein, has weak similarity to MOAA_ECOLI|P30745 molybdenum cofactor biosynthesis protein (329 aa), FASTA scores: opt: 162, E(): 0.00081, (27.7% identity in 224 aa overlap) and to Rv3109|MTCY164.19 MoaA from Mycobacterium tuberculosis (28.5% identity in 165 aa overlap). Q7TZS9 No intermediary metabolism and respiration Rv1681 NC_002945.3 Mycobrowser_v2 CDS 1871898 1873406 . + 0 Mb1691 pks17 Probable polyketide synthase pks17 Mb1691, pks17, len: 502 aa. Equivalent to Rv1663,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 502 aa overlap). Probable pks17,polyketide synthase, similar to other polyketide synthases e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa) from Saccharopolyspora erythraea (Streptomyces erythraeus), FASTA scores: opt: 1207, E(): 0, (43.9% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks1. Note that the similarity extends into the upstream ORF Rv1662 (MTCY275.01) and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found. Contains PS00012 Phosphopantetheine attachment site. Q7VEU9 No NC_002945.3 Mycobrowser_v2 CDS 1873412 1876465 . + 0 Mb1692 pks9 Probable polyketide synthase pks9 Mb1692, pks9, len: 1017 aa. Equivalent to Rv1664,len: 1017 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1017 aa overlap). Probable pks9,polyketide synthase, similar to OL56_STRAT|Q07017 oleandomycin polyketide synthase, modules 5 and 6 from Streptomyces antibioticus (3519 aa), FASTA scores: opt: 1767, E(): 0, (41.6% identity in 919 aa overlap). Similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks6, pks8, etc. Contains PS00012 Phosphopantetheine attachment site. Q7VEU8 No NC_002945.3 Mycobrowser_v2 CDS 1876612 1877673 . + 0 Mb1693 pks11 chalcone synthase pks11 Mb1693, pks11, len: 353 aa. Equivalent to Rv1665,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 353 aa overlap). Probable pks11,chalcone synthase (EC 2.3.1.74), some similarity to BCSA_BACSU|P54157 putative chalcone synthase from Bacillus subtilis (365 aa), FASTA scores: opt: 615, E(): 6.2e-32,(33.4% identity in 308 aa overlap); and to many plant chalcone synthases e.g. CHS_VIGUN|P51089 chalcone synthase (EC 2.3.1.74) (388 aa), FASTA scores: opt: 391, E(): 7.8e-18, (27.2% identity in 349 aa overlap). Highly similar to upstream ORF Rv1660|MTCY06H11.25 pks10 (72.7% identity in 308 aa overlap); and Rv1372 pks18. X2BIL5,Q7VEU7 No NC_002945.3 Mycobrowser_v2 CDS 1877656 1878948 . - 0 Mb1694c cyp139 Probable cytochrome P450 139 CYP139 Mb1694c, cyp139, len: 430 aa. Equivalent to Rv1666c, len: 430 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 430 aa overlap). Probable cyp139, cytochrome P450 (EC 1.14.-.-), similar to many e.g. U38537|APU38537_7 from Anabaena sp. (459 aa), FASTA scores: opt: 516, E(): 1.7e-26, (25.8% identity in 418 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BI36,P63720 No intermediary metabolism and respiration Rv1666c NC_002945.3 Mycobrowser_v2 CDS 1888695 1889816 . + 0 Mb1706 fadE16 POSSIBLE ACYL-COA DEHYDROGENASE FADE16 Mb1706, fadE16, len: 373 aa. Equivalent to Rv1679,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 373 aa overlap). Possible fadE16,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to acyl/butyryl-CoA dehydrogenases e.g. NP_244665.1|NC_002570 acyl-CoA dehydrogenase from Bacillus halodurans (380 aa); NP_000008.1|NM_000017 acyl-Coenzyme A dehydrogenase from Homo sapiens (412 aa); Z99113|BSUB0010_119 from Bacillus subtilis (380 aa), FASTA scores: opt: 439, E(): 3.4e-20,(29.6% identity in 287 aa overlap); etc. Weakly similar to many dehydrogenases and to P31571|CAIA_ECOLI probable carnitine operon oxidoreductase from Escherichia coli (380 aa), FASTA scores: opt: 109, E(): 0.0066, (28.6% identity in 98 aa overlap). Q7TZT1 No NC_002945.3 Mycobrowser_v2 CDS 1889825 1890649 . + 0 Mb1707 HYPOTHETICAL PROTEIN Mb1707, -, len: 274 aa. Equivalent to Rv1680, len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 274 aa overlap). Hypothetical unknown protein. Q7TZT0 No conserved hypotheticals Rv1680 NC_002945.3 Mycobrowser_v2 CDS 1878963 1880738 . - 0 Mb1695c probable second part of macrolide-transport atp-binding protein abc transporter Mb1695c, -, len: 591 aa. Equivalent to Rv1668c and Rv1667c, len: 372 aa and 217 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 347 aa overlap and 100% identity in 217 aa overlap). Macrolide-transport ATP-binding protein ABC transporter (see citation below), similar to many ATP-binding proteins ABC transporter e.g. X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX gene (481 aa), FASTA scores: opt: 938, E(): 0, (45.6% identity in 353 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no error found, also same sequence in Mycobacterium tuberculosis CSU93 and Mycobacterium bovis. Contains PS00211 ABC transporters family signature and two times PS00017 ATP/GTP-binding site motif A. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis, a 10 bp insertion (*-tcttgccgcg) leads to a single product. Q7TZU2 No cell wall and cell processes Rv1668c NC_002945.3 Mycobrowser_v2 CDS 1881516 1881863 . + 0 Mb1697 CONSERVED HYPOTHETICAL PROTEIN Mb1697, -, len: 115 aa. Equivalent to Rv1670, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Conserved hypothetical protein, highly similar to D90908|D90908_87 Hypothetical protein of Synechocystis sp. PCC6803 complete (94 aa),FASTA scores opt: 378, E(): 3.5e-2, (55.2% identity in 96 aa overlap); also shows some similarity to M.tuberculosis hypothetical proteins e.g. C-terminal region of O53404|Rv1056 (254 aa), and P96817|Rv0140 (126 aa). Q7TZU0 No conserved hypotheticals Rv1670 NC_002945.3 Mycobrowser_v2 CDS 1882272 1883603 . - 0 Mb1699c PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Mb1699c, -, len: 443 aa. Equivalent to Rv1672c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 443 aa overlap). Probable conserved integral membrane transport protein, major facilitator superfamily, similar to several phthalate transporters or tartrate transporters e.g. U25634|AVU25634_2 Agrobacterium vitis plasmid pTrAB (433 aa), FASTA scores: opt: 914, E(): 0, (37.1% identity in 426 aa overlap); etc. Q7TZT8 No cell wall and cell processes Rv1672c NC_002945.3 Mycobrowser_v2 CDS 1883696 1884628 . - 0 Mb1700c CONSERVED HYPOTHETICAL PROTEIN Mb1700c, -, len: 310 aa. Equivalent to Rv1673c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 310 aa overlap). Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap). Q7TZT7 No conserved hypotheticals Rv1673c NC_002945.3 Mycobrowser_v2 CDS 1884656 1885312 . - 0 Mb1701c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1701c, -, len: 218 aa. Equivalent to Rv1674c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 218 aa overlap). Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa),FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. Q7TZT6 No regulatory proteins Rv1674c NC_002945.3 Mycobrowser_v2 CDS 1887144 1887692 . + 0 Mb1704 dsbF PROBABLE CONSERVED LIPOPROTEIN DSBF Mb1704, dsbF, len: 182 aa. Equivalent to Rv1677,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 182 aa overlap). Probable dsbF,conserved lipoprotein possibly involved in thiol:disulfide interchange. Highly similar to C-terminus of Z74024|MTCY274.09 mpt53 soluble secreted antigen precursor from Mycobacterium tuberculosis (173 aa), FASTA scores: opt: 482, E(): 3.6e-23, (52.8% identity in 142 aa overlap) . Also some similarity to P52237|TIPB_PSEFL THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR from Pseudomonas fluorescens (178 aa), FASTA scores: opt: 190,E(): 4.4e-05, (28.5% identity in 151 aa overlap); and P33926|DSBE_ECOLI THIOL:DISULFIDE INTERCHANGE PROTEIN from Escherichia coli (185 aa), FASTA scores: opt: 194, E(): 2.6e-05, (29.1% identity in 175 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00194 Thioredoxin family active site. Q7TZT3 No cell wall and cell processes Rv1677 NC_002945.3 Mycobrowser_v2 CDS 1892934 1895933 . + 0 Mb1710 possible bifunctional enzyme; long-chain acyl-coa synthase and lipase. Mb1710, -, len: 999 aa. Equivalent to Rv1683, len: 999 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 999 aa overlap). Possible long-chain acyl-CoA synthase. Equivalent to Z95117|MLCB1351_21 possible long-chain acyl-CoA synthase from Mycobacterium leprae (1002 aa) (85.6% identity in 1002 aa overlap). Weakly similar to FATP_MOUSE|Q60714 long-chain fatty acid transport protein (646 aa), fasta scores: opt: 331, E(): 5e-08, (24.8% identity in 630 aa overlap). Also similar to O35488|AF033031 Mouse VERY-LONG-CHAIN ACYL-COA SYNTHETASE (620 aa), fasta scores: opt: 435, E(): 2.2e-12, (24.8% identity in 545 aa overlap). Weakly similar to M. tuberculosis protein MTCI364.18 (27.4% identity in 583 aa overlap) . Contains PS00120 Lipases, serine active site. Q7VEU5 No lipid metabolism Rv1683 NC_002945.3 Mycobrowser_v2 CDS 1896116 1896739 . - 0 Mb1711c CONSERVED HYPOTHETICAL PROTEIN Mb1711c, -, len: 207 aa. Equivalent to Rv1685c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 207 aa overlap). Conserved hypothetical protein, some similarity to other Mycobacterium tuberculosis hypothetical regulatory proteins e.g. Q10774|Rv1556|YF56_MYCTU (202 aa), FASTA scores: opt: 111,E(): 1.7e-05, (24.1% identity in 195 aa overlap); and P95215|Rv0258c|MTCY06A4.02c (151 aa) FASTA scores: (32.9% identity in 140 aa overlap); also similar to Q9X8G9|SCE7.13C|AL049819 putative Streptomyces coelicolor transcriptional regulator (204 aa), FASTA scores: opt: 480, E(): 6.4e-25, (40.4% identity in 203 aa overlap). Q7TZS7 No conserved hypotheticals Rv1685c NC_002945.3 Mycobrowser_v2 CDS 1896741 1897421 . - 0 Mb1712c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER Mb1712c, -, len: 226 aa. Equivalent to Rv1686c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Probable conserved integral membrane protein ABC transporter (see citation below), similar to AL049819|SCE7.05 putative integral membrane protein from Streptomyces coelicolor (266 aa),FASTA sacores: opt: 661, E(): 0, (45.1% identity in 226 aa overlap); and Q53627|U43537 MEMBRANE PROTEIN INVOLVED IN MITHRAMYCIN RESISTANCE from STREPTOMYCES ARGILLACEUS (233 aa), FASTA scores: opt: 222, E(): 5.4e-10, (28.7% identity in 216 aa overlap). Q7TZS6 No cell wall and cell processes Rv1686c NC_002945.3 Mycobrowser_v2 CDS 1897493 1898260 . - 0 Mb1713c PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER Mb1713c, -, len: 255 aa. Equivalent to Rv1687c,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 255 aa overlap). Probable conserved ATP-binding protein ABC transporter (see citation below),similar to many ABC-type transporters e.g. P55476|NODI_RHISN nodulation ATP-binding protein I from Rhizobium sp. (343 aa), FASTA scores: opt: 479, E(): 3.7e-23, (34.6% identity in 243 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC-type transporters e.g. MTCY19H9.04 (34.5% identity in 238 aa overlap). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Also contains PS00039 DEAD-box subfamily ATP-dependent helicases signature, though this may be spurious. Q7TZS5 No cell wall and cell processes Rv1687c NC_002945.3 Mycobrowser_v2 CDS 1898319 1898930 . + 0 Mb1714 mpg possible 3-methyladenine dna glycosylase mpg Mb1714, -, len: 203 aa. Equivalent to Rv1688, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 203 aa overlap). Possible 3-methyladenine DNA glycosylase (EC 3.2.2.-), similar to several eukaryotic 3-methylpurine DNA glycosylases and 3-methyladenine DNA glycosylases e.g. Q39147|X76169 3-METHYLADENINE GLYCOSYLASE from Arabidobsis thaliana (254 aa), FASTA scores: opt: 297, E(): 8.3e-15, (31.8% identity in 198 aa overlap) and P29372|3MG_HUMAN dna-3-methyladenine glycosidase (298 aa), FASTA scores: opt: 220, E(): 7.2e-05, (36.4% identity in 184 aa overlap). BELONGS TO THE MPG FAMILY OF DNA GLYCOSYLASES. X2BIV6,P65413 No information pathways Rv1688 NC_002945.3 Mycobrowser_v2 CDS 1898942 1900216 . + 0 Mb1715 tyrS Probable Tyrosyl-tRNA synthase tyrS (TYRRS) Mb1715, tyrS, len: 424 aa. Equivalent to Rv1689,len: 424 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 424 aa overlap). Probable tyrS,Tyrosyl-tRNA synthase (EC 6.1.1.1), highly similar to many e.g. SYY_ECOLI|P00951 Escherichia coli (EC 6.1.1.1) (423 aa), FASTA scores: opt: 1271, E(): 0, (47.3% identity in 419 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. X2BII5,P67612 No information pathways Rv1689 NC_002945.3 Mycobrowser_v2 CDS 1900833 1901252 . + 0 Mb1716 lprJ PROBABLE LIPOPROTEIN LPRJ Mb1716, lprJ, len: 139 aa. Equivalent to Rv1690,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Probable lprJ,lipoprotein, contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Weakly similar to other Mycobacterium tuberculosis hypothetical proteins with conserved cysteines e.g. Rv1804c, Rv1810, Rv3354, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2 bp insertion (*-ac) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (139 aa versus 127 aa). Q7TZS4 No cell wall and cell processes Rv1690 NC_002945.3 Mycobrowser_v2 CDS 1901291 1902043 . + 0 Mb1717 CONSERVED HYPOTHETICAL PROTEIN Mb1717, -, len: 250 aa. Equivalent to Rv1691, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 250 aa overlap). Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa), FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). Q7TZS3 No conserved hypotheticals Rv1691 NC_002945.3 Mycobrowser_v2 CDS 1902040 1903101 . + 0 Mb1718 PROBABLE PHOSPHATASE Mb1718, -, len: 353 aa. Equivalent to Rv1692, len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 353 aa overlap). Probable phosphatase (EC 3.1.-.-), some similarity to others e.g. PNPP_SCHPO|Q00472 4-nitrophenylphosphatase (269 aa), FASTA scores: opt: 214, E(): 1.3e-10, (29.5% identity in 241 aa overlap); and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa), FASTA scores: opt: 314, E(): 9.8e-08, (28.2% identity in 245 aa overlap). Also similar to AL109848|SCI51.28 hypothetical protein from Streptomyces coelicolor (343 aa), FASTA scores: opt: 768,E(): 0, (44.8% identity in 315 aa overlap). Q7TZS2 No intermediary metabolism and respiration Rv1692 NC_002945.3 Mycobrowser_v2 CDS 1903098 1903274 . + 0 Mb1719 CONSERVED HYPOTHETICAL PROTEIN Mb1719, -, len: 58 aa. Equivalent to Rv1693, len: 58 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 58 aa overlap). Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. Q7TZS1 No conserved hypotheticals Rv1693 NC_002945.3 Mycobrowser_v2 CDS 1903282 1904088 . + 0 Mb1720 tlyA 2'-o-methyltransferase tlya Mb1720, tlyA, len: 268 aa. Equivalent to Rv1694,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 268 aa overlap). tlyA,cytotoxin/haemolysin homologue (see citations below),almost identical to NP_301968.1|NC_002677 cytotoxin/haemolysin homologue TlyA from Mycobacterium leprae (269 aa). TlyA homologues were also identified by PCR in M. avium, M. bovis BCG, but appeared absent in M. smegmatis, M. vaccae, M. kansasii, M. chelonae and M. phlei (see first citation below). Also highly similar to CAB83047.1|AJ271681 putative haemolysin from Mycobacterium ulcerans (281 aa); and similar to HLYA_TREHY|Q06803 pore-forming haemolysin/cytotoxin virulence determinant from Treponema hyodysenteriae (240 aa), FASTA scores: opt: 514, E():3e-30, (37.3% identity in 236 aa overlap). Q7VEU4 No virulence, detoxification, adaptation Rv1694 NC_002945.3 Mycobrowser_v2 CDS 1904088 1905011 . + 0 Mb1721 ppnK inorganic polyphosphate/atp-nad kinase ppnk (poly(p)/atp nad kinase) Mb1721, ppnK, len: 307 aa. Equivalent to Rv1695,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Probable ppnK,inorganic polyphosphate/ATP-NAD kinase (EC 2.7.1.23),equivalent to Q49897|MLC1351.13C|Z95117|PPNK_MYCLE INORGANIC POLYPHOSPHATE/ATP-NAD KINASE from Mycobacterium leprae (311 aa) (87.9% identity in 305 aa overlap). Also similar to many e.g. P37768|PPNK_ECOLI PROBABLE INORGANIC POLYPHOSPHATE/ATP-NAD KINASE (292 aa), FASTA scores: opt: 384, E(): 1.7e-23, (33.5% identity in 233 aa overlap); etc. BELONGS TO THE NAD KINASE FAMILY. X2BIZ9,P0A5S7 No intermediary metabolism and respiration Rv1695 NC_002945.3 Mycobrowser_v2 CDS 1905025 1906788 . + 0 Mb1722 recN Probable DNA repair protein recN (Recombination protein N) Mb1722, recN, len: 587 aa. Equivalent to Rv1696,len: 587 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 587 aa overlap). Probable recN, DNA repair protein, similar to many e.g. RECN_ECOLI|P05824 dna repair protein recN (553 aa), FASTA scores: opt: 508, E(): 1.9e-33, (31.5% identity in 587 aa overlap). Equivalent to Z95117|MLCB1351_12 recN from Mycobacterium leprae (587 aa), FASTA scores: (76.1% identit y in 589 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). X2BIP1,P0A5U7 No information pathways Rv1696 NC_002945.3 Mycobrowser_v2 CDS 1908087 1909031 . + 0 Mb1724 mctb outer membrane protein mctb Mb1724, -, len: 314 aa. Equivalent to Rv1698, len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 314 aa overlap). Conserved hypothetical protein, possibly exported protein with potential N-terminal signal sequence. Equivalent to Q49894|MLC1351.10C|Z95117 Hypothetical protein from Mycobacterium leprae (317 aa), FASTA scores: (77.0% identity in 317 aa overlap). Probable coiled-coil from aa 31 to 67. X2BIW3,P64884 No cell wall and cell processes Rv1698 NC_002945.3 Mycobrowser_v2 CDS 2015286 2015489 . + 0 Mb1814 probable ferredoxin Mb1814, -, len: 67 aa. Equivalent to Rv1786, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable ferredoxin (EC 1.-.-.-), similar to others e.g. X63601|FERS_STRGR FERREDOXIN from Streptomyces griseus (65 aa), FASTA scores: opt: 140, E(): 0.001, (38.1% identity in 63 aa overlap); T50943 probable ferredoxin DitA from Pseudomonas abietaniphila (78 aa); BAA84714.1|AB017795 ferredoxin from Nocardioides sp. (69 aa); etc. Also similar to Rv0763c|MTCY369.08 from Mycobacterium tuberculosis (68 aa), FASTA score: (30.6% identity in 62 aa overlap); and Rv0763c. Q7TZJ6 No intermediary metabolism and respiration Rv1786 NC_002945.3 Mycobrowser_v2 CDS 1909171 1910931 . + 0 Mb1725 pyrG probable ctp synthase pyrg Mb1725, pyrG, len: 586 aa. Equivalent to Rv1699,len: 586 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 586 aa overlap). pyrG, CTP synthase (EC 6.3.4.2) highly similar to many e.g. PYRG_ECOLI|P08398 ctp synthase from Escherichia coli (544 aa), FASTA scores: opt: 1786, E():0, (51.8% identity in 548 aa overlap). Contains PS00442 Glutamine amidotransferases class-I active site. X2BIJ7,P0A5U3 No intermediary metabolism and respiration Rv1699 NC_002945.3 Mycobrowser_v2 CDS 1910924 1911547 . + 0 Mb1726 nudix hydrolase Mb1726, -, len: 207 aa. Equivalent to Rv1700, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 207 aa overlap). Conserved hypothetical protein, equivalent to Q49891|MLC1351.08C|Z95117 Hypothetical protein from Mycobacterium leprae (177 aa),FASTA scores: (66.7% identity in 171 aa overlap); also similar to Q9S225|SCI51.15C|AL109848 Hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 508, E(): 1.2e-27, (43.1% identity in 197 aa overlap); similar to P54570|ADPP_BACSU ADP-RIBOSE PYROPHOSPHATASE (EC 3.6.1.13) (185 aa), FASTA scores: opt: 313, E(): 1.1e-06, (42.7% identity in 124 aa overlap). Q7TZR9 No information pathways Rv1700 NC_002945.3 Mycobrowser_v2 CDS 1911544 1912479 . + 0 Mb1727 PROBABLE INTEGRASE/RECOMBINASE Mb1727, -, len: 311 aa. Equivalent to Rv1701, len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 311 aa overlap). Probable integrase/recombinase, similar to many e.g. XERD_ECOLI|P21891 integrase/recombinase xerd (298 aa),FASTA scores: opt: 583, E(): 0, (41.8% identity in 311 aa overlap). Also similar to other Mycobacterium tuberculosis integrase/recombinase proteins RV2894c|MTCY274.25c (43.1% identity in 304 aa overlap); and Rv2646|MTCY441.16 phiRv2 integrase (31.1% identity in 161 aa overlap). Equivalent to Z95117|MLCB1351_7 from Mycobacterium leprae (316 aa) (85.4% identity in 316 aa overlap). X2BIP5,P67637 No insertion seqs and phages Rv1701 NC_002945.3 Mycobrowser_v2 CDS 1912553 1913917 . - 0 Mb1728c CONSERVED HYPOTHETICAL PROTEIN Mb1728c, -, len: 454 aa. Equivalent to Rv1702c,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 454 aa overlap). Conserved hypothetical ORF in REP13E12 degenerate repeat. Similar to other hypothetical proteins inside REP13E12 elements (often in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317 aa), FASTA scores: opt: 1284, E(): 0, (59.7% identity in 315 aa overlap); and Rv1128c, Rv1945, Rv1148c, etc. X2BI75 No insertion seqs and phages Rv1702c NC_002945.3 Mycobrowser_v2 CDS 1914472 1915062 . - 0 Mb1729c Probable catechol-o-methyltransferase Mb1729c, -, len: 196 aa. Equivalent to Rv1703c,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 196 aa overlap). Probable catechol-o-methyltransferase (EC 2.1.1.6), most similar to COMT_HUMAN|P21964 soluble form of mammalian catechol o-methyltransferase (271 aa), FASTA scores: opt: 405, E(): 7 .8e-29, (38.9% identity in 190 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical methyltransferases Rv0187, Rv1220c. Q7VEU3 No intermediary metabolism and respiration Rv1703c NC_002945.3 Mycobrowser_v2 CDS 1915127 1916797 . - 0 Mb1730c cycA PROBABLE D-SERINE/ALANINE/GLYCINE TRANSPORTER PROTEIN CYCA Mb1730c, cycA, len: 556 aa. Equivalent to Rv1704c,len: 556 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 556 aa overlap). Probable cycA,D-serine/D-alanine/glycine transporter, highly similar to P39312|CYCA_ECOLI d-serine/d-alanine/glycine transporter from Escherichia coli (470 aa), FASTA scores: opt: 1906,E(): 0, (59.3% identity in 459 aa overlap); etc. Also similar to other Mycobacterium tuberculosis amino-acid permeases e.g. Rv2127, Rv0346c, etc. Contains PS00218 amino acid permeases signature. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Q7TZR8 No NC_002945.3 Mycobrowser_v2 CDS 1916838 1917995 . - 0 Mb1731c PPE22 ppe family protein ppe22 Mb1731c, PPE22, len: 385 aa. Equivalent to Rv1705c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 385 aa overlap). Member of the M. tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kd protein cy274.2 3 (404 aa), fasta scores: opt: 819, E(): 0, (46.2% identity in 413 aa overlap). Q7TZR7 No NC_002945.3 Mycobrowser_v2 CDS 2209942 2210370 . + 0 Mb2009 POSSIBLE CHITINASE Mb2009, -, len: 142 aa. Equivalent to Rv1987, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Possible chitinase (EC 3.2.1.14), similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324,E(): 1.2e-14, (39.5% identity in 129 aa overlap). X2BJT8,P64906 No cell wall and cell processes Rv1987 NC_002945.3 Mycobrowser_v2 CDS 1918035 1919219 . - 0 Mb1732c PPE23 ppe family protein ppe23 Mb1732c, PPE23, len: 394 aa. Equivalent to Rv1706c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 394 aa overlap). Member of the M. tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kd protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). Q7TZR6 No NC_002945.3 Mycobrowser_v2 CDS 1919823 1919990 . - 0 Mb1733c CONSERVED HYPOTHETICAL PROTEIN Mb1733c, -, len: 55 aa. Equivalent to Rv1706A, len: 55 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 55 aa overlap). Conserved hypothetical protein, similar to part of several probable export proteins e.g. Rv0783c|Z80226_28 from Mycobacterium tuberculosis (540 aa), FASTA scores: opt: 125, E(): 0.011,(52.85% identity in 53 aa overlap). Size difference suggests possible gene fragment. Q7TZR5 No conserved hypotheticals Rv1706A NC_002945.3 Mycobrowser_v2 CDS 1928000 1928563 . + 0 Mb1742 fadB3a PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FADB3a [FIRST PART] (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) (BHBD) Mb1742, fadB3a, len: 187 aa. Equivalent to the 5' end of Rv1715, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 187 aa overlap). Probable fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa); P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b. Q7TZR0 No NC_002945.3 Mycobrowser_v2 CDS 1920223 1921683 . + 0 Mb1734 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb1734, -, len: 486 aa. Equivalent to Rv1707, len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 486 aa overlap). Probable conserved transmembrane protein, possibly involved in transport of sulfate, similar to several hypothetical proteins belonging to the sulfate permease family e.g. P40877|YCHM_ECOLI hypothetical 58.4 kd protein in pth-prsa intergenic region from Escherichia coli (550 aa), FASTA scores: opt: 486, E(): 0, (33.1% identity in 492 aa overlap). Also similar to many other Mycobacterium tuberculosis membrane proteins eg. Rv3273, Rv1739c. SEEMS TO BELONG TO THE SULP FAMILY. Q7TZR4 No cell wall and cell processes Rv1707 NC_002945.3 Mycobrowser_v2 CDS 1921701 1922657 . + 0 Mb1735 PUTATIVE INITIATION INHIBITOR PROTEIN Mb1735, -, len: 318 aa. Equivalent to Rv1708, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 318 aa overlap). Putative initiation inhibitor protein, a soj-related protein probably involved in cell process, highly similar to many sporulation initiation inhibitor proteins soj e.g. P37522|SOJ_BACSU Soj protein from Bacillus subtilis (253 aa), FASTA scores: opt: 745, E(): 0, (46.0% identity in 248 aa overlap), and more weakly to various repA/para/incC proteins from various organisms e.g. Y4CK_RHISN|P55393 putative replication protein A from Rhizobium sp. (407 aa), FASTA scores: opt: 205, E(): 4e-13, (29.0% identity in 252 aa overlap). Also similar to Mycobacterium tuberculosis hyothetical proteins Rv3213c and Rv3918c. Q7TZR3 No cell wall and cell processes Rv1708 NC_002945.3 Mycobrowser_v2 CDS 1922654 1923490 . + 0 Mb1736 scpa possible segregation and condensation protein scpa Mb1736, -, len: 278 aa. Equivalent to Rv1709, len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 278 aa overlap). Conserved hypothetical protein, similar to others e.g. P35154|YPUG_BACSU from Bacillus subtilis (251 aa), FASTA scores: opt: 271, E(): 8.2e-10, (27.0% identity in 248 aa overlap); Q9S230|SCI51.10C|AL109848 from Streptomyces coelicolor (264 aa), FASTA scores: opt: 855, E(): 0, (56.8% identity in 257 aa overlap). Equivalent to Q49888|MLC1351.05C|Z95117 from Mycobacterium leprae (268 aa), FASTA scores: (78.9% identity in 251 aa overlap). Q7TZR2 No cell wall and cell processes Rv1709 NC_002945.3 Mycobrowser_v2 CDS 1923487 1924182 . + 0 Mb1737 scpb possible segregation and condensation protein scpb Mb1737, -, len: 231 aa. Equivalent to Rv1710, len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 231 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins e.g. P35155|YPUH_BACSU from Bacillus subtilis (197 aa), FASTA scores: opt: 339, E(): 1.3e-09, (36.0% identity in 186 aa overlap); Q9S231|SCI51.09C|AL109848 from Streptomyces coelicolor (223 aa), FASTA scores: opt: 626, E(): 0,(51.0% identity in 192 aa overlap). Equivalent to O05669|MLC1351.04C|Z95117 Hypothetical protein from Mycobacterium leprae (231 aa), FASTA scores: (77.9% identity in 231 aa overlap). Q7TZR1 No cell wall and cell processes Rv1710 NC_002945.3 Mycobrowser_v2 CDS 1924179 1924943 . + 0 Mb1738 CONSERVED HYPOTHETICAL PROTEIN Mb1738, -, len: 254 aa. Equivalent to Rv1711, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 254 aa overlap). Conserved hypothetical protein, highly similar to a large family of hypothetical proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 aa), FASTA scores: opt: 496, E(): 1.1e-29, (41.6% identity in 250 aa overlap); 9S232|SCI51.08C|AL109848 PUTATIVE PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (371 aa), FASTA scores: opt: 818, E(): 0, (53.1% identity in 245 aa overlap). Equivalent to O05668|MLCB1351.03C|Z95117 Hypothetical protein from Mycobacterium leprae (256 aa),(80.5% identity in 256 aa overlap). Contains PS01149 Hypothetical yciL/yejD/yjbC family signature. X2BI85,P65843 No conserved hypotheticals Rv1711 NC_002945.3 Mycobrowser_v2 CDS 2217057 2217824 . + 0 Mb2018 unknown protein Mb2018, -, len: 255 aa. Equivalent to Rv1995, len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Hypothetical unknown protein. X2BJU3 No conserved hypotheticals Rv1995 NC_002945.3 Mycobrowser_v2 CDS 1924940 1925632 . + 0 Mb1739 cmk cytidylate kinase cmk (cmp kinase) (cytidine monophosphate kinase) (ck) Mb1739, cmk, len: 230 aa. Equivalent to Rv1712,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 230 aa overlap). Probable cmk,cytidylate kinase (EC 2.7.4.14), highly similar to many e.g. KCY_ECOLI|P23863 cytidylate kinase from Escherichia coli (227 aa), FASTA scores: opt: 534, E (): 0, (40.3% identity in 221 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Equivalent to Z95117|MLCB1351_2 from Mycobacterium leprae (223 aa) (73.5% identity in 226 aa overlap). BELONGS TO THE CYTIDYLATE KINASE FAMILY, SUBFAMILY 1. X2BIX3,P63804 No intermediary metabolism and respiration Rv1712 NC_002945.3 Mycobrowser_v2 CDS 1925629 1927020 . + 0 Mb1740 engA PROBABLE GTP-BINDING PROTEIN ENGA Mb1740, engA, len: 463 aa. Equivalent to Rv1713,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 463 aa overlap). Probable engA,GTP-binding protein. Equivalent to Q49884|MLCB1351.01|U00021_5 PROBABLE GTP-BINDING PROTEIN ENGA from Mycobacterium leprae (461 aa), (88.6% identity in 463 aa overlap). And similar to many e.g. P50743|ENGA_BACSU PROBABLE GTP-BINDING PROTEIN ENGA from Bacillus subtilus (436 aa), FASTA scores: opt: 1077, E(): 0, (40.6% identity in 434 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ERA/TRME FAMILY OF GTP-BINDING PROTEINS. ENGA SUBFAMILY. X2BIL4,P64058 No intermediary metabolism and respiration Rv1713 NC_002945.3 Mycobrowser_v2 CDS 1927194 1928006 . + 0 Mb1741 Probable oxidoreductase Mb1741, -, len: 270 aa. Equivalent to Rv1714, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 270 aa overlap). Probable oxidoreductase (EC 1.-.-.-) similar to many e.g. AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa), FASTA scores: opt: 578, E(): 3.3e-31, (38.9% identity in 265 aa overlap). Also similar to several other Mycobacterium tuberculosis oxidoreductases e.g. Rv1544, etc. Q7VEU2 No intermediary metabolism and respiration Rv1714 NC_002945.3 Mycobrowser_v2 CDS 1928621 1928914 . + 0 Mb1743 fadB3b PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FADB3b [SECOND PART] (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) (BHBD) Mb1743, fadB3b, len: 97 aa. Equivalent to the 3' end of Rv1715, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 97 aa overlap). Probable fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa); P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b. Q7TZQ9 No NC_002945.3 Mycobrowser_v2 CDS 1928917 1929747 . + 0 Mb1744 CONSERVED HYPOTHETICAL PROTEIN Mb1744, -, len: 276 aa. Equivalent to Rv1716, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 276 aa overlap). Conserved hypothetical protein, shows high similarity with AF1200|O29068|AE001021_11A conserved protein of Archaeoglobus fulgidus, gp fulgidus section 7 (278 aa),FASTA scores: E(): 0, (61.8% identity in 251 a a overlap); also weak similarity to several polyketide cyclases e.g. O68500|AF048833|DPSY from Streptomyces peucetius (272 aa),FASTA scores: opt: 194, E(): 1.7e-05, (29.6% identity in 223 aa overlap). Q7TZQ8 No conserved hypotheticals Rv1716 NC_002945.3 Mycobrowser_v2 CDS 1929747 1930097 . + 0 Mb1745 CONSERVED HYPOTHETICAL PROTEIN Mb1745, -, len: 116 aa. Equivalent to Rv1717, len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 116 aa overlap). Conserved hypothetical protein, similar to O29060|AF1208|AE001021 Hypothetical protein from Arecheoglobus fulgidus (114 aa), FASTA scores: opt: 254, E(): 3.3e-09, (37.7% identity in 114 aa overlap). Q7TZQ7 No conserved hypotheticals Rv1717 NC_002945.3 Mycobrowser_v2 CDS 1930150 1930773 . + 0 Mb1746 CONSERVED HYPOTHETICAL PROTEIN Mb1746, -, len: 207 aa. Equivalent to the 5' end of Rv1718, len: 272 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 193 aa overlap). Conserved hypothetical protein, similar to O29058|AF1210|AE001021 Hypothetical protein from Archeoglobus (313 aa), FASTA scores: opt: 301, E(): 8e-23, (31.6% identity in 301 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1718 exists as a single gene. In Mycobacterium bovis, a single base deletion (c-*) leads to a shorter product with a different COOH terminus. Q7TZQ6 No NC_002945.3 Mycobrowser_v2 CDS 1930981 1931760 . + 0 Mb1748 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1748, -, len: 259 aa. Equivalent to Rv1719, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 259 aa overlap). Probable transcriptional regulatory protein, similar to YIAJ_ECOLI|P37671 hypothetical transcriptional regulator from Escherichia coli (282 aa), FASTA scores: opt: 353,E(): 3.2e-15, (31.1% identity in 235 aa overlap). Similar to Mycobacterium tuberculosis hypothetical IclR-family transcriptional regulators Rv2989, Rv1773c. Helix-turn-helix motif from aa 34-55 (+6.94 SD). Q7TZQ5 No regulatory proteins Rv1719 NC_002945.3 Mycobrowser_v2 CDS 1933201 1934685 . + 0 Mb1751 POSSIBLE CARBOXYLASE Mb1751, -, len: 494 aa. Equivalent to Rv1722, len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 494 aa overlap). Possible carboxylases. Weak similarity to several e.g. ACCC_BACSU|P49787 biotin carboxylase from Bacillus subtilis (448 aa), fasta scores: opt: 171, E(): 0.00021, (22.8% identity in 237 aa overlap). Q7TZQ2 No lipid metabolism Rv1722 NC_002945.3 Mycobrowser_v2 CDS 2195608 2195859 . - 0 Mb1995c pard1 possible antitoxin pard1 Mb1995c, -, len: 83 aa. Equivalent to Rv1960c, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Conserved hypothetical protein, similar to O85269|AF102990|AF102990_51 hypothetical protein of Yersinia enterocolitica (80 aa),FASTA scores: opt: 149, E(): 0.00037, (42 .1% identity in 57 aa overlap). X2BJG7,P67299 No virulence, detoxification, adaptation Rv1960c NC_002945.3 Mycobrowser_v2 CDS 1934682 1935929 . + 0 Mb1752 PROBABLE HYDROLASE Mb1752, -, len: 415 aa. Equivalent to Rv1723, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). Possible hydrolase (EC 3.-.-.-), similar to others e.g. NYLB_FLASP|P07061 6-aminohexanoate-dimer hydrolase from Flavobacterium sp. (392 aa), FASTA scores: opt: 717, E(): 0, (35.1% identity in 396 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923, Rv1497, Rv2463, etc. Q7TZQ1 No intermediary metabolism and respiration Rv1723 NC_002945.3 Mycobrowser_v2 CDS 2315209 2316180 . - 0 Mb2102c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb2102c, -, len: 323 aa. Equivalent to Rv2077c,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Possible conserved transmembrane protein. Part of Mycobacterium tuberculosis protein family with Rv2542, Rv2079, Rv2797c, Rv0963c,Rv1949c. Hydrophobic stretches at C-terminus. X2BJY5,P64934 No cell wall and cell processes Rv2077c NC_002945.3 Mycobrowser_v2 CDS 1936381 1937091 . - 0 Mb1754c CONSERVED HYPOTHETICAL PROTEIN Mb1754c, -, len: 236 aa. Equivalent to Rv1725c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from BUTYRIVIBRIO FIBRISOLVENS, (108 aa), FASTA scores: opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158 aa). Q7TZP9 No conserved hypotheticals Rv1725c NC_002945.3 Mycobrowser_v2 CDS 1937192 1938577 . + 0 Mb1755 PROBABLE OXIDOREDUCTASE Mb1755, -, len: 461 aa. Equivalent to Rv1726, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 461 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt: 678, E(): 0, (29.5% identity in 465 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv3107c, Rv1257c, etc. Q7TZP8 No intermediary metabolism and respiration Rv1726 NC_002945.3 Mycobrowser_v2 CDS 1939204 1939974 . - 0 Mb1757c CONSERVED HYPOTHETICAL PROTEIN Mb1757c, -, len: 256 aa. Equivalent to Rv1728c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 256 aa overlap). Conserved hypothetical protein, some similarity to O07246|Rv0320|MTCY63.25 possible exported protein from Mycobacterium tuberculosis (220 aa), FASTA scores: E(): 1.3e-31, (42.3% identity in 220 aa overlap). C-terminal region similar to Q9ZX60|AF068845|AF068845_17 segment of gp17 of Mycobacteriophage TM4 (1229 aa), FASTA scores: opt: 385,E(): 4.3e-17, (44.6% identity in 139 aa overlap). Q7TZP6 No conserved hypotheticals Rv1728c NC_002945.3 Mycobrowser_v2 CDS 1939971 1940909 . - 0 Mb1758c possible s-adenosylmethionine-dependent methyltransferase Mb1758c, -, len: 312 aa. Equivalent to Rv1729c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 312 aa overlap). Conserved hypothetical protein, similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Q50726|Rv3399|YX99_MYCTU (348 aa), FASTA scores: opt: 1019, E(): 0, (55.7% identity in 296 aa overlap); P95074|Rv0726c (367 aa), O53795|Rv0731c (318 aa), and O53841|Rv0830 (301 aa), etc. X2BIS2,Q7TZP5 No lipid metabolism Rv1729c NC_002945.3 Mycobrowser_v2 CDS 1941089 1942642 . - 0 Mb1759c POSSIBLE PENICILLIN-BINDING PROTEIN Mb1759c, -, len: 517 aa. Equivalent to Rv1730c,len: 517 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 517 aa overlap). Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643, E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923, Rv1497, etc. Q7TZP4 No cell wall and cell processes Rv1730c NC_002945.3 Mycobrowser_v2 CDS 1951352 1953034 . - 0 Mb1768c PROBABLE SULPHATE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb1768c, -, len: 560 aa. Equivalent to Rv1739c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 560 aa overlap). Probable sulphate-transport transmembrane protein ABC transporter,similar to several e.g. P53392|G607186 high affinity sulphate transporter from Stylosanthes hamata (662 aa),FASTA scores: opt: 382, E(): 1.6e-16, (28.0% identity in 564 aa overlap); U59234.1|AAB88215.1 biotin carb. from Synechococcus sp. PCC 7942 (574 aa), FASTA scores: opt: 1838, E(): 0, (50.0% identity in 550 aa overlap); etc. Contains PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), AND SEEMS TO BELONG TO THE SULP FAMILY. Q7TZN7 No cell wall and cell processes Rv1739c NC_002945.3 Mycobrowser_v2 CDS 1943074 1944630 . + 0 Mb1760 gabD2 possible succinate-semialdehyde dehydrogenase [nadp+] dependent (ssdh) gabd2 Mb1760, gabD2, len: 518 aa. Equivalent to Rv1731,len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 518 aa overlap). Possible gabD2,succinate-semialdehyde dehydrogenase [NADP+] dependent (EC 1.2.1.16), similar to others e.g. GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from Escherichia coli (482 aa), FASTA scores: opt: 870, E(): 0, (34.7% identity in 449 aa overlap); etc. Also similar to gabD1|Rv0234c|MTCY08D5.30c PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDANT from Mycobacterium tuberculosis (511 aa); and other semialdehyde dehydrogenases e.g. Rv0768|aldA (489 aa), Rv2858c|aldC (455 aa), etc. Contains PS00216 Sugar transport proteins signature 1, PS00687 Aldehyde dehydrogenases glutamic acid active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Note that previously known as gabD1. X2BIY8,Q7TZP3 No NC_002945.3 Mycobrowser_v2 CDS 1946688 1947185 . - 0 Mb1764c HYPOTHETICAL MEMBRANE PROTEIN Mb1764c, -, len: 165 aa. Equivalent to Rv1735c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Hypothetical membrane protein, similar to part of O58614|PH0884|AP000004 Hypothetical malic acid transport protein from Pyrococcus horikoshii (330 aa), FASTA scores: opt: 167, E(): 0.0003,(29.2% identity in 120 aa overlap). Q7TZN9 No cell wall and cell processes Rv1735c NC_002945.3 Mycobrowser_v2 CDS 1947625 1949583 . - 0 Mb1765c narX Probable nitrate reductase NarX Mb1765c, narX, len: 652 aa. Equivalent to Rv1736c,len: 652 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 652 aa overlap). Probable narX, nitrate reductase (EC 1.7.99.4). Contains three domains: N-terminus (250 aa) is similar to e.g. N-terminus of NARG_ECOLI|P09152 respiratory nitrate reductase 1 alpha chain from Escherichia coli (1246 aa), FASTA scores: E(): 0, (58.6% identity in 251 aa overlap); and Rv1161|MTCI65.28|NARG PROBABLE RESPIRATORY NITRATE REDUCTASE (ALPHA CHAIN) from Mycobacterium tuberculosis (1232 aa). Central region (260-410 aa) is similar to Rv1163|O06561|NARJ PROBABLE RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) from Mycobacterium tuberculosis (201 aa),FASTA scores: E(): 0, (64.2% identity in 159 aa overlap). C-terminus (420 aa-) is similar to Rv1164|O06562|NARI PROBABLE RESPIRATORY NITRATE REDUCTASE (GAMMA CHAIN) from M. tuberculosis (246 aa), FASTA scores: E(): 0, (68.6% identity in 239 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. Q7VEU1 No NC_002945.3 Mycobrowser_v2 CDS 1949580 1950767 . - 0 Mb1766c narK2 POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 Mb1766c, narK2, len: 395 aa. Equivalent to Rv1737c,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 395 aa overlap). Possible narK2,nitrate/nitrite-transport integral membrane protein (see first citation below), possibly member of major facilitator superfamily (MFS), similar to P46907|NARK_BACSU nitrite extrusion protein from Bacillus subtilis (395 aa), FASTA scores: opt: 742, E(): 0, (33.6% identity in 375 aa overlap); and to AL109989|SCJ12.23 hypothetical nitrate/nitrite transporter from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1181, E(): 0,(49.4% identity in 389 aa overlap). Q7TZN8 No NC_002945.3 Mycobrowser_v2 CDS 1954402 1956102 . + 0 Mb1772 pknE PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE E PKNE (PROTEIN KINASE E) (STPK E) Mb1772, pknE, len: 566 aa. Equivalent to Rv1743,len: 566 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 566 aa overlap). Probable pknE,transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citation below), similar to PKN1_MYXXA|P33973 serine/threonine-protein kinase pkn1 (693 aa), fasta scores: opt: 542, E(): 1.1e-19, (35.8% identity in 302 aa overlap). Also highly similar to K08G_MYCTU|Q11053 probable serine/threonine-protein kinase (626 aa) (59.8% identity in 381 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. X2BJ35,Q7TZN3 No regulatory proteins Rv1743 NC_002945.3 Mycobrowser_v2 CDS 1956387 1956788 . - 0 Mb1773c PROBABLE MEMBRANE PROTEIN Mb1773c, -, len: 133 aa. Equivalent to Rv1744c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 133 aa overlap). Probable membrane protein, contains four imperfect 10 aa repeats, some similarity to Q25946 (MSA-2) (FRAGMENT) from Plasmodium falciparum (205 aa), FASTA scores: opt: 145, E( ): 0.048,(52.4% identity in 63 aa overlap). Q7TZN2 No cell wall and cell processes Rv1744c NC_002945.3 Mycobrowser_v2 CDS 1956859 1957389 . - 0 Mb1774c idi Probable isopentenyl-diphosphate delta-isomerase IDI (IPP isomerase) (Isopentenyl pyrophosphate isomerase) Mb1774c, idi, len: 176 aa. Equivalent to Rv1745c,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 176 aa overlap). Probable idi,isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2),similar to Q46822|ORF_O182 from Escherichia coli (182 aa),FASTA scores: opt: 465, E(): 4.7e-25, (46.9% identity in 162 aa overlap), and to IPPI_SCHPO|Q10132 isopentenyl-diphosphate delta-isomerase from Schizosaccharomyces pombe (227 aa), FASTA scores: opt: 185, E(): 5.4e-06, (30.3% identity in 152 aa overlap). BELONGS TO THE IPP ISOMERASE TYPE 1 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 3' end due to a single base tranversion (g-t), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (176 aa versus 203 aa). X2BIB8,Q7VEU0 No NC_002945.3 Mycobrowser_v2 CDS 1957536 1958966 . + 0 Mb1775 pknF ANCHORED-MEMBRANE SERINE/THREONINE-PROTEIN KINASE PKNF (PROTEIN KINASE F) (STPK F) Mb1775, pknF, len: 476 aa. Equivalent to Rv1746,len: 476 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 476 aa overlap). pknF, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to KY28_MYCTU|Q10697 probable serine/threonine-protein kinase from Mycobacterium tuberculosis (589 aa), FASTA scores: opt: 870, E(): 0, (41.6% identity in 406 aa overlap). Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. Start site chosen by homology, may extend further upstream. X2BJ00,Q7TZN1 No regulatory proteins Rv1746 NC_002945.3 Mycobrowser_v2 CDS 1959028 1961625 . + 0 Mb1776 PROBABLE CONSERVED TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER Mb1776, -, len: 865 aa. Equivalent to Rv1747, len: 865 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 865 aa overlap). Probable conserved transmembrane ATP-binding protein ABC transporter (see citation below), similar to others e.g Q55956 ABC transporter from Synechocystis sp. (790 aa), FASTA scores: opt: 738, E(): 6.3e-26, (31.6% identity in 632 aa overlap); etc. Also similar to other Mycobacterium tuberculosis ABC-type transporters e.g. Rv2397c|MTCY253.24, FASTA score: (35.2% identity in 213 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TZN0 No cell wall and cell processes Rv1747 NC_002945.3 Mycobrowser_v2 CDS 1970371 1972062 . - 0 Mb1783c conserved protein Mb1783c, -, len: 563 aa. Equivalent to Rv1754c,len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 563 aa overlap). Conserved hypothetical protein, has proline-rich central region. Some similarity in central region to other Mycobacterium tuberculosis proline-rich proteins e.g. O06555|Rv1157c|MTCI65.24c (371 aa), (32.5% identity in 191 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TZM3 No conserved hypotheticals Rv1754c NC_002945.3 Mycobrowser_v2 CDS 1963367 1964965 . - 0 Mb1779c fadD1 POSSIBLE FATTY-ACID-COA LIGASE FADD1 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb1779c, fadD1, len: 532 aa. Equivalent to Rv1750c,len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 532 aa overlap). Possible fadD1,fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to others e.g. O35488|VLCS_MOUSE VERY-LONG-CHAIN ACYL-COA SYNTHETASE from Mus musculus (620 aa); NP_113924.1|NM_031736 solute carrier family 27 (fatty acid transporter) member 2 from Rattus norvegicus (620 aa); NP_459076.1|NC_003197 crotonobetaine/carnitine-CoA ligase from Salmonella typhimurium (517 aa); CAIC_ECOLI|P31552 probable crotonobetaine/carnitine-coa ligase from Escherichia coli (522 aa), FASTA scores: opt: 448, E(): 1.9e-21, (25.1% identity in 502 aa overlap); etc. Also highly similar to fadD17|Rv3506|MTV023.13 PROBABLE FATTY-ACID-COA LIGASE from Mycobacterium tuberculosis (502 aa); and similar to others from Mycobacterium tuberculosis e.g. fadD6|MTCI364.18|Rv1206|O05307 PROBABLE FATTY-ACID-COA LIGASE (597 aa), FASTA score: (28.3% identity in 519 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7TZM7 No NC_002945.3 Mycobrowser_v2 CDS 1965019 1966401 . + 0 Mb1780 PROBABLE OXIDOREDUCTASE Mb1780, -, len: 460 aa. Equivalent to Rv1751, len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 460 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly a monooxygenase or hydroxylase, similar to MHPA_ECOLI|P77397 3-(3-hydroxy-phenyl) propionate hydroxylase (554 aa),FASTA scores: opt: 239, E(): 2e-08, (24.6% identity in 435 aa overlap); and AJ007932|SAR7932.13 oxygenase from Streptomyces argillaceus (436 aa), FASTA scores: opt: 587,E(): 8.6e-30, (32.3% identity in 359 aa overlap). Contains PS00075 Dihydrofolate reductase signature. Also similar to Mycobacterium tuberculosis hypothetical oxidoreductases Rv1260 and Rv0575c. Q7TZM6 No intermediary metabolism and respiration Rv1751 NC_002945.3 Mycobrowser_v2 CDS 1966528 1966977 . + 0 Mb1781 CONSERVED HYPOTHETICAL PROTEIN Mb1781, -, len: 149 aa. Equivalent to Rv1752, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 149 aa overlap). Conserved hypothetical protein, similar to C-terminal half of Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase (EC 1.3.1.20) from Canis familiaris (335 aa), FASTA score,opt: 168, E(): 0.00015, (31.3% identity in 112 aa overlap). Q7TZM5 No conserved hypotheticals Rv1752 NC_002945.3 Mycobrowser_v2 CDS 1980674 1983136 . - 0 Mb1789c wag22b PE-PGRS FAMILY PROTEIN WAG22B [SECOND PART] Mb1789c, wag22b, len: 820 aa. Equivalent to 3' end of Rv1759c, len: 914 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 820 aa overlap). wag22,antigen member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kd protein from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 2010, E(): 0,(53.0% identity in 724 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b. X2BID9 No NC_002945.3 Mycobrowser_v2 CDS 1967012 1970167 . - 0 Mb1782c PPE24 ppe family protein ppe24 Mb1782c, PPE24, len: 1051 aa. Similar to Rv1753c,len: 1053 aa, from Mycobacterium tuberculosis strain H37Rv, (90.7% identity in 1103 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Asn-rich proteins, similar to many e.g. YF48_MYCTU|Q10778 hypothetical protein cy48.17 (678 aa), FASTA scores: opt: 1360, E(): 0, (48.9% identity in 550 aa overlap). Note that the Gly-, Asn-rich sequence is interrupted by six near-perfect 26 aa repeats, a unique region, and another,more degenerate region of five 25 aa repeats before resuming at the C-terminus. The end of the first Gly-,Asn-rich region and the start of the first set of repeats shows some similarity to Q50577|AT10S from Mycobacterium tuberculosis (170 aa) (40.2% identity in 189 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 150 bp insertion and a 156 bp deletion, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1051 aa versus 1053 aa). Q7TZM4 No NC_002945.3 Mycobrowser_v2 CDS 2013905 2015086 . - 0 Mb1813c cyp143 PROBABLE CYTOCHROME P450 143 CYP143 Mb1813c, cyp143, len: 393 aa. Equivalent to Rv1785c, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 393 aa overlap). Probable cyp143, cytochrome P450 (1.14.-.-), similar to many e.g. AE0001|RZAE000101_4 Rhizobium sp. NGR234 (414 aa), FASTA scores: opt: 663, E(): 0, (32.4% identity in 413 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BIG2,P63724 No intermediary metabolism and respiration Rv1785c NC_002945.3 Mycobrowser_v2 CDS 1972246 1973790 . - 0 Mb1784c plcD PROBABLE PHOSPHOLIPASE C 4 PLCD Mb1784c, plcD, len: 514 aa. Equivalent to MT1799,len: 514 aa, from Mycobacterium tuberculosis strain CDC1551, (100% identity in 514 aa overlap). Probable plcD,phospholipase C 4 (EC 3.1.4.3) (see citation below),highly similar to other phospholipases e.g. Q04001|PHLA_MYCTU|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA from Mycobacterium tuberculosis (512 aa), FASTA score: opt: 2657, E(): 4.9e-156, (71.1% identity in 512 aa overlap); P95246|PHLB_MYCTU|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB from Mycobacterium tuberculosis (512 aa), FASTA score: opt: 2638, E(): 7.3e-155, (70.9% identity in 512 aa overlap); etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 region. X2BID1,P0A5R9 No NC_002945.3 Mycobrowser_v2 CDS 1973919 1975103 . - 0 Mb1785c CONSERVED HYPOTHETICAL PROTEIN Mb1785c, -, len: 394 aa. Similar to MT1800 (also known as RVD2-ORF1), len: 381 aa, from Mycobacterium tuberculosis strain CDC1551, (99.71% identity in 345 aa overlap). Conserved hypothetical protein (see citation below), showing similarity with glycosyl transferases,sulfolipid sulfoquinovosyldiacylglycerol synthases, and hypothetical proteins, e.g. Q9R6U1|SQDX SQDX PROTEIN (required for biosynthesis of the sulfolipid sulfoquinovosyldiacylglycerol) from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (377 aa), FASTA scores: opt: 348, E(): 6.7e-15, (30.40% identity in 296 aa overlap); Q8YUR9|SQDX|ALR2265 SULFOLIPID SULFOQUINOVOSYLDIACYLGLYCEROL BIOSYNTHESIS PROTEIN from Anabaena sp. strain PCC 7120 (378 aa), FASTA scores: opt: 336, E(): 4e-14, (27.832% identity in 309 aa overlap); Q9AA50|CC0756 GLYCOSYL TRANSFERASE (GROUP 1 FAMILY PROTEIN) from Caulobacter crescentus (455 aa), FASTA scores: opt: 333, E(): 7.1e-14, (29.5% identity in 315 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region. Q7TZM2 No NC_002945.3 Mycobrowser_v2 CDS 2216544 2216900 . - 0 Mb2017c cmtr metal sensor transcriptional regulator cmtr (arsr-smtb family) Mb2017c, -, len: 118 aa. Equivalent to Rv1994c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 118 aa overlap). Probable transcription regulator, similar to MERR_STRLI|P30346 probable mercury resistance operon repressor (125 aa),FASTA scores: opt: 199, E(): 3e-08, (36.3% identity in 102 aa overlap). Contains probable helix-turn-helix motif at aa 36-57 (+3.78 SD). X2BJI3,P67732 No regulatory proteins Rv1994c NC_002945.3 Mycobrowser_v2 CDS 1975253 1976392 . + 0 Mb1786 POSSIBLE SULFITE OXIDASE Mb1786, -, len: 379 aa. Equivalent to MT1801, len: 379 aa, from Mycobacterium tuberculosis strain CDC1551,(99.75% identity in 379 aa overlap). See citations below. Possible sulfite oxidase (EC 1.8.3.1), showing similarity with others e.g. P51687|SUOX_HUMAN Sulfite oxidase,mitochondrial precursor from Homo sapiens (488 aa), FASTA scores: opt: 952, E(): 6.1e-52, (43.7% identity in 357 aa overlap); Q07116|SUOX_RAT Sulfite oxidase, mitochondrial precursor from Rattus norvegicus (488 aa), FASTA scores: opt: 952, E(): 6.1e-52, (43.8% identity in 356 aa overlap); Q9VWP4|CG7280 PROBABLE SULFITE OXIDASE PRECURSOR from Drosophila melanogaster (Fruit fly) (573 aa), FASTA scores: opt: 764, E(): 4e-40, (38.4% identity in 362 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 region. Q7TZM1 No NC_002945.3 Mycobrowser_v2 CDS 1976593 1979430 . + 0 Mb1787 mmpL14 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL14 Mb1787, mmpL14, len: 945 aa. Equivalent to MT1802 (also known as RVD2-ORF3), len: 945 aa, from Mycobacterium tuberculosis strain CDC1551, (99.7% identity in 945 aa overlap). Probable mmpL14, conserved transmembrane transport protein (see citation below). Member of RND superfamily, similar to several putative transport proteins e.g. O53784|MML5_MYCTU|MMPL5|Rv0676c|MT0705|MTV040.04c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (964 aa), FASTA scores: opt: 1171, E(): 2.5e-61, (32.10% identity in 947 aa overlap); P95211|MML1_MYCTU|MMPL1|Rv0402c|MT0412|MTCY04D9.15c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (958 aa), FASTA scores: opt: 1170, E(): 2.8e-61, (33.1% identity in 940 aa overlap); etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 region. Q7TZM0 No NC_002945.3 Mycobrowser_v2 CDS 1985893 1986681 . - 0 Mb1793c unknown protein Mb1793c, -, len: 262 aa. Equivalent to Rv1762c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 262 aa overlap). Hypothetical unknown protein. Q7TZL5 No conserved hypotheticals Rv1762c NC_002945.3 Mycobrowser_v2 CDS 1979751 1980407 . + 0 Mb1788 cut1 PROBABLE CUTINASE CUT1 Mb1788, -, len: 218 aa. Similar to Rv1758, len: 174 aa, from Mycobacterium tuberculosis strain H37Rv, (98.25% identity in 172 aa overlap). Probable cut1, serine esterase, cutinase family (EC 3.1.1.-), similar to Rv2301|CUT2_MYCTU|Q50664 probable cutinase cy339.08c precursor from Mycobacterium tuberculosis (219 aa), FASTA scores: opt: 369, E(): 1. 1e-16, (39.1% identity in 179 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical cutinases Rv3452, Rv1984c, Rv3451 and Rv3724. CDS has been interrupted by IS6110 insertion element and 5'-end deleted. BELONGS TO THE CUTINASE FAMILY. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted. Q7TZL9 No NC_002945.3 Mycobrowser_v2 CDS 2195846 2196340 . + 0 Mb1996 HYPOTHETICAL PROTEIN Mb1996, -, len: 164 aa. Equivalent to Rv1961, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Hypothetical unknown protein. Q7TZ72 No conserved hypotheticals Rv1961 NC_002945.3 Mycobrowser_v2 CDS 2225748 2226500 . + 0 Mb2024 CONSERVED HYPOTHETICAL PROTEIN Mb2024, -, len: 250 aa. Equivalent to Rv2001, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0466,AL021933|MTV038_10 (264 aa), FASTA scores: opt: 592,E():0, (38.0% identity in 263 aa overlap). Q7TZ62 No conserved hypotheticals Rv2001 NC_002945.3 Mycobrowser_v2 CDS 1983133 1983417 . - 0 Mb1790c wag22a PE-PGRS FAMILY PROTEIN WAG22A [FIRST PART] Mb1790c, wag22a, len: 94 aa. Equivalent to 5' end of Rv1759c, len: 914 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 84 aa overlap). wag22,antigen member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kd protein from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 2010, E(): 0,(53.0% identity in 724 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b. Q7TZL8 No NC_002945.3 Mycobrowser_v2 CDS 1983993 1985522 . + 0 Mb1791 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb1791, -, len: 509 aa. Equivalent to the 5' end of Rv1760, len: 502 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 442 aa overlap). Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. Q10554|Y895_MYCTU|MTCY31.23 (505 aa), FASTA scores: opt: 692, E(): 0, (31.7% identity in 477 aa overlap). Member of family with at least 15 other members e.g. Rv3740c,Rv3734c, Rv1425, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7TZL7 No NC_002945.3 Mycobrowser_v2 CDS 1985510 1985893 . - 0 Mb1792c possible exported protein Mb1792c, -, len: 127 aa. Equivalent to Rv1761c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 127 aa overlap). Possibly exported protein with hydrophobic stretch or TMhelix at aa 15-37. Q7TZL6 No cell wall and cell processes Rv1761c NC_002945.3 Mycobrowser_v2 CDS 1987699 1988955 . - 0 Mb1794c CONSERVED HYPOTHETICAL PROTEIN Mb1794c, -, len: 418 aa. Equivalent to Rv1765c,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(97.8% identity in 364 aa overlap). Conserved hypothetical protein, highly similar to O53461|Rv2015c|MTV018.02c CONSERVED HYPOTHETICAL PROTEIN (418 aa), (97.8% identity in 364 aa overlap). BLAST hits with non-IS part of sequence submitted under MTU78639. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 121 bp to 848 bp substitution affects the COOH part of Mb1794c leading to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 365 aa). Q7TZL4 No conserved hypotheticals Rv1765c NC_002945.3 Mycobrowser_v2 CDS 1989582 1989797 . - 0 Mb1795c PUTATIVE TRANSPOSASE (FRAGMENT) Mb1795c, -, len: 71 aa. Equivalent to Rv1765A, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 71 aa overlap). Putative transposase (fragment), similar to part of many transposase genes including IS6110 e.g. P19774|TRA9_MYCTU PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (278 aa),FASTA scores: opt: 231, E(): 4.7e-11, (45.35% identity in 75 aa overlap). Q7TZL3 No insertion seqs and phages Rv1765A NC_002945.3 Mycobrowser_v2 CDS 2134686 2135117 . - 0 Mb1932c CONSERVED HYPOTHETICAL PROTEIN Mb1932c, -, len: 143 aa. Equivalent to Rv1897c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein. Some similarity to D63706|Q54235 ORF2 from Streptomyces griseus (149 aa), FASTA results: opt: 509, E(): 1.2e-28, (57.3% identity in 150 aa overlap); and Q45303 ORF1 PROTEIN from Corynebacterium glutamicum (144 aa), FASTA results: opt: 460, E(): 5.5e-23, (49.7% identity in 143 aa overlap). X2BJL1,P63996 No conserved hypotheticals Rv1897c NC_002945.3 Mycobrowser_v2 CDS 1990177 1990446 . + 0 Mb1795A conserved protein Mb1795A, -, len: 89 aa. Equivalent to Rv1766, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Conserved hypothetical protein, highly similar to P54431|YRKD_BACSU Hypothetical 7.0 kDa protein in bltr-spoIIIC intergenic region from Bacillus subtilis (63 aa), FASTA scores: opt: 151, E(): 1.5e-05, (53.3% identity in 45 aa overlap). Also similar to Q9RD62|SCF56.04C|AL133424 Hypothetical protein from Streptomyces coelicolor (92 aa), FASTA scores: opt: 239,E(): 1.3e-11, (62.5% identity in 64 aa overlap). Also some similarity to other Mycobacterium tuberculosis hypothetical proteins e.g. O07434|Rv0190|MTCI28.29 (96 aa), (35.5% identity in 62 aa overlap); P71543|Rv0967 (119 aa), and P71600|Rv0030 (109 aa). Start changed since original submission. Q7TZL2 No conserved hypotheticals Rv1766 NC_002945.3 Mycobrowser_v2 CDS 1991054 1992928 . + 0 Mb1797 PE_PGRS31 pe-pgrs family protein pe_pgrs31 Mb1797, PE_PGRS31, len: 624 aa. Equivalent to Rv1768, len: 618 aa, from Mycobacterium tuberculosis strain H37Rv, (98.88% identity in 624 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to Q50615 HYPOTHETICAL 40.8 KD PROTEIN (498 aa), FASTA scores: opt: 1703, E(): 0, (57.4% identity in 566 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 18 bp insertion, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (624 aa versus 618 aa). Q7TZL0 No NC_002945.3 Mycobrowser_v2 CDS 1993084 1994328 . + 0 Mb1798 conserved protein Mb1798, -, len: 414 aa. Equivalent to Rv1769, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Conserved hypothetical protein, similar to O88066|SCI35.31|AL031541 hypothetical protein from Streptomyces coelicolor (402 aa), FASTA scores: opt: 1341, E(): 0, (53.8% identity in 398 aa overlap). Q7TZK9 No conserved hypotheticals Rv1769 NC_002945.3 Mycobrowser_v2 CDS 1994336 1995622 . + 0 Mb1799 conserved protein Mb1799, -, len: 428 aa. Equivalent to Rv1770, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). Conserved hypothetical protein, highly similar in N-terminus to Q49882 Hypothetical protein from Mycobacterium leprae from cosmid L247 (83 aa), FASTA scores: opt: 301, E(): 1e-12,(56.5% identity in 85 aa overlap). Q7TZK8 No conserved hypotheticals Rv1770 NC_002945.3 Mycobrowser_v2 CDS 2001114 2002418 . + 0 Mb1806 cyp144 Probable cytochrome p450 144 CYP144 Mb1806, cyp144, len: 434 aa. Equivalent to Rv1777,len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 434 aa overlap). Probable cyp144,cytochrome p450 (EC 1.14.-.-), similar to CPXM_BACME|Q06069 cytochrome p450 (meg) (EC 1.14.99.-) (410 aa), FASTA scores: opt: 435 E(): 2.3e-16, (28.8% identity in 372 aa overlap). Also similar to several other Mycobacterium tuberculosis p450 genes including Rv0766c,Rv2266, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. Q7VET9 No NC_002945.3 Mycobrowser_v2 CDS 1995619 1996905 . + 0 Mb1800 l-gulono-1,4-lactone dehydrogenase Mb1800, -, len: 428 aa. Equivalent to Rv1771, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to e.g. GGLO_RAT|P10867 l-gulonolactone oxidase (ec 1.1.3.8) (439 aa), FASTA scores: opt: 862, E(): 0, (34.1% identity in 434 aa overlap). Also shows slight similarity to Mycobacterium tuberculosis oxidoreductase Rv1726|MTCY04C12.11 (22.9% identity in 441 aa overlap) and others e.g. Rv3107c, Rv1257c, Rv2251, etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site. Q7TZK7 No intermediary metabolism and respiration Rv1771 NC_002945.3 Mycobrowser_v2 CDS 1997094 1997405 . + 0 Mb1801 HYPOTHETICAL PROTEIN Mb1801, -, len: 103 aa. Equivalent to Rv1772, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Hypothetical unknown protein. Q7TZK6 No conserved hypotheticals Rv1772 NC_002945.3 Mycobrowser_v2 CDS 1997478 1998224 . - 0 Mb1802c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1802c, -, len: 248 aa. Equivalent to Rv1773c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Probable transcriptional regulator belonging to IclR family,similar to ICLR_ECOLI|P16528 acetate operon repressor from Escherichia coli (274 aa), FASTA scores: opt: 261, E(): 3.3e-10, (26.9% identity in 249 aa overlap). Also similar to Mycobacterium tuberculosis protein Rv1719|MTCY04C12.04 (40.2% identity in 244 aa overlap); and Rv2989. Start site chosen by homology, but may extend further upstream. Contains possible helix-turn-helix motif at aa 37-58 (+3.24 SD). Q7TZK5 No regulatory proteins Rv1773c NC_002945.3 Mycobrowser_v2 CDS 1998290 1999630 . + 0 Mb1803 PROBABLE OXIDOREDUCTASE Mb1803, -, len: 446 aa. Equivalent to Rv1774, len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 446 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to several e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa),FASTA scores: opt: 417, E(): 6e-20, (28.4% identity in 462 aa overlap). Also some similarity to Mycobacterium tuberculosis oxidoreductase MTCY04C12.11 (24.1% identity in 444 aa overlap). Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site. Q7TZK4 No intermediary metabolism and respiration Rv1774 NC_002945.3 Mycobrowser_v2 CDS 1999630 2000448 . + 0 Mb1804 CONSERVED HYPOTHETICAL PROTEIN Mb1804, -, len: 272 aa. Equivalent to Rv1775, len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, similar to O28806|AF1466 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (255 aa),FASTA scores: opt: 364, E(): 1e-17, (29.2% identity in 267 aa overlap). Q7TZK3 No conserved hypotheticals Rv1775 NC_002945.3 Mycobrowser_v2 CDS 2002539 2002988 . - 0 Mb1807c unknown protein Mb1807c, -, len: 149 aa. Equivalent to Rv1778c,len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 149 aa overlap). Hypothetical unknown protein. Q7TZK1 No conserved hypotheticals Rv1778c NC_002945.3 Mycobrowser_v2 CDS 2005760 2007934 . - 0 Mb1810c malQ PROBABLE 4-ALPHA-GLUCANOTRANSFERASE MALQ (Amylomaltase) (Disproportionating enzyme) (D-enzyme) Mb1810c, malQ, len: 724 aa. Equivalent to Rv1781c,len: 724 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 724 aa overlap). Probable malQ,4-ALPHA-GLUCANOTRANSFERASE (EC 2.4.1.25), similar to many,e.g. P15977|MALQ_ECOLI 4-ALPHA-GLUCANOTRANSFERASE (694 aa), FASTA scores: opt: 964, E(): 0, (31.8% identity in 694 aa overlap). BELONGS TO THE DISPROPORTIONATING ENZYME FAMILY. X2BIU5,P65337 No NC_002945.3 Mycobrowser_v2 CDS 2008198 2009718 . + 0 Mb1811 eccb5 esx conserved component eccb5. esx-5 type vii secretion system protein. probable membrane protein. Mb1811, -, len: 506 aa. Equivalent to Rv1782, len: 506 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 506 aa overlap). Probable conserved membrane protein, similar to four other Mycobacterium tuberculosis hypothetical membrane proteins e.g. O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa), FASTA scores: opt: 1106, E(): 0, (41.2% identity in 485 aa overlap); Rv0283, Rv3450c, and Rv3869, all located near ESAT-6 family genes. Also similar to O33088|MLCB628.17C|Y14967 cosmid B628 from Mycobacterium leprae (481 aa), (32.7% identity in 486 aa overlap); and equivalent to Q9Z5I3|MLCB596.27|AL035472 hypothetical protein from Mycobacterium leprae (506 aa) (82.6% identity in 506 aa overlap). Has hydrophobic stretch from aa 54-76. Q7TZJ8 No cell wall and cell processes Rv1782 NC_002945.3 Mycobrowser_v2 CDS 2009715 2013890 . + 0 Mb1812 eccc5 esx conserved component eccc5. esx-5 type vii secretion system protein. Mb1812, -, len: 1391 aa. Similar to Rv1783 and Rv1784, len: 435 aa and 932 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 435 aa overlap and 99.9% identity in 932 aa overlap). Rv1783: Probable conserved membrane protein. Member of family of Mycobacterium tuberculosis hypothetical proteins including O05450|Rv3894c|MTY15F10.18|Z94121 (1396 aa), FASTA scores: opt: 542, E(): 1.5e-26, (31.4% identity in 440 aa overlap); Rv3447c, Rv0284, Rv3870, Rv1784, and Rv3871, all linked to ESAT-6 family gene. Similar to N-terminal part of Rv3894c (1396 aa), Rv1784 is similar to remainder of Rv3894c. Also similar to O33087|MLCB628.16C|Y14967 Hypothetical protein from Mycobacterium leprae (744 aa),(30.0% identity in 437 aa overlap) and equivalent to N-terminal part of Q9Z5I2|MLCB596.28|AL035472 hypothetical protein from Mycobacterium leprae (1345 aa), (86.4% identity in 397 aa overlap). Rv1784: Conserved hypothetical protein, member of family of Mycobacterium tuberculosis hypothetical proteins including Rv3447c,Rv0284, Rv3870, Rv1783, Rv3871, Rv3894c, all linked to ESAT-6 family genes. Probably ATP-binding membrane proteins. Similar to C-terminal region of 006264|Rv3447c (1236 aa), (36.2% identity in 930 aa overlap). Equivalent to C-terminal region of Mycobacterium leprae hypothetical protein Q9Z512|MLCB596.28|AL035472 (1345 aa), (87.8% identity in 932 aa overlap); also similar to other hypothetical proteins e.g. MLCB628.14 from Mycobacterium leprae, (32.0% identity in 600 aa overlap); MLCB628.15 from Mycobacterium leprae, (35.0% identity in 280 aa overlap); and O86653|SC3C3.20|AL031231 ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 618, E(): 4.6e-30, (34.3% identity in 937 aa overlap). Contains two times PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis, a single base transversion (a-t) leads to a single product. Q7TZJ7 No NC_002945.3 Mycobrowser_v2 CDS 2015759 2016853 . + 0 Mb1815 PPE25 ppe family protein ppe25 Mb1815, PPE25, len: 364 aa. Equivalent to Rv1787,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 365 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FASTA scores: opt: 837, E(): 0, (52.0% identity in 406 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 8 bp to 5 bp substitution (agcccggt-ccggg), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa). Q7TZJ5 No NC_002945.3 Mycobrowser_v2 CDS 2016932 2017231 . + 0 Mb1816 PE18 pe family protein pe18 Mb1816, PE18, len: 99 aa. Equivalent to Rv1788,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins, similar to Z93777|MTCI364.07 Mycobacterium tuberculosis cosmid (99 aa), FASTA scores: opt: 414, E(): 3.6e-20, (72.4% identity in 98 aa overlap). Q7TZJ4 No PE/PPE Rv1788 NC_002945.3 Mycobrowser_v2 CDS 2017245 2018426 . + 0 Mb1817 PPE26 ppe family protein ppe26 Mb1817, PPE26, len: 393 aa. Equivalent to Rv1789,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 393 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to others e.g.Z98268|MTCI125.26 Mycobacterium tuberculosis cosmid (385 aa), FASTA score: opt: 1283, E(): 0, (62.7% identity in 408 aa overlap). Q7TZJ3 No NC_002945.3 Mycobrowser_v2 CDS 2018880 2019932 . + 0 Mb1818 PPE27 ppe family protein ppe27 Mb1818, PPE27, len: 350 aa. Equivalent to Rv1790,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 350 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich protein, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FASTA scores: opt: 849, E(): 0, (50.0% identity in 406 aa overlap). Q7TZJ2 No NC_002945.3 Mycobrowser_v2 CDS 2020359 2020658 . + 0 Mb1819 PE19 pe family protein pe19 Mb1819, PE19, len: 99 aa. Equivalent to Rv1791,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family, but no glycine rich C-terminus, highly similar to Z93777|MTCI364.07 M.tuberculosis cosmid (99 aa) opt: 430 E(): 2.4e-21,(75.5% identity in 98 aa overlap). Q7TZJ1 No PE/PPE Rv1791 NC_002945.3 Mycobrowser_v2 CDS 2020802 2021098 . + 0 Mb1820 esxM esat-6 like protein esxm Mb1820, esxM, len: 98 aa. Equivalent to Rv1792,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(98.0% identity in 98 aa overlap). esxM, conserved hypothetical protein, member of Mycobacterium tuberculosis QILSS familyof proteins, genes linked to those of ESAT-6 family. Has in-frame stop codon at 18074, no error could be found to account for this. Identical (apart from stop codon) to P96363|Rv1038c|MTCY10G2.11 PUTATIVE ESAT-6 LIKE PROTEIN 2 (98 aa), FASTA scores: opt: 389, E(): 5.8e-26,(100.0% identity in 58 aa overlap). Also identical to Rv1038c, Rv1197, and almost identical to Rv3620c and Rv2347c. Similar protein present in Mycobacterium leprae e.g. Q49946|MLCB1701.06C|AL049191 PUTATIVE ESAT-6 LIKE PROTEIN X (95 aa), FASTA scores: opt: 343, E(): 1.6e-17,(57.6% identity in 92 aa overlap). X2BIW1 No cell wall and cell processes Rv1792 NC_002945.3 Mycobrowser_v2 CDS 2021149 2021433 . + 0 Mb1821 esxN putative esat-6 like protein esxn (esat-6 like protein 5) Mb1821, esxN, len: 94 aa. Equivalent to Rv1793,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). esxN, putative ESAT-6 like protein, conserved hypothetical protein, almost identical to several hypothetical mycobacterial proteins of the ESAT-6-like family including P95242|Rv2346c|MTCY98.15C|Z83860 PUTATIVE ESAT-6 LIKE PROTEIN 6 (94 aa), FASTA scores: opt: 610, E(): 0, (97.9 % identity in 94 aa overlap); Rv3619c, Rv1037c, and Rv1198,etc. Also present in Mycobacterium leprae. X2BJ78 No cell wall and cell processes Rv1793 NC_002945.3 Mycobrowser_v2 CDS 2146986 2147579 . - 0 Mb1945c PROBABLE EXPORTED PROTEIN Mb1945c, -, len: 197 aa. Equivalent to Rv1910c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 197 aa overlap). Possible exported protein, very similar to upstream ORF MTCY180.07 (201 aa),FASTA score: E(): 0, (64.0% identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN PROTEIN CPN0877 from Chlamydophila pneumoniae (150 aa). X2BJG2 No cell wall and cell processes Rv1910c NC_002945.3 Mycobrowser_v2 CDS 2021521 2022423 . + 0 Mb1822 conserved protein Mb1822, -, len: 300 aa. Equivalent to Rv1794, len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Conserved hypothetical protein, slight similarity to Mycobacterium tuberculosis O53694|Rv0289|MTV035.17, (295 aa), FASTA scores: opt: 172, E(): 0.00083, (25.7% identity in 261 aa overlap). Equivalent to Mycobacterium leprae hypothetical protein Q9Z5I1|MLCB596.31|AL035472 (300 aa), (88.0% identity in 300 aa overlap). Contains PS00211 ABC transporters family signature. Q7TZJ0 No conserved hypotheticals Rv1794 NC_002945.3 Mycobrowser_v2 CDS 2032456 2033727 . + 0 Mb1829 PPE29 ppe family protein ppe29 Mb1829, PPE29, len: 423 aa. Equivalent to Rv1801,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 423 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to AL022021|MTV049.29|Rv1808 (409 aa), FASTA scores: opt: 1229, E(): 0, (55.2% identity in 422 aa overlap). TBparse score is 0.927. Q7TZI4 No NC_002945.3 Mycobrowser_v2 CDS 2022695 2024206 . + 0 Mb1823 eccd5 esx conserved component eccd5. esx-5 type vii secretion system protein. probable membrane protein. Mb1823, -, len: 503 aa. Equivalent to Rv1795, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 503 aa overlap). Conserved hypothetical membrane protein, has a hydrophilic stretch from ~1-130 then very hydrophobic. Similar to several other mycobacterial proteins, all linked to ESAT-6 family e.g. Rv3887c|MTY15F10.24|Z94121 (509 aa), FASTA scores: opt: 360, E(): 1.6e-15, (26.7% identity in 514 aa overlap); Rv3448, and Rv0290. Q7TZI9 No cell wall and cell processes Rv1795 NC_002945.3 Mycobrowser_v2 CDS 2024184 2025941 . + 0 Mb1824 mycp5 probable proline rich membrane-anchored mycosin mycp5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) Mb1824, -, len: 585 aa. Equivalent to Rv1796, len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 585 aa overlap). Conserved hypothetical Pro-rich protease. Member of family with four other Mycobacterium tuberculosis hypothetical proteases including Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa),FASTA scores: opt: 1173, E(): 0, (47.9% identity in 578 aa overlap); Rv0291, Rv3883c, and Rv3449. Genes all linked to those of ESAT-6 family. Has possible N-terminal signal peptide and hydrophobic anchor-like stretch at C-terminus. Contains two serine protease, subtilase family active site motifs: a aspartic acid active site motif (PS00136); and a histidine active site motif (PS00137). Q7TZI8 No intermediary metabolism and respiration Rv1796 NC_002945.3 Mycobrowser_v2 CDS 2025938 2027158 . + 0 Mb1825 ecce5 esx conserved component ecce5. esx-5 type vii secretion system protein. probable membrane protein. Mb1825, -, len: 406 aa. Equivalent to Rv1797, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Conserved hypothetical protein, some similarity to Mycobacterium tuberculosis O05462|Rv3882c|MTCY15F10.30|Z94121 (462 aa),FASTA scores: opt: 181, E(): 9.2e-05, (25.4% identity in 283 aa overlap). Has hydrophobic stretch near N-terminus. Q7TZI7 No cell wall and cell processes Rv1797 NC_002945.3 Mycobrowser_v2 CDS 2027155 2028987 . + 0 Mb1826 ecca5 esx conserved component ecca5. esx-5 type vii secretion system protein. Mb1826, -, len: 610 aa. Equivalent to Rv1798, len: 610 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 610 aa overlap). Conserved hypothetical protein, similar to several mycobacterial proteins e.g. O05460|MTCY15F10.28|Rv3884c|Z94121 from M. tuberculosis (619 aa), FASTA scores: opt: 669, E(): 0,(31.0% identity in 549 aa overlap); and O33089|MLCB628.18c|Y14967 from Mycobacterium leprae (573 aa), FASTA scores: opt: 723, E(): 0, (32.4% identity in 568 aa overlap). Also very similar to Rv0282. May belong to the CBXX/CFQX family as last ~320 aa domain very similar to several family members. Contains ATP/GTP-binding site motif A (P-loop; PS00017). X2BJ83,P63745 No cell wall and cell processes Rv1798 NC_002945.3 Mycobrowser_v2 CDS 2029614 2029805 . + 0 Mb1827 lppT PROBABLE LIPOPROTEIN LPPT Mb1827, lppT, len: 63 aa. Equivalent to Rv1799,len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Probable lppT lipoprotein, has possible signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TZI6 No cell wall and cell processes Rv1799 NC_002945.3 Mycobrowser_v2 CDS 2029908 2031875 . + 0 Mb1828 PPE28 ppe family protein ppe28 Mb1828, PPE28, len: 655 aa. Equivalent to Rv1800,len: 655 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 655 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, C-terminal very similar to parts of PE proteins e.g. Z92770|MTCI5.25|Rv0151c (588 aa), FASTA scores: opt: 1269, E(): 0, (41.5% identity in 591 aa overlap). Q7TZI5 No NC_002945.3 Mycobrowser_v2 CDS 2038527 2038826 . + 0 Mb1835 PE20 pe family protein pe20 Mb1835, PE20, len: 99 aa. Equivalent to Rv1806,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins, most similar to Rv1788|MTV049.10|AL022021 (99 aa), FASTA scores: opt: 334, E(): 4.7 e-15, (59.8% identity in 97 aa overlap). Q7TZH9 No PE/PPE Rv1806 NC_002945.3 Mycobrowser_v2 CDS 2048711 2049415 . + 0 Mb1846 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1846, -, len: 234 aa. Equivalent to Rv1816, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Possible transcriptional regulatory protein. MEME analysis suggests similarity to putative Mycobacterium tuberculosis transcriptional regulators, Rv0653c, Rv0681. Contains helix-turn-helix motif at aa 38-59 (+4.30 SD). X2BJA0,P67439 No regulatory proteins Rv1816 NC_002945.3 Mycobrowser_v2 CDS 2033839 2035230 . + 0 Mb1830 PPE30 ppe family protein ppe30 Mb1830, PPE30, len: 463 aa. Equivalent to Rv1802,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to AL022021|MTV049.30|Rv1809 (468 aa), FASTA scores: opt: 1238, E(): 0, (51.0% identity in 471 aa overlap). X2BIX6 No NC_002945.3 Mycobrowser_v2 CDS 2035378 2037000 . - 0 Mb1831c PE_PGRS32b PE-PGRS FAMILY PROTEIN [SECOND PART] Mb1831c, PE_PGRS32b, len: 540 aa. Equivalent to 3' end of Rv1803c, len: 639 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 540 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Most similar to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt: 1827, E( ): 0, (53.5% identity in 664 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b, with PE_PGRS32a being truncated. Q7TZI3 No NC_002945.3 Mycobrowser_v2 CDS 2037034 2037297 . - 0 Mb1832c PE_PGRS32a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb1832c, PE_PGRS32a, len: 87 aa. Equivalent to 5' end of Rv1803c, len: 639 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 87 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Most similar to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt: 1827, E( ): 0, (53.5% identity in 664 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b, with PE_PGRS32a being truncated. Q7TZI2 No NC_002945.3 Mycobrowser_v2 CDS 2037478 2037804 . - 0 Mb1833c conserved protein Mb1833c, -, len: 108 aa. Equivalent to Rv1804c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Conserved hypothetical protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (hydrophobic stretch at N-terminus) e.g. O07222|Rv1810|MTCY16F9.04C|Z96073 (118 aa), FASTA scores: opt: 361, E(): 2.3e-19, (53.5% identity in 101 aa overlap); Rv0622, Rv1690, and Rv3067, etc. Q7TZI1 No conserved hypotheticals Rv1804c NC_002945.3 Mycobrowser_v2 CDS 2038142 2038489 . - 0 Mb1834c HYPOTHETICAL PROTEIN Mb1834c, -, len: 115 aa. Equivalent to Rv1805c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Hypothetical unknown protein. Q7TZI0 No conserved hypotheticals Rv1805c NC_002945.3 Mycobrowser_v2 CDS 2065923 2066180 . + 0 Mb1862 HYPOTHETICAL PROTEIN Mb1862, -, len: 85 aa. Equivalent to Rv1831, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Hypothetical unknown protein. X2BJ45 No conserved hypotheticals Rv1831 NC_002945.3 Mycobrowser_v2 CDS 2038853 2040052 . + 0 Mb1836 PPE31 ppe family protein ppe31 Mb1836, PPE31, len: 399 aa. Equivalent to Rv1807,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 399 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1789|MTV049.11|AL022021 (393 aa), FASTA scores: opt: 1169, E(): 0, (49.5% identity in 399 aa overlap). Start changed since original submission. Q7TZH8 No NC_002945.3 Mycobrowser_v2 CDS 2244905 2245321 . + 0 Mb2042 conserved protein Mb2042, -, len: 138 aa. Equivalent to Rv2019, len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Hypothetical protein. Q7TZ54 No conserved hypotheticals Rv2019 NC_002945.3 Mycobrowser_v2 CDS 2040376 2041605 . + 0 Mb1837 PPE32 ppe family protein ppe32 Mb1837, PPE32, len: 409 aa. Equivalent to Rv1808,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 409 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1800|MTV049.22|AL022021 (655 aa), FASTA scores: opt: 1225, E(): 0, (55.1% identity in 423 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. TBparse score is 0.919. Q7TZH7 No NC_002945.3 Mycobrowser_v2 CDS 2041737 2042300 . + 0 Mb1838 PPE33a PPE FAMILY PROTEIN [FIRST PART] Mb1838, PPE33a, len: 187 aa. Equivalent to 5' end of Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 187 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in 471 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits PPE33 into 2 parts, PPE33a and PPE33b, with PPE33a being truncated. Q7TZH6 No NC_002945.3 Mycobrowser_v2 CDS 2042301 2043149 . + 0 Mb1839 PPE33b PPE FAMILY PROTEIN [SECOND PART] Mb1839, PPE33b, len: 282 aa. Equivalent to 3' end of Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in 471 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t), splits PPE33 into 2 parts, PPE33a and PPE33b, with PPE33a being truncated. No NC_002945.3 Mycobrowser_v2 CDS 2043388 2043744 . + 0 Mb1840 conserved protein Mb1840, -, len: 118 aa. Equivalent to Rv1810, len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (possible N-terminal signal sequence) e.g. O53953|Rv1804c|MTV049.26c|AL022021 (108 aa), FASTA scores: opt: 361, E(): 9.6e-17, (53.5% identity in 101 aa overlap); Rv0622, and Rv1690, etc. Q7TZH5 No conserved hypotheticals Rv1810 NC_002945.3 Mycobrowser_v2 CDS 2043898 2044602 . + 0 Mb1841 mgtC POSSIBLE Mg2+ TRANSPORT P-TYPE ATPASE C MGTC Mb1841, -, len: 234 aa. Equivalent to Rv1811, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Possible mgtC,magnesium (Mg2+) transport P-type ATPase C (transmembrane protein) (EC 3.6.3.1), highly similar to many e.g. NP_442124.1|NC_000911 Mg2+ transport ATPase from Synechocystis sp. strain PCC 6803 (234 aa); NP_251248.1|NC_002516 probable transport protein from Pseudomonas aeruginosa (230 aa); P22037|ATMC_SALTY|STM3764 magnesium transport ATPase protein C from Salmonella typhimurium (231 aa), FASTA scores: opt: 545, E(): 4.1e-30, (42.3% identity in 220 aa overlap); N-terminus of NP_213315.1|NC_000918 Mg(2+) transport ATPase from Aquifex aeolicus (225 aa); etc. BELONGS TO THE MGTC / SAPB FAMILY Q7TZH4 No cell wall and cell processes Rv1811 NC_002945.3 Mycobrowser_v2 CDS 2044612 2045814 . - 0 Mb1842c PROBABLE DEHYDROGENASE Mb1842c, -, len: 400 aa. Equivalent to Rv1812c,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 400 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to other dehydrogenases/oxidases e.g. AE001947|AE001947_10 NADH dehydrogenase II of Deinococcus radiodurans (379 aa), FASTA scores: opt: 404,E(): 3.4e-18, (26.4% identity in 363 aa overlap) and DHNA_HAEIN|P44856 nadh dehydrogenase (EC 1.6.99.3) (444 aa), FASTA scores: opt: 200, E(): 8.5e-06, (23.3% identity in 258 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases Rv0392c, and Rv1854c|MTCY359.19 ndh probable NADH dehydrogenase (31.5% identity in 321 aa overlap). Q7TZH3 No intermediary metabolism and respiration Rv1812c NC_002945.3 Mycobrowser_v2 CDS 2046136 2046567 . - 0 Mb1843c CONSERVED HYPOTHETICAL PROTEIN Mb1843c, -, len: 143 aa. Equivalent to Rv1813c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein. Possibly a exported protein with potential N-terminal signal sequence. Similar to Q11050|Rv1269c|MTCY50.13 hypothetical protein from Mycobacterium tuberculosis (124 aa), (42.7% identity in 143 aa overlap). X2BIJ9,P64890 No conserved hypotheticals Rv1813c NC_002945.3 Mycobrowser_v2 CDS 2046976 2047878 . + 0 Mb1844 erg3 MEMBRANE-BOUND C-5 STEROL DESATURASE ERG3 (STEROL-C5-DESATURASE) Mb1844, erg3, len: 300 aa. Equivalent to Rv1814,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). erg3, transmembrane C-5 sterol desaturase (EC 1.3.-.-) (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). BELONGS TO THE STEROL DESATURASE FAMILY. [* note work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases]. X2BJ51,P68434 No lipid metabolism Rv1814 NC_002945.3 Mycobrowser_v2 CDS 2047983 2048648 . + 0 Mb1845 conserved protein Mb1845, -, len: 221 aa. Equivalent to Rv1815, len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 221 aa overlap). Conserved hypothetical protein, similar to G473456 hypothetical protein from Mycobacterium fortuitum (255 aa), FASTA scores: opt: 182,E(): 3.2e-05, (29.6% identity in 230 aa overlap). X2BIZ5,P59981 No conserved hypotheticals Rv1815 NC_002945.3 Mycobrowser_v2 CDS 2050050 2051513 . + 0 Mb1848 POSSIBLE FLAVOPROTEIN Mb1848, -, len: 487 aa. Equivalent to Rv1817, len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 487 aa overlap). Possible flavoprotein, similar to G746486 flavoprotein subunit of fumarate reductase fad domain homologue (474 aa), FASTA scores: opt: 223, E(): 5.7e-07, (24.1% identity in 489 aa overlap); and AJ236923|SFR236923_3 soluble fumarate reductase of Shewanella frigidimarina ifcA (588 aa), FASTA scores: opt: 310, E(): 2.5e-11, (27.3% identity in 484 aa overlap). Q7TZH1 No intermediary metabolism and respiration Rv1817 NC_002945.3 Mycobrowser_v2 CDS 2051633 2053138 . - 0 Mb1849c PE_PGRS33 pe-pgrs family protein pe_pgrs33 Mb1849c, PE_PGRS33, len: 501 aa. Equivalent to Rv1818c, len: 498 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 501 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see first citation),similar to many. Contains 2 x PS00583 pfkB family of carbohydrate kinases signature 1. Supposed localised to the cell surface. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp insertion (*-gccgccggc), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa). Q7TZH0 No NC_002945.3 Mycobrowser_v2 CDS 2053273 2055192 . - 0 Mb1850c baca probable drug-transport transmembrane atp-binding protein abc transporter baca Mb1850c, -, len: 639 aa. Equivalent to Rv1819c,len: 639 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 639 aa overlap). Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), equivalent to AL008609|MLCB1788.47 hypothetical ABC transporter from Mycobacterium leprae (638 aa), (74.9% identity in 634 aa overlap). Also similar to other transmembrane ATP-binding proteins e.g. Q57335|Y036_HAEIN hypothetical ABC transporter ATP-binding protein from Haemophilus influenzae (592 aa), FASTA scores: opt: 1235, E(): 2.8e-61, (40.8% identity in 623 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TZG9 No cell wall and cell processes Rv1819c NC_002945.3 Mycobrowser_v2 CDS 2055263 2056906 . + 0 Mb1851 ilvG Probable Acetolactate synthase ilvG (Acetohydroxy-acid synthase)(ALS) Mb1851, ilvG, len: 547 aa. Equivalent to Rv1820,len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 547 aa overlap). Probable ilvG,acetolactate synthase (EC 4.1.3.18). Equivalent to AL008609|MLCB1788.46c ilvG from Mycobacterium leprae (548 aa) (86.1% identity in 548 aa overlap). Similar to ILVB_KLEPN|P27696 (559 aa), FASTA scores: opt: 660, E(): 2.9e-34, (29.1% identity in 549 aa overlap). Also similar to other Mycobacterium tuberculosis Ilv proteins e.g. Rv3003c (ilvB), etc. Contains PS00187 Thiamine pyrophosphate enzymes signature. X2BJA5,P66947 No intermediary metabolism and respiration Rv1820 NC_002945.3 Mycobrowser_v2 CDS 2056921 2059347 . + 0 Mb1852 secA2 possible preprotein translocase atpase seca2 Mb1852, secA2, len: 808 aa. Equivalent to Rv1821,len: 808 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 808 aa overlap). Possible secA2,preprotein translocase, component of secretion apparatus,similar to several preprotein translocases e.g. P28366|SECA_BACSU preprotein translocase secA subunit from Bacillus subtilis (841 aa), FASTA scores: opt: 1424, E(): 0, (35.9% identity in 786 aa overlap). Equivalent to AL008609|MLCB1788.45 Preprotein translocase SecA 2 from Mycobacterium leprae (778 aa) (87.1% identity in 780 aa overlap). Also similar to Rv3240c|MTCY20B11.15c secA preprotein translocase from Mycobacterium tuberculosis (949 aa). COULD BE PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c,SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. X2BJ36,P66786 No NC_002945.3 Mycobrowser_v2 CDS 2059544 2060173 . + 0 Mb1853 pgsA2 PROBABLE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE) Mb1853, pgsA2, len: 209 aa. Equivalent to Rv1822,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable pgsA2,CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase (EC 2.7.8.5) (see citation below), integral membrane protein, equivalent to AL008609|MLCB1788_17 phosphatidyltransferase from Mycobacterium leprae (206 aa), FASTA score: (76.6% identity in 205 aa overlap). Also highly similar or similar to others e.g. CAB88885.1|AL353861 putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Streptomyces coelicolor (215 aa); AAC44003.1|U29587 phosphatidylglycerol phosphate synthase from Rhodobacter sphaeroides (227 aa); NP_405431.1|NC_003143 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Yersinia pestis (182 aa); P06978|PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (181 aa),FASTA scores: opt: 252, E(): 2.8e-09, (29.7% identity in 175 aa overlap); etc. Also similar to Rv2746c|PGSA3|MTV002.11c CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE (PGP SYNTHASE) from Mycobacterium tuberculosis (209 aa). Contains PS00379 CDP-alcohol phosphatidyltransferases signature; and PS00075 Dihydrofolate reductase signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. X2BIK7,P63754 No NC_002945.3 Mycobrowser_v2 CDS 2060166 2061089 . + 0 Mb1854 conserved protein Mb1854, -, len: 307 aa. Equivalent to Rv1823, len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Conserved hypothetical protein, similar to P71582|MTCY10H4.12|RV0012 hypothetical protein CY10H4.12 from Mycobacterium tuberculosis (262 aa), FASTA scores: opt: 304, E(): 1.5e-12, (30.1% identity in 246 aa overlap). X2BJ59,P64892 No conserved hypotheticals Rv1823 NC_002945.3 Mycobrowser_v2 CDS 2061118 2061483 . + 0 Mb1855 CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1855, -, len: 121 aa. Equivalent to Rv1824, len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 121 aa overlap). Conserved hypothetical membrane protein similar to P28265|SBP_BACSU sbp protein from Bacillus subtilis (121 aa), FASTA scores: opt: 261, E(): 1.9e-12, (38.9% identity in 113 aa overlap). X2BJ09,P64894 No cell wall and cell processes Rv1824 NC_002945.3 Mycobrowser_v2 CDS 2061500 2062378 . + 0 Mb1856 conserved protein Mb1856, -, len: 292 aa. Equivalent to Rv1825, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Conserved hypothetical protein, weak similarity to Mycobacterium tuberculosis hypothetical proteins Q50610|MTCY1A11.20C|Rv1823|Z78020 (307 aa), FASTA scores: opt: 182, E(): 0.00044, (29.9% identity in 204 aa overlap); and Rv0012. Has a hydrophobic stretch, TMhelix from aa 67 to 85 X2BJA8,P64896 No conserved hypotheticals Rv1825 NC_002945.3 Mycobrowser_v2 CDS 2062416 2062820 . + 0 Mb1857 gcvH PROBABLE GLYCINE CLEAVAGE SYSTEM H PROTEIN GCVH Mb1857, gcvH, len: 134 aa. Equivalent to Rv1826,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Probable gcvH, glycine cleavage system H protein, highly similar to GCSH_ECOLI|P23884 glycine cleavage system H protein from Escherichia coli (129 aa), FASTA scores: opt: 428, E(): 2.2e-22, (47.8% identity in 134 aa overlap). Equivalent to MLCB1788.37c gcvH from Mycobacterium leprae (78.4% identity in 134 aa overlap). Contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. BELONGS TO THE GCVH FAMILY. X2BJ41,Q7TZG8 No intermediary metabolism and respiration Rv1826 NC_002945.3 Mycobrowser_v2 CDS 2063060 2063548 . + 0 Mb1858 gara conserved protein with fha domain, gara Mb1858, cfp17, len: 162 aa. Equivalent to Rv1827,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). cfp17, conserved hypothetical protein (see citation below), equivalent to O32919|MLCB1788.36c hypothetical protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 888,E(): 0, (87.0% identity in 161 aa overlap). X2BIL3 No NC_002945.3 Mycobrowser_v2 CDS 2066229 2069054 . + 0 Mb1863 gcvB Probable glycine dehydrogenase gcvB (Glycine decarboxylase) (Glycine cleavage system P-protein) Mb1863, gcvB, len: 941 aa. Equivalent to Rv1832,len: 941 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 941 aa overlap). Probable gcvB, glycine dehydrogenase [decarboxylating] (EC 1.4.4.2), highly similar to GCSP_ECOLI|P33195 glycine dehydrogenase (decarboxylating) from Escherichia coli (957 aa), FASTA scores: opt: 2194, E(): 0, (55.4% identity in 961 aa overlap). THE GLYCINE CLEAVAGE SYSTEM IS COMPOSED OF FOUR PROTEINS: P, T, L, AND H. X2BIL8,Q7VET8 No intermediary metabolism and respiration Rv1832 NC_002945.3 Mycobrowser_v2 CDS 2087856 2088170 . + 0 Mb1880 ureB urease beta subunit ureb (urea amidohydrolase) Mb1880, ureB, len: 104 aa. Equivalent to Rv1849,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). ureB, urease beta subunit (EC 3.5.1.5). Identical to URE2_MYCTU|P50048 urease beta subunit from Mycobacterium tuberculosis (100 aa). BELONGS TO THE UREASE GAMMA SUBUNIT FAMILY. X2BJ38,P0A663 No intermediary metabolism and respiration Rv1849 NC_002945.3 Mycobrowser_v2 CDS 2069281 2070141 . - 0 Mb1864c Possible haloalkane dehalogenase Mb1864c, -, len: 286 aa. Equivalent to Rv1833c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible haloalkane dehalogenase (EC 3.8.1.5). Similar to several haloalkane dehalogenase e.g. CAB45532.1|AJ243259 from Mycobacterium bovis (300 aa); also similar to LINB_PSEPA|P51698 1,3,4,6-tetrachloro-1,4-cyclohexadien from Pseudomonas paucimobilis (295 aa), FASTA scores: opt: 314, E(): 1.5e-13, (33.1% identity in 281 aa overlap). X2BJ69,P64304 No intermediary metabolism and respiration Rv1833c NC_002945.3 Mycobrowser_v2 CDS 2070182 2071048 . + 0 Mb1865 lipz Probable hydrolase Mb1865, -, len: 288 aa. Equivalent to Rv1834, len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 288 aa overlap). Probable hydrolase (EC 3.-.-.-), some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kd protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). Q7VET7 No intermediary metabolism and respiration Rv1834 NC_002945.3 Mycobrowser_v2 CDS 2071053 2072939 . - 0 Mb1866c CONSERVED HYPOTHETICAL PROTEIN Mb1866c, -, len: 628 aa. Equivalent to Rv1835c,len: 628 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 628 aa overlap). Conserved hypothetical protein, some similarity to putative acylases e.g. G216374 glutaryl 7-aca acylase precursor (634 aa) FASTA scores, opt: 202, E(): 3.5e-06, (25.1% identity in 669 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2800 and Rv1215c. X2BJC0,P0A5F6 No conserved hypotheticals Rv1835c NC_002945.3 Mycobrowser_v2 CDS 2096782 2097891 . + 0 Mb1890 modC PROBABLE MOLYBDENUM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MODC Mb1890, modC, len: 369 aa. Equivalent to Rv1859,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 369 aa overlap). Probable modC,molybdenum-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. Y10817|ANY108176 ModC from Arthrobacter (349 aa), FASTA scores: opt: 895, E(): 0, (46.0% identity in 361 aa overlap); etc. Shows similarity to other Mycobacterium tuberculosis ABC-transporter proteins e.g. Rv0073, Rv1238,Rv2564, etc. Contains both PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signatures involved in molybdate uptake. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TZF4 No cell wall and cell processes Rv1859 NC_002945.3 Mycobrowser_v2 CDS 2072955 2074988 . - 0 Mb1867c conserved protein Mb1867c, -, len: 677 aa. Equivalent to Rv1836c,len: 677 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 677 aa overlap). Conserved hypothetical protein. Equivalent to MLCB1788.28|AL008609 hypothetical protein from Mycobacterium leprae (710 aa), FASTA scores: opt: 2938, E(): 0, (66.0% identity in 714 aa overlap). Contains PS00036 bZIP transcription factors basic domain signature. Q7TZG6 No conserved hypotheticals Rv1836c NC_002945.3 Mycobrowser_v2 CDS 2075108 2077333 . - 0 Mb1868c glcB malate synthase g glcb Mb1868c, glcB, len: 741 aa. Equivalent to Rv1837c,len: 741 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 741 aa overlap). Probable glcB, malate synthase G (EC 4.1.3.2) (see citations below), highly similar to MASY_CORGL|P42450 malate synthase (738 aa),FASTA score: opt: 2961, E(): 0, (61.3% identity in 724 aa overlap). BELONGS TO THE MALATE SYNTHASE G FAMILY. X2BIM5,P0A5J5 No NC_002945.3 Mycobrowser_v2 CDS 2077609 2078004 . - 0 Mb1869c vapc13 possible toxin vapc13 Mb1869c, -, len: 131 aa. Equivalent to Rv1838c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein. Part of 14-membered Mycobacterium tuberculosis protein family with Rv2863|MTV003.09|AL008883 (126 aa), FASTA scores: opt: 293, E(): 1.5e-14, (38.2% identity in 123 aa overlap); Rv0749, Rv0277c, Rv2530c,etc. Also similar to AJ248288|CNSPAX06_181 Pyrococcus abyssi complete genome (136 aa), FASTA scores: opt: 197,E(): 2.2e-07, (33. 1% identity in 133 aa overlap). X2BJ75,P64902 No virulence, detoxification, adaptation Rv1838c NC_002945.3 Mycobrowser_v2 CDS 2078323 2079723 . - 0 Mb1871c PE_PGRS34 pe-pgrs family protein pe_pgrs34 Mb1871c, PE_PGRS34, len: 466 aa. Similar to Rv1840c, len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, (90.485% identity in 515 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to many e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 1693, E(): 0, (53.1% identity in 612 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 147 bp leads to a longer protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). Q7TZG4 No NC_002945.3 Mycobrowser_v2 CDS 2113383 2113820 . + 0 Mb1904 CONSERVED HYPOTHETICAL PROTEIN Mb1904, -, len: 145 aa. Equivalent to Rv1873, len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 145 aa overlap). Conserved hypothetical protein. Some similarity to AL591783 hypothetical protein from Sinorhizobium meliloti. Q7TZE3 No conserved hypotheticals Rv1873 NC_002945.3 Mycobrowser_v2 CDS 2079886 2080935 . - 0 Mb1872c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1872c, -, len: 349 aa. Equivalent to Rv1841c,len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 349 aa overlap). Conserved hypothetical membrane protein. Some similarity to O07585|YHDP_BACSU HYPOTHETICAL 49.9 KD PROTEIN from Bacillus subtilis (444 aa), FASTA scores: opt: 620, E(): 0, (31.1% identity in 350 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv1842c, Rv2366c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa). Q7TZG3 No cell wall and cell processes Rv1841c NC_002945.3 Mycobrowser_v2 CDS 2080935 2082302 . - 0 Mb1873c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1873c, -, len: 455 aa. Equivalent to Rv1842c,len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 455 aa overlap). Conserved hypothetical membrane protein. Similar to Z99109|0O7589 Potential integral membrane protein from Bacillus subtilis (461 aa),FASTA scores: opt: 723, E(): 0, (31.2% identity in 449 aa overlap). Similar to other Mycobacterium tuberculosis putative integral membrane proteins e.g. Rv2366c,Rv1841c. Q7TZG2 No cell wall and cell processes Rv1842c NC_002945.3 Mycobrowser_v2 CDS 2088170 2089903 . + 0 Mb1881 ureC Urease alpha subunit ureC (Urea amidohydrolase) Mb1881, ureC, len: 577 aa. Equivalent to Rv1850,len: 577 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 577 aa overlap). ureC, urease alpha subunit (EC 3.5.1.5). Similar to URE1_MYCTU|P50042 from M. tuberculosis (577 aa), FASTA scores: opt: 3794, E(): 0,(98.3% identity in 577 aa overlap). Contains PS00145 Urease active site motif. BELONGS TO THE UREASE FAMILY. X2BJE0,P0A661 No intermediary metabolism and respiration Rv1850 NC_002945.3 Mycobrowser_v2 CDS 2082476 2083915 . - 0 Mb1874c guaB1 PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) Mb1874c, guaB1, len: 479 aa. Equivalent to Rv1843c,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Probable guaB1,inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). Similar to others e.g. IMDH_BACSU|P21879 from Bacillus subtilis (513 aa), FASTA score: opt: 904, E(): 0, (37.8% identity in 471 aa overlap). Similar to other Mycobacterium tuberculosis proteins e.g. guaB2, Rv3411c. X2BJ81,P65173 No NC_002945.3 Mycobrowser_v2 CDS 2124498 2125097 . - 0 Mb1917c chorismate mutase Mb1917c, -, len: 199 aa. Equivalent to Rv1885c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Conserved hypothetical protein, some similarity to P42517|CHMU_ERWHE MONOFUNCTIONAL CHORISMATE MUTASE (181 aa), FASTA score: opt: 181, E(): 0.00017, (28.6% identity in 133 aa overlap). Q7TZD2 No intermediary metabolism and respiration Rv1885c NC_002945.3 Mycobrowser_v2 CDS 2083281 2085338 . - 0 Mb1875c gnd1 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 Mb1875c, gnd1, len: 705 aa. Similar to 5' end of Rv1844c, len: 485 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 404 aa overlap). Probable gnd1, 6-phosphogluconate dehydrogenase (EC 1.1.1.44). Similar to others e.g. 6PGD_ECOLI|P00350 from Escherichia coli (468 aa), FASTA scores: opt: 1661, E(): 0, (53.6% identity in 466 aa overlap); etc. Also similar to Rv1122|MTCY22G8.11|gnd2 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING from Mycobacterium tuberculosis (340 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c is most similar to gnd's from Gram negative organisms, while Rv1122|MTCY22G8.11|gnd2 is most similar to gnd's from Gram positive organisms. BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (705 aa versus 485 aa). Q7TZG1 No NC_002945.3 Mycobrowser_v2 CDS 2085428 2086378 . - 0 Mb1876c blar possible sensor-transducer protein blar Mb1876c, -, len: 316 aa. Equivalent to Rv1845c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 316 aa overlap). Conserved hypothetical transmembrane protein. Equivalent to MLCB1788.18|AL008609 Hypothetical protein from Mycobacterium leprae (316 aa), FASTA scores: opt: 1762,E(): 0, (87.6% identity in 314 aa overlap). Similar to proteins in Streptomyces coelicolor e.g. SC10A7.04|AL078618.1. Q7TZG0 No cell wall and cell processes Rv1845c NC_002945.3 Mycobrowser_v2 CDS 2087086 2087508 . + 0 Mb1878 conserved protein Mb1878, -, len: 140 aa. Equivalent to Rv1847, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 140 aa overlap=. Conserved hypothetical protein, possible thioesterase, some similarity to YBDB proteins of Escherichia coli and H. influenzae e.g. P15050|YBDB_ECOLI HYPOTHETICAL 15.0 KD PROTEIN IN ENTA-CSTA INTERGENIC REGION (137 aa), FASTA scores: opt: 232, E(): 6.6e-10, (35.8% identity in 106 aa overlap); C48956|G142208 thioesterase from Arthrobacter sp (151 aa),FASTA score: opt: 254, E(): 1.7e-11, (33.3% identity in 138 aa overlap). Also similar to AF064959|AF064959_1 hypothetical protein from Coxiella burnetii (148 aa),FASTA score: opt: 264, E(): 9.3e- 12, (36.8% identity in 117 aa overlap). Q7TZF8 No conserved hypotheticals Rv1847 NC_002945.3 Mycobrowser_v2 CDS 2087557 2087859 . + 0 Mb1879 ureA Urease gamma subunit ureA (Urea amidohydrolase) Mb1879, ureA, len: 100 aa. Equivalent to Rv1848,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). ureA, urease gamma subunit (EC 3.5.1.5). Similar to URE3_MYCTU|P50043 from Mycobacterium tuberculosis (100 aa), FASTA scores: opt: 630, E(): 1.3e-36, (99.0% identity in 100 aa overlap). BELONGS TO THE UREASE GAMMA SUBUNIT FAMILY. X2BJ86,P0A677 No intermediary metabolism and respiration Rv1848 NC_002945.3 Mycobrowser_v2 CDS 2091231 2091857 . + 0 Mb1884 ureD Probable urease accessory protein ureD Mb1884, ureD, len: 208 aa. Equivalent to Rv1853,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). ureD, probable urease accessory protein. Similar to URED_YEREN|P42868 Urease operon ureD protein from Yersinia enterocolitica (325 aa),Fasta scores: opt: 114, E(): 0.37, (25.2% identity in 119 aa overlap). Q7VET5 No intermediary metabolism and respiration Rv1853 NC_002945.3 Mycobrowser_v2 CDS 2129311 2129922 . - 0 Mb1923c HYPOTHETICAL PROTEIN Mb1923c, -, len: 203 aa. Equivalent to Rv1890c,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Hypothetical unknown protein. Q7TZC7 No conserved hypotheticals Rv1890c NC_002945.3 Mycobrowser_v2 CDS 2091860 2093251 . - 0 Mb1885c ndh PROBABLE NADH DEHYDROGENASE NDH Mb1885c, ndh, len: 463 aa. Equivalent to Rv1854c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 463 aa overlap). Probable ndh, NADH dehydrogenase (EC 1.6.99.3) (see citations below), similar to several e.g. S74826 NADH dehydrogenase from Synechocystis sp. (445 aa), FASTA score: opt: 1228, E(): 0, (46.3% identity in 432 aa overlap). Highly similar to Rv0392c|Z84725|g1817703 from Mycobacterium tuberculosis (470 aa), FASTA scores: opt: 1911, E(): 0, (64.7% identity in 459 aa overlap); and Rv1812c. Q7TZF7 No NC_002945.3 Mycobrowser_v2 CDS 2093392 2094315 . - 0 Mb1886c POSSIBLE OXIDOREDUCTASE Mb1886c, -, len: 307 aa. Equivalent to Rv1855c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Possible oxidoreductase (EC 1.-.-.-), possibly a monooxygenase. Contains PS00217 Sugar transport proteins signature 2,probably fortuitously. Similar to G487716 (78-11) LINCOMYCIN PRODUCTION GENES (29.2% identity in 154 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, etc. Q7TZF6 No intermediary metabolism and respiration Rv1855c NC_002945.3 Mycobrowser_v2 CDS 2094354 2095031 . - 0 Mb1887c POSSIBLE OXIDOREDUCTASE Mb1887c, -, len: 225 aa. Equivalent to Rv1856c,len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 225 aa overlap). Possible oxidoreductase (EC 1.-.-.-). Equivalent to MLCB1788.11c|AL008609 OXIDOREDUCTASE from Mycobacterium leprae (224 aa), FASTA scores: opt: 1211, E(): 0; (80.4% identity in 224 aa overlap). Some similarity to dehydrogenases of short-chain dehydrogenase/reductase family and fatty-acyl CoA reductases e.g. P16543|DHK2_STRVN GRANATICIN POLYKETIDE SYNTHASE P (249 aa), FASTA score: opt: 194, E(): 1.1e-05, (32.5% identity in 237 aa overlap). Q7TZF5 No intermediary metabolism and respiration Rv1856c NC_002945.3 Mycobrowser_v2 CDS 2095193 2095978 . + 0 Mb1888 modA PROBABLE MOLYBDATE-BINDING LIPOPROTEIN MODA Mb1888, modA, len: 261 aa. Equivalent to Rv1857,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable modA,molybdate-binding protein attached to membrane by lipid-modified N-terminal cysteine (contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site),component of molybdate transport system (see citation below). Shows strong similarity to precursors of periplasmic molybdate/sulphate binding proteins e.g. O31229|Y10817|ANY108174 ModA from Arthrobacter nicotinovorans (260 aa), FASTA score: opt: 725, E(): 0,(47.8% identity in 249 aa overlap). X2BIP4,P0A5Y1 No cell wall and cell processes Rv1857 NC_002945.3 Mycobrowser_v2 CDS 2095981 2096775 . + 0 Mb1889 modB probable molybdenum-transport integral membrane protein abc transporter modb Mb1889, modB, len: 264 aa. Equivalent to Rv1858,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Probable modB,molybdenum-transport integral membrane protein ABC transporter (see citation below), similar to others e.g. Y10817|ANY108175 ModB from Arthrobacter (239 aa), FASTA scores: opt: 937, E(): 0, (67.8% identity in 230 aa overlap); etc. Similar to other Mycobacterium tuberculosis transport proteins e.g. Rv2039c, Rv2316, etc. X2BJ95,P0A625 No cell wall and cell processes Rv1858 NC_002945.3 Mycobrowser_v2 CDS 2097944 2098921 . + 0 Mb1891 apa ALANINE AND PROLINE RICH SECRETED PROTEIN APA (FIBRONECTIN ATTACHMENT PROTEIN) (Immunogenic protein MPT32) (Antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) Mb1891, apa, len: 325 aa. Equivalent to Rv1860,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). apa (alternate gene names: mpt32, modD), Ala-, Pro-rich 45/47 kDa secreted protein, very similar to P46842|N43L_MYCLE from Mycobacterium leprae (287 aa), FASTA scores: opt: 1166,E(): 0, (66.4% identity in 298 aa overlap). Known to be glycosylated fibronectin-binding protein (see some citations). TBparse score is 0.924. X2BJF2,O30620 No cell wall and cell processes Rv1860 NC_002945.3 Mycobrowser_v2 CDS 2099373 2099678 . + 0 Mb1892 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb1892, -, len: 101 aa. Equivalent to Rv1861, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Probable conserved transmembrane protein, showing weak similarity to AE002069|AE002069_10 hypothetical protein from Deinococcus radiodurans (146 aa), FASTA scores: opt: 154, E(): 0.0027,(30.8% identity in 104 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TZF3 No cell wall and cell processes Rv1861 NC_002945.3 Mycobrowser_v2 CDS 2099753 2100793 . + 0 Mb1893 adhA Probable alcohol dehydrogenase adhA Mb1893, adhA, len: 346 aa. Equivalent to Rv1862,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap=. Probable adhA,alcohol dehydrogenase (EC 1.1.1.1), similar to ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Q7VET4 No intermediary metabolism and respiration Rv1862 NC_002945.3 Mycobrowser_v2 CDS 2100800 2101570 . - 0 Mb1894c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb1894c, -, len: 256 aa. Equivalent to Rv1863c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable conserved integral membrane protein, similar to Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from Mycobacterium tuberculosis (209 aa), FASTA scores: opt: 199, E(): 1e-06, (33.2% identity in 220 aa overlap); and Rv0658c. Q7TZF2 No cell wall and cell processes Rv1863c NC_002945.3 Mycobrowser_v2 CDS 2101563 2102318 . - 0 Mb1895c conserved protein Mb1895c, -, len: 251 aa. Equivalent to Rv1864c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Conserved hypothetical protein. Similar to other hypothetical proteins e.g. AL031317|SC6G4.43 from Streptomyces coelicolor cosmid 6G (233 aa), FASTA scores: opt: 716,E(): 0, (54.4% identity in 215 aa overlap); also P43976|YIIM_HAEIN hypothetical protein hi0278 (221 aa),FASTA scores: opt: 223, E(): 3.8e-08, (29.5% identity in 173 aa overlap). Q7TZF1 No conserved hypotheticals Rv1864c NC_002945.3 Mycobrowser_v2 CDS 2245337 2245636 . - 0 Mb2043c CONSERVED HYPOTHETICAL PROTEIN Mb2043c, -, len: 99 aa. Equivalent to Rv2020c, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein, nearly identical to C-terminal part of hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds to deletion region RvD1 so probably truncated protein. Q7TZ53 No conserved hypotheticals Rv2020c NC_002945.3 Mycobrowser_v2 CDS 2102315 2103175 . - 0 Mb1896c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE Mb1896c, -, len: 286 aa. Equivalent to Rv1865c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable short-chain dehydrogenase (EC 1.-.-.-), highly similar to C-terminus of NP_301650.1|NC_00267 putative oxidoreductase from Mycobacterium leprae (596 aa). Also similar to various dehydrogenases, generally belonging to short-chain family,e.g. AAG02168.1|AF212041_24|AF212041 3-oxoacyl-(acylcarrier protein) reductase from Zymomonas mobilis (251 aa); P50198|LINX_PSEPA 2,5-DICHLORO-2,5-CYCLOHEXADIENE-1,4-DIOL DEHYDROGENASE from Sphingomonas paucimobilis (250 aa); NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar to acetoin reductase) from Mesorhizobium loti (256 aa); etc. And highly similar to C-terminus of ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis (592 aa); and many other oxidoreductases from Mycobacterium tuberculosis e.g. Y00P_MYCTU|Q10402 putative oxidoreductase (650 aa), FASTA scores: opt: 439, E(): 8.9e-20, (32.5% identity in 280 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TZF0 No intermediary metabolism and respiration Rv1865c NC_002945.3 Mycobrowser_v2 CDS 2103349 2105685 . + 0 Mb1897 conserved protein Mb1897, -, len: 778 aa. Equivalent to Rv1866, len: 778 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 778 aa overlap). Conserved hypothetical protein, N-terminal region similar to fatty acyl-CoA racemases e.g. Rv0855, Rv1143, and C-terminal region (from aa 370) similar to L-carnitine dehydratases, racemases,and Rv3272|MTCY71.12 Mycobacterium tuberculosis (394 aa),FASTA score: opt: 472, E(): 2.1e-21, (29.9% identity in 388 aa overlap). Also similar to P31572|CAIB_ECOLI L-CARNITINE DEHYDRATASE (EC 4.2.1.89) (405 aa), FASTA score: opt: 306, E(): 2.1e-11, (23.3% identity in 424 aa overlap). Q7TZE9 No lipid metabolism Rv1866 NC_002945.3 Mycobrowser_v2 CDS 2105973 2107457 . + 0 Mb1898 conserved protein Mb1898, -, len: 494 aa. Equivalent to Rv1867, len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 494 aa overlap). Conserved hypothetical protein, some similarity to acetyl CoA synthase and to lipid carriers. FASTA best: E155295 acetyl CoA synthase (388 aa), opt: 213, E(): 4.5e-07, (23.2% identity in 423 aa overlap). Q7TZE8 No lipid metabolism Rv1867 NC_002945.3 Mycobrowser_v2 CDS 2227479 2228336 . - 0 Mb2026c CONSERVED HYPOTHETICAL PROTEIN Mb2026c, -, len: 285 aa. Equivalent to Rv2003c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 285 aa overlap). Conserved hypothetical protein. Some similarity with Methanococcus jannaschii 67555|U67555_3 (205 aa), FASTA scores: opt: 357, E(): 3.2e-17, (33.8% identity in 204 aa overlap). X2BJU1,P64920 No conserved hypotheticals Rv2003c NC_002945.3 Mycobrowser_v2 CDS 2107556 2109655 . + 0 Mb1899 CONSERVED HYPOTHETICAL PROTEIN Mb1899, -, len: 699 aa. Equivalent to Rv1868, len: 699 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 699 aa overlap). Conserved hypothetical protein, similar to products of three consecutive ORFS in Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt: 314,E(): 9.9e-12, (35.2% identity in 213 aa overlap); MLCB2052.17, and MLCB2052.16. Also similar to M. tuberculosis hypothetical protein Rv2047c. Q7TZE7 No conserved hypotheticals Rv1868 NC_002945.3 Mycobrowser_v2 CDS 2109669 2110904 . - 0 Mb1900c Probable reductase Mb1900c, -, len: 411 aa. Equivalent to Rv1869c,len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Probable reductase (1.-.-.-). Similar to several reductases e.g. CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494 rhodocoxin reductase (426 aa), FASTA scores: opt: 904,E(): 0, (40.8% identity in 370 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv0688 (406 aa) (39.9% identity in 391 aa overlap); and Rv0253 (nitrite reductase subunit). Q7VET3 No intermediary metabolism and respiration Rv1869c NC_002945.3 Mycobrowser_v2 CDS 4133018 4133401 . + 0 Mb3773 conserved protein Mb3773, -, len: 127 aa. Equivalent to Rv3747, len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Hypothetical protein,highly similar to downstream ORF O69715|Rv3748|MTV025.096 CONSERVED HYPOTHETICAL PROTEIN (119 aa), FASTA scores: opt: 494, E(): 6e-27, (64.4% identity in 118 aa overlap). Q7TVS6 No conserved hypotheticals Rv3747 NC_002945.3 Mycobrowser_v2 CDS 2110971 2111639 . - 0 Mb1901c CONSERVED HYPOTHETICAL PROTEIN Mb1901c, -, len: 222 aa. Equivalent to Rv1870c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Conserved hypothetical protein. Some similarity to SC6F7.17c hypothetical protein from Streptomyces coelicolor (216 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (t-a) and a single base transition (c-t) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa). Q7TZE6 No conserved hypotheticals Rv1870c NC_002945.3 Mycobrowser_v2 CDS 2111704 2112093 . - 0 Mb1902c conserved protein Mb1902c, -, len: 129 aa. Equivalent to Rv1871c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Q11057|Rv1261|MTCY50.21 (149 aa), FASTA score: opt: 125, E(): 0.019, (32.6% identity in 89 aa overlap); Rv0523c, and Rv1598c. Q7TZE5 No conserved hypotheticals Rv1871c NC_002945.3 Mycobrowser_v2 CDS 2122580 2123413 . - 0 Mb1914c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb1914c, -, len: 277 aa. Equivalent to Rv1882c,len: 277 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 277 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_250789.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (251 aa); NP_421760.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (270 aa); NP_107167.1|NC_002678 oxidoreductase (short chain dehydrogenase/reductase family) from Mesorhizobium loti (253 aa); P50197|LINC_PSEPA 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa), FASTA scores: opt: 301, E(): 2.3e-12, (30.0% identity in 223 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3057c, Rv1245, etc. Contains possible helix-turn-helix motif at aa 246-267 (+4.32 SD). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TZD5 No intermediary metabolism and respiration Rv1882c NC_002945.3 Mycobrowser_v2 CDS 2112116 2113360 . - 0 Mb1903c lldD2 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 Mb1903c, lldD2, len: 414 aa (start uncertain). Equivalent to Rv1872c, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 414 aa overlap). Possible lldD2, L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar to other lactate dehydrogenases and other oxidases e.g. LLDD_ECOLI|P33232 l-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa), FASTA results: opt: 674, E(): 1.1e-37, (40.5% identity in 279 aa overlap); Q51135 LACTATE DEHYDROGENASE from Neisseria meningitidis (390 aa), FASTA results: opt: 309, E(): 4.1e-15, (42.5% identity in 113 aa overlap); etc. Also shows similarity with Rv0694|lldD1|MTCY210.11 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis (396 aa). Contains PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY. Q7TZE4 No intermediary metabolism and respiration Rv1872c NC_002945.3 Mycobrowser_v2 CDS 2114590 2115033 . + 0 Mb1906 conserved protein Mb1906, -, len: 147 aa. Equivalent to Rv1875, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178,E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09, (38.7% identity in 137 aa overlap). Q7TZE1 No conserved hypotheticals Rv1875 NC_002945.3 Mycobrowser_v2 CDS 2115549 2116028 . + 0 Mb1907 bfrA PROBABLE BACTERIOFERRITIN BFRA Mb1907, bfrA, len: 159 aa. Equivalent to Rv1876,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable bfrA,bacterioferritin, similar to BFR_MYCLE|P43315 bacterioferritin (bfr) from Mycobacterium leprae (159 aa),FASTA results: opt: 958, E(): 0, (90.6% identity in 159 aa overlap). Also similar to Rv3841|MTCY01A6.28c|bfrB POSSIBLE BACTERIOFERRITIN from Mycobacterium tuberculosis (181 aa). BELONGS TO THE BACTERIOFERRITIN FAMILY. X2BJ97,P63698 No intermediary metabolism and respiration Rv1876 NC_002945.3 Mycobrowser_v2 CDS 2116113 2117648 . + 0 Mb1908 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [FIRST PART] Mb1908, -, len: 511 aa. Similar to 5' end of Rv1877, len: 687 aa, from Mycobacterium tuberculosis strain H37Rv, (93.2% identity in 292 aa overlap). Probable conserved integral membrane protein, part of major facilitator superfamily (MFS), similar to many antibiotic and drug efflux proteins. Similar to e.g. Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE from Streptomyces violaceoruber (557 aa), FASTA scores: opt: 895, E(): 0, (34.7% identity in 528 aa overlap). Also similar to Mycobacterium tuberculosis relatives protein, include Rv3728, Rv3239c,Rv2846c, etc. Contains PS00217 Sugar transport proteins signature 2 (PS00217). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts,Mb1908 and Mb1909. Q7TZE0 No NC_002945.3 Mycobrowser_v2 CDS 2116963 2118177 . + 0 Mb1909 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [SECOND PART] Mb1909, -, len: 404 aa. Equivalent to 3' end of Rv1877, len: 687 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 404 aa overlap). Probable conserved integral membrane protein, part of major facilitator superfamily (MFS), similar to many antibiotic and drug efflux proteins. Similar to e.g. Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE from Streptomyces violaceoruber (557 aa), FASTA scores: opt: 895, E(): 0,(34.7% identity in 528 aa overlap). Also similar to Mycobacterium tuberculosis relatives protein, include Rv3728, Rv3239c, Rv2846c, etc. Contains PS00217 Sugar transport proteins signature 2 (PS00217). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts, Mb1908 and Mb1909. Q7TZD9 No NC_002945.3 Mycobrowser_v2 CDS 2118232 2119584 . + 0 Mb1910 glnA3 PROBABLE GLUTAMINE SYNTHETASE GLNA3 (GLUTAMINE SYNTHASE) (GS-I) Mb1910, glnA3, len: 450 aa. Equivalent to Rv1878,len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 450 aa overlap). Probable glnA3,glutamine synthetase class I (EC 6.3.1.2), similar to many e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa),FASTA results: opt: 497, E(): 5.2e-23, (29.0% identity in 331 aa overlap); etc. Also similar to C-terminus of FLUG_EMENI|P38094 flug protein from emericella nidulans (865 aa), FASTA scores: opt: 227, E (): 6.4e-13, (29.9% identity in 394 aa overlap). Note that the downstream ORF MTCY180.39c is similar to the N-terminus. Also similar to three other potential glutamine synthases in M. tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427 .03c; Rv2860c|MTV003.06c|glnA4 and Rv2220|glnA1. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY. Q7TZD8 No NC_002945.3 Mycobrowser_v2 CDS 2119587 2120723 . + 0 Mb1911 CONSERVED HYPOTHETICAL PROTEIN Mb1911, -, len: 378 aa. Equivalent to Rv1879, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). Conserved hypothetical protein, similar to SCC22.14c|AL096839 hypothetical protein from Streptomyces coelicolor (368 aa), FASTA results: opt: 772, E(): 0 (40.3% identity in 372 aa overlap); and to N-terminal half of nodulin/glutamate-ammonia ligase-like protein. Some similarity to N-terminus of AL132958|ATT4D2_11 Arabidopsis thaliana (845 aa), FASTA results: opt: 354, E(): 3.1e-16,(29.2% identity in 383 aa overlap); and to P38094|FLUG_EMENI Flug protein of Emericella nidulans (865 aa), FASTA results: opt: 306, E(): 6.2e-13, (26.5% identity in 415 aa overlap). Note that the upstream ORF Rv1878|MTCY18 0.40c is similar to the C-terminus. Q7TZD7 No conserved hypotheticals Rv1879 NC_002945.3 Mycobrowser_v2 CDS 2120751 2122067 . - 0 Mb1912c cyp140 Probable cytochrome p450 140 CYP140 Mb1912c, cyp140, len: 438 aa. Equivalent to Rv1880c, len: 438 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 438 aa overlap). Probable cyp140, cytochrome p450 (EC 1.14.-.-). Similar to Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase (404 aa), FASTA scores: opt: 775, E(): 0, (44.2% identity in 319 aa overlap); and other members of the cytochrome P450 family. Related to Mycobacterium tuberculosis proteins include: Rv0766c, Rv2266, Rv0778, etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. X2BJA3,P63722 No intermediary metabolism and respiration Rv1880c NC_002945.3 Mycobrowser_v2 CDS 2122117 2122539 . - 0 Mb1913c lppE POSSIBLE CONSERVED LIPOPROTEIN LPPE Mb1913c, lppE, len: 140 aa. Equivalent to Rv1881c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap=. Possible lppE,lipoprotein, showing some similarity to L12238|MSG18S19K_1 19K antigen from Mycobacterium intracellulare (162 aa),FASTA scores: opt: 137, E(): 0.0069, (27.6% identity in 156 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TZD6 No NC_002945.3 Mycobrowser_v2 CDS 2123441 2123917 . - 0 Mb1915c CONSERVED HYPOTHETICAL PROTEIN Mb1915c, -, len: 158 aa. Equivalent to Rv1883c,len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(96.8% identity in 158 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins e.g. Rv2778c|AL008967|MTV002.43 from Mycobacterium tuberculosis (156 aa), FASTA score: opt: 212, E(): 3.1e-08, (34.4% identity in 151 aa overlap). Also similar to U75434|SAU75434_3 Nsh-OrfB from Streptomyces actuosus (173 aa), FASTA score: opt: 207, E(): 1.8e-07, (40.2% identity in 102 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa). Q7TZD4 No conserved hypotheticals Rv1883c NC_002945.3 Mycobrowser_v2 CDS 2123956 2124486 . - 0 Mb1916c rpfC PROBABLE RESUSCITATION-PROMOTING FACTOR RPFC Mb1916c, rpfC, len: 176 aa. Equivalent to Rv1884c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Probable rpfC,resuscitation promoting factor (see citation below),similar to Z96935|MLRPF_1 resusicitation-promoting factor from Micrococcus luteus (220 aa), FASTA score: opt: 287,E() : 3.3e-11, (40.0% identity in 120 aa overlap). Also similar to others from Mycobacterium tuberculosis: Rv2389c|MTCY253.32|RPFD PROBABLE RESUSCITATION-PROMOTING FACTOR (154 aa), FASTA score: opt: 382, E(): 7.1e-17,(55.4% identity in 101 aa overlap); Rv0867c|RPFA (N-terminal part), Rv2450c|RPFE, and Rv1009|RPFB (C-terminal part). Q7TZD3 No NC_002945.3 Mycobrowser_v2 CDS 2125115 2126092 . - 0 Mb1918c fbpB secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (Fibronectin-binding protein B) (Extracellular alpha-antigen) Mb1918c, fbpB, len: 325 aa. Equivalent to Rv1886c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 325 aa overlap). fbpB (alternate gene names: mpt59, 85B), precursor of the 85-B antigen (fibronectin-binding protein B) (mycolyl transferase 85B) (EC 2.3.1.-) (see citations below), highly similar to other Mycobacterial antigen precursors e.g. P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from Mycobacterium bovis (323 aa); P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR from Mycobacterium kansasii (325 aa); etc. Also highly similar to Mycobacterium tuberculosis antigen precursors: Rv3804c|fbpA (338 aa), Rv0129c|fbpC2 (340 aa),and Rv3803c|fbpC1 (299 aa). X2BIS9,P0C2T2 No NC_002945.3 Mycobrowser_v2 CDS 2126483 2127625 . + 0 Mb1919 HYPOTHETICAL PROTEIN Mb1919, -, len: 380 aa. Equivalent to Rv1887, len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 380 aa overlap). Hypothetical unknown protein; contains eukaryotic thiol (cysteine) proteases histidine active site at N-terminus (PS00639) and Pro-rich region near C-terminus. Q7TZD1 No conserved hypotheticals Rv1887 NC_002945.3 Mycobrowser_v2 CDS 2247184 2247861 . - 0 Mb2047c HYPOTHETICAL PROTEIN Mb2047c, -, len: 225 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT2080, len: 225 aa, from Mycobacterium tuberculosis strain CDC1551, (100.0% identity in 225 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv. Q7TZ49 No NC_002945.3 Mycobrowser_v2 CDS 2127595 2128314 . - 0 Mb1920c POSSIBLE TRANSMEMBRANE PROTEIN Mb1920c, -, len: 239 aa. Similar to Rv1888c, len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Possible transmembrane protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 10 bp insertion (*-tccgatcacc) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa). Q7TZD0 No NC_002945.3 Mycobrowser_v2 CDS 2128679 2128852 . - 0 Mb1921c CONSERVED HYPOTHETICAL PROTEIN Mb1921c, -, len: 57 aa. Equivalent to Rv1888A, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Conserved hypothetical protein. Possibly continuation of Rv1889c, part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~ 120 aa. Includes: C-terminus of Rv0726c|P95074 CONSERVED HYPOTHETICAL PROTEIN (367 aa), FASTA scores: opt: 295, E(): 3.1e-15,(73.684% identity in 57 aa overlap); C-terminus of Rv3399|Q50726|MTCY78.29c CONSERVED HYPOTHETICAL PROTEIN (348 aa), FASTA scores: opt: 504, E(): 7.3e-29, (64.2% identity in 120 aa overlap); C-terminus of Rv0731c; etc. Q7TZC9 No conserved hypotheticals Rv1888A NC_002945.3 Mycobrowser_v2 CDS 2128896 2129252 . - 0 Mb1922c CONSERVED HYPOTHETICAL PROTEIN Mb1922c, -, len: 118 aa. Equivalent to Rv1889c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein. Part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~ 120 aa. Includes: Rv3399|Q50726|MTCY78.29C hypothetical 38.1 kd protein (348 aa), FASTA results: opt: 504, E(): 7.3e-29, (64.2% identity in 120 aa overlap); Rv0726c, Rv0731c, etc. Q7TZC8 No conserved hypotheticals Rv1889c NC_002945.3 Mycobrowser_v2 CDS 2130974 2132104 . - 0 Mb1927c CONSERVED HYPOTHETICAL PROTEIN Mb1927c, -, len: 376 aa. Equivalent to Rv1894c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Conserved hypothetical protein, weak similarity to some oxidoreductases e.g. Q01284 2-NITROPROPANE DIOXYGENASE PRECURSOR (378 aa), FASTA results: opt: 204, E(): 5.8e-06,(34.3% identity in 140 aa overlap). Similar to hypothetical Mycobacterium tuberculosis proteins e.g. Rv3553|MTCY03C7.02c (355 aa), FASTA results: opt: 296,E(): 1.6e-10, (32.9% identity in 167 aa overlap); Rv1533 (375 aa) (48.1% identity in 376 aa overlap); Rv0021c,Rv2781c. Q7TZC3 No conserved hypotheticals Rv1894c NC_002945.3 Mycobrowser_v2 CDS 2143515 2144162 . - 0 Mb1942c HYPOTHETICAL PROTEIN Mb1942c, -, len: 215 aa. Equivalent to Rv1907c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Hypothetical unknown protein. Similar to Q50763 Ethyl methane sulphonate resistance protein from Mycobacterium tuberculosis (168 aa), FASTA scores: opt: 638, E(): 0, (69.7% identity in 152 aa overlap). Downstream of a cloned katG gene (EMBL:MTKATG). Differences are due to frameshift errors in the EMBL sequence and the use of an earlier start codon. Q7TZB2 No conserved hypotheticals Rv1907c NC_002945.3 Mycobrowser_v2 CDS 2132756 2133079 . + 0 Mb1928 POSSIBLE DEHYDROGENASE [FIRST PART] Mb1928, -, len: 107 aa. Equivalent to 5' end of Rv1895, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 96 aa overlap). Possible dehydrogenase (EC 1.1.-.-), similar to various sorbitol and alcohol dehydrogenases, and to putative glutathione-dependent aldehyde dehydrogenase e.g DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from Streptomyces coelicolor (352 aa), FASTA results: opt: 506, E(): 7.2e-24, (30.6% identity in 350 aa overlap); and AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE from Streptomyces coelicolor (356 aa), FASTA results: opt: 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also similar to other Mycobacterium tuberculosis dehydrogenases. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t),consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929. Q7TZC2 No NC_002945.3 Mycobrowser_v2 CDS 2133076 2133780 . + 0 Mb1929 POSSIBLE DEHYDROGENASE [SECOND PART] Mb1929, -, len: 234 aa. Equivalent to middle part of Rv1895, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 234 aa overlap). Possible dehydrogenase (EC 1.1.-.-), similar to various sorbitol and alcohol dehydrogenases, and to putative glutathione-dependent aldehyde dehydrogenase e.g DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from Streptomyces coelicolor (352 aa), FASTA results: opt: 506, E(): 7.2e-24, (30.6% identity in 350 aa overlap); and AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE from Streptomyces coelicolor (356 aa), FASTA results: opt: 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also similar to other Mycobacterium tuberculosis dehydrogenases. ****Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t),consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929. Q7TZC1 No NC_002945.3 Mycobrowser_v2 CDS 2133770 2134681 . - 0 Mb1931c CONSERVED HYPOTHETICAL PROTEIN Mb1931c, -, len: 303 aa. Equivalent to Rv1896c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Conserved hypothetical protein. Similar to several (14) hypothetical Mycobacterium tuberculosis proteins e.g. Rv0145|MTCI5.19 (317 aa), FASTA results: opt: 720, E(): 0, (41.6% identity in 308 aa overlap); Q10552|YZ21_MYCTU (325 aa), opt: 689,E(): 0, (40.5% identity in 304 aa overlap); Rv0726c,Rv0731c, Rv3399, etc. and to related proteins in other actinomycetes. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions. X2BJ91,Q7TZC0 No conserved hypotheticals Rv1896c NC_002945.3 Mycobrowser_v2 CDS 2135175 2135483 . + 0 Mb1933 CONSERVED HYPOTHETICAL PROTEIN Mb1933, -, len: 102 aa. Equivalent to Rv1898, len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. Q58452 from METHANOCOCCUS JANNASCH II (100 aa), FASTA results: opt: 152, E(): 9.1e-05, (31.5% identity in 92 aa overlap); and AE000771|AE000771_2 from Aquifex aeolicus (157 aa), FASTA results: opt: 246, E(): 3.2e-11, (39.0% identity in 100 aa overlap). X2BJC9 No conserved hypotheticals Rv1898 NC_002945.3 Mycobrowser_v2 CDS 2135449 2136525 . - 0 Mb1934c lppD POSSIBLE LIPOPROTEIN LPPD Mb1934c, lppD, len: 358 aa. Similar to Rv1899c,len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(95.5% identity in 358 aa overlap). Possible lipoprotein; contains appropriately localized lipoprotein lipid attachment site (PS00013). Some similarity to C-terminal part of AE000717|AE000717_4 hypothetical protein from Aquifex aeolicus section 49 (165 aa), FASTA results: opt: 372, E(): 2.3e-14, (43.5% identity in 147 aa overlap); and Q44020 4-hydroxybutyrate dehydrogenase (173 aa), FASTA results: opt: 272, E(): 4.7e-09, (35.8% identity in 165 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa). X2BIV1 No NC_002945.3 Mycobrowser_v2 CDS 2136525 2137913 . - 0 Mb1935c lipJ PROBABLE LIGNIN PEROXIDASE LIPJ Mb1935c, lipJ, len: 462 aa. Equivalent to Rv1900c,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 462 aa overlap). Probable lipJ, lignin peroxidase, with some similarity to esterases, hydrolases and hypothetical Mycobacterium tuberculosis proteins e.g. Q43936 BETA-KETOADIPATE ENOL-LACTONE HYDROLASE from Acinetobacter calcoaceticus (267 aa), FASTA results: opt: 217, E(): 1.7e-07, (29.2% identity in 260 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv2212|Q10400|YM12_MYCTU (378 aa), FASTA results: opt: 216, E(): 6.7e-07, (27.7% identity in 285 aa overlap). Q7TZB8 No NC_002945.3 Mycobrowser_v2 CDS 2137942 2139234 . + 0 Mb1936 cinA PROBABLE CINA-LIKE PROTEIN CINA Mb1936, cinA, len: 430 aa. Equivalent to Rv1901,len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 430 aa overlap). Probable cinA-like protein, strong similarity to competence damage proteins CinA of Bacillus subtilis and S. pneumoniae. FASTA results: Q55760 HYPOTHETICAL 44.7 KD PROTEIN (416 aa) opt: 755, E(): 0, (36.0% identity in 433 aa overlap). X2BJ98,P63776 No virulence, detoxification, adaptation Rv1901 NC_002945.3 Mycobrowser_v2 CDS 2139286 2140554 . - 0 Mb1937c nanT PROBABLE SIALIC ACID-TRANSPORT INTEGRAL MEMBRANE PROTEIN NANT Mb1937c, nanT, len: 422 aa. Equivalent to Rv1902c,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Probable nanT, sialic acid-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. Q48076 SIALIC ACID TRANSPORTER (407 aa), FASTA results: opt: 443, E(): 5.4e-22, (26.7% identity in 389 aa overlap); etc. Some similarity to MTCI364.12|O05301 conserved hypothetical protein from Mycobacterium tuberculosis (425 aa), FASTA results: opt: 251, E(): 1.1e-09, (23.5% identity in 417 aa overlap). Contains sugar transport proteins signature 2 (PS00217). Q7TZB7 No NC_002945.3 Mycobrowser_v2 CDS 2140644 2141048 . + 0 Mb1938 PROBABLE CONSERVED MEMBRANE PROTEIN Mb1938, -, len: 134 aa. Equivalent to Rv1903, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Probable conserved membrane protein, similar to Q53868|YPT3_STRCO hypothetical 15.9 kd protein from Streptomyces coelicolor (148 aa) opt: 323, E(): 1.3e-16, (42.9% identity in 126 aa overlap); and equivalent to AJ000521|MLCOSL672_3 from Mycobacterium leprae (139 aa), FASTA results: opt: 680,E(): 0, (80.6% identity in 129 aa overlap). Q7TZB6 No cell wall and cell processes Rv1903 NC_002945.3 Mycobrowser_v2 CDS 2141234 2141665 . + 0 Mb1939 CONSERVED HYPOTHETICAL PROTEIN Mb1939, -, len: 143 aa. Equivalent to Rv1904, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 143 aa overlap). Conserved hypothetical protein, some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt: 456, E( ): 2.7e-23, (52.8% identity in 125 aa overlap); Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E(): 1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c. Also weak similarity to Q9WVX8|RSBV_STRCO ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa). Q7TZB5 No conserved hypotheticals Rv1904 NC_002945.3 Mycobrowser_v2 CDS 2141713 2142675 . - 0 Mb1940c aao probable d-amino acid oxidase aao Mb1940c, aao, len: 320 aa. Equivalent to Rv1905c,len: 320 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 320 aa overlap). Probable aao, D-amino acid oxidase (EC 1.4.3.3), similar to many. Equivalent to AJ000521|MLCOSL672.02|O33145 Mycobacterium leprae (320 aa), FASTA results: opt: 1541, E(): 0, (71.7% identity in 315 aa overlap); also similar to OXDD_BOVIN|P31228 d-aspartate oxidase (EC 1.4.3.1) from bos taurus (338 aa),FASTA results: opt: 461, E(): 1.1e-21, (31.8% identity in 321 aa overlap). Q7TZB4 No NC_002945.3 Mycobrowser_v2 CDS 2144169 2146391 . - 0 Mb1943c katG CATALASE-PEROXIDASE-PEROXYNITRITASE T KATG Mb1943c, katG, len: 740 aa. Equivalent to Rv1908c,len: 740 aa, from Mycobacterium tuberculosis strain H37Rv (99.9% identity in 740 aa overlap). katG,catalase-peroxidase-peroxynitritase T (EC 1.11.1.6) (see citations below), HPI. FASTA results: Q57215 CATALASE-PEROXIDASE from Mycobacterium tuberculosis (740 aa) opt: 5081, E(): 0, (100% identity in 740 aa overlap). Contains peroxidases active site signature (PS00436) and ATP/GTP-binding site motif A (P-loop; PS00017). Cosmid sequence was corrected to agree with a sequencing read from the H37Rv genome. DELETIONS OR DEFECTS IN KATG GENE CAUSE ISONIAZID (INH) RESISTANCE. BELONGS TO THE PEROXIDASE FAMILY. BACTERIAL PEROXIDASE/CATALASE SUBFAMILY. KATG TRANSCRIPTION SEEMS TO BE REGULATED BY FURA|Rv1909c PRODUCT. The catalase-peroxidase activity is associated with the amino-terminal domain but no definite function has been assigned to the carboxy-terminal domain. X2BJE1,P46817 No NC_002945.3 Mycobrowser_v2 CDS 2146429 2146872 . - 0 Mb1944c furA Ferric uptake regulation protein FurA (fur) Mb1944c, len: 147 aa. Equivalent to Rv1909c len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). FurA, Ferric uptake regulation protein, similar to Q48835 legionella pneumophila 130B (wadsworth) ferric uptake regulation (136 aa), FASTA results: opt: 230, E(): 2.5e-09, (32.3% identity in 133 aa overlap). Also similar to Mycobacterium tuberculosis zur zinc uptake regulatory protein, Rv2359. Belongs to the fur family. Start changed since original submission (-3 aa). X2BIW7,P0A583 No regulatory proteins Rv1909c NC_002945.3 Mycobrowser_v2 CDS 2147662 2148267 . - 0 Mb1946c lppC PROBABLE LIPOPROTEIN LPPC Mb1946c, lppC, len: 201 aa. Equivalent to Rv1911c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable lipoprotein lppC, contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS00013). Very similar to downstream ORF MTCY180.08 (204 aa) (although this lacks lipoprotein motif), FASTA score: opt: 831, E(): 0, (64.0% identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN HYPOTHETICAL PROTEIN CPN0877 from Chlamydia pneumoniae (strain CWL029) (150 aa). X2BJB0 No NC_002945.3 Mycobrowser_v2 CDS 2148367 2149371 . - 0 Mb1947c fadB5 POSSIBLE OXIDOREDUCTASE FADB5 Mb1947c, fadB5, len: 334 aa. Equivalent to Rv1912c,len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 334 aa overlap). Possible fadB5,oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35), quinone oxidoreductases (EC 1.6.5.5), and polyketide synthases, e.g. NP_104067.1|NC_002678 probable oxidoreductase from Mesorhizobium loti (308 aa); NP_464140.1|NC_003210 protein similar to oxidoreductase from Listeria monocytogenes (313 aa); NP_193889.1|NC_003075 putative NADPH quinone oxidoreductase from Arabidopsis thaliana (325 aa); NP_001880.2|NM_001889 crystallin, zeta; quinone oxidoreductase; NADPH:quinone reductase from Homo sapiens (329 aa); part 2983 to 3197 of T17410 polyketide synthase type I from Streptomyces venezuelae (3739 aa); Q53927|SCBAC20F6.16 HYDROXYACYL-COA DEHYDROGENASE from Streptomyces coelicolor (329 aa), FASTA scores: opt: 621,E(): 2e-30, (39.5% identity in 349 aa overlap); etc. Also similar to many hypothetical Mycobacterium tuberculosis proteins including: MTCY24G1.09, MTCY13D12.11,MTCY19H9.01, MTCY24G1.03, MTCY03A2.17c, etc. Contains quinone oxidoreductase/zeta-crystallin signature (PS01162). Q7TZB1 No NC_002945.3 Mycobrowser_v2 CDS 2149471 2150223 . + 0 Mb1948 CONSERVED HYPOTHETICAL PROTEIN Mb1948, -, len: 250 aa. Equivalent to Rv1913, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Conserved hypothetical protein, slight similarity to dehydrase and beta-lactamase precursors e.g. Q02057 DEHYDRASE from Streptomyces coelicolor (297 aa), FASTA scores: opt: 184,E(): 4.3e-05, (31.6% identity in 215 aa overlap). Q7TZB0 No conserved hypotheticals Rv1913 NC_002945.3 Mycobrowser_v2 CDS 2150201 2150608 . - 0 Mb1949c unknown protein Mb1949c, -, len: 135 aa. Equivalent to Rv1914c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Hypothetical unknown protein. Q7TZA9 No conserved hypotheticals Rv1914c NC_002945.3 Mycobrowser_v2 CDS 2172897 2173541 . - 0 Mb1964c CONSERVED HYPOTHETICAL PROTEIN Mb1964c, -, len: 214 aa. Equivalent to Rv1929c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(99.533% identity in 214 aa overlap). Conserved hypothetical protein, similar to SC4G6.14|AL096884 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 416, E(): 2.4e-22, (39.8% identity in 206 aa overlap). I3NIG2 No conserved hypotheticals Rv1929c NC_002945.3 Mycobrowser_v2 CDS 2150743 2153043 . + 0 Mb1950 aceA probable isocitrate lyase aceab [second part] (isocitrase) (isocitratase) (icl) Mb1950, aceA, len: 766 aa. Similar to Rv1915 and Rv1916, len: 367 aa and 398 aa, from Mycobacterium tuberculosis strain H37Rv, (89.1% identity in 339 aa overlap and 100.0% identity in 398 aa overlap). Probable aceA, isocitrate lyase (EC 4.1.3.1). Contains PS00161 Isocitrate lyase signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-t) leads to a single product. Q7TZA8 No NC_002945.3 Mycobrowser_v2 CDS 2153213 2158945 . - 0 Mb1951c PPE34 ppe family protein ppe34 Mb1951c, PPE34, len: 1910 aa. Similar to Rv1917c,len: 1459 aa, from Mycobacterium tuberculosis strain H37Rv. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, MPTR subfamily (see citation below). Similar to MTCY28.16, MTCY13E10.17, MTCY63.10,MTV004.05 , MTCY98.24, MTCY6G11.05, etc. C-terminus is identical to Q50471. Unknown Mycobacterium tuberculosis protein (693 aa), FASTA results: opt: 2635, E(): 0, (99.7% identity in 391 aa overlap). Start changed since original submission (+23 aa). Thougth to be surface exposed,cell-wall associated. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, deletions of 12 bp and 69 bp,insertions of 483 bp and 375 bp, and a large substitution of 52 bp to 628 bp, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1910 aa versus 1459 aa). Q7TZA7 No NC_002945.3 Mycobrowser_v2 CDS 2159283 2160287 . - 0 Mb1952c PPE35b PPE FAMILY PROTEIN Mb1952c, PPE35b, len: 334 aa. Equivalent to 3' end of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis strain H37Rv, (99.1% identity in 334 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 M. tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404,E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23,MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36,MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts,PPE35a and PPE35b. No NC_002945.3 Mycobrowser_v2 CDS 2160370 2162247 . - 0 Mb1953c PPE35a PPE FAMILY PROTEIN Mb1953c, PPE35a, len: 625 aa. Equivalent to 5'end of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 599 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 M. tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404,E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23,MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36,MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts,PPE35a and PPE35b. Q7TZA6 No NC_002945.3 Mycobrowser_v2 CDS 2162696 2163160 . - 0 Mb1954c conserved protein Mb1954c, -, len: 154 aa. Equivalent to Rv1919c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Conserved hypothetical protein, shows weak similarity to several major pollen antigens e.g. Z72431|BVGC25_1 MAJOR ALLERGEN BET V 1 from Betula verrucosa (160 aa), FASTA scores: opt: 133, E(): 0.012, (26.8% identity in 149 aa overlap). Also shows some similarity to Rv2574|MTCY227.27C Hypothetical protein from Mycobacterium tuberculosis (167 aa), (27.4% identity in 124 aa overlap). Q7TZA5 No conserved hypotheticals Rv1919c NC_002945.3 Mycobrowser_v2 CDS 2163258 2164121 . + 0 Mb1955 PROBABLE MEMBRANE PROTEIN Mb1955, -, len: 287 aa. Equivalent to Rv1920, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). Probable membrane protein, similar to AL0215|SC10A5.04 putative membrane protein from Streptomyces coelicolor cosmid 10A5 (295 aa),FASTA scores: opt: 292, E(): 3.6e-13, (31.3% identity in 243 aa overlap). Also weakly similar to several Mycobacterial putative proteins with unknown function e.g. Rv0502, Rv1428c, U00018_22 Mycobacterium leprae cosmid B2168. Q7TZA4 No cell wall and cell processes Rv1920 NC_002945.3 Mycobrowser_v2 CDS 2164159 2165430 . - 0 Mb1956c lppF PROBABLE CONSERVED LIPOPROTEIN LPPF Mb1956c, lppF, len: 423 aa. Equivalent to Rv1921c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 423 aa overlap). Probable lppF,conserved lipoprotein, similar to G403173 lipoprotein precursor (fragment) from Rhodococcus erythropolis (225 aa), fasta scores: opt: 364, E(): 9.2e-19, (41.9% identity in 148 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TZA3 No NC_002945.3 Mycobrowser_v2 CDS 2165702 2166817 . + 0 Mb1957 PROBABLE CONSERVED LIPOPROTEIN Mb1957, -, len: 371 aa. Equivalent to Rv1922, len: 371 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 371 aa overlap). Probable conserved lipoprotein, possibly peptidase (EC 3.4.-.-) similar to many peptidases, e.g. P15555|DAC_STRSQ D-alanyl-D-alanine carboxypeptidase from Streptomyces sp. (406 aa), FASTA scores: opt: 382, E(): 3.1e-17, (28.0% identity in 379 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TZA2 No cell wall and cell processes Rv1922 NC_002945.3 Mycobrowser_v2 CDS 2166808 2168148 . + 0 Mb1958 lipD PROBABLE LIPASE LIPD Mb1958, lipD, len: 446 aa. Equivalent to Rv1923,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 446 aa overlap). Probable lipD,hydrolase lipase (EC 3.1.-.-), similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569, E(): 5.4e-29, (33.7% identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. Q7TZA1 No intermediary metabolism and respiration Rv1923 NC_002945.3 Mycobrowser_v2 CDS 2168185 2168565 . - 0 Mb1959c unknown protein Mb1959c, -, len: 126 aa. Equivalent to Rv1924c,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Hypothetical unknown protein. Q7TZA0 No conserved hypotheticals Rv1924c NC_002945.3 Mycobrowser_v2 CDS 2168722 2170584 . + 0 Mb1960 fadD31 PROBABLE ACYL-COA LIGASE FADD31 (ACYL-COA SYNTHETASE) (ACYL-COA SYNTHASE) Mb1960, fadD31, len: 620 aa. Equivalent to Rv1925,len: 620 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 620 aa overlap). Probable fadD31,acyl-CoA synthetase (EC 6.2.1.-), highly similar to others from Mycobacterium leprae e.g. NP_301198.1|NC_002677 putative acyl-CoA synthetase (635 aa); NP_302537.1|NC_002677 probable acyl-CoA synthase (583 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD32 (637 aa); fadD21 (578 aa); fadD29 (619 aa); fadD26|FD26_MYCTU|Q10976 (626 aa), FASTA scores: opt: 945, E(): 0, (39.8% identity in 598 aa overlap); etc. Also similar to N-terminus of G1171128 SAFRAMYCIN MX1 SYNTHETASE B from Myxococcus xanthus (1770 aa), FASTA scores: opt: 845, E(): 0, (37.4% identity in 593 aa overlap); N-terminus of T34918 polyketide synthase from Streptomyces coelicolor (2297 aa); etc. Q7TZ99 No NC_002945.3 Mycobrowser_v2 CDS 2298267 2298572 . - 0 Mb2082c rpsN2 30s ribosomal protein s14 rpsn2 Mb2082c, rpsN2, len: 101 aa. Equivalent to Rv2056c,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Probable rpsN2,ribosomal protein S14, similar to others e.g. RS14_ECOLI|P02370 30S ribosomal protein S14 from Escherichia coli (100 aa), FASTA scores: opt: 290; E(): 1.7e- 13; (46.0% identity in 100 aa overlap); etc. Also similar to rpsN|Rv0717|MTCY210.36 from Mycobacterium tuberculosis, (50.0% identity in 62 aa overlap). X2BJM0,P66406 No NC_002945.3 Mycobrowser_v2 CDS 2170592 2171071 . - 0 Mb1961c mpt63 immunogenic protein mpt63 (antigen mpt63/mpb63) (16 kda immunoprotective extracellular protein) Mb1961c, mpt63, len: 159 aa. Equivalent to Rv1926c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). mpt63 (alternate gene name: mpb63), immunogenic protein (see citations below),identical to MPT63|MPB63 from Mycobacterium bovis (159 aa). Exported protein containing a N-terminal signal sequence: see notes below about proteomics. X2BJC5,P0A5Q3 No NC_002945.3 Mycobrowser_v2 CDS 2171308 2172081 . + 0 Mb1962 CONSERVED HYPOTHETICAL PROTEIN Mb1962, -, len: 257 aa. Equivalent to Rv1927, len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Conserved hypothetical protein, similar to SCG11A.10c|AL133210 hypothetical protein from Streptomyces coelicolor (252 aa), FASTA scores: opt: 729, E(): 0, (48.3% identity in 238 aa overlap). Slight similarity with P54543|YQJF_BACSU hypothetical 23.9 kd protein from Bacillus subtilis (209 aa), FASTA scores, opt: 230, E(): 2.8e-08, (28.0% identity in 164 aa overlap). Q7TZ98 No conserved hypotheticals Rv1927 NC_002945.3 Mycobrowser_v2 CDS 2172085 2172852 . - 0 Mb1963c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb1963c, -, len: 255 aa. Equivalent to Rv1928c,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to others e.g. NP_228109.1|NC_000853 oxidoreductase (short chain dehydrogenase/reductase family) from Thermotoga maritima (257 aa); T41116 short chain dehydrogenase from Schizosaccharomyces pombe (261 aa); P87219|SOU1_CANAL SORBITOL UTILIZATION PROTEIN (SDR FAMILY) from Candida albicans (281 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 541, E(): 1.2e-27, (37.5% identity in 251 aa overlap); etc. Also similar to many mycobacterial tuberculosis proteins e.g. Rv1350, Rv0927c,Rv2002, Rv0769, Rv2766c, etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TZ97 No intermediary metabolism and respiration Rv1928c NC_002945.3 Mycobrowser_v2 CDS 2173553 2174077 . - 0 Mb1965c CONSERVED HYPOTHETICAL PROTEIN Mb1965c, -, len: 174 aa. Equivalent to Rv1930c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 174 aa overlap). Conserved hypothetical protein, similar to SC5F2A.30|AL049587 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 307, E(): 2.8e-13, (54.8% identity in 84 aa overlap). Some similarity to M. tuber culosis hypothetical protein Rv0052|MTCY21D4.15 (43% identity in 93 aa overlap). I3NIF3 No conserved hypotheticals Rv1930c NC_002945.3 Mycobrowser_v2 CDS 2174095 2174874 . - 0 Mb1966c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1966c, -, len: 259 aa. Equivalent to Rv1931c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Probable transcriptional regulatory protein. Similarity in C-terminal half to transcriptional activators e.g. Q43970 ARAC-LIKE PROTEIN (227 aa), FASTA scores: opt: 238, E(): 7.1e-07, (42.4% identity in 92 aa overlap). Similar to many probable transcription regulators in Streptomyces e.g. AL049587|SC5F2A.29 Streptomyces coelicolor (325 aa),FASTA scores: opt: 387, E(): 3.2e-16, (34.4% identity in 259 aa overlap). I3NIF7 No regulatory proteins Rv1931c NC_002945.3 Mycobrowser_v2 CDS 2298574 2298738 . - 0 Mb2083c rpmG1 50s ribosomal protein l33 rpmg1 Mb2083c, rpmG1, len: 54 aa. Equivalent to Rv2057c,len: 54 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 54 aa overlap). Probable rpmG1,ribosomal protein L33. FASTA results: RL33_ECOLI P02436 50S ribosomal protein L33 (54 aa) opt: 183; E(): 1.6e-09; 51.0% identity in 49 aa overlap. Note that previously known as rpmG. X2BJX5,P0A5W1 No NC_002945.3 Mycobrowser_v2 CDS 2175007 2175504 . + 0 Mb1967 tpx PROBABLE THIOL PEROXIDASE TPX Mb1967, tpx, len: 165 aa. Equivalent to Rv1932,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Probable tpx (alternate gene name: cfp20), thiol peroxidase (EC 1.11.1.-) similar to TPX_ECOLI|P37901 thiol peroxidase (EC 1.11.1.-) (p20) from Escherichia coli (167 aa), fasta scores: opt: 535, E(): 7.3e-25, (52.4% identity in 164 aa overlap). There are four other related enzymes in M. tuberculosis: Rv2428, Rv2521, Rv2238c, Rv1608c. X2BJP5,P66953 No virulence, detoxification, adaptation Rv1932 NC_002945.3 Mycobrowser_v2 CDS 2248256 2249152 . - 0 Mb2048c HYPOTHETICAL PROTEIN Mb2048c, -, len: 298 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT2081, len: 311 aa, from Mycobacterium tuberculosis strain CDC1551, (99.66% identity in 298 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv. Q7TZ48 No NC_002945.3 Mycobrowser_v2 CDS 2175501 2176592 . - 0 Mb1968c fadE18 PROBABLE ACYL-COA DEHYDROGENASE FADE18 Mb1968c, fadE18, len: 363 aa. Equivalent to Rv1933c, len: 363 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 363 aa overlap). Probable fadE18, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (362 aa); NP_421282.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (344 aa); ACDS_RAT|P15651 short-chain specific acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 aa), fasta scores: opt: 239, E(): 2.1e-08, (28.4% identity in 331 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. N-terminus of fadE22 (721 aa); fadE33 (318 aa); N-terminus of fadE34 (711 aa); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. I3NIG1 No lipid metabolism Rv1933c NC_002945.3 Mycobrowser_v2 CDS 2176594 2177823 . - 0 Mb1969c fadE17 PROBABLE ACYL-COA DEHYDROGENASE FADE17 Mb1969c, fadE17, len: 409 aa. Equivalent to Rv1934c, len: 409 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 409 aa overlap). Probable fadE17, acyl-CoA dehydrogenase (EC 1.3.99.-),highly similar to ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium leprae (389 aa), FASTA scores: opt: 414, E(): 2.6e-19, (28.3% identity in 407 aa overlap). Also similar to many e.g. NP_249713.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (381 aa); NP_420614.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (355 aa); CAB61610.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (393 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE30 (385 aa); fadE31 (377 aa); C-terminus of fadE34 (711 aa); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. I3NIG0 No lipid metabolism Rv1934c NC_002945.3 Mycobrowser_v2 CDS 2177838 2178794 . - 0 Mb1970c echA13 POSSIBLE ENOYL-COA HYDRATASE ECHA13 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb1970c, echA13, len: 318 aa. Equivalent to Rv1935c, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 318 aa overlap). Possible echA13, enoyl-CoA hydratase (EC 4.2.1.17),similar to others and various enzymes e.g. CAC48381.1|Y16952 putative enoyl-CoA-isomerase from Amycolatopsis mediterranei (269 aa); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa); AAF78820.1|AF042490 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. TM1 (276 aa); ECHM_RAT|P14604 enoyl-coa hydratase mitochondrial precursor from Rattus norvegicus (Rat) (290 aa), FASTA scores: opt: 228, E( ): 1.2e-08, (31.0% identity in 258 aa overlap); etc. I3NIF9 No lipid metabolism Rv1935c NC_002945.3 Mycobrowser_v2 CDS 2179019 2180128 . + 0 Mb1971 POSSIBLE MONOOXYGENASE Mb1971, -, len: 369 aa. Equivalent to Rv1936, len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Possible monooxygenase (EC 1.-.-.-), similar to LXA2_PHOLU|P23146 alkanal monooxygenase alpha chain (362 aa), FASTA scores: opt: 196, E(): 6.3e-06, (22.3% identity in 373 aa overlap). Also similar to many other Mycobacterium tuberculosis hypothetical oxidoreductases and monooxygenases e.g. Rv0953c, Rv0791c, Rv0132c, etc. Q7TZ96 No intermediary metabolism and respiration Rv1936 NC_002945.3 Mycobrowser_v2 CDS 2195315 2195611 . - 0 Mb1994c pare1 possible toxin pare1 Mb1994c, -, len: 98 aa. Equivalent to Rv1959c, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Conserved hypothetical protein, similar to other hypothetical plasmid proteins e.g. AL117189|YPCD1.08 from Yersinia pestis (99 aa), FASTA scores: opt: 162, E(): 7.3e-05, (33.0% identity in 91 aa overlap); also some similarity to E145339 hypothetical protein (103 aa), FASTA scores: opt: 142, E(): 0.0003,(33.0% identity in 91 aa overlap). Q7TZ73 No virulence, detoxification, adaptation Rv1959c NC_002945.3 Mycobrowser_v2 CDS 2180131 2182650 . + 0 Mb1972 POSSIBLE OXYGENASE Mb1972, -, len: 839 aa. Equivalent to Rv1937, len: 839 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 839 aa overlap). Possible oxygenase (EC 1.-.-.-), similar in N-terminus to N-terminal part (approx. 350 aa) of dioxygenases (including ring-hydroxylating dioxygenase electron transfer components) and monooxygenases, e.g. AAC34815.1|AF071556 anthranilate dioxygenase reductase from Acinetobacter sp. (343 aa); AAK52291.1|AY026914|AntC putative anthranilate dioxygenase reductase from Pseudomonas putida (340 aa); AAF63450.1|AF218267_7|AF218267 benzoate dioxygenase / ferredoxin reductase from Pseudomonas putida (336 aa); P23101|XYLZ_PSEPU toluate 1,2-dioxygenase electron transfer component [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE (EC 1.18.1.3)] from Pseudomonas putida plasmid TOL pWW0 (336 aa), FASTA scores: opt: 700, E(): 0, (34.3% identity in 335 aa overlap); S23479 probable benzoate 1,2-dioxygenase (EC 1.14.12.10) reductase component benC from Acinetobacter calcoaceticus (338 aa); AAC45294.1|U81594 soluble methane monooxygenase protein C from Methylocystis sp. (343 aa); P22868|MEMC_METCA METHANE MONOOXYGENASE COMPONENT C from Methylococcus capsulatus (348 aa); etc. Also similar in part to Mycobacterium tuberculosis hypothetical electron transfer proteins Rv3554, Rv3571, etc. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. Q7TZ95 No intermediary metabolism and respiration Rv1937 NC_002945.3 Mycobrowser_v2 CDS 2182662 2183732 . + 0 Mb1973 ephB PROBABLE EPOXIDE HYDROLASE EPHB (EPOXIDE HYDRATASE) Mb1973, ephB, len: 356 aa. Equivalent to Rv1938,len: 356 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Probable ephB,epoxide hydrolase (EC 3.3.2.3) (see citation below),similar to many e.g. G1109600 ATSEH (EC 3.3.2.3) (321 aa),FASTA scores: opt: 442, E(): 1.2e-21 (33.1% identity in 356 aa overlap); etc. Also similar to many other M. tuberculosis hypothetical epoxide hydrolases e.g. Rv3617,Rv3670, Rv0134, etc. Q7TZ94 No virulence, detoxification, adaptation Rv1938 NC_002945.3 Mycobrowser_v2 CDS 2187623 2188987 . + 0 Mb1980 CONSERVED HYPOTHETICAL PROTEIN Mb1980, -, len: 454 aa. Equivalent to Rv1945, len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(99.780% identity in 454 aa overlap). Member of Mycobacterium tuberculosis REP13E12 repeat family. Similar to several others, best with Rv1148c|Z95584|MTCI65.15 (482 aa), FASTA score: opt: 2954, E(): 0, (97.1% identity in 454 aa overlap). Contains possible helix-turn-helix motif at aa 74-95 (+2.90 SD). Q7TZ87 No insertion seqs and phages Rv1945 NC_002945.3 Mycobrowser_v2 CDS 2183729 2184463 . + 0 Mb1974 PROBABLE OXIDOREDUCTASE Mb1974, -, len: 244 aa. Similar to Rv1939, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 167 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to NP_302637.1|NC_002677 probable oxidoreductase from Mycobacterium leprae (162 aa) Also similar to NTAB_CHELE|P54990 nitrilotriacetate monooxygenase component from Chelatobacter heintzii (322 aa), fasta scores: opt: 269, E(): 5.3e-11, (33.1% identity in 151 aa overlap). And similar to Mycobacterium tuberculosis probable monooxygenase components Rv0246,Rv3567, and to a lesser extent, Rv3007c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (t-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (244 aa versus 171 aa). Q7TZ93 No NC_002945.3 Mycobrowser_v2 CDS 2184240 2185301 . + 0 Mb1975 ribA1 Probable Riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) Mb1975, ribA1, len: 353 aa. Equivalent to Rv1940,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 353 aa overlap). Probable ribA1,Riboflavin biosynthesis protein (EC 3.5.4.25), similar to GCH2_BACSU|P17620 gtp cyclohydrolase ii (EC 3.5.4.25) (398 aa), FASTA scores: opt: 682, E(): 0, (37.7% identity in 363 aa overlap), also similar to Rv1415|MTCY21B4.33|ribA2 (428 aa) (45.4% identity in 368 aa overlap). Note that previously known as ribA. Q7TZ92 No NC_002945.3 Mycobrowser_v2 CDS 2185298 2186068 . + 0 Mb1976 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb1976, -, len: 256 aa. Equivalent to Rv1941, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_299015.1|NC_002488 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from Xylella fastidiosa (255 aa); NP_250340.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa); NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa) (has its N-terminus longter); P50197|LINC_PSEPA 2,5-dichloro-2,5-cyclohexadiene-1,4-dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa), FASTA scores: opt: 529, E(): 5.7e-25, (40.6% identity in 251 aa overlap); etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TZ91 No intermediary metabolism and respiration Rv1941 NC_002945.3 Mycobrowser_v2 CDS 2186278 2186607 . - 0 Mb1977c mazf5 possible toxin mazf5 Mb1977c, -, len: 109 aa. Equivalent to Rv1942c,len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Conserved hypothetical protein, shows some similarity to Q10867|MTCY39.28|Rv1991 hypothetical 12.3 kd protein (114 aa), FASTA scores: opt: 117, E(): 0.021, (24. 5% identity in 110 aa overlap) also P33645|CHPA_ECOLI pemk-like protein 1 (mazf protein) from Escherichia coli (111 aa),FASTA scores: opt: 104, E(): 0.18, (29.1% identity in 110 aa overlap). Also similar to Mycobacterium tuberculosis Rv0659c (102 aa) (32.7% identity in 101 aa overlap); Rv1102c (33.3% identity in 93 aa overlap) and Rv1495. Q7TZ90 No virulence, detoxification, adaptation Rv1942c NC_002945.3 Mycobrowser_v2 CDS 2189142 2189594 . - 0 Mb1981c lppG POSSIBLE LIPOPROTEIN Mb1981c, lppG, len: 150 aa. Equivalent to Rv1946c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TZ86 No NC_002945.3 Mycobrowser_v2 CDS 2190709 2191611 . - 0 Mb1984c CONSERVED HYPOTHETICAL PROTEIN Mb1984c, -, len: 300 aa. Equivalent to Rv1949c,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 300 aa overlap). Conserved hypothetical protein, partial ORF. Rv1949c and Rv1950c|MTCY09F9.14 are similar but frameshifted with respect to Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd protein (323 aa), FASTA scores: opt: 459, E(): 2.8e-16, (54.8% identity in 157 aa overlap). Cosmid sequence appears to be correct, genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97. Similar to M. tuberculosis hypothetical proteins: Rv2542, Rv2077c,Rv2797c, Rv0963c, etc. Q7TZ83 No conserved hypotheticals Rv1949c NC_002945.3 Mycobrowser_v2 CDS 2191632 2191823 . - 0 Mb1985c CONSERVED HYPOTHETICAL PROTEIN Mb1985c, -, len: 63 aa. Equivalent to Rv1950c, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Conserved hypothetical protein, partial ORF. Highly similar to N-terminus of Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd protein (323 aa), FASTA scores: opt: 280, E(): 1.2 e-16, (71.7% identity in 53 aa overlap) but homology continues in different frame ie MTCY09F9.15, cosmid sequence appears to be correct, genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97. Q7TZ82 No conserved hypotheticals Rv1950c NC_002945.3 Mycobrowser_v2 CDS 2191824 2192120 . - 0 Mb1986c CONSERVED HYPOTHETICAL PROTEIN Mb1986c, -, len: 98 aa. Equivalent to Rv1951c, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2541 (135 aa) (40.9% identity in 88 aa overlap). Q7TZ81 No conserved hypotheticals Rv1951c NC_002945.3 Mycobrowser_v2 CDS 2192360 2192575 . + 0 Mb1987 vapb14 possible antitoxin vapb14 Mb1987, -, len: 71 aa. Equivalent to Rv1952, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Conserved hypothetical protein. Some similarity to P55510|Y4JJ_RHISN PUTATIVE PLASMID STABILITY PROTEIN (85 aa), FASTA scores: opt: 127,E(): 0.00096, (42.5% identity in 73 aa overlap). Q7TZ80 No virulence, detoxification, adaptation Rv1952 NC_002945.3 Mycobrowser_v2 CDS 2192572 2192883 . + 0 Mb1988 vapc14 possible toxin vapc14 Mb1988, -, len: 103 aa. Equivalent to Rv1953, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Conserved hypothetical protein. Some similarity to O33827 PLASMID STABILITY-LIKE PROTEIN from Thiobacillus ferrooxidans (143 aa), FASTA scores: opt: 170, E(): 3.5e-06, (45.3% identity in 75 aa overlap). Q7TZ79 No virulence, detoxification, adaptation Rv1953 NC_002945.3 Mycobrowser_v2 CDS 2192911 2193213 . + 0 Mb1988A Hypothetical protein Mb1988A, len: 100 aa. Equivalent to Rv1954A len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 100 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Hypothetical unknown protein. X2BJQ1 No unknown Rv1954A NC_002945.3 Mycobrowser_v2 CDS 2213221 2213565 . - 0 Mb2014c mazf6 toxin mazf6 Mb2014c, -, len: 114 aa. Equivalent to Rv1991c,len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Conserved hypothetical protein, showing some similarity to P13976|PEMK_ECOLI pemk protein (133 aa), FASTA scores: opt: 113, E(): 0.043, (29.2% identity in 113 aa overlap); and P96622|YDCE PROTEIN from Bacillus subtilis (116 aa),FASTA scores: opt: 227, E(): 6.9e-09, (37.4% identity in 115 aa overlap). Also similar to Mycobacterium tuberculosis Rv2801c, and Rv0659c. X2BJU0,P64912 No virulence, detoxification, adaptation Rv1991c NC_002945.3 Mycobrowser_v2 CDS 2197216 2198436 . - 0 Mb1998c mce3r probable transcriptional repressor (probably tetr-family) mce3r Mb1998c, -, len: 406 aa. Equivalent to Rv1963c,len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable transcriptional regulatory protein, similar to several e.g. AL049485|SC6A5.30 Streptomyces coelicolor cosmid 6 A (404 aa), FASTA scores: opt: 319, E(): 6.4e-13, (29.5% identity in 373 aa overlap); and Z84498|MTCY9F9_1 (259 aa), FASTA scores: opt: 208, E(): 1.6e-07, (100.0% identity in 32 aa overlap). Contains probable helix-turn-helix at aa 36-57 (+4.23 SD). Q7TZ70 No regulatory proteins Rv1963c NC_002945.3 Mycobrowser_v2 CDS 2199335 2199739 . + 0 Mb1999 yrbE3A CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE3A Mb1999, yrbE3A, len: 134 aa. Similar to 5' end of Rv1964, len: 265 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 102 aa overlap). yrbE3A,hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa), O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa),Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from Escherichia coli (260 aa), FASTA scores: opt: 893, E(): 0,(51.4% identity in 253 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of yrbE3A, the entire mce3 operon and the following genes up to Mb2000 compared to Mycobacterium tuberculosis strain H37Rv. Q7TZ69 No NC_002945.3 Mycobrowser_v2 CDS 2199824 2200672 . + 0 Mb2000 conserved protein Mb2000, -, len: 282 aa. Equivalent to Rv1978, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151, E(): 0.0072, (30.6% identity in 121 aa overlap). Q7TZ68 No conserved hypotheticals Rv1978 NC_002945.3 Mycobrowser_v2 CDS 2200635 2202080 . - 0 Mb2001c POSSIBLE CONSERVED PERMEASE Mb2001c, -, len: 481 aa. Equivalent to Rv1979c,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 480 aa overlap). Possible permease, APC family possibly involved in transport of amino acid,showing some similarity to other permeases. Also similar to MTCY39.19 from Mycobacterium tuberculosis (28.2% identity in 277 aa overlap). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. X2BJP4,Q7TZ67 No cell wall and cell processes Rv1979c NC_002945.3 Mycobrowser_v2 CDS 2202259 2202945 . - 0 Mb2002c mpt64 IMMUNOGENIC PROTEIN MPT64 (ANTIGEN MPT64/MPB64) Mb2002c, -, len: 228 aa. Equivalent to Rv1980c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). mpt64 (alternate gene name: mpb64), immunogenic protein (alternate gene name: mpb64) (see citations below), identical to MPT64|MPB64 from Mycobacterium bovis (228 aa). Similar to Rv3036c|MTV012.51c from Mycobacterium tuberculosis. Exported protein containing a N-terminal signal sequence: see notes below about proteomics. X2BJ68,P0A5Q5 No cell wall and cell processes Rv1980c NC_002945.3 Mycobrowser_v2 CDS 2203136 2204104 . - 0 Mb2003c nrdF1 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF1 (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) Mb2003c, nrdF1, len: 322 aa. Equivalent to Rv1981c,len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 322 aa overlap). nrdF1,ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1) (see citation below), highly similar to others e.g. RIR4_SALTY|P17424 ribonucleoside-diphosphate reductase (319 aa), FASTA scores: opt: 1402, E(): 0,(66.0% identity in 315 aa overlap); etc. Also similar to Rv3048c|MTV012.63c from Mycobacterium tuberculosis. Contains PS00368 Ribonucleotide reductase small subunit signature. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. COFACTOR: BINDS 2 IRON IONS (BY SIMILARITY). Note that previously known as nrdF. Q7TZ66 No NC_002945.3 Mycobrowser_v2 CDS 2204329 2204748 . - 0 Mb2004c vapc36 possible toxin vapc36. contains pin domain. Mb2004c, -, len: 139 aa. Equivalent to Rv1982c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein. BELONGS TO THE UPF0110 FAMILY. Similar to Rv0624|Z92772|MTY20H10.05 from Mycobacterium tuberculosis (131 aa), FASTA scores: opt: 288, E(): 4.1e-14, (40.2% identity in 127 aa overlap); also similar to Rv0624, Rv2759c, and Rv0609 X2BJH4,P0A653 No virulence, detoxification, adaptation Rv1982c NC_002945.3 Mycobrowser_v2 CDS 2204757 2205017 . - 0 Mb2004A vapB36 Possible antitoxin VapB36 Mb2004A, len: 86 aa. Equivalent to Rv1982A len: 86 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 86 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB36,antitoxin,part of toxin-antitoxin (TA) operon with Rv1982c, see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv0623, Rv2760c, Rv0608 X2BJT5 No virulence, detoxification, adaptation Rv1982A NC_002945.3 Mycobrowser_v2 CDS 2205160 2206836 . + 0 Mb2005 PE_PGRS35 pe-pgrs family protein pe_pgrs35 Mb2005, PE_PGRS35, len: 558 aa. Equivalent to Rv1983, len: 558 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 558 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site. Q7TZ65 No NC_002945.3 Mycobrowser_v2 CDS 2206824 2207477 . - 0 Mb2006c cfp21 PROBABLE CUTINASE PRECURSOR CFP21 Mb2006c, cfp21, len: 217 aa. Equivalent to Rv1984c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). cfp21, probable cutinase precursor with N-terminal signal sequence (EC 3.1.1.-), similar to P41744|CUTI_ALTBR cutinase precursor from Alternaria brassicicola (209 aa), FASTA scores: opt: 283, E(): 2.2e-11, (32.6% identity in 193 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Rv3452, Rv3451, Rv2301, Rv1758, Rv3724. BELONGS TO THE CUTINASE FAMILY. X2BJ73,P63880 No NC_002945.3 Mycobrowser_v2 CDS 2213559 2213807 . - 0 Mb2014A mazE6 Antitoxin MazE6 Mb2014A, len: 82 aa. Equivalent to Rv1991A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). MazE6, antitoxin, part of toxin-antitoxin (TA) operon with Rv1991c. Similar to ChpI of L. interrogans, FASTA scores: opt: 134, E(): 0.024,29.762% identity (65.476% similar) in 84 aa overlap. Note that Pandey and Gerdes, 2005 predicts a different N-terminus, adding 10 amino acids. X2BJQ6,P0CL58 No virulence, detoxification, adaptation Rv1991A NC_002945.3 Mycobrowser_v2 CDS 2212797 2213132 . - 0 Mb2013c POSSIBLE DEHYDROGENASE (FRAGMENT) Mb2013c, -, len: 111 aa. Equivalent to Rv1990A,len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Possible dehydrogenase (fragment) (EC 1.-.-.-), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% identity in 78 aa overlap), but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa),FASTA scores: opt: 142, E(): 0.018, (54.15% identity in 48 aa overlap). Q7TVB7 No intermediary metabolism and respiration Rv1990A NC_002945.3 Mycobrowser_v2 CDS 2207907 2208818 . - 0 Mb2007c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LYSR-FAMILY) Mb2007c, -, len: 303 aa. Equivalent to Rv1985c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Probable transcriptional regulatory protein, LysR family member. Similar to many regulatory proteins, especially ICIA_ECOLI|P24194 chromosome initiation inhibitor from Escherichia coli (297 aa), FASTA scores: opt: 520, E(): 1.1e-28, (35.8% identity in 285 aa overlap); and P94632|LYSG_CORGL LYSINE EXPORT REGULATOR PROTEIN (290 aa), FASTA scores: opt: 705, E(): 0, (42.7% identity in 288 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Also contains helix-turn-helix motif at aa 22-43,(+5.52 SD). BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. X2BJS2,P67666 No regulatory proteins Rv1985c NC_002945.3 Mycobrowser_v2 CDS 2208927 2209526 . + 0 Mb2008 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2008, -, len: 199 aa. Equivalent to Rv1986, len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to P11667|YGGA_ECOLI hypothetical 23.2 kd protein in sbm-fba intergenic region (211 aa), FASTA scores: opt: 379, E(): 1.5e-19, (37.3% identity in 185 aa overlap); and Q11154|Rv0488 HYPOTHETICAL 20.9 KD PROTEIN from Mycobacterium tuberculosis (201 aa), FASTA scores: opt: 784, E(): 0,(63.4% identity in 186 aa overlap). BELONGS TO THE LYSE/YGGA FAMILY. X2BJH6,P64904 No cell wall and cell processes Rv1986 NC_002945.3 Mycobrowser_v2 CDS 2210596 2211135 . + 0 Mb2010 erm(37) probable 23s rrna methyltransferase erm(37) Mb2010, -, len: 179 aa. Equivalent to Rv1988, len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable methyltransferase (EC 2.1.1.-), similar to ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 aa), FASTA scores: opt: 259, E(): 2e-11, (35.1% identity in 171 aa overlap); contains PS00092 N-6 Adenine-specific DNA methylases signature. Also similar to Mycobacterium tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase. Q7TZ64 No intermediary metabolism and respiration Rv1988 NC_002945.3 Mycobrowser_v2 CDS 2211655 2212215 . - 0 Mb2011c HYPOTHETICAL PROTEIN Mb2011c, -, len: 186 aa. Equivalent to Rv1989c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Hypothetical unknown protein. X2BJ76,P64908 No conserved hypotheticals Rv1989c NC_002945.3 Mycobrowser_v2 CDS 2212212 2212553 . - 0 Mb2012c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb2012c, -, len: 113 aa. Equivalent to Rv1990c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Probable transcriptional regulatory protein, similar to Mycobacterium tuberculosis Rv3188|AL021646|MTV014.32 (115 aa), FASTA scores: opt: 184, E(): 8.2e-07, (28.4% identity in 109 aa overlap). Contains probable helix-turn-helix motif at aa 20-44 (+4.22 SD). X2BJS5 No regulatory proteins Rv1990c NC_002945.3 Mycobrowser_v2 CDS 2217920 2218873 . + 0 Mb2019 universal stress protein family protein Mb2019, -, len: 317 aa. Identical to Rv1996, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 317 aa overlap). Conserved hypothetical protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scores: opt: 775, E(): 0, (50.3% identity in 316 aa overlap); Rv2026c (294 aa) (47.9% identity in 311 aa overlap); and Rv2623,etc. Also similar to SCJ1.30c|AL109962 hypothetical protein from Streptomyces coelicolor (328 aa). X2BJQ9,P0A5F8 No NC_002945.3 Mycobrowser_v2 CDS 2219075 2221792 . + 0 Mb2020 ctpF PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE A CTPF Mb2020, ctpF, len: 905 aa. Equivalent to Rv1997,len: 905 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 905 aa overlap). Probable ctpF, metal cation-transporting P-type ATPase F (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. NP_250120.1|NC_002516 probable cation-transporting P-type ATPase from Pseudomonas aeruginosa (902 aa); NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (905 aa); NP_404093.1|NC_003143 putative cation-transporting P-type ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 2392, E(): 0, (46.5% identity in 852 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Was frame-shifted in original cosmid sequence. X2BJ82,P63688 No cell wall and cell processes Rv1997 NC_002945.3 Mycobrowser_v2 CDS 2221861 2222637 . - 0 Mb2021c conserved protein Mb2021c, -, len: 258 aa. Equivalent to Rv1998c,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 258 aa overlap). Conserved hypothetical protein, showing some similarity with other hypothetical proteins e.g. U82823|SEU82823.03 Saccharopolyspora erythraea (266 aa), FASTA results: opt: 654, E(): 0,(43.8% identity in 249 aa overlap); and AL034446|SC1A9.07 Streptomyces coelicolor (251 aa), FASTA scores: opt: 592,E(): 1.5e-31, (43.4% identity in 251 aa overlap). Q7TZ63 No conserved hypotheticals Rv1998c NC_002945.3 Mycobrowser_v2 CDS 2298000 2298266 . - 0 Mb2081c rpsR2 30s ribosomal protein s18 rpsr2 Mb2081c, rpsR2, len: 88 aa. Equivalent to Rv2055c,len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Probable rpsR2,ribosomal protein S18, similar to others e.g. RR18_ODOSI|P49505 chloroplast 30S ribosomal protein S18 (72 aa), FASTA scores: opt: 209, E(): 4.7e-09, (51.6% identity in 64 aa overlap); etc. Also similar to rpsR|Rv0055|MTCY21D4.18 from Mycobacterium tuberculosis (50.0% identity in 84 aa overlap). X2BJZ9,P66466 No NC_002945.3 Mycobrowser_v2 CDS 2222732 2224054 . - 0 Mb2022c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2022c, -, len: 440 aa. Equivalent to Rv1999c,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable conserved integral membrane protein, possibly transporter of cationic amino acid, similar to many transporters,especially amino acid transporters, e.g. CAC08265.1|AL392146 putative amino acid transporter from Streptomyces coelicolor (414 aa); P39277|YJEH_ECOLI hypothetical 44.8 kd protein from Escherichia coli (418 aa), FASTA scores, opt: 343, E(): 6.6e-15, (27.2% identity in 408 aa overlap); etc. Also similar to Rv1979c from Mycobacterium tuberculosis, FASTA score: (28.2% identity in 277 aa overlap); Rv2127, Rv0346c, Rv0522, etc. SEEMS TO BELONG TO THE APC FAMILY. X2BJI4,P63350 No cell wall and cell processes Rv1999c NC_002945.3 Mycobrowser_v2 CDS 2224125 2225738 . + 0 Mb2023 unknown protein Mb2023, -, len: 537 aa. Equivalent to Rv2000, len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 537 aa overlap). Hypothetical unknown protein. X2BJU5 No conserved hypotheticals Rv2000 NC_002945.3 Mycobrowser_v2 CDS 2226576 2227358 . + 0 Mb2025 fabG3 POSSIBLE 20-BETA-HYDROXYSTEROID DEHYDROGENASE FABG3 (Cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) Mb2025, fabG3, len: 260 aa. Equivalent to Rv2002,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Possible fabG3,20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53),similar to e.g. 2BHD_STREX|P19992 20-beta-hydroxysteroid dehydrogenase (255 aa), FASTA scores: opt: 718, E(): 2e-38, (49.8% identity in 243 aa overlap), and many mycobacterial proteins. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. X2BJ87,P69166 No NC_002945.3 Mycobrowser_v2 CDS 2228394 2229890 . - 0 Mb2027c conserved protein Mb2027c, -, len: 498 aa. Equivalent to Rv2004c,len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 498 aa overlap). Conserved hypothetical protein similar to several e.g. >pir||T36945 hypothetical protein SCJ1.12 (508 aa) - Streptomyces coelicolor >gi|5748625|emb|CAB53130.1| (AL109962). Smith-Waterman score: 7e-94, Identities = 199/468 (42%). Contains PS00017 ATP/GTP-binding site motif A. X2BJI8,P0A5G0 No conserved hypotheticals Rv2004c NC_002945.3 Mycobrowser_v2 CDS 2229912 2230799 . - 0 Mb2028c universal stress protein family protein Mb2028c, -, len: 295 aa. Equivalent to Rv2005c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Conserved hypothetical protein, similar to MTCY39.23c, (50.3% identity in 316 aa overlap), C-terminus shows some similarity with YXIE_BACSU P42297 hypothetical 15.9 kd protein in bglh- (148 aa), FASTA scores, opt: 124, E(): 0.038, (28.5% identity in 144 aa overlap), also similar to Rv2623 (294 aa), (52.7% identity in 296 aa overlap) and other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1996, Rv2624c, Rv2028c, Rv3134c, Rv1636. Some,possibly all, of these belong to universal stress protein family. X2BJU8,P64922 No virulence, detoxification, adaptation Rv2005c NC_002945.3 Mycobrowser_v2 CDS 2230918 2234901 . + 0 Mb2029 otsB1 PROBABLE TREHALOSE-6-PHOSPHATE PHOSPHATASE OTSB1 (TREHALOSE-PHOSPHATASE) (TPP) Mb2029, otsB1, len: 1327 aa. Equivalent to Rv2006,len: 1327 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1327 aa overlap). Probable otsB1, trehalose-6-phosphate phosphatase (EC 3.1.3.12) (see citations below); strong similarity in central domain to OTSB_ECOLI P31678 trehalose-phosphatase (266 aa) and M. leprae TREHALOSE-PHOSPHATASE Q49734 (429 aa). Belongs to Glycosyl hydrolases family 65 (http://www.expasy.ch/cgi-bin/lists?glycosid.txt). FASTA scores, sp|Q49734|Q49734 PUTATIVE TREHALOSE-PHOSPHATASE (429 aa) opt: 1283 E(): 0; 51.7% identity in 420 aa overlap opt: 278, E(): 3.6e-11, (29.4% identity in 255 aa overlap). Note that previously known as otsB. Q7TZ61 No NC_002945.3 Mycobrowser_v2 CDS 2245721 2246026 . - 0 Mb2044c transcriptional regulatory protein Mb2044c, -, len: 101 aa. Equivalent to Rv2021c,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Unknown, possible regulatory protein similar to Mycobacterium tuberculosis hypothetical protein Rv3183, MTV014.27 (EMBL; AL021646). FASTA scores; TR:E12487 74 (109 aa) opt: 214 E(): 1.2e-09,43.0% identity in 107 aa overlap. Contains probable helix-turn-helix at aa 45-66 (Score 1472, +4.20 SD) Q7TZ52 No regulatory proteins Rv2021c NC_002945.3 Mycobrowser_v2 CDS 2235533 2236858 . - 0 Mb2031c CONSERVED HYPOTHETICAL PROTEIN Mb2031c, -, len: 441 aa. Equivalent to Rv2008c,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Conserved hypothetical protein. Contains PS00017 ATP/GTP-binding site motif A, PS00501 Signal peptidases I serine active site. Also contains helix-turn-helix motif at aa 258-279. Similar to several conserved hypothetical proteins e.g. NP_085874.1|14028123|dbj|BAB54715.1 hypothetical protein from Mesorhizobium loti (435 aa). Smith-Waterman score: 1e-74, Identities = 158/359 (44%) X2BJU6,P64924 No conserved hypotheticals Rv2008c NC_002945.3 Mycobrowser_v2 CDS 2236946 2237188 . + 0 Mb2032 vapb15 antitoxin vapb15 Mb2032, -, len: 80 aa. Equivalent to Rv2009, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 80 aa overlap). Conserved hypothetical protein, very similar to Rv1560|MTCY48.05c (54.4% identity in 68 aa overlap). Q7TZ60 No virulence, detoxification, adaptation Rv2009 NC_002945.3 Mycobrowser_v2 CDS 2237189 2237587 . + 0 Mb2033 vapc15 toxin vapc15 Mb2033, -, len: 132 aa. Equivalent to Rv2010, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Conserved hypothetical protein, similar to Rv1561|MTCY48.04c, (38.1% identity in 126 aa overlap) X2BJV0,P64926 No virulence, detoxification, adaptation Rv2010 NC_002945.3 Mycobrowser_v2 CDS 2237770 2238201 . - 0 Mb2034c conserved hypothetical protein, probable transcription repressor. Mb2034c, -, len: 143 aa. Equivalent to Rv2011c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein, some similarity to putative regulatory proteins e.g. putative marR-family regulatory protein from Streptomyces coelicolor A3(2) (157 aa),emb|CAB63189.1| (AL133469) 34% identity in 110 aa overlap. Low similarity to PETP_RHOCA P31078 petp protein. Rhodobacter capsulatus (166 aa), FASTA scores, opt: 101,E(): 0 .36, (31.8% identity in 88 aa overlap) X2BJS0 No regulatory proteins Rv2011c NC_002945.3 Mycobrowser_v2 CDS 2238242 2238736 . + 0 Mb2035 CONSERVED HYPOTHETICAL PROTEIN Mb2035, -, len: 164 aa. Equivalent to Rv2012, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Conserved hypothetical protein, similar to AAK04358.1|AE006263_5 hypothetical protein from Lactococcus lactis (137 aa),(48% identity in 129 aa overlap). X2BJ94 No conserved hypotheticals Rv2012 NC_002945.3 Mycobrowser_v2 CDS 2239440 2240060 . + 0 Mb2036 transposase Mb2036, -, len: 206 aa. Similar to Rv2013, len: 159 aa, from Mycobacterium tuberculosis strain H37Rv. Possible transposase: shows similarity to N-terminal part of transposase and insertion element hypothetical proteins eg sp|Q53198|Y4UE_RHISN PUTATIVE TRANSPOSASE Y4UE (359 aa) opt: 383, E(): 1.3e-18; 35.1% identity in 225 aa overlap; sp|P 14707|YM3_STRCO MINI-CIRCLE HYPOTHETICAL 45.7 KD P (414 aa) opt: 302, E(): 4.2e-13; 33.3% identity in 207 aa overlap; and YI90_MYCPA P14322 insertion element is900 hypothetical protein (399 aa), FASTA scores, opt: 146,E(): 0.0021, (26.9% identity in 145 aa overlap). Length changed since first submission (no clear start apparent). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) at the 5' start of Mb2036,leads to a longer product with a different NH2 part compared toits homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa). Q7TZ59 No NC_002945.3 Mycobrowser_v2 CDS 2322760 2323704 . + 0 Mb2109 CONSERVED HYPOTHETICAL PROTEIN Mb2109, -, len: 314 aa. Equivalent to Rv2083, len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 314 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv3898c (110 aa) and Rv3897c (210 aa) Q7TZ23 No conserved hypotheticals Rv2083 NC_002945.3 Mycobrowser_v2 CDS 2240014 2240604 . + 0 Mb2037 transposase Mb2037, -, len: 196 aa. Equivalent to Rv2014, len: 196 aa, from Mycobacterium tuberculosis strain H37Rv, (). Possible transposase, similar to insertion elements e.g. sp|P14707|YM3_STRCO MINI-CIRCLE HYPOT HETICAL 45.7 KD P (414 aa) opt: 249 z-score: 307.0 E(): 1.4e-09; 33.1% identity in 169 aa overlap; and YI90_MYCPA P14322 insertion element is900 hypothetical protein (399 a a),FASTA scores, opt: 242, z-score: 299.9, E(): 3.7e-10, (3 2.5% identity in 163 aa overlap); possibly made by frameshifting with respect to upstream ORF. Length changed since first submission. Q7TZ58 No insertion seqs and phages Rv2014 NC_002945.3 Mycobrowser_v2 CDS 2240732 2241988 . - 0 Mb2038c CONSERVED HYPOTHETICAL PROTEIN Mb2038c, -, len: 418 aa. Equivalent to Rv2015c,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 418 aa overlap). Conserved hypothetical protein. Nearly identical to Mycobacterium tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting next to ISB9, and ending in IS6110. Different N-terminus chosen and C-terminus differs as that of Rv1765c has been truncated by IS6110. Does NOT show similarities with transposases. BLAST hits with non-IS part of MTU78639. FASTA scores: Z95890|MTCY28_31 (378 aa) opt: 2417, E(): 0,(97.8% identity in 364 aa overlap). Q7TZ57 No conserved hypotheticals Rv2015c NC_002945.3 Mycobrowser_v2 CDS 2242342 2242917 . + 0 Mb2039 HYPOTHETICAL PROTEIN Mb2039, -, len: 191 aa. Equivalent to Rv2016, len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 191 aa overlap). Hypothetical protein. Q7TZ56 No conserved hypotheticals Rv2016 NC_002945.3 Mycobrowser_v2 CDS 2316945 2317259 . + 0 Mb2104 conserved hypothetical protein Mb2104, -, len: 104 aa. Equivalent to Rv2078, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 104 aa overlap). Unknown X2BJE3 No conserved hypotheticals Rv2078 NC_002945.3 Mycobrowser_v2 CDS 2242914 2243954 . + 0 Mb2040 transcriptional regulatory protein Mb2040, -, len: 346 aa. Equivalent to Rv2017, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 346 aa overlap). Hypothetical regulatory protein, shows similarity at N-terminal end to several transcriptional regulators e.g. Bacillus subtilis BSUB0012_44 (108 aa). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature in C-terminal half, may be fortuitous. FASTA scores: Z99115|BSUB0012_44 Bacillus subtilis (108 aa) opt: 154,E(): 0.0012; 35.5% identity in 62 aa overlap. Contains probable helix-turn-helix motif at aa 18-39 (Score 2243,+6.83 SD) Q7VET2 No regulatory proteins Rv2017 NC_002945.3 Mycobrowser_v2 CDS 2244196 2244915 . + 0 Mb2041 conserved protein Mb2041, -, len: 239 aa. Equivalent to Rv2018, len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 239 aa overlap). Conserved hypothetical protein, similar to Rv2308|MTCY339.01c (238 aa). FASTA scores: Z77163|MTCY339_1 Mycobacterium tuberculosis cosmid (238 aa) opt: 142, E(): 0.029; (24.8% identity in 250 aa overlap). Contains probable helix-turn-helix motif at aa 215-236 (Score 1175, +3.19 SD). Q7TZ55 No conserved hypotheticals Rv2018 NC_002945.3 Mycobrowser_v2 CDS 2246035 2246640 . - 0 Mb2045c conserved protein Mb2045c, -, len: 201 aa. Equivalent to Rv2022c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv3182, MTV014.26 (EMBL:AL 021646). FASTA scores; TR:E1248773 (114 aa) opt: 335, E(): 3e-22, 53.8% identity in 106 aa overlap and to hypothetical proteins from Yersinia pestis (115 aa) e.g. emb|CAB53172.1| (AL109969), 41% identity in 108 aa overlap. Q7TZ51 No conserved hypotheticals Rv2022c NC_002945.3 Mycobrowser_v2 CDS 2246665 2247024 . - 0 Mb2046c HYPOTHETICAL PROTEIN Mb2046c, -, len: 119 aa. Equivalent to Rv2023c,len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical protein,alternative upstream start possible. Q7TZ50 No conserved hypotheticals Rv2023c NC_002945.3 Mycobrowser_v2 CDS 2249336 2254156 . - 0 Mb2049c CONSERVED HYPOTHETICAL PROTEIN Mb2049c, RvD1-Rv2024c, len: 1606 aa. Equivalent to Rv2024c and similar to Rv2020c, len: 515 aa and 99 aa,from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 506 aa overlap and 67.0% identity in 97 aa overlap). Rv2024c: Conserved hypothetical protein. Identical to N-terminal part of much larger hypothetical protein, RvD1-Rv2024c' (1606 aa), from Mycobacterium bovis BCG: CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably truncated. Part of RvD1 chromosomal deletion region. Also similar to hypothetical protein from Helicobacter pylori. FASTA scores: AE0005|HPAE000580_2 Helicobacter pylori (607 aa) opt: 64, E(): 0, (36.2% identity in 464 aa overlap). Rv2020c: Conserved hypothetical protein, nearly identical to C-terminal part of hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds to deletion region RvD1 so probably truncated protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa). Q7TZ47 No NC_002945.3 Mycobrowser_v2 CDS 2254664 2255662 . - 0 Mb2050c conserved membrane protein Mb2050c, -, len: 332 aa. Equivalent to Rv2025c,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 332 aa overlap). Possible conserved transmembrane protein, CDF family possibly involved in transport of metal ions, similar to several hypothetical bacterial proteins e. g. Methanobacterium thermoautotrophicum AE000941_1 (298 aa; described as cation efflux system protein) and Archaeoglob us fulgidus AE001111_5 (384 aa). FASTA scores: AE000941_1 M ethanobacterium thermoautotrophicum (298 aa) opt: 452 E(): 3.3e-24; 30.8% identity in 266 aa overlap and AE001111_5 Archaeoglobus fulgidus section 16 (384 aa) opt: 371 E(): 1.7e-18; 27.7% identity in 267 aa overlap. TBparse score is 0.897 Q7TZ46 No cell wall and cell processes Rv2025c NC_002945.3 Mycobrowser_v2 CDS 2255777 2256661 . - 0 Mb2051c universal stress protein family protein Mb2051c, -, len: 294 aa. Equivalent to Rv2026c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Conserved hypothetical protein, very similar to Mycobacterium tuberculosis hypothetical proteins Rv2005c, Rv2623,Rv1996, Rv2624c, Rv2028c, Rv3134c, Rv1636. Some, possibly all, of these belong to universal stress protein family. Q7TZ45 No virulence, detoxification, adaptation Rv2026c NC_002945.3 Mycobrowser_v2 CDS 2256701 2258422 . - 0 Mb2052c dost two component sensor histidine kinase dost Mb2052c, -, len: 573 aa. Equivalent to Rv2027c,len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 573 aa overlap). Membrane protein related to histidine kinase response regulators. Highly similar to Mycobacterium tuberculosis protein Rv3132c,MTCY03A2.2 6. FASTA scores: Z83867|MTCY3A2_26 (578 aa) opt: 2330, E(): 0; 62.5% identity in 560 aa overlap. Q7VET1 No regulatory proteins Rv2027c NC_002945.3 Mycobrowser_v2 CDS 2258483 2259322 . - 0 Mb2053c universal stress protein family protein Mb2053c, -, len: 279 aa. Equivalent to Rv2028c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Conserved hypothetical protein, highly similar to Mycobacterium tuberculosis proteins Rv2005c, Rv2623, Rv1996, Rv2624c,Rv3134c, Rv1636. Some, possibly all, of these belong to universal stress protein family. Rv2624c|MTCY01A10.08 (272 aa) and Rv3134c|MTCY03A2.24 (268 aa). FASTA scores: Z95387|MTCY1A10_8 (272 aa) opt: 563, E(): 2.5e-31, (36.8% identity in 266 aa overlap) and Z83867|MTCY3A2_24 (268 aa) opt: 562, E(): 2.9e-31, (40.7% identity in 273 aa overlap). Q7TZ44 No virulence, detoxification, adaptation Rv2028c NC_002945.3 Mycobrowser_v2 CDS 2259319 2260338 . - 0 Mb2054c pfkB 6-phosphofructokinase pfkb (phosphohexokinase) (phosphofructokinase) Mb2054c, pfkB, len: 339 aa. Equivalent to Rv2029c,len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 339 aa overlap). Probable pfkB,phosphofructokinase (EC 2.7.1.-), similar to others eg P06999|K6P2_ECOLI 6-PHOSPHOFRUCTOKINASE I SOZYME 2 from E. coli (309 aa), FASTA scores: opt: 705, E(): 0; (41.4% identity in 304 aa overlap); and LACC_STRMU phosphotagatosekinase (310 aa); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. Q7TZ43 No NC_002945.3 Mycobrowser_v2 CDS 2260355 2260594 . - 0 Mb2055c CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb2055c, -, len: 79 aa. Equivalent to 3' end of Rv2030c, len: 681 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 79 aa overlap). Conserved hypothetical protein that corresponds to products of two adjacent ORF's described previously MSGTUBDWN_4 (390 aa) and MSGTUBDWN_1 (385 aa). Also similar to C-terminal two-thirds of Mycobacterium tuberculosis protein Rv2143 (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and Mycobacterium leprae protein U650s MLU15184_16 (258 aa). FASTA scores: M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; 97.7% identity in 385 aa overlap and M93129|MSGTUBDWN_1 (385 aa) opt: 1983 E(): 0; 99.0% identity in 309 aa overlap. Z95388| MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 % identity in 226 aa overlap. U15184|MLU15184_16 (258 aa) opt: 549 E(): 9.8e-29; 43.8% identity in 219 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c. Q7TZ42 No NC_002945.3 Mycobrowser_v2 CDS 2291734 2292069 . + 0 Mb2076 conserved protein Mb2076, -, len: 111 aa. Equivalent to Rv2050, len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium leprae, MLCB2052.03c (113 aa), and Streptomyces coelicolor A3(2), SC6D7.18c (124 aa). FASTA scores: Z98604|MLCB2052_3 Mycobacterium leprae cosmid B2052 (113 aa) opt: 737, E(): 0, (97.3% identity in 111 aa overlap) and (55% identity in 85 aa overlap) with emb|CAB61670.1|AL133213 hypothetical protein SC6D7.18c. TBparse score is 0.884 Q7TZ33 No conserved hypotheticals Rv2050 NC_002945.3 Mycobrowser_v2 CDS 2273598 2275133 . - 0 Mb2071c lipT carboxylesterase lipt Mb2071c, lipT, len: 511 aa. Equivalent to Rv2045c,len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable lipT,carboxylesterase similar to many e.g. O08472 (489 aa) and P37967|PNBA_ BACSU (489 aa). PARA-NITROBENZYL ESTERASE (EC 3.1.1.-). Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site. FASTA scores: sptr|O08472|O08472 INTRACELLULAR ESTERASE B (489 aa) opt: 849, E(): 0, (36.2% identity in 489 aa overlap) and sp|P37967|PNBA_BACSU PARA-NITROBENZYL ESTERASE (489 aa) opt: 838, E(): 0,(36.0% identity in 489 aa overlap). TBparse score is 0 .918 Q7VES4 No NC_002945.3 Mycobrowser_v2 CDS 2260579 2262399 . - 0 Mb2056c CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb2056c, -, len: 606 aa. Equivalent to 5' end of Rv2030c, len: 681 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 587 aa overlap). Conserved hypothetical protein that corresponds to products of two adjacent ORF's described previously MSGTUBDWN_4 (390 aa) and MSGTUBDWN_1 (385 aa). Also similar to C-terminal two-thirds of Mycobacterium tuberculosis protein Rv2143 (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and Mycobacterium leprae protein U650s MLU15184_16 (258 aa). FASTA scores: M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; 97.7% identity in 385 aa overlap and M93129|MSGTUBDWN_1 (385 aa) opt: 1983 E(): 0; 99.0% identity in 309 aa overlap. Z95388| MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 % identity in 226 aa overlap. U15184|MLU15184_16 (258 aa) opt: 549 E(): 9.8e-29; 43.8% identity in 219 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c. Q7TZ41 No NC_002945.3 Mycobrowser_v2 CDS 2298738 2298974 . - 0 Mb2084c rpmB2 50s ribosomal protein l28 rpmb2 Mb2084c, rpmB2, len: 78 aa. Equivalent to Rv2058c,len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Probable rpmB2,ribosomal protein L28, very similar to rL28 of M. tuberculosis. FASTA results: RL28_MYCTU Q10879 50S ribosomal protein L28. mycobacter (94 aa) opt: 338; E(): 9.8e-19; 64.9% identity in 77 aa overlap. Also similar to rpmB (Rv0105c) of Mycobacterium tuberculosis. X2BJX7,P66149 No NC_002945.3 Mycobrowser_v2 CDS 2262411 2262845 . - 0 Mb2057c hspX heat shock protein hspx (alpha-crystallin homolog) (14 kda antigen) (hsp16.3) Mb2057c, hspX, len: 144 aa. Equivalent to Rv2031c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). hspX, heat shock protein localized in the inner membrane (see citations below). Identical to P30223|14KD_MYCTU 14 KD ANTIGEN (16 kDa ANTIGEN) (HSP 16.3) of Mycobacterium tuberculosis (143 aa), FASTA scores: opt: 933, E(): 0, (100.0% identity in 143 aa overlap). BELONGS TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY. Also known as alpha-crystallin and gene as acr (see some citations below). TBparse score is 0.897. X2BJK6,P0A5B8 No NC_002945.3 Mycobrowser_v2 CDS 2266660 2267634 . - 0 Mb2063c conserved transmembrane protein Mb2063c, -, len: 324 aa. Equivalent to Rv2037c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 324 aa overlap). Possible conserved transmembrane protein, similar to hypothetical proteins from Mycobacterium leprae MLCB2052.31 (329 aa) and Bacillus subtilis P54513|YQHO_BACSU (291 aa). FASTA scores: Z98604|MLCB2052_1 6 Mycobacterium leprae cosmid B205 (329 aa) opt: 1764, E(): 0; 80.5% identity in 323 aa overlap and sp|P54513|YQHO_BACSU HYPOTHETICAL 32.9 KD PROTEIN IN G (291 aa ) opt: 328, E(): 8.8e-14; 36.6% identity in 306 aa overlap. TBparse score is 0.919 Q7TZ37 No cell wall and cell processes Rv2037c NC_002945.3 Mycobrowser_v2 CDS 2263042 2264037 . + 0 Mb2058 acg conserved protein acg Mb2058, -, len: 331 aa. Equivalent to Rv2032, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 331 aa overlap). acg (for acr-coregulated gene), conserved hypothetical protein possibly member of a superfamily of classical nitroreductases (see first citation below), similar to hypothetical mycobacterial proteins Rv3127|MTCY164.37 (344 aa) and Rv3131|MTCY03A2.27c (332 aa). FASTA scores: Z95150|MTCY164_38 Mycobacterium tuberculosis cosmid (344 aa) opt: 1208, E(): 0, (56.4% identity in 321 aa overlap); Z83867| MTCY3A2_27 Mycobacterium tuberculosis cosmid (332 aa) opt: 568, E(): 8.6e-30, (36.8% identity in 321 aa overlap). Similar to proteins SCJ1.11 (330 aa; AL109962) and SCJ12.27c (335 aa; AL109989) in Streptomyces coelicolor. Q7VET0 No conserved hypotheticals Rv2032 NC_002945.3 Mycobrowser_v2 CDS 2264153 2264995 . - 0 Mb2059c CONSERVED HYPOTHETICAL PROTEIN Mb2059c, -, len: 280 aa. Equivalent to Rv2033c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, similar to hypothetical protein SCC77.24 (274 aa) from Streptomyces coelicolor A3(2) CAB66235.1|AL13650) (50% identity in 261 aa overlap). Q7TZ40 No conserved hypotheticals Rv2033c NC_002945.3 Mycobrowser_v2 CDS 2265207 2265530 . + 0 Mb2060 arsr repressor protein Mb2060, -, len: 107 aa. Equivalent to Rv2034, len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 107 aa overlap). Probable repressor protein similar to several belonging to the ARSR FAMILY e.g. Q53040 (112 aa). FASTA scores: sptr|Q53040|Q53040 NITRILE HYDRATASE REGULATAR 2 (112 aa) opt: 167, E( ): 6.7e-06; 44.7% identity in 76 aa overlap. TBparse score is 0.905. Contains probable helix-turn-helix at aa 32-53 (S core 1350, +3.78 SD) Q7VES9 No regulatory proteins Rv2034 NC_002945.3 Mycobrowser_v2 CDS 2265527 2266015 . + 0 Mb2061 CONSERVED HYPOTHETICAL PROTEIN Mb2061, -, len: 162 aa. Equivalent to Rv2035, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical protein (156 aa) from Sinorhizobium meliloti CAC46569.1|AL591789 (34% identity in 146 aa overlap). Q7TZ39 No conserved hypotheticals Rv2035 NC_002945.3 Mycobrowser_v2 CDS 2266012 2266653 . + 0 Mb2062 CONSERVED HYPOTHETICAL PROTEIN Mb2062, -, len: 213 aa. Equivalent to Rv2036, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 213 aa overlap). Conserved hypothetical protein; slight similarity to Streptomyces lincolnensis protein involved in lincomycin production Q54375 (238 aa). FASTA scores: sptr|Q54375|Q54375 (78-11) LINCOMYCIN PRODUCTION GENES (238 aa) opt: 119, E(): 0.97; 31.3% identity in 99 aa overlap. TBparse score is 0.934 Q7TZ38 No conserved hypotheticals Rv2036 NC_002945.3 Mycobrowser_v2 CDS 2466141 2466563 . - 0 Mb2243c probable conserved membrane protein Mb2243c, -, len: 140 aa. Equivalent to Rv2219A,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable membrane protein, similar to SC3H12.05c|AL355740_5 possible integral membrane protein from Streptomyces coelicolor (155 aa), FASTA scores: opt: 327, E(): 7.5e-14, (46.6% identity in 133 aa overlap), also linked to glnA. Q7TYX1 No cell wall and cell processes Rv2219A NC_002945.3 Mycobrowser_v2 CDS 2267636 2268709 . - 0 Mb2064c Probable sugar-transport ATP-binding protein ABC transporter Mb2064c, -, len: 357 aa. Equivalent to Rv2038c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). Probable sugar-transport ATP-binding protein ABC transporter (see citation below), equivalent to MLCB2052.30|Z98604|MLCB2052_15 from Mycobacterium leprae (356 aa), FASTA scores: opt: 1866, E(): 0, (79.7% identity in 355 aa overlap). Also similar to multiple sugar import proteins e.g. Y08921|SRMSIK_1 msiK protein from Streptomyces reticuli (377 aa), FASTA scores: opt: 1336,E(): 0, (62.6% identity in 377 aa overlap); etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Rv2832c, Rv1238, Rv2397c, Rv3758c. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7VES8 No cell wall and cell processes Rv2038c NC_002945.3 Mycobrowser_v2 CDS 2268712 2269554 . - 0 Mb2065c Probable sugar-transport integral membrane protein ABC transporter Mb2065c, -, len: 280 aa. Equivalent to Rv2039c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 280 aa overlap). Probable sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to MLCB2052.29|Z98604|MLCB2052_14 from Mycobacterium leprae (283 aa), FASTA scores: opt: 1593, E(): 0, (79.2% identity in 283 aa overlap). Also similar to maltose and lactose transport proteins e.g. X66092|CPMALGHOM_1 from C. perfringens (275 aa), FASTA scores: opt: 695, E(): 0,(41.2% identity in 228 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Also contains possible helix-turn-helix motif at aa 171-192, although this is probably fortuitous. Q7VES7 No cell wall and cell processes Rv2039c NC_002945.3 Mycobrowser_v2 CDS 2269541 2270443 . - 0 Mb2066c Probable sugar-transport integral membrane protein ABC transporter Mb2066c, -, len: 300 aa. Equivalent to Rv2040c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to MLCB2052.28|Z98604|MLCB2052_13 from Mycobacterium leprae (319 aa), FASTA scores: opt: 1606, E(): 0, (81.6% identity in 293 aa overlap). Also similar to many diverse sugar transport proteins. Q7VES6 No cell wall and cell processes Rv2040c NC_002945.3 Mycobrowser_v2 CDS 2297038 2297751 . + 0 Mb2080 conserved protein Mb2080, -, len: 237 aa. Equivalent to Rv2054, len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Conserved hypothetical protein, some similarity to various carboxymethylenebutenolidases e.g. sp|O67988|CLCD_RHOOP CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (DLH) >gi|2935034|gb|AAC38252.1| (AF003948) dienelactone hydrolase [Rhodococcus opacus] Smith-Waterman scores: Length = 252, Expect = 4e-08 Identities = 62/217 (28%). Also similar to Rv2765. Q7TZ31 No conserved hypotheticals Rv2054 NC_002945.3 Mycobrowser_v2 CDS 2270440 2271759 . - 0 Mb2067c Probable sugar-binding lipoprotein Mb2067c, -, len: 439 aa. Equivalent to Rv2041c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Probable sugar-binding lipoprotein component of sugar transport system,equivalent to Z98604|MLCB2052_1|MLCB2052.27 from Mycobacterium leprae (445 aa), FASTA scores: opt: 2324,E(): 0, (77.4% identity in 446 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7VES5 No cell wall and cell processes Rv2041c NC_002945.3 Mycobrowser_v2 CDS 2271797 2272594 . - 0 Mb2068c conserved protein Mb2068c, -, len: 265 aa. Equivalent to Rv2042c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Conserved hypothetical protein,similar in N-terminal part to hypothetical proteins MLCB2052.24 (95 aa) and Rv0760c|MTCY369.05 (139 aa). FASTA scores: Z98604|MLCB2052_9 Mycobacterium leprae cosmid B2052 (95 aa) opt: 269, E(): 2.9e-12, (55.4% identity in 92 aa overlap) and Z80226|MTCY369_5 Mycobacterium tuberculosis cosmid (139 aa) opt: 150, E(): 0.001, (28.7% identity in 136 aa overlap). Q7TZ36 No conserved hypotheticals Rv2042c NC_002945.3 Mycobrowser_v2 CDS 2272594 2273154 . - 0 Mb2069c pncA pyrazinamidase/nicotinamidase pnca (pzase) Mb2069c, pncA, len: 186 aa. Equivalent to Rv2043c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 186 aa overlap). pncA,pyrazinamidase/nicotinamidase (EC 3.5.1.-) (see citations below). Identical to PYRAZINAMIDASE/NICOTINAMIDASE involved in susceptibility or resistance to antituberculous drug pyrazinamide. FASTA scores: sptr|Q50575|Q50575 PYRAZINAMIDASE/NICOTINAMIDASE. (186 aa) opt: 1236, E(): 0; 100.0% identity in 186 aa overlap. I3NIF8 No NC_002945.3 Mycobrowser_v2 CDS 2273195 2273512 . - 0 Mb2070c CONSERVED HYPOTHETICAL PROTEIN Mb2070c, -, len: 105 aa. Equivalent to Rv2044c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical protein PA3386 (121 aa) from Pseudomonas aeruginosa |E83221 conserved hypothetical protein PA3386 [imported] -Pseudomonas aeruginosa (strain PAO1) 9949522|gb|AAG06774.1|AE004760_2 (AE004760). (46% identity in 92 aa overlap). Q7TZ35 No conserved hypotheticals Rv2044c NC_002945.3 Mycobrowser_v2 CDS 2275875 2278439 . - 0 Mb2073c CONSERVED HYPOTHETICAL PROTEIN Mb2073c, -, len: 854 aa. Equivalent to Rv2047c,len: 854 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 854 aa overlap). Conserved hypothetical protein, similar to hypothetical protein from Mycobacterium tuberculosis Rv1868|MTCY359.05c (699 aa) and three possible pseudogene fragments from Mycobacterium leprae MLCB2052.16 (251 aa), MLCB2052.17 (120 aa),MLCB2052.18 (257 aa). FASTA scores: gp|Z98604|MLCB2052_7 (257 aa) opt: 1248, E(): 0, (78.6% identity in 248 aa overlap); and Z98604|MLCB2052_5 (251 aa) opt: 674, E(): 0,(50.0% identity in 250 aa overlap); and Z98604|MLCB2052_6 (120 aa) opt: 608 E() : 3.6e-30, (84.0% identity in 106 aa overlap); and Rv1868 Z83859|MTCY359_5 (699 aa) opt: 521 E(): 3e-24; (33.0% identity in 730 aa overlap). X2BJW9,P65685 No conserved hypotheticals Rv2047c NC_002945.3 Mycobrowser_v2 CDS 2278444 2290899 . - 0 Mb2074c pks12 polyketide synthase pks12 Mb2074c, pks12, len: 4151 aa. Equivalent to Rv2048c, len: 4151 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 4151 aa overlap). Probable pks12, polyketide synthase similar to many polyketide synthases e.g. the second and third modules of polyketide synthase from S. erythraea (3567 aa), many other Streptomyces enzymes and putative Mycobacterium tuberculosis polyketide synthases, e.g. Z85982|MTCY06H11.26 (2126 aa), FASTA scores: opt: 6668,E(): 0 (61.2% identity in 2058 aa overlap); and Q03132|ERY2_SACER ERYTHRONOLIDE SYNTHASE, MODULES 3 from S. erythraea (3567 aa), FASTA scores: opt: 5309, E(): 0,(40.5% identity in 4141 aa overlap). Contains 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 Beta-ketoacyl synthases active site, and PS00343 Gram-positive cocci surface proteins 'anchor ing' hexapeptide. Q7VES2 No lipid metabolism Rv2048c NC_002945.3 Mycobrowser_v2 CDS 2291206 2291430 . - 0 Mb2075c conserved hypothetical protein Mb2075c, -, len: 74 aa. Equivalent to Rv2049c, len: 74 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 74 aa overlap). Hypothetical protein. Q7TZ34 No conserved hypotheticals Rv2049c NC_002945.3 Mycobrowser_v2 CDS 2294826 2296430 . - 0 Mb2078c conserved protein Mb2078c, -, len: 534 aa. Equivalent to Rv2052c,len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 534 aa overlap). Conserved hypothetical protein, very similar to hypothetical protein SC6D7.15 (536 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores >emb|CAB61667.1| (AL133213) hypothetical protein SC6D7.15 [Streptomyces coelicolor A3(2)] Expect = e-113 Identities = 247/533 (46%) Q7TZ32 No conserved hypotheticals Rv2052c NC_002945.3 Mycobrowser_v2 CDS 2296435 2296962 . - 0 Mb2079c fxsa probable transmembrane protein fxsa Mb2079c, -, len: 175 aa. Equivalent to Rv2053c,len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Probable transmembrane protein Q7VES0 No cell wall and cell processes Rv2053c NC_002945.3 Mycobrowser_v2 CDS 2324512 2324844 . + 0 Mb2111 HYPOTHETICAL PROTEIN Mb2111, -, len: 110 aa. Similar to 3' end of Rv2084, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, (97.0% identity in 100 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis stain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts,Mb2110 and Mb2111. No NC_002945.3 Mycobrowser_v2 CDS 2346368 2346622 . - 0 Mb2130c vapb37 possible antitoxin vapb37 Mb2130c, -, len: 84 aa. Equivalent to Rv2104c, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Conserved hypothetical protein, similar to members of a family of hypothetical mycobacterial proteins including Rv2871, Rv1241, Rv2132,Rv3321c, Rv1113, Rv0657, Rv1560, etc. FASTA scores: sptr|Q49787|Q49787 B2126_C2_217 (97 aa) opt: 197, E(): 2e-07; 57.1% identity in 56 aa overlap and Z95388|MTCY270_36 Mycobacterium tuberculosis cosmid (76 aa ) opt: 142, E(): 0.0011; 41.8% identity in 55 aa overlap. Q7TZ15 No virulence, detoxification, adaptation Rv2104c NC_002945.3 Mycobrowser_v2 CDS 2299087 2300622 . + 0 Mb2085 CONSERVED HYPOTHETICAL PROTEIN Mb2085, -, len: 511 aa. Equivalent to Rv2059, len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Conserved hypothetical protein. Some similarity to EWLA protein gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k (304 aa), FASTA score, opt: 287 E(): 6.9e-09; 27.2% identity in 228 aa overlap. There appears to be a frameshift in this ORF around position 3315980 that causes an overlap with next ORF. C-terminal end of protein may be wrong. No error can be found to account for this. Q7TZ30 No conserved hypotheticals Rv2059 NC_002945.3 Mycobrowser_v2 CDS 2300192 2300593 . + 0 Mb2086 Possible conserved integral membrane protein Mb2086, -, len: 133 aa. Equivalent to Rv2060, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 133 aa overlap). Possible conserved integral membrane protein smaller than but similar to several hypothetical bacterial proteins e.g. >emb|CAC29843.1| (AL583918) putative ABC-transporter transmembrane protein [Mycobacterium leprae] Length = 286 and P44691|YEBI_HAEIN (261 aa). FASTA scores: P44691|YEBI_HAEIN HYPOTHETICAL PROTEIN HI0407 (261 aa) opt: 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap. Maybe frameshift upstream at position 3315980 but no error can be found to account for this. Q7VER9 No cell wall and cell processes Rv2060 NC_002945.3 Mycobrowser_v2 CDS 2300594 2300998 . - 0 Mb2087c conserved protein Mb2087c, -, len: 134 aa. Equivalent to Rv2061c,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Conserved hypothetical protein. Similar to conserved hypothetical proteins from Mycobacterium leprae (128 aa) and Streptomyces coelicolor (153 aa). Smith-Waterman scores: >emb|CAC30396.1| (AL583922) [Mycobacterium leprae], Expect = 7e-47, Identities = 92/131 (70%); >emb|CAC14932.1| (AL449216) [Streptomyces coelicolor], Expect = 6e-19 Identities = 48/124 (38%). Q7TZ29 No conserved hypotheticals Rv2061c NC_002945.3 Mycobrowser_v2 CDS 2301082 2304666 . - 0 Mb2088c cobN cobalamin biosynthesis protein cobn Mb2088c, cobN, len: 1194 aa. Equivalent to Rv2062c,len: 1194 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1194 aa overlap). Probable cobN,cobalamin biosynthesis protein - very similar to COBN_PSEDE P29929 cobn protein. Pseudomonas denitrifica (1275 aa), FASTA scores, opt: 831, E(): 0, (37.5% identity in 983 aa overlap). Also similar to several Mg2+-chelatases e.g. H64479 magnesium chelatase subunit homolog (1226 aa )opt: 962 E(): 0; (27.3% identity in 846 aa overlap) Q7VER8 No NC_002945.3 Mycobrowser_v2 CDS 2304744 2304977 . + 0 Mb2089 maze7 antitoxin maze7 Mb2089, -, len: 77 aa. Equivalent to Rv2063, len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Conserved hypothetical protein, showing some similarity to other conserved hypothetical proteins e.g. AL109974_2|SCF34.02c hypothetical protein from Streptomyces coelicolor (133 aa), FASTA scores: opt: 102, E(): 1.7, (34.35% identity in 67 aa overlap); and AE005182_1 from Escherichia coli strain O157:H7 (77 aa), FASTA scores: opt: 95, E(): 3.3,(34.85% identity in 66 aa overlap). This ORF replaces previous Rv2063c on other strand. Q7TZ28 No virulence, detoxification, adaptation Rv2063 NC_002945.3 Mycobrowser_v2 CDS 2304970 2305380 . + 0 Mb2089A mazF7 Possible toxin MazF7 Mb2089A, len: 136 aa. Equivalent to Rv2063A len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazF7 toxin, part of toxin-antitoxin (TA) operon with Rv2063 (See Pandey and Gerdes, 2005). X2BJD2 No virulence, detoxification, adaptation Rv2063A NC_002945.3 Mycobrowser_v2 CDS 2305364 2306455 . + 0 Mb2090 cobG precorrin-3b synthase cobg Mb2090, cobG, len: 363 aa. Equivalent to Rv2064,len: 363 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 363 aa overlap). Possible cobG,cobalamin biosynthesis protein. Some similarity to COBG_PSEDE P21637 cobg protein. pseudomonas (459 aa) FASTA scores, opt: 240, E(): 1.3e-08, (27.5% identity in 407 aa overlap); contains PS01156 TonB-dependent receptor proteins signature 2 Q7VER7 No intermediary metabolism and respiration Rv2064 NC_002945.3 Mycobrowser_v2 CDS 2306465 2307091 . + 0 Mb2091 cobH precorrin-8x methylmutase cobh (aka precorrin isomerase) Mb2091, cobH, len: 208 aa. Equivalent to Rv2065,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Probable cobH,precorrin-8X methylmutase (aka precorrin isomerase) (EC 5.4.1.2), similar to COBH_PSEDE P21638 precorrin isomerase (210 aa), FASTA scores: opt: 750, E(): 0, (55.4% identity in 202 aa overlap). X2BJM5,P63840 No intermediary metabolism and respiration Rv2065 NC_002945.3 Mycobrowser_v2 CDS 2307088 2308614 . + 0 Mb2092 cobI Probable bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase Mb2092, cobI, len: 508 aa. Equivalent to Rv2066,len: 508 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 508 aa overlap). Probable CobI-CobJ fusion protein, S-adenosyl-L-methionine-precorrin-2 methyl transferase and precorrin-3 methylase (EC 2.1.1.-). Similar in N-terminal half (aa 1-240) to COBI_PSEDE|P21639, S-adenosyl-L-methionine-precorrin-2 methyl transferase (244 aa), FASTA scores: opt: 759, E(): 4.4e-34, (49.2% identity in 238 aa overlap); and in C-terminal half (aa 240-508) to P21640|COBJ_PSEDE PRECORRIN-3 METHYLASE (EC 2.1.1.-) (254 aa), FASTA scores: opt: 695, E(): 0, (45.3% identity in 258 aa overlap). X2BJX9,P66878 No intermediary metabolism and respiration Rv2066 NC_002945.3 Mycobrowser_v2 CDS 2308560 2309783 . - 0 Mb2093c conserved protein Mb2093c, -, len: 407 aa. Equivalent to Rv2067c,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Conserved hypothetical protein, some similarity to YAT1_SYNP6 P08442 atp synthase subunits region ORF 1. (417 aa), FASTA scores, opt: 373, E(): 4.9e-18, (27.7% identity in 358 aa overlap) X2BJY9 No conserved hypotheticals Rv2067c NC_002945.3 Mycobrowser_v2 CDS 2309799 2310722 . - 0 Mb2094c blaC CLASS A BETA-LACTAMASE BLAC Mb2094c, blaC, len: 307 aa. Equivalent to Rv2068c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). blaC, class A beta-lactamase (EC 3.5.2.6) (see citation below), similar to e.g. BLAC_NOCLA Q06316 beta-lactamase precursor (302 aa), FASTA scores, opt: 860, E(): 0, (50.2% identity in 283 aa overlap); eyc. Contains PS00013 Prokaryotic lipid attachment site near N-terminus, and PS00146 Beta-lactamase class-A active site. BELONGS TO THE CLASS-C BETA-LACTAMASE FAMILY. X2BJD5,P0A5I7 No NC_002945.3 Mycobrowser_v2 CDS 2310857 2311414 . + 0 Mb2095 sigC rna polymerase sigma factor, ecf subfamily,sigc Mb2095, sigC, len: 185 aa. Equivalent to Rv2069,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Probable sigC, RNA polymerase sigma factor (see citation below), with similarity to SIGX_BACSU|P35165 probable RNA polymerase sigma factor from Bacillus subtilis (194 aa), FASTA scores: opt: 218, E(): 4.1e-07, (32.6% identity in 129 aa overlap). Belongs to ECF subfamily. X2BK16,P66810 No information pathways Rv2069 NC_002945.3 Mycobrowser_v2 CDS 2325894 2326124 . + 0 Mb2114 CONSERVED HYPOTHETICAL PROTEIN Mb2114, -, len: 76 aa. Equivalent to Rv2087, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 76 aa overlap). Conserved hypothetical protein, with low similarity to transposases; ORFs Rv2085,Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-45 aa). Q7TZ21 No insertion seqs and phages Rv2087 NC_002945.3 Mycobrowser_v2 CDS 2359670 2360152 . - 0 Mb2144c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2144c, -, len: 160 aa. Equivalent to Rv2120c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Probable conserved integral membrane protein, similar to hypothetical protein from Mesorhizobium loti (153 aa). Smith-Waterman scores: NP_104030.1 hypothetical protein [Mesorhizobium loti] >gi|14023209|dbj|BAB49816.1| (AP003000) Identities = 50/135 (37%). Q7TZ06 No cell wall and cell processes Rv2120c NC_002945.3 Mycobrowser_v2 CDS 2311404 2312099 . - 0 Mb2096c cobK precorrin-6x reductase cobk Mb2096c, cobK, len: 231 aa. Similar to Rv2070c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 227 aa overlap). Probable cobK,precorrin-6x reductase (EC 1.3.1.54), similar to e.g. L21196|g347169|RERCOBLMK3 RERCOBLMKN from Rhodococcus sp. NI86/21 (248 aa), FASTA scores: opt: 792, E(): 0, (53.6% identity in 250 aa overlap). Also similarity to CBIJ_SALTY|Q05591 cbij protein from Salmonella typhimurium (263 aa), FASTA scores: opt: 166, E(): 9e-0 5, (26.7% identity in 258 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-a) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (231 aa versus 244 aa). Q7VER6 No NC_002945.3 Mycobrowser_v2 CDS 2312136 2312891 . - 0 Mb2097c cobM precorrin-3 methylase cobm (precorrin-4 c11-methyltransferase) Mb2097c, cobM, len: 251 aa. Equivalent to Rv2071c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Probable cobM,precorrin-3 methylase (EC 2.1.1.133), similar to e.g. L21196|g347169|RERCOBLMK2 RERCOBLMK from Rhodococococcus sp. NI86/21 (249 aa), FASTA scores: opt: 992, E(): 0,(62.4% identity in 245 aa overlap) and to COBM_ PSEDE|P21922 precorrin-3 methylase (253 aa), FASTA scores: opt: 863, E(): 0, (54.6% identity in 249 aa overlap). Contains PS00839 Uroporphyrin-III C-methyltransferase signature 1, and PS00840 Uroporphyrin-III C-methyltransferase signature 2. Q7VER5 No NC_002945.3 Mycobrowser_v2 CDS 2312888 2313772 . - 0 Mb2098c cobLb Probable precorrin-6y methyltransferase CobLb [SECOND PART] Mb2098c, cobLb, len: 294 aa. Equivalent to 3' end of Rv2072c, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 294 aa overlap). Probable cobL, methyl transferase (EC 2.1.1.132), similar to L21196|g347169|RERCOBLMK1 from Rhodocococcus sp. NI86/21 (447 aa), FASTA scores: opt: 892; E(): 0; (50.1% identity in 369 aa overlap), and to COBL_PSEDE|P21921 precorrin-6y methylase (413 aa), FASTA scores: opt: 830, E(): 0, (40.6% identity in 404 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 2029 bp deletion (H37Rv2.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb. Q7VER4 No NC_002945.3 Mycobrowser_v2 CDS 2313714 2313902 . - 0 Mb2099c cobLa Probable precorrin-6y methyltransferase CobLa [FIRST PART] Mb2099c, cobLa, len: 62 aa. Similar to 5' end of Rv2072c, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv, (97.727% identity in 44 aa overlap). Probable cobL, methyl transferase (EC 2.1.1.132), similar to L21196|g347169|RERCOBLMK1 from Rhodocococcus sp. NI86/21 (447 aa), FASTA scores: opt: 892; E(): 0; (50.1% identity in 369 aa overlap), and to COBL_PSEDE|P21921 precorrin-6y methylase (413 aa), FASTA scores: opt: 830,E(): 0, (40.6% identity in 404 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 2029 bp (H37Rv2.2330073-2332101-*) (RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb. Q7VER3 No NC_002945.3 Mycobrowser_v2 CDS 2313977 2314765 . - 0 Mb2100c Possible hypothetical exported or envelope protein Mb2100c, -, len: 262 aa. Equivalent to 5' end of Rv2075c, len: 487 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 259 aa overlap). Possibly exported or envelope protein; has potential signal peptide at N-terminus and hydrophobic stretch around residue 430. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 2029 bp deletion (RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7VER2 No NC_002945.3 Mycobrowser_v2 CDS 2316181 2316480 . - 0 Mb2103c CONSERVED HYPOTHETICAL PROTEIN Mb2103c, -, len: 99 aa. Equivalent to Rv2077A, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein, similar to P95263|Rv1951c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA scores: opt: 271, E(): 1.5e-11, (51.04% identity in 97 aa overlap); and some similarity with P95012|Rv2541 HYPOTHETICAL ALANINE RICH PROTEIN from Mycobacterium tuberculosis (135 aa), FASTA scores: opt: 140, E(): 0.014,(32.95% identity in 88 aa overlap). Q7TZ27 No conserved hypotheticals Rv2077A NC_002945.3 Mycobrowser_v2 CDS 2317241 2319211 . + 0 Mb2105 CONSERVED HYPOTHETICAL PROTEIN Mb2105, -, len: 656 aa. Equivalent to Rv2079, len: 656 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 656 aa overlap). Conserved hypothetical protein; part of Mycobacterium tuberculosis protein family with Rv2542, Rv2077c, Rv2797c, Rv0963c, Rv1949c. Contains PS00120 Lipases, serine active site Q7TZ26 No conserved hypotheticals Rv2079 NC_002945.3 Mycobrowser_v2 CDS 2319192 2319755 . + 0 Mb2106 lppJ lipoprotein lppj Mb2106, lppJ, len: 187 aa. Equivalent to Rv2080,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Possible lppJ,lipoprotein; contains prokayotic lipoprotein modification site (PS00013) and signal sequence at N-terminus. X2BJN3,Q7VER1 No cell wall and cell processes Rv2080 NC_002945.3 Mycobrowser_v2 CDS 2319951 2320394 . - 0 Mb2107c conserved transmembrane protein Mb2107c, -, len: 147 aa. Equivalent to Rv2081c,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 147 aa overlap). Possible transmembrane unknown protein. Hydrophobic stretch from aa 32-54. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp insertion (*-ggg) leads to a slightly longer product compared t its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa). Q7TZ25 No cell wall and cell processes Rv2081c NC_002945.3 Mycobrowser_v2 CDS 2347842 2348138 . + 0 Mb2131 PE22 pe family protein pe22 Mb2131, PE22, len: 98 aa. Equivalent to Rv2107,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Member of mycobacterial PE family e.g. Y03A_MYCTU Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores; opt: 214 E(): 1.3e-14, 39.8% identity in 93 aa overlap Q7VEQ9 No PE/PPE Rv2107 NC_002945.3 Mycobrowser_v2 CDS 2320598 2322763 . + 0 Mb2108 CONSERVED HYPOTHETICAL PROTEIN Mb2108, -, len: 721 aa. Equivalent to Rv2082, len: 721 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 721 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0029, and to Rv3899c and Rv3900c which may be frameshifted. Q7TZ24 No conserved hypotheticals Rv2082 NC_002945.3 Mycobrowser_v2 CDS 2323697 2324692 . + 0 Mb2110 HYPOTHETICAL PROTEIN Mb2110, -, len: 331 aa. Similar to 5' end of Rv2084, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 284 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts,Mb2110 and Mb2111. Q7TZ22 No NC_002945.3 Mycobrowser_v2 CDS 2324927 2325232 . + 0 Mb2112 CONSERVED HYPOTHETICAL PROTEIN Mb2112, -, len: 101 aa. Equivalent to Rv2085, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Conserved hypothetical protein, similar to YI32_MYCTU P19772 insertion element IS986 hypothetical 6.6 kda protein (59 aa), FASTA scores, opt: 119, E(): 0.002 9, (36.4% identity in 55 aa overlap); ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Contains possible helix-turn-helix motif at aa 33 to 54,(+3.11 SD). X2BJZ0 No insertion seqs and phages Rv2085 NC_002945.3 Mycobrowser_v2 CDS 2325211 2325816 . + 0 Mb2113 CONSERVED HYPOTHETICAL PROTEIN Mb2113, -, len: 201 aa. Equivalent to Rv2086, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Conserved hypothetical protein: low similarity to transposases; ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-16 aa). X2BK12 No insertion seqs and phages Rv2086 NC_002945.3 Mycobrowser_v2 CDS 2326311 2328080 . + 0 Mb2115 pknJ transmembrane serine/threonine-protein kinase j pknj (protein kinase j) (stpk j) Mb2115, pknJ, len: 589 aa. Equivalent to Rv2088,len: 589 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 589 aa overlap). Probable pknJ,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to other serine/threonine-protein kinases e.g. PKWA_THECU|P49695 putative serine/threonine-protein kinase (742 aa), FASTA scores: opt: 457, E(): 2.7e-15, (26.0% identity in 578 aa overlap); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. X2BK37,P65733 No regulatory proteins Rv2088 NC_002945.3 Mycobrowser_v2 CDS 2348194 2348925 . + 0 Mb2132 PPE36 ppe family protein ppe36 Mb2132, PPE36, len: 243 aa. Equivalent to Rv2108,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 243 aa overlap). N-terminus is similar to N-terminal region of Mycobacterium tuberculosis PPE family proteins eg. YX23_MYCTU Q10813 hypothetical 41.1 kd protein cy274.23 (404 aa), FASTA scores; opt: 431, E(): 3.9e-32, 44.0% identity in 166 aa overlap Q7VEQ8 No NC_002945.3 Mycobrowser_v2 CDS 2366691 2367569 . + 0 Mb2149 CONSERVED HYPOTHETICAL PROTEIN Mb2149, -, len: 292 aa. Equivalent to Rv2125, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 292 aa overlap). Conserved hypothetical protein. Corresponds to Mycobacterium leprae hypothetical protein e.g. TR:Q49797 B2126_F1_36 (317 aa), FASTA scores; opt: 1648, E(): 0, 84.1% identity in 290 aa overlap. Very similar to Mycobacterium tuberculosis hypothetical protein Rv2714 Q7TZ05 No conserved hypotheticals Rv2125 NC_002945.3 Mycobrowser_v2 CDS 2328097 2329224 . - 0 Mb2116c pepE dipeptidase pepe Mb2116c, pepE, len: 375 aa. Equivalent to Rv2089c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Probable pepE,dipeptidase, similar to e.g. PEPQ_LACDL P46545, xaa-pro dipeptidase (368 aa), FASTA scores, opt: 617, E(): 5.1 e-32, (34.7% identity in 363 aa overlap); contains PS00491 Aminopeptidase P and proline dipeptidase signature. Also similar to Mycobacterium tuberculosis peptidases Rv2861c,Rv0734, Rv2535c. X2BJP1,P65811 No NC_002945.3 Mycobrowser_v2 CDS 2379118 2380191 . + 0 Mb2163 pyrD probable dihydroorotate dehydrogenase pyrd Mb2163, pyrD, len: 357 aa. Equivalent to Rv2139,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). Probable pyrD,dihydroorotate dehydrogenase (EC 1.3.3.1); contains dihydroorotate dehydrogenase signatures 1 and 2 (PS00911,PS00912). FASTA best: PYRD_MYCLE P46727 dihydroorotate dehydrogenase (309 aa) opt: 1653, E(): 0; (82.6% identity in 304 aa overlap) X2BK73,P65909 No intermediary metabolism and respiration Rv2139 NC_002945.3 Mycobrowser_v2 CDS 2329273 2330397 . + 0 Mb2117 probable 5'-3' exonuclease Mb2117, -, len: 374 aa. Equivalent to Rv2090, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(94.7% identity in 393 aa overlap). Probable 5'-3' exonuclease, similar to exonuclease part of DNA polymerase, e.g. DPO1_MYCTU Q07700 DNA polymerase I (EC 2.7.7.7) (pol i) (904 aa), FASTA scores, opt: 461, E(): 1.2e-17, (38.7% identity in 292 aa overlap). BELONGS TO FAMILY A OF DNA POLYMERASES. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 57 bp in-frame deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (374 aa versus 393 aa). Q7VER0 No information pathways Rv2090 NC_002945.3 Mycobrowser_v2 CDS 2330401 2331135 . - 0 Mb2118c Probable membrane protein Mb2118c, -, len: 244 aa. Equivalent to Rv2091c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable membrane protein; contains potential transmembrane region. Repetitive ORF. X2BK18,P64940 No cell wall and cell processes Rv2091c NC_002945.3 Mycobrowser_v2 CDS 2331177 2333897 . - 0 Mb2119c helY atp-dependent dna helicase hely Mb2119c, helY, len: 906 aa. Equivalent to Rv2092c,len: 906 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 906 aa overlap). Probable helY, DNA helicase (EC 3.6.1.-), with similarity to YJF0_YEAST P47047 hypothetical helicase in tdh1-gyp6 intergenic region, (1073 aa), FASTA scores, opt: 1004, E(): 0, (29.0% identity in 970 aa o verlap); contains PS00017 ATP/GTP-binding site motif A, PS00402 Binding-protein-dependent transport systems inner membrane comp signature. BELONGS TO THE SKI2 SUBFAMILY OF HELICASES. Q7TZ20 No NC_002945.3 Mycobrowser_v2 CDS 2484884 2485309 . - 0 Mb2256A vapC16 Possible toxin VapC16 Mb2256A, len: 141 aa. Equivalent to Rv2231A len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapC16, toxin, part of toxin-antitoxin (TA) operon with Rv2231B (See Pandey and Gerdes, 2005). Nucleotide position 2505919 in the genome sequence has been corrected, A:G resulting in A81A. X2BKH1 No virulence, detoxification, adaptation Rv2231A NC_002945.3 Mycobrowser_v2 CDS 2333946 2334872 . - 0 Mb2120c tatC sec-independent protein translocase transmembrane protein tatc Mb2120c, tatC, len: 308 aa. Equivalent to Rv2093c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable tatC,transmembrane protein, component of twin-arginine translocation protein export system (see citation below for more information), equivalent to U00017|U00017_1 from Mycobacterium leprae (317 aa), FASTA scores: opt: 1722,E(): 0, (84.5% identity in 310 aa overlap). Similarity to others e.g. P27857|TATC_ECOLI|MTTB|B3839|Z5360|ECS4768 Sec-independent protein translocase protein from E. coli strain K12 and O157:H7 (258 aa), FASTA scores: opt: 344,E(): 6e-16, (32.5% identity in 265 aa overlap). BELONGS TO THE TATC FAMILY. X2BK44,P66896 No NC_002945.3 Mycobrowser_v2 CDS 2334889 2335140 . - 0 Mb2121c tatA sec-independent protein translocase membrane-bound protein tata Mb2121c, tatA, len: 83 aa. Equivalent to Rv2094c,len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Probable tatA,membrane-bound protein, component of twin-arginine translocation protein export system (see citation below for more information), equivalent to U00017_2 from Mycobacterium leprae (88 aa), FASTA scores: opt: 392, E(): 2e-20, (68.2% identity in 88 aa overlap). Similarity to others e.g. P27856|O65938|TATA_ECOLI SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN from E. coli strains K12 and O157:H7 (261 aa), FASTA scores: opt: 111, E(): 0.25, (28.0 % identity in 75 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE TATA/E FAMILY. X2BJP6,P66890 No NC_002945.3 Mycobrowser_v2 CDS 2335208 2336158 . - 0 Mb2122c pafc proteasome accessory factor c pafc Mb2122c, -, len: 316 aa. Equivalent to Rv2095c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 316 aa overlap). Conserved hypothetical protein. Highly similar to ML1330 P54075|YY35_MYCLE HYPOTHETICAL 27.0 KD PROTEIN (247 aa) opt: 1127 E(): 0,(78.4% identity in 227 aa overlap). Also similar to ORF11(1) of Rhodococcus erythropolis. FASTA score: Z82004|REZ820043 REZ82004 NID: g1666179 - Rhodococcus (326 aa) opt: 624 E(): 1.1e-30; (56.7% identity in 319 aa overlap). Contains possible helix-turn-helix motif at aa 25-46, ( +2.92 SD) Q7TZ19 No intermediary metabolism and respiration Rv2095c NC_002945.3 Mycobrowser_v2 CDS 2336155 2337153 . - 0 Mb2123c pafb proteasome accessory factor b pafb Mb2123c, -, len: 332 aa. Equivalent to Rv2096c,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 332 aa overlap). Conserved hypothetical protein. Highly similar to ML1329,P54076|YY36_MYCLE HYPOTHETICAL 35.4 KD PROTEIN B21 (331 aa) opt: 1676 E(): 0; (80.2% identity in 329 aa overlap) and to ORF10(1) of Rhodococcus erythropolis,Z82004|REZ820042 REZ 82004 NID: g1666179 (330 aa) opt: 1232, E(): 0; 59.9% identity in 332 aa overlap X2BK22 No intermediary metabolism and respiration Rv2096c NC_002945.3 Mycobrowser_v2 CDS 3111224 3112441 . - 0 Mb2872c cysG POSSIBLE MULTIFUNCTIONAL ENZYME SIROHEME SYNTHASE CYSG: UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN III METHYLASE) (SUMT) (UROPORPHYRINOGEN III METHYLASE) (UROM) + PRECORRIN-2 OXIDASE + FERROCHELATASE Mb2872c, cysG, len: 405 aa. Equivalent to Rv2847c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Possible cysG,multifunctional enzyme, siroheme synthase containing uroporphyrin-iii c-methyltransferase (EC 2.1.1.107),precorrin-2 oxidase (EC 1.-.-.-) and ferrochelatase (EC 4.99.1.-). C-terminus highly similar to many uroporphyrin-iii c-methyltransferases e.g. Q51720|COBA UROPORPHYRINOGEN III METHYLTRANSFERASE from Propionibacterium freudenreichii (257 aa), FASTA scores: opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa overlap); Q9HMY4|UROM|VNG2331G S-ADENOSYL-L-METHIONINE:UROPORPHYRINOGEN III METHYLTRANSFERASE from Halobacterium sp. strain NRC-1 (246 aa), FASTA scores: opt: 704, E(): 3.1e-35, (49.4% identity in 245 aa overlap); P42437|NASF_BACSU|NASBE UROPORPHYRIN-III C-METHYLTRANSFERASE from Bacillus subtilis (483 aa), FASTA scores: opt: 610, E(): 2.4e-29,(42.1% identity in 240 aa overlap); etc. And highly similar over entire length to other proteins e.g. Q9L1C9|SCL11.09c UROPORPHYRINOGEN III METHYLTRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1481, E(): 5.6e-82, (58.45% identity in 409 aa overlap); Q9I0M7|CYSG|PA2611 SIROHEME SYNTHASE from Pseudomonas aeruginosa (465 aa), FASTA scores: opt: 609, E(): 2.7e-29,(34.7% identity in 444 aa overlap); P11098|CYSG_ECOLI|B3368|Z4729|ECS4219 SIROHEME SYNTHASE from Escherichia coli stains O157:H7 and K12 (457 aa),FASTA scores: opt: 543, E(): 9.1e-27, (31.3% identity in 450 aa overlap); etc. BELONGS TO A FAMILY THAT GROUPS SUMT, CYSG, CBIF/COBM AND CBIL/COBI. Note that previously known as cysG2. Q7TXQ3 No NC_002945.3 Mycobrowser_v2 CDS 2337162 2338520 . - 0 Mb2124c pafa proteasome accessory factor a pafa Mb2124c, -, len: 452 aa. Equivalent to Rv2097c,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 452 aa overlap). Conserved hypothetical protein. Similarity to YTH6_ RHOSO P43484 hypothetical protein in thcr 5' region (333 aa), FASTA scores opt: 738, E(): 0, (38.5% identity in 330 aa overlap). Also highly similar to Mycobacterium leprae protein ML1328, P54077|YY37_MYCLE HYPOTHETICAL 38.1 KD PROTEIN (336 aa) opt: 1985 E(): 0; (96.4% identity in 307 aa overlap) X2BJF1,P64944 No intermediary metabolism and respiration Rv2097c NC_002945.3 Mycobrowser_v2 CDS 2338572 2340047 . - 0 Mb2125c pe21 pe-pgrs family protein pe_pgrs36 Mb2125c, PE_PGRS36, len: 491 aa. Equivalent to Rv2099c (PE21) and Rv2098c (PE_PGRS36), len: 58 aa and 433 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 58 aa overlap and 99.8% identity in 433 aa overlap). Rv2098c|PE_PGRS36: Member of Mycobacterium tuberculosis PE-family, PGRS sub-family. Frameshifted near N-terminus. Rv2099c|PE21: 5'-end of Rv2098c (MTCY49.38c),then frameshifts. Sequence has been checked, no errors found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (ggc-*). X2BK49 No NC_002945.3 Mycobrowser_v2 CDS 2340230 2341882 . + 0 Mb2126 CONSERVED HYPOTHETICAL PROTEIN Mb2126, -, len: 550 aa. Equivalent to Rv2100, len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 550 aa overlap). Conserved hypothetical protein. Member of Mycobacterium tuberculosis 13E12 repeat family with Rv1148c, Rv1945, Rv3467, Rv0094c,Rv1128c, Rv1587c, Rv1702c, Rv3466, Rv1588c. X2BJP9 No insertion seqs and phages Rv2100 NC_002945.3 Mycobrowser_v2 CDS 2354259 2354882 . + 0 Mb2138 conserved protein Mb2138, -, len: 207 aa. Equivalent to Rv2114, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Unknown Q7TZ10 No conserved hypotheticals Rv2114 NC_002945.3 Mycobrowser_v2 CDS 2342081 2345122 . + 0 Mb2127 helZ PROBABLE HELICASE HELZ Mb2127, helZ, len: 1013 aa. Equivalent to Rv2101,len: 1013 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1013 aa overlap). Probable helZ,helicase (EC 3.6.-.-), similar to many e.g. PCC6803|P74552|SLL1366 HELICASE OF THE SNF2/RAD54 FAMILY from Synechocystis sp. strain PCC 6803 (1039 aa), FASTA scores: opt: 2015, E(): 0, (38.4% identity in 1063 aa overlap); etc. Q7TZ18 No NC_002945.3 Mycobrowser_v2 CDS 2556823 2557014 . - 0 Mb2331c HYPOTHETICAL GLYCINE RICH PROTEIN Mb2331c, -, len: 63 aa. Equivalent to Rv2307A, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Hypothetical unknown protein. Q7TYV1 No conserved hypotheticals Rv2307A NC_002945.3 Mycobrowser_v2 CDS 2345115 2345948 . + 0 Mb2128 CONSERVED HYPOTHETICAL PROTEIN Mb2128, -, len: 277 aa. Equivalent to hypothetical protein MT2162 from Mycobacterium tuberculosis strain CDC1551 (100% identity with 277 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al.,2013). Mb---- transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BK29 No NC_002945.3 Mycobrowser_v2 CDS 2345927 2346361 . - 0 Mb2129c vapc37 possible toxin vapc37. contains pin domain. Mb2129c, -, len: 144 aa. Equivalent to Rv2103c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Conserved hypothetical protein, similar to hypothetical mycobacterial proteins belonging to family, includes Rv0749, Rv0277c, Rv2530c, Rv3320c, Rv2494, Rv2872, Rv0617,Rv1242 etc. FASTA scores: sptr|Q49793|Q49793 B2126_C3_261 (97 aa) opt: 331, E(): 4.8e-18; 59.4% identity in 96 aa overlap and gp|Z74024|MTCY274_3 Mycobacterium tuberculosis cosmid (147 aa) opt: 234, E(): 1.2e-10; 34.8% identity in 141 aa overlap. Q7TZ16 No virulence, detoxification, adaptation Rv2103c NC_002945.3 Mycobrowser_v2 CDS 2349465 2350211 . - 0 Mb2133c prcA proteasome alpha subunit prca; assembles with beta subunit prcb. Mb2133c, prcA, len: 248 aa. Equivalent to Rv2109c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 248 aa overlap). prcA, proteasome alpha-type subunit 1, highly similar to TR:Q53080 (EMBL:U26421 ) proteasome alpha-type subunit 1 from Rhodococcus (259 aa), FASTA scores; opt: 1035, E(): 0,67.2% identity in 247 aa overlap. X2BK34,Q7TZ14 No NC_002945.3 Mycobrowser_v2 CDS 2350208 2351083 . - 0 Mb2134c prcB proteasome beta subunit prcb; assembles with alpha subunit prca. Mb2134c, prcB, len: 291 aa. Equivalent to Rv2110c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). prcB, proteasome beta-type subunit 2, highly similar to eg. TR:Q53083 (EMBL:U264 22) proteasome beta-type subunit 2 from Rhodococcus (292 aa), FASTA scores; opt: 1103, E(): 0,64.5% identity in 262 aa overlap. X2BJF5,Q7TZ13 No NC_002945.3 Mycobrowser_v2 CDS 2351387 2352994 . - 0 Mb2136c dop deamidase of pup dop Mb2136c, -, len: 535 aa. Similar to Rv2112c, len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 532 aa overlap). Conserved hypothetical protein. Highly similar to a hypothetical protein TR:Q53081 (EMBL:U26422) (499 aa) upstream of Rhodococcus proteasome beta-type subunit 1, FASTA scores opt: 2832 E(): 0, 85.3% identity in 502 aa overlap. Also some similarity to Mycobacterium tuberculosis hypothetical protein Rv2097c (MTCY49.37c, 38.2% identity in 419 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa). Q7TZ11 No NC_002945.3 Mycobrowser_v2 CDS 2353055 2354248 . + 0 Mb2137 Probable integral membrane protein Mb2137, -, len: 397 aa. Equivalent to Rv2113, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 397 aa overlap). Probable integral membrane protein. Q7VEQ7 No cell wall and cell processes Rv2113 NC_002945.3 Mycobrowser_v2 CDS 2354886 2356715 . - 0 Mb2139c mpa mycobacterial proteasome atpase mpa Mb2139c, -, len: 609 aa. Equivalent to Rv2115c,len: 609 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 609 aa overlap). Probable ATPase (EC 3.6.1.-), similar to e.g. YB56_METJA Q58556 cell division cycle protein 48 homolog (903 aa), FASTA scores; opt: 423,E(): 8.1e-32, 45.8% identity in 249 aa overlap. Contains PS00674 AAA-protein family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also some similarity to other Mycobacterium tuberculosis ATPases eg. Rv0435c and Rv3610c. Equivalent to Mycobacterium leprae U00 017|U00017_18 (609 aa), FASTA scores; opt: 3670 E(): 0; 92.9% identity in 609 aa overlap. X2BJF7,P63346 No cell wall and cell processes Rv2115c NC_002945.3 Mycobrowser_v2 CDS 2356996 2357565 . + 0 Mb2140 lppK conserved lipoprotein lppk Mb2140, lppK, len: 189 aa. Equivalent to Rv2116,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 189 aa overlap). Probable lppK,conserved lipoprotein, similar to Mycobacterium leprae B2126_F3_115 TR:Q49803 (194 aa), FASTA scores; opt: 624,E(): 3.1e-31, 51.6% identity in 190 aa overlap. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to Rv2376c. X2BK65,P65301 No cell wall and cell processes Rv2116 NC_002945.3 Mycobrowser_v2 CDS 2357573 2357866 . + 0 Mb2141 CONSERVED HYPOTHETICAL PROTEIN Mb2141, -, len: 97 aa. Equivalent to Rv2117, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein. Similar to hypothetical proteins from Mycobacterium leprae TR:Q49798 U2126J (97 aa), FASTA scores; opt: 554, E(): 0, 85.6% identity in 97 aa overlap,and Bacillus subtilis YLXP_BACSU P32730 hypothetical 10.7 kd protein (92 aa), FASTA scores; opt: 173, E(): 1.4e-11,34.1% identity in 82 aa overlap Q7TZ09 No conserved hypotheticals Rv2117 NC_002945.3 Mycobrowser_v2 CDS 2357895 2358737 . - 0 Mb2142c rna methyltransferase Mb2142c, -, len: 280 aa. Equivalent to Rv2118c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Possible S-adenosyl-l-methionine-dependent RNA methyltransferase (EC 2.1.1.-) (see citation below); corresponds to Mycobacterium leprae B2126_C1_165, similar to hypothetical proteins from several organisms e.g. Y134_METJA Q57598 hypothetical protein mj0134 (282 aa), FASTA scores; opt: 256, E(): 1e-13, FASTA scores; 30.2% identity in 285 aa overlap. The larger catalytic C-terminal domain binds the cofactor S-adenosyl-l-methionine (AdoMet) and is involved in the transfer of methyl group from AdoMet to the substrate. Q7TZ08 No intermediary metabolism and respiration Rv2118c NC_002945.3 Mycobrowser_v2 CDS 2358811 2359647 . + 0 Mb2143 CONSERVED HYPOTHETICAL PROTEIN Mb2143, -, len: 278 aa. Equivalent to Rv2119, len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium leprae hypothetical protein TR:Q49799 U2126V (212 aa), FASTA scores; opt: 1153, E(): 0, 83.6% identity in 195 aa overlap. Orthologs present in Rhodococcus erythropolis (gb|AAC68687.1|(AF088800) and Streptomyces emb|CAB59506.1|(AL132648) Q7TZ07 No conserved hypotheticals Rv2119 NC_002945.3 Mycobrowser_v2 CDS 2557099 2557530 . - 0 Mb2332c HYPOTHETICAL GLYCINE RICH PROTEIN Mb2332c, -, len: 143 aa. Equivalent to Rv2307B,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Hypothetical unknown Gly- rich protein. Equivalent to AAK46653 from Mycobacterium tuberculosis strain CDC1551 (133 aa) but longer 10 aa. Q7TYV0 No conserved hypotheticals Rv2307B NC_002945.3 Mycobrowser_v2 CDS 2360231 2361085 . - 0 Mb2145c hisG atp phosphoribosyltransferase hisg Mb2145c, hisG, len: 284 aa. Equivalent to Rv2121c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Probable hisG, ATP phosphoribosyltransferase (EC 2.4.2.17) (see citation below), similar to others e.g. HIS1_ECOLI|P10366 ATP phosphoribosyltransferase from Escherichia coli (299 aa),FASTA scores: opt: 351, E(): 4.5e-20, (31.8% identity in 289 aa overlap); etc. X2BK72,P60760 No NC_002945.3 Mycobrowser_v2 CDS 2361088 2361369 . - 0 Mb2146c hisE phosphoribosyl-amp pyrophosphatase hise Mb2146c, hisE, len: 93 aa. Equivalent to Rv2122c,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable hisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (EC 3.6.1.31) (see citation below), similar to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): 4e-08, (37.9% identity in 87 aa overlap); etc. Note that previously misnamed hisI. X2BJR8,P0A5B2 No NC_002945.3 Mycobrowser_v2 CDS 2524691 2525059 . + 0 Mb2295 probable conserved transmembrane protein Mb2295, -, len: 122 aa. Equivalent to Rv2272, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable conserved transmembrane PROTEIN, similar to YIDH_ECOLI P31445 hypothetical 12.8 kd protein (115 aa), FASTA scores, opt: 291, E(): 2.9e-14, (45.6% identity in 103 aa overlap),similar to MTCY339.37c, (35.0% identity in 100 aa overlap). X2BJS6,P64970 No cell wall and cell processes Rv2272 NC_002945.3 Mycobrowser_v2 CDS 2361496 2362890 . + 0 Mb2147 PPE37 ppe family protein ppe37 Mb2147, PPE37, len: 464 aa. Equivalent to Rv2123,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(97.9% identity in 473 aa overlap). PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa). Q7VEQ6 No NC_002945.3 Mycobrowser_v2 CDS 2362887 2366465 . - 0 Mb2148c metH 5-methyltetrahydrofolate--homocystein methyltransferase meth (methionine synthase, vitamin-b12 dependent isozyme) (ms) Mb2148c, metH, len: 1192 aa. Equivalent to Rv2124c,len: 1192 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1192 aa overlap). Probable metH,methionine synthase (EC 2.1.1.13), similar to many e.g. METH_ECOLI|P13009 5-methyltetrahydrofolate--homocystein methyltransferase from Escherichia coli (1226 aa), FASTA scores: opt: 1446, E(): 0, (32.1% identity in 1223 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO THE VITAMIN-B12 DEPENDENT METHIONINE SYNTHASE FAMILY. Q7VEQ5 No NC_002945.3 Mycobrowser_v2 CDS 2557623 2557805 . - 0 Mb2333c HYPOTHETICAL PROTEIN Mb2333c, -, len: 60 aa. Equivalent to Rv2307D, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Hypothetical unknown protein. Q7TYU9 No conserved hypotheticals Rv2307D NC_002945.3 Mycobrowser_v2 CDS 2367600 2368667 . - 0 Mb2150c PE_PGRS37 pe-pgrs family protein pe_pgrs37 Mb2150c, -, len: 256 aa. Equivalent to Rv2126c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 256 aa overlap). Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family e.g. MTCY441.04c (778 aa), FASTA scores; opt: 935, E(): 4.4e-18, 56.1% identity in 271 aa overlap Q7VEL2 No PE/PPE Rv2126c NC_002945.3 Mycobrowser_v2 CDS 2369014 2370483 . + 0 Mb2151 ansP1 l-asparagine permease ansp1 Mb2151, ansP1, len: 489 aa. Equivalent to Rv2127,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 489 aa overlap). Probable ansP1,L-asparagine permease, integral membrane protein highly similar to many eg. ANSP_ECOLI P77610 L-asparagine permease (L-asparagine transport protein) (516 aa), FASTA scores: opt: 1880, E(): 0, (60.3% identity in 463 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis permeases Rv0346c|MTCY13E10.06c, (72.1% identity in 473 aa overlap) and Rv1704c|MTCI125.26c|cycA. Contains PS00218 Amino acid permeases signature. SEEMS TO BELONG TO THE APC FAMILY. X2BJS3,Q7VEQ4 No NC_002945.3 Mycobrowser_v2 CDS 2370483 2370686 . + 0 Mb2152 conserved transmembrane protein Mb2152, -, len: 67 aa. Equivalent to Rv2128, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable conserved transmembrane protein. Q7TZ04 No cell wall and cell processes Rv2128 NC_002945.3 Mycobrowser_v2 CDS 2370706 2371587 . - 0 Mb2153c Probable oxidoreductase Mb2153c, -, len: 293 aa. Equivalent to Rv2129c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 293 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to many e.g. FABG_SYNY3|P73826 3-oxoacyl-[acyl-carrier protein] reductase (240 aa), FASTA scores: opt: 241, E(): 5.1e-17,(32.7% identity in 196 aa overlap); etc. Also similar to a number of other Mycobacterium tuberculosis oxidoreductases e.g. MTCY210.04 (34.1% identity in 217 aa overlap). Q7VEQ3 No intermediary metabolism and respiration Rv2129c NC_002945.3 Mycobrowser_v2 CDS 2380196 2380726 . - 0 Mb2164c TB18.6 conserved protein tb18.6 Mb2164c, TB18.6, len: 176 aa. Equivalent to Rv2140c, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 176 aa overlap). TB18.6,conserved hypothetical protein; shows good similarity to hypothetical proteins from Streptomyces coelicolor (177 aa; 58% identity) >emb|CAC32358.1| (AL583945) and to 17.1 kd Escherichia coli protein YbhB. FASTA best: YBHB_ECOLI P12994 hypothetical 17.1 kd protein (158 aa) opt: 465 E( ): 2e-23; (46.2% identity in 156 aa overlap). X2BJH2 No conserved hypotheticals Rv2140c NC_002945.3 Mycobrowser_v2 CDS 2376406 2377236 . - 0 Mb2160c Possible conserved transmembrane protein Mb2160c, -, len: 276 aa. Equivalent to Rv2136c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 276 aa overlap). Possible conserved transmembrane protein, very similar to hypothetical Mycobacterium leprae protein Q49783. FASTA best: Q49783 B2126_C2_190 opt: 1023, E(): 0; (82.4% identity in 187 aa over lap) similar to BACA_ECOLI P31054 bacitracin resistance protein (273 aa) opt: 477, E(): 7e-26, (35.6% identity in 267 aa overlap) X2BK90,Q7VEQ2 No cell wall and cell processes Rv2136c NC_002945.3 Mycobrowser_v2 CDS 2371613 2372857 . - 0 Mb2154c mshc cysteine:1d-myo-inosityl 2-amino-2-deoxy--d-glucopyranoside ligase mshc Mb2154c, cysS2, len: 414 aa. Equivalent to Rv2130c,len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Probable cysS2,cysteinyl-tRNA synthetase, similar to many e.g. SYC_ECOLI|P21888 cysteinyl-tRNA synthetase from Escherichia coli (461 aa), FASTA scores: opt: 535, E(): 0,(37.0% identity in 370 aa overlap); etc. Also similar to Mycobacterium tuberculosis cysS|Rv3580c|MTCY06G11.27c,(35.8% identity in 372 aa overlap). X2BJG6,P67018 No NC_002945.3 Mycobrowser_v2 CDS 2372915 2373718 . - 0 Mb2155c cysQ monophosphatase cysq Mb2155c, cysQ, len: 267 aa. Equivalent to Rv2131c,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 267 aa overlap). cysQ, equivalent to Mycobacterium leprae CYSQ_MYCLE P46726 cysQ protein homolog (289 aa). Contains inositol monophosphatase family signature 1 (PS00629), significance uncertain. FASTA best: CYSQ_MYCLE P4672 6 cysq protein homolog (289 aa) opt: 1374, E(): 0; (77.3% identity in 264 aa overlap) X2BK83,P65164 No NC_002945.3 Mycobrowser_v2 CDS 2373809 2374039 . + 0 Mb2156 CONSERVED HYPOTHETICAL PROTEIN Mb2156, -, len: 76 aa. Equivalent to Rv2132, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 76 aa overlap). Conserved hypothetical protein. Function unknown but belongs to Mycobacterium tuberculosis protein family including Rv2871, Rv1241,Rv3321c, Rv1113, Rv0657c, Rv1560, Rv2104c, etc. Similarity to Mycobacterium tuberculosis protein Rv2871 (AL021924|MTV020_4, 84 aa). FASTA score: opt: 142, E(): 0.00036; 41.8% identity in 55 aa overlap Q7TZ03 No conserved hypotheticals Rv2132 NC_002945.3 Mycobrowser_v2 CDS 2374249 2375037 . - 0 Mb2157c CONSERVED HYPOTHETICAL PROTEIN Mb2157c, -, len: 262 aa. Equivalent to Rv2133c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49774. FASTA best: Q49774 B2126_C1_150 (262 aa) opt: 1447, E(): 0; (79.0% identity in 262 aa overlap) Q7TZ02 No conserved hypotheticals Rv2133c NC_002945.3 Mycobrowser_v2 CDS 2375699 2376409 . - 0 Mb2159c conserved protein Mb2159c, -, len: 236 aa. Equivalent to Rv2135c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49773. FASTA best: Q49773 B2126_C1_148 opt: 1183, E() : 0; (74.8% identity in 250 aa overlap), also similar in C-terminus to PMG2_ECOLI P36942 probable phosphoglycerate mutase 2 (215 aa), FASTA scores; opt: 212, E(): 2.5e-07 27.9% identity in 190 aa overlap; and to Rv2228 and Rv2419c Q7TZ00 No conserved hypotheticals Rv2135c NC_002945.3 Mycobrowser_v2 CDS 2377300 2377713 . - 0 Mb2161c CONSERVED HYPOTHETICAL PROTEIN Mb2161c, -, len: 137 aa. Equivalent to Rv2137c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein. C-terminus is very similar to hypothetical Mycobacterium leprae protein B2126_C2_188 (150 aa). FASTA best: Q49782 B2126_C2_188. (150 aa) opt: 469, E(): 9.6e-28; (77.2% identity in 101 aa overlap) Q7TYZ9 No conserved hypotheticals Rv2137c NC_002945.3 Mycobrowser_v2 CDS 2377728 2378804 . + 0 Mb2162 lppL Probable conserved lipoprotein LppL Mb2162, lppL, len: 358 aa. Equivalent to Rv2138,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 358 aa overlap). Probable lppL,conserved lipoprotein, with appropriately placed lipoprotein signature (PS00013) strongly similar to hypothetical Mycobacterium leprae protein, Q49806. FASTA best: Q49806 B2126_F3_142. (298 aa) opt: 1495, E(): 0; (75.3% identity in 300 aa overlap). Q7VEQ1 No cell wall and cell processes Rv2138 NC_002945.3 Mycobrowser_v2 CDS 2380774 2382120 . - 0 Mb2165c conserved protein Mb2165c, -, len: 448 aa. Equivalent to Rv2141c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Conserved hypothetical protein. Shows some similarity to conserved hypothetical proteins and to acetylornithine deacetylase and succinyl-diaminopimelate desuccinylase and contains ArgE/dapE/ACY1/CPG2/yscS family signature 1 (PS00758). FASTA best: CBPS_YEAST P27614 carboxypeptidases precursor (576 aa) opt: 234, E(): 4.3e-08; (24.3% identity in 412 aa overlap). Previously named dapE2 Q7TYZ8 No intermediary metabolism and respiration Rv2141c NC_002945.3 Mycobrowser_v2 tRNA 2382501 2382586 . + 0 leuU leuU tRNA-Leu leuU, len: 86 nt. Equivalent to leuU, len: 86 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 86 nt overlap). leu-tRNA, anticodon gag. No NC_002945.3 Mycobrowser_v2 CDS 2382707 2383024 . - 0 Mb2166c pare2 possible toxin pare2 Mb2166c, -, len: 105 aa. Equivalent to Rv2142c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Hypothetical unknown protein. Q7TYZ7 No virulence, detoxification, adaptation Rv2142c NC_002945.3 Mycobrowser_v2 CDS 2383491 2384549 . + 0 Mb2167 CONSERVED HYPOTHETICAL PROTEIN Mb2167, -, len: 352 aa. Equivalent to Rv2143, len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein, strongly similar to two hypothetical mycobacterial proteins Rv2030c 2.1e-50 and Rv0571c from position 120 (Q50819; Q50111). FASTA best: Q50819 opt: 882, E() 0; (61.1% identity in 226 aa overlap). Also similar to AL021942|MTV039_9 (443 aa), FASTA scores: opt: 592, E(): 5e-30; 46.9% identity in 224 aa overlap Q7TYZ6 No conserved hypotheticals Rv2143 NC_002945.3 Mycobrowser_v2 CDS 2384679 2385035 . - 0 Mb2168c Probable transmembrane protein Mb2168c, -, len: 118 aa. Equivalent to Rv2144c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Probable transmembrane protein. Q7VEQ0 No cell wall and cell processes Rv2144c NC_002945.3 Mycobrowser_v2 CDS 2385130 2385912 . - 0 Mb2169c wag31 diviva family protein wag31 Mb2169c, wag31, len: 260 aa. Equivalent to Rv2145c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). wag31 (alternate gene name: ag84). Function unknown but corresponds to antigen 84 of Mycobacterium tuberculosis (wag31) (see first citation below). Predicted to contain significant amount of coiled coil structure. Some similarity to Rv1682 and Rv2927c. FASTA best: AG84_MYCTU P46816 antigen 84. X2BKA1,P0A5N3 No NC_002945.3 Mycobrowser_v2 CDS 2386180 2386470 . - 0 Mb2170c Possible conserved transmembrane protein Mb2170c, -, len: 96 aa. Equivalent to Rv2146c, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Possible conserved transmembrane protein, orthologs present in Mycobacterium leprae, ML0921 (96 aa) and Streptomyces coelicolor. Second start taken GTG alternative upstream but much less probable in TBparse. FASTA best: Q44935 SIMILAR TO A HYPOTHETICAL INTEGRAL MEMBRANE PROT EIN (97 aa) opt: 105,E(): 0.093; (25.3% identity in 87 aa overlap). >emb|CAC31302.1| (AL583920) possible membrane protein ML0921 [Mycobacterium leprae] E(): 5e-32 (76% identity in 96 aa overlap) Q7VEP9 No cell wall and cell processes Rv2146c NC_002945.3 Mycobrowser_v2 CDS 2386632 2387357 . - 0 Mb2171c CONSERVED HYPOTHETICAL PROTEIN Mb2171c, -, len: 241 aa. Equivalent to Rv2147c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins in Mycobacterium leprae ML0920 (210 aa) and Streptomyces coelicolor. FASTA scores: >emb|CAC31301.1| (AL583920) hypothetical protein ML0920 hypothetical protein (210 aa) opt: 1242, E(): 5.7e-74; 83.486% identity in 218 aa overlap X2BK20,Q7TYZ5 No conserved hypotheticals Rv2147c NC_002945.3 Mycobrowser_v2 CDS 2387354 2388130 . - 0 Mb2172c conserved protein Mb2172c, -, len: 258 aa. Equivalent to Rv2148c,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Conserved hypothetical protein; should belong to the YGGS/YBL036C/F09E5.8 family. FASTA best: AB003132|AB003132_5 Corynebacterium glutamicum gene (221 aa) opt: 440, E(): 2.3e-23; 42.8% identity in 236 aa overlap; and YPI1_VIBAL P52055 hypothetical protein in pilt-proc intergenic region in Vibrio alginolyticus. opt: 266, E(): 1.8e-11; 27.9% identity in 244 aa overlap. X2BK84 No conserved hypotheticals Rv2148c NC_002945.3 Mycobrowser_v2 CDS 2388136 2388888 . - 0 Mb2173c yfiH conserved protein yfih Mb2173c, yfiH, len: 250 aa. Equivalent to Rv2149c,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). yfiH; corresponds to hypothetical 25.3 kDa YfiH protein in ftsZ 3' region of Streptomyces griseus, and to YfiH proteins in other bacteria. Belongs to UPF0124 Family. FASTA best: YFIH_STRGR P45496, (246 aa) opt: 722, E(): 1.9e-37; (49.4% identity in 245 aa overlap) X2BJI0 No NC_002945.3 Mycobrowser_v2 CDS 2388899 2390038 . - 0 Mb2174c ftsZ cell division protein FtsZ Mb2174c, ftsZ, len: 379 aa. Equivalent to Rv2150c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). ftsZ, cell division protein (see first citation below). Contains FtsZ protein signature 2 (PS01135). FASTA best: FTSZ_STRCO P45500 cell division protein FtsZ (399 aa) opt: 1674, E(): 0; (77.3% identity in 339 aa overlap). X2BKA6,P64171 No NC_002945.3 Mycobrowser_v2 CDS 2562647 2563501 . - 0 Mb2340c HYPOTHETICAL PROTEIN Mb2340c, -, len: 284 aa. Equivalent to Rv2313c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Hypothetical unknown protein. X2BKS1 No conserved hypotheticals Rv2313c NC_002945.3 Mycobrowser_v2 CDS 2390211 2391155 . - 0 Mb2175c ftsQ POSSIBLE CELL DIVISION PROTEIN FTSQ Mb2175c, ftsQ, len: 314 aa. Equivalent to Rv2151c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Possible ftsQ, cell division protein, with some homology to FTSQ_STRGR|P45503 cell division protein ftsq homolog from Streptomyces griseus (208 aa), FASTA scores: opt: 204, E(): 4e-05; (30.6% identity in 193 aa overlap). X2BJV8,P64169 No NC_002945.3 Mycobrowser_v2 CDS 2391152 2392636 . - 0 Mb2176c murC probable udp-n-acetylmuramate-alanine ligase murc Mb2176c, murC, len: 494 aa. Equivalent to Rv2152c,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 494 aa overlap). Probable murC,UDP-N-acetylmuramate-alanine ligase (EC 6.3.2.8). FASTA best: MURC_ECOLI P17952 (491 aa) opt: 764, E(): 0; (36.9% identity in 474 aa overlap) X2BK24,P65473 No NC_002945.3 Mycobrowser_v2 CDS 2392633 2393865 . - 0 Mb2177c murG probable upd-n-acetylglucosamine-n-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-n-acetylglucosamine transferase murg Mb2177c, murG, len: 410 aa. Equivalent to Rv2153c,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 410 aa overlap). Probable MURG PROTEIN (UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase. FASTA score: MURG_BACSU P37585 murg protein (363 aa) opt: 494, E(): 1.1e-20; (27.9% identity in 365 aa overlap) X2BK91,Q7VEP8 No NC_002945.3 Mycobrowser_v2 CDS 2393862 2395436 . - 0 Mb2178c ftsW FtsW-like protein FtsW Mb2178c, ftsW, len: 524 aa. Equivalent to Rv2154c,len: 524 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 524 aa overlap). Probable ftsW, cell division protein, related to MTCY10H4.17c, 3.2e-17. FASTA best: SP5E_BACSU P07373 stage V sporulation protein E (366 aa) opt: 755, E(): 1.6e-33; (38.4% identity in 357 aa overlap) X2BJI2,P63763 No NC_002945.3 Mycobrowser_v2 CDS 2395448 2396908 . - 0 Mb2179c murD probable udp-n-acetylmuramoylalanine-d-glutamate ligase murd Mb2179c, -, len: 486 aa. Equivalent to Rv2155c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 486 aa overlap). Probable murD,UDP-N-acetylmuramoylalanine-D-glutamate ligase (EC 6.3.2.9). FASTA best: MURD_BACSU Q03522 (451 aa) opt: 534,E(): 2.7e-25; (28.8% identity in 483 aa overlap); contains PS01011 Folylpolyglutamate synthase signature 1 X2BKB2,Q7VEP7 No cell wall and cell processes Rv2155c NC_002945.3 Mycobrowser_v2 CDS 2396910 2397989 . - 0 Mb2180c murX probable phospho-n-acetylmuramoyl-pentappeptidetransferase murx Mb2180c, murX, len: 359 aa. Equivalent to Rv2156c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable murX,phospho-N-acetylmuramoyl-pentappeptidetransferase (EC 2.7.8 .13). FASTA best: MRAY_ECOLI P15876 (360 aa) opt: 572 z-sco re: 651.6 E(): 2.7e-29; (35.8% identity in 344 aa overlap) X2BJW5,P64260 No NC_002945.3 Mycobrowser_v2 CDS 2397986 2399518 . - 0 Mb2181c murF probable udp-n-acetylmuramoylalanyl-d-glutamyl-2,6-diaminopimelate-d-alanyl-d-alanyl ligase murf Mb2181c, murF, len: 510 aa. Equivalent to Rv2157c,len: 510 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 510 aa overlap). Probable murF,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D -alanyl-D-alanyl ligase (EC 6.3.2.15) (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE) also related to other Mycobacterium tuberculosis mur gene products. FASTA best: MURF_ECOLI P11880 (452 aa) opt: 515, E(): 2.6e-24, (31.9% identity in 511 aa overlap); deleted EC number 6.3.2.15 X2BK26,P0A5L5 No NC_002945.3 Mycobrowser_v2 CDS 2399515 2401122 . - 0 Mb2182c murE Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE Mb2182c, murE, len: 535 aa. Equivalent to Rv2158c,len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 535 aa overlap). Probable murE,UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (EC 6.3.2.13; UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE) also related to other Mycobacterium tuberculosis mur gene products. FASTA best: MURE_BACSU Q03523 (494 aa) opt: 1020 z- score: 1110.1 E(): 0; (40.1% identity in 476 aa overlap) X2BK97,P65478 No NC_002945.3 Mycobrowser_v2 CDS 2401145 2402179 . - 0 Mb2183c conserved protein Mb2183c, -, len: 344 aa. Equivalent to Rv2159c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein from Streptomyces coelicolor SC1A6.09c (337 aa,29% identity). Smith-Waterman scores: >pir||T28690 hypothetical protein - Streptomyces coelicolor >gi|3127841|emb|CAA18907.1| (AL023496) Expect = 2e-18 Q7TYZ4 No conserved hypotheticals Rv2159c NC_002945.3 Mycobrowser_v2 CDS 2407476 2408630 . - 0 Mb2188c PROBABLE CONSERVED PROLINE RICH MEMBRANE PROTEIN Mb2188c, -, len: 384 aa. Equivalent to Rv2164c,len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 384 aa overlap). Probable pro- rich conserved membrane protein, equivalent to ML0907|AL022602 putative conserved membrane protein from Mycobacterium leprae (377 aa) (AL022602), FASTA scores: opt: 1495, E(): 1.7e-56, (62.217% identity in 397 aa overlap). Q7TYZ1 No cell wall and cell processes Rv2164c NC_002945.3 Mycobrowser_v2 CDS 2402176 2402796 . - 0 Mb2184c CONSERVED HYPOTHETICAL PROTEIN Mb2184c, -, len: 206 aa. Similar to 5' end of Rv2160A and 3' end of Rv2160c, len: 211 aa and 112 aa,from Mycobacterium tuberculosis strain H37Rv, (96.3% identity in 107 aa overlap and 92.0% identity in 112 aa overlap). Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to N-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), FASTA scores: opt: 285, E(): 1.4e-08,(51.042% identity in 96 aa overlap). Next gene, Rv2160c,is similar to C-terminal half of 2SCK31.01c suggesting possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to C-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), while Rv2160A is similar to the N-terminal half of 2SCK31.01c. This suggests possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a 4 bp insertion (*-ggaa) leads to a single product. Q7TYZ3 No NC_002945.3 Mycobrowser_v2 CDS 2402789 2403655 . - 0 Mb2185c conserved protein Mb2185c, -, len: 288 aa. Equivalent to Rv2161c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap). Conserved hypothetical protein; shows some similarity to protein involved in lincomycin production and to other M. tuberculosis proteins e.g. Rv0953c, Rv0791c, Rv0132c,Rv2951c, Rv1855c. FASTA best: Q54379 (78-11) LINCOMYCIN PRODUCTION GENES (295 aa) opt: 243, E(): 2.4e-09; (29.5% identity in 285 aa overlap). Q7TYZ2 No intermediary metabolism and respiration Rv2161c NC_002945.3 Mycobrowser_v2 CDS 2403758 2405230 . - 0 Mb2186c PE_PGRS38 pe-pgrs family protein pe_pgrs38 Mb2186c, PE_PGRS38, len: 490 aa. Similar to Rv2162c, len: 532 aa, from Mycobacterium tuberculosis strain H37Rv, (92.105% identity in 532 aa overlap). Member of Mycobacterium tuberculosis PE_PGRS family. FASTA score: Y03A_MYCTU Q 10637 hypothetical glycine-rich 49.6 kd protein (603 aa) op t: 1798 z-score: 1220.0 E(): 0; (55.4% identity in 590 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa). Q7VEP6 No NC_002945.3 Mycobrowser_v2 CDS 2442380 2442799 . - 0 Mb2222c Possible conserved integral membrane protein Mb2222c, -, len: 139 aa. Equivalent to Rv2199c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Possible conserved integral membrane protein, similar to hypothetical membrane proteins in Actinomycetes and equivalent to Mycobacterium leprae, ML0876, putative membrane protein (139 aa) FASTA scores: opt: 866, E(): 1.1e-43; 91.367% identity in 139 aa overlap CAC31257.1| (AL583920) X2BKD3,P64948 No cell wall and cell processes Rv2199c NC_002945.3 Mycobrowser_v2 CDS 2405440 2407479 . - 0 Mb2187c pbpB Probable penicillin-binding membrane protein pbpB Mb2187c, pbpB, len: 679 aa. Equivalent to Rv2163c,len: 679 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 679 aa overlap). Probable pbpB,penicillin-binding membrane protein, similar to many bacterial PBP2 proteins e.g. P11882|PBP2_NEIME|PENA|NMA2072|NMB0413 penicillin-binding protein 2 (pbp-2) from Neisseria meningitidis (serogroups A and B) (581 aa), FASTA scores: opt: 665, E(): 1.6e-31,(33.2% identity in 591 aa overlap); etc. Also similar to Rv0016c and Rv2864c from Mycobacterium tuberculosis (2.8e-10). Contains PS00017 possible ATP/GTP-binding site motif A (P-loop) near C-terminus. FASTA best: PBP2_NEIME P11882 penicillin-binding protein 2 (pbp-2). (581 aa) opt: 665, E(): 1.6e-31; (33 .2% identity in 591 aa overlap) Q7VEP5 No NC_002945.3 Mycobrowser_v2 CDS 2408627 2409817 . - 0 Mb2189c conserved protein Mb2189c, -, len: 396 aa. Equivalent to Rv2165c,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Conserved hypothetical protein; shows strong similarity to several hypothetical bacterial proteins but has extra 80 aa residues at N-terminus FASTA best: YLXA_BACSU Q07876 hypothetical 35.3 kd protein in ftsl (311 aa) opt: 781,E(): 0; (45.6% identity in 296 aa overlap), BELONGS TO THE YABC (E.COLI), YLXA (B.SUBTILIS) FAMILY X2BKC0,P65430 No conserved hypotheticals Rv2165c NC_002945.3 Mycobrowser_v2 CDS 2409819 2410250 . - 0 Mb2190c conserved protein Mb2190c, -, len: 143 aa. Equivalent to Rv2166c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein; shows strong similarity to several hypothetical bacterial proteins such as YLLB_BACSU P55343. Is equivalent to Mycobacterium leprae hypothetical protein ML0905 (143 aa, 92% identity) MLCB268.11c >sp|O69561|YL66_MYCLE HYPOTHETICAL 16.1 KDA PROTEIN ML0905 >gi|3080482|emb|CAA18677.1|(AL022602) >gi|13092975|emb|CAC31286.1|(AL583920). FASTA scores: ML0905|ML0905 conserved hypothetical protein (143 aa) opt: 873, E(): 3.1e-52; 92.254% identity in 142 aa overlap; YLLB_BACSU P55343 hypothetical 16.6 kd protein (143 aa) opt: 340, E(): 3.6e-17; (35.0% identity in 143 aa overlap). BELONGS TO THE YABB (E.COLI), YLLB (B.SUBTILIS),MG221 ( M.GENITALIUM) FAMILY X2BJY0 No conserved hypotheticals Rv2166c NC_002945.3 Mycobrowser_v2 CDS 2410599 2411003 . - 0 Mb2191c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2191c, -, len: 134 aa. Equivalent to Rv2169c,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Probable conserved transmembrane protein, with orthologs in M. leprae, ML0904 probable membrane protein (134 aa), and Streptomyces coelicolor. FASTA scores with ML0904, opt: 767, E(): 5.1e-43; 86.567% identity in 134 aa overlap. emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1| (AL583920). TBparse score is 0.934 Q7TYZ0 No cell wall and cell processes Rv2169c NC_002945.3 Mycobrowser_v2 CDS 2420845 2421351 . - 0 Mb2201c CONSERVED HYPOTHETICAL PROTEIN Mb2201c, -, len: 168 aa. Equivalent to Rv2179c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Conserved hypothetical protein, equivalent to conserved hypothetical protein from Mycobacterium leprae ML0895 conserved hypothetical protein (171 aa). FASTA scores: opt: 977,E(): 1.4e-58; 82.530% identity in 166 aa overlap (AL022602). Q7TYY4 No conserved hypotheticals Rv2179c NC_002945.3 Mycobrowser_v2 CDS 2411269 2411889 . + 0 Mb2192 gcn5-related n-acetyltransferase Mb2192, -, len: 206 aa. Equivalent to Rv2170, len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Conserved hypothetical protein, equivalent to hypothetical protein ML0903 (210 aa) from Mycobacterium leprae. FASTA scores: ML0903 conserved hypothetical protein (210 aa) opt: 1045,E(): 9.1e-57; 77.143% identity in 210 aa overlap. >emb|CAA18679.1| (AL022602) >gi|13092973|emb|CAC31284.1| (AL583920). Q7TYY9 No intermediary metabolism and respiration Rv2170 NC_002945.3 Mycobrowser_v2 CDS 2411985 2412668 . + 0 Mb2193 lppM Probable conserved lipoprotein lppM Mb2193, lppM, len: 227 aa. Equivalent to Rv2171,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). Probable lppM,conserved lipoprotein; contains putative signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Has hydrophobic stretch at C-terminus and also contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. Unknown but equivalent to Mycobacterium leprae lipoprotein ML0902 (239 aa). FASTA scores: opt: 1083, E(): 2.4e-56; 75.446% identity in 224 aa overlap (5-227:16-239) >emb|CAA18680.1| (AL022602) >gi|13092972|emb|CAC31283.1| (AL583920). Q7VEP4 No cell wall and cell processes Rv2171 NC_002945.3 Mycobrowser_v2 CDS 2412665 2413570 . - 0 Mb2194c conserved protein Mb2194c, -, len: 301 aa. Equivalent to Rv2172c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae conserved hypothetical protein ML0901 (304 aa). FASTA scores: opt: 1656, E(): 7.7e-98; 81.271% identity in 299 aa overlap (1-299:1-299) CAA18681.1|AL022602|13092971|CAC31282.1|AL583920. TBparse score is 0.905 Q7TYY8 No conserved hypotheticals Rv2172c NC_002945.3 Mycobrowser_v2 CDS 2413881 2414939 . + 0 Mb2195 idsA2 PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE) Mb2195, idsA2, len: 352 aa. Equivalent to Rv2173,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Probable idsA2,geranylgeranyl pyrophosphate synthase (EC 2.5.1.-),similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Contains PS00723 and PS00444Polyprenyl synthetases signature 1 and 2. FASTA scores: sptr|Q54193|Q54193 GERANYLGERANYL PYROPHOSPHATE SYNTHASE (425 aa) opt: 744, E(): 0; 39.2% identity in 352 aa overlap. Q7TYY7 No NC_002945.3 Mycobrowser_v2 CDS 2422336 2423619 . + 0 Mb2203 alpha(1->2)mannosyltransferase Mb2203, -, len: 427 aa. Equivalent to Rv2181, len: 427 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 427 aa overlap). Probable conserved integral membrane protein, similar to others in Mycobacterium tuberculosis e.g. Rv1159 (MTCI65.26, 431 aa). Start uncertain. FASTA scores: Z95584|MTCI65_26 (431 aa) opt: 428, E(): 8e-22; 31.2% identity in 407 aa overlap. Q7VEN9 No cell wall and cell processes Rv2181 NC_002945.3 Mycobrowser_v2 CDS 2421361 2422248 . - 0 Mb2202c Probable conserved integral membrane protein Mb2202c, -, len: 295 aa. Equivalent to Rv2180c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable conserved integral membrane protein, similar to pir||T35292 probable integral membrane protein from Streptomyces coelicolor >gi|5578858|emb|CAB51260.1| (AL096872) (246 aa) (36% identity in 249 aa overlap). Q7VEP0 No cell wall and cell processes Rv2180c NC_002945.3 Mycobrowser_v2 CDS 2414943 2416493 . + 0 Mb2196 mpta alpha(1->6)mannosyltransferase. possible conserved integral membrane protein. Mb2196, -, len: 516 aa. Equivalent to Rv2174, len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 516 aa overlap). Possible conserved integral membrane protein, similar to some hypothetical mycobacterial proteins e.g. Mycobacterium leprae ML0899 probable integral-membrane protein (505 aa) and MLCL536_26 (593 aa). FASTA scores: ML0899 opt: 2715; 78.884% identity in 502 aa overlap and gp|Z99125|MLCL536_26 Mycobacterium leprae cosmid L536. (593 aa) opt: 552, E(): 7.1e-30; 31.6% identity in 513 aa overlap. Also similar to Rv1459c. Q7VEP3 No cell wall and cell processes Rv2174 NC_002945.3 Mycobrowser_v2 CDS 2416480 2416920 . - 0 Mb2197c conserved regulatory protein Mb2197c, -, len: 146 aa. Equivalent to Rv2175c,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Conserved hypothetical protein, possibly involved in regulation. Contains possible helix-turn-helix domain at aa 31-52 (Score 1042,+2.74 SD). Equivalent to Mycobacterium leprae ML0898 putative DNA-binding protein (134 aa). FASTA scores: opt: 747; 82.090% identity in 134 aa overlap (AL022602) >gi|13092969|emb|CAC31279.1| (AL583920) Q7VEP2 No regulatory proteins Rv2175c NC_002945.3 Mycobrowser_v2 CDS 2416975 2418174 . + 0 Mb2198 pknL PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L) Mb2198, pknL, len: 399 aa. Equivalent to Rv2176,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 399 aa overlap). Probable pknL,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to many e.g. MLCB1770_9 (622 aa). Lacks C-terminal domain and ends with putative transmembrane segment. Contains PS00108 Serine/Threonine protein kinases active-site signature. FASTA scores: Z70722|MLC B1770_9 Mycobacterium leprae cosmid B1770 (622 aa) opt: 732, E(): 5.9e-23; 44.4% identity in 266 aa overlap. Also similar to several Mycobacterium tuberculosis STPK proteins e.g. Rv0014c|PKNB,Rv0015c|PKNA, Rv1743|PKNE, Rv1266c|PKNH etc. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. X2BJJ4,Q7TYY6 No regulatory proteins Rv2176 NC_002945.3 Mycobrowser_v2 CDS 2418316 2418981 . - 0 Mb2199c POSSIBLE TRANSPOSASE Mb2199c, -, len: 221 aa. Equivalent to Rv2177c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 221 aa overlap). Possible IS1558 transposase (see citation below), similar to several IS element proteins and transposases but nearly identical to last 221 residues of MTCY428_23 (333 aa). FASTA scores: Z81451|MTCY428_23 Mycobacterium tuberculosis cosmid (333 aa) opt: 1491, E() : 0; 98.6% identity in 221 aa overlap. Q7TYY5 No insertion seqs and phages Rv2177c NC_002945.3 Mycobrowser_v2 CDS 2419366 2420754 . - 0 Mb2200c aroG 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase arog (dahp synthetase,phenylalanine-repressible) Mb2200c, aroG, len: 462 aa. Equivalent to Rv2178c,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 462 aa overlap). Probable aroG,3-deoxy-D-arabino-heptulosonate 7-phosphate synthase similar to many, especially those from plants. FASTA scores: Y15113|M C3DDAH7P_1Morinda citrifolia mRNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (535 aa) opt: 1421, E(): 0; 48.3% identity in 443 aa overlap. Q7VEP1 No NC_002945.3 Mycobrowser_v2 CDS 2423620 2424363 . - 0 Mb2204c 1-acylglycerol-3-phosphate O-acyltransferase Mb2204c, -, len: 247 aa. Equivalent to Rv2182c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Probable 1-acylglycerol-3-phosphate O-acyltransferase, similar to many e.g. in Streptomyces. Contains PS00017 ATP/GTP-binding site motif A (P-loop). FASTA scores: pir||T35503 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) homolog SC6E10.16c - Streptomyces coelicolor >gi|5689932|emb|CAB51970.1| (AL109661) hypothetical protein [Streptomyces coelicolor A3(2)] Length = 262,Expect = 6e-61 (54% identity in 215 aa overlap). Q7VEN8 No conserved hypotheticals Rv2182c NC_002945.3 Mycobrowser_v2 CDS 2424449 2424844 . - 0 Mb2205c conserved protein Mb2205c, -, len: 131 aa. Equivalent to Rv2183c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein ML0891 (MLCB268.25c, 130 aa). FASTA scores: opt: 558, E(): 8.3e-28; 61.832% identity in 131 aa overlap >gi|13092963|emb|CAC31272.1| (AL583920) (AL022602). Q7TYY3 No conserved hypotheticals Rv2183c NC_002945.3 Mycobrowser_v2 CDS 2424841 2425980 . - 0 Mb2206c CONSERVED HYPOTHETICAL PROTEIN Mb2206c, -, len: 379 aa. Equivalent to Rv2184c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Conserved hypothetical protein, equivalent to hypothetical protein ML0890 (415 aa) from Mycobacterium leprae and also shows some similarity to other hypothetical proteins. FASTA scores: ML0890 opt: 1949; 79.630% identity in 378 aa overlap >emb|CAA18692.1| (AL022602) >gi|13092962|emb|CAC31271.1| (AL583920) and sptr|Q55794|Q55794 HYPOTHETICAL 44.6 KD PROTEIN. (396 aa) opt: 251, E(): 3.3e-09; 25.5% identity in 384 aa overlap. Q7TYY2 No conserved hypotheticals Rv2184c NC_002945.3 Mycobrowser_v2 CDS 2426100 2426534 . - 0 Mb2207c TB16.3 conserved protein tb16.3 Mb2207c, TB16.3, len: 144 aa. Equivalent to Rv2185c, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 144 aa overlap). TB16.3,conserved hypothetical protein, similar to other hypothetical actinomycete proteins and equivalent to Mycobacterium leprae ML0889 (144 aa). Some similarity to Mycobacterium tuberculosis Rv0854, Rv0856, Rv0857, Rv0164 and other Mycobacterium leprae proteins. FASTA scores : ML0889 opt: 811; 85.417% identity in 144 aa overlap (AL022602). Q7TYY1 No conserved hypotheticals Rv2185c NC_002945.3 Mycobrowser_v2 CDS 2427194 2427706 . + 0 Mb2209 fadd15 HYPOTHETICAL PROTEIN Mb2209, -, len: 170 aa. Equivalent to 5' end of Rv2187, len: 600 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Probable fadD15, long-chain-fatty-acid-CoA ligase (EC 6.2.1.3),similar to several e.g. P44446|LCFH_HAEIN PUTATIVE LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): 0, (31.5% identity in 578 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts, Mb2209 and fadD15. Q7TYX9 No NC_002945.3 Mycobrowser_v2 CDS 2427469 2428995 . + 0 Mb2210 fadD15 Probable long-chain-fatty-acid-CoA ligase fadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Mb2210, fadD15, len: 508 aa. Equivalent to 3' end of Rv2187, len: 600 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 508 aa overlap). Probable fadD15, long-chain-fatty-acid-CoA ligase (EC 6.2.1.3),similar to several e.g. P44446|LCFH_HAEIN PUTATIVE LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): 0, (31.5% identity in 578 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. TBparse score is 0.902. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to single base deletion (t-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. X2BK09,Q7TYX8 No NC_002945.3 Mycobrowser_v2 CDS 2437425 2438714 . + 0 Mb2218 qcrA Probable Rieske iron-sulfur protein QcrA Mb2218, qcrA, len: 429 aa. Equivalent to Rv2195,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 429 aa overlap). Probable qcrA,Ubiquinol-cytochrome C reductase iron-sulfur subunit (cyoB), shows some similarity to cytochrome B6-F complex iron-sulphur subunits (Rieske iron-sulfur protein); contains PS00200 Rieske iron-sulfur protein signature 2 X2BJK9,Q7TYX4 No intermediary metabolism and respiration Rv2195 NC_002945.3 Mycobrowser_v2 CDS 2429026 2430183 . - 0 Mb2211c pimb mannosyltransferase pimb Mb2211c, -, len: 385 aa. Equivalent to Rv2188c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Conserved hypothetical protein, possibly glycosyl transferase similar to several putative glycosyl transferases and hypothetical proteins e.g. P73369. Equivalent to Mycobacterium leprae ML0886 putative glycosyl transferase (384 aa). FASTA scores: ML0886 (CAA18697.1| (AL022602) ) opt: 2113, E(): 1.8e-106; 81.462% identity in 383 aa overlap; sptr|P73369|P73369 HYPOTHETICAL 46.2 KD PROTEIN (404 aa) opt: 379, E(): 2.2e-18; 27.5% identity in 397 aa overlap. Start changed since first submission, now 14 aa shorter. Q7TYX7 No lipid metabolism Rv2188c NC_002945.3 Mycobrowser_v2 CDS 2430280 2431053 . - 0 Mb2212c CONSERVED HYPOTHETICAL PROTEIN Mb2212c, -, len: 257 aa. Equivalent to Rv2189c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein SC6G10.07c (385 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores: pir||T35516 hypothetical protein SC6G10.07c - Streptomyces coelicolor >gi|4539203|emb|CAB39861.1| (AL049497) Expect = 2e-08; 30% identity in 245 aa overlap. TBparse score is 0.908 Q7TYX6 No conserved hypotheticals Rv2189c NC_002945.3 Mycobrowser_v2 CDS 2436586 2437428 . + 0 Mb2217 qcrC Probable Ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) Mb2217, qcrC, len: 280 aa. Equivalent to Rv2194,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable qcrC,Ubiquinol-cytochrome C reductase cytochrome C subunit (cyoA), shows similarity to cytochrome c family; contains 2 X PS00190 Cytochrome c family heme-binding site signature. X2BKD0,P63888 No intermediary metabolism and respiration Rv2194 NC_002945.3 Mycobrowser_v2 CDS 2431148 2432305 . - 0 Mb2213c CONSERVED HYPOTHETICAL PROTEIN Mb2213c, -, len: 385 aa. Equivalent to Rv2190c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477, Rv1478, Rv1566c,Rv0024, that are similar to protein p60 precursors from Listeria eg Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 a a) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE PROTEIN P60 PRECURSOR (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap. X2BJK7,P67474 No virulence, detoxification, adaptation Rv2190c NC_002945.3 Mycobrowser_v2 CDS 2442807 2443898 . - 0 Mb2223c ctaC PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC Mb2223c, ctaC, len: 363 aa. Equivalent to Rv2200c,len: 363 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 363 aa overlap). Probable ctaC,transmembrane cytochrome C oxidase (subunit II), COX2,similar e.g. to JT0964 cytochrome-c oxidase chain II (23.0% identity in 317 aa overlap); etc. Contains PS00078 Cytochrome c oxidase subunit II, copper A binding region signature. BELONGS TO THE CYTOCHROME C OXIDASE SUBUNIT 2 FAMILY. X2BJL3,P63855 No NC_002945.3 Mycobrowser_v2 CDS 2432852 2434789 . + 0 Mb2214 CONSERVED HYPOTHETICAL PROTEIN Mb2214, -, len: 645 aa. Equivalent to Rv2191, len: 645 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 645 aa overlap). Conserved hypothetical protein, similar to SW:DP3A_B ACSU P13267 DNA polymerase III, alpha chain (31.3% identity in 249 aa overlap) and SW:UVRC_ECOLI P07028 excinuclease ABC subunit C (25.7% identity in 230 aa overlap). Also similar to M. tuberculosis Rv3711c (dnaQ DNA polymerase III e chain) and Rv1420 (uvrC excinuclease ABC subunit C) Q7TYX5 No information pathways Rv2191 NC_002945.3 Mycobrowser_v2 CDS 2434664 2435776 . - 0 Mb2215c trpD Probable anthranilate phosphoribosyltransferase TrpD Mb2215c, trpD, len: 370 aa. Equivalent to Rv2192c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 370 aa overlap). Probable trpD,anthranilate phosphoribosyltransferase (EC 2.4.2.18) (see citation below), similar to e.g. TRPD_LACCA|P17170, (43.2% identity in 308 aa overlap). Initiation codon uncertain,gtg at 4086 in MTCY190 favoured by homology but this has no clear ribosome binding site. X2BK14,P66993 No NC_002945.3 Mycobrowser_v2 CDS 2435934 2436545 . + 0 Mb2216 ctaE PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE Mb2216, ctaE, len: 203 aa. Equivalent to Rv2193,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Probable ctaE,cytochrome c oxidase polypeptide III (cox3) (EC 1.9.3.1),with strong similarity to others e.g. COX3_SYNY3|Q06475 (29.8% identity in 225 aa overlap). X2BK43,P63857 No intermediary metabolism and respiration Rv2193 NC_002945.3 Mycobrowser_v2 CDS 2448078 2448434 . - 0 Mb2227c conserved protein Mb2227c, -, len: 118 aa. Equivalent to Rv2204c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein. Similar to conserved hypothetical proteins in Actinomycetes and equivalent to Mycobacterium leprae ML0871|ML0871 conserved hypothetical protein (118 aa) and to sp|P45344|YADR_HAEIN HYPOTHETICAL PROTEIN HI1723 (114 aa). FASTA score: ML0871 opt: 720, E(): 8.4e-45; 92.373% identity in 118 aa overlapCAC31252.1| (AL583920); and P45344 opt: 346, E(): 1.8e-18; 45.6% identity in 103 aa overlap. Contains PS01152 Hypothetical hesB/y yadR/yfhF family signature X2BKD8,P0A5B0 No conserved hypotheticals Rv2204c NC_002945.3 Mycobrowser_v2 CDS 2438711 2440360 . + 0 Mb2219 qcrB Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) Mb2219, qcrB, len: 549 aa. Equivalent to Rv2196,len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 549 aa overlap). Probable qcrB,Ubiquinol-cytochrome C reductase cytochrome B subunit (cytB), integral membrane protein, low similarity in amino-terminal half to cytochrome b subunits, highly similar at C-terminus to SW:12KD_MYCLE P15878 12 KD protein PIR:S08427 (86.9% identity in 153 aa overlap). FASTA scores: sp|Q45658|QCRB_BACST MENAQUINOL-CYTOCHROME C REDUCTASE (224 aa) opt: 341, E(): 6.8e-15; 28.0% identity in 207 aa overlap X2BKE6,P63886 No intermediary metabolism and respiration Rv2196 NC_002945.3 Mycobrowser_v2 CDS 2440651 2441295 . - 0 Mb2220c Probable conserved transmembrane protein Mb2220c, -, len: 214 aa. Equivalent to Rv2197c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 214 aa overlap). Probable conserved transmembrane protein, equivalent to ML0878 conserved hypothetical protein (212 aa) of Mycobacterium leprae. FASTA scores: opt: 858; 62.559% identity in 211 aa overlap CAC31259.1|(AL583920) Q7VEN7 No cell wall and cell processes Rv2197c NC_002945.3 Mycobrowser_v2 CDS 2441295 2442194 . - 0 Mb2221c mmpS3 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS3 Mb2221c, mmpS3, len: 299 aa. Equivalent to Rv2198c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Probable mmpS3,conserved membrane protein (see citation below),equivalent to ML0877|mmpS3 putative membrane protein from Mycobacterium leprae (293 aa), FASTA scores: opt: 1089,E(): 1.2e-43, (69.80% identity in 308 aa overlap). Also similar to other proteins e.g. Rv3209 from Mycobacterium tuberculosis. Contains PS00499 C2 domain signature, a hydrophobic region, and a repetitive proline and threonine rich region. BELONGS TO THE MMPS FAMILY. X2BK45,P65379 No NC_002945.3 Mycobrowser_v2 CDS 2444144 2446102 . + 0 Mb2224 asnB Probable asparagine synthetase AsnB Mb2224, asnB, len: 652 aa. Equivalent to Rv2201,len: 652 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 652 aa overlap). Probable asnB,asparagine synthetase, similar to e.g. SW:ASNH_BACSU P42113 putative asparagine synthetase (26.0% identity in 438 aa overlap) X2BKF1,P64248 No intermediary metabolism and respiration Rv2201 NC_002945.3 Mycobrowser_v2 CDS 2446200 2447174 . - 0 Mb2225c adok adenosine kinase Mb2225c, cbhK, len: 324 aa. Equivalent to Rv2202c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Probable cbhK,carbohydrate kinase (but not ribose) (EC 2.7.-.-), similar to several e.g. AE000915_1 Methanobacterium thermoautotrop (309 aa) FASTA score: opt: 370, E(): 3.3e-18; 31.2% identity in 276 aa overlap. Low similarity to carbohydrate kinases, e.g. SW:RBSK_BACSU P36945 ribokinase (23.9% identity in 272 aa overlap); contains PS00583 pfkB family of carbohydrate kinases signature 1 X2BK30,P83736 No NC_002945.3 Mycobrowser_v2 CDS 2447378 2448070 . + 0 Mb2226 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb2226, -, len: 230 aa. Equivalent to Rv2203, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Possible conserved membrane protein; has single hydrophobic stretch from aa 75 to 97 and is equivalent to Mycobacterium leprae ML0872 putative membrane protein (171 aa). FASTA scores: opt: 821, E(): 3.4e-42; 72.353% identity in 170 aa overlap -CAC31253.1| (AL583920). 2468411. X2BK48,P64950 No cell wall and cell processes Rv2203 NC_002945.3 Mycobrowser_v2 CDS 2448534 2449610 . - 0 Mb2228c CONSERVED HYPOTHETICAL PROTEIN Mb2228c, -, len: 358 aa. Equivalent to Rv2205c,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Conserved hypothetical protein. Very similar to YHAD_ECOLI|P23524 hypothetical protein (YHAD (E.coli) / YXAA (S14A) (B.subtilis) family) (41.6% identity in 154 aa overlap),and to other members of the glycerate kinase family. Start changed since first submission; protein now 122 aa shorter, owing to extension of Rv2206. X2BJL5,P64289 No conserved hypotheticals Rv2205c NC_002945.3 Mycobrowser_v2 CDS 2449769 2450479 . + 0 Mb2229 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2229, -, len: 236 aa. Equivalent to Rv2206, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Probable conserved transmembrane protein. Equivalent to hypothetical protein ML0869 (247 aa) of Mycobacterium leprae gZ98741|MLCB22_2 (247 aa), FASTA scores: opt: 1052, (67.5% identity in 237 aa overlap). Two hydrophobic stretches in C-terminal part. Start changed since original submission (+112 aa). X2BKF6,P64952 No cell wall and cell processes Rv2206 NC_002945.3 Mycobrowser_v2 CDS 4032007 4032261 . - 0 Mb3678c CONSERVED HYPOTHETICAL PROTEIN Mb3678c, -, len: 84 aa. Equivalent to Rv3654c, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Hypothetical protein,similar to C-terminus of Q9X916|SCH5.14c MEMBRANE SPANNING PROTEIN from Streptomyces coelicolor (230 aa) FASTA scores: opt: 176, E(): 2.4e-05, (47.0% identity in 83 aa overlap). Equivalent to AAK48118 from Mycobacterium tuberculosis strain CDC1551 but shorter 18 aa. Q7TW09 No conserved hypotheticals Rv3654c NC_002945.3 Mycobrowser_v2 CDS 4033485 4034285 . - 0 Mb3682c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3682c, -, len: 266 aa. Equivalent to Rv3658c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable conserved transmembrane protein, similar to Q9X920|SCH5.18c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (321 aa), FASTA scores: opt: 335, E(): 4.1e-13, (38.05% identity in 247 aa overlap). Q7TW05 No cell wall and cell processes Rv3658c NC_002945.3 Mycobrowser_v2 CDS 2450558 2451643 . + 0 Mb2230 cobT Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT Mb2230, cobT, len: 361 aa. Equivalent to Rv2207,len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 361 aa overlap). Probable cobT,phosphoribosyltransferase, similar to many e.g. SW:COBT_ECOLI P36562 nicotinate-nucleotide--dimethylbenzimidazol phosphoribosyltransferase (34.6% identity in 341 aa overlap) X2BK38,P63842 No intermediary metabolism and respiration Rv2207 NC_002945.3 Mycobrowser_v2 CDS 2451640 2452389 . + 0 Mb2231 cobS Probable cobalamin 5'-phosphate synthase CobS Mb2231, cobS, len: 249 aa. Equivalent to Rv2208,len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 249 aa overlap). Probable cobS,cobalamin 5'-phosphate synthase; similarity to SW:COBS_ECOLI P36561 cobalamin (5'-phosphate) synthase (28.0% identity in 243 aa overlap) X2BK50,Q7VEN6 No intermediary metabolism and respiration Rv2208 NC_002945.3 Mycobrowser_v2 CDS 2452547 2454085 . + 0 Mb2232 Probable conserved integral membrane protein Mb2232, -, len: 512 aa. Equivalent to Rv2209, len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Probable conserved integral membrane protein, similar to but longer than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis (436 aa). FASTA score: opt: 712, E(): 2.8e-32; 33.4% identity in 422 aa overlap X2BKE5,P64954 No cell wall and cell processes Rv2209 NC_002945.3 Mycobrowser_v2 CDS 2454011 2455117 . - 0 Mb2233c ilvE branched-chain amino acid transaminase ilve Mb2233c, ilvE, len: 368 aa. Equivalent to Rv2210c,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 368 aa overlap). Probable ilvE,Branched-chain-amino-acid transaminase, highly similar to many e.g. YWAA_BACSU|P39576 from Bacillus subtilis (48.4% identity in 339 aa overlap); etc. Q7TYX3 No NC_002945.3 Mycobrowser_v2 CDS 2455189 2456328 . - 0 Mb2234c gcvT Probable aminomethyltransferase GcvT (Glycine cleavage system T protein) Mb2234c, gcvT, len: 379 aa. Equivalent to Rv2211c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Probable gcvT,aminomethyltransferase (EC 2.1.2.10), similar to many e.g. GCST_ECOLI|P27248 for Escherichia coli (38.2% identity in 364 aa overlap); etc. BELONGS TO THE GCVT FAMILY. X2BKG2,P64221 No NC_002945.3 Mycobrowser_v2 CDS 2456337 2457473 . + 0 Mb2235 adenylyl cyclase (atp pyrophosphate-lyase) (adenylate cyclase) Mb2235, -, len: 378 aa. Equivalent to Rv2212, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). Conserved hypothetical protein. Some similarity to adenylate cyclases, e.g. SW:CYAA_STRCO P40135 (29.2% identity in 291 aa overlap); ttg at 24614 in MTCY190 has a better rbs. Contains possible helix-turn-helix motif at aa 64-85,(+2.72 SD). Also similar to Rv1264 and Rv1647 X2BK46,P64266 No intermediary metabolism and respiration Rv2212 NC_002945.3 Mycobrowser_v2 CDS 2457485 2459032 . + 0 Mb2236 pepB Probable aminopeptidase PepB Mb2236, pepB, len: 515 aa. Equivalent to Rv2213,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). Probable pepB, leucine aminopeptidase, similar to many e.g. SW:AMPA_ECOLI P11648 aminopeptidase A/I, (41.4% identity in 309 aa overlap). Equivalent to Z98741|MLCB22_6 Mycobacterium leprae cosmid B22; Am (524 aa), FASTA scores: opt: 2793, E(): 0; 83.1% identity in 522 aa overlap. Contains PS00631 Cytosol aminopeptidase signature, NTDAEGRL X2BK52,Q7VEN5 No intermediary metabolism and respiration Rv2213 NC_002945.3 Mycobrowser_v2 CDS 2459070 2460848 . - 0 Mb2237c ephD Possible short-chain dehydrogenase EphD Mb2237c, ephD, len: 592 aa. Equivalent to Rv2214c,len: 592 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 592 aa overlap). Possible ephD,short-chain dehydrogenase (EC 1.-.-.-) (see citation below), equivalent to Z98741|MLCB22_8 Mycobacterium leprae cosmid B22; (596 aa), FASTA score: opt: 3262, E(): 0; 80.4% identity in 596 aa overlap. C-terminus similar to short-chain alcohol dehydrogenase family, similar to SW:LIGD_PSEPA Q01198 c alpha-dehydrogenase (30.7% identity in 241 aa overlap); contains PS00061 Short-chain alcohol dehydrogenase family signature, PS00697 ATP-dependent DNA ligase AMP-binding site. N-terminus corresponds to several epoxide hydrolases of plants and Mycobacterium tuberculosis e.g. MTCY9F925 X2BKF0,P66778 No NC_002945.3 Mycobrowser_v2 CDS 2461112 2462773 . + 0 Mb2238 dlat dlat, dihydrolipoamide acyltransferase, e2 component of pyruvate dehydrogenase Mb2238, sucB, len: 553 aa. Equivalent to Rv2215,len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 553 aa overlap). Probable sucB,dihydrolipoamide acetyltransferase component (E2), similar to e.g. SW:O PD2_ACHLA P35489 dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex (35.3% identity in 552 aa overlap); contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. X2BJM2,P65634 No intermediary metabolism and respiration Rv2215 NC_002945.3 Mycobrowser_v2 CDS 2462773 2463678 . + 0 Mb2239 conserved protein Mb2239, -, len: 301 aa. Equivalent to Rv2216, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae ML0860 (307 aa), Z98741|MLCB22_10 Mycobacterium leprae cosmid B22; H (307 aa). FASTA score: opt: 1656, E(): 0; 84.2% identity in 297 aa overlap. Also gp|AE000319|ECAE000319_8 Escherichia coli strain K12 MG1655 (297 aa) opt: 640, E(): 0; 39.5% identity in 294 aa overlap. X2BKG8,P67233 No conserved hypotheticals Rv2216 NC_002945.3 Mycobrowser_v2 CDS 2463731 2464423 . + 0 Mb2240 lipB Probable lipoate biosynthesis protein B LipB Mb2240, lipB, len: 230 aa. Equivalent to Rv2217,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 230 aa overlap). Probable lipB, similar to SW:LIPB_ECOLI P30976 liopate biosynthesis protein B ( 33.8% identity in 160 aa overlap). Equivalent to gp|Z98741| MLCB22_11 Mycobacterium leprae (235 aa). FASTA score: opt: 1124, E(): 0; 78.4% identity in 218 aa overlap X2BK54,Q7VEN4 No intermediary metabolism and respiration Rv2217 NC_002945.3 Mycobrowser_v2 CDS 2464420 2465355 . + 0 Mb2241 lipA Probable lipoate biosynthesis protein A LipA Mb2241, lipA, len: 311 aa. Equivalent to Rv2218,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Probable lipA, lipoic acid synthetase, similar to e.g. SW:LIPA_HAEIN P44463 (42 .6% identity in 291 aa overlap). Equivalent to Z98741|MLCB2 2_12 Mycobacterium leprae cosmid B22; (314 aa). FASTA score : opt: 1836, E(): 0; 86.8% identity in 310 aa overlap X2BK56,P65284 No intermediary metabolism and respiration Rv2218 NC_002945.3 Mycobrowser_v2 CDS 2465382 2466134 . + 0 Mb2242 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2242, -, len: 250 aa. Equivalent to Rv2219, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Probable conserved transmembrane protein. Equivalent to hypothetical membrane protein ML0857 (250 aa) from Mycobacterium leprae Z98741 |MLCB22_13 Mycobacterium leprae cosmid B22; H (250 aa) opt : 1328, E(): 0; 80.8% identity in 250 aa overlap. Q7TYX2 No cell wall and cell processes Rv2219 NC_002945.3 Mycobrowser_v2 CDS 2466762 2468198 . + 0 Mb2244 glnA1 GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (GS-I) Mb2244, glnA1, len: 478 aa. Equivalent to Rv2220,len: 478 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 478 aa overlap). glnA1, glutamine synthetase class I (EC 6.3.1.2) (see first citation below), similar to many e.g. GLNA_STRCO|P15106 from Streptomyces coelicolor, FASTA score: (71.4% identity in 475 aa overlap); etc. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2222c|glnA2, Rv2860c|glnA4, and Rv1878|glnA3. Contains PS00180 Glutamine synthetase signature 1, PS00181 Glutamine synthetase putative ATP-binding region signature, and PS00182 Glutamine synthetase class-I adenylation site. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY. X2BKH2,P0A591 No NC_002945.3 Mycobrowser_v2 CDS 2468516 2471500 . - 0 Mb2245c glnE GLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE (Glutamine-synthetase adenylyltransferase) Mb2245c, glnE, len: 994 aa. Equivalent to Rv2221c,len: 994 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 994 aa overlap). glnE,glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) (see citations below), similar to others e.g. GLNE_ECOLI|P30870 glutamate-ammonia-ligase adenylyltransferase from Escherichia coli, FASTA score: (24.4% identity in 721 aa overlap); GLNE_HAEIN|P44419 Glutamate-ammonia-ligase adenylyltransferase from Haemophilus influenzae (981 aa), FASTA score: (28.1% identity in 199 aa overlap); etc. Note that initiation codon uncertain. X2BK61,P69941 No NC_002945.3 Mycobrowser_v2 CDS 2471549 2472889 . - 0 Mb2246c glnA2 PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) Mb2246c, glnA2, len: 446 aa. Equivalent to Rv2222c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 446 aa overlap). Probable glnA2,glutamine synthetase class II (EC 6.3.1.2), similar to others. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2220|glnA1,Rv2860c|glnA4, and Rv1878|glnA3. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY. X2BK57,P64246 No NC_002945.3 Mycobrowser_v2 CDS 2897527 2897814 . + 0 Mb2633 vapb41 possible antitoxin vapb41 Mb2633, -, len: 95 aa. Equivalent to Rv2601A, len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 95 aa overlap). Q7TY94 No virulence, detoxification, adaptation Rv2601A NC_002945.3 Mycobrowser_v2 CDS 2487582 2488523 . - 0 Mb2260c cobD probable cobalamin biosynthesis transmembrane protein cobd Mb2260c, cobD, len: 313 aa. Equivalent to Rv2236c,len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 313 aa overlap). Probable cobD,conserved membrane protein, similar to PIR:S52223 Rhodobacter capsulatus 945 protein BluD (39.0% identity in 287 aa overlap) involved in cobinamide synthesis, and to SW:COBD_PSEDE Pseudomonas dentrificans cobD protein (37.5% identity in 269 aa overlap), also SW:CBIB_SALTY Salmonella typhimurum cbiB protein (35.5% identity in 304 aa overlap) X2BKH6,Q7VEN1 No NC_002945.3 Mycobrowser_v2 CDS 2472984 2474546 . - 0 Mb2247c Probable exported protease Mb2247c, -, len: 520 aa. Equivalent to Rv2223c,len: 520 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 520 aa overlap). Probable exported protease (EC 3.4.-.-); has signal sequence. Very similar to three proteases/peptidases from Streptomyces spp.: L42758, L42759, L27466. FASTA score: L42758|STMSLPD STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% identity in 533 aa overlap). Also similar to hypothetical proteins SW:YZZE _ECOLI P34211 (25.4% identity in 406 aa overlap) and PIR:B36944 in ompP 3' region (27.5% identity in 218 aa overlap). Highly similar to Rv2224c and Rv2672 (49.3% identity in 507 aa overlap); contains PS00120 Lipases, serine active site X2BKG1,P65822 No cell wall and cell processes Rv2223c NC_002945.3 Mycobrowser_v2 CDS 2474608 2476170 . - 0 Mb2248c caea probable carboxylesterase caea Mb2248c, -, len: 520 aa. Equivalent to Rv2224c,len: 520 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 520 aa overlap). Probable exported protease (EC 3.4.-.-); has signal sequence and lipoprotein motif at N-terminal end. Very similar to three proteases/peptidases from Streptomyces spp.: L42758,L42759, L27466. FASTA score: L4 2758|STMSLPD STMSLPD NID: g940302 -Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% identity in 533 aa overlap). Similar to hypothetical protein SW:YZZE_ECOLI P34211 (27.7% identity in 412 aa overlap) and highly similar to Rv2224c and Rv2672 (49.3% identity in 507 aa overlap); contains PS00013, Prokaryotic membrane lipoprotein lipid attachment site, and PS00120 Lipases, serine active site. X2BJM9,P65824 No cell wall and cell processes Rv2224c NC_002945.3 Mycobrowser_v2 CDS 2476889 2477734 . + 0 Mb2249 panB 3-methyl-2-oxobutanoate hydroxymethyltransferase panb Mb2249, panB, len: 281 aa. Equivalent to Rv2225,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Probable panB,3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11), similar to PANB_ECOLI|P31057 3-methyl-2-oxobutanoate hydroxymethyltransferase from Escherichia coli (45.9% identity in 257 aa overlap). X2BKH7,P0C2T4 No intermediary metabolism and respiration Rv2225 NC_002945.3 Mycobrowser_v2 CDS 2477979 2479520 . + 0 Mb2250 conserved protein Mb2250, -, len: 513 aa. Equivalent to Rv2226, len: 513 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 513 aa overlap). Conserved hypothetical protein, similar to hypothetical secreted protein (510 aa) from Streptomyces coelicolor A3(2) emb|CAB59601.1| (AL132662) hypothetical secreted protein [Streptomyces coelicolor. Smith-Waterman scores Expect = 5e-44 Identities = 166/506 (32%) Q7TYX0 No conserved hypotheticals Rv2226 NC_002945.3 Mycobrowser_v2 misc_RNA 2479592 2479898 . - 0 rnpB rnpB ribonuclease P RNA rnpB, len: 307 nt. Equivalent to rnpB, len: 307 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 307 nt overlap). rna component of RNase P. No NC_002945.3 Mycobrowser_v2 CDS 2480078 2480398 . + 0 Mb2251 conserved hypothetical protein [FIRST PART] Mb2251, -, len: 106 aa. Equivalent to 5' end of Rv2227, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv, (93.8% identity in 80 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins from various bacteria e.g. gb|AAK22693.1| (AE005746) conserved hypothetical protein from Caulobacter crescentus (234 aa) Smith-Waterman score = 109 bits (429),Expect = 1e-41 Identities = 83/167 (49%). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts, Mb2251 and Mb2252. Q7VEN3 No NC_002945.3 Mycobrowser_v2 CDS 2480406 2480780 . + 0 Mb2252 conserved hypothetical protein [SECOND PART] Mb2252, -, len: 124 aa. Equivalent to 3' end of Rv2227, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 124 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins from various bacteria e.g. gb|AAK22693.1| (AE005746) conserved hypothetical protein from Caulobacter crescentus (234 aa) Smith-Waterman score = 109 bits (429), Expect = 1e-41 Identities = 83/167 (49%). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts, Mb2251 and Mb2252. Q7VEN2 No NC_002945.3 Mycobrowser_v2 CDS 2488637 2489404 . + 0 Mb2261 conserved protein Mb2261, -, len: 255 aa. Equivalent to Rv2237, len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical proteins Rv0276, Rv0826,Rv1645c. FASTA score: Rv0276 gp|AL021930|MTV035_4 (306 aa) opt: 874, E(): 0; 49.6% identity in 282 aa overlap X2BJN9,P64958 No conserved hypotheticals Rv2237 NC_002945.3 Mycobrowser_v2 CDS 2480792 2481886 . - 0 Mb2253c multifunctional protein. has rnase h,alpha-ribazole phosphatase, and acid phosphatase activities. Mb2253c, -, len: 364 aa. Equivalent to Rv2228c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Conserved hypothetical protein. Some similarity to phosphoglycerate mutase and ribonuclease H. Similar to CAB88177.1|AL352972 putative bifunctional protein (ribonuclease H/phosphoglycerate mutase) from Streptomyces coelicolor A3(2) (497 aa); Smith-Waterman scores: 107 bits (424),Expect = 4e-41 Identities = 160/485 (32%). Also similar in C-terminal part to Rv2419c and Rv2135c. X2BJN1,P64956 No information pathways Rv2228c NC_002945.3 Mycobrowser_v2 CDS 2481883 2482620 . - 0 Mb2254c conserved protein Mb2254c, -, len: 245 aa. Equivalent to Rv2229c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 245 aa overlap). Conserved hypothetical protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922) Q7TYW9 No conserved hypotheticals Rv2229c NC_002945.3 Mycobrowser_v2 CDS 2482617 2483756 . - 0 Mb2255c conserved protein Mb2255c, -, len: 379 aa. Equivalent to Rv2230c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Conserved hypothetical protein. Equivalent to Mycobacterium leprae,ML1639, conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU HYPOTHETICAL 30. 7 KD PROTEIN IN (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P53434|YRP2_LISMO HYPOTHETICAL 41.4 KD PROTEIN (373 aa) opt: 595, E(): 1e-29; 30.7% identity in 326 aa overlap X2BK75,P0A657 No conserved hypotheticals Rv2230c NC_002945.3 Mycobrowser_v2 CDS 2483753 2484847 . - 0 Mb2256c cobC Possible aminotransferase CobC Mb2256c, cobC, len: 364 aa. Equivalent to Rv2231c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Possible cobC,aminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC PROTEIN (333 aa) opt: 277, E(): 1.7e-11; 28.8% identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase (27.0% identity in 289 aa overlap), contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site. Real Mycobacterium tuberculosis histidinol-phosphate aminotransferase, hisC, is Rv1600 (MTCY336.04c). X2BK63,P63501 No NC_002945.3 Mycobrowser_v2 CDS 2485426 2486301 . + 0 Mb2257 ptka protein tyrosine kinase transcriptional regulatory protein ptka Mb2257, -, len: 291 aa. Equivalent to Rv2232, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Conserved hypothetical protein, similar to members of haloacid dehalogenase-like family from several bacteria and to putative phosphatases e.g. Q9I767 and AAK78398. Contains N-terminal extension. FASTA scores: Q9I767 HYPOTHETICAL PROTEIN PA0065 (221 aa) opt: 439 E(): 3.2e-18; 38.679% identity (40.196% ungapped) in 212 aa overlap; >>tr|AAK78398 Predicted phosphatase, HAD family (216 aa) opt: 427, E(): 1.5e-17; 34.762% identity (35.437% ungapped) in 210 aa overlap. Replaces previous Rv2232 and Rv2233. X2BKI8 No regulatory proteins Rv2232 NC_002945.3 Mycobrowser_v2 CDS 2486294 2486785 . + 0 Mb2258 ptpA PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPA (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) (LMW PHOSPHATASE) Mb2258, ptpA, len: 163 aa. Equivalent to Rv2234,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). ptpA (alternate gene name: MPtpA), low molecular weight protein-tyrosine-phosphatase (see citations below) (EC 3.1.3.48), similar to other phosphotyrosine protein phosphatases e.g. P53433|PTPA_STRCO LOW MOLECULAR WEIGHT PROTEIN-TYROSINE PHOSPHATASE from Streptomyces coelicolor (164 aa), FASTA scores: opt: 455, E(): 3.3e -25, (49.7% identity in 155 aa overlap); PA1S_HUMAN|P24667 red cell acid phosphatase 1, FASTA score: (37.7% identity in 138 aa overlap); etc. Contains a phosphatase catalytic site domain located in N-terminal part. Activity proven biochemically. Supposed a secreted protein. X2BK81,P65717 No regulatory proteins Rv2234 NC_002945.3 Mycobrowser_v2 CDS 2486785 2487600 . + 0 Mb2259 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2259, -, len: 271 aa. Equivalent to Rv2235, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 271 aa overlap). Probable conserved transmembrane protein (see first citation below); hydrophobic regions near N- and C-terminus. Similar to conserved membrane proteins in other Actinomycetes. Equivalent to Mycobacterium leprae. ML1644 (270 aa). FASTA scores: opt: 1357, E(): 1.2e-72; 74.170% identity in 271 aa overlap T44717|3150235|CAA19213.1|AL023635 13093419|CAC30595.1|AL583922. X2BK64,P66884 No cell wall and cell processes Rv2235 NC_002945.3 Mycobrowser_v2 CDS 2490324 2490800 . - 0 Mb2263c CONSERVED HYPOTHETICAL PROTEIN Mb2263c, -, len: 158 aa. Equivalent to Rv2239c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins from Mycobacterium leprae (ML1649, 140 aa) and Streptomyces coelicolor A3(2) (SCC8A.28c, 159 aa). Equivalent to ML1649 conserved hypothetical protein (140 aa). FASTA scores: ML1649 conserved hypothetical protein (140 aa) opt: 846, E(): 6.5e-45; 86.429% identity in 140 aa overlap (tr|O69479|O69479 HYPOTHETICAL 15.2 KDA PROTEIN (140 aa); and opt: 447, E(): 1.2e-21; 50.355% identity (51.825% ungapped) in 141 aa overlap. Similarity with ML1649 suggests alternative start at 251198. X2BK67 No conserved hypotheticals Rv2239c NC_002945.3 Mycobrowser_v2 CDS 2491687 2494392 . + 0 Mb2265 aceE pyruvate dehydrogenase e1 component acee (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase) Mb2265, aceE, len: 901 aa. Equivalent to Rv2241,len: 901 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 901 aa overlap). Probable aceE,pyruvate dehydrogenase E1 component (EC 1.2.4.1), similar to others e.g. ODP1_ECOLI|P06958 pyruvate dehydrogenase E1 component from Escherichia coli, FASTA score: (51.2% identity in 891 aa overlap); etc. Q7TYW7 No intermediary metabolism and respiration Rv2241 NC_002945.3 Mycobrowser_v2 CDS 2494452 2495696 . + 0 Mb2266 CONSERVED HYPOTHETICAL PROTEIN Mb2266, -, len: 414 aa. Equivalent to Rv2242, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Conserved hypothetical protein. Equivalent to ML1652 conserved hypothetical protein from Mycobacterium leprae (414 aa),and ortholog in Streptomyces coelicolor A3(2). FASTA scores: ML1652 opt: 2369, E(): 4.2e-128; 88.406% identity in 414 aa overlap (AL023635)(AL583922). some similarity at 3' end with S25203 srmR protein - Streptomyces ambofaciens (604 aa) opt: 188 E(): 9e-05; (26.4% identity in 277 aa overlap) and with SW:YAEG_HAEIN P44509 hypothetical protein HI0093 (42.3% identity in 52 aa overlap). Contains possible helix-turn-helix motif at aa 360-381 (+3.52 SD) X2BKJ7,P63750 No conserved hypotheticals Rv2242 NC_002945.3 Mycobrowser_v2 CDS 2495935 2496843 . + 0 Mb2267 fabD MALONYL CoA-ACYL CARRIER PROTEIN TRANSACYLASE FABD (Malonyl CoA:AcpM acyltransferase) (MCT) Mb2267, fabD, len: 302 aa. Equivalent to Rv2243,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). fabD (alternate gene name: mtFabD), malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (see citations below), highly similar to e.g. A57356 acyl-CoA carrier protein malonyltransferase from Streptomyces coelicolor (316 aa),FASTA score: opt: 955, E(): 0, (52.6% identity in 304 aa overlap); FABD_HAEIN|P43712 malonyl CoA-acyl carrier protein transacylase from Haemophilus influenzae, FASTA score: (30.5% identity in 308 aa overlap); and FABD_ECOLI|P25715 from Escherichia coli, FASTA score: (31.4% identity in 309 aa overlap). X2BK93,P63459 No lipid metabolism Rv2243 NC_002945.3 Mycobrowser_v2 CDS 2496919 2497266 . + 0 Mb2268 acpM MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM Mb2268, acpM, len: 115 aa. Equivalent to Rv2244,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). acpM, acyl carrier protein, meromycolate precursor transport, involved in meromycolate extension (see citations below). Highly similar to others e.g. L43074|STMFABD2|STMFABD|g870805 acyl carrier protein from Streptomyces glaucescens (82 aa), FASTA scores: opt: 298, E(): 8.4e-13, (56.6% identity in 76 aa overlap); and ACP_ECOLI|P02901 acyl carrier protein from Escherichia coli, FASTA score: (37.3% identity in 67 aa overlap); etc. X2BK70,P0A4W7 No lipid metabolism Rv2244 NC_002945.3 Mycobrowser_v2 CDS 2497263 2498513 . + 0 Mb2269 kasA 3-OXOACYL-[ACYL-CARRIER PROTEIN] SYNTHASE 1 KASA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) Mb2269, kasA, len: 416 aa. Equivalent to Rv2245,len: 416 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 416 aa overlap). kasA,beta-ketoacyl-ACP synthase (EC 2.3.1.41), involved in meromycolate extension (see citations below): belongs to the FAS-II system, which utilizes primarily palmitoyl-ACP rather than short-chain acyl-ACP primers. Highly similar to others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP synthase from Streptomyces glaucescens (423 aa), FASTA scores: opt: 1105, E(): 0, (44.6% identity in 417 aa overlap); FABF_ECOLI|P39435 3-oxoacyl-[acyl-carrier-protein] synthase II from Escherichia coli, FASTA score: (39.4% identity in 254 aa overlap); FABB_HORVU|P23902 3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score: (33.4% identity in 413 aa overlap); etc. Strongest similarity to downstream ORF kasB|Rv2246|MTCY427.27 3-oxoacyl-[acyl-carrier-protein] synthase 2 from Mycobacterium tuberculosis (438 aa), FASTA score: (66.3% identity in 409 aa overlap). BELONGS TO THE BETA-KETOACYL-ACP SYNTHASES FAMILY. X2BKI6,P63455 No lipid metabolism Rv2245 NC_002945.3 Mycobrowser_v2 CDS 2506051 2506980 . + 0 Mb2276 diacylglycerol kinase Mb2276, -, len: 309 aa. Equivalent to Rv2252, len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Bacillus subtilis (e.g. BSUB0004_120), Streptomyces coelicolor A3(2) >emb|CAB61184.1| (AL132973) hypothetical protein SCF91.27c (293 aa) and P39074. FASTA scores: Z99107|BSUB0004_120 Bacillus subtilis complete genome (303 aa) opt: 397, E(): 1.7e-19; (26.4% identity in 299 aa overlap) and P390 74|BMRU_BACSU BMRU PROTEIN (297 aa) opt: 309, E(): 1.3e-13; (25.0% identity in 284 aa overlap). Q7TYW4 No lipid metabolism Rv2252 NC_002945.3 Mycobrowser_v2 CDS 2498544 2499860 . + 0 Mb2270 kasB 3-OXOACYL-[ACYL-CARRIER PROTEIN] SYNTHASE 2 KASB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) Mb2270, kasB, len: 438 aa. Equivalent to Rv2246,len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). kasB,beta-ketoacyl-ACP synthase (EC 2.3.1.41), involved in meromycolate extension (see citations below). Highly similar or similar to others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP synthase from Streptomyces glaucescens (423 aa), FASTA scores: opt: 1091, E(): 0, (44.7% identity in 416 aa overlap); FABF_ECOLI|P39435 3-oxoacyl-[acyl-carrier-protein] synthase II from Escherichia coli, FASTA score: (37.0% identity in 411 aa overlap); FABB_HORVU|P23902 3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score: (32.5% identity in 415 aa overlap); etc. Strongest similarity to upstream ORF Rv2245|kasA|MTCY427.26 3-oxoacyl-[acyl-carrier-protein] synthase 1 from Mycobacterium tuberculosis (416 aa), FASTA score: (66.3% identity in 409 aa overlap). BELONGS TO THE BETA-KETOACYL-ACP SYNTHASES FAMILY. X2BJP8,P63457 No lipid metabolism Rv2246 NC_002945.3 Mycobrowser_v2 CDS 2499891 2501312 . + 0 Mb2271 accD6 ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 Mb2271, accD6, len: 473 aa. Equivalent to Rv2247,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 473 aa overlap). accD6,Acetyl/Propionyl CoA Carboxylase, beta subunit (EC 6.4.1.3) (see citations below), highly similar to e.g. PCCB_RHOSO|Q06101 propionyl-CoA carboxylase beta chain,FASTA score: (75.1% identity in 437 aa overlap). Similar to many other Acetyl/Propionyl CoA Carboxylases from Mycobacterium tuberculosis. BELONGS TO THE ACCD / PCCB FAMILY. X2BKK0,P63408 No NC_002945.3 Mycobrowser_v2 CDS 2501420 2502235 . + 0 Mb2272 CONSERVED HYPOTHETICAL PROTEIN Mb2272, -, len: 271 aa. Equivalent to Rv2248, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 271 aa overlap). Conserved hypothetical protein. Very similar to hypothetical Mycobacterium tuberculosis proteins Rv3517, Rv1482c, Rv3555c, Rv3714c,Rv1073. FASTA score: MTCY06G11.02c MTCY6G11 NID: g1877284 - (289 aa) opt: 366 E(): 5.3e-18; (32.1% identity in 249 aa overlap). Some similarity to M. avium protein AF002133|AF0021 339 AF002133 NID: g2183254 (346 aa) opt: 308 E(): 5.2e-14; (28.3% identity in 254 aa overlap) Q7TYW6 No conserved hypotheticals Rv2248 NC_002945.3 Mycobrowser_v2 CDS 2502304 2503854 . - 0 Mb2273c glpD1 PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLPD1 Mb2273c, glpD1, len: 516 aa. Equivalent to Rv2249c,len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 516 aa overlap). Probable glpD1,glycerol-3-phosphate dehydrogenase, similar to SW:GLPD_ECOLI P13035 aerobic glycerol-3-phosphate dehydrogenase (30.0% identity in 486 aa overlap) and SW:GLPA_ECOLI P13032 anaerobic glycerol-3-phosphate dehydrogenase (28.2% identity in 504 aa overlap). Also similar to Rv3302c|glpD2 glycerol-3-phosphate dehydrogenase. COFACTOR: FAD (BY SIMILARITY). BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY. X2BK71,P64183 No NC_002945.3 Mycobrowser_v2 CDS 2503848 2504417 . - 0 Mb2274c Possible transcriptional regulatory protein Mb2274c, -, len: 189 aa. Equivalent to Rv2250c,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 189 aa overlap). Possible transcriptional regulatory protein, TetR family. Start unclear; ORF has been shortened since first submission to avoid overlap with Rv2251 (-30 aa). Contains probable helix-turn-helix motif (Score 2243, +6.70 SD) X2BKJ2,Q7VEN0 No regulatory proteins Rv2250c NC_002945.3 Mycobrowser_v2 CDS 2526703 2527893 . + 0 Mb2299 cyp121 Cytochrome P450 121 CYP121 Mb2299, cyp121, len: 396 aa. Equivalent to Rv2276,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). cyp121, cytochrome P450 (EC 1.14.-.-) (see citation below), similar to e.g. G303644 (397 aa) opt: 675, z-score: 776.4, E(): 2.7e-36,(33.7% identity in 407 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY339.42, 29.2% identity in 298 aa overlap. X2BJT7,P0A515 No NC_002945.3 Mycobrowser_v2 CDS 2504465 2506054 . + 0 Mb2275 POSSIBLE FLAVOPROTEIN Mb2275, -, len: 529 aa. Similar to 5' end of Rv2250A and 3' end of Rv2251, len: 139 aa and 475 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 108 aa overlap and 98.2% identity in 433 aa overlap). Rv2250A: Conserved hypothetical protein, possibly flavoprotein. Similar to N-terminus of SCF91.28c|AL132973_28 possible flavoprotein from Streptomyces coelicolor (530 aa), FASTA scores: opt: 240,E(): 1.1e-07, (39.25% identity in 107 aa overlap). Possible frameshift between nt 2525723 to 2525727. The sequences of CDC 1551 and Mycobacterium bovis are missing a single G base. Rv2251: Possible flavoprotein, probably continuation of Rv2250A, similar to MTCY164.18 from Mycobacterium tuberculosis and to several ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASES (e.g. O00116). Also some similarity to D-lactate dehydrogenases. FASTA scores: sptr|O05784|O05784 HYPOTHETICAL 56.5 KD PROTEIN. (527 aa) opt: 1019 E(): 0; (38.6% identity in 487 aa overlap) and sp|O00116|ADAS_HUMAN ALKYLDIHYDROXYACETON EPHOSPHATE SYNTHASE PRECURSOR (EC 2.5.1.26) (658 aa) opt: 558 E(): 6.2e-27; (31.3% identity in 447 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base deletion (g-*) leads to a single product. Q7TYW5 No NC_002945.3 Mycobrowser_v2 CDS 2508403 2508936 . - 0 Mb2280c CONSERVED HYPOTHETICAL PROTEIN Mb2280c, -, len: 177 aa. Equivalent to Rv2256c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 177 aa overlap). Conserved hypothetical protein, similar to Streptomyces glaucescens ORF5 (164 aa) and Streptomyces coelicolor hypothetical protein SC4A7.19c (164 aa; emb|CAB62723.1|AL133423). FASTA scores: sptr|Q54209|Q54209 FABD, FABH, FABC, FABB, AND ORF5 (164 aa) opt: 504, E(): 3.9e-27; (44.4% identity in 162 aa overlap). Q7TYW2 No conserved hypotheticals Rv2256c NC_002945.3 Mycobrowser_v2 CDS 2509066 2509884 . - 0 Mb2281c conserved protein Mb2281c, -, len: 272 aa. Equivalent to Rv2257c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, similar to hypothetical protein SC4A7.08 from Streptomyces coelicolor (273 aa; 58% identity in 243 aa overlap). Also similar to several putative esterases and penicillin-binding proteins in M. tuberculosis e.g. Rv1923, Rv1497, Rv2463, Rv3775, Rv1922,Rv1730c. Q7TYW1 No conserved hypotheticals Rv2257c NC_002945.3 Mycobrowser_v2 CDS 2509898 2510959 . - 0 Mb2282c Possible transcriptional regulatory protein Mb2282c, -, len: 353 aa. Equivalent to Rv2258c,len:353 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 353 aa overlap). Possible transcriptional regulatory protein, similar to several hypothetical proteins from C. elegans. FASTA scores: sptr|O01593|O01593 CODED FOR BY C. ELEGANS CDNA YK102 F (365 aa) opt: 577, E(): 6.4e-31; (30.5% identity in 341 aa overlap). Contains possible helix-turn helix motif at aa 47-68 (+3.65 SD) Q7VEM7 No NC_002945.3 Mycobrowser_v2 CDS 2511201 2512286 . + 0 Mb2283 mscr s-nitrosomycothiol reductase mscr Mb2283, adhE2, len: 361 aa. Equivalent to Rv2259,len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 361 aa overlap). Probable adhE2,zinc-containing alcohol dehydrogenase, similar to several,especially mycothiol-dependent formaldehyde dehydrogenase from Amycolatopsis methanolica P80094 (360 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. FASTA scores: >sp|P80094|FADH_AMYME NAD/MYCOTHIOL-DEPENDENT FORMALDEHYDE DEHYDROGENASE (MD-FALDH) Length = 360, Expect = e-156, Identities = 268/358 (74%). Also similar to Rv0162c, (MTCI28.02c, 35.0% identity in 371 aa overlap). Q7VEM6 No NC_002945.3 Mycobrowser_v2 CDS 2512286 2512921 . + 0 Mb2284 CONSERVED HYPOTHETICAL PROTEIN Mb2284, -, len: 211 aa. Equivalent to Rv2260, len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins Rv0634c, Rv1637c, Rv3677c, Rv2581c from Mycobacterium tuberculosis and to various hydrolases. FASTA scores: sptr|O06154|O06154 HYPOTHETICAL 21.3 KD PROTEIN (200 aa) opt: 355, E(): 4e-15; (37.4% identity in 198 aa overlap). Q7TYW0 No conserved hypotheticals Rv2260 NC_002945.3 Mycobrowser_v2 CDS 2521761 2523230 . - 0 Mb2291c cyp128 PROBABLE CYTOCHROME P450 128 CYP128 Mb2291c, cyp128, len: 489 aa. Equivalent to Rv2268c, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 489 aa overlap). Probable cyp128, cytochrome P450 (EC 1.14.-.-), similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620,E(): 8.3e-33, (31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature, similar to MTCY50.26, 32.7% identity in 382 aa overlap X2BKL8,P63714 No intermediary metabolism and respiration Rv2268c NC_002945.3 Mycobrowser_v2 CDS 2512998 2514506 . - 0 Mb2285c CONSERVED HYPOTHETICAL PROTEIN Mb2285c, -, len: 502 aa. Equivalent to Rv2262c and Rv2261c, len: 360 aa and 140 aa, from Mycobacterium tuberculosis strain H37Rv, (94.7% identity in 357 aa overlap and 100.0% identity in 140 aa overlap). Conserved hypothetical protein, with function unknown but some similarity to N-terminal 70% of P23930|P77703|LNT_ECOLI|CUTE|B0657 APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) from Escherichia coli strain K12 (512 aa), FASTA scores: opt: 239, E(): 1.6e-07,(30.4% identity in 359 aa overlap). Note that neighboring ORF shows similarity to N -terminal part of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp.,suggesting possibility of frameshift. Sequence of clones from two sources has been checked but no error found. Appear to be two extra bases at position 1876970 compared to CDC1551 strain. Conserved hypothetical protein, with function unknown but some similarity to C-terminal end of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp. Note that next ORF shows similarity to N-terminal part of P74055 APOLIPOPROTEIN N-ACYLTRANSFERASE from Escherichia coli (519 aa), FASTA scores: opt: 142,E(): 0.007, (29.9% identity in 117 aa overlap), suggesting possible frameshift. Sequence of clones from two sources has been checked but no error found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2262c and Rv2261c exist as 2 genes. In Mycobacterium bovis, a 2 bp deletion (ct-*) results in a single product which is more similar to Rv2262c. Q7TYV9 No lipid metabolism Rv2262c NC_002945.3 Mycobrowser_v2 CDS 2514595 2515548 . + 0 Mb2286 Possible oxidoreductase Mb2286, -, len: 317 aa. Equivalent to Rv2263, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 PROBABLY AN NADP-DEPENDENT OXIDOREDUCTASE (297 aa) opt: 487, E(): 1.1e-23; (36.1% identity in 299 aa overlap). Also similar to M. tuberculosis Rv0068, and Rv0439c. Q7VEM5 No intermediary metabolism and respiration Rv2263 NC_002945.3 Mycobrowser_v2 CDS 2525837 2526706 . + 0 Mb2298 CONSERVED HYPOTHETICAL PROTEIN Mb2298, -, len: 289 aa. Equivalent to Rv2275, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Conserved hypothetical protein. Some similarity to Bacillus subtilis sp|O34351|O34351 YVMC (248 aa), FASTA score: opt: 280,E(): 2.7e -11; 28.2% identity in 227 aa overlap Q7TYV7 No conserved hypotheticals Rv2275 NC_002945.3 Mycobrowser_v2 CDS 2515526 2517304 . - 0 Mb2287c conserved hypothetical proline rich protein Mb2287c, -, len: 592 aa. Equivalent to Rv2264c,len: 592 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 592 aa overlap). Conserved hypothetical Pro-rich protein, similar to hypothetical proteins Rv0312 (MTCY63.17, 620 aa and Rv0350) that has highly Pro-, Thr-rich C-terminus. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. FASTA scores: Z96800|MTCY63_17 Mycobacterium tuberculosis cosmid (620 aa) opt: 1075, E(): 8.8e-24; (38.9% identity in 627 aa overlap). Q7VEM4 No conserved hypotheticals Rv2264c NC_002945.3 Mycobrowser_v2 CDS 2517654 2518883 . + 0 Mb2288 Possible conserved integral membrane protein Mb2288, -, len: 409 aa. Equivalent to Rv2265, len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Possible conserved integral membrane protein, with some similarity to others e.g. M. thermoauto. sp|O26855|O26855 CONSERVED PROTEIN (383 aa), FASTA score: opt: 898 z-score: 1023.5 E(): 0; 38.0% identity in 384 aa overlap; Q58713 HYPOTHETICAL 44.1 KD PROTEIN 1 317 (398 aa), FASTA scores, opt: 305 E(): 1.2e-11; 22.8% identity in 382 aa overlap; also KGTP_ECOLI P17448 alpha-ketoglutarate permease (432 aa), FASTA scores, opt: 156, E(): 0.006, (24.8% identity in 416 aa overlap) X2BK80,P64962 No cell wall and cell processes Rv2265 NC_002945.3 Mycobrowser_v2 CDS 2519058 2520344 . + 0 Mb2289 cyp124 Probable cytochrome P450 124 CYP124 Mb2289, cyp124, len: 428 aa. Equivalent to Rv2266,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). Probable cyp124,cytochrome P450 (EC 1.14.-.-), similar to e.g. G405543 cytochrome P450 (406 aa), FASTA scores, opt: 763,E(): 0,(35.4% identity in 393 aa overlap), similar to e.g. MTCY50.26, 33.8% identity in 370 aa overlap X2BKK6,P0A517 No NC_002945.3 Mycobrowser_v2 CDS 2520598 2521764 . - 0 Mb2290c CONSERVED HYPOTHETICAL PROTEIN Mb2290c, -, len: 388 aa. Equivalent to Rv2267c,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Conserved hypothetical protein; some similarity to Mycobacterium tuberculosis Rv3529c; gp|Z82098|MTCY3C7_27 (384 aa) FASTA score: opt: 261, E(): 3.6e-10; 27.3% identity in 253 aa overlap X2BJR9 No conserved hypotheticals Rv2267c NC_002945.3 Mycobrowser_v2 CDS 2533741 2535036 . + 0 Mb2305 lipM Probable esterase LipM Mb2305, lipM, len: 431 aa. Equivalent to Rv2284,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). Probable lipM,esterase (EC 3.1.-.-), similar to others e.g. gp|Z95844|MTCY493_28 from Mycobacterium tuberculosis cosmid (420 aa), FASTA scores: opt: 1266, E(): 0, (50.1% identity in 411 aa overlap). Some similarity to G537514 arylacetamide deacetylase (399 aa), FASTA scores: opt: 190, E(): 5.9e-05, (30.4% identity in 138 aa overlap). Q7VEM0 No intermediary metabolism and respiration Rv2284 NC_002945.3 Mycobrowser_v2 CDS 2528078 2528977 . - 0 Mb2300c Possible glycerolphosphodiesterase Mb2300c, -, len: 299 aa. Equivalent to Rv2277c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.661% identity in 295 aa overlap). Possible glycerolphosphodiesterase, similar to e.g. UGPQ_ECOLI P10908 glycerophosphoryldiester phosphodiesterase (cytosolic) (247 aa), FASTA scores, opt: 149, E(): 0.0061,(27.2% identity in 195 aa overlap). Start of protein uncertain, encoded by neighbouring IS6110 as given, is intact in Mycobacterium tuberculosis CDC1551. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 1358 bp deletion containing an IS6110 sequence prior to the start of Mb2300c disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Q7VEM2 No intermediary metabolism and respiration Rv2277c NC_002945.3 Mycobrowser_v2 CDS 2529156 2530535 . + 0 Mb2301 Probable dehydrogenase Mb2301, -, len: 459 aa. Equivalent to Rv2280, len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap Q7VEM1 No intermediary metabolism and respiration Rv2280 NC_002945.3 Mycobrowser_v2 CDS 2530769 2532427 . + 0 Mb2302 pitB Putative phosphate-transport permease PitB Mb2302, pitB, len: 552 aa. Equivalent to Rv2281,len: 552 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 552 aa overlap). Putative pitB,phosphate-transport permease, integral membrane protein,similar to YG04_HAEIN P45268 putative phosphate permease hi1604 (420 aa). FASTA scores, opt: 484, E(): 5e-23,(33.5% identity in 498 aa overlap) also to G399598 amphotropic murine retrovirus receptor (656 aa) FASTA scores, opt: 453, E(): 5.8e-21, (26.8% identity in 645 aa overlap). Also similar to Rv0545c|pitA from M. tuberculosis. BELONGS TO THE PIT SUBFAMILY. X2BK88,P65713 No cell wall and cell processes Rv2281 NC_002945.3 Mycobrowser_v2 CDS 2532534 2533472 . - 0 Mb2303c Probable transcription regulator (lysR family) Mb2303c, -, len: 312 aa. Equivalent to Rv2282c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 312 aa overlap). Probable transcriptional regulator, lysR family, similar to others e.g. YC30_CYAPA|P48271 hypothetical transcriptional regulator YCF30 (324 aa), FASTA scores: opt: 292, E(): 4e-12, (27.6% identity in 286 aa overlap); etc. Also similar to Rv0377|MTCY39.34 from Mycobacterium tuberculosis, FASTA score: (25.4% identity in 268 aa overlap). Contains PS00044 Bacterial regulatory proteins,lysR family signature, and contains helix-turn-helix motif at aa 24 -45 (+4.93 SD). X2BKM0,P67668 No regulatory proteins Rv2282c NC_002945.3 Mycobrowser_v2 CDS 2533537 2533731 . + 0 Mb2304 HYPOTHETICAL PROTEIN Mb2304, -, len: 64 aa. Equivalent to Rv2283, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Unknown protein; questionable ORF X2BJU4 No conserved hypotheticals Rv2283 NC_002945.3 Mycobrowser_v2 CDS 2739807 2740310 . - 0 Mb2495c conserved protein Mb2495c, -, len: 167 aa. Equivalent to Rv2468c,len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Conserved hypothetical protein, highly similar to Mycobacterium leprae HYPOTHETICAL PROTEINS Q9CC58|ML1255 (163 aa), FASTA scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa overlap) and Q9X7B5|MLCB1610.16 (169 aa), FASTA scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa overlap). Also weak similarity with Q9X8D7|SCE39.14c PUTATIVE GNTR-FAMILY REGULATOR from Streptomyces coelicolor (243 aa), FASTA scores: opt: 116, E(): 1.3,(30.1% identity in 156 aa overlap). Q7TYI6 No conserved hypotheticals Rv2468c NC_002945.3 Mycobrowser_v2 CDS 2535069 2536406 . + 0 Mb2306 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb2306, -, len: 445 aa. Equivalent to Rv2285, len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Conserved hypothetical protein, member of Mycobacterium tuberculosis 15-membered protein family including Rv3740c, Rv3734c,Rv1425, Rv1760, Rv0895, Rv3480c. FASTA scores: gp|Z95844|MTCY493_29 Mycobacterium tuberculosis cosmid (459 aa) opt: 640, E(): 0; 33.4% identity in 470 aa overlap. X2BKE0,P67207 No lipid metabolism Rv2285 NC_002945.3 Mycobrowser_v2 CDS 2536473 2536736 . - 0 Mb2307c conserved hypothetical protein [SECOND PART] Mb2307c, -, len: 87 aa. Equivalent to 3' end of Rv2286c, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv, (). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein,Rv2466c, AL021246|MTV008_22 (207 aa). FASTA score: opt: 324, E(): 8.9e-15; 30.4% identity in 194 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2286c into 2 parts, Mb2307c and Mb2308c. Q7VEL9 No NC_002945.3 Mycobrowser_v2 CDS 2536764 2537165 . - 0 Mb2308c conserved hypothetical protein [FIRST PART] Mb2308c, -, len: 133 aa. Equivalent to 5' end of Rv2286c, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 133 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein, Rv2466c,AL021246|MTV008_22 (207 aa). FASTA score: opt: 324, E(): 8.9e-15; 30.4% identity in 194 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2286c into 2 parts, Mb2307c and Mb2308c. Q7VEL8 No NC_002945.3 Mycobrowser_v2 CDS 2546033 2546485 . + 0 Mb2319 unknown protein Mb2319, -, len: 150 aa. Equivalent to Rv2297, len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 150 aa overlap). Unknown protein; contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide X2BJX4 No conserved hypotheticals Rv2297 NC_002945.3 Mycobrowser_v2 CDS 2537299 2538927 . + 0 Mb2309 yjcE Probable conserved integral membrane transport protein YjcE Mb2309, yjcE, len: 542 aa. Equivalent to Rv2287,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 542 aa overlap). Probable yjcE,conserved integral membrane transport protein, similar to eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065 Putative Na(+)/H(+) exchanger from Escherichia coli (549 aa), FASTA scores: opt: 436, E(): 5.6e-21, (29.4% identity in 555 aa overlap); etc. SEEMS TO BELONG TO CPA1 FAMILY (NA(+)/H(+) EXCHANGER FAMILY). X2BJV4,P65527 No cell wall and cell processes Rv2287 NC_002945.3 Mycobrowser_v2 CDS 2538924 2539301 . + 0 Mb2310 HYPOTHETICAL PROTEIN Mb2310, -, len: 125 aa. Equivalent to Rv2288, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Unknown hypothetical protein X2BKN7 No conserved hypotheticals Rv2288 NC_002945.3 Mycobrowser_v2 CDS 2539271 2540053 . + 0 Mb2311 cdh Probable CDP-diacylglycerol pyrophosphatase Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase) Mb2311, cdh, len: 260 aa. Equivalent to Rv2289,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Probable cdh,CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26), similar to CDH_SALTY|P26219 cdp-diacylglycerol pyrophosphatase (251 aa), FASTA scores: opt: 395, E(): 5.9e-20, (33.5% identity in 221 aa overlap). X2BKE3,P63752 No lipid metabolism Rv2289 NC_002945.3 Mycobrowser_v2 CDS 2540195 2540350 . + 0 Mb2312 lppOa Probable conserved lipoprotein lppOa Mb2312, lppOa, len: 51 aa. Equivalent to 5' end of Rv2290, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 39 aa overlap). Probable lppO, conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kd lipoprotein antigen precursor (159 aa) FASTA scores, opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). ???Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, lppO exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb. Q7VEL7 No NC_002945.3 Mycobrowser_v2 CDS 2540344 2540709 . + 0 Mb2313 lppOb Probable conserved lipoprotein lppOb Mb2313, lppOb, len: 121 aa. Equivalent to 3' end of Rv2290, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 121 aa overlap). Probable lppO, conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kd lipoprotein antigen precursor (159 aa) FASTA scores, opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, lppO exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb. Q7VEL6 No NC_002945.3 Mycobrowser_v2 CDS 2740261 2740494 . - 0 MB2495A Conserved protein MB2495A, len: 77 aa. Equivalent to Rv2468A len: 77 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 77 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BKM4 No conserved hypotheticals Rv2468A NC_002945.3 Mycobrowser_v2 CDS 2540851 2541621 . + 0 Mb2314 sseB Probable thiosulfate sulfurtransferase SseB Mb2314, sseB, len: 256 aa. Equivalent to 3' end of Rv2291, len: 284 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 256 aa overlap). Probable sseB, thiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0; Smith-Waterman score: 765; 46.9% identity in 286 aa overlap, similar to THTR_ECOLI P31142 putative thiosulfate sulfurtransferase (280 aa), FASTA scores, opt: 478, E(): 1e-23, (35.1% identity in 265 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 5' start due to a 2 bp deletion (tg-*),leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (256 aa versus 284 aa). Q7VEL5 No NC_002945.3 Mycobrowser_v2 CDS 2594783 2595178 . + 0 Mb2368 mmpL9b PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL9B [SECOND PART] Mb2368, mmpL9b, len: 131 aa. Equivalent to 3' end of Rv2339, len: 962 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 131 aa overlap). Probable mmpL9, conserved transmembrane transport protein (see citation below), with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity in 937 aa overlap); G699237|U1740AB from Mycobacterium leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from M. tuberculosis. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, truncation due to a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b. Q7TYS5 No NC_002945.3 Mycobrowser_v2 CDS 2541622 2542626 . - 0 Mb2315c hypothetical protein Mb2315c, -, len: 334 aa. Similar to Rv2293c and Rv2292c, len: 246 aa and 74 aa, from Mycobacterium tuberculosis strain H37Rv, (92.2% identity in 245 aa overlap and 100.0% identity in 74 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein (299 aa) AAK24237.1| (AE005897) belonging to phosphorylase family [Caulobacter crescentus] (33% identity in 131 aa overlap). Possible lipoprotein: signal peptide at N-terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-g) results in a single product which is more similar to Rv2293c. X2BKP3,P64978 No NC_002945.3 Mycobrowser_v2 CDS 2542921 2544144 . + 0 Mb2316 Probable aminotransferase Mb2316, -, len: 407 aa. Equivalent to Rv2294, len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Probable aminotransferase (EC 2.6.1.-), similar to others in M. tuberculosis e.g. MTV030_19, also similar to PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa), FASTA scores: opt: 563, E(): 2 .8e-29, (31.4% identity in 408 aa overlap); and to MALY_ECOLI|P23256 maly protein from Escherichia coli (390 aa), FASTA scores: opt: 530, E(): 3.6e-27, (31.3% identity in 384 aa overlap). BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. X2BKE7,P63503 No intermediary metabolism and respiration Rv2294 NC_002945.3 Mycobrowser_v2 CDS 2544367 2545005 . + 0 Mb2317 CONSERVED HYPOTHETICAL PROTEIN Mb2317, -, len: 212 aa. Equivalent to Rv2295, len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 212 aa overlap). Conserved hypothetical protein, cysteine-rich protein, similar to YIEJ_ECOLI P31469 hypothetical 22.5 kd protein in tnab-bglb intergenic region (195 aa), opt: 270, E(): 3.4e-11, (36.4% identity in 198 aa overlap). Alternative start suggested by similarity 26 codons further downstream X2BK96 No conserved hypotheticals Rv2295 NC_002945.3 Mycobrowser_v2 CDS 2545099 2546001 . + 0 Mb2318 Probable haloalkane dehalogenase Mb2318, -, len: 300 aa. Equivalent to Rv2296, len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable haloalkane dehalogenase (EC 3.8.1.5), similar to e.g. HALO_XANAU P22643, haloalkane dehalogenase, (310 aa), opt: 510 z-score: 577.7 E(): 3.1e-25 (39.0% identity in 315 aa overlap). X2BKN5,P64302 No intermediary metabolism and respiration Rv2296 NC_002945.3 Mycobrowser_v2 CDS 2546677 2547648 . + 0 Mb2320 conserved protein Mb2320, -, len: 323 aa. Equivalent to Rv2298, len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Conserved hypothetical protein. Similar to SLR0545 Synechocystis sp,Q55493 hypothetical 34.6 kDa protein (314 aa), FASTA scores, opt: 427, E(): 1.7e-20, (39.3% identity in 303 aa overlap) and to YZAE_BACSU P46905 hypothetical protein in natb 3'region (268 aa) FASTA scores, opt: 370, E(): 6.1e-17, (31.4% identity in 264 aa overlap) X2BKP9,P63485 No conserved hypotheticals Rv2298 NC_002945.3 Mycobrowser_v2 CDS 2554703 2555296 . + 0 Mb2328 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb2328, -, len: 197 aa. Equivalent to Rv2306A, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Possible conserved membrane protein, similar to several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor, e.g. Rv0625c|P96915|Y625_MYCTU HYPOTHETICAL 25.2 KDA PROTEIN from Mycobacterium tuberculosis (246 aa),FASTA scores: opt: 410, E(): 2.7e-17, (53.25% identity in 139 aa overlap). First 140 aa show high similarity, this then decreases but continues in next ORF Rv2306B,suggesting a frameshift near nt 2577473. However the sequence has been checked and no error found. The sequence is identical in CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand. Q7TYV4 No cell wall and cell processes Rv2306A NC_002945.3 Mycobrowser_v2 CDS 2547654 2549597 . - 0 Mb2321c htpG PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Mb2321c, htpG, len: 647 aa. Equivalent to Rv2299c,len: 647 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 647 aa overlap). htpG, probable chaperone, HSP90 familyHEAT SHOCK PROTEIN HSP90 FAMILY. Similar to HTPG_BACSU|P46208 heat shock protein htpG homologue from Bacillus subtilis (626 aa), FASTA scores: opt: 1551, E(): 0, (39.6% identity in 631 aa overlap). Contains possible helix-turn-helix motif at aa 519-540 (+3.77 SD). BELONGS TO THE HEAT SHOCK PROTEIN 90 FAMILY. X2BKF3,P64412 No NC_002945.3 Mycobrowser_v2 CDS 2549671 2550603 . - 0 Mb2322c conserved protein Mb2322c, -, len: 310 aa. Equivalent to Rv2300c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Conserved hypothetical protein, similar to others e.g. Q9RXY2|DR0172 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (271 aa), FASTA scores: opt: 306, E(): 1.3e-12, (34.6% identity in 229 aa overlap); Q9HZH1|PA3037 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (288 aa),FASTA scores: opt: 248, E(): 7.9e-09, (31.5% identity in 238 aa overlap); Q9PDL8|XF1361 HYPOTHETICAL PROTEIN from Xylella fastidiosa (279 aa), FASTA scores: opt: 236, E(): 4.6e-08, (29.7% identity in 249 aa overlap); U70053|XCU70053_3 GumP PROTEIN from Xanthomonas campestris (282 aa), FASTA scores: opt: 222, E(): 3.7e-07, (30.1% identity in 248 aa overlap); etc. X2BK98,P64982 No conserved hypotheticals Rv2300c NC_002945.3 Mycobrowser_v2 CDS 2569443 2570321 . - 0 Mb2346c universal stress protein family protein Mb2346c, -, len: 292 aa. Equivalent to Rv2319c,len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Hypothetical unknown protein. X2BKH4,P64996 No virulence, detoxification, adaptation Rv2319c NC_002945.3 Mycobrowser_v2 CDS 2550610 2551302 . + 0 Mb2323 cut2 PROBABLE CUTINASE CUT2 Mb2323, cut2, len: 230 aa. Equivalent to Rv2301,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Probable cut2 (alternate gene name: cfp25), cutinase (EC 3.1.1.-),highly similar to others from Mycobacteria tuberculosis e.g. MTCY13E12.04|Rv3451|O06318|CUT3_MYCTU (247 aa), FASTA scores: opt: 569, E(): 2.3e-27, (45.3% identity in 223 aa overlap); MT2037|MTCY39.35|RV1984C|Q10837|CUT1_MYCTU (217 aa), FASTA scores: opt: 383, E(): 3.4e-16 (42.9% identity in 217 aa overlap); O69691|Rv3724|MTV025.072 PUTATIVE CUTINASE PRECURSOR (187 aa), FASTA scores: opt: 248, E(): 4.3e-08, (41.85% identity in 172 aa overlap); etc. Also similar to few others from other organisms e.g. Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 391, E(): 1.1e-16, (39.15% identity in 235 aa overlap); etc. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. BELONGS TO THE CUTINASE FAMILY. Start changed since first submission (+11 aa). X2BKP1,P63882 No cell wall and cell processes Rv2301 NC_002945.3 Mycobrowser_v2 CDS 2551408 2551650 . + 0 Mb2324 conserved protein Mb2324, -, len: 80 aa. Equivalent to Rv2302, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Conserved hypothetical protein, highly similar to others: O53766|AL021942|Rv0569|MTV039.07 HYPOTHETICAL 9.5 KDA PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: 300, E(): 1.4e-14, (61.85% identity in 76 aa overlap); O88049|SCI35.11 HYPOTHETICAL 7.1 KDA PROTEIN from Streptomyces coelicolor (64 aa), FASTA scores: opt: 169, E(): 1.5e-05, (46.55% identity in 58 aa overlap) (has its C-terminus shorter); Q9XCD1 HYPOTHETICAL 12.0 KDA PROTEIN (FRAGMENT) from Thermomonospora fusca (106 aa),FASTA scores: opt: 126, E(): 0.023, (50.0% identity in 34 aa overlap) (similarity in part for this one). Also weakly similar to U650M|G699303|Q50105 HYPOTHETICAL 5.7 KDA PROTEIN from Mycobacterium leprae (53 aa), FASTA scores: opt: 89, E(): 0.66, (45.5% identity in 33 aa overlap); and weakly similar to N-terminus of Q9RIZ1|SCJ1.23c putative DNA-binding protein from Streptomyces coelicolor (323 aa),FASTA scores: opt: 182, E(): 7.3e-06, (42.25% identity in 71 aa overlap). X2BJY1 No conserved hypotheticals Rv2302 NC_002945.3 Mycobrowser_v2 CDS 2551691 2552614 . - 0 Mb2325c PROBABLE ANTIBIOTIC-RESISTANCE PROTEIN Mb2325c, -, len: 307 aa. Equivalent to Rv2303c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Probable antibiotic-resistance protein, with some similarity to Q54229|G153373 macrotetrolide antibiotic-resistance protein (NONR) from Streptomyces griseus (347 aa) (see the first citation below), FASTA scores: opt: 438, E(): 3.1e-21, (33.2% identity in 226 aa overlap); and other hypothetical proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 252,E(): 3.5e-09, (25.5% identity in 286 aa overlap). Also similar to Mycobacterium tuberculosis Rv3510c|O53555|MTV023.17. Note that the protein Q9XDF3|NONC from Streptomyces griseus subsp. griseus (317 aa) is equivalent to Q54229|G153373|NONR however the N-terminal end is shorter (30 aa) owing to a changed start codon (see the second citation below). Q7TYV6 No virulence, detoxification, adaptation Rv2303c NC_002945.3 Mycobrowser_v2 CDS 2552611 2552820 . - 0 Mb2326c HYPOTHETICAL PROTEIN Mb2326c, -, len: 69 aa. Equivalent to Rv2304c, len: 69 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 69 aa overlap). Hypothetical unknown protein. X2BKF8 No conserved hypotheticals Rv2304c NC_002945.3 Mycobrowser_v2 CDS 2553404 2554693 . + 0 Mb2327 unknown protein Mb2327, -, len: 429 aa. Equivalent to Rv2305, len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 429 aa overlap). Hypothetical unknown protein. Q7TYV5 No conserved hypotheticals Rv2305 NC_002945.3 Mycobrowser_v2 CDS 2555083 2555517 . + 0 Mb2329 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb2329, -, len: 144 aa. Equivalent to Rv2306B, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible conserved membrane protein, similar to C-terminal part of several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor e.g. P96915|Y625_MYCTU|RV0625c HYPOTHETICAL 25.2 KDA PROTEIN from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 480, E(): 5e-24, (77.15% identity in 92 aa overlap). Could be a continuation of Rv2306A suggesting there may be a frameshift near nt 2577473. The C-terminal part is longer than Rv0625c and the 3'-end of gene overlaps Rv2307c, so maybe a further framehift. However, sequence has been checked and no error found. Also same sequence as strain CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand. Q7TYV3 No cell wall and cell processes Rv2306B NC_002945.3 Mycobrowser_v2 CDS 2555446 2556291 . - 0 Mb2330c CONSERVED HYPOTHETICAL PROTEIN Mb2330c, -, len: 281 aa. Equivalent to Rv2307c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 281 aa overlap). Conserved hypothetical protein, similar to many other hypothetical proteins and BEM1/BUD5 suppressors e.g. P77538 HYPOTHETICAL PROTEIN from Escherichia coli (293 aa), FASTA scores: opt: 421,E(): 2.4e-18, (32.1% identity in 268 aa overlap) (alias AAG57647|Z3802|BAB36823|ECS3400 Putative enzyme (3.4.-) from Escherichia coli (293 aa), FASTA scores: opt: 425,E(): 1.7e-18, (32.1% identity in 268 aa overlap));P54069|BE46_SCHPO|BEM46|SPBC32H8.03|PI020 BEM46 PROTEIN from Schizosaccharomyces pombe (Fission yeast) (352 aa), FASTA scores: opt: 355, E(): 3.3e-14, (30.45% identity in 279 aa overlap); O76462|BEM46 BEM46 PROTEIN from Drosophila melanogaster (338 aa), FASTA scores: opt: 404, E(): 2.8e-17, (32.75% identity in 281 aa overlap); etc. Equivalent (but with few differences) to AAK46650|MT2364 protein from Mycobacterium tuberculosis strain CDC1551 (281 aa). Q7TYV2 No conserved hypotheticals Rv2307c NC_002945.3 Mycobrowser_v2 CDS 2558014 2558730 . + 0 Mb2334 CONSERVED HYPOTHETICAL PROTEIN Mb2334, -, len: 238 aa. Equivalent to Rv2308, len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 238 aa overlap). Conserved hypothetical protein, sharing similarity with O53464|Rv2018|MTV018.05 from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 142, E(): 0.034, (24.8% identity in 250 aa overlap). As contains possible helix-turn-helix motif at aa 16-37 (Sequence: YVYAEVDKLIGLPAGTAKRWIN) (Score 1169, +3.17 SD),may be a transcriptional regulator. Q7TYU8 No conserved hypotheticals Rv2308 NC_002945.3 Mycobrowser_v2 CDS 2559438 2559893 . - 0 Mb2335c POSSIBLE INTEGRASE (FRAGMENT) Mb2335c, -, len: 151 aa. Equivalent to Rv2309c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Possible integrase (fragment), similar to others e.g. Q48908 INTEGRASE (FRAGMENT) from Mycobacterium paratuberculos (191 aa),FASTA scores: opt: 279, E(): 3.2e-11, (40.4% identity in 136 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1055|MTV017.08 INTEGRASE (FRAGMENT) (78 aa) (72.85% identity in 70 aa overlap); and Rv1054|MTV017.07 INTEGRASE (FRAGMENT). COULD BELONG TO THE 'PHAGE' INTEGRASE FAMILY. Q7TYU7 No insertion seqs and phages Rv2309c NC_002945.3 Mycobrowser_v2 CDS 2560640 2560927 . + 0 Mb2336 HYPOTHETICAL PROTEIN Mb2336, -, len: 95 aa. Equivalent to Rv2309A, len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 95 aa overlap). Hypothetical unknown protein. Equivalent to AAK46663 from Mycobacterium tuberculosis strain CDC1551 (95 aa) but longer 13 aa. Q7TYU6 No conserved hypotheticals Rv2309A NC_002945.3 Mycobrowser_v2 CDS 2561030 2561374 . + 0 Mb2337 POSSIBLE EXCISIONASE Mb2337, -, len: 114 aa. Equivalent to Rv2310, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Possible excisionase,showing some similarity to others e.g. Q9LCU5 PUTATIVE EXCISIONASE from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 341, E(): 6.6e-15, (48.2% identity in 110 aa overlap); O85865 PUTATIVE EXCISIONASE from Sphingomonas aromaticivorans (152 aa), FASTA scores: opt: 205, E(): 2.2e-06, (41.25% identity in 80 aa overlap); etc. Also similar to Rv3750c|O69717 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 228, E(): 6.9e-08, (43.9% identity in 82 aa overlap). Contains possible helix-turn-helix motif at aa 20-41 (Score 2181, +6.62 SD). X2BKA7,P64988 No insertion seqs and phages Rv2310 NC_002945.3 Mycobrowser_v2 CDS 2561479 2562003 . + 0 Mb2338 CONSERVED HYPOTHETICAL PROTEIN Mb2338, -, len: 174 aa. Equivalent to Rv2311, len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Conserved hypothetical protein, with similarity (in part) to transfer proteins homologous TRAA e.g. Q9EUN8|TRAA TRANSFER PROTEIN HOMOLOG TRAA from Corynebacterium glutamicum (1160 aa), FASTA scores: opt: 221, E(): 2.9e-07, (36.8% identity in 136 aa overlap); Q9ETQ3|TRAA CONJUGAL TRANSFER PROTEIN (TRAA-LIKE PROTEIN) from Corynebacterium equii (1367 aa), FASTA scores: opt: 188,E(): 5.5e-05, (33% identity in 106 aa overlap); P55418|TRAA_RHISN|Y4DS PROBABLE CONJUGAL TRANSFER PROTEIN from Rhizobium sp. strain NGR234 (1102 aa), FASTA scores: opt: 145, E(): 0.035, (29.08% identity in 141 aa overlap); etc. X2BKQ1 No conserved hypotheticals Rv2311 NC_002945.3 Mycobrowser_v2 CDS 2562081 2562350 . + 0 Mb2339 HYPOTHETICAL PROTEIN Mb2339, -, len: 89 aa. Equivalent to Rv2312, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Hypothetical unknown protein. X2BK08 No conserved hypotheticals Rv2312 NC_002945.3 Mycobrowser_v2 CDS 2563512 2564885 . - 0 Mb2341c conserved protein Mb2341c, -, len: 457 aa. Equivalent to Rv2314c,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 457 aa overlap). Conserved hypothetical protein, highly similar to Q9RJ51|SCI8.02 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (464 aa) FASTA scores: opt: 1485, E(): 5.2e-83, (53.5% identity in 454 aa overlap); similar to AAK24788|CC2824 TldD/PmbA family protein from Caulobacter crescentus (441 aa), FASTA scores: opt: 364, E(): 8.3e-15, (29.8% identity in 460 aa overlap); and showing similarity with Q9HJZ6|TA0814 HYPOTHETICAL PROTEIN from Thermoplasma acidophilum (430 aa), FASTA scores: opt: 220, E(): 4.7e-06, (21.85% identity in 348 aa overlap). Q7TYU5 No conserved hypotheticals Rv2314c NC_002945.3 Mycobrowser_v2 CDS 2581290 2581817 . - 0 Mb2357c lppP PROBABLE LIPOPROTEIN LPPP Mb2357c, lppP, len: 175 aa. Equivalent to Rv2330c,len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. X2BKC1,P65303 No NC_002945.3 Mycobrowser_v2 CDS 2564882 2566399 . - 0 Mb2342c conserved protein Mb2342c, -, len: 515 aa. Equivalent to Rv2315c,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 505 aa overlap). Conserved hypothetical protein, highly similar to Q9S273|SCI28.10 HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (435 aa), FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46, (42.8% identity in 505 overlap); O58578|PH0848 HYPOTHETICAL 54.4 KDA PROTEIN from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661,E(): 4.3e-33, (29.95% identity in 484 aa overlap); Q9UZ95|PAB1547 HYPOTHETICAL 53.6 KDA PROTEIN from Pyrococcus abyssi (473 aa), FASTA scores: opt: 656, E(): 8.6e-33, (29.1% identity in 481 aa overlap); etc. Q7TYU4 No conserved hypotheticals Rv2315c NC_002945.3 Mycobrowser_v2 CDS 2566433 2567305 . + 0 Mb2343 uspA PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPA Mb2343, uspA, len: 290 aa. Equivalent to Rv2316,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 290 aa overlap). Probable uspA,sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN8|USPA|ML1768 SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (328 aa), FASTA scores: opt: 1593,E(): 1.9e-93, (82.35% identity in 289 aa overlap); and similar to O32940|ML1426|MLCB2052.28 POSSIBLE SUGAR TRANSPORT PROTEIN (PROBABLE ABC-TRANSPORT PROTEIN, INNER MEMBRANE COMPONENT) from Mycobacterium leprae (319 aa),FASTA scores: opt: 600, E(): 9.2e-31, (34.25% identity in 295 aa overlap). Also similar to other proteins involved in transport e.g. Q9X860|SCE134.05c PUTATIVE BINDING PROTEIN DEPENDENT TRANSPORT PROTEIN from Streptomyces coelicolor (327 aa), FASTA scores: opt: 639, E(): 3.2e-33,(40.45% identity in 272 aa overlap); Q9K6N9|BH3689 SUGAR TRANSPORT SYSTEM (PERMEASE) from Bacillus halodurans (300 aa), FASTA scores: opt: 590, E(): 3.7e-30, (35.65% identity in 289 aa overlap); etc. Q7TYU3 No cell wall and cell processes Rv2316 NC_002945.3 Mycobrowser_v2 CDS 2572294 2572959 . - 0 Mb2349c rocD1 PROBABLE ORNITHINE AMINOTRANSFERASE (N-terminus part) ROCD1 (ORNITHINE--OXO-ACID AMINOTRANSFERASE) Mb2349c, rocD1, len: 221 aa. Equivalent to Rv2322c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable rocD1,ornithine aminotransferase (EC: 2.6.1.13), highly similar to N-terminal region of other ornithine aminotransferases,e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa),FASTA scores: opt: 770, E(): 8.7e-40, (55.7% identity in 201 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa) FASTA scores: opt: 632,E(): 2.2e-31, (46.1% identity in 208 aa overlap); P38021|OAT_BACSU|ROCD from Bacillus subtilis (401 aa),FASTA scores: opt: 626, E(): 5.1e-31, (43.1% identity in 218 aa overlap); etc. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Rv2322c|MTCY3G12.12 and Rv2321c|MTCY3G12.13 (upstream ORF) appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this. Q7TYT8 No NC_002945.3 Mycobrowser_v2 CDS 2567292 2568116 . + 0 Mb2344 uspB PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPB Mb2344, uspB, len: 274 aa. Equivalent to Rv2317,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Probable uspB,sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN7|USPE|ML1769 SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (274 aa), FASTA scores: opt: 1522,E(): 3.4e-89, (85.0% identity in 274 aa overlap); and similar to O32941|ML1425|MLCB2052.29 PROBABLE ABC-TRANSPORT PROTEIN, INNER MEMBRANE COMPONENT from Mycobacterium leprae (283 aa), FASTA scores: opt: 630,E(): 8.4e-33, (36.55% identity in 268 aa overlap). Also similar to other integral membrane proteins e.g. P73854|LACG|SLR1723 LACTOSE TRANSPORT SYSTEM PERMEASE PROTEIN from Synechocystis sp. strain PCC 6803 (270 aa),FASTA scores: opt: 605, E(): 3.1e-31, (36.0% identity in 264 aa overlap); Q9F3B8|SC5F1.11 PUTATIVE SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (307 aa), FASTA scores: opt: 582, E(): 9.7e-30, (34.45% identity in 264 aa overlap); etc. Also similar to O53483|Rv2039c|MTV018.26c SUGAR TRANSPORT PROTEIN from Mycobacterium tuberculosis (280 aa), FASTA scores: opt: 630, E(): 8.3e-89, (37.7% identity in 268 aa overlap). Q7TYU2 No cell wall and cell processes Rv2317 NC_002945.3 Mycobrowser_v2 CDS 2568113 2569435 . + 0 Mb2345 uspC PROBABLE PERIPLASMIC SUGAR-BINDING LIPOPROTEIN USPC Mb2345, uspC, len: 440 aa. Equivalent to Rv2318,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 440 aa overlap). Probable uspC,sugar-binding lipoprotein component of sugar transport system (see citation below), most similar to Q9CBN6|USPC|ML1770 SUGAR TRANSPORT PERIPLASMIC BINDING PROTEIN from Mycobacterium leprae (446 aa), FASTA scores: opt: 2294, E(): 8.1e-135, (74.7% identity in 446 aa overlap). Also similar to other substrate-binding proteins e.g. Q9RK89|SCF1.15 PUTATIVE SUBSTRATE BINDING PROTEIN (EXTRACELLULAR) (BINDING-PROTEIN-DEPENDENT TRANSPORT) (FRAGMENT) from Streptomyces coelicolor (221 aa), FASTA scores: opt: 377, E(): 3e-16, (32.25% identity in 217 aa overlap); Q9K6N8|BH3690 SUGAR TRANSPORT SYSTEM (SUGAR-BINDING PROTEIN) from Bacillus halodurans (420 aa),FASTA scores: opt: 227, E(): 1e-06, (25.00% identity in 452 aa overlap); etc. Also similar to O53485|Rv2041c|MTV018.28C LIPOPROTEIN COMPONENT OF SUGAR TRANSPORT SYSTEM from Mycobacterium tuberculosis (439 aa),FASTA scores: opt: 246, E(): 7e-08, (26.75% identity in 325 aa overlap). Contains a hydrophobic stretch (possible signal peptide) at N-terminal end. Q7TYU1 No cell wall and cell processes Rv2318 NC_002945.3 Mycobrowser_v2 CDS 2570318 2571748 . - 0 Mb2347c rocE PROBABLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN ROCE Mb2347c, rocE, len: 476 aa. Equivalent to Rv2320c,len: 476 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 476 aa overlap). Probable rocE,cationic amino acid (especially arginine and ornithine) transporter (permease), highly similar to other amino acid transporters e.g. Q9L100|SCL6.16C PUTATIVE AMINO ACID TRANSPORTER from Streptomyces coelicolor (496 aa), FASTA scores: opt: 1485, E(): 9.4e-82, (48.4% identity in 477 aa overlap); O06479|YFNA PUTATIVE AMINO ACID TRANSPORTER from Bacillus subtilis (462 aa), FASTA scores: opt: 1271, E(): 6.1e-69, (41.9% identity in 463 aa overlap); Q9PG94|XF0408 AMINO ACID TRANSPORTER from Xylella fastidiosa (509 aa),FASTA scores: opt: 1128, E(): 2.5e-60, (39.5% identity in 481 aa overlap); etc. Also some similarity with Z99108.1|BSUB0005 from Bacillus subtilis (461 aa), FASTA scores: opt: 1271, E(): 0, (41.9% identity in 463 aa overlap); and G403170 ETHANOLAMINE PERMEASE (488 aa),FASTA scores: opt: 468, E(): 1e-23, (28.1% identity in 462 aa overlap). SEEMS TO BELONG TO THE APC FAMILY. Q7TYU0 No NC_002945.3 Mycobrowser_v2 CDS 2571749 2572294 . - 0 Mb2348c rocD2 PROBABLE ORNITHINE AMINOTRANSFERASE (C-terminus part) ROCD2 (ORNITHINE--OXO-ACID AMINOTRANSFERASE) Mb2348c, rocD2, len: 181 aa. Equivalent to Rv2321c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Probable rocD2,ornithine aminotransferase (EC: 2.6.1.13), highly similar to C-terminal region of other ornithine aminotransferases,e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa),FASTA scores: opt: 628, E(): 1.2e-32, (55.35% identity in 168 aa overlap); P3802|OAT_BACSU|ROCD from Bacillus subtilis (401 aa), FASTA scores: opt: 477, E(): 4.3e-23,(42.1% identity in 178 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa),FASTA scores: opt: 437, E(): 1.5e-20, (41.3% identity in 170 aa overlap); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Rv2322c|MTCY3G12.12 (upstream ORF) and Rv2321c|MTCY3G12.13 appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this. Q7TYT9 No NC_002945.3 Mycobrowser_v2 CDS 2572956 2573864 . - 0 Mb2350c conserved protein Mb2350c, -, len: 302 aa. Equivalent to Rv2323c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Conserved hypothetical protein, highly similar to others eg Q9FC91|2SCG58.22 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (288 aa), FASTA scores: opt: 561, E(): 7.3e-28,(46.95% identity in 279 aa overlap); P74535|SLL1336 HYPOTHETICAL 78.3 KDA PROTEIN from Synechocystis sp. (705 aa), FASTA scores: opt: 555, E(): 2.1e-27, (37.75% identity in 265 aa overlap); etc. Also similar to various hydrolases e.g. Q53797 BETA-HYDROXYLASE (BLEOMYCIN/PHLEOMYCIN BINDING PROTEIN, ANKYRIN HOMOLOGUE,BLEOMYCIN AND TRANSPORT PROTEIN) from Streptomyces verticillus (326 aa), FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in 303 aa overlap); Q9X7M4|DDAH_STRCO|SC5F2A.01c NG,NG-dimethylarginine dimethylaminohydrolase (EC 3.5.3.18) (Dimethylargininase) (Dimethylarginine dimethylaminohydrolase) (258 aa), FASTA scores: opt: 209, E(): 4.9e-06, (27.15% identity in 243 aa overlap); G434715 beta-hydroxylase (bleomicin/phleomycin binding protein) from Streptomyces verticillus (326 aa),FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in 303 aa overlap); etc. Q7TYT7 No conserved hypotheticals Rv2323c NC_002945.3 Mycobrowser_v2 CDS 2573929 2574375 . + 0 Mb2351 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY) Mb2351, -, len: 148 aa. Equivalent to Rv2324, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Probable transcriptional regulatory protein, asnC-family, similar to other PUTATIVE ASNC-FAMILY REGULATORY PROTEINS e.g. Q9L101|SCL6.15C from Streptomyces coelicolor (150 aa) FASTA scores: opt: 466, E(): 2.4e-24, (52.8% identity in 142 aa overlap); Q9RKY4|SC6D7.14 PUTATIVE ASNC-FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (165 aa), FASTA scores: opt: 266, E(): 5.5e-11,(32.4% identity in 145 aa overlap); Q9ZEP1|LRPA|SCE94.12c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (150 aa), FASTA scores: opt: 249, E(): 6.9e-10,(33.35% identity in 147 aa overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (150 aa), FASTA scores: opt: 261, E(): 1.1e-10, (36.4% identity in 143 aa overlap). Q7TYT6 No regulatory proteins Rv2324 NC_002945.3 Mycobrowser_v2 CDS 2581892 2582278 . + 0 Mb2358 HYPOTHETICAL PROTEIN Mb2358, -, len: 128 aa. Equivalent to Rv2331, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04. X2BKR9 No conserved hypotheticals Rv2331 NC_002945.3 Mycobrowser_v2 CDS 2582335 2582673 . + 0 Mb2359 HYPOTHETICAL PROTEIN Mb2359, -, len: 112 aa. Equivalent to Rv2331A, len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 112 aa overlap). Hypothetical unknown protein. Q7TYT3 No conserved hypotheticals Rv2331A NC_002945.3 Mycobrowser_v2 CDS 2574604 2575452 . - 0 Mb2352c CONSERVED HYPOTHETICAL PROTEIN Mb2352c, -, len: 282 aa. Equivalent to Rv2325c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 282 aa overlap). Conserved hypothetical protein, equivalent to O32970|MLCB22.37c|ML0849 hypothetical protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1405,E(): 1.8e-78, (77.7% identity in 282 aa overlap). Also some similarity to other proteins e.g. Q9Z9J1|YBAF|BH0166 YBAF PROTEIN (BH0166 PROTEIN) (HYPOTHETICAL PROTEIN) from Bacillus halodurans (265 aa), FASTA scores: opt: 288, E(): 2.8e-10, (25.8% identity in 264 aa overlap); P70972|YBAF YBAF PROTEIN (HYPOTHETICAL PROTEIN) from Bacillus subtilis (265 aa), FASTA scores: opt: 259, E(): 1.5e-08, (25.45% identity in 224 aa overlap); AAK34821|SPY2193|Q99X13 Conserved hypothetical protein from Streptococcus pyogenes (266 aa), FASTA scores: opt: 232, E(): 6.5e-07, (25.1% identity in 267 aa overlap); etc. X2BKB6,P64998 No conserved hypotheticals Rv2325c NC_002945.3 Mycobrowser_v2 CDS 2575449 2577542 . - 0 Mb2353c possible transmembrane atp-binding protein abc transporter Mb2353c, -, len: 697 aa. Equivalent to Rv2326c,len: 697 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 697 aa overlap). Putative transmembrane ATP-binding protein ABC transporter (see citation below). Equivalent to Q9CCF9|ML0848 ABC TRANSPORTER from Mycobacterium leprae (724 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap) and also to O32971|MLCB22.38c ABC-TYPE TRANSPORTER from Mycobacterium leprae (726 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap). Similar in part to other ABC TRANSPORTERS e.g. Q9WY65|TM0222 from Thermotoga maritima (266 aa),FASTA scores: opt: 407, E(): 4.2e-15, (38.0% identity in 213 aa overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop); and 2 x PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BKR5,P63400 No cell wall and cell processes Rv2326c NC_002945.3 Mycobrowser_v2 CDS 2610221 2610649 . - 0 Mb2381c unknown protein Mb2381c, -, len: 142 aa. Equivalent to Rv2360c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Hypothetical unknown protein. Q7TYR5 No conserved hypotheticals Rv2360c NC_002945.3 Mycobrowser_v2 CDS 2577583 2578074 . + 0 Mb2354 conserved protein Mb2354, -, len: 163 aa. Equivalent to Rv2327, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to Z80775|MTCY21D4.05c|Rv0042c from Mycobacterium tuberculosis (208 aa), FASTA scores: opt: 242, E(): 5e-08,(43.0% identity in 107 aa overlap). Also slight similarity to putative transcriptional regulatory proteins belonging to the MARR-FAMILY e.g. Q9CCY2/ML2696 from Mycobacterium leprae (243 aa), FASTA scores: opt: 245, E(): 3.7e-08,(35.35% identity in 150 aa overlap); Q9L135|SC6D11.20 from Streptomyces coelicolor (155 aa), FASTA scores: opt: 242,E(): 3.9e-08, (34.75% identity in 141 aa overlap); etc. Q7TYT5 No conserved hypotheticals Rv2327 NC_002945.3 Mycobrowser_v2 CDS 2578326 2579474 . + 0 Mb2355 PE23 pe family protein pe23 Mb2355, PE23, len: 382 aa. Equivalent to Rv2328,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 382 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS HOMOLOG from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18,(34.65% identity in 401 aa overlap); etc. X2BKT3,P0A685 No PE/PPE Rv2328 NC_002945.3 Mycobrowser_v2 CDS 2579509 2581056 . - 0 Mb2356c narK1 PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK1 (NITRITE FACILITATOR 1) Mb2356c, narK1, len: 515 aa. Equivalent to Rv2329c,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 515 aa overlap). Probable narK1,nitrite extrusion protein, possibly member of major facilitator superfamily (MFS). Equivalent to O32974|MLCB22.41c|NARK|ML0844 PUTATIVE NITRITE EXTRUSION PROTEIN from Mycobacterium leprae (517 aa), FASTA scores: opt: 2224, E(): 1.9e-129, (69.3% identity in 488 aa overlap). Also highly similar to others e.g. P94933 NITRITE EXTRUSION PROTEIN from Mycobacterium fortuitum (471 aa), FASTA scores: opt: 1969, E(): 8.6e-114, (62.1% identity in 459 aa overlap); P37758|NARU_ECOLI NITRITE EXTRUSION PROTEIN 2 from Escherichia coli strain K12 (462 aa), FASTA scores: opt: 792, E(): 2.3e-41, (36.95% identity in 476 aa overlap); P10903|NARK_ECOLI nitrite extrusion protein (nitrite facilitator 1) from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 784, E(): 7e-41, (35.3% identity in 468 aa overlap); etc. Also similar to RV0261c|Z86089|MTCY6A4_5 from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 2000, E(): 1.1e-115, (62.6% identity in 470 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS. Q7TYT4 No NC_002945.3 Mycobrowser_v2 CDS 2582703 2584349 . + 0 Mb2360 mez PROBABLE [NAD] DEPENDENT MALATE OXIDOREDUCTASE MEZ (MALIC ENZYME) (NAD-MALIC ENZYME) (MALATE DEHYDROGENASE (OXALOACETATE DECARBOXYLATING)) (PYRUVIC-MALIC CARBOXYLASE) (NAD-ME) Mb2360, mez, len: 548 aa. Equivalent to Rv2332,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 548 aa overlap). Probable mez, malate oxidoreductase [NAD] dependant (EC 1.1.1.38) (malic enzyme), highly similar to others e.g. O34389|MALS PUTATIVE MALOLACTIC ENZYME [INCLUDES: MALIC ENZYME (EC 1.1.1.-); L-LACTATE DEHYDROGENASE (EC 1.1.1.27)] from Bacillus subtilis (566 aa), FASTA scores: opt: 1927, E(): 5.5e-111, (52.9% identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA PROBABLE NAD-DEPENDENT MALIC ENZYME from Bacillus subtilis (582 aa), FASTA scores: opt: 1849,E(): 3.6e-106, (50.45% identity in 543 aa overlap); Q48796|MLES_OENOE MALOLACTIC ENZYME from Oenococcus oeni (541 aa), FASTA scores: opt: 1540, E(): 3.6e-87, (44.2% identity in 536 aa overlap); etc. BELONGS TO THE MALIC ENZYMES FAMILY. N-terminus shortened since first submission (previously 652 aa). Q7TYT2 No intermediary metabolism and respiration Rv2332 NC_002945.3 Mycobrowser_v2 CDS 2584346 2585917 . - 0 Mb2361c stp integral membrane drug efflux protein stp Mb2361c, -, len: 523 aa. Equivalent to Rv2333c,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 508 aa overlap). Probable conserved integral membrane transport protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug, highly similar to many e.g. Q9RL22|C5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 1031,E(): 4e-55, (37.4% identity in 412 aa overlap); Q9L0L9|SCD82.12 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (490 aa), FASTA scores: opt: 883,E(): 3.8e-46, (36.35% identity in 407 aa overlap); Q9ZBW5|SC4B5.03c PUTATIVE INTEGRAL MEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (504 aa), FASTA scores: opt: 899, E(): 4.1e-47, (37.4% identity in 415 aa overlap); P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa), FASTA scores: opt: 839, E(): 1.9e-43, (32.3% identity in 489 aa overlap); etc. Also highly similar to Rv2459|O53186|MTV008.15 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (508 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.05% identity in 504 aa overlap); and AAK46834|MT2534 DRUG TRANSPORTER from Mycobacterium tuberculosis strain CDC1551 (523 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.4% identity in 504 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). Q7TYT1 No cell wall and cell processes Rv2333c NC_002945.3 Mycobrowser_v2 CDS 2838228 2838647 . - 0 Mb2581c CONSERVED HYPOTHETICAL PROTEIN Mb2581c, -, len: 139 aa. Equivalent to Rv2551c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, similar to the second part of Q9XAP1|SC10A7.34c PUTATIVE TYPE IV PEPTIDASE from Streptomyces coelicolor (259 aa), FASTA scores: opt: 243,E(): 7.4e-08, (40.95% identity in 144 aa overlap). Also some similarity with other proteins e.g. AAK58497|GSPO GSPO PROTEIN from Acetobacter diazotrophicus (261 aa),FASTA scores: opt: 152, E(): 0.025, (33.35% identity in 135 aa overlap). Q7TYB4 No conserved hypotheticals Rv2551c NC_002945.3 Mycobrowser_v2 CDS 2586392 2587324 . + 0 Mb2362 cysK1 cysteine synthase a cysk1 (o-acetylserine sulfhydrylase a) (o-acetylserine (thiol)-lyase a) (csase a) Mb2362, cysK1, len: 310 aa. Equivalent to Rv2334,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Probable cysK1,cysteine synthase A (EC 4.2.99.8), equivalent to O32978|CYSK_MYCLE|ML0839|MLCB22.47 CYSTEINE SYNTHASE A from Mycobacterium leprae (310 aa), FASTA scores: opt: 1756, E(): 8.6e-96, (85.8% identity in 310 aa overlap). Also highly similar to other CYSTEINE SYNTHASES e.g. Q9JQL6|CYSK|NMA0974|NMB0763 PUTATIVE CYSTEINE SYNTHASE from Neisseria meningitidis (serogroup A and B) (310 aa),FASTA scores: opt: 1368, E(): 4.6e-73, (66.45% identity in 310 aa overlap); P73410|CYSK_SYNY3|SLR1842 from Synechocystis sp (312 aa), FASTA scores: opt: 1310, E(): 1.2e-69, (64.65% identity in 311 aa overlap); Q43725|CYSM_ARATH|OASC|ACS1|AT3G59760|F24G16.30 CYSTEINE SYNTHASE (MITOCHONDRIAL PRECURSOR) from Arabidopsis thaliana (Mouse-ear cress) (424 aa), FASTA scores: opt: 1253, E(): 3.2e-66, (59.2% identity in 309 aa overlap) (has its N-terminus longer 104 aa); etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Note that previously known as cysK. X2BKC8,P0A535 No NC_002945.3 Mycobrowser_v2 CDS 3093580 3093795 . - 0 Mb2854c vapb22 possible antitoxin vapb22 Mb2854c, -, len: 71 aa. Equivalent to Rv2830c, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 71 aa overlap). Hypothetical protein,some similarity to Z97182|MTCY19H5.26|Rv0596c Hypothetical protein from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 88, E(): 1.3, (41.7% identity in 36 aa overlap); and to PHD_BPP1|Q06253 bacteriophage P1 phd gene (73 aa), FASTA scores: opt: 79, E(): 3.8, (35.9% identity in 39 aa overlap). Q7TXR7 No virulence, detoxification, adaptation Rv2830c NC_002945.3 Mycobrowser_v2 CDS 2587328 2588017 . + 0 Mb2363 cysE PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) Mb2363, -, len: 229 aa. Equivalent to Rv2335, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Probable cysE, serine acetyltransferase (EC 2.3.1.30), equivalent to O32979|CYSE|ML0838 SERINE ACETYLTRANSFERASE from Mycobacterium leprae (227 aa), FASTA scores: opt: 1152,E(): 9.6e-62, (76.4% identity in 229 aa overlap). Also highly similar, except in C-terminal part, to others e.g. Q9HXI6|CYSE|PA3816 O-ACETYLSERINE SYNTHASE from Pseudomonas aeruginosa (258 aa), FASTA scores: opt: 737,E(): 6e-37, (61.3% identity in 168 aa overlap); P23145|NIFP_AZOCH PROBABLE SERINE ACETYLTRANSFERASE from Azotobacter chroococcum mcd 1 (269 aa), FASTA scores: opt: 718, E(): 8.4e-36, (55.45% identity in 220 aa overlap); Q06750|CYSE_BACSU SERINE ACETYLTRANSFERASE from Bacillus subtilis (217 aa), FASTA scores: opt: 640, E(): 3.1e-31,(48.0% identity in 200 aa overlap); etc. Contains PS00101 Bacterial hexapeptide-repeat containing-transferases signature. BELONGS TO THE CYSE/LACA/LPXA/NODL FAMILY OF ACETYLTRANSFERASES. COMPOSED OF MULTIPLE REPEATS OF [LIV]-G-X(4). Q7TYT0 No intermediary metabolism and respiration Rv2335 NC_002945.3 Mycobrowser_v2 CDS 2588433 2589401 . + 0 Mb2364 HYPOTHETICAL PROTEIN Mb2364, -, len: 322 aa. Equivalent to Rv2336, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 322 aa overlap). Hypothetical unknown protein (see second citation below). Q7TYS9 No conserved hypotheticals Rv2336 NC_002945.3 Mycobrowser_v2 CDS 2589465 2590583 . - 0 Mb2365c HYPOTHETICAL PROTEIN Mb2365c, -, len: 372 aa. Equivalent to Rv2337c,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 372 aa overlap). Hypothetical unknown protein, sharing some similarity with Q9RI33|SCJ12.27c HYPOTHETICAL 37.2 KDA PROTEIN from Streptomyces coelicolor (335 aa), BLAST scores: 134 AND 46, (28% AND 33% identity,52% AND 44% positive); FASTA scores: opt: 176, E(): 0.00042, (31.95% identity in 355 aa overlap). Q7TYS8 No conserved hypotheticals Rv2337c NC_002945.3 Mycobrowser_v2 CDS 2590703 2591659 . - 0 Mb2366c moeW POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEW Mb2366c, moeW, len: 318 aa. Equivalent to Rv2338c,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Possible moeW,molybdoptenum biosynthesis protein, showing some similarity to several molybdopterin biosynthesis proteins e.g. O27613|MTH1571 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEB HOMOLOG from Methanobacterium thermoautotrophicum (251 aa), FASTA scores: opt: 309, E(): 4.7e-14; (30.7% identity in 254 aa overlap); Q9KPQ5|VC2311 HESA/MOEB/THIF FAMILY PROTEIN from Vibrio cholerae (273 aa), FASTA scores: opt: 255, E(): 4e-09, (36.25% identity in 149 aa overlap); Q9PD34|XF1545 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Xylella fastidiosa (276 aa), FASTA scores: opt: 233,E(): 1e-07, (33.6% identity in 128 aa overlap); etc. SEEMS TO BELONG TO THE HESA/MOEB/THIF FAMILY. Q7TYS7 No NC_002945.3 Mycobrowser_v2 CDS 2605762 2607606 . - 0 Mb2377c PPE40 ppe family protein ppe40 Mb2377c, PPE40, len: 614 aa. Equivalent to Rv2356c,len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 615 aa overlap). Member of Mycobacterium tuberculosis PPE_family, highly similar to others e.g. Q10778|MTCY48.17|YF48_MYCTU HYPOTHETICAL PPE-FAMILY PROTEIN (678 aa), FASTA scores: opt: 1888, E(): 1.9e-78, (54.4% identity in 667 aa overlap); Q10540|MTCY31.06c, E241779|MTCY98, P42611|MTV037.06c,Q10813|MTCY274.23c, P71657|MTCY02B10.25c, MTCY03C7.23,P71869|MTCY03C7.24c, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (gcg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (614 aa versus 615 aa). Q7TYR8 No NC_002945.3 Mycobrowser_v2 CDS 2597869 2598126 . + 0 Mb2371 CONSERVED HYPOTHETICAL PROTEIN Mb2371, -, len: 85 aa. Equivalent to Rv2342, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, highly similar to Q9CCG1|ML0834 HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 392, E(): 2.9e-20, (78.2% identity in 78 aa overlap). N-terminus highly similar to N-terminal part of Q9L085|SCC24.32 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (108 aa), FASTA scores: opt: 122,E(): 0.077, (39.15% identity in 46 aa overlap). Q7TYS2 No conserved hypotheticals Rv2342 NC_002945.3 Mycobrowser_v2 CDS 2592290 2594770 . + 0 Mb2367 mmpL9a PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL9A [FIRST PART] Mb2367, mmpL9a, len: 826 aa. Equivalent to 5' end of Rv2339, len: 962 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 826 aa overlap). Probable mmpL9, conserved transmembrane transport protein (see citation below), with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity in 937 aa overlap); G699237|U1740AB from Mycobacterium leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from M. tuberculosis. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, truncation due to a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b, resulting in a shorter mmpL9a product. Q7TYS6 No NC_002945.3 Mycobrowser_v2 CDS 2595264 2596505 . - 0 Mb2369c PE_PGRS39 pe-pgrs family protein pe_pgrs39 Mb2369c, PE_PGRS39, len: 413 aa. Equivalent to Rv2340c, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 413 aa overlap). Member of the Mycobacterium tuberculosis PE_family, PGRS subfamily of gly-rich proteins, similar to others eg YI18_MYCTU|Q50615|Rv1818c|MTCY1A11.25 PE-PGRS FAMILY PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 710, E(): 1.4e-22, (41.0% identity in 368 aa overlap); O53884|Rv0872v|MTV043.65c PGRS-FAMILY PROTEIN from Mycobacterium tuberculosis (606 aa), FASTA scores: opt: 708, E(): 1.9e-22, (42.4% identity in 389 aa overlap); etc. Q7TYS4 No NC_002945.3 Mycobrowser_v2 CDS 2597194 2597613 . + 0 Mb2370 lppQ PROBABLE CONSERVED LIPOPROTEIN LPPQ Mb2370, lppQ, len: 139 aa. Equivalent to Rv2341,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable lppQ,conserved lipoprotein, showing some similarity with Rv1228|O33224|LPQX|MTCI61.11 from Mycobacterium tuberculosis (185 aa), FASTA scores: opt: 155; E(): 0.0073; (31.9% identity in 116 aa overlap). Also shows few similarity with P29228|VLPA_MYCHR variant surface antigen A precursor from Mycoplasma hyorhinis (157 aa), FASTA scores: opt: 96, E(): 7.3, (23.1% identity in 143 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TYS3 No cell wall and cell processes Rv2341 NC_002945.3 Mycobrowser_v2 CDS 2611532 2612329 . - 0 Mb2383c reco possible dna repair protein reco Mb2383c, -, len: 265 aa. Equivalent to Rv2362c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Conserved hypothetical protein, equivalent to the Mycobacterium leprae proteins Q49754|B1937_F1_25 Hypothetical protein (269 aa), FASTA scores: opt: 1561, E(): 8.5e-93, (86.6% identity in 268 aa overlap); and Q9CCN0|ML0633 Hypothetical protein (268 aa), FASTA scores: opt: 1560,E(): 8.5e-93, (86.6% identity in 268 aa overlap). Also highly similar to Q9L2H3|SCC121.13c HYPOTHETICAL 27.1 KDA PROTEIN from Streptomyces coelicolor (251 aa), FASTA scores: opt: 843, E(): 6.9e-47, (52.2% identity in 249 aa overlap); ans similar to other hypothetical proteins. Weak similarity with P42095|RECO_BACSU DNA REPAIR PROTEIN RECOMBINASE from Bacillus subtilis (255 aa), FASTA scores: opt: 270, E(): 3.6e-10, (26.4% identity in 182 aa overlap). X2BKV0,P65984 No information pathways Rv2362c NC_002945.3 Mycobrowser_v2 CDS 2598130 2600049 . - 0 Mb2372c dnaG PROBABLE DNA PRIMASE DNAG Mb2372c, dnaG, len: 639 aa. Equivalent to Rv2343c,len: 639 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 639 aa overlap). Probable dnaG, DNA primase (EC 2.7.7.-), equivalent to O52200|PRIM_MYCSM|DNAG DNA PRIMASE from Mycobacterium smegmatis (636 aa), FASTA scores: opt: 3504, E(): 5.5e-202, (81.55% identity in 639 aa overlap); and Q9CCG2|DNAG|ML0833 DNA PRIMASE from Mycobacterium leprae (642 aa), FASTA scores: opt: 3443,E(): 2.5e-198, (80.4% identity in 642 aa overlap). Also highly similar to many DNA primases e.g. Q9S1N4|PRIM_STRCO|DNAG|SC7A8.07c from Streptomyces coelicolor (641 aa), FASTA scores: opt: 1899, E(): 5.1e-106, (47.9% identity in 643 aa overlap); P74893|PRIM_SYNP7|DNAG from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (616 aa), FASTA scores: opt: 860, E(): 6.6e-44, (35.3% identity in 513 aa overlap); P05096|PRIM_BACSU from Bacillus subtilis (603 aa) FASTA scores: opt: 800, E(): 2.5e-40, (33.7% identity in 430 aa overlap); etc. X2BKE2,P63963 No NC_002945.3 Mycobrowser_v2 CDS 4171669 4172034 . + 0 Mb3818 gtra family protein Mb3818, -, len: 121 aa. Equivalent to Rv3789, len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 121 aa overlap). Conserved hypothetical protein, equivalent to Q9CDA3|ML0110 HYPOTHETICAL 13.9 KDA PROTEIN from Mycobacterium leprae (123 aa) FASTA scores: opt: 587, E(): 7.3e-34, (72.95% identity in 122 aa overlap). Equivalent to AAK48262 from Mycobacterium tuberculosis strain CDC1551 (142 aa) but shorter 21 aa. X2BPU5,P64293 No cell wall and cell processes Rv3789 NC_002945.3 Mycobrowser_v2 CDS 2600054 2601349 . - 0 Mb2373c dgt PROBABLE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DGT (DGTPASE) (DGTP TRIPHOSPHOHYDROLASE) Mb2373c, dgt, len: 431 aa. Equivalent to Rv2344c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). Probable dgt,deoxyguanosine triphosphate triphosphohydrolase (EC 3.1.5.1), equivalent to Q9CCG3|DGT|ML0831 PUTATIVE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 2316,E(): 1.6e-137, (83.85% identity in 421 aa overlap); and O52199|DGTP_MYCSM|AF027507_2 DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium smegmatis (428 aa),FASTA scores: opt: 1991, E(): 3.4e-117, (73.5% identity in 422 aa overlap). Also highly similar or similar to several deoxyguanosine triphosphate hydrolases e.g. Q9L2E9|SC7A8.09c PUTATIVE DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Streptomyces coelicolor (424 aa),FASTA scores: opt: 1216, E(): 1e-68, (51.05% identity in 425 aa overlap); BAB48544|MLL1093 DGTP TRIPHOSPHOHYDROLASE from Rhizobium loti (Mesorhizobium loti) (404 aa), FASTA scores: opt: 489, E(): 3.1e-23, (33.85% identity in 387 aa overlap); P15723|DGTP_ECOLI|DGT|B0160 from Escherichia coli strain K12 (504 aa), FASTA scores: opt: 173, E(): 0.0022, (31.65% identity in 259 aa overlap); etc. BELONGS TO THE DGTPASE FAMILY. X2BKT4,P0A541 No NC_002945.3 Mycobrowser_v2 CDS 2601418 2603400 . + 0 Mb2374 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb2374, -, len: 660 aa. Equivalent to Rv2345, len: 660 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 660 aa overlap). Possible conserved transmembrane protein, with hydrophobic stretch at N-terminal end around position 180. Similar to O52198 HYPOTHETICAL 21.2 KDA PROTEIN (FRAGMENT) from Mycobacterium smegmatis (195 aa), FASTA scores: opt: 589,E(): 1.5e-23; (47.2% identity in 195 aa overlap). Q7TYS1 No cell wall and cell processes Rv2345 NC_002945.3 Mycobrowser_v2 CDS 2613842 2614744 . - 0 Mb2385c era PROBABLE GTP-BINDING PROTEIN ERA Mb2385c, era, len: 300 aa. Equivalent to Rv2364c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable era,GTP-binding protein, equivalent to Q49768|ERA_MYCLE|ML0631|B1937_F3_102 GTP-BINDING PROTEIN ERA HOMOLOG from Mycobacterium leprae (300 aa) FASTA scores: opt: 1589, E(): 3.4e-88, (81.4% identity in 301 aa overlap). Also highly similar to other GTP-binding proteins e.g. Q9RDF2|ERA_STRCO|SCC77.06 from Streptomyces coelicolor (317 aa), FASTA scores: opt: 1264, E(): 1.1e-68, (64.0% identity in 306 aa overlap); Q9KD52|ERA_BACHD|BH1367|BEX from Bacillus halodurans (304 aa), FASTA scores: opt: 869, (44.8% identity in 297 aa overlap); Q9KIH7|ERA_LACLA|ERAL from Lactococcus lactis (subsp. lactis) (Streptococcus lactis), and Lactococcus lactis (subsp. cremoris) (Streptococcus cremoris) (303 aa), FASTA scores: opt: 781, E(): 9.4e-40, (40.25% identity in 298 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ERA/TRME FAMILY OF GTP-BINDING PROTEINS, ERA SUBFAMILY. Note that previously known as bex. X2BKV8,P0A563 No NC_002945.3 Mycobrowser_v2 CDS 2603485 2603667 . - 0 Mb2375c esxO putative esat-6 like protein esxo (esat-6 like protein 6) Mb2375c, esxO, len: 60 aa. Equivalent to 3' end of Rv2346c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 60 aa overlap). esxO,putative ESAT-6 like protein 6, conserved hypotheticalprotein, member of proteins family from Mycobacterium tuberculosis, with O53942|Rv1793|MTV049.15,O05300|Rv1198|MTCI364.10, MTCY15C10.33,P96364|MTCY07H7B.03|Rv1037c|MTCY10G2.12, MTCI364.10, etc. BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Mb2375c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv. Q7TYS0 No NC_002945.3 Mycobrowser_v2 CDS 2610649 2611539 . - 0 Mb2382c LONG (C50) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-DECAPRENYL DIPHOSPHATE SYNTHASE) Mb2382c, -, len: 296 aa. Equivalent to Rv2361c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Long (C50) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.-) (see citation below), equivalent to UPPS_MYCLE|ML0634|B1937_F2_65|P38119 UNDECAPRENYL PYROPHOSPHATE SYNTHETASE from Mycobacterium leprae (296 aa), FASTA scores: opt: 1789, E(): 1.8e-97, (86.5% identity in 296 aa overlap). Also highly similar to others e.g. UPPS|Q9L2H4 UNDECAPRENYL PYROPHOSPHATE SYNTHETASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 1098, E(): 8.2e-60, (63.5% identity in 247 aa overlap); Q55482|UPPS_SYNY3|SLL0506 from Synechocystis sp. strain PCC 6803 (249 aa), FASTA scores: opt: 686, E(): 4.2e-33,(46.4% identity in 235 aa overlap); O67291|UPPS_AQUAE|AQ_1248 from Aquifex aeolicus (231 aa),FASTA scores: opt: 684, E(): 5.2e-33, (46.3% identity in 229 aa overlap); etc. Also similar to Rv1086|MTV017.39 from Mycobacterium tuberculosis. Contains PS01066 Hypothetical YBR002c family signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY. Note that previously known as uppS. X2BKF4,P60478 No cell wall and cell processes Rv2361c NC_002945.3 Mycobrowser_v2 CDS 2603651 2605024 . - 0 Mb2376c PPE71 PPE FAMILY PROTEIN Mb2376c, PPE71, len: 457 aa. Equivalent to 5' end of MT2423, len: 621 aa, from Mycobacterium tuberculosis strain CDC1551, (98.475% identity in 459 aa overlap). PPE FAMILY PROTEIN. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, there is a large 8963 bp deletion (RD5) in between Mb2375c and Mb2377c compared to Mycobacterium tuberculosis strain H37Rv. In this region of Mycobacterium bovis two substitutions are present that encode a CDS, Mb2376c, equivalent to that found in Mycobacterium tuberculosis strain CDC1551. The first substitution is of 1218 bp to 350 bp and the second is of 123 bp to 431 bp. Q7TYR9 No NC_002945.3 Mycobrowser_v2 CDS 2844524 2845198 . + 0 Mb2587 conserved protein Mb2587, -, len: 224 aa. Equivalent to Rv2557, len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Conserved hypothetical protein, highly similar only to upstream ORF Q50740|MTCY9C4.10c|Rv2558|MT2635 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (236 aa), FASTA scores: opt: 1007, E(): 6.9e-60, (69.2% identity in 224 aa overlap). X2BLP8 No conserved hypotheticals Rv2557 NC_002945.3 Mycobrowser_v2 CDS 2607744 2609135 . - 0 Mb2378c glyS PROBABLE GLYCYL-tRNA SYNTHETASE GLYS (GLYCINE--tRNA LIGASE) (GLYRS) Mb2378c, glyS, len: 463 aa. Equivalent to Rv2357c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Probable glyS,glycyl-tRNA synthetase (EC 6.1.1.14), equivalent to Q9CCG4|GLYS|ML0826 PUTATIVE GLYCYL-TRNA SYNTHASE from Mycobacterium leprae (463 aa), FASTA scores: opt: 2898,E(): 1e-179, (90.2% identity in 459 aa overlap). Also highly similar to others e.g. Q9L2H9|SYG_STRCO|SCC121.07c from Streptomyces coelicolor (460 aa), FASTA scores: opt: 2210, E(): 2.9e-135, (68.3% identity in 457 aa overlap); Q9PPZ7|SYG_UREPA|GLYS|UU493 GLYCYL-TRNA SYNTHETASE from Ureaplasma parvum (Ureaplasma urealyticum biotype 1) (473 aa), FASTA scores: opt: 1254, E(): 1.7e-73, (45.25% identity in 462 aa overlap); P75425|SYG_MYCPN|GLYS|MPN354|MP482 GLYCYL-TRNA SYNTHETASE from Mycoplasma pneumoniae (449 aa), FASTA scores: opt: 1074, E(): 6.9e-62, (39.45% identity in 454 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. X2BKU2,P67033 No NC_002945.3 Mycobrowser_v2 CDS 2609317 2609724 . + 0 Mb2379 smtb probable transcriptional regulatory protein smtb (probably arsr-family) Mb2379, -, len: 135 aa. Equivalent to Rv2358, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Probable transcriptional regulator, arsR family, equivalent to Q9CCG5|ML0825 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (140 aa), FASTA scores: opt: 647, E(): 2e-34, (72.9% identity in 140 aa overlap). Also similar to others e.g. BAB48273|MLR0745 Transcriptional regulator from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 185,E(): 3.4e-05, (43.25% identity in 74 aa overlap) (has its N-terminus shorter); P15905|ARR1_ECOLI arsenical resistance operon repressor from Escherichia coli (117 aa), FASTA scores: opt: 164, E(): 8.1e-05, (39.1% identity in 69 aa overlap); etc. Also similar to O53838|Rv0827|MTV043.19c PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 201, E(): 4e-06, (35.7% identity in 98 aa overlap); and O69711|Rv3744|MTV025.092 PUTATIVE REGULATORY PROTEIN from Mycobacterium tuberculosis (120 aa), FASTA scores: opt: 209, E(): 1.2e-06, (35.5 % identity in 93 aa overlap). Contains possible helix-turn-helix motif at aa 72-93 (Score 1103, +2.94 SD). Belongs to the ARSR family of transciptional regulators. Q7TYR7 No regulatory proteins Rv2358 NC_002945.3 Mycobrowser_v2 CDS 2609721 2610113 . + 0 Mb2380 zur probable zinc uptake regulation protein zur Mb2380, furB, len: 130 aa. Equivalent to Rv2359,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 130 aa overlap). Probable furB, ferric uptake regulation protein, equivalent to FURB|ML0824|Q9CCG6 PUTATIVE FERRIC UPTAKE REGULATORY PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: opt: 765, E(): 1.7e-43, (86.9% identity in 130 aa overlap). Also highly similar to FERRIC UPTAKE REGULATION PROTEINS e.g. Q9L2H5|SCC121.11 PUTATIVE METAL UPTAKE REGULATION PROTEIN from Streptomyces coelicolor (139 aa),FASTA scores: opt: 547, E(): 3.4e-29, (59.4% identity in 133 aa overlap); P06975|FUR_ECOLI from Escherichia coli (148 aa), FASTA scores: opt: 322, E(): 1.9e-14, (37.9% identity in 132 aa overlap); P45599|FUR_KLEPN FERRIC UPTAKE REGULATION PROTEIN from Klebsiella pneumoniae (155 aa), FASTA scores: opt: 314, E(): 6.7e-14, (36.35% identity in 132 aa overlap); etc. BELONGS TO THE FUR FAMILY. Q7TYR6 No regulatory proteins Rv2359 NC_002945.3 Mycobrowser_v2 CDS 2685981 2686361 . - 0 Mb2443c CONSERVED HYPOTHETICAL PROTEIN Mb2443c, -, len: 126 aa. Equivalent to Rv2420c,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Conserved hypothetical protein, equivalent to Q9CBZ9|ML1453 HYPOTHETICAL PROTEIN from Mycobacterium leprae (129 aa),FASTA scores: opt: 681, E(): 1.6e-38, (87.0% identity in 123 aa overlap). Also highly similar to Q9RDK9|SCC123.15c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (148 aa), FASTA scores: opt: 447, E(): 5.8e-23, (52.7% identity in 129 aa overlap); and similar to others e.g. P54457|YQEL_BACSU HYPOTHETICAL PROTEIN from Bacillus subtilis (118 aa), FASTA scores: opt: 318, E(): 1.8e-14,(37.3% identity in 110 aa overlap); Q9KD89|BH1328 HYPOTHETICAL PROTEIN from Bacillus halodurans (117 aa),FASTA scores: opt: 296, E(): 5.1e-13, (37.6% identity in 109 aa overlap); etc. Q7TYM2 No conserved hypotheticals Rv2420c NC_002945.3 Mycobrowser_v2 CDS 2612391 2613845 . + 0 Mb2384 amiA2 PROBABLE AMIDASE AMIA2 (AMINOHYDROLASE) Mb2384, amiA2, len: 484 aa. Equivalent to Rv2363,len: 484 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 484 aa overlap). Probable amiA2,amidase (EC 3.5.1.4), highly similar or similar to others e.g. O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 777,E(): 1.1e-38, (35.0% identity in 474 aa overlap); Q55424|AMID_SYNY3|SLL0828 PUTATIVE AMIDASE from Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores: opt: 770, E(): 3e-38, (36.4% identity in 456 aa overlap); Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from Rhodococcus sp. (462 aa), FASTA scores: opt: 701, E(): 3.5e-34, (32.7% identity in 468 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. AMI2_MYCTU|AMIB2|Q11056|Rv1263|MT1301|MTCY50.19c|cy50.19c AMIDASE (462 aa), FASTA scores: opt: 1141, E(): 2.9e-60,(45.4% identity in 454 aa overlap); etc. Contains PS00571 Amidases signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE AMIDASE FAMILY. X2BK85,P63491 No NC_002945.3 Mycobrowser_v2 CDS 2618017 2618319 . - 0 Mb2390c HYPOTHETICAL PROTEIN Mb2390c, -, len: 100 aa. Equivalent to Rv2369c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Hypothetical unknown protein. Q7TYR3 No conserved hypotheticals Rv2369c NC_002945.3 Mycobrowser_v2 CDS 2614818 2615159 . - 0 Mb2386c CONSERVED HYPOTHETICAL PROTEIN Mb2386c, -, len: 113 aa. Equivalent to Rv2365c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Conserved hypothetical protein, highly similar to Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein from Mycobacterium leprae (108 aa), FASTA scores: opt: 426, E(): 1.4e-18, (67.9% identity in 106 aa overlap). Also highly similar to Q9RDF3|SCC77.05 from Streptomyces coelicolor (132 aa), FASTA scores: opt: 254, E(): 1.9e-18,(53.1% identity in 96 aa overlap). Equivalent to AAK46728 from Mycobacterium tuberculosis strain CDC1551 (93 aa) but longer 20 aa. Q7TYR4 No conserved hypotheticals Rv2365c NC_002945.3 Mycobrowser_v2 CDS 2615131 2616438 . - 0 Mb2387c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2387c, -, len: 435 aa. Equivalent to Rv2366c,len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 435 aa overlap). Probable conserved transmembrane protein, highly similar to Q9L2L3|SCC117.07 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (358 aa), FASTA scores: opt: 1159, E(): 5.5e-64, (53.0% identity in 353 aa overlap); ans similar to hypothetical proteins and hemolysin-related proteins e.g. Q9HN02|HLP|VNG2308G HEMOLYSIN PROTEIN from Halobacterium sp. strain NRC-1 (457 aa), FASTA scores: opt: 623, E(): 6.2e-31, (28.4% identity in 433 aa overlap); etc. Potential transmembrane protein with 2 CBS domains. BELONGS TO THE UPF0053 FAMILY. X2BKF9,P67131 No cell wall and cell processes Rv2366c NC_002945.3 Mycobrowser_v2 CDS 2616435 2616983 . - 0 Mb2388c conserved hypothetical protein Mb2388c, -, len: 182 aa. Equivalent to Rv2367c,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Conserved hypothetical protein, equivalent to Q49752|YN67_MYCLE|ML0628|B1937_F1_21 HYPOTHETICAL 19.8 KDA PROTEIN from Mycobacterium leprae (178 aa), FASTA scores: opt: 1051, E(): 2e-59, (89.1% identity in 175 aa overlap). Also highly similar to others e.g. Q9L2L4|SCC117.06 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (165 aa), FASTA scores: opt: 599, E(): 6e-31,(56.5% identity in 154 aa overlap); Q9KD56|BH1363 HYPOTHETICAL PROTEIN from Bacillus halodurans (159 aa),FASTA scores: opt: 311, E(): 8.3e-13, (45.05% identity in 111 aa overlap); etc. X2BKV6,P67135 No conserved hypotheticals Rv2367c NC_002945.3 Mycobrowser_v2 CDS 2630138 2635186 . - 0 Mb2401c mbtE PEPTIDE SYNTHETASE MBTE (PEPTIDE SYNTHASE) Mb2401c, mbtE, len: 1682 aa. Equivalent to Rv2380c,len: 1682 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1682 aa overlap). mbtE, peptide synthetase (see citations below), similar in part to several synthases e.g. O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 2635, E(): 1.9e-146, (36.8% identity in 1657 aa overlap); O05647|SNBDE VIRGINIAMYCIN S SYNTHETASE (FRAGMENT) from Streptomyces virginiae (1997 aa) FASTA scores: opt: 2580, E(): 1.6e-143, (40.65% identity in 1163 aa overlap); Q9R9I2|DHBF PROTEIN INVOLVED IN SIDEROPHORE PRODUCTION from Bacillus subtilis (2378 aa), FASTA scores: opt: 2388, E(): 3.6e-132, (33.9% identity in 1579 aa overlap); O68487|ACMB ACTINOMYCIN SYNTHETASE II from Streptomyces chrysomallus (2611 aa),FASTA scores: opt: 2165, E(): 4.9e-119, (35.0% identity in 1634 aa overlap); etc. Equivalent to AAK46743 from Mycobacterium tuberculosis strain CDC1551 (1787 aa) but shorter 105 aa. Contains PS00455 putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7TYQ7 No NC_002945.3 Mycobrowser_v2 CDS 2616987 2618045 . - 0 Mb2389c phoH1 PROBABLE PHOH-LIKE PROTEIN PHOH1 (PHOSPHATE STARVATION-INDUCIBLE PROTEIN PSIH) Mb2389c, phoH1, len: 352 aa. Equivalent to Rv2368c,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Probable phoH1,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein, equivalent to Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-LIKE PROTEIN from Mycobacterium leprae (349 aa), FASTA scores: opt: 1952, E(): 4.7e-107, (88.9% identity in 352 aa overlap). Also highly similar to Q9L2L5|SCC117.05 PHOH-LIKE PROTEIN from Streptomyces coelicolor (359 aa), FASTA scores: opt: 1407, E(): 3.6e-75, (63.6% identity in 349 aa overlap); Q9RSY1|DR1988 PHOH-RELATED PROTEIN from Deinococcus radiodurans (380 aa), FASTA scores: opt: 1053, E(): 1.9e-54, (53.3% identity in 349 aa overlap); Q9KD58|PHOH|BH1361 PHOSPHATE STARVATION-INDUCED PROTEIN from Bacillus halodurans (320 aa), FASTA scores: opt: 1019, E(): 1.6e-52, (54.35% identity in 300 aa overlap); P46343|PHOL_BACSU PHOH-LIKE PROTEIN from Bacillus subtilis (319 aa), FASTA scores: opt: 1014, E(): 3.2e-52, (50.8% identity in 303 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOH FAMILY. Note that previously known as phoH. X2BK92,P0A5S1 No NC_002945.3 Mycobrowser_v2 CDS 2618316 2619629 . - 0 Mb2391c CONSERVED HYPOTHETICAL PROTEIN Mb2391c, -, len: 437 aa. Equivalent to Rv2370c,len: 437 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 437 aa overlap). Conserved hypothetical protein, member of family proteins from Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1943, E(): 9.4e-115, (69.9% identity in 409 aa overlap); Rv1194c|MTCI364.06c; etc. Also similar to AAK45764|MT1500 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (432 aa), FASTA scores: opt: 1934, E(): 9.4e-115, (69.9% identity in 409 aa overlap). Q7TYR2 No conserved hypotheticals Rv2370c NC_002945.3 Mycobrowser_v2 CDS 2619824 2620009 . + 0 Mb2392 PE_PGRS40 pe-pgrs family protein pe_pgrs40 Mb2392, PE_PGRS40, len: 61 aa. Equivalent to Rv2371, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 61 aa overlap). Short protein,member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to N-terminal part of others e.g. AAK44356|MT0132 PE_PGRS FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (561 aa), FASTA scores: opt: 217, E( ): 4.9e-08,(69.65% identity in 56 aa overlap); etc. Q7TYR1 No PE/PPE Rv2371 NC_002945.3 Mycobrowser_v2 CDS 2620108 2620896 . - 0 Mb2393c CONSERVED HYPOTHETICAL PROTEIN Mb2393c, -, len: 262 aa. Equivalent to Rv2372c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Conserved hypothetical protein, equivalent to Q9CCN1|ML0626 HYPOTHETICAL PROTEIN from Mycobacterium leprae (257 aa),FASTA scores: opt: 1277, E(): 3e-71, (77.25% identity in 255 aa overlap). Also highly similar to others e.g. Q9RDD9|SDRD HYPOTHETICAL 26.1 KDA PROTEIN from Streptomyces coelicolor (249 aa), FASTA scores: opt: 624,E(): 3.2e-31, (45.05% identity in 253 aa overlap); P54461|YQEU_BACSU hypothetical 28.8 kd protein from Bacillus subtilis (256 aa), FASTA scores: opt: 375, E(): 6e-16, (32.5% identity in 234 aa overlap); etc. C-terminal half highly similar to Q49763|B1937_F2_57 from Mycobacterium leprae (128 aa), FASTA scores: opt: 577,E(): 1.4e-28, (75.8% identity in 124 aa overlap). BELONGS TO THE UPF0088 FAMILY. X2BKW0,P67203 No conserved hypotheticals Rv2372c NC_002945.3 Mycobrowser_v2 CDS 2620910 2622058 . - 0 Mb2394c dnaJ2 PROBABLE CHAPERONE PROTEIN DNAJ2 Mb2394c, dnaJ2, len: 382 aa. Equivalent to Rv2373c,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 382 aa overlap). Probable dnaJ2,chaperone protein, equivalent to Q49762|DNJ2_MYCLE|ML0625|B1937_F2_56 CHAPERONE PROTEIN from Mycobacterium leprae (378 aa), FASTA scores: opt: 2301, E(): 1.7e-120, (87.5% identity in 382 aa overlap). Also highly similar to OTHER CHAPERONE PROTEINS DNAJ/DNAJ2 e.g. Q9RDD7|DNJ2_STRCO|SCC77.21c from Streptomyces coelicolor (378 aa), FASTA scores: opt: 1456, E(): 1.2e-73, (54.8% identity in 385 aa overlap); O52164|DNJ2_STRAL from Streptomyces albus (379 aa) FASTA scores: opt: 1378, E(): 2.6e-69, (52.2% identity in 385 aa overlap); Q9S5A3|DNAJ_LISMO from Listeria monocytogenes (377 aa), FASTA scores: opt: 1013, E(): 4.6e-49, (41.3% identity in 385 aa overlap); etc. Also similar to Rv0352|MTCY13E10.12 from Mycobacterium tuberculosis. Contains 1 J domain and 1 CR domain. BELONGS TO THE DNAJ FAMILY. X2BKA0,P63967 No NC_002945.3 Mycobrowser_v2 CDS 2845283 2845993 . + 0 Mb2588 conserved protein Mb2588, -, len: 236 aa. Equivalent to Rv2558, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Conserved hypothetical protein, highly similar only to downstream ORF Q50741|MTCY9C4.11c|Rv2557|MT2645 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (224 aa), FASTA scores: opt: 1007, E(): 4.7e-59, (69.2% identity in 224 aa overlap). X2BKT8 No conserved hypotheticals Rv2558 NC_002945.3 Mycobrowser_v2 CDS 2775107 2775532 . + 0 Mb2522 vapc38 possible toxin vapc38. contains pin domain. Mb2522, -, len: 141 aa. Equivalent to Rv2494, len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P95023|EMBL:Z83863|MTCY159.26|Rv2530c (139 aa) FASTA scores: opt: 380 E(): 6.6e-19, (48.0% identity in 125 aa overlap); O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: 287, E(): 1.3e-12, (41.6% identity in 125 aa overlap); AAK46915|MT2605 (strain CDC1551) (139 aa) FASTA scores: opt: 380, E(): 6.6e-19 (48.0% identity in 125 aa overlap); etc. Q7TYG3 No virulence, detoxification, adaptation Rv2494 NC_002945.3 Mycobrowser_v2 CDS 2622133 2623164 . - 0 Mb2395c hrcA probable heat shock protein transcriptional repressor hrca Mb2395c, hrcA, len: 343 aa. Equivalent to Rv2374c,len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 343 aa overlap). Probable hrcA,heat-inducible transcriptional repressor, equivalent to Q9CCN2|HRCA|ML0624 PUTATIVE HEAT-INDUCIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (343 aa), FASTA scores: opt: 1926, E(): 3.9e-107, (89.8% identity in 343 aa overlap). Also highly similar to other heat-inducible transcription repressor proteins e.g. Q9RDD6|HRCA|SCC77.22c from Streptomyces coelicolor (338 aa), FASTA scores: opt: 1227, E(): 1.1e-65, (58.8% identity in 335 aa overlap); O52163|HRCA_STRAL from Streptomyces albus (338 aa), FASTA scores: opt: 1196, E(): 7.7e-64, (56.1% identity in 335 aa overlap); P25499|HRCA_BACSU HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR from Bacillus subtilis (343 aa), FASTA scores: opt: 538,E(): 8.4e-25, (28.9% identity in 325 aa overlap); etc. Almost identical, but conflict at C-terminus, to Q49749|YGRP|B1937_F1_18 PUTATIVE HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR from Mycobacterium leprae (197 aa) FASTA scores: opt: 1126, E(): 6.9e-60, (91.8% identity in 195 aa overlap). BELONGS TO THE HRCA FAMILY. X2BKW5,P64399 No NC_002945.3 Mycobrowser_v2 CDS 2623680 2624186 . - 0 Mb2397c cfp2 LOW MOLECULAR WEIGHT ANTIGEN CFP2 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 2) (CFP-2) Mb2397c, cfp2, len: 168 aa. Equivalent to Rv2376c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). cfp2 (alternate gene name: mtb12), low molecular weight antigen, secreted protein similar to Q49771|MB12_MYCLE|ML0620|B1937_F3_91 LOW MOLECULAR WEIGHT ANTIGEN MTB12 HOMOLOG PRECURSOR from Mycobacterium leprae (167 aa), FASTA scores: opt: 682,E(): 1.7e-32, (65.5% identity in 165 aa overlap). BELONGS TO THE MTB12 FAMILY. X2BKH3,P0A5P9 No NC_002945.3 Mycobrowser_v2 CDS 2624286 2624501 . - 0 Mb2398c mbtH PUTATIVE CONSERVED PROTEIN MBTH Mb2398c, mbtH, len: 71 aa. Equivalent to Rv2377c,len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 71 aa overlap). Putative mbtH,conserved protein with no function assigned (see first and second citation), similar to hypothetical proteins or proteins found in several gene clusters for biosynthesis or transport of siderophores and other nonribosomally synthesized peptides e.g. Q9Z388|SCE8.11c PUTATIVE SMALL CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (71 aa), FASTA scores: opt: 345, E(): 1.4e-19,(68.2% identity in 66 aa overlap); Q9F8V3|CUMB COUY PROTEIN (probably involved in the biosynthesis of aminocoumarin antibiotic coumermycin A(1)) (see third citation below) from Streptomyces rishiriensis (71 aa),FASTA scores: opt: 329, E(): 2.2e-18, (63.2% identity in 68 aa overlap); Q9F5J2|SIM-CB MBTH-LIKE PROTEIN (probably protein involved in the biosynthesis of aminocoumarin antibiotic coumermycin A(1)) from Streptomyces antibioticus (70 aa), FASTA scores: opt: 308, E(): 8.4e-17, (65.6% identity in 64 aa overlap); Q9FB14 MBTH-LIKE PROTEIN (involved in the biosynthesis of the antitumor drug bleomycin) (see fourth citation below) from Streptomyces verticillus FASTA scores: opt: 220, E(): 8.8e-10, (41.2% identity in 68 aa overlap); etc. X2BKW6 No NC_002945.3 Mycobrowser_v2 CDS 2624479 2625774 . - 0 Mb2399c mbtG LYSINE-N-OXYGENASE MBTG (L-LYSINE 6-MONOOXYGENASE) (LYSINE N6-HYDROXYLASE) Mb2399c, mbtG, len: 431 aa. Equivalent to Rv2378c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). mbtG, lysine-N -oxygenase (hydroxylase) (EC 1.14.13.59) showing some similarity with various proteins including ornithine and lysine-N-oxygenases, e.g. Q9K6Q1|TRKA|BH3677 POTASSIUM UPTAKE PROTEIN from Bacillus halodurans (350 aa), FASTA scores: opt: 153, E(): 0.016, (25.2% identity in 246 aa overlap); P56584|SID1_USTMA L-ORNITHINE 5-MONOOXYGENASE (EC 1.13.12.-) from Ustilago maydis (Smut fungus) (570 aa), FASTA scores: opt: 136, E(): 0.31, (22.85% identity in 127 aa overlap); Q9HHV0|HXYA|VNG6214G MONOOXYGENASE from Halobacterium sp. strain NRC-1 (477 aa), FASTA scores: opt: 119, E(): 3.4, (40.0% identity in 70 aa overlap); O69828|SC1A6.23 PUTATIVE LYSINE N-HYDROXLASE (FRAGMENT) from Streptomyces coelicolor (134 aa), BLAST score: 76 (similarity in part for this one); etc. COFACTORS: FAD (BY SIMILARITY). X2BKA8,Q7TYQ9 No NC_002945.3 Mycobrowser_v2 CDS 2625771 2630156 . - 0 Mb2400c mbtF PEPTIDE SYNTHETASE MBTF (PEPTIDE SYNTHASE) Mb2400c, mbtF, len: 1461 aa. Equivalent to Rv2379c,len: 1461 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1461 aa overlap). mbtF, peptide synthetase (see citations below), similar in part to several synthases e.g. O52820|PCZA363.4 PROTEIN from Amycolatopsis orientalis (4077 aa), FASTA scores: opt: 1873, E(): 1.1e-99, (35.55% identity in 1522 aa overlap); O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 1817, E(): 2.1e-96, (33.65% identity in 1463 aa overlap); O52821 PROTEIN SIMILAR TO PEPTIDE SYNTHETASE from Amycolatopsis orientalis (1860 aa) FASTA scores: opt: 1705, E(): 2.9e-90, (34.75% identity in 1344 aa overlap); Q9XCF2|PSTB PUTATIVE PEPTIDE SYNTHETASE (similar to Mycobacterium tuberculosis nrp protein) from Mycobacterium avium (2552 aa), FASTA scores: opt: 1687, E(): 4e-89,(35.45% identity in 1058 aa overlap); Q9ZET7 PEPTIDE SYNTHETASE (FRAGMENT) from Mycobacterium smegmatis (1438 aa), FASTA scores: opt: 1479, E(): 2.5e-77, (30.45% identity in 1507 aa overlap); etc. Contains PS00455 putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7TYQ8 No NC_002945.3 Mycobrowser_v2 CDS 2800307 2800558 . - 0 Mb2546c unknown protein Mb2546c, -, len: 83 aa. Equivalent to Rv2517c, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Hypothetical unknown protein. Equivalent to AAK46899 from Mycobacterium tuberculosis strain CDC1551 (97 aa) but shorter 14 aa. Q7TYE4 No conserved hypotheticals Rv2517c NC_002945.3 Mycobrowser_v2 CDS 2635326 2638340 . - 0 Mb2402c mbtD POLYKETIDE SYNTHETASE MBTD (POLYKETIDE SYNTHASE) Mb2402c, mbtD, len: 1004 aa. Equivalent to Rv2381c,len: 1004 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1004 aa overlap). mbtD,polyketide synthase (see citations below), similar in part to several synthases e.g. Q03132|ERY2_SACER|ERYA ERYTHRONOLIDE SYNTHASE, MODULES 3 AND 4 (EC 2.3.1.94) from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa), FASTA scores: opt: 971, E(): 1e-46, (29.35% identity in 1043 aa overlap); Q9F829|MEGAII MEGALOMICIN 6-DEOXYERYTHRONOLIDE B SYNTHASE 2 from Micromonospora megalomicea subsp. nigra (3562 aa), FASTA scores: opt: 787, E(): 2.4e-36, (29.35% identity in 1032 aa overlap); Q9L4W4|NYSB POLYKETIDE SYNTHASE from Streptomyces noursei (3192 aa), FASTA scores: opt: 761, E(): 6.6e-35, (29.55% identity in 1086 aa overlap); O30764|NIDA1 POLYKETIDE SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 aa), FASTA scores: opt: 726, E(): 7.8e-33, (27.3% identity in 1052 aa overlap); etc. Contains PS00012 Phosphopantetheine attachment site. Q7TYQ6 No NC_002945.3 Mycobrowser_v2 CDS 2638340 2639674 . - 0 Mb2403c mbtC POLYKETIDE SYNTHETASE MBTC (POLYKETIDE SYNTHASE) Mb2403c, mbtC, len: 444 aa. Equivalent to Rv2382c,len: 444 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 444 aa overlap). mbtC, polyketide synthase (see citations below), similar in part to several synthases e.g. Q9F7T9 AVERMECTIN POLYKETIDE SYNTHASE (FRAGMENT) from Streptomyces avermitilis (3626 aa), FASTA scores: opt: 1458, E(): 7e-82, (50.65% identity in 446 aa overlap); AAG23264|SPNA POLYKETIDE SYNTHASE LOADING AND EXTENDER MODULE 1 from Saccharopolyspora spinosa (2595 aa) FASTA scores: opt: 1441, E(): 6e-81, (49.1% identity in 446 aa overlap); O33954|TYLG TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 from Streptomyces fradiae (4472 aa) FASTA scores: opt: 1439, E(): 1.2e-80, (51.0% identity in 447 aa overlap); O30764|NIDA1 POLYKETIDE SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 aa) FASTA scores: opt: 1432, E(): 3.3e-80, (50.9% identity in 442 aa overlap); etc. Q7TYQ5 No NC_002945.3 Mycobrowser_v2 CDS 2639664 2643908 . - 0 Mb2404c mbtB PHENYLOXAZOLINE SYNTHASE MBTB (PHENYLOXAZOLINE SYNTHETASE) Mb2404c, mbtB, len: 1414 aa. Equivalent to Rv2383c,len: 1414 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1414 aa overlap). mbtB,phenyloxazoline synthase (see citations below), similar to the N-terminal region of several synthetases e.g. Q9EWP5|SC4C2.17 PUTATIVE NON-RIBOSOMAL PEPTIDE SYNTHASE from Streptomyces coelicolor (2229 aa), FASTA scores: opt: 2878, E(): 4.1e-156, (46.85% identity in 1138 aa overlap); Q9Z399|IRP2 YERSINIABACTIN BIOSYNTHETIC from Yersinia pestis (2041 aa), FASTA scores: opt: 2297, E(): 5.3e-123,(38.55% identity in 1069 aa overlap); P48633|HMP2_YEREN|IRP2 HIGH-MOLECULAR-WEIGHT PROTEIN 2 (MAY BE INVOLVED IN THE NONRIBOSOMAL SYNTHESIS OF SMALL PEPTIDES) from Yersinia enterocolitica (2035 aa), FASTA scores: opt: 2275, E(): 9.4e-122, (38.45% identity in 1069 aa overlap); O85739|PCHE|PA4226 DIHYDROAERUGINOIC ACID SYNTHETASE from Pseudomonas aeruginosa (1438 aa) FASTA scores: opt: 2236, E(): 1.2e-119, (38.2% identity in 1330 aa overlap); Q9RFM8|PCHE PYOCHELIN SYNTHETASE from Pseudomonas aeruginosa (1438 aa), FASTA scores: opt: 2229,E(): 3e-119, (38.0% identity in 1329 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature,and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. X2BKB5,Q7TYQ4 No NC_002945.3 Mycobrowser_v2 CDS 2644007 2645704 . + 0 Mb2405 mbtA BIFUNCTIONAL ENZYME MBTA: SALICYL-AMP LIGASE (SAL-AMP LIGASE) + SALICYL-S-ArCP SYNTHETASE Mb2405, mbtA, len: 565 aa. Equivalent to Rv2384,len: 565 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 565 aa overlap). mbtA, bifunctional enzyme, including salicyl-AMP ligase (Sal-AMP ligase) (EC 6.-.-.-) and salicyl-S-ArCP synthetase (see first and second citations below), highly similar to other ligases e.g. Q9F638|MXCE from Stigmatella aurantiaca 2,3-DHBA-AMP ligase (protein involved in the biosynthesis of 2,3-dihydroxybenzoic acid, contains the AMP binding signature) (543 aa), FASTA scores: opt: 1683, E(): 2.8e-90, (48.25% identity in 545 aa overlap) (see third citation below); P40871|DHBE_BACSU|ENTE 2,3-DIHYDROXYBENZOATE-AMP LIGASE (EC 6.3.2.-) from Bacillus subtilis (539 aa), FASTA scores: opt: 1569, E(): 1.2e-83, (44.9% identity in 532 aa overlap); O07899|VIBE_VIBCHVC0772 VIBRIOBACTIN-SPECIFIC 2,3-DIHYDROXYBENZOATE-AMP LIGASE from Vibrio cholerae (543 aa), FASTA scores: opt: 1457, E(): 3.7e-77, (44.6% identity in 545 aa overlap); etc. Also similar to P95819|SNBA PRISTINAMYCIN I SYNTHETASE I from Streptomyces pristinaespiralis (582 aa), FASTA scores: opt: 1532, E(): 1.7e-81, (46.35% identity in 548 aa overlap); and Q9RFM9|PCHD SALICYL-AMP LIGASE from Pseudomonas aeruginosa (547 aa), FASTA scores: opt: 1415, E(): 1e-74, (45.95% identity in 533 aa overlap). Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7TYQ3 No lipid metabolism Rv2384 NC_002945.3 Mycobrowser_v2 CDS 2938333 2938566 . + 0 Mb2681 HYPOTHETICAL PROTEIN Mb2681, -, len: 77 aa. Equivalent to Rv2663, len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Hypothetical unknown protein. Q7TY60 No conserved hypotheticals Rv2663 NC_002945.3 Mycobrowser_v2 CDS 2835607 2836020 . + 0 Mb2576 vapc18 possible toxin vapc18 Mb2576, -, len: 137 aa. Equivalent to Rv2546, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein. Some similarity to several HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. P96411|Rv0229c|MTCY08D5.24c (226 aa), FASTA scores: opt: 272, E(): 1.3e-11, (39.7% identity in 136 aa overlap); O33299|Rv2757c|MTV002.22c (138 aa), FASTA scores: opt: 265, E(): 2.5e-11, (38.5% identity in 135 aa overlap); P95026|Rv2527|MTCY159.29c (133 aa), FASTA scores: opt: 206, E(): 2.6e-07, (38.0% identity in 100 aa overlap); etc. Q7TYB9 No virulence, detoxification, adaptation Rv2546 NC_002945.3 Mycobrowser_v2 CDS 2645800 2646720 . + 0 Mb2406 mbtJ PUTATIVE ACETYL HYDROLASE MBTJ Mb2406, mbtJ, len: 306 aa. Equivalent to Rv2385,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 306 aa overlap). Putative mbtJ, acetyl hydrolase (EC 3.1.1.-) (see citations below), showing some similarity with various hydrolases including acetyl hydrolases e.g. Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE/ESTERASE from Mycobacterium leprae (335 aa),FASTA scores: opt: 449, E(): 6.7e-21, (33.85% identity in 313 aa overlap); AAK47950|MT3591 Esterase from M. tuberculosis strain CDC1551 (327 aa), FASTA scores: opt: 469, E(): 3.6e-22, (35% identity in 283 aa overlap); Q9X8J4|SCE9.22 PUTATIVE ESTERASE from Streptomyces coelicolor (266 aa), FASTA scores: opt: 430,E(): 8.5e-20,(38% identity in 245 aa overlap); Q01109|BAH_STRHY ACETYL-HYDROLASE (EC 3.1.1.-) from Streptomyces hygroscopicus (299 aa), FASTA scores: opt: 420, E(): 4e-19, (35.1% identity in 265 aa overlap). Equivalent to AAK46748 from Mycobacterium tuberculosis strain CDC1551 (327 aa) but shorter 21 aa. Note that previously known as lipK. Q7TYQ2 No lipid metabolism Rv2385 NC_002945.3 Mycobrowser_v2 CDS 4086939 4087259 . - 0 Mb3733c CONSERVED HYPOTHETICAL PROLINE RICH PROTEIN Mb3733c, -, len: 106 aa. Equivalent to Rv3706c,len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 106 aa overlap). Conserved ypothetical pro-rich protein, only similar to upstream ORF Rv3705A (129 aa), and AAK48176|MT3808.1 HYPOTHETICAL 13.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (129 aa), FASTA scores: opt: 245, E(): 4.4e-06, (40.7% identity in 113 aa overlap). Q7TVV8 No conserved hypotheticals Rv3706c NC_002945.3 Mycobrowser_v2 CDS 2646724 2648076 . - 0 Mb2407c mbtI isochorismate synthase mbti Mb2407c, mbtI, len: 450 aa. Equivalent to Rv2386c,len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 450 aa overlap). Putative mbtI,isochorismate synthase (see citations below), similar to Q9X9I8|IRP9 SALICYLATE SYNTHETASE from Yersinia enterocolitica (434 aa), FASTA scores: opt: 887, E(): 7.5e-48, (37.45% identity in 422 aa overlap); and similar in C-terminal region to many anthranilate synthases component I (EC 4.1.3.27) e.g. Q9Z4W7|TRPE_STRCO|SCE8.07c from Streptomyces coelicolor (511 aa), FASTA scores: opt: 509, E(): 3e-24, (40.4% identity in 255 aa overlap); P33975|TRPE_HALVO from Halobacterium volcanii (Haloferax volcanii) (523 aa) FASTA scores: opt: 488, E(): 6.2e-23,(34.2% identity in 298 aa overlap); and similar to Q08653|TRPE_THEMA|TM0142 ANTHRANILATE SYNTHASE COMPONENT I from Thermotoga maritima (461 aa), FASTA scores: opt: 478,E(): 2.3e-22, (28.4% identity in 440 aa overlap); etc. COULD BE BELONG TO THE ANTHRANILATE SYNTHASE COMPONENT I FAMILY. Note that previously known as trpE2, an anthranilate synthase component I (EC 4.1.3.27). X2BKI5,Q7TYQ1 No NC_002945.3 Mycobrowser_v2 CDS 2648529 2648738 . + 0 Mb2407A HYPOTHETICAL PROTEIN Mb2407A, -, len: 69 aa. Equivalent to MT2455 from Mycobacterium tuberculosis strain CDC1551, (100% identity in 69 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb2407A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BKY3 No NC_002945.3 Mycobrowser_v2 CDS 2648836 2650089 . + 0 Mb2408 conserved protein Mb2408, -, len: 417 aa. Equivalent to Rv2387, len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 417 aa overlap). Conserved hypothetical protein, showing some similarities with others e.g. Q9K663|BH3869 HYPOTHETICAL PROTEIN from Bacillus halodurans (337 aa), FASTA scores: opt: 343, E(): 4.8e-14, (29.0% identity in 400 aa overlap); AAK25471|CC3509 HYPOTHETICAL PROTEIN from Caulobacter crescentus (365 aa), FASTA scores: opt: 282, E(): 3.2e-10,(32.6% identity in 399 aa overlap); P73953|SLR1512 [D90911_21] CONSERVED HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC6803 (374 aa), FASTA scores: opt: 230, E(): 5.5e-07; (24.75% identity in 408 aa overlap); etc. Contains PS00213 Lipocalin signature. Q7TYQ0 No conserved hypotheticals Rv2387 NC_002945.3 Mycobrowser_v2 CDS 2650086 2651213 . - 0 Mb2409c hemN PROBABLE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE HEMN (COPROPORPHYRINOGENASE) (COPROGEN OXIDASE) Mb2409c, hemN, len: 375 aa. Equivalent to Rv2388c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 375 aa overlap). Probable hemN,oxygen-independent coproporphyrinogen III oxidases (EC 1.3.3.-), highly similar to many PUTATIVE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASES e.g. Q9RDD2|SCC77.26 from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1358, E(): 1.5e-76, (56.55% identity in 382 aa overlap); BAB51237|MLR4627 from Rhizobium loti (Mesorhizobium loti) (392 aa), FASTA scores: opt: 696,E(): 1.1e-35, (36.8% identity in 383 aa overlap); Q9KUR0|VC0455 from Vibrio cholerae (391 aa), FASTA scores: opt: 691, 2.2e-35, (32.65% identity in 386 aa overlap); P54304|HEMN_BACSU from Bacillus subtilis (366 aa), FASTA scores: opt: 668 , E(): 5.6e-34; (34.9% identity in 327 aa overlap); etc. Equivalent to AAK46752 from Mycobacterium tuberculosis strain CDC1551 (390 aa) but shorter 375 aa. BELONGS TO THE ANAEROBIC COPROPORPHYRINOGEN III OXIDASE FAMILY. Q7TYP9 No NC_002945.3 Mycobrowser_v2 CDS 2718476 2719735 . - 0 Mb2476c conserved protein Mb2476c, -, len: 419 aa. Equivalent to Rv2449c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 419 aa overlap). Conserved hypothetical protein, highly similar to hypothetical proteins e.g. P95139|Rv2953|MTCY349.37c from M. tuberculosis (418 aa), FASTA scores: opt: 1829, E(): 4.7e-103, (67.3% identity in 419 aa overlap); AAK47353|MT3027 from Mycobacterium tuberculosis strain CDC1551 (418 aa), FASTA score: opt: 1829, E(): 4.7e-103,(67.3 identity in 419 aa overlap); Q9CD87|ML0129 from Mycobacterium leprae (418 aa), FASTA scores: opt: 1727,E(): 6.8e-97, (65.45% identity in 414 aa overlap); etc. Q7TYK0 No conserved hypotheticals Rv2449c NC_002945.3 Mycobrowser_v2 CDS 2651319 2651783 . - 0 Mb2410c rpfD PROBABLE RESUSCITATION-PROMOTING FACTOR RPFD Mb2410c, rpfD, len: 154 aa. Equivalent to Rv2389c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Probable rpfD,resuscitation-promoting factor. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citation below). Similar to others from Mycobacterium tuberculosis e.g. O07747|Rv1884c|MTCY180.34|RPFC PROBABLE RESUSCITATION-PROMOTING FACTOR from Mycobacterium tuberculosis (176 aa), FASTA scores: opt: 382, E(): 2.3e-17, (55.45% identity in 101 aa overlap); etc. Also similarity with Q9CBF8|ML2030 HYPOTHETICAL PROTEIN from Mycobacterium leprae (157 aa), FASTA scores: opt: 397,E(): 2.4e-18, (47.95% identity in 121 aa overlap); Q9F2Q2|SCE41.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 341,E(): 1.1e-14, (40.45% identity in 131 aa overlap); and O86308|Z96935|MLRPF_1 RPF PROTEIN PRECURSOR from Micrococcus luteus (220 aa), FASTA scores: opt: 301, E(): 3.6e-12, (39.4% identity in 132 aa overlap). Contains a secretory signal sequence in N-terminus. Supposed acts at very low concentration. Q7TYP8 No NC_002945.3 Mycobrowser_v2 CDS 2651780 2652337 . - 0 Mb2411c CONSERVED HYPOTHETICAL PROTEIN Mb2411c, -, len: 185 aa. Equivalent to Rv2390c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 185 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis proteins Q11032|YD62_MYCTU|MTCY02B10.26c|Rv1362c hypothetical 23.5 kd protein (220 aa), FASTA scores: opt: 223, E(): 2.1e-07, (27.4% identity in 190 aa overlap); and Q11033|YD63_MYCTU|MTCY02B10.27c|Rv1363c hypothetical 28.3 kd protein (261 aa), FASTA scores: opt: 238, E(): 2.7e-08,(27.6% identity in 163 aa overlap). Q7TYP7 No conserved hypotheticals Rv2390c NC_002945.3 Mycobrowser_v2 CDS 2652750 2654441 . + 0 Mb2412 sira ferredoxin-dependent sulfite reductase sira Mb2412, nirA, len: 563 aa. Equivalent to Rv2391,len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 563 aa overlap). Probable nirA,ferredoxin-dependant nitrite reductase (EC 1.7.7.1),similar to many nitrate reductases e.g. CAC33947|SCBAC1A6.26c Putative nitrite/sulphite reductase from Streptomyces coelicolor (565 aa), FASTA scores: opt: 2335, E(): 1.2e-137, (60.1% identity in 567 aa overlap); Q9RZD6|DRA0013 FERREDOXIN-NITRITE REDUCTASE from Deinococcus radiodurans (563 aa), FASTA scores: opt: 1141,E(): 2.2e-63, (39.6% identity in 533 aa overlap); Q59656|NIRA (D31732|PEENIRNRT_1) ferredoxin-dependant* NITRITE REDUCTASE (*: see citation below) from Plectonema boryanum (654 aa), FASTA scores: opt: 805, E(): 1.9e-42,(31.7% identity in 517 aa overlap); Q55366|NIRA|SLR0898 FERREDOXIN-NITRITE REDUCTASE from Synechocystis sp. strain PCC 6803 (502 aa), FASTA scores: opt: 799, E(): 3.7e-42,(32.3% identity in 517 aa overlap). Highly similar (only in N-terminal part because shortened protein (fragment) owing to an IS900 insertion) to Q9K541|NIRA NITRATE REDUCTASE (FRAGMENT) from Mycobacterium paratuberculosis (198 aa), FASTA scores: opt: 798, E(): 2.1e-42, (65.4% identity in 182 aa overlap). X2BKZ0,Q7TYP6 No intermediary metabolism and respiration Rv2391 NC_002945.3 Mycobrowser_v2 CDS 2654438 2655202 . + 0 Mb2413 cysH probable 3'-phosphoadenosine 5'-phosphosulfate reductase cysh (paps reductase, thioredoxin dep.) (padops reductase) (3'-phosphoadenylylsulfate reductase) (paps sulfotransferase) Mb2413, cysH, len: 254 aa. Equivalent to Rv2392,len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Probable cysH,3'-phosphoadenosine 5'-phosphosulfate reductase (EC 1.8.4.8), similar to many e.g. P94498|O34620|CYH1_BACSU|CYSH from Bacillus subtilis (233 aa), FASTA scores: opt: 618, E(): 8.1e-32, (46.5% identity in 202 aa overlap); Q9KCT3|CYSH|BH1486 from Bacillus halodurans (231 aa), FASTA scores: opt: 560, E(): 3.6e-28,(41.3% identity in 230 aa overlap); P56860|CYSH_DEIRA from Deinococcus radiodurans (255 aa), FASTA scores: opt: 489,E(): 1.1e-23, (44.7% identity in 190 aa overlap); etc. BELONGS TO THE PAPS REDUCTASE FAMILY and CYSH SUBFAMILY. Note that operon cysA-cysW-cysT-subI, probably involved in sulfate transport, is near this putative ORF. X2BKC9,P65669 No intermediary metabolism and respiration Rv2392 NC_002945.3 Mycobrowser_v2 CDS 2655199 2656044 . + 0 Mb2414 che1 ferrochelatase che1 Mb2414, -, len: 281 aa. Equivalent to Rv2393, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Conserved hypothetical protein, with some similarity to Q9L2E8|SC7A8.10c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (274 aa), FASTA scores: opt: 407,E(): 2.8e-18, (37% identity in 246 aa overlap); CAC38793|SCI39.05 Conserved hypothetical protein from Streptomyces coelicolor (305 aa), FASTA scores: opt: 394,E(): 2e-17, (35.0% identity in 251 aa overlap); AAK44492|MT0272 Chalcone/stilbene synthase family protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 350, E(): 9.2e-15, (34.0% identity in 235 aa overlap); P95216|Rv0259c|MTCY06A4.03c|Z86089 hypothetical protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 345, E(): 1.9e-14,(33.6% identity in 235 aa overlap). Q7TYP5 No intermediary metabolism and respiration Rv2393 NC_002945.3 Mycobrowser_v2 CDS 2656081 2658012 . + 0 Mb2415 ggtB PROBABLE GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR GGTB (GAMMA-GLUTAMYLTRANSFERASE) (GLUTAMYL TRANSPEPTIDASE) Mb2415, ggtB, len: 643 aa. Equivalent to Rv2394,len: 643 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 643 aa overlap). Probable ggtB,gamma-glutamyltranspeptidase precursor (EC 2.3.2.2),similar to many e.g. Q9KVF2|VC0194 from Vibrio cholerae (588 aa), FASTA scores: opt: 943, E(): 7.5e-47, (40.0% identity in 597 aa overlap); O69935|SC3C8.26 from Streptomyces coelicolor (603 aa), FASTA scores: opt: 822,E(): 7.2e-40, (33.6% identity in 622 aa overlap); P54422|GGT_BACSU from Bacillus subtilis (587 aa) FASTA scores: opt: 491, E(): 8.2e-21, (33.4% identity in 574 aa overlap); etc. Has potential signal peptide and appropriately positioned prokaryotic lipoprotein attachment site (PS00013). Q7TYP4 No intermediary metabolism and respiration Rv2394 NC_002945.3 Mycobrowser_v2 CDS 2938577 2938831 . + 0 Mb2682 HYPOTHETICAL PROTEIN Mb2682, -, len: 84 aa. Equivalent to Rv2664, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Hypothetical protein. Some weak similarity to nearby P71964|Rv2667|clpX'|MT2741|MTCY441.36 POSSIBLE ATP-DEPENDENT PROTEASE ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (252 aa), FASTA scores: opt: 134, E(): 0.027, (31.15% identity in 77 aa overlap). Q7TY59 No conserved hypotheticals Rv2664 NC_002945.3 Mycobrowser_v2 CDS 2658143 2658583 . + 0 Mb2416 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [FIRST PART] Mb2416, -, len: 146 aa. Equivalent to 5' end of Rv2395, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 44 aa overlap). Probable conserved integral membrane protein, similar to AAK24613|CC2646 OLIGOPEPTIDE TRANSPORTER/OPT FAMILY PROTEIN from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts,Mb2416 and Mb2417. Q7TYP3 No NC_002945.3 Mycobrowser_v2 CDS 2658597 2660147 . + 0 Mb2417 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [SECOND PART] Mb2417, -, len: 516 aa. Equivalent to 3' end of Rv2395, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 516 aa overlap). Probable conserved integral membrane protein, similar to AAK24613|CC2646 OLIGOPEPTIDE TRANSPORTER/OPT FAMILY PROTEIN from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts,Mb2416 and Mb2417. Q7TYP2 No NC_002945.3 Mycobrowser_v2 CDS 2660296 2660511 . + 0 Mb2417A aprA Acid and phagosome regulated protein A AprA Mb2417A, len: 71 aa. Equivalent to Rv2395A len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). AprA, acid and phagosome regulated protein A, restricted to M. tuberculosis complex. Note completely overlapped by sRNA mcr7. X2BKD5 No conserved hypotheticals Rv2395A NC_002945.3 Mycobrowser_v2 CDS 2660623 2660787 . + 0 Mb2417B aprB Acid and phagosome regulated protein B AprB Mb2417B, len: 54 aa. Equivalent to Rv2395B len: 54 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 54 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). AprB, acid and phagosome regulated protein B, restricted to M. tuberculosis complex. X2BKY6 No conserved hypotheticals Rv2395B NC_002945.3 Mycobrowser_v2 CDS 2660871 2661953 . + 0 Mb2418 PE_PGRS41 pe-pgrs family protein pe_pgrs41 Mb2418, PE_PGRS41, len: 360 aa. Equivalent to Rv2396, len: 361 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 361 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. AAK47132|MT2812 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (454 aa), FASTA scores: opt: 1256, E(): 2.4e-44, (56.0% identity in 377 aa overlap); AAK46139|MT1866 PE_PGRS FAMILY PROTEIN from M. tuberculosis strain CDC1551 (491 aa), FASTA scores: opt: 1250, E(): 4.4e-44, (57.8% identity in 372 aa overlap); Y278_MYCTU|Rv0278C|MTV035.06c HYPOTHETICAL PE-PGRS FAMILY PROTEIN (957 aa), FASTA scores: opt: 1253, E(): 5.2e-44,(55.5% identity in 400 aa overlap); P71664|Rv1396c|MTCY21B4.13c HYPOTHETICAL GLYCINE-RICH 47.9 KDA PROTEIN (576 aa), FASTA scores: opt: 1236, E(): 1.8e-43, (55.55% identity in 402 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (gcc-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa). Q7TYP1 No NC_002945.3 Mycobrowser_v2 CDS 2661978 2663033 . - 0 Mb2419c cysA1 sulfate-transport atp-binding protein abc transporter cysa1 Mb2419c, cysA1, len: 351 aa. Equivalent to Rv2397c,len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 351 aa overlap). Probable cysA1,sulfate-transport ATP-binding protein ABC transporter (see citations below), similar to OTHER SULFATE ABC TRANSPORTER ATP-BINDING PROTEINS e.g. P14788|CYSA_SYNP7 from Synechococcus sp. (344 aa), FASTA scores: opt: 1112, E(): 2.6e-56, (54.6% identity in 328 aa overlap); P74548|CYSA_SYNY3 from Synechocystis sp. (355 aa), FASTA scores: opt: 1063, E(): 1.7e-53, (51.9% identity in 343 aa overlap); Q9I6L0|CYSA|PA0280 from Pseudomonas aeruginosa (329 aa), FASTA scores: opt: 987, E(): 3.3e-49, (49.2% identity in 339 aa overlap); etc. Also similar to many ATP-binding proteins from Mycobacterium tuberculosis e.g. Rv2038c, Rv1238, Rv2832c, etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that previously known as cysA. X2BKK1,P0A4W3 No NC_002945.3 Mycobrowser_v2 CDS 2663050 2663868 . - 0 Mb2420c cysW PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYSW Mb2420c, cysW, len: 272 aa. Equivalent to Rv2398c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 272 aa overlap). Probable cysW,sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. Q9K877|CYSW|BH3129 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (287 aa), FASTA scores: opt: 765, E(): 4.1e-40, (43.8% identity in 249 aa overlap); P27370|CYSW_SYNP7 sulfate transport system (permease) protein from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (286 aa), FASTA scores: opt: 757, E(): 1.3e-39, (44.3% identity in 264 aa overlap); Q9I6K9|CYSW|PA0281 SULFATE TRANSPORT PROTEIN from Pseudomonas aeruginosa (289 aa), FASTA scores: opt: 753,E(): 2.3e-39, (44.4% identity in 250 aa overlap); P16702|P76534|CYSW_ECOLI SULFATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (291 aa), FASTA scores: opt: 633,E(): 5.7e-32, (38.2% identity in 267 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature. SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS and BELONGS TO THE CYSTW SUBFAMILY. Q7TYP0 No NC_002945.3 Mycobrowser_v2 CDS 2663865 2664716 . - 0 Mb2421c cysT PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYST Mb2421c, cysT, len: 283 aa. Equivalent to Rv2399c,len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Probable cysT,sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. BAB48989|MLR1667 PERMEASE PROTEIN OF SULFATE ABC TRANSPORTER from Rhizobium loti (283 aa), FASTA scores: opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa overlap); Q9K878|CYST|BH3128 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (279 aa), FASTA scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa overlap); P16701|CYST_ECOLI|CYSU|CYST|B2424 from Escherichia coli (277 aa), FASTA scores: opt: 669, E(): 1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CYSTW SUBFAMILY. Q7TYN9 No NC_002945.3 Mycobrowser_v2 CDS 2664713 2665783 . - 0 Mb2422c subI PROBABLE SULFATE-BINDING LIPOPROTEIN SUBI Mb2422c, subI, len: 356 aa. Equivalent to Rv2400c,len: 356 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Probable subI,sulfate-binding lipoprotein component of sulfate transport system (see citations below), equivalent to Q9CCN3|SUBI|ML0615 (alias Q49748|B1937_F1_11, 358 aa) PUTATIVE SULPHATE-BINDING PROTEIN from Mycobacterium leprae (348 aa), FASTA scores: opt: 1775, E(): 2.3e-102,(76.45% identity in 340 aa overlap). Also similar to others and other substrate-binding proteins e.g. P27366|SUBI_SYNP7|SBPA SULFATE-BINDING PROTEIN PRECURSOR from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (350 aa), FASTA scores: opt: 703, E(): 4.6e-36, (35.6% identity in 351 aa overlap); Q9I6K7|SBP|PA0283 SULFATE-BINDING PROTEIN PRECURSOR from Pseudomonas aeruginosa (332 aa), FASTA scores: opt: 591, E(): 3.7e-29,(36.9% identity in 317 aa overlap); CAC49112|SMB21133 PUTATIVE SULFATE UPTAKE ABC TRANSPORTER PERIPLASMIC SOLUTE-BINDING PROTEIN PRECURSOR from Rhizobium meliloti (Sinorhizobium meliloti) (341 aa), FASTA scores: opt: 569,E(): 8.8e-28, (36.15% identity in 321 aa overlap); etc. BELONGS TO THE PROKARYOTIC SULFATE BINDING PROTEIN FAMILY. Q7TYN8 No NC_002945.3 Mycobrowser_v2 CDS 2665797 2666126 . + 0 Mb2423 HYPOTHETICAL PROTEIN Mb2423, -, len: 109 aa. Equivalent to Rv2401, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein. Equivalent to AAK46768 from Mycobacterium tuberculosis strain CDC1551 (134 aa) but shorter 25 aa. N-terminus extended since first submission (previously 72 aa). Q7TYN7 No conserved hypotheticals Rv2401 NC_002945.3 Mycobrowser_v2 CDS 2666111 2666314 . - 0 Mb2424c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb2424c, -, len: 67 aa. Equivalent to Rv2401A, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Possible conserved membrane protein, highly similar, but with 29 aa shorter,to ML0614|AL583919_34|Q49760 from Mycobacterium leprae (95 aa), FASTA scores: opt: 297, E(): 3.6e-15, (67.7% identity in 65 aa overlap). Has hydrophobic stretch. Q7TYN6 No cell wall and cell processes Rv2401A NC_002945.3 Mycobrowser_v2 CDS 4282801 4285044 . + 0 Mb3900 eccca1 esx conserved component eccca1. esx-1 type vii secretion system protein. possible transmembrane protein. Mb3900, -, len: 747 aa. Equivalent to Rv3870, len: 747 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 747 aa overlap). Possible conserved membrane protein, equivalent to O33087|ML0053|MLCB628.16c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (744 aa), FASTA scores: opt: 4333, E(): 0, (85.4% identity in 746 aa overlap); and similar to N-terminal end of others e.g. Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 1003, E(): 1e-52,(33.65% identity in 725 aa overlap); O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1078, E(): 3e-57, (35.4% identity in 774 aa overlap); P71068|YUKA YUKA PROTEIN from Bacillus subtilis (1207 aa) FASTA scores: opt: 529, E(): 4.3e-24,(26.1% identity in 636 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),FASTA scores: opt: 455, E(): 1.5e-19, (27.1% identity in 734 aa overlap); etc. Also similar to N-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 982,E(): 1.9e-51, (33.8% identity in 719 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 761, E(): 4.1e-38, (38.2% identity in 746 aa overlap); O53935|Rv1784|MTV049.06 (932 aa), FASTA scores: opt: 547,E(): 2.8e-25, (36.25% identity in 276 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in downstream ORF MTV027.06. Q7TVG6 No cell wall and cell processes Rv3870 NC_002945.3 Mycobrowser_v2 CDS 2666442 2668526 . + 0 Mb2425 conserved protein Mb2425, -, len: 694 aa. Equivalent to hypothetical protein from Mycobacterium tuberculosis strain Erdman ATCC 35801 (99% identity with 692 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Conserved hypothetical protein, highly similar to others e.g. 9X8C4|SCE36.11c CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) from Streptomyces coelicolor (612 aa). Contains Glycosyl hydrolases family 15 superfamily domain, a glucoamylase and related glycosyl hydrolases multi-domain and a oligosaccharide amylase multi-domain. Mb2425 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BL18 No NC_002945.3 Mycobrowser_v2 CDS 2668604 2669359 . - 0 Mb2426c lppR PROBABLE CONSERVED LIPOPROTEIN LPPR Mb2426c, lppR, len: 251 aa. Equivalent to Rv2403c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Probable lppR,conserved lipoprotein, with weak similarity with MYCOBACTERIAL SERINE/THREONINE PROTEIN KINASES (EC 2.7.1.-) e.g. AAK45563|MT1304 from Mycobacterium tuberculosis strain CDC1551 (626 aa), FASTA scores: opt: 186, E(): 0.00023, (24.4% identity in 238 aa overlap), and the C-terminal part of Q11053|Rv1266c|MTCY50.16|PKNH_MYCTU from Mycobacterium tuberculosis (626 aa), FASTA scores: opt: 185, E()= 0.00027, (24.35% identity in 238 aa overlap). Has signal peptide and appropriate positioned prokaryotic lipoprotein attachment site (PS00013). Could belong to the SER/THR FAMILY of protein kinases. Q7TYN4 No NC_002945.3 Mycobrowser_v2 CDS 2669356 2671317 . - 0 Mb2427c lepA PROBABLE GTP-BINDING PROTEIN LEPA (GTP-BINDING ELONGATION FACTOR) Mb2427c, lepA, len: 653 aa. Equivalent to Rv2404c,len: 653 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 653 aa overlap). Probable lepA,GTP-binding protein (a protein of unknown function, but apparently with membrane-related functions and very similar to protein synthesis elongation factors; see citations below). Equivalent to P53530|LEPA_MYCLE|ML0611|B1937_F3_81 GTP-BINDING PROTEIN from Mycobacterium leprae (646 aa), FASTA scores: opt: 3610, E(): 1.2e-205, (88.0% identity in 649 aa overlap). Also highly similar to many GTP-BINDING PROTEINS LEPA e.g. Q9RDC9|LEPA_STRCO|SCC77.29c from Streptomyces coelicolor (622 aa), FASTA scores: opt: 3046, E(): 2.3e-172, (74.3% identity in 626 aa overlap); P37949|LEPA_BACSU from B. subtilis (612 aa), FASTA scores: opt: 2430, E(): 5.3e-136,(58.7% identity in 610 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, LEPA SUBFAMILY. X2BKZ6,P65270 No NC_002945.3 Mycobrowser_v2 CDS 2671338 2671907 . + 0 Mb2428 conserved protein Mb2428, -, len: 189 aa. Equivalent to Rv2405, len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 189 aa overlap). Conserved hypothetical protein, identical (but N-terminus longer 40 residues) to AAK46773|MT2477 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551. Also highly similar, but N-terminus longer 38 residues, to Q9RD03|SCCM1.41 HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 451,E(): 2e-22, (48.7% identity in 154 aa overlap). Shows also similarity with hypothetical proteins from other species. Q7TYN3 No conserved hypotheticals Rv2405 NC_002945.3 Mycobrowser_v2 CDS 2672078 2672506 . - 0 Mb2429c conserved protein Mb2429c, -, len: 142 aa. Equivalent to Rv2406c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein. C-terminal region is identical with many CBS DOMAIN PROTEIN e.g. AAK46774|MT2478 CBS DOMAIN PROTEIN from Mycobacterium tuberculosis strain CDC1551 (aa 47-142), FASTA scores: opt: 594, E(): 1.9e-30, (98.97% identity in 97 aa overlap); etc. Also similar to other hypothetical proteins e.g. AAK24594|CC2626 CBS DOMAIN PROTEIN from Caulobacter crescentus (157 aa), FASTA scores: opt: 377, E(): 8.3e-17, (42.55% identity in 141 aa overlap); BAB47826|MLR0188 from Rhizobium loti; etc. Q7TYN2 No conserved hypotheticals Rv2406c NC_002945.3 Mycobrowser_v2 CDS 2678535 2679485 . - 0 Mb2436c CONSERVED HYPOTHETICAL PROTEIN Mb2436c, -, len: 316 aa. Equivalent to Rv2413c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 316 aa overlap). Conserved hypothetical protein, highly similar to O33133|MLCL536.07c|ML0603|Q49756|G466975|B1937_F2_36 hypothetical 39.1 KDA protein from Mycobacterium leprae (389 aa), FASTA scores: opt: 1683, E(): 1.8e-88, (83.9% identity in 316 aa overlap). ML0603 is a putative lipoprotein with an N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site that is not present in Rv2413c as this seems to be 73 aa shorter. Also some similarity with various proteins from other organisms e.g. Q9RDM2|SCC123.02c PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 792,E(): 6.1e-38, (42.4% identity in 316 aa overlap); Q9HX31|HOLA|PA3989 DNA POLYMERASE III, DELTA SUBUNIT from Pseudomonas aeruginosa (345 aa), FASTA scores: opt: 173,E(): 0.0084, (25.4% identity in 307 aa overlap); etc. Q7TYM7 No conserved hypotheticals Rv2413c NC_002945.3 Mycobrowser_v2 CDS 2672766 2673608 . + 0 Mb2430 conserved hypothetical protein Mb2430, -, len: 280 aa. Equivalent to Rv2407, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(97.5% identity in 280 aa overlap). Conserved hypothetical protein, highly similar (but longer at N-terminus) to AAK46775|MT2479 putative arylsulfatase from Mycobacterium tuberculosis strain CDC1551 (224 aa) FASTA scores: opt: 1433, E(): 2.5e-81, (96.43% identity in 224 aa overlap); O33130|MLCL536.01 HYPOTHETICAL PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 658, E(): 1.5e-33,(56.75% identity in 215 aa overlap). Also similar to AAK23160|CC1176 Metallo-beta-lactamase family protein from Caulobacter crescentus (317 aa), FASTA scores: opt: 286,E(): 1.8e-10, (33% identity in 291 aa overlap). And similar to other hypothetical proteins eg Q49744|B1937_C1_163 HYPOTHETICAL 22.6 KDA PROTEIN (PRECURSOR) from Mycobacterium leprae (211 aa), FASTA scores: opt: 623, E(): 2.1e-31, (56.3% identity in 206 aa overlap); O27859|MTH1831 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (307 aa), FASTA scores: opt: 268, E(): 2.3e-09, (28.35% identity in 307 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 21 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (280 aa versus 273 aa). X2BL26,Q7TYN1 No conserved hypotheticals Rv2407 NC_002945.3 Mycobrowser_v2 CDS 2674201 2674920 . + 0 Mb2431 PE24 possible pe family-related protein pe24 Mb2431, PE24, len: 239 aa. Equivalent to Rv2408,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possibly a member of PE family, similar to AAK46440|MT2159 from Mycobacterium tuberculosis strain CDC1551 (491 aa) FASTA scores: opt: 269, E(): 5.4e-08, (38.45% identity in 156 aa overlap) and AAK45466|MT1209 from Mycobacterium tuberculosis strain CDC1551 (308 aa), FASTA scores: opt: 265, E(): 6.3e-08,(36.0% identity in 197 aa overlap). Q7TYN0 No PE/PPE Rv2408 NC_002945.3 Mycobrowser_v2 CDS 2674678 2675517 . - 0 Mb2432c conserved protein Mb2432c, -, len: 279 aa. Equivalent to Rv2409c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Conserved hypothetical protein, equivalent to Q49757|YP69_MYCLE|G466976|B1937_F2_39 HYPOTHETICAL PROTEIN from Mycobacterium leprae (279 aa), FASTA scores: opt: 1564, E(): 4.6e-95, (82.1% identity in 279 aa overlap). Also similar to others e.g. Q9RSX6|DR1993 from Deinococcus radiodurans (274 aa), FASTA scores: opt: 494, E(): 4e-25,(35.1% identity in 282 aa overlap); BAB49898|Mll2875 from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: opt: 382, E(): 8.9e-18, (29.75% identity in 269 aa overlap); Q9I305|PA1732 from Pseudomonas aeruginosa (266 aa), FASTA scores: opt: 326, E(): 3.7e-14, (31.25% identity in 275 aa overlap); etc. Also similar to Rv2569c|MTCY227.32 from Mycobacterium tuberculosis. Q7TYM9 No conserved hypotheticals Rv2409c NC_002945.3 Mycobrowser_v2 CDS 2675517 2676494 . - 0 Mb2433c conserved protein Mb2433c, -, len: 325 aa. Equivalent to Rv2410c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 325 aa overlap). Conserved hypothetical protein, equivalent to Q49770|CAC30114|ML0606 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (325 aa), FASTA scores: opt: 1928, E(): 3.5e-117, (90.75% identity in 325 aa overlap). Also some similarity with other hypothetical proteins e.g. Q9RST2|DR2041 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (316 aa), FASTA scores: opt: 329, E(): 5.3e-14, (32.4% identity in 318 aa overlap); C-terminus of Q9HUN7|PA4927 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (830 aa),FASTA scores: opt: 297, E(): 1.5e-11, (27.6% identity in 315 aa overlap); etc. Q7TYM8 No conserved hypotheticals Rv2410c NC_002945.3 Mycobrowser_v2 CDS 2676494 2678149 . - 0 Mb2434c CONSERVED HYPOTHETICAL PROTEIN Mb2434c, -, len: 551 aa. Equivalent to Rv2411c,len: 551 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 551 aa overlap). Hypothetical protein,highly similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 HYPOTHETICAL 61.8 KDA PROTEIN from Mycobacterium leprae (561 aa), FASTA scores, opt: 3163, E(): 4.1e-178, (87.35% identity in 554 aa overlap). Also highly similar, except in N-terminus, to others e.g. Q55587|Y335_SYNY3|SLL0335 HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC 6803 (481 aa), FASTA scores: opt: 1620, E(): 1.2e-87,(52.8% identity in 468 aa overlap); Q9I307|PA1730 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (470 aa),FASTA scores: opt: 1574, E(): 5.8e-85, (52.7% identity in 467 aa overlap); Q9RST1|DR2042 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (655 aa), FASTA scores: opt: 1561, E(): 4.4e-84, (53.3% identity in 467 aa overlap); etc. X2BKL7 No conserved hypotheticals Rv2411c NC_002945.3 Mycobrowser_v2 CDS 2678259 2678519 . + 0 Mb2435 rpsT 30s ribosomal protein s20 rpst Mb2435, rpsT, len: 86 aa. Equivalent to Rv2412,len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Probable rpsT, 30s ribosomal protein s20, equivalent to O33132|RS20_MYCLE|L0604|MLCL536.06 30S RIBOSOMAL PROTEIN S20 from Mycobacterium leprae (86 aa), FASTA scores: opt: 456, E(): 4.6e-24, (87.20% identity in 86 aa overlap). Also highly similar or similar to others e.g. Q9RDM3|RPST|SCC123.01 30S RIBOSOMAL PROTEIN S20 from Streptomyces coelicolor (88 aa), FASTA scores: opt: 363,E(): 7.1e-18, (70.95% identity in 86 aa overlap); Q9KD79|RPST|BH1339 RIBOSOMAL PROTEIN S20 (BS20) from Bacillus halodurans (91 aa), FASTA scores: opt: 252, E(): 1.8e-10, (49.4% identity in 85 aa overlap); P02378|RS20_ECOLI 30s ribosomal protein s20 from Escherichia coli (86 aa), FASTA scores: opt: 210, E(): 1e-07, (42.4% identity in 85 aa overlap); etc. BELONGS TO THE S20P FAMILY OF RIBOSOMAL PROTEINS. X2BL34,P66506 No information pathways Rv2412 NC_002945.3 Mycobrowser_v2 CDS 2679490 2681061 . - 0 Mb2437c CONSERVED HYPOTHETICAL PROTEIN Mb2437c, -, len: 523 aa. Similar to Rv2414c, len: 514 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 483 aa overlap). Conserved hypothetical protein, showing some similarity with COME OPERON PROTEINS 3 (COMEC OR COME3) e.g. Q9RTB1|DR1854 PUTATIVE COMPETENCE PROTEIN COMEC/REC2 from Deinococcus radiodurans (755 aa), FASTA scores: opt: 311, E(): 8.2e-11, (27.3% identity in 538 aa overlap); P73100|COME|SLL1929 COME PROTEIN from Synechocystis sp. strain PCC 6803 (709 aa), FASTA scores: opt: 302, E(): 2.6e-10, (26.3% identity in 323 aa overlap) (no similarity on N-terminus); P39695|CME3_BACSU COME OPERON PROTEIN 3 from Bacillus subtilis (776 aa), FASTA scores: opt: 273,E(): 1.4e-08, (25.2% identity in 282 aa overlap) (no similarity on N-terminus); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-t) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (523 aa versus 514 aa). Q7TYM6 No NC_002945.3 Mycobrowser_v2 CDS 2696130 2696429 . - 0 Mb2457c PE25 pe family protein pe25 Mb2457c, PE25, len: 99 aa. Equivalent to Rv2431c,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below), similar to others e.g. AAK47158|MT2839 from Mycobacterium tuberculosis (275 aa) FASTA scores: opt: 194, E(): 2.5e-06, (40.0% identity in 95 aa overlap); etc. Q7TYL3 No NC_002945.3 Mycobrowser_v2 CDS 2923230 2924354 . + 0 Mb2662 conserved protein Mb2662, -, len: 374 aa. Equivalent to Rv2629, len: 374 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 374 aa overlap). Conserved hypothetical protein, similar to Q9ZC00|SC1E6.22c HYPOTHETICAL 40.7 KDA PROTEIN from Streptomyces coelicolor (373 aa), FASTA scores: opt: 425, E(): 2.5e-18, (30.2% identity in 371 aa overlap). Q7TY69 No conserved hypotheticals Rv2629 NC_002945.3 Mycobrowser_v2 CDS 2681076 2681969 . - 0 Mb2438c CONSERVED HYPOTHETICAL PROTEIN Mb2438c, -, len: 297 aa. Equivalent to Rv2415c,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 297 aa overlap). Hypothetical protein,with some similarity in C-terminal part to comE operon proteins 1 e.g. Q9EU10|COME|COME4|COME1|COME2|COME3 COME PROTEIN (a competence protein with DNA-binding activity) from Neisseria gonorrhoeae (99 aa), FASTA scores: opt: 190, E(): 0.0032, (49.2% identity in 61 aa overlap); Q9JYB8|NMB1657 from Neisseria meningitidis (205 aa) FASTA scores: opt: 191, E(): 0.0052, (49.2% identity in 61 aa overlap); CME1_BACSU|P39694 come operon protein 1 from Bacillus subtilis (205 aa), FASTA scores, opt: 181, E(): 0.017 (29.8% identity in 218 aa overlap); etc. Q7TYM5 No conserved hypotheticals Rv2415c NC_002945.3 Mycobrowser_v2 CDS 2682309 2683535 . - 0 Mb2439c eis enhanced intracellular survival protein eis,gcn5-related n-acetyltransferase Mb2439c, -, len: 408 aa. Equivalent to Rv2416c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 408 aa overlap). Conserved hypothetical protein, sharing similarity with Q9F309|SCC80.10 HYPOTHETICAL 44.7 KDA PROTEIN from Streptomyces coelicolor (413 aa), FASTA scores: opt: 382, E(): 1e-16, (31.45% identity in 407 aa overlap); Q9K4F4|SCD66.23 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (418 aa), FASTA scores: opt: 238, E(): 1.3e-07, (36.5% identity in 364 aa overlap): and Q54238|G1139577|ORF5 hypothetical protein from Streptomyces griseus (416 aa), FASTA scores: opt: 237, E(): 1.5e-07, (34.0 identity in 423 aa overlap). X2BKM2,P59772 No virulence, detoxification, adaptation Rv2416c NC_002945.3 Mycobrowser_v2 CDS 2683657 2684499 . - 0 Mb2440c conserved protein Mb2440c, -, len: 280 aa. Equivalent to Rv2417c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to Q9RDL7|SCC123.07c HYPOTHETICAL 29.2 KDA PROTEIN from Streptomyces coelicolor (281 aa), FASTA scores: opt: 579, E(): 3.6e-27, (38.3% identity in 274 aa overlap). Also some similarity with DEGV proteins or hypothetical proteins from other organisms, e.g. Q9RSY3|DR1986 from Deinococcus radiodurans (281 aa), FASTA scores: opt: 393, E(): 3.4e-16, (31.0% identity in 280 aa overlap); P32436|DEGV_BACSU from Bacillus subtilis (281 aa), FASTA scores: opt: 365, E(): 1.5e-14, (27.8% identity in 284 aa overlap); BAB41937|BAB46307|SA0704|SAV0749 Conserved hypothetical protein from Staphylococcus aureus strain Mu50 and N315 (288 aa), FASTA scores: opt: 371, E(): 7e-15, (28.85% identity in 281 aa overlap); etc. X2BL43,P67369 No conserved hypotheticals Rv2417c NC_002945.3 Mycobrowser_v2 CDS 2684580 2685323 . - 0 Mb2441c unknown protein Mb2441c, -, len: 247 aa. Equivalent to Rv2418c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Hypothetical unknown protein. Q7TYM4 No conserved hypotheticals Rv2418c NC_002945.3 Mycobrowser_v2 CDS 2706410 2707849 . - 0 Mb2467c obg PROBABLE GTP1/OBG-FAMILY GTP-BINDING PROTEIN OBG Mb2467c, obg, len: 479 aa. Equivalent to Rv2440c,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Probable obg,nucleotide-binding protein, equivalent to Q9CBZ4|ML1465 GTP1/OBG-FAMILY GTP-BINDING PROTEIN from Mycobacterium leprae (478 aa), FASTA scores: opt: 1328, E(): 8.4e-70,(58.9% identity in 479 aa overlap). Also highly similar to others e.g. P95722|OBG GTP-BINDING PROTEIN from Streptomyces coelicolor (478 aa), FASTA scores: opt: 1311,E(): 8.2e-69, (60.7% identity in 476 aa overlap); P20964|OBG_BACSU SPO0B-ASSOCIATED GTP-BINDING PROTEIN from Bacillus subtilis (428 aa), FASTA scores: opt: 1006, E(): 3.9e-51, (42.9% identity in 436 aa overlap); Q9KDK0|OBG|BH1213 GTP-BINDING PROTEIN INVOLVED IN INITIATION OF SPORULATION from Bacillus halodurans (427 aa), FASTA scores: opt: 978, E(): 1.7e-49, (41.95% identity in 436 aa overlap); etc. Highly similar (identical but shorter 5 aa) to AAK46813|MT2516 GTP-BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551 (484 aa), FASTA scores: opt: 3205, E(): 7.9e-179,(100% identity in 479 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP1/OBG FAMILY. X2BL33,Q7TYK5 No NC_002945.3 Mycobrowser_v2 CDS 2685313 2685984 . - 0 Mb2442c gpgp glucosyl-3-phosphoglycerate phosphatase gpgp Mb2442c, -, len: 223 aa. Equivalent to Rv2419c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 223 aa overlap). Probable phosphoglycerate mutase (EC 5.4.2.1), equivalent to Q9CC00|ML1452 POSSIBLE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (224 aa), FASTA scores: opt: 1206,E(): 8.8e-68, (80.35% identity in 224 aa overlap). Also highly similar to Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 431, E(): 9.4e-20, (40.85% identity in 213 aa overlap); and similar to others e.g. Q9RVD2|DR1097 from Deinococcus radiodurans (232 aa), FASTA scores: opt: 291, E(): 4.6e-11, (39.3% identity in 173 aa overlap); etc. Some similarity to Q10512|Rv2228c|Y019_MYCTU|MT2287|MTcy427.09c hypothetical 39.2 kd protein from Mycobacterium tuberculosis (364 aa) FASTA scores: opt: 196, E(): 2.8e-06, (45.6% identity in 79 aa overlap). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. BELONGS TO THE PHOSPHOGLYCERATE MUTASE FAMILY. Q7TYM3 No intermediary metabolism and respiration Rv2419c NC_002945.3 Mycobrowser_v2 CDS 2686358 2686993 . - 0 Mb2444c nadD PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NICOTINATE MONONUCLEOTIDE ADENYLYLTRANSFERASE) (NAMN ADENYLYLTRANSFERASE) Mb2444c, nadD, len: 211 aa. Equivalent to Rv2421c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). Probable nadD,nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18),equivalent to Q9CBZ8|NADD_MYCLE|ML1454 PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from Mycobacterium leprae (214 aa), FASTA scores: opt: 1125,E(): 2.7e-66, (80.2% identity in 212 aa overlap). Also highly similar to Q9RDK7|NADD_STRCO PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from Streptomyces coelicolor (188 aa), FASTA scores: opt: 855,E(): 9.8e-49, (66.5% identity in 194 aa overlap); and similar to others e.g. P54455|NADD_BACSU from Bacillus subtilis (189 aa), FASTA scores: opt: 351, E(): 7e-16,(36.1% identity in 191 aa overlap); etc. BELONGS TO THE NADD FAMILY. X2BKM6,Q7TYM1 No NC_002945.3 Mycobrowser_v2 CDS 2687268 2687540 . + 0 Mb2445 HYPOTHETICAL PROTEIN Mb2445, -, len: 90 aa. Equivalent to Rv2422, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein. Q7TYM0 No conserved hypotheticals Rv2422 NC_002945.3 Mycobrowser_v2 CDS 2687782 2688828 . + 0 Mb2446 HYPOTHETICAL PROTEIN Mb2446, -, len: 348 aa. Equivalent to Rv2423, len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 348 aa overlap). Hypothetical unknown protein. Q7TYL9 No conserved hypotheticals Rv2423 NC_002945.3 Mycobrowser_v2 CDS 2688961 2689653 . - 0 Mb2447c PROBABLE TRANSPOSASE [SECOND PART] Mb2447c, -, len: 230 aa. Equivalent to 3' end of Rv2424c, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 230 aa overlap). Probable transposase for IS1558, similar to IS element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 1491, E(): 6.2e-87, (98.6% identity in 221 aa overlap); P19780|YIS1_STRCO HYPOTHETICAL INSERTION ELEMENT IS110 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 203, E(): 1.7e-05; (27.3% identity in 238 aa overlap); etc. Contains PS01159 WW/rsp5/WWP domain signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts, Mb2447c and Mb2448c. Q7TYL8 No NC_002945.3 Mycobrowser_v2 CDS 2689667 2689960 . - 0 Mb2448c PROBABLE TRANSPOSASE [FIRST PART] Mb2448c, -, len: 97 aa. Similar to 5' end of Rv2424c, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 67 aa overlap). Probable transposase for IS1558, similar to IS element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 1491, E(): 6.2e-87, (98.6% identity in 221 aa overlap); P19780|YIS1_STRCO HYPOTHETICAL INSERTION ELEMENT IS110 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 203, E(): 1.7e-05; (27.3% identity in 238 aa overlap); etc. Contains PS01159 WW/rsp5/WWP domain signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts, Mb2447c and Mb2448c. Q7TYL7 No NC_002945.3 Mycobrowser_v2 CDS 2690049 2691491 . - 0 Mb2449c CONSERVED HYPOTHETICAL PROTEIN Mb2449c, -, len: 480 aa. Equivalent to Rv2425c,len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Hypothetical protein; C-terminal half shares similarity to other unknown conserved proteins e.g. Q53065 HYPOTHETICAL 24.3 KDA PROTEIN from Rhodococcus erythropolis (219 aa), FASTA scores: opt: 398, E(): 9.9e-17, (34.15% identity in 202 aa overlap); C-terminus of O27843|MTH1815 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (346 aa),FASTA scores: opt: 341, E(): 3.7e-13, (31.35% identity in 233 aa overlap); etc. Q7TYL6 No conserved hypotheticals Rv2425c NC_002945.3 Mycobrowser_v2 CDS 2691491 2692366 . - 0 Mb2450c CONSERVED HYPOTHETICAL PROTEIN Mb2450c, -, len: 291 aa. Equivalent to Rv2426c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 291 aa overlap). Conserved hypothetical protein, highly similar to others e.g. Q51326|ORF4 from Pseudomonas carboxydovorans (295 aa), FASTA scores: opt: 853, E(): 3.7e-43, (48.75% identity in 277 aa overlap); BAB47746|MLR0088 from Rhizobium loti (309 aa), FASTA scores: opt :809, E(): 1.5e-40, (46.5% identity in 291 aa overlap); Q9Y9R8|APE2220 from Aeropyrum pernix (297 aa),FASTA scores: opt: 763, E(): 7.4e-38, (47.1% identity in 261 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TYL5 No conserved hypotheticals Rv2426c NC_002945.3 Mycobrowser_v2 CDS 4029078 4030115 . + 0 Mb3675 CONSERVED HYPOTHETICAL PROTEIN Mb3675, -, len: 345 aa. Equivalent to Rv3651, len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 345 aa overlap). Hypothetical protein,with some similarity to Q9ZHK1 HYPOTHETICAL 36.5 KDA PROTEIN from Rhodococcus sp. X309 (329 aa) FASTA scores: opt: 332, E(): 3.4e-13, (27.4% identity in 321 aa overlap). Q7TW12 No conserved hypotheticals Rv3651 NC_002945.3 Mycobrowser_v2 CDS 2696600 2697010 . - 0 Mb2458c HYPOTHETICAL PROTEIN Mb2458c, -, len: 136 aa. Equivalent to Rv2432c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Hypothetical unknown protein. Q7TYL2 No conserved hypotheticals Rv2432c NC_002945.3 Mycobrowser_v2 CDS 2697007 2697297 . - 0 Mb2459c HYPOTHETICAL PROTEIN Mb2459c, -, len: 96 aa. Equivalent to Rv2433c, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Hypothetical unknown protein. Q7TYL1 No conserved hypotheticals Rv2433c NC_002945.3 Mycobrowser_v2 CDS 2692393 2693640 . - 0 Mb2451c proA PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDEHYDE DEHYDROGENASE) Mb2451c, proA, len: 415 aa. Equivalent to Rv2427c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Probable proA,gamma-glutamyl phosphate reductase protein (EC 1.2.1.41),equivalent to Q9CBZ7|ML1458|PROA [GAMMA]-GLUTAMYL PHOSPHATE REDUCTASE from Mycobacterium leprae (409 aa),FASTA scores: opt: 2120, E(): 7.4e-118, (81.9% identity in 409 aa overlap). Also highly similar or similar to other GAMMA-GLUTAMYL PHOSPHATE REDUCTASES PROTEINS (GPR) e.g. Q9RDK1|PROA from Streptomyces coelicolor (428 aa), FASTA scores: opt: 1073, E(): 4.6e-56, (60.4% identity in 429 aa overlap); P45638|PROA_CORGL from Corynebacterium glutamicum (432 aa), FASTA scores: opt: 993, E(): 2.4e-51,(58.5% identity in 417 aa overlap); P96489|PROA_STRTR GAMMA-GLUTAMYL PHOSPHATE REDUCTASE from Streptococcus thermophilus (416 aa), FASTA scores: opt: 863, E(): 1.1e-43, (49.15% identity in 413 aa overlap); etc. BELONGS TO THE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE FAMILY. X2BKG4,P65789 No NC_002945.3 Mycobrowser_v2 CDS 2707935 2708195 . - 0 Mb2468c rpmA 50s ribosomal protein l27 rpma Mb2468c, rpmA, len: 86 aa. Equivalent to Rv2441c,len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Probable rpmA, 50S RIBOSOMAL PROTEINS L27, equivalent to Q9CBZ3|RL27_MYCLE from Mycobacterium leprae (88 aa), FASTA scores: opt: 504,E(): 7.6e-28, (93.2% identity in 81 aa overlap). Also highly similar to others e.g. P95757|RL27_STRGR from Streptomyces griseus (85 aa), FASTA scores: opt: 442, E(): 1.2e-23, (81.5% identity in 81 aa overlap); etc. Contains PS00831 Ribosomal protein L27 signature. BELONGS TO THE L27P FAMILY OF RIBOSOMAL PROTEINS. X2BKU6,P66128 No NC_002945.3 Mycobrowser_v2 CDS 2694356 2694943 . + 0 Mb2454 ahpC ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C) Mb2454, ahpC, len: 195 aa. Equivalent to Rv2428,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). ahpC, alkyl hydroperoxide reductase C (EC 1.-.-.-) (see citations below), equivalent to other alkyl hydroperoxide reductases C mycobacterial proteins e.g. Q9CBF5|AHPC|ML2042 ALKYL HYDROPEROXIDE REDUCTASE from Mycobacterium leprae (195 aa) FASTA scores: opt: 1183, E(): 2.6e-72, (88.20% identity in 195 aa overlap); O87323|AHPC from Mycobacterium marinum (195 aa), FASTA scores: opt: 1215, E(): 1.9e-74, (90.8% identity in 195 aa overlap); Q57413|AHPC|AVI-3 from Mycobacterium avium (195 aa), FASTA scores: opt: 1201,E(): 1.6e-73, (90.25% identity in 195 aa overlap). Also highly similar to others from other organisms e.g. Q9FBP5|AHPC ALKYL HYDROPEROXIDE REDUCTASE from Streptomyces coelicolor (184 aa), FASTA scores: opt: 768,E(): 1.7e-44, (62.45% identity in 189 aa overlap); etc. I3NIF4 No virulence, detoxification, adaptation Rv2428 NC_002945.3 Mycobrowser_v2 CDS 2694969 2695502 . + 0 Mb2455 ahpD ALKYL HYDROPEROXIDE REDUCTASE D PROTEIN AHPD (ALKYL HYDROPEROXIDASE D) Mb2455, ahpD, len: 177 aa. Equivalent to Rv2429,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). ahpD, alkyl hydroperoxide reductase (EC 1.-.-.-), similar to other alkyl hydroperoxide reductases D proteins e.g. Q9RN73|AHPD from Streptomyces coelicolor (178 aa), FASTA scores: opt: 611, E(): 1.4e-33, (57.4% identity in 169 aa overlap); Q50441|AHPD_MYCSM AHPD PROTEIN (FRAGMENT) from Mycobacterium smegmatis (52 aa), FASTA score: opt:196. X2BL65,P0A5N5 No virulence, detoxification, adaptation Rv2429 NC_002945.3 Mycobrowser_v2 CDS 2695499 2696083 . - 0 Mb2456c PPE41 ppe family protein ppe41 Mb2456c, PPE41, len: 194 aa. Equivalent to Rv2430c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 194 aa overlap). Member of the Mycobacterium tuberculosis PPE family similar to others e.g. AAK46014|Rv1745|MT1745 from Mycobacterium tuberculosis (385 aa) FASTA scores: opt: 389, E(): 1.2e-17, (35.95% identity in 192 aa overlap); etc. Q7TYL4 No NC_002945.3 Mycobrowser_v2 CDS 2708210 2708524 . - 0 Mb2469c rplU 50s ribosomal protein l21 rplu Mb2469c, rplU, len: 104 aa. Equivalent to Rv2442c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable rplU, 50S RIBOSOMAL PROTEIN L21, equivalent to Q9CBZ2|RL21_MYCLE from Mycobacterium leprae (103 aa), FASTA scores: opt: 579, E(): 4.8e-31, (91.1% identity in 102 aa overlap). Also highly similar to others e.g. P95756|RL21_STRGR from Streptomyces griseus (106 aa), FASTA scores: opt: 362,E(): 5.4e-17, (56.0% identity in 100 aa overlap); etc. X2BKR3,P66118 No NC_002945.3 Mycobrowser_v2 CDS 2697278 2698723 . - 0 Mb2460c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2460c, -, len: 481 aa. Equivalent to Rv2434c,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 481 aa overlap). Probable conserved transmembrane protein, with some similarity to BAB48444|MLR0973 PROBABLE INTEGRAL MEMBRANE PROTEIN from Rhizobium loti (410 aa), FASTA scores: opt: 298, E(): 4.1e-11, (27.25% identity in 389 aa overlap); and also similarity with other hypothetical proteins and/or putative integral membrane proteins. Q7TYL0 No cell wall and cell processes Rv2434c NC_002945.3 Mycobrowser_v2 CDS 2698720 2700912 . - 0 Mb2461c probable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-) Mb2461c, -, len: 730 aa. Equivalent to Rv2435c,len: 730 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 730 aa overlap). Probably a cyclase (adenylyl- or guanylyl-cyclase; EC 4.6.1.1 or 4.6.1.2 respectively); C-terminal domain (aa 500-730) similar to domain at C-terminus of a series of adenylate/guanylate cyclases (EC 4.6.-.-) e.g. O30820|CYA AAK45931|MT1661 from Mycobacterium tuberculosis (443 aa) FASTA scores: opt: 446, E(): 1.3e-19, (30.55% identity in 301 aa overlap); BAB50179|MLL3242 CYCLASE (ADENYLYL OR GUANYLYL) from Rhizobium loti (356 aa), FASTA scores: opt: 372, E(): 3.4e-15, (28.75% identity in 219 aa overlap); etc. BELONGS TO ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY. Q7TYK9 No intermediary metabolism and respiration Rv2435c NC_002945.3 Mycobrowser_v2 CDS 2701393 2702307 . + 0 Mb2462 rbsK RIBOKINASE RBSK Mb2462, rbsK, len: 304 aa. Equivalent to Rv2436,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 304 aa overlap). Probable rbsK,ribokinase (EC 2.7.1.15), similar to others e.g. Q9RZ99|DRA0055 from Deinococcus radiodurans (300 aa) FASTA scores: opt: 485, E(): 9.1e-21, (44.55% identity in 301 aa overlap); P36945|P96733|RBSK_BACSU from Bacillus subtilis (293 aa), FASTA scores: opt: 398, E(): 8.5e-16, (36.35% identity in 297 aa overlap); P05054|RBSK_ECOLI|B3752|Z5253|ECS4694 from Escherichia coli strain K12 (309 aa), FASTA scores: opt: 387, E(): 3.8e-15, (34.7% identity in 314 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. BELONGS TO THE PFKB FAMILY OF CARBOHYDRATE KINASES. Q7TYK8 No intermediary metabolism and respiration Rv2436 NC_002945.3 Mycobrowser_v2 CDS 2702539 2702958 . + 0 Mb2463 conserved transmembrane protein Mb2463, -, len: 139 aa. Equivalent to Rv2437, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, with some similarity to CONSERVED HYPOTHETICAL PROTEINS e.g. O06539|RV1139C|MTCI65.06c from Mycobacterium tuberculosis (166 aa); AAK45430|MT1172 from Mycobacterium tuberculosis (124 aa), FASTA scores: opt: 166, E(): 0.00013, (35.7% identity in 112 aa overlap); BAB48937|Mlr1600 from Rhizobium loti (222 aa), FASTA scores: opt: 163 ,E(): 0.00033, (28.1% identity in 121 aa overlap); etc. Q7TYK7 No cell wall and cell processes Rv2437 NC_002945.3 Mycobrowser_v2 CDS 2726371 2727651 . - 0 Mb2484c clpX PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX Mb2484c, clpX, len: 426 aa. Equivalent to Rv2457c,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 426 aa overlap). Probable clpX,ATP-dependent clp protease ATP-binding subunit clpX (EC 3.4.-.-), equivalent to Q9CBY6|CLPX|ML1477 ATP-DEPENDENT CLP PROTEASE ATP-BINDING PROTEIN from Mycobacterium leprae (426 aa), FASTA scores: opt: 2652, E(): 1.4e-142, (96.0% identity in 426 aa overlap). Also highly similar to others e.g. Q9F316|CLPX from Streptomyces coelicolor (428 aa) FASTA scores: opt: 2178, E(): 8.2e-116, (77.8% identity in 428 aa overlap); P50866|CLPX_BACSU from Bacillus subtilis (420 aa), FASTA scores: opt: 1788, E(): 8.5e-94, (63.6% identity in 426 aa overlap); P33138|CLPX_ECOLI from Escherichia coli (423 aa), FASTA scores: opt: 1694, E(): 1.7e-88, (62.4% identity in 415 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CLPX CHAPERONE FAMILY. X2BKU9,P0A529 No NC_002945.3 Mycobrowser_v2 CDS 2702955 2704994 . - 0 Mb2464c nadE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) Mb2464c, nadE, len: 679 aa. Equivalent to Rv2438c,len: 679 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 679 aa overlap). nadE,glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (see citation below), equivalent to Q9CBZ6|NADE_MYCLE|ML1463 Glutamine-dependent NAD(+) synthetase from Mycobacterium leprae (680 aa), FASTA scores: opt: 3877, E(): 0. Also similar to others e.g. O83759|NADE_TREPA|TP0780 from Treponema pallidum (679 aa), FASTA scores: opt: 543, E(): 1.1e-25; O74940|NADE_SCHPO|SPCC553.02 from Schizosaccharomyces pombe (Fission yeast) (700 aa), FASTA scores: opt: 354, E(): 4.7e-14 ; P38795|NADE_YEAST|YHR074W from Saccharomyces cerevisiae (Baker's yeast) (714 aa),FASTA scores: opt: 339, E(): 4e-13; etc. Contains PS00591 Glycosyl hydrolases family 10 active site. BELONGS TO THE NAD SYNTHETASE FAMILY IN THE C-TERMINAL SECTION. N-terminus shorter since first submission. X2BKQ4,P0A5L7 No NC_002945.3 Mycobrowser_v2 CDS 2704872 2705150 . + 0 Mb2465 CONSERVED HYPOTHETICAL PROTEIN Mb2465, -, len: 92 aa. Equivalent to Rv2438A, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Conserved hypothetical protein, showing few similarity with various enzymes e.g. part of O83441|VAA1_TREPA|ATPA1|TP0426 V-TYPE ATP SYNTHASE ALPHA CHAIN 1 (EC 3.6.1.34) from Treponema pallidum (589 aa), FASTA scores: opt: 110, E(): 1.5, (40.3% identity in 72 aa overlap); N-terminus of O95178|NIGM_HUMAN NADH-UBIQUINONE OXIDOREDUCTASE AGGG SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) from Homo sapiens (105 aa), FASTA scores: opt: 109, E(): 1.5, (35.5% identity in 62 aa overlap); N-terminus of Q9HJ76|TA1096 PROBABLE GLYCEROL KINASE from Thermoplasma acidophilum (488 aa); etc. Q7TYK6 No conserved hypotheticals Rv2438A NC_002945.3 Mycobrowser_v2 CDS 2725099 2726355 . - 0 Mb2483c probable conserved integral membrane transport protein Mb2483c, -, len: 418 aa. Equivalent to Rv2456c,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 418 aa overlap). Probable conserved integral membrane transport protein, involved in a efflux system, weakly similar to many e.g. Q9RUR0|YD22_DEIRA|DR1322 PUTATIVE SUGAR EFFLUX TRANSPORTER from Deinococcus radiodurans (389 aa), FASTA scores: opt: 224, E(): 8.4e-06, (24.45% identity in 409 aa overlap); Q9UYY0|PAB0913 MULTIDRUG RESISTANCE PROTEIN from Pyrococcus abyssi (410 aa), FASTA scores: opt: 210, E(): 5.6e-05, (21.8% identity in 408 aa overlap); etc. Contains PS00216 Sugar transport proteins signature 1. Q7TYJ4 No cell wall and cell processes Rv2456c NC_002945.3 Mycobrowser_v2 CDS 2705280 2706410 . - 0 Mb2466c proB PROBABLE GLUTAMATE 5-KINASE PROTEIN PROB (GAMMA-GLUTAMYL KINASE) (GK) Mb2466c, proB, len: 376 aa. Equivalent to Rv2439c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 376 aa overlap). Probable proB,glutamate 5-kinase protein (GK) (EC 2.7.2.11), equivalent to Q9CBZ5|PROB|ML1464 from Mycobacterium leprae (367 aa) FASTA scores: opt: 1937, E(): 1.1e-102, (84.4% identity in 366 aa overlap). Also highly similar to other glutamate 5-kinase proteins e.g. P46546|PROB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (369 aa), FASTA scores: opt: 1241, E(): 3e-63, (54.35% identity in 368 aa overlap); Q9ZG98|PROB_MEIRU GLUTAMATE 5-KINASE from Meiothermus ruber (390 aa), FASTA scores: opt: 825,E(): 1.2e-39, (45.05% identity in 353 aa overlap); Q9RDJ9|PROB|SCC123.25c from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1193, E(): 1.6e-60, (55.85% identity in 367 aa overlap); etc. Contains PS00902 Glutamate 5-kinase signature. BELONGS TO THE GLUTAMATE 5-KINASE FAMILY. X2BKI0,P59958 No NC_002945.3 Mycobrowser_v2 tRNA 2733704 2733774 . + 0 glyV glyV tRNA-Gly glyV, len: 71 nt. Equivalent to glyV, len: 71 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 nt overlap). tRNA-Gly; anticodon tcc. No NC_002945.3 Mycobrowser_v2 CDS 2708872 2710347 . + 0 Mb2470 dctA PROBABLE C4-DICARBOXYLATE-TRANSPORT TRANSMEMBRANE PROTEIN DCTA Mb2470, dctA, len: 491 aa. Equivalent to Rv2443,len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 491 aa overlap). Probable dctA,C4-dicarboxylate-transport transmembrane protein, similar to other C4-DICARBOXYLATE TRANSPORT PROTEINS e.g. AAK46817|MT2519 from Mycobacterium tuberculosis strain CDC1551 (491 aa); Q9L1K8|SC6A11.12 PUTATIVE SODIUM:DICARBOXYLATE SYMPORTER from Streptomyces coelicolor (466 aa), FASTA scores: opt: 1797, E(): 2.9e-98, (61.3% identity in 452 aa overlap); Q9RRG7|DR2525 from Deinococcus radiodurans (463 aa); P50334|DCTA_SALTY from Salmonella typhimurium (428 aa) FASTA scores: opt: 1241, E(): 1.3e-65, (47.2% identity in 415 aa overlap); etc. BELONGS TO THE SODIUM DICARBOXYLATE SYMPORTER FAMILY (SDF) (DAACS FAMILY). Q7TYK4 No cell wall and cell processes Rv2443 NC_002945.3 Mycobrowser_v2 CDS 2731335 2731937 . - 0 Mb2488c clpP1 PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Mb2488c, clpP1, len: 200 aa. Equivalent to Rv2461c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Probable clpP1,ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92), equivalent to Q9CBY3|CLP1_MYCLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT from Mycobacterium leprae (224 aa), FASTA scores: opt: 1226, E(): 1.3e-71, (95.0% identity in 200 aa overlap). Also highly similar to others e.g. Q9F315|CLPP1 from Streptomyces coelicolor (219 aa),FASTA scores: opt: 713, E(): 9.3e-39, (61.75% identity in 183 aa overlap); P80244|CLPP_BACSU from Bacillus subtilis (197 aa), FASTA scores: opt: 658, E(): 2.8e-35, (54% identity in 187 aa overlap); Q9WZF9|CLPP_THEMA|TM0695 from Thermotoga maritima (203 aa), FASTA scores: opt: 653, E(): 6.1e-35, (55.25% identity in 172 aa overlap); etc. Also similar to downstream ORF Rv2460c|MTV008.16c|clpP2 (214 aa), FASTA score: (48.3% identity in 172 aa overlap). BELONGS TO PEPTIDASE FAMILY S14, ALSO KNOWN AS CLPP FAMILY. Note that previously known as clp. X2BKX6,P0A527 No NC_002945.3 Mycobrowser_v2 CDS 2710286 2713147 . - 0 Mb2471c rne POSSIBLE RIBONUCLEASE E RNE Mb2471c, rne, len: 953 aa. Equivalent to Rv2444c,len: 953 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 953 aa overlap). Possible rne,ribonuclease E (EC 3.1.-.-), highly similar to others e.g. Q9CBZ1|ML1468 POSSIBLE RIBONUCLEASE from Mycobacterium leprae (924 aa), FASTA scores: opt: 3713, E(): 2.4e-174,(74.2% identity in 966 aa overlap); Q9SI08|AT2G04270 PUTATIVE RIBONUCLEASE E from Arabidopsis thaliana (502 aa), FASTA scores: opt: 674, E(): 7.5e-26, (31.2% identity in 410 aa overlap); etc. Similar at C-terminal end to P21513|RNE_ECOLI|AMS|HMP1|B1084 ribonuclease E (EC 3.1.4.-) (RNASE E) from Escherichia coli strain K12 (1061 aa), FASTA scores: opt: 554, E(): 9.9e-20, (37.8% identity in 386 aa overlap). Also similar in medium part to several cytoplasmic axial filament proteins e.g. Q9HVU4|CAFA|PA4477 from Pseudomonas aeruginosa (485 aa),FASTA scores: opt: 664, E(): 2.3e-25, (42.8% identity in 418 aa overlap); etc. Equivalent to AAK46818 from Mycobacterium tuberculosis strain CDC1551 (621 aa) but longer 332 aa in N-terminal part. SEEMS TO BELONG TO THE RNE FAMILY. Q7TYK3 No NC_002945.3 Mycobrowser_v2 CDS 2761152 2761922 . + 0 Mb2511 echA14 PROBABLE ENOYL-COA HYDRATASE ECHA14 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb2511, echA14, len: 256 aa. Equivalent to Rv2486,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable echA14,enoyl-coA hydratase (EC 4.2.1.17), similar to others e.g. P24162|ECHH_RHOCA2|FADB1 from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores; opt: 453, E(): 3.8e-23, (39.4% identity in 259 aa overlap); Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa), FASTA scores: opt: 404, E(): 5.7e-17, (37.5% identity in 224 aa overlap); P77467|PAAG_ECOLI from Escherichia coli (262 aa), FASTA scores: opt: 401, E(): 8.3e-17, (36.3% identity in 259 aa overlap); etc. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. X2BL76,P64019 No NC_002945.3 Mycobrowser_v2 CDS 2713477 2713887 . - 0 Mb2472c ndkA PROBABLE NUCLEOSIDE DIPHOSPHATE KINASE NDKA (NDK) (NDP KINASE) (NUCLEOSIDE-2-P KINASE) Mb2472c, ndkA, len: 136 aa. Equivalent to Rv2445c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Probable ndkA (alternate gene name: ndk), nucleoside diphosphate kinase (EC 2.7.4.6), equivalent to Q9CBZ0|NDK|ML1469 from Mycobacterium leprae (136 aa), FASTA scores: opt: 762,E(): 1.5e-42, (87.4% identity in 135 aa overlap); and O85501|NDK from Mycobacterium smegmatis (139 aa), FASTA scores: opt: 714, E(): 1.9e-39, (80.7% identity in 135 aa overlap). Also highly similar to others e.g. P50589|NDK_STRCO from Streptomyces coelicolor (137 aa),FASTA scores: opt: 535, 6.8e-28, (60.3% identity in 136 aa overlap); O29491|NDK_ARCFU|AF0767 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 521, E(): 5.9e-27,(58.0% identity in 131 aa overlap); P31103|NDK_BACSU from Bacillus subtilis (151 aa), FASTA scores: opt: 515, E(): 1.4e-26, (56.5% identity in 131 aa overlap); etc. BELONGS TO THE NDK FAMILY. X2BL38,P84283 No NC_002945.3 Mycobrowser_v2 CDS 2744479 2745132 . - 0 Mb2501c CONSERVED HYPOTHETICAL PROTEIN Mb2501c, -, len: 217 aa. Equivalent to Rv2474c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Hypothetical protein. Shows weak similarity with Q9L246|SC6D10.18c HYPOTHETICAL 24.9 KDA PROTEIN from Streptomyces coelicolor (238 aa),FASTA scores: opt: 111, E(): 5.6, (30% identity in 233 aa overlap), BLASTP scores: Score= 135, E= 3.5e-07, P= 3.5e-07, Identities= 55/182 (30%). Q7TYI1 No conserved hypotheticals Rv2474c NC_002945.3 Mycobrowser_v2 tRNA 2937404 2937475 . + 0 valU valU tRNA-Val valU, len: 72 nt. Equivalent to valU, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Val, anticodon gac. No NC_002945.3 Mycobrowser_v2 CDS 2713930 2714301 . - 0 Mb2473c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2473c, -, len: 123 aa. Equivalent to Rv2446c,len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 123 aa overlap). Probable conserved integral membrane protein, highly similar to Q9CBY9|ML1470 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (123 aa), FASTA scores: opt: 468, E(): 6.7e-23, (66.65% identity in 108 aa overlap). Also similar to Q9L1G5|SCC88.24c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (118 aa), FASTA scores: opt: 130,E(): 0.13, (37.2% identity in 86 aa overlap); and some similarity to O06852|Y13070 hypothetical Streptomyces coelicolor gene also between fpgs and ndk genes (see citation below) (117 aa), FASTA scores: opt: 128, E(): 0.17, (36.0% identity in 86 aa overlap). Q7TYK2 No cell wall and cell processes Rv2446c NC_002945.3 Mycobrowser_v2 CDS 2714298 2715761 . - 0 Mb2474c folC PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) Mb2474c, folC, len: 487 aa. Equivalent to Rv2447c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 487 aa overlap). Probable folC,folylpolyglutamate synthase (EC 6.3.2.17), equivalent to Q9CBY8|FOLC|ML1471 from Mycobacterium leprae (485 aa),FASTA scores: opt: 2425, E(): 2.2e-134, (78.7% identity in 483 aa overlap). Also highly similar to others e.g. Q9L1G4|FPGS|O08416|Y13070 from Streptomyces coelicolor (444 aa), FASTA scores: opt: 774, E(): 6.3e-38, (53.9% identity in 462 aa overlap); P15925|FOLC_LACCA|FGS from Lactobacillus casei (428 aa), FASTA scores: opt: 631, E(): 1.4e-29, (34.55% identity in 437 aa overlap); Q05865|FOLC_BACSU from Bacillus subtilis (430 aa), FASTA scores: opt: 421, E(): 2.6e-17, (32.9% identity in 383 aa overlap); etc. Contains PS01012 Folylpolyglutamate synthase signature 2. BELONGS TO THE FOLYLPOLYGLUTAMATE SYNTHASE FAMILY. Q7TYK1 No NC_002945.3 Mycobrowser_v2 CDS 2715758 2718388 . - 0 Mb2475c valS PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) Mb2475c, valS, len: 876 aa. Equivalent to Rv2448c,len: 876 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 876 aa overlap). Probable valS,valyl-tRNA synthetases (EC 6.1.1.9), equivalent to Q9CBY7|VALS|ML1472 VALYL-TRNA SYNTHASE from Mycobacterium leprae (886 aa), FASTA scores: opt: 5181,E(): 0, (85.4% identity in 876 aa overlap). Also highly similar to others e.g. O06851|SYV_STRCO from Streptomyces coelicolor (874 aa), FASTA scores: opt: 2470, E(): 1.6e-143, (60.45% identity in 880 aa overlap); Q9X2D7|SYV_THEMA|VALS|TM1817 from Thermotoga maritima (865 aa), FASTA scores: opt: 2418, E(): 2.4e-140, (44.2% identity in 891 aa overlap); Q05873|SYV_BACSU|VALS from Bacillus subtilis (880 aa),FASTA scores: opt: 2063, E(): 1.4e-118, (46.08% identity in 894 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Contains probable coiled-coil from aa 810 to 846. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. X2BLE0,P67600 No NC_002945.3 Mycobrowser_v2 CDS 2719825 2720343 . - 0 Mb2477c rpfE PROBABLE RESUSCITATION-PROMOTING FACTOR RPFE Mb2477c, rpfE, len: 172 aa. Equivalent to Rv2450c,len: 172 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 172 aa overlap). Probable rpfE,resuscitation-promoting factor (see first citation below),similar to O86308|Z96935|MLRPF_1 RPF PROTEIN PRECURSOR from Micrococcus luteus (220 aa), FASTA scores: opt: 291,E(): 3e-7, (48.75% identity in 80 aa overlap). C-terminus is similar to other Mycobacterial rpf proteins e.g. O05594|Rv1009|MTCI237.26|RPFB PROBABLE RESUSCITATION-PROMOTING FACTOR from Mycobacterium tuberculosis (362 aa), FASTA scores: opt: 344, E(): 1.4e-09, (42.85% identity in 147 aa overlap); etc. C-terminal region similar to N-terminal region of Q9F2Q2|SCE41.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 355,E(): 3.1e-10, (56.65% identity in 90 aa overlap). Also similar to Q9F2Q1|SCE41.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (near Q9F2Q2|SCE41.06c) (341 aa) FASTA scores: opt: 317, E(): 2.5e-08, (51.7% identity in 87 aa overlap). With Mycobacterium leprae, high similarity between the two corresponding C-terminal regions of two HYPOTHETICAL PROTEINS, Q9CD53|ML0240 (375 aa), FASTA scores: opt: 339, E(): 2.5e-09, (59.15% identity in 93 aa overlap) and O33049|MLCB57.05c|ML2151 (174 aa), FASTA scores: opt: 329, E(): 4e-09, (58.14% identity in 86 aa overlap). Contains a possible secretory signal sequence in N-terminus. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citation below). Q7TYJ9 No NC_002945.3 Mycobrowser_v2 CDS 2720425 2720823 . + 0 Mb2478 HYPOTHETICAL PROLINE AND SERINE RICH PROTEIN Mb2478, -, len: 132 aa. Equivalent to Rv2451, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 132 aa overlap). Hypothetical unknown pro-, ser-rich protein. Q7TYJ8 No conserved hypotheticals Rv2451 NC_002945.3 Mycobrowser_v2 CDS 2721011 2721157 . - 0 Mb2479c HYPOTHETICAL PROTEIN Mb2479c, -, len: 48 aa. Equivalent to Rv2452c, len: 48 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 48 aa overlap). Hypothetical unknown protein. Q7TYJ7 No conserved hypotheticals Rv2452c NC_002945.3 Mycobrowser_v2 CDS 2721181 2721786 . - 0 Mb2480c mobA PROBABLE MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A MOBA Mb2480c, mobA, len: 201 aa. Equivalent to Rv2453c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable mobA,molybdopterin-guanine dinucleotide biosynthesis protein A,similar to others e.g. Q9F8G7 from Carboxydothermus hydrogenoformans (224 aa), FASTA scores: opt: 249, E(): 3.9e-08, (30.6% identity in 173 aa overlap); P95645|MOBA_RHOSH|MOB|Y09560 from Rhodobacter sphaeroides (199 aa), FASTA scores: opt: 240, E(): 1.2e-07, (33.9% identity in 186 aa overlap); Q9X7K0|MOBA_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (191 aa), FASTA scores: opt: 217, E(): 2.9e-06, (37.4% identity in 123 aa overlap); etc. BELONGS TO THE MOBA FAMILY. X2BLF3,P65403 No NC_002945.3 Mycobrowser_v2 CDS 3728008 3728400 . - 0 Mb3399c conserved protein Mb3399c, -, len: 130 aa. Equivalent to Rv3364c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Conserved hypothetical protein, highly similar to others from Streptomyces coelicolor e.g. O86524|SC1C2.24c (137 aa),FASTA scores: opt: 466, E(): 1.3e-22, (58.6% identity in 116 aa overlap); O86521|SC1C2.20c (140 aa), FASTA scores: opt: 445, E(): 2.7e-21, (56.9% identity in 116 aa overlap); Q9KZI6|SCG8A.13c (145 aa), FASTA scores: opt: 341, E(): 9.5e-15, (51.3% identity in 113 aa overlap); etc. Q7TWM4 No conserved hypotheticals Rv3364c NC_002945.3 Mycobrowser_v2 CDS 2721788 2722909 . - 0 Mb2481c PROBABLE OXIDOREDUCTASE (BETA SUBUNIT) Mb2481c, -, len: 373 aa. Equivalent to Rv2454c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Probable oxidoreductase, beta subunit (EC 1.-.-.-), similar to Q9F2W7|SCD20.12c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (352 aa), FASTA scores: opt: 1461, E(): 6.4e-85, (65.3% identity in 343 aa overlap) alias Q9RKS5|STAH10.34c PUTATIVE OXIDOREDUCTASE BETA-SUBUNIT from Streptomyces coelicolor (350 aa), FASTA scores: opt: 1429, E(): 6.7e-83, (64.0% identity in 342 aa overlap); and similar in part to others e.g. Q9Z5X3 FERREDOXIN OXIDOREDUCTASE B-SUBUNIT from Frankia sp. (346 aa), FASTA scores: opt: 1143, E(): 7.5e-65, (51.2% identity in 336 aa overlap); BAB21495|KORB FERREDOXIN OXIDOREDUCTASE BETA SUBUNIT from Hydrogenobacter thermophilus TK-6 (295 aa),FASTA scores: opt: 682, E(): 8.3e-36, (48.25% identity in 201 aa overlap); etc. Note that the upstream ORF (MTV008.11c|Rv2455c) is possibly an oxidoreductase alpha subunit. Q7TYJ6 No intermediary metabolism and respiration Rv2454c NC_002945.3 Mycobrowser_v2 CDS 2722906 2724867 . - 0 Mb2482c PROBABLE OXIDOREDUCTASE (ALPHA SUBUNIT) Mb2482c, -, len: 653 aa. Equivalent to Rv2455c,len: 653 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 653 aa overlap). Probable oxidoreductase, alpha subunit (EC 1.-.-.-), similar to others e.g. Q9F2W6|SCD20.13c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (645 aa), FASTA scores: opt: 2017,E(): 1e-111, (66.45% identity in 617 aa overlap) alias Q9RKS4|STAH10.35c PUTATIVE OXIDOREDUCTASE ALPHA-SUBUNIT from Streptomyces coelicolor (630 aa), FASTA scores: opt: 2008, E(): 3.4e-111, (66.45% identity in 614 aa overlap); Q9YA13|APE2126 LONG HYPOTHETICAL 2-OXOACID--FERREDOXIN OXIDOREDUCTASE ALPHA CHAIN from Aeropyrum pernix (644 aa) FASTA scores: opt: 687, E(): 4.6e-33, (33.35% identity in 441 aa overlap); etc. Note that the downstream ORF (MTV008.10c|Rv2454c) is possibly an oxidoreductase beta subunit. Q7TYJ5 No intermediary metabolism and respiration Rv2455c NC_002945.3 Mycobrowser_v2 CDS 3727662 3728030 . - 0 Mb3398c CONSERVED HYPOTHETICAL PROTEIN Mb3398c, -, len: 122 aa. Equivalent to Rv3363c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Conserved hypothetical protein, similar to others from Streptomyces coelicolor e.g. O86523|SC1C2.23c (132 aa), FASTA scores: opt: 236, E(): 9e-09, (38.5% identity in 122 aa overlap); O86520|SC1C2.19c (190 aa), FASTA scores: opt: 231, E(): 2.7e-08, (41.0% identity in 122 aa overlap); Q9X834|SC9B1.14c (119 aa), FASTA scores: opt: 188, E(): 1.1e-05, (37.5% identity in 120 aa overlap); Q9ADJ4|SCBAC14E8.05 (113 aa), FASTA scores: opt: 167, E(): 0.00025, (33.05% identity in 109 aa overlap); etc. Q7TWM5 No conserved hypotheticals Rv3363c NC_002945.3 Mycobrowser_v2 CDS 2753377 2753700 . - 0 Mb2506c HYPOTHETICAL PROTEIN Mb2506c, -, len: 107 aa. Equivalent to Rv2481c,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 107 aa overlap). Hypothetical unknown protein. Q7TYH6 No conserved hypotheticals Rv2481c NC_002945.3 Mycobrowser_v2 CDS 2727942 2728850 . + 0 Mb2485 mmuM PROBABLE HOMOCYSTEINE S-METHYLTRANSFERASE MMUM (S-METHYLMETHIONINE:HOMOCYSTEINE METHYLTRANSFERASE) (CYSTEINE METHYLTRANSFERASE) Mb2485, mmuM, len: 302 aa. Equivalent to Rv2458,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Probable mmuM,homocysteine S-methyltransferase (EC 2.1.1.10), equivalent to Q9CBY5|ML1478 POSSIBLE TRANSFERASE from Mycobacterium leprae (293 aa), FASTA scores: opt: 1507, E(): 2.7e-86,(78.85% identity in 293 aa overlap). Also similar to others e.g. Q47690|MMUM_ECOLI|B0261 HOMOCYSTEINE S-METHYLTRANSFERASE from Escherichia coli strain K12 (310 aa), FASTA scores: opt: 863, E(): 2.4e-46, (47.65% identity in 298 aa overlap); Q9FUM7 HOMOCYSTEINE S-METHYLTRANSFERASE-4 from Zea mays (Maize) (342 aa),FASTA scores: opt: 324, E(): 6.8e-13, (44.45% identity in 306 aa overlap); Q9LUI7|HMT3 CYSTEINE METHYLTRANSFERASE from Arabidopsis thaliana (Mouse-ear cress) (347 aa),FASTA scores: opt: 312, E(): 3.8e-12, (41.85% identity in 313 aa overlap); etc. Identical to AAK46833|MT2533 HOMOCYSTEINE S-METHYLTRANSFERASE from Mycobacterium tuberculosis strain CDC1551 (302 aa). Q7TYJ3 No intermediary metabolism and respiration Rv2458 NC_002945.3 Mycobrowser_v2 CDS 2729017 2730543 . + 0 Mb2486 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Mb2486, -, len: 508 aa. Equivalent to Rv2459, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 508 aa overlap). Probable conserved integral membrane transport protein, member of major facilitator superfamily (MFS) possibly involved in drug transport, highly similar to many efflux proteins e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 788, E(): 1.3e-38, (34.45% identity in 412 aa overlap); Q9I428|PA1316 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (513 aa), FASTA scores: opt: 782, E(): 3.1e-38,(32.75% identity in 519 aa overlap); P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa), FASTA scores: opt: 752,E(): 1.8e-36, (31.7% identity in 511 aa overlap); etc. Also highly similar to AAK46687|MT2395 DRUG TRANSPORTER from Mycobacterium tuberculosis strain CDC1551 (537 aa),FASTA scores: opt: 1396, E(): 5.6e-74, (44.45% identity in 504 aa overlap); and P71879|Rv2333c|MTCY3G12.01 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (537 aa), FASTA scores: opt: 1385, E(): 2.5e-73, (44.25% identity in 504 aa overlap). Q7TYJ2 No cell wall and cell processes Rv2459 NC_002945.3 Mycobrowser_v2 CDS 2730694 2731338 . - 0 Mb2487c clpP2 PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Mb2487c, clpP2, len: 214 aa. Equivalent to Rv2460c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable clpP2,ATP-dependent clp protease proteolytic subunit 2 (EC 3.4.21.92), equivalent to Q9CBY4|CLP2_MYCLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT from Mycobacterium leprae (214 aa). Also highly similar to others e.g. Q9ZH58|CLPP2 from Streptomyces coelicolor (236 aa), FASTA scores: opt: 918, E(): 2.1e-50, (66.35% identity in 214 aa overlap); O67357|CLPP_AQUAE|AQ_1339 from Aquifex aeolicus (201 aa),FASTA scores: opt: 680, E(): 1.4e-35, (52.0% identity in 194 aa overlap); P43867|CLPP_HAEIN from Haemophilus influenzae (193 aa), FASTA scores: opt: 662, E(): 1.8e-34,(53.35% identity in 193 aa overlap); etc. Contains PS00381 Endopeptidase Clp serine active site. Also similar to upstream ORF Rv2461c|MTV008.17c|clpP1 (200 aa), FASTA score: (48.3% identity in 172 aa overlap). BELONGS TO PEPTIDASE FAMILY S14, ALSO KNOWN AS CLPP FAMILY. X2BL63,P63784 No NC_002945.3 Mycobrowser_v2 CDS 2737149 2739734 . + 0 Mb2494 pepN PROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE) Mb2494, pepN, len: 861 aa. Equivalent to Rv2467,len: 861 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 861 aa overlap). Probable pepN,aminopeptidase N (EC 3.4.11.2), equivalent to Q9CBX9|ML1486 PROBABLE AMINOPEPTIDASE from Mycobacterium leprae (862 aa), FASTA scores: opt: 4751,E(): 0, (83.3% identity in 862 aa overlap). Also highly similar to others e.g. Q11010|AMPN_STRLI|PEPN from Streptomyces lividans (857 aa), FASTA scores: opt: 2839, E(): 1.8e-170, (53.25% identity in 864 aa overlap); Q9L1Z2|PEPN from Streptomyces coelicolor (857 aa), FASTA scores: opt: 2834, E(): 3.8e-170, (53.1% identity in 864 aa overlap); P37896|AMPN_LACDL|PEPN from Lactobacillus delbrueckii (subsp. lactis) (842 aa), FASTA scores: opt: 719, E(): 2.4e-37, (31.65% identity in 439 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M1 (ZINC METALLOPROTEASE), ALSO KNOWN AS THE PEPN SUBFAMILY. Note that previously known as pepD. Q7TYI7 No intermediary metabolism and respiration Rv2467 NC_002945.3 Mycobrowser_v2 CDS 2732054 2733454 . - 0 Mb2489c tig PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG Mb2489c, tig, len: 466 aa. Equivalent to Rv2462c,len: 466 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 466 aa overlap). Probable tig, trigger factor (TF), a chaperone protein, equivalent to Q9CBY2|ML1481 POSSIBLE MOLECULAR CHAPERONE from Mycobacterium leprae (469 aa), FASTA scores: opt: 2171,E(): 7.2e-113, (70.1% identity in 468 aa overlap). Also similar to oyher trigger factors from several organisms e.g. Q9F314|SCC80.05c from Streptomyces coelicolor (468 aa), FASTA scores: opt: 1224, E(): 1.7e-60, (41.8% identity in 469 aa overlap); Q9K8F3|TIG_BACHD from Bacillus halodurans (431 aa), FASTA scores: opt: 675, E(): 3.6e-30, (28.5% identity in 421 aa overlap); P22257|TIG_ECOLI from Escherichia coli (432 aa), FASTA scores: opt: 493, E(): 4.2e-20, (23.35% identity in 433 aa overlap); etc. BELONGS TO THE FKBP-TYPE PPIASE FAMILY, TIG SUBFAMILY. X2BKV3,Q7TYJ1 No NC_002945.3 Mycobrowser_v2 CDS 2733818 2735002 . + 0 Mb2490 lipP PROBABLE ESTERASE/LIPASE LIPP Mb2490, lipP, len: 394 aa. Equivalent to Rv2463,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 394 aa overlap). Probable lipP,esterase (EC 3.1.-.-), lipase similar to others eg O87861|ESTA ESTERASE A from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 964, E(): 1.9e-53, (44.35% identity in 399 aa overlap); Q9I4S7|PA1047 PROBABLE ESTERASE from Pseudomonas aeruginosa (392 aa), FASTA scores: opt: 863, E(): 4.6e-47, (40.05% identity in 377 aa overlap); Q53403|ESTC ESTERASE III from Pseudomonas fluorescens (382 aa), FASTA scores: opt: 753, E(): 3.9e-40, (36.3% identity in 380 aa overlap); etc. Q7TYJ0 No intermediary metabolism and respiration Rv2463 NC_002945.3 Mycobrowser_v2 CDS 2735022 2735828 . - 0 Mb2491c POSSIBLE DNA GLYCOSYLASE Mb2491c, -, len: 268 aa. Equivalent to Rv2464c,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Possible DNA glycosylase (EC 3.2.2.-), showing some similarity to several other DNA glycosylases e.g. Q9F308|SCC80.11c PUTATIVE DNA REPAIR HYDROLASE (FRAGMENT) from Streptomyces coelicolor (306 aa), FASTA scores: opt: 894, E(): 6.1e-51,(51.05% identity in 282 aa overlap); O50606|MUTM|FPG_THETH FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (EC 3.2.2.23) from Thermus aquaticus (267 aa), FASTA scores: opt: 342, E(): 4.6e-15, (32.4% identity in 250 aa overlap); Q9RCW5|SCM10.34c PUTATIVE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Streptomyces coelicolor (287 aa), FASTA scores: opt: 321, E(): 1.1e-13, (29.35% identity in 259 aa overlap); etc. Identical to AAK46839|MT2539 FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium tuberculosis strain CDC1551. Also similar to other M. tuberculosis DNA glycosylases e.g. MTCY71.37 (32.9% identity in 277 aa overlap). BELONGS TO THE FPG FAMILY. X2BKL9,P64159 No information pathways Rv2464c NC_002945.3 Mycobrowser_v2 CDS 2735834 2736322 . - 0 Mb2492c rpib ribose-5-phosphate isomerase Mb2492c, -, len: 162 aa. Equivalent to Rv2465c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Probable isomerase (EC 5.-.-.-), equivalent to AAK46840|MT2540 PUTATIVE CARBOHYDRATE-PHOSPHATE ISOMERASE from Mycobacterium tuberculosis strain CDC1551 (159 aa). Equivalent to Q9CBY1|ML1484 POSSIBLE PHOSPHOPENTOSE ISOMERASE from M. leprae (162 aa), FASTA scores: opt: 992, E(): 7.1e-59,(89.5% identity in 162 aa overlap). Also highly similar or similar to several diverse isomerases e.g. Q9L206|SC8E4.02c PUTATIVE ISOMERASE from Streptomyces coelicolor (159 aa), FASTA scores: opt: 661, E(): 6.1e-37,(61.45% identity in 153 aa overlap); P47636|Y396_MYCGE|MG396 HYPOTHETICAL LACA/RPIB FAMILY PROTEIN from Mycoplasma genitalium (152 aa), FASTA scores: opt: 357, E(): 8.2e-17, (42% identity in 150 aa overlap); P53527|Y396_MYCPN|MPN595|MP247 HYPOTHETICAL LACA/RPIB FAMILY PROTEIN from Mycoplasma pneumoniae (152 aa), FASTA scores: opt: 340, E(): 1.1e-15, (38.6% identity in 145 aa overlap); P26592|LACB_STAAU galactose-6-phosphate isomerase from Staphylococcus aureus (171 aa), FASTA scores: opt: 296, E(): 1e-12, (35.4% identity in 158 aa overlap) and P37351|RPIB_ECOLI ribose 5-phosphate isomerase b from Escherichia coli (149 aa), FASTA scores: opt: 262, E(): 1.6e-10, (32.2% identity in 146 aa overlap); etc. COULD BELONG TO THE LACA/RPIB FAMILY. X2BL66,Q7TYI9 No intermediary metabolism and respiration Rv2465c NC_002945.3 Mycobrowser_v2 CDS 2736424 2737047 . - 0 Mb2493c conserved protein Mb2493c, -, len: 207 aa. Equivalent to Rv2466c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, equivalent to Q9CBY0|ML1485 HYPOTHETICAL PROTEIN from Mycobacterium leprae (207 aa),FASTA scores: opt: 1154, E(): 1.1e-67, (80.6% identity in 206 aa overlap). Also highly similar to Q9L201|SC8E4A.04c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (216 aa), FASTA scores: opt: 789, E(): 4.6e-44, (57.9% identity in 213 aa overlap). Also similar to AAK46628|MT2344 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (230 aa), FASTA scores: opt: 324, E(): 6.1e-14, (30.4% identity in 194 aa overlap). Contains PS00195 Glutaredoxin active site. Q7TYI8 No conserved hypotheticals Rv2466c NC_002945.3 Mycobrowser_v2 CDS 2796600 2796737 . + 0 Mb2541 CONSERVED HYPOTHETICAL PROTEIN Mb2541, -, len: 45 aa. Equivalent to Rv2512A, len: 45 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 45 aa overlap). Conserved hypothetical protein, equivalent to N-terminus of Rv1046c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 293, E(): 2.1e-18, (100.0% identity in 42 aa overlap). Q7TYE9 No Rv2512A NC_002945.3 Mycobrowser_v2 CDS 2740530 2741198 . - 0 Mb2496c CONSERVED HYPOTHETICAL PROTEIN Mb2496c, -, len: 222 aa. Equivalent to Rv2469c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 222 aa overlap). Conserved hypothetical protein, highly similar to other HYPOTHETICAL PROTEINS e.g. Q9X7B4|MLCB1610.15|ML1254 from Mycobacterium leprae (215 aa), FASTA scores: opt: 1183, E(): 3.3e-70, (77.9% identity in 222 aa overlap); Q9L1Y0|SC8E4A.25c from Streptomyces coelicolor (178 aa), FASTA scores: opt: 589,E(): 1.7e-31, (53.4% identity in 161 aa overlap) (N-terminal region is shorter 50 aa approximatively); Q9RRS6|DR2409 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (186 aa), FASTA scores: opt: 440,E(): 9.6e-22, (42.25% identity in 168 aa overlap) (N-terminal region is shorter 30 aa approximatively); etc. Q7TYI5 No conserved hypotheticals Rv2469c NC_002945.3 Mycobrowser_v2 CDS 2741341 2741727 . + 0 Mb2497 glbO globin (oxygen-binding protein) glbo Mb2497, glbO, len: 128 aa. Equivalent to Rv2470,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Possible glbO,globin-like protein, highly similar to Q9CC59|GLBO|ML1253 HEMOGLOBIN-LIKE (OXYGEN CARRIER) from Mycobacterium leprae (128 aa), FASTA scores: opt: 767, E(): 4e-47, (88.1% identity in 126 aa overlap); Q9X7B3|MLCB1610.14c PUTATIVE GLOBIN from Mycobacterium leprae (131 aa); Q9L250|SC6D10.14 PUTATIVE GLOBIN from Streptomyces coelicolor (137 aa), FASTA scores: opt: 466, E(): 5.7e-26,(53.6% identity in 125 aa overlap). Also similar to O31607 YJBI PROTEIN from Bacillus subtilis (132 aa), FASTA scores: opt: 294, E(): 6.6e-14; (39.85% identity in 128 aa overlap). COULD BELONG TO PROTOZOAN/CYANOBACTERIAL GLOBIN FAMILY PROTEIN. X2BKY2,P0A596 No intermediary metabolism and respiration Rv2470 NC_002945.3 Mycobrowser_v2 CDS 2741727 2743367 . + 0 Mb2498 aglA PROBABLE ALPHA-GLUCOSIDASE AGLA (MALTASE) (GLUCOINVERTASE) (GLUCOSIDOSUCRASE) (MALTASE-GLUCOAMYLASE) (LYSOSOMAL ALPHA-GLUCOSIDASE) (ACID MALTASE) Mb2498, aglA, len: 546 aa. Equivalent to Rv2471,len: 546 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 546 aa overlap). Probable aglA, maltase (alpha-glucosidase) (EC 3.2.1.20), highly similar or similar to several e.g. Q60027|AGLA from Thermomonospora curvata (544 aa), FASTA scores: opt: 2071, E(): 4e-116,(57.7% identity in 525 aa overlap); Q9KZE3|AGLAE from Streptomyces coelicolor (534 aa), FASTA scores: opt: 1475,E(): 1.5e-80, (50.1% identity in 537 aa overlap); O86874|AGLA from Streptomyces lividans (534 aa), FASTA scores: opt: 1473, E(): 2e-80, (50.1% identity in 537 aa overlap); etc. SEEMS TO BELONG TO FAMILY 13 OF GLYCOSYL HYDROLASES, ALSO KNOWN AS THE ALPHA-AMYLASE FAMILY. Q7TYI4 No intermediary metabolism and respiration Rv2471 NC_002945.3 Mycobrowser_v2 CDS 2743435 2743728 . + 0 Mb2499 CONSERVED HYPOTHETICAL PROTEIN Mb2499, -, len: 97 aa. Equivalent to Rv2472, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, showing some similarity to O53451|Rv1103c|MTV017.56c from Mycobacterium tuberculosis strain H37Rv (106 aa), FASTA scores: opt: 135, E(): 0.026,(45.85% identity in 72 aa overlap); and AAK45393|MT1135 HYPOTHETICAL 11.4 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (78 aa) FASTA scores: opt: 139, E(): 0.011, (45.35% identity in 75 aa overlap). Q7TYI3 No conserved hypotheticals Rv2472 NC_002945.3 Mycobrowser_v2 CDS 2743731 2744447 . + 0 Mb2500 POSSIBLE ALANINE AND PROLINE RICH MEMBRANE PROTEIN Mb2500, -, len: 238 aa. Equivalent to Rv2473, len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Possible pro-,ala-rich membrane protein, with possible transmembrane domain around aa 81-104. Q7TYI2 No cell wall and cell processes Rv2473 NC_002945.3 Mycobrowser_v2 CDS 2745138 2745554 . - 0 Mb2502c conserved protein Mb2502c, -, len: 138 aa. Equivalent to Rv2475c,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Conserved hypothetical protein, showing similarity with Q9L245|SC6D10.19c HYPOTHETICAL 16.2 KDA PROTEIN from Streptomyces coelicolor (136 aa), FASTA scores: opt: 236,E(): 1.9e-09, (34.1% identity in 126 aa overlap). Also some similarity with AAK44393|Z97050|MTCI28_3 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis cosmid I (151 aa), FASTA scores: opt: 147, E(): 0.00025,(29.2% identity in 120 aa overlap). Q7TYI0 No conserved hypotheticals Rv2475c NC_002945.3 Mycobrowser_v2 CDS 2836059 2836316 . + 0 Mb2577 vapb19 possible antitoxin vapb19 Mb2577, -, len: 85 aa. Equivalent to Rv2547, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein. Some similarity to P71666|YD98_MYCTU|Rv1398c|MT1442|MTCY21B4.15c HYPOTHETICAL 9.4 KDA PROTEIN from Mycobacterium tuberculosis (85 aa),FASTA scores: opt: 108, E(): 0.33, (37.1% identity in 62 aa overlap); CAC45864|SMC01933 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (71 aa), FASTA scores: opt: 105, E(): 0.46, (28.4% identity in 74 aa overlap); Q97W38|SSO10342 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (58 aa), FASTA scores: opt: 94, E(): 2.3, (46.95% identity in 49 aa overlap). Q7TYB8 No virulence, detoxification, adaptation Rv2547 NC_002945.3 Mycobrowser_v2 CDS 2745551 2750422 . - 0 Mb2503c gdh PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE) Mb2503c, gdh, len: 1623 aa. Equivalent to Rv2476c,len: 1624 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1624 aa overlap). Probable gdh,glutamate dehydrogenase (EC 1.4.1.2). Highly similar to Q9X7B2|MLCB1610.10|ML1249 HYPOTHETICAL 177.9 KDA PROTEIN from Mycobacterium leprae (1622 aa), FASTA scores: opt: 8630,E(): 0, (81.45% identity in 1634 aa overlap). But highly similar to Q9F0J1|GDH NAD-GLUTAMATE DEHYDROGENASE from Streptomyces clavuligerus (1651 aa), FASTA scores: opt: 3833, E(): 0, (45.8% identity in 1600 aa overlap); (see first citation). Also similar with others e.g. AAG53963|PA3068|GDHB HYPOTHETICAL (NAD(+)-DEPENDENT GLUTAMATE DEHYDROGENASE from Pseudomonas aeruginosa (1620 aa), FASTA scores: opt: 2214, E(): 1e-124, (40.1% identity in 1561 aa overlap) (see second citation); and Q9Y8G5|GDHB NAD-SPECIFIC GLUTAMATE DEHYDROGENASE from Agaricus bisporus (1029 aa), FASTA scores: opt: 194, E(): 0.00099,(22.7% identity in 647 aa overlap) (see third citation); etc. Contains possible Helix-turn-helix motif at aa 1568 to 1589 (score 1098, +2.93 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa). Q7TYH9 No NC_002945.3 Mycobrowser_v2 CDS 2750526 2752202 . - 0 Mb2504c PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER Mb2504c, -, len: 558 aa. Equivalent to Rv2477c,len: 558 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 558 aa overlap). Probable ATP binding protein ABC-transporter (see citation below), probably involved in macrolide transport, equivalent to Q9X7B1|MLCB1610.09|ML1248 PUTATIVE ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium leprae (556 aa) FASTA scores: opt: 3448, E(): 3.8e-176, (92.3% identity in 557 aa overlap). Also highly similar to many ATP binding proteins e.g. Q9L244|SC6D10.20c PUTATIVE ABC TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (547 aa),FASTA scores: opt: 2937, E(): 5.6e-149, (79.5% identity in 551 aa overlap); AAK24119|CC2148 ABC transporter ATP-binding protein from Caulobacter crescentus (555 aa),FASTA scores: opt: 2175, E(): 1.9e-108, (59.4% identity in 557 aa overlap); Q9HVJ1 PROBABLE ATP-BINDING COMPONENT OF ABC TRANSPORTER from Pseudomonas aeruginosa (554 aa),FASTA scores: opt: 2054, E(): 5.1e-102, (56.9% identity in 559 aa overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop), 2 x PS00211 ABC transporters family signature, and probable coiled-coil from aa 273 to 311. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TYH8 No cell wall and cell processes Rv2477c NC_002945.3 Mycobrowser_v2 CDS 2752283 2752768 . - 0 Mb2505c CONSERVED HYPOTHETICAL PROTEIN Mb2505c, -, len: 161 aa. Equivalent to Rv2478c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Conserved hypothetical protein, with weak similarity with many single-strand binding proteins e.g. Q9X8U3|SCH24.29 PUTATIVE SINGLE-STRAND BINDING PROTEIN from Streptomyces coelicolor (199 aa), FASTA scores: opt: 246, E(): 4.5e-08,(31.5% identity in 162 aa overlap); P46390|SSB_MYCLE|ML2684|MLCB1913.20c SINGLE-STRAND BINDING PROTEIN (SSB) (HELIX-DESTABILIZING PROTEIN) from Mycobacterium leprae (168 aa), FASTA scores: opt: 239,E(): 1e-07, (30.8% identity in 146 aa overlap); P18310|SSBF_ECOLI SINGLE-STRAND BINDING PROTEIN from Escherichia coli (178 aa), FASTA scores: opt: 116, E(): 2.9, (25.7% identity in 140 aa overlap); etc. Also similarity with Rv0054|P71711|MTCY21D4.17|SSB_MYCTU PROBABLE SINGLE-STRAND BINDING PROTEIN from M. tuberculosis (164 aa), FASTA scores: opt: 234, E(): 2e-07,(31.75% identity in 148 aa overlap). N-terminus shorter 8 aa from AAK46855|MT2553 SINGLE-STRAND DNA BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551. Q7TYH7 No conserved hypotheticals Rv2478c NC_002945.3 Mycobrowser_v2 CDS 2775555 2776736 . - 0 Mb2523c bkdc probable branched-chain keto acid dehydrogenase e2 component bkdc Mb2523c, pdhC, len: 393 aa. Equivalent to Rv2495c,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 393 aa overlap). Probable pdhC,dihydrolipoamide S-acetyltransferase, e2 component (EC 2.3.1.12), similar to others e.g. Q9XA49|SCGD3.30c from Streptomyces coelicolor (491 aa) FASTA scores: opt: 615,E(): 1.2e-28, (36.45% identity in 491 aa overlap; several gaps); P19262|ODO2_YEAST|KGD2|YDR148C|YD8358.05c from Saccharomyces cerevisiae (Baker's yeast) (463 aa) FASTA scores: opt: 533, E(): 7.1e-24, (28.55% identity in 396 aa overlap); Q9HN75|DSA|VNG2219G from Halobacterium sp. strain NRC-1 (478 aa), FASTA scores: opt: 521, E(): E(): 3.7e-23, (30.25% identity in 486 aa overlap; in part); etc. BELONGS TO THE 2-OXOACID DEHYDROGENASE FAMILY. Q7TYG2 No NC_002945.3 Mycobrowser_v2 CDS 2753716 2756085 . - 0 Mb2507c plsB2 PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE PLSB2 (GPAT) Mb2507c, plsB2, len: 789 aa. Equivalent to Rv2482c,len: 789 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 789 aa overlap). Probable plsB2,glycerol-3-phosphate acyltransferase (EC 2.3.1.15), highly similar to Q9X7B0|PLSB_MYCLE PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE from Mycobacterium leprae (775 aa), FASTA scores: opt: 4210, E(): 0, (80.7% identity in 783 aa overlap). Also similar to others e.g. P00482|PLSB_ECOLI from Escherichia coli (806 aa), FASTA scores: opt: 521,E(): 3e-24, (24.35 identity in 612 aa overlap); Q9CLN7|PLSB_PASMU from Pasteurella multocida (809 aa),FASTA scores: opt: 529, E(): 9.7e-25, (27.05% identity in 540 aa overlap); Q9KVP8|PLSB_VIBCH from Vibrio cholerae (811 aa), FASTA scores: opt: 510, E(): 1.4e-23, (26.0% identity in 639 aa overlap); etc. Also highly similar to Q10775|PLSB1|Rv1551|MTCY48.14c from Mycobacterium tuberculosis (621 aa), FASTA scores: opt: 1013, E(): 1.5e-54, (34.65% identity in 586 aa overlap). BELONGS TO THE GPAT/DAPAT FAMILY. X2BKY7,Q7TYH5 No NC_002945.3 Mycobrowser_v2 CDS 2756082 2757824 . - 0 Mb2508c plsC possible transmembrane phospholipid biosynthesis bifunctional enzyme plsc: putative l-3-phosphoserine phosphatase (o-phosphoserine phosphohydrolase) (psp) (pspase) + 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-agp acyltransferase) (1-agpat) (lysophosphatidic acid acyltransferase) (lpaat) Mb2508c, plsC, len: 580 aa. Equivalent to Rv2483c,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 580 aa overlap). Possible plsC, a transmembrane phospholipid biosynthesis bifunctionnal enzyme, including L-3-phosphoserine phosphatase (EC 3.1.3.3) and 1-acyl-Sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51), equivalent to Q9X7A9|PLSC|ML1245 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (579 aa), FASTA scores: opt: 2835,E(): 9.2e-153, (77.15% identity in 573 aa overlap). C-terminal end is similar to many 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASES (LYSOPHOSPHATIDIC ACIDACYLTRANSFERASES) e.g. Q9SDQ2 from Limnanthes floccosa (281 aa), FASTA scores: opt: 378, E(): 3.1e-14, (30.0% identity in 230 aa overlap) and Q42868|PLSC_LIMAL from Limnanthes alba (White meadowfoam) (281 aa), FASTA scores: opt: 374, E(): 5.2e-14, (30.55% identity in 221 aa overlap); and the N-terminal end is similar to many SERB FAMILY PROTEINS e.g. AAK44749|MT0526 from Mycobacterium tuberculosis strain CDC1551 (308 aa),FASTA scores: opt: 356, E(): 5.8e-13, (32.5% identity in 298 aa overlap) and Q49823|ML2424 from Mycobacterium leprae (300 aa), FASTA scores: opt: 346, E(): 2.1e-12,(32.0% identity in 278 aa overlap). So belongs to the 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE FAMILY and may belong to the SERB FAMILY. Q7TYH4 No NC_002945.3 Mycobrowser_v2 CDS 2757821 2759296 . - 0 Mb2509c possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb2509c, -, len: 491 aa. Equivalent to Rv2484c,len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 491 aa overlap). Conserved hypothetical protein, highly similar or similar to many Mycobacterial hypothetical proteins e.g. Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 2459, E(): 3e-138, (75.15% identity in 483 aa overlap); O53304|YU87_MYCTU|Rv3087|MTV013.08 from Mycobacterium tuberculosis (472 aa), FASTA scores: opt: 527, E(): 8.1e-24, (29.1% identity in 485 aa overlap); O53305|YU88_MYCTU|Rv3088|MT3173|MTV013.09 from Mycobacterium tuberculosis (474 aa), FASTA scores: opt: 370, E(): 1.6e-14, (26.05% identity in 422 aa overlap); etc. Q7TYH3 No lipid metabolism Rv2484c NC_002945.3 Mycobrowser_v2 CDS 2759525 2760790 . - 0 Mb2510c lipQ PROBABLE CARBOXYLESTERASE LIPQ Mb2510c, lipQ, len: 421 aa. Equivalent to Rv2485c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 421 aa overlap). Probable lipQ,carboxylesterase protein (lipase) (EC 3.1.-.-). Similar (greater at the C-terminal end) to AAK46626|MT2342 PUTATIVE CARBOXYLESTERASE from Mycobacterium tuberculosis strain CDC1551 (431 aa), FASTA scores: opt: 1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap); and Q50681|Rv2284|MTCY339.26c HYPOTHETICAL PROTEIN from M. tuberculosis strain H37Rv (431 aa), FASTA scores: opt: 1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap). Also similar in part to other putative lipases/esterases e.g. AAK44451|MT0230 from Mycobacterium tuberculosis strain CDC1551 (403 aa), FASTA scores: opt: 763, E(): 4.6e-38, (37.95% identity in 390 aa overlap); Q9RY19|DR0133 from Deinococcus radiodurans (296 aa), FASTA scores: opt: 392, E(): 4e-16, (33.7% identity in 276 aa overlap); Q9Z545|SC9B2.14 from Streptomyces coelicolor (502 aa) FASTA scores: opt: 279, E(): 3.2e-09, (31.15% identity in 292 aa overlap); etc. Q7TYH2 No NC_002945.3 Mycobrowser_v2 tRNA 2760978 2761051 . + 0 argW argW tRNA-Arg argW, len: 74 nt. Equivalent to argW, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Arg; anticodon tct. No NC_002945.3 Mycobrowser_v2 CDS 2762102 2762926 . - 0 Mb2512c PE_PGRS42d PE-PGRS FAMILY PROTEIN [THIRD PART] Mb2512c, PE_PGRS42d, len: 274 aa. Similar to 3' end of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 274 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts,PE_PGRS42a and PE_PGRS42b and PE_PGRS42d. No NC_002945.3 Mycobrowser_v2 CDS 2762605 2763777 . - 0 Mb2513c PE_PGRS42b PE-PGRS FAMILY PROTEIN [SECOND PART] Mb2513c, PE_PGRS42b, len: 284 aa. Similar to middle section of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 284 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts,the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d. No NC_002945.3 Mycobrowser_v2 CDS 2763566 2764186 . - 0 Mb2514c PE_PGRS42a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb2514c, PE_PGRS42a, len: 206 aa. Similar to 5' end of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 136 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from M. tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts,PE_PGRS42a and PE_PGRS42b and PE_PGRS42d. Q7TYH1 No NC_002945.3 Mycobrowser_v2 CDS 2764268 2767681 . - 0 Mb2515c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (LUXR-FAMILY) Mb2515c, -, len: 1137 aa. Equivalent to Rv2488c,len: 1137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1137 aa overlap). Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190,(52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory proteins luxR-family from other organisms e.g. Q9CBP3|ML1753 from Mycobacterium leprae (1106 aa), FASTA scores: opt: 2823, E(): 1.5e-156, (50.35% identity in 1116 aa overlap); Q9KYF4|SCD72A.02 from Streptomyces coelicolor (1114 aa), FASTA scores: opt: 915,E(): 1.7e-45, (30.7% identity in 1143 aa overlap); etc. Some similarity with Q9KXP6|SC9C5.28 HYPOTHETICAL 81.8 KDA PROTEIN from Streptomyces coelicolor (750 aa), FASTA scores: opt: 1085, E(): 1.6e-55, (35.45% identity in 722 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, probable coiled-coil from aa 585 to 616 and probable helix-turn-helix motif at aa 1086 to 1107 (score 1206, +3.29 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TYH0 No regulatory proteins Rv2488c NC_002945.3 Mycobrowser_v2 CDS 2767647 2767946 . - 0 Mb2516c HYPOTHETICAL ALANINE RICH PROTEIN Mb2516c, -, len: 99 aa. Equivalent to Rv2489c, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Hypothetical unknown ala-rich protein. Q7TYG9 No conserved hypotheticals Rv2489c NC_002945.3 Mycobrowser_v2 CDS 2796958 2797380 . + 0 Mb2542 HYPOTHETICAL PROTEIN Mb2542, -, len: 140 aa. Equivalent to Rv2513, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 140 aa overlap). Hypothetical unknown protein. Q7TYE8 No conserved hypotheticals Rv2513 NC_002945.3 Mycobrowser_v2 CDS 2768055 2771507 . - 0 Mb2517c PE_PGRS43b PE-PGRS FAMILY PROTEIN [SECOND PART] Mb2517c, PE_PGRS43b, len: 1150 aa. Similar to 3' end of Rv2490c, len: 1660 aa, from Mycobacterium tuberculosis strain H37Rv, (98.0% identity in 1150 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS-subfamily of Gly-rich proteins, similar to many e.g. AAK47971|MT3612.1 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (1715 aa), FASTA scores: opt: 5161, E(): 1.5e-187, (51.7% identity in 1752 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b. Q7TYG8 No NC_002945.3 Mycobrowser_v2 CDS 2771504 2773033 . - 0 Mb2518c PE_PGRS43a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb2518c, PE_PGRS43a, len: 509 aa. Similar to 5' end of Rv2490c, len: 1660 aa, from Mycobacterium tuberculosis strain H37Rv, (98.0% identity in 444 aa overlap). Member of the Mycobacterium tuberculosis PE family,PGRS-subfamily of Gly-rich proteins, similar to many e.g. AAK47971|MT3612.1 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (1715 aa), FASTA scores: opt: 5161, E(): 1.5e-187, (51.7% identity in 1752 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b. Q7TYG7 No NC_002945.3 Mycobrowser_v2 CDS 2773462 2774085 . + 0 Mb2519 CONSERVED HYPOTHETICAL PROTEIN Mb2519, -, len: 207 aa. Equivalent to Rv2491, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 293,E(): 2.8e-11, (42.85% identity in 126 aa overlap); O66531|AQ_134 from Aquifex aeolicus (151 aa), FASTA scores: opt: 261, E(): 2.6e-09, (37.75% identity in 106 aa overlap); Q9HKU3|TA0501 from Thermoplasma acidophilum (161 aa), FASTA scores: opt: 260, E(): 3.2e-09, (35.9% identity in 117 aa overlap); etc. Q7TYG6 No conserved hypotheticals Rv2491 NC_002945.3 Mycobrowser_v2 CDS 2774075 2774827 . + 0 Mb2520 HYPOTHETICAL PROTEIN Mb2520, -, len: 250 aa. Equivalent to Rv2492, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Hypothetical unknown protein. Q7TYG5 No conserved hypotheticals Rv2492 NC_002945.3 Mycobrowser_v2 CDS 2774880 2775101 . + 0 Mb2521 vapb38 possible antitoxin vapb38 Mb2521, -, len: 73 aa. Equivalent to Rv2493, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical protein, highly similar to AAK46916|MT2606 HYPOTHETICAL 8.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (74 aa), FASTA scores: opt: 234, E(): 4e-09,(56.95% identity in 74 aa overlap); and similar to O53373|Rv3321c|MTV016.21c HYPOTHETICAL 8.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (80 aa),FASTA scores: opt: 126, E(): 0.055, (30.75% identity in 78 aa overlap); and with weak similarity with other Mycobacterial hypothetical proteins e.g. Q9CCR7|ML0525 from Mycobacterium leprae (58 aa), FASTA scores: opt: 115,E(): 0.22, (47.75% identity in 44 aa overlap); etc. Q7TYG4 No virulence, detoxification, adaptation Rv2493 NC_002945.3 Mycobrowser_v2 CDS 2776733 2777779 . - 0 Mb2524c bkdb probable branched-chain keto acid dehydrogenase e1 component, beta subunit bkdb Mb2524c, pdhB, len: 348 aa. Equivalent to Rv2496c,len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 348 aa overlap). Probable pdhB,pyruvate dehydrogenase e1 component, beta subunit (EC 1.2.4.1), similar to others e.g. Q9Y8I6||PDHB from Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA scores: opt: 1050, E(): 6.4e-60, (49.7% identity in 324 aa overlap); Q9KG98|BH0214 from Bacillus halodurans (328 aa),FASTA scores: opt: 987, E(): 6.9e-56, (45.7% identity in 324 aa overlap); Q9HN76|PDHB|VNG2218G from Halobacterium sp. strain NRC-1 (297 aa), FASTA scores: opt: 968, E(): 1.1e-54, (51.2% identity in 297 aa overlap); P21874|ODPB_BACST|PDHB PYRUVATE DEHYDROGENASE E1 COMPONENT from Bacillus stearothermophilus (324 aa), FASTA scores: opt: 951, E(): 1.4e-53, (47.6% identity in 321 aa overlap); etc. Also similar to Q9XA61|SCGD3.17c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1, BETA SUBUNIT (2-oxoisovalerate dehydrogenase) (EC 1.2.4.4) from Streptomyces coelicolor, (326 aa), FASTA scores: opt: 1178, E(): 4.1e-68, (55.0% identity in 322 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT from Streptomyces coelicolor (334 aa), FASTA scores: opt: 1173, E(): 8.8e-68, (55.6% identity in 320 aa overlap); Q53593|BKDB E1-BETA BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE from Streptomyces avermitilis (334 aa), FASTA scores: opt: 1132, E(): 3.7e-65, (55.0% identity in 320 aa overlap); etc. Q7TYG1 No NC_002945.3 Mycobrowser_v2 CDS 2777790 2778893 . - 0 Mb2525c bkda probable branched-chain keto acid dehydrogenase e1 component, alpha subunit bkda Mb2525c, pdhA, len: 367 aa. Equivalent to Rv2497c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 367 aa overlap). Probable pdhA,pyruvate dehydrogenase e1 component, alpha subunit (EC 1.2.4.1), similar to many e.g. Q9Y8I5|PDHA from Halobacterium volcanii (Haloferax volcanii) (368 aa) FASTA scores: opt: 961, E(): 1.3e-52, (45.6% identity in 351 aa overlap); BAB40585 from Bacillus sp. UTB2301 (356 aa) FASTA scores: opt: 947, E(): 9.1e-52, (43.1% identity in 355 aa overlap); Q9KG99|BH0213 from Bacillus halodurans (367 aa), FASTA scores: opt: 896, E(): 1.4e-48, (42.65% identity in 340 aa overlap); etc. Also similar to several PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASES E1,BETA SUBUNIT (EC 1.2.4.4), alternate name : 2-oxoisovalerate dehydrogenase, e.g. Q53592|BKDA from Streptomyces avermitilis (381 aa), FASTA scores: opt: 980,E(): 8.5e-54, (45.65% identity in 370 aa overlap); etc. Q7TYG0 No NC_002945.3 Mycobrowser_v2 CDS 2779152 2779973 . - 0 Mb2526c citE PROBABLE CITRATE (PRO-3S)-LYASE (BETA SUBUNIT) CITE (CITRASE) (CITRATASE) (CITRITASE) (CITRIDESMOLASE) (CITRASE ALDOLASE) Mb2526c, citE, len: 273 aa. Equivalent to Rv2498c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Probable citE,citrate lyase, beta subunit (EC 4.1.3.6), similar to others e.g. Q9S3L3|CITE from Corynebacterium glutamicum (Brevibacterium flavum) (217 aa), FASTA scores: opt: 565,E(): 1.5e-28, (41.85% identity in 215 aa overlap); Q9HRM8|CITE|VNG0627G from Halobacterium sp. strain NRC-1 (303 aa), FASTA scores: opt: 535, E(): 1.5e-26, (41.65% identity in 276 aa overlap); Q9S2U9|SC4G6.02 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 426,E(): 1e-19, (37.6% identity in 274 aa overlap); P77770|CILB_ECOLI from Escherichia coli (307 aa), FASTA scores: opt: 265, E(): 1.5e-10, (32.8% identity in 265 aa overlap); etc. Also similar to Rv3075c|MTCY22D7.06 from Mycobacterium tuberculosis, FASTA score: (35.2% identity in 264 aa overlap). Q7TYF9 No NC_002945.3 Mycobrowser_v2 CDS 2779970 2780527 . - 0 Mb2527c POSSIBLE OXIDASE REGULATORY-RELATED PROTEIN Mb2527c, -, len: 185 aa. Equivalent to Rv2499c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Possible oxidase regulatory-related protein, similar to many maoC MONOAMINE OXIDASE REGULATORY PROTEIN e.g. Q9RUZ1|DR1239 MAOC-RELATED PROTEIN from Deinococcus radiodurans (160 aa), FASTA scores: opt: 519, E(): 7.6e-28, (58.1% identity in 148 aa overlap); BAB48392|MLR0905 Probable monoamine oxidase regulatory protein from Rhizobium loti (Mesorhizobium loti) (150 aa), FASTA scores: opt: 480, E(): 2.9e-25,(49.0% identity in 149 aa overlap); Q9HN18|MAOC1|VNG2290G MONOAMINE OXIDASE REGULATORY-LIKE from Halobacterium sp. strain NRC-1 (208 aa), FASTA scores: opt: 419, E(): 4.6e-21, (45.6% identity in 158 aa overlap); P77455|MAOC_ECOLI|PAAZ|B1387 MaoC protein (Phenylacetic acid degradation protein paaZ) from Escherichia coli strain K12 (681 aa), FASTA scores: opt: 252, E(): 1.9e-09,(36.0% identity in 172 aa overlap); etc. But also similar to other proteins with different putative functions e.g. Q9HRM9|MAOC2|VNG0626G MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Halobacterium sp strain NRC-1 (157 aa), FASTA scores: opt: 380, E(): 1.5e-18, (45.75% identity in 153 aa overlap); Q9KIF1 FKBR2 from Streptomyces hygroscopicus var. ascomyceticus (175 aa), FASTA scores: opt: 355, E(): 7.6e-17, (42.0% identity in 150 aa overlap); CAC36828|Q99Q03|SAPE Spore associated protein from Streptomyces coelicolor (174 aa), FASTA scores: opt: 318,E(): 2.2e-14, (41.45% identity in 152 aa overlap); etc. Q7TYF8 No intermediary metabolism and respiration Rv2499c NC_002945.3 Mycobrowser_v2 CDS 2790053 2791390 . - 0 Mb2536c PROBABLE CONSERVED INTEGRAL MEMBRANE LEUCINE AND ALANINE RICH PROTEIN Mb2536c, -, len: 445 aa. Equivalent to Rv2508c,len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Probable conserved integral membrane leu-, ala-rich protein, equivalent to Q9CCU4|ML0430 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (454 aa) (alias O07710|MLCL383.37 longer 10 aa),FASTA scores: opt: 2205, E(): 2.5e-124, (75.75% identity in 441 aa overlap). Also similar to hypothetical or membrane proteins e.g. BAB50841|MLL4103 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (458 aa),FASTA scores: opt: 396, E(): 2.4e-16, (27.75% identity in 447 aa overlap); Q9RKX9|SC6D7.19c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (486 aa),FASTA scores: opt: 323, E(): 5.7e-12, (28.95% identity in 428 aa overlap); P42306|YXIO_BACSU PROBABLE INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (428 aa), FASTA scores: opt: 220, E(): 7.2e-06, (20.35% identity in 413 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31.04c (548 aa),FASTA scores: opt: 184, E(): 0.0012, (24.7% identity in 466 aa overlap). Q7TYF2 No cell wall and cell processes Rv2508c NC_002945.3 Mycobrowser_v2 CDS 2780524 2781708 . - 0 Mb2528c fadE19 POSSIBLE ACYL-COA DEHYDROGENASE FADE19 (MMGC) Mb2528c, fadE19, len: 394 aa. Equivalent to Rv2500c, len: 394 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 394 aa overlap). Possible fadE19 (alternate gene name: mmgC), acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9XCG6|ACDH from Streptomyces coelicolor (386 aa), FASTA scores: opt: 1714, E(): 1.1e-98, (69.45% identity in 383 aa overlap); Q9XCG5|ACDH from Streptomyces avermitilis (386 aa), FASTA scores: opt: 1713, E(): 1.3e-98, (70.0% identity in 383 aa overlap); Q9L7W5|FENK from Bacillus subtilis (370 aa), FASTA scores: opt: 1094, E(): 2.3e-60,(48.4% identity in 372 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TYF7 No lipid metabolism Rv2500c NC_002945.3 Mycobrowser_v2 CDS 2781713 2783677 . - 0 Mb2529c accA1 PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) ACCA1: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP) Mb2529c, accA1, len: 654 aa. Equivalent to Rv2501c,len: 654 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 654 aa overlap). Probable accA1 (alternate gene name: bccA), acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)],similar to others eg Q9L076|FABG from Streptomyces coelicolor (646 aa), FASTA scores: opt: 2071, E(): 1e-113,(57.8% identity in 659 aa overlap); AAK24139|Q9A6C6|CC2168 from Caulobacter crescentus (654 aa), FASTA scores: opt: 1754, E(): 3.7e-95, (47.2% identity in 661 aa overlap); etc. Contains PS00188 Biotin-requiring enzymes attachment site, PS00866 Carbamoyl-phosphate synthase subdomain signature 1, and PS00867 Carbamoyl-phosphate synthase subdomain signature 2. X2BLJ9,P0A509 No NC_002945.3 Mycobrowser_v2 CDS 2783682 2785271 . - 0 Mb2530c accD1 PROBABLE ACETYL-/PROPIONYL-COA CARBOXYLASE (BETA SUBUNIT) ACCD1 Mb2530c, accD1, len: 529 aa. Equivalent to Rv2502c,len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 529 aa overlap). Probable accD1,acetyl-/propionyl-CoA carboxylase (beta subunit) (EC 6.4.1.-), similar, but with N-terminus shorter, to Q9L077|ACCD1 from Streptomyces coelicolor (538 aa), FASTA scores: opt: 2747, E(): 1.9e-159, (77.9% identity in 516 aa overlap). Also similar to others e.g. AAK24141 CC2170 from Caulobacter crescentus (530 aa), FASTA scores: opt: 2413, E(): 3.8e-139, (69.4% identity in 529 aa overlap); BAB54131|MLL7731 from Rhizobium loti (537 aa), FASTA scores: opt: 2399, E(): 2.7e-138, (67.4% identity in 527 aa overlap); etc. COULD BELONG TO THE ACCD/PCCB FAMILY. Q7TYF6 No NC_002945.3 Mycobrowser_v2 CDS 2797674 2798135 . - 0 Mb2543c CONSERVED HYPOTHETICAL PROTEIN Mb2543c, -, len: 153 aa. Equivalent to Rv2514c,len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Conserved hypothetical protein, showing some similarity to Q9PG05|XF0497 HYPOTHETICAL PROTEIN from Xylella fastidiosa (155 aa), FASTA scores: opt: 215, E(): 1.4e-07, (30.6% identity in 160 aa overlap). Q7TYE7 No conserved hypotheticals Rv2514c NC_002945.3 Mycobrowser_v2 CDS 2791475 2792281 . + 0 Mb2537 probable short-chain type dehydrogenase/reductase Mb2537, -, len: 268 aa. Equivalent to Rv2509, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Probable ala-rich oxidoreductase, short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to O07709|MLCL383.36c|ML0429 DEHYDROGENASE (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (268 aa), FASTA scores: opt: 1509, E(): 2.6e-84,(88.75% identity in 267 aa overlap). Also highly similar to others e.g. O86553|SC1F2.16c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 492, E(): 9.5e-23, (38.15% identity in 262 aa overlap); Q9I5R3|PA0658 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (266 aa), FASTA scores: opt: 472,E(): 1.5e-21, (37.8% identity in 246 aa overlap); AAK22120|CC0133 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus (266 aa), FASTA scores: opt: 428, E(): 6.9e-19,(35.8% identity in 243 aa overlap); etc. Also highly similar or similar to oxidoreductases from Mycobacterium tuberculosis e.g. Q10782|Rv1544|MTCY48.21 PUTATIVE KETOACYL REDUCTASE (EC 1.3.1.-) (267 aa), FASTA scores: opt: 656, E(): 1.1e-32, (43.05% identity in 267 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TYF1 No intermediary metabolism and respiration Rv2509 NC_002945.3 Mycobrowser_v2 CDS 2785268 2785924 . - 0 Mb2531c scoB PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE (BETA SUBUNIT) SCOB (3-OXO-ACID:COA TRANSFERASE) (OXCT B) (SUCCINYL CoA:3-OXOACID CoA-TRANSFERASE) Mb2531c, scoB, len: 218 aa. Equivalent to Rv2503c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Probable scoB, 3-oxo acid:CoA transferase, beta subunit (succinyl-CoA:3-ketoacid-CoA transferase) (EC 2.8.3.5). Highly similar to others e.g. Q9XAM8|SC4C6.12c from Streptomyces coelicolor (217 aa), FASTA scores: opt: 1048,E(): 2.6e-60, (73.9% identity in 207 aa overlap); Q9XD82|PCAJ from Streptomyces sp. 2065 (214 aa), FASTA scores: opt: 1031, E(): 3.2e-59, (70.8% identity in 209 aa overlap); AAK53493|LPSJ from Xanthomonas campestris (pv. campestris) (212 aa), FASTA scores: opt: 886, E(): 6.6e-50, (62.5% identity in 208 aa overlap); P42316|SCOB_BACSU from Bacillus subtilis (216 aa), FASTA scores: opt: 820, E(): 1.2e-45, (58.2% identity in 201 aa overlap); etc. BELONGS TO THE 3-OXOACID COA-TRANSFERASE SUBUNIT B FAMILY. X2BL86,P63651 No NC_002945.3 Mycobrowser_v2 CDS 2785921 2786667 . - 0 Mb2532c scoA PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE (ALPHA SUBUNIT) SCOA (3-OXO ACID:CoA TRANSFERASE) (OXCT A) (SUCCINYL-COA:3-OXOACID-COENZYME A TRANSFERASE) Mb2532c, scoA, len: 248 aa. Equivalent to Rv2504c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Probable scoA,succinyl-CoA:3-ketoacid-Coenzyme A transferase, alpha subunit (3-oxo acid:CoA transferase) (EC 2.8.3.6). Highly similar to others e.g. Q9XAM7|SC4C6.13c from Streptomyces coelicolor (260 aa), FASTA scores: opt: 1130, E(): 2.2e-64, (69.9% identity in 249 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA scores: opt: 1121, E(): 8.1e-64, (69.5% identity in 249 aa overlap); etc. BELONGS TO THE 3-OXOACID COA-TRANSFERASE SUBUNIT A FAMILY. X2BKZ9,P63649 No NC_002945.3 Mycobrowser_v2 CDS 2786750 2788393 . - 0 Mb2533c fadD35 PROBABLE FATTY-ACID-COA LIGASE FADD35 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb2533c, fadD35, len: 547 aa. Equivalent to Rv2505c, len: 547 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 547 aa overlap). Probable fadD35, fatty-acid-CoA synthetase (EC 6.2.1.-),highly similar to many e.g. Q9Z5A6|SC2G5.17 from Streptomyces coelicolor (541 aa), FASTA scores: opt: 2202,E(): 8e-131, (61.55% identity in 528 aa overlap); Q9F9U4|FADD from Pseudomonas stutzeri (Pseudomonas perfectomarina), FASTA scores: opt: 1551, E(): 7.3e-90,(55.55% identity in 551 aa overlap); Q987S7|MLR6932 from Rhizobium loti (Mesorhizobium loti) (590 aa), FASTA scores: opt: 1453, E(): 1.1e-83, (50.7% identity in 564 aa overlap); etc. Q7TYF5 No lipid metabolism Rv2505c NC_002945.3 Mycobrowser_v2 CDS 2788509 2789156 . + 0 Mb2534 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb2534, -, len: 215 aa. Equivalent to Rv2506, len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Probable transcriptional regulator, tetR family, similar to many others e.g. Q9L078|SCC105.06c PUTATIVE TETR-FAMILY REGULATORY PROTEIN from Streptomyces coelicolor (208 aa),FASTA scores: opt: 333, E(): 1.5e-14, (48.75% identity in 197 aa overlap); Q9X7X6|SC6A5.30c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (404 aa), FASTA scores: opt: 267, E(): 4.8e-10, (30.45% identity in 207 aa overlap) (similarity only with C-terminus for this one); Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa), FASTA scores: opt: 239, E(): 1.8e-08, (29.9% identity in 184 aa overlap); etc. Also similar to transcriptional regulatory proteins from Mycobacterium tuberculosis e.g. O05858|Rv3208|MTCY07D11.18c (228 aa), FASTA scores: opt: 218, E(): 4.4e-07, (30.35% identity in 191 aa overlap); C-terminus of P95251|Rv1963c|MTV051.01c|MTCY09F9.01 (406 aa), FASTA scores: opt: 238, E(): 3.6e-08, (28.25% identity in 177 aa overlap); P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: 215, E(): 6.2e-07, (38.25% identity in 148 aa overlap); etc. Equivalent to AAK46885 from Mycobacterium tuberculosis strain CDC1551 (231 aa) but shorter 16 aa. Contains probable helix-turn-helix motif at aa 46-67, (Score 1660, +4.84 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TYF4 No regulatory proteins Rv2506 NC_002945.3 Mycobrowser_v2 CDS 2789235 2790056 . + 0 Mb2535 POSSIBLE CONSERVED PROLINE RICH MEMBRANE PROTEIN Mb2535, -, len: 273 aa. Equivalent to Rv2507, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Possible conserved pro-rich membrane protein (N-terminal half is Proline-rich), highly similar to Q9CCU3|ML0431 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (259 aa) (alias O07711|MLCL383.38c but longer 2 aa), FASTA scores: opt: 968, E(): 1.4e-31, (60.35% identity in 275 aa overlap). Contains potential membrane spanning region. Q7TYF3 No cell wall and cell processes Rv2507 NC_002945.3 Mycobrowser_v2 CDS 2792285 2793886 . - 0 Mb2538c conserved protein Mb2538c, -, len: 533 aa. Equivalent to Rv2510c,len: 533 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 533 aa overlap). Hypothetical unknown protein, highly similar, but longer approximatively 20 aa,to others e.g. Q9ABY0|CC0090 HYPOTHETICAL PROTEIN from Caulobacter crescentus (516 aa), FASTA scores: opt: 1282,E(): 8.4e-63, (45.1% identity in 490 aa overlap); Q9A130|SPY0500 HYPOTHETICAL PROTEIN from Streptococcus pyogenes (500 aa), FASTA scores: opt: 1281, E(): 9.3e-63,(43.8% identity in 491 aa overlap); Q985L5|MLR7622 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (515 aa), FASTA scores: opt: 1259, E(): 1.5e-61,(44.1% identity in 510 aa overlap); P39342|YJGR_ECOLI|B4263 HYPOTHETICAL 54.3 KDA PROTEIN from Escherichia coli strain K12 (500 aa), FASTA scores: opt: 1257, E(): 1.9e-61, (42.7% identity in 501 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TYF0 No conserved hypotheticals Rv2510c NC_002945.3 Mycobrowser_v2 CDS 2793954 2794601 . + 0 Mb2539 orn oligoribonuclease orn Mb2539, orn, len: 215 aa. Equivalent to Rv2511,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Probable orn,oligoribonuclease (EC 3.1.-.-), equivalent to O07708|ORN_MYCLE|ORN|ML0427|MLCL383.34c OLIGORIBONUCLEASE from Mycobacterium leprae (215 aa), FASTA scores: opt: 1170, E(): 3.5e-65, (84.5% identity in 213 aa overlap). Also highly similar to many e.g. P57667|ORN_STRGR|ORNA from Streptomyces griseus (201 aa), FASTA scores: opt: 807, E(): 7.7e-43, (59.0% identity in 200 aa overlap); ORN_STRCO|ORNA|2SC13.01 from Streptomyces coelicolor (200 aa), FASTA scores: opt: 799, E(): 2.4e-42, (59.7% identity in 201 aa overlap); P39287|ORN_ECOLI|B4162 from Escherichia coli strain K12 (180 aa), FASTA scores: opt: 519, E(): 3.9e-25, (47.4% identity in 173 aa overlap); etc. BELONGS TO THE OLIGORIBONUCLEASE FAMILY. X2BLK7,P65598 No intermediary metabolism and respiration Rv2511 NC_002945.3 Mycobrowser_v2 tRNA 2794651 2794723 . + 0 hisT hisT tRNA-His hisT, len: 73 nt. Equivalent to hisT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-His, anticodon gtg. No NC_002945.3 Mycobrowser_v2 CDS 2795353 2796600 . - 0 Mb2540c TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081 Mb2540c, -, len: 415 aa. Equivalent to Rv2512c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Transposase for IS1081, identical to P35882|TRA1_MYCBO transposase for insertion sequence element IS1081 from Mycobacterium bovis (415 aa), FASTA scores: opt: 2680, E(): 1.9e-162, (100.0% identity in 415 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV01 2.38c (415 aa), FASTA scores: opt: 2675, E(): 3.9e-162,(99.75% identity in 415 aa overlap). Contains PS00435 Peroxidases proximal heme-ligand signature, PS01007 Transposases, Mutator family, signature. BELONGS TO THE MUTATOR FAMILY OF TRANSPOSASE. X2BGW7,P60231 No insertion seqs and phages Rv2512c NC_002945.3 Mycobrowser_v2 CDS 2798141 2799388 . - 0 Mb2544c CONSERVED HYPOTHETICAL PROTEIN Mb2544c, -, len: 415 aa. Equivalent to Rv2515c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Conserved hypothetical protein, showing some similarity to Q9PG06|XF0496 HYPOTHETICAL PROTEIN from Xylella fastidiosa (391 aa), FASTA scores: opt: 388, E(): 4.4e-18, (27.8% identity in 399 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q7TYE6 No conserved hypotheticals Rv2515c NC_002945.3 Mycobrowser_v2 CDS 2799507 2800310 . - 0 Mb2545c HYPOTHETICAL PROTEIN Mb2545c, -, len: 267 aa. Equivalent to Rv2516c,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(99.625% identity in 267 aa overlap). Hypothetical unknown protein. Contains probable helix-turn-helix motif at aa 98 to 119 (Score 1743, +5.12 SD). C-terminus extended since first submission (+ 18 aa). Q7TYE5 No conserved hypotheticals Rv2516c NC_002945.3 Mycobrowser_v2 CDS 2800906 2802132 . - 0 Mb2547c ldtb probable l,d-transpeptidase ldtb Mb2547c, lppS, len: 408 aa. Equivalent to Rv2518c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Probable lppS,conserved lipoprotein, highly similar to O07707|MLCL383.3 HYPOTHETICAL 43.6 KDA PROTEIN from Mycobacterium leprae (407 aa), FASTA scores: opt: 2300, E(): 1.2e-130, (82.5% identity in 406 aa overlap); Q9CCU5|LPPS|ML0426 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (404 aa), FASTA scores: opt: 2279, E(): 2.3e-129, (82.4% identity in 403 aa overlap); and Q9CB49|ML2446 POSSIBLE LIPOPROTEIN from Mycobacterium leprae (441 aa), FASTA scores: opt: 736,E(): 8.4e-37, (35.6% identity in 399 aa overlap). Also similar to other proteins from several organisms e.g. Q9X811|SC6G10.26c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (424 aa), FASTA scores: opt: 867,E(): 1.1e-44, (32.25% identity in 403 aa overlap); Q9L1E8|SC3D11.14 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 737, E(): 7e-37,(32.95% identity in 413 aa overlap); Q9KYV1|SCE22.11 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (407 aa), FASTA scores: opt: 721, E(): 6.2e-36, (33.5% identity in 400 aa overlap). And similar to several hypothetical mycobacterial proteins e.g. Q11149|Y483_MYCTU|Rv0483|MT0501|MTCY20G9.09 (451 aa),FASTA scores: opt: 763, E(): 2.1e-38, (34.85% identity in 402 aa overlap). Has very long signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TYE3 No NC_002945.3 Mycobrowser_v2 tRNA 2802291 2802363 . + 0 lysU lysU tRNA-Lys lysU, len: 73 nt. Equivalent to lysU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Lys, anticodon ctt. No NC_002945.3 Mycobrowser_v2 CDS 2802582 2804060 . + 0 Mb2548 PE26 pe family protein pe26 Mb2548, PE26, len: 492 aa. Equivalent to Rv2519,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Member of the M. tuberculosis PE family, highly similar to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543 aa),FASTA scores: opt: 848, E(): 3e-30, (39.55% identity in 445 aa overlap). Q7TYE2 No PE/PPE Rv2519 NC_002945.3 Mycobrowser_v2 CDS 2804185 2804412 . - 0 Mb2549c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb2549c, -, len: 75 aa. Equivalent to Rv2520c, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Possible conserved membrane protein, equivalent to O07706|MLCL383.32 HYPOTHETICAL 10.0 KDA PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 290, E(): 4.1e-14, (58.65% identity in 75 aa overlap); and Q9CCU6|ML0425 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (75 aa), FASTA scores: opt: 286, E(): 6.6e-14, (57.35% identity in 75 aa overlap). Q7TYE1 No cell wall and cell processes Rv2520c NC_002945.3 Mycobrowser_v2 CDS 2937449 2937670 . - 0 Mb2678c HYPOTHETICAL PROTEIN Mb2678c, -, len: 73 aa. Equivalent to Rv2660c, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). (questionable orf). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 10982 bp deletion leads to deletion of genes between Mb2677c and Mb2678c compared to Mycobacterium tuberculosis strain H37Rv. Q7TY63 No conserved hypotheticals Rv2660c NC_002945.3 Mycobrowser_v2 CDS 2804481 2804954 . + 0 Mb2550 bcp PROBABLE BACTERIOFERRITIN COMIGRATORY PROTEIN BCP Mb2550, bcp, len: 157 aa. Equivalent to Rv2521,len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 157 aa overlap). Probable bcp,bacterioferritin comigratory protein, equivalent to O07705|BCP|ML0424 from Mycobacterium leprae (161 aa),FASTA scores: opt: 829, E(): 6.8e-46, (79.6% identity in 157 aa overlap). Also highly similar to Q9KZQ2|SCE6.38 HYPOTHETICAL 16.8 KDA PROTEIN Streptomyces coelicolor (155 aa), FASTA scores: opt: 727, E(): 2e-39, (69.5% identity in 154 aa overlap); P23480|AAG57590|BCP_ECOLI|B2480|BAB36765|Z3739|ECS3342 BACTERIOFERRITIN COMIGRATORY PROTEIN from Escherichia coli strain K12 (156 aa), FASTA scores: opt: 513, E(): 8.3e-26,(48.3% identity in 149 aa overlap); Q9RW23|DR0846 BACTERIOFERRITIN COMIGRATORY PROTEIN from Deinococcus radiodurans (175 aa), FASTA scores: opt: 465, E(): 1e-22,(46.5% identity in 157 aa overlap); P44411|BCP_HAEIN|HI0254 BACTERIOFERRITIN COMIGRATORY PROTEIN from Haemophilus influenzae (155 aa), FASTA scores: opt: 453, E(): 5.3e-22, (47.5% identity in 139 aa overlap); etc. Also similar to Mycobacterium tuberculosis Rv1608c|MTV046.06|bcpB and Rv2238c|MTCY427.19c|hpE. Q7TYE0 No virulence, detoxification, adaptation Rv2521 NC_002945.3 Mycobrowser_v2 CDS 2804926 2806338 . - 0 Mb2551c CONSERVED HYPOTHETICAL PROTEIN Mb2551c, -, len: 470 aa. Equivalent to Rv2522c,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 470 aa overlap). Conserved hypothetical protein, equivalent, but longer 20 aa, to Q9X7E4|ML1193|MLCB458.08 from HYPOTHETICAL 46.6 KDA PROTEIN Mycobacterium leprae (442 aa), FASTA scores: opt: 2521, E(): 4.1e-142, (86.35% identity in 440 aa overlap). Also similar to various proteins e.g. Q9K425|SCG22.20 PUTATIVE PEPTIDASE from Streptomyces coelicolor (451 aa),FASTA scores: opt: 1097, E(): 1.1e-57, (42.5% identity in 451 aa overlap); Q9FCK3|2SC3B6.09 PUTATIVE PEPTIDASE from Streptomyces coelicolor (470 aa), FASTA scores: opt: 669,E(): 2.8e-32, (34.2% identity in 462 aa overlap); Q98AF9|MLL6018 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (486 aa), FASTA scores: opt: 622,E(): 1.7e-29, (33.95% identity in 442 aa overlap); Q9RSU7|DR2025 ARGE/DAPE/ACY1 FAMILY PROTEIN from Deinococcus radiodurans (459 aa), FASTA scores: opt: 616,E(): 3.7e-29, (34.15% identity in 442 aa overlap); etc (include some similarity to hypothetical proteins from C. elegans and yeast). Alternative start possible at 6687 but then no RBS obvious. Q7TYD9 No conserved hypotheticals Rv2522c NC_002945.3 Mycobrowser_v2 CDS 2836313 2836690 . + 0 Mb2578 vapc19 possible toxin vapc19 Mb2578, -, len: 125 aa. Equivalent to Rv2548, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Conserved hypothetical protein. Some similarity to various proteins e.g. P71665|Rv1397c|MTCY21B4.14c HYPOTHETICAL 15.0 KDA PROTEIN from Mycobacterium tuberculosis (133 aa), FASTA scores: opt: 265, E(): 7.1e-12, (42.3% identity in 123 aa overlap); Q97WY5|SSO1975 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (125 aa), FASTA scores: opt: 131,E(): 0.018, (30.0% identity in 110 aa overlap); O52285|YLE HYPOTHETICAL 14.9 KDA PROTEIN from Agrobacterium radiobacter (133 aa), FASTA scores: opt: 128, E(): 0.03,(32.8% identity in 125 aa overlap); etc. Q7TYB7 No virulence, detoxification, adaptation Rv2548 NC_002945.3 Mycobrowser_v2 CDS 2806335 2806727 . - 0 Mb2552c acpS HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIER PROTEIN]PANTETHEINEPHOSPHOTRANSFERASE) Mb2552c, acpS, len: 130 aa. Equivalent to Rv2523c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). acpS, holo-[Acyl Carrier Protein] synthase (EC 2.7.8.7) (see citation below), equivalent to Q9X7E3|ACPS_MYCLE|ML1192|MLCB458.07 HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE from Mycobacterium leprae (130 aa), FASTA scores: opt: 732, E(): 5.5e-42,(87.5% identity in 128 aa overlap). Also similar to others e.g. O86785|ACPS_STRCO|SC6G4.22c from Streptomyces coelicolor (123 aa), FASTA scores: opt: 204, E(): 6.6e-07,(36.7% identity in 139 aa overlap); Q9KPB6|VC2457 from Vibrio cholerae (126 aa), FASTA scores: opt: 163, E(): 0.00036, (32.55% identity in 129 aa overlap); P24224|ACPS_ECOLI|DPJ|B2563 from Escherichia coli strain K12 (125 aa), FASTA scores: opt: 151, E(): 0.0022, (30.55% identity in 131 aa overlap); etc. BELONGS TO THE ACPS FAMILY. X2BL12,P0A4W9 No NC_002945.3 Mycobrowser_v2 CDS 2806920 2816129 . - 0 Mb2553c fas PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) Mb2553c, fas, len: 3069 aa. Equivalent to Rv2524c,len: 3069 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 3069 aa overlap). Probable fas,Fatty Acid Synthase (EC 2.3.1.-), equivalent to Q9X7E2|FAS|ML1191 PUTATIVE TYPE I FATTY ACID SYNTHASE from Mycobacterium leprae (3076 aa), FASTA scores: opt: 17484,E(): 0, (85.8% identity in 3081 aa overlap). Also similar to others e.g. Q04846|FAS|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa),FASTA scores: opt: 3981, E(): 5.5e-203, (49.8% identity in 3099 aa overlap); Q48926|FAS from Mycobacterium bovis (2796 aa), FASTA scores: opt: 2098, E(): 3.9e-103, (59.7% identity in 2862 aa overlap) (see first citation below); P34731|FAS1_CANAL FATTY ACID SYNTHASE SUBUNIT BETA from Candida albicans (Yeast) (2037 aa), FASTA scores: opt: 955, E(): 1.3e-42, (27.4% identity in 1926 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00606 Beta-ketoacyl synthases active site. Q7TYD8 No NC_002945.3 Mycobrowser_v2 CDS 2816649 2817371 . - 0 Mb2554c conserved hypothetical protein. secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. Mb2554c, -, len: 240 aa. Equivalent to Rv2525c,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Conserved hypothetical protein, equivalent to Q9X7E1|ML1190|MLCB458.05 HYPOTHETICAL 25.3 KDA PROTEIN from Mycobacterium leprae (239 aa), FASTA scores: opt: 1358, E(): 1e-75, (82.15% identity in 241 aa overlap). Q7TYD7 No conserved hypotheticals Rv2525c NC_002945.3 Mycobrowser_v2 CDS 2818112 2818513 . + 0 Mb2556 vapc17 possible toxin vapc17 Mb2556, -, len: 133 aa. Equivalent to Rv2527, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Hypothetical protein,showing some similarity to hypothetical proteins from Mycobacterium tuberculosis e.g. P95007|MTCY159.10c|Rv2546 (137 aa), FASTA scores: opt: 206, E(): 1.4e-07, (38.0% identity in 100 aa overlap); O33299|MTV002.22c|Rv2757c (138 aa), FASTA scores: opt: 201, E(): 3.1e-07, (35.7% identity in 126 aa overlap); and P96411|MTCY08D5.24c|Rv0229c (226 aa), FASTA scores: opt: 153, E(): 0.0011, (32.8% identity in 128 aa overlap). Q7TYD5 No virulence, detoxification, adaptation Rv2527 NC_002945.3 Mycobrowser_v2 CDS 2818548 2819468 . - 0 Mb2557c mrr PROBABLE RESTRICTION SYSTEM PROTEIN MRR Mb2557c, mrr, len: 306 aa. Equivalent to Rv2528c,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 306 aa overlap). Probable mrr,restriction system protein, similar to other mrr proteins e.g. Q9RWS8|DR0587|MRR from Deinococcus radiodurans (306 aa), FASTA scores: opt: 776, E(): 4.2e-40, (40.45% identity in 309 aa overlap); P24202|MRR_ECOLI|B4351 from Escherichia coli strain K12 (304 aa), FASTA scores: opt: 647, E(): 2.9e-32, (35.25% identity in 309 aa overlap); Q9RX07|DR0508 from Deinococcus radiodurans (336 aa), FASTA scores: opt: 456, E(): 1.3e-20, (37.3% identity in 319 aa overlap); etc. Q7TYD4 No NC_002945.3 Mycobrowser_v2 CDS 2819672 2821063 . + 0 Mb2558 HYPOTHETICAL PROTEIN Mb2558, -, len: 463 aa. Equivalent to Rv2529, len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 463 aa overlap). Hypothetical unknown protein. Note that C-terminal part is similar to short region of Q53609|MTS1_STRAL|SALIM MODIFICATION METHYLASE SALI from Streptomyces albus G (587 aa), FASTA scores: opt: 170, E(): 0.016, (59.45% identity in 37 aa overlap). Q7TYD3 No conserved hypotheticals Rv2529 NC_002945.3 Mycobrowser_v2 CDS 2836706 2837080 . - 0 Mb2578A Conserved protein Mb2578A, len: 124 aa. Equivalent to Rv2548A len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Transferred manually from H37Rv. Conserved protein. X2BKT1 No conserved hypotheticals Rv2548A NC_002945.3 Mycobrowser_v2 CDS 2838659 2839441 . - 0 Mb2582c aroE PROBABLE SHIKIMATE 5-DEHYDROGENASE AROE (5-DEHYDROSHIKIMATE REDUCTASE) Mb2582c, aroE, len: 260 aa. Equivalent to Rv2552c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 260 aa overlap). Probable aroE,shikimate 5-dehydrogenase (EC 1.1.1.25), equivalent to Q9CCS7|AROE|ML0515 PUTATIVE SHIKIMATE 5-DEHYDROGENASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1452,E(): 1.8e-77, (81.5% identity in 270 aa overlap). Also highly similar, but longer 101 aa, to Q9KH59|AROE PUTATIVE SHIKIMATE DEHYDROGENASE (FRAGMENT) from Mycobacterium marinum (148 aa), FASTA scores: opt: 729, E(): 1.3e-35,(76.35% identity in 148 overlap); Q9F7W3|AROE from Mycobacterium ulcerans (148 aa), FASTA scores: opt: 718,E(): 5.9e-35, (75.7% identity in 148 aa overlap). And also similar to to others e.g. Q9KXQ2|AROE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 572, E(): 2.8e-26,(43.4% identity in 251 aa overlap); Q98DY3|MLR4492 from Rhizobium loti (Mesorhizobium loti) (280 aa), FASTA scores: opt: 385, E(): 2.2e-15, (34.85% identity in 284 aa overlap); P74591|AROE_SYNY3|SLR1559 from Synechocystis sp. strain PCC 6803 (290 aa), FASTA scores: opt: 347, E(): 3.7e-13, (30.9% identity in 275 aa overlap); P15770|AROE_ECOLI|B3281 from Escherichia coli strain K12 (272 aa), FASTA scores: opt: 230, E(): 7.7e-08, (29.5% identity in 251 aa overlap); etc. BELONGS TO THE SHIKIMATE DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (t-*) leads to a shorter product compared to Mycobacterium tuberculosis strain H37Rv (260 aa versus 269 aa). Q7TYB3 No NC_002945.3 Mycobrowser_v2 CDS 2867674 2868138 . - 0 Mb2606c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb2606c, -, len: 154 aa. Equivalent to Rv2576c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Possible conserved membrane protein, showing similarity with Q9ZFC2 HYPOTHETICAL 15.7 KDA PROTEIN from Mycobacterium sp. FM10 (146 aa), FASTA scores: opt: 235, E(): 4.1e-08, (31.35% identity in 150 aa overlap). X2BL90,P65022 No cell wall and cell processes Rv2576c NC_002945.3 Mycobrowser_v2 CDS 2821064 2821483 . - 0 Mb2559c vapc39 possible toxin vapc39. contains pin domain. Mb2559c, -, len: 139 aa. Equivalent to Rv2530c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, highly similar to two HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis (strains H37Rv and CDC1551): O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 380, E(): 3.6e-19, (48.0% identity in 125 aa overlap); and O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: 286, E(): 9.3e-13, (41.35% identity in 133 aa overlap); and similar to others e.g. O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 158, E(): 0.00048, (39.55% identity in 129 aa overlap). Also some similarity with CAC48798|SMB20412 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (54 aa), FASTA scores: opt: 184, E(): 3.7e-06, (53.85% identity in 52 aa overlap); and CAC48797|SMB20411 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (82 aa), FASTA scores: opt: 170, E(): 4.8e-05, (44.45% identity in 63 aa overlap). Q7TYD2 No virulence, detoxification, adaptation Rv2530c NC_002945.3 Mycobrowser_v2 CDS 2821480 2821704 . - 0 Mb2559Ac vapb39 possible antitoxin vapb39 Mb2559Ac, -, len: 74 aa. Equivalent to Rv2530A,len: 74 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 74 aa overlap). Conserved hypothetical protein, similar to Q9CCR7|ML0525 HYPOTHETICAL PROTEIN from Mycobacterium leprae (58 aa), FASTA scores: opt: 179,E(): 1.8e-06, (63.65% identity in 44 aa overlap). Highly similar to O53218|Rv2493 from Mycobacterium tuberculosis (73 aa), FASTA scores: opt: 240, E(): 5.7e-11, (56.75% identity in 74 aa overlap); and Q92WE1|RB0399|SMB20413 HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti)p lasmid pSymB (megaplasmid 2) (75 aa), FASTA scores: opt: 226, E(): 6.5e-10, (56.00% identity in 75 aa overlap). Q7TYD1 No virulence, detoxification, adaptation Rv2530A NC_002945.3 Mycobrowser_v2 CDS 2821735 2824578 . - 0 Mb2560c PROBABLE AMINO ACID DECARBOXYLASE Mb2560c, -, len: 947 aa. Equivalent to Rv2531c,len: 947 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 947 aa overlap). Probable amino acid decarboxylase (EC 4.1.1.-), equivalent to Q9CCR8|ADI|ML0524 PUTATIVE AMINO ACID DECARBOXYLASE from Mycobacterium leprae (950 aa), FASTA scores: opt: 5426,E(): 0, (86.45% identity in 951 aa overlap). Also similar to other amino acid decarboxylases (but longer in N-terminus) e.g. Q9I2S7|PA1818 PROBABLE ORN/ARG/LYS AMINO ACID DECARBOXYLASE from Pseudomonas aeruginosa (751 aa),FASTA scores: opt: 434, E(): 2.5e-19, (29.15% identity in 738 aa overlap); Q9CML3|SPEF|PM0806 ORNITHINE DECARBOXYLASE from Pasteurella multocida (720 aa), FASTA scores: opt: 402, E(): 2.4e-17, (24.85% identity in 752 aa overlap); P21169|DCOR_ECOLI|SPEC|B2965|BAB37264|ECS3841|AAG58096 ORNITHINE DECARBOXYLASE ISOZYME (CONSTITUTIVE ENZYME) from Escherichia coli strain K12 (711 aa), FASTA scores: opt: 396, E(): 5.6e-17, (28.0% identity in 646 aa overlap); P44317|DCOR_HAEIN|SPEF|HI0591 ORNITHINE DECARBOXYLASE from Haemophilus influenzae (720 aa), FASTA scores: opt: 393,E(): 8.8e-17, (25.05% identity in 743 aa overlap) ; etc. SEEMS TO BELONG TO FAMILY 1 OF ORNITHINE, LYSINE, AND ARGININE DECARBOXYLASES. Note that previously known as adi. Q7TYD0 No intermediary metabolism and respiration Rv2531c NC_002945.3 Mycobrowser_v2 CDS 2824650 2825051 . - 0 Mb2561c HYPOTHETICAL PROTEIN Mb2561c, -, len: 133 aa. Equivalent to Rv2532c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Hypothetical unknown protein, equivalent to AAK46918 from Mycobacterium tuberculosis strain CDC1551 but shorter 157 aa. Q7TYC9 No conserved hypotheticals Rv2532c NC_002945.3 Mycobrowser_v2 CDS 2825051 2825521 . - 0 Mb2562c nusB N UTILIZATION SUBSTANCE PROTEIN NUSB (NUSB PROTEIN) Mb2562c, nusB, len: 156 aa. Equivalent to Rv2533c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 156 aa overlap). nusB, N utilization substance protein (see citation below), equivalent to Q9CCR9|NUSB_MYCLE|ML0523 N UTILIZATION SUBSTANCE PROTEIN B from Mycobacterium leprae (190 aa), FASTA scores: opt: 749, E(): 2.6e-41, (75.7% identity in 148 aa overlap). Also highly similar to others e.g. Q9KXR0|SC9C5.14 from Streptomyces coelicolor (142 aa), FASTA scores: opt: 358,E(): 2.7e-16, (45.0% identity in 140 aa overlap); P54520|NUSB_BACSU from Bacillus subtilis (131 aa), FASTA scores: opt: 315, E(): 1.5e-13, (39.55% identity in 129 aa overlap); O83979|NUSB_TREPA|TP1015 from Treponema pallidum (141 aa), FASTA scores: opt: 268, E(): 1.6e-10, (36.95% identity in 138 aa overlap); etc. BELONGS TO THE NUSB FAMILY. X2BL35,Q7TYC8 No NC_002945.3 Mycobrowser_v2 CDS 2937667 2938056 . - 0 Mb2679c HYPOTHETICAL PROTEIN Mb2679c, -, len: 129 aa. Equivalent to Rv2661c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Hypothetical unknown protein. Q7TY62 No conserved hypotheticals Rv2661c NC_002945.3 Mycobrowser_v2 CDS 2825524 2826087 . - 0 Mb2563c efp PROBABLE ELONGATION FACTOR P EFP Mb2563c, efp, len: 187 aa. Equivalent to Rv2534c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable efp,elongation factor P, equivalent to Q9CCS0|EFP|ML0522 ELONGATION FACTOR P from Mycobacterium leprae (187 aa),FASTA scores: opt: 1158, E(): 2.1e-67, (94.1% identity in 186 aa overlap). Also highly similar to many e.g. Q45288|EFP_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (187 aa), FASTA scores: opt: 843,E(): 3.4e-47, (69.5% identity in 187 aa overlap); Q9KXQ9|EFP from Streptomyces coelicolor (188 aa), FASTA scores: opt: 833, E(): 1.5e-46, (67.0% identity in 188 aa overlap); P49778|EFP_BACSU from Bacillus subtilis (185 aa), FASTA scores: opt: 607, E(): 4.6e-32, (47.8% identity in 182 aa overlap); P33398|EFP_ECOLI|B4147 from Escherichia coli strain K12 (187 aa), FASTA scores: opt: 503, E(): 1.8e-27, (42.3% identity in 182 aa overlap); etc. BELONGS TO THE ELONGATION FACTOR P FAMILY. X2BLM5,P64035 No NC_002945.3 Mycobrowser_v2 CDS 4133531 4133890 . + 0 Mb3774 CONSERVED HYPOTHETICAL PROTEIN Mb3774, -, len: 119 aa. Equivalent to Rv3748, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 119 aa overlap). Hypothetical protein,highly similar to upstream ORF O69714|Rv3747|MTV025.095 CONSERVED HYPOTHETICAL PROTEIN (127 aa), FASTA scores: opt: 496, E(): 2.5e-28, (64.4% identity in 118 aa overlap). Q7TVS5 No conserved hypotheticals Rv3748 NC_002945.3 Mycobrowser_v2 CDS 2826097 2827215 . - 0 Mb2564c pepQ probable cytoplasmic peptidase pepq Mb2564c, pepQ, len: 372 aa. Equivalent to Rv2535c,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 372 aa overlap). Probable pepQ,cytoplasmic peptidase (EC 3.4.-.-), equivalent to Q9CCS1|PEPQ|ML0521 PUTATIVE CYTOPLASMIC PEPTIDASE from Mycobacterium leprae (376 aa), FASTA scores: opt: 1954,E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also similar to other peptidases e.g. P54518|YQHT_BACSU PUTATIVE PEPTIDASE (BELONGS TO PEPTIDASE FAMILY M24B) from Bacillus subtilis (353 aa), FASTA scores: opt: 808, E(): 1.6e-39, (39.65% identity in 368 aa overlap); Q9KXQ8|SC9C5.16c PUTATIVE PEPTIDASE from Streptomyces coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39,(43.15% identity in 380 aa overlap); Q9K950|BH2800 XAA-PRO DIPEPTIDASE from Bacillus halodurans (355 aa), FASTA scores: opt: 801, E(): 4.1e-39, (39.45% identity in 365 aa overlap); etc. Note that second part of protein is similar to second part of MTCY49.29c|Rv2089c|MT2150|MTCY49.29c PROBABLE DIPEPTIDASE (EC 3.4.13.-; BELONGS TO PEPTIDASE FAMILY M24B) from Mycobacterium tuberculosis (375 aa) (33.9% identity in 354 aa overlap) BLAST RESULTS: Score: 142 bits (359), E: 4e-33, Identities: 86/224 (38%),Positives: 119/224 (52%), Gaps: 4/224 (1%). COULD BE BELONG TO PEPTIDASE FAMILY M24B. Q7TYC7 No NC_002945.3 Mycobrowser_v2 CDS 2827249 2827941 . + 0 Mb2565 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2565, -, len: 230 aa. Equivalent to Rv2536, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CCS2|ML0520 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (202 aa), FASTA scores: opt: 812, E(): 2e-41, (63.2% identity in 201 aa overlap). Also similar in part to Q9HMD5|VNG2594c from Halobacterium sp. strain NRC-1 (117 aa), FASTA scores: opt: 33.6, E(): 1.8, (33.6% identity in 116 aa overlap); and perhaps AAK65752|SMA1996 PUTATIVE ABC TRANSPORTER PERMEASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (323 aa), FASTA scores: opt: 117, E(): 6.1, (30.6% identity in 121 aa overlap). Q7TYC6 No cell wall and cell processes Rv2536 NC_002945.3 Mycobrowser_v2 CDS 2834577 2835239 . + 0 Mb2574 lppB PROBABLE CONSERVED LIPOPROTEIN LPPB Mb2574, lppB, len: 220 aa. Equivalent to Rv2544,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable lppB,conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 PUTATIVE LIPOPROTEIN LPPA from Mycobacterium tuberculosis (219 aa),FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TYC1 No cell wall and cell processes Rv2544 NC_002945.3 Mycobrowser_v2 CDS 2827945 2828388 . - 0 Mb2566c aroD 3-dehydroquinate dehydratase arod (aroq) (3-dehydroquinase) (type ii dhqase) Mb2566c, aroD, len: 147 aa. Equivalent to Rv2537c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). aroD (alternate gene name: aroQ), 3-dehydroquinate dehydratase (EC 4.2.1.10) (see citation below), equivalent to Q9CCS3|AROD|ML0519 3-DEHYDROQUINATE DEHYDRATASE from Mycobacterium leprae (145 aa), FASTA scores: opt: 803, E(): 3.4e-46, (85.9% identity in 142 aa overlap). Also highly similar to many e.g. P96750|AROQ_CORPS from Corynebacterium pseudotuberculosis (146 aa), FASTA scores: opt: 559, E(): 4.1e-30, (61.05% identity in 136 aa overlap); Q9K949|BH2801 from Bacillus halodurans (145 aa), FASTA scores: opt: 453, E(): 4e-23, (52.15% identity in 138 aa overlap); P54517|AROQ_BACSU|YQHS from Bacillus subtilis (148 aa), FASTA scores: opt: 419, E(): 7.1e-21, (45.3% identity in 139 aa overlap); etc. Contains PS01029 Dehydroquinase class II signature. BELONGS TO THE TYPE-II 3-DEHYDROQUINASE FAMILY. X2BL19,P0A4Z7 No NC_002945.3 Mycobrowser_v2 CDS 2828385 2829473 . - 0 Mb2567c aroB 3-DEHYDROQUINATE SYNTHASE AROB Mb2567c, aroB, len: 362 aa. Equivalent to Rv2538c,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 362 aa overlap). aroB,3-dehydroquinate synthase (EC 4.2.3.4) (see citation below), equivalent to Q9CCS4|AROB_MYCLE|ML0518 3-DEHYDROQUINATE SYNTHASE from Mycobacterium leprae (361 aa), FASTA scores: opt: 2059, E(): 3.3e-117, (87.25% identity in 361 aa overlap). Also highly similar to many e.g. Q9KXQ6|AROB from Streptomyces coelicolor (363 aa),FASTA scores: opt: 1363, E(): 4e-75, (60.05% identity in 358 aa overlap); Q9X5D2|AROB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (366 aa), FASTA scores: opt: 1154, E(): 1.7e-62, (50.95% identity in 359 aa overlap); P07639|AROB_ECOLI|B3389 from Escherichia coli strain K12 (362 aa), FASTA scores: opt: 771, E(): 2.4e-39,(40.6% identity in 345 aa overlap); etc. BELONGS TO THE DEHYDROQUINATE SYNTHASE FAMILY. X2BL40,P0A4Z5 No NC_002945.3 Mycobrowser_v2 CDS 2829470 2830000 . - 0 Mb2568c aroK shikimate kinase arok (sk) Mb2568c, aroK, len: 176 aa. Equivalent to Rv2539c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Probable aroK,shikimate kinase (EC 2.7.1.71) (see citation below),equivalent to Q9CCS5|AROK|ML0517 PUTATIVE SHIKIMATE KINASE from Mycobacterium leprae (199 aa), FASTA scores: opt: 852, E(): 1.3e-42, (79.65% identity in 167 aa overlap). Also highly similar to many e.g. Q9X5D1|AROK_CORG from Corynebacterium glutamicum (Brevibacterium flavum) (169 aa), FASTA scores: opt: 478, E(): 5.4e-21, (47.0% identity in 168 aa overlap); Q9KXQ5|AROK from Streptomyces coelicolor (171 aa), FASTA scores: opt: 465, E(): 3.1e-20,(49.1% identity in 167 aa overlap); P24167|AROK_ECOLI from Escherichia coli strain K12 (172 aa), FASTA scores: opt: 316, E(): 1.3e-11, (38.4% identity in 164 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A, and PS01128 Shikimate kinase signature. BELONGS TO THE SHIKIMATE KINASE FAMILY. X2BLN0,P0A4Z3 No NC_002945.3 Mycobrowser_v2 CDS 2837180 2837575 . - 0 Mb2579c vapc20 possible toxin vapc20 Mb2579c, -, len:131 aa. Equivalent to Rv2549c, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing some similarity to P73415|SLL1715 from Synechocystis sp. strain PCC 6803 (157 aa), FASTA scores: opt: 167, E(): 4.2e-05, (29.45% identity in 129 aa overlap); Q9HHY6|VNG6166H from Halobacterium sp. plasmid pNRC200 strain NRC-1 (144 aa),FASTA scores: opt: 133, E(): 0.011, (29.6% identity in 125 aa overlap); and Q9HSU3|VNG0072H from Halobacterium sp. strain NRC-1 (144 aa), FASTA scores: opt: 113, E(): 0.29,(25.75% identity in 136 aa overlap). Q7TYB6 No virulence, detoxification, adaptation Rv2549c NC_002945.3 Mycobrowser_v2 CDS 2830004 2831209 . - 0 Mb2569c aroF PROBABLE CHORISMATE SYNTHASE AROF (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE PHOSPHOLYASE) Mb2569c, aroF, len: 401 aa. Equivalent to Rv2540c,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Probable aroF (alternate gene name: aroC), chorismate synthase (EC 4.2.3.5), equivalent to Q9CCS6|AROF|ML0516 PUTATIVE CHORISMATE SYNTHASE from Mycobacterium leprae (407 aa),FASTA scores: opt: 2278, E(): 6.2e-123, (88.05% identity in 401 aa overlap). Also highly similar to many e.g. Q9X5D0|AROC_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (410 aa), FASTA scores: opt: 1811,E(): 3e-96, (70.3% identity in 397 aa overlap); Q9KXQ4|AROC_STRCO|AROF|SC9C5.20c from Streptomyces coelicolor (394 aa), FASTA scores: opt: 1710, E(): 1.7e-90, (67.0% identity in 385 aa overlap); Q9KCB7|AROC_BACHD|AROF|BH1656 from Bacillus halodurans (390 aa), FASTA scores: opt: 1196, E(): 3.9e-61, (48.7% identity in 386 aa overlap); etc. Contains PS00788 Chorismate synthase signature 2. BELONGS TO THE CHORISMATE SYNTHASE FAMILY. COFACTOR: REDUCED FLAVIN. X2BKS6,P63612 No NC_002945.3 Mycobrowser_v2 CDS 2831224 2831631 . + 0 Mb2570 HYPOTHETICAL ALANINE RICH PROTEIN Mb2570, -, len: 135 aa. Equivalent to Rv2541, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Hypothetical unknown ala-rich protein, equivalent to AAK46926|MT2615.1 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 but AAK46926|MT2615.1 longer at C-terminus. Questionable ORF. Some similarity with Rv2077A from Mycobacterium tuberculosis (99 aa). Q7TYC5 No conserved hypotheticals Rv2541 NC_002945.3 Mycobrowser_v2 CDS 2831927 2833138 . + 0 Mb2571 conserved hypothetical protein Mb2571, -, len: 403 aa. Equivalent to Rv2542, len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 265 aa overlap). Conserved hypothetical protein, highly similar to AAK46927|MT2616 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa), FASTA scores: opt: 1776, E(): 2.3e-94,(99.25% identity in 265 aa overlap). And similar to several hypothetical proteins from Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. P71654|Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: opt: 537, E(): 2.6e-23, (40.75% identity in 292 aa overlap); P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 (266 aa),FASTA scores: opt: 357, E(): 2.6e-13, (34.6% identity in 234 aa overlap); Q10685|YK77_MYCTU|Rv2077c|MT2137|MTCY49.16c (323 aa),FASTA scores: opt: 261, E(): 9.5e-08, (32.7% identity in 211 aa overlap); etc. Also similar to Q9RDQ9|SC4A7.03 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FASTA scores: opt: 247, E(): 7.3e-07, (30.35% identity in 303 aa overlap). Q7TYC4 No conserved hypotheticals Rv2542 NC_002945.3 Mycobrowser_v2 CDS 2833265 2833924 . + 0 Mb2572 lppA PROBABLE CONSERVED LIPOPROTEIN LPPA Mb2572, lppA, len: 219 aa. Equivalent to Rv2543,len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Probable lppA,conserved lipoprotein, highly similar to upstream orf P95009|LPPB|Rv2544|MTCY159.12 PUTATIVE LIPOPROTEIN LPPB from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 1240, E(): 1.1e-73, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TYC3 No cell wall and cell processes Rv2543 NC_002945.3 Mycobrowser_v2 CDS 2833921 2834580 . + 0 Mb2573 lprR PROBABLE CONSERVED LIPOPROTEIN LPRR Mb2573, lprR, len: 219 aa. Equivalent to MT2619,len: 219 aa, from Mycobacterium tuberculosis strain CDC1551, (99.55% identity in 219 aa overlap). Also similar to Rv2543 and Rv2544, len: 219 aa and 220 aa, from Mycobacterium tuberculosis strain H37Rv, (88.15% identity in 219 aa overlap and 84.40% identity in 218 aa overlap). See citation below. Rv2543: Probable lppA, conserved lipoprotein, highly similar to upstream ORF P95009|LPPB|Rv2544|MTCY159.12 PUTATIVE LIPOPROTEIN LPPB from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 1240, E(): 1.1e-73, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Rv2544: Probable lppB,conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 PUTATIVE LIPOPROTEIN LPPA from Mycobacterium tuberculosis (219 aa),FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,there is a 656 bp insertion relative to Mycobacterium tuberculosis strain H37Rv. Q7TYC2 No NC_002945.3 Mycobrowser_v2 CDS 2835236 2835514 . + 0 Mb2575 vapb18 possible antitoxin vapb18 Mb2575, -, len: 92 aa. Equivalent to Rv2545, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Conserved hypothetical protein. C-terminus highly similar to O33300|Rv2758c|MTV002.23c PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: 151, E(): 9.8e-05, (66.65% identity in 45 aa overlap); and Q10771|Rv1560|MT1611|MTCY48.05 PROTEIN from Mycobacterium tuberculosis (72 aa), FASTA scores: opt: 84, E(): 8.2,(46.5% identity in 43 aa overlap). Q7TYC0 No virulence, detoxification, adaptation Rv2545 NC_002945.3 Mycobrowser_v2 CDS 2937962 2938234 . + 0 Mb2680 HYPOTHETICAL PROTEIN Mb2680, -, len: 90 aa. Equivalent to Rv2662, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein. Q7TY61 No conserved hypotheticals Rv2662 NC_002945.3 Mycobrowser_v2 CDS 2839464 2840717 . - 0 Mb2583c PROBABLE CONSERVED MEMBRANE PROTEIN Mb2583c, -, len: 417 aa. Equivalent to Rv2553c,len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 417 aa overlap). Probable conserved membrane protein, equivalent to Q9CCS8|ML0514 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (421 aa), FASTA scores: opt: 1955, E(): 1.1e-111, (72.7% identity in 414 aa overlap). Also similar in part to various proteins e.g. Q9L9G6|NOVB NOVB PROTEIN (aminodesoxychorismate lyase) from Streptomyces sphaeroides (284 aa), FASTA scores: opt: 451, E(): 2.9e-2, (37.95% identity in 203 aa overlap); Q9EWY3|2SCG38.36 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (253 aa), FASTA scores: opt: 419,E(): 2.3e-18, (39.2% identity in 171 aa overlap); Q9CHT3|YGCC HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (550 aa), FASTA scores: opt: 379, E(): 1.2e-15, (23.0% identity in 417 aa overlap); O25309|HP0587 AMINODEOXYCHORISMATE LYASE (PABC) from Helicobacter pylori (Campylobacter pylori) (329 aa),FASTA scores: opt: 290, E(): 2e-10, (31.65% identity in 180 aa overlap); etc. Q7TYB2 No cell wall and cell processes Rv2553c NC_002945.3 Mycobrowser_v2 CDS 2840710 2841222 . - 0 Mb2584c conserved protein Mb2584c, -, len: 170 aa. Equivalent to Rv2554c,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 170 aa overlap). Conserved hypothetical protein, equivalent to Q9CCS9|ML0513 HYPOTHETICAL PROTEIN from Mycobacterium leprae (184 aa),FASTA scores: opt: 701, E(): 2e-34, (72.05% identity in 161 aa overlap). Also highly similar to Q9KXQ0|SC9C5.24c HYPOTHETICAL 17.7 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 461, E(): 2.3e-20, (54.65% identity in 150 aa overlap); and similar to other hypothetical proteins e.g. Q9KDE4 from Bacillus halodurans (140 aa), FASTA scores: opt: 291, E(): 1.9e-10, (38.7% identity in 137 aa overlap); P74662|SLL1547 from Synechocystis sp. strain PCC 6803 (152 aa), FASTA scores: opt: 290, (36.55% identity in 145 aa overlap); Q52673|YQGF_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (159 aa), FASTA scores: opt: 246, E(): 8.4e-08, (34.8% identity in 135 aa overlap); etc. X2BLB4,P67488 No conserved hypotheticals Rv2554c NC_002945.3 Mycobrowser_v2 CDS 2841223 2843937 . - 0 Mb2585c alaS PROBABLE ALANYL-TRNA SYNTHETASE ALAS (ALANINE--TRNA LIGASE) (ALANINE TRANSLASE) (ALARS) Mb2585c, alaS, len: 904 aa. Equivalent to Rv2555c,len: 904 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 904 aa overlap). Probable alaS,alanyl-tRNA synthetase (EC 6.1.1.7), equivalent to Q9CCT0|ALAS|ML0512 ALANYL-TRNA SYNTHETASE from Mycobacterium leprae (908 aa), FASTA scores: opt: 5013,E(): 0, (84.65% identity in 907 aa overlap). Also highly similar to many e.g. Q9KXP9|ALAS from Streptomyces coelicolor (890 aa), FASTA scores: opt: 2159, E(): 3.8e-118, (53.45% identity in 907 aa overlap); Q9FFC7 Arabidopsis thaliana (Mouse-ear cress) (954 aa), FASTA scores: opt: 1963, E(): 1.1e-106, (41.1% identity in 925 aa overlap); Q9RS27|DR2300 from Deinococcus radiodurans (890 aa), FASTA scores: opt: 1352, E(): 4.1e-71, (38.05% identity in 915 aa overlap); etc. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. X2BL31,Q7TYB1 No NC_002945.3 Mycobrowser_v2 CDS 2844028 2844417 . - 0 Mb2586c CONSERVED HYPOTHETICAL PROTEIN Mb2586c, -, len: 129 aa. Equivalent to Rv2556c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, highly similar to others e.g. Q9EWY5|2SCG38.34 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (140 aa), FASTA scores: opt: 488,E(): 8.2e-26, (58.8% identity in 131 aa overlap); Q9L9G4|NOVD NOVD PROTEIN from Streptomyces sphaeroides (143 aa), FASTA scores: opt: 474, E(): 7.2e-25, (60.85% identity in 120 aa overlap); Q9X2I5|TM1872 from Thermotoga maritima (132 aa), FASTA scores: opt: 270, E(): 2.7e-11,(39.55% identity in 129 aa overlap); etc. X2BL61 No conserved hypotheticals Rv2556c NC_002945.3 Mycobrowser_v2 CDS 2846023 2847381 . - 0 Mb2589c CONSERVED HYPOTHETICAL ALANINE LEUCINE VALINE RICH PROTEIN Mb2589c, -, len: 452 aa. Equivalent to Rv2559c,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 452 aa overlap). Conserved hypothetical ala-, leu-, val-rich protein, equivalent to Q9CCT1|ML0510 HYPOTHETICAL PROTEIN from Mycobacterium leprae (473 aa),FASTA scores: opt: 2411, E(): 3.9e-121, (83.4% identity in 452 aa overlap); O69490|O69490 HYPOTHETICAL 47.1 KDA PROTEIN from Mycobacterium leprae (447 aa), FASTA scores: opt: 2406, E(): 6.9e-121, (83.95% identity in 448 aa overlap). Also highly similar to Q9KXP4|SC9C5.30c CONSERVED ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (451 aa), FASTA scores: opt: 1742, E(): 1.5e-85, (64.4% identity in 430 aa overlap); Q9RT67|DR1898 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (434 aa), FASTA scores: opt: 1147, E(): 6.6e-54, (46.0% identity in 415 aa overlap); P45262|YCAJ_HAEIN|HI1590 HYPOTHETICAL PROTEIN from Haemophilus influenzae (446 aa), FASTA scores: opt: 1140,E(): 1.6e-53, (42.5% identity in 428 aa overlap); etc. Also similar to Q50629|MTCY227.09|RUVB|Rv2592c|MT2669|MTCY227.09 HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium tuberculosis (344 aa), (30.1% identity in 296 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TYB0 No conserved hypotheticals Rv2559c NC_002945.3 Mycobrowser_v2 CDS 2847527 2848504 . + 0 Mb2590 PROBABLE PROLINE AND GLYCINE RICH TRANSMEMBRANE PROTEIN Mb2590, -, len: 325 aa. Equivalent to Rv2560, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). Probable transmembrane protein, pro-, gly-rich protein. X2BL32,P59983 No cell wall and cell processes Rv2560 NC_002945.3 Mycobrowser_v2 CDS 2848861 2849598 . + 0 Mb2591 CONSERVED HYPOTHETICAL PROTEIN Mb2591, -, len: 245 aa. Similar to Rv2561 and Rv2562, len: 97 aa and 129 aa, from Mycobacterium tuberculosis strain H37Rv, (87.3% identity in 79 aa overlap and 99.2% identity in 129 aa overlap). Conserved hypothetical protein, highly similar in part (and longer 33 aa) to upstream ORF AAK46951|RV2562|MT2638|MTCY9C4.06c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (212 aa), FASTA scores: opt: 205, E(): 2e-06,(76.1% identity in 46 aa overlap). Conserved hypothetical protein, highly similar, but shorter 83 aa, to downstream ORF AAK46951|RV2561|MT2638|MTCY9C4.07c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 aa), FASTA scores: opt: 866, E(): 2.2e-54, (100.0% identity in 129 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis, a single base deletion (g-*) results in a single product which is more similar to Rv2561. Q7TYA9 No NC_002945.3 Mycobrowser_v2 CDS 2849741 2850790 . + 0 Mb2592 PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb2592, -, len: 349 aa. Equivalent to Rv2563, len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Probable glutamine-transport transmembrane protein ABC transporter (see citation below), highly similar to O53617|Rv0072|MTV030.16 PUTATIVE ABC-TRANSPORTER TRANSMEMBRANE SUBUNIT from Mycobacterium tuberculosis (349 aa), FASTA scores: opt: 1772, E(): 1.1e-89, (76.2% identity in 349 aa overlap). Also some similarity with various hypothetical proteins e.g. Q9RYN1|DRA0279 HYPOTHETICAL 37.1 KDA PROTEIN from Deinococcus radiodurans (353 aa), FASTA scores: opt: 347, E(): 6.6e-12, (24.35% identity in 357 aa overlap); BAB58522|SAV2360 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (351 aa), FASTA scores: opt: 262, E(): 2.9e-07, (19.4% identity in 356 aa overlap); Q9AK94|SC10A9.10c PUTATIVE ABC TRANSPORT SYSTEM TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 172, E(): 0.025, (26.85% identity in 387 aa overlap); etc. X2BLQ1,P65008 No cell wall and cell processes Rv2563 NC_002945.3 Mycobrowser_v2 CDS 2850793 2851785 . + 0 Mb2593 glnQ PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER GLNQ Mb2593, glnQ, len: 330 aa. Equivalent to Rv2564,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Probable glnQ,glutamine-transport ATP-binding protein ABC transporter (see citation below), highly similar to many e.g. Q9L0J9|SCD40A.12c PUTATIVE ABC-TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (246 aa), FASTA scores: opt: 598, E(): 2.5e-26, (46.35% identity in 218 aa overlap); O54136|SC2E9.11 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 592, E(): 5.1e-26, (46.55% identity in 219 aa overlap); O29244|AF1018 from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 580,E(): 2.4e-25, (42.4% identity in 210 aa overlap); P75831|YBJZ_ECOLI|B0879 from Escherichia coli strain K12 (648 aa), FASTA scores: opt: 555, E(): 1.3e-23, (39.65% identity in 232 aa overlap); etc. Also highly similar to O53618|Rv0073|MTV030.17 ABC-TRANSPORTER ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (330 aa), FASTA scores: opt: 1782, E(): 4.7e-92, (83.65% identity in 330 aa overlap); etc. Shows some similarity to Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium tuberculosis (612 aa) (32.9 % identity in 234 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BKU1,P63402 No cell wall and cell processes Rv2564 NC_002945.3 Mycobrowser_v2 CDS 2852062 2853813 . + 0 Mb2594 conserved protein Mb2594, -, len: 583 aa. Equivalent to Rv2565, len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 583 aa overlap). Conserved hypothetical protein, similar in part to Q9A6C3|CC2171 HYPOTHETICAL PROTEIN from Caulobacter crescentus (610 aa),FASTA scores: opt: 765, E(): 2.8e-37, (32.15% identity in 575 aa overlap). C-terminus also highly similar to various bacterial proteins e.g. O34731|YLBK_BACSU HYPOTHETICAL 28.3 KDA PROTEIN from Bacillus subtilis (260 aa), FASTA scores: opt: 386, E(): 2.2e-15, (33.05% identity in 245 aa overlap); CAC45997|SMC01003 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (321 aa),FASTA scores: opt: 352, E(): 2.5e-13, (29.65% identity in 280 aa overlap); Q9K9Q8|BH2587 HYPOTHETICAL PROTEIN from Bacillus halodurans (275 aa), FASTA scores: opt: 334, E(): 2.5e-12, (33.7% identity in 175 aa overlap); etc. And shows similarity to C-terminal half of some eukaryotic proteins e.g. Q9R114|NTE NEUROPATHY TARGET ESTERASE HOMOLOG from Mus musculus (Mouse) (1327 aa), FASTA scores: opt: 411, E(): 2.7e-16, (24.45% identity in 626 aa overlap); O60859 NEUROPATHY TARGET ESTERASE from Homo sapiens (Human) (1327 aa), FASTA scores: opt: 410, E(): 3.1e-16, (24.1% identity in 627 aa overlap); Q9U969|SWS|CG2212 SWISS CHEESE PROTEIN from Drosophila melanogaster (Fruit fly) (1425 aa), FASTA scores: opt: 401, E(): 1.1e-15, (27.75% identity in 544 aa overlap); etc. Also shows strong similarity to C-terminal half of O05884|Z95121|Rv3239c|MTY20B11.14c HYPOTHETICAL 110.2 KDA PROTEIN from Mycobacterium tuberculosis (1048 aa), FASTA scores: opt: 648, E(): 3e-30, (36.55% identity in 572 aa overlap); and O69695|Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 643, E(): 6e-30, (34.3% identity in 595 aa overlap). X2BLC0,P0A643 No conserved hypotheticals Rv2565 NC_002945.3 Mycobrowser_v2 CDS 2853824 2855425 . + 0 Mb2595 LONG CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb2595, -, len: 533 aa. Equivalent to 5' end of Rv2566, len: 1140 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 531 aa overlap). Long conserved hypothetical protein, equivalent to O53120|ML2678 OR MLCB1913.12 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1000 aa), FASTA scores: opt: 760,E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and middle part equivalent to Q9ZB40 72.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (644 aa), FASTA scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77,(52.4% identity in 1148 aa overlap); and N-terminus shows similarity with other proteins e.g. Q9HUN8|PA4926 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (311 aa),FASTA scores: opt: 278, E(): 3e-09, (29.95% identity in 284 aa overlap); and upstream ORF Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (314 aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity in 315 aa overlap). Equivalent to AAK46955 from Mycobacterium tuberculosis strain CDC1551 (1156 aa) but shorter 16 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts, Mb2595 and Mb2596. Q7TYA8 No NC_002945.3 Mycobrowser_v2 CDS 2855451 2857244 . + 0 Mb2596 LONG CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb2596, -, len: 597 aa. Equivalent to 3' end of Rv2566, len: 1140 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 597 aa overlap). Long conserved hypothetical protein, equivalent to O53120|ML2678 OR MLCB1913.12 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1000 aa), FASTA scores: opt: 760,E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and middle part equivalent to Q9ZB40 72.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (644 aa), FASTA scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77,(52.4% identity in 1148 aa overlap); and N-terminus shows similarity with other proteins e.g. Q9HUN8|PA4926 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (311 aa),FASTA scores: opt: 278, E(): 3e-09, (29.95% identity in 284 aa overlap); and upstream ORF Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (314 aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity in 315 aa overlap). Equivalent to AAK46955 from Mycobacterium tuberculosis strain CDC1551 (1156 aa) but shorter 16 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts, Mb2595 and Mb2596. Q7TYA7 No NC_002945.3 Mycobrowser_v2 CDS 2857244 2859898 . + 0 Mb2597 CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH PROTEIN Mb2597, -, len: 884 aa. Equivalent to Rv2567, len: 884 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 884 aa overlap). Conserved hypothetical ala-, leu-rich protein, equivalent to O53121|ML2679|MLCB1913.13 HYPOTHETICAL PROTEIN from Mycobacterium leprae (893 aa), FASTA scores: opt: 4326,E(): 0, (75.2% identity in 883 aa overlap); and similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 HYPOTHETICAL 61.8 KDA PROTEIN from Mycobacterium leprae (561 aa), FASTA scores: opt: 758, E(): 1.2e-38, (32.2% identity in 537 aa overlap). Also similar to others e.g. Q9HUN7|PA4927 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (830 aa), FASTA scores: opt: 1247, E(): 2.2e-68, (38.25% identity in 831 aa overlap); Q98HG7|MLL2876 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (803 aa), FASTA scores: opt: 937,E(): 1.9e-49, (32.15% identity in 828 aa overlap); CAC47419|SMC04057 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (802 aa),FASTA scores: opt: 900, E(): 3.4e-47, (30.85% identity in 852 aa overlap); etc. And similar to P71732|YO11_MYCTU|Rv2411c|MT2484|MTCY253.09 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (551 aa), FASTA scores: opt: 781, E(): 4.6e-40, (33.75% identity in 495 aa overlap). X2BLQ4 No conserved hypotheticals Rv2567 NC_002945.3 Mycobrowser_v2 CDS 2859895 2860920 . - 0 Mb2598c CONSERVED HYPOTHETICAL PROTEIN Mb2598c, -, len: 341 aa. Equivalent to Rv2568c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 341 aa overlap). Conserved hypothetical protein, highly similar (but longer 60 aa) to Q98E75|MLR4376 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (308 aa), FASTA scores: opt: 566,E(): 4.1e-29, (40.2% identity in 291 aa overlap). X2BKU3 No conserved hypotheticals Rv2568c NC_002945.3 Mycobrowser_v2 CDS 2860913 2861857 . - 0 Mb2599c CONSERVED HYPOTHETICAL PROTEIN Mb2599c, -, len: 314 aa. Equivalent to Rv2569c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Conserved hypothetical protein, equivalent to Q9CCT2|ML0508 HYPOTHETICAL PROTEIN from Mycobacterium leprae (313 aa),FASTA scores: opt: 1723, E(): 1.9e-95, (84.4% identity in 301 aa overlap); and some similarity with Q49757|YP69_MYCLE|ML0607|MLCL536.03c|B1937_F2_39 HYPOTHETICAL 31.1 KDA PROTEIN from Mycobacterium leprae (279 aa), FASTA scores: opt: 305, E(): 4.5e-11, (33.0% identity in 300 aa overlap). Also similar to to other hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas aeruginosa (311 aa), FASTA scores: opt: 704, E(): 8.7e-35,(39.7% identity in 320 aa overlap); Q98HG8|MLL2875 from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: opt: 521, E(): 6.5e-24, (35.05% identity in 294 aa overlap); Q9A7W9|CC1600 from Caulobacter crescentus (325 aa), FASTA scores: opt: 510, E(): 3.2e-23, (34.4% identity in 2588 aa overlap); etc. Also some similarity with proteins from Mycobacterium tuberculosis e.g. P71734|Rv2409c|MTCY253.11 CONSERVED HYPOTHETICAL PROTEIN (279 aa), FASTA scores: opt: 312, E(): 1.7e-11, (34.45% identity in 296 aa overlap); and Q50732|Rv2566|MTCY9C4.02 LONG CONSERVED HYPOTHETICAL PROTEIN (1140 aa), FASTA scores: opt: 252, E(): 2.2e-07, (28.9% identity in 315 aa overlap) X2BLC2 No conserved hypotheticals Rv2569c NC_002945.3 Mycobrowser_v2 CDS 2861961 2862350 . + 0 Mb2600 CONSERVED HYPOTHETICAL PROTEIN Mb2600, -, len: 129 aa. Equivalent to Rv2570, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to Q98GQ7|MLR3218 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (133 aa), FASTA scores: opt: 174, E(): 9.6e-05,(32.25% identity in 124 aa overlap); Q9A390|CC3314 HYPOTHETICAL PROTEIN from Caulobacter crescentus (129 aa),FASTA scores: opt: 155, E(): 0.0017, (33.35% identity in 108 aa overlap); and Q9A2Y0|CC3426 HYPOTHETICAL PROTEIN from Caulobacter crescentus (120 aa), FASTA scores: opt: 144, E(): 0.0083, (32.95% identity in 91 aa overlap). X2BL39 No conserved hypotheticals Rv2570 NC_002945.3 Mycobrowser_v2 CDS 2862342 2863409 . - 0 Mb2601c PROBABLE TRANSMEMBRANE ALANINE AND VALINE AND LEUCINE RICH PROTEIN Mb2601c, -, len: 355 aa. Equivalent to Rv2571c,len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 355 aa overlap). Probable transmembrane ala-, val-, leu-rich protein, showing some similarity with other membrane proteins e.g. Q99340|YFDA_CORGL HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (359 aa), FASTA scores: opt: 338, E(): 2.5e-13, (29.4% identity in 255 aa overlap); Q9RD86|SCF43.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 208, E(): 2.1e-05, (26.05% identity in 303 aa overlap); Q9RD81|SCF43.07 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (419 aa), FASTA scores: opt: 205, E(): 3.5e-05, (25.15% identity in 362 aa overlap); etc. X2BL82,P65016 No cell wall and cell processes Rv2571c NC_002945.3 Mycobrowser_v2 CDS 2863416 2865251 . - 0 Mb2602c aspS probable aspartyl-trna synthetase asps (aspartate--trna ligase) (asprs) (aspartic acid translase) Mb2602c, aspS, len: 611 aa. Equivalent to Rv2572c,len: 596 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 595 aa overlap). Probable aspS,aspartyl-tRNA synthetase (EC 6.1.1.12), equivalent to P36429|SYD_MYCLE|ML0501|MLCB1259.19 ASPARTYL-TRNA SYNTHETASE from Mycobacterium leprae (589 aa), FASTA scores: opt: 3534, E(): 1.8e-215, (87.85% identity in 592 aa overlap). Also highly similar to many e.g. O67589|SYD_AQUAE|AQ_1677 from Aquifex aeolicus (603 aa),FASTA scores: opt: 1829, E(): 8.2e-108, (47.5% identity in 598 aa overlap); O32038|SYD_BACSU from Bacillus subtilis (592 aa), FASTA scores: opt: 1732, E(): 1.1e-101, (46.25% identity in 597 aa overlap); P21889|SYD_ECOLI|TLS|B1866 from Escherichia coli strain K12 (590 aa), FASTA scores: opt: 1588, E(): 1.3e-92, (47.35% identity in 581 aa overlap); etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (t-*) omitting a stop codon, leads to a longer protein with a different COOH end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (611 aa versus 596 aa). X2BLQ7,Q7TYA6 No NC_002945.3 Mycobrowser_v2 CDS 2865401 2866231 . + 0 Mb2603 CONSERVED HYPOTHETICAL PROTEIN Mb2603, -, len: 275 aa. Equivalent to 2-dehydropantoate 2-reductase from Mycobacterium tuberculosis strain CDC1551 (100% identity with 274 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. Rv2573, len: 246 aa, from Mycobacterium tuberculosis strain H37Rv, Q9ABG6|CC0261 HYPOTHETICAL PROTEIN from Caulobacter crescentus (290 aa),Q99R37|SA2393 HYPOTHETICAL PROTEIN (similar to 2-dehydropantoate 2-reductase) from Staphylococcus aureus subsp. aureus N315 (286 aa), Q9KPQ9|VC2307 2-DEHYDROPANTOATE 2-REDUCTASE from Vibrio cholerae (296 aa). PArt of the Ketopantoate reductase PanE/ApbA superfamily. Mb2603 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BKU7 No NC_002945.3 Mycobrowser_v2 CDS 2866254 2866757 . + 0 Mb2604 conserved protein Mb2604, -, len: 167 aa. Equivalent to Rv2574, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Conserved hypothetical protein, showing similarity with Q9K3N3|SCG20A.07 HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218,E(): 2.8e-08, (30.65% identity in 150 aa overlap). X2BLC4 No conserved hypotheticals Rv2574 NC_002945.3 Mycobrowser_v2 CDS 3029499 3029630 . - 0 Mb2784c CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb2784c, -, len: 43 aa. Equivalent to 5' end of Rv2762c, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 43 aa overlap). Conserved hypothetical protein, similar to C-terminus of hypothetical proteins: Q9A380|CC3324 from Caulobacter crescentus (409 aa), FASTA scores: opt: 181, E(): 9.8e-05,(43.55% identity in 101 aa overlap); Q98KQ4|MLR1373 from Rhizobium loti (Mesorhizobium loti) (399 aa), FASTA scores: opt: 174, E(): 0.00028, (46.35% identity in 82 aa overlap); and Q9HZZ9|PA2844 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 158, E(): 0.0033, (40.0% identity in 80 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2762c into 2 parts, Mb2783c and Mb2784c. Q7TXX9 No NC_002945.3 Mycobrowser_v2 CDS 2866787 2867668 . + 0 Mb2605 POSSIBLE CONSERVED MEMBRANE GLYCINE RICH PROTEIN Mb2605, -, len: 293 aa. Equivalent to Rv2575, len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 293 aa overlap). Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (313 aa), FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. X2BL41,P65020 No cell wall and cell processes Rv2575 NC_002945.3 Mycobrowser_v2 CDS 2868366 2868617 . + 0 Mb2607 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb2607, -, len: 83 aa. Equivalent to 5' end of Rv2577, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 83 aa overlap). Conserved hypothetical protein, showing similarity with various proteins from eukaryotes, in particular phosphatases, e.g. Q9SE01|PAP PURPLE ACID PHOSPHATASE PRECURSOR (EC 3.1.3.2) from Glycine max (Soybean) (464 aa), FASTA scores: opt: 190, E(): 0.00026, (27.3% identity in 388 aa overlap); Q9SVP2|F18A5.90|AT4G13700 HYPOTHETICAL 53.4 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (474 aa), FASTA scores: opt: 280, E(): 6.6e-10,(27.2% identity in 331 aa overlap); Q9FK32 SIMILARITY TO UNKNOWN PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (529 aa), FASTA scores: opt: 249, E(): 6.2e-08,(25.3% identity in 435 aa overlap); Q12546|APHA ACID PHOSPHATASE PRECURSOR from Aspergillus ficuum (614 aa),FASTA scores: opt: 207, E(): 2.9e-05, (22.95% identity in 458 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (g-a) splits Rv2577 into 2 parts,Mb2607 and Mb2608. Q7TYA4 No NC_002945.3 Mycobrowser_v2 CDS 2868651 2869955 . + 0 Mb2608 CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb2608, -, len: 434 aa. Equivalent to 3' end of Rv2577, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 434 aa overlap). Conserved hypothetical protein, showing similarity with various proteins from eukaryotes, in particular phosphatases, e.g. Q9SE01|PAP PURPLE ACID PHOSPHATASE PRECURSOR (EC 3.1.3.2) from Glycine max (Soybean) (464 aa), FASTA scores: opt: 190, E(): 0.00026, (27.3% identity in 388 aa overlap); Q9SVP2|F18A5.90|AT4G13700 HYPOTHETICAL 53.4 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (474 aa), FASTA scores: opt: 280, E(): 6.6e-10,(27.2% identity in 331 aa overlap); Q9FK32 SIMILARITY TO UNKNOWN PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (529 aa), FASTA scores: opt: 249, E(): 6.2e-08,(25.3% identity in 435 aa overlap); Q12546|APHA ACID PHOSPHATASE PRECURSOR from Aspergillus ficuum (614 aa),FASTA scores: opt: 207, E(): 2.9e-05, (22.95% identity in 458 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2577 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits Rv2577 into 2 parts, Mb2607 and Mb2608. Q7TYA3 No NC_002945.3 Mycobrowser_v2 CDS 2869957 2870979 . - 0 Mb2609c CONSERVED HYPOTHETICAL PROTEIN Mb2609c, -, len: 340 aa. Equivalent to Rv2578c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Conserved hypothetical protein, highly similar to hypothetical proteins (conserved or not) e.g. Q9ZBJ3|SC9C7.17c from Streptomyces coelicolor (348 aa), FASTA scores: opt: 998,E(): 1.6e-55, (47.6% identity in 355 aa overlap); Q9I763|PA0069 from Pseudomonas aeruginosa (352 aa), FASTA scores: opt: 560, E(): 6e-28, (36.6% identity in 284 aa overlap); Q986C9|MLL7417 from Rhizobium loti (Mesorhizobium loti) (356 aa), FASTA scores: opt: 550,E(): 2.6e-27, (39.15% identity in 240 aa overlap); etc. X2BLC7,P65024 No conserved hypotheticals Rv2578c NC_002945.3 Mycobrowser_v2 CDS 2871087 2871989 . + 0 Mb2610 dhaA POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE HALIDOHYDROLASE) Mb2610, dhaA, len: 300 aa. Equivalent to Rv2579,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 300 aa overlap). Possible dhaA,haloalkane dehalogenase (EC 3.8.1.5), strictly equivalent to Q9XB14|ISO-RV2579 HALOALKANE DEHALOGENASE (1-chlorohexane halidohydrolase) (EC 3.8.1.5) from Mycobacterium bovis (300 aa), FASTA scores: opt: 2075,E(): 7.1e-125, (99.35% identity in 300 aa overlap); note that only two residues, 120 and 293 are different. Also highly similar to others e.g. Q9ZER0|DHAAF HALOALKANE DEHALOGENASE from Mycobacterium sp strain GP1 (307 aa),FASTA scores: opt: 842, E(): 2.3e-46, (44.95% identity in 298 aa overlap); Q53042|DHAA HALOALKANE DEHALOGENASE from Rhodococcus rhodochrous, and Pseudomonas pavonaceae (293 aa), FASTA scores: opt: 837, E(): 4.5e-46, (44.6% identity in 298 aa overlap); etc. Note that this protein may also be a 1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase (EC 3.8.1.-), because also highly similar to P51698|LINB_PSEPA 1,3,4,6-TETRACHLORO-1,4-CYCLOHEXADIENE HYDROLASE from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (see first citation below) (296 aa), FASTA scores: opt: 1494,E(): 6.8e-88, (69.5% identity in 295 aa overlap). Also shows some similarity with proteins from Mycobacterium tuberculosis e.g. Q50670|YM96_MYCTU|Rv2296|MT2353|MTCY339.14c PUTATIVE HALOALKANE DEHALOGENASE (300 aa), FASTA scores: opt: 302,E(): 5.3e-12, (30.85% identity in 295 aa overlap); and Q50600|YJ33_MYCTU|Rv1833c|MT1881|MTCY1A11.10 HYPOTHETICAL 32.2 KDA PROTEIN (286 aa), FASTA scores: opt: 286, E(): 5.3e-11, (29.85% identity in 288 aa overlap). MAY BE BELONG TO ALPHA/BETA HYDROLASE FOLD FAMILY. Note that previously known as linB. X2BL44,Q9XB14 No intermediary metabolism and respiration Rv2579 NC_002945.3 Mycobrowser_v2 CDS 2872269 2873540 . - 0 Mb2611c hisS probable histidyl-trna synthetase hiss (histidine--trna ligase) (hisrs) (histidine--translase) Mb2611c, hisS, len: 423 aa. Equivalent to Rv2580c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 423 aa overlap). Probable hisS,histidyl-tRNA synthetase (EC 6.1.1.21), equivalent to P46696|SYH_MYCLE|HISS|ML0494|MLCB1259.12|B1177_C3_248 HISTIDYL-TRNA SYNTHETASE from Mycobacterium leprae (427 aa), FASTA scores: opt: 2380, E(): 2.1e-131, (85.85% identity in 417 aa overlap). Also highly similar to many e.g. Q9KXP2|HISS from Streptomyces coelicolor (425 aa),FASTA scores: opt: 1542, E(): 1.4e-82, (56.0% identity in 418 aa overlap); O32422|SYH_STAAU|HISS from Staphylococcus aureus (420 aa), FASTA scores: opt: 1135, E(): 7.4e-59,(44.9% identity in 412 aa overlap); P04804|SYH_ECOLI|HISS|B2514 from Escherichia coli strain K12 (423 aa), FASTA scores: opt: 1099, E(): 9.4e-57,(43.9% identity in 417 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. X2BL97,P67484 No NC_002945.3 Mycobrowser_v2 CDS 2873537 2874211 . - 0 Mb2612c POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II) Mb2612c, -, len: 224 aa. Equivalent to Rv2581c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible glyoxalase II (EC 3.1.2.6), equivalent to Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247 HYPOTHETICAL 23.9 KDA PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1264, E(): 7.8e-73, (82.0% identity in 222 aa overlap). Also highly similar to Q9KXP1|SC9C5.33c POSSIBLE HYDROLASE from Streptomyces coelicolor (235 aa), FASTA scores: opt: 654, E(): 2.9e-34,(46.8% identity in 220 aa overlap); and similar to Q9CI24|YFCI HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (210 aa), FASTA scores: opt: 360, E(): 9.9e-16, (35.0% identity in 217 aa overlap); AAK75726|SP1646 METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN from Streptococcus pneumoniae (209 aa), FASTA scores: opt: 320, E(): 3.3e-13, (35.85% identity in 198 aa overlap); AAK80229|CAC2272 PREDICTED ZN-DEPENDENT HYDROLASE OF METALLO-BETA-LACTAMASE SUPERFAMILY from Clostridium acetobutylicum (199 aa),FASTA scores: opt: 282, E(): 8e-11, (32.7% identity in 217 aa overlap); etc. Equivalent to AAK46971 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 22 aa. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS. X2BLR5,P64262 No virulence, detoxification, adaptation Rv2581c NC_002945.3 Mycobrowser_v2 CDS 2874262 2875188 . + 0 Mb2613 ppiB PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B PPIB (CYCLOPHILIN) (PPIASE) (ROTAMASE) (PEPTIDYLPROLYL ISOMERASE) Mb2613, ppiB, len: 308 aa. Equivalent to Rv2582,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 308 aa overlap). Probable ppiB (alternate gene name: ppi), cyclophilin (peptidyl-prolyl cis-trans isomerase) (EC 5.2.1.8), equivalent to P46697|PPIB_MYCLE|PPI|ML0492|MLCB1259.10c|B1177_F3_97 PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B from Mycobacterium leprae (295 aa), FASTA scores: opt: 1423,E(): 1.3e-66, (72.2% identity in 295 aa overlap). Aldo similar to others e.g. Q9KJG8|PPIB PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces lividans (277 aa),FASTA scores: opt: 485, E(): 3.2e-18, (38.35% identity in 292 aa overlap); Q9KXP0|SC9C5.34 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 483, E(): 4.1e-18, (38.35% identity in 292 aa overlap); Q9RT72|DR1893 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Deinococcus radiodurans (350 aa), FASTA scores: opt: 296, E(): 2.2e-08, (29.0% identity in 276 aa overlap); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY. Q7TYA2 No information pathways Rv2582 NC_002945.3 Mycobrowser_v2 CDS 2875274 2877646 . - 0 Mb2614c relA PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'-PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE) Mb2614c, relA, len: 790 aa. Equivalent to Rv2583c,len: 790 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 790 aa overlap). Probable relA, GTP pyrophosphokinase (EC 2.7.6.5), equivalent to Q49640|RELA_MYCLE|ML0491|MLCB1259.09|B1177_C1_168 PROBABLE GTP PYROPHOSPHOKINASE from Mycobacterium leprae (787 aa),FASTA scores: opt: 4834, E(): 0, (93.4% identity in 790 aa overlap). Also highly similar to others e.g. O87331|RELA_CORGL|RELA|REL from Corynebacterium glutamicum (Brevibacterium flavum) (760 aa), FASTA scores: opt: 3375,E(): 1.6e-196, (67.0% identity in 758 aa overlap); O85709|RELA_STRAT from Streptomyces antibioticus (841 aa),FASTA scores: opt: 3209, E(): 1.9e-186, (63.85% identity in 786 aa overlap); Q9KDH1|RELA|BH1242 from Bacillus halodurans (728 aa), FASTA scores: opt: 2195,E(): 3.8e-125, (45.65% identity in 714 aa overlap); etc. BELONGS TO THE RELA / SPOT FAMILY. X2BLD0,P66015 No NC_002945.3 Mycobrowser_v2 CDS 2877677 2878348 . - 0 Mb2615c apt ADENINE PHOSPHORIBOSYLTRANSFERASE APT (APRT) (AMP DIPHOSPHORYLASE) (AMP PYROPHOSPHORYLASE) (TRANSPHOSPHORIBOSIDASE) Mb2615c, apt, len: 223 aa. Equivalent to Rv2584c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 223 aa overlap). Probable apt, adenine phosphoribosyltransferase (EC 2.4.2.7), similar, but longer in N-terminus, to others e.g. O87330|APT_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (185 aa), FASTA scores: opt: 524, E(): 1.3e-24, (50.95% identity in 159 aa overlap); P52561|APT_STRCO from Streptomyces coelicolor (182 aa), FASTA scores: opt: 503,E(): 2.3e-23, (51.85% identity in 164 aa overlap); P47956|APT_MUSPA|APRT from Mus pahari (Shrew mouse) (180 aa), FASTA scores: opt: 419, E(): 2.5e-18, (44.7% identity in 170 aa overlap); P07672|P09993|P77121|APT_ECOLI|B0469 from Escherichia coli strain K12 (183 aa), FASTA scores: opt: 393, E(): 1.9e-18, (42.6% identity in 162 aa overlap); etc. Contains PS00103 Purine/ pyrimidine phosphoribosyl transferases signature, and PS00144 Asparaginase / glutaminase active site signature 1. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. Nearest initiation codon indicated by homology is TTG at 17426 or GTG at 17465. X2BL45,P59959 No NC_002945.3 Mycobrowser_v2 CDS 2878452 2880125 . - 0 Mb2616c POSSIBLE CONSERVED LIPOPROTEIN Mb2616c, -, len: 557 aa. Equivalent to Rv2585c,len: 557 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 557 aa overlap). Possible conserved lipoprotein precursor, possibly attached to the membrane by a lipid anchor and substrate-binding protein involved in transport, equivalent to Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C2_197 HYPOTHETICAL LIPOPROTEIN PRECURSOR from Mycobacterium leprae (555 aa), FASTA scores: opt: 2812, E(): 9.8e-158,(78.95% identity in 546 aa overlap); and C-terminus highly similar to C-terminus of Q49638|DCIAE|B1177_C1_166 DCIAE PROTEIN from Mycobacterium leprae (344 aa), FASTA scores: opt: 1177, E(): 7.4e-62, (78.6% identity in 229 aa overlap). Also similar in part to various proteins,principally substrate-binding proteins, e.g. O87329|DCIAE DIPEPTIDE-BINDING PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (502 aa), FASTA scores: opt: 614,E(): 1.2e-28, (30.7% identity in 427 aa overlap); Q9AKR0|OPPA|CAC49261 PUTATIVE OLIGOPEPTIDE UPTAKE ABC TRANSPORTER PERIPLASMIC SOLUTE-BINDING PROTEIN PRECURSOR from Rhizobium meliloti (Sinorhizobium meliloti) (532 aa),FASTA scores: opt: 209, E(): 7.7e-05, (22.85% identity in 460 aa overlap); P76128|YDDS_ECOLI|B1487|P77769|P76874 PUTATIVE ABC TRANSPORTER PERIPLASMIC BINDING PROTEIN from Escherichia coli strain K12 (516 aa), FASTA scores: opt: 182, E(): 0.0029, (20.0% identity in 315 aa overlap); etc. X2BLA5,P59984 No cell wall and cell processes Rv2585c NC_002945.3 Mycobrowser_v2 CDS 2880131 2881459 . - 0 Mb2617c secF PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN SECF Mb2617c, secF, len: 442 aa. Equivalent to Rv2586c,len: 442 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 442 aa overlap). Probable secF,protein-export membrane protein (integral membrane protein), equivalent to P38386|SECF_MYCLE|SECF|ML0488|MLCB1259.06|B1177_C3_239 PROTEIN-EXPORT MEMBRANE PROTEIN from Mycobacterium leprae (471 aa), FASTA scores: opt: 1910, E(): 2.9e-104, (72.15% identity in 456 aa overlap). Also similar to others e.g. Q9AE06|SECF from Corynebacterium glutamicum (Brevibacterium flavum) (403 aa), FASTA scores: opt: 1198,E(): 9.8e-63, (47.1% identity in 399 aa overlap); Q53956|SECF_STRCO|SCL2.05c from Streptomyces coelicolor (373 aa), FASTA scores: opt: 670, E(): 6.4e-32, (39.25% identity in 400 aa overlap); Q55611|SECF_SYNY3|SLR0775 from Synechocystis sp. strain PCC 6803 (315 aa), FASTA scores: opt: 416, E(): 3.8e-17, (33.8% identity in 296 aa overlap); etc. BELONGS TO THE SECD/SECF FAMILY, SECF FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c,SECE|Rv0638, SECF, SECG|Rv1440 AND SECY|Rv0732. Q7TYA1 No NC_002945.3 Mycobrowser_v2 CDS 2881463 2883184 . - 0 Mb2618c secD probable protein-export membrane protein secd Mb2618c, secD, len: 573 aa. Equivalent to Rv2587c,len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 573 aa overlap).Probable secD,protein-export membrane protein (integral membrane protein), equivalent to P38387|SECD_MYCLE|ML0487|MLCB1259.05|B1177_C1_164 PROTEIN-EXPORT MEMBRANE PROTEIN from Mycobacterium leprae (571 aa), FASTA scores: opt: 2948, E(): 2.6e-97, (80.6% identity in 583 aa overlap). Also similar to others e.g. Q9AE07|SECD from Corynebacterium glutamicum (Brevibacterium flavum) (637 aa), FASTA scores: opt: 1023,E(): 1.9e-29, (44.95% identity in 596 aa overlap); Q53955|SECD_STRCO from Streptomyces coelicolor (570 aa),FASTA scores: opt: 864, E(): 7.2e-24, (38.0% identity in 584 aa overlap); O33517|SECD_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (554 aa), FASTA scores: opt: 551, E(): 7.6e-13, (32.25% identity in 304 aa overlap); etc. Equivalent to AAK46977 from Mycobacterium tuberculosis strain CDC1551 (554 aa) but longer 19 aa. BELONGS TO THE SECD/SECF FAMILY, SECD FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Q7TYA0 No NC_002945.3 Mycobrowser_v2 CDS 2883294 2883641 . - 0 Mb2619c yajC PROBABLE CONSERVED MEMBRANE PROTEIN SECRETION FACTOR YAJC Mb2619c, -, len: 115 aa. Equivalent to Rv2588c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Probable yajC,secretion factor, a conserved membrane protein (see first citation below), equivalent to Q49647|YP88_MYCLE|ML0486|MLCB1259.04|B1177_C3_235 HYPOTHETICAL 12.8 KDA PROTEIN from Mycobacterium leprae (114 aa), FASTA scores: opt: 499, E(): 2.7e-26, (77.0% identity in 100 aa overlap). Also similar to other proteins e.g. Q9AE08 HYPOTHETICAL 13.5 KDA PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (121 aa), FASTA scores: opt: 222, E(): 5e-08, (39.8% identity in 103 aa overlap); Q9L292|SCL2.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 203, E(): 1.2e-06, (32.05% identity in 106 aa overlap); Q9CDT0|YWAB UNKNOWN PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (110 aa),FASTA scores: opt: 150, E(): 0.0026, (30.85% identity in 94 aa overlap); etc. X2BLD3,P65026 No cell wall and cell processes Rv2588c NC_002945.3 Mycobrowser_v2 CDS 2916099 2916920 . + 0 Mb2655 POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb2655, -, len: 273 aa. Equivalent to Rv2622, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Possible methyltransferase (EC 2.1.1.-), similar in part to others e.g. AAK75664|SP1578 PUTATIVE METHYLTRANSFERASE from Streptococcus pneumoniae (252 aa), FASTA scores: opt: 406,E(): 6.6e-18, (32.65% identity in 251 aa overlap); Q9F8B8 METHYLTRANSFERASE from Streptococcus agalactiae (254 aa),FASTA scores: opt: 381, E(): 2.3e-16, (31.75% identity in 252 aa overlap); Q9RJB6|SCF91.08 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (231 aa),FASTA scores: opt: 159, E(): 0.0091, (33.1% identity in 151 aa overlap); etc. Also similar in part to several hypothetical proteins e.g. Q99YR0|SPY1582 HYPOTHETICAL PROTEIN from Streptococcus pyogenes (251 aa), FASTA scores: opt: 397, E(): 2.3e-17, (36.3% identity in 248 aa overlap). Q7TY76 No intermediary metabolism and respiration Rv2622 NC_002945.3 Mycobrowser_v2 CDS 2883808 2885157 . + 0 Mb2620 gabT 4-AMINOBUTYRATE AMINOTRANSFERASE GABT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEMIALDEHYDE TRANSAMINASE) (GABA AMINOTRANSFERASE) (GABA-AT) Mb2620, gabT, len: 449 aa. Equivalent to Rv2589,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable gabT,4-aminobutyrate aminotransferase (EC 2.6.1.9), equivalent to P40829|GABT_MYCLE|ML0485|MLCB1259.03c|B1177_F2_67 4-AMINOBUTYRATE AMINOTRANSFERASE (446 aa), FASTA scores: opt: 2468, E(): 4.5e-141, (83.75% identity in 449 aa overlap). Also highly similar to others e.g. O86823|GABT from Streptomyces coelicolor (444 aa), FASTA scores: opt: 1832, E(): 8e-103, (63.9% identity in 443 aa overlap); AAK79395|CAC1427 from Clostridium acetobutylicum (445 aa),FASTA scores: opt: 1283, E(): 8.4e-70, (45.75% identity in 433 aa overlap); Q9KE66|BH0991 from Bacillus halodurans (443 aa), FASTA scores: opt: 1224, E(): 2.9e-66, (44.55% identity in 431 aa overlap); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BL48,P63505 No intermediary metabolism and respiration Rv2589 NC_002945.3 Mycobrowser_v2 CDS 2885319 2888825 . + 0 Mb2621 fadD9 PROBABLE FATTY-ACID-CoA LIGASE FADD9 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb2621, fadD9, len: 1168 aa. Equivalent to Rv2590,len: 1168 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1168 aa overlap). Probable fadD9, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to O69484|FADD9 (alias Q9CCT4|FADD9|ML0484 but longer 14 aa) PUTATIVE ACYL-COA SYNTHETASE from Mycobacterium leprae (1174 aa), FASTA scores: opt: 5247,E(): 0, (68.0% identity in 1178 aa overlap); Q49651|LCLA|B1177_F1_23 PUTATIVE LONG-CHAIN-FATTY-ACID--COA LIGASE from Mycobacterium leprae (827 aa), FASTA scores: opt: 3170, E(): 7.1e-181,(63.9% identity in 770 aa overlap). N-terminal (700 residues) similar to other long chain fatty acid ligases. And C-terminus highly similar to C-terminus of Q9XCF2|PSTB PSTB PROTEIN from Mycobacterium avium (2552 aa), FASTA scores: opt: 2083, E(): 8.4e-116, (40.8% identity in 1150 aa overlap) (and weak similarity on N-terminus); Q49653|POL1|B1177_F2_70 POL1 PROTEIN from Mycobacterium leprae (400 aa), FASTA scores: opt: 2066, E(): 2e-115,(76.25% identity in 404 aa overlap). C-terminal part highly similar to polyketide synthases and peptides synthases (weak similarity on N-terminus) e.g. Q10896|Rv0101|MTCY251.20|NRP PROBABLE PEPTIDE SYNTHETASE from Mycobacterium tuberculosis (2512 aa), FASTA scores: opt: 1988, E(): 3.7e-110, (40.2% identity in 1181 aa overlap); etc. Contains PS00455 putative AMP-binding domain signature, and PS00061 Short-chain alcohol dehydrogenase family signature. SEEMS TO BELONG TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY, AND TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TY99 No NC_002945.3 Mycobrowser_v2 CDS 2888999 2890639 . + 0 Mb2622 PE_PGRS44 pe-pgrs family protein pe_pgrs44 Mb2622, PE_PGRS44, len: 546 aa. Equivalent to Rv2591, len: 543 aa, from Mycobacterium tuberculosis strain H37Rv, (99.1% identity in 546 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. O53845|Rv0834c|MTV043.26c from Mycobacterium tuberculosis (882 aa), FASTA scores: opt: 1813, E(): 5.8e-66, (55.3% identity in 568 aa overlap). Equivalent to AAK46982 from Mycobacterium tuberculosis strain CDC1551 (505 aa) but longer 38 aa. Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp in-frame insertion (*-ggcggcacc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (546 aa versus 543 aa). Q7TY98 No NC_002945.3 Mycobrowser_v2 CDS 2947718 2948470 . - 0 Mb2694c CONSERVED HYPOTHETICAL PROTEIN Mb2694c, -, len: 250 aa. Equivalent to Rv2675c,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Conserved hypothetical protein. C-terminus highly similar to Q50010|U1764Z from Mycobacterium leprae (69 aa), FASTA scores: opt: 284, E(): 4.6e-11, (68.25% identity in 63 aa overlap). Shows some similarity with Q9P3V6|SPAC1348.04 (alias Q9P3E7|Q9P7U5) HYPOTHETICAL 16.6 KDA PROTEIN from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 203, E(): 9.5e-06, (33.05% identity in 118 aa overlap); Q9ZSZ7|BMCT METHYL CHLORIDE TRANSFERASE from Batis maritima (230 aa), FASTA scores: opt: 197, E(): 3.3e-05, (28.85% identity in 156 aa overlap); P72459|STSG METHYLTRANSFERASE from Streptomyces griseus (253 aa),FASTA scores: opt: 194, E(): 5.5e-05, (24.45% identity in 229 aa overlap); etc. Also similar to various proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c HYPOTHETICAL 22.8 KDA PROTEIN (212 aa), FASTA scores: opt: 431, E(): 8.3e-20, (39.1% identity in 197 aa overlap); O06426|Rv0560c|MTCY25D10.39c HYPOTHETICAL 25.9 KDA PROTEIN (241 aa), FASTA scores: opt: 379, E(): 1.6e-16, (35.95% identity in 178 aa overlap); O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE (233 aa), FASTA scores: opt: 297, E(): 2e-11, (30.55% identity in 193 aa overlap); etc. Q7TY49 No conserved hypotheticals Rv2675c NC_002945.3 Mycobrowser_v2 CDS 2890656 2891690 . - 0 Mb2623c ruvB PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVB Mb2623c, ruvB, len: 344 aa. Equivalent to Rv2592c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable ruvB,Holliday junction binding protein (EC 3.6.1.-) (see first citation below), equivalent to P40833|RUVB_MYCLE|ML0483|B1177_C3_227 HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium leprae (349 aa), FASTA scores: opt: 2059, E(): 2.1e-106, (94.45% identity in 342 aa overlap). Also highly similar to others e.g. Q9AE09|RUVB from Corynebacterium glutamicum (Brevibacterium flavum) (363 aa), FASTA scores: opt: 1651,E(): 6.5e-84, (75.6% identity in 332 aa overlap); Q9L291|RUVB from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1530, E(): 3e-77, (68.2% identity in 343 aa overlap); P08577|RUVB_ECOLI|B1860|Z2912|ECS2570 from Escherichia coli strains K12 and O157:H7 (336 aa), FASTA scores: opt: 1284, E(): 1e-63, (55.45% identity in 330 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE RUVB FAMILY. X2BKW1,P66754 No NC_002945.3 Mycobrowser_v2 CDS 2891687 2892277 . - 0 Mb2624c ruvA PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVA Mb2624c, ruvA, len: 196 aa. Equivalent to Rv2593c,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable ruvA,Holliday junction binding protein (see citations below),equivalent to P40832|RUVA_MYCLE|ML0482|B1177_C2_188 HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium leprae (203 aa), FASTA scores: opt: 923, E(): 9.9e-50, (76.85% identity in 203 aa overlap). Also highly similar to others e.g. Q9L290|RUVA from Streptomyces coelicolor (201 aa) (201 aa), FASTA scores: opt: 549, E(): 8.2e-27, (47.55% identity in 204 aa overlap); Q9AE10|RUVA from Corynebacterium glutamicum (Brevibacterium flavum) (206 aa), FASTA scores: opt: 440, E(): 4e-20, (47.1% identity in 206 aa overlap); P08576|RUVA_ECOLI|B1861|Z2913|ECS2571 from Escherichia coli strains K12 and O157:H7 (203 aa),FASTA scores: opt: 312, E(): 2.8e-12, (34.85% identity in 201 aa overlap); etc. BELONGS TO THE RUVA FAMILY. X2BLD5,P66745 No NC_002945.3 Mycobrowser_v2 CDS 2892274 2892840 . - 0 Mb2625c ruvC PROBABLE CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE RUVC (HOLLIDAY JUNCTION NUCLEASE) (HOLLIDAY JUNCTION RESOLVASE) Mb2625c, ruvC, len: 188 aa. Equivalent to Rv2594c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Probable ruvC,Holliday junction resolvase (EC 3.1.22.4) (see citations below), equivalent to P40834|RUVC_MYCLE|ML0481|B1177_C3_226 CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE from Mycobacterium leprae (188 aa),FASTA scores: opt: 984, E(): 2.3e-55, (81.0% identity in 184 aa overlap). Also highly similar to others e.g. Q9AE11|RUVC from Corynebacterium glutamicum (Brevibacterium flavum) (221 aa), FASTA scores: opt: 713,E(): 3.6e-38, (56.9% identity in 188 aa overlap); Q9L289|RUVC_STRCO|SCL2.10c from Streptomyces coelicolor (188 aa), FASTA scores: opt: 704, E(): 1.2e-37, (60.65% identity in 178 aa overlap); P24239|RUVC_ECOLI|B1863 from Escherichia coli strain K12 (172 aa), FASTA scores: opt: 322, E(): 1.6e-13, (38.65% identity in 163 aa overlap); etc. BELONGS TO THE RUVC FAMILY. COFACTOR: MAGNESIUM. X2BL50,P66761 No NC_002945.3 Mycobrowser_v2 CDS 2892949 2893194 . + 0 Mb2626 vapb40 possible antitoxin vapb40 Mb2626, -, len: 81 aa. Equivalent to Rv2595, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing similarity with various bacterial proteins e.g. O28268|AF2011 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (86 aa), FASTA scores: opt: 120, E(): 0.13, (34.35% identity in 67 aa overlap); CAC46196|SMC01176 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (79 aa), FASTA scores: opt: 119, E(): 0.14, (33.35% identity in 63 aa overlap); P37554|SP5T_BACSU|SPOVT STAGE V SPORULATION PROTEIN T from Bacillus subtilis (178 aa), FASTA scores: opt: 104, E(): 2.9, (51.45% identity in 35 aa overlap); etc. Also similar to O07779|Rv0599c|MTCY19H5.23 hypothetical protein from Mycobacterium tuberculosis (78 aa), FASTA scores: opt: 160, E(): 0.00026, (35.8% identity in 81 aa overlap). X2BLB8 No virulence, detoxification, adaptation Rv2595 NC_002945.3 Mycobrowser_v2 CDS 2894443 2894937 . + 0 Mb2629 CONSERVED HYPOTHETICAL PROTEIN Mb2629, -, len: 164 aa. Equivalent to Rv2598, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins from Streptomyces coelicolor e.g. Q9X8S3|SCH10.34c (185 aa), FASTA scores: opt: 197, E(): 3.5e-06, (34.75% identity in 167 aa overlap); and Q9L088|SCC24.29c (172 aa), FASTA scores: opt: 149, E(): 0.0053, (37.65% identity in 146 aa overlap). Equivalent to AAK46988 from Mycobacterium tuberculosis strain CDC1551 (154 aa) but longer 10 aa. X2BLD8 No conserved hypotheticals Rv2598 NC_002945.3 Mycobrowser_v2 CDS 2894934 2895365 . + 0 Mb2630 PROBABLE CONSERVED MEMBRANE PROTEIN Mb2630, -, len: 143 aa. Equivalent to Rv2599, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 143 aa overlap). Probable conserved membrane protein, equivalent to Q9K536|2599 HYPOTHETICAL 15.0 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (143 aa), FASTA scores: opt: 691, E(): 1.7e-33, (68.55% identity in 143 aa overlap). Shows weak similarity with Q9L089|SCC24.28c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (131 aa), FASTA scores: opt: 130,E(): 0.52, (26.45% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7TY96 No cell wall and cell processes Rv2599 NC_002945.3 Mycobrowser_v2 CDS 2895447 2895848 . + 0 Mb2631 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2631, -, len: 133 aa. Equivalent to Rv2600, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable conserved integral membrane protein, equivalent (but shorter 18 aa) to Q9K537|YQ00_MYCPA HYPOTHETICAL PROTEIN RV2600 HOMOLOG from Mycobacterium paratuberculosis (151 aa), FASTA scores: opt: 543, E(): 4.2e-28, (62.9% identity in 132 aa overlap). Also some similarity with other hypothetical or membrane proteins e.g. Q9L090|SCC24.27c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (146 aa),FASTA scores: opt: 241, E(): 8.7e-09, (34.8% identity in 135 aa overlap); O58487|PH0773 HYPOTHETICAL 15.0 KDA PROTEIN from Pyrococcus horikoshii (138 aa), FASTA scores: opt: 116, E(): 0.84, (34.35% identity in 96 aa overlap); etc. Equivalent to AAK46990 from Mycobacterium tuberculosis strain CDC1551 (152 aa) but shorter 19 aa. X2BLC5,P68914 No cell wall and cell processes Rv2600 NC_002945.3 Mycobrowser_v2 CDS 2924356 2924895 . + 0 Mb2663 HYPOTHETICAL PROTEIN Mb2663, -, len: 179 aa. Equivalent to Rv2630, len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Hypothetical unknown protein. Q7TY68 No conserved hypotheticals Rv2630 NC_002945.3 Mycobrowser_v2 CDS 4055877 4056038 . - 0 Mb3703c CONSERVED HYPOTHETICAL PROTEIN Mb3703c, -, len: 53 aa. Equivalent to Rv3678A, len: 53 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 53 aa overlap). Conserved hypothetical protein, similar to SCH17.10|AL079353_10 conserved hypothetical protein from Streptomyces coelicolor (53 aa),FASTA scores: opt: 259, E(): 1.5e-13, (78.0% identity in 50 aa overlap). Q7TVY6 No conserved hypotheticals Rv3678A NC_002945.3 Mycobrowser_v2 CDS 2931048 2931704 . + 0 Mb2670 dedA POSSIBLE TRANSMEMBRANE PROTEIN DEDA Mb2670, dedA, len: 218 aa. Equivalent to Rv2637,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Possible dedA,transmembrane protein, equivalent to Q49642|YQ37_MYCLE|ML0467|MLCL581.27|B1177_C2_172/B1177_C1_ 140 HYPOTHETICAL 23.1 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN, BELONGS TO THE DEDA FAMILY) from Mycobacterium leprae (214 aa), FASTA scores: opt: 1160,E(): 4.4e-64, (82.75% identity in 209 aa overlap); and O69601|Y364_MYCLE|ML0287|MLCB4.30 HYPOTHETICAL PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) (222 aa), FASTA scores: opt: 292, E(): 6.6e-11, (32.25% identity in 189 aa overlap). Also highly similar to other membrane proteins e.g. CAC42863|SCBAC36F5.27c PUTATIVE INTEGRAL MEMBRANE from Streptomyces coelicolor (211 aa), FASTA scores: opt: 837, E(): 2.6e-44, (59.2% identity in 201 aa overlap); Q55705|Y232_SYNY3|SLR0232 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (218 aa),FASTA scores: opt: 415, E(): 1.9e-18, (37.85% identity in 206 aa overlap); Q9RV63|DR1167 DEDA PROTEIN from Deinococcus radiodurans (200 aa); P09548|DEDA_ECOLI|B2317|Z3579|ECS3201 DEDA PROTEIN (DSG-1 PROTEIN) from Escherichia coli strains K12 and O157:H7 (219 aa), BLAST scores: 178, E(): 1.8e-13, Identities = 53/175 (30%); etc. Also similar to O06314|Y364_MYCTU|Rv0364|MT0380|MTCY13E10.26 HYPOTHETICAL 24.5 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Mycobacterium tuberculosis (227 aa), FASTA scores: opt: 293, E(): 5.8e-11, (35.85% identity in 184 aa overlap). BELONGS TO THE DEDA FAMILY. X2BL80,P63912 No cell wall and cell processes Rv2637 NC_002945.3 Mycobrowser_v2 CDS 2895845 2897416 . + 0 Mb2632 speE probable spermidine synthase spee (putrescine aminopropyltransferase) (aminopropyltransferase) (spdsy) Mb2632, speE, len: 523 aa. Equivalent to Rv2601,len: 523 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 523 aa overlap). Probable speE,spermidine synthase (EC 2.5.1.16), highly similar to many e.g. Q9L091|SCC24.26c from Streptomyces coelicolor (531 aa), FASTA scores: opt: 1493, E(): 1.3e-79, (48.45% identity in 514 aa overlap); Q9X8S2|SCH10.33c from Streptomyces coelicolor (554 aa), FASTA scores: opt: 1045,E(): 1.7e-53, (40.55% identity in 525 aa overlap); P09158|SPEE_ECOLI|B0121 from Escherichia coli strain K12 (287 aa), FASTA scores: opt: 368, E(): 2.9e-14, (30.5% identity in 272 aa overlap); etc. X2BLT1,Q7TY95 No intermediary metabolism and respiration Rv2601 NC_002945.3 Mycobrowser_v2 CDS 2897801 2898241 . + 0 Mb2634 vapc41 possible toxin vapc41. contains pin domain. Mb2634, -, len: 146 aa. Equivalent to Rv2602, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Conserved hypothetical protein, some weak similarity with proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O50457|Rv1242|MTV006.14 (143 aa), FASTA scores: opt: 147, E(): 0.0021, (26.25% identity in 141 aa overlap); P95023|Rv2530c|MTCY159.26 (139 aa), FASTA scores: opt: 131, E(): 0.027, (33.35% identity in 135 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 125, E(): 0.072, (26.45% identity in 140 aa overlap). Q7TY93 No virulence, detoxification, adaptation Rv2602 NC_002945.3 Mycobrowser_v2 CDS 2898262 2899017 . - 0 Mb2635c highly conserved protein Mb2635c, -, len: 251 aa. Equivalent to Rv2603c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Highly conserved hypothetical protein, equivalent to Q49645|YQ03_MYCLE|ML0475|U1177B|B1177_C2_181 HYPOTHETICAL 26.6 KDA PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 1514, E(): 2.2e-84, (92.45% identity in 251 aa overlap). Also highly similar to Q9L288|SCL2.11c HYPOTHETICAL 26.8 KDA PROTEIN from Streptomyces coelicolor (250 aa), FASTA scores: opt: 1268, E(): 1.5e-69, (76.7% identity in 249 aa overlap); Q9AE12|YFCA HYPOTHETICAL STRUCTURAL PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (251 aa), FASTA scores: opt: 1231,E(): 2.6e-67, (72.9% identity in 251 aa overlap); O83487|Y474_TREPA|TP0474 HYPOTHETICAL PROTEIN from Treponema pallidum (245 aa), FASTA scores: opt: 780, E(): 4.4e-40, (47.75% identity in 245 aa overlap); P24237|YEBC_ECOLI|B1864 PROTEIN YEBC from Escherichia coli strain K12 (246 aa), FASTA scores: opt: 776, E(): 7.6e-40,(47.8% identity in 249 aa overlap); etc. X2BL55,P67178 No conserved hypotheticals Rv2603c NC_002945.3 Mycobrowser_v2 CDS 2899150 2899746 . - 0 Mb2636c snop probable glutamine amidotransferase snop Mb2636c, -, len: 198 aa. Equivalent to Rv2604c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 198 aa overlap). Conserved hypothetical protein, equivalent (but shorter 21 aa) to Q49637|HISH|B1177_C1_149 HISH PROTEIN (BELONGS TO THE YFL060C/YAAE/HI1648 FAMILY) (alias Q9CCT5|ML0474 HYPOTHETICAL PROTEIN 223 aa) from Mycobacterium leprae (219 aa), FASTA scores: opt: 1069, E(): 1.7e-60, (83.35% identity in 198 aa overlap). Also highly similar to hypothetical proteins or amidotransferases e.g. Q9L287|SCL2.12c HYPOTHETICAL 21.5 KDA PROTEIN from Streptomyces coelicolor (202 aa), FASTA scores: opt: 702,E(): 2.3e-37, (56.75% identity in 192 aa overlap); P37528|YAAE_BACSU HYPOTHETICAL 21.4 KDA PROTEIN from Bacillus subtilis (196 aa), FASTA scores: opt: 608, E(): 1.9e-31, (48.7% identity in 189 aa overlap); Q9KGN5|BH0023 AMIDOTRANSFERASE from Bacillus halodurans (196 aa), FASTA scores: opt: 583, E(): 7.4e-30, (48.7% identity in 195 aa overlap); etc. Also some similarity with several proteins from Mycobacterium tuberculosis e.g. O06589|HIS5_MYCTU|Rv1602|MT1638|MTCY336.02c AMIDOTRANSFERASE (EC 2.4.2.-) (206 aa), FASTA scores: opt: 154, E(): 0.00036, (30.6% identity in 193 aa overlap). X2BLD1,Q7TY92 No intermediary metabolism and respiration Rv2604c NC_002945.3 Mycobrowser_v2 CDS 2907416 2908069 . - 0 Mb2644c pgsA1 pi synthase pgsa1 (phosphatidylinositol synthase) (cdp-diacylglycerol--inositol-3-phosphatidyltransferase) Mb2644c, pgsA1, len: 217 aa. Equivalent to Rv2612c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Probable pgsA1 (previously known as pgsA), PI synthase/CDP-diacylglyceride--inositol phosphatidyltransferase (EC 2.7.8.11), transmembrane protein, equivalent to O07149|MLCL581.16c|PGSA|ML0454 PUTATIVE PHOSPHATIDYLTRANSFERASE from Mycobacterium leprae (239 aa), FASTA scores: opt: 1141, E(): 4.1e-70, (79.35% identity in 213 aa overlap); and Q9F7Y9|PGSA PHOSPHATIDYLINOSITOL SYNTHASE from Mycobacterium smegmatis (222 aa), FASTA scores: opt: 981, E(): 2.7e-59, (67.3% identity in 217 aa overlap) (see citation below). Also similar to other proteins e.g. Q9L282|SCL2.17c PUTATIVE MEMBRANE TRANSFERASE from Streptomyces coelicolor (241 aa), FASTA scores: opt: 564, E(): 4.9e-31, (43.4% identity in 212 aa overlap); Q9UYD0|PGSA-LIKE|PAB1041 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Pyrococcus abyssi (186 aa),FASTA scores: opt: 264, E(): 8.4e-11, (33.15% identity in 190 aa overlap); Q9HQS2|PGSA|VNG1030G CDP-DIACYLGLYCEROL-GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Halobacterium sp. strain NRC-1 (199 aa), FASTA scores: opt: 249, E(): 9.1e-10,(32.1% identity in 193 aa overlap); etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. Note that in M. smegmatis, the psgA homolog is essential to the survival of the bacteria and seems cannot be compensated by any other enzyme of M. smegmatis. Q7TY86 No NC_002945.3 Mycobrowser_v2 CDS 2899754 2900599 . - 0 Mb2637c tesB2 PROBABLE ACYL-COA THIOESTERASE II TESB2 (TEII) Mb2637c, tesB2, len: 281 aa. Equivalent to Rv2605c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 281 aa overlap). Probable tesB2,acyl-CoA thioesterase II (EC 3.1.2.-), highly similar to others e.g. Q98EG9|MLL4250 from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 563,E(): 3.9e-29, (47.75% identity in 287 aa overlap); CAC47767 from Rhizobium meliloti (Sinorhizobium meliloti) (294 aa), FASTA scores: opt: 553, E(): 1.8e-28, (49.3% identity in 280 aa overlap); P23911|TESB_ECOLI|B0452 from Escherichia coli strain K12 (285 aa), FASTA scores: opt: 487, E(): 3.1e-24, (41.9% identity in 277 aa overlap); etc. Also similar to O06135|TESB1|Rv1618|MTCY01B2.10 ACYL-COA THIOESTERASE II from Mycobacterium tuberculosis (300 aa), FASTA scores: opt: 425, E(): 1.1e-21, (34.9% identity in 278 aa overlap). BELONGS TO THE C/M/P THIOESTER HYDROLASE FAMILY. Q7TY91 No NC_002945.3 Mycobrowser_v2 CDS 3256659 3257258 . - 0 Mb2973c chorismate pyruvate lyase Mb2973c, -, len: 199 aa. Equivalent to Rv2949c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Conserved hypothetical protein, equivalent to Q9CD83|ML0133 HYPOTHETICAL PROTEIN from Mycobacterium leprae (210 aa),FASTA scores: opt: 797, E(): 7.4e-47, (62.55% identity in 195 aa overlap). Equivalent to AAK47348 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 13 aa. X2BMN6,Q7TXK6 No intermediary metabolism and respiration Rv2949c NC_002945.3 Mycobrowser_v2 CDS 2900628 2901527 . - 0 Mb2638c snzp possible pyridoxine biosynthesis protein snzp Mb2638c, -, len: 299 aa. Equivalent to Rv2606c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Conserved hypothetical protein, equivalent to O07145|YQ06_MYCLE|ML0450|MLCL581.12c HYPOTHETICAL 35.6 KDA PROTEIN from Mycobacterium leprae (307 aa), FASTA scores: opt: 1686, E(): 1.5e-95, (89.7% identity in 291 aa overlap). Also highly similar to other hypothetical proteins (or product of pyroA gene) e.g. Q9L286|SCL2.13c HYPOTHETICAL 32.2 KDA PROTEIN from Streptomyces coelicolor (303 aa), FASTA scores: opt: 1461, E(): 7.6e-82, (76.8% identity in 293 aa overlap); O14027|YEM4_SCHPO|SPAC29B12.04 HYPOTHETICAL 31.4 KDA PROTEIN from Schizosaccharomyces pombe (Fission yeast) (296 aa), FASTA scores: opt: 1318, E(): 3.8e-73, (70.35% identity in 290 aa overlap); Q9UW83|PYROA PROTEIN INVOLVED IN PYRIDOXINE BIOSYNTHESIS from Emericella nidulans (Aspergillus nidulans) (see citation below) (304 aa),FASTA scores: opt: 1288, E(): 2.6e-71, (67.9% identity in 302 aa overlap); etc. X2BKX8,P60795 No intermediary metabolism and respiration Rv2606c NC_002945.3 Mycobrowser_v2 CDS 2901655 2902329 . + 0 Mb2639 pdxH PROBABLE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE PDXH (PNP/PMP OXIDASE) (PYRIDOXINEPHOSPHATE OXIDASE) (PNPOX) (PYRIDOXINE 5'-PHOSPHATE OXIDASE) Mb2639, pdxH, len: 224 aa. Equivalent to Rv2607,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable pdxH,pyridoxinephosphate oxidase (EC 1.4.3.5), equivalent to O33065|PDXH_MYCLE|ML2131|MLCB57.46 PYRIDOXAMINE 5'-PHOSPHATE OXIDASE from Mycobacterium leprae (219 aa),FASTA scores: opt: 1038, E(): 8.3e-61, (67.1% identity in 219 aa overlap). Also similar to others e.g. Q9I4S5|PDXH|PA1049 from Pseudomonas aeruginosa (215 aa),FASTA scores: opt: 608, E(): 1.1e-32, (49.55% identity in 218 aa overlap); Q9K3V7|SCD10.19c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 600, E(): 3.9e-32,(42.3% identity in 234 aa overlap); P28225|PDXH_ECOLI|B1638 from Escherichia coli strain K12 (217 aa), FASTA scores: opt: 533, E(): 8.9e-28, (40.3% identity in 216 aa overlap); etc. BELONGS TO THE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE FAMILY. COFACTOR: FMN. X2BLE9,P65683 No intermediary metabolism and respiration Rv2607 NC_002945.3 Mycobrowser_v2 CDS 2902503 2904245 . + 0 Mb2640 PPE42 ppe family protein ppe42 Mb2640, PPE42, len: 580 aa. Equivalent to Rv2608,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 580 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O06828|Rv1430|MTCY493.24c from Mycobacterium tuberculosis (528 aa), FASTA scores: opt: 1004, E(): 5.9e-48, (56.05% identity in 307 aa overlap). Q7TY90 No NC_002945.3 Mycobrowser_v2 CDS 2904267 2905322 . - 0 Mb2641c PROBABLE CONSERVED MEMBRANE PROTEIN Mb2641c, -, len: 351 aa. Equivalent to Rv2609c,len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 351 aa overlap). Probable conserved membrane protein, equivalent to O07146|MLCL581.13c|ML0451 HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium leprae (349 aa), FASTA scores: opt: 1675, E(): 1.4e-95, (77.85% identity in 334 aa overlap). Also similar to hypothetical proteins: O69888|SC2E1.17|MUTT HYPOTHETICAL 19.4 KDA PROTEIN from Streptomyces coelicolor and Streptomyces lividans (172 aa), FASTA scores: opt: 345, E(): 3.5e-14,(44.7% identity in 161 aa overlap); Q9L285|SCL2.14c HYPOTHETICAL 19.8 KDA PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 179, E(): 0.00056, (43.25% identity in 171 aa overlap); and Q9RYE5|DR0004 MUTT/NUDIX FAMILY PROTEIN from Deinococcus radiodurans (350 aa),FASTA scores: opt: 153, E(): 0.037, (33.35% identity in 123 aa overlap). Contains PS00893 mutT domain signature. BELONGS TO THE MUTT/NUDIX FAMILY. Q7TY89 No cell wall and cell processes Rv2609c NC_002945.3 Mycobrowser_v2 CDS 2905322 2906458 . - 0 Mb2642c pimA ALPHA-MANNOSYLTRANSFERASE PIMA Mb2642c, pimA, len: 378 aa. Equivalent to Rv2610c,len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). pimA,alpha-mannosyltransferase (EC 2.4.1.-) (see citations below), equivalent to O07147|MLCL581.14c|ML0452 PUTATIVE GLYCOSYLTRANSFERASE from Mycobacterium leprae (374 aa),FASTA scores: opt: 2044, E(): 8.8e-118, (82.25% identity in 378 aa overlap). N-terminus (from aa 1 to 27) equivalent to Q9FY7 PUTATIVE ALPHA-MANNOSYL TRANSFERASE (FRAGMENT) from Mycobacterium smegmatis (27 aa), BLASTP scores: 57.4 bits (137), E(): 3e-8, Identities = 25/27 (92%), Positives = 27/27 (99%) (see citation below). Also highly similar to Q9L284|SCL2.15c PUTATIVE SUGAR TRANSFERASE from Streptomyces coelicolor (387 aa), FASTA scores: opt: 1222, E(): 1.8e-67, (52.95% identity in 376 aa overlap); and similar in part to various proteins e.g. Q9YA73|APE2066 LONG HYPOTHETICAL N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN from Aeropyrum pernix (392 aa), FASTA scores: opt: 434, E(): 3e-19, (31.5% identity in 378 aa overlap); Q9UZA1|PAB0827 GALACTOSYLTRANSFERASE OR LPS BIOSYNTHESIS RFBU RELATED PROTEIN from Pyrococcus abyssi (371 aa),FASTA scores: opt: 382, E(): 4.3e-16, (28.2% identity in 383 aa overlap); O26275|MTH173 LPS BIOSYNTHESIS RFBU RELATED PROTEIN from Methanothermobacter thermautotrophicus (382 aa), FASTA scores: opt: 372, E(): 1.8e-15, (28.4% identity in 391 aa overlap); etc. Shows also some similarity with O05313|Rv1212c|MTCI364.24c HYPOTHETICAL 41.5 KDA PROTEIN from Mycobacterium tuberculosis (387 aa), FASTA scores: opt: 232, E(): 1.1e -07, (28.4% identity in 402 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). X2BLU2,Q7TY88 No NC_002945.3 Mycobrowser_v2 CDS 3282623 3282793 . + 0 Mb2995 CONSERVED HYPOTHETICAL PROTEIN Mb2995, -, len: 56 aa. Equivalent to Rv2970A, len: 56 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 56 aa overlap). Conserved hypothetical protein, similar to C-terminal part of several oxidoreductases e.g. Rv2971|Z83018|MTCY349_22 from Mycobacterium tuberculosis (282 aa), FASTA scores: opt: 158, E(): 3.6e-06, (45.0% identity in 60 aa overlap). May represent a gene fragment. X2BM17 No conserved hypotheticals Rv2970A NC_002945.3 Mycobrowser_v2 CDS 2906469 2907419 . - 0 Mb2643c probable acyltransferase Mb2643c, -, len: 316 aa. Equivalent to Rv2611c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 316 aa overlap). Probable acyltransferase (EC 2.3.1.-) , equivalent to O07148|MLCL581.15c|ML0453 HYPOTHETICAL 35.4 KDA PROTEIN from Mycobacterium leprae (320 aa), FASTA scores: opt: 1529, E(): 5e-90, (71.45% identity in 312 aa overlap); and equivalent to Q9F7Y8 PUTATIVE ACYLTRANSFERASE from Mycobacterium smegmatis (303 aa), FASTA scores: opt: 1464,E(): 6.5e-86, (72.15% identity in 291 aa overlap) (see citation below). Also highly similar to Q9L283|SCL2.16c PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (311 aa), FASTA scores: opt: 810, E(): 2.8e-44, (47.7% identity in 302 aa overlap); and similar to other acyltransferases e.g. Q9F0N3 ACYLTRANSFERASE from Campylobacter jejuni (295 aa), FASTA scores: opt: 207, E(): 6.4e-06, (20.45% identity in 220 aa overlap); Q9K379 ACYLTRANSFERASE (LIPID A BIOSYNTHESIS ACYLTRANSFERASE) from Campylobacter jejuni (295 aa), FASTA scores: opt: 203, E(): 1.1e-05, (20.0% identity in 220 aa overlap); etc. Q7TY87 No lipid metabolism Rv2611c NC_002945.3 Mycobrowser_v2 CDS 2913313 2913753 . - 0 Mb2650c PROBABLE TRANSMEMBRANE PROTEIN Mb2650c, -, len: 146 aa. Equivalent to Rv2617c,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Probable transmembrane protein, showing some similarity to hypothetical or membrane proteins e.g. CAC47207|SMC00744 PUTATIVE TRANSPORT PROTEIN TRANSMEMBRANE from Rhizobium meliloti (Sinorhizobium meliloti) (399 aa), FASTA scores: opt: 108, E(): 5.5, (29.15% identity in 144 aa overlap). Q7TY81 No cell wall and cell processes Rv2617c NC_002945.3 Mycobrowser_v2 CDS 2912796 2913296 . + 0 Mb2649 conserved protein Mb2649, -, len: 166 aa. Equivalent to Rv2616, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 166 aa overlap). Conserved hypothetical protein, highly similar to bacterial proteins: Q9L1G0|SC3D11.02c HYPOTHETICAL 20.3 KDA PROTEIN from Streptomyces coelicolor (188 aa), FASTA scores: opt: 407,E(): 2.3e-20, (44.0% identity in 159 aa overlap); Q9X945 A3(2) GLYCOGEN METABOLISM CLUSTER from Streptomyces coelicolor (134 aa), FASTA scores: opt: 330, E(): 2.5e-15,(46.65% identity in 120 aa overlap) (N-terminus shorter); Q9RST8|DR2035 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (198 aa), FASTA scores: opt: 228,E(): 2.4e-08, (35.1% identity in 168 aa overlap). Q7TY82 No conserved hypotheticals Rv2616 NC_002945.3 Mycobrowser_v2 CDS 2908066 2908653 . - 0 Mb2645c conserved protein Mb2645c, -, len: 195 aa. Equivalent to Rv2613c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). Conserved hypothetical protein, equivalent to Q9CCU0|ML0455 HYPOTHETICAL PROTEIN from Mycobacterium leprae (206 aa),FASTA scores: opt: 1074, E(): 7.4e-62, (84.7% identity in 196 aa overlap); and highly similar, but longer 18 aa, to O07150|MLCL581.17c HYPOTHETICAL 20.7 KDA PROTEIN from Mycobacterium leprae (186 aa), FASTA scores: opt: 1038,E(): 1.4e-59, (89.7% identity in 175 aa overlap). Also highly similar to other hypothetical proteins (often Hit family member) e.g. Q9F7Z0 from Mycobacterium smegmatis (see citation below) (205 aa), FASTA scores: opt: 975,E(): 1.6e-55, (79.35% identity in 184 aa overlap); Q9L279|SCL2.20 from Streptomyces coelicolor (186 aa),FASTA scores: opt: 638, E(): 5.8e-34, (52.85% identity in 176 aa overlap); Q9YFX8|APE0122 from Aeropyrum pernix (184 aa), FASTA scores: opt: 515, E(): 4.4e-26, (45.9% identity in 159 aa overlap); etc. It seems the Rv2613c and downstream ORF Rv2612c|psgA1 are expressed from the same promoter (see citation below) and that Rv2613c should be involved in lipid metabolism. Q7TY85 No lipid metabolism Rv2613c NC_002945.3 Mycobrowser_v2 CDS 2908646 2910724 . - 0 Mb2646c thrS PROBABLE THREONYL-TRNA SYNTHETASE THRS (THREONINE-TRNA SYNTHETASE)(ThrRS) (THREONINE-TRNA LIGASE) Mb2646c, thrS, len: 692 aa. Equivalent to Rv2614c,len: 692 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 692 aa overlap). Probable thrS,threonyl-tRNA synthetase (Threonine--tRNA ligase) (EC 6.1.1.3), equivalent to O07151|SYT_MYCLE|THRS|ML0456|MLCL581.18c THREONYL-TRNA SYNTHETASE from Mycobacterium leprae (702 aa), FASTA scores: opt: 3988, E(): 0, (84.05% identity in 702 aa overlap). Also highly similar to others e.g. Q9L278|THRS from Streptomyces coelicolor (658 aa), FASTA scores: opt: 1982, E(): 5.1e-114, (65.1% identity in 659 aa overlap); P56881|SYT_THETH|THRS from Thermus aquaticus (subsp. thermophilus) (659 aa), FASTA scores: opt: 1551, E(): 1.5e-87, (46.5% identity in 650 aa overlap); P00955|SYT_ECOLI from Escherichia coli (642 aa), FASTA scores: opt: 946, E(): 0, (40.7% identity in 612 aa overl ap); etc. Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. COFACTOR: BINDS 1 ZINC ION (BY SIMILARITY). X2BLE2,P67583 No NC_002945.3 Mycobrowser_v2 CDS 2910833 2911060 . + 0 Mb2647 CONSERVED HYPOTHETICAL PROTEIN Mb2647, -, len: 75 aa. Equivalent to Rv2614A, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 75 aa overlap). Conserved hypothetical protein. The region from aa 10-35 is similar to part of C-terminal part of several TRIOSEPHOSPHATE ISOMERASES (EC 5.3.1.1) e.g. P46711|TPIS_MYCLE|TPIA|TPI|ML0572|B1496_C1_127 from Mycobacterium leprae (261 aa), FASTA scores: opt: 112,E(): 0.95, (60.0% identity in 25 aa overlap); and O08408|TPIS_MYCTU|TPIA|TPI|Rv1438|MT1482|MTCY493.16c from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 104, E(): 3.3, (60.0% identity in 25 aa overlap); P19583|TPIS_CORGL|TPIA|TPI from Corynebacterium glutamicum (Brevibacterium flavum) (259 aa), FASTA scores: opt: 100,E(): 6, (45.45% identity in 33 aa overlap); etc. TRIOSEPHOSPHATE ISOMERASES PLAY AN IMPORTANT ROLE IN SEVERAL METABOLIC PATHWAYS (CATALYTIC ACTIVITY: D-GLYCERALDEHYDE 3-PHOSPHATE = DIHYDROXY-ACETONE PHOSPHATE). Q7TY84 No conserved hypotheticals Rv2614A NC_002945.3 Mycobrowser_v2 CDS 2911057 2912451 . - 0 Mb2648c PE_PGRS45 pe-pgrs family protein pe_pgrs45 Mb2648c, PE_PGRS45, len: 464 aa. Equivalent to Rv2615c, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 464 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. P71664|Rv1396c|MTCY21B4.13c from Mycobacterium tuberculosis (576 aa), FASTA scores: opt: 1629, E(): 4.8e-58, (56.65% identity in 482 aa overlap). Equivalent to AAK47006 from Mycobacterium tuberculosis strain CDC1551 (476 aa) but shorter 15 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). Q7TY83 No NC_002945.3 Mycobrowser_v2 CDS 2913900 2914577 . + 0 Mb2651 CONSERVED HYPOTHETICAL PROTEIN Mb2651, -, len: 225 aa. Equivalent to Rv2618, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Conserved hypothetical protein, similar in part to Q9EWQ9|SC4C2.03 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (159 aa), FASTA scores: opt: 235, E(): 1.3e-07,(43.7% identity in 103 aa overlap); Q9HLM6|TA0201 HYPOTHETICAL PROTEIN from Thermoplasma acidophilum (215 aa), FASTA scores: opt: 164, E(): 0.0038, (23.4% identity in 201 aa overlap); and to mycobacterial proteins e.g. O06191|Rv2621c|MTCY01A10.11 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium tuberculosis (224 aa), FASTA scores: opt: 149, E(): 0.033, (28.05% identity in 196 aa overlap). Q7TY80 No conserved hypotheticals Rv2618 NC_002945.3 Mycobrowser_v2 CDS 2914562 2914915 . - 0 Mb2652c conserved protein Mb2652c, -, len: 117 aa. Equivalent to Rv2619c,len: 117 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 117 aa overlap). Conserved hypothetical protein, highly similar to Q9L0F3|SCD31.14 HYPOTHETICAL 11.6 KDA PROTEIN from Streptomyces coelicolor (110 aa) , FASTA scores: opt: 407, E(): 2.3e-21, (55.95% identity in 109 aa overlap). Also similarity with other short bacterial hypothetical proteins e.g. Q9F8B9 HYPOTHETICAL 12.4 KDA PROTEIN from Streptococcus agalactiae (112 aa), FASTA scores: opt: 143, E(): 0.0032,(32.45% identity in 74 aa overlap); etc. Q7TY79 No conserved hypotheticals Rv2619c NC_002945.3 Mycobrowser_v2 CDS 2914928 2915353 . - 0 Mb2653c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2653c, -, len: 141 aa. Equivalent to Rv2620c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Probable conserved transmembrane protein, highly similar to O54184|SC7H1.25 HYPOTHETICAL 14.6 KDA PROTEIN from Streptomyces coelicolor (144 aa), FASTA scores: opt: 459, E(): 1.4e-22, (56.45% identity in 140 aa overlap). Q7TY78 No cell wall and cell processes Rv2620c NC_002945.3 Mycobrowser_v2 CDS 2915350 2916021 . - 0 Mb2654c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb2654c, -, len: 223 aa. Equivalent to Rv2621c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Possible transcriptional regulator, similar in part to Q49688|MLCL536.29c|ML0592 PUTATIVE DNA-BINDING PROTEIN from Mycobacterium leprae (254 aa), FASTA scores: opt: 168, E(): 0.0018, (29.75% identity in 222 aa overlap). Shows similarity with Q9XAD0|SCC22.08c PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (252 aa),FASTA scores: opt: 148, E(): 0.032, (29.4% identity in 204 aa overlap); and Q9RVM8|DR0999 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (225 aa), FASTA scores: opt: 195, E(): 3.3e-05, (29.6% identity in 213 aa overlap). Also some similarity with O06195|Rv2618|MTCY01A10.15c from Mycobacterium tuberculosis (225 aa), FASTA scores: opt: 149, E(): 0.025,(28.95% identity in 197 aa overlap). Contains helix-turn-helix motif at aa 31-52 (Score 1662, +4.85 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (ggg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa). Q7TY77 No regulatory proteins Rv2621c NC_002945.3 Mycobrowser_v2 CDS 3288299 3288505 . - 0 Mb2999A Mb2999A HYPOTHETICAL PROTEIN Mb2999A, -, len: 68 aa. Identified by de novo proteomics from Mycobacterium bovis strain 2212/97 under exponential conditions. Mb2999A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BM20 No NC_002945.3 Mycobrowser_v2 CDS 2920970 2922211 . - 0 Mb2660c conserved protein Mb2660c, -, len: 413 aa. Equivalent to Rv2627c,len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 413 aa overlap). Conserved hypothetical protein. Some similarity in C-terminal part of O53697|Rv0293c|MTV035.21c HYPOTHETICAL 44.0 KDA PROTEIN from Mycobacterium tuberculosis (400 aa), FASTA scores: opt: 392, E(): 1.9e-17, (31.1% identity in 299 aa overlap). Q7TY71 No conserved hypotheticals Rv2627c NC_002945.3 Mycobrowser_v2 CDS 2917056 2917949 . + 0 Mb2656 TB31.7 universal stress protein family protein tb31.7 Mb2656, TB31.7, len: 297 aa. Equivalent to Rv2623,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 297 aa overlap). TB31.7, conserved hypothetical protein, highly similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA scores: opt: 1076, E(): 1.4e-60, (55.25% identity in 295 aa overlap); O53472|Rv2026c|MTV018.13c (294 aa), FASTA scores: opt: 988, E(): 4.8e-55, (51.5% identity in 295 aa overlap); Q10862|YJ96_MYCTU|Rv1996|MT2052|MTCY39.23c (317 aa), FASTA scores: opt: 688, E(): 4.1e-36, (45.1% identity in 315 aa overlap); etc. Also similar to several Streptomyces proteins e.g. Q9RIZ8|SCJ1.16c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (294 aa), FASTA scores: opt: 407, E(): 2e-18, (32.65% identity in 303 aa overlap); and other bacterial hypothetical proteins e.g. Q9HPP5|VNG1536 from Halobacterium sp (147 aa), FASTA scores: opt: 180, E(): 0.00022, (31.65% identity in 139 aa overlap). Q7TY75 No NC_002945.3 Mycobrowser_v2 CDS 2917952 2918770 . - 0 Mb2657c universal stress protein family protein Mb2657c, -, len: 272 aa. Equivalent to Rv2624c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, similar to several Streptomyces proteins e.g. Q9RIY5|SCJ1.29c HYPOTHETICAL 30.1 KDA PROTEIN from Streptomyces coelicolor (283 aa), FASTA scores: opt: 260, E(): 5e-09, (32.05% identity in 290 aa overlap). Also similar to Mycobacterium tuberculosis proteins O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 563, E(): 7e-28, (36.85% identity in 266 aa overlap); P95192|Rv3134c|MTCY03A2.240 (268 aa), FASTA scores: opt: 458, E(): 2.3e-21, (36.55% identity in 271 aa overlap); Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA scores: opt: 199, E(): 3.2e-05, (29.35% identity in 286 aa overlap); etc. Q7TY74 No virulence, detoxification, adaptation Rv2624c NC_002945.3 Mycobrowser_v2 CDS 2918785 2919966 . - 0 Mb2658c PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN Mb2658c, -, len: 393 aa. Equivalent to Rv2625c,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Probable conserved transmembrane ala-, leu-rich protein, similar to many hypothetical or membrane proteins e.g. Q55518|Y528_SYNY3|SLL0528 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (379 aa),FASTA scores: opt: 552, E(): 5.6e-26, (30.75% identity in 374 aa overlap); Q9RJ56|SCI41.35c HYPOTHETICAL 39.8 KDA PROTEIN from Streptomyces coelicolor (374 aa), FASTA scores: opt: 419, E(): 5.7e-18, (31.6% identity in 383 aa overlap); CAC49448|SMB20925 CONSERVED HYPOTHETICAL MEMBRANE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (372 aa), FASTA scores: opt: 401, E(): 6.9e-17,(29.5% identity in 383 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q7TY73 No cell wall and cell processes Rv2625c NC_002945.3 Mycobrowser_v2 CDS 2920025 2920456 . - 0 Mb2659c hrp1 hypoxic response protein 1 hrp1 Mb2659c, -, len: 143 aa. Equivalent to Rv2626c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein, similar to CAC49670|SMB21441 PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE PROTEIN (EC 1.1.1.205) from Rhizobium meliloti (Sinorhizobium meliloti) (120 aa), FASTA scores: opt: 287, E(): 6.6e-12,(43.75% identity in 112 aa overlap) (has its N-terminus shorter 27 aa); AAK78655|CAC0678 CBS DOMAINS from Clostridium acetobutylicum (142 aa), FASTA scores: opt: 276, E(): 3.9e-11, (35.65% identity in 115 aa overlap); Q9K9P0|BH2605 BH2605 PROTEIN from Bacillus halodurans (142 aa), FASTA scores: opt: 276, E(): 3.9e-11, (35.65% identity in 115 aa overlap); etc. Also some similarity to P71737|Rv2406c|MTCY253.14 HYPOTHETICAL 15.1 KDA PROTEIN from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 145, E(): 0.00012, (22.3% identity in 112 aa overlap). Q7TY72 No conserved hypotheticals Rv2626c NC_002945.3 Mycobrowser_v2 CDS 2925034 2926332 . + 0 Mb2664 CONSERVED HYPOTHETICAL PROTEIN Mb2664, -, len: 432 aa. Equivalent to Rv2631, len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Conserved hypothetical protein, highly similar to several conserved hypothetical proteins from various species e.g. O29399|AF0862 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (482 aa), FASTA scores: opt: 1496,E(): 2.1e-80, (52.3% identity in 438 aa overlap) (has its N-terminus longer 38 aa); O27634|MTH1597 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (488 aa),FASTA scores: opt: 1428, E(): 2.1e-76, (50.9% identity in 438 aa overlap); Q9YB37|APE1758 HYPOTHETICAL 53.7 KDA PROTEIN APE1758 from Aeropyrum pernix (483 aa), FASTA scores: opt: 1422, E(): 4.6e-76, (49.3% identity in 440 aa overlap) (has its N-terminus longer 38 aa); etc. Equivalent to AAK47022 from Mycobacterium tuberculosis strain CDC1551 (432 aa) but longer 8 aa. 3' part extended since first submission (+175 aa). X2BLH6,P59975 No conserved hypotheticals Rv2631 NC_002945.3 Mycobrowser_v2 CDS 2926371 2926652 . - 0 Mb2665c conserved protein Mb2665c, -, len: 93 aa. Equivalent to Rv2632c, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis: P71996|YH38_MYCTU|Rv1738|MT1780|MTCY04C12.23 (94 aa),FASTA scores: opt: 319, E(): 4.2e-15, (53.95% identity in 89 aa overlap); and Q9KK61 from Mycobacterium bovis BCG (56 aa), FASTA scores: opt: 178, E(): 9.2e-06, (52.95% identity in 51 aa overlap). X2BL77 No conserved hypotheticals Rv2632c NC_002945.3 Mycobrowser_v2 CDS 2926797 2927282 . - 0 Mb2666c HYPOTHETICAL PROTEIN Mb2666c, -, len: 161 aa. Equivalent to Rv2633c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Hypothetical unknown protein. X2BLF5 No conserved hypotheticals Rv2633c NC_002945.3 Mycobrowser_v2 CDS 2927567 2929903 . - 0 Mb2667c PE_PGRS46 pe-pgrs family protein pe_pgrs46 Mb2667c, PE_PGRS46, len: 778 aa. Equivalent to Rv2634c, len: 778 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 778 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. O53553|YZ08_MYCTU|Rv3508|MTV023.15 from Mycobacterium tuberculosis (1901 aa), FASTA scores: opt: 2553, E(): 2.2e-93, (53.8% identity in 866 aa overlap). Equivalent to AAK47026 from Mycobacterium tuberculosis strain CDC1551 (788 aa) but shorter 10 aa. X2BLW7 No NC_002945.3 Mycobrowser_v2 CDS 2929932 2930174 . + 0 Mb2668 HYPOTHETICAL PROTEIN Mb2668, -, len: 80 aa. Equivalent to Rv2635, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Hypothetical unknown protein. X2BL23 No conserved hypotheticals Rv2635 NC_002945.3 Mycobrowser_v2 CDS 2930175 2930852 . + 0 Mb2669 CONSERVED HYPOTHETICAL PROTEIN Mb2669, -, len: 225 aa. Equivalent to Rv2636, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Conserved hypothetical protein, showing some similarity with various proteins: Q98FG2|MLL3789 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (239 aa), FASTA scores: opt: 304, E(): 3.7e-13, (31.55% identity in 187 aa overlap); CAC46568|SMC04451 PUTATIVE CHLORAMPHENICOL PHOSPHOTRANSFERASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (220 aa), FASTA scores: opt: 175,E(): 0.00014, (28.0% identity in 225 aa overlap); Q56148|CPT_STRVL CHLORAMPHENICOL 3-O PHOSPHOTRANSFERASE (EC 2.7.1.-) from Streptomyces violaceus (Streptomyces venezuelae) (178 aa), FASTA scores: opt: 131, E(): 0.1,(31.75% identity in 170 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Translational start site uncertain, chosen by similarity. X2BLI1,P65040 No conserved hypotheticals Rv2636 NC_002945.3 Mycobrowser_v2 CDS 2931867 2932313 . + 0 Mb2671 CONSERVED HYPOTHETICAL PROTEIN Mb2671, -, len: 148 aa. Equivalent to Rv2638, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Conserved hypothetical protein, similar in part to Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa), FASTA scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa overlap); and showing weak similarity with various proteins e.g. O69205 HYPOTHETICAL 13.4 KDA PROTEIN from Actinosynnema pretiosum (subsp. auranticum) (128 aa),FASTA scores: opt: 157, E(): 0.0016, (29.8% identity in 114 aa overlap); Q9RJ93|SCF91.32 PUTATIVE ANTI-SIGMA FACTOR ANTAGONIST from Streptomyces coelicolor (183 aa),FASTA scores: opt: 148, E(): 0.0082, (30.85% identity in 107 aa overlap); etc. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis: O07728|Rv1904|MTCY180.14c (143 aa), FASTA scores: opt: 456, E(): 3.9e-23, (52.8% identity in 125 aa overlap); and Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128 aa),FASTA scores: opt: 435, E(): 8.6e-22, (53.6% identity in 125 aa overlap). Q7TY67 No conserved hypotheticals Rv2638 NC_002945.3 Mycobrowser_v2 CDS 2932488 2932820 . - 0 Mb2672c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2672c, -, len: 110 aa. Equivalent to Rv2639c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Probable conserved integral membrane protein, highly similar to many bacterial hypothetical or membrane proteins e.g. Q9X889|YE14_STRCO|SCE15.14 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 597, E(): 3.1e-31, (73.15% identity in 108 aa overlap); Q55939|Y793_SYNY3|SLL0793 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (108 aa), FASTA scores: opt: 341, E(): 4.9e-15, (51.4% identity in 109 aa overlap); O31553|YFJF_BACSU POTENTIAL INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (109 aa),FASTA scores: opt: 334, E(): 1.4e-14, (47.5% identity in 109 aa overlap); etc. X2BLX0,P67147 No cell wall and cell processes Rv2639c NC_002945.3 Mycobrowser_v2 CDS 2932940 2933299 . - 0 Mb2673c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY) Mb2673c, -, len: 119 aa. Equivalent to Rv2640c,len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 aa), FASTA scores: opt: 261, E(): 5.6e-10, (47.75% identity in 103 aa overlap); Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (122 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity in 116 aa overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity in 116 aa overlap); P77295|YGAV_ECOLI|B2667 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 (99 aa), FASTA scores: opt: 156, E(): 0.0023, (34.1% identity in 88 aa overlap); etc. Also similar to upstream ORF P71941|Rv2642|MTCY441.12 PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (126 aa), FASTA scores: opt: 237, E(): 2e-08,(38.55% identity in 109 aa overlap). Contains helix-turn-helix motif at aa 59-80 (Score 1166, +3.16 SD). BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TY66 No regulatory proteins Rv2640c NC_002945.3 Mycobrowser_v2 CDS 2933401 2933859 . + 0 Mb2674 cadI CADMIUM INDUCIBLE PROTEIN CADI Mb2674, cadI, len: 152 aa. Equivalent to Rv2641,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). cadI, conserved hypothetical protein. Gene induced by cadmium (see first citation below), highly similar to hypothetical proteins e.g. Q9L222|SC1A2.19c from Streptomyces coelicolor (152 aa), FASTA scores: opt: 509, E(): 2.3e-27, (55.05% identity in 149 aa overlap); P45945|YQCK_BACSU from Bacillus subtilis (146 aa), FASTA scores: opt: 295, E(): 5.4e-13, (33.55% identity in 146 aa overlap); and Q98CF8|MLL5167 from Rhizobium loti (Mesorhizobium loti) (124 aa), FASTA scores: opt: 110, E(): 1.3, (31.4% identity in 121 aa overlap). Some similarity with Q10548|Y887_MYCTU|Rv0887c|MT0910|MTCY31.15c from Mycobacterium tuberculosis (152 aa), FASTA scores: opt: 108, E(): 2.1, (25.7% identity in 148 aa overlap). X2BLI3 No conserved hypotheticals Rv2641 NC_002945.3 Mycobrowser_v2 CDS 2933995 2934375 . + 0 Mb2675 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY) Mb2675, -, len: 126 aa. Equivalent to Rv2642, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (122 aa), FASTA scores: opt: 390, E(): 3.7e-19, (56.55% identity in 122 aa overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa),FASTA scores: opt: 378, E(): 2.3e-18, (59.8% identity in 97 aa overlap); Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 aa), FASTA scores: opt: 359, E(): 4.1e-17, (56.9% identity in 116 aa overlap); P52144|ARR2_ECOLI|ARSR from Escherichia coli (117 aa), FASTA scores: opt: 202, E(): 1e-06, (39.8% identity in 88 aa overlap); etc. Also similar to downstream ORF P71939|Rv2640c|MTCY441.10c PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (119 aa), FASTA scores: opt: 237, E(): 5e-09, (38.55% identity in 109 aa overlap); and others from Mycobacterium tuberculosis e.g. O05840|Rv2358|MTCY27.22c. Contains PS00846 Bacterial regulatory proteins, arsR family signature. Contains helix-turn-helix motif at aa 58-79 (Score 1112, +2.97 SD). BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TY65 No regulatory proteins Rv2642 NC_002945.3 Mycobrowser_v2 CDS 2939550 2940353 . + 0 Mb2685 probable transposase for insertion sequence element is1081 (fragment) Mb2685, -, len: 267 aa. Equivalent to Rv2666, len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 267 aa overlap). Transposase (fragment), identical in region of overlap to P35882|TRA1_MYCBO|TRA1_MYCTU TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081 from Mycobacterium tuberculosis or bovis (415 aa). Last 4 codons not part of gene. Contains PS01007 Transposases, Mutator family, signature. Q7TY56 No insertion seqs and phages Rv2666 NC_002945.3 Mycobrowser_v2 CDS 2934372 2935868 . + 0 Mb2676 arsC PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSC Mb2676, arsC, len: 498 aa. Equivalent to Rv2643,len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 498 aa overlap). Probable arsC,arsenical resistance transport integral membrane protein,highly similar or similar to others e.g. Q9L1X4|SC3D9.05 POSSIBLE ARSENIC RESISTANCE MEMBRANE TRANSPORT PROTEIN from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (74.3% identity in 358 aa overlap); Q9X8Y0|SCH35.26 PUTATIVE HEAVY METAL RESISTANCE MEMBRANE PROTEIN from Streptomyces coelicolor (369 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (73.8% identity in 359 aa overlap); Q06598|ACR3_YEAST|ACR3|YPR201W|P9677.2 ARSENICAL-RESISTANCE PROTEIN from Saccharomyces cerevisiae (Baker's yeast) (404 aa), FASTA scores: opt: 591, E(): 4e-28, (36.6% identity in 380 aa overlap); etc. BELONGS TO THE ACR3 FAMILY. Q7TY64 No cell wall and cell processes Rv2643 NC_002945.3 Mycobrowser_v2 CDS 2935995 2936312 . - 0 Mb2677c HYPOTHETICAL PROTEIN Mb2677c, -, len: 105 aa. Equivalent to Rv2644c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Hypothetical unknown protein. X2BLX4 No conserved hypotheticals Rv2644c NC_002945.3 Mycobrowser_v2 tRNA 2936959 2937030 . - 0 valT valT tRNA-Val valT, len: 72 nt. Equivalent to valT, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Val, anticodon cac. No NC_002945.3 Mycobrowser_v2 tRNA 2937215 2937287 . + 0 glyT glyT tRNA-Gly glyT, len: 73 nt. Equivalent to glyT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Gly, anticodon gcc. No NC_002945.3 Mycobrowser_v2 tRNA 2937317 2937387 . + 0 cysU cysU tRNA-Cys cysU, len: 71 nt. Equivalent to cysU, len: 71 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 nt overlap). tRNA-Cys, anticodon gca. No NC_002945.3 Mycobrowser_v2 CDS 2939178 2939459 . + 0 Mb2684 HYPOTHETICAL ARGININE RICH PROTEIN Mb2684, -, len: 93 aa. Equivalent to Rv2665, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Hypothetical arg-rich protein, showing some similarity to N-terminus of P71640|Rv2811|MTCY16B7.32c HYPOTHETICAL 21.1 KDA PROTEIN from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 157, E(): 0.0011, (37.5% identity in 72 aa overlap); and also to part of O35132|CP2B_RAT|CYP27B1|CYP27B 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus (Rat) (501 aa), FASTA scores: opt: 106, E(): 5.4, (34.5% identity in 87 aa overlap). Q7TY57 No conserved hypotheticals Rv2665 NC_002945.3 Mycobrowser_v2 CDS 3034732 3035559 . - 0 Mb2791c PE27 pe family protein pe27 Mb2791c, PE27, len: 275 aa. Equivalent to Rv2769c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 275 aa overlap). Member of the Mycobacterium tuberculosis PE family, highly similar to many (notably in N-terminal part) e.g. P96361|Rv1040c|MTCY10G2.09 from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 1111, E(): 5.9e-52, (68.55% identity in 283 aa overlap). Q7TXX4 No NC_002945.3 Mycobrowser_v2 CDS 2940375 2941133 . + 0 Mb2686 clpX' possible atp-dependent protease atp-binding subunit clpc2 Mb2686, clpX', len: 252 aa. Equivalent to Rv2667,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Possible clpX',ATP-dependent protease atp-binding subunit (EC 3.4.-.-),highly similar to Q9X8L2|SCE9.40 HYPOTHETICAL 27.3 KDA PROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 877, E(): 2.2e-46, (57.25% identity in 255 aa overlap). The second half of the protein is highly similar to N-terminal of several CLP-FAMILY proteins e.g. P24428|CLPC_MYCLE|ML0235 PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium leprae (848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); O06286|CLPC_MYCTU|Rv3596c|MT3703|MTCY07H7B.26 PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); Q9S6T8|SCE94.24c PUTATIVE CLP-FAMILY ATP-BINDING PROTEASE from Streptomyces coelicolor (841 aa), FASTA scores: opt: 303, E(): 5.6e-11, (38.8% identity in 152 aa overlap); etc. Some weak similarity to nearby P71961|MTCY441.33|Rv2664 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (83 aa). X2BLH2,P0A525 No NC_002945.3 Mycobrowser_v2 CDS 2941212 2941733 . + 0 Mb2687 POSSIBLE EXPORTED ALANINE AND VALINE RICH PROTEIN Mb2687, -, len: 173 aa. Equivalent to Rv2668, len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 173 aa overlap). Hypothetical ala-,val-rich protein, possibly exported. Equivalent to AAK47057 from Mycobacterium tuberculosis strain CDC1551 (208 aa) but N-terminal part shorter 35 aa and with few differences. Has potential signal peptide sequence. Q7TY55 No cell wall and cell processes Rv2668 NC_002945.3 Mycobrowser_v2 CDS 2941762 2942232 . + 0 Mb2688 gcn5-related n-acetyltransferase Mb2688, -, len: 156 aa. Equivalent to Rv2669, len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, showing some similarity to various proteins e.g. Q9A6M0|CC2073 ACETYLTRANSFERASE (GNAT FAMILY) from Caulobacter crescentus (178 aa), FASTA scores: opt: 242, E(): 1.2e-09, (30.9% identity in 165 aa overlap); Q99RQ8|SA2159 hypothetical protein similar to transcription repressor of sporulation, septation and degradation paiA from Staphylococcus aureus subsp. aureus N315 (171 aa), FASTA scores: opt: 214, E(): 9.8e-08,(27.5% identity in 160 aa overlap); BAB58531|SAV2369 HYPOTHETICAL 20.1 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (171 aa), FASTA scores: opt: 214, E(): 9.8e-08, (27.5% identity in 160 aa overlap); P21340|PAIA_BACSU|O32112 PROTEASE SYNTHASE AND SPORULATION from Bacillus subtilis (171 aa), FASTA scores: opt: 209,E(): 2.1e-07, (22.85% identity in 162 aa overlap); etc. X2BL47,P63426 No intermediary metabolism and respiration Rv2669 NC_002945.3 Mycobrowser_v2 CDS 2942210 2943319 . - 0 Mb2689c CONSERVED HYPOTHETICAL PROTEIN Mb2689c, -, len: 369 aa. Equivalent to Rv2670c,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Conserved hypothetical protein, equivalent, but longer 164 aa, to O05683|MLC1351.22c HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 847,E(): 1.2e-45, (82.4% identity in 159 aa overlap). And highly similar to Q9X824|SC9B1.04c PUTATIVE ATP/GTP-BINDING INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (350 aa), FASTA scores: opt: 1169,E(): 2e-65, (56.85% identity in 343 aa overlap); and Q9RWB0|DR0759 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (351 aa), FASTA scores: opt: 859,E(): 4e-46, (45.9% identity in 331 aa overlap). Also some similarity with other proteins e.g. P46442|YHCM_ECOLI|AAG58360|BAB37528 HYPOTHETICAL PROTEIN from Escherichia coli strains K12 and O157:H7 (375 aa),FASTA scores: opt: 237, E(): 2.1e-07, (28.0% identity in 325 aa overlap); Q9JRK2|NMA1520|NMB1306 PUTATIVE NUCLEOTIDE-BINDING PROTEIN from Neisseria meningitidis (serogroup A and B) (383 aa), FASTA scores: opt: 221, E(): 2.1e-06, (27.8% identity in 356 aa overlap); Q9HVX7|PA4438 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (364 aa),FASTA scores: opt: 211, E(): 8.5e-06, (28.9% identity in 353 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TY54 No conserved hypotheticals Rv2670c NC_002945.3 Mycobrowser_v2 CDS 2944161 2945747 . + 0 Mb2691 POSSIBLE SECRETED PROTEASE Mb2691, -, len: 528 aa. Equivalent to Rv2672, len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 528 aa overlap). Possible secreted protease (EC 3.4.-.-), equivalent to O05685|MLC1351.24|ML1339 PUTATIVE SECRETED PROTEASE from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722,E(): 9.4e-140, (74.45% identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE PROTEINASE from Streptomyces lividans (513 aa), FASTA scores: opt: 429,E(): 6.8e-16, (26.2% identity in 538 aa overlap); Q9FCK9|2SC3B6.03c PEPTIDASE from Streptomyces coelicolor (513 aa), FASTA scores: opt: 421, E(): 1.8e-15, (26.45% identity in 541 aa overlap); Q10508|YM23_MYCTU from Mycobacterium tuberculosis (520 aa), FASTA scores: opt: 349, E(): 1.4e-11, (26.6% identity in 523 aa overlap); etc. Equivalent to AAK47061 from Mycobacterium tuberculosis strain CDC1551 (518 aa) but longer 10 aa. Q7TY52 No intermediary metabolism and respiration Rv2672 NC_002945.3 Mycobrowser_v2 CDS 2945770 2947071 . + 0 Mb2692 aftc possible arabinofuranosyltransferase aftc Mb2692, -, len: 433 aa. Equivalent to Rv2673, len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 433 aa overlap). Possible conserved integral membrane protein, equivalent to MLC1351.25|ML1338 POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (440 aa), FASTA scores: opt: 2410,E(): 5.3e-143, (82.05% identity in 434 aa overlap); and showing some similarity with Q9CBX0|ML1504 PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (430 aa), FASTA scores: opt: 159, E(): 0.014, (24.4% identity in 340 aa overlap). Also similar to Q53873|SC6G4.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (411 aa), FASTA scores: opt: 383, E(): 1.4e-16,(29.6% identity in 422 aa overlap); and with weak similarity with P71061|YVFB HYPOTHETICAL PROTEIN from Bacillus subtilis (396 aa), FASTA scores: opt: 136, E(): 0.36, (24.35% identity in 279 aa overlap); and BAB60134|TVG1014811 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (695 aa), FASTA scores: opt: 133, E(): 0.85,(26.45% identity in 280 aa overlap). Shows also some similarity with O06557|Rv1159|MTCI65.26 HYPOTHETICAL 47.1 KDA PROTEIN from Mycobacterium tuberculosis (431 aa),FASTA scores: opt: 149, E(): 0.059, (22.45% identity in 410 aa overlap); and O53515|Rv2181|MTV021.14 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis (427 aa),FASTA scores: opt: 129, E(): 1, (24.8% identity in 367 aa overlap). Q7TY51 No cell wall and cell processes Rv2673 NC_002945.3 Mycobrowser_v2 CDS 2947240 2947650 . + 0 Mb2693 msrb probable peptide methionine sulfoxide reductase msrb (protein-methionine-r-oxide reductase) (peptide met(o) reductase) Mb2693, -, len: 136 aa. Equivalent to Rv2674, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Conserved hypothetical protein, highly similar to various proteins e.g. Q9X828|SC9B1.08 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (135 aa), FASTA scores: opt: 653,E(): 1.8e-37, (71.1% identity in 128 aa overlap); O26807|MTH711 TRANSCRIPTIONAL REGULATOR from Methanothermobacter thermautotrophicus (151 aa), FASTA scores: opt: 533, E(): 2.7e-29, (58.15% identity in 129 aa overlap); Q9C5C8|AT4G21860 HYPOTHETICAL 22.0 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (202 aa),FASTA scores: opt: 490, E(): 2.8e-26, (54.05% identity in 124 aa overlap); P39903|YEAA_ECOLI|B1778|Z2817|ECS2487 HYPOTHETICAL PROTEIN from Escherichia coli strains K12 and O157:H7 (137 aa), FASTA scores: opt: 426, E(): 4.4e-22,(46.8% identity in 126 aa overlap). Q7TY50 No intermediary metabolism and respiration Rv2674 NC_002945.3 Mycobrowser_v2 CDS 2948467 2949162 . - 0 Mb2695c conserved protein Mb2695c, -, len: 231 aa. Equivalent to Rv2676c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Conserved hypothetical protein, equivalent to Q9CCB2|ML1045 (alias Q50009|U1764Y but longer 66 aa) HYPOTHETICAL PROTEIN from Mycobacterium leprae (231 aa), FASTA scores: opt: 1401,E(): 8.7e-88, (87.45% identity in 231 aa overlap). Also highly similar to O69830|SC1B5.02 HYPOTHETICAL 28.1 KDA PROTEIN from Streptomyces coelicolor (243 aa), FASTA scores: opt: 915, E(): 7.7e-55, (61.25% identity in 222 aa overlap); and similar to others e.g. Q9RUB0|DR1481 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (289 aa), FASTA scores: opt: 327, E(): 6.1e-15, (31.8% identity in 176 aa overlap); Q97WP2|SSO2169 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (223 aa), FASTA scores: opt: 285, E(): 3.4e-12, (31.3% identity in 163 aa overlap); BAB59947|TVG0805714 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (223 aa), FASTA scores: opt: 206, E(): 7.7e-07,(25.0% identity in 176 aa overlap); etc. Q7TY48 No conserved hypotheticals Rv2676c NC_002945.3 Mycobrowser_v2 CDS 3005688 3008060 . - 0 Mb2756c recA RECA PROTEIN (RECOMBINASE A) [CONTAINS: ENDONUCLEASE PI-MTUI (MTU RECA INTEIN)]. Mb2756c, recA, len: 790 aa. Equivalent to Rv2737c,len: 790 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 790 aa overlap). recA, recombinase A (EC 3.1.-.-), (see citations below), equivalent to Q59560|RECA_MYCSM RECA PROTEIN from Mycobacterium smegmatis (349 aa), FASTA scores: opt: 1495, E(): 1.9e-79,(93.15% identity in 249 aa overlap); and P35901|RECA_MYCLE|ML0987 RECA PROTEIN from Mycobacterium leprae (711 aa), FASTA scores: opt: 1217, E(): 4.5e-63,(46.7% identity in 814 aa overlap). Also highly similar to many e.g. Q9REV6|RECA_AMYMD from Amycolatopsis mediterranei (Nocardia mediterranei) (348 aa), FASTA scores: opt: 1450, E(): 7.6e-77, (89.25% identity in 251 aa overlap); P42442|RECA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (376 aa), FASTA scores: opt: 1355, E(): 2.6e-71, (76.55% identity in 273 aa overlap); P41054|RECA_STRAM from Streptomyces ambofaciens (372 aa), FASTA scores: opt: 1347, E(): 7.6e-71, (82.1% identity in 246 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00321 recA signature, and PS00881 Protein splicing signature. BELONGS TO THE RECA FAMILY. THIS PROTEIN UNDERGOES A PROTEIN SELF SPLICING THAT INVOLVES A POST-TRANSLATIONAL EXCISION OF THE INTERVENING REGION (INTEIN) FOLLOWED BY PEPTIDE LIGATION. BELONGS TO THE HOMING ENDONUCLEASE FAMILY IN THE INTEIN SECTION. X2BLS4,P0A5U5 No NC_002945.3 Mycobrowser_v2 CDS 2949168 2950526 . - 0 Mb2696c hemY PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) Mb2696c, hemY, len: 452 aa. Equivalent to Rv2677c,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 452 aa overlap). Probable hemY,protoporphyrinogen oxidase (EC 1.3.3.4), equivalent to Q50008|PPOX_MYCLE|HEMY|ML1044 PROTOPORPHYRINOGEN OXIDASE from Mycobacterium leprae (451 aa), FASTA scores: opt: 2211, E(): 8.8e-118, (75.4% identity in 455 aa overlap). Also similar to others e.g. Q9RV99|DR1130 from Deinococcus radiodurans (462 aa), FASTA scores: opt: 523, E(): 2.7e-22, (29.8% identity in 453 aa overlap); O32434|PPOX_PROFR|HEMY from Propionibacterium freudenreichii shermanii (527 aa), FASTA scores: opt: 344,E(): 4e-12, (32.1% identity in 495 aa overlap); P32397|PPOX_BACSU|HEMY|HEMG from Bacillus subtilis (470 aa), FASTA scores: opt: 305, E(): 5.9e-10, (26.8% identity in 463 aa overlap); etc. BELONGS TO THE PROTOPORPHYRINOGEN OXIDASE FAMILY. COFACTOR: CONTAINS ONE FAD PER HOMODIMER. X2BLI7,P0A5A8 No NC_002945.3 Mycobrowser_v2 CDS 2950523 2951596 . - 0 Mb2697c hemE probable uroporphyrinogen decarboxylase heme (uroporphyrinogen iii decarboxylase) (uro-d) (upd) Mb2697c, hemE, len: 357 aa. Equivalent to Rv2678c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 357 aa overlap). Probable hemE,uroporphyrinogen decarboxylase (EC 4.1.1.37), equivalent to P46809|DCUP_MYCLE|HEME|ML1043 UROPORPHYRINOGEN DECARBOXYLASE from Mycobacterium leprae (357 aa), FASTA scores: opt: 2017, E(): 8.2e-111, (83.75% identity in 357 aa overlap). Also highly similar to many e.g. O69861|DCUP_STRCO|HEME|SC1C3.19 from Streptomyces coelicolor (355 aa), FASTA scores: opt: 1165, E(): 5.6e-61, (58.15% identity in 349 aa overlap); P32395|DCUP_BACSU|HEME from Bacillus subtilis (353 aa),FASTA scores: opt: 859, E(): 4.5e-43, (44.1% identity in 356 aa overlap); Q9RV96|DCUP_DEIRA|HEME|DR1133 from Deinococcus radiodurans (344 aa), FASTA scores: opt: 850,E(): 1.5e-42, (43.0% identity in 349 aa overlap); etc. Equivalent to AAK47067 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but shorter 15 aa. Contains PS00907 Uroporphyrinogen decarboxylase signature 2. BELONGS TO THE UROPORPHYRINOGEN DECARBOXYLASE FAMILY. X2BLZ0,Q7TY47 No NC_002945.3 Mycobrowser_v2 CDS 2951649 2952479 . + 0 Mb2698 echA15 PROBABLE ENOYL-COA HYDRATASE ECHA15 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb2698, -, len: 276 aa. Equivalent to Rv2679, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Probable echA15,enoyl-CoA hydratase (EC 4.2.1.17), similar to P53526|ECHC_MYCLE|ECHA12|ML1241|MLCB1610.01|B1170_C2_224 PROBABLE ENOYL-COA HYDRATASE from Mycobacterium leprae (294 aa), FASTA scores: opt: 368, E(): 2.5e-16, (32.15% identity in 277 aa overlap). Also highly similar to Q9RXX1|DR0184 from Deinococcus radiodurans (273 aa), FASTA scores: opt: 993, E(): 2.2e-56, (58.15% identity in 263 aa overlap); and similar to many e.g. Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa), FASTA scores: opt: 396, E(): 3.8e-18, (34.9% identity in 258 aa overlap); O29299|AF0963|FAD-3 from Archaeoglobus fulgidus (259 aa),FASTA scores: opt: 363, E(): 4.7e-16, (30.4% identity in 250 aa overlap); P77467|PAAG_ECOLI|B1394 from Escherichia coli strain W (262 aa), FASTA scores: opt: 357, E(): 1.1e-15, (31.75% identity in 252 aa overlap); etc. Also similar to O53163|ECHC_MYCTU|ECHA12|FADB2|Rv1472|MT1518|MTV007.19 ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (285 aa), FASTA scores: opt: 355, E(): 1.6e-15, (31.3% identity in 265 aa overlap); and O06542|ECHA10|Rv1142c|MTCI65.09c|Z95584 ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (268 aa). Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Q7TY46 No lipid metabolism Rv2679 NC_002945.3 Mycobrowser_v2 CDS 2952741 2953373 . + 0 Mb2699 conserved protein Mb2699, -, len: 210 aa. Equivalent to Rv2680, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Conserved hypothetical protein, equivalent to Q50005|ML1041|U1764V HYPOTHETICAL PROTEIN from Mycobacterium leprae (196 aa),FASTA scores: opt: 1136, E(): 9.7e-66, (83.95% identity in 193 aa overlap). Also similar to O69860|SC1C3.18c HYPOTHETICAL 24.7 KDA PROTEIN from Streptomyces coelicolor (238 aa), FASTA scores: opt: 516, E(): 5.7e-26, (45.5% identity in 189 aa overlap); and similar in part to Q9I6V4|PA0178 PROBABLE TWO-COMPONENT SENSOR from Pseudomonas aeruginosa (639 aa), FASTA scores: opt: 120,E(): 3.1, (33.05% identity in 115 aa overlap); and a few other proteins. Equivalent to AAK47069 from Mycobacterium tuberculosis strain CDC1551 (178 aa) but longer 32 aa; and N-terminus highly similar to N-terminus of AAK48352|MT3984 HYPOTHETICAL 4.2 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (38 aa), FASTA scores: opt: 102, E(): 3.6, (62.05% identity in 29 aa overlap). Q7TY45 No conserved hypotheticals Rv2680 NC_002945.3 Mycobrowser_v2 CDS 2953375 2954691 . + 0 Mb2700 CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN Mb2700, -, len: 438 aa. Equivalent to Rv2681, len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 438 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q50004|ML1040|U1764U HYPOTHETICAL PROTEIN from Mycobacterium leprae (429 aa),FASTA scores: opt: 2146, E(): 1.1e-119, (77.4% identity in 416 aa overlap). Also highly similar to O69858|SC1C3.16c HYPOTHETICAL 42.5 KDA PROTEIN from Streptomyces coelicolor (394 aa), FASTA scores: opt: 1336, E(): 9e-72, (51.6% identity in 405 aa overlap); and with some similarity to RIBONUCLEASES D e.g. Q983F2|MLL8354 from Rhizobium loti (Mesorhizobium loti) (383 aa), FASTA scores: opt: 379,E(): 3.9e-15, (31.6% identity in 323 aa overlap); Q9A7L8|CC1704 from Caulobacter crescentus (389 aa), FASTA scores: opt: 370, E(): 1.3e-14, (31.45% identity in 318 aa overlap); CAC45770 from Rhizobium meliloti (Sinorhizobium meliloti) (383 aa), FASTA scores: opt: 331, E(): 2.7e-12,(27.75% identity in 357 aa overlap); etc. Q7TY44 No conserved hypotheticals Rv2681 NC_002945.3 Mycobrowser_v2 CDS 2956748 2957245 . + 0 Mb2702 conserved protein Mb2702, -, len: 165 aa. Equivalent to Rv2683, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 165 aa overlap). Conserved hypothetical protein, equivalent, but shorter 19 aa, to Q49999|ML1037|U1764Q HYPOTHETICAL PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: opt: 750,E(): 1.2e-41, (73.8% identity in 164 aa overlap). Shows some similarity with other HYPOTHETICAL PROTEINS e.g. Q988S9|MLL6611 from Rhizobium loti (Mesorhizobium loti) (232 aa), FASTA scores: opt: 128, E(): 0.25, (25.5% identity in 149 aa overlap); Q9YFL5|APE0233 from Aeropyrum pernix (340 aa), FASTA scores: opt: 123, E(): 0.73, (29.1% identity in 141 aa overlap); BAB60477|TVG1377730 from Thermoplasma volcanium (174 aa), FASTA scores: opt: 118,E(): 0.86, (28.8% identity in 59 aa overlap); etc. Q7TY43 No conserved hypotheticals Rv2683 NC_002945.3 Mycobrowser_v2 CDS 2957250 2958539 . + 0 Mb2703 arsA PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSA Mb2703, arsA, len: 429 aa. Equivalent to Rv2684,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Probable arsA,arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA PROBABLE INTEGRAL MEMBRANE PROTEIN (antigen 45, a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa), FASTA scores: opt: 2067, E(): 9.9e-118, (74.05% identity in 428 aa overlap); and upstream orf O07187|YQ85_MYCTU|ARSB|Rv2685|MT2759|MTCY05A6.06 PROBABLE INTEGRAL MEMBRANE 45.2 KDA PROTEIN ARSB from Mycobacterium tuberculosis (428 aa), FASTA scores: opt: 2148, E(): 1.3e-122, (76.58% identity in 427 aa overlap). Also highly similar to other proteins e.g. Q9UY19|PAB1107 TRANSPORT PROTEIN from Pyrococcus abyssi (425 aa), FASTA scores: opt: 1109, E(): 8.3e-60, (41.45% identity in 427 aa overlap); O59575|PH1912 HYPOTHETICAL 46.0 KDA PROTEIN from Pyrococcus horikoshii (424 aa), FASTA scores: opt: 1101,E(): 2.5e-59, (41.95% identity in 429 aa overlap); Q9KDI2|BH1231 HYPOTHETICAL 46.0 KDA PROTEIN from Bacillus halodurans (428 aa), FASTA scores: opt: 1018, E(): 2.7e-54, (38.9% identity in 427 aa overlap); etc. BELONGS TO THE NADC/P/PHO87 FAMILY OF TRANSPORTERS, P SUBFAMILY (ARS FAMILY). X2BL67,P0A607 No cell wall and cell processes Rv2684 NC_002945.3 Mycobrowser_v2 CDS 2958619 2959905 . + 0 Mb2704 arsB1 PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSB1 Mb2704, arsB1, len: 428 aa. Equivalent to Rv2685,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 428 aa overlap). Probable arsB1,arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA PROBABLE INTEGRAL MEMBRANE PROTEIN (antigen 45, a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa), FASTA scores: opt: 2048, E(): 7.3e-120, (74.25% identity in 427 aa overlap); and downstream ORF O07186|YQ84_MYCTU|ARSA|Rv2684|MT2758|MTCY05A6.05 PROBABLE INTEGRAL MEMBRANE PROTEIN ARSA from Mycobacterium tuberculosis (429 aa), FASTA scores: opt: 2154, E(): 1.9e-126, (76.8% identity in 427 aa overlap). Also highly similar to other proteins e.g. O59575|PH1912 HYPOTHETICAL 46.0 KDA PROTEIN from Pyrococcus horikoshii (424 aa),FASTA scores: opt: 1075, E(): 1.9e-59, (43.55% identity in 427 aa overlap); Q9UY19|PAB1107 TRANSPORT PROTEIN from Pyrococcus abyssi (425 aa), FASTA scores: opt: 1062, E(): 1.3e-58, (41.8% identity in 428 aa overlap); Q9KDI2|BH1231 HYPOTHETICAL 46.0 KDA PROTEIN from Bacillus halodurans (428 aa), FASTA scores: opt: 993, E(): 2.4e-54, (39.55% identity in 430 aa overlap); etc. BELONGS TO THE NADC/P/PHO87 FAMILY OF TRANSPORTERS, P SUBFAMILY. Note that previously known as arsB. Q7TY42 No NC_002945.3 Mycobrowser_v2 CDS 3008255 3008428 . + 0 Mb2757 CONSERVED HYPOTHETICAL CYSTEINE RICH PROTEIN (FRAGMENT) Mb2757, -, len: 57 aa. Equivalent to Rv2737A, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Conserved hypothetical cys-rich protein (possibly gene fragment), similar to central part of AJ243803_1|glgA from Streptomyces coelicolor glgA (181 aa), FASTA scores: opt: 210, E(): 6.1e-09, (59.25% identity in 54 aa overlap). Q7TY03 No conserved hypotheticals Rv2737A NC_002945.3 Mycobrowser_v2 CDS 2959916 2960674 . - 0 Mb2705c antibiotic-transport integral membrane leucine and alanine and valine rich protein abc transporter Mb2705c, -, len: 252 aa. Equivalent to Rv2686c,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable antibiotic-transport integral membrane leu-, ala-,val-rich protein ABC transporter (see citation below). The region from aa ~115 to 160 is highly similar to N-terminus of Q49998|U1764P HYPOTHETICAL PROTEIN from Mycobacterium leprae (53 aa), FASTA scores: opt: 151, E(): 0.011,(58.15% identity in 43 aa overlap). Shows some similarity with membrane proteins e.g. AAK75541|SP1447 MEMBRANE PROTEIN from Streptococcus pneumoniae (298 aa), FASTA scores: opt: 139, E(): 0.21, (29.65% identity in 135 aa overlap); Q9K4C9|2SC6G5.26c PUTATIVE ABC TRANSPORTER INTEGRAL MEMBRANE SUBUNIT from Streptomyces coelicolor (249 aa), FASTA scores: opt: 138, E(): 0.21, (26.9% identity in 253 aa overlap); Q53627|MTRB MEMBRANE PROTEIN INVOLVED IN MITHRAMYCIN RESISTANCE from Streptomyces argillaceus (233 aa), FASTA scores: opt: 136, E(): 0.27,(26.7% identity in 191 aa overlap); etc. Q7TY41 No cell wall and cell processes Rv2686c NC_002945.3 Mycobrowser_v2 CDS 2960671 2961384 . - 0 Mb2706c antibiotic-transport integral membrane leucine and valine rich protein abc transporter Mb2706c, -, len: 237 aa. Equivalent to Rv2687c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Probable antibiotic-transport integral membrane leu-, val-rich protein ABC transporter (see citation below), showing some similarity with two other hypothetical proteins,BAB59668|TVG0517148 from Thermoplasma volcanium (241 aa),FASTA scores: opt: 136, E(): 0.32, (23.1% identity in 208 aa overlap); and Q97U55|SSO3168 from Sulfolobus solfataricus (249 aa), FASTA scores: opt: 136, E(): 0.33,(25.15% identity in 195 aa overlap). Has some hydrophobic stretches and contains bacterial regulatory proteins, araC family signature (PS00041). Q7TY40 No cell wall and cell processes Rv2687c NC_002945.3 Mycobrowser_v2 CDS 2961381 2962286 . - 0 Mb2707c antibiotic-transport atp-binding protein abc transporter Mb2707c, -, len: 301 aa. Equivalent to Rv2688c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 301 aa overlap). Probable antibiotic-transport ATP-binding protein ABC transporter (see citation below), highly similar to AAK47077|MT2762 ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551 (317 aa), FASTA scores: opt: 1714, E(): 5.1e-93, (95.6% identity in 274 aa overlap). Also highly similar to other ATP-BINDING PROTEINS ABC TRANSPORTER e.g. Q9K639|BH3893 from Bacillus halodurans (282 aa), FASTA scores: opt: 644, E(): 1.4e-30, (38.% identity in 285 aa overlap); O58550|PH0820 from Pyrococcus horikoshii (312 aa), FASTA scores: opt: 574, E(): 1.8e-26,(39.1% identity in 307 aa overlap); Q9WYM0|TM0389 from Thermotoga maritima (301 aa), FASTA scores: opt: 536, E(): 2.9e-24, (36.1% identity in 291 aa overlap); etc. Has ATP/GTP-binding site motif A (P-loop) at N-terminus (PS00017). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TY39 No cell wall and cell processes Rv2688c NC_002945.3 Mycobrowser_v2 CDS 2962481 2963698 . - 0 Mb2708c conserved alanine and valine and glycine rich protein Mb2708c, -, len: 405 aa. Equivalent to Rv2689c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Conserved hypothetical ala-, val-, gly-rich protein, similar to O54099|SC10A5.06 HYPOTHETICAL 49.5 KDA PROTEIN from Streptomyces coelicolor (458 aa), FASTA scores: opt: 455,E(): 2.7e-20, (38.35% identity in 417 aa overlap); and shows weak similarity in part with several methyltransferases (EC 2.1.1.-) e.g. Q9X0H9|TM1094 PUTATIVE RNA METHYLTRANSFERASE from Thermotoga maritima (439 aa), FASTA scores: opt: 306, E(): 3e-11, (25.9% identity in 436 aa overlap); AK79403|CAC1435 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES from Clostridium acetobutylicum (456 aa), FASTA scores: opt: 294, E(): 1.6e-10, (23.4% identity in 449 aa overlap); Q9A8M7|CC1326 RNA METHYLTRANSFERASE from Caulobacter crescentus (415 aa), FASTA scores: opt: 247, E(): 1.1e-07,(28.4% identity in 433 aa overlap); etc. Equivalent to AAK47078 from Mycobacterium tuberculosis strain CDC1551 (434 aa) but shorter 29 aa. Other less probable starts possible. Q7TY38 No conserved hypotheticals Rv2689c NC_002945.3 Mycobrowser_v2 CDS 2963854 2965845 . - 0 Mb2709c PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND VALINE AND LEUCINE RICH PROTEIN Mb2709c, -, len: 663 aa. Equivalent to Rv2690c,len: 657 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 657 aa overlap). Probable conserved integral membrane ala-, val-, leu-rich protein, highly similar to others e.g. O54098|SC10A5.05 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (691 aa), FASTA scores: opt: 2007, E(): 1.6e-116, (62.35% identity in 669 aa overlap); O69917|SC3C8.04c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (644 aa), FASTA scores: opt: 923, E(): 1.7e-49, (35.3% identity in 669 aa overlap); AAK78253|CAC0272 AMINO ACID TRANSPORTER from Clostridium acetobutylicum (620 aa), FASTA scores: opt: 674, E(): 4.1e-34, (36.55% identity in 640 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657 aa). Q7TY37 No cell wall and cell processes Rv2690c NC_002945.3 Mycobrowser_v2 CDS 2980906 2981964 . - 0 Mb2731c HYPOTHETICAL PROTEIN Mb2731c, -, len: 352 aa. Equivalent to Rv2712c,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Hypothetical unknown ala-, leu-rich protein. Q7TY19 No conserved hypotheticals Rv2712c NC_002945.3 Mycobrowser_v2 CDS 2965980 2966663 . + 0 Mb2710 ceoB TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOB Mb2710, ceoB, len: 227 aa. Equivalent to Rv2691,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 227 aa overlap). ceoB (alternate gene name: trkA), TRK system potassium uptake protein (see citation below), highly similar to others e.g. Q53949|TRKA_STRCO|SC2E9.17c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 781, E(): 5.8e-42, (53.2% identity in 220 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 287, E(): 5.3e-11, (27.0% identity in 211 aa overlap); O54141|SC2E9.16c from Streptomyces coelicolor (226 aa), FASTA scores: opt: 269, E(): 7.3e-10, (29.9% identity in 214 aa overlap); etc. Also similar to upstream orf O07194|CEOC|TRKA_MYCTU|TRKA|TRKB|Rv2692|MT2766|MTCY05A6.13 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 259, E(): 3e-09,(26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY. Q7TY36 No cell wall and cell processes Rv2691 NC_002945.3 Mycobrowser_v2 CDS 2966660 2967322 . + 0 Mb2711 ceoC TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOC Mb2711, ceoC, len: 220 aa. Equivalent to Rv2692,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 220 aa overlap). ceoC (alternate gene names: trkA and trkB), TRK system potassium uptake protein (see citation below), highly similar to others e.g. O54141|SC2E9.16c from Streptomyces coelicolor (226 aa),FASTA scores: opt: 870, E(): 9.4e-48, (58.8% identity in 216 aa overlap); Q58505|TRKA_METJA|MJ1105 from Methanococcus jannaschii (218 aa), FASTA scores: opt: 361,E(): 9.7e-16, (29.8% identity in 218 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 326, E(): 1.5e-13, (30.1% identity in 216 aa overlap); etc. Also similar to downstream orf O07193|CEOB|TRKA|Rv2691|MTCY05A6.12 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (227 aa),FASTA scores: opt: 259, E(): 2.6e-09, (26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY. Q7TY35 No cell wall and cell processes Rv2692 NC_002945.3 Mycobrowser_v2 CDS 2967333 2968004 . - 0 Mb2712c PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND LEUCINE RICH PROTEIN Mb2712c, -, len: 223 aa. Equivalent to Rv2693c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Probable conserved integral membrane ala-, leu-rich protein, showing some similarity to O54140|SC2E9.15 HYPOTHETICAL 29.6 KDA PROTEIN from Streptomyces coelicolor (272 aa), FASTA scores: opt: 212, E(): 4.3e-06, (23.5% identity in 247 aa overlap). Q7TY34 No cell wall and cell processes Rv2693c NC_002945.3 Mycobrowser_v2 CDS 2968035 2968403 . - 0 Mb2713c conserved protein Mb2713c, -, len: 122 aa. Equivalent to Rv2694c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 122 aa overlap). Conserved hypothetical protein, highly similar in part to SC2E9.14 HYPOTHETICAL 16.9 KDA PROTEIN from Streptomyces coelicolor (154 aa),FASTA scores: opt: 299, E(): 1.9e-13, (41.05% identity in 117 aa overlap. Equivalent to AAK47083 from Mycobacterium tuberculosis strain CDC1551 (157 aa) but shorter 35 aa. Q7TY33 No conserved hypotheticals Rv2694c NC_002945.3 Mycobrowser_v2 CDS 2968552 2969259 . + 0 Mb2714 CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN Mb2714, -, len: 235 aa. Equivalent to Rv2695, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 235 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q49994|ML1030|U1764L HYPOTHETICAL PROTEIN from Mycobacterium leprae (232 aa), FASTA scores: opt: 1166,E(): 6.3e-63, (76.95% identity in 230 aa overlap). Also shows some similarity with other hypothetical proteins e.g. Q986S2|MLR7232 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (277 aa), FASTA scores: opt: 150, E(): 0.059, (33.55% identity in 173 aa overlap); CAC47772|SMC03810 HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (269 aa), FASTA scores: opt: 143, E(): 0.15, (28.05% identity in 228 aa overlap); Q9A5N6|CC2411 3-OXOADIPATE ENOL-LACTONE HYDROLASE/4-CARBOXYMUCONOLACTONE DECARBOXYLASE from Caulobacter crescentus (393 aa), FASTA scores: opt: 138,E(): 0.41, (26.45% identity in 238 aa overlap); etc. Q7TY32 No conserved hypotheticals Rv2695 NC_002945.3 Mycobrowser_v2 CDS 2969465 2970244 . - 0 Mb2715c conserved alanine and glycine and valine rich protein Mb2715c, -, len: 259 aa. Equivalent to Rv2696c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 259 aa overlap). Conserved hypothetical ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K HYPOTHETICAL PROTEIN from Mycobacterium leprae (273 aa), FASTA scores: opt: 1174,E(): 2.1e-63, (70.6% identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06, (28.25% identity in 255 aa overlap); and showing weak similarity with other proteins. Q7TY31 No conserved hypotheticals Rv2696c NC_002945.3 Mycobrowser_v2 CDS 3008442 3008648 . - 0 Mb2758c CONSERVED HYPOTHETICAL PROTEIN Mb2758c, -, len: 68 aa. Equivalent to Rv2738c, len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Conserved hypothetical protein, equivalent to Q9CCC1|ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 397,E(): 3.7e-22, (83.6% identity in 67 aa overlap). Also highly similar to O50484|SC4H8.05 HYPOTHETICAL 7.5 KDA PROTEIN from Streptomyces coelicolor (64 aa), FASTA scores: opt: 185, E(): 5.9e-07, (39.7% identity in 63 aa overlap). Second part of the protein is highly similar to C-terminus of upstream ORF O33285|Rv2742c|MTV002.07c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 200, E(): 1.7e-07, (78.4% identity in 37 aa overlap). Q7TY02 No conserved hypotheticals Rv2738c NC_002945.3 Mycobrowser_v2 CDS 2970319 2970783 . - 0 Mb2716c dut probable deoxyuridine 5'-triphosphate nucleotidohydrolase dut (dutpase) (dutp pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dutp diphosphatase) (deoxyuridine-triphosphatase) Mb2716c, dut, len: 154 aa. Equivalent to Rv2697c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Probable dut,deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23), equivalent to Q49992|DUT_MYCLE|ML1028 DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE from Mycobacterium leprae (154 aa), FASTA scores: opt: 928,E(): 2.1e-51, (90.25% identity in 154 aa overlap). Also highly similar to others e.g. O54134|DUT_STRCO|SC2E9.09 from Streptomyces coelicolor (183 aa), FASTA scores: opt: 534, E(): 1.2e-26, (56.1% identity in 148 aa overlap); O66592|DUT_AQUAE|AQ_220 from Aquifex aeolicus (150 aa),FASTA scores: opt: 398, E(): 3.3e-18, (48.05% identity in 152 aa overlap); Q9X3X5|DUT_ZYMMO from Zymomonas mobilis (146 aa), FASTA scores: opt: 396, E(): 4.4e-18, (49.0% identity in 147 aa overlap); etc. BELONGS TO THE DUTPASE FAMILY. X2BLL2,P0A553 No NC_002945.3 Mycobrowser_v2 CDS 2970809 2971294 . + 0 Mb2717 PROBABLE CONSERVED ALANINE RICH TRANSMEMBRANE PROTEIN Mb2717, -, len: 161 aa. Equivalent to Rv2698, len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I POSSIBLE MEMBRANE PROTEIN from Mycobacterium leprae (157 aa), FASTA scores: opt: 886,E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also similar to O54132|SC2E9.07c HYPOTHETICAL 16.5 KDA PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 230, E(): 7.1e-08, (35.7% identity in 154 aa overlap). Q7TY30 No cell wall and cell processes Rv2698 NC_002945.3 Mycobrowser_v2 CDS 2971299 2971601 . - 0 Mb2718c CONSERVED HYPOTHETICAL PROTEIN Mb2718c, -, len: 100 aa. Equivalent to Rv2699c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Conserved hypothetical protein, very equivalent to Q49990|ML1026|U1764J HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 632,E(): 7.7e-36, (96.0% identity in 100 aa overlap). Also highly similar to O54130|SC2E9.05 HYPOTHETICAL 11.0 KDA PROTEIN from Streptomyces coelicolor (98 aa), FASTA scores: opt: 465, E(): 1.1e-24, (71.45% identity in 98 aa overlap). Q7TY29 No conserved hypotheticals Rv2699c NC_002945.3 Mycobrowser_v2 CDS 2971839 2972489 . + 0 Mb2719 possible conserved secreted alanine rich protein Mb2719, -, len: 216 aa. Equivalent to Rv2700, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Possible secreted ala-rich protein, equivalent to Q4998|ML1025|U1764H POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (216 aa), FASTA scores: opt: 1198, E(): 1.2e-65, (82.4% identity in 216 aa overlap). Also showing some similarity with Q9AK75|2SCD60.08c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (204 aa), FASTA scores: opt: 193,E(): 8.9e-05, (31.25% identity in 192 aa overlap). Q7TY28 No cell wall and cell processes Rv2700 NC_002945.3 Mycobrowser_v2 CDS 2972499 2973371 . - 0 Mb2720c suhB inositol-1-monophosphatase suhb Mb2720c, suhB, len: 290 aa. Equivalent to Rv2701c,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 290 aa overlap). Possible suhB,extragenic suppressor protein, equivalent to P46813|SUHB_MYCLE|SUHB|SSYA|ML1024 EXTRAGENIC SUPPRESSOR PROTEIN from Mycobacterium leprae (291 aa), FASTA scores: opt: 1424, E(): 4.9e-78, (77.55% identity in 294 aa overlap). Similar (except at N-terminus) to others e.g. O54128|SUHB from Streptomyces coelicolor (209 aa), FASTA scores: opt: 560, E(): 1.7e-26, (46.95% identity in 213 aa overlap); Q9CNV8|SUHB|PM0315 from Pasteurella multocida (267 aa), FASTA scores: opt: 479, E(): 1.5e-21, (39.3% identity in 234 aa overlap); P44333|SUHB_HAEIN|HI0937 from Haemophilus influenzae (267 aa), FASTA scores: opt: 438,E(): 4.1e-19, (34.7% identity in 248 aa overlap); P22783|SUHB_ECOLI|SSYA|B2533 from Escherichia coli strain K12 (267 aa), FASTA scores: opt: 419, E(): 5.7e-18,(34.45% identity in 267 aa overlap); etc. And also similar to putative myo-inositol-1(or 4)-monophosphatases e.g. Q9S1M1|SPCA from Streptoverticillium netropsis (Streptoverticillium flavopersicus) (266 aa), FASTA scores: opt: 556, E(): 3.6e-26, (45.4% identity in 240 aa overlap); Q9S3X5|SPCA from Streptomyces spectabilis (264 aa), FASTA scores: opt: 502, E(): 6.1e-23, (46.05% identity in 265 aa overlap); CAC47357 from Rhizobium meliloti (Sinorhizobium meliloti) (266 aa), FASTA scores: opt: 452, E(): 6e-20, (38.5% identity in 244 aa overlap); etc. Equivalent to AAK47090 from Mycobacterium tuberculosis strain CDC1551 (277 aa) but longer 13 aa. Contains PS00630 Inositol monophosphatase family signatures 1 and 2 (PS00629 and PS00630). BELONGS TO THE INOSITOL MONOPHOSPHATASE FAMILY. X2BLB6,P65166 No NC_002945.3 Mycobrowser_v2 CDS 2973494 2974291 . + 0 Mb2721 ppgK POLYPHOSPHATE GLUCOKINASE PPGK (POLYPHOSPHATE-GLUCOSE PHOSPHOTRANSFERASE) Mb2721, ppgK, len: 265 aa. Equivalent to Rv2702,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 265 aa overlap). ppgK, polyphosphate glucokinase (EC 2.7.1.2) (see citation below), equivalent,but shorter 60 aa, to Q49988|PPGK_MYCLE|ML1023|U1764FG POLYPHOSPHATE GLUCOKINASE from Mycobacterium leprae (324 aa), FASTA scores: opt: 1411, E(): 5.6e-80, (82.8% identity in 262 aa overlap). Also highly similar (or just similar) to others e.g. Q9ADE8|PPGK from Streptomyces coelicolor (246 aa), FASTA scores: opt: 912, E(): 3e-49,(57.3% identity in 239 aa overlap); Q9AGV8|PPGK from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (277 aa), FASTA scores: opt: 890, E(): 7.5e-48, (57.75% identity in 239 aa overlap); P40184|GLK_STRCO|SC6E10.20c from Streptomyces coelicolor (317 aa), FASTA scores: opt: 233, E(): 3.2e-07, (31.3% identity in 163 aa overlap); etc. Q7TY27 No intermediary metabolism and respiration Rv2702 NC_002945.3 Mycobrowser_v2 CDS 3058130 3058711 . - 0 Mb2815c POSSIBLE RESOLVASE Mb2815c, -, len: 193 aa. Equivalent to Rv2792c,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 193 aa overlap). Possible IS1602 resolvase, highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c POSSIBLE RESOLVASE (202 aa), FASTA scores: opt: 1040, E(): 1.9e-62,(85.05% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site and possible helix-turn-helix motif at aa 1-2 (Score 1687, +4.93 SD). Q7TXV2 No insertion seqs and phages Rv2792c NC_002945.3 Mycobrowser_v2 CDS 2982077 2983483 . + 0 Mb2732 sthA PROBABLE SOLUBLE PYRIDINE NUCLEOTIDE TRANSHYDROGENASE STHA (STH) (NAD(P)(+) TRANSHYDROGENASE [B-SPECIFIC]) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE) Mb2732, sthA, len: 468 aa. Equivalent to Rv2713,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable sthA,soluble pyridine nucleotide transhydrogenase (EC 1.6.1.1),highly similar to others e.g. Q983E2|MLR8366 from Rhizobium loti (Mesorhizobium loti) (481 aa), FASTA scores: opt: 1447, E(): 4.1e-78, (49.55% identity in 460 aa overlap); P27306|STHA_ECOLI|STH|UDHA|B3962 from Escherichia coli strain K12 (465 aa), FASTA scores: opt: 1267, E(): 1.7e-67, (43.05% identity in 462 aa overlap); O05139|STHA_PSEFL|STH from Pseudomonas fluorescens (463 aa), FASTA scores: opt: 1257, E(): 6.6e-67, (43.8% identity in 461 aa overlap); etc. Also highly similar to CAC46308|SMC00300 PUTATIVE OXIDOREDUCTASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (467 aa),FASTA scores: opt: 1466, E(): 3e-79, (49.55% identity in 462 aa overlap). Shows some similarity to MTCY359.04, E(): 3.1e-08; MTCY210.05, E(): 3.4e-08. Contains ATP/GTP-binding site motif A (P-loop; PS00017). BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD (BY SIMILARITY). X2BM22,P66007 No intermediary metabolism and respiration Rv2713 NC_002945.3 Mycobrowser_v2 CDS 2974471 2976057 . + 0 Mb2722 sigA RNA POLYMERASE SIGMA FACTOR SIGA (SIGMA-A) Mb2722, sigA, len: 528 aa. Equivalent to Rv2703,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 528 aa overlap). sigA (formerly named mysA, and also known as rpoV or rpoD), RNA polymerase sigma factor (see citations below), equivalent (but shorter 55 aa) to Q9S5K3|RPOT (alias Q59532) RNA POLYMERASE SIGMA FACTOR from Mycobacterium leprae (576 aa), FASTA scores: opt: 2638, E(): 8.6e-115, (80.35% identity in 535 aa overlap). Also similar to others e.g. Q59552|MYSA from Mycobacterium smegmatis (466 aa), FASTA scores: opt: 2259, E(): 2.3e-97, (76.5% identity in 528 aa overlap); Q45302|SIGA from Corynebacterium glutamicum (Brevibacterium flavum) (497 aa), FASTA scores: opt: 1972,E(): 4.3e-84, (67.35% identity in 505 aa overlap); Q59813|HRDB from Streptomyces aureofaciens (525 aa), FASTA scores: opt: 1654, E(): 2.1e-69, (67.5% identity in 468 aa overlap); etc. Contains sigma-70 family signatures 1 and 2 (PS00715 and PS00716). BELONGS TO THE SIGMA-70 FACTOR FAMILY. X2BM11,P0A603 No information pathways Rv2703 NC_002945.3 Mycobrowser_v2 CDS 2978475 2978921 . + 0 Mb2728 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2728, -, len: 148 aa. Equivalent to Rv2709, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 148 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CCB4|ML1015 (alias Q49983|U1764B but extended in N-terminus) POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (139 aa), FASTA scores: opt: 578, E(): 5.5e-31, (70.75% identity in 123 aa overlap). Shows also similarity with Q9RJ48|SCI8.05 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (159 aa), FASTA scores: opt: 119,E(): 0.57, (31.95% identity in 119 aa overlap). Q7TY21 No cell wall and cell processes Rv2709 NC_002945.3 Mycobrowser_v2 CDS 2976094 2976522 . + 0 Mb2723 conserved protein Mb2723, -, len: 142 aa. Equivalent to Rv2704, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, highly similar (but shorter 25 aa) to Q9RYB7|DR0033 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (157 aa), FASTA scores: opt: 381,E(): 1.5e-17, (54.85% identity in 124 aa overlap); and highly similar to various proteins e.g. CAC47758|SMC03796 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (126 aa), FASTA scores: opt: 302,E(): 1.4e-12, (46.6% identity in 126 aa overlap); Q98E55|MLL4402 from Rhizobium loti (Mesorhizobium loti) (130 aa), FASTA scores: opt: 252, E(): 2.1e-09, (40.15% identity in 127 aa overlap); Q9K3V5|SCD10.21 PUTATIVE ACETYLTRANSFERASE from Streptomyces coelicolor (291 aa),FASTA scores: opt: 247, E(): 8.7e-09, (41.3% identity in 138 aa overlap) (homology only in N-terminal region); etc. Q7TY26 No conserved hypotheticals Rv2704 NC_002945.3 Mycobrowser_v2 CDS 2976450 2976839 . - 0 Mb2724c CONSERVED HYPOTHETICAL PROTEIN Mb2724c, -, len: 129 aa. Equivalent to Rv2705c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to others e.g. Q9RXR5|DR0242 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (112 aa), FASTA scores: opt: 259, E(): 9.4e-10, (40.5% identity in 116 aa overlap); CAC45122|SMC02246 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (115 aa),FASTA scores: opt: 208, E(): 1.6e-06, (38.3% identity in 107 aa overlap); Q98B88|MLL5682 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (116 aa), FASTA scores: opt: 173, E(): 0.00026, (34.95% identity in 103 aa overlap); etc. Q7TY25 No conserved hypotheticals Rv2705c NC_002945.3 Mycobrowser_v2 CDS 2977209 2978183 . + 0 Mb2726 PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN Mb2726, -, len: 324 aa. Equivalent to Rv2707, len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Probable conserved transmembrane ala-, leu-rich protein, equivalent to Q49985|ML1017|U1764D POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (330 aa), FASTA scores: opt: 1617, E(): 2.5e-91, (75.4% identity in 325 aa overlap). Also similar to other membrane proteins e.g. Q9ADF6|SCBAC1A6.31 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (344 aa), FASTA scores: opt: 593,E(): 5.9e-29, (36.2% identity in 268 aa overlap); Q99SZ8|SA1699 HYPOTHETICAL PROTEIN (similar to transporter) from Staphylococcus aureus subsp. aureus N315 (405 aa), FASTA scores: opt: 318, E(): 3.7e-12, (27.9% identity in 265 aa overlap); O34437|YFKH HYPOTHETICAL PROTEIN (similar to transporter) from Bacillus subtilis (275 aa), FASTA scores: opt: 309, E(): 9.7e-12, (29.3% identity in 263 aa overlap); etc. Q7TY23 No conserved hypotheticals Rv2707 NC_002945.3 Mycobrowser_v2 CDS 2978184 2978432 . - 0 Mb2727c CONSERVED HYPOTHETICAL PROTEIN Mb2727c, -, len: 82 aa. Equivalent to Rv2708c, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 82 aa overlap). Conserved hypothetical protein, equivalent (but shorter 25 aa) to Q49984|ML1016|U1764C HYPOTHETICAL PROTEIN from Mycobacterium leprae (107 aa), FASTA scores: opt: 492,E(): 7.3e-27, (87.8% identity in 82 aa overlap). Also highly similar to Q9L1U7|SCE59.06c HYPOTHETICAL 10.4 KDA PROTEIN from Streptomyces coelicolor (97 aa), FASTA scores: opt: 200, E(): 4.4e-07, (51.6% identity in 62 aa overlap). Q7TY22 No conserved hypotheticals Rv2708c NC_002945.3 Mycobrowser_v2 CDS 2979097 2980068 . + 0 Mb2729 sigB RNA POLYMERASE SIGMA FACTOR SIGB Mb2729, sigB, len: 323 aa. Equivalent to Rv2710,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). sigB (formerly known as mysB), RNA polymerase sigma factor (see citations below), equivalent to Q59531|ML1014 RNA POLYMERASE SIGMA FACTOR from Mycobacterium leprae (319 aa), FASTA scores: opt: 1935, E(): 1.9e-109, (96.2% identity in 316 aa overlap). Also highly similar to others e.g. Q59553|MYSB from Mycobacterium smegmatis (319 aa), FASTA scores: opt: 1874, E(): 9.1e-106, (92.4% identity in 316 aa overlap); Q9ANT6|SIGB from Brevibacterium flavum (331 aa), FASTA scores: opt: 1525, E(): 9.9e-85, (78.9% identity in 303 aa overlap); Q60158|RPOV from Mycobacterium bovis (528 aa),FASTA scores: opt: 1246, E(): 9.3e-68, (62.85% identity in 315 aa overlap); etc. Contains sigma-70 factors family signatures 1 and 2 (PS00715 and PS00716). And contains possible helix-turn-helix motif at aa 282-303 (Score 1887,+5.61 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY. Q7TY20 No information pathways Rv2710 NC_002945.3 Mycobrowser_v2 CDS 2980201 2980893 . + 0 Mb2730 ideR IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER Mb2730, ideR, len: 230 aa. Equivalent to Rv2711,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). ideR (formerly known as dtxR), iron dependent repressor and activator (see citations below), equivalent to Q9CCB5|ML1013 IRON DEPENDENT REPRESSOR from Mycobacterium leprae (230 aa),FASTA scores: opt: 1365, E(): 3.8e-77, (90.0% identity in 230 aa overlap). Also highly similar to others e.g. Q50379|DTXR from Mycobacterium smegmatis (233 aa), FASTA scores: opt: 1291, E(): 1.4e-72, (86.1% identity in 230 aa overlap); Q9F7T3|IDER from Corynebacterium equii (Rhodococcus equi) (230 aa), FASTA scores: opt: 1130, E(): 1.2e-62, (74.8% identity in 230 aa overlap); P33120|DTXR_CORDI from Corynebacterium diphtheriae (226 aa), FASTA scores: opt: 803, E(): 1.6e-42, (57.85% identity in 230 aa overlap); etc. BELONGS TO THE FUR FAMILY. X2BLC3,P0A673 No regulatory proteins Rv2711 NC_002945.3 Mycobrowser_v2 CDS 3001011 3001625 . - 0 Mb2751c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2751c, -, len: 204 aa. Equivalent to Rv2732c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Probable conserved transmembrane protein, similar to Q49834 hypothetical protein B2235_C1_155 from Mycobacterium leprae (209 aa),FASTA scores: opt: 932, E(): 0, (70.6% identity in 201 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. Q7TY06 No cell wall and cell processes Rv2732c NC_002945.3 Mycobrowser_v2 CDS 2983701 2984675 . + 0 Mb2733 conserved alanine and leucine rich protein Mb2733, -, len: 324 aa. Equivalent to Rv2714, len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 324 aa overlap). Conserved hypothetical ala-, leu-rich protein, equivalent to Q49847|ML1009|B2235_F1_6 HYPOTHETICAL PROTEIN from Mycobacterium leprae (326 aa), FASTA scores: opt: 1881,E(): 5.8e-107, (89.7% identity in 320 aa overlap); and similar to Q49797|MLCB2533.03c|B2126_F1_36 HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa), FASTA scores: opt: 376, E(): 1.2e-15, (30.1% identity in 279 aa overlap); and Q9CC38|ML1306 HYPOTHETICAL PROTEIN from Mycobacterium leprae (274 aa), FASTA scores: opt: 367,E(): 3.6e-15, (29.8% identity in 275 aa overlap). Also highly similar to Q9S2K6|SC7H2.11c HYPOTHETICAL 34.2 KDA PROTEIN from Streptomyces coelicolor (312 aa), FASTA scores: opt: 770, E(): 1.4e-39, (40.9% identity in 286 aa overlap); and similar to Q9ADA5|SCI52.04 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 386, E(): 3e-16, (29.05% identity in 296 aa overlap). Also similar to O33260|Rv2125|MTCY261.21 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (292 aa), FASTA scores: opt: 387, E(): 2.3e-16, (29.45% identity in 292 aa overlap). Q7TY18 No conserved hypotheticals Rv2714 NC_002945.3 Mycobrowser_v2 CDS 3064317 3064949 . + 0 Mb2822 PROBABLE MEMBRANE PROTEIN Mb2822, -, len: 210 aa. Equivalent to Rv2799, len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 210 aa overlap). Probable membrane protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp insertion (*-ggt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa). Q7TXU6 No cell wall and cell processes Rv2799 NC_002945.3 Mycobrowser_v2 CDS 2984734 2985759 . + 0 Mb2734 POSSIBLE HYDROLASE Mb2734, -, len: 341 aa. Equivalent to Rv2715, len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 341 aa overlap). Possible hydrolase (EC 3.-.-.-), showing some similarity with other hydrolases e.g. Q9I5B0|PA0829 PROBABLE HYDROLASE from Pseudomonas aeruginosa (313 aa), FASTA scores: opt: 336,E(): 9.9e-14, (28.05% identity in 289 aa overlap); BAB55888 HYDROLASE (FRAGMENT) from Terrabacter sp. DBF63 (319 aa), FASTA scores: opt: 326, E(): 4.2e-13, (27.95% identity in 290 aa overlap); O52866|CEH|EH SOLUBLE EPOXIDE HYDROLASE from Corynebacterium SP (285 aa), FASTA scores: opt: 325, E(): 4.4e-13, (29.95% identity in 284 aa overlap); etc. Also shows some similarity to P96811|EPHF|Rv0134|MTCI5.08 HYPOTHETICAL 33.8 KDA PROTEINfrom Mycobacterium tuberculosis (300 aa), FASTA scores: E(): 1.8e-10, (27.7% identity in 271 aa overlap). Contains lipases, serine active site motif (PS00120). X2BLN7,P0A573 No intermediary metabolism and respiration Rv2715 NC_002945.3 Mycobrowser_v2 CDS 2985808 2986494 . + 0 Mb2735 conserved protein Mb2735, -, len: 228 aa. Equivalent to Rv2716, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Conserved hypothetical protein, similar to other proteins e.g. Q9RKR0|SCC75A.14 HYPOTHETICAL 23.3 KDA PROTEIN from Streptomyces coelicolor (214 aa), FASTA scores: opt: 447,E(): 4e-22, (44.1% identity in 220 aa overlap); Q9HHG6|PHZF|VNG6408G PHENAZINE BIOSYNTHETIC PROTEIN from Halobacterium sp. strain NRC-1 (299 aa), FASTA scores: opt: 201, E(): 6.1e-06, (30.4% identity in 148 aa overlap) (similarity only at N-terminus); P73125|SLR1019 HYPOTHETICAL 34.1 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (314 aa), FASTA scores: opt: 196, E(): 1.4e-05, (28.5% identity in 298 aa overlap); etc. X2BLC6,P0A5G8 No conserved hypotheticals Rv2716 NC_002945.3 Mycobrowser_v2 CDS 3012994 3013806 . - 0 Mb2764c possible conserved transmembrane alanine rich protein Mb2764c, -, len: 270 aa. Equivalent to Rv2743c,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Possible conserved membrane ala-rich protein, equivalent to Q49833|MLCB33.04c|B2235_C1_148 UNKNOWN PROTEIN from Mycobacterium leprae (123 aa), FASTA scores: opt: 639,E(): 3.3e-31, (74.8% identity in 123 aa overlap). Q7TXZ6 No cell wall and cell processes Rv2743c NC_002945.3 Mycobrowser_v2 CDS 2986503 2986997 . - 0 Mb2736c conserved protein Mb2736c, -, len: 164 aa. Equivalent to Rv2717c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Conserved hypothetical protein, equivalent to Q9CCB8|ML1006 (alias Q49838 but shortened N-terminus) HYPOTHETICAL PROTEIN from Mycobacterium leprae (161 aa), FASTA scores: opt: 797,E(): 2.3e-46, (73.8% identity in 164 aa overlap). Also highly similar to other eukaryotic proteins e.g. O64527|YUP8H12R.14 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (166 aa), FASTA scores: opt: 393, E(): 2.3e-19, (42.4% identity in 158 aa overlap); Q9Y325 CGI-36 PROTEIN from Homo sapiens (Human) (165 aa),FASTA scores: opt: 294, E(): 9.5e-13, (33.95% identity in 159 aa overlap); etc. X2BLN9,Q7TY17 No conserved hypotheticals Rv2717c NC_002945.3 Mycobrowser_v2 CDS 2987049 2987513 . - 0 Mb2737c nrdr probable transcriptional regulatory protein nrdr Mb2737c, -, len: 154 aa. Equivalent to Rv2718c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Conserved hypothetical protein, equivalent to Q49844|ML1005|U2235A|B2235_C2_209 HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 937, E(): 1.5e-52, (92.7% identity in 151 aa overlap). Highly similar to O86848|NRDR_STRCL PUTATIVE REGULATORY PROTEIN from Streptomyces clavuligerus (172 aa), FASTA scores: opt: 750, E(): 1.1e-40, (73.65% identity in 148 aa overlap); O69980|SC4H2.25 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (182 aa), FASTA scores: opt: 725, E(): 4.6e-39, (73.1% identity in 145 aa overlap); Q9KPU0|VC2272 HYPOTHETICAL PROTEIN from Vibrio cholerae (156 aa), FASTA scores: opt: 462, E(): 1.8e-22,(47.3% identity in 148 aa overlap); etc. X2BM29,P67314 No regulatory proteins Rv2718c NC_002945.3 Mycobrowser_v2 CDS 2987676 2988173 . - 0 Mb2738c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb2738c, -, len: 165 aa. Equivalent to Rv2719c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 165 aa overlap). Possible conserved membrane protein, equivalent to Q49846|ML1004|B2235_C3_243 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (164 aa), FASTA scores: opt: 486, E(): 4e-21,(55.2% identity in 163 aa overlap). Q7TY16 No cell wall and cell processes Rv2719c NC_002945.3 Mycobrowser_v2 CDS 2988481 2989134 . + 0 Mb2739 lexA REPRESSOR LEXA Mb2739, lexA, len: 217 aa. Equivalent to Rv2720,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). LexA repressor (EC 3.4.21.88) (see citations below), equivalent to Q49848|LEXA_MYCLE|ML1003|B2235_F2_55 LEXA REPRESSOR from Mycobacterium leprae (217 aa), FASTA scores: opt: 1255,E(): 7.1e-70, (89.8% identity in 216 aa overlap). Also highly similar to others e.g. O69979|LEXA_STRCO|SC4H2.24c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 1034, E(): 2.6e-56, (70.5% identity in 217 aa overlap); O86847|LEXA_STRCL from Streptomyces clavuligerus (239 aa),FASTA scores: opt: 1021, E(): 1.6e-55, (69.1% identity in 217 aa overlap); Q9KAD3|LEXA_BACHD from Bacillus halodurans (207 aa), FASTA scores: opt: 645, E(): 1.5e-32,(47.9% identity in 213 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY S24; ALSO KNOWN AS THE UMUD/LEXA FAMILY. X2BLP2,Q7TY15 No regulatory proteins Rv2720 NC_002945.3 Mycobrowser_v2 CDS 3015836 3016360 . + 0 Mb2768 arga probable l-glutamate alpha-n-acetyltranferase arga (alpha-n-acetylglutamate synthase) Mb2768, -, len: 174 aa. Equivalent to Rv2747, len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Possible transferase (EC 2.-.-.-), equivalent to O05559|ML0978|MLCB33.08 PUTATIVE ACETYLTRANSFERASE from Mycobacterium leprae (180 aa), FASTA scores: opt: 997, E(): 1.2e-57, (86.8% identity in 174 aa overlap). Also similar to various transferases e.g. Q9X8N2|SCE94.27c PUTATIVE ACETYLTRANSFERASE from Streptomyces coelicolor (169 aa), FASTA scores: opt: 656,E(): 1.3e-35, (60.35% identity in 164 aa overlap); C-terminus of Q9K3D6|ARGH(A) ARGININOSUCCINASE AND N-ACETYLGLUTAMATE SYNTHASE from Moritella sp. 2693 (629 aa), FASTA scores: opt: 243, E(): 2e-08, (31.95% identity in 144 aa overlap); C-terminus of Q9JW21|ARGA OR NMA0580 PUTATIVE ACETYLGLUTAMATE SYNTHASE from Neisseria meningitidis serogroup A (436 aa), FASTA scores: opt: 201,E(): 7.8e-06, (32.75% identity in 119 aa overlap); etc. Also similar to hypothetical proteins e.g. O67372|AQ_1359 HYPOTHETICAL 21.1 KDA PROTEIN from Aquifex aeolicus (181 aa), FASTA scores: opt: 348, E(): 1.2e-15, (42.35% identity in 137 aa overlap). Q7TXZ2 No intermediary metabolism and respiration Rv2747 NC_002945.3 Mycobrowser_v2 CDS 3023767 3024519 . - 0 Mb2775c thyx probable thymidylate synthase thyx (ts) (tsase) Mb2775c, -, len: 250 aa. Equivalent to Rv2754c,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q9CBW3|YF14_MYCLE|ML1514 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium leprae (254 aa), FASTA scores: opt: 1351, E(): 1e-84, (81.5% identity in 254 aa overlap). Also highly similar to 40111|YDAP_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (250 aa), FASTA scores: opt: 1071, E(): 1.2e-65, (62.85% identity in 245 aa overlap); Q05259|VG48_BPML5 GENE 48 PROTEIN (GP48) from Mycobacteriophage L5 (243 aa),, FASTA scores: opt: 610,E(): 3.2e-34, (49.55% identity in 220 aa overlap); O64238|VG48_BPMD2 GENE 48 PROTEIN (GP48) from Mycobacteriophage D29 (235 aa), FASTA scores: opt: 593,E(): 4.5e-33, (46.95% identity in 245 aa overlap); etc. BELONGS TO THE THY1 FAMILY. X2BLF4,P66931 No intermediary metabolism and respiration Rv2754c NC_002945.3 Mycobrowser_v2 CDS 2989156 2991255 . - 0 Mb2740c POSSIBLE CONSERVED TRANSMEMBRANE ALANINE AND GLYCINE RICH PROTEIN Mb2740c, -, len: 699 aa. Equivalent to Rv2721c,len: 699 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 699 aa overlap). Possible conserved transmembrane ala-, gly-rich protein, equivalent to Q49837|ML1002|U2235I POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (687 aa), FASTA scores: opt: 2703, E(): 6.6e-135, (60.3% identity in 713 aa overlap). Shows some similaity to Q01377|CSP1 PS1 PROTEIN PRECURSOR (SECRETED PROTEIN) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa), FASTA scores: opt: 276,E(): 3.8e-07, (29.4% identity in 272 aa overlap); and Q9KIJ0 Rv2721c-LIKE PROTEIN from Mycobacterium paratuberculosis (246 aa), FASTA scores: opt: 178, E(): 0.025, (37.5% identity in 120 aa overlap). Q7TY14 No cell wall and cell processes Rv2721c NC_002945.3 Mycobrowser_v2 CDS 2991271 2991519 . + 0 Mb2741 CONSERVED HYPOTHETICAL PROTEIN Mb2741, -, len: 82 aa. Equivalent to Rv2722, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 82 aa overlap). Conserved hypothetical protein, similar to Q9CCB9|ML1001 HYPOTHETICAL PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 154,E(): 0.00053, (37.5% identity in 88 aa overlap). Equivalent to AAK47111 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but shorter by 12 aa. Q7TY13 No conserved hypotheticals Rv2722 NC_002945.3 Mycobrowser_v2 CDS 2991545 2992738 . + 0 Mb2742 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2742, -, len: 397 aa. Equivalent to Rv2723, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Probable conserved integral membrane protein, highly similar to others e.g. Q9Z503|SCC54.23c PUTATIVE INTEGRAL MEMBRANE EXPORT PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 883, E(): 2.4e-48, (46.4% identity in 332 aa overlap); Q9RD18|SCM1.25c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 865,E(): 3.1e-47, (47.55% identity in 324 aa overlap); P96554|Y319_MYXXA INTEGRAL MEMBRANE PROTEIN (PROBABLE) from Myxococcus xanthus (319 aa), FASTA scores: opt: 626,E(): 3.4e-32, (34.65% identity in 323 aa overlap); P42601|YGJT_ECOLI|B3088 from Escherichia coli strain K12 INTEGRAL MEMBRANE PROTEIN (PROBABLE) (321 aa), FASTA scores: opt: 541, E(): 7.7e-27, (35.1% identity in 279 aa overlap); etc. X2BM35,P0A615 No cell wall and cell processes Rv2723 NC_002945.3 Mycobrowser_v2 CDS 2996461 2997405 . - 0 Mb2746c miaA PROBABLE TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE MIAA (IPP TRANSFERASE) (ISOPENTENYL-DIPHOSPHATE:TRNA ISOPENTENYLTRANSFERASE) (IPTASE) (IPPT) Mb2746c, miaA, len: 314 aa. Equivalent to Rv2727c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable miaA, tRNA delta(2)-isopentenylpyrophosphate transferase (EC 2.5.1.8), equivalent to P46811|MIAA_MYCLE|ML0995|B2235_C3_232 TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE from Mycobacterium leprae (311 aa), FASTA scores: opt: 1679,E(): 3.2e-89, (81.85% identity in 314 aa overlap). Also highly similar to many e.g. O69967|MIAA_STRCO|SC4H2.12 from Streptomyces coelicolor (312 aa), FASTA scores: opt: 1006, E(): 1.2e-50, (55.5% identity in 301 aa overlap); O31795|MIAA_BACSU from Bacillus subtilis (314 aa), FASTA scores: opt: 671, E(): 1.9e-31, (38.55% identity in 293 aa overlap);P16384|MIAA_ECOLI|TRPX|B4171 from Escherichia coli strain K12 and Shigella flexneri (316 aa), FASTA scores: opt: 565, E(): 2.3e-25, (35.2% identity in 307 aa overlap);etc. Contains PS00017 ATP/GTP-binding site motif A (P -loop). BELONGS TO THE IPP TRANSFERASE FAMILY. X2BLQ5,P65353 No NC_002945.3 Mycobrowser_v2 CDS 2992767 2993927 . - 0 Mb2743c fadE20 PROBABLE ACYL-CoA DEHYDROGENASE FADE20 Mb2743c, fadE20, len: 386 aa. Equivalent to Rv2724c, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 386 aa overlap). Probable fadE20, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. Q9X7Y2|SC6A5.36 from Streptomyces coelicolor (382 aa), FASTA scores: opt: 1583, E(): 6.9e-94, (62.7% identity in 378 aa overlap); Q9HVY0|PA4435 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 1468, E(): 1.6e-86, (57.65% identity in 380 aa overlap); Q9ABZ1|CC0079 from Caulobacter crescentus (391 aa), FASTA scores: opt: 1298, E(): 1.2e-75, (51.9% identity in 391 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis proteins e.g. O06164|FADE19|Rv2500c|MTCY07A7.06c ACYL-CoA DEHYDROGENASE (394 aa) (34.3% identity in 382 aa overlap). Contains acyl-CoA dehydrogenases signature 2 (PS00073). BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY. Q7TY12 No lipid metabolism Rv2724c NC_002945.3 Mycobrowser_v2 CDS 2994063 2995550 . - 0 Mb2744c hflX PROBABLE GTP-BINDING PROTEIN HFLX Mb2744c, hflX, len: 495 aa. Equivalent to Rv2725c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Probable hflX (hfl for high frequency of lysogenization), GTP-binding protein (EC 3.1.5.-),equivalent to Q9CCC0|ML0997 (alias Q49843|HFLX but longer) POSSIBLE ATP/GTP-BINDING PROTEIN from Mycobacterium leprae (488 aa), FASTA scores: opt: 2562, E(): 1.1e-133, (84.55% identity in 485 aa overlap). Also highly similar to many e.g. Q9XCC1 from Streptomyces fradiae (425 aa), FASTA scores: opt: 1280, E(): 3.2e-63,(57.7% identity in 423 aa overlap); P73965|HFLX|SLR1521 from Synechocystis sp. strain PCC 6803 (534 aa), FASTA scores: opt: 1028, E(): 2.8e-49, (44.7% identity in 414 aa overlap); P25519|HFLX_ECOLI|B4173 from Escherichia coli strain K12 (426 aa), FASTA scores: opt: 916, E(): 3.4e-43,(40.1% identity in 414 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TY11 No NC_002945.3 Mycobrowser_v2 CDS 3084815 3085525 . - 0 Mb2845c CONSERVED HYPOTHETICAL PROTEIN Mb2845c, -, len: 236 aa. Equivalent to Rv2821c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins e.g. Q9X2C9|TM1809 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (247 aa), FASTA scores: opt: 318,E(): 8.2e-15, (39.45% identity in 213 aa overlap); O27152|MTH1080 CONSERVED HYPOTHETICAL PROTEIN from Methanothermobacter thermautotrophicus (245 aa), FASTA scores: opt: 294, E(): 3.9e-13, (34.8% identity in 224 aa overlap); BAB59251|TVG0114661 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (229 aa), FASTA scores: opt: 252,E(): 3.3e-10, (33.8% identity in 225 aa overlap); etc. Q7TXS6 No conserved hypotheticals Rv2821c NC_002945.3 Mycobrowser_v2 CDS 2995567 2996436 . - 0 Mb2745c dapF PROBABLE DIAMINOPIMELATE EPIMERASE DAPF (DAP EPIMERASE) Mb2745c, dapF, len: 289 aa. Equivalent to Rv2726c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable dapF,diaminopimelate epimerase (EC 5.1.1.7), equivalent to P46814|DAPF_MYCLE|ML0996|B2235_C3_233 DIAMINOPIMELATE EPIMERASE from Mycobacterium leprae (296 aa), FASTA scores: opt: 1488, E(): 2.1e-83, (76.05% identity in 292 aa overlap). Also highly similar to O69969|DAPF_STRCO|SC4H2.14 from Streptomyces coelicolor (289 aa), FASTA scores: opt: 439, E(): 1.4e-19, (45.6% identity in 296 aa overlap); and similar to many e.g. O29511|DAPF_ARCFU|AF0747 from Archaeoglobus fulgidus (280 aa), FASTA scores: opt: 310, E(): 9.7e-12, (33.8% identity in 296 aa overlap); Q51564|DAPF_PSEAE|PA5278 from Pseudomonas aeruginosa (276 aa), FASTA scores: opt: 272,E(): 2e-09, (30.15% identity in 292 aa overlap); P08885|DAPF_ECOLI|B3809 from Escherichia coli strain K12 (274 aa), FASTA scores: opt: 266, E(): 4.5e-09, (30.4% identity in 296 aa overlap); etc. BELONGS TO THE DIAMINOPIMELATE EPIMERASE FAMILY. X2BLD2,P63898 No NC_002945.3 Mycobrowser_v2 CDS 2997402 2998097 . - 0 Mb2747c conserved alanine rich protein Mb2747c, -, len: 231 aa. Equivalent to Rv2728c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q49835|ML0994|B2235_C1_162 HYPOTHETICAL PROTEIN from Mycobacterium leprae (232 aa), FASTA scores: opt: 1037,E(): 1.2e-54, (68.55% identity in 232 aa overlap). Also similar to O69964|SC4H2.09 from Streptomyces coelicolor (237 aa), FASTA scores: opt: 300, E(): 7.7e-11, (32.8% identity in 241 aa overlap); and some similarity with other proteins e.g. Q14234|ELN ELASTIN from Homo sapiens (Human) (757 aa), FASTA scores: opt: 161, E(): 0.03,(30.6% identity in 242 aa overlap); P55488|Y4IE HYPOTHETICAL 15.4 KDA PROTEIN from Rhizobium sp. strain NGR234 (135 aa), FASTA scores: opt: 147, E(): 0.061,(34.95% identity in 123 aa overlap). Shows also some similarity with P71657|Rv1387|MTCY21B4.04 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (539 aa), FASTA scores: opt: 159, E(): 0.035, (34.8% identity in 135 aa overlap). Q7TY10 No conserved hypotheticals Rv2728c NC_002945.3 Mycobrowser_v2 CDS 2998206 2999111 . - 0 Mb2748c probable conserved integral membrane alanine valine and leucine rich protein Mb2748c, -, len: 301 aa. Equivalent to Rv2729c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 301 aa overlap). Probable conserved integral membrane ala-, val-, leu-rich protein, similar to P42459|YLEU_CORGL HYPOTHETICAL 29.6 KDA PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum)(270 aa), FASTA scores: opt: 365, E(): 4.7e-15, (30.75% identity in 221 aa overlap); and to other integral membrane proteins (principally from Streptomyces sp.) e.g. Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa),FASTA scores: opt: 365, E(): 5.2e-15, (32.0% identity in 278 aa overlap); Q9S267|SCI30A.06 from Streptomyces coelicolor (297 aa), FASTA scores: opt: 356, E(): 1.8e-14,(31.5% identity in 289 aa overlap); AAK81278|CAC3346 from Clostridium acetobutylicum (472 aa), FASTA scores: opt: 154, E(): 0.038, (24.1% identity in 224 aa overlap); etc. Q7TY09 No cell wall and cell processes Rv2729c NC_002945.3 Mycobrowser_v2 CDS 3024763 3025038 . - 0 Mb2776c hsdS' possible type i restriction/modification system specificity determinant (fragment) hsds.1 (s protein) Mb2776c, hsdS', len: 91 aa. Equivalent to Rv2755c,len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Possible hsdS',fragment of type I restriction/modification system specificity determinant (S protein), similar to the N-terminus of other hsdS proteins e.g. O34140|HSDS from Klebsiella pneumoniae (439 aa), FASTA scores: opt: 303,E(): 2.1e-13, (46.65% identity in 90 aa overlap); P72419|STY|SBLI from Salmonella typhimurium (434 aa),FASTA scores: opt: 278, E(): 1.1e-11, (47.65% identity in 86 aa overlap); and Q9P9X9|XF2741 from Xylella fastidiosa (412 aa), FASTA scores: opt: 144, E(): 0.015, (31.7% identity in 82 aa overlap). Also some similarity with O33303|Rv2761c|MTV002.26c|HSDS POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM SPECIFICITY DETERMINANT from Mycobacterium tuberculosis (364 aa), FASTA scores: opt: 145, E(): 0.012, (29.9% identity in 87 aa overlap). Q7TXY6 No NC_002945.3 Mycobrowser_v2 CDS 2999662 3001014 . + 0 Mb2750 conserved alanine and arginine rich protein Mb2750, -, len: 450 aa. Equivalent to Rv2731, len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 450 aa overlap). Conserved hypothetical ala-, arg-rich protein, highly similar in part to Q49849|B2235_F2_77 HYPOTHETICAL PROTEIN from Mycobacterium leprae (266 aa), FASTA scores: opt: 368,E(): 1e-10, (73.5% identity in 83 aa overlap); and Q9KXN9|SC9C5.35 HYPOTHETICAL 6.5 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (58 aa), FASTA scores: opt: 214, E(): 0.00065, (51.7% identity in 58 aa overlap). Also similar to Q9L296|SCL2.01 HYPOTHETICAL 37.4 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (328 aa), FASTA scores: opt: 843, E(): 3.7e-33, (45.95% identity in 296 aa overlap) (but N-terminus shorter); and shows some similarity with other proteins e.g. Q26938 KINETOPLAST-ASSOCIATED PROTEIN (KAP) from Trypanosoma cruzi (1052 aa), FASTA scores: opt: 223, E(): 0.0022,(30.3% identity in 297 aa overlap). Start site chosen by RBS and to avoid overlap, although there are several other possible start sites further upstream. Q7TY07 No conserved hypotheticals Rv2731 NC_002945.3 Mycobrowser_v2 CDS 3001622 3003160 . - 0 Mb2752c CONSERVED HYPOTHETICAL ALANINE, ARGININE-RICH PROTEIN Mb2752c, -, len: 512 aa. Equivalent to Rv2733c,len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Conserved hypothetical ala-, arg-rich protein. Similar to other hypothetical proteins from a range of organisms e.g. Y195_MYCLE|Q49842 hypothetical 56.0 kd protein b2235_c2_195 from Mycobacterium leprae (516 aa), FASTA scores: opt: 2689, E(): 0, (80.4% identity in 509 aa overlap). X2BM44,P67086 No conserved hypotheticals Rv2733c NC_002945.3 Mycobrowser_v2 CDS 3003457 3004311 . + 0 Mb2753 CONSERVED HYPOTHETICAL PROTEIN Mb2753, -, len: 284 aa. Equivalent to Rv2734, len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Conserved hypothetical protein, highly similar to various proteins e.g. Q984J2|MLR7981 ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 877, E(): 9e-50, (52.45% identity in 246 aa overlap) (N-terminus longer); Q98DH1|MLL4707 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (249 aa),FASTA scores: opt: 829, E(): 1.1e-46, (50.4% identity in 244 aa overlap); AAK65865|SMA2239 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (259 aa), FASTA scores: opt: 796, E(): 1.5e-44, (50.0% identity in 252 aa overlap); etc. Q7TY05 No conserved hypotheticals Rv2734 NC_002945.3 Mycobrowser_v2 CDS 3004196 3005188 . - 0 Mb2754c CONSERVED HYPOTHETICAL PROTEIN Mb2754c, -, len: 330 aa. Equivalent to Rv2735c,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Conserved hypothetical protein, showing some similarity with Q98DH2|MLR4706 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (302 aa), FASTA scores: opt: 140,E(): 0.062, (27.0% identity in 200 aa overlap); and Q9PHA1|XF0043 HYPOTHETICAL PROTEIN from Xylella fastidiosa (293 aa), FASTA scores: opt: 120, E(): 1.2, (30.75% identity in 117 aa overlap). Q7TY04 No conserved hypotheticals Rv2735c NC_002945.3 Mycobrowser_v2 CDS 3005198 3005722 . - 0 Mb2755c recX REGULATORY PROTEIN RECX Mb2755c, recX, len: 174 aa. Equivalent to Rv2736c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Probable recX,regulatory protein (see citation below), equivalent to P37859|RECX_MYCLE|ML0988|U2235B REGULATORY PROTEIN RECX from Mycobacterium leprae (171 aa), FASTA scores: opt: 848, E(): 2e-46, (77.0% identity in 174 aa overlap); and CAA67596|RECX|P94965|RECX_MYCSM REGULATORY PROTEIN RECX from Mycobacterium smegmatis (188 aa), FASTA scores: opt: 679, E(): 8.8e-36, (66.45% identity in 164 aa overlap). Also similar (or highly similar to) others e.g. O50488|RECX_STRCO|SC4H8.09 from Streptomyces coelicolor (188 aa), FASTA scores: opt: 371, E(): 1.9e-16, (42.7% identity in 164 aa overlap); Q9LCZ3|RECX from Xanthomonas campestris pv. citri (162 aa), FASTA scores: opt: 189,E(): 4.4e-05, (32.45% identity in 151 aa overlap); P37860|RECX_PSEAE|PA3616 from Pseudomonas aeruginosa (153 aa), FASTA scores: opt: 159, E(): 0.0032, (30.65% identity in 137 aa overlap); etc. BELONGS TO THE RECX FAMILY. X2BLD9,P0A5U9 No NC_002945.3 Mycobrowser_v2 CDS 3008659 3009825 . - 0 Mb2759c POSSIBLE ALANINE RICH TRANSFERASE Mb2759c, -, len: 388 aa. Equivalent to Rv2739c,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Possible ala-rich transferase (EC 2.-.-.-), equivalent to Q49841|ML0985|MLCB33.02c|U2235C POSSIBLE GLYCOSYLTRANSFERASE from Mycobacterium leprae (392 aa),FASTA scores: opt: 2112, E(): 5.1e-114, (80.95% identity in 388 aa overlap). Shows some similarity with other transferases e.g. Q9S1V2|SCJ4.21 PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (407 aa), FASTA scores: opt: 290, E(): 2e-09, (27.75% identity in 382 aa overlap); Q9RYI3|DRA0329 PUTATIVE GLYCOSYLTRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 267,E(): 4.3e-08, (29.05% identity in 396 aa overlap); P96560|GTFC GLYCOSYLTRANSFERASE from Amycolatopsis orientalis (409 aa), FASTA scores: opt: 253, E(): 2.7e-07,(27.75% identity in 418 aa overlap); etc. Equivalent to AAK47130 from Mycobacterium tuberculosis strain CDC1551 (420 aa) but shorter 32 aa. Q7TY01 No intermediary metabolism and respiration Rv2739c NC_002945.3 Mycobrowser_v2 CDS 3009869 3010318 . + 0 Mb2760 ephg epoxide hydrolase Mb2760, -, len: 149 aa. Equivalent to Rv2740, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Conserved hypothetical protein, equivalent, but shorter 17 aa, to Q9CCC2|ML0984 (alias Q49850 but longer) HYPOTHETICAL PROTEIN from Mycobacterium leprae (164 aa), FASTA scores: opt: 481, E(): 9.7e-26, (52.0% identity in 150 aa overlap). Q7TY00 No virulence, detoxification, adaptation Rv2740 NC_002945.3 Mycobrowser_v2 CDS 3010528 3012042 . + 0 Mb2761 PE_PGRS47 pe-pgrs family protein pe_pgrs47 Mb2761, PE_PGRS47, len: 504 aa. Equivalent to Rv2741, len: 525 aa, from Mycobacterium tuberculosis strain H37Rv, (94.37% identity in 515 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Q10637|YD25_MYCTU|Rv1325c|MT1367|MTCY130.10c HYPOTHETICAL PE-PGRS FAMILY PROTEIN (603 aa), FASTA scores: opt: 1936, E(): 1.1e-71, (56.95% identity in 611 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a diferent 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv (504 aa versus 525 aa). NO PE motif. Q7TXZ9 No NC_002945.3 Mycobrowser_v2 CDS 3012066 3012314 . - 0 Mb2762c CONSERVED HYPOTHETICAL ARGININE RICH PROTEIN [SECOND PART] Mb2762c, -, len: 82 aa. Equivalent to 3' end of Rv2742c, len: 277 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Conserved hypothetical arg-rich protein. Extreme N-terminus is highly similar to the N-teminus of Q9CCC1ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 183, E(): 0.00052,(71.05% identity in 38 aa overlap); and to the downstream ORF O33281|Rv2738c|MTV002.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (68 aa), FASTA scores: opt: 200, E(): 5.5e-05, (78.4% identity in 37 aa overlap). Questionable ORF. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts,Mb2762c and Mb2763c. Q7TXZ8 No NC_002945.3 Mycobrowser_v2 CDS 3012335 3012922 . - 0 Mb2763c CONSERVED HYPOTHETICAL ARGININE RICH PROTEIN [FIRST PART] Mb2763c, -, len: 195 aa. Equivalent to 5' end of Rv2742c, len: 277 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 195 aa overlap). Conserved hypothetical arg-rich protein. Extreme N-terminus is highly similar to the N-teminus of Q9CCC1ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 183, E(): 0.00052,(71.05% identity in 38 aa overlap); and to the downstream ORF O33281|Rv2738c|MTV002.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (68 aa), FASTA scores: opt: 200, E(): 5.5e-05, (78.4% identity in 37 aa overlap). Questionable ORF. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts,Mb2762c and Mb2763c. Q7TXZ7 No NC_002945.3 Mycobrowser_v2 CDS 3029211 3029483 . - 0 Mb2783c CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb2783c, -, len: 90 aa. Equivalent to 3' end of Rv2762c, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Conserved hypothetical protein, similar to C-terminus of hypothetical proteins: Q9A380|CC3324 from Caulobacter crescentus (409 aa), FASTA scores: opt: 181, E(): 9.8e-05,(43.55% identity in 101 aa overlap); Q98KQ4|MLR1373 from Rhizobium loti (Mesorhizobium loti) (399 aa), FASTA scores: opt: 174, E(): 0.00028, (46.35% identity in 82 aa overlap); and Q9HZZ9|PA2844 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 158, E(): 0.0033, (40.0% identity in 80 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis, a single base transition (c-t) splits Rv2762c into 2 parts, Mb2783c and Mb2784c. Q7TXY0 No NC_002945.3 Mycobrowser_v2 CDS 3013825 3014637 . - 0 Mb2765c 35kd_ag CONSERVED 35 KDA ALANINE RICH PROTEIN Mb2765c, 35kd_ag, len: 270 aa. Equivalent to Rv2744c, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 270 aa overlap). 35kd_ag,conserved ala-rich protein 35-kd antigen (see citation below). N-terminal part is equivalent to Q49840|MLCB33.06c|B2235_C2_187 HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FASTA scores: opt: 789,E(): 3.4e-35, (85.05% identity in 147 aa overlap); and C-terminal part equivalent to Q49845|MLCB33.05c|B2235_C3_214 HYPOTHETICAL PROTEIN from Mycobacterium leprae (114 aa), FASTA scores: opt: 465,E(): 3.6e-18, (65.8% identity in 114 aa overlap); note that these two proteins from Mycobacterium leprae are adjacent. Shows some similarity with Q55707||Y617_SYNY3|SLL0617 HYPOTHETICAL 28.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (267 aa), FASTA scores: opt: 155, E(): 0.19, (23.4% identity in 252 aa overlap); and C-terminus of Q9L4N1|EMM M PROTEIN from Streptococcus equisimilis (592 aa), FASTA scores: opt: 165, E(): 0.11, (23.45% identity in 260 aa overlap). C-terminus also similar to AAK45945|MT1676 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (85 aa), FASTA scores: opt: 159, E(): 0.047, (50.9% identity in 55 aa overlap). Q7TXZ5 No NC_002945.3 Mycobrowser_v2 CDS 3014767 3015105 . - 0 Mb2766c clgr transcriptional regulatory protein clgr Mb2766c, -, len: 112 aa. Equivalent to Rv2745c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Possible transcriptional regulatory protein, highly similar to O86815|SC7C7.10 HYPOTHETICAL 13.6 KDA PROTEIN from Streptomyces coelicolor (126 aa), FASTA scores: opt: 300,E(): 2.4e-13, (60.45% identity in 86 aa overlap); and highly similar to other transcriptional regulators e.g. Q9X7S1|SC5H1.13c POSSIBLE DNA-BINDING PROTEIN from Streptomyces coelicolor (157 aa), FASTA scores: opt: 254,E(): 3.3e-10, (50.0% identity in 94 aa overlap) (N-terminus longer); Q9F885|POPR TRANSCRIPTIONAL REGULATOR from Streptomyces lividans (148 aa), FASTA scores: opt: 248, E(): 7.8e-10, (53.6% identity in 97 aa overlap) (N-terminus longer); Q9FCH1|2SCD46.12 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (141 aa), FASTA scores: opt: 162, E(): 0.00038, (33.0% identity in 106 aa overlap); etc. Q7TXZ4 No regulatory proteins Rv2745c NC_002945.3 Mycobrowser_v2 CDS 3015176 3015805 . - 0 Mb2767c pgsA3 PROBABLE PGP SYNTHASE PGSA3 (CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) Mb2767c, pgsA3, len: 209 aa. Equivalent to Rv2746c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable pgsA3, PGP synthase (EC 2.7.8.5) (see citation below), transmembrane protein, equivalent, but longer 19 aa, to Q49839|O08087|PGSA|ML0979 PGSA from Mycobacterium leprae (193 aa), FASTA scores: opt: 925, E(): 3.7e-53, (77.15% identity in 188 aa overlap). Also highly similar to O86813|PGSA PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE from Streptomyces coelicolor (263 aa), FASTA scores: opt: 692,E(): 6.6e-38, (57.85% identity in 185 aa overlap) (has its N-terminus longer); and similar to others (generally with N-terminus shorter) e.g. Q99XI0|PGSA|SPY2196 PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE from Streptococcus pyogenes (180 aa), FASTA scores: opt: 368, E(): 5.4e-17,(39.9% identity in 168 aa overlap); Q9ZE96|PGSA_RICPR|PGSA|RP049 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Rickettsia prowazekii (181 aa), FASTA scores: opt: 343, E(): 2.3e-15, (40.1% identity in 172 aa overlap); P06978|PGSA_ECOLI|PGSA|B1912|Z3000|ECS2650 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Escherichia coli strains K12 and O157:H7 (181 aa), FASTA scores: opt: 322, E(): 5.3e-14, (34.45% identity in 180 aa overlap); etc. Also some similarity to PGSA2|Rv1822|MTCY1A11.21c PROBABLE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Mycobacterium tuberculosis (209 aa), FASTA score: (27.1% identity in 166 aa overlap). Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. Q7TXZ3 No NC_002945.3 Mycobrowser_v2 CDS 3022796 3023698 . - 0 Mb2774c dapA PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) (DIHYDRODIPICOLINATE SYNTHETASE) Mb2774c, dapA, len: 300 aa. Equivalent to Rv2753c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable dapA,dihydrodipicolinate synthase (EC 4.2.1.52), equivalent to Q9CBW4|DAPA_MYCLE|ML1513 DIHYDRODIPICOLINATE SYNTHASE from Mycobacterium leprae (300 aa), FASTA scores: opt: 1699,E(): 2.2e-98, (86.65% identity in 300 aa overlap). Also highly similar to many e.g. P19808|DAPA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (301 aa), FASTA scores: opt: 1089, E(): 2e-60, (58.7% identity in 288 aa overlap); O86841|DAPA_STRCO|SC9A10.08 from Streptomyces coelicolor (299 aa), FASTA scores: opt: 1044,E(): 1.3e-57, (55.75% identity in 287 aa overlap); P05640|DAPA_ECOLI (292 aa), FASTA scores: opt: 515, E(): 0, (33.8% identity in 287 aa overlap); etc. Contains PS00665 and PS00666 Dihydrodipicolinate synthetase signatures 1 and 2. BELONGS TO THE DHDPS FAMILY. X2BLS1,P63946 No NC_002945.3 Mycobrowser_v2 CDS 3016429 3019080 . - 0 Mb2769c ftsK POSSIBLE CELL DIVISION TRANSMEMBRANE PROTEIN FTSK Mb2769c, ftsK, len: 883 aa. Equivalent to Rv2748c,len: 883 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 883 aa overlap). Possible ftsK, cell division transmembrane protein, equivalent to O05560|ML0977|FTSK|MLCB33.09c CELL DIVISION PROTEIN from Mycobacterium leprae (886 aa), FASTA scores: opt: 3147,E(): 7.9e-175, (78.1% identity in 885 aa overlap). Also similar to other members of the spoIIIE/ftsK family e.g. O86810|SC7C7.05 FTSK HOMOLOG from Streptomyces coelicolor (929 aa), FASTA scores: opt: 2256, E(): 3.8e-123, (49.05% identity in 924 aa overlap); Q9CF25|FTSK CELL DIVISION PROTEIN FTSK from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (763 aa), FASTA scores: opt: 1438,E(): 9.1e-76, (37.7% identity in 751 aa overlap); AAK75005|Q97RE4|SP0878 SPOE FAMILY PROTEIN from Streptococcus pneumoniae (767 aa), FASTA scores: opt: 1405, E(): 7.5e-74, (48.0% identity in 477 aa overlap); P46889|FTSK_ECOLI|B0890 from Escherichia coli strain K12 (1329 aa), FASTA scores: opt: 759, E(): 0, (44.5% identity in 537 aa overlap) (similarity in C-terminal half); etc. Equivalent to AAK47139 from Mycobacterium tuberculosis strain CDC1551 (968 aa) but shorter 85 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FTSK/SPOIIIE FAMILY. Q7TXZ1 No NC_002945.3 Mycobrowser_v2 CDS 3019079 3019393 . + 0 Mb2770 conserved protein Mb2770, -, len: 104 aa. Equivalent to Rv2749, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Conserved hypothetical protein, showing some similarity with Q9I1R9|PA2198 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (114 aa), FASTA scores: opt: 157, E(): 0.00081,(35.0% identity in 100 aa overlap); and O86332|Rv0793|MTV042.03 HYPOTHETICAL 11.2 KDA PROTEIN from Mycobacterium tuberculosis (101 aa), FASTA scores: opt: 143, E(): 0.0062, (26.9% identity in 93 aa overlap). Q7TXZ0 No conserved hypotheticals Rv2749 NC_002945.3 Mycobrowser_v2 CDS 3019390 3020208 . + 0 Mb2771 PROBABLE DEHYDROGENASE Mb2771, -, len: 272 aa. Equivalent to Rv2750, len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Probable dehydrogenase (EC 1.-.-.-), highly similar to other dehydrogenases/reductases e.g. Q9L5X5|COX CHOLESTEROL OXIDASE from Nocardioides simplex (Arthrobacter simplex) (270 aa), FASTA scores: opt: 836, E(): 1.8e-43, (55.7% identity in 264 aa overlap); Q9RA05|LIMC CARVEOL DEHYDROGENASE from Rhodococcus erythropolis (277 aa),FASTA scores: opt: 792, E(): 8.6e-41, (48.55% identity in 274 aa overlap); Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE from Streptomyces antibioticus (273 aa), FASTA scores: opt: 435, E(): 3.7e-19, (35.75% identity in 263 aa overlap); etc. Also highly similar to AAK44941MT0715 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Mycobacterium tuberculosis strain CDC1551 (275 aa), FASTA scores: opt: 702, E(): 2.4e-35, (44.45% identity in 270 aa overlap); and similar to many other Mycobacterium tuberculosis dehydrogenases. Q7TXY9 No intermediary metabolism and respiration Rv2750 NC_002945.3 Mycobrowser_v2 CDS 3020212 3021102 . + 0 Mb2772 conserved protein Mb2772, -, len: 296 aa. Equivalent to Rv2751, len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Conserved hypothetical protein, similar in part to others e.g. Q98LR1|MLR0915 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (299 aa), FASTA scores: opt: 279,E(): 1.6e-11, (32.85% identity in 210 aa overlap); Q9FBX1|SC8E7.10 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (283 aa), FASTA scores: opt: 232,E(): 2.4e-08, (27.9% identity in 269 aa overlap); Q9FMY9 HYPOTHETICAL PROTEIN (GENOMIC DNA, CHROMOSOME 5, P1 CLONE:MJB21) from Arabidopsis thaliana (Mouse-ear cress) (370 aa), FASTA scores: opt: 205, E(): 2.1e-06, (28.9% identity in 211 aa overlap); etc. Also similar in part to several proteins from Mycobacterium tuberculosis: P72053|Rv3787c|MTCY13D12.21 HYPOTHETICAL 33.4 KDA PROTEIN (308 aa), FASTA scores: opt: 266, E(): 1.3e-10, (29.6% identity in 267 aa overlap); O53795|MBE50c|Rv0731c|MTV041.05c HYPOTHETICAL 34.9 KDA PROTEIN (318 aa), FASTA scores: opt: 266, E(): 1.3e-10,(32.05% identity in 281 aa overlap); O53841|Rv0830|MTV043.22 HYPOTHETICAL 33.4 KDA PROTEIN (301 aa), FASTA scores: opt: 263, E(): 2e-10, (31.3% identity in 262 aa overlap); etc. BELONGS TO THE MTCY13D12.21 / MTCY210.45C / MTCY78.29C FAMILY. Q7TXY8 No conserved hypotheticals Rv2751 NC_002945.3 Mycobrowser_v2 CDS 3021089 3022765 . - 0 Mb2773c CONSERVED HYPOTHETICAL PROTEIN Mb2773c, -, len: 558 aa. Equivalent to Rv2752c,len: 558 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 558 aa overlap). Conserved hypothetical protein, equivalent to Q9CBW5|ML1512 HYPOTHETICAL PROTEIN from Mycobacterium leprae (558 aa),FASTA scores: opt: 3301, E(): 1.2e-195, (89.05% identity in 558 aa overlap). Also highly similar to other hypothetical proteins from a wide range of prokaryotes e.g. CAC19480|P54122|YOR4_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (718 aa), FASTA scores: opt: 2142, E(): 3.5e-124, (57.2% identity in 554 aa overlap) (N-terminus longer); O86842|SC9A10.09 from Streptomyces coelicolor (561 aa), FASTA scores: opt: 2077,E(): 2.9e-120, (55.95% identity in 556 aa overlap); Q9ZI80 from Streptomyces toyocaensis (528 aa), FASTA scores: opt: 1843, E(): 7.3e-106, (52.45% identity in 528 aa overlap) (N-terminus shorter 30 aa); etc. Q7TXY7 No conserved hypotheticals Rv2752c NC_002945.3 Mycobrowser_v2 CDS 3025035 3026657 . - 0 Mb2777c hsdM POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM DNA METHYLASE HSDM (M PROTEIN) (DNA METHYLTRANSFERASE) Mb2777c, hsdM, len: 540 aa. Equivalent to Rv2756c,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 540 aa overlap). Possible hsdM, type I restriction/modification system DNA methylase (M protein) (EC 2.1.1.-), highly similar to others e.g. Q9P9X8|XF2742 from Xylella fastidiosa (519 aa), FASTA scores: opt: 1613,E(): 1.9e-96, (52.3% identity in 543 aa overlap); O34139|HSDM from Klebsiella pneumoniae (539 aa), FASTA scores: opt: 1267, E(): 4.4e-74, (45.9% identity in 549 aa overlap); P72418|STY|SBLI|HSDM from Salmonella typhimurium (539 aa), FASTA scores: opt: 1263, E(): 8e-74, (45.7% identity in 549 aa overlap); etc. Possible alternative start site (GTG) overlapping with termination codon of previous ORF 90 bp upstream. Note that the corresponding endonuclease (M protein) does not appear to be present in Mycobacterium tuberculosis. Q7TXY5 No NC_002945.3 Mycobrowser_v2 CDS 3026744 3027160 . - 0 Mb2778c vapc21 possible toxin vapc21 Mb2778c, -, len: 138 aa. Equivalent to Rv2757c,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Conserved hypothetical protein, similar to several other M. tuberculosis hypothetical proteins e.g. P96411|Rv0229c| MTCY08D5.24c (226 aa), FASTA scores: opt: 354, E(): 4.6e-18, (45.25% identity in 137 aa overlap) (N-terminus longer 89 aa); P95007|RV2546|MTCY159.10c (137 aa), FASTA scores: opt: 265, E(): 7.5e-12, (38.5% identity in 135 aa overlap); O07228|Rv0301|MTCY63.06 (141 aa), FASTA scores: opt: 259, E(): 2.1e-11, (42.4% identity in 132 aa overlap); etc. Q7TXY4 No virulence, detoxification, adaptation Rv2757c NC_002945.3 Mycobrowser_v2 CDS 3027157 3027423 . - 0 Mb2779c vapb21 possible antitoxin vapb21 Mb2779c, -, len: 88 aa. Equivalent to Rv2758c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. P95008|Rv2545 (92 aa), FASTA scores: opt: 151, E(): 0.00028, (66.65% identity in 45 aa overlap); Q10771|YF60_MYCTU|RV1560|MT1611|MTCY48.05c (72 aa), FASTA scores: opt: 106, E(): 0.52, (39.15% identity in 46 aa overlap); O06565|Rv1113|MTCY22G8.02 (65 aa), FASTA scores: opt: 97, E(): 2.2, (33.35% identity in 69 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Q7TXY3 No virulence, detoxification, adaptation Rv2758c NC_002945.3 Mycobrowser_v2 CDS 3051660 3053423 . + 0 Mb2810 CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN Mb2810, -, len: 587 aa. Equivalent to Rv2787, len: 587 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 587 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q9CCI1|ML0798 HYPOTHETICAL PROTEIN from Mycobacterium leprae (592 aa),FASTA scores: opt: 2994, E(): 6.9e-179, (76.5% identity in 587 aa overlap); and similar in part to other proteins from Mycobacterium leprae e.g. O33082|MLCB628.11 HYPOTHETICAL 52.0 KDA PROTEIN (478 aa), FASTA scores: opt: 481, E(): 2.3e-22, (30.95% identity in 294 aa overlap). Also similar in part to O86637|SC3C3.03c HYPOTHETICAL 112.1 KDA PROTEIN from Streptomyces coelicolor (1083 aa),FASTA scores: opt: 488, E(): 1.5e-22, (28.95% identity in 297 aa overlap). And similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 625, E(): 2.2e-31, (34.05% identity in 320 aa overlap); O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 453,E(): 1.6e-20, (29.2% identity in 370 aa overlap); P96217|Rv3860|MTCY01A6.08c (390 aa), FASTA scores: opt: 443, E(): 4.7e-20, (29.95% identity in 354 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TXV7 No conserved hypotheticals Rv2787 NC_002945.3 Mycobrowser_v2 CDS 3027449 3027844 . - 0 Mb2780c vapc42 possible toxin vapc42. contains pin domain. Mb2780c, -, len: 131 aa. Equivalent to Rv2759c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, highly similar to three M. tuberculosis hypothetical proteins O07769|Y609_MYCTU|Rv0609|MT0638|MTCY19H5.13c (133 aa),FASTA scores: opt: 364, E(): 5.1e-18, (49.6% identity in 131 aa overlap); P96914|Y624_MYCTU|Rv0624|MT0652|MTCY20H10.05 (131 aa),FASTA scores: opt: 324, E(): 2.9e-15, (42.85% identity in 126 aa overlap); and Q10874|YJ82_MYCTU|Rv1982c|MT2034|MTCY39.37 (139 aa), FASTA scores: opt: 271, E(): 1.4e-11, (38.6% identity in 127 aa overlap). Also similar to other hypothetical proteins from other bacteria e.g. CAC45376|SMC00900 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (128 aa), FASTA scores: opt: 286,E(): 1.2e-12, (39.55% identity in 129 aa overlap); Q981I7|MLL9357 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (131 aa), FASTA scores: opt: 257,E(): 1.2e-10, (36.35% identity in 132 aa overlap); Q9AAG1|CC0639 HYPOTHETICAL PROTEIN from Caulobacter crescentus (131 aa), FASTA scores: opt: 217, E(): 6.9e-08,(33.35% identity in 132 aa overlap); etc. X2BLF7,P67243 No virulence, detoxification, adaptation Rv2759c NC_002945.3 Mycobrowser_v2 CDS 3027841 3028110 . - 0 Mb2781c vapb42 possible antitoxin vapb42 Mb2781c, -, len: 89 aa. Equivalent to Rv2760c, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Conserved hypothetical protein, showing some similarity with two hypothetical proteins from Mycobacterium tuberculosis O07770|Rv0608|MTCY19H5.14c (81 aa), FASTA scores: opt: 128, E(): 0.057, (37.5% identity in 88 aa overlap); and P96913|Rv0623|MTCY20H10.04 (84 aa), FASTA scores: opt: 99,E(): 5.5, (37.1% identity in 89 aa overlap). Also showing some similarity with CAC45377|SMC00899 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (84 aa), FASTA scores: opt: 116,E(): 0.38, (36.25% identity in 91 aa overlap). Q7TXY2 No virulence, detoxification, adaptation Rv2760c NC_002945.3 Mycobrowser_v2 CDS 3028120 3029214 . - 0 Mb2782c hsdS POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM SPECIFICITY DETERMINANT HSDS (S PROTEIN) Mb2782c, hsdS, len: 364 aa. Equivalent to Rv2761c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Possible hsdS, type I restriction/modification system specificity determinant (S protein), similar in part to other hsdS protein (S PROTEINS) e.g. Q9P9X9|XF2741 from Xylella fastidiosa (412 aa), FASTA scores: opt: 252, E(): 7.4e-09, (24.95% identity in 401 aa overlap); N-terminus of Q9RC12 TYPE I S-SUBUNIT from Lactobacillus delbrueckii (subsp. lactis) (389 aa), FASTA scores: opt: 232, E(): 1.4e-07, (28.1% identity in 185 aa overlap); N-terminus of P72419|STY|SBLI from Salmonella typhimurium (434 aa), FASTA scores: opt: 221, E(): 8e-07, (28.45% identity in 130 aa overlap); C-terminus of P17222|PRRB_ECOLI from Escherichia coli strain CTR5X (401 aa), FASTA scores: opt: 197, E(): 2.8e-05, (27.05% identity in 148 aa overlap); etc. SEEMS TO BELONG TO TYPE-I RESTRICTION SYSTEM S METHYLASE FAMILY. Q7TXY1 No NC_002945.3 Mycobrowser_v2 CDS 3029704 3030183 . - 0 Mb2785c dfrA dihydrofolate reductase dfra (dhfr) (tetrahydrofolate dehydrogenase) Mb2785c, dfrA, len: 159 aa. Equivalent to Rv2763c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable dfrA (alternate gene name: folA), dihydrofolate reductase (EC 1.5.1.3), equivalent to O30463|FOLA DIHYDROFOLATE REDUCTASE from Mycobacterium avium (see citation below) (181 aa), FASTA scores: opt: 802, E(): 4.5e-48, (70.2% identity in 161 aa overlap); and Q9CBW1|FOLA|ML1518 DIHYDROFOLATE REDUCTASE from Mycobacterium leprae (165 aa), FASTA scores: opt: 782, E(): 1e-46, (70.55% identity in 163 aa overlap). Also highly similar to many e.g. Q9K168|DYR_NEIMB|FOLA|NMB0308 from Neisseria meningitidis (serogroup B) (162 aa), FASTA scores: opt: 469, E(): 3.8e-25, (46.65% identity in 163 aa overlap); P12833|DYR3_SALTY|DHFRIII from Salmonella typhimurium (162 aa), FASTA scores: opt: 367, E(): 4e-18, (45.4% identity in 141 aa overlap); Q59408|DYRC_ECOLI|DHFRXIII from Escherichia coli strain RA33.2 (165 aa), FASTA scores: opt: 313, E(): 2.2e-14, (41.9% identity in 136 aa overlap); etc. Contains PS00075 Dihydrofolate reductase signature. BELONGS TO THE DIHYDROFOLATE REDUCTASE FAMILY. X2BLG2,P0A547 No NC_002945.3 Mycobrowser_v2 CDS 3069820 3070011 . + 0 Mb2829 POSSIBLE MEMBRANE PROTEIN Mb2829, -, len: 63 aa. Equivalent to Rv2806, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Possible membrane protein, sharing no homology. Q7TXT9 No cell wall and cell processes Rv2806 NC_002945.3 Mycobrowser_v2 CDS 3030254 3031045 . - 0 Mb2786c thyA PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Mb2786c, thyA, len: 263 aa. Equivalent to Rv2764c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 263 aa overlap). Probable thyA,thymidylate synthase (EC 2.1.1.45), equivalent to Q9CBW0|TYSY_MYCLE|THYA|ML1519 THYMIDYLATE SYNTHASE from Mycobacterium leprae (266 aa), FASTA scores: opt: 1602,E(): 5.9e-102, (85.5% identity in 262 aa overlap). Also highly similar to many e.g. P00470|TYSY_ECOLI|B2827|Z4144|ECS3684|BAB37107|AAG57938 from Escherichia coli strains K12 and O157:H7 (264 aa),FASTA scores: opt: 1309, E(): 5.9e-82, (66.65% identity in 261 aa overlap); P48464|TYSY_SHIFL|THYA from Shigella flexneri (264 aa), FASTA scores: opt: 1303, E(): 1.5e-81,(65.9% identity in 261 aa overlap); P54081|TYSB_BACAM|THYB|THYBA from Bacillus amyloliquefaciens (264 aa), FASTA scores: opt: 1235, E(): 6.7e-77, (66.65% identity in 261 aa overlap); etc. Contains PS00091 Thymidylate synthase active site. BELONGS TO THE THYMIDYLATE SYNTHASE FAMILY. X2BLW1,P67045 No NC_002945.3 Mycobrowser_v2 CDS 3031210 3031947 . + 0 Mb2787 PROBABLE ALANINE RICH HYDROLASE Mb2787, -, len: 245 aa. Equivalent to Rv2765, len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Probable ala-rich hydrolase (EC 3.-.-.-), similar to various hydrolases or hypothetical proteins e.g. Q9KYM6|SC9H11.13c PUTATIVE HYDROLASE from Streptomyces coelicolor (251 aa), FASTA scores: opt: 630, E(): 1.4e-33, (43.1% identity in 246 aa overlap); Q9A5T9|CC2358 DIENELACTONE HYDROLASE FAMILY PROTEIN from Caulobacter crescentus (286 aa), FASTA scores: opt: 592, E(): 4.5e-31, (38.45% identity in 242 aa overlap); Q9FCF1|2SCD46.33 PUTATIVE HYDROLASE (DIENELACTONE HYDROLASE FAMILY) from Streptomyces coelicolor (254 aa), FASTA scores: opt: 500, E(): 3.9e-25,(37.7% identity in 252 aa overlap); P73163|DLHH_SYNY3|SLL1298 PUTATIVE CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (EC 3.1.1.45) from Synechocystis sp. (strain PCC 6803) (246 aa), FASTA scores: opt: 276, E(): 1.3e-10, (26.95% identity in 230 aa overlap); etc. Q7TXX8 No intermediary metabolism and respiration Rv2765 NC_002945.3 Mycobrowser_v2 CDS 3032162 3032944 . - 0 Mb2788c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb2788c, -, len: 260 aa. Equivalent to Rv2766c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to others (from bacteria and eukaryota) e.g. Q9K3Y8|2SCG61.27c PUTATIVE SHORT CHAIN OXIDOREDUCTASE from Streptomyces coelicolor (253 aa), FASTA scores: opt: 722, E(): 7.4e-39,(44.75% identity in 248 aa overlap); Q93790|F54F3.4 HYPOTHETICAL SDR PROTEIN from Caenorhabditis elegans (260 aa), FASTA scores: opt: 613, E(): 6.9e-32, (41.7% identity in 247 aa overlap); O95162|O95162|SCAD-SRL PEROXISOMAL SHORT-CHAIN ALCOHOL DEHYDROGENASE from Homo sapiens (Human) (260 aa), FASTA scores: opt: 594, E(): 1.1e-30,(39.6% identity in 250 aa overlap); P51831|FABG_BACSU 3-OXOACYL-[ACYL-CARRIER PROTEIN] from Bacillus subtilis (246 aa), FASTA scores: opt: 504, E(): 4e-28, (37.2% identity in 247 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis acyl-carrier proteins e.g. MTCY03C7.07 (38.5% identity in 244 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Note that previously known as fabG5, a 3-oxoacyl-[acyl-carrier-protein]. Q7TXX7 No intermediary metabolism and respiration Rv2766c NC_002945.3 Mycobrowser_v2 CDS 3032941 3033294 . - 0 Mb2789c POSSIBLE MEMBRANE PROTEIN Mb2789c, -, len: 117 aa. Equivalent to Rv2767c,len: 117 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 117 aa overlap). Possible membrane protein, showing very weak similarity with Q9L2H7|SCC121.09 PUTATIVE METAL TRANSPORT ABC TRANSPORTER from Streptomyces coelicolor (256 aa), FASTA scores: opt: 110, E(): 1, (33.05% identity in 112 aa overlap). Questionable ORF. Q7TXX6 No cell wall and cell processes Rv2767c NC_002945.3 Mycobrowser_v2 CDS 3073370 3074050 . + 0 Mb2835 PUTATIVE TRANSPOSASE [FIRST PART] Mb2835, -, len: 226 aa. Similar to 5' end of Rv2812, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (92.4% identity in 224 aa overlap). Putative transposase for IS1604, similar to putative transposases and hypothetical proteins e.g. Q9EZM2|PUTATIVE TRANSPOSASE from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 329, E(): 3e-13, (27.05% identity in 362 aa overlap); CAC46499 PUTATIVE TRANSPOSASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (390 aa),FASTA scores: opt: 327, E(): 3.9e-13, (30.5% identity in 367 aa overlap); etc. Contains possible helix-turn-helix motif at aa 50-71 (Score 1140, +3.07 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (tg-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Q7TXT4 No NC_002945.3 Mycobrowser_v2 CDS 3033468 3034652 . - 0 Mb2790c PPE43 ppe family protein ppe43 Mb2790c, PPE43, len: 394 aa. Equivalent to Rv2768c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 394 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. upstream ORF O33312|Rv2770c|MTV002.35c (402 aa),FASTA scores: opt: 1135, E(): 6.1e-51, (62.15% identity in 391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from M. tuberculosis (391 aa), FASTA scores: opt: 1721, E(): 6.8e-81, (70.35% identity in 398 aa overlap). Equivalent to AAK47157 from Mycobacterium tuberculosis strain CDC1551 (462 aa) but shorter 68 aa. Q7TXX5 No NC_002945.3 Mycobrowser_v2 CDS 3039948 3040877 . - 0 Mb2798c PROBABLE OXIDOREDUCTASE Mb2798c, -, len: 309 aa. Equivalent to Rv2776c,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to other oxidoreductases e.g. Q9KZ15|SC10B7.17 PUTATIVE IRON-SULFUR OXIDOREDUCTASE from Streptomyces coelicolor (364 aa),FASTA scores: opt: 846, E(): 1.2e-45, (46.75% identity in 308 aa overlap); O88034|SC5A7.28c IRON-SULFUR OXIDOREDUCTASE BETA SUBUNIT from Streptomyces coelicolor (313 aa), FASTA scores: opt: 745, E(): 2.3e-39, (41.45% identity in 316 aa overlap); P33164|PDR_BURCE|OPHA1 PHTHALATE DIOXYGENASE REDUCTASE from Burkholderia cepacia (Pseudomonas cepacia) (321 aa), FASTA scores: opt: 616,E(): 2.9e-31, (33.65% identity in 309 aa overlap); etc. Equivalent to AAK47165 from Mycobacterium tuberculosis strain CDC1551 (363 aa) but shorter 54 aa. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00063 Aldo/keto reductase family putative active site signature. SEEMS TO BELONG TO THE 2FE2S PLANT-TYPE FERREDOXIN FAMILY IN THE C-TERMINAL SECTION. Q7TXW7 No intermediary metabolism and respiration Rv2776c NC_002945.3 Mycobrowser_v2 CDS 3035883 3037031 . - 0 Mb2792c PPE44 ppe family protein ppe44 Mb2792c, PPE44, len: 382 aa. Equivalent to Rv2770c,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 382 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. downstream ORF O33310|Rv2768c|MTV002.33c from M. tuberculosis (394 aa), FASTA scores: opt: 1135, E(): 2.2e-53, (62.15% identity in 391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 1010, E(): 1e-46, (55.95% identity in 395 aa overlap). Equivalent to AAK47159 from M. tuberculosis strain CDC1551 (402 aa) but shorter 20 aa. Start changed since first submission (-20 aa). Q7TXX3 No NC_002945.3 Mycobrowser_v2 CDS 3037155 3037607 . - 0 Mb2793c CONSERVED HYPOTHETICAL PROTEIN Mb2793c, -, len: 150 aa. Equivalent to Rv2771c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Conserved hypothetical protein, equivalent to Q9CBV8|ML1525 HYPOTHETICAL PROTEIN from Mycobacterium leprae (151 aa), FASTA scores: opt: 489, E(): 1.7e-27, (52.7% identity in 148 aa overlap). Also highly similar to Q9RD46|SCF56.21 HYPOTHETICAL 15.7 KDA PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 671, E(): 2.2e-40, (67.8% identity in 146 aa overlap). Q7TXX2 No conserved hypotheticals Rv2771c NC_002945.3 Mycobrowser_v2 CDS 3073980 3074777 . + 0 Mb2836 PUTATIVE TRANSPOSASE [SECOND PART] Mb2836, -, len: 265 aa. Equivalent to 3' end of Rv2812, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (99.623% identity in 265 aa overlap). Putative transposase for IS1604, similar to putative transposases and hypothetical proteins e.g. Q9EZM2|PUTATIVE TRANSPOSASE from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 329, E(): 3e-13, (27.05% identity in 362 aa overlap); CAC46499 PUTATIVE TRANSPOSASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (390 aa), FASTA scores: opt: 327,E(): 3.9e-13, (30.5% identity in 367 aa overlap); etc. Contains possible helix-turn-helix motif at aa 50-71 (Score 1140, +3.07 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (tg-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Q7TXT3 No NC_002945.3 Mycobrowser_v2 CDS 3037693 3038166 . - 0 Mb2794c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb2794c, -, len: 157 aa. Equivalent to Rv2772c,len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 157 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CBV7|ML1526 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 767, E(): 1.5e-43, (76.6% identity in 154 aa overlap); and similar to P46830|YDAB_MYCBO from Mycobacterium bovis (177 aa), FASTA scores: opt: 337, E(): 3.9e-15, (40.75% identity in 135 aa overlap). Also similar to O86837|SC9A10.04 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 338,E(): 3e-15, (43.75% identity in 144 aa overlap). Q7TXX1 No cell wall and cell processes Rv2772c NC_002945.3 Mycobrowser_v2 CDS 3038178 3038915 . - 0 Mb2795c dapB DIHYDRODIPICOLINATE REDUCTASE DAPB (DHPR) Mb2795c, dapB, len: 245 aa. Equivalent to Rv2773c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 245 aa overlap). dapB,dihydrodipicolinate reductase (EC 1.3.1.26) (see first citation below), highly similar to many e.g. P40110|DAPB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (248 aa), FASTA scores: opt: 1030,E(): 1.8e-58, (65.45% identity in 246 aa overlap); O86836|DAPB_STRCO|SC9A10.03 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 997, E(): 2.3e-56, (61.15% identity in 247 aa overlap); P42976|DAPB_BACSU from Bacillus subtilis (267 aa), FASTA scores: opt: 608, E(): 1.7e-31, (45.95% identity in 209 aa overlap); P46829|DAPB_MYCBO from Mycobacterium bovis (see second citation below) (271 aa), FASTA scores: opt: 505, E(): 6.3e-25, (36.2% identity in 246 aa overlap); etc. BELONGS TO THE DIHYDRODIPICOLINATE REDUCTASE FAMILY. X2BLH0,Q7TXX0 No NC_002945.3 Mycobrowser_v2 CDS 3038926 3039330 . - 0 Mb2796c HYPOTHETICAL PROTEIN Mb2796c, -, len: 134 aa. Equivalent to Rv2774c,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Hypothetical unknown protein. Q7TXW9 No conserved hypotheticals Rv2774c NC_002945.3 Mycobrowser_v2 CDS 3039483 3039944 . + 0 Mb2797 gcn5-related n-acetyltransferase Mb2797, -, len: 153 aa. Equivalent to Rv2775, len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Hypothetical unknown protein, showing weak similarity with hypothetical proteins e.g. Q9ZBJ7|SC9C7.13c from Streptomyces coelicolor (179 aa), FASTA scores: opt: 167, E(): 0.00024,(29.05% identity in 148 aa overlap). Equivalent to AAK47164 from Mycobacterium tuberculosis strain CDC1551 (185 aa) but shorter 32 aa. Q7TXW8 No intermediary metabolism and respiration Rv2775 NC_002945.3 Mycobrowser_v2 CDS 3041059 3042129 . - 0 Mb2799c CONSERVED HYPOTHETICAL PROTEIN Mb2799c, -, len: 356 aa. Equivalent to Rv2777c,len: 356 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Conserved hypothetical protein, highly similar (but longer in N-terminus) to hypothetical proteins Q9KZ16|SC10B7.16 from Streptomyces coelicolor (296 aa), FASTA scores: opt: 980,E(): 6.8e-57, (51.25% identity in 281 aa overlap); and Q9HYS0|PA3325 from Pseudomonas aeruginosa (295 aa), FASTA scores: opt: 816, E(): 4e-46, (43.75% identity in 288 aa overlap); and similar (but longer in N-terminus) to other hypothetical proteins e.g. Q9I3H1|PA1542 from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 234, E(): 6.3e-08,(31.8% identity in 258 aa overlap). Equivalent to AAK47166 from Mycobacterium tuberculosis strain CDC1551 (393 aa) but shorter 37 aa. Q7TXW6 No conserved hypotheticals Rv2777c NC_002945.3 Mycobrowser_v2 CDS 4330558 4334112 . + 0 Mb3940 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3940, -, len: 1184 aa. Equivalent to Rv3910, len: 1184 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1184 aa overlap). Probable conserved transmembrane protein (hydrophobic domain ~50-550),equivalent to Q9CCX9|ML2700 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (1206 aa), FASTA scores: opt: 5554, E(): 0, (75.15% identity in 1182 aa overlap); and highly similar, but shorter 380 aa, to Q50199|L222-ORF10 from Mycobacterium leprae (784 aa) FASTA scores: opt: 3297, E(): 5.5e-170, (68.8% identity in 769 aa overlap); and at the N-terminal end with Q50198|L222-ORF also from Mycobacterium leprae (379 aa) FASTA scores: opt: 1955, E(): 5.7e-98, (88.4% identity in 353 aa overlap) (ORFs 9 and 10 are adjacent on L222). Also similar in part (principally at the N-terminal end) to other membrane proteins e.g. Q9X8T0|SCH24.16c PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (811 aa), FASTA scores: opt: 573, E(): 2.8e-23, (31.05% identity in 573 aa overlap); O05467|MVIN_RHITR INTEGRAL MEMBRANE PROTEIN VIRULENCE FACTOR MVIN HOMOLOG from Rhizobium tropici (533 aa), FASTA scores: opt: 468, E(): 9e-18, (27.1% identity in 524 aa overlap); P56882|MVIN_RHIME INTEGRAL MEMBRANE PROTEIN VIRULENCE FACTOR MVIN HOMOLOG from Rhizobium meliloti (Sinorhizobium meliloti) (535 aa), FASTA scores: opt: 453, E(): 5.8e-17,(26.2% identity in 557 aa overlap); etc. Q7TVD1 No cell wall and cell processes Rv3910 NC_002945.3 Mycobrowser_v2 CDS 3042287 3042757 . - 0 Mb2800c conserved protein Mb2800c, -, len: 156 aa. Equivalent to Rv2778c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, similar to Q9CBF7|ML2031 HYPOTHETICAL PROTEIN from Mycobacterium leprae (151 aa),FASTA scores: opt: 227, E(): 8.5e-09, (35.95% identity in 153 aa overlap). Also similar to AAK46204|MT1931.1 HYPOTHETICAL 17.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (158 aa), FASTA scores: opt: 238, E(): 1.5e-09, (35.75% identity in 151 aa overlap); or O07748|Rv1883c|MTCY180.35 HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (158 aa),FASTA scores: opt: 212, E(): 9.7e-08, (34.45% identity in 151 aa overlap); note that AAK46204|MT1931.1 and O07748|Rv1883c|MTCY180.35 are essentially the same protein except for a small (5 aa) gap. Q7TXW5 No conserved hypotheticals Rv2778c NC_002945.3 Mycobrowser_v2 CDS 3042789 3043304 . - 0 Mb2801c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LRP/ASNC-FAMILY) Mb2801c, -, len: 171 aa. Equivalent to Rv2779c,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(94.475% identity in 179 aa overlap). Possible transcriptional regulator, from the Lrp/AsnC family,similar (but longer ~30 aa in N-terminus) to others e.g. CAC42842|SCBAC36F5.06 PUTATIVE ASNC-FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (163 aa),FASTA scores: opt: 333, E(): 4.4e-16, (39.7% identity in 141 aa overlap); O07920|AZLB_BACSU TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Bacillus subtilis; Q9I233|PA2082 PROBABLE TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 322, E(): 2.5e-15, (33.1% identity in 148 aa overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (33.3% identity in 120 aa overlap). Equivalent to AAK47168 from Mycobacterium tuberculosis strain CDC1551 (181 aa). SEEMS TO BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS. Start changed since first submission (+8 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa). Q7TXW4 No regulatory proteins Rv2779c NC_002945.3 Mycobrowser_v2 CDS 3043370 3043768 . + 0 Mb2802 alda SECRETED L-ALANINE DEHYDROGENASE ALDa [FIRST PART] (40 KDA ANTIGEN) (TB43) Mb2802, alda, len: 132 aa. Similar to 5' end of Rv2780, len: 371 aa, from Mycobacterium tuberculosis strain H37Rv, (98.9% identity in 89 aa overlap). ald,secreted L-alanine dehydrogenase (EC 1.4.1.1) (40 kd antigen) (see first citations below); equivalent to Q9CBV6|ALD|ML1532 L-ALANINE DEHYDROGENASE from Mycobacterium leprae (371 aa), FASTA scores: opt: 2081,E(): 4e-115, (85.45% identity in 371 aa overlap). Also highly similar to others e.g. Q9S227|SCI51.13c from Streptomyces coelicolor (371 aa), FASTA scores: opt: 1575,E(): 2.3e-85, (66.05% identity in 371 aa overlap); Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372 aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans (390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2% identity in 371 aa overlap); etc. Contains PS00836 and PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 and 2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, alda and aldb. Q7TXW3 No NC_002945.3 Mycobrowser_v2 CDS 3043765 3044484 . + 0 Mb2803 aldb SECRETED L-ALANINE DEHYDROGENASE ALDb [SECOND PART] (40 KDA ANTIGEN) (TB43) Mb2803, aldb, len: 239 aa. Equivalent to 3' end of Rv2780, len: 371 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 239 aa overlap). ald,secreted L-alanine dehydrogenase (EC 1.4.1.1) (40 kd antigen) (see first citations below); equivalent to Q9CBV6|ALD|ML1532 L-ALANINE DEHYDROGENASE from Mycobacterium leprae (371 aa), FASTA scores: opt: 2081,E(): 4e-115, (85.45% identity in 371 aa overlap). Also highly similar to others e.g. Q9S227|SCI51.13c from Streptomyces coelicolor (371 aa), FASTA scores: opt: 1575,E(): 2.3e-85, (66.05% identity in 371 aa overlap); Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372 aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans (390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2% identity in 371 aa overlap); etc. Contains PS00836 and PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 and 2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, alda and aldb. Q7TXW2 No NC_002945.3 Mycobrowser_v2 CDS 3050454 3051449 . - 0 Mb2809c ribF probable bifunctional fad synthetase/riboflavin biosynthesis protein ribf: riboflavin kinase (flavokinase) + fmn adenylyltransferase (fad pyrophosphorylase) (fad synthetase)(fad diphosphorylase) (flavin adenine dinucleotide synthetase) Mb2809c, ribF, len: 331 aa. Equivalent to Rv2786c,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 331 aa overlap). Probable ribF, FAD synthetase/riboflavin biosynthesis protein, bifunctional enzyme (EC 2.7.1.26; 2.7.7.2), equivalent to O32968|RIBF|ML0852 RIBOFLAVIN KINASE from Mycobacterium leprae (331 aa), FASTA scores: opt: 1923, E(): 2.3e-115,(87.45% identity in 327 aa overlap). Also highly similar to many e.g. Q59263|RIBF_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (338 aa), FASTA scores: opt: 899, E(): 5.7e-50, (45.8% identity in 321 aa overlap); Q9Z530|SC9F2.05c from Streptomyces coelicolor (318 aa), FASTA scores: opt: 862, E(): 1.3e-47, (52.45% identity in 324 aa overlap); P08391|RIBF_ECOLI|B0025|Z0029ECS0028 from Escherichia coli strains K12 and O157:H7 (313 aa), FASTA scores: opt: 517, E(): 1.3e-25, (36.05% identity in 305 aa overlap); etc. Q7TXV8 No NC_002945.3 Mycobrowser_v2 CDS 3044499 3045533 . - 0 Mb2804c POSSIBLE ALANINE RICH OXIDOREDUCTASE Mb2804c, -, len: 344 aa. Equivalent to Rv2781c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Possible ala-rich oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases or hypothetical proteins e.g. Q9RDD8|SCC77.20c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (364 aa), FASTA scores: opt: 912, E(): 5.3e-47,(45.55% identity in 336 aa overlap); Q9FDD4|2-NPDL PUTATIVE 2-NITROPROPANE DIOXYGENASE from Streptomyces ansochromogenes (363 aa), FASTA scores: opt: 869, E(): 1.9e-44, (44.2% identity in 337 aa overlap); O05413|YRPB 2-NITROPROPANE DIOXYGENASE from Bacillus subtilis (347 aa), FASTA scores: opt: 560, E(): 4.9e-26, (33.75% identity in 317 aa overlap); etc. Q7TXW1 No intermediary metabolism and respiration Rv2781c NC_002945.3 Mycobrowser_v2 CDS 3045594 3046910 . - 0 Mb2805c pepR PROBABLE ZINC PROTEASE PEPR Mb2805c, pepR, len: 438 aa. Equivalent to Rv2782c,len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Probable pepR,protease/peptidase (EC 3.4.99.-), equivalent to O32965|YR82_MYCLE|ML0855|MLCB22.26c HYPOTHETICAL ZINC PROTEASE from Mycobacterium leprae (445 aa), FASTA scores: opt: 2346, E(): 4.3e-146, (84.3% identity in 421 aa overlap). Also highly similar to others e.g. O86835|YA12_STRCO|SC9A10.02 from Streptomyces coelicolor (459 aa), FASTA scores: opt: 1394, E(): 1.1e-83, (51.9% identity in 416 aa overlap); Q04805|YMXG_BACSU|YMXG from Bacillus subtilis (409 aa), FASTA scores: opt: 1014, E(): 7.9e-59, (37.55% identity in 410 aa overlap); Q9KA85|BH2405 from Bacillus halodurans (413 aa), FASTA scores: opt: 967, E(): 9.6e-56, (38.6% identity in 417 aa overlap); etc. Contains PS00143 Insulinase family,zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M16, ALSO KNOWN AS THE INSULINASE FAMILY. COFACTOR: REQUIRES DIVALENT CATIONS FOR ACTIVITY. BINDS ZINC. X2BLH9,P0A5S9 No NC_002945.3 Mycobrowser_v2 CDS 3046888 3049146 . - 0 Mb2806c gpsI BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (POLYNUCLEOTIDE PHOSPHORYLASE) (PNPASE) Mb2806c, gpsI, len: 752 aa. Equivalent to Rv2783c,len: 752 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 752 aa overlap). Probable gpsI,polyribonucleotide nucleotidyltransferase (EC 2.7.7.8; 2.7.6.-), equivalent to Q9CCF8|GPSI|ML0854 (alias O32966) PUTATIVE POLYRIBONUCLEOTIDE PHOSPHORYLASE / GUANOSINE PENTAPHOSPHATE SYNTHETASE from Mycobacterium leprae (773 aa), FASTA scores: opt: 4304, E(): 0, (89.95% identity in 757 aa overlap). Also highly similar to others e.g. O86656|GPSI GUANOSINE PENTAPHOSPHATE SYNTHETASE/ POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (FRAGMENT) from Streptomyces coelicolor (716 aa), FASTA scores: opt: 3393,E(): 5.8e-192, (72.77% identity in 718 aa overlap); Q53597|GPSI GUANOSINE PENTAPHOSPHATE SYNTHETASE from Streptomyces antibioticus (740 aa), FASTA scores: opt: 3314, E(): 2.6e-187, (70.55% identity in 733 aa overlap); P72659|PNP|SLL1043 POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE from Synechocystis sp. strain PCC 6803 (718 aa), FASTA scores: opt: 1244, E(): 1.7e-65,(45.05% identity in 750 aa overlap); etc. Note that S. antibioticus guanosine pentaphosphate synthetase is a multifunctional enzyme that also acts as a polyribonucleotide nucleotidyltransferase. Start site chosen by homology from several alternatives. X2BLY3,Q7TXW0 No NC_002945.3 Mycobrowser_v2 CDS 3049500 3050015 . - 0 Mb2807c lppU PROBABLE LIPOPROTEIN LPPU Mb2807c, lppU, len: 171 aa. Equivalent to Rv2784c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Probable lppU,lipoprotein, sharing no homology with other proteins. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TXV9 No NC_002945.3 Mycobrowser_v2 CDS 3050028 3050297 . - 0 Mb2808c rpsO 30s ribosomal protein s15 rpso Mb2808c, rpsO, len: 89 aa. Equivalent to Rv2785c,len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Probable rpsO, 30s ribosomal protein S15, equivalent to O32967|RS15_MYCLE|RPSO|ML0853|MLCB22.28c 30S RIBOSOMAL PROTEIN S15 from Mycobacterium leprae (89 aa), FASTA scores: opt: 522, E(): 7.4e-34, (92.15% identity in 89 aa overlap). Also highly similar to many e.g. O86655|RS15_STRCO|RPSO|SC3C3.22 from Streptomyces coelicolor (95 aa), FASTA scores: opt: 408, E(): 6.7e-25,(62.9% identity in 89 aa overlap); P05766|RS15_BACST|RPSO from Bacillus stearothermophilus (88 aa), FASTA scores: opt: 385, E(): 4e-23, (62.5% identity in 88 aa overlap); P21473|RS15_BACSU|RPSO from Bacillus subtilis (88 aa),FASTA scores: opt: 351, E(): 1.9e-20, (57.95% identity in 88 aa overlap); P02371|RS15_ECOLI|RPSO|SEC|B3165 from Escherichia coli strain K12 (88 aa), FASTA scores: opt: 295, E(): 4.5e-22, (52.3% identity in 88 aa overlap); etc. Contains PS00362 Ribosomal protein S15 signature. BELONGS TO THE S15P FAMILY OF RIBOSOMAL PROTEINS. X2BLL1,P66430 No NC_002945.3 Mycobrowser_v2 CDS 3053508 3054194 . + 0 Mb2811 sirR PROBABLE TRANSCRIPTIONAL REPRESSOR SIRR Mb2811, sirR, len: 228 aa. Equivalent to Rv2788,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 228 aa overlap). Probable sirR,transcriptional repressor, highly similar to others e.g. Q9RRF3|DR2539 PUTATIVE IRON DEPENDENT REPRESSOR from Deinococcus radiodurans (232 aa), FASTA scores: opt: 518,E(): 4.5e-26, (41.2% identity in 221 aa overlap); Q9HRU8|SIRR|VNG0536G from Halobacterium sp. strain NRC-1 (233 aa), FASTA scores: opt: 516, E(): 6.1e-26, (40.45% identity in 220 aa overlap); Q9KIJ2|SLOR REGULATOR SLOR from Streptococcus mutans (217 aa), FASTA scores: opt: 418, E(): 1.2e-19, (36.15% identity in 213 aa overlap); etc. Also some similarity to Q50495|IDER_MYCTU|MTCY05A6.32|IDER|DTXR|Rv2711|MT2784|MTCY 05A6.32 IRON-DEPENDENT REPRESSOR from Mycobacterium tuberculosis (230 aa), FASTA scores: opt: 266, E(): 7.1e-10, (27.6% identity in 221 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1327, +3.71 SD). COULD BELONG TO THE CRP/FNR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TXV6 No regulatory proteins Rv2788 NC_002945.3 Mycobrowser_v2 CDS 3594472 3594741 . - 0 Mb3288c whiB2 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB2 Mb3288c, whiB2, len: 89 aa. Equivalent to Rv3260c,len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Probable whiB2,WhiB-like regulatory protein (see first citation below),similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q9CCK0|WHIB2|ML0760 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (89 aa), FASTA scores: opt: 550, E(): 6.1e-31,(85.4% identity in 89 aa overlap). Also similar to others e.g. Q9S426 WHMD REGULATORY PROTEIN (see second citation below) from Mycobacterium smegmatis (129 aa), FASTA scores: opt: 488, E(): 1.4e-26, (83.55% identity in 85 aa overlap); Q06387|WHIB-STV WHIB-STV PROTEIN from Streptomyces griseocarneus (87 aa), FASTA scores: opt: 443, E(): 1.2e-23, (74.7% identity in 83 aa overlap); Q05429|WHIB|WHIB1 TRANSCRIPTION-LIKE FACTOR WHIB from Streptomyces aureofaciens (87 aa), FASTA scores: opt: 442,E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc. Equivalent to AAK47700 WhiB-related protein from Mycobacterium tuberculosis strain CDC1551 (123 aa) but shorter 34 aa. Also similar to other Mycobacterium tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71 aa overlap) and MTCY78.13c (37.4% identity in 91 aa overlap). Start chosen by homology but ORF continues to ATG upstream at 3754. Q7TWV5 No NC_002945.3 Mycobrowser_v2 CDS 3054255 3055487 . - 0 Mb2812c fadE21 PROBABLE ACYL-CoA DEHYDROGENASE FADE21 Mb2812c, fadE21, len: 410 aa. Equivalent to Rv2789c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 410 aa overlap). Probable fadE21, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 689, E(): 9.3e-37,(35.75% identity in 400 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 679,E(): 4.1e-36, (37.3% identity in 405 aa overlap); Q06319|ACDS_MEGEL from Megasphaera elsdenii (383 aa),FASTA scores: opt: 650, E(): 3e-34, (37.7% identity in 334 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 1 (PS00072). BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TXV5 No lipid metabolism Rv2789c NC_002945.3 Mycobrowser_v2 CDS 3055513 3056718 . - 0 Mb2813c ltp1 PROBABLE LIPID-TRANSFER PROTEIN LTP1 Mb2813c, ltp1, len: 401 aa. Equivalent to Rv2790c,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Probable ltp1,lipid-transfer protein, highly similar to many eukaryotic sterol-carrier proteins/lipid-transfer protein precursors (see first citation below) e.g. O62742|SCP2 STEROL CARRIER PROTEIN X from Oryctolagus cuniculus (Rabbit) (547 aa),FASTA scores: opt: 1710, E(): 6e-102, (63.7% identity in 394 aa overlap); Q9QW19 3-OXOACYL-CoA THIOLASE HOMOLOG (FRAGMENT) (see citation below) from Rattus sp. (405 aa),FASTA scores: opt: 1696, E(): 3.8e-101, (63.2% identity in 394 aa overlap); P11915|NLTP_RAT|SCP2|SCP-2 NONSPECIFIC LIPID-TRANSFER PROTEIN PRECURSOR from Rattus norvegicus (Rat) (547 aa), FASTA scores: opt: 1696, E(): 4.8e-101,(63.2% identity in 394 aa overlap); P32020|NLTP_MOUSE|SCP2|SCP-2 NONSPECIFIC LIPID-TRANSFER PROTEIN PRECURSOR from Mus musculus (Mouse) (547 aa),FASTA scores: opt: 1681, E(): 4.3e-100, (62.7% identity in 394 aa overlap); etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature and PS00737 Thiolases signature 2. Also similar to other M. tuberculosis proteins e.g. O06144|Rv1627c|MTCY01B2.19c (402 aa) (35.8% identity in 413 aa overlap). Q7TXV4 No NC_002945.3 Mycobrowser_v2 CDS 3056751 3058130 . - 0 Mb2814c PROBABLE TRANSPOSASE Mb2814c, -, len: 459 aa. Equivalent to Rv2791c,len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable IS1602 transposase for IS1602 element, similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa), FASTA scores: opt: 2718, E(): 6.3e-165, (86.05% identity in 459 aa overlap). Q7TXV3 No insertion seqs and phages Rv2791c NC_002945.3 Mycobrowser_v2 CDS 3058913 3059809 . - 0 Mb2816c truB PROBABLE TRNA PSEUDOURIDINE SYNTHASE B TRUB (TRNA PSEUDOURIDINE 55 SYNTHASE) (PSI55 SYNTHASE) (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE) Mb2816c, truB, len: 298 aa. Equivalent to Rv2793c,len: 298 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 298 aa overlap). Probable truB, tRNA pseudouridine synthase (EC 4.2.1.70), equivalent to Q9Z5I4|TRUB_MYCLE|ML1546 OR MLCB596.24 TRNA PSEUDOURIDINE SYNTHASE B from Mycobacterium leprae (320 aa), FASTA scores: opt: 1403, E(): 2.9e-83, (74.05% identity in 293 aa overlap). Also highly similar to many e.g. Q9Z528|TRUB_STRCO|SC9F2.07c from Streptomyces coelicolor (301 aa), FASTA scores: opt: 870, E(): 7.6e-49, (50.7% identity in 296 aa overlap); P09171|TRUB_ECOLI|P35|B3166|Z4527|ECS4047 from Escherichia coli strains K12 and O157:H7 (314 aa), FASTA scores: opt: 574, E(): 1e-29, (42.5% identity in 214 aa overlap); Q9PGR1|TRUB_XYLFA|XF0237 from Xylella fastidiosa (302 aa),FASTA scores: opt: 569, E(): 2.1e-29, (41.05% identity in 285 aa overlap); etc. BELONGS TO THE TRUB FAMILY OF PSEUDOURIDINE SYNTHASES. X2BLZ2,P62189 No NC_002945.3 Mycobrowser_v2 CDS 3059806 3060489 . - 0 Mb2817c pptt phosphopantetheinyl transferase pptt (coa:apo-[acp]pantetheinephosphotransferase) (coa:apo-[acyl-carrier protein]pantetheinephosphotransferase) Mb2817c, -, len: 227 aa. Equivalent to Rv2794c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 227 aa overlap). Conserved hypothetical protein, equivalent to Q9Z5I5|ML1547|MLCB596.23 PUTATIVE IRON-CHELATING COMPLEX SUBUNIT from Mycobacterium leprae (227 aa), FASTA scores: opt: 1248, E(): 9.1e-77, (79.75% identity in 227 aa overlap). Also highly similar to various proteins e.g. Q9F0Q6|PPTA PHOSPHOPANTETHEINYL TRANSFERASE from Streptomyces verticillus (246 aa), FASTA scores: opt: 692, E(): 2.8e-39, (46.65% identity in 225 aa overlap); O88029|SC5A7.23 HYPOTHETICAL 24.5 KDA PROTEIN from Streptomyces coelicolor (226 aa), FASTA scores: opt: 679, E(): 2e-38, (46.9% identity in 226 aa overlap); O24813 DNA FOR L-PROLINE 3-HYDROXYLASE from Streptomyces sp. (208 aa), FASTA scores: opt: 631, E(): 3.2e-35, (48.1% identity in 208 aa overlap); etc. Q7TXV1 No lipid metabolism Rv2794c NC_002945.3 Mycobrowser_v2 CDS 3060486 3061460 . - 0 Mb2818c CONSERVED HYPOTHETICAL PROTEIN Mb2818c, -, len: 324 aa. Equivalent to Rv2795c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Conserved hypothetical protein, equivalent to Q9Z5I6|ML1548|MLCB596.22 HYPOTHETICAL 37.5 KDA PROTEIN from Mycobacterium leprae (321 aa), FASTA scores: opt: 2018, E(): 6.3e-128, (87.4% identity in 318 aa overlap). Also highly similar to O88028|SC5A7.22 HYPOTHETICAL 33.5 KDA PROTEIN from Streptomyces coelicolor (295 aa), FASTA scores: opt: 1202, E(): 3.4e-73, (57.2% identity in 285 aa overlap); and Q9AMH7|SIMX4 SIMX4 PROTEIN from Streptomyces antibioticus (293 aa), FASTA scores: opt: 1045, E(): 1.2e-62, (51.4% identity in 286 aa overlap). C-terminus highly similar to Q9F0Q7 HYPOTHETICAL 9.6 KDA PROTEIN (FRAGMENT) from Streptomyces verticillus (81 aa), FASTA scores: opt: 395, E(): 1.8e-19, (68.35% identity in 79 aa overlap). Also similar to other proteins e.g. Q9FWV7 HYPOTHETICAL 45.3 KDA PROTEIN from Oryza sativa (Rice) (402 aa), FASTA scores: opt: 294, E(): 3.6e-12, (26.45% identity in 340 aa overlap). Q7TXV0 No conserved hypotheticals Rv2795c NC_002945.3 Mycobrowser_v2 CDS 3061605 3062168 . - 0 Mb2819c lppV PROBABLE CONSERVED LIPOPROTEIN LPPV Mb2819c, lppV, len: 187 aa. Equivalent to Rv2796c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Probable lppV,conserved lipoprotein, similar to others from Mycobacterium tuberculosis e.g. P95009|LPPB|Rv2544|MTCY159.12c PROBABLE CONSERVED LIPOPROTEIN (220 aa), FASTA scores: opt: 168, E(): 0.00066, (22.45% identity in 196 aa overlap); and P95010|LPPA|RV2543|MTCY159.13c PROBABLE CONSERVED LIPOPROTEIN (219 aa), FASTA scores: opt: 165, E(): 0.001,(23.1% identity in 199 aa overlap). Q7TXU9 No NC_002945.3 Mycobrowser_v2 CDS 3062168 3063856 . - 0 Mb2820c CONSERVED HYPOTHETICAL PROTEIN Mb2820c, -, len: 562 aa. Equivalent to Rv2797c,len: 562 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 562 aa overlap). Conserved hypothetical ala-rich protein. C-terminus highly similar to several mycobacterial proteins e.g. AAK46927|MT2616 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa), FASTA scores: opt: 535, E(): 4.6e-22, (42.95% identity in 263 aa overlap); P95011|Rv2542|MTCY159.14c HYPOTHETICAL 42.4 KDA PROTEIN from Mycobacterium tuberculosis (403 aa), FASTA scores: opt: 537, E(): 5e-22, (40.75% identity in 292 aa overlap) (similarity in the second half of protein); P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 HYPOTHETICAL 28.1 KDA PROTEIN (266 aa), FASTA scores: opt: 314, E(): 5.7e-10, (39.0% identity in 254 aa overlap); etc. Contains PS00120 Lipases, serine active site. Q7TXU8 No conserved hypotheticals Rv2797c NC_002945.3 Mycobrowser_v2 CDS 3063860 3064186 . - 0 Mb2821c CONSERVED HYPOTHETICAL PROTEIN Mb2821c, -, len: 108 aa. Equivalent to Rv2798c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Conserved hypothetical ala-rich protein, similar to P71545|Y965_MYCTU|Rv0965c|MT0993|MTCY10D7.09 HYPOTHETICAL 14.5 KDA PROTEIN from Mycobacterium tuberculosis (139 aa),FASTA scores: opt: 198, E(): 8e-07, (38.9% identity in 90 aa overlap). Q7TXU7 No conserved hypotheticals Rv2798c NC_002945.3 Mycobrowser_v2 CDS 3068374 3068841 . + 0 Mb2826 CONSERVED HYPOTHETICAL PROTEIN Mb2826, -, len: 155 aa. Equivalent to Rv2803, len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 155 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from other organisms, and with some similarity to C-terminal part of Rv0918|Z95210_12 hypothetical protein from Mycobacterium tuberculosis (158 aa), FASTA scores: opt: 204, E(): 9e-07, (42.35% identity in 85 aa overlap). Replaces original 2803c on other strand. Q7TXU2 No conserved hypotheticals Rv2803 NC_002945.3 Mycobrowser_v2 CDS 3064968 3066617 . + 0 Mb2823 POSSIBLE HYDROLASE Mb2823, -, len: 549 aa. Equivalent to Rv2800, len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 549 aa overlap). Possible hydrolase (EC 3.-.-.-), an esterase (EC 3.1.1.-) or an acylase (EC 3.-.-.-). Similar, but longer in N-terminus, to esterases or acylases e.g. Q9L9D7|COCE COCAINE ESTERASE from Rhodococcus sp. MB1 'Bresler 1999' (574 aa), FASTA scores: opt: 510, E(): 3.1e-23, (33.6% identity in 571 aa overlap); Q9L3U2|STTE PUTATIVE ACYLASE from Streptomyces rochei (Streptomyces parvullus) (554 aa), FASTA scores: opt: 492, E(): 3.7e-22, (34.45% identity in 569 aa overlap); CAC49652|SMB21424 PUTATIVE ESTERASE OR ACYLASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (578 aa), FASTA scores: opt: 405, E(): 7.1e-17, (34.45% identity in 569 aa overlap); etc. Q7TXU5 No intermediary metabolism and respiration Rv2800 NC_002945.3 Mycobrowser_v2 CDS 3101741 3104443 . - 0 Mb2864c infB PROBABLE TRANSLATION INITIATION FACTOR IF-2 INFB Mb2864c, infB, len: 900 aa. Equivalent to Rv2839c,len: 900 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 900 aa overlap). Probable infB,translation initiation factor IF-2, highly similar, but in part, to Q9Z5I9|IF2_MYCLE|ML1556|MLCB596.14 TRANSLATION INITIATION FACTOR IF-2 from Mycobacterium leprae (924 aa),FASTA scores: opt: 4548, E(): 2.4e-132, (83.6% identity in 933 aa overlap). Also similar in part to others e.g. Q9K3E2|SC5H4.30 from Streptomyces coelicolor (835 aa),FASTA scores: opt: 2559, E(): 1.3e-71, (59.9% identity in 833 aa overlap); P17889|IF2_BACSU|INFB from Bacillus subtilis (716 aa), FASTA scores: opt: 1782, E(): 6.6e-48,(46.65% identity in 686 aa overlap); P02995|IF2_ECOLI|INFB|SSYG|B3168|Z4529|ECS4049 from Escherichia coli strains O157:H7 and K12 (890 aa), FASTA scores: opt: 1708, E(): 1.3e-45, (46.2% identity in 662 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE IF-2 FAMILY. X2BM52,P65132 No NC_002945.3 Mycobrowser_v2 CDS 3066719 3067075 . - 0 Mb2824c mazf9 toxin mazf9 Mb2824c, -, len: 118 aa. Equivalent to Rv2801c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein, highly similar to Q9RWK4|DR0662 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (115 aa), FASTA scores: opt: 306, E(): 2e-15,(43.95% identity in 116 aa overlap); and similar to AAK78474|CAC0494 PEMK FAMILY OF DNA-BINDING PROTEINS from Clostridium acetobutylicum (122 aa), FASTA scores: opt: 217, E(): 7.3e-09, (33.35% identity in 117 aa overlap); P96622|YDCE YDCE PROTEIN from Bacillus subtilis (116 aa),FASTA scores: opt: 194, E(): 3.5e-07, (33.35% identity in 117 aa overlap); Q9PHH8|XFA0027 PLASMID MAINTENANCE PROTEIN from Xylella fastidiosa (108 aa), FASTA scores: opt: 188, E(): 9.1e-07, (40.85% identity in 115 aa overlap); etc. Also similar to Q10867|YJ91_MYCTU|Rv1991c|MT2046|MTCY39.28 HYPOTHETICAL 12.3 KDA PROTEIN from Mycobacterium tuberculosis (114 aa),FASTA scores: opt: 190, E(): 6.8e-07, (36.75% identity in 117 aa overlap). Q7TXU4 No virulence, detoxification, adaptation Rv2801c NC_002945.3 Mycobrowser_v2 CDS 3067059 3067289 . - 0 Mb2824A mazE9 Possible antitoxin MazE9 Mb2824A, len: 76 aa. Equivalent to Rv2801A len: 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 76 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazE9,antitoxin, part of toxin-antitoxin (TA) operon with Rv2801c (See Pandey and Gerdes, 2005; Zhu et al., 2006). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). X2BLJ6 No virulence, detoxification, adaptation Rv2801A NC_002945.3 Mycobrowser_v2 CDS 3067332 3068375 . - 0 Mb2825c HYPOTHETICAL ARGININE AND ALANINE RICH PROTEIN Mb2825c, -, len: 347 aa. Equivalent to Rv2802c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Hypothetical unknown arg-, ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 138, E(): 0.12, (37.35% identity in 91 aa overlap); and CAC47718|SMC03294 from Rhizobium meliloti (Sinorhizobium meliloti) (114 aa),FASTA scores: opt: 128, E(): 0.53, (31.4% identity in 86 aa overlap). Equivalent to AAK47191 from Mycobacterium tuberculosis strain CDC1551 (357 aa) but shorter 10 aa. Q7TXU3 No conserved hypotheticals Rv2802c NC_002945.3 Mycobrowser_v2 CDS 3069017 3069646 . - 0 Mb2827c HYPOTHETICAL PROTEIN Mb2827c, -, len: 209 aa. Equivalent to Rv2804c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 209 aa overlap). Hypothetical unknown protein, overlaps neighbouring ORF Rv2805|MTCY16B7.38c. Q7TXU1 No conserved hypotheticals Rv2804c NC_002945.3 Mycobrowser_v2 CDS 3069419 3069823 . + 0 Mb2828 CONSERVED HYPOTHETICAL PROTEIN Mb2828, -, len: 134 aa. Equivalent to Rv2805, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Conserved hypothetical protein, highly similar to N-terminal region of downstream ORF P71644|Rv2807|MTCY16B7.36c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 525, E(): 6.4e-29, (78.2% identity in 101 aa overlap). Also highly similar to N-terminus of other proteins: Q9KK74 HYPOTHETICAL 47.4 KDA PROTEIN from Brevibacterium linens (418 aa), FASTA scores: opt: 480,E(): 8.8e-26, (64.15% identity in 106 aa overlap); AAK40065 Rv3128c-LIKE PROTEIN from Mycobacterium celatum (423 aa), FASTA scores: opt: 218, E(): 1.2e-07, (46.05% identity in 89 aa overlap); Q981U5|MLR9230 from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 131, E(): 0.15, (29.4% identity in 126 aa overlap). Overlaps neighbouring ORF Rv2804c|MTCY16B7.39. Q7TXU0 No conserved hypotheticals Rv2805 NC_002945.3 Mycobrowser_v2 CDS 3070210 3071364 . + 0 Mb2830 CONSERVED HYPOTHETICAL PROTEIN Mb2830, -, len: 384 aa. Equivalent to Rv2807, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 384 aa overlap). Conserved hypothetical protein, highly similar, but shorter 35 aa, to Q9KK74 HYPOTHETICAL 47.4 KDA PROTEIN from Brevibacterium linens (418 aa), FASTA scores: opt: 1865, E(): 9.4e-116, (69.75% identity in 380 aa overlap); and with similarity with other hypothetical proteins or transposases e.g. Q981U5|MLR9230 PROTEIN from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 636,, (36.05% identity in 377 aa overlap); CAC47689 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ISRM18 from Rhizobium meliloti (Sinorhizobium meliloti) (507 aa), FASTA scores: opt: 553,E(): 6.6e-29, (33.5% identity in 370 aa overlap); etc. Also similar to Rv3128c|MTCY164.38c (336 aa) (47.2% identity in 339 aa overlap); and high similarity at N-terminal region with Rv2805|MTCY16B7.38c (79.2% identity in 101 aa overlap). Q7TXT8 No conserved hypotheticals Rv2807 NC_002945.3 Mycobrowser_v2 CDS 3071598 3071855 . + 0 Mb2831 HYPOTHETICAL PROTEIN Mb2831, -, len: 85 aa. Equivalent to Rv2808, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Hypothetical unknown protein. Q7TXT7 No conserved hypotheticals Rv2808 NC_002945.3 Mycobrowser_v2 CDS 3071960 3072271 . + 0 Mb2832 HYPOTHETICAL PROTEIN Mb2832, -, len: 103 aa. Equivalent to Rv2809, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 103 aa overlap). Hypothetical unknown protein. Questionable ORF. Q7TXT6 No conserved hypotheticals Rv2809 NC_002945.3 Mycobrowser_v2 CDS 3072293 3072694 . - 0 Mb2833c PROBABLE TRANSPOSASE Mb2833c, -, len: 133 aa. Equivalent to Rv2810c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable transposase for IS1555, similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA TRANSPOSASE from Arthrobacter sp. TM1 (435 aa), FASTA scores: opt: 294,E(): 1.8e-13, (55.1% identity in 98 aa overlap); Q50440|TNPA INSERTION ELEMENT TNPR AND TNPA GENE from Mycobacterium smegmatis (413 aa), FASTA scores: opt: 274,E(): 4.7e-12, (56.25% identity in 96 aa overlap); etc. No insertion seqs and phages Rv2810c NC_002945.3 Mycobrowser_v2 CDS 3077046 3077882 . - 0 Mb2838c PROBABLE TRANSPOSASE Mb2838c, -, len: 278 aa. Equivalent to Rv2814c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Probable transposase,highly similar to others e.g. P97137|Rv0796|MTV042.06 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS986/IS6110 from Mycobacterium tuberculosis (328 aa),FASTA scores: opt: 2103, E(): 6.1e-132, (100.0% identity in 312 aa overlap); etc. Start unlikely. X2BLY7,P59800 No insertion seqs and phages Rv2814c NC_002945.3 Mycobrowser_v2 CDS 3072691 3073299 . + 0 Mb2834 CONSERVED HYPOTHETICAL PROTEIN Mb2834, -, len: 202 aa. Equivalent to Rv2811, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein. C-terminus equivalent to C-terminus of AAK47198|MT2878 HYPOTHETICAL 17.7 KDA PROTEIN Mycobacterium tuberculosis strain CDC1551 (178 aa), FASTA scores: opt: 609, E(): 1.5e-32, (61.0% identity in 182 aa overlap); and C-terminus highly similar to P72038|Rv3771c|MTCY13D12.05c HYPOTHETICAL 11.3 KDA PROTEIN from Mycobacterium tuberculosis (108 aa), FASTA scores: opt: 465, E(): 2.8e-23, (73.6% identity in 106 aa overlap). Also some similarity with P71962|Rv2665|MTCY441.34 HYPOTHETICAL 10.5 KDA PROTEIN from Mycobacterium tuberculosis (93 aa), FASTA scores: opt: 153, E(): 0.0057, (39.05% identity in 64 aa overlap); and Q9A6W6|CC1966 HYPOTHETICAL PROTEIN CC1966 from Caulobacter crescentus (189 aa), FASTA scores: opt: 115,E(): 2.6, (39.4% identity in 104 aa overlap). Q7TXT5 No conserved hypotheticals Rv2811 NC_002945.3 Mycobrowser_v2 CDS 3074774 3075586 . + 0 Mb2837 CONSERVED HYPOTHETICAL PROTEIN Mb2837, -, len: 270 aa. Equivalent to Rv2813, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 270 aa overlap). Conserved hypothetical protein, similar to various proteins (notably secreted proteins) e.g. Q9ZFL2 HYPOTHETICAL 30.4 KDA PROTEIN from Bacillus stearothermophilus (266 aa), FASTA scores: opt: 518, E(): 1.4e-26, (33.85% identity in 266 aa overlap); P45754|GSPA_AERHY|EXEA GENERAL SECRETION PATHWAY PROTEIN from Aeromonas hydrophila (547 aa), FASTA scores: opt: 386, E(): 1.1e-17, (32.05% identity in 265 aa overlap); Q9KPC7|VC2445 GENERAL SECRETION PATHWAY PROTEIN A from Vibrio cholerae (529 aa), FASTA scores: opt: 366, E(): 2.2e-16, (31.1% identity in 270 aa overlap); Q56674|VC0403 MANNOSE-SENSITIVE HEMAGGLUTININ D from Vibrio cholerae (281 aa), FASTA scores: opt: 317, E(): 2.1e-13, (27.85% identity in 262 aa overlap); etc. Also highly similar to AAK40072 Rv2813-LIKE PROTEIN from Mycobacterium celatum (270 aa), FASTA scores: opt: 1628, E(): 2.8e-99, (90.75% identity in 270 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TXT2 No conserved hypotheticals Rv2813 NC_002945.3 Mycobrowser_v2 CDS 3080187 3080528 . - 0 Mb2840c CONSERVED HYPOTHETICAL PROTEIN Mb2840c, -, len: 113 aa. Equivalent to Rv2816c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Conserved hypothetical protein, highly similar in part to N-terminus of several proteins e.g. O28403|AF1876 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (94 aa),FASTA scores: opt: 137, E(): 0.0022, (47.55% identity in 61 aa overlap); Q97Y85|SSO8090 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (88 aa), FASTA scores: opt: 124,E(): 0.02, (37.3% identity in 59 aa overlap); etc. Q7TXT1 No conserved hypotheticals Rv2816c NC_002945.3 Mycobrowser_v2 CDS 3080529 3081545 . - 0 Mb2841c CONSERVED HYPOTHETICAL PROTEIN Mb2841c, -, len: 338 aa. Equivalent to Rv2817c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 338 aa overlap). Conserved hypothetical protein, showing similarity with O30236|AF2435 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (322 aa), FASTA scores: opt: 397,E(): 2.4e-19, (28.2% identity in 298 aa overlap); Q9KFX9|BH0341 HYPOTHETICAL PROTEIN from Bacillus halodurans (343 aa), FASTA scores: opt: 337, E(): 2.8e-15,(27.35% identity in 300 aa overlap); Q9X2B7|TM1797 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (319 aa), FASTA scores: opt: 321, E(): 3.3e-14, (26.5% identity in 268 aa overlap); etc. Q7TXT0 No conserved hypotheticals Rv2817c NC_002945.3 Mycobrowser_v2 CDS 3081795 3082706 . - 0 Mb2842c hypothetical protein Mb2842c, -, len: 303 aa. Equivalent to 5' end of Rv2818c, len: 382 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 303 aa overlap). Hypothetical unknown protein, equivalent to AAK47210 from Mycobacterium tuberculosis strain CDC1551 (430 aa) but shorter 48 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (303 aa versus 382 aa). Q7TXS9 No NC_002945.3 Mycobrowser_v2 CDS 3082802 3083929 . - 0 Mb2843c HYPOTHETICAL PROTEIN Mb2843c, -, len: 375 aa. Equivalent to Rv2819c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Hypothetical unknown protein (see citations below). Q7TXS8 No conserved hypotheticals Rv2819c NC_002945.3 Mycobrowser_v2 CDS 3097058 3097885 . - 0 Mb2858c ugpE PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPE Mb2858c, ugpE, len: 275 aa. Equivalent to Rv2834c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable ugpE,Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9KDY3|BH1078 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER from Bacillus halodurans (270 aa), FASTA scores: opt: 620, E(): 4.3e-32, (34.7% identity in 268 aa overlap); Q9X0K6|TM1122 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER PERMEASE PROTEIN from Thermotoga maritima (276 aa), FASTA scores: opt: 605, E(): 3.9e-31, (32.5% identity in 274 aa overlap); AAG58557|UGPE SN-GLYCEROL 3-PHOSPHATE TRANSPORT SYSTEM (INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain O157:H7 and EDL933 (281 aa), FASTA scores: opt: 574, E(): 3.7e-29, (32.95% identity in 264 aa overlap); P10906|UGPE_ECOLI|B3451 SN-GLYCEROL-3-PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN from Escherichia coli strain K12 (281 aa), FASTA scores: opt: 569, E(): 7.6e-29,(32.6% identity in 264 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Q7TXR3 No NC_002945.3 Mycobrowser_v2 CDS 3085906 3088344 . - 0 Mb2847c conserved protein Mb2847c, -, len: 812 aa. Equivalent to Rv2823c,len: 809 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 812 aa overlap). Conserved hypothetical protein, similar in part to others e.g. Q9X2D1|TM1811Thermotoga maritima (717 aa), FASTA scores: opt: 401, E(): 3.6e-18, (27.15% identity in 773 aa overlap); O27154|MTH1082 CONSERVED HYPOTHETICAL PROTEIN from Methanothermobacter thermautotrophicus (822 aa),FASTA scores: opt: 306, E(): 6e-12, (25.55% identity in 872 aa overlap); Q59066|MJ1672 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (800 aa), FASTA scores: opt: 302,E(): 1.1e-11, (24.9% identity in 812 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp insertion (*-cggcgatgt) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7TXS4 No conserved hypotheticals Rv2823c NC_002945.3 Mycobrowser_v2 CDS 3088341 3089285 . - 0 Mb2848c HYPOTHETICAL PROTEIN Mb2848c, -, len: 314 aa. Equivalent to Rv2824c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 314 aa overlap). Hypothetical unknown protein. Q7TXS3 No conserved hypotheticals Rv2824c NC_002945.3 Mycobrowser_v2 CDS 3089463 3090110 . - 0 Mb2849c CONSERVED HYPOTHETICAL PROTEIN Mb2849c, -, len: 215 aa. Equivalent to Rv2825c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(97.7% identity in 215 aa overlap). Conserved hypothetical protein, similar to Q9RY53|DR0097 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FASTA scores: opt: 261, E(): 8e-11, (33.5% identity in 176 aa overlap); and shows some similarity with N-terminus of O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN from Methanothermobacter thermautotrophicus (340 aa), FASTA scores: opt: 133, E(): 0.091, (28.55% identity in 112 aa overlap). Equivalent to AAK47217 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 31 aa; and equivalent to upstream ORF P71624|Rv2828c|MTCY16B7.14 from Mycobacterium tuberculosis strain H37Rv (alias AAK47221 from strain CDC1551) (181 aa), FASTA scores: opt: 1169, E(): 8.5e-74, (98.35% identity in 181 aa overlap). Q7TXS2 No conserved hypotheticals Rv2825c NC_002945.3 Mycobrowser_v2 CDS 3090280 3091164 . - 0 Mb2850c HYPOTHETICAL PROTEIN Mb2850c, -, len: 294 aa. Equivalent to Rv2826c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Hypothetical unknown protein. Q7TXS1 No conserved hypotheticals Rv2826c NC_002945.3 Mycobrowser_v2 CDS 3091167 3092054 . - 0 Mb2851c HYPOTHETICAL PROTEIN Mb2851c, -, len: 295 aa. Equivalent to Rv2827c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Hypothetical unknown protein, equivalent to AAK47219 from Mycobacterium tuberculosis strain CDC1551 (315 aa) but shorter 20 aa. Q7TXS0 No conserved hypotheticals Rv2827c NC_002945.3 Mycobrowser_v2 CDS 3095745 3097055 . - 0 Mb2857c ugpB PROBABLE Sn-GLYCEROL-3-PHOSPHATE-BINDING LIPOPROTEIN UGPB Mb2857c, ugpB, len: 436 aa. Equivalent to Rv2833c,len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 436 aa overlap). Probable ugpB,Sn-glycerol-3-phosphate binding lipoprotein component of Sn-glycerol-3-phosphate transport system (see citation below), similar to various transporters substrate-binding periplasmic proteins e.g. Q9KDY2|BH1079 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (GLYCEROL-3-PHOSPHATE BINDING PROTEIN) from Bacillus halodurans (459 aa), FASTA scores: opt: 357, E(): 3.1e-14, (23.4% identity in 406 aa overlap); P72397|MALE PUTATIVE MALTOSE-BINDING PROTEIN from Streptomyces coelicolor (423 aa), FASTA scores: opt: 318, E(): 7e-12, (23.7% identity in 430 aa overlap); AAK78409|CAC0429 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER PERIPLASMIC COMPONENT from Clostridium acetobutylicum (447 aa), FASTA scores: opt: 305, E(): 4.5e-11, (27.15% identity in 438 aa overlap); P10904|UGPB_ECOLI|B3453 GLYCEROL-3-PHOSPHATE-BINDING PERIPLASMIC PROTEIN PRECURSOR from Escherichia coli strain K12 (438 aa); etc. Contains signal sequence and appropriately positioned prokaryotic lipoprotein attachment site (PS00013). Q7TXR4 No NC_002945.3 Mycobrowser_v2 CDS 3092359 3092904 . - 0 Mb2852c CONSERVED HYPOTHETICAL PROTEIN Mb2852c, -, len: 181 aa. Equivalent to Rv2828c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 181 aa overlap). Conserved hypothetical protein, similar to Q9RY53|DR0097 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FASTA scores: opt: 267, E(): 1.9e-11, (34.1% identity in 176 aa overlap); and shows some similarity with N-terminus of O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN from Methanothermobacter thermautotrophicus (340 aa), FASTA scores: opt: 133, E(): 0.07, (28.55% identity in 112 aa overlap). Also equivalent to downstream ORF P71627|Rv2825c|MTCY16B7.17 from Mycobacterium tuberculosis strain H37Rv (alias AAK47217 from strain CDC1551, 246 aa) (215 aa), FASTA scores: opt: 1173, E(): 8.3e-75, (98.9% identity in 181 aa overlap). Q7TXR9 No conserved hypotheticals Rv2828c NC_002945.3 Mycobrowser_v2 CDS 3092901 3093170 . - 0 Mb2852A Conserved hypothetical protein Mb2852A, len: 89 aa. Equivalent to Rv2828A len: 89 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein,present in many mycobacteria. Equivalent to BCG2848c and Mb2852A (100% identity to both in 89 aa overlap) X2BM00 No conserved hypotheticals Rv2828A NC_002945.3 Mycobrowser_v2 CDS 3093191 3093583 . - 0 Mb2853c vapc22 possible toxin vapc22 Mb2853c, -, len: 130 aa. Equivalent to Rv2829c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Conserved hypothetical protein similar to AAK65872|SMA2253 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (125 aa), FASTA scores: opt: 171,E(): 7.7e-05, (34.9% identity in 129 aa overlap); and shows some similarity with other proteins e.g. Q9AH69 HYPOTHETICAL 14.7 KDA PROTEIN from Neisseria meningitidis (128 aa), FASTA scores: opt: 148, E(): 0.0031, (28.1% identity in 121 aa overlap). Q7TXR8 No virulence, detoxification, adaptation Rv2829c NC_002945.3 Mycobrowser_v2 CDS 3117096 3118577 . - 0 Mb2877c mqo PROBABLE MALATE:QUINONE OXIDOREDUCTASE MQO (MALATE DEHYDROGENASE [ACCEPTOR]) Mb2877c, mqo, len: 493 aa. Equivalent to Rv2852c,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 493 aa overlap). Probable mqo,malate:quinone oxidoreductase (EC 1.1.99.16), highly similar to others e.g. O69282|MQO_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (499 aa), FASTA scores: opt: 1701, E(): 1.2e-101, (50.7% identity in 495 aa overlap); Q9Z9Q7|BH3960 from Bacillus halodurans (500 aa), FASTA scores: opt: 1632, E(): 3.3e-97, (48.55% identity in 486 aa overlap); Q9HYF4|MQOA|PA3452 from Pseudomonas aeruginosa (523 aa),FASTA scores: opt: 1604, E(): 2.1e-95, (49.1% identity in 487 aa overlap) (N-terminus longer); P33940|MQO_ECOLI|B2210 from Escherichia coli strain K12 (548 aa), FASTA scores: opt: 1525, E(): 2.7e-90, (48.15% identity in 492 aa overlap); etc. BELONGS TO THE MQO FAMILY. COFACTORS: FAD. X2BM23,P65420 No NC_002945.3 Mycobrowser_v2 CDS 3093842 3094591 . + 0 Mb2855 echA16 PROBABLE ENOYL-COA HYDRATASE ECHA16 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb2855, echA16, len: 249 aa. Equivalent to Rv2831,len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 249 aa overlap). Probable echA16,enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. O23468|AT4G16210 from Arabidopsis thaliana (Mouse-ear cress) (244 aa), FASTA scores: opt: 491, E(): 7.3e-25,(42.1% identity in 190 aa overlap); Q98LI4|MLL1009 from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 491, E(): 7.6e-25, (40.75% identity in 248 aa overlap); O07137|ECH8_MYCLE|ML2402|MLCB1306.05c from Mycobacterium leprae (257 aa), FASTA scores: opt: 478,E(): 5.3e-24, (38.05% identity in 226 aa overlap); P76082|PAAF_ECOLI|B1393 from scherichia coli strain K12 (255 aa), FASTA scores: opt: 439, E(): 1.9e-21, (37.55% identity in 221 aa overlap); etc. Also similar to O53418|ECH8_MYCTU|ECHA8|Rv1070c|MT1100|MTV017.23c from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 471, E(): 1.5e-23, (38.05% identity in 226 aa overlap). Q7TXR6 No NC_002945.3 Mycobrowser_v2 CDS 3094670 3095752 . - 0 Mb2856c ugpC PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER UGPC Mb2856c, ugpC, len: 360 aa. Equivalent to Rv2832c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 360 aa overlap). Probable ugpC,Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter (see first citation below), similar to others: CAC48805 PROBABLE GLYCEROL-3-PHOSPHATE ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (349 aa), FASTA scores: opt: 1018,E(): 4.1e-53, (48.6% identity in 356 aa overlap); Q98G42|MLL3499|UGPC SN-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN from Rhizobium loti (Mesorhizobium loti) (366 aa), FASTA scores: opt: 1016, E(): 5.6e-53,(48.5% identity in 367 aa overlap). But also highly similar to many msiK proteins, ABC transporter ATP-binding proteins possibly involved in transport of cellolbiose and maltose (see second citation below) e.g. P96483|MSIK MSIK PROTEIN from Streptomyces reticuli (see citation below) (377 aa), FASTA scores: opt: 1277, E(): 1.9e-68, (58.05% identity in 379 aa overlap); Q9L0Q1|MSIK ABC TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (378 aa),FASTA scores: opt: 1276, E(): 2.1e-68, (57.65% identity in 380 aa overlap); Q54333|MSIK from Streptomyces lividans (314 aa), FASTA scores: opt: 1217, E(): 5.9e-65, (63.7% identity in 292 aa overlap); and other ABC-TYPE SUGAR TRANSPORT PROTEINS. Also highly similar to O53482|Rv2038c|MTV018.25c ABC-TYPE SUGAR TRANSPORT PROTEIN from Mycobacterium tuberculosis (357 aa), FASTA scores: opt: 1248, E(): 9.4e-67, (56.8% identity in 354 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TXR5 No NC_002945.3 Mycobrowser_v2 CDS 3104529 3104828 . - 0 Mb2865c CONSERVED HYPOTHETICAL PROTEIN Mb2865c, -, len: 99 aa. Equivalent to Rv2840c, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein, equivalent to Q9Z5J0|ML1557|MLCB596.13 HYPOTHETICAL 11.6 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 501, E(): 2.3e-29, (501% identity in 96 aa overlap). Also highly similar to other hypothetical proteins e.g. Q9KYR0|SC5H4.29 from Streptomyces coelicolor (101 aa), FASTA scores: opt: 256,E(): 1.4e-11, (50.6% identity in 81 aa overlap); Q9APM9 from Myxococcus xanthus (111 aa), FASTA scores: opt: 174,E(): 1.3e-05, (42.25% identity in 97 aa overlap); and similar to to others e.g. N-terminus of CAC41675|SMC02913 from Rhizobium meliloti (Sinorhizobium meliloti) (230 aa),FASTA scores: opt: 172, E(): 3e-05, (42.4% identity in 66 aa overlap). Q7TXQ8 No conserved hypotheticals Rv2840c NC_002945.3 Mycobrowser_v2 CDS 3097882 3098424 . - 0 Mb2859c ugpAb PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPAB [SECOND PART] Mb2859c, ugpAb, len: 180 aa. Equivalent to 3' end of Rv2835c, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 180 aa overlap). Probable ugpA, Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below),similar to various permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR TRANSPORTER INNER MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35,(38.85% identity in 291 aa overlap); Q9KDY4|BH1077 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (315 aa), FASTA scores: opt: 548, E(): 6.2e-29, (31.5% identity in 295 aa overlap); AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER,PERMEASE COMPONENT from Clostridium acetobutylicum (304 aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity in 292 aa overlap); etc. Contains PS00062 Aldo/keto reductase family signature 2, and PS00402 Binding-protein-dependent transport systems inner membrane comp signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb. Q7TXR2 No NC_002945.3 Mycobrowser_v2 CDS 3098421 3098792 . - 0 Mb2860c ugpAa PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPAA [FIRST PART] Mb2860c, ugpAa, len: 123 aa. Similar to 5' end of Rv2835c, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 85 aa overlap). Probable ugpA, Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR TRANSPORTER INNER MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35,(38.85% identity in 291 aa overlap); Q9KDY4|BH1077 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (315 aa), FASTA scores: opt: 548, E(): 6.2e-29, (31.5% identity in 295 aa overlap); AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER,PERMEASE COMPONENT from Clostridium acetobutylicum (304 aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity in 292 aa overlap); etc. Contains PS00062 Aldo/keto reductase family signature 2, and PS00402 Binding-protein-dependent transport systems inner membrane comp signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb. Q7TXR1 No NC_002945.3 Mycobrowser_v2 CDS 3098879 3100198 . - 0 Mb2861c dinF POSSIBLE DNA-DAMAGE-INDUCIBLE PROTEIN F DINF Mb2861c, dinF, len: 439 aa. Equivalent to Rv2836c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Possible dinF,DNA-damage-inducible protein F, integral membrane protein,similar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 (459 aa), FASTA scores: opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli strain K12 (459 aa), FASTA scores: opt: 491, E(): 1e-20,(29.35% identity in 443 aa overlap); Q98B90|MLR5680 from Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA scores: opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa overlap); etc. But also similar or highly similar to other hypothetical proteins e.g. Q9X8U6|SCH24.32c HYPOTHETICAL 46.3 KDA PROTEIN from Streptomyces coelicolor (448 aa),FASTA scores: opt: 981, E(): 1.1e-48, (42.35% identity in 437 aa overlap). Contains PS00213 Lipocalin signature. Q7TXR0 No NC_002945.3 Mycobrowser_v2 CDS 3100205 3101215 . - 0 Mb2862c conserved protein Mb2862c, -, len: 336 aa. Equivalent to Rv2837c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Conserved hypothetical protein, showing some similarity with other proteins e.g. O67552|AQ_1630 HYPOTHETICAL 36.2 KDA PROTEIN from Aquifex aeolicus (325 aa), FASTA scores: opt: 498,E(): 3.6e-25, (32.8% identity in 314 aa overlap); Q9X1T1|TM1595 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (333 aa), FASTA scores: opt: 482, E(): 4.1e-24, (34.85% identity in 304 aa overlap); Q9RW43|DR0826 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (338 aa), FASTA scores: opt: 444,E(): 1.3e-21, (33.85% identity in 331 aa overlap); etc. Equivalent to AAK47229 from Mycobacterium tuberculosis strain CDC1551 (316 aa) but longer 20 aa. Q7TXQ9 No conserved hypotheticals Rv2837c NC_002945.3 Mycobrowser_v2 CDS 3101190 3101741 . - 0 Mb2863c rbfA PROBABLE RIBOSOME-BINDING FACTOR A RBFA (P15B PROTEIN) Mb2863c, rbfA, len: 183 aa. Equivalent to Rv2838c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Probable rbfA,ribosome-binding factor A, equivalent to Q9Z5I8|RBFA_MYCLE|ML1555|MLCB596.15 PROBABLE RIBOSOME-BINDING FACTOR A from Mycobacterium leprae (164 aa), FASTA scores: opt: 739, E(): 1.8e-40, (75.6% identity in 160 aa overlap). Also highly similar or similar to others e.g. Q9Z527|RBFA_STRCO|SC9F2.08c from Streptomyces coelicolor (160 aa), FASTA scores: opt: 425, E(): 2.8e-20,(50.35% identity in 141 aa overlap); P32731|RBFA_BACSU from Bacillus subtilis (117 aa), FASTA scores: opt: 199,E(): 7.8e-06, (32.4% identity in 108 aa overlap); P09170|RBFA_ECOLI|P15B|B3167 from Escherichia coli strain K12 (132 aa), FASTA scores: opt: 166, E(): 0.0011, (29.65% identity in 118 aa overlap); etc. BELONGS TO THE RBFA FAMILY. Note that appears to be longer in C-terminus than other RbfA proteins. X2BLP7,P65965 No NC_002945.3 Mycobrowser_v2 CDS 3127236 3128162 . - 0 Mb2884c POSSIBLE AMIDOTRANSFERASE Mb2884c, -, len: 308 aa. Equivalent to Rv2859c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Possible amidotransferase (EC 6.3.5.- or 2.-.-.-), equivalent (but longer 58 aa) to Q9CBU9|ML1573 POSSIBLE AMIDOTRANSFERASE from Mycobacterium leprae (249 aa), FASTA scores: opt: 1226, E(): 3e-64, (71.55% identity in 239 aa overlap). Also similar to other amidotransferases and hypothetical proteins, but shorter in N-terminus e.g. O88072|SCI35.37 HYPOTHETICAL 25.3 KDA PROTEIN from Streptomyces coelicolor (242 aa), FASTA scores: opt: 683, E(): 1.2e-32, (47.65% identity in 235 aa overlap); AAK79730|Q97I88|CAC1764 PREDICTED GLUTAMINE AMIDOTRANSFERASE from Clostridium acetobutylicum (241 aa), FASTA scores: opt: 458, E(): 1.6e-19, (32.95% identity in 246 aa overlap); AAK75201|Q97QV9|SP1089 GLUTAMINE AMIDOTRANSFERASE CLASS I from Streptococcus pneumoniae (229 aa), FASTA scores: opt: 431, E(): 5.6e-18, (34.75% identity in 236 aa overlap); etc. Contains three 17 aa repeats at the N-terminus very similar to those in other Mycobacterium tuberculosis proteins e.g. Q10699|YY30_MYCTU|Rv2090|MT2151|MTCY49.30 PUTATIVE 5'-3' EXONUCLEASE RV2090 (EC 3.1.11.-). Q7TXP4 No intermediary metabolism and respiration Rv2859c NC_002945.3 Mycobrowser_v2 CDS 3104955 3105998 . - 0 Mb2866c nusA PROBABLE N UTILIZATION SUBSTANCE PROTEIN A NUSA Mb2866c, nusA, len: 347 aa. Equivalent to Rv2841c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Probable nusA,N-utilization substance protein A, equivalent to Q9Z5J1|NUSA|ML1558 PROBABLE TRANSCRIPTION TERMINATION/ANTITERMINATION FACTOR from Mycobacterium leprae (347 aa), FASTA scores: opt: 2054, E(): 5.4e-120,(91.95% identity in 347 aa overlap). Also highly similar to others e.g. Q9KYR1|SC5H4.28 PUTATIVE TRANSCRIPTIONAL TERMINATION/ANTITERMINATION FACTOR from Streptomyces coelicolor (340 aa), FASTA scores: opt: 1346, E(): 4.3e-76, (63.35% identity in 341 aa overlap); P32727|NUSA_BACSU N UTILIZATION SUBSTANCE PROTEIN A (371 aa), FASTA scores: opt: 847, E(): 4.1e-45, (43.95% identity in 346 aa overlap); Q9KA74|NUSA|BH2416 TRANSCRIPTIONAL TERMINATOR from Bacillus halodurans (382 aa), FASTA scores: opt: 846, E(): 4.8e-45, (43.15% identity in 373 aa overlap); etc. BELONGS TO THE NUSA FAMILY. X2BLQ9,P0A5M3 No NC_002945.3 Mycobrowser_v2 CDS 3105995 3106546 . - 0 Mb2867c conserved protein Mb2867c, -, len: 183 aa. Equivalent to Rv2842c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, similar to Q9Z5J2|MLCB596.11 HYPOTHETICAL 13.7 KDA PROTEIN from Mycobacterium leprae (122 aa), FASTA scores: opt: 192, E(): 2.1e-12, (50.0% identity in 128 aa overlap) (N-terminus shorter). Also similar in part to several hypothetical proteins e.g. Q9KYR2|SC5H4.27 HYPOTHETICAL 19.8 KDA PROTEIN from Streptomyces coelicolor (177 aa), FASTA scores: opt: 288,E(): 2.1e-12, (37.15% identity in 148 aa overlap); O66619|Y260_AQUAE|AQ_260 HYPOTHETICAL PROTEIN from Aquifex aeolicus (158 aa), FASTA scores: opt: 230, E(): 1.7e-08,(31.35% identity in 153 aa overlap); Q9KU82|VC0641 HYPOTHETICAL PROTEIN from Vibrio cholerae (151 aa), FASTA scores: opt: 198, E(): 2.5e-06, (30.9% identity in 152 aa overlap); etc. X2BM18,P67215 No conserved hypotheticals Rv2842c NC_002945.3 Mycobrowser_v2 CDS 3106741 3107286 . + 0 Mb2868 PROBABLE CONSERVED TRANSMEMBRANE ALANINE RICH PROTEIN Mb2868, -, len: 181 aa. Equivalent to Rv2843, len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Probable conserved transmembrane ala-rich protein, equivalent to Q9Z5J3|ML1560|MLCB596.10c HYPOTHETICAL 17.5 KDA PROTEIN from Mycobacterium leprae (178 aa), FASTA scores: opt: 707, E(): 1.4e-32, (70.25% identity in 168 aa overlap). Q7TXQ7 No cell wall and cell processes Rv2843 NC_002945.3 Mycobrowser_v2 CDS 3107283 3107771 . + 0 Mb2869 conserved alanine rich protein Mb2869, -, len: 162 aa. Equivalent to Rv2844, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q9Z5J4|ML1561|MLCB596.09c HYPOTHETICAL 17.5 KDA PROTEIN from Mycobacterium leprae (165 aa), FASTA scores: opt: 771, E(): 4.9e-46, (71.5% identity in 165 aa overlap). Also similar to Q9KYR4|SC5H4.25c HYPOTHETICAL 16.8 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 242, E(): 1.6e-09, (38.9% identity in 144 aa overlap). Q7TXQ6 No conserved hypotheticals Rv2844 NC_002945.3 Mycobrowser_v2 CDS 3128143 3129516 . - 0 Mb2885c glnA4 PROBABLE GLUTAMINE SYNTHETASE GLNA4 (GLUTAMINE SYNTHASE) (GS-II) Mb2885c, glnA4, len: 457 aa. Equivalent to Rv2860c,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 457 aa overlap). Probable glnA4,glutamine synthetase class II (EC 6.3.1.2), similar to many glutamine synthases e.g. O88070|SCI35.35c from Streptomyces coelicolor (462 aa), FASTA scores: opt: 1947,E(): 8.2e-120, (64.15% identity in 452 aa overlap); Q98H15|MLL3074 from Rhizobium loti (Mesorhizobium loti) (465 aa), FASTA scores: opt: 1321, E(): 7.8e-79, (46.7% identity in 452 aa overlap); Q98EM0|MLL4187 from Rhizobium loti (Mesorhizobium loti) (456 aa), FASTA scores: opt: 698, E(): 4.6e-38, (33.5% identity in 454 aa overlap); Q9CDL9|GLNA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (446 aa), FASTA scores: opt: 633,E(): 8.2e-34, (32.45% identity in 456 aa overlap); etc. Also similar to three other potential glutamine synthases in Mycobacterium tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427 .03c PROBABLE GLUTAMINE SYNTHETASE (446 aa), FASTA score: (31.1% identity in 453 aa overlap); Rv1878|glnA3 and Rv2220|glnA1. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY. Q7TXP3 No NC_002945.3 Mycobrowser_v2 CDS 3107772 3109520 . - 0 Mb2870c proS probable prolyl-trna synthetase pros (proline--trna ligase) (prors) (global rna synthesis factor) (proline translase) Mb2870c, proS, len: 582 aa. Equivalent to Rv2845c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 582 aa overlap). Probable proS,prolyl-tRNA synthetase (EC 6.1.1.15), highly similar to others e.g. Q9KYR6|SYP_STRCO|PROS|SC5H4.23 from Streptomyces coelicolor (567 aa), FASTA scores: opt: 1161,E(): 9e-64, (57.15% identity in 574 aa overlap); P56124|SYP_HELPY|PROS|HP0238 from Helicobacter pylori (Campylobacter pylori) (577 aa), FASTA scores: opt: 1082,E(): 6.6e-59, (37.8% identity in 553 aa overlap); P16659|SYP_ECOLI|PROS|DRPA|B0194 from Escherichia coli strain K12 (572 aa), FASTA scores: opt: 926, E(): 2.6e-49,(39.85% identity in 587 aa overlap); etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. X2BMK4,Q7TXQ5 No NC_002945.3 Mycobrowser_v2 CDS 3109609 3111201 . - 0 Mb2871c efpA POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA Mb2871c, efpA, len: 530 aa. Equivalent to Rv2846c,len: 530 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 530 aa overlap). Possible efpA,integral membrane efflux protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug (see citations below), equivalent to Q9Z5J5|ML1562|MLCB596.08 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Mycobacterium leprae (534 aa), FASTA scores: opt: 2881, E(): 4.1e-160, (86.55% identity in 535 aa overlap). Also highly similar to several membrane proteins e.g. O69986|SC4H2.31c TRANSMEMBRANE EFFLUX PROTEIN (515 aa), FASTA scores: opt: 1063, E(): 2.2e-54, (39.65% identity in 406 aa overlap); Q9FBQ5|SCD86A.02c PUTATIVE TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (503 aa), FASTA scores: opt: 918, E(): 5.8e-46,(33.7% identity in 469 aa overlap); Q9KYU0|SCE22.23c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (514 aa), FASTA scores: opt: 888, E(): 3.3e-44,(32.85% identity in 469 aa overlap); etc. Q7TXQ4 No NC_002945.3 Mycobrowser_v2 CDS 3112664 3114037 . - 0 Mb2873c cobB PROBABLE COBYRINIC ACID A,C-DIAMIDE SYNTHASE COBB Mb2873c, cobB, len: 457 aa. Equivalent to Rv2848c,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 457 aa overlap). Probable cobB,cobyrinic acid A,C-diamide synthase, highly similar to others e.g. O27509|COBB_METTH|MTH1460 from Methanobacterium thermoautotrophicum (447 aa), FASTA scores: opt: 980, E(): 1.3e-49, (39.65% identity in 454 aa overlap); Q9KBM8|BH1898 from Bacillus halodurans (465 aa),FASTA scores: opt: 928, E(): 1.4e-46, (37.0% identity in 457 aa overlap); O68108|COBB_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (435 aa), FASTA scores: opt: 921, E(): 3.3e-46, (39.35% identity in 437 aa overlap); etc. BELONGS TO THE COBB/COBQ FAMILY, COBB SUBFAMILY. X2BLS0,P63836 No NC_002945.3 Mycobrowser_v2 CDS 3114037 3114660 . - 0 Mb2874c cobO PROBABLE COB(I)ALAMIN ADENOSYLTRANSFERASE COBO (CORRINOID ADENOSYLTRANSFERASE) (CORRINOID ADOTRANSFERASE ACTIVITY) Mb2874c, cobO, len: 207 aa. Equivalent to Rv2849c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 207 aa overlap). Probable cobO,cob(I)alamin adenosyltransferase (EC 2.5.1.17), highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75% identity in 207 aa overlap); and similar to others e.g. O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212 aa), FASTA scores: opt: 329, E(): 2.8e-15,(44.3% identity in 185 aa overlap); P29930|COBO_PSEDE from Pseudomonas denitrificans (213 aa), FASTA scores: opt: 280, E(): 6.5e-12, (38.9% identity in 185 aa overlap); P31570|BTUR_SALTY|COBA from Salmonella typhimurium (196 aa), FASTA scores: opt: 278, E(): 8.4e-12, (39.8% identity in 196 aa overlap); etc. COFACTOR: MANGANESE. Note that previously known as cobA. Q7TXQ2 No NC_002945.3 Mycobrowser_v2 CDS 3114681 3116570 . - 0 Mb2875c POSSIBLE MAGNESIUM CHELATASE Mb2875c, -, len: 629 aa. Equivalent to Rv2850c,len: 629 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 629 aa overlap). Possible magnesium-chelatase (EC 4.99.1.-), highly similar (but with gaps) to magnesium-chelatases from notably photosynthetic organisms involved in chlorophyll biosynthesis e.g. Q9RJ18|SCI8.35c PUTATIVE CHELATASE from Streptomyces coelicolor (672 aa), FASTA scores: opt: 1941,E(): 2.1e-85, (54.65% identity in 675 aa overlap); Q9HZQ5|PA2942 PROBABLE MAGNESIUM CHELATASE from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 991,E(): 2.7e-40, (49.45% identity in 368 aa overlap); O33549|BCHI MG PROTOPORPHYRIN IX CHELATASE SUBUNIT from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa), FASTA scores: opt: 833, E(): 9.4e-33, (50.65% identity in 318 aa overlap); O30819|BCHI_RHOSH MAGNESIUM-CHELATASE 38 KDA SUBUNIT from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa), FASTA scores: opt: 828, E(): 1.6e-32, (50.3% identity in 318 aa overlap); etc. Equivalent to AAK47242 from Mycobacterium tuberculosis strain CDC1551 (610 aa) but longer 19 aa. COULB BELONG TO THE MG-CHELATASE SUBUNITS D/I FAMILY. Q7TXQ1 No intermediary metabolism and respiration Rv2850c NC_002945.3 Mycobrowser_v2 CDS 3116567 3117037 . - 0 Mb2876c gcn5-related n-acetyltransferase Mb2876c, -, len: 156 aa. Equivalent to Rv2851c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, similar to various bacterial proteins e.g. Q9KP14|VC2565 ELAA PROTEIN from Vibrio cholerae (149 aa), FASTA scores: opt: 360, E(): 1e-18,(46.05% identity in 139 aa overlap); Q9I717|PA0115 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (150 aa),FASTA scores: opt: 341, E(): 2.4e-17, (43.65% identity in 142 aa overlap); Q9K8M4|BH2982 HYPOTHETICAL PROTEIN from Bacillus halodurans (155 aa), FASTA scores: opt: 320, E(): 8e-16, (40.85% identity in 142 aa overlap); P52077|ELAA_ECOLI|B2267 PROTEIN ELAA from Escherichia coli strain K12 (153 aa), FASTA scores: opt: 269, E(): 3.8e-12,(35.7% identity in 140 aa overlap); etc. X2BLR6,P67105 No intermediary metabolism and respiration Rv2851c NC_002945.3 Mycobrowser_v2 CDS 3134974 3135828 . - 0 Mb2892c gcn5-related n-acetyltransferase Mb2892c, -, len: 284 aa. Equivalent to Rv2867c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Conserved hypothetical protein, similar to Q9KYR8|SC5H4.21 HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces coelicolor (287 aa), FASTA scores: opt: 798, E(): 2.4e-45, (47.95% identity in 269 aa overlap). Q7TXN7 No intermediary metabolism and respiration Rv2867c NC_002945.3 Mycobrowser_v2 CDS 3125099 3125875 . - 0 Mb2882c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb2882c, -, len: 258 aa. Equivalent to Rv2857c,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. O88068|SCI35.33c PROBABLE DEHYDROGENASE (SDR FAMILY) from Streptomyces coelicolor (260 aa), FASTA scores: opt: 1208, E(): 2e-68, (72.35% identity in 253 aa overlap); Q9I376|PA1649 from Pseudomonas aeruginosa PROBABLE SHORT-CHAIN DEHYDROGENASE (253 aa), FASTA scores: opt: 569, E(): 2.1e-28, (39.2% identity in 255 aa overlap); Q9EX74|MLHA SDR-LIKE ENZYME from Rhodococcus erythropolis (246 aa), FASTA scores: opt: 567, E(): 2.8e-28, (41.15% identity in 248 aa overlap); etc. Also similar to many Mycobacterium tuberculosis dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c PUTATIVE OXIDOREDUCTASE (260 aa), FASTA score: (38.3% identity in 248 aa overlap). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TXP6 No intermediary metabolism and respiration Rv2857c NC_002945.3 Mycobrowser_v2 CDS 3143546 3144127 . + 0 Mb2900 mpt70 major secreted immunogenic protein mpt70 Mb2900, mpb70, len: 193 aa. Equivalent to Rv2875,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 193 aa overlap). mpt70 (alternate gene name: mpb70), major secreted immunogenic protein MPT70 precursor (see citations below). Also similar to downstream ORF Q10790|MP83_MYCTU|MPT83|MPB83|Rv2873|MT2940|MTCY274.04 CELL SURFACE LIPOPROTEIN MPT83 PRECURSOR (LIPOPROTEIN P23) (220 aa), FASTA scores: opt: 806, E(): 1.2e-40, (70.25% identity in 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FAMILY. GENERALLY FOUND AS A MONOMER; HOMODIMER IN CULTURE FLUIDS. X2BLT4,P0A669 No NC_002945.3 Mycobrowser_v2 CDS 3139654 3139911 . + 0 Mb2896 vapb43 possible antitoxin vapb43 Mb2896, -, len: 85 aa. Equivalent to Rv2871, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein (see citation below), similar to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50456|Rv1241|MTV006.13 (86 aa), FASTA scores: opt: 172, E(): 2.9e-05, (37.2% identity in 86 aa overlap); O53811|Rv0748|MTV041.22 (85 aa), FASTA scores: opt: 170, E(): 4e-05, (35.3% identity in 85 aa overlap); etc. X2BM36,P0A5H0 No virulence, detoxification, adaptation Rv2871 NC_002945.3 Mycobrowser_v2 CDS 3118784 3120631 . + 0 Mb2878 PE_PGRS48 pe-pgrs family protein pe_pgrs48 Mb2878, PE_PGRS48, len: 615 aa. Equivalent to Rv2853, len: 615 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 615 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. O53884|Rv0872c|MTV043.65c from Mycobacterium tuberculosis (606 aa), FASTA scores: opt: 1405, E(): 1.4e-97, (64.6% identity in 619 aa overlap). Equivalent to AAK47245 from Mycobacterium tuberculosis strain CDC1551 (663 aa) but shorter 48 aa. Q7TXQ0 No NC_002945.3 Mycobrowser_v2 CDS 3120668 3121708 . + 0 Mb2879 unknown protein Mb2879, -, len: 346 aa. Equivalent to Rv2854, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Hypothetical unknown protein, showing similarity with Q9CD03|ML2603 HYPOTHETICAL PROTEIN from Mycobacterium leprae (279 aa),FASTA scores: opt: 154, E(): 0.0083, (33.35% identity in 87 aa overlap). Q7TXP9 No conserved hypotheticals Rv2854 NC_002945.3 Mycobrowser_v2 CDS 3121721 3123100 . + 0 Mb2880 mtr nadph-dependent mycothiol reductase mtr Mb2880, mtr, len: 459 aa. Equivalent to Rv2855,len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable mtr,mycothiol reductase (EC 1.-.-.-), proven enzymatically but previously described as glutathione reductase homolog (gene name: gorA) (see citation below). Similar to others e.g. Q9L7K8|MERA MERCURIC REDUCTASE from Streptomyces sp. CHR28 (474 aa), FASTA scores: opt: 719, E(): 9e-38, (35.2% identity in 460 aa overlap); P30341|MERA_STRLI MERCURIC REDUCTASE (EC 1.16.1.1) from Streptomyces lividans (474 aa), FASTA scores: opt: 712, E(): 2.5e-37, (34.95% identity in 455 aa overlap); Q98ED5|MLL4296 FERRIC LEGHEMOGLOBIN REDUCTASE-2 PRECURSOR, DIHYDROLIPOAMIDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (468 aa), FASTA scores: opt: 670, E(): 1.1e-34, (30.8% identity in 471 aa overlap); etc. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD. Q7TXP8 No intermediary metabolism and respiration Rv2855 NC_002945.3 Mycobrowser_v2 CDS 3123200 3124318 . + 0 Mb2881 nicT POSSIBLE NICKEL-TRANSPORT INTEGRAL MEMBRANE PROTEIN NICT Mb2881, nicT, len: 372 aa. Equivalent to Rv2856,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 372 aa overlap). Possible nicT,nickel-transport integral membrane protein, similar to transport proteins and hydrogenase cluster proteins e.g. BAB58860|SAV2698 HYPOTHETICAL 37.9 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (338 aa), FASTA scores: opt: 1082, E(): 7.1e-60, (48.05% identity in 335 aa overlap); Q97ZB2|HOXN HIGH-AFFINITY NICKEL-TRANSPORT PROTEIN from Sulfolobus solfataricus (373 aa), FASTA scores: opt: 922, E(): 6.6e-50, (42.2% identity in 372 aa overlap); P23516|HOXN_ALCEU HIGH-AFFINITY NICKEL TRANSPORT PROTEIN (INTEGRAL MEMBRANE PROTEIN) from Alcaligenes eutrophus (Ralstonia eutropha) (351 aa), FASTA scores: opt: 904, E(): 8.3e-49, (41.9% identity in 339 aa overlap); Q45247|HUPN_BRAJA HYDROGENASE NICKEL INCORPORATION PROTEIN from Bradyrhizobium japonicum (381 aa), FASTA scores: opt: 853, E(): 1.3e-45, (41.65% identity in 329 aa overlap); etc. SEEMS TO BELONG TO THE HOXN/HUPN/NIXA FAMILY OF NICKEL TRANSPORTERS (NiCoT FAMILY). Q7TXP7 No cell wall and cell processes Rv2856 NC_002945.3 Mycobrowser_v2 CDS 3125872 3127239 . - 0 Mb2883c aldC PROBABLE ALDEHYDE DEHYDROGENASE ALDC Mb2883c, aldC, len: 455 aa. Equivalent to Rv2858c,len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 455 aa overlap). Probable aldC,aldehyde dehydrogenase (EC 1.2.1.3), similar to many e.g. O88069|SCI35.34c PUTATIVE ALDEHYDE DEHYDROGENASE from Streptomyces coelicolor (483 aa), FASTA scores: opt: 1872,E(): 6.4e-109, (64.5% identity in 448 aa overlap); Q9FAB1|ALDH|BT-ALDH ALDEHYDE DEHYDROGENASE from Bacillus thermoleovorans (497 aa), FASTA scores: opt: 1157, E(): 2.1e-64, (44.3% identity in 458 aa overlap); O33455|CYMC P-CUMIC ALDEHYDE DEHYDROGENASE from Pseudomonas putida (494 aa), FASTA scores: opt: 1149, E(): 6.5e-64, (43.15% identity in 452 aa overlap); P40047|DHA5_YEAST|ALD5|ALDH5|ALD3|YER073W ALDEHYDE DEHYDROGENASE from Saccharomyces cerevisiae (Baker's yeast) (519 aa), FASTA scores: opt: 1091, E(): 2.7e-60,(38.55% identity in 459 aa overlap); P80668|FEAB_ECOLI|PADA|MAOB|B1385 PHENYLACETALDEHYDE DEHYDROGENASE (EC 1.2.1.39) from Escherichia coli strain K12 (499 aa), FASTA scores: opt: 1074, E(): 3e-59, (42.2% identity in 462 aa overlap); etc. Also similar to many M. tuberculosis dehydrogenases e.g. P71823|Rv0768|MTCY369.13 (489 aa), FASTA score: (38.1% identity in 467 aa overlap). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Q7TXP5 No NC_002945.3 Mycobrowser_v2 CDS 3135884 3137047 . - 0 Mb2893c gcpE PROBABLE GCPE PROTEIN Mb2893c, gcpE, len: 387 aa. Equivalent to Rv2868c,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Probable gcpE protein (protein e), equivalent to Q9CBU5|GCPE|ML1581 HYPOTHETICAL PROTEIN GCPE from Mycobacterium leprae (392 aa), FASTA scores: opt: 2247, E(): 6.8e-134, (87.65% identity in 388 aa overlap). Highly similar to essential gene of unknown function from Escherichia coli and other prokaryotes e.g. Q9X7W2|GCPE_STRCO|SC6A5.16 GCPE PROTEIN HOMOLOG from Streptomyces coelicolor (384 aa), FASTA scores: opt: 1965,E(): 3.8e-116, (78.2% identity in 385 aa overlap); P54482|GCPE_BACSU GCPE PROTEIN HOMOLOG from Bacillus subtilis (377 aa), FASTA scores: opt: 1157, E(): 2.6e-65,(49.55% identity in 351 aa overlap); P27433|GCPE_ECOLI|B2515|Z3778|ECS3377 GCPE PROTEIN (PROTEIN E) from Escherichia coli strains K12 and O157:H7 (372 aa), FASTA scores: opt: 984, E(): 2e-54, (44.15% identity in 360 aa overlap); etc. BELONGS TO THE GCPE FAMILY. X2BM90,Q7TXN6 No NC_002945.3 Mycobrowser_v2 CDS 3131970 3133781 . - 0 Mb2889c POSSIBLE PENICILLIN-BINDING LIPOPROTEIN Mb2889c, -, len: 603 aa. Equivalent to Rv2864c,len: 603 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 603 aa overlap). Possible penicillin-binding lipoprotein, probably located in periplasm, equivalent to Q9CBU6|ML1577 PROBABLE PENICILLIN BINDING PROTEIN from Mycobacterium leprae (608 aa), FASTA scores: opt: 3352, E(): 2.1e-193, (81.5% identity in 606 aa overlap). Also shows some similarity to others e.g. P72405|PCBR from Streptomyces clavuligerus (551 aa), FASTA scores: opt: 543, E(): 6.1e-25, (28.4% identity in 567 aa overlap); Q9F2L0|SCH63.18c from Streptomyces coelicolor (546 aa), FASTA scores: opt: 519, E(): 1.7e-23, (29.3% identity in 577 aa overlap); Q9RKD1|SCE87.07 from Streptomyces coelicolor (541 aa), FASTA scores: opt: 472,E(): 1.1e-20, (34.3% identity in 318 aa overlap); etc. Equivalent to AAK47258 from Mycobacterium tuberculosis strain CDC1551 (618 aa) but shorter 15 aa. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS00017 ATP/GTP-binding site motif A (P-loop). Q7TXP0 No cell wall and cell processes Rv2864c NC_002945.3 Mycobrowser_v2 CDS 3137064 3138278 . - 0 Mb2894c rip membrane bound metalloprotease Mb2894c, -, len: 404 aa. Equivalent to Rv2869c,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 404 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CBU4|ML1582 PROBABLE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (404 aa), FASTA scores: opt: 2250, E(): 1.1e-128,(82.2% identity in 404 aa overlap). Also weakly similar to other membrane proteins or hypothetical proteins e.g. Q9A710|CC1916 PUTATIVE MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE from Caulobacter crescentus (398 aa),FASTA scores: opt: 368, E(): 7.8e-15, (28.1% identity in 427 aa overlap). Q7TXN5 No cell wall and cell processes Rv2869c NC_002945.3 Mycobrowser_v2 CDS 3129676 3130533 . - 0 Mb2886c mapB methionine aminopeptidase mapb (map) (peptidase m) Mb2886c, mapB, len: 285 aa. Equivalent to Rv2861c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 285 aa overlap). Probable mapB (alternate gene name: map), methionine aminopeptidase (EC 3.4.11.18), equivalent to Q9CBU7|MAPB|ML1576 METHIONINE AMINOPEPTIDASE from Mycobacterium leprae (285 aa), FASTA scores: opt: 1729, E(): 1e-99, (89.75% identity in 283 aa overlap). Also highly similar to many e.g. Q9RKR2|MAP3 from Streptomyces coelicolor (285 aa), FASTA scores: opt: 1385, E(): 2e-78, (70.65% identity in 283 aa overlap); Q9SW64|C7A10.320|AT4G37040 from Arabidopsis thaliana (Mouse-ear cress) (305 aa), FASTA scores: opt: 914, E(): 3e-49, (50.35% identity in 286 aa overlap); P07906|AMPM_ECOLI|MAP|B0168|Z0178|ECS0170 from Escherichia coli strains K12 and O157:H7 (264 aa), FASTA scores: opt: 793, E(): 8.5e-42, (51.0% identity in 245 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT. Note that this gene has an N-terminal extension present in the human map, but not in the prokaryotic map's. An alternative start, with RBS, will give a protein equivalent to the shorter prokaryotic map's. X2BLS3,P0A5J3 No NC_002945.3 Mycobrowser_v2 CDS 3130575 3131159 . - 0 Mb2887c CONSERVED HYPOTHETICAL PROTEIN Mb2887c, -, len: 194 aa. Equivalent to Rv2862c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 194 aa overlap). Conserved hypothetical protein, showing some similarity with others e.g. Q9X8X5|SCH35.31c HYPOTHETICAL 19.6 KDA PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 266,E(): 2.2e-11, (34.65% identity in 179 aa overlap); Q9Z5H1|ML0169|MLCB373.19 HYPOTHETICAL 22.1 KDA PROTEIN from Mycobacterium leprae (200 aa), FASTA scores: opt: 195, E(): 2.3e-06, (30.15% identity in 189 aa overlap); etc. Also some similarity to P71544|Y966_MYCTU|Rv0966c|MT0994|MTCY10D7.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (230 aa), FASTA scores: opt: 209, E(): 2.6e-07, (31.5% identity in 184 aa overlap). Q7TXP2 No conserved hypotheticals Rv2862c NC_002945.3 Mycobrowser_v2 CDS 3131317 3131511 . + 0 Mb2887A vapB23 Possible antitoxin VapB23 Mb2887A, len: 64 aa. Equivalent to Rv2862A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 64 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB23,antitoxin,part of toxin-antitoxin (TA) operon with Rv2863 (See Pandey and Gerdes, 2005). X2BLT8 No virulence, detoxification, adaptation Rv2862A NC_002945.3 Mycobrowser_v2 CDS 3131508 3131888 . + 0 Mb2888 vapc23 possible toxin vapc23 Mb2888, -, len: 126 aa. Equivalent to Rv2863, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Q50595|YI38_MYCTU|Rv1838c|MT1886|MTCY1A11.05|MTCY359.35 CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA scores: opt: 299, E(): 6.5e-15, (39.0% identity in 123 aa overlap). Q7TXP1 No virulence, detoxification, adaptation Rv2863 NC_002945.3 Mycobrowser_v2 CDS 3134053 3134334 . + 0 Mb2890 relf antitoxin relf Mb2890, -, len: 93 aa. Equivalent to Rv2865, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, showing weak similarity with P58235|YR54_SYNY3|SSR2754 HYPOTHETICAL 9.7 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (87 aa), FASTA scores: opt: 134, E(): 0.007, (30.65% identity in 75 aa overlap); BAB58570|SAV2408 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (83 aa),FASTA scores: opt: 124, E(): 0.037, (27.5% identity in 80 aa overlap). Also similar to Rv1247|MTV006.19c HYPOTHETICAL 9.8 KDA PROTEIN from Mycobacterium tuberculosis (89 aa), FASTA scores: opt: 249, E(): 2.6e-11, (44.2% identity in 86 aa overlap). Q7TXN9 No virulence, detoxification, adaptation Rv2865 NC_002945.3 Mycobrowser_v2 CDS 3138286 3139527 . - 0 Mb2895c dxr PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE) Mb2895c, dxr, len: 413 aa. Equivalent to Rv2870c,len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable dxr,1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.-), equivalent to Q9CBU3|DXR|ML1583 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE from Mycobacterium leprae (406 aa), FASTA scores: opt: 2145,E(): 1e-124, (84.05% identity in 395 aa overlap). Also highly similar to others e.g. Q9AJD7|DXR from Kitasatospora griseola (Streptomyces griseolosporeus) (386 aa), FASTA scores: opt: 1176, E(): 5.2e-65, (56.45% identity in 388 aa overlap); Q9KYS1|DXR_STRCO|SC5H4.18 from Streptomyces coelicolor (401 aa), FASTA scores: opt: 1079, E(): 5.1e-59, (52.25% identity in 396 aa overlap); P45568|DXR|B0173 from Escherichia coli strain K12 (398 aa), FASTA scores: opt: 120, E(): 0.032, (52.9% identity in 34 aa overlap); etc. Contains PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. BELONGS TO THE DXR FAMILY. N-terminus shortened since first submission. X2BLS9,P64013 No NC_002945.3 Mycobrowser_v2 CDS 3139898 3140341 . + 0 Mb2897 vapc43 possible toxin vapc43. contains pin domain. Mb2897, -, len: 147 aa. Equivalent to Rv2872, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein (see citation below), similar to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53683|Rv0277c|MTV035.05c (142 aa), FASTA scores: opt: 357, E(): 1.4e-17, (41.45% identity in 140 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 350,E(): 4.3e-17, (41.55% identity in 142 aa overlap); etc. X2BLV0,P65044 No virulence, detoxification, adaptation Rv2872 NC_002945.3 Mycobrowser_v2 CDS 3140421 3141083 . + 0 Mb2898 mpt83 cell surface lipoprotein mpt83 (lipoprotein p23) Mb2898, mpb83, len: 220 aa. Equivalent to Rv2873,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). mpt83 (alternate gene name: mpb83), cell surface lipoprotein (see citations below). Also similar to upstream ORF Q50769|MP70_MYCTU|MPT70|MPB70|Rv2875|MT2943|MTCY274.06 which is also known as MAJOR SECRETED IMMUNOGENIC PROTEIN MPT70 PRECURSOR from Mycobacterium tuberculosis (193 aa),FASTA scores: opt: 806, E(): 2.7e-38, (70.25% identity in 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FAMILY. ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR. X2BM94,P0CAX7 No NC_002945.3 Mycobrowser_v2 CDS 3141363 3143450 . + 0 Mb2899 dipZ POSSIBLE INTEGRAL MEMBRANE C-TYPE CYTOCHROME BIOGENESIS PROTEIN DIPZ Mb2899, dipZ, len: 695 aa. Equivalent to Rv2874,len: 695 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 695 aa overlap). Possible dipZ,cytochrome c-type biogenesis protein (see citation below),probable integral membrane protein, similar in part to others or hypothetical proteins e.g. CAC48606|SMB20213 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (627 aa), FASTA scores: opt: 844,E(): 7.3e-43, (32.65% identity in 643 aa overlap); Q9ZMH0|CCDA OR JHP0250 PUTATIVE CYTOCHROME C-TYPE BIOGENESIS PROTEIN from Helicobacter pylori J99 (Campylobacter pylori J99) (239 aa), FASTA scores: opt: 250, E(): 1.4e-07, (27.3% identity in 227 aa overlap); Q9LA04|CCDA C-TYPE CYTOCHROME BIOGENESIS PROTEIN from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (252 aa), FASTA scores: opt: 245, E(): 2.9e-07, (27.85% identity in 244 aa overlap); etc. Also similar to O06393|CCSA|Rv0527|MTCY25D10.06 CYTOCHROME C-TYPE BIOGENESIS PROTEIN from Mycobacterium tuberculosis (259 aa), FASTA scores: opt: 280, E(): 2.4e-09, (29.3% identity in 239 aa overlap). X2BMN3,P59960 No intermediary metabolism and respiration Rv2874 NC_002945.3 Mycobrowser_v2 CDS 3144179 3144493 . + 0 Mb2901 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb2901, -, len: 104 aa. Equivalent to Rv2876, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 104 aa overlap). Possible conserved transmembrane protein, equivalent (but longer 16 aa) to Q9CBU2|ML1584 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (84 aa), FASTA scores: opt: 444, E(): 8.3e-26, (73.85% identity in 88 aa overlap). Q7TXN4 No cell wall and cell processes Rv2876 NC_002945.3 Mycobrowser_v2 CDS 3207645 3212261 . + 0 Mb2957 ppsB PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Mb2957, ppsB, len: 1538 aa. Equivalent to Rv2932,len: 1538 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1538 aa overlap). ppsB, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE (1540 aa), FASTA scores: opt: 7284, E(): 0, (76.3% identity in 1561 aa overlap); Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE SYNTHASE (1446 aa), FASTA scores: opt: 6811, E(): 0, (76.2% identity in 1462 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. Q9KIZ6|EPOE EPOE PROTEIN from Polyangium cellulosum (3798 aa), FASTA scores: opt: 3052, E(): 3.3e-165, (38.35% identity in 1538 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10977|PPSA_MYCTU|RV2931 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FASTA scores: opt: 4227,E(): 0, (46.9% identity in 1810 aa overlap); P96203|PPSD|Rv2934|MTCY19H9.02 PKSE PROTEIN (1827 aa),FASTA scores: opt: 3756, E(): 1.8e-205, (42.9% identity in 1808 aa overlap); etc. Overlaps and extends CDS from neighbouring cosmid MTCY338.21. Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2932|ppsB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). X2BM25,Q7TXL9 No NC_002945.3 Mycobrowser_v2 CDS 3144524 3145387 . - 0 Mb2902c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2902c, -, len: 287 aa. Equivalent to Rv2877c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). Probable conserved integral membrane protein, Mer family possibly involved in transport of mercury, similar to others, and to the fourth protein of the mercury resistance operon of Streptomyces sp (or other organisms), and to putative cytochrome-c biogenesis proteins e.g. Q9XBD1|CZA382.20C PUTATIVE INTEGRAL MEMBRANE TRANSPORTER from Amycolatopsis orientalis (298 aa), FASTA scores: opt: 913, E(): 7.6e-46,(51.55% identity in 293 aa overlap); P30344|MER4_STRLI MERCURY RESISTANCE PROBABLE HG TRANSPORT PROTEIN from Streptomyces lividans (319 aa), FASTA scores: opt: 427,E(): 1.2e-17, (32.85% identity in 289 aa overlap); Q9M5P3 PUTATIVE CYTOCHROME C BIOGENESIS PROTEIN PRECURSOR from Arabidopsis thaliana (Mouse-ear cress) (354 aa), FASTA scores: opt: 229, E(): 4e-06, (29.85% identity in 221 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Note that previously known as merT. Q7TXN3 No cell wall and cell processes Rv2877c NC_002945.3 Mycobrowser_v2 CDS 3145392 3145913 . - 0 Mb2903c mpt53 soluble secreted antigen mpt53 precursor Mb2903c, mpb53, len: 173 aa. Equivalent to Rv2878c,len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 173 aa overlap). mpt53, secreted protein (contains N-terminal signal sequence) (see citations below). Shows some similarity with several disulfide bond interchange proteins e.g. P43787|THIX_HAEIN THIOREDOXIN-LIKE PROTEIN HI1115 from Haemophilus influenzae (167 aa), FASTA scores: opt: 200, E(): 1.4e-06,(28.9% identity in 135 aa overlap); P52237|TIPB_PSEFL THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR (CYTOCHROME C BIOGENESIS PROTEIN TIPB) (178 aa), FASTA scores: opt: 184, E(): 1.8e-05, (26.3% identity in 171 aa overlap); etc. Also highly similar to O53924|DSBF|Rv1677|MTV047.12 PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (182 aa), FASTA scores: opt: 482, E(): 5.7e-26, (52.8% identity in 142 aa overlap). COULD BE BELONG TO THE THIOREDOXIN FAMILY. Note that also previously known as dsbE. X2BMA0,P0A619 No NC_002945.3 Mycobrowser_v2 CDS 3146099 3147193 . - 0 Mb2904c CONSERVED HYPOTHETICAL PROTEIN Mb2904c, -, len: 364 aa. Equivalent to 5' end of Rv2880c and 3' end of Rv2879c, len: 275 aa and 189 aa,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 177 aa overlap and 100.0% identity in 188 aa overlap). Rv2880c: Conserved hypothetical protein, highly similar in N-terminus to others e.g. O86754|SC6A9.22c HYPOTHETICAL 40.4 KDA PROTEIN from Streptomyces coelicolor (368 aa), FASTA scores: opt: 663, E(): 2.6e-33, (52.6% identity in 213 aa overlap); Q55880|Y098_SYNY3|SLL0098 HYPOTHETICAL 38.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (350 aa), FASTA scores: opt: 362, E(): 7.3e-15, (38.9% identity in 162 aa overlap); O66732|AQ_416 HYPOTHETICAL 40.2 KDA PROTEIN from Aquifex aeolicus (348 aa), FASTA scores: opt: 321, E(): 2.4e-12, (39.75% identity in 146 aa overlap); etc. Appears to be a frame shift with respect to preceding ORF but we can detect no error in the cosmid sequence to account for this. Rv2879c: Conserved hypothetical protein, similar to others e.g. C-terminus of Q9RVT6|DR0936 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (346 aa), FASTA scores: opt: 505, E(): 1e-26, (46.5% identity in 185 aa overlap); O34617|YLON_BACSU HYPOTHETICAL 41.6 KDA PROTEIN from Bacillus subtilis (363 aa), FASTA scores: opt: 459, E(): 1.2e-24, (40.5% identity in 185 aa overlap); YFGB_ECOLI|P36979 hypothetical 43.1 kd protein from Escherichia coli (384 aa), FASTA scores, opt: 410, E(): 2.8e-21, (41.7% identity in 187 aa overlap); etc. Appears to be a frame shift with respect to following ORF but we can detect no error in the cosmid sequence to account for this. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2880c and Rv2879c exist as 2 genes. In Mycobacterium bovis, a single base deletion (g-*) leads to a single product. X2BMN8,P0A645 No NC_002945.3 Mycobrowser_v2 CDS 3147216 3148136 . - 0 Mb2905c cdsA PROBABLE INTEGRAL MEMBRANE PHOSPHATIDATE CYTIDYLYLTRANSFERASE CDSA (CDP-DIGLYCERIDE SYNTHETASE) (CDP-DIGLYCERIDE PYROPHOSPHORYLASE) (CDP-DIACYLGLYCEROL SYNTHASE) (CDS) (CTP:PHOSPHATIDATE CYTIDYLYLTRANSFERASE) (CDP-DAG SYNTHASE) (CDP-DG SYNTHETASE) Mb2905c, cdsA, len: 306 aa. Equivalent to Rv2881c,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 306 aa overlap). Probable cdsA,phosphatidate cytidylyltransferase (EC 2.7.7.41), integral membrane protein, equivalent to Q9CBU1|CDSA_MYCLE|ML1589 PHOSPHATIDATE CYTIDYLYLTRANSFERASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 1470, E(): 1.1e-84,(70.3% identity in 313 aa overlap). Also similar to others e.g. Q9KPV7|VC2255 from Vibrio cholerae (280 aa), FASTA scores: opt: 383, E(): 1.1e-16, (29.3% identity in 280 aa overlap); Q9CDT2|CDSA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (267 aa), FASTA scores: opt: 361, E(): 2.6e-15, (29.05% identity in 265 aa overlap); P06466|CDSA_ECOLI|CDS|B0175|Z0186|ECS0177 from Escherichia coli strains K12 and O157:H7 (249 aa), FASTA scores: opt: 352, E(): 9.2e-15, (40.4% identity in 156 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CDS FAMILY. X2BLT6,P63759 No NC_002945.3 Mycobrowser_v2 CDS 3156782 3157531 . + 0 Mb2915 CONSERVED HYPOTHETICAL PROTEIN Mb2915, -, len: 249 aa. Equivalent to Rv2891, len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Conserved hypothetical protein, similar in N-terminus to O69910|SC2E1.40c HYPOTHETICAL 22.8 KDA PROTEIN from Streptomyces coelicolor (226 aa), FASTA scores: opt: 315,E(): 3.4e-11, (40.7% identity in 145 aa overlap). C-terminus overlaps neigbouring ORF. X2BLU3 No conserved hypotheticals Rv2891 NC_002945.3 Mycobrowser_v2 CDS 3148159 3148716 . - 0 Mb2906c frr RIBOSOME RECYCLING FACTOR FRR (RIBOSOME RELEASING FACTOR) (RRF) Mb2906c, frr, len: 185 aa. Equivalent to Rv2882c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Probable frr,ribosome recycling factor, equivalent to O33046|RRF_MYCLE|FRR|ML1590|MLCB250.76 RIBOSOME RECYCLING FACTOR from Mycobacterium leprae (185 aa), FASTA scores: opt: 1063, E(): 2.6e-60, (90.8% identity in 185 aa overlap). Also highly similar to others e.g. O86770|RRF_STRCO|FRR|SC6A9.40c from Streptomyces coelicolor (185 aa), FASTA scores: opt: 783, E(): 1.5e-42,(63.25% identity in 185 aa overlap); P81101|RRF_BACSU|FRR from Bacillus subtilis (184 aa), FASTA scores: opt: 640,E(): 1.7e-33, (51.65% identity in 182 aa overlap); P16174|RRF_ECOLI|FRR|B0172|Z0183|ECS0174 from Escherichia coli strains K12 and O157:H7 (185 aa), FASTA scores: opt: 473, E(): 1.4e-23, (40.2% identity in 184 aa overlap); etc. BELONGS TO THE RRF FAMILY. X2BM41,P66735 No NC_002945.3 Mycobrowser_v2 CDS 3148888 3149673 . - 0 Mb2907c pyrH PROBABLE URIDYLATE KINASE PYRH (UK) (URIDINE MONOPHOSPHATE KINASE) (UMP KINASE) Mb2907c, pyrH, len: 261 aa. Equivalent to Rv2883c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable pyrH,uridylate kinase (EC 2.7.4.-), equivalent to O33045|PYRH_MYCLE|ML1591|MLCB250.75 URIDYLATE KINASE from Mycobacterium leprae (279 aa), FASTA scores: opt: 1437,E(): 3.8e-81, (85.05% identity in 274 aa overlap). Also highly similar to others e.g. O69913|PYRH from Streptomyces coelicolor (253 aa), FASTA scores: opt: 1086,E(): 1.4e-59, (68.9% identity in 251 aa overlap); P74457|PYRH_SYNY3|SLL0144 from Synechocystis sp. strain PCC 6803 (260 aa), FASTA scores: opt: 851, E(): 4.1e-45,(55.85% identity in 231 aa overlap); P29464|PYRH_ECOLI|SMBA|B0171|Z0182|ECS0173 from strains K12 and O157:H7 (240 aa), FASTA scores: opt: 666, E(): 1.1e-35, (45.7% identity in 232 aa overlap); etc. X2BLW4,P65930 No NC_002945.3 Mycobrowser_v2 CDS 3149908 3150666 . + 0 Mb2908 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb2908, -, len: 252 aa. Equivalent to Rv2884, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable transcriptional regulatory protein, highly similar to others e.g. Q05943|GLNR_STRCO|SCD84.26c TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (267 aa),FASTA scores: opt: 609, E(): 2.7e-34, (46.4% identity in 224 aa overlap); Q55733|SLL0396 REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM from Synechocystis sp. strain PCC 6803 (224 aa), FASTA scores: opt: 330, E(): 3e-15,(31.8% identity in 217 aa overlap); Q9A4S3|CC2757 DNA-BINDING RESPONSE REGULATOR from Caulobacter crescentus (223 aa), FASTA scores: opt: 311, E(): 6e-14, (30.3% identity in 221 aa overlap); etc. Also highly similar to O53830|Rv0818|MTV043.10 PUTATIVE REGULATORY PROTEIN from Mycobacterium tuberculosis (255 aa), FASTA scores: opt: 665, E(): 3.8e-38, (47.6% identity in 227 aa overlap). THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Q7TXN2 No regulatory proteins Rv2884 NC_002945.3 Mycobrowser_v2 CDS 3150745 3152064 . - 0 Mb2909c probable transposase Mb2909c, -, len: 439 aa. Equivalent to Rv2885c,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 437 aa overlap). Putative transposase for IS1539. Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (439 aa versus 460 aa). Q7TXN1 No insertion seqs and phages Rv2885c NC_002945.3 Mycobrowser_v2 CDS 3152061 3152948 . - 0 Mb2910c PROBABLE RESOLVASE Mb2910c, -, len: 295 aa. Equivalent to Rv2886c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Probable resolvase for IS1539. Contains PS00213 Lipocalin signature. X2BLT9,P65046 No insertion seqs and phages Rv2886c NC_002945.3 Mycobrowser_v2 CDS 3152947 3153366 . + 0 Mb2911 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb2911, -, len: 139 aa. Equivalent to Rv2887, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable transcriptional regulatory protein, highly similar to Q9EX59|SC1A4.04 PUTATIVE MARR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (151 aa), FASTA scores: opt: 354, E(): 6.6e-16, (42.95% identity in 135 aa overlap); and similar to others e.g. AAF97817|SLYA TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli strain EPEC 2348/69 (146 aa), FASTA scores: opt: 181, E(): 0.0001, (27.25% identity in 132 aa overlap); P55740|SLYA_ECOLI|AAG56631|B1642|Z2657|ECS2351 TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli strains K12 and O157:H7 (146 aa), FASTA scores: opt: 177,E(): 0.00018, (27.25% identity in 132 aa overlap) ; etc. Contains probable helix-turn-helix motif at aa 50-71 (Score 1182, +3.21 SD). X2BM43,P67748 No regulatory proteins Rv2887 NC_002945.3 Mycobrowser_v2 CDS 3153380 3154801 . - 0 Mb2912c amiC PROBABLE AMIDASE AMIC (AMINOHYDROLASE) Mb2912c, amiC, len: 473 aa. Equivalent to Rv2888c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 473 aa overlap). Probable amiC,amidase (EC 3.5.1.4), equivalent to O33040|AMI3_MYCLE|AMIC|ML1596|MLCB250.65 PUTATIVE AMIDASE AMIC from Mycobacterium leprae (468 aa), FASTA scores: opt: 2361, E(): 4.2e-139, (76.7% identity in 468 aa overlap). Also similar to others e.g. Q9A8N0|CC1323 PUTATIVE 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE from Caulobacter crescentus (521 aa), FASTA scores: opt: 925,E(): 7.4e-50, (36.55% identity in 465 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC 3.5.1.4) from Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 659, E(): 2.2e-33, (31.1% identity in 460 aa overlap); Q55424|AMID_SYNY3|SLL0828 PUTATIVE AMIDASE from Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores: opt: 643, E(): 2.4e-32, (30.7% identity in 466 aa overlap); etc. Also similar to O05835|AMI1_MYCTU|AMIA2|Rv2363|MT2432|MTCY27.17c PUTATIVE AMIDASE AMIA2 (484 aa), FASTA scores: opt: 656, E(): 3.6e-33, (35.9% identity in 465 aa overlap); and Q11056|AMI2_MYCTU|AMIB2|Rv1263|MT1301|MTCY50.19c PUTATIVE AMIDASE from Mycobacterium tuberculosis (462 aa), FASTA scores: opt: 650, E(): 8.2e-33, (33.45% identity in 472 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-poop). BELONGS TO THE AMIDASE FAMILY. X2BLX1,P63495 No NC_002945.3 Mycobrowser_v2 CDS 3154808 3155623 . - 0 Mb2913c tsf PROBABLE ELONGATION FACTOR TSF (EF-TS) Mb2913c, tsf, len: 271 aa. Equivalent to Rv2889c,len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 271 aa overlap). Probable tsf,elongation factor, equivalent to O33039|EFTS_MYCLE|TSF|ML1597|MLCB250.64 ELONGATION FACTOR from Mycobacterium leprae (276 aa), FASTA scores: opt: 1430, E(): 1.9e-80, (83.7% identity in 276 aa overlap). Also highly similar to others e.g. Q9X5Z9|EFTS_STRRA|TSF from Streptomyces ramocissimus (278 aa), FASTA scores: opt: 928, E(): 1.1e-49, (57.05% identity in 277 aa overlap); O31213|EFTS_STRCO|TSF|SC2E1.42 from Streptomyces coelicolor (278 aa), FASTA scores: opt: 927, E(): 1.3e-49,(56.3% identity in 277 aa overlap); P80700|EFTS_BACSU|TSF from Bacillus subtilis (292 aa), FASTA scores: opt: 650,E(): 1.3e-32, (43.85% identity in 276 aa overlap); etc. Contains PS01127 Elongation factor Ts signature 2. BELONGS TO THE EF-TS FAMILY. X2BMB3,Q7TXN0 No NC_002945.3 Mycobrowser_v2 CDS 3155635 3156498 . - 0 Mb2914c rpsB 30s ribosomal protein s2 rpsb Mb2914c, rpsB, len: 287 aa. Equivalent to Rv2890c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). Probable rpsB, 30s ribosomal protein s2, equivalent to O33038|RS2_MYCLE|RPSB|ML1598|MLCB250.63 30S RIBOSOMAL PROTEIN S2 from Mycobacterium leprae (277 aa), FASTA scores: opt: 1593, E(): 2.3e-93, (91.5% identity in 270 aa overlap). Also highly similar to others e.g. O31212|RS2_STRCO|RPSB|SC2E1.41 from Streptomyces coelicolor (310 aa), FASTA scores: opt: 1302, E(): 6.1e-75, (70.6% identity in 289 aa overlap); Q9KA63|RPSB|BH2427 from Bacillus halodurans (244 aa),FASTA scores: opt: 991, E(): 2.3e-55, (59.6% identity in 255 aa overlap); P21464|RS2_BACSU|RPSB from Bacillus subtilis (245 aa), FASTA scores: opt: 959, E(): 2.4e-53,(58.55% identity in 246 aa overlap); etc. Contains PS00962 Ribosomal protein S2 signature 1. BELONGS TO THE S2P FAMILY OF RIBOSOMAL PROTEINS. X2BMP8,P66538 No NC_002945.3 Mycobrowser_v2 CDS 3157310 3158536 . - 0 Mb2916c PPE45 ppe family protein ppe45 Mb2916c, PPE45, len: 408 aa. Equivalent to Rv2892c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O06386|Rv3621c|MTCY15C10.31|MTCY07H7B.01 from M. tuberculosis (413 aa), FASTA scores: opt: 957, E(): 6.2e-46, (44.7% identity in 423 aa overlap). X2BM47,P0A695 No NC_002945.3 Mycobrowser_v2 CDS 3158936 3159913 . + 0 Mb2917 POSSIBLE OXIDOREDUCTASE Mb2917, -, len: 325 aa. Equivalent to Rv2893, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 325 aa overlap). Possible oxidoreductase (EC 1.-.-.-), showing similarity with various proteins and/or oxidoreductases e.g. Q9AE05|RIF11 eleventh protein in the rif biosynthetic gene cluster from Amycolatopsis mediterranei (Nocardia mediterranei) (294 aa), FASTA scores: opt: 270, E(): 4.8e-10, (34.5% identity in 313 aa overlap); O52567 REDUCTASE from Amycolatopsis mediterranei (Nocardia mediterranei) (153 aa), FASTA scores: opt: 251, E(): 5e-09, (42.4% identity in 125 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 249, E(): 1.2e-08, (29.7% identity in 283 aa overlap); etc. Also some similarity with others proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. P71844|Rv0791c|MTCY369.35c PUTATIVE OXIDOREDUCTASE (347 aa), FASTA scores: opt: 264, E(): 1.3e-09, (29.05% identity in 272 aa overlap); and P96809|Rv0132|MTCI5.06c PUTATIVE OXIDOREDUCTASE (360 aa), FASTA scores: opt: 260,E(): 2.4e-09, (33.05% identity in 239 aa overlap). Q7TXM9 No intermediary metabolism and respiration Rv2893 NC_002945.3 Mycobrowser_v2 CDS 3159910 3160806 . - 0 Mb2918c xerC PROBABLE INTEGRASE/RECOMBINASE XERC Mb2918c, xerC, len: 298 aa. Equivalent to Rv2894c,len: 298 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 298 aa overlap). Probable xerC,integrase/recombinase, equivalent to Q9CBU0|XERC|ML1600|MLCB250.62 INTEGRASE/RECOMBINASE from Mycobacterium leprae (297 aa), FASTA scores: opt: 1624,E(): 2e-97, (85.15% identity in 296 aa overlap). Also highly similar to others integrases/recombinases (generally xerC and xerD) e.g. Q9HTS4|SSS|PA5280 SITE-SPECIFIC RECOMBINASE from Pseudomonas aeruginosa (303 aa), FASTA scores: opt: 660, E(): 3.2e-35, (41.8% identity in 299 aa overlap); Q9HXQ6|XERD|PA3738 INTEGRASE/RECOMBINASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 656, E(): 5.7e-35, (40.05% identity in 297 aa overlap); Q9KCP0|BH1529 INTEGRASE/RECOMBINASE from Bacillus halodurans (299 aa),FASTA scores: opt: 645, E(): 2.9e-34, (37.35% identity in 300 aa overlap); etc. Also similar to O33200|Rv1701|MTCI125.23 INTEGRASE/RECOMBINASE from Mycobacterium tuberculosis (311 aa), FASTA scores: opt: 646, E(): 2.6e-34, (43.1% identity in 304 aa overlap). BELONGS TO THE 'PHAGE' INTEGRASE FAMILY. X2BMB9,P67629 No NC_002945.3 Mycobrowser_v2 CDS 3160897 3161748 . - 0 Mb2919c viuB POSSIBLE MYCOBACTIN UTILIZATION PROTEIN VIUB Mb2919c, viuB, len: 283 aa. Equivalent to Rv2895c,len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Possible viuB,mycobactin utilization protein, highly similar to Q9RJ78|SCI41.06 HYPOTHETICAL 31.5 KDA PROTEIN from Streptomyces coelicolor (280 aa), FASTA scores: opt: 639,E(): 5.1e-32, (46.3% identity in 285 aa overlap); and similar to other proteins e.g. Q9F641|MXCB protein of the biosynthetic gene cluster of the myxochelin-type iron chelator from Stigmatella aurantiaca (270 aa), FASTA scores: opt: 417, E(): 2.2e-18, (34.2% identity in 263 aa overlap); Q56646|VIUB_VIBCH|VC2210 VIBRIOBACTIN UTILIZATION PROTEIN from Vibrio cholerae (271 aa), FASTA scores: opt: 395, E(): 5.1e-17, (31.0% identity in 274 aa overlap); Q56743|VIUB_VIBVU VULNIBACTIN UTILIZATION PROTEIN V from Vibrio vulnificus (271 aa), FASTA scores: opt: 390, E(): 1e-16, (33.95% identity in 274 aa overlap); etc. Equivalent to AAK47289 from Mycobacterium tuberculosis strain CDC1551 (321 aa) but shorter 38 aa. X2BMQ4,P65050 No NC_002945.3 Mycobrowser_v2 CDS 3187254 3187592 . - 0 Mb2943c glnB PROBABLE NITROGEN REGULATORY PROTEIN P-II GLNB Mb2943c, glnB, len: 112 aa. Equivalent to Rv2919c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Probable glnB,nitrogen regulatory protein, highly similar to others e.g. Q9X705|GLNB PII PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (112 aa), FASTA scores: opt: 531,E(): 4.5e-30, (68.75% identity in 112 aa overlap); P21193|GLNB_AZOBR NITROGEN REGULATORY PROTEIN P-II from Azospirillum brasilense (112 aa), FASTA scores: opt: 496,E(): 1.2e-27, (60.7% identity in 112 aa overlap); P05826|GLNB_ECOLI|B2553|Z3829|ECS3419|STY2808 NITROGEN REGULATORY PROTEIN P-II from Escherichia coli strains K12 and O157:H7 (112 aa), FASTA scores: opt: 487, E(): 5.3e-27, (61.6% identity in 112 aa overlap); etc. Contains PS00496 P-II protein urydylation site. BELONGS TO THE P(II) PROTEIN FAMILY. X2BMG6,P64250 No NC_002945.3 Mycobrowser_v2 CDS 3161781 3162950 . - 0 Mb2920c CONSERVED HYPOTHETICAL PROTEIN Mb2920c, -, len: 389 aa. Equivalent to Rv2896c,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 389 aa overlap). Conserved hypothetical protein, similar to others proteins e.g. Q9ZJ08|FIR2 from Rhodococcus fascians (293 aa), FASTA scores: opt: 663,E(): 3.3e-32, (43.7% identity in 286 aa overlap); O69892|SC2E1.21 HYPOTHETICAL 37.9 KDA PROTEIN from Streptomyces coelicolor (382 aa), FASTA scores: opt: 600,E(): 2.2e-28, (46.45% identity in 267 aa overlap); Q9JWZ4|DPRA|NMA0158 DPRA HOMOLOG from Neisseria meningitidis (serogroup A) (395 aa), FASTA scores: opt: 495, E(): 4.1e-22, (34.6% identity in 347 aa overlap); etc. Q7TXM8 No conserved hypotheticals Rv2896c NC_002945.3 Mycobrowser_v2 CDS 3162947 3164458 . - 0 Mb2921c CONSERVED HYPOTHETICAL PROTEIN Mb2921c, -, len: 503 aa. Equivalent to Rv2897c,len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Conserved hypothetical protein, possibly Mg-chelatase, highly similar to hypothetical proteins and chelatases e.g. Q9RTV0|DR1656 MG(2+) CHELATASE FAMILY PROTEIN from Deinococcus radiodurans (519 aa), FASTA scores: opt: 1333,E(): 3.6e-68, (46.55% identity in 505 aa overlap);Q55372|SLR0904 HYPOTHETICAL 55.1 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (509 aa), FASTA scores: opt: 1271, E(): 1.2e-64, (42.65% identity in 504 aa overlap); Q9HTR4|PA5290 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (497 aa), FASTA scores: opt: 1248,E(): 2.3e-63, (45.9% identity in 503 aa overlap); Q9K0Z6|COMM|NMB0405 COMPETENCE PROTEIN (MG-CHELATASE) from Neisseria meningitidis (serogroup B), FASTA scores: opt: 1229, E(): 2.8e-62, (43.2% identity in 509 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). X2BM50,P68908 No conserved hypotheticals Rv2897c NC_002945.3 Mycobrowser_v2 CDS 3164458 3164844 . - 0 Mb2922c CONSERVED HYPOTHETICAL PROTEIN Mb2922c, -, len: 128 aa. Equivalent to Rv2898c,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, highly similar to O33024|YS98_MYCLE|ML1607|MLCB250.49 HYPOTHETICAL 11.0 KDA PROTEIN from Mycobacterium leprae (96 aa), FASTA scores: opt: 318, E(): 2.3e-16, (58.35% identity in 96 aa overlap). Also similar to other hypothetical proteins e.g. O69890|YE19_STRCO|SC2E1.19 from Streptomyces coelicolor (130 aa), FASTA scores: opt: 253, E(): 1.7e-11, (39.65% identity in 121 aa overlap); Q9HVZ1|PA4424 from Pseudomonas aeruginosa (125 aa), FASTA scores: opt: 234,E(): 4.2e-10, (40.85% identity in 115 aa overlap); O86871 from Streptomyces lividans (85 aa), FASTA scores: opt: 224, E(): 1.8e-09, (46.45% identity in 84 aa overlap); etc. Equivalent to AAK47292 from Mycobacterium tuberculosis strain CDC1551 (141 aa) but shorter 13 aa. X2BLY4,P67231 No conserved hypotheticals Rv2898c NC_002945.3 Mycobrowser_v2 CDS 3165092 3165922 . - 0 Mb2923c fdhD possible fdhd protein homolog Mb2923c, fdhD, len: 276 aa. Equivalent to Rv2899c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Possible fdhD protein, highly similar to other bacterial fdhd proteins e.g. Q9ZBW0|FDHD_STRCO|SC4B5.08c from Streptomyces coelicolor (282 aa), FASTA scores: opt: 1032, E(): 3.6e-59, (59.0% identity in 278 aa overlap); BAB59387|TVG0258796 from Thermoplasma volcanium (279 aa),FASTA scores: opt: 536, E(): 3.4e-27, (38.65% identity in 282 aa overlap); Q9HL17|FDHD_THEAC|TA0423 from Thermoplasma acidophilum (282 aa), FASTA scores: opt: 529,E(): 9.6e-27, (38.8% identity in 281 aa overlap); P32177|FDHD_ECOLI FDHD PROTEIN from Escherichia coli strain K12 (277 aa), FASTA scores: opt: 297, E(): 8.6e-12,(33.35% identity in 261 aa overlap); etc. BELONGS TO THE FDHD FAMILY. X2BMC9,P64119 No NC_002945.3 Mycobrowser_v2 CDS 3165922 3168261 . - 0 Mb2924c fdhF POSSIBLE FORMATE DEHYDROGENASE H FDHF (FORMATE-HYDROGEN-LYASE-LINKED, SELENOCYSTEINE-CONTAINING POLYPEPTIDE) (FORMATE DEHYDROGENASE-H ALPHA SUBUNIT) (FDH-H) Mb2924c, fdhF, len: 779 aa. Equivalent to Rv2900c,len: 779 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 779 aa overlap). Possible fdhF,formate dehydrogenase (EC 1.2.1.2), highly similar to others formate dehydrogenases and prokaryotic molybdopterin-containing oxidoreductases e.g. Q9S2J9|SC7H2.18 PUTATIVE FORMATE DEHYDROGENASE from Streptomyces coelicolor (759 aa), FASTA scores: opt: 3038,E(): 2.7e-180, (59.7% identity in 767 aa overlap); Q9HU08|PA5181 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (773 aa), FASTA scores: opt: 2560, E(): 1.1e-150, (53.2% identity in 761 aa overlap); P78160 FORMATE DEHYDROGENASE A CHAIN (EC 1.2.1.2) (FRAGMENT) from Escherichia coli strain K12 (740 aa), FASTA scores: opt: 2002, E(): 3.7e-116, (43.1% identity in 733 aa overlap); P07658|FDHF_ECOLI|P78137|B4079 FORMATE DEHYDROGENASE from Escherichia coli strain K12 (715 aa), FASTA scores: opt: 305, E(): 5.6e-13, (25.5% identity in 748 aa overlap); etc. BELONGS TO THE PROKARYOTIC MOLYBDOPTERIN-CONTAINING OXIDOREDUCTASE FAMILY. X2BMQ9,P65409 No NC_002945.3 Mycobrowser_v2 CDS 3168319 3168624 . - 0 Mb2925c conserved protein Mb2925c, -, len: 101 aa. Equivalent to Rv2901c,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Conserved hypothetical protein, very equivalent to O33023|ML1610|MLCB250.41 HYPOTHETICAL 12.3 KDA PROTEIN from Mycobacterium leprae (101 aa), FASTA scores: opt: 658, E(): 2.6e-43, (99.0% identity in 101 aa overlap). Also highly similar to O69889|SC2E1.18 HYPOTHETICAL PROTEIN from Streptomyces coelicolor and Streptomyces lividans (102 aa), FASTA scores: opt: 515, E(): 2.2e-32,(75.0% identity in 100 aa overlap). X2BLU8 No conserved hypotheticals Rv2901c NC_002945.3 Mycobrowser_v2 CDS 3168678 3169472 . - 0 Mb2926c rnhB PROBABLE RIBONUCLEASE HII PROTEIN RNHB (RNASE HII) Mb2926c, rnhB, len: 264 aa. Equivalent to Rv2902c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable rnhB,ribonuclease HII (EC 3.1.26.4), equivalent to O33022|RNH2_MYCLE|RNHB|ML1611|MLCB250.40 RIBONUCLEASE HII from Mycobacterium leprae (240 aa), FASTA scores: opt: 1242, E(): 6.9e-72, (76.75% identity in 245 aa overlap). Also similar (but longer ~20 aa) to others e.g. Q9HXY9|RNHB|PA3642 RIBONUCLEASE HII from Pseudomonas aeruginosa (201 aa), FASTA scores: opt: 572, E(): 3.1e-29,(52.7% identity in 184 aa overlap); Q9PEI7|RNH2_XYLFA|RNHB|XF1041 RIBONUCLEASE HII from Xylella fastidiosa (234 aa), FASTA scores: opt: 556, E(): 3.6e-28, (50.25% identity in 185 aa overlap); P10442|RNH2_ECOLI|RNHB|B0183 RIBONUCLEASE HII from Escherichia coli strain K-12 (213 aa), FASTA scores: opt: 519, E(): 7.4e-26, (48.65% identity in 183 aa overlap); etc. BELONGS TO THE RNASE HII FAMILY. COFACTOR: MANGANESE (BY SIMILARITY). X2BM53,Q7TXM7 No NC_002945.3 Mycobrowser_v2 CDS 3169486 3170370 . - 0 Mb2927c lepB PROBABLE SIGNAL PEPTIDASE I LEPB (SPASE I) (LEADER PEPTIDASE I). Mb2927c, lepB, len: 294 aa. Equivalent to Rv2903c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 294 aa overlap). Probable lepB, signal peptidase I (EC 3.4.21.89) (TYPE II MEMBRANE PROTEIN) (see first citation below), equivalent to O33021|LEP_MYCLE|ML1612|MLCB250.39 PROBABLE SIGNAL PEPTIDASE I from Mycobacterium leprae (289 aa), FASTA scores: opt: 1335, E(): 1.8e-77, (69.75% identity in 301 aa overlap). Also similar to many e.g. O86869|SIPX SIGNAL PEPTIDASE I from Streptomyces lividans (320 aa), FASTA scores: opt: 474, E(): 1e-22, (43.55% identity in 248 aa overlap); O69884|SIP1|SIPW PUTATIVE SIGNAL PEPTIDASE I from Streptomyces coelicolor and Streptomyces lividans (259 aa), FASTA scores: opt: 226, E(): 5e-07, (36.0% identity in 214 aa overlap); P42668|LEP_BACLI|SIP SIGNAL PEPTIDASE I from Bacillus licheniformis (186 aa), FASTA scores: opt: 218, E(): 1.3e-06, (34.5% identity in 194 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site,and PS00761 Signal peptidases I signature 3. BELONGS TO PEPTIDASE FAMILY S26; ALSO KNOWN AS TYPE I LEADER PEPTIDASE FAMILY. Q7TXM6 No NC_002945.3 Mycobrowser_v2 CDS 3172181 3172873 . - 0 Mb2930c trmD PROBABLE TRNA (GUANINE-N1)-METHYLTRANSFERASE TRMD (M1G-METHYLTRANSFERASE) (TRNA [GM37] METHYLTRANSFERASE) Mb2930c, trmD, len: 230 aa. Equivalent to Rv2906c,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Probable trmD, tRNA m1G methyltransferase (EC 2.1.1.31), equivalent to O33017|TRMD_MYCLE from Mycobacterium leprae (238 aa),FASTA scores: opt: 1363, E(): 8.1e-86, (87.2% identity in 227 aa overlap). Also highly similar to others e.g. O69882|TRMD_STRCO from Streptomyces coelicolor and S. lividans (277 aa), FASTA scores: opt: 841, E(): 4.5e-50,(55.55% identity in 234 aa overlap); Q9A0B6 from Streptococcus pyogenes (243 aa), FASTA scores: opt: 698,E(): 2.5e-40, (47.6% identity in 227 aa overlap); P07020|TRMD_ECOLI|TRMD|B2607|Z3901|ECS3470 from Escherichia coli strain O157:H7 (255 aa), FASTA scores: opt: 573, E(): 3.8e-33, (42.1% identity in 228 aa overlap); etc. BELONGS TO THE RNA METHYLTRANSFERASE TRMD FAMILY. X2BLV2,P66969 No NC_002945.3 Mycobrowser_v2 CDS 3170428 3170769 . - 0 Mb2928c rplS 50s ribosomal protein l19 rpls Mb2928c, rplS, len: 113 aa. Equivalent to Rv2904c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Probable rplS, 50S ribosomal protein L19, equivalent to O33020|RL19_MYCLE 50S RIBOSOMAL PROTEIN L19 from Mycobacterium leprae (113 aa),FASTA scores: opt: 702, E(): 1.4e-45, (93.8% identity in 113 aa overlap). Also highly similar to others e.g. O69883|RL19_STRCO from Streptomyces coelicolor (116 aa),FASTA scores: opt: 571, E(): 9.5e-36, (77.25% identity in 110 aa overlap); O31742|RL19_BACSU from Bacillus subtilis (115 aa), FASTA scores: opt: 523, E(): 3.8e-32, (72.9% identity in 107 aa overlap); RL19_BACST|P30529 from Bacillus stearothermophilus (116 aa), FASTA scores: opt: 518, E(): 9.1e-32, (71.7% identity in 106 aa overlap); etc. BELONGS TO THE L19P FAMILY OF RIBOSOMAL PROTEINS. X2BMD7,P66081 No NC_002945.3 Mycobrowser_v2 CDS 3176379 3178214 . - 0 Mb2937c possible d-amino acid aminohydrolase (d-amino acid hydrolase) Mb2937c, -, len: 611 aa. Equivalent to Rv2913c,len: 611 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 611 aa overlap). Possible D-amino acid aminohydrolase (EC 3.5.1.-), similar (principally in N-terminus) to D-amino acid aminohydrolases e.g. Q9V2D3|NDAD|PAB0090 D-AMINOACYLASE (ASPARTATE, GLUTAMATE ETC) from Pyrococcus abyssi (526 aa), FASTA scores: opt: 336, E(): 2.2e-13, (27.55% identity in 581 aa overlap); P94212|NDDD_ALCXX N-ACYL-D-ASPARTATE DEACYLASE (EC 3.5.1.83) (N-ACYL-D-ASPARTATE AMIDOHYDROLASE) from Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans) (498 aa), FASTA scores: opt: 221, E(): 3.4e-06, (25.95% identity in 532 aa overlap); Q9AGH8 D-AMINOACYLASE (EC 3.5.1.81) from Alcaligenes faecalis (484 aa), FASTA scores: opt: 218, E(): 5.1e-06, (28.35% identity in 434 aa overlap); etc. X2BLZ8,P65531 No intermediary metabolism and respiration Rv2913c NC_002945.3 Mycobrowser_v2 CDS 3620343 3620774 . + 0 Mb3312 CONSERVED HYPOTHETICAL PROTEIN Mb3312, -, len: 143 aa. Equivalent to Rv3284, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein, with similarity to other bacterial hypothetical proteins e.g. Q9RXU0|DR0216 from Deinococcus radiodurans (147 aa), FASTA scores: opt: 425, E(): 9.1e-21, (46.55% identity in 146 aa overlap); BAB37094|ECS3671 from Escherichia coli strain O157:H7 (147 aa), FASTA scores: opt: 187, E(): 2.2e-05, (29.5% identity in 139 aa overlap); AAG57925|YGDK from Escherichia coli strain O157:H7 EDL933 (147 aa), FASTA scores: opt: 187,E(): 2.2e-05, (32.05% identity in 139 aa overlap); etc. X2BN24 No conserved hypotheticals Rv3284 NC_002945.3 Mycobrowser_v2 CDS 3171144 3172088 . + 0 Mb2929 lppW PROBABLE CONSERVED ALANINE RICH LIPOPROTEIN LPPW Mb2929, lppW, len: 314 aa. Equivalent to Rv2905,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable lppW,conserved ala-rich lipoprotein, with slight similarity to beta-lactamases and hypothetical proteins e.g. Q9S1P7|SCJ9A.23 HYPOTHETICAL 36.3 KDA PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 222,E(): 2.8e-06, (25.5% identity in 298 aa overlap); O69914|SC3C8.01 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (302 aa), FASTA scores: opt: 201,E(): 5.1e-05, (24.9% identity in 257 aa overlap); P14559|BLAC_STRAL BETA-LACTAMASE PRECURSOR from Streptomyces albus G (314 aa), FASTA scores: opt: 113,E(): 3.3, (25.2% identity in 278 aa overlap); etc. Has signal peptide and appropriately positioned prokaryotic lipoprotein lipid attachment site: ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR (POTENTIAL). X2BMR5,P65305 No cell wall and cell processes Rv2905 NC_002945.3 Mycobrowser_v2 CDS 3199543 3199854 . + 0 Mb2954 HYPOTHETICAL PROTEIN Mb2954, -, len: 103 aa. Equivalent to Rv2929, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Hypothetical unknown protein; unlikely ORF but some weak similarity to C-terminal half of P18319|UREG_KLEAE urease accessory protein from klebsiella aerogenes (205 aa), FASTA scores: opt: 99, E(): 1.1, (38.6% identity in 57 aa overlap). X2BMU1 No conserved hypotheticals Rv2929 NC_002945.3 Mycobrowser_v2 CDS 3172877 3173407 . - 0 Mb2931c rimM PROBABLE 16S RRNA PROCESSING PROTEIN RIMM Mb2931c, rimM, len: 176 aa. Equivalent to Rv2907c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Probable rimM, 16S rRNA processing protein, equivalent to O33016|RIMM_MYCLE PROBABLE 16S RRNA PROCESSING protein from Mycobacterium leprae (179 aa), FASTA scores: opt: 797, E(): 2.4e-46,(73.15% identity in 175 aa overlap). Also highly similar to others e.g. O69881|RIMM_STRCO from Streptomyces coelicolor (188 aa), FASTA scores: opt: 485, E(): 2.3e-25,(48.85% identity in 176 aa overlap); Q9KA14|RIMM_BACHD from Bacillus halodurans (173 aa), FASTA scores: opt: 289,E(): 3.2e-12, (30.65% identity in 173 aa overlap); P21504|RIMM_ECOLI|RIMM|B2608 from Escherichia coli strain K12 (182 aa), FASTA scores: opt: 237, E(): 1e-08, (29.4% identity in 177 aa overlap). BELONGS TO THE RIMM FAMILY. X2BM56,P66654 No NC_002945.3 Mycobrowser_v2 CDS 3173421 3173663 . - 0 Mb2932c CONSERVED HYPOTHETICAL PROTEIN Mb2932c, -, len: 80 aa. Equivalent to Rv2908c, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Conserved hypothetical protein, equivalent to O33015|YT08_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 492, E(): 3.1e-29, (93.75% identity in 80 aa overlap). Also highly similar to others e.g. O69880|YE09_STRCO from Streptomyces coelicolor (79 aa), FASTA scores: opt: 356, E(): 3e-19,(71.6% identity in 74 aa overlap); Q9KA12|BH2482 PROTEIN from Bacillus halodurans (76 aa), FASTA scores: opt: 220,E(): 2.9e-09, (48.6% identity in 72 aa overlap); O31738|YLQC_BACSU HYPOTHETICAL 9.1 KDA PROTEIN from Bacillus subtilis (81 aa), FASTA scores: opt: 172, E(): 1e-05, (39.2% identity in 74 aa overlap); etc. BELONGS TO THE UPF0109 FAMILY. X2BLZ3,P67237 No conserved hypotheticals Rv2908c NC_002945.3 Mycobrowser_v2 CDS 3173671 3174159 . - 0 Mb2933c rpsP 30s ribosomal protein s16 rpsp Mb2933c, rpsP, len: 162 aa. Equivalent to Rv2909c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Probable rpsP, 30S ribosomal protein S16, equivalent to O33014|RS16_MYCLE 30S RIBOSOMAL PROTEIN S16 from Mycobacterium leprae (160 aa),FASTA scores: opt: 828, E(): 1.6e-39, (82.5% identity in 160 aa overlap). Also highly similar to others e.g. O69879|RS16_STRCO 30S RIBOSOMAL PROTEIN S16 from Streptomyces coelicolor (139 aa), FASTA scores: opt: 486,E(): 1.9e-20, (56.95% identity in 144 aa overlap); P80379|RS16_THETH 30S RIBOSOMAL PROTEIN S16 from Thermus Thermophilus (88 aa), FASTA scores: opt: 280, E(): 4.8e-09, (53.25% identity in 77 aa overlap) (C-terminus shorter); P21474|RS16_BACSU|RPSP 30S RIBOSOMAL PROTEIN S16 (BS17) from Bacillus subtilis (89 aa,), FASTA scores: opt: 258, E(): 8.2e-08, (42.85% identity in 91 aa overlap) (C-terminus shorter); etc. BELONGS TO THE S16P FAMILY OF RIBOSOMAL PROTEINS. X2BME7,P66436 No NC_002945.3 Mycobrowser_v2 CDS 3174343 3174786 . - 0 Mb2934c CONSERVED HYPOTHETICAL PROTEIN Mb2934c, -, len: 147 aa. Equivalent to Rv2910c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein, showing some similarity with hypothetical proteins from other organisms e.g. Q9JN76|MMYY HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 164,E(): 0.00026, (35.05% identity in 129 aa overlap); etc. Also some similarity with protein from Mycobacterium tuberculosis e.g. O07237|Rv0310c|MTCY63.15c (163 aa),FASTA scores: opt: 165, E(): 0.00023, (26.3% identity in 137 aa overlap); P96815|Rv0138|MTCI5.12 (167 aa), FASTA scores: opt: 132, E(): 0.048, (30.25% identity in 109 aa overlap); etc. X2BMR9 No conserved hypotheticals Rv2910c NC_002945.3 Mycobrowser_v2 CDS 3174855 3175730 . + 0 Mb2935 dacB2 probable penicillin-binding protein dacb2 (d-alanyl-d-alanine carboxypeptidase) (dd-peptidase) (dd-carboxypeptidase) (pbp) (dd-transpeptidase) (serine-type d-ala-d-ala carboxypeptidase) (d-amino acid hydrolase) Mb2935, dacB2, len: 291 aa. Equivalent to Rv2911,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Probable dacB2,D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), an ala-rich protein. Highly similar (except in N-terminus) to Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 749, E(): 9.3e-39,(46.75% identity in 276 aa overlap). Also similar to penicillin binding proteins / D-alanyl-D-alanine carboxypeptidases e.g. Q9KCJ8|SC4G1.16c D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (382 aa),FASTA scores: opt: 386, E(): 2.1e-16, (31.25% identity in 285 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR from Bacillus subtilis (382 aa),FASTA scores: opt: 384, E(): 3.6e-17, (30.7% identity in 244 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN 5) from Bacillus halodurans (395 aa), FASTA scores: opt: 359, E(): 9.7e-15, (30.3% identity in 241 aa overlap); P33364|PBP7_ECOLI|PBPG|B2134 penicillin-binding protein 7 precursor from Escherichia coli strain K12 (313 aa), FASTA scores: opt: 273, E(): 7.5e-10, (27.8% identity in 263 aa overlap); etc. Also similar to O53380|Rv3330|MTV016.30 PENICILLIN-BINDING PROTEIN from Mycobacterium tuberculosis (405 aa), FASTA scores: opt: 746, E(): 1.4e-38, (47.0% identity in 266 aa overlap). Seems to contain PF00768 Peptidase_S11 domain PFAM. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY. Thought to be a membrane-bound protein. Note that previously known as dacB. Q7TXM5 No NC_002945.3 Mycobrowser_v2 CDS 3175790 3176377 . - 0 Mb2936c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb2936c, -, len: 195 aa. Equivalent to Rv2912c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). Probable transcription regulatory protein, tetR family, showing similarity with others e.g. Q9K3V9|SCD10.17 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (202 aa), FASTA scores: opt: 185, E(): 4.4e-05, (31.15% identity in 167 aa overlap); Q9KFQ0 TETR-FAMILY from Bacillus halodurans (185 aa), FASTA scores: opt: 164, E(): 0.001, (35.6% identity in 73 aa overlap); P17446|BETI_ECOLI|BETI|B0313 regulatory protein from Escherichia coli strain K12 (195 aa), FASTA scores: opt: 126, E(): 0.024, (24.5% identity in 196 aa overlap); etc. Contains possible helix-turn-helix motif at aa 33-54 (+2.71 SD). POSSIBLY BELONGS TO THE TETR/ACRR FAMILY. X2BM59,P67441 No regulatory proteins Rv2912c NC_002945.3 Mycobrowser_v2 CDS 3218821 3224304 . + 0 Mb2959 ppsD PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Mb2959, ppsD, len: 1827 aa. Equivalent to Rv2934,len: 1827 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1827 aa overlap). ppsD, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9CB70|ML2354 POLYKETIDE SYNTHASE (1822 aa), FASTA scores: opt: 9779,E(): 0, (80.35% identity in 1836 aa overlap); Q49940|L518_F3_67|PFSE (1815 aa), FASTA scores: opt: 9658,E(): 0, (79.85% identity in 1831 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9RNB2|MCYD|Q9FDU1 POLYKETIDE SYNTHASE (MCYD PROTEIN) from Microcystis aeruginosa (3906 aa), FASTA scores: opt: 2961, E(): 6e-159, (32.15% identity in 1827 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1538 aa),FASTA scores: opt: 3756, E(): 3.8e-204, (42.85% identity in 1808 aa overlap) (gaps in middle); P96202|PPSC|RV2933 POLYKETIDE SYNTHASE (2188 aa), FASTA scores: opt: 3463,E(): 1.7e-187, (39.2% identity in 2165 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site,PS00017 ATP/GTP-binding site motif A, PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS00012 Phosphopantetheine attachment site. Note that Rv2934|ppsD belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). X2BMU6,Q7TXL7 No NC_002945.3 Mycobrowser_v2 CDS 3178283 3180040 . - 0 Mb2938c pknI PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKNI (PROTEIN KINASE I) (STPK I) (PHOSPHORYLASE B KINASE KINASE) (HYDROXYALKYL-PROTEIN KINASE) Mb2938c, pknI, len: 585 aa. Equivalent to Rv2914c,len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 585 aa overlap). Probable pknI,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), ala-rich protein, highly similar to many in Mycobacterium tuberculosis and other bacteria e.g. Q9RLQ7|MBK PUTATIVE SERINE/THREONINE PROTEIN KINASE from Mycobacterium bovis BCG (291 aa), FASTA scores: opt: 376,E(): 1.1e-10, (36.95% identity in 287 aa overlap); P33973|PKN1_MYXXA serine/threonine-protein kinase from Myxococcus xanthus (693 aa), FASTA scores: opt: 286, E(): 5.4e-10, (29.9% identity in 374 aa overlap); P72003|PKNF_MYCTU|Rv1746|MT1788|MTCY28.09 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis (476 aa), FASTA scores: opt: 675, E(): 1.7e-24, (39.75% identity in 468 aa overlap); Q10697|PKNJ_MYCTU|Rv2088|MT2149|MTCY49.28 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis (589 aa), FASTA scores: opt: 574, E(): 1e-19,(34.85% identity in 479 aa overlap); etc. Equivalent to AAK47308 from Mycobacterium tuberculosis strain CDC1551 (603 aa) but shorter 18 aa. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. X2BMF5,P65731 No NC_002945.3 Mycobrowser_v2 CDS 3196402 3197124 . - 0 Mb2950c rnc PROBABLE RIBONUCLEASE III RNC (RNASE III) Mb2950c, rnc, len: 240 aa. Equivalent to Rv2925c,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable rnc,ribonuclease III (RNase III) (EC 3.1.26.3), equivalent to O69469|RNC_MYCLE RIBONUCLEASE III from Mycobacterium leprae (238 aa). Also highly similar to other ribonucleases III e.g. Q9ZBQ7|RNC_STRCO from Streptomyces coelicolor (272 aa), FASTA scores: opt: 889, E(): 5.4e-51,(62.2% identity in 225 aa overlap) (N-terminus longer 21 aa); P51833|RNC_BACSU from Bacillus subtilis (249 aa),FASTA scores: opt: 493, E(): 5e-25, (43.25% identity in 215 aa overlap); P05797|RNC_ECOLI|RNC|B2567|Z3848|ECS3433 from Escherichia coli strain O157:H7 and K12 (226 aa),FASTA scores: opt: 459, E(): 7.9e-23, (41.8% identity in 213 aa overlap); etc. Contains PS00517 Ribonuclease III family signature. X2BLW8,P66667 No NC_002945.3 Mycobrowser_v2 CDS 3180084 3181196 . - 0 Mb2939c conserved protein Mb2939c, -, len: 370 aa. Equivalent to Rv2915c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 370 aa overlap). Conserved hypothetical protein, posssibly XAA-PRO dipeptidase (prolidase) (EC 3.4.13.9), highly similar to CAC38796|SCI39.08c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (363 aa), FASTA scores: opt: 1341,E(): 5.5e-76, (56.65% identity in 362 aa overlap); and similar to prolidases (XAA-PRO dipeptidase) e.g. Q9ABC9|CC0300 PUTATIVE XAA-PRO DIPEPTIDASE from Caulobacter crescentus (428 aa), FASTA scores: opt: 327,E(): 7.4e-13, (30.2% identity in 374 aa overlap); Q97XD4 PROLIDASE from Sulfolobus solfataricus (396 aa), FASTA scores: opt: 271, E(): 2.1e-09, (30.5% identity in 354 aa overlap); Q9WX55 PROLIDASE from Microbacterium esteraromaticum (393 aa), FASTA scores: opt: 256, E(): 1.8e-08, (27.95% identity in 365 aa overlap); etc. Also similar to O53619|Rv0074|MTV030.18 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (411 aa), FASTA scores: opt: 243, E(): 1.2e-07, (27.5% identity in 389 aa overlap). X2BMS4 No conserved hypotheticals Rv2915c NC_002945.3 Mycobrowser_v2 CDS 3181224 3182801 . - 0 Mb2940c ffh probable signal recognition particle protein ffh (fifty-four homolog) (srp protein) Mb2940c, ffh, len: 525 aa. Equivalent to Rv2916c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable ffh, signal recognition particle protein (ala-, gly-, leu-rich protein), equivalent to O33013|SR54_MYCLE SIGNAL RECOGNITION PARTICLE from Mycobacterium leprae (521 aa),FASTA scores: opt: 2968, E(): 1.6e-145, (87.85% identity in 526 aa overlap). Also highly similar to others e.g. O69874|FFH from Streptomyces coelicolor (550 aa), FASTA scores: opt: 2025, E(): 6e-97, (63.8% identity in 519 aa overlap) (N-terminus longer 34 aa); P37105|SR54_BACSU from Bacillus subtilis (446 aa), FASTA scores: opt: 1451, E(): 1.9e-67, (51.5% identity in 435 aa overlap); BAB57399|FFH from Staphylococcus aureus subsp. aureus Mu50 (455 aa),FASTA scores: opt: 1418, E(): 9.4e-66, (48.65% identity in 448 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SRP FAMILY OF GTP-BINDING PROTEINS. NOTE THAT SIGNAL RECOGNITION PARTICLE CONSISTS OF A SMALL CYTOPLASMIC RNA (SC-RNA) MOLECULE AND PROTEIN FFH. THE PROTEIN HAS A TWO DOMAIN STRUCTURE: THE G-DOMAIN BINDS GTP; THE M-DOMAIN BINDS THE RNA AND ALSO BINDS THE SIGNAL SEQUENCE. X2BLW0,P66845 No NC_002945.3 Mycobrowser_v2 CDS 3424153 3424473 . + 0 Mb3125A PemK-like protein Mb3125A, len: 106 aa. Equivalent to Rv3098A len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 106 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). PemK-like protein. X2BN25 No virulence, detoxification, adaptation Rv3098A NC_002945.3 Mycobrowser_v2 CDS 3182879 3184759 . + 0 Mb2941 CONSERVED HYPOTHETICAL ALANINE AND ARGININE RICH PROTEIN Mb2941, -, len: 626 aa. Equivalent to Rv2917, len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 626 aa overlap). Conserved hypothetical ala-, arg-rich protein, highly similar (but longer 34 aa) to O33011|ML1624|MLCB250.18C HYPOTHETICAL 65.2 KDA PROTEIN from Mycobacterium leprae (596 aa), FASTA scores: opt: 3117, E(): 9e-183, (79.8% identity in 584 aa overlap). Also highly similar to Q9S2E8|SCE19A.36C HYPOTHETICAL 66.2 KDA PROTEIN from Streptomyces coelicolor (598 aa), FASTA scores: opt: 1921, E(): 1.1e-109, (56.08% identity in 567 aa overlap); and Q9S3Y6|SDRA SDRA PROTEIN from Streptomyces coelicolor (597 aa), FASTA scores: opt: 1896,E(): 3.6e-108, (55.75% identity in 567 aa overlap). And shows some similarity with others proteins from other organisms. Equivalent to AAK47311 putative RNA helicase from Mycobacterium tuberculosis strain CDC1551 (602 aa) but longer 24 aa. Contains PS00017 ATP/GTP-binding site motif (P-loop). Q7TXM4 No conserved hypotheticals Rv2917 NC_002945.3 Mycobrowser_v2 CDS 3184770 3187196 . - 0 Mb2942c glnD PROBABLE [PROTEIN-PII] URIDYLYLTRANSFERASE GLND (PII URIDYLYL-TRANSFERASE) (URIDYLYL REMOVING ENZYME) (UTASE) Mb2942c, glnD, len: 808 aa. Equivalent to Rv2918c,len: 808 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 808 aa overlap). Probable glnD,uridylyltransferase (ala-rich protein) (EC 2.7.7.59),similar to other uridylyltransferases e.g. O69873||SC2E1.02 from Streptomyces coelicolor (835 aa),FASTA scores: opt: 1473, E(): 2.8e-81, (41.03% identity in 858 aa overlap); P43919|GLND_HAEIN from Haemophilus influenzae (863 aa), FASTA scores: opt: 333, E(): 2.5e-12,(25.4% identity in 819 aa overlap); P27249|GLND_ECOLI|GLND|B0167 from Escherichia coli strain K12 (890 aa), FASTA scores: opt: 306, E(): 1.1e-10,(27.75% identity in 858 aa overlap); etc. BELONGS TO THE GLND FAMILY. Q7TXM3 No NC_002945.3 Mycobrowser_v2 CDS 3187589 3189022 . - 0 Mb2944c amt PROBABLE AMMONIUM-TRANSPORT INTEGRAL MEMBRANE PROTEIN AMT Mb2944c, amt, len: 477 aa. Equivalent to Rv2920c,len: 477 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 477 aa overlap). Probable amt,ammonium-transport integral membrane protein (ala-, gly-,leu-, val-rich protein), highly similar to others e.g. Q9ZBP6|SC7A1.27 AMMONIUM TRANSPORTER from Streptomyces coelicolor (448 aa), FASTA scores: opt: 1246, E(): 7.3e-67, (54.1% identity in 462 aa overlap); P54146|AMT_CORGL AMMONIUM TRANSPORT SYSTEM from Corynebacterium glutamicum (452 aa), FASTA scores: opt: 953, E(): 2.1e-49, (41.45% identity in 475 aa overlap); Q07429|NRGA_BACSU PROBABLE AMMONIUM TRANSPORTER (MEMBRANE PROTEIN NRGA) from Bacillus subtilis (404 aa), FASTA scores: opt: 721, E(): 0, (44.4% identity in 430 aa overlap); etc. BELONGS TO THE AMT1/MEP/NRGA FAMILY OF AMMONIUM TRANSPORTERS (TC 2.49). X2BMS9,P63520 No NC_002945.3 Mycobrowser_v2 CDS 3189499 3190767 . - 0 Mb2945c ftsY probable cell division protein ftsy (srp receptor) (signal recognition particle receptor) Mb2945c, ftsY, len: 422 aa. Equivalent to Rv2921c,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Probable ftsY,membrane-associated cell division protein, equivalent to O33010|FTSY_MYCLE CELL DIVISION PROTEIN FTSY HOMOLOG from Mycobacterium leprae (430 aa), FASTA scores: opt: 1760,E(): 1.1e-108, (81.35% identity in 429 aa overlap). Also similar to others e.g. Q9I6C1|FTSY|PA0373 SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY from Pseudomonas aeruginosa (455 aa), FASTA scores: opt: 882, E(): 5.1e-40,(42.08% identity in 385 aa overlap); Q9KVJ6|FTSY CELL DIVISION PROTEIN from Vibrio cholerae (391 aa), FASTA scores: opt: 837, E(): 1.2e-37, (36.3% identity in 394 aa overlap); P10121|FTSY_ECOLI|FTSY|B3464 CELL DIVISION PROTEIN from Escherichia coli strain K12 (497 aa), FASTA scores: opt: 800, E(): 1.3e-35, (39.75% identity in 327 aa overlap); etc. Also similar to Q9ZBP9|SC7A1.24 PUTATIVE PROKARYOTIC DOCKING PROTEIN from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1461, E(): 4.3e-71, (60.3% identity in 423 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00300 SRP54-type proteins GTP-binding domain signature. BELONGS TO THE SRP FAMILY OF GTP-BINDING PROTEINS. X2BLW3,P66843 No NC_002945.3 Mycobrowser_v2 CDS 3190817 3194434 . - 0 Mb2946c smc PROBABLE CHROMOSOME PARTITION PROTEIN SMC Mb2946c, smc, len: 1205 aa. Equivalent to Rv2922c,len: 1205 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1205 aa overlap). Probable smc,chromosome partition protein (ala-, arg-, leu-, glu-rich protein, possibly coiled-coil protein) (see * below),equivalent (but longer 84 aa) to Q9CBT5|SMC|ML1629|MLCB250.01 POSSIBLE CELL DIVISION PROTEIN from Mycobacterium leprae (1203 aa), FASTA scores: opt: 5957, E(): 0, (79.15% identity in 1205 aa overlap). Also highly similar to other chromosome segregation proteins e.g. Q9ZBQ2|SC7A1.21 PUTATIVE CHROMOSOME ASSOCIATED PROTEIN from Streptomyces coelicolor (1186 aa),FASTA scores: opt: 2633, E(): 4.1e-120, (53.03% identity in 1205 aa overlap); P51834|SMC_BACSU CHROMOSOME PARTITION PROTEIN from Bacillus subtilis (1186 aa), FASTA scores: opt: 1009, E(): 2.1e-41, (30.75% identity in 1205 aa overlap); Q9CHC9|SMC CHROMOSOME SEGREGATION PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (924 aa), FASTA scores: opt: 996, E(): 7.5e-41, (29.75% identity in 874 aa overlap); etc. Equivalent to AAK47317 from Mycobacterium tuberculosis strain CDC1551 (1205 aa) but longer 84 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SMC FAMILY. N-terminus shortened since first submission. [*Note: Cobbe N., Heck M.M.S.- Phylogenetic analysis of SMC proteins (OCT-2001)]. Q7TXM2 No NC_002945.3 Mycobrowser_v2 CDS 3194446 3194727 . - 0 Mb2947c acyP PROBABLE ACYLPHOSPHATASE ACYP (ACYLPHOSPHATE PHOSPHOHYDROLASE) Mb2947c, acyP, len: 93 aa. Equivalent to Rv2922A,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable acyP,acylphosphatase (acylphosphate phosphohydrolase) (EC 3.6.1.7), highly similar to others e.g. Q9ZBQ3|SC7A1.20 PUTATIVE ACYLPHOSPHATASE from Streptomyces coelicolor (93 aa), FASTA scores: opt: 345, E(): 9.5e-19, (58.9% identity in 90 aa overlap); P75877|ACYP_ECOLI|YCCX|B0968|Z1320|ECS1052 PUTATIVE ACYLPHOSPHATASE from Escherichia coli strains K12 and O157:H7 (92 aa), FASTA scores: opt: 220, E(): 2e-09,(44.95% identity in 89 aa overlap); Q9RVU3|DR0929 PUTATIVE ACYLPHOSPHATASE from Deinococcus radiodurans (87 aa),FASTA scores: opt: 193, E(): 2.1e-07, (44.3% identity in 79 aa overlap); etc. BELONGS TO THE ACYLPHOSPHATASE FAMILY. X2BM09,P69418 No NC_002945.3 Mycobrowser_v2 CDS 3194714 3195127 . - 0 Mb2948c conserved protein Mb2948c, -, len: 137 aa. Equivalent to Rv2923c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein, showing similarity with other hypothetical proteins e.g. P24246|YHFA_ECOLI|B3356|Z4717|ECS4207 from Escherichia coli strains K12 and O157:H7 (134 aa), FASTA scores: opt: 110, E(): 1.9, (25.9% identity in 135 aa overlap); etc. X2BMH5,P65056 No conserved hypotheticals Rv2923c NC_002945.3 Mycobrowser_v2 CDS 3195229 3196098 . - 0 Mb2949c fpg PROBABLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE FPG (FAPY-DNA GLYCOSYLASE) Mb2949c, fpg, len: 289 aa. Equivalent to Rv2924c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable fpg (alternate gene name: mutM), formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), equivalent to O69470|FPG_MYCLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium leprae (282 aa), FASTA scores: opt: 1563, E(): 1.3e-96,(80.6% identity in 289 aa overlap). Also highly similar to other formamidopyrimidine-DNA glycosylases e.g. Q9ZBQ6|FPG_STRCO from Streptomyces coelicolor (286 aa),FASTA scores: opt: 1047, E(): 2.9e-62, (57.55% identity in 292 aa overlap); P95744|FPG_SYNEN from Synechococcus elongatus naegeli (284 aa), FASTA scores: opt: 569, E(): 1.9e-30, (37.95% identity in 290 aa overlap); P05523|FPG_ECOLI|MUTM|FPG|B3635 from Escherichia coli strain K12 (269 aa), FASTA scores: opt: 424, E(): 8.2e-21,(33.9% identity in 289 aa overlap); etc. BELONGS TO THE FPG FAMILY. COFACTOR: BINDS 1 ZINC ION. X2BMT5,P64151 No NC_002945.3 Mycobrowser_v2 CDS 3197121 3197744 . - 0 Mb2951c conserved protein Mb2951c, -, len: 207 aa. Equivalent to Rv2926c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, equivalent to O69468|ML1660|MLCB1243.14 HYPOTHETICAL 23.5 KDA PROTEIN from Mycobacterium leprae (217 aa), FASTA scores: opt: 866, E(): 1.4e-48, (67.2% identity in 192 aa overlap). Also similar in part to other hypothetical proteins e.g. Q9WXZ8 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (182 aa), FASTA scores: opt: 254, E(): 3.4e-09,(31.45% identity in 143 aa overlap); Q9ZBQ9|SC7A1.14 HYPOTHETICAL 23.5 KDA PROTEIN from Streptomyces coelicolor (217 aa), FASTA scores: opt: 244, E(): 1.7e-08, (45.5% identity in 189 aa overlap); O65982 HYPOTHETICAL 26.2 KDA PROTEIN from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (228 aa),FASTA scores: opt: 220, E(): 6.1e-07, (32.45% identity in 148 aa overlap); etc. Equivalent to AAK47323 from Mycobacterium tuberculosis strain CDC1551 (195 aa) but longer 12 aa. X2BM68 No conserved hypotheticals Rv2926c NC_002945.3 Mycobrowser_v2 CDS 3197795 3198532 . - 0 Mb2952c CONSERVED HYPOTHETICAL PROTEIN Mb2952c, -, len: 245 aa. Equivalent to Rv2927c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Conserved hypothetical protein, equivalent to Q9CBS6|ML1661|MLCB1243.13 (alias O69467) HYPOTHETICAL PROTEIN from Mycobacterium leprae (247 aa), FASTA scores: opt: 1440, E(): 4.9e-76, (90.6% identity in 245 aa overlap). Also similar to many hypothetical proteins from other organisms e.g. Q9ZBR0|SC7A1.13 HYPOTHETICAL 41.0 KDA PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 266, E(): 3.4e-08, (29.9% identity in 234 aa overlap); etc. Also some similarity with P46815|AG84_MYCLE|ML0922 ANTIGEN 84 from Mycobacterium leprae (266 aa), FASTA scores: opt: 193, E(): 0.00043,(28.7% identity in 136 aa overlap) (see citation below); and P46816|AG84_MYCTU|WAG31|Rv2145c|MT2204|MTCY270.23 ANTIGEN 84 from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 178, E(): 0.0031, (34.35% identity in 131 aa overlap) (see citation below). Contains potential coiled-coil region. X2BM16 No conserved hypotheticals Rv2927c NC_002945.3 Mycobrowser_v2 CDS 3198771 3199556 . + 0 Mb2953 tesA PROBABLE THIOESTERASE TESA Mb2953, tesA, len: 261 aa. Equivalent to Rv2928,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable tesA,thioesterase (EC 3.1.2.-), equivalent to Q9Z5K4|ML2359|MLCB12.04c PUTATIVE THIOESTERASE from Mycobacterium leprae (261 aa), FASTA scores: opt: 1326,E(): 3.7e-80, (73.2% identity in 261 aa overlap). Also similar to others e.g. Q9ZGI1 THIOESTERASE II PIKAV from Streptomyces venezuelae (281 aa), FASTA scores: opt: 535,E(): 6.6e-28, (38.05% identity in 234 aa overlap); Q9L4W2|NYSE thioesterase involved in synthesis of the polyene antifungal antibiotic nystatin from Streptomyces noursei (see citation below) (251 aa), FASTA scores: opt: 523, E(): 3.8e-27, (34.53% identity in 223 aa overlap); Q54145 THIOESTERASE from Streptomyces fradiae (253 aa),FASTA scores: opt: 495, E(): 2.7e-25, (37.85% identity in 230 aa overlap); etc. X2BMI2,P63461 No lipid metabolism Rv2928 NC_002945.3 Mycobrowser_v2 CDS 3200270 3202021 . + 0 Mb2955 fadD26 fatty-acid-amp ligase fadd26 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb2955, fadD26, len: 583 aa. Equivalent to Rv2930,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 583 aa overlap). fadD26, fatty-acid-CoA synthetase (EC 6.2.1.-) (see first and third citations below), equivalent to Q9Z5K5|FADD26|ML2358|MLCB12.03c PROBABLE ACYL-CoA SYNTHASE from Mycobacterium leprae (583 aa), FASTA scores: opt: 3026, E(): 9.2e-180, (76.85% identity in 583 aa overlap). Also highly similar to many e.g. Q9CD84|ML0132 PUTATIVE ACYL-CoA SYNTHETASE from Mycobacterium leprae (680 aa), FASTA scores: opt: 2324,E(): 3.2e-136, (61.35% identity in 572 aa overlap); P71495 ACYL-CoA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2304, E(): 5e-135, (59.85% identity in 583 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50586|FD25_MYCTU|RV1521|MTCY19G5.07 PUTATIVE FATTY-ACID--CoA LIGASE (583 aa), FASTA scores: opt: 2188,E(): 7.6e-128, (57.55% identity in 584 aa overlap); etc. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. N-terminus shortened since first submission. Note that Rv2930|fadD26 belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). X2BLX3,Q7TXM1 No NC_002945.3 Mycobrowser_v2 CDS 3202018 3207648 . + 0 Mb2956 ppsA PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Mb2956, ppsA, len: 1876 aa. Equivalent to Rv2931,len: 1876 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 1876 aa overlap). ppsA, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9Z5K6|ML2357|MLCB12.02c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1871 aa), FASTA scores: opt: 7566,E(): 0, (76.1% identity in 1888 aa overlap); Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1540 aa), FASTA scores: opt: 4026,E(): 9.8e-212, (45.7% identity in 1811 aa overlap); Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE SYNTHASE (1446 aa), FASTA scores: opt: 4026, E(): 9.4e-212, (70.6% identity in 885 aa overlap). Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 2592, E(): 5.2e-133, (32.55% identity in 2245 aa overlap); P22367|MSAS_PENPA 6-methylsalicylic acid synthase from Penicillium patulum (Penicillium griseofulvum) (1774 aa), FASTA scores: opt: 2391, E(): 0, (34.2% identity in 1815 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1538 aa),FASTA scores: opt: 4227, E(): 0, (46.8% identity in 1810 aa overlap) (gap in middle); etc. Contains PS00606 Beta-ketoacyl synthases active site, and PS00012 Phosphopantetheine attachment site. Note that Rv2931|ppsA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). X2BM73,Q7TXM0 No NC_002945.3 Mycobrowser_v2 CDS 3212258 3218824 . + 0 Mb2958 ppsC PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Mb2958, ppsC, len: 2188 aa. Equivalent to Rv2933,len: 2188 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2188 aa overlap). ppsC, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q49933|PKSD|ML2355|L518_F1_3 PUTATIVE POLYKETIDE SYNTHASE (2201 aa), FASTA scores: opt: 6973, E(): 0, (82.32% identity in 2217 aa overlap); Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE (2118 aa), FASTA scores: opt: 4015, E(): 2.9e-208, (36.6% identity in 2184 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7 POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 3909, E(): 3.6e-202, (40.15% identity in 2220 aa overlap); Q9KIZ7|EPOD EPOD PROTEIN from Polyangium cellulosum (7257 aa), FASTA scores: opt: 3886, E(): 6.2e-201, (40.05% identity in 2220 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. P96291|Rv2940c (2111 aa), FASTA scores: opt: 4204, E(): 0,(39.1% identity in 2176 aa overlap); Q10977|PPSA_MYCTU|RV2931 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FASTA scores: opt: 3793,E(): 2.4e-196, (46.65% identity in 1612 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, and PS00012 Phosphopantetheine attachment site. Note that Rv2933|ppsC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). X2BMJ1,Q7TXL8 No NC_002945.3 Mycobrowser_v2 CDS 3224310 3228776 . + 0 Mb2960 ppsE PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Mb2960, ppsE, len: 1488 aa. Equivalent to Rv2935,len: 1488 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1488 aa overlap). ppsE, type-I polyketide synthase (see citations below), equivalent to Q49934|PKSF|ML2353|L518_F1_8 PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1489 aa), FASTA scores: opt: 8156, E(): 0, (82.05% identity in 1493 aa overlap). Also similar to polyketide synthases from other bacteria e.g. Q9RAH3|NOSB NOSB PROTEIN from Nostoc sp. GSV224 (1244 aa),FASTA scores: opt: 2438, E(): 8.8e-137, (43.75% identity in 969 aa overlap); Q9KIZ8|EPOC EPOC PROTEIN from Polyangium cellulosum (1832 aa), FASTA scores: opt: 2272,E(): 8.6e-127, (39.95% identity in 1061 aa overlap); O54155|SC3F7.12 POLYKETIDE SYNTHASE from Streptomyces coelicolor (2297 aa), FASTA scores: opt: 1522, E(): 3.6e-82, (36.35% identity in 1057 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2935|ppsE belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). X2BLX7,Q7TXL6 No NC_002945.3 Mycobrowser_v2 CDS 3228787 3229782 . + 0 Mb2961 drrA daunorubicin-dim-transport atp-binding protein abc transporter drra Mb2961, drrA, len: 331 aa. Equivalent to Rv2936,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 331 aa overlap). Probable drrA,daunorubicin-DIM-transport resistance ATP-binding protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q49938|DRRA|ML2352|L518_F2_43|DRRA PROBABLE DAUNORUBICIN RESISTANCE ATP-BINDING PROTEIN from Mycobacterium leprae (331 aa), FASTA scores: opt: 1842, E(): 4.2e-103, (85.2% identity in 331 aa overlap). Also highly similar to others e.g. Q9XCF7 DRRA from Mycobacterium avium (315 aa), FASTA scores: opt: 1040, E(): 4.7e-55, (54.35% identity in 309 aa overlap); Q9X5J8 DAUNORUBICIN RESISTANCE PROTEIN A from Mycobacterium avium (315 aa), FASTA scores: opt: 1030,E(): 1.9e-54, (53.7% identity in 309 aa overlap); P32010|DRRA_STRPE DAUNORUBICIN RESISTANCE ATP-BINDING PROTEIN from Streptomyces peucetius (330 aa), FASTA scores: opt: 852, E(): 9e-44, (47.15% identity in 318 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that Rv2936|drrA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). Q7TXL5 No cell wall and cell processes Rv2936 NC_002945.3 Mycobrowser_v2 CDS 3229779 3230648 . + 0 Mb2962 drrB daunorubicin-dim-transport integral membrane protein abc transporter drrb Mb2962, drrB, len: 289 aa. Equivalent to Rv2937,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable drrB,daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q49935|DRRB|ML2351|L518_F1_9 DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (288 aa), FASTA scores: opt: 1252,E(): 5.3e-72, (64.0% identity in 289 aa overlap). Also similar to others e.g. Q9XCF8 DRRB PROTEIN from Mycobacterium avium (246 aa), FASTA scores: opt: 423, E(): 1.5e-19, (30.85% identity in 243 aa overlap); Q9S6H4 DAUNORUBICIN RESISTANCE PROTEIN B from Mycobacterium avium (246 aa), FASTA scores: opt: 420, E(): 2.3e-19, (30.85% identity in 243 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces peucetius (283 aa), FASTA scores: opt: 242,E(): 4.7e-08, (27.85% identity in 219 aa overlap); etc. Note that Rv293|drrB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). Q7TXL4 No cell wall and cell processes Rv2937 NC_002945.3 Mycobrowser_v2 CDS 3230645 3231475 . + 0 Mb2963 drrC PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC Mb2963, drrC, len: 276 aa. Equivalent to Rv2938,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Probable drrC,daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q9CB71|ML2350 PROBABLE ANTIBIOTIC RESISTANCE MEMBRANE PROTEIN from Mycobacterium leprae (276 aa), FASTA scores: opt: 1434, E(): 1.2e-81, (79.0% identity in 276 aa overlap); and Q49941|DRRC|L518_F3_76 PUTATIVE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (244 aa), FASTA scores: opt: 1194, E(): 8.3e-67, (76.85% identity in 242 aa overlap). Also similar to others e.g. Q9XCF9 DRRC PROTEIN from Mycobacterium avium (263 aa), FASTA scores: opt: 538, E(): 3.7e-26, (32.65% identity in 251 aa overlap); Q9S6H3 DAUNORUBICIN RESISTANCE PROTEIN C from Mycobacterium avium (263 aa), FASTA scores: opt: 533, E(): 7.6e-26, (32.25% identity in 251 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces peucetius (283 aa), FASTA scores: opt: 276,E(): 6.6e-10, (21.07% identity in 261 aa overlap); etc. Note that Rv2938|drrC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). Q7TXL3 No cell wall and cell processes Rv2938 NC_002945.3 Mycobrowser_v2 CDS 3231522 3232790 . + 0 Mb2964 papA5 POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5 Mb2964, papA5, len: 422 aa. Equivalent to Rv2939,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Possible papA5,conserved polyketide synthase (PKS) associated protein (see first citation below), equivalent to Q49939 HYPOTHETICAL 45.6 KDA PROTEIN from Mycobacterium leprae (423 aa), FASTA scores: opt: 2398, E(): 4.5e-144, (84.05% identity in 426 aa overlap); and Q02279|YMA3_MYCBO HYPOTHETICAL 38.1 KDA PROTEIN from Mycobacterium bovis (354 aa), FASTA scores: opt: 2193, E(): 3.6e-131, (97.4% identity in 343 aa overlap). And C-terminus highly similar to to Q9S381 HYPOTHETICAL 5.0 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (44 aa), FASTA scores: opt: 275, E(): 1.4e-10, (88.65% identity in 44 aa overlap). Also similar in part to various synthetases e.g. Q9AE01|RIF20 RIF20 PROTEIN from Amycolatopsis mediterranei (Nocardia mediterranei) (403 aa), FASTA scores: opt: 282, E(): 2.7e-10, (30.3% identity in 393 aa overlap); middle part of Q00869|ESYN1 ENNIATIN SYNTHETASE (FRAGMENT) (N-methyl peptide synthetase) from Fusarium equiseti (3131 aa),FASTA scores: opt: 180, E(): 0.0036, (26.85% identity in 242 aa overlap); N-terminus of Q9FB18 PEPTIDE SYNTHETASE NRPS2-1 from Streptomyces verticillus (2626 aa), FASTA scores: opt: 159, E(): 0.068, (23.65% identity in 351 aa overlap); etc. Note that Rv2939|papA5 belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). X2BMV2,Q02279 No NC_002945.3 Mycobrowser_v2 CDS 3232953 3239288 . - 0 Mb2965c mas PROBABLE MULTIFUNCTIONAL MYCOCEROSIC ACID SYNTHASE MEMBRANE-ASSOCIATED MAS Mb2965c, mas, len: 2111 aa. Equivalent to Rv2940c,len: 2111 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2111 aa overlap). Probable mas,mycocerosic acid synthase membrane associated,multifunctional enzyme (see citations below), almost identical to Q02251|MCAS_MYCBO|MAS MYCOCEROSIC ACID SYNTHASE from Mycobacterium bovis (2110 aa), FASTA scores: opt: 13226, E(): 0, (95.8% identity in 2115 aa overlap) (see first citation below); and equivalent to Q9CD78|MAS|ML0139 PUTATIVE MYCOCEROSIC SYNTHASE from Mycobacterium leprae (2116 aa), FASTA scores: opt: 12142,E(): 0, (87.95% identity in 2119 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE from Mycobacterium leprae (2118 aa), FASTA scores: opt: 8421, E(): 0, (60.8% identity in 2127 aa overlap). Also similar to other synthases e.g. C-terminus of Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 4332, E(): 0,(40.85% identity in 2149 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 POLYKETIDE SYNTHASE (2108 aa), FASTA scores: opt: 5059, E(): 0,(65.9% identity in 2121 aa overlap); etc. Contains several domains, organized in the following order: beta-ketoacyl synthase (PS00606), acyl transferase, dehydratase-enoyl reductase, beta-ketoreductase, acyl carrier protein. Contains PS00012 Phosphopantetheine attachment site. X2BLY1,Q02251 No NC_002945.3 Mycobrowser_v2 CDS 3415663 3417354 . + 0 Mb3118 conserved protein Mb3118, -, len: 563 aa. Equivalent to Rv3091, len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 563 aa overlap). Hypothetical protein,similar in part to O60859 NEUROPATHY TARGET ESTERASE from Homo sapiens (Human) (1327 aa), FASTA scores: opt: 177,E(): 0.0062, (30.65% identity in 173 aa overlap); and Q9I385|PA1640 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (345 aa), FASTA scores: opt: 152, E(): 0.069,(27.8% identity in 180 aa overlap). Q7TX99 No conserved hypotheticals Rv3091 NC_002945.3 Mycobrowser_v2 CDS 3254525 3256642 . - 0 Mb2972c fadD22 p-hydroxybenzoyl-amp ligase fadd22 Mb2972c, fadD22, len: 705 aa. Equivalent to Rv2948c, len: 705 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 705 aa overlap). Probable fadD22, fatty-acid-CoA synthetase (EC 6.2.1.-). Highly similar to many e.g. Q9CD82|ML0134 putative acyl-CoA synthetase from Mycobacterium leprae (707 aa),fasta scores: opt: 3554, E(): 6.4e-209, (75.9% identity in 705 aa overlap). Almost identical to G560509|Q50468 PKS002A protein from Mycobacterium tuberculosis (705 aa),fasta scores: opt: 4647, E(): 0, (99.7% identity in 705 aa overlap). X2BM70,Q7TXK7 No lipid metabolism Rv2948c NC_002945.3 Mycobrowser_v2 CDS 3239908 3241650 . + 0 Mb2966 fadD28 fatty-acid-amp ligase fadd28 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb2966, fadD28, len: 580 aa. Equivalent to Rv2941,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 580 aa overlap). fadD28 (alternate gene name: acoas), fatty-acid-CoA synthetase (EC 6.2.1.-) (see citations below), almost identical to P71495 ACYL-COA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 3828, E(): 0, (99.15% identity in 580 aa overlap); and equivalent to Q9CD79|FADD28|ML0138 ACYL-COA SYNTHETASE from Mycobacterium leprae (579 aa), FASTA scores: opt: 3183, E(): 8.8e-186, (81.9% identity in 580 aa overlap). And also highly similar to others Mycobacteria proteins e.g. O07797|FADD23|Rv3826|MTCY409.04c PUTATIVE FATTY-ACID-COA SYNTHETASE from Mycobacterium tuberculosis (584 aa); etc. Contains PS00018 EF-hand calcium-binding domain. Note that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally coupled (proven experimentaly). X2BM82,Q02278 No NC_002945.3 Mycobrowser_v2 CDS 3241643 3244405 . + 0 Mb2967 mmpL7 CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL7 Mb2967, mmpL7, len: 920 aa. Equivalent to Rv2942,len: 920 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 920 aa overlap). mmpL7, conserved transmembrane transport protein (see citations below),member of RND superfamily, highly similar to Q9XB10 HYPOTHETICAL 99.5 KDA PROTEIN from Mycobacterium bovis BCG (945 aa), FASTA scores: opt: 488, E(): 4.9e-20, (29.5% identity in 918 aa overlap); and to others from Mycobacteria e.g. O53735|MML4_MYCTU from Mycobacterium tuberculosis (945 aa), FASTA scores: opt: 481, E(): 1.2e-19, (25.9% identity in 922 aa overlap); etc. Also similar to other membrane proteins e.g. O54101|MMLB_STRCO|SC10A5.10c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (847 aa), FASTA scores: opt: 256, E(): 7.2e-07, (25.15% identity in 545 aa overlap); etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, PS00079 Multicopper oxidases signature 1, and PS00044 Bacterial regulatory proteins, lysR family signature. BELONGS TO THE MMPL FAMILY. Note that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally coupled (proven experimentaly). X2BM63,P65371 No NC_002945.3 Mycobrowser_v2 CDS 3245037 3246278 . + 0 Mb2968 PROBABLE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1533 Mb2968, -, len: 413 aa. Equivalent to Rv2943, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable transposase for insertion sequence IS1533, similar to other transposases e.g. P15025|ISTA_ECOLI ista protein (insertion sequence IS21) from Escherichia coli (390 aa),FASTA scores: opt: 268, E(): 5.1e-11, (24.1% identity in 378 aa overlap). Contains potential helix-turn-helix motif at aa 19-40 (Score 1611, +4.67 SD). Q7TXL0 No insertion seqs and phages Rv2943 NC_002945.3 Mycobrowser_v2 CDS 3246278 3246808 . + 0 Mb2969 POSSIBLE TRANSPOSASE Mb2969, -, len: 176 aa. Equivalent to Rv2943A, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Possible transposase,similar to many e.g. AJ238712|MBO238712_2 PUTATIVE TRANSPOSASE (IS21-l) from Mycobacterium bovis BCG (266 aa), FASTA scores: opt: 762, E(): 0, (100.0% identity in 118 aa overlap). Possible frameshift after codon 118 i.e. near position 3290056, to fuse with Rv2944. Q7TXK9 No insertion seqs and phages Rv2943A NC_002945.3 Mycobrowser_v2 CDS 3247197 3247898 . - 0 Mb2970c lppX PROBABLE CONSERVED LIPOPROTEIN LPPX Mb2970c, lppX, len: 233 aa. Equivalent to Rv2945c,len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Probable lppX,conserved lipoprotein, equivalent to Q9CD80 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (233 aa), FASTA scores: opt: 1165, E(): 2.1e-65, (76.4% identity in 233 aa overlap); and similar to Q9CCP6|ML0557 from Mycobacterium leprae (238 aa), FASTA scores: opt: 338, E(): 7.4e-14,(30.75% identity in 231 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. P71679|LPRG_MYCTU LIPOPROTEIN (236 aa), FASTA scores: opt: 342, E(): 4.1e-14, (32.05% identity in 231 aa overlap); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and has in its N-terminal a signal peptide. BELONGS TO THE LPPX/LPRAFG FAMILY OF LIPOPROTEINS. X2BLZ5,P65307 No NC_002945.3 Mycobrowser_v2 CDS 3248190 3254528 . - 0 Mb2971c pks1 probable polyketide synthase pks15 Mb2971c, pks1, len: 2112 aa. Equivalent to Rv2947c and Rv2946c, len: 496 aa and 1616 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 488 aa overlap and 99.9% identity in 1616 aa overlap). Rv2947c: Probable pks15, polyketide synthase. Almost identical to G560508|Q50469 PKS002B protein from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 3270, E(): 0,(99.6% identity in 496 a a overlap). Similar to Mycobacterium tuberculosis proteins MTCY338.20|RV2931|PPSA_MYCTU ppsA phenolpthiocerol synthesis (1876 aa) (49.9% identity in 465 aa overlap); MTCY24G1.09|RV2940C|P96291 Putative mas, mycocerosic acid synthase (2111 aa) (50.2% identity in 454 aa overlap); and MTCY22H8.03|RV2382C|P71718 hypothetical protein (444 aa) (47.6% identity in 437 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site. Rv2946c: Probable pks1, polyketide synthase, similar to many e.g. ML035|AL583917|Q9CD81 putative polyketide synthase from Mycobacterium leprae (2103 aa), Fasta scores: opt: 8761,E(): 0, (82.6% identity in 1620 aa overlap); etc. Almost identical in part to G560507|Q50470 PKS002C protein from Mycobacterium tuberculosis (fragment) (950 aa), Fasta scores: opt: 5685, E(): 0, (95.3% identity in 927 aa overlap). Also similar to Mycobacterium tuberculosis polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6% identity in 1632 aa); pks12|Rv2048c|O53490 (4151 aa) (58.0% identity in 1606 aa); pks8|rv1662|O65933 (1602 aa) (59.7% identity in 1144 aa). Contains a PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-g) results in a single product that is more similar to pks1. X2BMA9,Q7TXK8 No lipid metabolism Rv2947c NC_002945.3 Mycobrowser_v2 CDS 3257284 3259143 . - 0 Mb2974c fadD29 fatty-acid-amp ligase fadd29 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb2974c, fadD29, len: 619 aa. Equivalent to Rv2950c, len: 619 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 619 aa overlap). Probable fadD29, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to various mycobacterial enzymes believed to be involved in polyketide or fatty acid synthesis. Equivalent (but shorter 61 aa) to Q9CD84 from Mycobacterium leprae (680 aa), FASTA scores: opt: 3280, E(): 2.2e-192, (80.15% identity in 620 aa overlap); and highly similar to others from Mycobacterium leprae e.g. Q9Z5K5 PROBABLE ACYL-COA SYNTHASE (583 aa), FASTA scores: opt: 2358, E(): 3.4e-136,(62.35% identity in 579 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. Q10976|FD26_MYCTU PUTATIVE FATTY-ACID--CoA LIGASE (583 aa), FASTA scores: opt: 2416, E(): 1e-139, (63.15% identity in 581 aa overlap) (N-terminus shorter); etc. Equivalent to AAK47349 from Mycobacterium tuberculosis strain CDC1551 (582 aa) but longer 37 aa. X2BMY4,Q7TXK5 No lipid metabolism Rv2950c NC_002945.3 Mycobrowser_v2 CDS 3259791 3260936 . - 0 Mb2975c POSSIBLE OXIDOREDUCTASE Mb2975c, -, len: 381 aa. Equivalent to Rv2951c,len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 381 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to Q9CD85 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (382 aa), FASTA scores: opt: 2225, E(): 7.6e-134, (84.8% identity in 382 aa overlap); and similar to O30260 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (363 aa), FASTA scores: opt: 652, E(): 6.1e-34, (32.55% identity in 344 aa overlap). Also similar to various oxidoreductases e.g. O29071|AF1196 N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Archaeoglobus fulgidus (348 aa), FASTA scores: opt: 381, E(): 9.7e-17, (27.7% identity in 354 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 372, E(): 3.5e-16, (30.85% identity in 295 aa overlap); Q9UXP0 PUTATIVE F420-DEPENDENT N5,N10-METHYLENE-TETRAHYDROMETHANOPTERIN REDUCTASE from Methanolobus tindarius (326 aa), FASTA scores: opt: 343,E(): 2.4e-14, (27.4% identity in 314 aa overlap); etc. X2BM02,Q7TXK4 No intermediary metabolism and respiration Rv2951c NC_002945.3 Mycobrowser_v2 CDS 3328430 3329086 . + 0 Mb3038 conserved protein Mb3038, -, len: 218 aa. Equivalent to Rv3013, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Conserved hypothetical protein, equivalent to O33103|MLCB637_11c HYPOTHETICAL 24.4 KDA PROTEIN from Mycobacterium leprae (230 aa), FASTA scores: opt: 1188, E(): 2.6e-67, (83.95% identity in 218 aa overlap). Equivalent to AAK47422 from Mycobacterium tuberculosis strain CDC1551 (240 aa) but shorter 22 aa. Q7TXG1 No conserved hypotheticals Rv3013 NC_002945.3 Mycobrowser_v2 CDS 3261129 3261941 . + 0 Mb2976 POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb2976, -, len: 270 aa. Equivalent to Rv2952, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Probable methyltransferase (EC 2.1.1.-), equivalent to Q9CD86|ML0130 HYPOTHETICAL PROTEIN from Mycobacterium leprae (270 aa), FASTA scores: opt: 1584, E(): 6.1e-99,(83.7% identity in 270 aa overlap). Also highly similar to Q9RMN9|MTF2 PUTATIVE METHYLTRANSFERASE from Mycobacterium smegmatis (274 aa), FASTA scores: opt: 902, E(): 3.8e-53,(56.35% identity in 252 aa overlap). Also similar to other methyltransferases e.g. Q9ADL4|SORM O-METHYLTRANSFERASE from Polyangium cellulosum (346 aa), FASTA scores: opt: 390, E(): 1.1e-18, (36.25% identity in 251 aa overlap); Q54303|RAPM METHYLTRANSFERASE from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 315, E(): 1.1e-13, (40.75% identity in 135 aa overlap); etc. Very similar to C-terminal part of Q50584|Rv1523|MTCY19G5.05c HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium tuberculosis (358 aa), FASTA score: opt: 965, E(): 2.7e-57, (60.3% identity in 247 aa overlap). X2BMB7,Q7TXK3 No intermediary metabolism and respiration Rv2952 NC_002945.3 Mycobrowser_v2 CDS 3423757 3424209 . - 0 Mb3125c HYPOTHETICAL PROTEIN Mb3125c, -, len: 150 aa. Equivalent to Rv3098c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Hypothetical unknown protein (shorter version of MTCY164.09c). Q7TX93 No conserved hypotheticals Rv3098c NC_002945.3 Mycobrowser_v2 CDS 3261967 3263223 . + 0 Mb2977 enoyl reductase Mb2977, -, len: 418 aa. Equivalent to Rv2953, len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 418 aa overlap). Conserved hypothetical protein, equivalent to Q9CD87|ML0129 HYPOTHETICAL PROTEIN from Mycobacterium leprae (418 aa),FASTA scores: opt: 2357, E(): 2.7e-143, (86.6% identity in 418 aa overlap). Also highly similar to Q9X7N5|SC5F2A.12c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (396 aa), FASTA scores: opt: 491, E(): 7e-24,(38.35% identity in 417 aa overlap); and similar to other hypothetical proteins e.g. Q9VG81 CG5167 PROTEIN from Drosophila melanogaster (Fruit fly) (431 aa), FASTA scores: opt: 393, E(): 1.4e-17, (26.55% identity in 433 aa overlap); Q9GZE9|F22F7.1 HYPOTHETICAL PROTEIN from Caenorhabditis elegans (426 aa), FASTA scores: opt: 338,E(): 4.6e-14, (27.05% identity in 425 aa overlap); P73855|SLL1601 HYPOTHETICAL 44.8 KDA PROTEIN from Synechocystis sp. (strain PCC 6803) (414 aa), FASTA scores: opt: 565, E(): 1.3e-28, (35.7% identity in 409 aa overlap); etc. Also highly similar to other proteins from Mycobacterium tuberculosis e.g. RV2449C|O53176|MTV008.05C HYPOTHETICAL 44.4 KDA PROTEIN (419 aa), FASTA scores: opt: 1835, E(): 7e-110, (67.55% identity in 419 aa overlap); etc. X2BM75,Q7TXK2 No lipid metabolism Rv2953 NC_002945.3 Mycobrowser_v2 CDS 3263354 3264079 . - 0 Mb2978c HYPOTHETICAL PROTEIN Mb2978c, -, len: 241 aa. Equivalent to Rv2954c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Hypothetical unknown protein. Equivalent to AAK47354 from Mycobacterium tuberculosis strain CDC1551 (199 aa) but longer 42 aa. Q7TXK1 No conserved hypotheticals Rv2954c NC_002945.3 Mycobrowser_v2 CDS 3696732 3696989 . - 0 Mb3378c conserved transmembrane protein Mb3378c, -, len: 85 aa. Equivalent to Rv3346c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, highly similar to mycobacterium hypothetical proteins O50384|Rv3355c|MTV004.12c from strain H37Rv (97 aa), FASTA scores: opt: 413, E(): 4.6e-23, (85.55% identity in 97 aa overlap); O32878|MLCB1779.16c|ML0675 from Mycobacterium leprae (91 aa), FASTA scores: opt: 349,E(): 1.7e-18, (67.35% identity in 95 aa overlap). Q7TWN8 No cell wall and cell processes Rv3346c NC_002945.3 Mycobrowser_v2 CDS 3264268 3265233 . - 0 Mb2979c conserved protein Mb2979c, -, len: 321 aa. Equivalent to Rv2955c,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 321 aa overlap). Conserved hypothetical protein, similar to others e.g. Q98NV5|MLL9724 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (284 aa), FASTA scores: opt: 231, E(): 6.5e-08,(34.6% identity in 182 aa overlap); Q9AGG2|NLPE1 NLPE1 from Rhizobium etli (249 aa), FASTA scores: opt: 212, E(): 1.1e-06, (27.85% identity in 255 aa overlap); Q9KXY2 HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces coelicolor(291 aa), FASTA scores: opt: 211, E(): 1.4e-06,(30.9% identity in 249 aa overlap); etc. Q7TXK0 No conserved hypotheticals Rv2955c NC_002945.3 Mycobrowser_v2 CDS 3265356 3266087 . + 0 Mb2980 conserved protein Mb2980, -, len: 243 aa. Equivalent to Rv2956, len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 243 aa overlap). Conserved hypothetical protein, highly similar to O86299|GSC GSC PROTEIN from Mycobacterium avium subsp. silvaticum Mycobacterium avium (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap); and O86294|GSC GSC PROTEIN from Mycobacterium paratuberculosis (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap). Also some similarity with other proteins from other organisms e.g. Q9L727 NODULATION PROTEIN NOEI from Rhizobium fredii (Sinorhizobium fredii) (241 aa), FASTA scores: opt: 205, E(): 3.5e-06, (27.25% identity in 198 aa overlap); Q9AGG1|LPEA LPEA PROTEIN from Rhizobium etli (286 aa), FASTA scores: opt: 201, E(): 7.2e-06, (28.85% identity in 208 aa overlap); P74191|SLL1173 HYPOTHETICAL 28.0 KDA PROTEIN Synechocystis sp. (strain PCC 6803) (244 aa), FASTA scores: opt: 274, E(): 1e-10, (30.65% identity in 225 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P71792|RV1513|MTCY277.35 HYPOTHETICAL 26.7 KDA PROTEIN (243 aa), FASTA scores: opt: 1105, E(): 1.7e-65, (70.05% identity in 237 aa overlap); etc. Q7TXJ9 No conserved hypotheticals Rv2956 NC_002945.3 Mycobrowser_v2 CDS 3266158 3266985 . + 0 Mb2981 POSSIBLE GLYCOSYL TRANSFERASE Mb2981, -, len: 275 aa. Equivalent to Rv2957, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Possible glycosyl transferase (EC 2.4.1.-); possibly secreted protein. Highly similar to O88109|GSD|GTFD GSD PROTEIN from Mycobacterium avium subsp. silvaticum, Mycobacterium paratuberculosis, and Mycobacterium avium (266 aa), FASTA scores: opt: 1010, E(): 2.5e-62, (68.8% identity in 221 aa overlap). Also some similarity with other proteins and especially glycosyl transferases e.g. Q9AEE4 HYPOTHETICAL 31.4 KDA PROTEIN from Leptospira interrogans (265 aa),FASTA scores: opt: 371, E(): 3.3e-18, (34.43% identity in 212 aa overlap); Q9EXY4 PUTATIVE GLYCOSYL TRANSFERASE from Escherichia coli (248 aa), FASTA scores: opt: 339, E(): 5e-16, (32.4% identity in 210 aa overlap); Q9RCC4 GLYCOSYLTRANSFERASE-LIKE PROTEIN from Yersinia pestis (247 aa), FASTA scores: opt: 333, E(): 1.3e-15, (31.8% identity in 217 aa overlap); Q9EXY1 PUTATIVE GLYCOSYL TRANSFERASE from Escherichia coli (248 aa), FASTA scores: opt: 328,E(): 2.9e-15, (31.9% identity in 210 aa overlap); etc. Equivalent to AAK47357 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 19 aa. X2BMC2,P0A5A0 No intermediary metabolism and respiration Rv2957 NC_002945.3 Mycobrowser_v2 CDS 3292647 3293192 . + 0 Mb3004 POSSIBLE CONSERVED SECRETED PROTEIN Mb3004, -, len: 181 aa. Equivalent to Rv2980, len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Possible conserved secreted protein, equivalent to Q9CBS1 POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (191 aa), FASTA scores: opt: 794, E(): 2.3e-40, (67.25% identity in 177 aa overlap). Also some weak similarity with other hypothetical proteins or secreted proteins e.g. C-terminus of Q98F98|MLL3872 MLL3872 PROTEIN from Rhizobium loti (Mesorhizobium loti) (575 aa), FASTA scores: opt: 148,E(): 0.16, (28.35% identity in 194 aa overlap); Q9L0W9|SCH22A.13C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 114,E(): 7.5, (40.0% identity in 80 aa overlap); etc. Equivalent to AAK47385 from Mycobacterium tuberculosis strain CDC1551 (214 aa) but shorter 33 aa. Has hydrophobic stretch near N-terminus. Q7TXI0 No cell wall and cell processes Rv2980 NC_002945.3 Mycobrowser_v2 CDS 3267589 3268689 . - 0 Mb2982c possible glycosyl transferase Mb2982c, -, len: 366 aa. Similar to 5' end of Rv2958c, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv, (83.3% identity in 371 aa overlap). Possible glycosyl transferase (EC 2.4.1.-), highly similar to Q9CD88|ML0128 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (435 aa), FASTA scores: opt: 2116,E(): 5.8e-126, (75.05% identity in 417 aa overlap); and Q9CD91|ML0125 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2104,E(): 3.3e-125, (74.65% identity in 418 aa overlap). Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3 PUTATIVE GLYCOSYLTRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 317, E(): 1.9e-12, (31.0% identity in 297 aa overlap); Q9S1V2 PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (407 aa), FASTA scores: opt: 264, E(): 4.1e-09, (27.2% identity in 342 aa overlap); P72650|CRTX|SLR1125 ZEAXANTHIN GLUCOSYL TRANSFERASE from Synechocystis sp. strain PCC 6803 (419 aa), FASTA scores: opt: 251, E(): 2.8e-08, (26.8% identity in 295 aa overlap); etc. Very similar to P95130|MTCY349.25 from Mycobacterium tuberculosis (449 aa), FASTA score: opt: 2215, E(): 3.3e-132, (77.25% identity in 422 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. X2BM79,Q7TXJ8 No NC_002945.3 Mycobrowser_v2 CDS 3268790 3269527 . - 0 Mb2983c POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb2983c, -, len: 245 aa. Equivalent to Rv2959c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Possible methyltransferase (EC 2.1.1.-), highly similar to Q9CD89|ML0127 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1183, E(): 3.9e-69, (76.1% identity in 226 aa overlap). Also some similarity with other methyltransferases and other proteins e.g. Q51079 PUTATIVE METHYL TRANSFERASE from Nocardia lactamdurans (236 aa),FASTA scores: opt: 156, E(): 0.0086, (23.25% identity in 159 aa overlap); Q98ID5 CEPHALOSPORIN HYDROXYLASE from Rhizobium loti (Mesorhizobium loti) (217 aa), FASTA scores: opt: 275, E(): 1.7e-10, (29.65% identity in 199 aa overlap); etc. And also similar to P72897 HYPOTHETICAL 27.8 KDA PROTEIN from Mycobacterium tuberculosis (249 aa),FASTA scores: opt: 292, E(): 1.5e-11, (31.25% identity in 208 aa overlap). X2BMP5,Q7TXJ7 No intermediary metabolism and respiration Rv2959c NC_002945.3 Mycobrowser_v2 CDS 3269642 3269890 . - 0 Mb2984c HYPOTHETICAL PROTEIN Mb2984c, -, len: 82 aa. Equivalent to Rv2960c, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 82 aa overlap). Hypothetical unknown protein, equivalent to AAK47362 from Mycobacterium tuberculosis strain CDC1551 (116 aa) but shorter 34 aa. Shortened version of MTCY349.28 avoiding overlap. Q7TXJ6 No conserved hypotheticals Rv2960c NC_002945.3 Mycobrowser_v2 CDS 3269972 3270361 . + 0 Mb2985 PROBABLE TRANSPOSASE Mb2985, -, len: 129 aa. Equivalent to Rv2961, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Probable transposase,highly similar to C-terminus of O50414|Rv3387|MTV004.45 PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (225 aa), FASTA scores: opt: 605, E(): 7.2e-34, (66.65% identity in 129 aa overlap); and similar to others e.g. CAC47401 PUTATIVE PARTIAL TRANSPOSASE FOR ISRM17 PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (174 aa),FASTA scores: opt: 183, E(): 2.6e-05, (30.25% identity in 129 aa overlap); etc. Q7TXJ5 No insertion seqs and phages Rv2961 NC_002945.3 Mycobrowser_v2 CDS 3270462 3271811 . - 0 Mb2986c POSSIBLE GLYCOSYL TRANSFERASE Mb2986c, -, len: 449 aa. Equivalent to Rv2962c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Possible glycosyl transferase (EC 2.4.1.-), highly similar or identical to Mycobacterium tuberculosis proteins G560522 U0002JA,G560521 U0002H, G560522 U0002JA, G560519 U0002KA. Equivalent (but longer 21 aa) to Q9CD91 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2229, E(): 1.3e-133, (77.45% identity in 426 aa overlap); and highly similar to Q9CD88 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (435 aa),FASTA scores: opt: 2129, E(): 2.7e-127, (74.35% identity in 425 aa overlap); and others from Mycobacterium leprae. Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3|DRA0329 PUTATIVE GLYCOSYL TRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 340, E(): 5.5e-14, (31.2% identity in 330 aa overlap); P72650 ZEAXANTHIN GLUCOSYL TRANSFERASE from Synechocystis sp. (strain PCC 6803) (419 aa), FASTA scores: opt: 244, E(): 6.6e-08, (26.2% identity in 294 aa overlap); etc. Also highly similar to P95134 HYPOTHETICAL 46.8 KDA PROTEIN from Mycobacterium tuberculosis (428 aa),FASTA scores: opt: 2215, E(): 9.6e-133, (77.25% identity in 422 aa overlap). X2BMC4,Q7TXJ4 No intermediary metabolism and respiration Rv2962c NC_002945.3 Mycobrowser_v2 CDS 3271925 3273145 . + 0 Mb2987 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb2987, -, len: 406 aa. Equivalent to Rv2963, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable integral membrane protein. Q7TXJ3 No cell wall and cell processes Rv2963 NC_002945.3 Mycobrowser_v2 CDS 3291851 3292435 . - 0 Mb3003c PROBABLE RESOLVASE Mb3003c, -, len: 194 aa. Equivalent to Rv2979c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(98.5% identity in 194 aa overlap). Probable resolvase for IS1538, with low level matches to transposon resolvases; highly similar from aa 101 to YX1C_MYCTU|Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 809, E(): 0, (69.1% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site, and possible helix-turn-helix motiv at aa 2-23. Q7TXI1 No insertion seqs and phages Rv2979c NC_002945.3 Mycobrowser_v2 CDS 3273218 3274150 . + 0 Mb2988 purU PROBABLE FORMYLTETRAHYDROFOLATE DEFORMYLASE PURU (FORMYL-FH(4) HYDROLASE) Mb2988, purU, len: 310 aa. Equivalent to Rv2964,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Probable purU,formyltetrahydrofolate deformylase (EC 3.5.1.10), highly similar to others e.g. Q9RWT1|DR0584 FORMYLTETRAHYDROFOLATE DEFORMYLASE from Deinococcus radiodurans (298 aa), FASTA scores: opt: 1005, E(): 4.9e-52, (52.25% identity in 297 aa overlap); Q9K7U4 FORMYLTETRAHYDROFOLATE DEFORMYLASE from Bacillus halodurans (289 aa), FASTA scores: opt: 982, E(): 1.1e-50,(51.8% identity in 280 aa overlap); Q55135|PURU_SYNY3|SLL0070 FORMYLTETRAHYDROFOLATE DEFORMYLASE from Synechocystis sp. strain PCC 6803 (284 aa), FASTA scores: opt: 839, E(): 2.9e-42, (48.2% identity in 280 aa overlap); etc. X2BMP9,P0A5T7 No intermediary metabolism and respiration Rv2964 NC_002945.3 Mycobrowser_v2 CDS 3275019 3275504 . - 0 Mb2989c kdtB PROBABLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE KDTB (PANTETHEINE-PHOSPHATE ADENYLYLTRANSFERASE) (PPAT) (DEPHOSPHO-COA PYROPHOSPHORYLASE) Mb2989c, kdtB, len: 161 aa. Equivalent to Rv2965c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Probable kdtB (alternate gene name: coaD), phosphopantetheine adenylyltransferase (EC 2.7.7.3), equivalent to O69466|COAD_MYCLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE from Mycobacterium leprae (160 aa), FASTA scores: opt: 881, E(): 2.5e-54, (84.1% identity in 157 aa overlap). Also highly similar to others e.g. Q9ZBR1|COAD_STRCO from Streptomyces coelicolor (159 aa), FASTA scores: opt: 575,E(): 5.8e-33, (54.1% identity in 159 aa overlap); Q9WZK0|COAD_THEMA from Thermotoga maritima (161 aa), FASTA scores: opt: 509, E(): 2.4e-28, (50.0% identity in 154 aa overlap); P23875|COAD_ECOLICOAD|KDTB|B3634|Z5058|ECS4509 from Escherichia coli strain O157:H7 and K12 (159 aa),FASTA scores: opt: 459, E(): 7.3e-25, (45.15% identity in 155 aa overlap); etc. BELONGS TO THE COAD FAMILY. X2BMZ6,P0A531 No NC_002945.3 Mycobrowser_v2 CDS 3275590 3276156 . - 0 Mb2990c POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb2990c, -, len: 188 aa. Equivalent to Rv2966c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Possible methyltransferase (EC 2.1.1.-), equivalent (but shorter 36 aa) to O69465|MLCB1243.09 HYPOTHETICAL 23.0 KDA PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 872, E(): 9.1e-50, (74.2% identity in 182 aa overlap). Also similar to others e.g. Q9ZBR2|SC7A1.11 PUTATIVE METHYLASE from Streptomyces coelicolor (195 aa), FASTA scores: opt: 510, E(): 3.7e-26, (47.5% identity in 179 aa overlap); Q9F842 HYPOTHETICAL METHYLTRANSFERASE (FRAGMENT) from Mycobacterium smegmatis (80 aa), FASTA scores: opt: 386, E(): 2.5e-18, (75.0% identity in 80 aa overlap); P10120|YHHF_ECOLI|YHHFZ|B3465 PUTATIVE METHYLASE from Escherichia colistrain K12 (198 aa), FASTA scores: opt: 319, E(): 1.1e-13, (35.5% identity in 183 aa overlap); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Q7TXJ2 No intermediary metabolism and respiration Rv2966c NC_002945.3 Mycobrowser_v2 CDS 3276352 3279735 . - 0 Mb2991c pca PROBABLE PYRUVATE CARBOXYLASE PCA (PYRUVIC CARBOXYLASE) Mb2991c, pca, len: 1127 aa. Equivalent to Rv2967c,len: 1127 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1127 aa overlap). Probable pca,pyruvate carboxylase (ala-rich protein) (EC 6.4.1.1),equivalent to Q9F843|PYC PYRUVATE CARBOXYLASE from Mycobacterium smegmatis (1127 aa), FASTA scores: opt: 6232, E(): 0, (83.3% identity in 1127 aa overlap). Also highly similar to others e.g. Q9RK64|SCF11.26c PYRUVATE CARBOXYLASE from Streptomyces coelicolor (1124 aa), FASTA scores: opt: 5526, E(): 0, (74.65% identity in 1125 aa overlap); O54587|PYC PYRUVATE CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (1140 aa), FASTA scores: opt: 4811, E(): 0, (64.5% identity in 1132 aa overlap); Q9DDT1 PYRUVATE CARBOXYLASE from Brachydanio rerio (Zebrafish) (1180 aa), FASTA scores: opt: 3133, E(): 1.1e-171, (47.8% identity in 1142 aa overlap); etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2, PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site, and PS00188 Biotin-requiring enzymes attachment site. Q7TXJ1 No NC_002945.3 Mycobrowser_v2 CDS 3351939 3353021 . + 0 Mb3061 conserved protein Mb3061, -, len: 360 aa. Equivalent to Rv3035, len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 360 aa overlap). Conserved hypothetical protein, equivalent to Q9CBR0|ML1720 HYPOTHETICAL PROTEIN from Mycobacterium leprae (364 aa),FASTA scores: opt: 1963, E(): 1.4e-108, (75.8% identity in 363 aa overlap). Q7TXE5 No conserved hypotheticals Rv3035 NC_002945.3 Mycobrowser_v2 CDS 3293365 3294477 . - 0 Mb3005c ddlA PROBABLE D-ALANINE--D-ALANINE LIGASE DDLA (D-ALANYLALANINE SYNTHETASE) (D-ALA-D-ALA LIGASE) Mb3005c, ddlA, len: 370 aa. Equivalent to Rv2981c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 373 aa overlap). Probable ddlA (alternate gene name: ddl), D-alanine--D-alanine ligase A (EC 6.3.2.4), equivalent to Q9CBS0|Q9CBS0 D-ALANINE-D-ALANINE LIGASE A from Mycobacterium leprae (384 aa), FASTA scores: opt: 2001, E(): 2.4e-115, (81.75% identity in 367 aa overlap); and Q9ZGN0|DDL_MYCSM D-ALANINE--D-ALANINE LIGASE from Mycobacterium smegmatis (373 aa), FASTA scores: opt: 1934, E(): 3.1e-111, (77.95% identity in 372 aa overlap). Also highly similar to others e.g. Q9ZBR9|DDL_STRCO from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1187, E(): 2.2e-65, (52.0% identity in 379 aa overlap); P15051|DDLA_SALTY from Salmonella typhimurium and Salmonella typhi (363 aa),FASTA scores: opt: 946, E(): 1.3e-50, (44.5% identity in 364 aa overlap); P23844|DDLA_ECOLI|DDLA|B0381|Z0477|ECS0431 from Escherichia coli strain O157:H7 and K12 (364 aa), FASTA scores: opt: 938, E(): 3.9e-50, (43.55% identity in 363 aa overlap); etc. Contains PS00843 D-alanine--D-alanine ligase signature 1. BELONGS TO THE D-ALANINE--D-ALANINE LIGASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (acgccggtc-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (370 aa versus 373 aa). X2BMD9,Q7TXH9 No NC_002945.3 Mycobrowser_v2 CDS 3279760 3280392 . - 0 Mb2992c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb2992c, -, len: 210 aa. Equivalent to Rv2968c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Probable conserved integral membrane protein, equivalent to O69464 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (214 aa), FASTA scores: opt: 1060, E(): 1.4e-58, (71.95% identity in 214 aa overlap). Also highly similar to others e.g. Q9F844 HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Mycobacterium smegmatis (187 aa), FASTA scores: opt: 883,E(): 1.2e-47, (62.8% identity in 190 aa overlap); Q9KXP3 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (240 aa), FASTA scores: opt: 503, E(): 4.6e-24,(38.0% identity in 192 aa overlap); etc. Q7TXJ0 No cell wall and cell processes Rv2968c NC_002945.3 Mycobrowser_v2 CDS 3280398 3281165 . - 0 Mb2993c POSSIBLE CONSERVED MEMBRANE OR SECRETED PROTEIN Mb2993c, -, len: 255 aa. Equivalent to Rv2969c,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Possible conserved membrane or exported protein, equivalent to Q9CBS4|ML1667 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1101, E(): 9.9e-68,(65.9% identity in 258 aa overlap); and highly similar to O69463 PUTATIVE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (258 aa), FASTA scores: opt: 1097, E(): 1.8e-67,(65.5% identity in 258 aa overlap). C-terminus also highly similar to Q9KK65|996A160 EXPORTED PROTEIN (FRAGMENT) from Mycobacterium avium (85 aa), FASTA scores: opt: 418, E(): 2e-21, (72.95% identity in 85 aa overlap). Also weakly similar to membrane or exported proteins e.g. Q9S2U7|SC4G6.04c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (275 aa), FASTA scores: opt: 312,E(): 7.6e-14, (28.25% identity in 230 aa overlap); Q9XAB6|SCC22.22C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (255 aa), FASTA scores: opt: 181,E(): 6.4e-05, (27.0% identity in 226 aa overlap); etc. Also some similarity with P72001|PKNE_MYCTU from Mycobacterium tuberculosis (566 aa), FASTA scores: opt: 264, E(): 2.3e-10, (30.5% identity in 177 aa overlap). Q7TXI9 No cell wall and cell processes Rv2969c NC_002945.3 Mycobrowser_v2 CDS 3281262 3282392 . - 0 Mb2994c lipN PROBABLE LIPASE/ESTERASE LIPN Mb2994c, lipN, len: 376 aa. Equivalent to Rv2970c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Probable lipN,lipase/esterase (EC 3.1.1.-), similar to others e.g. Q9AA37|CC0771 PUTATIVE ESTERASE from Caulobacter crescentus (380 aa), FASTA scores: opt: 822, E(): 8e-46,(42.15% identity in 318 aa overlap); Q9XDR4 ESTERASE HDE from petroleum-degrading bacterium HD-1 (317 aa), FASTA scores: opt: 738, E(): 2e-40, (48.85% identity in 262 aa overlap); O52270 LIPASE from Pseudomonas sp. (strain B11-1) (308 aa), FASTA scores: opt: 683, E(): 7.3e-37,(41.3% identity in 288 aa overlap); etc. Also similar to P71668 HYPOTHETICAL 34.1 KDA PROTEIN from Mycobacterium tuberculosis (320 aa), FASTA scores: opt: 715, E(): 6.3e-39, (42.3% identity in 298 aa overlap). Equivalent to AAK47374 from Mycobacterium tuberculosis strain CDC1551 (309 aa) but longer 67 aa. Q7TXI8 No NC_002945.3 Mycobrowser_v2 CDS 4249039 4249815 . + 0 Mb3869 CONSERVED HYPOTHETICAL PROTEIN Mb3869, -, len: 258 aa. Equivalent to Rv3839, len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 258 aa overlap). Conserved hypothetical protein, similar in part to Q9RD78|SCF43.10cfrom HYPOTHETICAL 25.8 KDA PROTEIN Streptomyces coelicolor (241 aa), FASTA scores: opt: 270, E(): 3.2e-10, (33.45% identity in 272 aa overlap); and O00320|F25451_2 HYPOTHETICAL PROTEIN from Homo sapiens (Human) (339 aa),FASTA scores: opt: 126, E(): 0.77, (28.75% identity in 240 aa overlap). Q7TVJ5 No conserved hypotheticals Rv3839 NC_002945.3 Mycobrowser_v2 CDS 3283712 3284425 . - 0 Mb2997c POSSIBLE CONSERVED MEMBRANE OR EXPORTED PROTEIN Mb2997c, -, len: 237 aa. Equivalent to Rv2972c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Possible conserved membrane or exported protein, equivalent (but longer 52 aa) to O69461|MLCB1243.02 HYPOTHETICAL 20.5 KDA PROTEIN from Mycobacterium leprae (180 aa), FASTA scores: opt: 581, E(): 8.2e-32, (55.75% identity in 174 aa overlap). Also similar to membrane or exported proteins e.g. Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 498, E(): 4.1e-26,(44.08% identity in 186 aa overlap); Q99QB5|SCP1.323C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (219 aa), FASTA scores: opt: 329, E(): 8.5e-15, (36.35% identity in 176 aa overlap); Q9ACQ1|SCP1.267 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (219 aa),FASTA scores: opt: 286, E(): 6.6e-12, (32.03% identity in 231 aa overlap); etc. Q7TXI5 No cell wall and cell processes Rv2972c NC_002945.3 Mycobrowser_v2 CDS 3284422 3286635 . - 0 Mb2998c recG PROBABLE ATP-DEPENDENT DNA HELICASE RECG Mb2998c, recG, len: 737 aa. Equivalent to Rv2973c,len: 737 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 737 aa overlap). Probable recG,ATP-dependent DNA helicase (EC 3.6.1.-), equivalent to O69460|RECG_MYCLE ATP-DEPENDENT DNA HELICASE from Mycobacterium leprae (743 aa), FASTA scores: opt: 3846,E(): 0, (79.3% identity in 744 aa overlap). Also highly similar to others e.g. Q9ZBR3|SC7A1.10 PUTATIVE ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor (742 aa), FASTA scores: opt: 1249, E(): 1.1e-67, (46.2% identity in 758 aa overlap); Q9PGE8 ATP-DEPENDENT DNA HELICASE from Xylella fastidiosa (718 aa), FASTA scores: opt: 1174, E(): 3.5e-63, (42.1% identity in 539 aa overlap); P24230|RECG_ECOLI|RECG|B3652 from Escherichia coli strain K12 (693 aa), FASTA scores: opt: 457, E(): 7.3e-22, (35.2% identity in 733 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, RECG SUBFAMILY. X2BMQ8,P64323 No NC_002945.3 Mycobrowser_v2 CDS 3321324 3322445 . + 0 Mb3031 lppZ PROBABLE CONSERVED LIPOPROTEIN LPPZ Mb3031, lppZ, len: 373 aa. Equivalent to Rv3006,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 373 aa overlap). Probable lppZ,conserved lipoprotein, equivalent to O33109|MLCB637.17C|ML1699 putative lipoprotein from M. leprae (372 aa), FASTA scores: opt: 2211, E(): 4.3e-100,(87.1% identity in 373 aa overlap). Shows also similarity (in part) with Q9Z571|SC8D9.20c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (447 aa), FASTA scores: opt: 185, E(): 0.051, (31.6% identity in 300 aa overlap); Q9Z9R3|BH2090 GLUCOSE DEHYDROGENASE-B from Bacillus halodurans (371 aa), FASTA scores: opt: 206, E(): 0.0043,(28.3% identity in 205 aa overlap); and other GLUCOSE DEHYDROGENASES B. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, followed by a proline-rich domain. Q7TXG5 No cell wall and cell processes Rv3006 NC_002945.3 Mycobrowser_v2 CDS 3337239 3337553 . - 0 Mb3048c PE29 pe family protein pe29 Mb3048c, PE29, len: 104 aa. Equivalent to Rv3022A,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many others e.g. Rv0285|AL021930_12 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 497, E(): 3e-21,(80.39% identity in 102 aa overlap); etc. Q7TXF5 No NC_002945.3 Mycobrowser_v2 CDS 3286638 3288299 . - 0 Mb2999c conserved hypothetical protein Mb2999c, -, len: 553 aa. Equivalent to Rv2975c and Rv2974c, len: 84 aa and 470 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 83 aa overlap and 100.0% identity in 470 aa overlap). Rv2975c: Conserved hypothetical protein, similar to N-terminus of others e.g. Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA PROTEIN from Streptomyces coelicolor (589 aa), FASTA scores: opt: 141, E(): 0.0019, (41.25% identity in 80 aa overlap); Q98R49|MYPU_1610 HYPOTHETICAL PROTEIN from Mycoplasma pulmonis (545 aa), FASTA scores: opt: 127, E(): 0.023,(48.0% identity in 50 aa overlap); Q9K9Z6|BH2498 HYPOTHETICAL PROTEIN from Bacillus halodurans (557 aa),FASTA scores: opt: 126, E(): 0.028, (34.55% identity in 81 aa overlap); etc. Also some similarity with N-terminus of P47609|Y369_MYCGE|MG369 HYPOTHETICAL PROTEIN from Mycoplasma genitalium (557 aa), FASTA scores: opt: 108,E(): 0.7, (36.75% identity in 49 aa overlap); this, and preceding ORF, are similar to Y369_MYCGE and YLOV PROTEIN but no cosmid sequence error was identified. Rv2974c: Conserved hypothetical ala-rich protein, highly similar to others e.g. C-terminus of Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA PROTEIN from Streptomyces coelicolor (589 aa),FASTA scores: opt: 774, E(): 1.3e-36, (41.0% identity in 495 aa overlap); Q9K9Z6|BH2498 HYPOTHETICAL PROTEIN from Bacillus halodurans (557 aa), FASTA scores: opt: 268, E(): 8e-08, (27.7% identity in 502 aa overlap) (N-terminus longer 76 aa); Q9X293 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (497 aa), FASTA scores: opt: 265, E(): 1.1e-07, (24.9% identity in 470 aa overlap) (N-terminus longer 43 aa); etc. Also some similarity with P47609|Y369_MYCGE|MG369 HYPOTHETICAL PROTEIN from Mycoplasma genitalium (557 aa), FASTA scores: opt: 154,E(): 0.25, (20.25% identity in 489 aa overlap); this, and following ORF, are similar to Y369_MYCGE but no cosmid sequence error was identified. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis, a 2 bp deletion (cg-*) results in a single product that is more similar to Rv2974c. Q7TXI4 No conserved hypotheticals Rv2975c NC_002945.3 Mycobrowser_v2 CDS 3427960 3428397 . - 0 Mb3130c HYPOTHETICAL PROLINE-RICH PROTEIN Mb3130c, -, len: 145 aa. Equivalent to Rv3103c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Hypothetical unknown pro-rich protein, with some similarity to Proline-rich proteins e.g. Q39789 PROLINE-RICH CELL WALL PROTEIN from Gossypium hirsutum (Upland cotton) (214 aa), FASTA scores: opt: 267, E(): 0.00014, (40% identity in 110 aa overlap). Equivalent to AAK47525 from M. mycobacterium strain CDC1551 (158 aa) but shorter 13 aa. Q7TX89 No conserved hypotheticals Rv3103c NC_002945.3 Mycobrowser_v2 CDS 3288758 3289441 . - 0 Mb3000c ung PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG) Mb3000c, ung, len: 227 aa. Equivalent to Rv2976c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). Probable ung,uracil-DNA glycosylase (EC 3.2.2.-), equivalent to Q9CBS3 URACIL-DNA GLYCOSYLASE from Mycobacterium leprae (227 aa),FASTA scores: opt: 1394, E(): 8.8e-85, (88.1% identity in 227 aa overlap). Also highly similar to others e.g. Q9EX12 from Streptomyces coelicolor (225 aa), FASTA scores: opt: 1134, E(): 1.3e-67, (72.75% identity in 224 aa overlap); Q9K682|UNG_BACHD from Bacillus halodurans (224 aa), FASTA scores: opt: 652, E(): 8.9e-36, (45.5% identity in 222 aa overlap); P39615|UNG_BACSU from Bacillus subtilis (225 aa), FASTA scores: opt: 625, E(): 5.4e-34, (45.5% identity in 222 aa overlap); etc. BELONGS TO THE URACIL-DNA GLYCOSYLASE FAMILY. X2BMD5,P67072 No NC_002945.3 Mycobrowser_v2 CDS 3289474 3290475 . - 0 Mb3001c thiL PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE) Mb3001c, thiL, len: 333 aa. Equivalent to Rv2977c,len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 333 aa overlap). Possible thiL,thiamin-monophosphate kinase (EC ), equivalent to Q9CBS2 PROBABLE THIAMINE-MONOPHOSPHATE KINASE from Mycobacterium leprae (325 aa), FASTA scores: opt: 1738, E(): 4.5e-98,(80.9% identity in 314 aa overlap). Also highly similar to others e.g. Q9ZBR7|SC7A1.06 PUTATIVE THIAMINE MONPHOSPHATE KINASE from Streptomyces coelicolor (322 aa), FASTA scores: opt: 959, E(): 7.8e-51, (51.1% identity in 319 aa overlap); O05514|THIL_BACSU THIAMINE-MONOPHOSPHATE KINASE from Bacillus subtilis (325 aa), FASTA scores: opt: 476,E(): 1.5e-21, (35.15% identity in 273 aa overlap); P77785|THIL_ECOLI|THIL|B0417 THIAMINE-MONOPHOSPHATE KINASE from Escherichia coli strain K12 (325 aa), FASTA scores: opt: 418, E(): 5e-18, (36.9% identity in 282 aa overlap); etc. BELONGS TO THE THIAMINE-MONOPHOSPHATE KINASE FAMILY. Note that the start, as given, is in IS1538. Q7TXI3 No NC_002945.3 Mycobrowser_v2 CDS 3290472 3291851 . - 0 Mb3002c probable transposase Mb3002c, -, len: 459 aa. Equivalent to Rv2978c,len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable resolvase for IS1538, with low level matches to transposon resolvases; highly similar from aa 101 to YX1C_MYCTU|Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 809, E(): 0, (69.1% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site, and possible helix-turn-helix motiv at aa 2-23. Q7TXI2 No insertion seqs and phages Rv2978c NC_002945.3 Mycobrowser_v2 CDS 3294555 3295559 . - 0 Mb3006c gpdA2 PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA2 (NAD(P)H-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) Mb3006c, gpdA2, len: 334 aa. Equivalent to Rv2982c,len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 334 aa overlap). Probable gpdA2 (alternate gene name: gpsA), glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94), equivalent to Q9CBR9|GPDA_MYCLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] from Mycobacterium leprae (349 aa), FASTA scores: opt: 1686, E(): 1.7e-95, (77.95% identity in 349 aa overlap). Also highly similar to others e.g. Q9ZBS0|GPDA_STRCO from Streptomyces coelicolor (336 aa),FASTA scores: opt: 1165, E(): 9.8e-64, (56.25% identity in 327 aa overlap); P46919|GPDA_BACSU from Bacillus subtilis (345 aa), FASTA scores: opt: 872, E(): 7.5e-46, (44.9% identity in 325 aa overlap); P37606|GPDA_ECOLI|GPSA|B3608|Z5035|ECS4486. from Escherichia coli strain O157:H7 and K12 (339 aa), FASTA scores: opt: 799, E(): 2.1e-41, (42.9% identity in 331 aa overlap); etc. Also highly similar to O53761|GPD2_MYCTU PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE from Mycobacterium tuberculosis (341 aa), FASTA scores: opt: 740, E(): 8.4e-38, (40.35% identity in 322 aa overlap). BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY. X2BM95,P59961 No NC_002945.3 Mycobrowser_v2 CDS 3295678 3296322 . + 0 Mb3007 CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN Mb3007, -, len: 214 aa. Equivalent to Rv2983, len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical ala-rich protein, equivalent to O33128|ML1680|MLCB637.37c HYPOTHETICAL 22.0 KDA PROTEIN from Mycobacterium leprae (216 aa), FASTA scores: opt: 1080, E(): 9e-61, (79.05% identity in 215 aa overlap). Also similar to other hypothetical proteins e.g. Q9ZBS2|SC7A1.01C from Streptomyces coelicolor (212 aa),FASTA scores: opt: 420, E(): 2.9e-19, (43.5% identity in 207 aa overlap); O26710|MTH613 from Methanothermobacter thermautotrophicus (223 aa), FASTA scores: opt: 193, E(): 5.8e-05, (30.0% identity in 190 aa overlap); Q9RKG8|SCE46.21 from Streptomyces coelicolor (210 aa),FASTA scores: opt: 139, E(): 0.14, (27.65% identity in 206 aa overlap); etc. X2BMR6,Q7TXH8 No conserved hypotheticals Rv2983 NC_002945.3 Mycobrowser_v2 CDS 3296414 3298642 . + 0 Mb3008 ppk polyphosphate kinase ppk (polyphosphoric acid kinase) (atp-polyphosphate phosphotransferase) Mb3008, ppk, len: 742 aa. Equivalent to Rv2984,len: 742 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 742 aa overlap). Probable ppk,polyphosphate kinase (EC 2.7.4.1), equivalent to O33127|PPK_MYCLE POLYPHOSPHATE KINASE from Mycobacterium leprae (739 aa), FASTA scores: opt: 4264, E(): 0, (87.85% identity in 742 aa overlap). Also highly similar to others e.g. Q9KZV6|PPK_STRCO from Streptomyces coelicolor (746 aa), FASTA scores: opt: 1979, E(): 2.6e-117, (59.9% identity in 701 aa overlap); Q9KD27|PPK_BACHD from Bacillus halodurans (705 aa), FASTA scores: opt: 1319,E(): 1.4e-75, (45.55% identity in 674 aa overlap); Q9PAC7|PPK_XYLFA from Xylella fastidiosa (698 aa), FASTA scores: opt: 1300, E(): 2.2e-74, (43.3% identity in 693 aa overlap); etc. BELONGS TO THE POLYPHOSPHATE KINASE FAMILY. X2BN16,P65769 No intermediary metabolism and respiration Rv2984 NC_002945.3 Mycobrowser_v2 CDS 3301214 3302635 . - 0 Mb3012c leuC PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) Mb3012c, leuC, len: 473 aa. Equivalent to Rv2988c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 473 aa overlap). Probable leuC,3-isopropylmalate dehydratase, large subunit (EC 4.2.1.33), equivalent to O33123|LEU2_MYCLE 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT from Mycobacterium leprae (476 aa), FASTA scores: opt: 2818,E(): 1.3e-171, (88.75% identity in 471 aa overlap). Also highly similar to many e.g. Q44427|LEU2_ACTTI from Actinoplanes teichomyceticus (485 aa), FASTA scores: opt: 1958, E(): 6.5e-117, (71.0% identity in 479 aa overlap); P55251|LEU2_RHIPU from Rhizomucor pusillus (755 aa), FASTA scores: opt: 1937, E(): 1.9e-115, (61.25% identity in 467 aa overlap) (C-terminus longer); P30127|LEU2_ECOLI|LEUC|B0072 from Escherichia coli strain K12 (465 aa), FASTA scores: opt: 1896, E(): 5.5e-113,(61.6% identity in 456 aa overlap); etc. Contains PS00450 Aconitase family signature. BELONGS TO THE ACONITASE/IPM ISOMERASE FAMILY. TBparse score is 0.895. X2BMS1,Q7TXH6 No NC_002945.3 Mycobrowser_v2 CDS 3314217 3315182 . + 0 Mb3024 lppY PROBABLE CONSERVED LIPOPROTEIN LPPY Mb3024, lppY, len: 321 aa. Equivalent to Rv2999,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 321 aa overlap). Probable lppY,conserved lipoprotein, highly similar to O07774|LPQO|Rv0604|MTCY19H5.18c PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (316 aa), FASTA scores: opt: 1153, E(): 5e-62, (53.2% identity in 312 aa overlap); and showing similarity with AAK80743|CAC2799 UNCHARACTERIZED CONSERVED PROTEIN SIMILAR TO LPPY/LPQO OF Mycobacterium tuberculosis from Clostridium acetobutylicum (152 aa),FASTA scores: opt: 165, E(): 0.0077, (26.08% identity in 138 aa overlap); and Q9F2T1|SCD65.01c PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (146 aa), FASTA scores: opt: 126, E(): 1.6, (% identity in aa overlap). Equivalent to AAK47407 from Mycobacterium tuberculosis strain CDC1551 (329 aa) but shorter 8 aa. Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TXG8 No cell wall and cell processes Rv2999 NC_002945.3 Mycobrowser_v2 CDS 3302707 3303408 . + 0 Mb3013 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb3013, -, len: 233 aa. Equivalent to Rv2989, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Probable transcriptional regulator (ala-rich protein), highly similar to O86533|SC1C2.33c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (238 aa), FASTA scores: opt: 711, E(): 2.3e-38, (53.05% identity in 230 aa overlap); and similar to others e.g. Q9KND6 PUTATIVE TRANSCRIPTIONAL REGULATOR from Vibrio cholerae (244 aa),FASTA scores: opt: 232, E(): 1.2e-07, (29.75% identity in 232 aa overlap); Q9R9U0|SRPS EFFLUX PUMP REGULATOR from Pseudomonas putida (259 aa), FASTA scores: opt: 224, E(): 4.1e-07, (28.35% identity in 247 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O06806|Rv1773c|MTCY28.39 HYPOTHETICAL 26.6 KDA PROTEIN (248 aa), FASTA scores: opt: 239, E(): 4.4e-08, (29.85% identity in 231 aa overlap); P71977|RV1719|MTCY04C12.04 HYPOTHETICAL 27.9 KDA PROTEIN (259 aa), FASTA scores: opt: 215, E(): 1.6e-06, (31.85% identity in 223 aa overlap); etc. Equivalent to AAK47396 from Mycobacterium tuberculosis strain CDC1551 (267 aa) but shorter 34 aa. Contains possible helix-turn-helix motif at aa 25-46 (Score 1005, +2.61 SD). Q7TXH5 No regulatory proteins Rv2989 NC_002945.3 Mycobrowser_v2 CDS 3298725 3299678 . + 0 Mb3009 mutT1 POSSIBLE HYDROLASE MUTT1 Mb3009, mutT1, len: 317 aa. Equivalent to Rv2985,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Possible mutT1, long mutt protein (hydrolase) (EC 3.-.-.-), highly similar to O33126|MLCB637.35 HYPOTHETICAL 34.5 KDA PROTEIN from Mycobacterium leprae (312 aa), FASTA scores: opt: 1514,E(): 5.1e-91, (71.85% identity in 316 aa overlap); and Q9CBR8|ML1682 HYPOTHETICAL PROTEIN from Mycobacterium leprae (311 aa), FASTA scores: opt: 1510, E(): 9.2e-91,(71.5% identity in 316 aa overlap). Also similar to Q50195|L222-ORF6|ML2698 HYPOTHETICAL PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 231,E(): 1.1e-07, (36.7% identity in 128 aa overlap). Also similar to shorter mutt proteins and related hypothetical protein e.g. Q9EUS6 HYPOTHETICAL 16.6 KDA PROTEIN from Streptomyces griseus subsp. griseus (152 aa), FASTA scores: opt: 380, E(): 1.7e-17, (50.75% identity in 130 aa overlap); Q9KZV8|SCD84.10C PUTATIVE MUTT-LIKE PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 376,E(): 2.9e-17, (46.1% identity in 128 aa overlap); P96590|MUTT MUTT PROTEIN from Bacillus subtilis (149 aa),FASTA scores: opt: 180, E(): 0.00017, (35.25% identity in 122 aa overlap); etc. Also similar to O05437 HYPOTHETICAL 27.1 KDA PROTEIN from Mycobacterium tuberculosis (248 aa),FASTA scores: opt: 224, E(): 3.2e-07, (34.03% identity in 144 aa overlap). Contains PS00893 mutT domain signature. SEEMS TO BELONG TO THE MUTT/NUDIX FAMILY PROTEIN. Q7TXH7 No NC_002945.3 Mycobrowser_v2 CDS 3299736 3300380 . - 0 Mb3010c hupB dna-binding protein hu homolog hupb (histone-like protein) (hlp) (21-kda laminin-2-binding protein) Mb3010c, hupB, len: 214 aa. Equivalent to Rv2986c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable hupB (alternate gene names: hup, hlp, lbp21), DNA-binding protein HU homolog (resembles fusion between HU and histone) (see first citation below), equivalent to others from Mycobacteria e.g. Q9XB18|DBH_MYCBO from Mycobacterium bovis (205 aa), FASTA scores: opt: 1050, E(): 5.6e-45,(95.35% identity in 214 aa overlap); Q9ZHC5|DBH_MYCSM from Mycobacterium smegmatis (208 aa), FASTA scores: opt: 1035,E(): 3.1e-44, (80.2% identity in 217 aa overlap); and O33125|DBH_MYCLE from Mycobacterium leprae (200 aa), FASTA scores: opt: 914, E(): 2.7e-38, (80.1% identity in 216 aa overlap). Also highly similar to others from other organisms e.g. O86537|DBH2_STRCO from Streptomyces coelicolor (218 aa), FASTA scores: opt: 569, E(): 2.6e-21,(51.35% identity in 220 aa overlap); P08821|DBH1_BACSU from Bacillus subtilis (92 aa), FASTA scores: opt: 280,E(): 2.5e-07, (45.05% identity in 91 aa overlap) (C-terminus shorter); etc. Contains PS00045 Bacterial histone-like DNA-binding proteins signature. BELONGS TO THE BACTERIAL HISTONE-LIKE PROTEIN FAMILY. Note that its C-terminal domain is very rich in lysine and alanine. X2BME1,Q9XB18 No NC_002945.3 Mycobrowser_v2 CDS 3306834 3307553 . - 0 Mb3017c POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE) Mb3017c, -, len: 239 aa. Equivalent to Rv2993c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-), equivalent to O33119|ML1689|MLCB637.28 POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE- 1,7-DIOATE ISOMERASE from Mycobacterium leprae (242 aa), FASTA scores: opt: 1427,E(): 4.4e-86, (85.9% identity in 241 aa overlap). Also similar to others e.g. Q9LBE3|DR1609 from Deinococcus radiodurans (250 aa), FASTA scores: opt: 723, E(): 5.5e-40, (49.05% identity in 216 aa overlap); O27551|MTH1507 from Methanothermobacter thermautotrophicus (260 aa), FASTA scores: opt: 708, E(): 5.4e-39, (52.1% identity in 213 aa overlap); Q9HQR6|VNG1037G|HPCE from Halobacterium sp. (strain NRC-1) (244 aa), FASTA scores: opt: 590, E(): 2.7e-31, (43.65% identity in 220 aa overlap); etc. Start chosen by homology, but ORF could continue upstream. TBparse score is 0.896. Q7TXH2 No intermediary metabolism and respiration Rv2993c NC_002945.3 Mycobrowser_v2 CDS 3300593 3301189 . - 0 Mb3011c leuD PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) LEUD (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) Mb3011c, leuD, len: 198 aa. Equivalent to Rv2987c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 198 aa overlap). Probable leuD,3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33), equivalent to O33124|LEUD_MYCLE 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT from Mycobacterium leprae (198 aa), FASTA scores: opt: 1155,E(): 4.2e-72, (87.75% identity in 196 aa overlap). Also highly similar to many e.g. O86535|LEUD_STRCO from Streptomyces coelicolor (197 aa), FASTA scores: opt: 765,E(): 2.6e-45, (59.0% identity in 195 aa overlap); P04787|LEUD_SALTY from Salmonella typhimurium (201 aa),FASTA scores: opt: 528, E(): 5.2e-29, (45.05% identity in 191 aa overlap); P30126|LEUD_ECOLI|LEUD|B0071 from Escherichia coli strain K12 (201 aa), FASTA scores: opt: 498, E(): 6e-27, (43.45% identity in 191 aa overlap); etc. TBparse score is 0.939. X2BM97,P65278 No NC_002945.3 Mycobrowser_v2 CDS 3353018 3353701 . - 0 Mb3062c TB22.2 PROBABLE CONSERVED SECRETED PROTEIN TB22.2 Mb3062c, TB22.2, len: 227 aa. Equivalent to Rv3036c, len: 227 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 227 aa overlap). Probable TB22.2, conserved secreted protein, with putative N-terminal signal peptide, highly similar to secreted immunogenic protein MPT64/MPB64 P19996|Rv1980c|MTCY39.39 from Mycobacterium tuberculosis and Mycobacterium bovis (228 aa), FASTA scores: opt: 681, E(): 2.5e-35, (45.8% identity in 227 aa overlap). Q7TXE4 No cell wall and cell processes Rv3036c NC_002945.3 Mycobrowser_v2 CDS 3304542 3305033 . + 0 Mb3015 conserved protein Mb3015, -, len: 163 aa. Equivalent to Rv2991, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 163 aa overlap). Conserved hypothetical protein, similar to others e.g. Q9K3X7|2SCG61.39. HYPOTHETICAL 17.6 KDA PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 HYPOTHETICAL PROTEIN from Pasteurella multocida (171 aa), FASTA scores: opt: 175, E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163, E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06553|MTCI65.22|Rv1155 hypothetical protein from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 127, E(): 0.1, (32.9% identity in 73 aa overlap); and to several proteins of similar size that confer resistance to 5-Nitroimidazole antibiotics in Bacteroides. Q7TXH3 No conserved hypotheticals Rv2991 NC_002945.3 Mycobrowser_v2 tRNA 3305107 3305179 . - 0 gluU gluU tRNA-Glu gluU, len: 73 nt. Equivalent to gluU, len: 73 nt,from Mycobacterrium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Glu; anticodon ctc. No NC_002945.3 Mycobrowser_v2 tRNA 3305219 3305290 . - 0 glnU glnU tRNA-Gln glnU, len: 72 nt. Equivalent to glnU, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Gln; anticodon ctg. No NC_002945.3 Mycobrowser_v2 CDS 3305365 3306837 . - 0 Mb3016c gltS glutamyl-trna synthetase glts (glutamate--trna ligase) (glutamyl-trna synthase) (glurs) Mb3016c, gltS, len: 490 aa. Equivalent to Rv2992c,len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 490 aa overlap). Probable gltS (alternate gene name: gltX), glutamyl-tRNA synthase (EC 6.1.1.17), equivalent to O33120|SYE_MYCLE GLUTAMYL-TRNA SYNTHETASE from Mycobacterium leprae (502 aa), FASTA scores: opt: 2660, E(): 2.3e-163, (81.35% identity in 488 aa overlap). Also highly similar to others e.g. O86528|SYE_STRCO from Streptomyces coelicolor (494 aa),FASTA scores: opt: 1777, E(): 1.4e-106, (57.45% identity in 484 aa overlap); P22250|SYE_BACSU from Bacillus subtilis (483 aa), FASTA scores: opt: 1099, E(): 5.4e-63,(38.45% identity in 489 aa overlap); O51345|SYE_BORBU|GLTX|BB0372 from Borrelia burgdorferi (Lyme disease spirochete) (490 aa), FASTA scores: opt: 1009, E(): 3.3e-57, (34.85% identity in 491 aa overlap); etc. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. TBparse score is 0.891. X2BMA1,P0A637 No NC_002945.3 Mycobrowser_v2 CDS 3309074 3310084 . - 0 Mb3019c leuB probable 3-isopropylmalate dehydrogenase leub (beta-ipm dehydrogenase) (imdh) (3-ipm-dh) Mb3019c, leuB, len: 336 aa. Equivalent to Rv2995c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 336 aa overlap). leuB,3-isopropylmalate dehydrogenase (EC 1.1.1.85) (see citation below), identical except one bp to P94929|LEU3_MYCBO 3-ISOPROPYLMALATE DEHYDROGENASE from Mycobacterium bovis (336 aa), FASTA scores: opt: 2168,E(): 5.1e-132, (99.7% identity in 336 aa overlap); and equivalent to O33117|LEU3_MYCLE 3-ISOPROPYLMALATE DEHYDROGENASE from Mycobacterium leprae (336 aa), FASTA scores: opt: 1864, E(): 1.8e-112, (83.95% identity in 336 aa overlap). Also highly similar to others e.g. P94631|LEU3_CORGL from Corynebacterium glutamicum (340 aa), FASTA scores: opt: 1526, E(): 1e-90, (69.9% identity in 339 aa overlap); O86504 from Streptomyces coelicolor (347 aa), FASTA scores: opt: 1470, E(): 4.2e-87, (67.85% identity in 339 aa overlap); Q9UZ05|PAB2424 from Pyrococcus abyssi (354 aa), FASTA scores: opt: 998, E(): 1e-56, (50.0% identity in 322 aa overlap); etc. Note that also shows high similarity with many tartrate dehydrogenases (EC 1.1.1.93). BELONGS TO THE ISOCITRATE AND ISOPROPYLMALATE DEHYDROGENASES FAMILY. X2BM37,P94929 No NC_002945.3 Mycobrowser_v2 CDS 3310099 3311685 . - 0 Mb3020c serA1 PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) Mb3020c, serA1, len: 528 aa. Equivalent to Rv2996c,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 528 aa overlap). Probable serA1,D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95),equivalent to SERA_MYCLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE from Mycobacterium leprae (528 aa), FASTA scores: opt: 2974, E(): 1.9e-166, (89.6% identity in 528 aa overlap). Also highly similar to many e.g. Q9Z564 from Streptomyces coelicolor (529 aa), FASTA scores: opt: 1879,E(): 2.1e-102, (57.6% identity in 526 aa overlap); O29445|SERA_ARCFU from Archaeoglobus fulgidus (527 aa),FASTA scores: opt: 1252, E(): 9.6e-66, (41.3% identity in 530 aa overlap); P35136|SERA_BACSU from Bacillus subtilis (525 aa), FASTA scores: opt: 1172, E(): 4.5e-61, (37.9% identity in 528 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature, and PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. BELONGS TO THE D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASES FAMILY. Note that previously known as serA. X2BME8,P0A545 No NC_002945.3 Mycobrowser_v2 CDS 3311715 3313157 . + 0 Mb3021 POSSIBLE ALANINE RICH DEHYDROGENASE Mb3021, -, len: 480 aa. Equivalent to Rv2997, len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 480 aa overlap). Possible ala-rich dehydrogenase (EC 1.-.-.-), similar to others dehydrogenases and hypothetical proteins e.g. Q9EYI5 PUTATIVE DEHYDROGENASE from Streptomyces nogalater (472 aa), FASTA scores: opt: 1131, E(): 1.7e-61, (41.0% identity in 471 aa overlap); Q9ZBG4|SC9B5.16 PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (472 aa), FASTA scores: opt: 1064, E(): 2e-57, (39.05% identity in 471 aa overlap); Q98BS8 PROBABLE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (524 aa), FASTA scores: opt: 196, E(): 0.00021, (25.1% identity in 526 aa overlap); etc. Shows strong simlarity throughout its length to O06826|MTCY493.22c|Rv1432 HYPOTHETICAL 50.5 KDA PROTEIN from Mycobacterium tuberculosis (473 aa), FASTA scores: opt: 1220, E(): 6.1e-67, (42.35% identity in 465 aa overlap). Q7TXH1 No intermediary metabolism and respiration Rv2997 NC_002945.3 Mycobrowser_v2 CDS 3313430 3313891 . + 0 Mb3022 HYPOTHETICAL PROTEIN Mb3022, -, len: 153 aa. Equivalent to Rv2998, len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Hypothetical unknown protein. Note that equivalent to AAK47405 Hypothetical 19.4 kDa protein from Mycobacterium tuberculosis strain CDC1551 (186 aa) but sequence differs in N-terminus. Q7TXH0 No conserved hypotheticals Rv2998 NC_002945.3 Mycobrowser_v2 CDS 3313840 3314043 . - 0 Mb3023c CONSERVED HYPOTHETICAL PROTEIN Mb3023c, -, len: 67 aa. Equivalent to Rv2998A, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable conserved hypothetical protein, (possibly gene fragment), highly similar to central part of two-component sensor proteins e.g. O07777|Rv0601c|MTCY19H5.21 TWO COMPONENT SENSOR (FRAGMENT) from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 212, E(): 3.7e-09, (58.2% identity in 67 aa overlap); Q9L2B6|SC8F4.08 PROBABLE TWO-COMPONENT SENSOR KINASE from Streptomyces coelicolor (478 aa), FASTA scores: opt: 193, E(): 2.6e-07, (47.05% identity in 68 aa overlap); etc. Q7TXG9 No conserved hypotheticals Rv2998A NC_002945.3 Mycobrowser_v2 CDS 3320308 3321147 . - 0 Mb3030c CONSERVED HYPOTHETICAL PROTEIN Mb3030c, -, len: 279 aa. Equivalent to Rv3005c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Conserved hypothetical protein, equivalent to O33110|MLCB637.18|ML1698 HYPOTHETICAL 29.5 KDA PROTEIN from Mycobacterium leprae (277 aa), FASTA scores: opt: 1245, E(): 1.2e-65, (70.5% identity in 278 aa overlap). Also similar, but longer 100 aa in N-terminus, to other hypothetical proteins, few membrane proteins, e.g. Q9RKN9|SCC75A.35 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 326,E(): 3.9e-12, (44.2% identity in 138 aa overlap); P96694|YDFP|AB001488 HYPOTHETICAL PROTEIN from Bacillus subtilis (129 aa), FASTA scores: opt:273, E(): 3.7e-09,(33.1% identity in 130 aa overlap); Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from Vibrio cholerae (148 aa), FASTA scores: opt: 258, E(): 3.1e-08, (34.9% identity in 126 aa overlap); etc. Q7TXG6 No conserved hypotheticals Rv3005c NC_002945.3 Mycobrowser_v2 CDS 3315227 3315886 . + 0 Mb3025 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb3025, -, len: 219 aa. Equivalent to Rv3000, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Possible conserved transmembrane protein, similar to various membrane proteins e.g. P77307|YBBM_ECOLI|B0491 HYPOTHETICAL 28.2 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain K12 (259 aa), FASTA scores: opt: 292, E(): 3.1e-11, (30.25% identity in 218 aa overlap); N-terminus of Q9BJF3 PUTATIVE ABC TRANSPORTER (FRAGMENT) from Sterkiella histriomuscorum (1319 aa), FASTA scores: opt: 274, E(): 1.3e-09, (39.6% identity in 101 aa overlap); Q9C9W0|T23K23.21 PUTATIVE ABC TRANSPORTER from Arabidopsis thaliana (Mouse-ear cress) (263 aa), FASTA scores: opt: 258, E(): 4.4e-09, (30.1% identity in 196 aa overlap); P74369|YG47_SYNY3|SLR1647 HYPOTHETICAL 28.1 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Synechocystis sp. strain PCC 6803 (259 aa), FASTA scores: opt: 257, E(): 5.1e-09, (37.75% identity in 98 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TXG7 No cell wall and cell processes Rv3000 NC_002945.3 Mycobrowser_v2 CDS 3316200 3317201 . - 0 Mb3026c ilvC PROBABLE KETOL-ACID REDUCTOISOMERASE ILVC (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase) Mb3026c, ilvC, len: 333 aa. Equivalent to Rv3001c,len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 333 aa overlap). Probable ilvC,ketol-acid reductoisomerase (EC 1.1.1.86), equivalent or highly similar to others e.g. Q59500|ILVC_MYCAV from Mycobacterium avium (333 aa), FASTA scores: opt: 1977,E(): 3.2e-113, (87.7% identity in 333 aa overlap); O33114|ILVC_MYCLE from Mycobacterium leprae (333 aa),FASTA scores: opt: 1924, E(): 5.3e-110, (86.5% identity in 333 aa overlap); Q9Z565|ILVC_STRCO|SC8D9.26 from Streptomyces coelicolor (332 aa), FASTA scores: opt: 1494,E(): 8.3e-84, (67.5% identity in 326 aa overlap); Q59818|ILVC_STRAW from Streptomyces avermitilis (333 aa) FASTA scores: opt: 1487, E(): 2.2e-83, (66.8% identity in 326 aa overlap); etc. BELONGS TO THE KETOL-ACID REDUCTOISOMERASES FAMILY. X2BMA8,P65150 No NC_002945.3 Mycobrowser_v2 CDS 3317239 3317745 . - 0 Mb3027c ilvN PROBABLE ACETOLACTATE SYNTHASE (SMALL SUBUNIT) ILVN (ACETOHYDROXY-ACID SYNTHASE) (AHAS) (ALS) Mb3027c, ilvN, len: 168 aa. Equivalent to Rv3002c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Probable ilvN (alternate gene name: ilvH), acetolactate synthase, small subunit (EC 4.1.3.18), equivalent or highly similar to others e.g. O33113|ILVH_MYCLE|MLCB637.21 from Mycobacterium leprae (169 aa), FASTA scores: opt: 843,E(): 5.1e-47, (83.5% identity in 164 aa overlap); Q59499|ILVH_MYCAV|ILVN from Mycobacterium avium (167 aa),FASTA scores: opt: 798, E(): 3.7e-44, (81.05% identity in 169 aa overlap); Q9Z566|ILVN from Streptomyces coelicolor (174 aa), FASTA scores: opt: 678, E(): 1.7e-36, (64.8% identity in 159 aa overlap); etc. BELONGS TO THE ACETOLACTATE SYNTHASE SMALL SUBUNIT FAMILY. X2BMT4,P65162 No NC_002945.3 Mycobrowser_v2 CDS 3317745 3319601 . - 0 Mb3028c ilvB1 acetolactate synthase (large subunit) ilvb1 (acetohydroxy-acid synthase) Mb3028c, ilvB1, len: 618 aa. Equivalent to Rv3003c,len: 618 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 618 aa overlap). Probable ilvB1,acetolactate synthase, large subunit (EC 4.1.3.18),equivalent or highly similar to others e.g. O33112|ILVB_MYCLE|MLCB637.20|ML1696 from Mycobacterium leprae (625 aa), FASTA scores: opt: 3653, E(): 5.4e-208,(87.1% identity in 627 aa overlap); Q59498|ILVB_MYCAV from Mycobacterium avium (621 aa), FASTA scores: opt: 3473,E(): 2.3e-197, (84.7% identity in 614 aa overlap); P42463|ILVB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (626 aa), FASTA scores: opt: 2754,E(): 5.9e-155, (65.8% identity in 589 aa overlap); etc. Contains PS00187 Thiamine pyrophosphate enzymes signature. COFACTOR: THIAMINE PYROPHOSPHATE, AND MAGNESIUM (BY SIMILARITY). Note that previously known as ilvB. X2BN34,P0A623 No NC_002945.3 Mycobrowser_v2 CDS 3319963 3320301 . + 0 Mb3029 cfp6 LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 6 (CFP-6) Mb3029, cfp6, len: 112 aa. Equivalent to Rv3004,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). cfp6, low molecular weight protein antigen 6 (CFP-6) (cf note * below). Weak homology with Q9RKZ5|SC6D7.02 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (156 aa), FASTA scores: opt: 109, E(): 0.78, (39.4% identity in 122 aa overlap). CAUTION: THE INITIATOR METHIONINE MAY BE FURTHER UPSTREAM MAKING THE SEQUENCE A PRECURSOR. [* Note: Bhaskar S.,Mukherjee R.: Isolation, purification and immunological characterization of low molecular weight protein antigens from culture filtrate of Mycobacterium tuberculosis H37Rv. Unpublished. Submitted (NOV-1998) to the SWISS-PROT data bank]. X2BM45,P0A5P3 No cell wall and cell processes Rv3004 NC_002945.3 Mycobrowser_v2 CDS 3353774 3354850 . - 0 Mb3063c CONSERVED HYPOTHETICAL PROTEIN Mb3063c, -, len: 358 aa. Equivalent to Rv3037c,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 358 aa overlap). Conserved hypothetical protein, similar in part to others e.g. O86799|SC6G4.36c from Streptomyces coelicolor (426 aa), FASTA scores: opt: 545, E(): 5.5e-27, (36.15% identity in 354 aa overlap); Q9UZW6|PAB0687 from Pyrococcus abyssi (386 aa), FASTA scores: opt: 262, E(): 3.5e-09, (31.0% identity in 200 aa overlap). Q7TXE3 No conserved hypotheticals Rv3037c NC_002945.3 Mycobrowser_v2 CDS 3322451 3323065 . - 0 Mb3032c POSSIBLE OXIDOREDUCTASE Mb3032c, -, len: 204 aa. Equivalent to Rv3007c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to Q9EWU5|3SC5B7.04c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (162 aa), FASTA scores: opt: 376, E(): 1.5e-18, (41.35% identity in 150 aa overlap); Q9K416|SCG22.29c PUTATIVE FLAVIN-DEPENDENT REDUCTASE PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 246, E(): 1e-09,(34.1% identity in 135 aa overlap); and some similarity to coupling proteins of 4-hydroxyphenylacetic hydroxylase/monooxygenase e.g. Q9HWT6|HPAC|PA4092 Pseudomonas aeruginosa (170 aa), FASTA score: opt: 214; O68232|HPAC Photorhabdus luminescens (Xenorhabdus luminescens) (172 aa), FASTA score: opt: 198; Q9RPU2|HPAC Salmonella dublin (170 aa), FASTA score: opt: 197; etc. Equivalent to AAK47416 from Mycobacterium tuberculosis strain CDC1551 (236 aa) but shorter 32 aa. Start chosen by similarity. Q7TXG4 No intermediary metabolism and respiration Rv3007c NC_002945.3 Mycobrowser_v2 CDS 3424960 3425811 . - 0 Mb3126c conserved protein Mb3126c, -, len: 283 aa. Equivalent to Rv3099c,len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Conserved hypothetical protein, some similarity with hypothetical proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 384, E(): 1.8e-17, (32.7% identity in 269 aa overlap); and P71606|Y036_MYCTU|Rv0036c from Mycobacterium tuberculosis strain H37Rv (257 aa),FASTA scores: opt: 179, E(): 0.00024, (25.85% identity in 205 aa overlap). Q7TX92 No conserved hypotheticals Rv3099c NC_002945.3 Mycobrowser_v2 CDS 3323879 3325408 . - 0 Mb3034c gatB PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT B) GATB (Glu-ADT SUBUNIT B) Mb3034c, gatB, len: 509 aa. Equivalent to Rv3009c,len: 509 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 509 aa overlap). Probable gatB,Glu-tRNA-Gln amidotransferase, subunit B (EC 6.3.5.-),equivalent to O33107|GATB_MYCLE|MLCB637_15 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Mycobacterium leprae (509 aa), FASTA scores: opt: 2973, E(): 2.9e-173,(88.4% identity in 509 aa overlap). Also highly similar to other Glu- tRNA-Gln amidotransferases e.g. Q9Z578|GATB|SC8D9.13 from Streptomyces coelicolor (504 aa), FASTA scores: opt: 2264, E(): 3.6e-130, (66.0% identity in 495 aa overlap); P74215|GATB_SYNY3|SLL1435 from Synechocystis sp. strain PCC 6803 (519 aa), FASTA scores: opt: 1289, E(): 6.7e-71, (42.0% identity in 485 aa overlap); Q9X100|GATB_THEMA|TM1273 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Thermotoga maritima (482 aa), FASTA scores: opt: 1165, E(): 2.2e-63, (40.05% identity in 487 aa overlap); etc. For more information about function, see citation below. Similar to many members of the pet112 family. BELONGS TO THE GATB FAMILY. X2BM48,P64200 No NC_002945.3 Mycobrowser_v2 CDS 3325438 3326469 . - 0 Mb3035c pfkA PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Mb3035c, pfkA, len: 343 aa. Equivalent to Rv3010c,len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 343 aa overlap). Probable pfkA,phosphofructokinase (EC 2.7.1.11), equivalent to O33106|K6PF_MYCLE|MLCB637.14 6-PHOSPHOFRUCTOKINASE from Mycobacterium leprae (343 aa), FASTA scores: opt: 2099,E(): 4.1e-122, (90.4% identity in 343 aa overlap). Also highly similar to others e.g. Q9FC99|K6P3_STRCO from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1329,E(): 1.1e-74, (58.9% identity in 338 aa overlap); Q9L1L8|K6P2_STRCO|PFKA2|PFK2|SC6A11.02 6-PHOSPHOFRUCTOKINASE 2 from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1303, E(): 4.5e-73, (56.7% identity in 342 aa overlap); Q9KH71|PFP PPI-DEPENDENT PHOSPHOFRUCTOKINASE from Dictyoglomus thermophilum (346 aa), FASTA scores: opt: 893, E(): 8.4e-48, (41.85% identity in 344 aa overlap); etc. Contains PS00433 Phosphofructokinase signature. BELONGS TO THE PHOSPHOFRUCTOKINASE FAMILY. X2BMF7,P65691 No NC_002945.3 Mycobrowser_v2 CDS 3326565 3328049 . - 0 Mb3036c gatA PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) Mb3036c, gatA, len: 494 aa. Equivalent to Rv3011c,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 494 aa overlap). Probable gatA,Glu-tRNA-Gln amidotransferase, subunit A (EC 6.3.5.-),equivalent to O33105|GATA|ML1702|MLCB637.13 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Mycobacterium leprae (497 aa), FASTA scores: opt: 2839, E(): 3.5e-161,(88.8% identity in 492 aa overlap). Also highly similar to other Glu-tRNA-Gln amidotransferases e.g. Q9Z580|GATA_STRCO from Streptomyces coelicolor (497 aa),FASTA scores: opt: 2231, E(): 4.5e-125, (70.3% identity in 486 aa overlap); P73558|GATA_SYNY3|SLR0877 from Synechocystis sp. strain PCC 6803 (483 aa), FASTA scores: opt: 1593, E(): 3.3e-87, (55.85% identity in 487 aa overlap); O06491|GATA_BACSU GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Bacillus subtilis (485 aa), FASTA scores: opt: 1389, E(): 4.3e-75, (51.7% identity in 468 aa overlap); etc. For more information about function, see citation below. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE AMIDASE FAMILY. X2BMB5,Q7TXG2 No NC_002945.3 Mycobrowser_v2 CDS 3414758 3415645 . + 0 Mb3117 unknown alanine and valine rich protein Mb3117, -, len: 295 aa. Equivalent to Rv3090, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Hypothetical unknown Ala-, Val-rich protein. Hydrophobic stretch at N-terminus. Q7TXA0 No conserved hypotheticals Rv3090 NC_002945.3 Mycobrowser_v2 CDS 3328046 3328345 . - 0 Mb3037c gatC PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT C) GATC (Glu-ADT SUBUNIT C) Mb3037c, gatC, len: 99 aa. Equivalent to Rv3012c,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Probable gatC,Glu-tRNA-Gln amidotransferase, subunit C (EC 6.3.5.-),equivalent to O33104|GATC_MYCLE|MLCB637.12 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Mycobacterium leprae (99 aa), FASTA scores: opt: 483, E(): 3.1e-25,(74.75% identity in 99 aa overlap). Also highly similar to other Glu-tRNA-Gln amidotransferases e.g. Q9Z581|GATC_STRCO|SC8D9.10 from Streptomyces coelicolor (98 aa), FASTA scores: opt: 298, E(): 4e-13, (53.7% identity in 95 aa overlap); O06492|GATC_BACSU from B. subtilis (96 aa), FASTA scores: opt: 222, E(): 3.7e-08,(43.15% identity in 95 aa overlap); Q9KF29|BH0665 from Bacillus halodurans (96 aa), FASTA scores: opt: 211, E(): 1.9e-07, (41.05% identity in 95 aa overlap); etc. For more information about function, see citation below. BELONGS TO THE GATC FAMILY. X2BMU2,P64206 No NC_002945.3 Mycobrowser_v2 CDS 3329160 3331235 . - 0 Mb3039c ligA dna ligase [nad dependent] liga (polydeoxyribonucleotide synthase [nad+]) Mb3039c, ligA, len: 691 aa. Equivalent to Rv3014c,len: 691 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 691 aa overlap). Probable ligA (alternate gene name: lig), DNA ligase NAD-dependent (EC 6.5.1.2), equivalent to O33102|DNLJ_MYCLE|LIGA|LIG|ML1705|MLCB637.10 DNA LIGASE from Mycobacterium leprae (694 aa), FASTA scores: opt: 3844, E(): 0, (84.7% identity in 687 aa overlap). Also highly similar to many prokaryotic and eukaryotic ligases e.g. Q9Z585|LIGA|SC8D9.06 from Streptomyces coelicolor (735 aa), FASTA scores: opt: 2002, E(): 4e-113, (59.4% identity in 714 aa overlap); P49421|DNLJ_RHOMR|LIGA|LIG from Rhodothermus marinus (712 aa), FASTA scores: opt: 1835, E(): 4.6e-103, (45.55% identity in 685 aa overlap); P15042|DNLJ_ECOLI|LIGA|LIG|DNAL|PDEC|LOP|B2411 from Escherichia coli strain K12 (671 aa), FASTA scores: opt: 1696, E(): 1.1e-94, (43.8% identity in 680 aa overlap); etc. BELONGS TO THE NAD-DEPENDENT DNA LIGASE FAMILY. X2BM51,P63974 No NC_002945.3 Mycobrowser_v2 CDS 3331266 3332279 . - 0 Mb3040c CONSERVED HYPOTHETICAL PROTEIN Mb3040c, -, len: 337 aa. Equivalent to Rv3015c,len: 337 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 337 aa overlap). Conserved hypothetical protein, equivalent to Q9CBR6|ML1706 HYPOTHETICAL PROTEIN from Mycobacterium leprae (337 aa),FASTA scores: opt: 1703, E(): 3.1e-92, (78.05% identity in 337 aa overlap); and (but longer 47 aa) O33101|MLCB637.09 HYPOTHETICAL 30.0 KDA PROTEIN from Mycobacterium leprae (290 aa), FASTA scores: opt: 1564, E(): 2.4e-78, (78.6% identity in 290 aa overlap). Also similar to Q9Z586|SC8D9.05 HYPOTHETICAL 35.0 KDA PROTEIN from Streptomyces coelicolor (331 aa), FASTA scores: opt: 774,E(): 4.7e-38, (43.4% identity in 334 aa overlap); and showing similarity with other proteins e.g. Q39586|METE_CHLRE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE from Chlamydomonas reinhardtii (814 aa),FASTA scores: opt: 162, E(): 0.048, (27.05% identity in 355 aa overlap). Q7TXG0 No conserved hypotheticals Rv3015c NC_002945.3 Mycobrowser_v2 CDS 3333105 3333467 . - 0 Mb3042c esxQ esat-6 like protein esxq (tb12.9) (esat-6 like protein 8) Mb3042c, esxQ, len: 120 aa. Equivalent to Rv3017c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). esxQ, putative ESAT-6 like protein 8, possibly secreted protein, very similar to AAK47433|MT3104 PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis strain CDC1551 (96 aa),FASTA scores: opt: 315, E(): 1.2e-14, (65.7% identity in 70 aa overlap); Rv3019c|O53266|MTV012.33c PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 315, E(): 1.2e-14, (65.7% identity in 70 aa overlap) and Rv0288|O53693|CFP7|MT0301|MTV035.16 10 KDA ANTIGEN CFP7 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7) (CFP-7) from Mycobacterium tuberculosis (95 aa), FASTA scores: opt: 303, E(): 7.4e-14, (66.2% identity in 68 aa overlap). BELONGS TO THE ESAT6 FAMILY. X2BMU7 No NC_002945.3 Mycobrowser_v2 misc_RNA 3424360 3424966 . - 0 ssr ssr 10Sa RNA ssr, len: 607 nt. Equivalent to ssr, len: 607 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 607 nt overlap). Match to EM_BA:MT10SARNA X60301 M.tuberculosis gene for 10Sa RNA. No NC_002945.3 Mycobrowser_v2 CDS 3333554 3334867 . - 0 Mb3043c PPE46 ppe family protein ppe46 Mb3043c, PPE46, len: 437 aa. Equivalent to Rv3018c,len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 431 aa overlap). Member of PPE family but lacks Gly, Ala rich repeats at C-terminal domain,closest to MTCY261.19. Also very similar to following ORF MTV012.35c. Nearly identical in parts to Mycobacterium tuberculosis protein erroneously described as DIHYDROFOLATE REDUCTASE (X59271|MTFOLA_1) P31500|DYR_MYCTU (214 aa), FASTA scores: opt: 972, E(): 4.4e-42, (80.0% identity in 195 aa overlap); and Z97559|MTCY261_19 from M. tuberculosis cosmid (473 aa), FASTA scores: opt: 806, E(): 0; (38.8% identity in 479 aa overlap); and O53268|MTV012.35c from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 1714, E(): 3.3e-79, (78.3% identity in 355 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 56 bp deletion leads to a product slightly different at the Nh2-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa). Q7TXF8 No NC_002945.3 Mycobrowser_v2 CDS 3335270 3335560 . - 0 Mb3045c esxR secreted esat-6 like protein esxr (tb10.3) (esat-6 like protein 9) Mb3045c, esxR, len: 96 aa. Equivalent to Rv3019c,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). esxR, putative secreted ESAT-6 like protein 9 (see citations below), most similar to O53693|AAK44525|Rv0288|CFP7|MT0301|MTV035.16 10 KDA ANTIGEN CFP7 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7) (CFP-7) from Mycobacterium tuberculosis (95 aa), FASTA scores: opt: 566, E(): 5.1e-31, (84.3% identity in 95 aa overlap). Also similar to Q9CD33|ML2531 POSSIBLE CELL SURFACE PROTEIN from Mycobacterium leprae (96 aa), FASTA scores: opt: 472, E(): 8.3e-25, (66.6% identity in 96 aa overlap); O53264|Rv3017c|MTV012.31c PUTATIVE SECRETED ANTIGEN from Mycobacterium tuberculosis (120 aa), FASTA scores: opt: 321, E(): 9.6e-15, (67.15% identity in 70 aa overlap); Q57165|AAK48357|O84901|X79562|ESAT6|Rv3875|MT3989|MTV027.1 0esat6 gene from Mycobacterium tuberculosis strain Erdman (94 aa), FASTA scores: opt: 131, E(): 0.028, (26.1% identity in 88 aa overlap). BELONGS TO THE ESAT6 FAMILY. TBparse score is 0.906. X2BMG4 No NC_002945.3 Mycobrowser_v2 CDS 3335595 3335888 . - 0 Mb3046c esxS esat-6 like protein esxs Mb3046c, esxS, len: 97 aa. Equivalent to Rv3020c,len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Member of Mycobacterium tuberculosis PE family (see first citation below), similar to others e.g. AAK44524|MT0300 PE FAMILY PROTEIN from M. tuberculosis strain CDC1551 (97 aa), FASTA scores: opt: 564, E(): 5.9e-30, (91.75% identity in 97 aa overlap). Has potential helix-turn-helix motif at positions 14-35. TBparse score is 0.912. SEEMS TO BELONG TO THE ESAT6 FAMILY (see second citation below). Q7TXF7 No NC_002945.3 Mycobrowser_v2 CDS 3335935 3337242 . - 0 Mb3047c PPE47 ppe family protein ppe47 Mb3047c, PPE47, len: 435 aa. Equivalent to Rv3022c (PPE48) and Rv3021c (PPE47), len: 81 aa and 358 aa, from Mycobacterium tuberculosis strain H37Rv, (98.8% identity in 81 aa overlap and 98.6% identity in 354 aa overlap). Member of Mycobacterium tuberculosis PPE family. Should be continuation of upstream ORF MTV012.36c but is frameshifted due to missing base at 36448 in v012. Sequence has been checked but no error apparent. Very similar to neighbouring ORF O53265|MTV012.32c|Rv3018c from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 1714, E(): 6.6e-770, (78.3% identity in 355 aa overlap) and AAK47430|MT3101 (strongly in the N-terminal part) (310 aa), FASTA scores: opt: 897, E(): 4.5e-37, (66.95% identity in 227 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Q7TXF6 No PE/PPE Rv3022c NC_002945.3 Mycobrowser_v2 CDS 3337935 3339182 . - 0 Mb3049c PROBABLE TRANSPOSASE Mb3049c, -, len: 415 aa. Equivalent to Rv3023c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 415 aa overlap). Probable IS1081 transposase. Contains PS01007 Transposases, Mutator family, signature. Similars to P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c and Rv2512c|MTCY07A7.18c TRANSPOSASES FOR INSERTION SEQUENCE ELEMENT IS1081 (415 aa), FASTA scores: opt: 2675, E(): 1.8e-162, (100.0% identity in 415 aa overlap). TBparse score is 0.894. BELONGS TO THE MUTATOR FAMILY OF TRANSPOSASE. X2BGW7,P60231 No insertion seqs and phages Rv3023c NC_002945.3 Mycobrowser_v2 CDS 3339345 3340448 . - 0 Mb3050c trmU PROBABLE tRNA (5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE TRMU Mb3050c, trmU, len: 367 aa. Equivalent to Rv3024c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 367 aa overlap). Probable trmU, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61), equivalent to O33099|TRMU_MYCLE|ML1707|MLCB637.07 PROBABLE tRNA (5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE from Mycobacterium leprae (358 aa), FASTA scores: opt: 2033, E(): 5.5e-116, (85.45% identity in 357 aa overlap). Also highly similar to others e.g. O86583|TRMU_STRCO|SC2A11.22 from Streptomyces coelicolor (376 aa), FASTA scores: opt: 1336, E(): 1e-73, (56.9% identity in 369 aa overlap); BAB49856|MLR2824 from Rhizobium loti (378 aa), FASTA scores: opt: 826, E(): 8.3e-43, (42.35% identity in 359 aa overlap); Q9ZDM1|TRMU_RICPR|RP306 from Rickettsia prowazekii (358 aa), FASTA scores: opt: 800, E(): 3e-41, (40.1% identity in 359 aa overlap); etc. BELONGS TO THE TRMU FAMILY. X2BMG7,P66977 No NC_002945.3 Mycobrowser_v2 CDS 3345661 3346485 . + 0 Mb3056 conserved protein Mb3056, -, len: 274 aa. Equivalent to Rv3030, len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Conserved hypothetical protein, equivalent to O33094|MLCB637.02c|ML1713 hypothetical 30.8 KDa protein from Mycobacterium leprae (280 aa), FASTA scores: opt: 1388, E(): 5.5e-83, (78.2% identity in 280 aa overlap). N-terminus has similarity to hypothetical proteins from a number of organisms and to Q54303|EMBL:X86780|RAPM methyltransferase from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 191, E(): 3.6e-05, (35.65% identity in 101 aa overlap). Q7TXF0 No conserved hypotheticals Rv3030 NC_002945.3 Mycobrowser_v2 CDS 3340445 3341626 . - 0 Mb3051c iscS cysteine desulfurase iscs (nifs protein homolog) (nitrogenase metalloclusters biosynthesis protein nifs) Mb3051c, iscS, len: 393 aa. Equivalent to Rv3025c,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Probable iscS (alternate gene name: nifS), cysteine desulfurase (NifS-like protein) (EC 4.4.1.-), equivalent to MLCB637.06|O33098 NIFS-LIKE PROTEIN from Mycobacterium leprae (396 aa), FASTA scores: opt: 2186, E(): 2.7e-122,(84.9% identity in 391 aa overlap). Also highly similar to many e.g. O86581|SC2A11.20 PUTATIVE PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASE from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1568,E(): 1.1e-85, (61.7% identity in 389 aa overlap); P57795|ISCS|NIFS CYSTEINE DESULFURASE (NIFS PROTEIN HOMOLOG) from Methanosarcina thermophila (404 aa), FASTA scores: opt: 1059, E(): 1.6e-55, (46.2% identity in 381 aa overlap); O54055|ISCS_RUMFL|ISCS|NIFS CYSTEINE DESULFURASE from Ruminococcus flavefaciens (396 aa), FASTA scores: opt: 973, E(): 2e-50, (43.3% identity in 381 aa overlap); P57794|NIFS_ACEDI CYSTEINE DESULFURASE from Acetobacter diazotrophicus (400 aa), FASTA scores: opt: 958, E(): 1.6e-49, (41.1% identity in 392 aa overlap); etc. Also similar to Rv1464|MTV007.11 from Mycobacterium tuberculosis. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, NIFS/ISCS SUBFAMILY. COFACTOR: PYRIDOXAL PHOSPHATE (BY SIMILARITY). Q7TXF4 No NC_002945.3 Mycobrowser_v2 CDS 3358493 3359722 . - 0 Mb3068c serB2 PROBABLE PHOSPHOSERINE PHOSPHATASE SERB2 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE) Mb3068c, serB2, len: 409 aa. Equivalent to Rv3042c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 409 aa overlap). Probable serB2,Phosphoserine phosphatase (EC 3.1.3.3), equivalent to Q9CBQ6|ML1727 PUTATIVE PHOSPHOSERINE PHOSPHATASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 2173,E(): 1.3e-117, (86.3% identity in 408 aa overlap). Also similar to other e.g. Q9S281|SCI28.02 from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1209, E(): 3e-62,(51.75% identity in 400 aa overlap); Q9HUK|PA4960 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 704,E(): 3.1e-33, (40.95% identity in 393 aa overlap); O28142|SERB_ARCTU|AF2138 from Archaeoglobus fulgidus (344 aa), FASTA scores: opt: 671, E(): 2e-31, (37.25% identity in 325 aa overlap); and P06862|SERB_ECOLI (322 aa), FASTA scores: opt: 628, E(): 5.7e-29, (46.8% identity in 235 aa overlap). BELONGS TO THE SERB FAMILY. Q7TXD8 No NC_002945.3 Mycobrowser_v2 CDS 3341723 3342637 . - 0 Mb3052c CONSERVED HYPOTHETICAL PROTEIN Mb3052c, -, len: 304 aa. Equivalent to Rv3026c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Conserved hypothetical protein, similar to Q9RCZ0|SCM10.08C PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (275 aa),FASTA scores: opt: 393, E(): 2.2e-17, (41.4% identity in 299 aa overlap). Similar in part to other hypothetical proteins and acyltransferases e.g. BAB51968|MLR5533 from Rhizobium loti (266 aa), FASTA scores: opt: 280, E(): 2.4e-10, (29.45% identity in 258 aa overlap); Q9KIH9 PUTATIVE ACYLTRANSFERASE (PUTATIVE ACYLTRANSFERASE TRANSMEMBRANE PROTEIN) (EC 2.3.1.) from Rhizobium meliloti (Sinorhizobium meliloti) (292 aa), FASTA scores: opt: 252,E(): 1.4e-08, (30.5% identity in 210 aa overlap); O69114|PLSC PUTATIVE 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE from Burkholderia pseudomallei (Pseudomonas pseudomallei) (289 aa), FASTA scores: opt: 216, E(): 2.4e-06, (30.85% identity in 269 aa overlap); etc. So may be a member of acyltransferase family protein. Q7TXF3 No conserved hypotheticals Rv3026c NC_002945.3 Mycobrowser_v2 CDS 3441861 3442331 . + 0 Mb3145 HYPOTHETICAL PROTEIN Mb3145, -, len: 155 aa. Equivalent to Rv3122, len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 155 aa overlap). Hypothetical unknown protein. Q7TX79 No conserved hypotheticals Rv3122 NC_002945.3 Mycobrowser_v2 CDS 3342634 3343374 . - 0 Mb3053c gcn5-related n-acetyltransferase Mb3053c, -, len: 246 aa. Equivalent to Rv3027c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Conserved hypothetical protein, similar, but shorter 30 aa in N-terminus, to others e.g. Q9RCY9|SCM10.09c from Streptomyces coelicolor (256 aa), FASTA scores: opt: 498,E(): 7.8e-24, (47.7% identity in 237 aa overlap); BAB50158|MLR3216 from Rhizobium loti (291 aa), FASTA scores: opt: 359, E(): 3.7e-15, (33.35% identity in 246 aa overlap); etc. Equivalent to AAK47441 from Mycobacterium tuberculosis strain CDC1551 (281 aa) but shorter 35 aa. Q7TXF2 No intermediary metabolism and respiration Rv3027c NC_002945.3 Mycobrowser_v2 CDS 3343635 3344591 . - 0 Mb3054c fixB PROBABLE ELECTRON TRANSFER FLAVOPROTEIN (ALPHA-SUBUNIT) FIXB (ALPHA-ETF) (ELECTRON TRANSFER FLAVOPROTEIN LARGE SUBUNIT) (ETFLS) Mb3054c, fixB, len: 318 aa. Equivalent to Rv3028c,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 318 aa overlap). Probable fixB (alternate gene name: etfA), electron transfer flavoprotein (alpha subunit) for various dehydrogenases. Equivalent to O33096|ETFA_MYCLE|FIXB|ML1711|MLCB637.04 ELECTRON TRANSFER FLAVOPROTEIN from Mycobacterium leprae (318 aa), FASTA scores: opt: 1788, E(): 1.1e-87, (89.3% identity in 318 aa overlap). Also highly similar to many e.g. Q9K418|SCG22.27c from Streptomyces coelicolor (320 aa), FASTA scores: opt: 1161, E(): 1.6e-54, (59.45% identity in 323 aa overlap); AAK08137|etfa from Rhodobacter sphaeroides (308 aa), FASTA scores: opt: 792,E(): 5.1e-35, (45.95% identity in 309 aa overlap); P38974|ETFA_PARDE ELECTRON TRANSFER FLAVOPROTEIN from Paracoccus denitrificans (307 aa), FASTA scores: opt: 789,E(): 7.4e-35, (45.95% identity in 309 aa overlap); etc. BELONGS TO THE ETF ALPHA-SUBUNIT / FIXB FAMILY. Q7TXF1 No NC_002945.3 Mycobrowser_v2 CDS 3344630 3345430 . - 0 Mb3055c fixA PROBABLE ELECTRON TRANSFER FLAVOPROTEIN (BETA-SUBUNIT) FIXA (BETA-ETF) (ELECTRON TRANSFER FLAVOPROTEIN SMALL SUBUNIT) (ETFSS) Mb3055c, fixA, len: 266 aa. Equivalent to Rv3029c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable fixA (alternate gene name: etfB), electron transfer flavoprotein (beta-subunit). Equivalent of O33095|ETFB_MYCLE|FixA|MLCB637.03 ELECTRON TRANSFER FLAVOPROTEIN from Mycobacterium leprae (266 aa), FASTA scores: opt: 1603, E(): 7.6e-87, (95.1% identity in 266 aa overlap). Also highly similar to others e.g. Q9K417|SCG22.28c from Streptomyces coelicolor (262 aa),FASTA scores: opt: 860, E(): 2.3e-43, (52.4% identity in 263 aa overlap); O85691|ETFB_MEGEL from Megasphaera elsdenii (270 aa), FASTA scores: opt: 548, E(): 4.2e-25,(35.15% identity in 273 aa overlap); etc. Also highly similar in particular to Q9KHD0|NONH FLAVOPROTEIN REDUCTASE from Streptomyces griseus subsp. griseus (this one is required for macrotetrolide biosynthesis in Streptomyces griseus) (261 aa), FASTA scores: opt: 867,E(): 8.8e-44, (54.0% identity in 263 aa overlap). BELONGS TO THE ETF BETA-SUBUNIT / FIXA FAMILY. X2BMG9,P64098 No NC_002945.3 Mycobrowser_v2 CDS 3722262 3722522 . - 0 Mb3388c CONSERVED HYPOTHETICAL PROTEIN Mb3388c, -, len: 86 aa. Equivalent to Rv3353c, len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Hypothetical protein,showing some similarity to Q9X5Q4|MITR MITR PROTEIN from Streptomyces lavendulae (514 aa), FASTA scores: opt: 134,E(): 0.09, (29.5% identity in 78 aa overlap); and weak to Q49720|B1549_C3_218 from Mycobacterium leprae (222 aa),FASTA scores: opt: 99, E(): 8.8, (32.9% identity in 76 aa overlap). But highly similar to N-terminal part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from M. tuberculosis (479 aa), FASTA scores: opt: 305, E(): 4.9e-13, (52.9% identity in 87 aa overlap); and some similarity can be found with Rv3352c and Rv3351c. All show similarity to a family of oxidoreductases in M. tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found. Start changed since original submission. Q7TWN3 No conserved hypotheticals Rv3353c NC_002945.3 Mycobrowser_v2 CDS 3387975 3388385 . + 0 Mb3094 CONSERVED HYPOTHETICAL PROTEIN Mb3094, -, len: 136 aa. Equivalent to Rv3067, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Conserved hypothetical protein, weakly similar to other mycobacterium proteins e.g. O53953|Rv1804c|MTV049.26c (108 aa), FASTA scores: opt: 183, E(): 0.00053, (36.6% identity in 82 aa overlap); O07222|Rv1810|MTCY16F9.04c (118 aa),FASTA scores: opt: 149, E(): 0.05, (30.95% identity in 84 aa overlap). Has hydrophobic stretch at N-terminus. Start chosen on basis of codon usage but upstream ATG also possible. Q7TXB9 No conserved hypotheticals Rv3067 NC_002945.3 Mycobrowser_v2 CDS 3346482 3348062 . + 0 Mb3057 conserved protein Mb3057, -, len: 526 aa. Equivalent to Rv3031, len: 526 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 526 aa overlap). Conserved hypothetical protein, equivalent to Q9CBR4|ML1714 HYPOTHETICAL PROTEIN from Mycobacterium leprae (522 aa),FASTA scores: opt: 3167, E(): 4.4e-190, (86.15% identity in 526 aa overlap); and highly similar to truncated O33093|MLCB637.01c HYPOTHETICAL 37.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (338 aa), FASTA scores: opt: 2041, E(): 5.7e-120, (84.8% identity in 342 aa overlap). Also some similarity to hypothetical proteins Q9V0M7|PAB1857 from Pyrococcus abyssi (602 aa), FASTA scores: opt: 477, E(): 3.5e-22, (31.2% identity in 556 aa overlap); and Synechocystis P74630|D90916|SLL0735 from Synechocystis sp. strain PCC 6803 (529 aa), FASTA scores: opt: 282, E(): 4.7e-10, (28.6% identity in 560 aa overlap). Q7TXE9 No conserved hypotheticals Rv3031 NC_002945.3 Mycobrowser_v2 CDS 3348094 3349338 . + 0 Mb3058 alpha (1->4) glucosyltransferase Mb3058, -, len: 414 aa. Equivalent to Rv3032, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Possible transferase (EC 2.-.-.-), equivalent to Q9CBR3|ML1715 PUTATIVE TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2456, E(): 7.3e-145, (87.9% identity in 414 aa overlap). Also similar to hypothetical proteins and various transferases e.g. P73369|SLL1971 HYPOTHETICAL 46.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (404 aa), FASTA scores: opt: 584, E(): 7.3e-29, (34.5% identity in 400 aa overlap); Q9Z5B7|SC2G5.06 PUTATIVE TRANSFERASE from Streptomyces coelicolor (406 aa), FASTA scores: opt: 509, E(): 3.3e-24, (35.9% identity in 413 aa overlap); Q9UZA1|PAB0827 GALACTOSYLTRANSFERASE (LPS BIOSYNTHESIS RFBU RELATED PROTEIN) from Pyrococcus abyssi (371 aa),FASTA scores: opt: 381, E(): 2.6e-16, (26.75% identity in 404 aa overlap); etc. Q7TXE8 No intermediary metabolism and respiration Rv3032 NC_002945.3 Mycobrowser_v2 CDS 3349372 3349761 . + 0 Mb3058A Conserved protein Mb3058A, len: 129 aa. Equivalent to Rv3032A len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BM67 No conserved hypotheticals Rv3032A NC_002945.3 Mycobrowser_v2 CDS 3349940 3350488 . + 0 Mb3059 unknown protein Mb3059, -, len: 182 aa. Equivalent to Rv3033, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Hypothetical unknown protein. Q7TXE7 No conserved hypotheticals Rv3033 NC_002945.3 Mycobrowser_v2 CDS 3350579 3351481 . - 0 Mb3060c POSSIBLE TRANSFERASE Mb3060c, -, len: 300 aa. Equivalent to Rv3034c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Possible transferase (2.-.-.-), equivalent to AAK47449|MT3119 Hexapeptide transferase family protein from Mycobacterium tuberculosis strain CDC1551 but N-terminus shorter 39 residues (262 aa), FASTA scores: opt: 1773, E(): 4.7e-105, (100.0% identity in 262 aa overlap). Similar to Q9CBR1|ML1719 from Mycobacterium leprae but also shorter in N-terminus (245 aa), FASTA scores: opt: 1549, E(): 6.6e-91, (90.6% identity in 244 aa overlap). Some weakly similarity with other transferases (C-terminal part shows some similarity to acetyltransferase from Methanococcus jannaschii (214 aa)). Alternative start possible at 3395077 but codon usage not as good. Q7TXE6 No intermediary metabolism and respiration Rv3034c NC_002945.3 Mycobrowser_v2 CDS 3354985 3355968 . - 0 Mb3064c conserved protein Mb3064c, -, len: 327 aa. Equivalent to Rv3038c,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 327 aa overlap). Conserved hypothetical protein, equivalent to Q9CBQ9|ML1723 HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa),FASTA scores: opt: 1843, E(): 6.1e-108, (80.75% identity in 327 aa overlap). Weak similarity with e.g. Q9KZI3|SCG8A.16 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (199 aa), FASTA scores: opt: 227,E(): 3.9e-07, (31.95% identity in 191 aa overlap) and O52570 METHYLTRANSFERASE from Amycolatopsis mediterranei (272 aa), FASTA scores: opt: 228, E(): 4.3e-07, (31.7% identity in 164 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature but shows no similarity to known LysR family members. Q7TXE2 No conserved hypotheticals Rv3038c NC_002945.3 Mycobrowser_v2 CDS 3372627 3373241 . + 0 Mb3081 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3081, -, len: 204 aa. Equivalent to Rv3055, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible transcriptional regulatory protein, similar to Q9RD23|SCM1.20c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (234 aa), FASTA scores: opt: 471, E(): 4.6e-23, (44.9% identity in 187 aa overlap); and with low similarity to other e.g. Q9ADK8|2SCK31.12 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (198 aa), FASTA scores: opt: 208, 2.5e-06, (32.9% identity in 155 aa overlap); Q9ADD9|SCBAC20F6.11c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (199 aa),FASTA scores: opt: 182, E(): 0.00012, (31.0% identity in 184 aa overlap). Contains potential helix-turn-helix motif from aa 48 to 69 (+3.42 SD). SO MAY BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TXC9 No regulatory proteins Rv3055 NC_002945.3 Mycobrowser_v2 CDS 3355979 3356743 . - 0 Mb3065c echA17 PROBABLE ENOYL-COA HYDRATASE ECHA17 (CROTONASE) (UNSATURED ACYL-CoA HYDRATASE) (ENOYL HYDRASE) Mb3065c, echA17, len: 254 aa. Equivalent to Rv3039c, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 254 aa overlap). Probable echA17, Enoyl-CoA Hydratase/Isomerase Superfamily member (crotonase) (EC 4.2.1.17). Similar to many e.g. Q9L1E6|SC3D11.16 PUTATIVE ENOYL-COA HYDRATASE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 625,E(): 1.5e-30, (45.55% identity in 224 aa overlap); O07137||ECH8_MYCLE|ML2402|MLCB1306.05c PROBABLE ENOYL-COA HYDRATASE ECHA8 from Mycobacterium leprae (257 aa), FASTA scores: opt: 448, E(): 6.4e-20, (35.3% identity in 235 aa overlap), P97087|CRT CROTONASE / ENOYL-COA HYDRATASE from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 420,E(): 3.1e-18, (31.2% identity in 234 aa overlap). Also similar to Mycobacterium tuberculosis AAK45356|O53418|Rv1070c|ECHA8|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE ECHA8 (257 aa), FASTA scores: opt: 450, E(): 4.9e-20, (36.4% identity in 226 aa overlap). BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. X2BMF2,Q7TXE1 No lipid metabolism Rv3039c NC_002945.3 Mycobrowser_v2 CDS 3356752 3357618 . - 0 Mb3066c conserved protein Mb3066c, -, len: 288 aa. Equivalent to Rv3040c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap). Conserved hypothetical protein, highly similar to Q9XA40|SCH17.07c hypothetical protein from Streptomyces coelicolor (312 aa), FASTA scores: opt: 648, E(): 5.2e-34, (50.0% identity in 260 aa overlap). Also similar to Q9F7R7 PREDICTED MUTT SUPERFAMILY HYDROLASE from uncultured proteobacterium EBAC31A08 (264 aa), FASTA scores: opt: 295, E(): 1.3e-11,(27.2% identity in 257 aa overlap); AAK24293|CC2322 hypothetical protein from Caulobacter crescentus (254 aa),BLAST scores: 185 (32% identity) AND 131 (37% identity),etc. Q7TXE0 No conserved hypotheticals Rv3040c NC_002945.3 Mycobrowser_v2 CDS 3357615 3358478 . - 0 Mb3067c PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER Mb3067c, -, len: 287 aa. Equivalent to Rv3041c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). Probable conserved ATP-binding protein ABC transporter (see citation below),equivalent to Q9CBQ7|ML1726 PUTATIVE ABC TRANSPORTER PROTEIN ATP-BINDING PROTEIN from Mycobacterium leprae (305 aa), FASTA scores: opt: 1576, E(): 8.6e-85, (83.4% identity in 289 aa overlap). Also similar to other putative ATP-binding proteins ABC transporters e.g. Q9X9Z4|SCI5.06C from Streptomyces coelicolor (265 aa),FASTA scores: opt: 893, E(): 4.8e-45, (53.3% identity in 257 aa overlap); Q9L156|SC5C11.16c from Streptomyces coelicolor (279 aa), FASTA scores: opt: 680, E(): 1.3e-32,(45.4% identity in 271 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TXD9 No cell wall and cell processes Rv3041c NC_002945.3 Mycobrowser_v2 CDS 3373251 3374291 . + 0 Mb3082 dinP possible dna-damage-inducible protein p dinp (dna polymerase v) (pol iv 2) (dna nucleotidyltransferase (dna-directed)) Mb3082, dinP, len: 346 aa. Equivalent to Rv3056,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Possible dinP,DNA-damage-inducible protein, similar to other e.g. AAK45855|MT1589 from Mycobacterium tuberculosis strain CDC1551 (485 aa), FASTA scores: opt: 620, E(): 6.1e-32,(37.2% identity in 344 aa overlap); BAB49140|MLR1877 from Rhizobium loti (Mesorhizobium loti) (415 aa), FASTA scores: opt: 533, E(): 1.8e-26, (34.35% identity in 358 aa overlap); and BAB54888|MLL9709 from Rhizobium loti (Mesorhizobium loti) (361 aa), FASTA scores: opt: 532,E(): 1.8e-26, (35.35% identity in 348 aa overlap). Extensive similarity to proteins induced by DNA damage such as dinP, mucB, umuC. X2BN83,P63988 No information pathways Rv3056 NC_002945.3 Mycobrowser_v2 CDS 3359760 3361481 . - 0 Mb3069c ctaD PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) Mb3069c, ctaD, len: 573 aa. Equivalent to Rv3043c,len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 573 aa overlap). Probable ctaD,integral membrane cytochrome C oxidase polypeptide I (EC 1.9.3.1), equivalent to Q9CBQ5|ML1728 from Mycobacterium leprae (574 aa), FASTA scores: opt: 3738, E(): 3.8e-216,(95.4% identity in 566 aa overlap). Also similar to other CYTOCHROME C OXIDASES POLYPEPTIDE I e.g. Q9AEL9|CTAD from Corynebacterium glutamicum (Brevibacterium flavum) (584 aa), FASTA scores: opt: 3065, E(): 6.8e-176, (72.65% identity in 567 aa overlap); Q9X813|SC6G10.28c from Streptomyces coelicolor (578 aa), FASTA scores: opt: 2888,E(): 2.6e-165, (71.7% identity in 544 aa overlap); Q9K451|CTAD from Streptomyces coelicolor (573 aa), FASTA scores: opt: 2757, E(): 1.8e-157, (70.2% identity in 537 aa overlap). Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature. BELONGS TO THE HEME-COPPER RESPIRATORY OXIDASE FAMILY. X2BMH9,P63853 No NC_002945.3 Mycobrowser_v2 CDS 3361696 3362775 . + 0 Mb3070 fecB PROBABLE FEIII-DICITRATE-BINDING PERIPLASMIC LIPOPROTEIN FECB Mb3070, fecB, len: 359 aa. Equivalent to Rv3044,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable fecB, FeIII dicitrate-binding periplasmic lipoprotein (see citation below), equivalent to Q9CBQ4|FECB|ML1729 PUTATIVE FEIII-DICITRATE TRANSPORTER LIPOPROTEIN from Mycobacterium leprae (364 aa), FASTA scores: opt: 1816, E(): 1.1e-96,(75.65% identity in 357 aa overlap); and Q9LA57|FECB from M. avium (364 aa), FASTA scores: opt: 1769, E(): 5.1e-94. Similar to many periplasmic FeIII-dicitrate transporters e.g. P72593|FECB|SLR1319 from Synechocystis sp. strain PCC 6803 (315 aa), FASTA scores: opt: 459, E(): 3.6e-19,(31.35% identity in 303 aa overlap); and P72611|FECB|SLR1492 from Synechocystis sp. strain PCC 6803. N-terminus longer (approximatively 30 aa) to AAK47459 from Mycobacterium tuberculosis strain CDC1551 (327 aa). Has signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TXD7 No cell wall and cell processes Rv3044 NC_002945.3 Mycobrowser_v2 CDS 3436248 3436499 . + 0 Mb3139 moaD1 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D MOAD1 (MOLYBDOPTERIN CONVERTING FACTOR SMALL SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 1) Mb3139, moaD1, len: 83 aa. Equivalent to Rv3112,len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Probable moaD1,molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to others e.g. Q9HJF0|TA1019 from Thermoplasma acidophilum (85 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); BAB59710|TVG0556526 from Thermoplasma volcanium (90 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); P30748|MOAD_ECOLI|CHLA4|CHLM|B0784 from Escherichia coli strain K12 (81 aa), FASTA scores: opt: 116, E(): 0.11,(36.9% identity in 84 aa overlap); etc. N-terminus also highly similar to to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 333, E(): 2e-16, (65.05% identity in 83 aa overlap); and some similarity with Rv0868c|MTV043.61c|MOAD2 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D 2 (92 aa). Note that previously known as moaD. Q7TTR6 No intermediary metabolism and respiration Rv3112 NC_002945.3 Mycobrowser_v2 CDS 3395619 3396095 . + 0 Mb3103 CONSERVED HYPOTHETICAL PROTEIN Mb3103, -, len: 158 aa. Equivalent to Rv3076, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, weakly similar to Q9AK12|SC8D11.07 HYPOTHETICAL 17.0 KDA PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 110, E(): 1.5, (25.5% identity in 145 aa overlap). Q7TXB3 No conserved hypotheticals Rv3076 NC_002945.3 Mycobrowser_v2 CDS 3362845 3363885 . + 0 Mb3071 adhC PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC Mb3071, adhC, len: 346 aa. Equivalent to Rv3045,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Probable adhC,NADP-dependent alcohol dehydrogenase (EC 1.1.1.2),equivalent to Q9CBQ3|ADHA|ML1730 ALCOHOL DEHYDROGENASES from Mycobacterium leprae (362 aa), FASTA scores: opt: 1982, E(): 1.3e-111, (85.85% identity in 346 aa overlap); Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347 aa overlap); Q9EWF1|SCK13.33c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (346 aa), FASTA scores: opt: 1508,E(): 3.3e-83, (64.45% identity in 346 aa overlap); O06007|ADHA from Bacillus subtilis (349 aa), FASTA scores: opt: 1412, E(): 1.9e-77, (61.8% identity in 335 aa overlap); etc. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY. HIGH SIMILARITY WITH OTHER BACTERIAL ADH'S. X2BMX0,P0A4X1 No intermediary metabolism and respiration Rv3045 NC_002945.3 Mycobrowser_v2 CDS 3363874 3364248 . - 0 Mb3072c conserved protein Mb3072c, -, len: 124 aa. Equivalent to Rv3046c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Q50171|ML2258 U296W HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa),FASTA scores: opt: 194, E(): 7.6e-06, (35.9% identity in 103 aa overlap); and O06409|Rv0543c|MTCY25D10.22c from Mycobacterium tuberculosis (100 aa), FASTA scores: opt: 192, E(): 1e-05, (34.7% identity in 98 aa overlap). Q7TXD6 No conserved hypotheticals Rv3046c NC_002945.3 Mycobrowser_v2 CDS 3364582 3364866 . - 0 Mb3073c HYPOTHETICAL PROTEIN Mb3073c, -, len: 94 aa. Equivalent to Rv3047c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Hypothetical unknown protein. Q7TXD5 No conserved hypotheticals Rv3047c NC_002945.3 Mycobrowser_v2 CDS 3364964 3365938 . - 0 Mb3074c nrdF2 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF2 (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) Mb3074c, nrdF2, len: 324 aa. Equivalent to Rv3048c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). nrdF2,ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1) (see citation below), equivalent to Q9CBQ2|RIR2_MYCL|NRDF|ML1731 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN from Mycobacterium leprae (325 aa),FASTA scores: opt: 2009, E(): 1.3e-123, (93.5% identity in 324 aa overlap). Also similar to other ribonucleoside-diphosphate reductases e.g. Q9XD62|NRDF from Corynebacterium glutamicum (Brevibacterium flavum) (334 aa), FASTA scores: opt: 1648, E(): 4.2e-100, (78.35% identity in 314 aa overlap); O69274|NRDF from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (329 aa), FASTA scores: opt: 1626, E(): 1.1e-98, (75.3% identity in 320 aa overlap); P37146|NRDF|B2676 from Escherichia coli (319 aa), FASTA scores: opt: 1569, E(): 5.7e-95, (71.3% identity in 317 aa overlap). Contains PS00368 Ribonucleotide reductase small subunit signature. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. COFACTOR: BINDS 2 IRON IONS (BY SIMILARITY). Note that previously known as nrdG. Q7TXD4 No NC_002945.3 Mycobrowser_v2 CDS 3366069 3367643 . - 0 Mb3075c PROBABLE MONOOXYGENASE Mb3075c, -, len: 524 aa. Equivalent to Rv3049c,len: 524 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 524 aa overlap). Probable monooxygenase (EC 1.-.-.-), similar to several monooxygenases e.g. Q9I3H5|PA1538 PROBABLE FLAVIN-CONTAINING MONOOXYGENASE from Pseudomonas aeruginosa (527 aa), FASTA scores: opt: 1577, E(): 3.9e-90, (47.3% identity in 501 aa overlap); Q9RKB5|SCE87.23c MONOOXYGENASE from Streptomyces coelicolor (519 aa), FASTA scores: opt: 1522, E(): 9.8e-87, (47.4% identity in 485 aa overlap); Q9I218|PA2097 PROBABLE FLAVIN-BINDING MONOOXYGENASE from Pseudomonas aeruginosa (491 aa), FASTA scores: opt: 1366, E(): 4.2e-77, (43.75% identity in 489 aa overlap); etc. Also similar to Q10532|Rv0892|Y892_MYCTU|MT0916|MTCY31.20 PROBABLE MONOOXYGENASE (EC 1.14.13.-) from Mycobacterium tuberculosis strain H37Rv (495 aa), FASTA scores: opt: 1147, E(): 1.5e-63, (38.0% identity in 479 aa overlap). Q7TXD3 No intermediary metabolism and respiration Rv3049c NC_002945.3 Mycobrowser_v2 CDS 3367777 3368517 . - 0 Mb3076c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY) Mb3076c, -, len: 246 aa. Equivalent to Rv3050c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Probable transcriptional regulatory protein tetR-family, equivalent but shorter to Q9CBQ1|ML1733 from Mycobacterium leprae (275 aa), FASTA scores: opt: 1381,(E): 2.7e-79, (86.25% identity in 240 aa overlap); AAK44712|MT0489 from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 328,(E): 1.8e-13, (30.75% identity in 234 aa overlap); etc. Also some similarity to O53757|Rv0472c|MTV038.16c. Alternative starts possible at 68052 or 67923. Has potential helix-turn-helix motif at positons 51-72. Q7TXD2 No regulatory proteins Rv3050c NC_002945.3 Mycobrowser_v2 CDS 3368645 3370726 . - 0 Mb3077c nrdE ribonucleoside-diphosphate reductase (alpha chain) nrde (ribonucleotide reductase small subunit) (r1f protein) Mb3077c, nrdE, len: 693 aa. Equivalent to Rv3051c,len: 693 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 693 aa overlap). nrdE,ribonucleotide-diphosphate reductase, alpha chain (EC 1.17.4.1) (see citations below), equivalent to Q9CBQ0|NRDE|ML1734 from Mycobacterium leprae (693 aa),FASTA scores: opt: 4259,E(): 0, (93.2% identity in 693 aa overlap). Similar to other Ribonucleoside-diphosphate reductases e.g. Q9XD63|NRDE from Corynebacterium glutamicum (Brevibacterium flavum) (707 aa), FASTA scores: opt: 3683,E(): 0, (79.35% identity in 693 aa overlap); O69273|NRDE from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (720 aa), FASTA scores: opt: 3555, E(): 1.7e-214, (76.1% identity in 694 aa overlap); P39452|NRDE|B2675 from Escherichia coli (713 aa), FASTA scores: opt: 3430, E(): 1.1e-206, (73.6% identity in 693 aa overlap); etc. Equivalent to AAK47468|MT3137 from Mycobacterium tuberculosis strain CDC1551 (725 aa) but shorter in N-terminus. Contains PS00089 Ribonucleotide reductase large subunit signature. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE LARGE CHAIN FAMILY. X2BN79,P0A5W9 No NC_002945.3 Mycobrowser_v2 CDS 3370792 3371244 . - 0 Mb3078c nrdI PROBABLE NRDI PROTEIN Mb3078c, nrdI, len: 150 aa. Equivalent to Rv3052c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 150 aa overlap). Probable nrdI,equivalent to Q9CBP9|NRDI|ML1735 from Mycobacterium leprae (138 aa), FASTA scores: opt: 765, E(): 3.8e-44, (79.7% identity in 138 aa overlap), and similar to many NRDI PROTEINS e.g. Q47415|NRDI_ECOLI|B2674 from Escherichia coli (136 aa), FASTA scores: opt: 574, E(): 1.9e-31,(62.2% identity in 135 aa overlap). BELONGS TO THE NRDI FAMILY. X2BM85 No NC_002945.3 Mycobrowser_v2 CDS 3371279 3371518 . - 0 Mb3079c nrdH PROBABLE GLUTAREDOXIN ELECTRON TRANSPORT COMPONENT OF NRDEF (GLUTAREDOXIN-LIKE PROTEIN) NRDH Mb3079c, nrdH, len: 79 aa. Equivalent to Rv3053c,len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 79 aa overlap). Probable nrdH,glutaredoxin-like protein, equivalent to Q9CBP8|NRDH|ML1736 from Mycobacterium leprae (80 aa),FASTA scores: opt: 478, E(): 2.7e-27, (91.15% identity in 79 aa overlap), and similar to many glutaredoxin-like proteins e.g. Q9XD65|NRDH from Corynebacterium glutamicum (Brevibacterium flavum) (77 aa), FASTA scores: opt: 382,E(): 1.5e-20, (72.35% identity in 76 aa overlap); and Q56108|NRDH_SALTY from Salmonella typhimurium (81 aa),FASTA scores: opt: 243, E(): 9.9e-11, (45.85% identity in 72 aa overlap). BELONGS TO THE GLUTAREDOXIN FAMILY. Q7TXD1 No NC_002945.3 Mycobrowser_v2 CDS 3371981 3372535 . - 0 Mb3080c CONSERVED HYPOTHETICAL PROTEIN Mb3080c, -, len: 184 aa. Equivalent to Rv3054c,len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Conserved hypothetical protein, similar to Q9RD22|SCM1.21 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (187 aa),FASTA scores: opt: 651, E(): 1.5e-33, (56.8% identity in 175 aa overlap). Also shares similarity with other hypothetical proteins and Chromate reductases e.g. AAK56853|CHRR from Pseudomonas putida (186 aa), FASTA scores: opt: 339, E(): 3.3e-14, (38.75% identity in 160 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599) near C-terminus. Q7TXD0 No conserved hypotheticals Rv3054c NC_002945.3 Mycobrowser_v2 CDS 3374345 3375208 . - 0 Mb3083c PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE Mb3083c, -, len: 287 aa. Equivalent to Rv3057c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). Probable oxidoreductase, probably short-chain alcohol dehydrogenase/reductase (EC 1.1.-.-). Equivalent to Q9CBP7|ML1740 POSSIBLE SHORT CHAIN DEHYDROGENASES/REDUCTASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 1563, E(): 6e-89, (81.8% identity in 280 aa overlap). Also similar to many oxidoreductases e.g. Q9ZBX8|SCD78.21c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (585 aa), FASTA scores: opt: 541,E(): 6.7e-26, (37.25% identity in 263 aa overlap); AAK47506|MT3170 OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY from Mycobacterium tuberculosis strain CDC1551 (276 aa), FASTA scores: opt: 521, E(): 6.1e-25, (36.25% identity in 276 aa overlap); AAK45541|MT1283 OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY from Mycobacterium tuberculosis strain CDC1551 (276 aa), FASTA scores: opt: 471, E(): 7.2e-22, (32.4% identity in 281 aa overlap). Also similar to O50460|Rv1245c|MTV006.17C DEHYDROGENASE (276 aa). Contains short-chain alcohol dehydrogenase family signature (PS00061). MAY BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TXC8 No intermediary metabolism and respiration Rv3057c NC_002945.3 Mycobrowser_v2 CDS 3375272 3375922 . - 0 Mb3084c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3084c, -, len: 216 aa. Equivalent to Rv3058c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Possible transcriptional regulatory protein, tetR-family, showing reasonable similarity to others e.g. AAK48337|MT3970 from Mycobacterium tuberculosis strain CDC1551 (216 aa), FASTA scores: opt: 261, E(): 2.8e-10, (31.7% identity in 221 aa overlap); Q49962|ML1070|U1756B from Mycobacterium leprae (217 aa), FASTA scores: opt: 234, E(): 1.8e-08, (27.2% identity in 195 aa overlap); Q9CDD3|ML0064 from Mycobacterium leprae (214 aa), FASTA scores: opt: 199,E(): 3.6e-06, (25.65% identity in 195 aa overlap); O66121|CPRS from Streptomyces coelicolor (215 aa), FASTA scores: opt: 183, E(): 4.2e-05, (26.0% identity in 196 aa overlap). Equivalent to AAK47476|MT3144 from Mycobacterium tuberculosis strain CDC1551 (237 aa) but N-terminus shorter 21 residues. Start was predicted by TBparse but alternatives (ATG) are possible. COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TXC7 No regulatory proteins Rv3058c NC_002945.3 Mycobrowser_v2 CDS 3376038 3377516 . + 0 Mb3085 cyp136 PROBABLE CYTOCHROME P450 136 CYP136 Mb3085, cyp136, len: 492 aa. Equivalent to Rv3059,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Probable cyp136,cytochrome P450 136 (EC 1.14.-.-), similar to other cytochrome P450-dependent oxidases e.g. Q59990|CYP120|CYP|SLR0574 PUTATIVE CYTOCHROME P450 120 from Synechocystis sp. strain PCC 6803 (444 aa), FASTA scores: opt: 579, E(): 1.5e-29, (27.3% identity in 443 aa overlap); Q64654|CYP51|CP51_RAT CYTOCHROME P450 51 (EC 1.14.14.-) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Rattus norvegicus (Rat) (503 aa), FASTA scores: opt: 549, E(): 1.4e-27, (26.2% identity in 458 aa overlap); Q9JIY3|CYP51 LANOSTEROL 14-ALPHA-DEMETHYLASE from Mus musculus (Mouse) (486 aa), FASTA scores: opt: 546, E(): 2.1e-27, (25.75% identity in 458 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. Q7TXC6 No NC_002945.3 Mycobrowser_v2 CDS 3382131 3383654 . + 0 Mb3089 ligB probable atp-dependent dna ligase ligb (polydeoxyribonucleotide synthase [atp]) (polynucleotide ligase [atp]) (sealase) (dna repair protein) (dna joinase) Mb3089, ligB, len: 507 aa. Equivalent to Rv3062,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 507 aa overlap). Probable ligB, DNA ligase ATP-dependent (EC 6.5.1.1), highly similar to numerous archaebacterial and eukaryotic polynucleotide DNA ligases, e.g. Q9FCB1|DNLI_STRCO|LIG|2SCG58.02 from Streptomyces coelicolor (512 aa), FASTA scores: opt: 1677,E(): 2.5e-90, (55.65% identity in 512 aa overlap); Q9HR35|DNLI_HALN1|LIG|VNG0881G from Halobacterium sp. strain NRC-1 (561 aa), FASTA scores: opt: 985, E(): 5.6e-50, (42.25% identity in 440 aa overlap); Q9V185|DNLI_PYRAB|LIG|PAB2002 from Pyrococcus abyssi (559 aa), FASTA scores: opt: 978, E(): 1.4e-49, (39.05% identity in 443 aa overlap); etc. Also similar to Rv3731|MTV025.079|LIGC POSSIBLE DNA LIGASE from M. tuberculosis (358 aa). Similarity at N-terminus is poor so first start codon was taken. Contains (PS00697) ATP-dependent DNA ligase AMP-binding site signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-DEPENDENT DNA LIGASE FAMILY. X2BMJ3,Q7TTR7 No information pathways Rv3062 NC_002945.3 Mycobrowser_v2 CDS 3378287 3379759 . - 0 Mb3086c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb3086c, -, len: 490 aa. Equivalent to Rv3060c,len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 490 aa overlap). Probable transcriptional regulatory protein, showing reasonable similarity to several members of the GntR family e.g. BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 274, E(): 3.5e-10, (30.35% identity in 224 aa overlap); P96570|ESMR from Burkholderia cepacia (Pseudomonas cepacia) (277 aa), FASTA scores: opt: 229, E(): 2.8e-07, (25.85% identity in 240 aa overlap); Q9S276|SCI28.07 from Streptomyces coelicolor (230 aa),FASTA scores: opt: 211, E(): 3.4e-06, (27.25% identity in 220 aa overlap); etc. Seems to have two domains: residues 1-260 resemble UxuR, and 260-490 resemble PdhR, ExuR, etc. Contains bacterial regulatory proteins, GntR family signature (PS00043). Helix-turn-helix motif (+3.13 SD) at aa 38-59. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TXC5 No regulatory proteins Rv3060c NC_002945.3 Mycobrowser_v2 CDS 3386372 3386797 . - 0 Mb3091c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3091c, -, len: 141 aa. Equivalent to Rv3064c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Probable conserved integral membrane protein, similar to many e.g. Q9KY40|SCC8A.08 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 391,E(): 2.4e-18, (48.45% identity in 130 aa overlap); Q9K461|SC2H12.23c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 339,E(): 5.1e-15, (46.7% identity in 124 aa overlap); BAB48975|MLR1652 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (130 aa), FASTA scores: opt: 319,E(): 8.7e-14, (41.45% identity in 123 aa overlap); Q9JR31|NMA2196|NMB0291 CONSERVED HYPOTHETICAL INNER MEMBRANE PROTEIN from Neisseria meningitidis serogroup A and B (132 aa), FASTA scores: opt: 303, E(): 9.4e-13,(43.65% identity in 126 aa overlap); etc. Q7TXC1 No cell wall and cell processes Rv3064c NC_002945.3 Mycobrowser_v2 CDS 3379808 3381610 . - 0 Mb3087c fadE22b PROBABLE ACYL-COA DEHYDROGENASE FADE22b [SECOND PART] Mb3087c, fadE22b, len: 600 aa. Equivalent to 3' end of Rv3061c, len: 721 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 600 aa overlap). Probable fadE22, Acyl-CoA Dehydrogenase (EC 1.3.99.-),similar to many e.g. AAK44503|MT0284 from Mycobacterium tuberculosis strain CDC1551 (731 aa), FASTA scores: opt: 1804, E(): 1.1e-101, (43.45% identity in 743 aa overlap); AAK48037|MT3678 from Mycobacterium tuberculosis strain CDC1551 (711 aa), FASTA scores: opt: 1630, E(): 3.9e-91,(42.55% identity in 733 aa overlap); and extensive similarity in C-terminal part to many acyl-CoA dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 767, E(): 4.8e-39,(36.7% identity in 376 aa overlap). Also similar to many hypothetical proteins. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits fadE22 into 2 parts,fadE22a and fadE22b. Q7TXC4 No NC_002945.3 Mycobrowser_v2 CDS 3381630 3381974 . - 0 Mb3088c fadE22a PROBABLE ACYL-COA DEHYDROGENASE FADE22a [FIRST PART] Mb3088c, fadE22a, len: 114 aa. Equivalent to 5' end of Rv3061c, len: 721 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 111 aa overlap). Probable fadE22, Acyl-CoA Dehydrogenase (EC 1.3.99.-),similar to many e.g. AAK44503|MT0284 from Mycobacterium tuberculosis strain CDC1551 (731 aa), FASTA scores: opt: 1804, E(): 1.1e-101, (43.45% identity in 743 aa overlap); AAK48037|MT3678 from Mycobacterium tuberculosis strain CDC1551 (711 aa), FASTA scores: opt: 1630, E(): 3.9e-91,(42.55% identity in 733 aa overlap); and extensive similarity in C-terminal part to many acyl-CoA dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 767, E(): 4.8e-39,(36.7% identity in 376 aa overlap). Also similar to many hypothetical proteins. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits fadE22 into 2 parts,fadE22a and fadE22b. Q7TXC3 No NC_002945.3 Mycobrowser_v2 CDS 3425848 3426330 . - 0 Mb3127c smpB PROBABLE SSRA-BINDING PROTEIN SMPB Mb3127c, smpB, len: 160 aa. Equivalent to Rv3100c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Probable smpB, small protein b related to several bacterial small protein b homologs e.g. O32881|SSRP_MYCLE|ML0671|MLCB1779.19c from Mycobacterium leprae (160 aa), FASTA scores: opt: 914,E(): 1.1e-52, (84.9% identity in 159 aa overlap); Q9L1S9|SMPB from Streptomyces coelicolor (159 aa), FASTA scores: opt: 568, E(): 3.3e-30, (55.15% identity in 145 aa overlap); O32230|SSRP_BACSU from Bacillus subtilis (156 aa), FASTA scores: opt: 511, E(): 1.7e-26, (47.05% identity in 153 aa overlap); etc. BELONGS TO THE SSRP FAMILY. X2BMB6,P0A613 No NC_002945.3 Mycobrowser_v2 CDS 3383790 3386066 . + 0 Mb3090 cstA PROBABLE CARBON STARVATION PROTEIN A HOMOLOG CSTA Mb3090, cstA, len: 758 aa. Equivalent to Rv3063,len: 758 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 758 aa overlap). Probable cstA,integral membrane starvation-induced stress response protein, similar to other e.g. P15078|CSTA_ECOLI|B0598 from Escherichia coli strain K12 (701 aa), FASTA scores: opt: 2357, E(): 9.5e-137, (51.25% identity in 712 aa overlap); AAG54933|CSTA from Escherichia coli strain O157:H7 EDL933 (701 aa), FASTA scores: opt: 2356, E(): 1.1e-136, (51.1% identity in 712 aa overlap); etc. Predicted to be membrane associated. Similarity suggests start at GTG at 16801 in Y22D7 but no RBS obvious so TBparse-predicted start at 16881 taken. BELONGS TO THE CSTA FAMILY. Q7TXC2 No virulence, detoxification, adaptation Rv3063 NC_002945.3 Mycobrowser_v2 CDS 3386934 3387257 . + 0 Mb3092 mmr MULTIDRUGS-TRANSPORT INTEGRAL MEMBRANE PROTEIN MMR Mb3092, mmr, len: 107 aa. Equivalent to Rv3065,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 107 aa overlap). mmr, integral membrane multidrugs resistance transporter (see citation below), equivalent to Q9CBP1|ML1756 PROBABLE MULTIDRUG RESISTANCE PROTEIN from Mycobacterium leprae (107 aa),FASTA scores: opt: 534, E(): 3.3e-28, (77.55% identity in 107 aa overlap). Also highly similar to bacterial proteins involved in resistance to ethidium bromide or methyl viologen e.g. O87866|QACG_STASP QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACG (QUARTERNARY AMMONIUM DETERMINANT G) from Staphylococcus sp. strain ST94 (107 aa), FASTA scores: opt: 307, E(): 1.8e-13, (39.8% identity in 103 aa overlap); P96460|QAC QUATERNARY AMMONIUM COMPOUNDS RESISTANCE PROTEIN QAC from Staphylococcus aureus (107 aa), FASTA scores: opt: 304, E(): 2.8e-13,(40.4% identity in 104 aa overlap); Q57225|QACE_ECOLI QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACE (QUARTERNARY AMMONIUM DETERMINANT E) from Escherichia coli (110 aa), FASTA scores: opt: 300, E(): 5.2e-13, (48.15% identity in 108 aa overlap); AAG55967|Z1870 METHYLVIOLOGEN RESISTANCE PROTEIN ENCODED WITHIN PROPHAGE CP-933X from Escherichia coli strain O157:H7 EDL933 (110 aa); P23895|EMRE|MVRC|EB|B0543 EMRE PROTEIN from Escherichia coli (110 aa), FASTA scores: opt: 290, E(): 2.3e-12,(43.55% identity in 101 aa overlap); etc. Also similar to the SugE protein of enteric bacteria. BELONGS TO THE SMALL MULTIDRUG RESISTANCE (SMR) PROTEIN FAMILY. Note that previously known as emrE. X2BN92,P69927 No cell wall and cell processes Rv3065 NC_002945.3 Mycobrowser_v2 CDS 3387254 3387862 . + 0 Mb3093 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY) Mb3093, -, len: 202 aa. Equivalent to Rv3066, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Probable transcriptional regulatory protein deoR-family, with some similarity to transcriptional regulators and hypothetical proteins, e.g. Q9X9V5|SCI7.35c HYPOTHETICAL 21.1 KDA PROTEIN from Streptomyces coelicolor (197 aa), FASTA scores: opt: 398, E(): 5.7e-19, (40.3% identity in 191 aa overlap); AAG55222|Z1073 PUTATIVE DEOR-TYPE TRANSCRIPTIONAL REGULATOR from Escherichia coli strain O157:H7 EDL933 (178 aa), FASTA scores: opt: 257, E(): 7.9e-10, (28.4% identity in 176 aa overlap); Q9HXU1|PA3699 PROBABLE TRANSCRIPTIONAL REGULATOR (TETR/ACRR FAMILY) from Pseudomonas aeruginosa (237 aa), FASTA scores: opt: 229,E(): 6.7e-08, (32.1% identity in 187 aa overlap); etc. Q7TXC0 No regulatory proteins Rv3066 NC_002945.3 Mycobrowser_v2 CDS 3388526 3390169 . - 0 Mb3095c pgmA PROBABLE PHOSPHOGLUCOMUTASE PGMA (GLUCOSE PHOSPHOMUTASE) (PGM) Mb3095c, pgmA, len: 547 aa. Equivalent to Rv3068c,len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 547 aa overlap). Probable pgmA,phosphoglucomutase (EC 5.4.2.2), highly similar to other phosphoglucomutases e.g. Q9L117|PGM from Streptomyces coelicolor (546 aa), FASTA scores: opt: 2569, E(): 2.8e-149, (71.4% identity in 545 aa overlap); Q9ABY5|CC0085 from Caulobacter crescentus (545 aa), FASTA scores: opt: 2465, E(): 6.2e-143, (70.4% identity in 541 aa overlap); P38569|PGMU_ACEXY|CELB from Acetobacter xylinum (555 aa), FASTA scores: opt: 2206, E(): 4e-127,(62.25% identity in 543 aa overlap); P74643|PGM|SLL0726 from Synechocystis sp. strain PCC 6803 (567 aa), FASTA scores: opt: 2168, E(): 8.5e-125, (60.0% identity in 550 aa overlap); P36938|PGMU_ECOLI|PGM|B0688 from Escherichia coli (546 aa), FASTA scores: opt: 2111, E(): 2.5e-121,(58.2% identity in 550 aa overlap). Also similar to other phosphomannomutases. Has phosphoglucomutase and phosphomannomutase signature (PS00710) and ATP/GTP-binding site motif A (P-loop) (PS00017). BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. Q7TXB8 No NC_002945.3 Mycobrowser_v2 CDS 3390239 3390637 . + 0 Mb3096 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3096, -, len: 132 aa. Equivalent to Rv3069, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Probable conserved transmembrane protein, similar to several hypothetical and CRCB bacterial proteins e.g. Q9A6V2|CC1981 CRCB PROTEIN (see citation below; seems to be involved in camphor resistance and chromosome condensation, promoting or protecting chromosome folding) from Caulobacter crescentus (127 aa), FASTA scores: opt: 275, E(): 1.6e-11, (41.1% identity in 124 aa overlap); Q9FC39|SC4G1.10 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 258, E(): 2.5e-10, (42.15% identity in 121 aa overlap); Q9V0X2|PAB1925 CRCB PROTEIN (see citation below) from Pyrococcus abyssi (123 aa),FASTA scores: opt: 256, E(): 2.8e-10, (39.8% identity in 113 aa overlap); O59171|PH1502 HYPOTHETICAL 13.6 KDA PROTEIN from Pyrococcus horikoshii (123 aa), FASTA scores: opt: 249, E(): 8.2e-10, (38.65% identity in 119 aa overlap); etc. X2BMZ5,P63863 No cell wall and cell processes Rv3069 NC_002945.3 Mycobrowser_v2 CDS 3390634 3391014 . + 0 Mb3097 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3097, -, len: 126 aa. Equivalent to Rv3070, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Probable conserved integral membrane protein, similar to several hypothetical and CRCB bacterial proteins e.g. Q9FC37|SC4G1.12 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (124 aa), FASTA scores: opt: 280, E(): 3.1e-11, (45.3% identity in 117 aa overlap); O25823|HP1225 CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Helicobacter pylori (Campylobacter pylori) (130 aa), FASTA scores: opt: 225, E(): 1e-07, (33.35% identity in 123 aa overlap); O07590|YHDU HYPOTHETICAL 12.4 KDA PROTEIN from Bacillus subtilis (118 aa), FASTA scores: opt: 224, E(): 1.1e-07,(37.85% identity in 111 aa overlap); Q9KVS9|VC0060 CRCB PROTEIN (see citation below; seems involved in camphor resistance and chromosome condensation, promoting or protecting chromosome folding) from Vibrio cholera (126 aa), FASTA scores: opt: 221, E(): 1.8e-07, (33.35% identity in 126 aa overlap); etc. X2BN96,P63865 No cell wall and cell processes Rv3070 NC_002945.3 Mycobrowser_v2 CDS 3391011 3392120 . + 0 Mb3098 CONSERVED HYPOTHETICAL PROTEIN Mb3098, -, len: 369 aa. Equivalent to Rv3071, len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Conserved hypothetical protein, weakly similar in N-terminus of Q9A4V0|CC2725 HYPOTHETICAL PROTEIN CC2725 from Caulobacter crescentus (113 aa), FASTA scores: opt: 141, E(): 0.031,(27.6% identity in 105 aa overlap). C-terminal region also weakly similar to other hypothetical proteins e.g. Q9FC38|YG11_STRCO from Streptomyces coelicolor (114 aa),FASTA scores: opt: 151, E(): 0.007, (31.65% identity in 98 aa overlap). Q7TXB7 No conserved hypotheticals Rv3071 NC_002945.3 Mycobrowser_v2 CDS 3442341 3442835 . + 0 Mb3146 HYPOTHETICAL PROTEIN Mb3146, -, len: 164 aa. Equivalent to Rv3123, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Hypothetical unknown protein, but N-terminus shares weak similarity with N-terminal part of O93439|CMESO-1 BHLH TRANSCRIPTION FACTOR from Gallus gallus (Chicken) (287 aa), FASTA scores: opt: 129, E(): 0.81, (38.75% identity in 80 aa overlap). Q7TX78 No conserved hypotheticals Rv3123 NC_002945.3 Mycobrowser_v2 CDS 3396088 3397899 . + 0 Mb3104 POSSIBLE HYDROLASE Mb3104, -, len: 603 aa. Equivalent to Rv3077, len: 603 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 603 aa overlap). Possible hydrolase (EC 3.1.-.-), with some similarity to variety of hydrolases (aryl- and steryl sulfatases principaly) e.g. Q45087|PEHA PHOSPHONATE MONOESTER HYDROLASE from Burkholderia caryophylli (514 aa), FASTA scores: opt: 239, E(): 7.2e-07, (23.95% identity in 413 aa overlap); Q9I1E5|PA2333 PROBABLE SULFATASE from Pseudomonas aeruginosa (538 aa), FASTA scores: opt: 231, E(): 2.3e-06,(28.1% identity in 516 aa overlap); P31447|YIDJ_ECOLI|B3678 PUTATIVE SULFATASE (EC 3.1.6.-) from Escherichia coli (497 aa), FASTA scores: opt: 222,E(): 7.4e-06, (27.7% identity in 390 aa overlap); etc. Note that previously known as atsF. Q7TXB2 No intermediary metabolism and respiration Rv3077 NC_002945.3 Mycobrowser_v2 CDS 3392876 3393232 . - 0 Mb3100c CONSERVED HYPOTHETICAL PROTEIN Mb3100c, -, len: 118 aa. Equivalent to Rv3073c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein, highly similar to other e.g. Q9F3D7|SC2H2.18 from Streptomyces coelicolor (119 aa),FASTA scores: opt: 399, E(): 2.5e-20, (53.05% identity in 115 aa overlap); Q9K4K9|SC5F8.15c from Streptomyces coelicolor (117 aa), FASTA scores: opt: 334, E(): 6e-16,(49.1% identity in 112 aa overlap); Q9HKD5|TA0666 from Thermoplasma acidophilum (134 aa), FASTA scores: opt: 334,E(): 6.7e-16, (42.35% identity in 111 aa overlap); BAB53507|MLL7394 from Rhizobium loti (Mesorhizobium loti) (120 aa), FASTA scores: opt: 309, E(): 3e-14, (43.65% identity in 110 aa overlap); etc. X2BMJ4 No conserved hypotheticals Rv3073c NC_002945.3 Mycobrowser_v2 CDS 3393326 3394600 . + 0 Mb3101 CONSERVED HYPOTHETICAL PROTEIN Mb3101, -, len: 424 aa. Equivalent to Rv3074, len: 424 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 424 aa overlap). Conserved hypothetical protein, highly similar but shorter (46 aa) to P71806|Rv1378c|MTCY02B12.12c HYPOTHETICAL 51.3 KDA PROTEIN from Mycobacterium tuberculosis (475 aa), FASTA scores: opt: 2009, E(): 5.8e-113, (72.95% identity in 429 aa overlap); and also similar to other hypothetical mycobacterium proteins e.g. O33266|Rv0336|MTCY279.03 (503 aa), FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); O33360|Rv0515|MTCY20G10.05 (503 aa),FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); etc. Q7TXB5 No conserved hypotheticals Rv3074 NC_002945.3 Mycobrowser_v2 CDS 3394597 3395520 . - 0 Mb3102c conserved protein Mb3102c, -, len: 307 aa. Equivalent to Rv3075c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Conserved hypopthetical protein, with some similarity to Q9I562|PA0883 PROBABLE ACYL-COA LYASE BETA CHAIN from Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 408,E(): 9.2e-19, (35.15% identity in 273 aa overlap); Q9S2U9|SC4G6.02 PUTATIVE CITRATE LYASE BETA CHAIN from Streptomyces coelicolor (274 aa), FASTA scores: opt: 384,E(): 3.1e-17, (34.7% identity in 265 aa overlap); O06162|CITE|Rv2498c|MTCY07A7.04c from Mycobacterium tuberculosis (273 aa), FASTA scores: opt: 349, E(): 5.1e-15, (35.2% identity in 264 aa overlap); etc. Several initiation codons possible, first one chosen. Q7TXB4 No conserved hypotheticals Rv3075c NC_002945.3 Mycobrowser_v2 CDS 3397900 3398301 . + 0 Mb3105 hab PROBABLE HYDROXYLAMINOBENZENE MUTASE HAB Mb3105, hab, len: 133 aa. Equivalent to Rv3078,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable hab,hydroxylaminobenzene mutase (5.-.-.-) (see experiments in first citation), highly similar to two hydroxylaminobenzene mutases from Pseudomonas pseudoalcaligenes O52214|HABA (135 aa), FASTA scores: opt: 495, E(): 6.8e-25, (51.1% identity in 133 aa overlap); and O52216|HABB (164 aa), FASTA scores: opt: 479, E(): 8.2e-24, (51.9% identity in 133 aa overlap) (see first citation); and to Q9AH35|NBZB HYDROXYLAMINOBENZENE MUTASE from Pseudomonas putida (164 aa), FASTA scores: opt: 476,E(): 1.3e-23, (51.8% identity in 133 aa overlap) (see second citation). Gene name according to Pseudomonas pseudoalcaligenes nomenclature. Also similarity with putative different membrane proteins involved in transport (protein predicted to be a transmembrane protein). Q7TXB1 No intermediary metabolism and respiration Rv3078 NC_002945.3 Mycobrowser_v2 CDS 3398317 3399144 . - 0 Mb3106c conserved protein Mb3106c, -, len: 275 aa. Equivalent to Rv3079c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Conserved hypothetical protein, similar to other hypothetical mycobacterium proteins e.g. P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 POSSIBLE OXIDOREDUCTASE from Mycobacterium tuberculosis strain H37Rv (282 aa), FASTA scores: opt: 668, E(): 2.4e-34,(40.55% identity in 281 aa overlap); O06216|Rv2161c|MTCY270.07 from M. tuberculosis strain H37Rv (288 aa), FASTA scores: opt: 595, E(): 8.5e-30,(40.9% identity in 274 aa overlap); O87779 from Mycobacterium paratuberculosis (166 aa), FASTA scores: opt: 464, E(): 7.2e-22, (41.55% identity in 166 aa overlap); etc. Also some similarity to other proteins e.g. Q9AH10 PUTATIVE F420-DEPENDENT DEHYDROGENASE from Rhodococcus erythropolis (295 aa), FASTA scores: opt: 401,E(): 9.6e-18, (30.2% identity in 288 aa overlap); Q9AE04|RIF17 RIF17 PROTEIN from Amycolatopsis mediterranei (356 aa), FASTA scores: opt: 298, E(): 2.8e-11, (35.0% identity in 203 aa overlap); AAK48081|MT3720 LUCIFERASE-RELATED PROTEIN from Mycobacterium tuberculosis strain CDC1551 (395 aa), FASTA scores: opt: 223, E(): 1.4e-06, (29.4% identity in 211 aa overlap). Q7TXB0 No conserved hypotheticals Rv3079c NC_002945.3 Mycobrowser_v2 CDS 3399203 3402535 . - 0 Mb3107c pknK serine/threonine-protein kinase transcriptional regulatory protein pknk (protein kinase k) (stpk k) Mb3107c, pknK, len: 1110 aa. Equivalent to Rv3080c,len: 1110 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1110 aa overlap). Probable pknK,serine/threonine protein kinase involved in transcriptional regulatory function (EC 2.7.1.-) (see citation below). Similar but shorter in N-terminus (approximatively 300 residues) to others e.g. Q48411|ACOK TRANSCRIPTIONAL REGULATORY PROTEIN OF aco ABCD operon from Klebsiella pneumoniae (921 aa), FASTA scores: opt: 886,E(): 7.6e-37, (27.75% identity in 829 aa overlap); Q9HX92|PA3921 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (906 aa), FASTA scores: opt: 760, E(): 1.5e-30, (29.55% identity in 822 aa overlap); Q9I2X9|PA1760 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (907 aa), FASTA scores: opt: 696, E(): 2.3e-27, (25.85% identity in 685 aa overlap); P06993|MALT (alias BAB37683|ECS4260 and AAG58520|MALT) POSITIVE REGULATOR OF MAL REGULON from Escherichia coli strain O157:H7 (901 aa), FASTA scores: opt: 660, E(): 1.4e-25, (29.25% identity in 530 aa overlap); Q9KNF3|VCA0011 MALT REGULATORY PROTEIN from Vibrio cholerae (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (921 aa), FASTA scores: opt: 626, E(): 7.2e-24, (25.8% identity in 659 aa overlap); etc. N-terminal region similar to N-terminus of serine/threonine kinases e.g. Q9KK90|PKMA SERINE/THREONINE KINASE (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (589 aa), FASTA scores: opt: 545, E(): 5.7e-20, (34.45% identity in 334 aa overlap); Q9RPT5|AMK SERINE/THREONINE PROTEIN KINASE HOMOLOG (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (606 aa), FASTA scores: opt: 537, E(): 1.5e-19, (35.55% identity in 346 aa overlap); Q9L0I0|PKAD PROTEIN SERINE/THREONINE KINASE from Streptomyces coelicolor (599 aa), FASTA scores: opt: 520,E(): 1e-18, (36.1% identity in 324 aa overlap); etc. N-terminal part also similar to O53510|PKNL_MYCTU|Rv2176|MT2232|MTV021.09 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis strain H37Rv (399 aa), FASTA scores: opt: 511, E(): 2.1e-18, (35.15% identity in 313 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains Hank's kinase subdomain. FIRST PART OF THE PROTEIN SEEMS BELONG TO THE SER/THR FAMILY OF PROTEIN KINASES, AND SECOND PARTS SEEMS BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. X2BNB1,Q7TXA9 No NC_002945.3 Mycobrowser_v2 CDS 3418307 3419311 . - 0 Mb3120c HYPOTHETICAL OXIDOREDUCTASE Mb3120c, -, len: 334 aa. Equivalent to Rv3093c,len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 334 aa overlap). Hypothetical oxidoreductase (EC 1.-.-.-), with some similarity with various oxidoreductases e.g. Q58929|MER|MJ1534 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 300, E(): 1.1e-10, (24.1% identity in 324 aa overlap); and Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa),FASTA scores: opt: 264, E(): 1.5e-08, (30.45% identity in 335 aa overlap); Q9CCV8|ML0348 POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE from Mycobacterium leprae (350 aa), FASTA scores: opt: 220, E(): 6.4e-06, (26.5% identity in 328 aa overlap); etc. Q7TX97 No intermediary metabolism and respiration Rv3093c NC_002945.3 Mycobrowser_v2 CDS 3721748 3722119 . - 0 Mb3387c POSSIBLE OXIDOREDUCTASE Mb3387c, -, len: 123 aa. Equivalent to Rv3352c,len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 123 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to part of several oxidoreductases (and hypothetical proteins) from diverse organisms e.g. Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 348, E(): 7.9e-15, (51.0% identity in 102 aa overlap); BAB53081|MLR6875 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (479 aa), FASTA scores: opt: 262, E(): 2.3e-09, (53.85% identity in 78 aa overlap); O94206|OX1 OXIDOREDUCTASE from Claviceps purpurea (Ergot fungus) (483 aa), FASTA scores: opt: 245,E(): 2.7e-08, (42.6% identity in 115 aa overlap); Q9KHK2|ENCM PUTATIVE FAD-DEPENDENT OXYGENASE ENCM from Streptomyces maritimus (464 aa), FASTA scores: opt: 238,E(): 7.2e-08, (43.95% identity in 91 aa overlap); etc. Also highly similar to part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE (479 aa), FASTA scores: opt: 599, E(): 1.6e-30, (71.55% identity in 123 aa overlap); and to other Mycobacterium tuberculosis proteins e.g. Rv3353c and Rv3351c. All show similarity to a family of oxidoreductases in M. tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found. Q7TWN4 No intermediary metabolism and respiration Rv3352c NC_002945.3 Mycobrowser_v2 CDS 3402587 3403825 . + 0 Mb3108 CONSERVED HYPOTHETICAL PROTEIN Mb3108, -, len: 412 aa. Equivalent to Rv3081, len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 412 aa overlap). Conserved hypothetical protein. Second part of the protein (approximatively residues 250-412) shares weak similarity with other hypothetical proteins e.g. Q9YEU3|APE0488 from Aeropyrum pernix (188 aa), FASTA scores: opt: 149, E(): 0.019, E(): 0.019, (29.5% identity in 173 aa overlap); and first part shares weak similarity with C-terminal part of Q9RVT9|DR0933 ALPHA-AMLYASE from Deinococcus radiodurans (644 aa), FASTA scores: opt: 127, E(): 1.4, (27.25% identity in 198 aa overlap). Equivalent to AAK47502|MT3166 HYPOTHETICAL 48.3 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (436 aa) but shorter 24 aa in N-terminus. Contains PS00850 Glycine radical signature and possible helix-turn-helix motif at aa 53-74. Q7TXA8 No conserved hypotheticals Rv3081 NC_002945.3 Mycobrowser_v2 CDS 3403951 3404973 . - 0 Mb3109c virS VIRULENCE-REGULATING TRANSCRIPTIONAL REGULATOR VIRS (ARAC/XYLS FAMILY) Mb3109c, virS, len: 340 aa. Equivalent to Rv3082c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). virS, transcriptional regulatory protein araC/xylS family, probably involved in virulence (see citation below). Similar to many transcriptional regulators araC/xylS family e.g. Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR (ARAC/XYLS FAMILY) from Pseudomonas aeruginosa (337 aa),FASTA scores: opt: 379, E(): 3e-17, (30.4% identity in 306 aa overlap); Q9Z3Y6|PHBR POLYHYDROXYBUTYRATE TRANSCRIPTIONAL ACTIVATOR from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 336, E(): 2e-14, (26.35% identity in 334 aa overlap); P72171|ORUR|PA0831 ORNITHINE UTILIZATION TRANSCRIPTIONAL REGULATOR oruR from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 274,E(): 1.9e-10, (23.7% identity in 321 aa overlap); Q9ZFW7 VIRULENCE REGULATING HOMOLOG from Pseudomonas alcaligenes (346 aa), FASTA scores: opt: 262, E(): 1.2e-09, (24.5% identity in 339 aa overlap); etc. Also similar to O69703|Rv3736|MTV025.084 PUTATIVE REGULATORY PROTEIN (ARAC/XYLS FAMILY) from Mycobacterium tuberculosis strain H37Rv (353 aa), FASTA scores: opt: 656, E(): 3.5e-35,(36.95% identity in 333 aa overlap). Has potential helix-turn-helix motif at positions 252-273. BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TXA7 No NC_002945.3 Mycobrowser_v2 CDS 3405051 3406538 . + 0 Mb3110 PROBABLE MONOOXYGENASE (HYDROXYLASE) Mb3110, -, len: 495 aa. Equivalent to Rv3083, len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Probable monooxygenase (EC 1.-.-.-), highly similar to other putative monooxygenases flavin-binding family e.g. AAK48336|MT3969 from Mycobacterium tuberculosis strain CDC1551 (489 aa),FASTA scores: opt: 1692, E(): 4.9e-98, (49.7% identity in 489 aa overlap); Q9A588|CC2569 from Caulobacter crescentus (498 aa), FASTA scores: opt: 1684, E(): 1.6e-97, (52.25% identity in 484 aa overlap); Q9APW3 from Pseudomonas aeruginosa (508 aa), FASTA scores: opt: 1603, E(): 1.8e-92, (49.8% identity in 484 aa overlap); etc. Q7TXA6 No intermediary metabolism and respiration Rv3083 NC_002945.3 Mycobrowser_v2 CDS 3406544 3407470 . + 0 Mb3111 lipR PROBABLE ACETYL-HYDROLASE/ESTERASE LIPR Mb3111, lipR, len: 308 aa. Equivalent to Rv3084,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable lipR,N-Acetyl-hydrolase/esterase (EC 3.1.1.-), similar to other e.g. Q01109|BAH_STRH from Streptomyces hygroscopicus (299 aa), FASTA scores: opt: 558, E(): 4.1e-26, (40.25% identity in 246 aa overlap); Q9X8J4|SCE9.22 from Streptomyces coelicolor (266 aa), FASTA scores: opt: 544,E(): 2.5e-25, (36.95% identity in 257 aa overlap); Q56171|DEA from Streptomyces viridochromogenes (299 aa),FASTA scores: opt: 532, E(): 1.4e-24, (38.6% identity in 254 aa overlap); etc. Also similar to O06350|LIPF|Rv3487c|MTCY13E12.41c (277 aa), FASTA score: opt: 291, E(): 8.5e-10, (28.5% identity in 239 aa overlap). MAY BE BELONG TO THE 'GDXG' FAMILY OF LIPOLYTIC ENZYMES. Q7TXA5 No intermediary metabolism and respiration Rv3084 NC_002945.3 Mycobrowser_v2 CDS 3407467 3408297 . + 0 Mb3112 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb3112, -, len: 276 aa. Equivalent to Rv3085, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various oxidoreductases in the short chain dehydrogenases/reductases family e.g. Q9CC98|ML1094 SHORT CHAIN ALCOHOL DEHYDROGENASE from Mycobacterium leprae (277 aa), FASTA scores: opt: 1059, E(): 4.8e-56, (61.65% identity in 266 aa overlap); Q9I3H6|PA1537 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginos (295 aa), FASTA scores: opt: 858, E(): 4.7e-44, (48.4% identity in 285 aa overlap); Q9CBP7|ML1740 POSSIBLE SHORT CHAIN REDUCTASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 500, E(): 1e-22, (36.6% identity in 257 aa overlap); etc. Also similar to mycobacterium proteins O50460|Rv1245c|MTV006.17c DEHYDROGENASE SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (276 aa),FASTA scores: opt: 1200, E(): 1.9e-64, (65.2% identity in 273 aa overlap); and P95101|Rv3057c|MTCY22D7.24 HYPOTHETICAL DEHYDROGENASE (287 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TXA4 No intermediary metabolism and respiration Rv3085 NC_002945.3 Mycobrowser_v2 CDS 3408328 3409434 . + 0 Mb3113 adhD PROBABLE ZINC-TYPE ALCOHOL DEHYDROGENASE ADHD (ALDEHYDE REDUCTASE) Mb3113, adhD, len: 368 aa. Equivalent to Rv3086,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 368 aa overlap). Probable adhD,zinc-type alcohol dehydrogenase (EC 1.1.1.-), highly similar to many e.g. O69045 HYPOTHETICAL ALCOHOL DEHYDROGENASE from Rhodococcus rhodochrous (370 aa), FASTA scores: opt: 1255, E(): 8.7e-68, (50.4% identity in 367 aa overlap); P25406|ADHB_UROHA ALCOHOL DEHYDROGENASE I-B from Uromastyx hardwickii (Indian spiny-tailed lizard) (375 aa), FASTA scores: opt: 787, E(): 8.2e-40, (35.9% identity in 373 aa overlap); P72324||ADHI_RHOSH ALCOHOL DEHYDROGENASE CLASS III from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (376 aa), FASTA scores: opt: 787, E(): 8.3e-40, (35.1% identity in 379 aa overlap). Also highly similar to P71818|Rv0761c|MTCY369.06c HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN from Mycobacterium tuberculosis strain H37Rv (375 aa), FASTA scores: opt: 1186, E(): 1.2e-63, (47.3% identity in 368 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE. POSSIBLY REQUIRES ZINC FOR ITS ACTIVITY. Q7TXA3 No intermediary metabolism and respiration Rv3086 NC_002945.3 Mycobrowser_v2 CDS 3409472 3410890 . + 0 Mb3114 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb3114, -, len: 472 aa. Equivalent to Rv3087, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 472 aa overlap). Hypothetical protein,similar to several Mycobacterium tuberculosis proteins e.g. MTCY08D5.16, MTCY28.26, MTCY493.29c. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa). Q7TXA2 No lipid metabolism Rv3087 NC_002945.3 Mycobrowser_v2 CDS 3410887 3412311 . + 0 Mb3115 tgs4 putative triacylglycerol synthase (diacylglycerol acyltransferase) tgs4 Mb3115, -, len: 474 aa. Equivalent to Rv3088, len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 474 aa overlap). Hypothetical protein,similar to several Mycobacterium tuberculosis proteins e.g. MTCY31.23 (505 aa), MTCY13E12.34c (497 aa) and MTCY493.29c (459 aa). Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa). X2BML1,P67209 No lipid metabolism Rv3088 NC_002945.3 Mycobrowser_v2 CDS 3412308 3413819 . + 0 Mb3116 fadD13 PROBABLE CHAIN-FATTY-ACID-CoA LIGASE FADD13 (FATTY-ACYL-CoA SYNTHETASE) Mb3116, fadD13, len: 503 aa. Equivalent to Rv3089,len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Probable fadD13,Acyl-CoA Synthetase (EC 6.2.1.-), similar to many e.g. MTCI28.06, MTCY08D5.09, MTCY06G11.08 from Mycobacterium tuberculosis strain H37Rv; and to Q9F7P5 PREDICTED ACID--CoA LIGASE FADD13 from uncultured proteobacterium EBAC31A08 (504 aa), FASTA scores: opt: 1126, E(): 2.4e-62,(38.85% identity in 502 aa overlap); Q9EY88|FCS FERULOYL-CoA SYNTHETASE from Amycolatopsis sp. strain HR167 (491 aa), FASTA scores: opt: 1073, E(): 4.5e-59,(38.5% identity in 504 aa overlap); BAB49118|MLR1843 PROBABLE ACID-CoA LIGASE from Rhizobium loti (Mesorhizobium loti) (495 aa), FASTA scores: opt: 937,E(): 1.2e-50, (36.2% identity in 503 aa overlap); Q9KZC1|SC6F7.21 PROBABLE LONG-CHAIN-FATTY-ACID-CoA LIGASE from Streptomyces coelicolor (511 aa), FASTA scores: opt: 899, E(): 2.8e-48, (36.1% identity in 510 aa overlap); Q9A5P7|CC2400 PUTATIVE ACID-CoA LIGASE from Caulobacter crescentus (496 aa), FASTA scores: opt: 874, E(): 9.8e-47,(35.1% identity in 507 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature and PS00061 Short-chain alcohol dehydrogenase family signature. TBparse score is 0.877. Q7TXA1 No NC_002945.3 Mycobrowser_v2 CDS 3427227 3427916 . - 0 Mb3129c ftsE PUTATIVE CELL DIVISION ATP-BINDING PROTEIN FTSE (SEPTATION COMPONENT-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER) Mb3129c, ftsE, len: 229 aa. Equivalent to Rv3102c,len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Putative ftsE, cell division protein, septation component transport ATP-binding protein ABC transporter (see citations below),equivalent to O32883|FTSE|ML0669 CELL DIVISION ATP-BINDING PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1384, E(): 2.4e-74, (91.7% identity in 229 aa overlap); and similar to Q9L1S6|FTSE from Streptomyces coelicolor (229 aa), FASTA scores: opt: 914, E(): 8.7e-47,(62.85% identity in 226 aa overlap); Q9A0S4|FTSE|SPY0644 from Streptococcus pyogenes (230 aa), FASTA scores: opt: 866, E(): 5.7e-44, (57.9% identity in 228 aa overlap); Q9CGX0|FTSE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (230 aa), FASTA scores: opt: 792,E(): 1.3e-39, (52.2% identity in 228 aa overlap); etc. Other relatives from Mycobacterium tuberculosis include: MTCY253.24; MTCY16B7.10; MTCY9C4.04c; MTCY50.01; MTCY05A6.09c; MTCY04C12.31. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and ABC transporters family signature (PS00211). BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TX90 No NC_002945.3 Mycobrowser_v2 CDS 3417361 3418281 . - 0 Mb3119c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3119c, -, len: 306 aa. Equivalent to Rv3092c,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 306 aa overlap). Probable conserved integral membrane protein, highly similar to Q9RUT5|DR1297 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (311 aa), FASTA scores: opt: 941, E(): 9.8e-51, (55.65% identity in 309 aa overlap); Q9A8B8|CC1436 HYPOTHETICAL PROTEIN from Caulobacter crescentus (314 aa), FASTA scores: opt: 791, E(): 1.6e-41,(46.9% identity in 305 aa overlap); and also highly similar to Q9I2N8|PA1857 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (307 aa), FASTA scores: opt: 373,E(): 8.1e-16, (40.8% identity in 321 aa overlap); BAB36119|ECS2696 PUTATIVE METHYL-INDEPENDENT MISMATCH REPAIR PROTEIN from Escherichia coli strain O157:H7 (305 aa), FASTA scores: opt: 335, E(): 1.7e-13, (39.75% identity in 307 aa overlap). Q7TX98 No cell wall and cell processes Rv3092c NC_002945.3 Mycobrowser_v2 CDS 3447372 3447953 . - 0 Mb3152c CONSERVED HYPOTHETICAL PROTEIN Mb3152c, -, len: 193 aa. Equivalent to 5' end of Rv3128c, len: 337 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 193 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon but is similar throughout its length to Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 954, E(): 0, (47.2% identity in 339 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis,Rv3128c is split into 2, Mb3151c and Mb3152c. Q7TX72 No NC_002945.3 Mycobrowser_v2 CDS 3419308 3420438 . - 0 Mb3121c CONSERVED HYPOTHETICAL PROTEIN Mb3121c, -, len: 376 aa. Equivalent to Rv3094c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Conserved hypothetical protein, some similarity with various proteins e.g. Q9RMR9|NRGC NRGC PROTEIN (corresponding gene seems regulated by NifA) from Bradyrhizobium japonicum (388 aa), FASTA scores: opt: 677, E(): 5.8e-35, (34.55% identity in 353 aa overlap); P26698|PIGM_RHOSO PIGMENT PROTEIN from Rhodococcus sp. strain ATCC 21145 (387 aa),FASTA scores: opt: 480, E(): 1.2e-22, (28.7% identity in 376 aa overlap); Q9F0J3|NCNH HYDROXYLASE from Streptomyces arenae (405 aa), FASTA scores: opt: 441, E(): 3.3e-20,(29.25% identity in 352 aa overlap); etc. Equivalent to AAK47516 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but N-terminus shorter 19 aa. Q7TX96 No conserved hypotheticals Rv3094c NC_002945.3 Mycobrowser_v2 CDS 3420520 3420996 . + 0 Mb3122 HYPOTHETICAL TRANSCRIPTIONAL REGULATORY PROTEIN Mb3122, -, len: 158 aa. Equivalent to Rv3095, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Possible regulatory protein, because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa),FASTA scores: opt: 486, E(): 1.6e-25, (45.95% identity in 148 aa overlap); Q9AAF6|CC0645 from Caulobacter crescentus (188 aa), FASTA scores: opt: 479, E(): 5.3e-25, (45.75% identity in 153 aa overlap); Q9K408|2SCG61.07 from Streptomyces coelicolor (157 aa), FASTA scores: opt: 407,E(): 2.8e-20, (43.9% identity in 139 aa overlap); etc. X2BNC8,P0A649 No regulatory proteins Rv3095 NC_002945.3 Mycobrowser_v2 CDS 3536171 3537049 . - 0 Mb3230c conserved protein Mb3230c, -, len: 292 aa. Equivalent to Rv3205c,len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Hypothetical protein,highly similar to Q9CCG7|ML0818 HYPOTHETICAL PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745,E(): 9.1e-98, (87.3% identity in 291 aa overlap). Q7TX08 No conserved hypotheticals Rv3205c NC_002945.3 Mycobrowser_v2 CDS 3421094 3422233 . + 0 Mb3123 CONSERVED HYPOTHETICAL PROTEIN Mb3123, -, len: 379 aa. Equivalent to Rv3096, len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 379 aa overlap). Hypothetical protein,with slight similarity to several proteins e.g. Q09671|OYEB_SCHPO|SPAC5H10.10 PUTATIVE NADPH DEHYDROGENASE C5H10.10 (EC 1.6.99.1) (OLD YELLOW ENZYME HOMOLOG) from Schizosaccharomyces pombe (Fission yeast) (392 aa), FASTA scores: opt: 125, E(): 1.1, (25.45% identity in 165 aa overlap); and Q12603|XYNA_DICTH BETA-1,4-XYLANASE (EC 3.2.1.8) (ENDO-1,4-BETA-XYLANASE) from Dictyoglomus thermophilum (352 aa), FASTA scores: opt: 124, E(): 1.2,(25.65% identity in 195 aa overlap); etc. Contains glycosyl hydrolases family 5 signature (PS00659). TBparse score is 0.932. Q7TX95 No conserved hypotheticals Rv3096 NC_002945.3 Mycobrowser_v2 CDS 3464227 3464655 . - 0 Mb3166c HYPOTHETICAL PROTEIN Mb3166c, -, len: 142 aa. Equivalent to Rv3142c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Hypothetical unknown protein. Equivalent to AAK47569 from Mycobacterium tuberculosis strain CDC1551 but shorter 33 aa. Q7TX60 No conserved hypotheticals Rv3142c NC_002945.3 Mycobrowser_v2 CDS 3422325 3423638 . - 0 Mb3124c lipy pe-pgrs family protein, triacylglycerol lipase lipy (esterase/lipase) (triglyceride lipase) (tributyrase) Mb3124c, PE_PGRS63, len: 437 aa. Equivalent to Rv3097c, len: 437 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 437 aa overlap). Probable Triacylglycerol lipase (EC 3.1.1.3), and member of the M. tuberculosis PE-family PGRS subfamily of gly-rich proteins; N-terminal part similar to N-terminus of M. tuberculosis PE-PGRS family members e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd protein (603 aa). Other relatives include MTCY1A11.25c; MTCY21B4.13c; MTCY270.06; MTCY359.33; MTC1A11.04. Q7TX94 No NC_002945.3 Mycobrowser_v2 CDS 3426333 3427226 . - 0 Mb3128c ftsX PUTATIVE CELL DIVISION PROTEIN FTSX (SEPTATION COMPONENT-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER) Mb3128c, ftsX, len: 297 aa. Equivalent to Rv3101c,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 297 aa overlap). Putative ftsX, cell division protein, septation component transport integral membrane protein ABC transporter (see citations below),equivalent to O32882|FTSX_MYCLE|ML0670|MLCB1779.20c CELL DIVISION PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1597, E(): 9.2e-93, (80.8% identity in 297 aa overlap); and similar to others e.g. Q9L1S7|SCE59.27c from Streptomyces coelicolor (305 aa), FASTA scores: opt: 585,E(): 1.9e-29, (34.55% identity in 304 aa overlap); O34876|FTSX_BACSU from Bacillus subtilis (296 aa), FASTA scores: opt: 318, E(): 9.1e-13, (24.65% identity in 300 aa overlap); Q9K6X3|FTSX|BH3601 from Bacillus halodurans (298 aa), FASTA scores: opt: 290, E(): 5.2e-11, (22.75% identity in 299 aa overlap); etc. BELONGS TO THE FTSX FAMILY. X2BMM1,Q7TX91 No NC_002945.3 Mycobrowser_v2 CDS 3448432 3448764 . + 0 Mb3153 CONSERVED HYPOTHETICAL PROTEIN Mb3153, -, len: 110 aa. Equivalent to Rv3129, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Conserved hypothetical protein, with some similarity to various hypothetical proteins from Streptomyces coelicolor e.g. Q9RI34|SCJ12.26 HYPOTHETICAL 14.5 KDA PROTEIN (137 aa),FASTA scores: opt: 141, E(): 0.0016, (39.3% identity in 84 aa overlap); Q9RI49|SCJ12.09c HYPOTHETICAL 15.8 KDA PROTEIN (146 aa), FASTA scores: opt: 141, E(): 0.0017,(38.05% identity in 92 aa overlap); Q9RJ05|SCJ1.09C POSSIBLE DNA-BINDING PROTEIN (233 aa), FASTA scores: opt: 140, E(): 0.0029, (34.85% identity in 89 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT (334 aa); etc. Q7TX71 No conserved hypotheticals Rv3129 NC_002945.3 Mycobrowser_v2 CDS 3428399 3429325 . - 0 Mb3131c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb3131c, -, len: 308 aa. Equivalent to Rv3104c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Possible conserved transmembrane protein, with some similarity to hypthetical proteins e.g. Q9L1X9|SC8E4A.26 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (408 aa), FASTA scores: opt: 514, E(): 4.3e-25, (35.2% identity in 287 aa overlap); Q9XA89|CF43A.26c HYPOTHETICAL 36.1 KDA PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 482,E(): 3.7e-23, (34.9% identity in 301 aa overlap); Q55987|SLR0765 HYPOTHETICAL 68.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (617 aa), FASTA scores: opt: 429, E(): 1.3e-19, (30.6% identity in 278 aa overlap); etc. Q7TX88 No cell wall and cell processes Rv3104c NC_002945.3 Mycobrowser_v2 CDS 3429315 3430451 . - 0 Mb3132c prfB PROBABLE PEPTIDE CHAIN RELEASE FACTOR 2 PRFB (RF-2) Mb3132c, prfB, len: 378 aa. Equivalent to Rv3105c,len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). Probable prfB,peptide chain release factor 2, equivalent to O32885|RF2_MYCLE|ML0667|MLCB1779.24c from Mycobacterium leprae, FASTA scores: opt: 2197, E(): 1.8e-126, (90.05% identity in 372 aa overlap); and also similar to other peptide chain release factors e.g. Q9L1S3|PRFB from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1674,E(): 1.2e-94, (69.3% identity in 365 aa overlap); O67695|RF2_AQUAE|PRFB|AQ_1840 from Aquifex aeolicus (373 aa), FASTA scores: opt: 1082, E(): 1.3e-58, (44.45% identity in 369 aa overlap); P28367|RF2_BACSU from B. subtilis (366 aa), FASTA scores: opt: 1030, E(): 1.9e-55,(44.0% identity in 359 aa overlap); etc. Also related to Q10605|MTCY373.19|RF1_MYCTU|Rv1299|MT1338 peptide chain release factor 1 (rf-1) (357 aa), FASTA scores: opt: 646,E(): 1.1e-34, (38.6% identity in 350 aa overlap). Contains prokaryotic-type class I peptide chain release factors signature (PS00745). BELONGS TO THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY. X2BMC1,P66027 No NC_002945.3 Mycobrowser_v2 CDS 3464763 3465164 . + 0 Mb3167 PROBABLE RESPONSE REGULATOR Mb3167, -, len: 133 aa. Equivalent to Rv3143, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable response regulator, similar to other sensory transduction regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor (133 aa), FASTA scores: opt: 474,E(): 2.8e-24, (54.15% identity in 120 aa overlap); Q9KZ82|SCE25.04c from Streptomyces coelicolor (225 aa),FASTA scores: opt: 144, E(): 0.016, (32.3% identity in 127 aa overlap); Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa), FASTA scores: opt: 145, E(): 0.024, (30.65% identity in 124 aa overlap). SIMILAR TO OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Q7TX59 No regulatory proteins Rv3143 NC_002945.3 Mycobrowser_v2 CDS 3448747 3450138 . - 0 Mb3154c tgs1 triacylglycerol synthase (diacylglycerol acyltransferase) tgs1 Mb3154c, -, len: 463 aa. Equivalent to Rv3130c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Conserved hypothetical protein, similar to several other hypothetical Mycobacterium tuberculosis strain H37Rv proteins e.g. O06795|YH60_MYCTU|Rv1760|MTCY28.26 HYPOTHETICAL 54.1 KDA PROTEIN (502 aa), FASTA scores: opt: 586, E(): 9.8e-29, (28.95% identity in 463 aa overlap). X2BMP4,P0A651 No lipid metabolism Rv3130c NC_002945.3 Mycobrowser_v2 CDS 3435719 3436231 . + 0 Mb3138 moaC1 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C MOAC1 Mb3138, moaC1, len: 170 aa. Equivalent to Rv3111,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 170 aa overlap). Probable moaC1,molybdopterin cofactor biosynthesis protein, highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa), FASTA scores: opt: 576, E(): 2.2e-29,(62.1% identity in 153 aa overlap); Q9ZFA6|MOAC from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (159 aa), FASTA scores: opt: 541, E(): 3.4e-27, (59.85% identity in 157 aa overlap); BAB48171|MLR0616 from Rhizobium loti (Mesorhizobium loti) (160 aa), FASTA scores: opt: 531, E(): 1.5e-26, (58.75% identity in 160 aa overlap); P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa), FASTA scores: opt: 527, E(): 2.6e-26, (58.5% identity in 159 aa overlap); etc. Also highly similar to O53376|MOAC3|Rv3324c|MTV016.24c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 3 from Mycobacterium tuberculosis (177 aa), FASTA scores: opt: 738, E(): 1.7e-39, (71.5% identity in 165 aa overlap); AAK47767|MT3425 MOLYBDOPTERIN COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis strain CDC1551 (184 aa), FASTA scores: opt: 734, E(): 3.1e-39, (71.8% identity in 163 aa overlap); and Rv0864|MOAC2|MTV043.57 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 2 (167 aa). Note that previously known as moaC. X2BMM8,P0A5K5 No NC_002945.3 Mycobrowser_v2 CDS 3430555 3431925 . + 0 Mb3133 fprA nadph:adrenodoxin oxidoreductase fpra (nadph-ferredoxin reductase) Mb3133, fprA, len: 456 aa. Equivalent to Rv3106,len: 456 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 456 aa overlap). Probable fprA,NADPH:adrenodoxin oxidoreductase (EC 1.18.1.2), equivalent to O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae (456 aa), FASTA scores: opt: 2505, E(): 1.2e-142,(81,05% identity in 459 aa overlap); also similar to other NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from Deinococcus radiodurans (479 aa), FASTA scores: opt: 1331,E(): 2.6e-72, (48.9% identity in 454 aa overlap); Q9RK35|SCF15.02 from Streptomyces coelicolor (454 aa),FASTA scores: opt: 1102, E(): 1.3e-58, (41.35% identity in 462 aa overlap); P82861 from Salvelinus fontinalis (Brook trout) (498 aa), FASTA scores: opt: 827, E(): 4e-42,(41.3% identity in 460 aa overlap); Q9V3T9|ADRO_DROME from Drosophila melanogaster (Fruit fly) (466 aa), FASTA scores: opt: 790, E(): 6.3e-40, (39.45% identity in 459 aa overlap); etc. Also similar to Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium tuberculosis strain H37Rv (575 aa), FASTA scores: opt: 894, E(): 4.4e-46, (42.05% identity in 459 aa overlap). Q7TX87 No intermediary metabolism and respiration Rv3106 NC_002945.3 Mycobrowser_v2 CDS 3431926 3433509 . - 0 Mb3134c agpS POSSIBLE ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE AGPS (ALKYL-DHAP SYNTHASE) (ALKYLGLYCERONE-PHOSPHATE SYNTHASE) Mb3134c, agpS, len: 527 aa. Equivalent to Rv3107c,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 527 aa overlap). Possible agpS,alkyl-dihydroxyacetonephosphate synthase (EC 2.5.1.26),similar to others and some various enzymes e.g. AAK46595|MT2311 PUTATIVE ALKYL-DIHYDROXYACETONEPHOSPHATE SYNTHASE from Mycobacterium tuberculosis strain CDC1551 (529 aa), FASTA scores: opt: 1052, E(): 2.1e-58, (37.1% identity in 542 aa overlap); Q9RJ97|SCF91.28c PUTATIVE FLAVOPROTEIN from Streptomyces coelicolor (530 aa), FASTA scores: opt: 972, E(): 2.2e-53, (36.2% identity in 544 aa overlap); O96759|ADAS_DICDI ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE (EC 2.5.1.26) from Dictyostelium discoideum (Slime mold) (611 aa), FASTA scores: opt: 617, E(): 4.5e-31, (33.95% identity in 480 aa overlap); O97157|ADAS_TRYBB ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE from Trypanosoma brucei (613 aa), FASTA scores: opt: 567,E(): 6.2e-28, (29.15% identity in 521 aa overlap); etc. Also similar to O53525|Rv2251|MTV022.01 HYPOTHETICAL 49.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (475 aa), FASTA scores: opt: 1019, E(): 2.3e-56, (38.6% identity in 487 aa overlap). BELONGS TO THE FAD-BINDING OXIDOREDUCTASE/TRANSFERASE FAMILY 4. COFACTOR: FAD (BY SIMILARITY). Q7TX86 No NC_002945.3 Mycobrowser_v2 CDS 3434197 3435276 . + 0 Mb3136 moaA1 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1 Mb3136, moaA1, len: 359 aa. Equivalent to Rv3109,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 359 aa overlap). Probable moaA1,molybdenum cofactor biosynthesis protein, highly similar to others e.g. P39757|MOAA_BACSU|NARA|NARAB from Bacillus subtilis (341 aa), FASTA scores: opt: 810, E(): 6.2e-44,(39.75% identity in 327 aa overlap); O67929|MOAA_AQUAE|AQ_2183 from Aquifex aeolicus (320 aa),FASTA scores: opt: 794, E(): 6e-43, (40.55% identity in 323 aa overlap); Q9ZIM6|MOAA_STACA from Staphylococcus carnosus (340 aa), FASTA scores: opt: 783, E(): 3.2e-42,(38.65% identity in 326 aa overlap); etc. Also highly similar to O53143|MOAA3|MOA3_MYCTU|MT3427 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 3 from Mycobacterium tuberculosis strain F4 (378 aa), FASTA scores: opt: 1762,E(): 4.7e-104, (74.3% identity in 350 aa overlap); and similar to O53881|MOA2_MYCTU|MOAA2|Rv0869c|MT0892|MTV043.62 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 2 from Mycobacterium tuberculosis strain H37Rv (360 aa), FASTA scores: opt: 657, E(): 3e-34, (36.55% identity in 309 aa overlap). BELONGS TO THE MOAA / NIFB / PQQE FAMILY. Note that previously known as moaA. X2BNE4,Q7TX84 No NC_002945.3 Mycobrowser_v2 CDS 3435327 3435722 . + 0 Mb3137 moaB1 PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB1 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD) Mb3137, moaB1, len: 131 aa. Equivalent to Rv3110,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Probable moaB1,pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),similar to others e.g. P73790|SSL2296 from Synechocystis sp. strain PCC 6803 (96 aa), FASTA scores: opt: 195, E(): 6.2e-07, (35.4% identity in 96 aa overlap); Q9PAB4|PHS_XYLFA|XF2604 from Xylella fastidiosa (116 aa),FASTA scores: opt: 187, E(): 2.6e-06, (36.25% identity in 102 aa overlap); AAK42360|Q97WM6|PHS_SULSO|SSO2187 from Sulfolobus solfataricus (114 aa), FASTA scores: opt: 177,E(): 1.3e-05, (34.6% identity in 78 aa overlap); etc. Also highly similar to AAK47768|MT3426 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis CDC1551 (124 aa), FASTA scores: opt: 383, E(): 7.7e-20, (50.0% identity in 110 aa overlap). BELONGS TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Note that previously known as moaB. Q7TTP4 No NC_002945.3 Mycobrowser_v2 CDS 3506504 3506938 . - 0 Mb3206c HYPOTHETICAL ALANINE RICH PROTEIN Mb3206c, -, len: 144 aa. Equivalent to Rv3180c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Hypothetical unknown ala-rich protein. Contains probable coiled-coil domain from aa 40 to 70. Q7TX31 No conserved hypotheticals Rv3180c NC_002945.3 Mycobrowser_v2 CDS 3436621 3437289 . + 0 Mb3140 POSSIBLE PHOSPHATASE Mb3140, -, len: 222 aa. Equivalent to Rv3113, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 222 aa overlap). Possible phosphatase (EC 3.1.3.-), with weak similarity to other phosphatases e.g. Q9KYY0|SCE33.02c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 368, E(): 1.2e-16, (32.9% identity in 222 aa overlap); and Q55039|GPH_SYNP7|CBBZ PHOSPHOGLYCOLATE PHOSPHATASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (212 aa), FASTA scores: opt: 176, E(): 0.00025, (24.7% identity in 182 aa overlap). Q7TX83 No intermediary metabolism and respiration Rv3113 NC_002945.3 Mycobrowser_v2 CDS 3437306 3437836 . + 0 Mb3141 CONSERVED HYPOTHETICAL PROTEIN Mb3141, -, len: 176 aa. Equivalent to Rv3114, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 176 aa overlap). Conserved hypothetical protein, with some similarity to Q9F9W7 CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa), FASTA scores: opt: 207, E(): 2.2e-07, (37.05% identity in 108 aa overlap); and Q9RV23|DR1207 CELL CYCLE PROTEIN MESJ,PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN from Deinococcus radiodurans (600 aa), FASTA scores: opt: 212,E(): 3.5e-07, (33.35% identity in 177 aa overlap). Equivalent to AAK47536|MT3196 CYTIDINE AND DEOXYCYTIDYLATE DEAMINASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (187 aa) but shorter 11 aa. Q7TX82 No conserved hypotheticals Rv3114 NC_002945.3 Mycobrowser_v2 CDS 3437998 3439245 . + 0 Mb3142 PROBABLE TRANSPOSASE Mb3142, -, len: 415 aa. Equivalent to Rv3115, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 415 aa overlap). Probable IS1081 transposase, similar to others. Has transposases, mutator family, signature (PS01007). Other copies are MTCY10G2.02c, MTCY441.35, MTCY77.03c. X2BGW7,P60231 No insertion seqs and phages Rv3115 NC_002945.3 Mycobrowser_v2 CDS 3439323 3440492 . + 0 Mb3143 moeB2 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB2 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) Mb3143, moeB2, len: 389 aa. Equivalent to Rv3116,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 389 aa overlap). Probable moeB2,molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 1433, E(): 8e-80, (57.8% identity in 384 aa overlap). Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1562, E(): 1.1e-87, (58.15% identity in 380 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1311, E(): 2.1e-72, (52.4% identity in 395 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1238, E(): 5.7e-68, (51.4% identity in 393 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1212,E(): 2.2e-66, (46.5% identity in 398 aa overlap); etc. Also highly similar to O05860|MTCY07D11.20|MOEB1|Rv3206c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis strain H37Rv (392 aa), FASTA scores: opt: 1445, E(): 1.5e-80, (56.25% identity in 400 aa overlap). BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeB. Q7TX81 No NC_002945.3 Mycobrowser_v2 CDS 3456903 3458045 . + 0 Mb3160 PPE51 ppe family protein ppe51 Mb3160, PPE51, len: 380 aa. Equivalent to Rv3136,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 380 aa overlap). Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family,similar to Q9AGF0|Ov2770c Rv2770c-LIKE PROTEIN from M. microti (397 aa), FASTA scores: opt: 917, E(): 9e-41,(46.15% identity in 388 aa overlap); O33312|Rv2770c|MTV002.35c, MTV002_36, MTCI125_26,MTCY10G2_10, MTCI364_8, MTV049_28, MTV049_29, etc. TBparse score is 0.923. Q7TX66 No NC_002945.3 Mycobrowser_v2 CDS 3440521 3441483 . + 0 Mb3144 cyp141 probable cytochrome p450 141 cyp141 Mb3144, cysA3, len: 320 aa. Equivalent to 5' end of Rv3117 and 3' end of Rv3121, len: 277 aa and 400 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 255 aa overlap and 56.7% identity in 150 aa overlap). Probable cysA3, thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1442, E(): 1.7e-84, (75.55% identity in 274 aa overlap); Q9RXT9DR0217|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1046,E(): 2.6e-59, (53.8% identity in 275 aa overlap); Q9HMT7|TSSA|VNG2393G from Halobacterium sp. strain NRC-1 (293 aa), FASTA scores: opt: 1030, E(): 2.7e-58, (56.1% identity in 278 aa overlap); Q9Y8N8|APE2595 from Aeropyrum pernix (218 aa), FASTA scores: opt: 808, E(): 2.7e-44,(53.5% identity in 215 aa overlap); etc. Identical second copy present as Rv0815c|AL022004|MTV043.07c|MT0837|O05793|cysA2 (277 aa) (100.0% identity in 277 aa overlap). Also shows some similarity to P96888|THT2_MYCTU|SSEA|Rv3283|MT3382|MTCY71.23 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (297 aa), FASTA scores: opt: 955, E(): 1.6e-53, (50.2% identity in 271 aa overlap); and Q59570|THT3_MYCTU|SSEB|Rv2291|MT2348|MTCY339.19c PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (284 aa), FASTA scores: E(): 1.4e-14, (26.7% identity in 292 aa overlap). Contains rhodanese active site and C-terminal signatures (PS00380, PS00683). BELONGS TO THE RHODANESE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv. X2BMN5,Q7TX80 No NC_002945.3 Mycobrowser_v2 CDS 3443278 3444147 . + 0 Mb3147 moar1 transcriptional regulatory protein moar1 Mb3147, -, len: 289 aa. Equivalent to Rv3124, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable transcriptional regulatory protein, similar to many Streptomyces and Mycobacterium tuberculosis regulatory proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15 from Mycobacterium tuberculosis strain H37Rv (388 aa),FASTA scores: opt: 963, E(): 2e-56, (55.15% identity in 252 aa overlap); O53145 from Mycobacterium tuberculosis (381 aa); P71484|EMBR from Mycobacterium avium (384 aa),FASTA scores: opt: 859, E(): 1.5e-49, (52.2% identity in 249 aa overlap); Q9XCC3|TYLT from Streptomyces fradiae (404 aa), FASTA scores: opt: 462, E(): 3.1e-23, (35.05% identity in 254 aa overlap); Q9XCC4|TYLS from Streptomyces fradiae (277 aa), FASTA scores: opt: 456, E(): 5.6e-23,(33.45% identity in 269 aa overlap); etc. Start chosen by similarity, alternative possible (see AAK47548 from Mycobacterium tuberculosis strain CDC1551, longer N-terminus (311 aa)). Q7TX77 No regulatory proteins Rv3124 NC_002945.3 Mycobrowser_v2 CDS 3444248 3445423 . - 0 Mb3148c PPE49 ppe family protein ppe49 Mb3148c, PPE49, len: 391 aa. Equivalent to Rv3125c,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 391 aa overlap). Member of the M. tuberculosis PPE family, similar to other e.g. P95247|Rv2352c|MTCY98.21c (391 aa), FASTA scores: opt: 1576, E(): 3.8e-72, (62.55% identity in 398 aa overlap),MTCY98.0029c, MTCY03A2.22c, MTCY10G2.10, MTCY02B10.25c,MTCI364.08, M TCY21C12.09c, MTCY48.17. Q7TX76 No NC_002945.3 Mycobrowser_v2 CDS 3445919 3446953 . + 0 Mb3150 conserved protein Mb3150, -, len: 344 aa. Equivalent to Rv3127, len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 344 aa overlap). Hypothetical protein,highly similar to Mycobacterium tuberculosis protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 1212,E(): 6e-69, (56.7% identity in 321 aa overlap), and also similar to P95195|MTCY03A2.27c (332 aa), FASTA scores: opt: 521, E(): 1.6e-25; (35.0% identity in 326 aa overlap). Some similarity to C-terminal half of hypothetical Mycobacterium tuberculosis proteins. Q7TX74 No conserved hypotheticals Rv3127 NC_002945.3 Mycobrowser_v2 CDS 3458054 3458386 . - 0 Mb3160A Conserved protein Mb3160A, len: 110 aa. Equivalent to Rv3136A len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BNH3 No conserved hypotheticals Rv3136A NC_002945.3 Mycobrowser_v2 CDS 3446940 3447290 . - 0 Mb3151c CONSERVED HYPOTHETICAL PROTEIN Mb3151c, -, len: 116 aa. Equivalent to 3' end of Rv3128c, len: 337 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 116 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon but is similar throughout its length to Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 954, E(): 0, (47.2% identity in 339 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis,Rv3128c is split into 2, Mb3151c and Mb3152c. Q7TX73 No NC_002945.3 Mycobrowser_v2 CDS 3450323 3451321 . + 0 Mb3155 conserved protein Mb3155, -, len: 332 aa. Equivalent to Rv3131, len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 332 aa overlap). Hypothetical protein,similar to other hypothetical bacterial proteins e.g. O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 568,E(): 2.5e-27, (36.7% identity in 321 aa overlap); O05800|Rv3127|MTCY164.37 (344 aa), FASTA scores: opt: 521,E(): 1.9e-24, (34.95% identity in 326 aa overlap); Q9RI33|SCJ12.27c from Streptomyces coelicolor (335 aa),FASTA scores: opt: 441, E(): 1.3e-19, (35.75% identity in 319 aa overlap); Q9RI44|SCJ12.14 from Streptomyces coelicolor (309 aa), FASTA scores: opt: 328, E(): 9.3e-13,(27.9% identity in 308 aa overlap); Q9CBP5|ML1751 from Mycobacterium leprae (721 aa), FASTA scores: opt: 137,E(): 0.78, (26.15% identity in 298 aa overlap); etc. Equivalent to AAK47555 from Mycobacterium tuberculosis strain CDC1551 but shorter 12 aa. Q7TX70 No conserved hypotheticals Rv3131 NC_002945.3 Mycobrowser_v2 CDS 3451301 3453037 . - 0 Mb3156c devS TWO COMPONENT SENSOR HISTIDINE KINASE DEVS Mb3156c, devS, len: 578 aa. Equivalent to Rv3132c,len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 578 aa overlap). devS, membrane-bound two component sensor histidine kinase (EC 2.7.3.-) (see citations below; dev for Differentially Expressed in Virulent strain), similar to others two component sensors e.g. Q9RI43|SCJ12.15c PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (585 aa), FASTA scores: opt: 1305,E(): 2.5e-69, (41.35% identity in 573 aa overlap); Q9ZBY4|SCD78.15 PUTATIVE TWO COMPONENT SENSOR from Streptomyces coelicolor (560 aa), FASTA scores: opt: 1194,E(): 8.1e-63, (41.05% identity in 558 aa overlap); O85371|CPRS TWO COMPONENT REGULATOR from Rhodococcus sp (563 aa), FASTA scores: opt: 803, E(): 8.3e-40, (38.4% identity in 552 aa overlap); Q9L094|SCC24.23 PUTATIVE TWO-COMPONENT SENSOR HISTIDINE KINASE from Streptomyces coelicolor (similarity only in C-terminus for this one); etc. Also highly similar to mycobacterium O53473|Rv2027c|MTV018.14c PUTATIVE MEMBRANE PROTEIN (573 aa), FASTA scores: opt: 2333, E(): 7.6e-130, (61.45% identity in 576 aa overlap). Q7TX69 No NC_002945.3 Mycobrowser_v2 CDS 3465197 3466426 . - 0 Mb3168c PPE52 ppe family protein ppe52 Mb3168c, PPE52, len: 409 aa. Equivalent to Rv3144c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 409 aa overlap). Member of the M. tuberculosis PPE family, Gly-, Ala-rich, similar to others e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1007, E(): 5.2e-35, (56.2% identity in 306 aa overlap); and MTV014_3, MTCY6G11_5, MTCY98.0034c,MTCY31.06c, MTCY48.17, MTCY98.0029c, MTCY03C7.17c, etc. Q7TX58 No NC_002945.3 Mycobrowser_v2 CDS 3764056 3764682 . + 0 Mb3428 PROBABLE MEMBRANE PROTEIN Mb3428, -, len: 208 aa. Equivalent to Rv3395A, len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Probable membrane protein, with potential transmembrane stretches from aa 7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 107, E(): 7.4, (34.05% identity in 94 aa overlap). Q7TWJ8 No cell wall and cell processes Rv3395A NC_002945.3 Mycobrowser_v2 CDS 3453034 3453687 . - 0 Mb3157c devR TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY) Mb3157c, devR, len: 217 aa. Equivalent to Rv3133c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). devR, two component transcriptional regulator (see first citation below; dev for Differentially Expressed in Virulent strain), highly similar to several e.g. O85372|CPRR TWO COMPONENT REGULATOR from Rhodococcus sp. (212 aa), FASTA scores: opt: 868, E(): 6.2e-46, (65.05% identity in 206 aa overlap); Q9RI42|SCJ12.16c PUTATIVE LUXR FAMILY TWO-COMPONENT RESPONSE REGULATOR from Streptomyces coelicolor (233 aa), FASTA scores: opt: 849, E(): 9.7e-45,(60.55% identity in 218 aa overlap); Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 835, E(): 6.5e-44, (61.55% identity in 208 aa overlap); and similar to others. Contains bacterial regulatory proteins, LuxR family signature (PS00622) near C-terminus as seen in bvgA, comA, dctR, degU, evgA, fimZ,fixJ, gacA, glpR, narL, narP, nodW, rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. I3NIF5 No NC_002945.3 Mycobrowser_v2 CDS 3477033 3477332 . + 0 Mb3179 nuoK PROBABLE NADH DEHYDROGENASE I (CHAIN K) NUOK (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN K) Mb3179, nuoK, len: 99 aa. Equivalent to Rv3155,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Probable nuoK,integral membrane NADH dehydrogenase I, chain K (EC 1.6.5.3), similar to others e.g. Q9XAR4|NUOK from Streptomyces coelicolor (99 aa), FASTA scores: opt: 509,E(): 2.7e-31, (78.55% identity in 98 aa overlap); Q56226|NQOB_THETH|NQO11 from Thermus aquaticus (subsp. thermophilus) (95 aa), BLAST scores: initn: 298, init1: 180, bits: 85.7, FASTA scores: opt: 313, E(): 9.4e-17,(53.7% identity in 95 aa overlap); Q9RU97|DR1495 from Deinococcus radiodurans (103 aa), FASTA scores: opt: 309,E(): 2e-16, (52.0% identity in 100 aa overlap); etc. But also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES CHAIN 4L e.g. Q9MUL4|NULC_MESVI|NDHE from Mesostigma viride (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) (101 aa), FASTA scores: opt: 280, E(): 2.8e-14, (40.6% identity in 101 aa overlap); and P06261|NULC_TOBAC|NDHE|NDH4L from Nicotiana tabacum (Common tobacco) (101 aa), FASTA scores: opt: 259,E(): 1e-12, (43.0% identity in 93 aa overlap). SIMILAR TO POLYPEPTIDE 4L OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIA. X2BN81,P65566 No intermediary metabolism and respiration Rv3155 NC_002945.3 Mycobrowser_v2 CDS 3453715 3454521 . - 0 Mb3158c universal stress protein family protein Mb3158c, -, len: 268 aa. Equivalent to Rv3134c,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Conserved Ala-,Val-rich protein (see citations below), related to other hypothetical Mycobacterium tuberculosis proteins e.g. O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 562, E(): 3.2e-28, (40.65% identity in 273 aa overlap); O06188|Rv2624c|MTCY01A10.08 (272 aa), FASTA scores: opt: 458, E(): 1.1e-21, (36.55% identity in 271 aa overlap); O53472|R2026c|MTV018.13c (294 aa), FASTA scores: opt: 232,E(): 1.9e-07, (30.45% identity in 276 aa overlap); etc. Shares some similarity with other hypothetical proteins from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c (294 aa), FASTA scores: opt: 207, E(): 6.9e-06, (28.9% identity in 263 aa overlap); Q9K4L5|SC5F8.09 PUTATIVE STRESS-INDUCIBLE PROTEIN (312 aa), FASTA scores: opt: 204,E(): 1.1e-05, (28.4% identity in 271 aa overlap); etc. Equivalent to AAK47558|MT3220 Universal stress protein family from Mycobacterium tuberculosis strain CDC1551 (268 aa). Rv3134c seems cotranscribed with devR-devS (see second citation below). Q7TX68 No virulence, detoxification, adaptation Rv3134c NC_002945.3 Mycobrowser_v2 CDS 3455106 3456251 . + 0 Mb3159 PPE50 ppe family protein ppe50 Mb3159, PPE50, len: 381 aa. Similar to 5' end of Rv3135, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv, (88.5% identity in 131 aa overlap). Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to P95190|Rv3136|MTCY03A2.22c (380 aa),FASTA scores: opt: 494, E(): 6.7e-25, (57.25% identity in 131 aa overlap) (next ORF downstream), MTY21C12_9,MTCY3C7_24, MTCI125_27, MTV049_12, MTV049_9, MTV049_11 ,MTCY274_24 etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 1337 bp insertion leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Q7TX67 No NC_002945.3 Mycobrowser_v2 CDS 3458502 3459284 . + 0 Mb3161 PROBABLE MONOPHOSPHATASE Mb3161, -, len: 260 aa. Equivalent to Rv3137, len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 260 aa overlap). Probable monophosphatase (EC 3.1.3.-), equivalent to O32889|MLCB1779_19|ML0662 PUTATIVE MONOPHOSPHATASE from Mycobacterium leprae (255 aa), FASTA scores: opt: 1403,E(): 1.2e-81, (81.8% identity in 253 aa overlap). Also similar to Q9K4B1|SC7E4.05c from Streptomyces coelicolor (266 aa), FASTA scores: opt: 969, E(): 3.5e-54, (57.9% identity in 259 aa overlap); Q53743|PUR3 MONO-PHOSPHATASE from Streptomyces lipmanii (Streptomyces alboniger) (273 aa), FASTA scores: opt: 862, E(): 2.1e-47, (55.25% identity in 257 aa overlap); BAB50023|MLL3039 MONO-PHOSPHATASE from Rhizobium loti (Mesorhizobium loti) (262 aa), FASTA scores: opt: 448, E(): 3.2e-21, (31.37% identity in 255 aa overlap); etc. Contains inositol monophosphatase family signature 1 (PS00629). Q7TX65 No intermediary metabolism and respiration Rv3137 NC_002945.3 Mycobrowser_v2 CDS 3459304 3460392 . + 0 Mb3162 pflA PROBABLE PYRUVATE FORMATE LYASE ACTIVATING PROTEIN PFLA (FORMATE ACETYLTRANSFERASE ACTIVATING ENZYME) ([PYRUVATE FORMATE-LYASE] ACTIVATING ENZYME) Mb3162, pflA, len: 362 aa. Equivalent to Rv3138,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 362 aa overlap). Probable pflA,pyruvate formate lyase activating protein (EC 1.97.1.4),similar to other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa), FASTA scores: opt: 926, E(): 1.1e-52,(39.95% identity in 343 aa overlap); O27446|MTH1395 from Methanobacterium thermoautotrophicum (335 aa), FASTA scores: opt: 909, E(): 1.3e-51, (42.2% identity in 327 aa overlap); O28939|AF1330 from Archaeoglobus fulgidus (336 aa), FASTA scores: opt: 884, E(): 5.6e-50, (42.0% identity in 319 aa overlap); etc. Also similar to O50099|PH1391 HYPOTHETICAL 40.2 KDA PROTEIN from Pyrococcus horikoshii (348 aa), FASTA scores: opt: 934, E(): 3.3e-53, (40.5% identity in 343 aa overlap); and other hypothetical proteins. TBparse score is 0.881. Q7TX64 No intermediary metabolism and respiration Rv3138 NC_002945.3 Mycobrowser_v2 CDS 3460472 3461878 . + 0 Mb3163 fadE24 PROBABLE ACYL-CoA DEHYDROGENASE FADE24 Mb3163, fadE24, len: 468 aa. Equivalent to Rv3139,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable fadE24,acyl-CoA dehydrogenase (1.3.99.-), equivalent to O32890|MLCB1779.30|FADE24|ML0661 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (465 aa), FASTA scores: opt: 2587, E(): 4e-153, (83.6% identity in 464 aa overlap). Similar to other e.g. Q9HUH0|PA4995 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 1139,E(): 2.8e-63, (45.3% identity in 426 aa overlap); Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa),FASTA scores: opt: 603, E(): 4.7e-30, (30.3% identity in 366 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 601, E(): 6.3e-30,(32.25% identity in 363 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073) near C-terminus. BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.881. Q7TX63 No NC_002945.3 Mycobrowser_v2 CDS 3506941 3507393 . - 0 Mb3207c conserved protein Mb3207c, -, len: 150 aa. Equivalent to Rv3181c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 150 aa overlap). Hypothetical protein,with some similarity to other mycobacterium proteins e.g. Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c (99 aa), FASTA scores: opt: 123, E(): 0.25, (33.7% identity in 89 aa overlap); and O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 123, E(): 0.26, (39.7% identity in 68 aa overlap). Q7TX30 No conserved hypotheticals Rv3181c NC_002945.3 Mycobrowser_v2 CDS 3461899 3463104 . + 0 Mb3164 fadE23 PROBABLE ACYL-CoA DEHYDROGENASE FADE23 Mb3164, fadE23, len: 401 aa. Equivalent to Rv3140,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Probable fadE23,acyl-CoA dehydrogenase (1.3.99.-) (see citation below),equivalent to O32891|MLCB1779.31|FADE23|ML0660 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (400 aa),FASTA scores: opt: 2307, E(): 3e-136, (89.5% identity in 401 aa overlap). Also similar to others e.g. Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 1558, E(): 1.2e-89, (61.0% identity in 400 aa overlap); O31251 from Acinetobacter sp. ADP1 (401 aa), FASTA scores: opt: 1509, E(): 1.3e-86, (58.2% identity in 402 aa overlap); Q9K6D1|ACDA OR BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 612, E(): 8.4e-31, (38.2% identity in 293 aa overlap); Q9AHX9|FADFX from Pseudomonas putida (375 aa), FASTA scores: opt: 584, E(): 4.6e-29,(32.7% identity in 379 aa overlap); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.890. Q7TX62 No NC_002945.3 Mycobrowser_v2 CDS 3463204 3464175 . + 0 Mb3165 fadB4 PROBABLE NADPH QUINONE OXIDOREDUCTASE FADB4 (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN) Mb3165, fadB4, len: 323 aa. Equivalent to Rv3141,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Probable fadB4,quinone oxidoreductase (EC 1.6.5.5), showing strong similarity to variety of quinone oxidoreductases and domains in polyketide and fatty acid synthases e.g. Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35,(39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32,(40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3% identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23,(34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110 QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55% identity in 322 aa overlap); etc. Also similar to Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (325 aa), FASTA scores: opt: 673,E(): 7.2e-32, (40.2% identity in 326 aa overlap); and Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (332 aa), FASTA scores: opt: 623,E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also resembles Mycobacterium tuberculosis proteins P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03,MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. TBparse score is 0.904. Thought to be differentially expressed within host cells (see first citation below). Q7TX61 No NC_002945.3 Mycobrowser_v2 CDS 4030869 4031183 . + 0 Mb3676 PE_PGRS60 pe-pgrs family-related protein pe_pgrs60 Mb3676, PE_PGRS60, len: 104 aa. Equivalent to Rv3652, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 104 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar at N-terminal end with many e.g. P56877|Y278_MYCTU|Rv0278c|MTV035.06c (957 aa) FASTA scores: opt: 242, E(): 3e-09, (77.35% identity in 53 aa overlap). Originally annotated as the first part of a PE-PGRS family protein (Rv3653/PE_PGRS61 being the second part) but more similar to a PE family protein. Length extended since first submission (+50 aa). Q7TW11 No NC_002945.3 Mycobrowser_v2 CDS 3466791 3467177 . + 0 Mb3169 nuoA PROBABLE NADH DEHYDROGENASE I (CHAIN A) NUOA (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN A) Mb3169, nuoA, len: 128 aa. Equivalent to Rv3145,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Probable nuoA,integral membrane NADH dehydrogenase, chain A (EC 1.6.5.3), similar to others e.g. Q9XAQ4|NUOA from Streptomyces coelicolor (119 aa), FASTA scores: opt: 405,E(): 5.4e-20, (68.75% identity in 128 aa overlap); Q9RU86|DR1506 from Deinococcus radiodurans (160 aa), FASTA scores: opt: 327, E(): 9e-15, (40.3% identity in 124 aa overlap); BAB47039|NDHC from Triticum aestivum (Wheat),FASTA scores: opt: 273, E(): 2.6e-11, (38.1% identity in 126 aa overlap); etc. Also similar to a NADH-PLASTOQUINONE OXIDOREDUCTASES e.g. P26303|NU3C_WHEAT|NDHC from Triticum aestivum (Wheat) (120 aa), FASTA scores: opt: 273, E(): 2.6e-1, (38.1% identity in 126 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 3 FAMILY. TBparse score is 0.895. X2BN70,P65564 No intermediary metabolism and respiration Rv3145 NC_002945.3 Mycobrowser_v2 CDS 3467186 3467740 . + 0 Mb3170 nuoB PROBABLE NADH DEHYDROGENASE I (CHAIN B) NUOB (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN B) Mb3170, nuoB, len: 184 aa. Equivalent to Rv3146,len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Probable nuoB, NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. Q9XAQ5|NUOB from Streptomyces coelicolor (184 aa),FASTA scores: opt: 989, E(): 1.4e-56, (78.25% identity in 184 aa overlap); Q56218|NQO6_THETH|NQO6 from Thermus aquaticus (subsp. thermophilus) (181 aa), FASTA scores: opt: 720, E(): 2.6e-39, (64.45% identity in 152 aa overlap); Q9RU87|DR1505 from Deinococcus radiodurans (181 aa), FASTA scores: opt: 719, E(): 3e-39, (62.6% identity in 155 aa overlap); etc. BELONGS TO THE COMPLEX I 20 KDA SUBUNIT FAMILY. MAY CONTAIN AN IRON-SULFUR 4FE-4S CLUSTER. TBparse score is 0.912. X2BNJ1,P65576 No intermediary metabolism and respiration Rv3146 NC_002945.3 Mycobrowser_v2 CDS 3467737 3468447 . + 0 Mb3171 nuoC PROBABLE NADH DEHYDROGENASE I (CHAIN C) NUOC (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN C) Mb3171, nuoC, len: 236 aa. Equivalent to Rv3147,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Probable nuoC, NADH dehydrogenase, chain C (EC 1.6.5.3), similar to others e.g. Q9XAQ6|NUOC from Streptomyces coelicolor (251 aa),FASTA scores: opt: 1113, E(): 2.6e-64, (67.35% identity in 236 aa overlap); Q9A6X2|CC1954 from Caulobacter crescentus (197 aa), FASTA scores: opt: 351, E(): 1.6e-15, (41.65% identity in 132 aa overlap); BAB48757|MLL1369 from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 347, E(): 3e-15, (42.4% identity in 132 aa overlap); etc. Also similar to Q9UUU0|NUGM NUGM PROTEIN PRECURSOR (EC 1.6.99.3) from Yarrowia lipolytica (Candida lipolytica) (281 aa), FASTA scores: opt: 356, E(): 1.1e-15, (34.55% identity in 162 aa overlap). Also similar to MTCY251.05, FASTA score: E():4.9e-05. Equivalent to AAK47574 from Mycobacterium tuberculosis strain CDC1551 but longer 26 aa. BELONGS TO THE COMPLEX I 30 KDA SUBUNIT FAMILY. TBparse score is 0.893. X2BME6,P65572 No intermediary metabolism and respiration Rv3147 NC_002945.3 Mycobrowser_v2 CDS 3468447 3469769 . + 0 Mb3172 nuoD PROBABLE NADH DEHYDROGENASE I (CHAIN D) NUOD (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN D) Mb3172, nuoD, len: 440 aa. Equivalent to Rv3148,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable nuoD, NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa),FASTA scores: opt: 2198, E(): 1e-131, (73.9% identity in 429 aa overlap); P15689|NUCM_PARTE from Paramecium tetraurelia (400 aa), FASTA scores: opt: 922, E(): 5.8e-51, (38.5% identity in 408 aa overlap); Q9RU89|NUOD_DEIRA|DR1503 from Deinococcus radiodurans (401 aa), FASTA scores: opt: 922, E(): 5.8e-51, (47.75% identity in 404 aa overlap); etc. Equivalent to AAK47575 from Mycobacterium tuberculosis strain CDC1551 but longer 42 aa. Contains helix-turn-helix motif at aa 340-361. BELONGS TO THE COMPLEX I 49 KDA SUBUNIT FAMILY. X2BMR2,P65570 No intermediary metabolism and respiration Rv3148 NC_002945.3 Mycobrowser_v2 CDS 3469766 3470524 . + 0 Mb3173 nuoE PROBABLE NADH DEHYDROGENASE I (CHAIN E) NUOE (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN E) Mb3173, nuoE, len: 252 aa. Equivalent to Rv3149,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable nuoE, NADH dehydrogenase, chain E (EC 1.6.5.3), similar to others e.g. Q9XAQ8|NUOE from Streptomyces coelicolor (290 aa),FASTA scores: opt: 1002, E(): 5.7e-55, (69.5% identity in 213 aa overlap); P40915|NUHM_NEUCR|NUO-24 from Neurospora crassa (263 aa), FASTA scores: opt: 412, E(): 1.9e-18,(38055% identity in 192 aa overlap); P19234|NUHM_RAT from Rattus norvegicus (Rat) (241 aa), FASTA scores: opt: 410,E(): 2.4e-18, (23.9% identity in 237 aa overlap); etc. BELONGS TO THE COMPLEX I 24 KDA SUBUNIT FAMILY. BINDS A 2FE-2S CLUSTER (POTENTIAL). X2BMR1,P65574 No intermediary metabolism and respiration Rv3149 NC_002945.3 Mycobrowser_v2 CDS 3494489 3495613 . + 0 Mb3194 conserved protein Mb3194, -, len: 374 aa. Equivalent to Rv3169, len: 374 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 374 aa overlap). Conserved hypothetical protein, with similarity to other hypothetical proteins: Q9A8W6|CC1232 from Caulobacter crescentus (368 aa), FASTA scores: opt: 669, E(): 3.3e-34,(34.05% identity in 376 aa overlap); and O32901|MLCB1779.41 from Mycobacterium leprae (127 aa),FASTA scores: opt: 179, E(): 0.00034, (29.0% identity in 131 aa overlap). Also weak similarity with P95149|Rv1866|MTCY359.07c (804 aa), FASTA scores: opt: 121, E(): 6.4, (37.0% identity in 119 aa overlap). Equivalent to AAK47597 from Mycobacterium tuberculosis strain CDC1551 but shorter 43 aa. Q7TX42 No conserved hypotheticals Rv3169 NC_002945.3 Mycobrowser_v2 CDS 3470521 3471858 . + 0 Mb3174 nuoF PROBABLE NADH DEHYDROGENASE I (CHAIN F) NUOF (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN F) Mb3174, nuoF, len: 445 aa. Equivalent to Rv3150,len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Probable nuoF, NADH dehydrogenase, chain F (EC 1.6.5.3), similar to others e.g. Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449 aa), FASTA scores: opt: 2314, E(): 3.5e-139, (76.25% identity in 434 aa overlap); NUF2_RHIME from Rhizobium meliloti (421 aa), FASTA scores: opt: 1545, E(): 1.8e-90,(53.1% identity in 424 aa overlap); Q9RU92|DR1500 from Deinococcus radiodurans (444 aa), FASTA scores: opt: 1445,E(): 4.1e-84, (52.9% identity in 427 aa overlap); etc. Contains respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2 (PS00645). BELONGS TO THE COMPLEX I 51 KDA SUBUNIT FAMILY. COFACTOR: FMN AND ONE 4FE-4S CLUSTER (PROBABLE). X2BN76,P65568 No intermediary metabolism and respiration Rv3150 NC_002945.3 Mycobrowser_v2 CDS 3507624 3507968 . + 0 Mb3208 CONSERVED HYPOTHETICAL PROTEIN Mb3208, -, len: 114 aa. Equivalent to Rv3182, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Hypothetical protein,with some similarity to other hypothetical bacterial proteins e.g. O53468|Rv2022c|MTV018.09c from M. tuberculosis (201 aa), FASTA scores: opt: 335, E(): 3.6e-16, (51.9% identity in 104 aa overlap); and Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119 aa),FASTA scores: opt: 250, E(): 1.6e-10, (42.1% identity in 95 aa overlap). Equivalent to AAK47614 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but longer 20 aa. Q7TX29 No conserved hypotheticals Rv3182 NC_002945.3 Mycobrowser_v2 CDS 3471855 3474275 . + 0 Mb3175 nuoG PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G) Mb3175, nuoG, len: 806 aa. Equivalent to Rv3151,len: 806 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 806 aa overlap). Probable nuoG, NADH dehydrogenase I, chain G (EC 1.6.5.3), similar to others e.g. Q9XAR0|NUOG_STRCO from Streptomyces coelicolor (843 aa), FASTA scores: opt: 1968 ,E(): 5.2e-107, (62.45% identity in 818 aa overlap); P56914|NUG2_RHIME from Rhizobium meliloti (853 aa), FASTA scores: opt: 964, E(): 1.6e-48, (30.6% identity in 840 aa overlap); etc. But also similarity with other proteins e.g. P77908|FDHA FORMATE DEHYDROGENASE, ALPHA SUBUNIT (EC 1.2.1.43) (FORMATE DEHYDROGENASE [NADP+]) from Moorella thermoacetica (Clostridium thermoaceticum) (893 aa), FASTA scores: opt: 928, E(): 2e-46, (28.65% identity in 865 aa overlap); and Q9UUU3|NUAM NUAM PROTEIN PRECURSOR (EC 1.6.99.3) from Yarrowia lipolytica (Candida lipolytica) (728 aa), FASTA scores: opt: 894, E(): 1.7e-44, (31.95% identity in 676 aa overlap). Equivalent to AAK47578 from Mycobacterium tuberculosis strain CDC1551 but longer 15 aa. Contains respiratory-chain NADH dehydrogenase 75 kDa subunit signature 2 (PS00642). BELONGS TO THE COMPLEX I 75 KDA SUBUNIT FAMILY. COFACTOR: MAY BIND TWO 4FE-4S CLUSTER AND ONE 2FE-2S CLUSTER. TBparse score is 0.887. X2BNJ5,P59962 No intermediary metabolism and respiration Rv3151 NC_002945.3 Mycobrowser_v2 CDS 3474391 3475623 . + 0 Mb3176 nuoH PROBABLE NADH DEHYDROGENASE I (CHAIN H) NUOH (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN H) Mb3176, nuoH, len: 410 aa. Equivalent to Rv3152,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 410 aa overlap). Probable nuoH,integral membrane NADH dehydrogenase I, chain H (EC 1.6.5.3), similar to others e.g. Q9XAR1 Q9XAR1|NUOH from Streptomyces coelicolor (467 aa), FASTA scores: opt: 1630,E(): 3.4e-90, (58.35% identity in 413 aa overlap); Q9RU94|DR1498 from Deinococcus radiodurans (397 aa), FASTA scores: opt: 1081, E(): 2e-57, (45.5% identity in 391 aa overlap); Q9ZCF7|NUOH_RICPR|RP796 from Rickettsia prowazekii (339 aa), FASTA scores: opt: 976, E(): 3.4e-51,(46.2% identity in 329 aa overlap); etc. Contains respiratory-chain NADH dehydrogenase subunit 1 signature 2 (PS00668). Some similarity to MTCY251.02 (FASTA score: E(): 1.2e-07). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY. X2BME9,P65562 No intermediary metabolism and respiration Rv3152 NC_002945.3 Mycobrowser_v2 CDS 3475616 3476251 . + 0 Mb3177 nuoI PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN I) Mb3177, nuoI, len: 211 aa. Equivalent to Rv3153,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). Probable nuoI, NADH dehydrogenase I, chain I (EC 1.6.5.3), similar to others e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211 aa),FASTA scores: opt: 825, E(): 9.3e-44, (70.1% identity in 164 aa overlap); Q56224|NQO9_THETH from Thermus aquaticus (subsp. thermophilus) (182 aa), FASTA scores: opt: 543,E(): 1.8e-26, (50.9% identity in 163 aa overlap); Q9RU95|DR1497 from Deinococcus radiodurans (178 aa), FASTA scores: opt: 527, E(): 1.7e-25, (48.75% identity in 162 aa overlap); etc. Contains two 4Fe-4S ferredoxins,iron-sulfur binding region signatures (PS00198). BELONGS TO THE COMPLEX I 23 KDA SUBUNIT FAMILY. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. COFACTOR: BINDS TWO 4FE-4S CLUSTERS. X2BMR8,Q7TX57 No intermediary metabolism and respiration Rv3153 NC_002945.3 Mycobrowser_v2 CDS 3476248 3477036 . + 0 Mb3178 nuoJ PROBABLE NADH DEHYDROGENASE I (CHAIN J) NUOJ (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN J) Mb3178, nuoJ, len: 262 aa. Equivalent to Rv3154,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Probable nuoJ,transmembrane NADH dehydrogenase I, chain J (EC 1.6.5.3),similar to others e.g. Q9XAR3|NUOJ from Streptomyces coelicolor (285 aa), FASTA scores: opt: 991, E(): 3.2e-52,(63.7% identity in 243 aa overlap); Q9JX90|NUOJ|NMA0006 from Neisseria meningitidis (serogroup A) (223 aa), FASTA scores: opt: 329, E(): 9.6e-13, (34.85% identity in 175 aa overlap); Q9K1B2|NMB0253 from Neisseria meningitidis (serogroup B) (223 aa), FASTA scores: opt: 326, E(): 1.5e-12, (34.85% identity in 175 aa overlap); etc. But also similarity with Q00243|NU6C_PLEBO|NDH6 NADH-PLASTOQUINONE OXIDOREDUCTASE CHAIN 6 HOMOLOG (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) from Plectonema boryanum (199 aa),FASTA scores: opt: 287, E(): 2.8e-10, (34.35% identity in 195 aa overlap). SIMILAR TO POLYPEPTIDE 6 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIA. Q7TX56 No intermediary metabolism and respiration Rv3154 NC_002945.3 Mycobrowser_v2 CDS 3477343 3479244 . + 0 Mb3180 nuoL PROBABLE NADH DEHYDROGENASE I (CHAIN L) NUOL (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN L) Mb3180, nuoL, len: 633 aa. Equivalent to Rv3156,len: 633 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 633 aa overlap). Probable nuoL,integral membrane NADH dehydrogenase I, chain L (EC 1.6.5.3), similar to others e.g. Q9XAR5|NUOL_STRCO from Streptomyces coelicolor (654 aa), FASTA scores: opt: 2074,E(): 1.1e-111, (61.1% identity in 648 aa overlap); Q56227|NQOC_THETH|NQO12 from Thermus aquaticus (subsp. thermophilus) (606 aa), FASTA scores: opt: 1420, E(): 3.8e-74, (43.35% identity in 630 aa overlap); Q9ZJV6|NUOL|JHP1192 from Helicobacter pylori J99 (Campylobacter pylori J99) (612 aa), FASTA scores: opt: 1279, E(): 4.7e-66, (41.65% identity in 516 aa overlap); etc. Also similar to MTCY251.04 (FASTA score: E(): 1.3e-11) and MTCY03A2.01c (FASTA score: E(): 2.3e-10). SIMILAR TO POLYPEPTIDE 5 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIAL. Q7TX55 No intermediary metabolism and respiration Rv3156 NC_002945.3 Mycobrowser_v2 CDS 3479241 3480902 . + 0 Mb3181 nuoM PROBABLE NADH DEHYDROGENASE I (CHAIN M) NUOK (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN M) Mb3181, nuoM, len: 553 aa. Equivalent to Rv3157,len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 553 aa overlap). Probable nuoM,integral membrane NADH dehydrogenase I, chain M (EC 1.6.5.3), similar to others e.g. Q9XAR6|NUOM from Streptomyces coelicolor (523 aa), FASTA scores: opt: 1621,E(): 4.2e-89, (56.55% identity in 541 aa overlap); P50974|NUOM_RHOCA|NUOM from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (512 aa), FASTA scores: opt: 996, E(): 6.5e-52, (38.2% identity in 521 aa overlap); P29925|NQOD_PARDE|NQO13 from Paracoccus denitrificans (513 aa), FASTA scores: opt: 987, E(): 2.2e-51, (37.05% identity in 540 aa overlap); etc. Also similar to MTCY251.04 (FASTA score: E(): 3.3e-16) and MTCY03A2.02c (FASTA score: E(): 9.6e-13). SIMILAR TO POLYPEPTIDE 4 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIAL. Q7TX54 No intermediary metabolism and respiration Rv3157 NC_002945.3 Mycobrowser_v2 CDS 3480899 3482494 . + 0 Mb3182 nuoN PROBABLE NADH DEHYDROGENASE I (CHAIN N) NUON (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN N) Mb3182, nuoN, len: 531 aa. Equivalent to Rv3158,len: 531 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 531 aa overlap). Probable nuoN,integral membrane NADH dehydrogenase I, chain N (EC 1.6.5.3), similar to others e.g. Q9XAR7|SC10A7.08c from Streptomyces coelicolor (552 aa), FASTA scores: opt: 1493,E(): 1.1e-81, (56.7% identity in 543 aa overlap); Q9PGI2|XF0318 from Xylella fastidiosa (485 aa), FASTA scores: opt: 942, E(): 7.4e-49, (39.6% identity in 379 aa overlap); CAB51628|NUON2 from Rhizobium meliloti (Sinorhizobium meliloti) (479 aa), FASTA scores: opt: 934,E(): 2.2e-48, (35.5% identity in 479 aa overlap); etc. But also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES CHAIN 4L (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) e.g. P29801|NU2C_SYNP7|NDHB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (521 aa), FASTA scores: opt: 921, E(): 1.4e-47, (40.25% identity in 395 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 2 FAMILY. X2BMS3,P0A5M1 No intermediary metabolism and respiration Rv3158 NC_002945.3 Mycobrowser_v2 CDS 3541385 3542080 . - 0 Mb3236c conserved protein Mb3236c, -, len: 231 aa. Equivalent to Rv3210c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Conserved hypothetical protein, similar (but N-terminus shorter) to Q9FBJ1|SCP8.30 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (260 aa), FASTA scores: opt: 599,E(): 1.1e-30, (42.5% identity in 233 aa overlap); and some similarity to Q9RRV1|DR2384 PHENYLACETIC ACID DEGRADATION PROTEIN PAAC from Deinococcus radiodurans (263 aa), FASTA scores: opt: 129, E(): 0.43, (27.9% identity in 172 aa overlap); and Q9F621 FLGK PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (472 aa). Q7TX02 No conserved hypotheticals Rv3210c NC_002945.3 Mycobrowser_v2 CDS 3482500 3484269 . - 0 Mb3183c PPE53 ppe family protein ppe53 Mb3183c, PPE53, len: 589 aa. Equivalent to Rv3159c,len: 590 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 590 aa overlap). Member of the Mycobacterium tuberculosis PPE_family of Gly-, Asn-rich proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 2289, E(): 3.2e-98, (63.5% identity in 600 aa overlap); and also similar to MTCY48_17, MTV041_29, MTCY6G11_5, MTCY98_24, etc. TBparse score is 0.921. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, albeit a 2143 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7TX53 No NC_002945.3 Mycobrowser_v2 CDS 3484517 3486415 . - 0 Mb3184c PPE70 PPE FAMILY PROTEIN Mb3184c, PPE70, len: 685 aa. Equivalent to MT3248,len: 686 aa, from Mycobacterium tuberculosis strain CDC1551, (99.708% identity in 686 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an insertion of 2143 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to a additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551. Q7TX52 No NC_002945.3 Mycobrowser_v2 CDS 3486590 3487231 . - 0 Mb3185c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3185c, -, len: 213 aa. Equivalent to Rv3160c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR PROTEIN (global repressor in the nitrogen regulation system; see first citation below for more information) (222 aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity in 208 aa overlap); Q9X7X9|SC6A5.33c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (223 aa), FASTA scores: opt: 176,E(): 0.00018, (26.5% identity in 185 aa overlap); Q9XA31|SCH69.03c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (209 aa), FASTA scores: opt: 173,E(): 0.00027, (27.25% identity in 176 aa overlap); BAB54133|MLL7734 TRANSCRIPTIONAL REGULATOR from Rhizobium loti (Mesorhizobium loti) (213 aa), FASTA scores: opt: 172, E(): 0.00031, (23.55% identity in 204 aa overlap); etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis strain H37Rv e.g. P96839|Rv3557v|MTCY06G11.04c (200 aa), FASTA scores: opt: 169, E(): 0.00046, (26.75% identity in 157 aa overlap). Contains probable helix-turn-helix motif from aa 31 to 52 (Score 1857, +5.51 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.901. Q7TX51 No regulatory proteins Rv3160c NC_002945.3 Mycobrowser_v2 CDS 3487242 3488390 . - 0 Mb3186c POSSIBLE DIOXYGENASE Mb3186c, -, len: 382 aa. Equivalent to Rv3161c,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 382 aa overlap). Possible dioxygenase (EC 1.-.-.-), similar to subunit of several dioxygenases and related proteins e.g. BAB50510|MLR3662 DIOXYGENASE,ALPHA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (400 aa), FASTA scores: opt: 413, E(): 6.2e-20, (28.4% identity in 331 aa overlap); Q9A3T0|CC3122 RIESKE 2FE-2S FAMILY PROTEIN from Caulobacter crescentus (404 aa), FASTA scores: opt: 405, E(): 2.1e-19, (27.95% identity in 372 aa overlap); Q9HTF4|PA5410 PROBABLE RING HYDROXYLATING DIOXYGENASE, ALPHA-SUBUNIT from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 392, E(): 1.6e-18, (25.8% identity in 399 aa overlap); Q9AGK6|PHTAA PHTHALATE DIOXYGENASE LARGE SUBUNIT from Arthrobacter keyseri (473 aa), FASTA scores: opt: 385, E(): 5.2e-18, (34.0% identity in 206 aa overlap); P76253|YEAW_ECOLI PUTATIVE DIOXYGENASE, ALPHA SUBUNIT from Escherichia coli (374 aa),FASTA scores: opt: 376, E(): 1.7e-17, (27.05% identity in 344 aa overlap); etc. TBparse score is 0.932. Q7TX50 No intermediary metabolism and respiration Rv3161c NC_002945.3 Mycobrowser_v2 CDS 3488306 3488896 . - 0 Mb3187c POSSIBLE INTEGRAL MEMBRANE PROTEIN Mb3187c, -, len: 196 aa. Similar to 5' end of Rv3162c, len: 145 aa, from Mycobacterium tuberculosis strain H37Rv, (86.7% identity in 98 aa overlap). Possible integral membrane protein, with some similarity to C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical protein from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa overlap); and other hypothetical proteins from other organisms. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*),leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7TX49 No NC_002945.3 Mycobrowser_v2 CDS 3555400 3555618 . + 0 Mb3253 CONSERVED HYPOTHETICAL PROTEIN Mb3253, -, len: 72 aa. Equivalent to Rv3224B, len: 72 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Q7TWY7 No conserved hypotheticals Rv3224B NC_002945.3 Mycobrowser_v2 CDS 3488893 3490164 . - 0 Mb3188c POSSIBLE CONSERVED SECRETED PROTEIN Mb3188c, -, len: 423 aa. Equivalent to Rv3163c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 423 aa overlap). Possible conserved secreted protein, with some similarity to other hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from Streptomyces coelicolor (460 aa), FASTA scores: opt: 666,E(): 1.5e-33, (33.55% identity in 417 aa overlap); O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa),FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity in 389 aa overlap); etc. Also some similarity with P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium tuberculosis (317 aa), FASTA scores: opt: 198, E(): 6.3e-05, (26.75% identity in 269 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Q7TX48 No cell wall and cell processes Rv3163c NC_002945.3 Mycobrowser_v2 CDS 3490194 3491156 . - 0 Mb3189c moxR3 PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN MOXR3 Mb3189c, moxR3, len: 320 aa. Equivalent to Rv3164c,len: 320 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 320 aa overlap). Probable moxR3,methanol dehydrogenase regulatory protein, highly similar to Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa), FASTA scores: opt: 1227,E(): 1.7e-67, (60.25% identity in 302 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 1126, E(): 2.3e-61, (54.1% identity in 305 aa overlap); Q9HSH7|MOXR|VNG0223G METHANOL DEHYDROGENASE REGULATORY PROTEIN from Halobacterium sp. strain NRC-1 (318 aa), FASTA scores: opt: 1072, E(): 4.5e-58, (51.45% identity in 315 aa overlap); Q9RVV4|DR0918 MOXR-RELATED PROTEIN from Deinococcus radiodurans (354 aa), FASTA scores: opt: 1000, E(): 1.2e-53, (50.95% identity in 318 aa overlap); etc. Also high similarity with several hypothetical bacterial proteins. Q7TX47 No NC_002945.3 Mycobrowser_v2 CDS 3491164 3491646 . - 0 Mb3190c unknown protein Mb3190c, -, len: 160 aa. Equivalent to Rv3165c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein. Q7TX46 No conserved hypotheticals Rv3165c NC_002945.3 Mycobrowser_v2 CDS 3491643 3492602 . - 0 Mb3191c CONSERVED HYPOTHETICAL PROTEIN Mb3191c, -, len: 319 aa. Equivalent to Rv3166c,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 319 aa overlap). Probable transmembrane protein, similar but longer (52 aa) to O32895|MLCB1779.35c hypothetical protein from Mycobacterium leprae (119 aa), FASTA scores: opt: 289,E(): 3.7e-10, (44.25% identity in 122 aa overlap). Also some similarity to Q9Z536|SC9B2.23c PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (339 aa), FASTA scores: opt: 247, E(): 2.5e-07, (28.2% identity in 326 aa overlap); and in N-terminus to Q9RS20|DR2307 PUTATIVE MULTIDRUG-EFFLUX TRANSPORTER from Deinococcus radiodurans (410 aa), FASTA scores: opt: 135,E(): 1, (32.35% identity in 136 aa overlap). Q7TX45 No conserved hypotheticals Rv3166c NC_002945.3 Mycobrowser_v2 CDS 3492682 3493308 . - 0 Mb3192c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3192c, -, len: 208 aa. Equivalent to Rv3167c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Probable transcriptional regulator, tetR family, similar to several transcriptional regulators e.g. Q9L2A4|SC8F4.22c (TETR/ACRR FAMILY) from Streptomyces coelicolor (234 aa),FASTA scores: opt: 317, E(): 7.5e-13, (33.35% identity in 210 aa overlap); Q9RK47|SCF12.11 (TETR/ACRR FAMILY) from Streptomyces coelicolor (206 aa), FASTA scores: opt: 293,E(): 2.1e-11, (32.65% identity in 199 aa overlap); Q54288 REGULATOR OF ANTIBIOTIC TRANSPORT COMPLEXES (TETR/ACRR FAMILY) (204 aa), FASTA scores: opt: 260, E(): 2.4e-09,(30.75% identity in 205 aa overlap); etc. Equivalent to AAK47595 from Mycobacterium tuberculosis strain CDC1551 but shorter 21 aa. Contains probable helix-turn-helix motif from aa 42 to 63 (Score 1727, +5.07 SD). MAY BE BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TX44 No regulatory proteins Rv3167c NC_002945.3 Mycobrowser_v2 CDS 3493353 3494489 . + 0 Mb3193 putative aminoglycoside phosphotransferase Mb3193, -, len: 378 aa. Equivalent to Rv3168, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 378 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. Q9M7Y6|F3E22.6 from Arabidopsis thaliana (Mouse-ear cress) (314 aa), FASTA scores: opt: 236, E(): 1.1e-07, (27.35% identity in 234 aa overlap); Q9RYW2|DRA0194 from Deinococcus radiodurans (386 aa), FASTA scores: opt: 207,E(): 9.1e-06, (23.45% identity in 320 aa overlap); etc. Also some similarity with O69727|Rc3761c|MTV025.109c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (351 aa), FASTA scores: opt: 193, E(): 6.4e-05, (29.4% identity in 242 aa overlap). Q7TX43 No virulence, detoxification, adaptation Rv3168 NC_002945.3 Mycobrowser_v2 CDS 3495756 3497102 . + 0 Mb3195 aofH PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE OXIDASE) (MAO) Mb3195, aofH, len: 448 aa. Equivalent to Rv3170,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Probable aofH,flavin-containing (mono)amine oxidase (EC 1.4.3.4),similar to many eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) (522 aa), FASTA scores: opt: 869, E(): 5.3e-44, (37.7% identity in 448 aa overlap); P21396|AOFA_RAT|MAOA from Rattus norvegicus (Rat) (526 aa), FASTA scores: opt: 839, E(): 3.2e-42, (37.45% identity in 446 aa overlap); Q99NA8|MAO-A from Cavia porcellus (Guinea pig) (506 aa), FASTA scores: opt: 836,E(): 4.6e-42, (37.0% identity in 446 aa overlap); P21398|AOFA_BOVIN from Bos taurus (Bovine) (527 aa), FASTA scores: opt: 806, E(): 2.8e-40, (37.0% identity in 446 aa overlap); P21397|AOFA_HUMAN (527 aa), FASTA scores: opt: 801, E(): 5.6e-40, (37.2% identity in 446 aa overlap); etc. Alternative start possible at position 3538487. BELONGS TO THE FLAVIN MONOAMINE OXIDASE FAMILY. COFACTOR: FAD (POTENTIAL). X2BNL4,P63534 No intermediary metabolism and respiration Rv3170 NC_002945.3 Mycobrowser_v2 CDS 3497097 3497996 . - 0 Mb3196c hpx POSSIBLE NON-HEME HALOPEROXIDASE HPX Mb3196c, hpx, len: 299 aa. Equivalent to Rv3171c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 299 aa overlap). Possible hpx, non-heme haloperoxidase (EC 1.11.1.-), similar to other hydrolases (principaly epoxide hydrolases) and non-heme chloroperoxidases e.g. Q9RKB6|SCE87.22c PUTATIVE HYDROLASE from Streptomyces coelicolor (314 aa), FASTA scores: opt: 431, E(): 6e-20, (38.05% identity in 297 aa overlap); Q9HZ14|PA3226 PROBABLE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas aeruginosa (275 aa),FASTA scores: opt: 236, E(): 1e-07, (29.6% identity in 277 aa overlap); Q9DBL9|1300003 D03RIK PROTEIN SIMILAR TO ALPHA/BETA HYDROLASE FOLD from Mus musculus (Mouse) (351 aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35% identity in 304 aa overlap); AAK46260|MT1988 EPOXIDE HYDROLASE from Mycobacterium tuberculosis strain CDC1551 (356 aa), FASTA scores: opt: 223, E(): 8.4e-07, (40.7% identity in 113 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) from Streptomyces lividans (275 aa), FASTA scores: opt: 220, E(): 1e-06, (29.5% identity in 305 aa overlap); etc. Equivalent to AAK47599 Hydrolase,alpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 but shorter 24 aa. Start chosen by similarity, alternative with good RBS possible. Q7TX41 No NC_002945.3 Mycobrowser_v2 CDS 3707297 3707788 . + 0 Mb3381 PROBABLE TRANSPOSASE Mb3381, -, len: 163 aa. Equivalent to Rv3348, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Probable transposase,partially similar to several insertion elements e.g. P19834|YI11_STRCL INSERTION ELEMENT IS116 HYPOTHETICAL 44.8 KDA PROTEIN (SIMILAR TO IS900 OF MYCOBACTERIUM PARATUBERCULOSIS) from Streptomyces clavuligerus (399 aa),FASTA scores: opt: 146, E(): 0.016, (29.1% identity in 158 aa overlap). Q7TTJ5 No insertion seqs and phages Rv3348 NC_002945.3 Mycobrowser_v2 CDS 3498694 3499296 . - 0 Mb3198c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY) Mb3198c, -, len: 200 aa. Equivalent to Rv3173c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Probable transcriptional regulatory protein tetR family, similar to several bacterial putative regulatory proteins e.g. Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa),FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity in 195 aa overlap); O85695|3SCF60.04 from Streptomyces lividans and Streptomyces coelicolor (192 aa), FASTA scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa overlap); BAB50853|MLR4117 from Rhizobium loti (Mesorhizobium loti) (205 aa), FASTA scores: opt: 280,E(): 5.5e-11, (31.45% identity in 194 aa overlap); BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti) (194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05% identity in 185 aa overlap); etc. Also similar to other regulators from Mycobacterium tuberculosis e.g. P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: 154, E(): 0.0013, (38.8% identity in 80 aa overlap). Contains probable helix-turn-helix motif from aa 39 to 60 (Score 1251, +3.45 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TX39 No regulatory proteins Rv3173c NC_002945.3 Mycobrowser_v2 CDS 3499389 3500096 . + 0 Mb3199 PROBABLE SHORT-CHAIN DEHYDROGENASE/REDUCTASE Mb3199, -, len: 235 aa. Equivalent to Rv3174, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 235 aa overlap). Probable oxidoreductase short-chain dehyrogenase/reductase (EC 1.-.-.-), similar to others e.g. Q9RPT7|SITS from Streptomyces albus (223 aa), FASTA scores: opt: 654, E(): 6.1e-32, (49.3% identity in 215 aa overlap); Q9RI61|SCJ11.46 from Streptomyces coelicolor (230 aa),FASTA scores: opt: 626, E(): 2.9e-30, (50.9% identity in 224 aa overlap); Q9A5Z1|CC2306 from Caulobacter crescentus (252 aa), FASTA scores: opt: 430, E(): 1.3e-18, (39.45% identity in 228 aa overlap); Q51641 INSECT-TYPE DEHYDROGENASE (249 aa), FASTA scores: opt: 301, E(): 5.7e-11, (38.3% identity in 188 aa overlap); Q9HXC9|PA3883 from Pseudomonas aeruginosa (276 aa), FASTA scores: opt: 296, E(): 1.2e-10, (29.55% identity in 247 aa overlap); etc. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TX38 No intermediary metabolism and respiration Rv3174 NC_002945.3 Mycobrowser_v2 CDS 3620882 3622684 . + 0 Mb3313 accA3 PROBABLE BIFUNCTIONAL PROTEIN ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE (ALPHA CHAIN) ACCA3: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP) Mb3313, accA3, len: 600 aa. Equivalent to Rv3285,len: 600 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 600 aa overlap). Probable accA3,bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (EC 6.3.4.14) (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN from Mycobacterium leprae (598 aa), FASTA scores: opt: 3510,E(): 1.1e-196, (89.3% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC ACYL COENZYME A CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776,E(): 5.6e-154, (71.95% identity in 592 aa overlap); Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa), FASTA scores: opt: 2723, E(): 6.7e-151, (70.5% identity in 590 aa overlap); Q54105|BCPA BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (597 aa), FASTA scores: opt: 2721, E(): 8.9e-151, (70.05% identity in 594 aa overlap); Q9EWV4|2SCK31.20 PUTATIVE ACYL-COA CARBOXYLASE COMPLEX A SUBUNIT from Streptomyces coelicolor (590 aa), FASTA scores: opt: 2626, E(): 2.9e-145, (68.25% identity in 595 aa overlap); etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2, PS00188 Biotin-requiring enzymes attachment site. SIMILAR TO OTHER BIOTIN-DEPENDENT ENZYMES AND CARBAMOYL-PHOSPHATE SYNTHETASES. Q7TWT5 No NC_002945.3 Mycobrowser_v2 CDS 3500111 3501598 . + 0 Mb3200 POSSIBLE AMIDASE (AMINOHYDROLASE) Mb3200, -, len: 495 aa. Equivalent to Rv3175, len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Possible amidase (EC 3.5.1.-), similar to others e.g. Q9F6D0|ZHUL ENANTIOMER SELECTIVE AMIDASE from Streptomyces sp. R1128 (507 aa),FASTA scores: opt: 1328 ,E(): 7.5e-69, (44.5% identity in 492 aa overlap); BAB51815|MLR5350 PROBABLE AMIDASE from Rhizobium loti (Mesorhizobium loti) (457 aa), FASTA scores: opt: 7487, E(): 1.3e-35, (35.9% identity in 482 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC 3.5.1.4) from Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 532, E(): 3.2e-23, (32.05% identity in 471 aa overlap); etc. But also similar to glutamyl-tRNA amidotransferases who belong to amidase family e.g. Q9RTA9|DR1856 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE, SUBUNIT A from Deinococcus radiodurans (482 aa), FASTA scores: opt: 560, E(): 8.2e-25, (30.6% identity in 513 aa overlap); Q9LCX3|GATA GLU/ASP-TRNA AMIDOTRANSFERASE SUBUNIT A from Thermus aquaticus (subsp. thermophilus) (471 aa), FASTA scores: opt: 558, E(): 1.1e-24, (30.85% identity in 486 aa overlap); Q49091|GATA_MORCA GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A (EC 6.3.5.-) from Moraxella catarrhalis (492 aa), FASTA scores: opt: 526, E(): 7.5e-23, (30.45% identity in 473 aa overlap); etc. SEEMS TO BELONG TO THE AMIDASE FAMILY. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TX37 No intermediary metabolism and respiration Rv3175 NC_002945.3 Mycobrowser_v2 CDS 3527147 3528214 . - 0 Mb3225c POSSIBLE TRANSMEMBRANE CATION TRANSPORTER Mb3225c, -, len: 355 aa. Equivalent to Rv3200c,len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 355 aa overlap). Possible transmembrane cation transporter, similar to many transmembrane proteins and putative potassium channels e.g. Q9XA52|SCGD3.27C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (365 aa), FASTA scores: opt: 1022, E(): 2.6e-53, (49.85% identity in 325 aa overlap); Q9RRZ3|DR2336 PUTATIVE POTASSIUM CHANNEL from Deinococcus radiodurans (320 aa),FASTA scores: opt: 436, E(): 1e-18, (30.9% identity in 304 aa overlap); O28600|AF1673 PUTATIVE POTASSIUM CHANNEL from Archaeoglobus fulgidus (314 aa), FASTA scores: opt: 363,E(): 2.1e-14, (27.2% identity in 309 aa overlap); Q57604|Y13B_METJAMJ0138.1|MJ0138.1 PUTATIVE POTASSIUM CHANNEL from Methanococcus jannaschii (333 aa), FASTA scores: opt: 356, E(): 5.7e-14, (26.0% identity in 281 aa overlap); P73132|SLL0993 POTASSIUM CHANNEL from Synechocystis sp. strain PCC 6803 (365 aa), FASTA scores: opt: 330, E(): 2.1e-12, (27.8% identity in 324 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TX13 No cell wall and cell processes Rv3200c NC_002945.3 Mycobrowser_v2 CDS 3501595 3501912 . - 0 Mb3201c mesTb PROBABLE EPOXIDE HYDROLASE MESTB [SECOND PART] (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) Mb3201c, mesTb, len: 105 aa. Equivalent to 3' end of Rv3176c, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 105 aa overlap). Probable mesT,epoxide hydrolase (EC3.3.2.3), similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa),FASTA scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, E(): 3e-09, (29.85% identity in 288 aa overlap); O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in 278 aa overlap); etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA PROTEIN from Mycobacterium tuberculosis (288 aa),FASTA scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO PEPTIDASE FAMILY S33. Note that previously known as lipS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb. Q7TX36 No NC_002945.3 Mycobrowser_v2 CDS 3501924 3502550 . - 0 Mb3202c mesTa PROBABLE EPOXIDE HYDROLASE MESTA [FIRST PART] (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) Mb3202c, mesTa, len: 208 aa. Equivalent to 5' end of Rv3176c, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 201 aa overlap). Probable mesT, epoxide hydrolase (EC 3.3.2.3), similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa),FASTA scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, E(): 3e-09, (29.85% identity in 288 aa overlap); O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in 278 aa overlap); etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA PROTEIN from Mycobacterium tuberculosis (288 aa),FASTA scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO PEPTIDASE FAMILY S33. Note that previously known as lipS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb. Q7TX35 No NC_002945.3 Mycobrowser_v2 CDS 3502697 3503557 . + 0 Mb3203 POSSIBLE PEROXIDASE (NON-HAEM PEROXIDASE) Mb3203, -, len: 286 aa. Equivalent to Rv3177, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible peroxidase (non-haem peroxidase) (EC 1.11.1.-), highly similar to Q9KJF9|W78 CULTIVAR SPECIFICITY PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) W78 from Rhizobium leguminosarum (287 aa), FASTA scores: opt: 1059, E(): 2.3e-59, (61.4% identity in 272 aa overlap); BAB48728|MLL1328 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 746,E(): 1.1e-39, (43.25% identity in 282 aa overlap). Similar to nonheme chloroperoxidases and related esterases e.g. O73957|SAL LIPOLYTIC ENZYME from Sulfolobus acidocaldarius (314 aa), FASTA scores: opt: 408, E(): 1.9e-18, (32.4% identity in 287 aa overlap); Q9AJM9|BIOH PROTEIN INVOLVED IN BIOTIN SYNTHESIS from Kurthia sp. 538-KA26 (267 aa),FASTA scores: opt: 324 ,E(): 3.2e-13, (30.0% identity in 250 aa overlap); Q9CBB1|ML2269 PUTATIVE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (265 aa); O05691|THCF_RHOER NON-HEME HALOPEROXIDASE (EC 1.11.1.-) from Rhodococcus erythropolis (SIMILAR TO OTHER BACTERIAL NON-HEME BROMO-AND CHLORO-PEROXIDASES) (274 aa),FASTA scores: opt: 279, E(): 2.2e-10, (29.0% identity in 276 aa overlap); Q53540|EST ESTERASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas putida (276 aa), FASTA scores: opt: 271, E(): 7.1e-10, (29.65% identity in 280 aa overlap); etc. Also similar to O06420|BPOC|Rv0554|MTCY25D10.33 HYPOTHETICAL 28.3 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from M. tuberculosis (262 aa), FASTA scores: opt: 280 ,E(): 1.8e-10, (28.0% identity in 257 aa overlap). Equivalent to AAK47605 from Mycobacterium tuberculosis strain CDC1551 (300 aa) but shorter 14 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. Q7TX34 No virulence, detoxification, adaptation Rv3177 NC_002945.3 Mycobrowser_v2 CDS 3503688 3504047 . + 0 Mb3204 CONSERVED HYPOTHETICAL PROTEIN Mb3204, -, len: 119 aa. Equivalent to Rv3178, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical protein,with some similarity to other hypothetical bacterial proteins (principaly mycobacterium and streptomyces proteins) e.g. P71854|Rv3547|MTCY03C7.09c from M. tuberculosis strain H37Rv (151 aa), FASTA scores: opt: 310, E(): 2e-14, (40.5% identity in 116 aa overlap); Q9ZH81 from M. paratuberculosis (144 aa), FASTA scores: opt: 274, E(): 5.6e-12, (38.9% identity in 108 aa overlap); O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa), FASTA scores: opt: 235,E(): 2.7e-09, (35.2% identity in 108 aa overlap); Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148 aa); Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa); etc. Equivalent to AAK47606 from Mycobacterium tuberculosis strain CDC1551 (171 aa) but shorter 52 aa. Q7TX33 No conserved hypotheticals Rv3178 NC_002945.3 Mycobrowser_v2 CDS 3504868 3506157 . + 0 Mb3205 conserved protein Mb3205, -, len: 429 aa. Equivalent to Rv3179, len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Conserved hypothetical protein, highly similar to Q9KH61 PUTATIVE ATP/GTP BINDING PROTEIN from Mycobacterium smegmatis (428 aa), FASTA scores: opt: 2466, E(): 1.5e-148, (89.7% identity in 428 aa overlap) (no article found on the NCBI web site (July 2001)); and to other hypothetical bacterial proteins e.g. O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411 aa), FASTA scores: opt: 1031, E(): 8e-58, (41.5% identity in 417 aa overlap); BAB54715|MLR9349 from Rhizobium loti (Mesorhizobium loti) (435 aa), FASTA scores: opt: 365, E(): 1.1e-15, (31.75% identity in 416 aa overlap); etc. Equivalent to AAK47609 from Mycobacterium tuberculosis strain CDC1551 (454 aa) but shorter 25 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TX32 No conserved hypotheticals Rv3179 NC_002945.3 Mycobrowser_v2 CDS 3507965 3508294 . + 0 Mb3209 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb3209, -, len: 109 aa. Equivalent to Rv3183, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Possible transcriptional regulator, similar to others e.g. Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa), FASTA scores: opt: 119, E(): 0.47, (40.55% identity in 74 aa overlap); Q9X153|TM1330 from Thermotoga maritima (111 aa),FASTA scores: opt: 115, E(): 0.91, (40.35% identity in 57 aa overlap); P95258|Rv1956|MTCY09F9.08c (alias AAK46277 putative DNA-binding protein from strain CDC1551) (149 aa), FASTA scores: opt: 116, E(): 1, (42.25% identity in 71 aa overlap). Also similar to O53467|Rv2021c|MTV018.08c from Mycobacterium tuberculosis (101 aa), FASTA scores: opt: 214, E(): 5.8e-07, (43.0% identity in 107 aa overlap). Contains probable helix-turn-helix motif from aa 51 to 72 (Score 1803, +5.33 SD). Q7TX28 No regulatory proteins Rv3183 NC_002945.3 Mycobrowser_v2 CDS 3508832 3509179 . + 0 Mb3210 CONSERVED HYPOTHETICAL PROTEIN Mb3210, -, len: 115 aa. Equivalent to Rv3188, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Conserved hypothetical protein, with similarity to other proteins from Mycobacterium tuberculosis: Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 HYPOTHETICAL PROTEIN (113 aa), FASTA scores: opt: 184, E(): 8.1e-06,(28.45% identity in 109 aa overlap); and O06299|Rv0348|MTCY13E10.08 HYPOTHETICAL PROTEIN (217 aa),FASTA scores: opt: 129, E(): 0.074, (30.0% identity in 100 aa overlap). Also some similarity with C-terminus of Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 114, E(): 0.76, (30.0% identity in 110 aa overlap) (for this one, no similarity exists in the N-terminal region with the N-terminus of other regulatory components of sensory transduction systems). Q7TX27 No conserved hypotheticals Rv3188 NC_002945.3 Mycobrowser_v2 CDS 3509176 3509796 . + 0 Mb3211 CONSERVED HYPOTHETICAL PROTEIN Mb3211, -, len: 206 aa. Equivalent to Rv3189, len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Conserved hypothetical protein, weakly similar to other proteins from Mycobacterium tuberculosis e.g. O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa), FASTA scores: opt: 135, E(): 0.79, (27.8% identity in 187 aa overlap); and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186 aa),FASTA scores: opt: 122, E(): 0.85, (32.25% identity in 93 aa overlap). Q7TX26 No conserved hypotheticals Rv3189 NC_002945.3 Mycobrowser_v2 CDS 3509956 3511221 . - 0 Mb3212c HYPOTHETICAL PROTEIN Mb3212c, -, len: 421 aa. Equivalent to Rv3190c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 421 aa overlap). Hypothetical unknown protein. Q7TX25 No conserved hypotheticals Rv3190c NC_002945.3 Mycobrowser_v2 CDS 3511389 3511598 . + 0 Mb3212A Conserved protein Mb3212A, len: 69 aa. Equivalent to Rv3190A len: 69 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 69 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BMU9 No conserved hypotheticals Rv3190A NC_002945.3 Mycobrowser_v2 CDS 3511845 3512879 . - 0 Mb3213c PROBABLE TRANSPOSASE Mb3213c, -, len: 344 aa. Equivalent to Rv3191c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable transposase,similar to many especially Q9K2N8 PUTATIVE TRANSPOSASE from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 837, E(): 1.3e-43, (42.55% identity in 336 aa overlap); Q9RBF4 INSERTION SEQUENCE IS1088 from Alcaligenes eutrophus (Ralstonia eutropha) (342 aa), FASTA scores: opt: 823, E(): 9.2e-43, (43.05% identity in 337 aa overlap); and Q51379 PUTATIVE TRANSPOSASE from Pseudomonas alcaligenes (338 aa), FASTA scores: opt: 818, E(): 1.8e-42, (42.35% identity in 333 aa overlap). Contains probable helix-turn-helix motif from aa 25 to 46 (Score 1968, +5.89 SD). Q7TX24 No insertion seqs and phages Rv3191c NC_002945.3 Mycobrowser_v2 tRNA 3513905 3513978 . - 0 metU metU tRNA-Met metU, len: 74 nt. Equivalent to metU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-f-Met, anticodon cat. Described in EM_BA: MTMETA Y08623 M.tuberculosis as metA gene. Name changed to metU as metA encodes homoserine transsuccinylase.; fMet No NC_002945.3 Mycobrowser_v2 CDS 3514098 3514559 . + 0 Mb3214 CONSERVED HYPOTHETICAL ALANINE AND PROLINE-RICH PROTEIN Mb3214, -, len: 153 aa. Equivalent to Rv3192, len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Conserved hypothetical ala- and pro-rich protein, with weak similarity to N-terminal half of several proteins e.g. Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa),FASTA scores: opt: 245, E(): 3.7e-08, (33.1% identity in 157 aa overlap); O30260|AF2411 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (363 aa), FASTA scores: opt: 144, E(): 0.072, (32.6% identity in 92 aa overlap); Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa),FASTA scores: opt: 133, E(): 0.33, (25.15% identity in 159 aa overlap). Q7TX23 No conserved hypotheticals Rv3192 NC_002945.3 Mycobrowser_v2 CDS 3514729 3517707 . - 0 Mb3215c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3215c, -, len: 992 aa. Equivalent to Rv3193c,len: 992 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 992 aa overlap). Probable conserved transmembrane protein, with hydrophobic N-terminal domain (~1-340 aa), highly similar to Q9CCM6|ML0644 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (983 aa), FASTA scores: opt: 5421, E(): 0, (86.15% identity in 989 aa overlap); and O53609|Rv0064|MTV030.07 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis strain H37Rv (979 aa), FASTA scores: opt: 3204, E(): 2.1e-142,(50.25% identity in 985 aa overlap). C-terminal part (709-990 aa) highly similar to O32904|MLCB1779.46 HYPOTHETICAL 29.1 KDA PROTEIN from Mycobacterium leprae (277 aa), FASTA scores: opt: 1521, E(): 3.4e-64, (82.6% identity in 282 aa overlap). Also some similarity to hypothetical proteins generally transmembrane e.g. Q9FCI4|2SC3B6.28 from Streptomyces coelicolor (815 aa),FASTA scores: opt: 951, E(): 3.4e-37, (39.2% identity in 826 aa overlap); P72637|SLL1060 from Synechocystis sp. strain PCC 6803 (1032 aa), FASTA scores: opt: 938, E(): 1.6e-36, (29.95% identity in 855 aa overlap); O28851|AF1421 from Archaeoglobus fulgidus (880 aa), FASTA scores: opt: 526, E(): 2.6e-17, (28.05% identity in 970 aa overlap); etc. X2BMH8,Q7TX22 No cell wall and cell processes Rv3193c NC_002945.3 Mycobrowser_v2 CDS 3538342 3539199 . - 0 Mb3232c conserved protein Mb3232c, -, len: 285 aa. Equivalent to Rv3207c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Hypothetical protein,highly similar but shorter (57 aa) to Q9CCG9|ML0816 HYPOTHETICAL PROTEIN from Mycobacterium leprae (341 aa),FASTA scores: opt: 1676, E(): 9.7e-96, (81.0% identity in 284 aa overlap). Also similar to C-terminus of Q9FBI6|SCP8.36 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (559 aa), FASTA scores: opt: 426, E(): 8.4e-19,(37.35% identity in 281 aa overlap); and similar to other hypothetical proteins (generally membrane proteins) e.g. Q9K456|SC2H12.28C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (314 aa), FASTA scores: opt: 341,E(): 8.8e-14, (29.75% identity in 296 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142). Q7TX06 No conserved hypotheticals Rv3207c NC_002945.3 Mycobrowser_v2 CDS 3517799 3518821 . - 0 Mb3216c POSSIBLE CONSERVED SECRETED PROTEIN Mb3216c, -, len: 340 aa. Equivalent to Rv3194c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Possible conserved secreted protein (N-terminal stretch hydrophobic),equivalent to Q9CCM7|ML0643 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (340 aa), FASTA scores: opt: 1822,E(): 1.6e-102, (80.3% identity in 340 aa overlap). Also similar to other proteins e.g. Q9FCI6|2SC3B6.26 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (364 aa),FASTA scores: opt: 430, E(): 1.1e-18, (40.95% identity in 359 aa overlap); Q9S3Y5|SDRC SDRC PROTEIN from Streptomyces coelicolor (241 aa), FASTA scores: opt: 396,E(): 8.9e-17, (35.2% identity in 318 aa overlap) (similarity in part for this one); O34470|YLBL YLBL PROTEIN from Bacillus subtilis (350 aa), FASTA scores: opt: 385, E(): 5.6e-16, (27.7% identity in 350 aa overlap); etc. Q7TX21 No cell wall and cell processes Rv3194c NC_002945.3 Mycobrowser_v2 CDS 3518899 3520317 . + 0 Mb3217 CONSERVED HYPOTHETICAL PROTEIN Mb3217, -, len: 472 aa. Equivalent to Rv3195, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 472 aa overlap). Hypothetical protein,equivalent to Q49746|ML0642|B1937_C3_231 HYPOTHETICAL 50.3 KDA PROTEIN from Mycobacterium leprae (479 aa), FASTA scores: opt: 2503, E(): 1e-138, (79.35% identity in 475 aa overlap). Similar in part to Q9FCI9|2SC3B6.23c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (487 aa), FASTA scores: opt: 1382, E(): 2.7e-73, (46.4% identity in 489 aa overlap); Q9X8I7|SCE9.14 HYPOTHETICAL 41.2 KDA PROTEIN from Streptomyces coelicolor (375 aa),FASTA scores: opt: 319, E(): 2.4e-11, (25.6% identity in 383 aa overlap); etc. Q7TX20 No conserved hypotheticals Rv3195 NC_002945.3 Mycobrowser_v2 CDS 3520323 3521222 . + 0 Mb3218 CONSERVED HYPOTHETICAL PROTEIN Mb3218, -, len: 299 aa. Equivalent to Rv3196, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Hypothetical protein,with some similarity to other hypothetical proteins e.g. Q9FCJ5|2SC3B6.17c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (442 aa), FASTA scores: opt: 233,E(): 3.5e-07, (29.9% identity in 261 aa overlap). Q7TX19 No conserved hypotheticals Rv3196 NC_002945.3 Mycobrowser_v2 CDS 3521569 3522912 . + 0 Mb3220 PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER Mb3220, -, len: 447 aa. Equivalent to Rv3197, len: 447 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 447 aa overlap). Probable conserved ATP-binding protein ABC transporter, highly similar to Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140,(83.0% identity in 447 aa overlap). Interestingly, the N-terminal half (1-219 aa) corresponds to Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68,(88.6% identity in 219 aa overlap); and the C-terminal half (239-447 aa) corresponds to Q49745|B1937_C2_179 HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt: 1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap); two adjacent orfs from Mycobacterium leprae. Also highly similar to other proteins (generally ABC transporters) e.g. Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340,E(): 1.8e-71, (45.9% identity in 449 aa overlap); O65576|ABC1AT ABC1 PROTEIN (alias Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa overlap); O27682|MTH1645 ABC TRANSPORTER from Methanobacterium thermoautotrophicum (623 aa), FASTA scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TX17 No cell wall and cell processes Rv3197 NC_002945.3 Mycobrowser_v2 CDS 3626370 3626822 . - 0 Mb3319c lrpa probable transcriptional regulatory protein lrpa (lrp/asnc-family) Mb3319c, -, len: 150 aa. Equivalent to Rv3291c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Probable transcriptional regulator asnC-family, similar to other regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces coelicolor (165 aa), FASTA scores: opt: 503, E(): 9.1e-26,(50.35% identity in 143 aa overlap); Q9KYP0|SCD69.13 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 310,E(): 2.7e-13, (37.2% identity in 129 aa overlap); BAB50701|MLL3910 from Rhizobium loti (Mesorhizobium loti) (152 aa), FASTA scores: opt: 282, E(): 1.6e-11, (39.55% identity in 129 aa overlap); O87635|LRP_KLEAE from Klebsiella aerogenes (163 aa), FASTA scores: opt: 279,E(): 2.5e-11, (38.1% identity in 147 aa overlap); etc. Contains helix-turn-helix motif at aa 22-43 (+3.94 SD). COULD BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TWT2 No regulatory proteins Rv3291c NC_002945.3 Mycobrowser_v2 CDS 3522946 3523224 . - 0 Mb3221c whiB7 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB7 Mb3221c, whiB7, len: 92 aa. Equivalent to Rv3197A,len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Probable whiB7,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL REGULATOR WHIB7 from Mycobacterium leprae (89 aa), FASTA scores: opt: 441, E(): 6.3e-24, (69.3% identity in 88 aa overlap). Similar to Q9FCJ8|2SC3B6.14 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (122 aa), FASTA scores: opt: 348, E(): 2.2e-17, (57.7% identity in 78 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa), FASTA scores: opt: 166,E(): 7.1e-05, (39.4% identity in 76 aa overlap); etc. Q7TX16 No NC_002945.3 Mycobrowser_v2 CDS 3523654 3525756 . - 0 Mb3222c uvrD2 probable atp-dependent dna helicase ii uvrd2 Mb3222c, UvrD2, len: 700 aa. Equivalent to Rv3198c,len: 700 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 700 aa overlap). Probable UvrD2, DNA helicase II homolog (EC 3.6.1.-), equivalent to P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 PROBABLE DNA HELICASE II HOMOLOG from Mycobacterium leprae (714 aa), FASTA scores: opt: 3749, E(): 0, (82.85% identity in 706 aa overlap); and C-terminal half (466-700 aa) corresponds to Q49764|RECQ|B1937_F2_66 PUTATIVE DNA HELICASE RECQ (EC 3.6.1.-) (242 aa), FASTA scores: opt: 1267, E(): 1.4e-69, (82.5% identity in 234 aa overlap); products of two adjacent ORFS in Mycobacterium leprae. Also similar to other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces coelicolor (785 aa), FASTA scores: opt: 1687, E(): 1.2e-94, (52.05% identity in 728 aa overlap); P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in 710 aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium leprae (778 aa), FASTA scores: opt: 687, E(): 5.1e-34, (32.0% identity in 719 aa overlap); O83991|TP1028 DNA HELICASE II (UVRD) from Treponema pallidum (670 aa), FASTA scores: opt: 652, E(): 6e-32, (30.25% identity in 671 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. X2BMV8,P64321 No NC_002945.3 Mycobrowser_v2 CDS 3525880 3526134 . + 0 Mb3223 POSSIBLE GLUTAREDOXIN PROTEIN Mb3223, -, len: 84 aa. Equivalent to Rv3198A, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Possible glutaredoxin protein (EC 1.-.-.-), highly similar to Q9FCK1|2SC3B6.11c PUTATIVE GLUTAREDOXIN-LIKE PROTEIN from Streptomyces coelicolor (80 aa), FASTA scores: opt: 293, E(): 2.2e-14,(55.15% identity in 78 aa overlap); and Q9RSN9|DR2085 PUTATIVE GLUTAREDOXIN from Deinococcus radiodurans (81 aa), FASTA scores: opt: 198, E(): 1.2e-07, (53.55% identity in 56 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9X8C2|SCE36.09 HYPOTHETICAL 13.0 KDA PROTEIN from Streptomyces coelicolor (114 aa), FASTA scores: opt: 181, E(): 2.6e-06, (44.45% identity in 72 aa overlap). Q7TX15 No intermediary metabolism and respiration Rv3198A NC_002945.3 Mycobrowser_v2 CDS 3526147 3527088 . - 0 Mb3224c nudC PROBABLE NADH PYROPHOSPHATASE NUDC (NAD+ DIPHOSPHATASE) (NAD+ PYROPHOSPHATASE) (NADP PYROPHOSPHATASE) Mb3224c, nudC, len: 313 aa. Equivalent to Rv3199c,len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 313 aa overlap). Probable nudC, NADH pyrophosphatase (EC 3.6.1.22), similar in particular to Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa),FASTA scores: opt: 493, E(): 7.4e-24, (39.65% identity in 232 aa overlap); Q9ABG1|CC0266 MUTT/NUDIX FAMILY PROTEIN from Caulobacter crescentus (313 aa), FASTA scores: opt: 479, E(): 5.1e-23, (38.3% identity in 222 aa overlap); O86062|NUDC_PSEAE|NUDC|PA1823 NADH PYROPHOSPHATASE from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 371,2 E(): 3e-16, (43.15% identity in 153 aa overlap); Q9RV62|NUDC_DEIRA|NUDC|DR1168 NADH PYROPHOSPHATASE from Deinococcus radiodurans (280 aa), FASTA scores: opt: 363,E(): 9.6e-16, (34.45% identity in 270 aa overlap); etc. Caution: equivalent to AAK47636 from Mycobacterium tuberculosis strain CDC1551 (386 aa) but shorter 72 aa. Contains PS00893 mutT domain signature. BELONGS TO THE NUDIX HYDROLASE FAMILY, NUDC SUBFAMILY. COFACTOR: REQUIRES DIVALENT IONS: MANGANESE OR MAGNESIUM. X2BNP2,Q7TX14 No NC_002945.3 Mycobrowser_v2 CDS 3528276 3531581 . - 0 Mb3226c PROBABLE ATP-DEPENDENT DNA HELICASE Mb3226c, -, len: 1101 aa. Equivalent to Rv3201c,len: 1101 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1101 aa overlap). Probable ATP-dependent DNA helicase (EC 3.6.1.-), similar to others e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 aa), FASTA scores: opt: 1209, E(): 5.4e-63, (38.45% identity in 1199 aa overlap); P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 403, E(): 6.5e-16, (28.15% identity in 717 aa overlap); Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa),FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity in 1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp. (512 aa; fragment), FASTA scores: opt: 290, E(): 2e-09,(27.95% identity in 479 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TX12 No information pathways Rv3201c NC_002945.3 Mycobrowser_v2 CDS 3531578 3534745 . - 0 Mb3227c POSSIBLE ATP-DEPENDENT DNA HELICASE Mb3227c, -, len: 1055 aa. Equivalent to Rv3202c,len: 1055 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1055 aa overlap). Possible ATP-dependent DNA helicase (EC 3.6.1.-), showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 PUTATIVE ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 MISMATCH REPAIR PROTEIN MUTU (DNA HELICASE II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06,(23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar to Q9FDU2|ORF3 ORF3 PROTEIN (FRAGMENT) from Streptomyces griseus (551 aa), FASTA scores: opt: 800,E(): 1.7e-37, (36.2% identity in 525 aa overlap); and Q9ZG15 HYPOTHETICAL 35.5 KDA PROTEIN from Rhodococcus erythropolis (323 aa), FASTA scores: opt: 232, E(): 9.7e-06, (28.55% identity in 266 aa overlap). Q7TX11 No information pathways Rv3202c NC_002945.3 Mycobrowser_v2 CDS 3535071 3535856 . + 0 Mb3228 lipV POSSIBLE LIPASE LIPV Mb3228, lipV, len: 261 aa. Equivalent to alpha/beta hydrolase from Mycobacterium tuberculosis strain CDC1551 (100% identity with 260 aa overlap). Similar to Rv3203,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(86.0% identity in 224 aa overlap). Possible lipV,hydrolase lipase (EC 3.1.-.-), showing some similarity to other lipases e.g. Q9JSN0|NMA2216 PUTATIVE HYDROLASE from Neisseria meningitidis (serogroup A) (312 aa),Q9RK95|SCF1.09 PUTATIVE HYDROLASE from Streptomyces coelicolor (258 aa), Q9KZC3|SC6F7.19c PUTATIVE LIPASE from Streptomyces coelicolor (269 aa), etc. Contains serine active site signature of lipases (PS00120). Mb3228 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BNB5 No NC_002945.3 Mycobrowser_v2 CDS 3535859 3536164 . + 0 Mb3229 POSSIBLE DNA-METHYLTRANSFERASE (MODIFICATION METHYLASE) Mb3229, -, len: 101 aa. Equivalent to Rv3204, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 101 aa overlap). Possible DNA methyltransferase (EC 2.1.1.-), similar to many hypothetical bacteriel proteins and methyltransferases e.g. Q9KT40|VC1065 METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE-RELATED PROTEIN from Vibrio cholerae (100 aa), FASTA scores: opt: 170, E(): 2.8e-05, (34.35% identity in 99 aa overlap); Q9UTN9|SPAC1250.04c PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (108 aa), FASTA scores: opt: 161, E(): 0.00013,(36.65% identity in 101 aa overlap); Q9YDF4|APE0959 175 AA LONG HYPOTHETICAL METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE from Aeropyrum pernix (175 aa), FASTA scores: opt: 144, E(): 0.003, (37.95% identity in 87 aa overlap); Q50855 PUTATIVE METHYLGUANINE-DNA METHYLTRANSFERASE from Myxococcus xanthus (147 aa), FASTA scores: opt: 141, E(): 0.0041, (37.65% identity in 93 aa overlap); etc. Q7TX09 No information pathways Rv3204 NC_002945.3 Mycobrowser_v2 CDS 3542339 3543922 . + 0 Mb3237 rhlE PROBABLE ATP-DEPENDENT RNA HELICASE RHLE Mb3237, rhlE, len: 527 aa. Equivalent to Rv3211,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 527 aa overlap). Probable rhlE,ATP-dependent RNA helicase, equivalent (but shorter 22 aa) to Q9CCH3|RHLE|ML0811 PUTATIVE ATP-DEPENDENT RNA HELICASE from Mycobacterium leprae (544 aa), FASTA scores: opt: 2497, E(): 8.7e-131, (74.75% identity in 531 aa overlap). Also highly similar to other RNA helicases e.g. Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879 aa),FASTA scores: opt: 1458, E(): 3.6e-73, (52.5% identity in 522 aa overlap); Q9DF36 from Xenopus laevis (African clawed frog) (800 aa), FASTA scores: opt: 792, E(): 2.3e-36, (37.15% identity in 385 aa overlap); Q99Z38|DEAD|SPY1415 from Streptococcus pyogenes (759 aa),FASTA scores: opt: 779, E(): 1.1e-35, (37.1% identity in 380 aa overlap); P33906|DEAD|CSDA from Klebsiella pneumoniae (642 aa), FASTA scores: opt: 768, E(): 4e-35,(43.4% identity in 387 aa overlap); etc. Contains ATP/GTP-binding site motif A (PS00017) and DEAD-box subfamily ATP-dependent helicases signature (PS00039). SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND SIMILAR TO HELICASE C-TERMINAL DOMAIN. Q7TX01 No information pathways Rv3211 NC_002945.3 Mycobrowser_v2 CDS 3537076 3538251 . - 0 Mb3231c moeB1 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) Mb3231c, moeB1, len: 391 aa. Equivalent to Rv3206c,len: 392 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 392 aa overlap). Probable moeB1,molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 2285, E(): 3.3e-130, (86.45% identity in 391 aa overlap.) Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1776, E(): 1.4e-99, (65.3% identity in 395 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1526, E(): 1.5e-84, (59.1% identity in 391 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1309, E(): 1.8e-71, (52.95% identity in 387 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1308,E(): 2e-71, (50.65% identity in 397 aa overlap); etc. Also highly similar to O05792|MOEB2|Rv3116|MTCY164.26 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (389 aa), FASTA scores: opt: 1440, E(): 2.3e-79, (57.25% identity in 386 aa overlap). Has hydrophobic segment from ~45-71. BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeZ. Q7TX07 No NC_002945.3 Mycobrowser_v2 CDS 3539545 3540231 . + 0 Mb3233 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3233, -, len: 228 aa. Equivalent to Rv3208, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Probable transcriptional regulator tetR family, equivalent to Q9CCH0|ML0815 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (228 aa), FASTA scores: opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa overlap). Also highly similar to Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa), FASTA scores: opt: 629, E(): 4e-34,(45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R (FRAGMENT) from Streptomyces coelicolor A3(2) (149 aa),FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity in 147 aa overlap); Q9K3T5|SCE66.08 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (225 aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15% identity in 212 aa overlap); Q9RYK4|DRA0308 TRANSCRIPTIONAL REGULATOR, TETR FAMILY from Deinococcus radiodurans (239 aa), FASTA scores: opt: 290, E(): 6.5e-12, (30.5% identity in 223 aa overlap); etc. And also similar to Mycobacterium tuberculosis proteins P96381|Rv1019|MTCY10G2.30c HYPOTHETICAL 21.7 KDA PROTEIN (197 aa), FASTA scores: opt: 356, E(): 2.7e-16, (34.4% identity in 189 aa overlap); MTV034_4; MTY07A7A_3; MTV032_1; MTCY07A7_12; etc. Contains probable helix-turn-helix motif at aa 60-81 (Score 1517, +4.35 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TX05 No regulatory proteins Rv3208 NC_002945.3 Mycobrowser_v2 CDS 3540218 3540490 . - 0 Mb3234c TB9.4 conserved protein tb9.4 Mb3234c, TB9.4, len: 90 aa. Equivalent to Rv3208A,len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). TB9.4, conserved hypothetical protein (see citations below), equivalent to Q9CCH1|ML0814 HYPOTHETICAL PROTEIN from Mycobacterium leprae (82 aa), FASTA scores: opt: 411, E(): 1.8e-22,(81.0% identity in 79 aa overlap). Also similar, but shorter in N-terminus, to Q9FBI9|SCP8.32c PUTATIVE ATP-BINDING PROTEIN from Streptomyces coelicolor (94 aa),FASTA scores: opt: 246, E(): 8.1e-11, (53.4% identity in 73 aa overlap); Q9DGP6 (alias Q9DGP4) GLUTAMATE DECARBOXYLASE 67 KDA ISOFORM (FRAGMENT) from Alepocephalus bairdii (182 aa), FASTA scores: opt: 100, E(): 2.6, (35.3% identity in 85 aa overlap). Corresponds to Statens Serum Institute antigen, CYP10 TB9.4. Has N-terminal sequence,VEVKIGITDSPRELV. Q7TX04 No NC_002945.3 Mycobrowser_v2 CDS 3540815 3541375 . + 0 Mb3235 conserved hypothetical threonine and proline rich protein Mb3235, -, len: 186 aa. Equivalent to Rv3209, len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Conserved hypothetical thr-, pro-rich protein, equivalent (but shorter 36 aa in N-terminus) to Q9CCH2|ML0813 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (195 aa), FASTA scores: opt: 508, E(): 1.4e-15, (58.4% identity in 185 aa overlap). Also some similarity with Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from M. tuberculosis (299 aa), FASTA scores: opt: 339, E(): 3.7e-08, (35.0% identity in 180 aa overlap); and Q9CCE9|MMPS3|ML0877 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (293 aa), FASTA scores: opt: 272,E(): 2.8e-05, (36.4% identity in 173 aa overlap). Q7TX03 No conserved hypotheticals Rv3209 NC_002945.3 Mycobrowser_v2 CDS 3543935 3545158 . + 0 Mb3238 conserved alanine valine rich protein Mb3238, -, len: 407 aa. Equivalent to Rv3212, len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 407 aa overlap). Hypothetical ala-,val-rich protein, equivalent to Q9CCH4|ML0810 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (407 aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85% identity in 407 aa overlap). Weak similarity to several eukaryotic transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 TRANS-ACTING TRANSCRIPTIONAL PROTEIN from Herpes simplex virus (type 1 / strain 17) (775 aa), FASTA scores: opt: 115, E(): 2, (26.9% identity in 334 aa overlap). Q7TX00 No conserved hypotheticals Rv3212 NC_002945.3 Mycobrowser_v2 CDS 3545235 3546035 . - 0 Mb3239c POSSIBLE SOJ/PARA-RELATED PROTEIN Mb3239c, -, len: 266 aa. Equivalent to Rv3213c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(99.624% identity in 266 aa overlap). Possible soj/parA-related protein, very similar in particular to Soj/ParA proteins (and relatives) from Bacillus subtilis that inhibit the initiation of sporulation by preventing phosphorylation of Spo0A (see first citation below for more information) e.g. Q9S228|SCI51.12c from Streptomyces coelicolor (340 aa), FASTA scores: opt: 746, E(): 1.6e-40,(48.2% identity in 249 aa overlap); Q9HT11|SOJ|PA5563 from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 649,E(): 2.1e-34, (42.2% identity in 256 aa overlap); Q9PB62|XF2282 from Xylella fastidiosa (264 aa), FASTA scores: opt: 624, E(): 8.3e-33, (42.25% identity in 251 aa overlap); Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus halodurans (253 aa), FASTA scores: opt: 621, E(): 1.2e-32,(41.55% identity in 248 aa overlap); P37522|SOJ_BACSU (253 aa), FASTA scores: opt: 620, E(): 1.4e-32, (41.65% identity in 245; etc. Also similar to various mycobacterial proteins: U00021_10 from Mycobacterium leprae, MTCI125_29 from Mycobacterium tuberculosis,MLCB1351_6 from Mycobacterium leprae,MTV028_9c|Rv3918c|PARA PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium tuberculosis, MSGDNAB_18 from Mycobacterium leprae. SEEMS TO BELONG TO THE PARA FAMILY. Q7TWZ9 No cell wall and cell processes Rv3213c NC_002945.3 Mycobrowser_v2 CDS 3546189 3546800 . + 0 Mb3240 gpm2 POSSIBLE PHOSPHOGLYCERATE MUTASE GPM2 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) Mb3240, gpm2, len: 203 aa. Equivalent to Rv3214,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Possible gpm2,phosphoglycerate mutase (EC 5.4.2.1), similar to many mutases especially phosphoglycerate mutases e.g. Q9F3H5|2SCC13.14c PUTATIVE MUTASE from Streptomyces coelicolor (198 aa), FASTA scores: opt: 487, E(): 4.4e-25,(42.25% identity in 194 aa overlap); BAB49378|MLL2186 PROBABLE PHOSPHOGLYCERATE MUTASE from Rhizobium loti (Mesorhizobium loti) (193 aa), FASTA scores: opt: 423,E(): 7e-21, (41.2% identity in 182 aa overlap); Q9RKV8|SC9G1.08c PUTATIVE PHOSPHATASE from Streptomyces coelicolor (199 aa), FASTA scores: opt: 419, E(): 1.3e-20,(41.1% identity in 185 aa overlap); Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 240, E(): 8.8e-09,(36.9% identity in 168 aa overlap); Q9X194|TM1374 PHOSPHOGLYCERATE MUTASE from Thermotoga maritima (201 aa),FASTA scores: opt: 218, E(): 2.3e-07, (33.15% identity in 202 aa overlap); etc. But N-terminus also similar to Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa), FASTA scores: opt: 346,E(): 2.1e-15, (55.05% identity in 109 aa overlap). N-terminus shows also some similarity with other M. tuberculosis proteins e.g. MTCY427.09c; MTCY20G9.15; MTCY428.28. Equivalent to AAK47652 from Mycobacterium tuberculosis strain CDC1551 (228 aa) but shorter 25 aa. Note that previously known as entD. Q7TWZ8 No intermediary metabolism and respiration Rv3214 NC_002945.3 Mycobrowser_v2 CDS 3582019 3582663 . - 0 Mb3275c tmk thymidylate kinase tmk (dtmp kinase) (thymidylic acid kinase) (tmpk) Mb3275c, tmk, len: 214 aa. Equivalent to Rv3247c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable tmk,thymidylate kinase (EC 2.7.4.9), equivalent to Q9CCJ3|TMK|ML0772 PUTATIVE THYMIDYLATE KINASE from Mycobacterium leprae (210 aa), FASTA scores: opt: 1023,E(): 4.8e-57, (77.3% identity in 207 aa overlap). Also similar to other thymidylate kinases e.g. Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from Caulobacter crescentus (208 aa), FASTA scores: opt: 179, E(): 0.0003, (31.3% identity in 214 aa overlap); Q9V1E9|KTHY_PYRAB|TMK|PAB0319 from Pyrococcus abyssi (205 aa), FASTA scores: opt: 176,E(): 0.00045, (29.1% identity in 189 aa overlap); etc. BELONGS TO THE THYMIDYLATE KINASE FAMILY. Q7TWW8 No NC_002945.3 Mycobrowser_v2 CDS 3655230 3655541 . - 0 Mb3341c SECRETED PROTEIN ANTIGEN Mb3341c, -, len: 103 aa. Equivalent to Rv3312A,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Secreted protein antigen, described in Corixa patent as having N-terminal sequence YYWCPGQPFDPAWGP. Equivalent to AAK47756 from Mycobacterium tuberculosis strain CDC1551 (114 aa) but shorter 11 aa. X2BN94,Q7TWR6 No cell wall and cell processes Rv3312A NC_002945.3 Mycobrowser_v2 CDS 3546797 3547915 . + 0 Mb3241 entC PROBABLE ISOCHORISMATE SYNTHASE ENTC (ISOCHORISMATE HYDROXYMUTASE) (ENTEROCHELIN BIOSYNTHESIS) Mb3241, entC, len: 372 aa. Equivalent to Rv3215,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 372 aa overlap). Probable entC,isochorismate synthase (EC 5.4.99.6), equivalent to Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa), FASTA scores: opt: 1817,E(): 5.5e-105, (73.5% identity in 366 aa overlap). Also similar to others e.g. Q9F639|MXCD PROTEIN INVOLVED IN MYXOCHELIN-TYPE IRON CHELATOR BIOSYNTHESIS (see citation below) from Stigmatella aurantiaca (408 aa), FASTA scores: opt: 893, E(): 6.2e-48, (41.6% identity in 382 aa overlap); P45744|DHBC_BACSU ISOCHORISMATE SYNTHASE from Bacillus subtilis (398 aa), FASTA scores: opt: 883, E(): 2.5e-47, (40.45% identity in 393 aa overlap); Q9KI93|CSBC ISOCHORISMATE SYNTHASE (FRAGMENT) from Azotobacter vinelandii (361 aa), FASTA scores: opt: 794, E(): 7.6e-42,(45.65% identity in 298 aa overlap); and the two Escherichia coli proteins AAG54928|ENTC (alias BAB34055|ECS0632) ISOCHORISMATE HYDROXYMUTASE 2 from Escherichia coli strain O157:H7 (391 aa), FASTA scores: opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap); P10377|ENTC|B0593 ISOCHORISMATE SYNTHASE from Escherichia coli strain K12 (391 aa), FASTA scores: opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap); etc. Stronger similarity to Escherichia coli entC. Also similar to MTCY253.35. Q7TWZ7 No intermediary metabolism and respiration Rv3215 NC_002945.3 Mycobrowser_v2 CDS 3548063 3548395 . + 0 Mb3242 gcn5-related n-acetyltransferase, pseudogene Mb3242, -, len: 110 aa. Equivalent to Rv3216, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Possible acetyltransferase (2.3.1.-), similar but shorter to many e.g. Q9AB32|CC0402 ACETYLTRANSFERASE (GNAT FAMILY) from Caulobacter crescentus (159 aa), FASTA scores: opt: 325,E(): 3.8e-17, (45.65% identity in 103 aa overlap); P79081|ATS1 PUTATIVE ACETYLTRANSFERASE ATS1 from Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa overlap); Q9I640|PA0478 PROBABLE N-ACETYLTRANSFERASE from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 308,E(): 6.9e-16, (50.0% identity in 98 aa overlap); Q9KHE3 PUTATIVE ACETYLTRANSFERASE from Anabaena sp. strain PCC 7120 (164 aa), FASTA scores: opt: 269, E(): 5.4e-13,(41.75% identity in 103 aa overlap); etc. Also some similarity to diamine acetyltransferases (EC 2.3.1.57) e.g. Q28999|ATDA_PIG|SAT from Sus scrofa (Pig) (171 aa),FASTA scores: opt: 152, E(): 0.00025, (23.15% identity in 108 aa overlap). No intermediary metabolism and respiration Rv3216 NC_002945.3 Mycobrowser_v2 CDS 3548347 3548778 . - 0 Mb3243c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3243c, -, len: 143 aa. Equivalent to Rv3217c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Probable conserved integral membrane protein, equivalent (highly similar but shorter 30 aa) to Q9CCH6|ML0806 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (173 aa). Also similar to others e.g. Q9F3L9|2SC7G11.04 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (152 aa), FASTA scores: opt: 177, E(): 0.00024, (33.8% identity in 136 aa overlap). And shows similarity to O34238|MVIN|VC0680 VIRULENCE FACTOR MVIN HOMOLOG from Vibrio (525 aa), FASTA scores: opt: 126,E(): 0.97, (30.9% identity in 68 aa overlap). First GTG taken. Q7TWZ5 No cell wall and cell processes Rv3217c NC_002945.3 Mycobrowser_v2 CDS 3549067 3550032 . + 0 Mb3244 conserved protein Mb3244, -, len: 321 aa. Equivalent to Rv3218, len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 321 aa overlap). Conserved hypothetical protein, similar to several hypothetical bacterial proteins e.g. Q9F3M0|2SC7G11.03c from Streptomyces coelicolor (322 aa), FASTA scores: opt: 694,E(): 4.2e-35, (39.95% identity in 328 aa overlap); Q9A0J4|SPY0752 from Streptomyces pyogenes (340 aa), FASTA scores: opt: 187, E(): 0.00033, (30.5% identity in 141 aa overlap); O31502|YERQ from Bacillus subtilis (303 aa),FASTA scores: opt: 184, E(): 0.00045, (34.15% identity in 126 aa overlap); etc. Q7TWZ4 No conserved hypotheticals Rv3218 NC_002945.3 Mycobrowser_v2 CDS 3707825 3708565 . - 0 IS1561' PROBABLE TRANSPOSASE Mb3382c, -, len: 246 aa. Equivalent to Rv3349c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 PUTATIVE TRANSPOSASE from NOCARDIA ASTEROIDES (377 aa), FASTA scores: opt: 288, E(): 8.3e-11, (48.5% identity in 97 aa overlap); and others. Q7TVB5 No insertion seqs and phages Rv3349c NC_002945.3 Mycobrowser_v2 CDS 3550312 3550566 . + 0 Mb3245 whiB1 transcriptional regulatory protein whib-like whib1. contains [4fe-4s]2+ cluster. Mb3245, whiB1, len: 84 aa. Equivalent to Rv3219,len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Probable whiB1,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor. Equivalent to Q9CCH7|WHIB1|ML0804 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (84 aa), FASTA scores: opt: 580,E(): 3.5e-35, (95.25% identity in 84 aa overlap). Highly similar to several e.g. Q9X952|WBLE DEVELOPMENTAL REGULATORY PROTEIN WHIB-PARALOG from Streptomyces coelicolor (85 aa), FASTA scores: opt: 477, E(): 9.2e-28,(75.3% identity in 81 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa),FASTA scores: opt: 383, E(): 6.1e-21, (60.75% identity in 79 aa overlap); Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83 aa), FASTA scores: opt: 346, E(): 2.5e-18,(54.75% identity in 84 aa overlap); etc. Q7TWZ3 No regulatory proteins Rv3219 NC_002945.3 Mycobrowser_v2 CDS 3550628 3552133 . - 0 Mb3246c PROBABLE TWO COMPONENT SENSOR KINASE Mb3246c, -, len: 501 aa. Equivalent to Rv3220c,len: 501 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 501 aa overlap). Probable sensor (probably histidine kinase), equivalent to Q9CCH8|ML0803 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (500 aa). Similar to others e.g. Q9F3M1|2SC7G11.01 PUTATIVE HISTIDINE KINASE (FRAGMENT) from Streptomyces coelicolor (372 aa), FASTA scores: opt: 1038, E(): 7.4e-56, (48.95% identity in 380 aa overlap); Q9A3K5|CC3198 SENSOR HISTIDINE KINASE from Caulobacter crescentus (327 aa), FASTA scores: opt: 311, E(): 1.2e-11,(33.35% identity in 201 aa overlap) (similarity only in C-terminal part for this one); Q9A2T2|CC3474 PUTATIVE SENSOR HISTIDINE KINASE from Caulobacter crescentus (547 aa); etc. C-terminal half shows similarity to many sensor proteins, that respond to various stimuli from Methanobacterium thermoautotrophicum e.g. O26568|MTH468 SENSORY TRANSDUCTION HISTIDINE KINASE (554 aa), FASTA scores: opt: 425, E(): 2.1e-18, (34.0% identity in 244 aa overlap); O26546|MTH446 SENSORY TRANSDUCTION REGULATORY PROTEIN (583 aa), FASTA scores: opt: 380, E(): 1.2e-15,(37.15% identity in 202 aa overlap); O26913|MTH823 SENSORY TRANSDUCTION REGULATORY PROTEIN (677 aa), FASTA scores: opt: 375, E(): 2.7e-15, (35.4% identity in 195 aa overlap); etc. SEEMS SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES. Q7TWZ2 No regulatory proteins Rv3220c NC_002945.3 Mycobrowser_v2 CDS 3552150 3552365 . - 0 Mb3247c TB7.3 BIOTINYLATED PROTEIN TB7.3 Mb3247c, TB7.3, len: 71 aa. Equivalent to Rv3221c,len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Biotinylated protein TB7.3 (see citation below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium leprae (70 aa), FASTA scores: opt: 367, E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341, E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G BIOTIN CARBOXYLASE from Halobacterium sp. strain NRC-1 (610 aa),FASTA scores: opt: 212, E(): 4e-07, (50.0% identity in 68 aa overlap); Q58628|PYCB_METJA|MJ1231 PYRUVATE CARBOXYLASE SUBUNIT B from Methanococcus jannaschii (567 aa), FASTA scores: opt: 192, E(): 7.8e-06, (44.8% identity in 58 aa overlap); Q9ZAA7|GCDC GLUTACONYL-COA DECARBOXYLASE GAMMA SUBUNIT from Acidaminococcus fermentans (145 aa), FASTA scores: opt: 184, E(): 8.9e-06, (39.4% identity in 66 aa overlap); etc. X2BMX3 No NC_002945.3 Mycobrowser_v2 CDS 3552650 3552955 . - 0 Mb3248c rsha anti-sigma factor rsha Mb3248c, -, len: 101 aa. Equivalent to Rv3221A,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Possible anti-sigma factor, similar to Q9XCD7|AAD41811.1 unknown protein from Mycobacterium smegmatis, linked to sigma factor sigH (see first citation below) (101 aa), FASTA scores: opt: 422,E(): 3.4e-22, (64.9% identity in 94 aa overlap); and to Q9RL96|RsrA anti-sigma factor from Streptomyces coelicolor (see second citation) (105 aa), FASTA scores: opt: 163,E(): 0.00016, (32.05% identity in 78 aa overlap). Q7TWZ1 No information pathways Rv3221A NC_002945.3 Mycobrowser_v2 CDS 4251842 4252870 . - 0 Mb3873c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3873c, -, len: 342 aa. Equivalent to Rv3843c,len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 342 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CDC6|ML0073 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (344 aa), FASTA scores: opt: 1420, E(): 2.6e-68, (63.05% identity in 349 aa overlap). Q7TVJ1 No cell wall and cell processes Rv3843c NC_002945.3 Mycobrowser_v2 CDS 3990946 3991422 . - 0 Mb3635c PROBABLE CONSERVED SECRETED PROTEIN Mb3635c, -, len: 158 aa. Equivalent to Rv3605c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Probable conserved secreted or membrane protein, identical to O69527|MLCB2548.04c|ML0227 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (158 aa), FASTA scores: opt: 944,E(): 2.6e-56, (85.45% identity in 158 aa overlap). Also similar to other proteins e.g. Q9X8I2|SCE9.09 POSSIBLE SECRETED PROTEIN from Streptomyces coelicolor (162 aa),FASTA scores: opt: 174, E(): 9.2e-05, (31.25% identity in 128 aa overlap); etc. Contains possible N-terminal signal sequence. Q7TW39 No cell wall and cell processes Rv3605c NC_002945.3 Mycobrowser_v2 CDS 3552952 3553503 . - 0 Mb3249c CONSERVED HYPOTHETICAL PROTEIN Mb3249c, -, len: 183 aa. Equivalent to Rv3222c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Hypothetical protein,with some similarity to Q9SZD2|F19B15.50|AT4G29020 GLYCINE-RICH PROTEIN LIKE from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% identity in 170 aa overlap); AAK45760|MT1497.1 PE_PGRS FAMILY PROTEIN from strain CDC1551 (1408 aa), FASTA scores: opt: 137,E(): 2, (31.75% identity in 148 aa overlap); etc. Q7TWZ0 No conserved hypotheticals Rv3222c NC_002945.3 Mycobrowser_v2 CDS 3553500 3554150 . - 0 Mb3250c sigH ALTERNATIVE RNA POLYMERASE SIGMA-E FACTOR (SIGMA-24) SIGH (RPOE) Mb3250c, sigH, len: 216 aa. Equivalent to Rv3223c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). sigH (alternate gene name: rpoE), alternative RNA polymerase sigma factor (see citations below), similar to many e.g. Q9XCD8|SIGH from Mycobacterium smegmatis (215 aa), FASTA scores: opt: 1187,E(): 8.1e-69, (87.75% identity in 212 aa overlap); O87834|SIGR from Streptomyces coelicolor (227 aa), FASTA scores: opt: 913, E(): 2.6e-51, (68.8% identity in 202 aa overlap); O68520|RPOE1 from Myxococcus xanthus (213 aa),FASTA scores: opt: 452, E(): 6.7e-22, (42.8% identity in 187 aa overlap); Q06198|RPSH_PSEAE|ALGU|ALGT|PA0762 from Pseudomonas aeruginosa (193 aa), FASTA scores: opt: 301,E(): 2.7e-12, (29.9% identity in 194 aa overlap); etc. Equivalent to AAK47662 RNA polymerase sigma-70 factor from Mycobacterium tuberculosis strain CDC1551 (284 aa), but shorter 68 aa. Has sigma-70 factors ECF subfamily signature (PS01063). So BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Start chosen on basis of similarity, other potential starts upstream. X2BMK2,P66808 No NC_002945.3 Mycobrowser_v2 CDS 3554450 3555298 . + 0 Mb3251 possible iron-regulated short-chain dehydrogenase/reductase Mb3251, -, len: 282 aa. Equivalent to Rv3224, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 282 aa overlap). Probable oxidoreductase, possible short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to BAB49551|MLL2413 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053,E(): 6.4e-59, (57.95% identity in 276 aa overlap); Q9AB34|CC0400 SHORT CHAIN DEHYDROGENASE FAMILY PROTEIN from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59, (55.9% identity in 281 aa overlap); and Q9VB10|CG5590 HYPOTHETICAL PROTEIN (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Drosophila melanogaster (Fruit fly) (412 aa), FASTA scores: opt: 966, E(): 2.5e-53, (52.15% identity in 278 aa overlap). Similar to various proteins (principaly oxidoreductases) e.g. Q18639|C45B11.3 HYPOTHETICAL PROTEIN (SIMILAR TO THE SDR FAMILY) from Caenorhabditis elegans (293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3% identity in 271 aa overlap); Q9HZV5|PA2892 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (274 aa), FASTA scores: opt: 847, E(): 5.1e-46, (49.25% identity in 274 aa overlap); Q9I6V0|PA0182 PROBABLE SHORT-CHAIN DEHYDROGENASE (SIMILAR TO THE SDR FAMILY) from Pseudomonas aeruginosa (250 aa), FASTA scores: opt: 333,E(): 8.3e-14, (29.8% identity in 245 aa overlap); Q9HY98|PA3511 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (253 aa), FASTA scores: opt: 330,E(): 1.3e-13, (31.2% identity in 250 aa overlap); etc. Related proteins in Mycobacterium tuberculosis include MTCY02B10.14, MTCY369.14, and MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017) near C-terminus. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TWY9 No intermediary metabolism and respiration Rv3224 NC_002945.3 Mycobrowser_v2 CDS 3555234 3555422 . + 0 Mb3252 CONSERVED HYPOTHETICAL PROTEIN Mb3252, -, len: 62 aa. Equivalent to Rv3224A, len: 62 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 62 aa overlap). Conserved hypothetical protein (possibly gene fragment), overlaps Rv3224. Similar to N-terminus of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa),FASTA scores: opt: 104, E(): 0.78, (59.37% identity in 32 aa overlap). Note that upstream ORF Rv3224B is similar to C-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Q7TWY8 No conserved hypotheticals Rv3224A NC_002945.3 Mycobrowser_v2 CDS 3555615 3557039 . - 0 Mb3254c gcn5-related n-acetyltransferase, phosphorylase Mb3254c, -, len: 474 aa. Equivalent to Rv3225c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 474 aa overlap). Possible transferase (EC 2.-.-.-). C-terminal part shows some similarity to various bacterial proteins e.g. BAB49093|MLL1809 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (298 aa), FASTA scores: opt: 557, E(): 2.8e-26,(34.55% identity in 295 aa overlap); P14509|KKA8_ECOLI|APHA AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Escherichia coli (271 aa),FASTA scores: opt: 194, E(): 0.00018, (27.75% identity in 227 aa overlap); Q53826|CPH CAPREOMYCIN PHOSPHOTRANSFERASE from Streptomyces capreolus (281 aa), FASTA scores: opt: 178, E(): 0.0017, (30.5% identity in 269 aa overlap); Q9CDM4|YWIA UNKNOWN PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (213 aa), FASTA scores: opt: 167, E(): 0.0061, (2705% identity in 149 aa overlap); Q9X843|SC9B1.24 PUTATIVE TRANSFERASE (FRAGMENT) from Streptomyces coelicolor (317 aa), FASTA scores: opt: 165, E(): 0.011, (26.05% identity in 280 aa overlap); etc. Start uncertain. Q7TWY6 No intermediary metabolism and respiration Rv3225c NC_002945.3 Mycobrowser_v2 CDS 3594025 3594444 . + 0 Mb3287 CONSERVED HYPOTHETICAL PROTEIN Mb3287, -, len: 139 aa. Equivalent to Rv3259, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, equivalent, but shorter 29 aa, to Q9CCJ9|ML0761 HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FASTA scores: opt: 846, E(): 2.2e-47,(89.2% identity in 139 aa overlap). C-terminus highly similar to Q9S425 HYPOTHETICAL 6.0 KDA PROTEIN (FRAGMENT) from Mycobacterium smegmatis (54 aa), FASTA scores: opt: 275, E(): 2.7e-11, (81.15% identity in 53 aa overlap). Also similar to Q9KZL3|SCE34.12 from Streptomyces coelicolor (117 aa), FASTA scores: opt: 152, E(): 0.004,(34.15% identity in 126 aa overlap). Equivalent to AAK47699 from Mycobacterium tuberculosis strain CDC1551 (175 aa) but shorter 36 aa. Q7TWV6 No conserved hypotheticals Rv3259 NC_002945.3 Mycobrowser_v2 CDS 3557163 3557921 . - 0 Mb3255c CONSERVED HYPOTHETICAL PROTEIN Mb3255c, -, len: 252 aa. Equivalent to Rv3226c,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Conserved hypothetical protein, similar to various hypothetical bacterial proteins e.g. Q9CCI2|ML0793 PUTATIVE BACTERIOPHAGE PROTEIN from Mycobacterium leprae (252 aa),FASTA scores: opt: 1183, E(): 3.8e-68, (70.65% identity in 252 aa overlap); BAB54183|MLR7795 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (369 aa), FASTA scores: opt: 417, E(): 2.9e-19, (33.75% identity in 252 aa overlap); O64131 YOQW PROTEIN from Bacteriophage SPBc2 (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O31916 YOQW PROTEIN from Bacillus subtilis (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O34906 YOAM PROTEIN from Bacillus subtilis (227 aa), FASTA scores: opt: 401, E(): 2e-18, (37.7% identity in 244 aa overlap); Q9K4A5|SC7E4.11 HYPOTHETICAL 30.8 KDA PROTEIN from Streptomyces coelicolor (271 aa), FASTA scores: opt: 383,E(): 3.3e-17, (39.6% identity in 283 aa overlap); etc. Q7TWY5 No conserved hypotheticals Rv3226c NC_002945.3 Mycobrowser_v2 CDS 3563469 3564356 . - 0 Mb3261c ppk2 polyphosphate kinase ppk2 (polyphosphoric acid kinase) Mb3261c, pvdS, len: 295 aa. Equivalent to Rv3232c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Possible pvdS, an alternative RNA polymerase sigma factor, highly similar (but N-terminus longer 25-50 residues approximatively) to Q9RIZ9|SCJ1.15 PUTATIVE REGULATOR from Streptomyces coelicolor (267 aa), FASTA scores: opt: 1189, E(): 1.4e-70, (65.65% identity in 262 aa overlap); Q9KU02|VC0728 HYPOTHETICAL PROTEIN from Vibrio cholerae (258 aa), FASTA scores: opt: 1074, E(): 4.5e-63, (62.6% identity in 254 aa overlap); P72119|PVDS PAO SUBSTRAIN OT684 PYOVERDINE GENE TRANSCRIPTIONAL REGULATOR PVDS (FRAGMENT) from Pseudomonas aeruginosa (see citation below) (237 aa), FASTA scores: opt: 988, E(): 1.8e-57,(60.8% identity in 227 aa overlap). Also highly similar to Q9I154|PA2428 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (304 aa), FASTA scores: opt: 1057, E(): 6.8e-62, (60.7% identity in 252 aa overlap); Q9I6Z1|PA0141 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (298 aa),FASTA scores: opt: 990, E(): 1.6e-57, (54.6% identity in 249 aa overlap); and other hypothetical bacterial proteins. Could be a member of a subfamily of RNA polymerase sigma factors which direct the synthesis of extracellular products by bacteria. Start uncertain. Q7TWX9 No NC_002945.3 Mycobrowser_v2 CDS 3769576 3770364 . + 0 Mb3433 PROBABLE HYDROLASE Mb3433, -, len: 262 aa. Equivalent to Rv3400, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Probable hydrolase (EC 3.-.-.-), strongly equivalent to Q49741|YY00_MYCLE|ML0393|B1620_F3_119 HYPOTHETICAL 28.6 KDA PROTEIN from Mycobacterium leprae (261 aa), FASTA scores: opt: 1293, E(): 2.2e-71, (74.45% identity in 262 aa overlap). Similar to several various proteins (notably hydrolases) e.g. Q9L2I7|SCF42.32 PUTATIVE HYDROLASE from Streptomyces coelicolor (246 aa), FASTA scores: opt: 888,E(): 7.7e-47, (56.35% identity in 245 aa overlap); Q9EX06|2SCG38.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (238 aa), FASTA scores: opt: 195, E(): 8.1e-05,(29.5% identity in 234 aa overlap); Q9I5X4|PA0562 PROBABLE HYDROLASE from Pseudomonas aeruginosa (224 aa), FASTA scores: opt: 190, E(): 0.00015, (27.8% identity in 248 aa overlap); O06995|PGMB_BACSU|YVDM PUTATIVE BETA-PHOSPHOGLUCOMUTASE from Bacillus subtilis (226 aa),FASTA scores: opt: 190, E(): 0.00016, (33.9% identity in 245 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),FASTA scores: opt: 413, E(): 2e-17, (34.9% identity in 238 aa overlap). Interestingly, note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle. X2BNW1,P65070 No intermediary metabolism and respiration Rv3400 NC_002945.3 Mycobrowser_v2 CDS 3557976 3559328 . + 0 Mb3256 aroA 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE AROA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS) Mb3256, aroA, len: 450 aa. Equivalent to Rv3227,len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 450 aa overlap). aroA,3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19) (see citation below), equivalent (but C-terminus longer) to Q9CCI3|AROA|ML0792 PUTATIVE 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYL TRANSFERASE from Mycobacterium leprae (430 aa), FASTA scores: opt: 1466, E(): 1.4e-78, (55.05% identity in 427 aa overlap). Contains PS00885 EPSP synthase signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY. X2BMZ8,Q7TWY4 No intermediary metabolism and respiration Rv3227 NC_002945.3 Mycobrowser_v2 CDS 3559325 3560317 . + 0 Mb3257 CONSERVED HYPOTHETICAL PROTEIN Mb3257, -, len: 330 aa. Equivalent to Rv3228, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Conserved hypothetical protein, equivalent to Q9CCI4|ML0791 HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa),FASTA scores: opt: 1828, E(): 1e-98, (84.0% identity in 331 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces coelicolor (337 aa), FASTA scores: opt: 1051, E(): 1e-53,(52.65% identity in 338 aa overlap); Q9HUL3|PA4952 from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 392 ,E(): 1.4e-15, (34.85% identity in 281 aa overlap); Q9PFV1|XF0556 from Xylella fastidiosa (341 aa), FASTA scores: opt: 367, E(): 4e-14, (36.85% identity in 247 aa overlap); P45339|YJEQ_HAEIN|HI1714 from Haemophilus influenzae (346 aa), FASTA scores: opt: 355, E(): 2e-13,(31.65% identity in 281 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A. Q7TWY3 No conserved hypotheticals Rv3228 NC_002945.3 Mycobrowser_v2 CDS 3560350 3561633 . - 0 Mb3258c desa3 POSSIBLE LINOLEOYL-COA DESATURASE (DELTA(6)-DESATURASE) Mb3258c, -, len: 427 aa. Equivalent to Rv3229c,len: 427 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 427 aa overlap). Possible linoleoyl-CoA desaturase (EC 1.14.19.3), showing similarity with desaturases and other proteins e.g. Q08871|DES6|SLL0262 LINOLEOYL-COA DESATURASE from Synechocystis sp. strain PCC 6803 (359 aa), FASTA scores: opt: 319, E(): 4e-13, (25.1% identity in 295 aa overlap); Q54795|DESD DELTA 6 DESATURASE from Spirulina platensis (368 aa), FASTA scores: opt: 268, E(): 7.7e-10, (25.0% identity in 300 aa overlap); Q9ZTU8|S276 PROTEIN WITH SIMILARITY TO CYTOCHROME B5 DOMAIN from Triticum aestivum (Wheat) (469 aa), FASTA scores: opt: 240, E(): 5.9e-08,(27.05% identity in 266 aa overlap); etc. Note that previously known as desA3. Q7TWY2 No lipid metabolism Rv3229c NC_002945.3 Mycobrowser_v2 CDS 3561711 3562853 . - 0 Mb3259c HYPOTHETICAL OXIDOREDUCTASE Mb3259c, -, len: 380 aa. Equivalent to Rv3230c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Putative oxidoreductase (EC 1.-.-.-), with some similarity to various proteins, especially reductases e.g. Q9HUS4|PA4889 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (366 aa), FASTA scores: opt: 516, E(): 1.8e-24, (33.8% identity in 367 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from Pseudomonas putida (337 aa), FASTA scores: opt: 380,E(): 4e-16, (30.7% identity in 277 aa overlap); BAB34381|ECS0958 NADH OXIDOREDUCTASE FOR THE HCP from Escherichia coli strain O157:H7 (322 aa), FASTA scores: opt: 369, E(): 1.8e-15, (28.65% identity in 328 aa overlap); Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter sp. (336 aa), FASTA scores: opt: 305, E(): 1.6e-11, (27.4% identity in 303 aa overlap); etc. Q7TWY1 No intermediary metabolism and respiration Rv3230c NC_002945.3 Mycobrowser_v2 CDS 3562963 3563472 . - 0 Mb3260c conserved protein Mb3260c, -, len: 169 aa. Equivalent to Rv3231c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Hypothetical protein,only similar to Q9KYX9|SCE33.03c HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap). Q7TWY0 No conserved hypotheticals Rv3231c NC_002945.3 Mycobrowser_v2 CDS 3564380 3565789 . - 0 Mb3262c tgs3 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb3262c, -, len: 469 aa. Equivalent to Rv3234c and Rv3233c, len: 271 aa and 196 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 266 aa overlap and 100.0% identity in 196 aa overlap). Rv3234c: Hypothetical protein, similar to C-terminus of Mycobacterium tuberculosis hypothetical proteins e.g. P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26; MTV013_8; MTY13E12_33; etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 309,E(): 4.3e-12, (33.35% identity in 189 aa overlap). Rv3233c: Hypothetical protein, similar to C-terminus of Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 308,E(): 1.2e-12, (32.0% identity in 200 aa overlap); and several hypothetical Mycobacterium tuberculosis proteins e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa),FASTA scores: opt: 248, E(): 9.8e-09, (27.5% identity in 200 aa overlap); MTCY28_26; MTCY493_29; MTCY31_25; MTCY31_25. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-g) leads to a single product that is more similar to Rv3234c. Q7TWX8 No lipid metabolism Rv3234c NC_002945.3 Mycobrowser_v2 CDS 3566559 3567716 . - 0 Mb3264c PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Mb3264c, -, len: 385 aa. Equivalent to Rv3236c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Probable conserved integral membrane transport protein, possibly cation (Na/H) transporter, equivalent to Q9CCI5|ML0782 putative transmembrane transport protein from Mycobacterium leprae (385 aa), FASTA scores: opt: 1975, E(): 2.4e-108, (81.55% identity in 385 aa overlap). Highly similar to others e.g. O69958|SC4H2.03c putative transmembrane transport protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 1226, E(): 1.6e-64, (53.5% identity in 372 aa overlap); Q9XAKO|SC66T3.13c putative transmembrane transport protein from Streptomyces coelicolor (403 aa), FASTA scores: opt: 1198, E(): 6.8e-63, (53.25% identity in 370 aa overlap); Q9RV80|DR1149 putative Na+/H+ antiporter from Deinococcus radiodurans (383 aa), FASTA scores: opt: 1069, E(): 2.3e-55, (47.35% identity in 376 aa overlap); Q9L191|SC10G8.11 putative transmembrane transport protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 695, E(): 1.9e-33, (38.05% identity in 384 aa overlap); Q9RRW8|DR2367 putative glutathione-regulated potassium-efflux system protein KEFB from Deinococcus radiodurans (575 aa), FASTA scores: opt: 414, E(): 6.2e-17, (30.25% identity in 380 aa overlap); etc. SEEMS TO BELONG TO THE CPA2 FAMILY. Note that previously known as kefB. Q7TWX6 No cell wall and cell processes Rv3236c NC_002945.3 Mycobrowser_v2 CDS 3567721 3568203 . - 0 Mb3265c conserved protein Mb3265c, -, len: 160 aa. Equivalent to Rv3237c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Conserved hypothetical protein, equivalent to Q9CCI6|ML0781 HYPOTHETICAL PROTEIN from Mycobacterium leprae (160 aa),FASTA scores: opt: 828, E(): 1.5e-45, (80.6% identity in 160 aa overlap); and similar to other hypothetical bacterial proteins and more weakly to putative potassium channels e.g. Q9RV81|DR1148 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (175 aa), FASTA scores: opt: 420, E(): 9.5e-20, (37.95% identity in 158 aa overlap); O69959|SC4H2.04c HYPOTHETICAL 17.1 KDA PROTEIN from Streptomyces coelicolor (161 aa), FASTA scores: opt: 315,E(): 3.8e-13, (40.0% identity in 150 aa overlap); Q9HNH3|PCHB|VNG2104G POTASSIUM CHANNEL HOMOLOG from Halobacterium sp. strain NRC-1 (418 aa), FASTA scores: opt: 158, E(): 0.007, (31.45% identity in 124 aa overlap); Q58752|YD57_METJA|MJ1357 PUTATIVE POTASSIUM CHANNEL PROTEIN from Methanococcus jannaschii (343 aa), FASTA scores: opt: 143, E(): 0.053, (33.8% identity in 68 aa overlap). Q7TWX5 No conserved hypotheticals Rv3237c NC_002945.3 Mycobrowser_v2 CDS 3568264 3568998 . - 0 Mb3266c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3266c, -, len: 244 aa. Equivalent to Rv3238c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable conserved integral membrane protein, similar to several hypothetical proteins and transmembrane proteins e.g. Q9UN92|NRM29 MULTISPANNING NUCLEAR ENVELOPE MEMBRANE PROTEIN NURIM (FRAGMENT) from Homo sapiens (Human) (261 aa), FASTA scores: opt: 281, E(): 3.3e-11, (30.7% identity in 189 aa overlap); Q9VEG9|CG7655 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (253 aa), FASTA scores: opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa overlap); BAB48937|MLR1600 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (222 aa), FASTA scores: opt: 137, E(): 0.066, (28.1% identity in 185 aa overlap); BAB57936|SAV1774 AESENICAL PUMP MEMBRANE PROTEIN HOMOLOG from Staphylococcus aureus subsp. aureus Mu50 (430 aa), FASTA scores: opt: 125, E(): 0.68, (25.7% identity in 144 aa overlap); etc. Q7TWX4 No cell wall and cell processes Rv3238c NC_002945.3 Mycobrowser_v2 CDS 3569057 3572203 . - 0 Mb3267c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN Mb3267c, -, len: 1048 aa. Equivalent to Rv3239c,len: 1048 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1048 aa overlap). Probable conserved transmembrane protein, organised in two domains. Domain comprising first ~500 aa residues is similar to various antibiotic resistance and efflux proteins and contains sugar transport proteins signature 1 (PS00216); e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 905, E(): 3.1e-41, (36.95% identity in 482 aa overlap); and O68912|FRNF PUTATIVE ANTIBIOTIC ANTIPORTER from Streptomyces roseofulvus (517 aa), FASTA scores: opt: 866, E(): 4.1e-39, (37.1% identity in 512 aa overlap). Second part, corresponding to last 550 aa residues, is very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kd protein from Mycobacterium tuberculosis (583 aa),FASTA scores: E(): 2.1e-28, (36.5% identity in 572 aa overlap). Also equivalent to Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN (SIMILAR TO SUGAR TRANSPORTER FAMILY) from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 4328, E(): 0, (64.15% identity in 1046 aa overlap); and similar to other Mycobacterium tuberculosis proteins: MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E(): 6.3e-32; MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E(): 2.5e-26. Equivalent to AAK47679 Drug transporter from Mycobacterium tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa. Contains cyclic nucleotide-binding domain signature 2 (PS00889). Probably member of major facilitator superfamily (MFS). Q7TWX3 No cell wall and cell processes Rv3239c NC_002945.3 Mycobrowser_v2 CDS 3572282 3575131 . - 0 Mb3268c secA1 PROBABLE PREPROTEIN TRANSLOCASE SECA1 1 SUBUNIT Mb3268c, secA1, len: 949 aa. Equivalent to Rv3240c,len: 949 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 949 aa overlap). Probable secA1,preprotein translocase subunit, component of secretion apparatus, highly similar to many e.g. P57996|SEA1_MYCLE from Mycobacterium leprae (940 aa), FASTA scores: opt: 5044, E(): 0, (87.5% identity in 849 aa overlap); P95759|SECA_STRGR from Streptomyces griseus (940 aa),FASTA scores: opt: 2612, E(): 1.9e-134, (61.35% identity in 960 aa overlap); P28366|SECA_BACSU|DIV+ from Bacillus subtilis (841 aa), FASTA scores: opt: 1776, E(): 4.9e-89,(48.05% identity in 837 aa overlap); etc. BELONGS TO THE SECA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA, SECD|Rv2587c, SECE|Rv0638,SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Note that previously known as secA. X2BNE8,P0A5Y9 No NC_002945.3 Mycobrowser_v2 CDS 3575210 3575854 . - 0 Mb3269c conserved protein Mb3269c, -, len: 214 aa. Equivalent to Rv3241c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins and to some putative ribosomal proteins e.g. Q9CCI7|ML0778 HYPOTHETICAL PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1234, E(): 1.3e-72,(89.3% identity in 206 aa overlap); Q9KYX2|SCE33.11c HYPOTHETICAL 27.9 KDA PROTEIN from Streptomyces coelicolor (254 aa), FASTA scores: opt: 487, E(): 2.2e-24, (47.6% identity in 210 aa overlap); Q9FLV3 PROTEIN SIMILAR TO RIBOSOMAL PROTEIN 30S SUBUNIT from Arabidopsis thaliana (Mouse-ear cress) (365 aa), FASTA scores: opt: 264, E(): 7e-10, (26.4% identity in 212 aa overlap); P19954|RR30_SPIOL|RPS22 PLASTID-SPECIFIC 30S RIBOSOMAL PROTEIN 1, chloroplast, from Spinacia oleracea (Spinach) (302 aa), FASTA scores: opt: 261, E(): 9.3e-10, (26.15% identity in 214 aa overlap); P47995|YSEA_STACA HYPOTHETICAL PROTEIN IN SECA 5'REGION (ORF1) (FRAGMENT) (BELONGS TO THE S30AE FAMILY OF RIBOSOMAL PROTEINS) from Staphylococcus carnosus (165 aa), FASTA scores: opt: 201,E(): 4.2e-06, (33.35% identity in 147 aa overlap); etc. Q7TWX2 No information pathways Rv3241c NC_002945.3 Mycobrowser_v2 CDS 3576170 3576811 . - 0 Mb3270c CONSERVED HYPOTHETICAL PROTEIN Mb3270c, -, len: 213 aa. Equivalent to Rv3242c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, highly similar in N-terminus to Q9CCI9|ML0776 HYPOTHETICAL PROTEIN from Mycobacterium leprae (85 aa), FASTA scores: opt: 324, E(): 1.7e-13,(78.1% identity in 64 aa overlap). Also similar to Q9RUJ7|DR1389 PUTATIVE COMPETENCE PROTEIN COMF from Deinococcus radiodurans (219 aa), FASTA scores: opt: 223,E(): 6.3e-07, (35.8% identity in 215 aa overlap); BAB50338|MLL3453 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (240 aa), FASTA scores: opt: 218,E(): 1.4e-06, (28.5% identity in 224 aa overlap); Q9A9Y1|CC0830 COMPETENCE PROTEIN F from Caulobacter crescentus (265 aa), FASTA scores: opt: 182, E(): 0.00026,(30.15% identity in 219 aa overlap); etc. Equivalent to AAK47682 from Mycobacterium tuberculosis strain CDC1551 (241 aa) but shorter 29 aa. Contains purine/pyrimidine phosphoribosyl transferases signature (PS00103). SEEMS TO BELONG TO PURINE/PYRIMIDINE PHOSPHORIBOSYL TRANSFERASE FAMILY. Q7TWX1 No conserved hypotheticals Rv3242c NC_002945.3 Mycobrowser_v2 CDS 3577759 3579510 . - 0 Mb3272c lpqB PROBABLE CONSERVED LIPOPROTEIN LPQB Mb3272c, lpqB, len: 583 aa. Equivalent to Rv3244c,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 583 aa overlap). Probable lpqB,conserved lipoprotein; contains appropriately placed lipoprotein signature (PS00013). Equivalent to Q9CCJ0|LPQB|ML0775 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (589 aa), FASTA scores: opt: 3375, E(): 1.4e-186,(87.9% identity in 579 aa overlap). Also similar to various proteins (in particular transferases) e.g. Q9KYX0|SCE33.13c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (615 aa), FASTA scores: opt: 228, E(): 1.3e-05,(25.5% identity in 624 aa overlap); O87992|BBLPS1.19c PUTATIVE GLUTAMINE AMIDOTRANSFERASE from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (628 aa),FASTA scores: opt: 162, E(): 0.079, (28.05% identity in 171 aa overlap); Q9L2F4|SC7A8.01 PUTATIVE SUGAR KINASE (FRAGMENT) from Streptomyces coelicolor (434 aa), FASTA scores: opt: 143, E(): 0.72, (27.65% identity in 293 aa overlap); etc. X2BMY9,Q7TWW9 No NC_002945.3 Mycobrowser_v2 CDS 3770379 3772739 . + 0 Mb3434 conserved protein Mb3434, -, len: 786 aa. Equivalent to Rv3401, len: 786 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 786 aa overlap). Hypothetical conserved protein, may be an hydrolase or a transferase, equivalent to Q49736|ML0392|B1620_F1_30 HYPOTHETICAL 88.1 KDA PROTEIN from Mycobacterium leprae (792 aa), FASTA scores: opt: 4820, E(): 0, (91.45% identity in 782 aa overlap). Also highly similar to Q9L2I8|SCF42.31c PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (792 aa), FASTA scores: opt: 3060, E(): 2.9e-179, (59.25% identity in 785 aa overlap); and similar to others e.g. Q9K109|NMB0390 MALTOSE PHOSPHORYLASE from Neisseria meningitidis (serogroup B) (752 aa), FASTA scores: opt: 980, E(): 3.5e-52, (29.2% identity in 774 aa overlap); Q9JSW8|MAPA|NMA2098 PUTATIVE MALTOSE PHOSPHORYLASE (EC 2.4.1.8) from Neisseria meningitidis (serogroup A) (752 aa), FASTA scores: opt: 956, E(): 1e-50, (28.4% identity in 764 aa overlap); O06993|YVDK_BACSU HYPOTHETICAL 88.3 KDA PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from Bacillus subtilis (757 aa), FASTA scores: opt: 926,E(): 6.9e-49, (28.5% identity in 754 aa overlap); Q9CF04|MAPA MALTOSEPHOSPHORYLASE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (751 aa), FASTA scores: opt: 907, E(): 1e-47, (26.95% identity in 753 aa overlap); P77154|YCJT_ECOLI|B1316 HYPOTHETICAL 84.9 KDA PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from Escherichia coli strain K12 (755 aa), FASTA scores: opt: 392, E(): 2.9e-16, (27.5% identity in 774 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),(27.2% identity in 802 aa overlap); note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle. Q7TWJ7 No intermediary metabolism and respiration Rv3401 NC_002945.3 Mycobrowser_v2 CDS 3579510 3581213 . - 0 Mb3273c mtrB TWO COMPONENT SENSORY TRANSDUCTION HISTIDINE KINASE MTRB Mb3273c, mtrB, len: 567 aa. Equivalent to Rv3245c,len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 567 aa overlap). mtrB, sensor-like histidine kinase (EC 2.7.3.-) (see citations below),equivalent to Q9CCJ1|MTRB OR ML0774 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (562 aa),FASTA scores: opt: 3208, E(): 7.4e-173, (88.7% identity in 566 aa overlap). Also similar to others e.g. Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (688 aa), FASTA scores: opt: 1355, E(): 1.1e-68, (48.95% identity in 515 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: MTCY369.03, E(): 1.5e-22; MTCY20G9.16, E(): 1.9e-17. SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES. X2BNF3,P59963 No NC_002945.3 Mycobrowser_v2 CDS 3581263 3581949 . - 0 Mb3274c mtrA TWO COMPONENT SENSORY TRANSDUCTION TRANSCRIPTIONAL REGULATORY PROTEIN MTRA Mb3274c, mtrA, len: 228 aa. Equivalent to Rv3246c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). mtrA, transcriptional activator, response regulator (see citations below),equivalent to Q9CCJ2|MTRA|ML0773 PUTATIVE TWO-COMPONENT RESPONSE REGULATOR from Mycobacterium leprae (228 aa),FASTA scores: opt: 1458, E(): 1.4e-85, (98.7% identity in 228 aa overlap). Also highly similar to others e.g. Q9F9J5|SCRA PUTATIVE RESPONSE REGULATOR from Streptomyces coelicolor (228 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9KYW8|SCE33.15c PUTATIVE TWO-COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (229 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9F868|REGX3 RESPONSE REGULATOR REGX3 from Mycobacterium smegmatis (228 aa), FASTA scores: opt: 730,E(): 2.3e-39, (50.90% identity in 222 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: U01971|MTU01971_1; Q11156|RGX3_MYCTU; MTCY20G9.17, E(): 0; MTCY31.31c, E(): 3.4e-29; MTCY369.02, E(): 5.7e-28. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages. X2BNU1,P0A5Z5 No NC_002945.3 Mycobrowser_v2 CDS 3582760 3584247 . - 0 Mb3276c sahH PROBABLE ADENOSYLHOMOCYSTEINASE SAHH (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) Mb3276c, sahH, len: 495 aa. Equivalent to Rv3248c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Probable sahH,adenosylhomocysteinase (EC 3.3.1.1), equivalent to Q9CCJ4|SAHH|ML0771 PUTATIVE S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE from Mycobacterium leprae (492 aa), FASTA scores: opt: 3019, E(): 1.3e-177, (91.4% identity in 489 aa overlap). Also highly similar to other adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces coelicolor (485 aa), FASTA scores: opt: 2258, E(): 5.7e-131, (70.0% identity in 483 aa overlap); P51540|SAHH_TRIVA from Trichomonas vaginalis (486 aa),FASTA scores: opt: 2005, E(): 1.8e-115, (62.05% identity in 477 aa overlap); P35007|SAHH_CATRO from Catharanthus roseus (Rosy periwinkle) (Madagascar periwinkle) (485 aa),FASTA scores: opt: 1941, E(): 1.5e-111, (60.15% identity in 492 aa overlap); etc. Has S-adenosyl-L-homocysteine hydrolase signature (PS00739). BELONGS TO THE ADENOSYLHOMOCYSTEINASE FAMILY. X2BN18,Q7TWW7 No NC_002945.3 Mycobrowser_v2 CDS 3600579 3601472 . - 0 Mb3293c wbbL1 dtdp-rha:a-d-glcnac-diphosphoryl polyprenol,a-3-l-rhamnosyl transferase wbbl1 (alpha-l-rhamnose-(1->3)-alpha-d-glcnac(1->p)-p-decaprenyl) Mb3293c, wbbL1, len: 297 aa. Equivalent to Rv3265c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 301 aa overlap). Probable wbbL1,dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL TRANSFERASE (EC 2.-.-.-) (see citation below), equivalent to Q9CCK7|WBBL|ML0752 PUTATIVE DTDP-RHAMNOSYL TRANSFERASE from Mycobacterium leprae (308 aa), FASTA scores: opt: 1788, E(): 3e-104, (85.05% identity in 301 aa overlap); and Q9RN50|WBBL|Q9RN49 (see note * below) DTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL,A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium smegmatis (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86, (72.35% identity in 293 aa overlap). Note that previously known as wbbL. [* Note: UNPUBLISHED (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme,dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol,a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A., Motichka K., Jucker M., Wu H.P.,Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W.,Pan F., Kimbrel S., Kundu M., McNeil M.]. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301 aa). Q7TTR5 No NC_002945.3 Mycobrowser_v2 CDS 3584352 3584987 . - 0 Mb3277c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3277c, -, len: 211 aa. Equivalent to Rv3249c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Possible transcriptional regulatory protein, tetR family, with similarity to several e.g. Q9AE61|ALKB1 PUTATIVE TETR-REGULATORY from Rhodococcus erythropolis (208 aa),FASTA scores: opt: 503, E(): 7.7e-26, (40.6% identity in 192 aa overlap); CAC37620 PUTATIVE TETR-REGULATORY PROTEIN from Prauserella rugosa (212 aa), FASTA scores: opt: 246,E(): 4.4e-09, (27.95% identity in 186 aa overlap); Q9K4B0|SC7E4.06 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (203 aa), FASTA scores: opt: 224,E(): 1.1e-07, (34.5% identity in 197 aa overlap); Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.27 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 191, E(): 1.6e-05, (28.35% identity in 180 aa overlap); etc. Equivalent to AAK47689 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 19 aa. COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Possible helix-turn helix motif at aa 44-65 (+6.66 SD). Q7TWW6 No regulatory proteins Rv3249c NC_002945.3 Mycobrowser_v2 CDS 3588275 3589663 . + 0 Mb3282 CONSERVED HYPOTHETICAL PROTEIN Mb3282, -, len: 462 aa. Equivalent to Rv3254, len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Conserved hypothetical protein, similar to CAC37877|SC1G7.02 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (440 aa), FASTA scores: opt: 606, E(): 6.2e-31, (31.7% identity in 445 aa overlap); O86550|SC1F2.13c HYPOTHETICAL 50.7 KDA PROTEIN from Streptomyces coelicolor (476 aa),FASTA scores: opt: 577, E(): 4.5e-29, (32.5% identity in 400 aa overlap); Q9L0A8|SCC24.09 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (468 aa), FASTA scores: opt: 380, E(): 1.3e-16, (30.7% identity in 391 aa overlap); BAB48792|MLL1411 PROBABLE FAD-DEPENDENT MONOOXYGENASE from Rhizobium loti (Mesorhizobium loti) (421 aa), FASTA scores: opt: 128, E(): 1.1, (25.2% identity in 397 aa overlap); Q9L7X9|BENF BENZOATE-SPECIFIC PORIN-LIKE PROTEIN from Pseudomonas putida (397 aa), FASTA scores: opt: 119,E(): 4, (24.85% identity in 157 aa overlap); etc. Also similar to N-terminus of AAK46259|MT1987 PUTATIVE FERREDOXIN REDUCTASE, ELECTRON TRANSFER COMPONENT from Mycobacterium tuberculosis strain CDC1551 (839 aa), FASTA scores: opt: 493, E(): 1.5e-23, (30.65% identity in 382 aa overlap). Q7TWW1 No conserved hypotheticals Rv3254 NC_002945.3 Mycobrowser_v2 CDS 3584984 3585166 . - 0 Mb3278c rubB PROBABLE RUBREDOXIN RUBB Mb3278c, -, len: 60 aa. Equivalent to Rv3250c, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Probable rubB,rubredoxin, highly similar to other rubredoxins e.g. Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA scores: opt: 391, E(): 2.2e-21, (83.05% identity in 59 aa overlap); Q9AE63|RUBA2 from Rhodococcus erythropolis (63 aa), FASTA scores: opt: 380, E(): 1.4e-20, (83.9% identity in 56 aa overlap); P42453|RUBR_ACICA|RUBA from Acinetobacter calcoaceticus (54 aa), FASTA scores: opt: 315, E(): 4.9e-16, (69.8% identity in 53 aa overlap); Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa), FASTA scores: opt: 298, E(): 8e-15, (64.15% identity in 53 aa overlap); Q9PGC3|XF0379 from Xylella fastidiosa (57 aa),FASTA scores: opt: 263, E(): 2.5e-12, (59.25% identity in 54 aa overlap); etc. Also similar to neighbouring ORF M. tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY. Q7TWW5 No intermediary metabolism and respiration Rv3250c NC_002945.3 Mycobrowser_v2 CDS 3585171 3585338 . - 0 Mb3279c rubA PROBABLE RUBREDOXIN RUBA Mb3279c, -, len: 55 aa. Equivalent to Rv3251c, len: 55 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 55 aa overlap). Probable rubA,rubredoxin, highly similar to other rubredoxins (but sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus erythropolis (61 aa), FASTA scores: opt: 335, E(): 1e-17,(73.6% identity in 53 aa overlap); P00272|RUB2_PSEOL|ALKG from Pseudomonas oleovorans (172 aa), FASTA scores: opt: 278, E(): 2.7e-13, (65.3% identity in 49 aa overlap); CAC38028|ALKG from Alcanivorax borkumensis (174 aa), FASTA scores: opt: 271, E(): 8.6e-13, (62.0% identity in 50 aa overlap); Q9WWW4|ALKG from Pseudomonas putida (175 aa),FASTA scores: opt: 270, E(): 1e-12, (61.8% identity in 55 aa overlap); etc. Also highly similar to C-terminus of Q9XBM1|ALKB ALKANE 1-MONOOXYGENASE (EC 1.14.15.3) from Prauserella rugosa (490 aa), FASTA scores: opt: 296, E(): 2.9e-14, (75.5% identity in 49 aa overlap). Also similar to neighbouring ORF Mycobacterium tuberculosis rubB (MTCY20B11.25c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY. Q7TWW4 No intermediary metabolism and respiration Rv3251c NC_002945.3 Mycobrowser_v2 CDS 3585338 3586588 . - 0 Mb3280c alkB PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN) Mb3280c, alkB, len: 416 aa. Equivalent to Rv3252c,len: 416 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 416 aa overlap). Probable alkB,transmembrane alkane-1-monooxygenase (EC 1.14.15.3),highly similar to many e.g. Q9AE68|ALKB2 from Rhodococcus erythropolis (408 aa), FASTA scores: opt: 2018, E(): 9.6e-122, (68.6% identity in 415 aa overlap); Q9AFD5|ALKB from Nocardioides sp. CF8 (483 aa), FASTA scores: opt: 1485, E(): 1.4e-87, (56.55% identity in 405 aa overlap); Q9XAU0|ALKB1 from Rhodococcus erythropolis (391 aa), FASTA scores: opt: 1400, E(): 3.3e-82, (62.6% identity in 396 aa overlap); Q9XBM1|ALKB from Prauserella rugosa (490 aa),FASTA scores: opt: 1266, E(): 1.5e-73, (57.55% identity in 410 aa overlap); CAC40954|ALKB4 from Rhodococcus erythropolis (386 aa), FASTA scores: opt: 1190, E(): 9.1e-69, (54.3% identity in 383 aa overlap); etc. Q7TWW3 No NC_002945.3 Mycobrowser_v2 CDS 3831660 3832613 . + 0 Mb3496 CONSERVED HYPOTHETICAL PROTEIN Mb3496, -, len: 317 aa. Equivalent to Rv3467, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(98.1% identity in 317 aa overlap). Conserved hypothetical ORF in REP13E12 repeat, identical to ORF's from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c, MTCY09F9.19,cMTCY336.17. Also identical to Mycobacterium bovis Q50655 HYPOTHETICAL 34.6 KD PROTEIN (317 aa) in identical repeat. Q7TWG4 No insertion seqs and phages Rv3467 NC_002945.3 Mycobrowser_v2 CDS 3586697 3588184 . - 0 Mb3281c POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN Mb3281c, -, len: 495 aa. Equivalent to Rv3253c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Possible cationic amino acid transporter, integral membrane protein, similar to many e.g. O69844|SC1C3.02 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Streptomyces coelicolor (503 aa), FASTA scores: opt: 1649, E(): 5.8e-92, (52.6% identity in 485 aa overlap); Q9AE69 PUTATIVE TRANSPORTER (FRAGMENT) from Rhodococcus erythropolis (385 aa), FASTA scores: opt: 1594, E(): 9.7e-89, (62.0% identity in 387 aa overlap); Q9PBD7|XF2207 CATIONIC AMINO ACID TRANSPORTER from Xylella fastidiosa (483 aa), FASTA scores: opt: 1079, E(): 1.2e-57, (40.55% identity in 493 aa overlap); Q9SRU9|F20H23.25 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Arabidopsis thaliana (Mouse-ear cress) (614 aa),FASTA scores: opt: 802, E(): 6.7e-41, (36.4% identity in 445 aa overlap); P30823|CTR1_RAT|SLC7A1|ATRC1 HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 from Rattus norvegicus (Rat) (624 aa), FASTA scores: opt: 782,E(): 1.1e-39, (36.1% identity in 432 aa overlap); etc. Relatives in Mycobacterium tuberculosis include: MTCY3G12.14, E(): 5.6e-31; MTCY39.19, E(): 1.6e-14. SEEMS TO BELONG TO THE APC FAMILY. Q7TWW2 No cell wall and cell processes Rv3253c NC_002945.3 Mycobrowser_v2 CDS 3589641 3590867 . - 0 Mb3283c manA PROBABLE MANNOSE-6-PHOSPHATE ISOMERASE MANA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE) Mb3283c, manA, len: 408 aa. Equivalent to Rv3255c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Probable manA,mannose-6-phosphate isomerase (EC 5.3.1.8), equivalent to Q9CCJ5|MANA|ML0765 from Mycobacterium leprae (410 aa),FASTA scores: opt: 2271, E(): 1.6e-133, (84.45% identity in 411 aa overlap). Also similar to many e.g. Q9KZL9|MANA from Streptomyces coelicolor (383 aa), FASTA scores: opt: 946, E(): 2.4e-51, (44.4% identity in 403 aa overlap); Q9KV87|VC0269 from Vibrio cholerae (399 aa), FASTA scores: opt: 726, E(): 1.1e-37, (34.15% identity in 404 aa overlap); Q9CMJ5|PMI|PM0829 from Pasteurella multocida (400 aa), FASTA scores: opt: 640, E(): 2.4e-32, (32.5% identity in 391 aa overlap); etc. SIMILAR TO FAMILY 1 OF MANNOSE-6-PHOSPHATE ISOMERASES. Q7TWW0 No NC_002945.3 Mycobrowser_v2 CDS 3590875 3591915 . - 0 Mb3284c conserved protein Mb3284c, -, len: 346 aa. Equivalent to Rv3256c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Conserved hypothetical protein, equivalent to Q9CCJ6|ML0764 HYPOTHETICAL PROTEIN from Mycobacterium leprae (365 aa),FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012,(31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap). Q7TWV9 No conserved hypotheticals Rv3256c NC_002945.3 Mycobrowser_v2 CDS 3604008 3604697 . + 0 Mb3296 CONSERVED HYPOTHETICAL PROTEIN Mb3296, -, len: 229 aa. Equivalent to Rv3268, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Conserved hypothetical protein, similar to Q9KZK4|SCE34.22 HYPOTHETICAL 27.1 KDA PROTEIN from Streptomyces coelicolor (263 aa), FASTA scores: opt: 442, E(): 5.9e-20, (40.1% identity in 242 aa overlap). Also weak similarity to N-terminal part (approximatively 1530 to 1740 residues) of O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 159, E(): 0.11, (30.35% identity in 224 aa overlap). Q7TWU8 No conserved hypotheticals Rv3268 NC_002945.3 Mycobrowser_v2 CDS 3795344 3796507 . - 0 IS1540-2 POSSIBLE TRANSPOSASE Mb3460c, -, len: 387 aa. Equivalent to Rv3430c,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Possible IS1540 transposase, similar to several e.g. Q49592 transposase from Mycobacterium intracellulare (340 aa), FASTA scores: opt: 1377, E(): 1.6e-81, (64.2% identity in 338 aa overlap); similarity is lost at C-terminus due to possible frameshift after aa 297. Q7TWI9 No insertion seqs and phages Rv3430c NC_002945.3 Mycobrowser_v2 CDS 3591912 3593309 . - 0 Mb3285c pmma probable phosphomannomutase pmma (pmm) (phosphomannose mutase) Mb3285c, manB, len: 465 aa. Equivalent to Rv3257c,len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 465 aa overlap). Probable manB,phosphomannomutase (EC 5.4.2.8) (see citation below),equivalent to Q9CCJ7|PMMA|ML0763 from Mycobacterium leprae (468 aa), FASTA scores: opt: 2533, E(): 2e-145, (83.1% identity in 468 aa overlap). Also similar to many e.g. Q9KZL6|MANB from Streptomyces coelicolor (454 aa), FASTA scores: opt: 1820, E(): 2e-102, (63.2% identity in 459 aa overlap); Q9PGN8|XF0260 from Xylella fastidiosa (500 aa),FASTA scores: opt: 1085, E(): 4.7e-58, (40.7% identity in 462 aa overlap); Q9EY19|MANB from Salmonella enterica subsp. arizonae (456 aa), FASTA scores: opt: 988, E(): 3.1e-52, (38.65% identity in 445 aa overlap); etc. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. Note that previously known as pmmA. Q7TWV8 No NC_002945.3 Mycobrowser_v2 CDS 3593411 3593902 . - 0 Mb3286c CONSERVED HYPOTHETICAL PROTEIN Mb3286c, -, len: 163 aa. Equivalent to Rv3258c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, equivalent to Q9CCJ8|ML0762 HYPOTHETICAL PROTEIN from Mycobacterium leprae (165 aa),FASTA scores: opt: 840, E(): 9.9e-42, (76.9% identity in 169 aa overlap). Also similar to Q9KZL4|SCE34.11c HYPOTHETICAL 15.0 KDA PROTEIN from Streptomyces coelicolor (140 aa), FASTA scores: opt: 353, E(): 1.1e-13, (48.3% identity in 147 aa overlap); and shows really weak similarity to other bacterial proteins. Q7TWV7 No conserved hypotheticals Rv3258c NC_002945.3 Mycobrowser_v2 CDS 3595143 3596138 . + 0 Mb3289 fbiA PROBABLE F420 BIOSYNTHESIS PROTEIN FBIA Mb3289, fbiA, len: 331 aa. Equivalent to Rv3261,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 331 aa overlap). Probable fbiA, F420 biosynthesis protein, equivalent to FBIA F420 biosynthesis protein fbiA from Mycobacterium bovis BCG (see citations below). Also equivalent, but shorter 46 aa, to Q9CCK1|ML0759 HYPOTHETICAL PROTEIN from Mycobacterium leprae (379 aa), FASTA scores: opt: 1855, E(): 3.9e-110,(79.3% identity in 333 aa overlap). Also similar to others e.g. Q9KZK9|SCE34.17 HYPOTHETICAL 33.6 KDA PROTEIN from Streptomyces coelicolor (319 aa), FASTA scores: opt: 1151,E(): 1.2e-65, (55.1% identity in 332 aa overlap); O29345|AF0917 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (296 aa), FASTA scores: opt: 469,E(): 1.7e-22, (31.15% identity in 302 aa overlap); Q58653|MJ1256 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (311 aa), FASTA scores: opt: 436, E(): 2.2e-20,(27.35% identity in 274 aa overlap); etc. X2BNV9,Q7TWV4 No intermediary metabolism and respiration Rv3261 NC_002945.3 Mycobrowser_v2 CDS 3596135 3597481 . + 0 Mb3290 fbiB PROBABLE F420 BIOSYNTHESIS PROTEIN FBIB Mb3290, fbiB, len: 448 aa. Equivalent to Rv3262,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Probable fbiB, F420 biosynthesis protein, equivalent to FBIB F420 biosynthesis protein fbiB from Mycobacterium bovis BCG (see citations below). Also equivalent to Q9CCK2|ML0758 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (457 aa), FASTA scores: opt: 2411, E(): 3.5e-137, (82.25% identity in 445 aa overlap). Also similar to Q9KZK8|SCE34.18 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (443 aa),FASTA scores: opt: 1180, E(): 2.2e-63, (51.75% identity in 433 aa overlap); other oxidoreductases in C-terminus; and several hypothetical bacterial proteins. X2BMN4,Q7TWV3 No intermediary metabolism and respiration Rv3262 NC_002945.3 Mycobrowser_v2 CDS 3597777 3599438 . + 0 Mb3291 PROBABLE DNA METHYLASE (MODIFICATION METHYLASE) (METHYLTRANSFERASE) Mb3291, -, len: 553 aa. Equivalent to Rv3263, len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 553 aa overlap). Probable DNA methylase (EC 2.1.1.-), equivalent to Q9CCK4|ML0756 PROBABLE DNA METHYLASE from Mycobacterium leprae (555 aa),FASTA scores: opt: 2980, E(): 2.1e-184, (81.9% identity in 541 aa overlap). Also similar to others e.g. P25240|MT57_ECOLI|ECO57IM MODIFICATION METHYLASE from Escherichia coli (544 aa), FASTA scores: opt: 595, E(): 1e-30, (30.35% identity in 507 aa overlap); P25201|MTA1_ACICA|ACCIM MODIFICATION METHYLASE ACCI from Acinetobacter calcoaceticus (540 aa), FASTA scores: opt: 366, E(): 5.7e-16, (23.35% identity in 467 aa overlap); Q56752|M-ACCI ACCI METHYLASE from Bergeyella zoohelcum (541 aa), FASTA scores: opt: 365, E(): 6.6e-16, (22.95% identity in 466 aa overlap); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Alternative start site at aa 25. Q7TWV2 No information pathways Rv3263 NC_002945.3 Mycobrowser_v2 CDS 3599498 3600577 . - 0 Mb3292c manC d-alpha-d-mannose-1-phosphate guanylyltransferase manb (d-alpha-d-heptose-1-phosphate guanylyltransferase) Mb3292c, manC, len: 359 aa. Equivalent to Rv3264c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable manC,mannose-1-phosphate guanyltransferase (EC 2.7.7.22),equivalent to Q9CCK6|RMLA2|ML0753 PUTATIVE SUGAR-PHOSPHATE NUCLEOTIDYL TRANSFERASE from Mycobacterium leprae (358 aa), FASTA scores: opt: 2075, E(): 2.7e-115, (86.9% identity in 359 aa overlap). Also similar to others e.g. Q9KZK6|SCE34.20c PUTATIVE NUCLEOTIDE PHOSPHORYLASE from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1314,E(): 2.2e-70, (57.0% identity in 358 aa overlap); Q9KZP4|SC1A8A.08 PUTATIVE MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Streptomyces coelicolor (831 aa),FASTA scores: opt: 699, E(): 8.6e-34, (34.45% identity in 354 aa overlap) (only similarity in N-terminus for this one); P74589|SLL1496 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Synechocystis sp. strain PCC 6803 (843 aa), FASTA scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa overlap) (only similarity in N-terminus for this one too); BAB59222|TVG0079558 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Thermoplasma volcanium (359 aa), FASTA scores: opt: 664, E(): 5.2e-32, (34.6% identity in 338 aa overlap); Q9ZTW5|GMP GDP-MANNOSE PYROPHOSPHORYLASE from Solanum tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E(): 2.3e-30, (34.65% identity in 361 aa overlap); etc. BELONGS TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that previously known as rmlA2. Q7TWV1 No NC_002945.3 Mycobrowser_v2 CDS 3607267 3607935 . - 0 Mb3299c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3299c, -, len: 222 aa. Equivalent to Rv3271c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable conserved integral membrane protein, similar to others e.g. Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa),FASTA scores: opt: 360, E(): 4.7e-16, (33.85% identity in 195 aa overlap); Q9X897|SCE2.02c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 357, E(): 7.3e-16,(33.85% identity in 195 aa overlap); Q9D0E0 2610024A01RIK PROTEIN from Mus musculus (Mouse) (288 aa), FASTA scores: opt: 191, E(): 3.7e-05, (23.65% identity in 207 aa overlap). Q7TWU6 No cell wall and cell processes Rv3271c NC_002945.3 Mycobrowser_v2 CDS 3601483 3602397 . - 0 Mb3294c rmlD dtdp-6-deoxy-l-lyxo-4-hexulose reductase rmld (dtdp-rhamnose modification protein) (dtdp-rhamnose biosynthesis protein) (dtdp-rhamnose synthase) Mb3294c, rmld, len: 304 aa. Equivalent to Rv3266c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Possible rmld,dTDP-rhamnose modification protein, highly similar to Q9CCK8 putative dTDP-rhamnose modification protein from Mycobacterium leprae (311 aa), FASTA scores, opt: 1440,E(): 1.1e-78, (74.7% identity in 312 aa overlap); and similar to several dtdp-4-dehydrorhamnose reductase (EC 1.1.1.133) e.g. STRL_STRGR|P29781 from Streptomyces griseus (304 aa), FASTA scores, opt: 788, E(): 0, (47.4% identity in 304 aa overlap). Q7TWV0 No NC_002945.3 Mycobrowser_v2 CDS 3602473 3603969 . + 0 Mb3295 conserved protein (cpsa-related protein) Mb3295, -, len: 498 aa. Equivalent to Rv3267, len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 498 aa overlap). Conserved hypothetical protein, CPSA-related protein, equivalent to Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FASTA scores: opt: 2523, E(): 5e-138,(78.9% identity in 498 aa overlap); and Q50160|CPSA (HYPOTHETICAL PROTEIN CPSA) from Mycobacterium leprae (516 aa), FASTA scores: opt: 868, E(): 1.2e-42, (34.7% identity in 507 aa overlap). Also similar to O06347|CPSA|Rv3484|MTCY13E12.37 CPSA from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 928, E(): 4.2e-46, (37.35% identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c HYPOTHETICAL 72.9 KDA PROTEIN from Mycobacterium tuberculosis (684 aa), FASTA scores: opt: 434, E(): 1.5e-17, (30.9% identity in 541 aa overlap). Also similar to Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (507 aa), FASTA scores: opt: 437, E(): 8.1e-18, (28.55% identity in 469 aa overlap); O68907 FRNA PROTEIN from Streptomyces roseofulvus (770 aa), FASTA scores: opt: 388,E(): 7.6e-15, (32.6% identity in 267 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A. Q7TWU9 No conserved hypotheticals Rv3267 NC_002945.3 Mycobrowser_v2 CDS 3604822 3605103 . + 0 Mb3297 conserved protein Mb3297, -, len: 93 aa. Equivalent to Rv3269, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, similar to many Mycobacterium proteins and chaperonins/heat shock proteins e.g. Q9CCL0|ML0748 HYPOTHETICAL PROTEIN from Mycobacterium leprae (92 aa),FASTA scores: opt: 427, E(): 6.8e-21, (73.65% identity in 91 aa overlap); Q10865|Rv1993c|MT2049|MTCY39.26c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (90 aa), FASTA scores: opt: 313, E(): 1.2e-13, (60.7% identity in 84 aa overlap); P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c (98 aa), FASTA scores: opt: 294, E(): 2.2e-12, (55.1% identity in 98 aa overlap); Q50827|MOPA|GROEL|CH60_MYCVA CHAPERONIN (PROTEIN CPN60) from Mycobacterium vaccae (120 aa), FASTA scores: opt: 107, E(): 2.1, (39.5% identity in 81 aa overlap); Q9AEB3|HSP65 HEAT SHOCK PROTEIN (FRAGMENT) from Mycobacterium gadium (122 aa), FASTA scores: opt: 102, E(): 4.4, (38.25% identity in 81 aa overlap); Q49374|CH60_MYCGN|MOPA|GROEL CHAPERONIN (PROTEIN CPN60) from Mycobacterium genavense (120 aa), FASTA scores: opt: 99, E(): 6.8, (40.25% identity in 82 aa overlap); etc. Q7TWU7 No virulence, detoxification, adaptation Rv3269 NC_002945.3 Mycobrowser_v2 CDS 3605114 3607270 . + 0 Mb3298 ctpC PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C CTPC Mb3298, ctpC, len: 718 aa. Equivalent to Rv3270,len: 718 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 718 aa overlap). Probable ctpC, metal cation-transport ATPase P-type (EC 3.6.3.-), integral membrane protein, equivalent to Q9CCL1|CTPC|ML0747 PUTATIVE CATION TRANSPORT ATPASE from Mycobacterium leprae (725 aa), FASTA scores: opt: 3908, E(): 0, (85.95% identity in 713 aa overlap). Also similar to O66027|MTAA METAL TRANSPORTING ATPASE MTA72 from Mycobacterium tuberculosis (680 aa), FASTA scores: opt: 3756, E(): 5.5e-213, (91.45% identity in 679 aa overlap); and to other ATPases e.g. Q9ZHC7|SILP_SALTY PUTATIVE CATION TRANSPORTING P-TYPE ATPASE from Salmonella typhimurium (824 aa), FASTA scores: opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa overlap); Q9HX93|PA3920 PROBABLE METAL TRANSPORTING P-TYPE ATPASE from Pseudomonas aeruginosa (792 aa), FASTA scores: opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. X2BNH2,P0A503 No cell wall and cell processes Rv3270 NC_002945.3 Mycobrowser_v2 CDS 3608036 3609220 . + 0 Mb3300 CONSERVED HYPOTHETICAL PROTEIN Mb3300, -, len: 394 aa. Equivalent to Rv3272, len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 394 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. Q9I672|PA0446 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (407 aa),FASTA scores: opt: 643, E(): 6.8e-32, (33.15% identity in 389 aa overlap); Q9RJU8|SCF41.21 PUTATIVE RACEMASE from Streptomyces coelicolor (403 aa), FASTA scores: opt: 541,E(): 1.1e-25, (31.95% identity in 385 aa overlap); O87838|SC8A6.04c PUTATIVE TRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 539, E(): 1.5e-25,(29.95% identity in 395 aa overlap); Q9I563|PA0882 from Pseudomonas aeruginosa (400 aa), FASTA scores: opt: 530,E(): 5.2e-25, (28.8% identity in 396 aa overlap); BAB60328|TVG1215416 L-CARNITINE DEHYDRATASE from Thermoplasma volcanium (399 aa), FASTA scores: opt: 529,E(): 6e-25, (32.9% identity in 383 aa overlap); etc. C-terminus is similar to Q49678|U00012_27|B1308_C3_195 from Mycobacterium leprae (130 aa) (60.0% identity in 115 aa overlap). Also partially similar to MTCY359_7 from M. tuberculosis (778 aa) (29.9% identity in 388 aa overlap). Q7TWU5 No conserved hypotheticals Rv3272 NC_002945.3 Mycobrowser_v2 CDS 3609225 3611519 . + 0 Mb3301 PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Mb3301, -, len: 764 aa. Equivalent to Rv3273, len: 764 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 764 aa overlap). Probable transmembrane protein (N-terminal part is hydrophobic) with probable carbonic anhydrase activity (in C-terminal part) (EC 4.2.1.1). Possibly involved in transport of sulfate. Equivalent to Q9CBA3|ML2279 PUTATIVE TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium leprae (496 aa), FASTA scores: opt: 1637, E(): 1.8e-89, (59.15% identity in 487 aa overlap). Similar to various proteins (principally sulfate transporters) e.g. Q9X927|SCH5.25 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (830 aa), FASTA scores: opt: 1325, E(): 8e-71,(40.85% identity in 788 aa overlap); Q9I729|PA0103 PROBABLE SULFATE TRANSPORTER from Pseudomonas aeruginosa (523 aa), FASTA scores: opt: 1015, E(): 1.3e-52, (39.95% identity in 488 aa overlap); Q9KN88|VCA0077 SULFATE PERMEASE FAMILY PROTEIN from Vibrio cholerae (553 aa),FASTA scores: opt: 629, E(): 9.6e-30, (30.95% identity in 423 aa overlap); etc. C-terminal part (aa 550-764) shows similarity to carbonic anhydrase e.g. P27134|CYNT_SYNP7 CARBONIC ANHYDRASE (EC 4.2.1.1) (272 aa), FASTA scores: opt: 350, E(): 8.1e-15, (33.8% identity in 201 aa overlap). Contains PS00704 Prokaryotic-type carbonic anhydrases signature 1. SEEMS TO BELONG TO THE SULP FAMILY. Q7TWU4 No intermediary metabolism and respiration Rv3273 NC_002945.3 Mycobrowser_v2 CDS 3611508 3612677 . - 0 Mb3302c fadE25 PROBABLE ACYL-COA DEHYDROGENASE FADE25 Mb3302c, fadE25, len: 389 aa. Equivalent to Rv3274c, len: 389 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 389 aa overlap). Probable fadE25, Acyl-CoA Dehydrogenase (EC 1.3.99.-),equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE ACYL-COA DEHYDROGENASE FADE25 from Mycobacterium leprae (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05% identity in 389 aa overlap). Also similar to many e.g. Q9RIQ5|FADE FATTY ACID ACYL-COA DEHYDROGENASE from Streptomyces lividans (385 aa), FASTA scores: opt: 1692,E(): 4.9e-99, (67.35% identity in 383 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in 376 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 1209, E(): 1.1e-68, (51.7% identity in 377 aa overlap); P52042|ACDS_CLOAB|BCD from Clostridium acetobutylicum (379 aa), FASTA scores: opt: 1056, E(): 4.6e-59, (44.6% identity in 379 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. X2BN17,P63428 No lipid metabolism Rv3274c NC_002945.3 Mycobrowser_v2 CDS 3612702 3613226 . - 0 Mb3303c purE PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT PURE (AIR CARBOXYLASE) (AIRC) Mb3303c, purE, len: 174 aa. Equivalent to Rv3275c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 174 aa overlap). Probable purE,phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21), equivalent to P46702|PUR6_MYCLE|PURE|ML0736|B1308_F3_98 from Mycobacterium leprae (171 aa), FASTA scores: opt: 878,E(): 1.5e-43, (81.55% identity in 168 aa overlap). Also similar to others e.g. Q9AXD0|AIRC from Nicotiana tabacum (Common tobacco) (623 aa), FASTA scores: opt: 712, E(): 1.4e-33, (69.35% identity in 160 aa overlap) (similarity in C-terminal part for this one); Q44679|PUR6_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (177 aa), FASTA scores: opt: 651, E(): 1.5e-30, (68.25% identity in 148 aa overlap); Q55498|PUR6_SYNY3|PURE|SLL0901 from Synechocystis sp. strain PCC 6803 (176 aa), FASTA scores: opt: 639, E(): 7.1e-30, (60.5% identity in 167 aa overlap); etc. Q7TWU3 No NC_002945.3 Mycobrowser_v2 CDS 3645666 3646145 . + 0 Mb3332 conserved protein Mb3332, -, len: 159 aa. Equivalent to Rv3304, len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Hypothetical conserved protein, very similar to Q9CCL6|ML0711 HYPOTHETICAL PROTEIN from Mycobacterium leprae (159 aa),FASTA scores: opt: 1041, E(): 6.1e-62, (91.8% identity in 159 aa overlap); and Q49927|L308_F3_97 from M. leprae (174 aa), FASTA scores: opt: 974, E(): 1.8e-57, (91.2% identity in 149 aa overlap) . Also highly similar to Q9AD81|SCK13.10c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (145 aa), FASTA scores: opt: 615,E(): 7.8e-34, (60.55% identity in 147 aa overlap); and shows some similarity to other various hypotheticals proteins. ORF continues upstream with possible start at 2198 (equivalent to AAK47746 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 53 aa). Q7TWS3 No conserved hypotheticals Rv3304 NC_002945.3 Mycobrowser_v2 CDS 3613223 3614512 . - 0 Mb3304c purK PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT PURK (AIR CARBOXYLASE) (AIRC) Mb3304c, purK, len: 429 aa. Equivalent to Rv3276c,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Probable purK,phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21), equivalent to P46701|PURK_MYCLE|ML0735|B1308_F1_32 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT from Mycobacterium leprae (439 aa), FASTA scores: opt: 2168, E(): 2.3e-123, (76.15% identity in 444 aa overlap). Also similar to others e.g. Q44678|PURK_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (413 aa), FASTA scores: opt: 1179, E(): 9.1e-64, (48.35% identity in 389 aa overlap); Q9KZ85|PURK from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1150, E(): 4.7e-62, (55.35% identity in 345 aa overlap); Q54975|PURK_SYNP7 from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (395 aa), FASTA scores: opt: 772,E(): 3e-39, (38.1% identity in 383 aa overlap); etc. BELONGS TO THE PURK / PURT FAMILY. X2BNX8,P65899 No NC_002945.3 Mycobrowser_v2 CDS 3614466 3615284 . + 0 Mb3305 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3305, -, len: 271 aa. Equivalent to Rv3277, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 271 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 49 aa, to Q49673|B1308_C1_121|ML0734 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (228 aa), FASTA scores: opt: 1266,E(): 6.1e-78, (84.2% identity in 228 aa overlap). Also similar to various proteins (principally unknowns) e.g. Q9KZ84|SCE25.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (190 aa), FASTA scores: opt: 197,E(): 3.6e-06, (32.0% identity in 150 aa overlap); BAB50058|MLL3086 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (136 aa), FASTA scores: opt: 176,E(): 6.9e-05, (34.7% identity in 147 aa overlap); O29640|AF0615 HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (129 aa), FASTA scores: opt: 120, E(): 0.38,(23.35% identity in 120 aa overlap); Q9KJU8|GTCA TEICHOIC ACID GLYCOSYLATION PROTEIN from Listeria innocua (145 aa),FASTA scores: opt: 117, E(): 0.67, (23.85% identity in 151 aa overlap); etc. Equivalent to AAK47718 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 16 aa. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Q7TWU2 No cell wall and cell processes Rv3277 NC_002945.3 Mycobrowser_v2 CDS 3615239 3615757 . - 0 Mb3306c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3306c, -, len: 172 aa. Equivalent to Rv3278c,len: 172 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 172 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CCL2|ML0733 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (172 aa), FASTA scores: opt: 1024, E(): 6e-61, (83.15% identity in 172 aa overlap); and Q49672|B1308_F2_67 HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 1024, E(): 6.3e-61, (83.15% identity in 172 aa overlap) (this is certainly the same putative protein but with N-terminus longer). Also some similarity to other hypothetical proteins (generally membrane proteins) e.g. O26822|MTH726 HYPOTHETICAL PROTEIN from Methanobacterium thermoautotrophicum (204 aa), FASTA scores: opt: 147, E(): 0.0079, (24.6% identity in 187 aa overlap); Q9X8H4|SCE9.01 HYPOTHETICAL 47.7 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (436 aa), FASTA scores: opt: 151, E(): 0.0079,(28.1% identity in 153 aa overlap). Q7TWU1 No cell wall and cell processes Rv3278c NC_002945.3 Mycobrowser_v2 CDS 3615800 3616600 . - 0 Mb3307c birA POSSIBLE BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGASE) Mb3307c, birA, len: 266 aa. Equivalent to Rv3279c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 266 aa overlap). Possible birA,bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15),equivalent to Q9CCL3|BIRA|ML0732 BIOTIN APO-PROTEIN LIGASE from Mycobacterium leprae (274 aa), FASTA scores: opt: 1189, E(): 2.3e-66, (71.2% identity in 271 aa overlap). But as it lacks a BirA h-t-h domain at N-terminus, may simply be biotin apo-protein ligase. Also similar to others e.g. Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312 aa), FASTA scores: opt: 347, E(): 2.7e-14, (32.95% identity in 270 aa overlap); Q9HWC0|BIRA|PA4280 from Pseudomonas aeruginosa (312 aa), FASTA scores: opt: 335,E(): 1.5e-13, (34.2% identity in 272 aa overlap); Q9A6Z0|CC1936 from Caulobacter crescentus (250 aa), FASTA scores: opt: 332, E(): 1.9e-13, (33.6% identity in 238 aa overlap); P06709|BIRA_ECOLI (321 aa), FASTA scores: opt: 314, E(): 3.1e-12, (34.15% identity in 249 aa overlap); etc. SIMILAR WITH OTHER BACTERIAL BIRA AND WITH EUKARYOTIC BIOTIN APO-PROTEIN LIGASE. Q7TWU0 No NC_002945.3 Mycobrowser_v2 CDS 3619453 3620346 . + 0 Mb3311 sseA PROBABLE THIOSULFATE SULFURTRANSFERASE SSEA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) Mb3311, sseA, len: 297 aa. Equivalent to Rv3283,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 297 aa overlap). Probable sseA,thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 PUTATIVE THIOSULFATE SULFURTRANSFERASE SSEA from Mycobacterium leprae (296 aa), FASTA scores: opt: 1742, E(): 5.5e-108,(83.45% identity in 296 aa overlap). Also highly similar to others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1057, E(): 1.2e-62, (53.86% identity in 273 aa overlap); P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1006, E(): 2.7e-59, (51.25% identity in 277 aa overlap); P71121|THTR_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (225 aa), FASTA scores: opt: 897, E(): 3.6e-52, (59.05% identity in 215 aa overlap); etc. Also highly similar to O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c|M T0837|MTV043.07c|THTR_MYCTU PUTATIVE THIOSULFATE SULFURTRANSFERASE (EC 2.8.1.1) from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 955, E(): 6.3e-56, (50.2% identity in 271 aa overlap); and Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium leprae (277 aa),FASTA scores: opt: 931, E(): 2.5e-54, (48.9% identity in 276 aa overlap). Shows some similarity to MTCY339.19c (30.3% identity in 254 aa overlap). Contains PS00683 Rhodanese C-terminal signature. BELONGS TO THE RHODANESE FAMILY. X2BN61,Q7TWT6 No intermediary metabolism and respiration Rv3283 NC_002945.3 Mycobrowser_v2 CDS 3623476 3623913 . - 0 Mb3315c rsbW ANTI-SIGMA FACTOR RSBW (SIGMA NEGATIVE EFFECTOR) Mb3315c, rsbW, len: 145 aa. Equivalent to Rv3287c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). rsbW (alternate gene name: usfX), anti-sigma factor (see citations below),similar to Q49667|B1308_F3_89 from Mycobacterium leprae (75 aa), FASTA scores: opt: 308, E(): 2.5e-15, (72.2% identity in 72 aa overlap); Q9R3X8|PRS1|USHX|PRS PRS1 PROTEIN (ANTI-SIGMA FACTOR) from Streptomyces coelicolor (137 aa), FASTA scores: opt: 184, E(): 3.7e-06, (36.8% identity in 106 aa overlap); O50231 PUTATIVE SIGMA-B REGULATOR from Bacillus licheniformis (160 aa), FASTA scores: opt: 122, E(): 0.13, (23.9% identity in 92 aa overlap); and P17904|RSBW_BACSU ANTI-SIGMA B FACTOR (SIGMA-B NEGATIVE EFFECTOR RSBW) from Bacillus subtilis (160 aa), FASTA scores: opt: 108, E(): 1.3, (21.25% identity in 127 aa overlap). Equivalent to AAK47729 from Mycobacterium tuberculosis strain CDC1551 (145 aa) but longer 99 aa. INDUCTION BY HEAT SHOCK, SALT STRESS,OXIDATIVE STRESS, GLUCOSE LIMITATION AND OXYGEN LIMITATION. N-terminus shortened since first submission (previously 242 aa). Q7TWT4 No NC_002945.3 Mycobrowser_v2 CDS 3624970 3626319 . - 0 Mb3318c lat PROBABLE L-LYSINE-EPSILON AMINOTRANSFERASE LAT (L-LYSINE AMINOTRANSFERASE) (LYSINE 6-AMINOTRANSFERASE) Mb3318c, lat, len: 449 aa. Equivalent to Rv3290c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable lat,lysine-epsilon aminotransferase (EC 2.6.1.36), similar to Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa),FASTA scores: opt: 1702, E(): 1.1e-99, (60.35% identity in 439 aa overlap); and Q01767|Q53823|LAT_STRCL from Streptomyces clavuligerus (457 aa), FASTA scores: opt: 1676, E(): 4.9e-98, (60.15% identity in 434 aa overlap). Also some similarity to 4-AMINOBUTYRATE AMINOTRANSFERASE PROTEINS (GAMMA-AMINO-N-BUTYRATE TRANSAMINASES). BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BNI6,P63510 No NC_002945.3 Mycobrowser_v2 CDS 3616650 3618296 . + 0 Mb3308 accD5 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 ACCD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) Mb3308, accD5, len: 548 aa. Equivalent to Rv3280,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Probable accD5,propyonyl-CoA carboxylase beta chain 5 (EC 6.4.1.3),equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 from Mycobacterium leprae (549 aa), FASTA scores: opt: 3241,E(): 4e-192, (88.7% identity in 549 aa overlap). Also similar to many e.g. O87201|DTSR2 DTSR2 PROTEIN INVOLVED IN GLUTAMATE PRODUCTION from orynebacterium glutamicum (Brevibacterium flavum) (537 aa), FASTA scores: opt: 2604,E(): 6.9e-153, (74.1% identity in 529 aa overlap) (see first citation below); P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa), FASTA scores: opt: 2466, E(): 2.2e-144, (70.2% identity in 530 aa overlap); O88155|DTSR1 DTSR1 PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (543 aa), FASTA scores: opt: 2375, E(): 8.8e-139, (67.1% identity in 529 aa overlap (see citation below); Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA scores: opt: 2360, E(): 7.3e-138, (67.9% identity in 533 aa overlap); O24789|MXPCCB from Myxococcus xanthus (524 aa), FASTA scores: opt: 1868, E(): 1.5e-107, (56.85% identity in 524 aa overlap); etc. Also similar with METHYLMALONYL-COA DECARBOXYLASES e.g. O59018|PH1287 from Pyrococcus horikoshii (522 aa), FASTA scores: opt: 1841,E(): 6.7e-106, (54.15% identity in 528 aa overlap). Also similarity with MTCY427.28 (43.8% identity in 434 aa overlap). BELONGS TO THE ACCD/PCCB FAMILY. Q7TWT9 No NC_002945.3 Mycobrowser_v2 CDS 3618277 3618747 . + 0 Mb3309 acce5 probable bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (epsilon chain) acce5 Mb3309, -, len: 156 aa. Similar to Rv3281, len: 177 aa, from Mycobacterium tuberculosis strain H37Rv, (88.1% identity in 177 aa overlap). Conserved hypothetical protein, equivalent (but longer 14 aa and with a gap between aa 82-102) to AAK47723|MT3380 from Mycobacterium tuberculosis strain CDC1551 (142 aa), FASTA scores: opt: 830, E(): 3.1e-40, (86.5% identity in 163 aa overlap). C-terminus highly similar to Q49671|B1308_C3_211|ML0730 from Mycobacterium leprae (84 aa), FASTA scores: opt: 393,E(): 7.6e-16, (68.95% identity in 87 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177 aa). Q7TWT8 No NC_002945.3 Mycobrowser_v2 CDS 3618744 3619412 . + 0 Mb3310 CONSERVED HYPOTHETICAL PROTEIN Mb3310, -, len: 222 aa. Equivalent to Rv3282, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 222 aa overlap). Conserved hypothetical protein, equivalent to Q49670|ML0729 1308R (HYPOTHETICAL PROTEIN ML0729) from Mycobacterium leprae (213 aa), FASTA scores: opt: 945, E(): 5.5e-54, (68.55% identity in 213 aa overlap). Also similar to Q9EWV6|2SCK31.18 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (206 aa), FASTA scores: opt: 459, E(): 1.3e-22, (47.35% identity in 209 aa overlap); P74331|MAF OR SLL0905 MAF PROTEIN from Synechocystis sp. strain PCC 6803 (195 aa),FASTA scores: opt: 401, E(): 6.9e-19, (43.0% identity in 207 aa overlap); and shows weak similarity with various proteins e.g. Q9BUL6 ACETYLSEROTONIN O-METHYLTRANSFERASE-LIKE from Homo sapiens (Human) (621 aa), FASTA scores: opt: 282, E(): 8.9e-11, (31.6% identity in 193 aa overlap); O95671|ASMTL ASMTL PROTEIN from Homo sapiens (Human) (629 aa), FASTA scores: opt: 282, E(): 9e-11, (31.6% identity in 193 aa overlap); BAB51136|MLR4491 MAF PROTEIN from Rhizobium loti (Mesorhizobium loti) (199 aa), FASTA scores: opt: 269,E(): 2.3e-10, (29.3% identity in 198 aa overlap); etc. X2BMR0,Q7TWT7 No conserved hypotheticals Rv3282 NC_002945.3 Mycobrowser_v2 CDS 3622694 3623479 . - 0 Mb3314c sigF alternative rna polymerase sigma factor sigf Mb3314c, sigF, len: 261 aa. Equivalent to Rv3286c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable sigF, stress response/stationary phase RNA polymerase sigma factor (see citations below), similar to several Streptomyces RNA polymerase sigma factors e.g. Q9RPC8|SIGH from Streptomyces coelicolor A3(2) (354 aa), FASTA scores: opt: 869, E(): 1.1e-45, (51.15% identity in 258 aa overlap); Q9RIT0|SIG1 from Streptomyces coelicolor (361 aa), FASTA scores: opt: 869, E(): 1.1e-45, (51.15% identity in 258 aa overlap); Q9ADM4|2SC10A7.38c from Streptomyces coelicolor (318 aa), FASTA scores: opt: 776, E(): 4.6e-40, (48.75% identity in 240 aa overlap); P37971|RPOF_STRCO|SIGF|RPOX|2SCD60.01c from Streptomyces coelicolor (287 aa), FASTA scores: opt: 717, E(): 1.6e-36,(44.5% identity in 245 aa overlap); P37970|RPOF_STRAU|SIGF|RPOX from Streptomyces aureofaciens (297 aa); etc. Contains possible helix-turn-helix motif at aa 229-250 (+7.38 SD). SIMILAR TO THE SIGMA-70 FACTOR FAMILY. Seems expressed in stationary phase and under stress conditions in vitro (see citations below). P96891 No NC_002945.3 Mycobrowser_v2 CDS 3662164 3662592 . - 0 Mb3349c vapc44 possible toxin vapc44. contains pin domain. Mb3349c, -, len: 142 aa. Equivalent to Rv3320c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P95023|Rv2530c|MTCY159.26 (139 aa),FASTA scores: opt: 292, E(): 4.8e-14, (41.5% identity in 135 aa overlap); O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 287, E(): 1.1e-13, (41.6% identity in 125 aa overlap); O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 252, E(): 3.3e-11, (37.8% identity in 127 aa overlap); etc. Q7TWQ9 No virulence, detoxification, adaptation Rv3320c NC_002945.3 Mycobrowser_v2 CDS 3631300 3635841 . + 0 Mb3324 lhr PROBABLE ATP-DEPENDENT HELICASE LHR (LARGE HELICASE-RELATED PROTEIN) Mb3324, lhr, len: 1513 aa. Equivalent to Rv3296,len: 1512 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1512 aa overlap). Probable lhr,ATP-dependent helicase (EC 3.6.1.-), similar to others e.g. P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.55% identity in 1569 aa overlap); AAG56642|LHR from Escherichia coli stain O157:H7 EDL933 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.6% identity in 1561 aa overlap); O86821|SC7C7.16c from Streptomyces coelicolor (1690 aa), FASTA scores: opt: 2919, E(): 7e-159, (53.55% identity in 1703 aa overlap); Q9HYW9|PA3272 from Pseudomonas aeruginosa (1448 aa), FASTA scores: opt: 907, E(): 6.2e-44, (35.85% identity in 1512 aa overlap); etc. SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND TO HELICASE C-TERMINAL DOMAIN. Contains PS00017 ATP/GTP-binding site motif A and possible helix-turn-helix motif. Q7TWS8 No information pathways Rv3296 NC_002945.3 Mycobrowser_v2 CDS 3626853 3628100 . + 0 Mb3320 CONSERVED HYPOTHETICAL PROTEIN Mb3320, -, len: 415 aa. Equivalent to Rv3292, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Conserved hypothetical protein, similar to P76097|YDCJ_ECOLI|B1423 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain K12 (447 aa), FASTA scores: opt: 747, E(): 5.6e-39,(38.55% identity in 449 aa overlap); BAB35451|ECS2028 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain O157:H7 (447 aa), FASTA scores: opt: 744, E(): 8.6e-39,(38.3% identity in 449 aa overlap); AAG56352|Z2297 PROTEIN from Escherichia coli O157:H7 EDL933 (212 aa), FASTA scores: opt: 454, E(): 4.6e-21, (41.75% identity in 206 aa overlap); and similar in part with Q49664|B1308_C1_136 from Mycobacterium leprae (71 aa), FASTA scores: opt: 305,E(): 3.2e-12, (70.0% identity in 70 aa overlap). X2BMS0 No conserved hypotheticals Rv3292 NC_002945.3 Mycobrowser_v2 CDS 3628127 3629611 . + 0 Mb3321 pcd PROBABLE PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE) Mb3321, pcd, len: 494 aa. Equivalent to Rv3293,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 494 aa overlap). Probable pcd,piperideine-6-carboxylic acid dehydrogenase (EC 1.5.-.-),highly similar to others e.g. O85725|PCD SEMIALDEHYDE DEHYDROGENASE from Streptomyces clavuligerus (512 aa),FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity in 496 aa overlap) (see first citation below); Q9I4U7|PA1027 PROBABLE ALDEHYDE DEHYDROGENASE from Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984,E(): 1.4e-107, (64.5% identity in 493 aa overlap); BAB49892|MLL2867 ALDEHYDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 1964, E(): 2e-106, (62.8% identity in 476 aa overlap); Q9A8Y1|CC1216 ALDEHYDE DEHYDROGENASE from Caulobacter crescentus (507 aa), FASTA scores: opt: 1909, E(): 3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE from Streptomyces clavuligerus (496 aa), FASTA scores: opt: 1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap); and Q9F1U8|PCD PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE from 'Flavobacterium' lutescens (510 aa), FASTA scores: opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa overlap) (see second citation below); etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Note that ORF Rv3290c seems to encoded the putative lat enzyme. Previously known as aldB. Q7TWT1 No intermediary metabolism and respiration Rv3293 NC_002945.3 Mycobrowser_v2 CDS 3917726 3918511 . - 0 Mb3566c hsae PROBABLE HYDRATASE Mb3566c, -, len: 261 aa. Equivalent to Rv3536c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable hydratase,2-oxo-hepta-3-ene-1,7-dioate hydratase (EC 4.2.1.-) or 2-keto-4-pentenoate hydratase (EC 4.2.1.-). Indeed, highly similar to many 2-oxo-hepta-3-ene-1,7-dioate hydratases e.g. Q9CKS2|HPAH|PM1534 from Pasteurella multocida (267 aa) FASTA scores: opt: 743, E(): 1.5e-39, (45.5% identity in 266 aa overlap) Q9RZ31|DRA0122 from Deinococcus radiodurans (268 aa), FASTA scores: opt: 709, E(): 2e-37,(45.5% identity in 266 aa overlap); Q9HWQ4|HPCG|PA4127 from Pseudomonas aeruginosa (267 aa), FASTA scores: opt: 703, E(): 4.8e-37, (45.1% identity in 266 aa overlap); Q46982|HPAH|HPCG from Escherichia colis strain ATCC 11105 (267 aa), FASTA scores: opt: 679, E(): 1.6e-35, (41.35% identity in 266 aa overlap); etc. But also highly similar to many 2-keto-4-pentenoate hydratases (2-hydroxypentadienoic acidhydratases) e.g. Q9LAF7|PHED from Bacillus thermoglucosidasius (258 aa), FASTA scores: opt: 698, E(): 9.7e-37, (42.45% identity in 252 aa overlap); Q52442|BPHH from Pseudomonas sp (260 aa) FASTA scores: opt: 675, E(): 2.7e-35, (41.4% identity in 251 aa overlap); P77608|MHPD_ECOLI|B0350 from Escherichia coli strain K12 (269 aa), FASTA scores: opt: 674, E(): 3.2e-35,(42.75% identity in 255 aa overlap); Q52038|BPHX1 from Pseudomonas pseudoalcaligenes (260 aa), FASTA scores: opt: 663, E(): 1.5e-34, (40.6% identity in 251 aa overlap); etc. Q7TW96 No intermediary metabolism and respiration Rv3536c NC_002945.3 Mycobrowser_v2 CDS 3629711 3630520 . - 0 Mb3322c CONSERVED HYPOTHETICAL PROTEIN Mb3322c, -, len: 269 aa. Equivalent to Rv3294c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 269 aa overlap). Conserved hypothetical protein, similar to several conserved hypothetical proteins from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa), FASTA scores: opt: 682, E(): 3.6e-37, (44.85% identity in 243 aa overlap); O53329|Rv3179 (454 aa), FASTA scores: opt: 561, E(): 3.3e-29, (42.20% identity in 218 aa overlap); Q10849|YK08_MYCTU|Rv2008c (441 aa), FASTA scores: opt: 194, E(): 3.9e-05, (30.10% identity in 239 aa overlap). Also some similarity with proteins from other organisms. Replace previous Rv3294 on opposite strand. Q7TWT0 No conserved hypotheticals Rv3294c NC_002945.3 Mycobrowser_v2 CDS 3630591 3631256 . + 0 Mb3323 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3323, -, len: 221 aa. Equivalent to Rv3295, len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable transcriptional regulator tetR-family, equivalent to Q9CCL4|ML0717 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (223 aa), FASTA scores: opt: 1260, E(): 7.2e-75, (85.45% identity in 220 aa overlap). Also highly similar to other streptomyces regulators e.g. Q9RD77|SCF43.11 from Streptomyces coelicolor (205 aa), FASTA scores: opt: 442, E(): 9.8e-22,(38.6% identity in 202 aa overlap); Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa), FASTA scores: opt: 215,E(): 5.9e-07, (31.85% identity in 135 aa overlap); Q9L0U5|SCD35.06 from Streptomyces coelicolor (240 aa),FASTA scores: opt: 214, E(): 7.4e-07, (28.2% identity in 156 aa overlap); etc. SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Contains potential helix-turn-helix motif at aa 33-54 (+4.42 SD). Q7TWS9 No regulatory proteins Rv3295 NC_002945.3 Mycobrowser_v2 CDS 3635845 3636612 . + 0 Mb3325 nei PROBABLE ENDONUCLEASE VIII NEI Mb3325, nei, len: 255 aa. Equivalent to Rv3297,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Probable nei,endonuclease VIII (EC 3.2.-.-), similar to others e.g. O86820|END8_STRCO|NEI|SC7C7.15c from Streptomyces coelicolor (276 aa), FASTA scores: opt: 770, E(): 1.2e-42,(50.35% identity in 268 aa overlap); P50465|END8_ECOLI|NEI|B0714 from Escherichia coli strain K12 (262 aa), FASTA scores: opt: 310, E(): 6.3e-13, (28.1% identity in 267 aa overlap); AAG55037|NEI from Escherichia coli strain O157:H7 EDL933 (263 aa), FASTA scores: opt: 301, E(): 2.4e-12, (27.7% identity in 267 aa overlap); etc. BELONGS TO THE FPG FAMILY. X2BMS5,P64157 No information pathways Rv3297 NC_002945.3 Mycobrowser_v2 CDS 3636635 3637549 . - 0 Mb3326c lpqC POSSIBLE ESTERASE LIPOPROTEIN LPQC Mb3326c, lpqC, len: 304 aa. Equivalent to Rv3298c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Possible lpqC,esterase lipoprotein (EC 3.1.-.-), equivalent to Q9CCL5|LPQC|ML0715 PUTATIVE SECRETED HYDROLASE from Mycobacterium leprae (304 aa), FASTA scores: opt: 1543,E(): 1.3e-87, (71.6% identity in 303 aa overlap); and Q49658|B1308_F2_43 TUBULIN FAMILY PROTEIN from Mycobacterium leprae (302 aa), FASTA scores: opt: 1541,E(): 1.7e-87, (72.0% identity in 300 aa overlap). Also similar to Q9I5Z3|PA0543 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (322 aa), FASTA scores: opt: 439,E(): 8.9e-20, (32.3% identity in 319 aa overlap); Q9F2K9|SCH63.19c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (348 aa), FASTA scores: opt: 394,E(): 5.5e-17, (30.25% identity in 334 aa overlap); etc. And similar to O86367|LPQP|Rv0671|MTCI376.03c from Mycobacterium tuberculosis strain H37Rv (280 aa), FASTA scores: opt: 519, E(): 9.8e-25, (39.25% identity in 275 aa overlap). Probably lipoprotein, esterase membrane-bound,with 18 aa signal sequence as it contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site. Q7TWS7 No NC_002945.3 Mycobrowser_v2 CDS 3637576 3640488 . - 0 Mb3327c atsB PROBABLE ARYLSULFATASE ATSB (ARYL-SULFATE SULPHOHYDROLASE) (SULFATASE) Mb3327c, atsB, len: 970 aa. Equivalent to Rv3299c,len: 970 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 970 aa overlap). Probable atsB,arylsulfatase (EC 3.1.6.1), similar to P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from Pseudomonas aeruginosa (535 aa), FASTA scores: opt: 645,E(): 5.8e-31, (32.0% identity in 550 aa overlap); Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa), FASTA scores: opt: 504, E(): 1.7e-22, (26.3% identity in 566 aa overlap); and P20713|ATSA|ARS_KLEAE (precursor) from Klebsiella pneumoniae (464 aa), FASTA scores: opt: 502,E(): 1.8e-22, (26.85% identity in 451 aa overlap). Also similar to Mycobacterium tuberculosis proteins O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6% identity in 796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa) (38.4% identity in 797 aa overlap). Equivalent to AAK47741 from Mycobacterium tuberculosis strain CDC1551 (992 aa) but shorter 22 aa. Contains PS00523 Sulfatases signature 1 and PS01095 Chitinases family 18 active site signature. BELONGS TO THE SULFATASE FAMILY. Q7TWS6 No NC_002945.3 Mycobrowser_v2 CDS 3640508 3641425 . - 0 Mb3328c CONSERVED HYPOTHETICAL PROTEIN Mb3328c, -, len: 305 aa. Equivalent to Rv3300c,len: 305 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 305 aa overlap). Conserved hypothetical protein, similar to various proteins (notably pseudoridine synthase family proteins) e.g. Q9RJ76|SCI41.08 PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 876, E(): 4.5e-48,(52.1% identity in 313 aa overlap); Q9I272|PA2043 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa),FASTA scores: opt: 676, E(): 1.8e-35, (42.55% identity in 268 aa overlap); Q9JZW8|NMB0867 YABO/YCEC/SFHB FAMILY PROTEIN from Neisseria meningitidis (serogroup B) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q9JUY2|NMA1085 HYPOTHETICAL PROTEIN from Neisseria meningitidis (serogroup A) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q12362|RIB2_YEAST|RIB2|YOL066C DRAP DEAMINASE (PSEUDOURIDINE SYNTHASE FAMILY PROTEIN) from Saccharomyces cerevisiae (Baker's yeast) (591 aa), FASTA scores: opt: 338, E(): 6.9e-14, (32.95% identity in 246 aa overlap); Q9RTS2|DR1684 PUTATIVE PSEUDOURIDINE SYNTHASE from Deinococcus radiodurans (321 aa), FASTA scores: opt: 319,E(): 6.5e-13, (32.75% identity in 235 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308 aa) (28.8% identity in 299 aa overlap). Q7TWS5 No conserved hypotheticals Rv3300c NC_002945.3 Mycobrowser_v2 CDS 3641437 3642102 . - 0 Mb3329c phoY1 PROBABLE PHOSPHATE-TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PHOU HOMOLOG 1 PHOY1 Mb3329c, phoY1, len: 221 aa. Equivalent to Rv3301c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable phoY1,phosphate-transport system regulatory protein, highly similar to Q50047|phoY|PHOU1|PHOY1|ML2188 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 1 from Mycobacterium leprae (222 aa), FASTA scores: opt: 929, E(): 7.8e-51,(61.45% identity in 218 aa overlap). Also highly similar to Q9FCE2|2SCD46.42c PUTATIVE REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (123 aa), FASTA scores: opt: 324, E(): 1.8e-13, (43.65% identity in 103 aa overlap); Q9L0R3|SCD8A.01c PUTATIVE PHOSPHATE TRANSPORT SYSTEM REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (139 aa), FASTA scores: opt: 309, E(): 1.7e-12,(36.7% identity in 139 aa overlap); Q52989|PHOU_RHIME PHOSPHATE TRANSPORT SYSTEM PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (237 aa), FASTA scores: opt: 292,E(): 3.1e-11, (26.3% identity in 213 aa overlap); etc. And highly similar to Mycobacterium tuberculosis O53833|PHU2_MYCTU|MTV043_13c|PHOU2|PHOY2|Rv0821c|MT0843 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (213 aa) (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY. X2BP11,P65719 No NC_002945.3 Mycobrowser_v2 CDS 3642210 3643967 . - 0 Mb3330c glpD2 PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLPD2 Mb3330c, glpD2, len: 585 aa. Equivalent to Rv3302c,len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 585 aa overlap). Probable glpd2,glycerol-3-phosphate dehydrogenase (EC 1.1.99.5),equivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 GLYCEROL-3-PHOSPHATE DEHYDROGENASE (EC 1.1.99.5) from Mycobacterium leprae (585 aa), FASTA scores: opt: 3489,E(): 2.2e-198, (90.75% identity in 584 aa overlap). Also highly similar to many e.g. Q9L0I3|SCD63.06 from Streptomyces coelicolor (568 aa), FASTA scores: opt: 2203,E(): 1.6e-122, (59.95% identity in 564 aa overlap); Q9RVK8|DR1019 from Deinococcus radiodurans (522 aa), FASTA scores: opt: 949, E(): 1.4e-48, (37.0% identity in 538 aa overlap); BAB53412|MLR7270 from Rhizobium loti (Mesorhizobium loti) (505 aa), FASTA scores: opt: 861,E(): 2.2e-43, (37.3% identity in 488 aa overlap); P18158|GLPD_BACSU from B. subtilis (555 aa), FASTA scores: opt: 768, E(): 7.2e-38, (32.85% identity in 484 aa overlap); etc. Also similar to Mycobacterium tuberculosis protein Q10502|GLPD_MYCTU|MTCY427_31c|Rv2249c GLYCEROL-3-PHOSPHATE DEHYDROGENASE (516 aa), FASTA scores: opt: 843, E(): 2.6e-42, (36.5% identity in 515 aa overlap). Contains PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. COFACTOR: FAD (BY SIMILARITY). BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY. X2BMT2,P64185 No NC_002945.3 Mycobrowser_v2 CDS 3655612 3656709 . - 0 Mb3342c add PROBABLE ADENOSINE DEAMINASE ADD (ADENOSINE AMINOHYDROLASE) Mb3342c, add, len: 365 aa. Equivalent to Rv3313c,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 365 aa overlap). Probable add,adenosine deaminase (EC 3.5.4.4), equivalent to Q9CCL9|ADD|ML0700 PUTATIVE ADENOSINE DEAMINASE from Mycobacterium leprae (362 aa), FASTA scores: opt: 2097,E(): 1.4e-127, (88.2% identity in 356 aa overlap) . Also similar to many e.g. Q9AK25|2SCK8.27 from Streptomyces coelicolor (396 aa), FASTA scores: opt: 1578, E(): 3.7e-94, (66.65% identity in 360 aa overlap); Q17747|C06G3.5 from Caenorhabditis elegans (349 aa), FASTA scores: opt: 435, E(): 1.1e-20, (29.6% identity in 348 aa overlap); P22333|ADD_ECOLI|B1623 from Escherichia coli strain K12 (333 aa), FASTA scores: opt: 380, E(): 3.7e-17,(29.4% identity in 340 aa overlap); etc. BELONGS TO THE ADENOSINE AND AMP DEAMINASES FAMILY. X2BN49,P63908 No NC_002945.3 Mycobrowser_v2 CDS 3644048 3645463 . - 0 Mb3331c lpdA nad(p)h quinone reductase lpda Mb3331c, lpdA, len: 471 aa. Equivalent to Rv3303c,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 471 aa overlap). Probable lpdA,dihydrolipoamide dehydrogenase (EC 1.8.1.4), similar to other e.g. Q9EWV3|2SCK31.22c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1420,E(): 2.4e-77, (54.9% identity in 471 aa overlap); Q9A7J2|CC1731 LIPOAMIDE DEHYDROGENASE (E3 COMPONENT,PYRUVATE DEHYDROGENASE COMPLEX) from Caulobacter crescentus (466 aa), FASTA scores: opt: 696, E(): 3.6e-34,(29.6% identity in 463 aa overlap); Q04829|LPD|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE from Halobacterium volcanii (Haloferax volcanii) (474 aa), FASTA scores: opt: 675,E(): 6.5e-33, (29.3% identity in 471 aa overlap); P50970|DLDH_ZYMMO|LPD DIHYDROLIPOAMIDE DEHYDROGENASE from Zymomonas mobilis, FASTA scores: opt: 658, E(): 6.6e-32,(30.4% identity in 464 aa overlap); etc. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD (BY SIMILARITY). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation due to a single base transversion (c-a) results in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (471 aa versus 493 aa). Q7TWS4 No NC_002945.3 Mycobrowser_v2 CDS 3646164 3647333 . - 0 Mb3333c amiA1 possible n-acyl-l-amino acid amidohydrolase amia1 (n-acyl-l-amino acid aminohydrolase) Mb3333c, amiA1, len: 389 aa. Equivalent to Rv3305c,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 389 aa overlap). Possible amiA1,N-acyl-L-amino acid amidohydrolase (or peptidase) (EC 3.5.1.-), similar to many proteins e.g. Q9AK43|2SCK8.09 PUTATIVE PEPTIDASE from Streptomyces coelicolor (410 aa),FASTA scores: opt: 1015, E(): 3.9e-54, (50.8% identity in 374 aa overlap); Q9UZ30|PAB0873 AMINO ACID AMIDOHYDROLASE from Pyrococcus abyssi (383 aa), FASTA scores: opt: 823,E(): 1.6e-42, (38.2% identity in 369 aa overlap); O58453|PH0722 LONG HYPOTHETICAL AMINO ACID AMIDOHYDROLASE from Pyrococcus horikoshii (388 aa), FASTA scores: opt: 815, E(): 4.8e-42, (38.75% identity in 369 aa overlap); O34980|YTNL_BACSU HYPOTHETICAL 45.2 KDA PROTEIN from B. subtilis (416 aa), FASTA scores: opt: 805, E(): 2.1e-41,(37.85% identity in 367 aa overlap); Q9KCF8|BH1613 N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Bacillus halodurans (404 aa), FASTA scores: opt: 795, E(): 8.1e-41,(37.7% identity in 382 aa overlap); BAB50445|MLR3583 HYPOTHETICAL HIPPURATE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (387 aa), FASTA scores: opt: 761,E(): 8.9e-39, (37.65% identity in 385 aa overlap); Q9RXH4|DR0339 PUTATIVE N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Deinococcus radiodurans (392 aa), FASTA scores: opt: 745, E(): 8.4e-38, (36.15% identity in 379 aa overlap); etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. Note that previously known as amiA. Q7TWS2 No NC_002945.3 Mycobrowser_v2 CDS 3647330 3648514 . - 0 Mb3334c amiB1 probable amidohydrolase amib1 (aminohydrolase) Mb3334c, amiB1, len: 394 aa. Equivalent to Rv3306c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 394 aa overlap). Probable amiB1,aminohydrolase (EC 3.5.1.-), similar to several belonging to peptidase family M40 (and to hypothetical proteins) e.g. P54983|AMHX_BACSU AMIDOHYDROLASE AMHX from Bacillus subtilis (EC 3.5.1.-) (389 aa), FASTA scores: opt: 286,E(): 9.9e-10, (26.6% identity in 351 aa overlap); P76052|ABGB_ECOLI Aminobenzoyl-glutamate utilizatio from Escherichia coli (481 aa), FASTA scores: opt: 383, E(): 2.1e-15, (30.5% identity in 328 aa overlap); P44765|YDAJ_HAEIN HYPOTHETICAL PROTEIN HI0584 from Haemophilus influenzae (423 aa), FASTA scores: opt: 297,E(): 2.4e-10, (29.6% identity in 274 aa overlap). Note that previously known as amiB. Q7TWS1 No NC_002945.3 Mycobrowser_v2 CDS 3648579 3649385 . + 0 Mb3335 deoD PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE DEOD (INOSINE PHOSPHORYLASE) (PNP) Mb3335, deoD, len: 268 aa. Equivalent to Rv3307,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Probable deoD (alternate gene name: punA), purine nucleoside phosphorylase (EC 2.4.2.1), similar to others especially P46862|PUNA_MYCLE|DEOD_MYCLE|ML0707|L308_F2_56 from M. leprae (268 aa), FASTA scores: opt: 1373, E(): 1.5e-74,(82.05% identity in 262 aa overlap); Q9EWV2|2SCK31.24 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 1026,E(): 6.4e-54, (60.5% identity in 266 aa overlap); P81989|PUNA_CELSP from Cellulomonas sp (282 aa), FASTA scores: opt: 963, E(): 3.6e-50, (58.9% identity in 270 aa overlap); Q9X1T2|TM1596 from Thermotoga maritima (265 aa),FASTA scores: opt: 584, E(): 1.1e-27, (39.55% identity in 263 aa overlap); etc. BELONGS TO THE PNP/MTAP FAMILY 2 OF PHOSPHORYLASES. X2BMT9,P0A539 No intermediary metabolism and respiration Rv3307 NC_002945.3 Mycobrowser_v2 CDS 3649389 3650993 . + 0 Mb3336 pmmB PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE) Mb3336, pmmB, len: 534 aa. Equivalent to Rv3308,len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 534 aa overlap). Probable pmmB,phosphomannomutase (EC 5.4.2.8), equivalent to Q9CCL7|PMMB|ML0706 PUTATIVE PHOSPHO-SUGAR MUTASE from Mycobacterium leprae (538 aa), FASTA scores: opt: 2681,E(): 1.4e-150, (76.95% identity in 538 aa overlap). Also similar to others e.g. Q9AD82|SCK13.08c from Streptomyces coelicolor (549 aa), FASTA scores: opt: 1378, E(): 8.9e-74, (46.7% identity in 529 aa overlap); Q9ZHL4|PMM (FRAGMENT so no homology at N-terminus for this one) from Haemophilus ducreyi (443 aa), FASTA scores: opt: 935, E(): 9.6e-48, (39.4% identity in 449 aa overlap); P18159|YHXB_BACSU from Bacillus subtilis (565 aa), FASTA scores: opt: 776, E(): 2.7e-38, (31.7% identity in 574 aa overlap); etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. Q7TWS0 No intermediary metabolism and respiration Rv3308 NC_002945.3 Mycobrowser_v2 CDS 3650995 3651711 . - 0 Mb3337c upp PROBABLE URACIL PHOSPHORIBOSYLTRANSFERASE UPP (UMP PYROPHOSPHORYLASE) (UPRTASE) (UMP DIPHOSPHORYLASE) Mb3337c, upp, len: 238 aa. Equivalent to Rv3309c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,with 5' extension identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Probable upp,uracil phosphoribosyltransferase (EC 2.4.2.9). Also similar to others e.g. P36399|UPP_STRSL from Streptococcus salivarius (209 aa),Q9A194|UPP|SPY0392 from Streptococcus pyogenes (209 aa), Q9RE01|UPP from Lactobacillus plantarum (209 aa), etc. BELONGS TO THE UPRTASE FAMILY. Mb3337c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BN45,P0A659 No NC_002945.3 Mycobrowser_v2 CDS 3651723 3652622 . + 0 Mb3338 sapm acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) Mb3338, -, len: 299 aa. Equivalent to Rv3310, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 299 aa overlap). Possible acid phosphatase (EC 3.1.3.2), similar to several fungal or bacterial acid phosphatases e.g. BAB50846|MLR4110 from Rhizobium loti (Mesorhizobium loti) (292 aa), FASTA scores: opt: 460, E(): 4.8e-22, (38.65% identity in 295 aa overlap); P34724|PHOA_ASPNG from Aspergillus niger (417 aa), FASTA scores: opt: 172, E(): 0.0013, (29.1% identity in 306 aa overlap); P08540|PHOX_KLULA from Kluyveromyces lactis (Yeast) (421 aa), FASTA scores: opt: 170, E(): 0.0018, (27.8% identity in 266 aa overlap); P37274|PHOA_PENCH from Penicillium chrysogenum (412 aa),FASTA scores: opt: 163, E(): 0.0049, (29.05% identity in 303 aa overlap); etc. Q7TWR9 No cell wall and cell processes Rv3310 NC_002945.3 Mycobrowser_v2 CDS 3652646 3653908 . + 0 Mb3339 conserved protein Mb3339, -, len: 420 aa. Equivalent to Rv3311, len: 420 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 420 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical proteins Q9CCL8|ML0703 (423 aa), FASTA scores: opt: 2185, E(): 5.5e-120, (77.55% identity in 423 aa overlap); Q49918|L308_F2_61 (167 aa), FASTA scores: opt: 929, E(): 3.5e-47, (84.4% identity in 167 aa overlap) (similarity at C-terminus for this one); and Q49914|L308_F1_17 (166 aa), FASTA scores: opt: 900, E(): 1.7e-45, (79.0% identity in 162 aa overlap) (similarity at N-terminus for this one); Q49923|U0308N (86 aa) FASTA scores: opt: 149, E(): 0.052, (48.35% identity in 60 aa overlap); etc. Note that the Rv3311 corresponding protein in Mycobacterium leprae is similar to products of two adjacent ORFs. Also some similarity to Q9XI61|F9L1.1 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (523 aa), FASTA scores: opt: 134, E(): 1.8, (25.1% identity in 203 aa overlap). Equivalent to AAK47753 from Mycobacterium tuberculosis strain CDC1551 (431 aa) but shorter 12 aa. Q7TWR8 No conserved hypotheticals Rv3311 NC_002945.3 Mycobrowser_v2 CDS 3668187 3668831 . - 0 Mb3359c HYPOTHETICAL PROTEIN Mb3359c, -, len: 214 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but similar to 3' end of MT3429, len: 172 aa, from Mycobacterium tuberculosis strain CDC1551, (100% identity in 172 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv. Q7TWQ2 No NC_002945.3 Mycobrowser_v2 CDS 3653929 3654855 . - 0 Mb3340c CONSERVED HYPOTHETICAL PROTEIN Mb3340c, -, len: 308 aa. Equivalent to Rv3312c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Hypothetical protein,similar to various proteins (principally hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (326 aa), FASTA scores: opt: 261, E(): 2.6e-09, (27.55% identity in 323 aa overlap); Q9FWB6 PUTATIVE ALPHA/BETA HYDROLASE from Oryza sativa (Rice) (354 aa), FASTA scores: opt: 241, E(): 4.9e-08, (28.9% identity in 301 aa overlap) (note that Q9FWB6 correspond to Q9FWB5 PUTATIVE ALPHA/BETA HYDROLASE (353 aa) but longer 1 aa; and to Q9AUW9 HYPOTHETICAL PROTEIN (332 aa) but longer 22 aa); Q9M382|F24B22.200 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (342 aa), FASTA scores: opt: 222, E(): 8e-07, (27.6% identity in 319 aa overlap); Q9HWM9|PA4152 PROBABLE HYDROLASE from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 176, E(): 0.00071,(29.2% identity in 209 aa overlap); Q9L3R2 HYDROLASE from Rhizobium leguminosarum (261 aa), FASTA scores: opt: 174,E(): 0.00071, (28.9% identity in 173 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) from Streptomyces lividans (275 aa), FASTA scores: opt: 172, E(): 0.001, (30.9% identity in 194 aa overlap) (similarity only at N-terminus for this one); etc. Some similarity in N-terminal part to non-heme chloroperoxidases. Also similar to O05293|Rv1191|MTCI364.03 HYPOTHETICAL PROTEIN from M. tuberculosis (304 aa), FASTA scores: opt: 417, E(): 3.1e-19, (32.6% identity in 279 aa overlap) (note that Rv1191 is equivalent to AAK45485 from Mycobacterium tuberculosis strain CDC1551 but shorter 14 aa, and that AAK45485 is annoted Hydrolase, alpha/beta hydrolase family). Q7TWR7 No conserved hypotheticals Rv3312c NC_002945.3 Mycobrowser_v2 CDS 3664237 3664770 . - 0 Mb3353c moaC3 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 3 MOAC3 Mb3353c, moaC3, len: 177 aa. Equivalent to Rv3324c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). Probable moaC3,molybdopterin cofactor biosynthesis protein, highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa), FASTA scores: opt: 567, E(): 7.5e-30,(58.35% identity in 156 aa overlap); Q9RKA8|MOAC from Streptomyces coelicolor (170 aa), FASTA scores: opt: 553,E(): 6.3e-29, (58.25% identity in 158 aa overlap); P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa), FASTA scores: opt: 516, E(): 1.5e-26,(55.95% identity in 159 aa overlap); etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 734, E(): 1.3e-40, (71.8% identity in 163 aa overlap); and Rv0864|MOAC2|MTV043.57 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN (167 aa). X2BNL6,P65393 No NC_002945.3 Mycobrowser_v2 CDS 3656709 3657992 . - 0 Mb3343c deoA PROBABLE THYMIDINE PHOSPHORYLASE DEOA (TDRPASE) (PYRIMIDINE PHOSPHORYLASE) Mb3343c, deoA, len: 427 aa. Equivalent to Rv3314c,len: 427 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 427 aa overlap). Probable deoA,thymidine phosporylase (EC 2.4.2.4), highly similar to many e.g. Q9AK36|DEOA from Streptomyces coelicolor (427 aa), FASTA scores: opt: 1668, E(): 3.2e-90, (62.35% identity in 425 aa overlap); Q9CFM5|PDP from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (430 aa),FASTA scores: opt: 1031, E(): 5.5e-53, (46.45% identity in 392 aa overlap); P19971|TYPH_HUMAN|ECGF1 from Homo sapiens (Human) (482 aa), FASTA scores: opt: 957, E(): 1.3e-48,(44.45% identity in 441 aa overlap); P07650|TYPH_ECOLI|DEOA|TPP|TTG|B4382 from Escherichia coli strain K12 (440 aa), FASTA scores: opt: 847, E(): 3.2e-42,(41.55% identity in 438 aa overlap); etc. Contains PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. BELONGS TO THE THYMIDINE/PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASES FAMILY. Q7TWR5 No NC_002945.3 Mycobrowser_v2 CDS 3657989 3658390 . - 0 Mb3344c cdd PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) Mb3344c, cdd, len: 133 aa. Equivalent to Rv3315c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable cdd,cytidine deaminase (EC 3.5.4.5), equivalent to Q9CBD3|CDD|ML2174 CYTIDINE DEAMINASE from Mycobacterium leprae (134 aa), FASTA scores: opt: 516, E(): 5.8e-28,(56.8% identity in 132 aa overlap). Also highly similar to many e.g. Q9AK37|2SCK8.15 from Streptomyces coelicolor (130 aa), FASTA scores: opt: 523, E(): 1.9e-28, (60.0% identity in 130 aa overlap); Q9KD53|CDD|BH1366 from Bacillus halodurans (132 aa), FASTA scores: opt: 305, E(): 9.2e-14, (41.55% identity in 130 aa overlap); P56389|CDD_MOUSE|CDA|CDD from Mus musculus (Mouse) (146 aa), FASTA scores: opt: 287, E(): 1.6e-12, (40.3% identity in 124 aa overlap); P19079|CDD_BACSU (136 aa), FASTA scores: opt: 270, E(): 2.1e-11, (28.6% identity in 127 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. COFACTOR: ZINC (BY SIMILARITY). Q7TWR4 No NC_002945.3 Mycobrowser_v2 CDS 3662596 3662838 . - 0 Mb3350c vapb44 possible antitoxin vapb44 Mb3350c, -, len: 80 aa. Equivalent to Rv3321c, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Conserved hypothetical protein, similar at N-terminal region to several proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. AAK48167|MT3800 DNA-BINDING PROTEIN (COPG FAMILY) from strain CDC1551 (74 aa), FASTA scores: opt: 142, E(): 0.0016, (48.85% identity in 43 aa overlap); AAK46916|MT2606 HYPOTHETICAL 8.0 KDA PROTEIN from strain CDC1551 (74 aa), FASTA scores: opt: 139, E(): 0.0026,(37.2% identity in 78 aa overlap); O50456|Rv1241|MTV006.13 HYPOTHETICAL 9.9 KDA PROTEIN from strain H37Rv (86 aa),FASTA scores: opt: 134, E(): 0.0066, (39.0% identity in 82 aa overlap); etc. Q7TWQ8 No virulence, detoxification, adaptation Rv3321c NC_002945.3 Mycobrowser_v2 CDS 3666685 3667071 . + 0 Mb3357 HYPOTHETICAL PROTEIN [SECOND PART] Mb3357, -, len: 128 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but similar to 3' end of a hypothetical CDS, len: 237 aa, from Mycobacterium tuberculosis strain F4, (100.0% identity in 109 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv. Q7TWQ4 No NC_002945.3 Mycobrowser_v2 CDS 3658627 3658965 . + 0 Mb3345 sdhC PROBABLE SUCCINATE DEHYDROGENASE (CYTOCHROME B-556 SUBUNIT) SDHC (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) Mb3345, sdhC, len: 112 aa. Equivalent to Rv3316,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Probable sdhC,cytochrome B-556 of succinate dehydrogenase SdhC subunit (EC 1.3.99.1), transmembrane protein, equivalent (but shorter 35 aa) to Q9CCM0|SDHC|ML0699 PUTATIVE SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT from Mycobacterium leprae (153 aa), FASTA scores: opt: 692, E(): 1.2e-39,(88.4% identity in 112 aa overlap). Also similar to others e.g. Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126 aa), FASTA scores: opt: 484, E(): 8.3e-26, (65.65% identity in 99 aa overlap); Q9RVR8|DR0954 from Deinococcus radiodurans (118 aa), FASTA scores: opt: 195, E(): 1.7e-06, (36.8% identity in 87 aa overlap); Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium sp. strain NRC-1 (130 aa), FASTA scores: opt: 192, E(): 2.9e-06, (37.85% identity in 74 aa overlap); P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis (Natronobacterium pharaonis) (130 aa), FASTA scores: opt: 183, E(): 1.1e-05, (35.15% identity in 74 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. BELONGS TO THE CYTOCHROME B560 FAMILY. Q7TWR3 No intermediary metabolism and respiration Rv3316 NC_002945.3 Mycobrowser_v2 CDS 3658962 3659396 . + 0 Mb3346 sdhD PROBABLE SUCCINATE DEHYDROGENASE (HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT) SDHD (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) Mb3346, sdhD, len: 144 aa. Equivalent to Rv3317,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 144 aa overlap). Probable sdhD,membrane anchor of succinate dehydrogenase SdhD subunit (EC 1.3.99.1), equivalent (but shorter 19 aa) to Q49915|SDHD|ML0698|L308_F1_25 PUTATIVE SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN from Mycobacterium leprae (163 aa), FASTA scores: opt: 878,E(): 1.9e-51, (85.2% identity in 142 aa overlap). Also similar to others e.g. Q9KZ89|SC5G8.25c from Streptomyces coelicolor (160 aa), FASTA scores: opt: 553, E(): 6.6e-30,(58.85% identity in 141 aa overlap); Q9RVR9|DR0953 from Deinococcus radiodurans (125 aa), FASTA scores: opt: 251,E(): 5.5e-10, (37.15% identity in 113 aa overlap); O29573|DHSD_ARCFU|SDHD|AF0684 from Archaeoglobus fulgidus (117 aa), FASTA scores: opt: 160, E(): 0.00056, (25.95% identity in 108 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. Q7TWR2 No intermediary metabolism and respiration Rv3317 NC_002945.3 Mycobrowser_v2 CDS 3664767 3665141 . - 0 Mb3354c moaB3 PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB3 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD) Mb3354c, moaB3, len: 124 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT3426, len: 124 aa, from Mycobacterium tuberculosis strain CDC1551, (100.000% identity in 124 aa overlap). Probable moaB3, pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), similar to others e.g. MOAB1|Rv3110|MT3193|MTCY164.20 PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis strain H37Rv (142 aa), FASTA scores: opt: 383, E(): 1.2e-21, (50.000% identity in 110 aa overlap); Q96YL0|STS230 PUTATIVE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Sulfolobus tokodaii (93 aa), FASTA scores: opt: 208, E(): 1.5e-08,(37.500% identity in 88 aa overlap); Q8YNL6|ASR4549 PTERIN-4A-CARBINOLAMINE DEHYDRATASE from Anabaena sp. strain PCC 7120 (93 aa), FASTA scores: opt: 179, E(): 2.2e-06, (37.363% identity in 91 aa overlap); P73790|PHS_SYNY3|SSL2296 PUTATIVE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Synechocystis sp. strain PCC 6803 (96 aa), FASTA scores: opt: 175, E(): 4.6e-06, (33.7% identity in 92 aa overlap); etc. BELONGS TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv. Q7TTP5 No NC_002945.3 Mycobrowser_v2 CDS 3659525 3661297 . + 0 Mb3347 sdhA PROBABLE SUCCINATE DEHYDROGENASE (FLAVOPROTEIN SUBUNIT) SDHA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) Mb3347, sdhA, len: 590 aa. Equivalent to Rv3318,len: 590 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 590 aa overlap). Probable sdhA,flavoprotein of succinate dehydrogenase SdhA subunit (EC 1.3.99.1), equivalent to Q9CCM1|SDHA|ML0697 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT from Mycobacterium leprae (584 aa), FASTA scores: opt: 3657, E(): 1.2e-217,(92.55% identity in 590 aa overlap). Also highly similar to others e.g. Q9KZ90|DHSA from Streptomyces coelicolor (584 aa), FASTA scores: opt: 2813, E(): 1.1e-165, (70.5% identity in 586 aa overlap); Q9RVS0|DR0952 from Deinococcus radiodurans (583 aa), FASTA scores: opt: 2203,E(): 4.1e-128, (57.35% identity in 593 aa overlap); P31038|DHSA_RICPR|SDHA|RP128 from Rickettsia prowazekii (596 aa), FASTA scores: opt: 1892, E(): 5.8e-109, (50.0% identity in 588 aa overlap); P10444|DHSA_ECOLI|SDHA|B0723|Z0877|ECS0748 from Escherichia coli strains K12 and O157:H7 (588 aa), FASTA scores: opt: 1844, E(): 5.2e-106, (48.75% identity in 591 aa overlap); etc. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. COFACTOR: FAD. SIMILAR TO THE FLAVOPROTEIN SUBUNITS OF OTHER SPECIES SUCCINATE DEHYDROGENASE AND OF FUMARATE REDUCTASE. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. Q7TWR1 No intermediary metabolism and respiration Rv3318 NC_002945.3 Mycobrowser_v2 CDS 3661297 3662088 . + 0 Mb3348 sdhB PROBABLE SUCCINATE DEHYDROGENASE (IRON-SULPHUR PROTEIN SUBUNIT) SDHB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) Mb3348, sdhB, len: 263 aa. Equivalent to Rv3319,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Probable sdhB,iron-sulphur protein succinate dehydrogenase SdhB subunit (EC 1.3.99.1), equivalent to Q49916|SDHB|ML0696|L308_F1_28 SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1678,E(): 4.7e-99, (89.8% identity in 264 aa overlap). Also highly similar to other e.g. Q9KZ91|DHSB from Streptomyces coelicolor (257 aa), FASTA scores: opt: 1125, E(): 4.6e-64, (64.1% identity in 262 aa overlap); Q9RVS1|DR0951 from Deinococcus radiodurans (264 aa), FASTA scores: opt: 1014, E(): 5e-57, (57.25% identity in 255 aa overlap); Q9PEF5|XF1073 from Xylella fastidiosa (261 aa), FASTA scores: opt: 681, E(): 5.8e-36, (45.1% identity in 244 aa overlap); P07014|DHSB_ECOLI|SDHB|B0724 from Escherichia coli strain K12 (238 aa), FASTA scores: opt: 657, E(): 1.8e-34, (43.75% identity in 240 aa overlap); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. COFACTOR: BINDS THREE DIFFERENT IRON-SULFUR CLUSTERS: A 2FE-2S, A 3FE-4S AND A 4FE-4S. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'PLANT-TYPE' 2FE-2S AND 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN,AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. Q7TWR0 No intermediary metabolism and respiration Rv3319 NC_002945.3 Mycobrowser_v2 CDS 3666947 3668092 . + 0 Mb3358 embR2 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR2 Mb3358, embR2, len: 381 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT3428, len: 381 aa, from Mycobacterium tuberculosis strain CDC1551, (100.000% identity in 381 aa overlap). Possible embR2, transcriptional regulatory protein, highly similar to other mycobacteria EmbR proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15|EMBR PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR from Mycobacterium tuberculosis (388 aa), FASTA scores: opt: 1420, E(): 7.3e-84, (57.3% identity in 370 aa overlap); P71484|EMBR EMBR PROTEIN from Mycobacterium avium (384 aa) (see citation below), FASTA scores: opt: 1338, E(): 1.4e-78,(53.65% identity in 384 aa overlap); and also O05797|Rv3124|MT3208|MTCY164.34 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (311 aa), FASTA scores: opt: 928, E(): 3e-52, (53.75% identity in 255 aa overlap). Also similar to other transcriptional regulatory proteins from other organisms e.g. Q9XCC3|TYLT HYPOTHETICAL PATHWAY SPECIFIC REGULATORY PROTEIN from Streptomyces fradiae (404 aa), FASTA scores: opt: 506,E(): 5.7e-25, (38.153% identity in 249 aa overlap); etc. BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv. Q7TWQ3 No NC_002945.3 Mycobrowser_v2 CDS 3662960 3663574 . - 0 Mb3351c POSSIBLE METHYLTRANSFERASE Mb3351c, -, len: 204 aa. Equivalent to Rv3322c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Conserved hypothetical protein, showing weak similarity to proteins including several methyltransferases (EC 2.1.1.-) e.g. Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (208 aa), FASTA scores: opt: 193, E(): 1e-05,(36.35% identity in 132 aa overlap); and Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 161, E(): 0.0014, (32.05% identity in 131 aa overlap); P74712|SLR1183 HYPOTHETICAL 21.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (194 aa), FASTA scores: opt: 155, E(): 0.0032, (27.35% identity in 150 aa overlap); Q9ABW8|CC0102 RRNA METHYLTRANSFERASE RSMB from Caulobacter crescentus (429 aa), FASTA scores: opt: 148, E(): 0.018, (31.5% identity in 162 aa overlap); etc. Also highly similar to O05796|Rv3120|MTCY164.30 HYPOTHETICAL 21.8 KDA PROTEIN from Mycobacterium tuberculosis (200 aa), FASTA scores: opt: 691, E(): 1.2e-38, (56.5% identity in 200 aa overlap); and shows weak similarity to O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE from Mycobacterium tuberculosis (233 aa), FASTA scores: opt: 155, E(): 0.0037, (29.15% identity in 168 aa overlap). Q7TWQ7 No intermediary metabolism and respiration Rv3322c NC_002945.3 Mycobrowser_v2 CDS 3663571 3664236 . - 0 Mb3352c moaX PROBABLE MOAD-MOAE FUSION PROTEIN MOAX Mb3352c, moaX, len: 221 aa. Equivalent to Rv3323c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable moaX,MoaD-MoaE fusion protein, similar (whole or partial) to several MoaD and MoaE proteins e.g. Q9RR88|DR2607 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D/E from Deinococcus radiodurans (229 aa), FASTA scores: opt: 407,E(): 1.8e-18, (32.75% identity in 223 aa overlap); Q9K8I7|MOAE|BH3019 MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus halodurans (156 aa), FASTA scores: opt: 375, E(): 1.3e-16, (41.65% identity in 132 aa overlap); O31705|MOAE MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus subtilis (157 aa), FASTA scores: opt: 368, E(): 3.6e-16, (41.65% identity in 132 aa overlap); etc. C-terminus highly similar to O05795|MOAE_MYCTU|Rv3119|MT3201|MTCY164.29|MOAE1 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 733, E(): 5.4e-39, (76.2% identity in 143 aa overlap); and N-terminus highly similar to O05789|MOAD1|Rv3112|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 333, E(): 3.2e-14, (65.05% identity in 83 aa overlap). Q7TWQ6 No NC_002945.3 Mycobrowser_v2 CDS 3686614 3690630 . - 0 Mb3375c PPE54 ppe family protein ppe54 Mb3375c, PPE54, len: 1338 aa. Similar to 3' end of Rv3343c, len: 2523 aa, from Mycobacterium tuberculosis strain H37Rv, (98.6% identity in 1151 aa overlap). Member of the Mycobacterium tuberculosis PPE family, MPTR subgroup of Gly-, Asn-rich proteins. Most similar to O50379|Rv3350c|MTV004.07c|MTV004_5 from Mycobacterium tuberculosis strain H37Rv (3716 aa), FASTA scores: opt: 4672, E(): 4e-211, (44.2% identity in 3174 aa overlap); and also similar to MTV004_3, MTCY63_9, MTY13E10_17,MTY13E10_16, MTCY180_1, MTV050_1, MTCY3C7_23, MTV014_3,MTCY63_10; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3555 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7TWP0 No NC_002945.3 Mycobrowser_v2 CDS 3665238 3666302 . - 0 Mb3355c moaA3 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1 Mb3355c, moaA3, len: 354 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT3427|MOAA3, len: 378 aa, from Mycobacterium tuberculosis strain CDC1551, (100.000% identity in 354 aa overlap). Probable moaA3, molybdenum cofactor biosynthesis protein,similar to others e.g. O05786|MOA1_MYCTU|MOAA1|MOAA|Rv3109|MT3192|MTCY164.19 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Mycobacterium tuberculosis strain H37Rv (359 aa), FASTA scores: opt: 1762, E(): 3.7e-108, (74.3% identity in 350 aa overlap); Q99S04|MOAA|SA2063 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Staphylococcus aureus strain N315 (340 aa), FASTA scores: opt: 819, E(): 3.2e-46,(38.25% identity in 324 aa overlap); O67929|MOAA_AQUAE|AQ_2183 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Aquifex aeolicus (320 aa), FASTA scores: opt: 815, E(): 5.6e-46, (41.8% identity in 323 aa overlap); etc. BELONGS TO THE MOAA/NIFB/PQQE FAMILY. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv. X2BMW0,P62588 No NC_002945.3 Mycobrowser_v2 CDS 3666357 3666707 . + 0 Mb3356 HYPOTHETICAL PROTEIN [FIRST PART] Mb3356, -, len: 116 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but similar to 5' end of a hypothetical CDS, len: 237 aa, from Mycobacterium tuberculosis strain F4, (100.0% identity in 109 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv. Q7TWQ5 No NC_002945.3 Mycobrowser_v2 CDS 3668998 3670710 . + 0 Mb3360 PROBABLE TRANSPOSASE FUSION PROTEIN Mb3360, -, len: 570 aa. Equivalent to Rv3327, len: 570 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 570 aa overlap). Probable fusion protein. Indeed, N-terminal part corresponds to entire O07269 transposase of IS1547 (383 aa), and C-terminal part identical to MTCI249B.03c (210 aa). N-terminal part is identical to MTV042_7 (188 aa); C-terminal part (aa 378-570) is similar to hypothetical 20.5 KD protein from Escherichia coli P76222|YNJA_ECOLI (182 aa), FASTA scores: opt: 292, E(): 5.3e-11, (32.6% identity in 181 aa overlap). Q7TWQ1 No insertion seqs and phages Rv3327 NC_002945.3 Mycobrowser_v2 CDS 3709479 3713138 . - 0 Mb3383c PPE56d PPE FAMILY PROTEIN [THIRD PART] Mb3383c, PPE56d, len: 1219 aa. Equivalent to 3' end of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 1219 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10,MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d. No NC_002945.3 Mycobrowser_v2 CDS 3670643 3671581 . - 0 Mb3361c sigJ PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR (FRAGMENT) SIGJ Mb3361c, sigJ, len: 312 aa. Equivalent to Rv3328c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 312 aa overlap). Probable sigJ,alternative RNA polymerase sigma factor (see citation below), highly similar to many e.g. Q9K3H7|2SCG18.10c from Streptomyces coelicolor (295 aa), FASTA scores: opt: 642,E(): 7.3e-31, (42.8% identity in 292 aa overlap); Q9A3D8|CC3266 from Caulobacter crescentus (291 aa), FASTA scores: opt: 607, E(): 8.4e-29, (39.8% identity in 294 aa overlap); Q9RD74|SCF43.14c from Streptomyces coelicolor (324 aa), FASTA scores: opt: 555, E(): 1.1e-25, (41.1% identity in 297 aa overlap); etc. Similar also to U00022_20 from Mycobacterium leprae; and MTCI28_22 and MSU87307_1. Also similar to O50445|SIGI|Rv1189|MTV005.25|MTCI364.01 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 426, E(): 4.2e-18, (32.65% identity in 294 aa overlap). Equivalent to AAK47774 from Mycobacterium tuberculosis strain CDC1551 (282 aa) but longer 30 aa. Contains probable helix-turn-helix motif at aa 129-150 (Score 1126, +3.02 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Q7TWQ0 No NC_002945.3 Mycobrowser_v2 CDS 3671557 3672957 . + 0 Mb3362 PROBABLE AMINOTRANSFERASE Mb3362, -, len: 466 aa. Equivalent to hypothetical protein MT3432 from Mycobacterium tuberculosis strain CDC1551 (100% identity with 465 aa overlap). Probable aminotransferase (EC 2.6.1.-), similar to many e.g. O86744|SC6A9.12 from Streptomyces coelicolor (457 aa),Q9I6J2|PA0299 from Pseudomonas aeruginosa (456 aa),Q53196|Y4UB_RHISN from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (467 aa), P33189|YHXA_BACSU from Bacillus subtilis (450 aa) etc. COFACTOR: PYRIDOXAL PHOSPHATE. COULD BELONG TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. X2BN66 No NC_002945.3 Mycobrowser_v2 CDS 3677186 3678031 . - 0 Mb3366c HYPOTHETICAL PROLINE RICH PROTEIN Mb3366c, -, len: 281 aa. Equivalent to Rv3333c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Hypothetical unknown pro-rich protein. Equivalent to AAK47780 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa) but longer 16 aa. Q7TWP5 No conserved hypotheticals Rv3333c NC_002945.3 Mycobrowser_v2 CDS 3674339 3675847 . + 0 Mb3364 sugI PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN SUGI Mb3364, sugI, len: 502 aa. Equivalent to Rv3331,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 502 aa overlap). Probable sugI,sugar-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to several transporters e.g. P37021|GALP_ECOLI|B2943 GALACTOSE-PROTON SYMPORTER (GALACTOSE TRANSPORTER) from Escherichia coli strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39,(31.85% identity in 446 aa overlap); P96742|YWTG METABOLITE-TRANSPORT-RELATED PROTEIN from Bacillus subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39,(33.2% identity in 428 aa overlap); AAG58074|GALP (alias BAB37242|ECS3819) GALACTOSE-PROTON SYMPORT OF TRANSPORT SYSTEM from Escherichia coli strain O157:H7 EDL933 (464 aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity in 432 aa overlap); P46333|CSBC_BACSU|SS92BR PROBABLE METABOLITE TRANSPORT PROTEIN from Bacillus subtilis (461 aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from Mycobacterium tuberculosis strain CDC1551 (500 aa) but with some divergence between residues 229 and 254. Contains PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2. BELONGS TO THE SUGAR TRANSPORTER FAMILY. Q7TWP7 No cell wall and cell processes Rv3331 NC_002945.3 Mycobrowser_v2 CDS 3713132 3719266 . - 0 Mb3384c PPE56b PPE FAMILY PROTEIN [SECOND PART] Mb3384c, PPE56b, len: 2044 aa. Equivalent to middle part of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 2018 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many M. tuberculosis proteins from strains H37Rv and CDC1551,e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1,MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d. No NC_002945.3 Mycobrowser_v2 CDS 3675844 3676995 . + 0 Mb3365 nagA PROBABLE N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE NAGA (GLCNAC 6-P DEACETYLASE) Mb3365, nagA, len: 383 aa. Equivalent to Rv3332,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Probable nagA,N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25),similar to many e.g. Q9KXV7|SCD95A.17c PUTATIVE DEACETYLASE from Streptomyces coelicolor (381 aa), FASTA scores: opt: 1090, E(): 1.6e-55, (47.8% identity in 385 aa overlap); Q9PDB4|XF1465 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Xylella fastidiosa (386 aa), FASTA scores: opt: 667, E(): 3.5e-31, (38.3% identity in 394 aa overlap); Q9AAZ9|CC0443 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Caulobacter crescentus (378 aa), FASTA scores: opt: 661, E(): 7.5e-31, (38.9% identity in 383 aa overlap); O34450||NAGA_BACSU N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Bacillus subtilis (396 aa), FASTA scores: opt: 571, E(): 1.2e-25,(32.45% identity in 376 aa overlap); etc. Equivalent to AAK47778 from Mycobacterium tuberculosis strain CDC1551 (346 aa) but longer 37 aa. BELONGS TO THE NAGA FAMILY. Q7TWP6 No cell wall and cell processes Rv3332 NC_002945.3 Mycobrowser_v2 CDS 3678506 3678946 . + 0 Mb3367 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MERR-FAMILY) Mb3367, -, len: 146 aa. Equivalent to Rv3334, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Probable transcriptional regulator, similar to many regulatory proteins (notably mercury resistance operon regulators) e.g. Q9HXV1|PA3689 PROBABLE TRANSCRIPTIONAL REGULATOR MERR FAMILY from Pseudomonas aeruginosa (156 aa), FASTA scores: opt: 275, E(): 1.6e-11, (35.95% identity in 139 aa overlap); Q9AKR6|PBRR LEAD RESISTANCE OPERON REGULATOR from Ralstonia metallidurans strain CH34 (plasmid pMOL30) (145 aa), FASTA scores: opt: 267, E(): 5.2e-11, (35.8% identity in 134 aa overlap); P95838|MERR MERCURIC RESISTANCE OPERON REGULATOR from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (144 aa), FASTA scores: opt: 266, E(): 6e-11, (31.35% identity in 118 aa overlap); P22853|MERR_BACSR MERCURIC RESISTANCE OPERON REGULATOR from Bacillus sp. strain RC607 (132 aa), FASTA scores: opt: 262, E(): 1e-10, (34.6% identity in 130 aa overlap); etc. Contains probable helix-turn-helix motif at aa 1-22 (Score 1478, +4.22 SD). SEEMS TO BELONG TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TWP4 No regulatory proteins Rv3334 NC_002945.3 Mycobrowser_v2 CDS 3724571 3724828 . + 0 Mb3393 relk toxin relk Mb3393, -, len: 85 aa. Equivalent to Rv3358, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypohetical protein, highly similar to other hypohetical proteins e.g. Q9Z4V8|SCBAC17D6.03 from Streptomyces coelicolor (84 aa),FASTA scores: opt: 393, E(): 1.1e-21, (59.75% identity in 82 aa overlap); P56605|YOEB_ECOLI from Escherichia coli (84 aa), FASTA scores: opt: 305, E(): 2.2e-15, (49.35% identity in 77 aa overlap); Q9Z5W7 PUTATIVE DOC PROTEIN from Francisella novicida (68 aa), FASTA scores: opt: 253,E(): 9.6e-12, (51.6% identity in 62 aa overlap); BAB58569|SAV2407 from Staphylococcus aureus subsp. aureus Mu50 (88 aa), FASTA scores: opt: 250, E(): 2e-11, (40.5% identity in 84 aa overlap); etc. X2BNR1,P64529 No virulence, detoxification, adaptation Rv3358 NC_002945.3 Mycobrowser_v2 CDS 3678980 3679849 . - 0 Mb3368c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3368c, -, len: 289 aa. Equivalent to Rv3335c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable conserved integral membrane protein, equivalent to Q49909|ML0687 PUTATIVE MEMBRANE PROTEIN U0308AA from Mycobacterium leprae (313 aa), FASTA scores: opt: 1299, E(): 8.9e-75,(68.75% identity in 288 aa overlap). Also similar to other hypothetical bacterial proteins e.g. BAB37825|ECS4402 from Escherichia coli strain O157:H7 (alias P37642|YHJD_ECOLI|B3522 strain K12) (337 aa), FASTA scores: opt: 591, E(): 4.2e-30, (35.15% identity in 273 aa overlap); P45417|YHJD_ERWCH from Erwinia chrysanthemi (328 aa), FASTA scores: opt: 500, E(): 2.2e-24, (34.9% identity in 275 aa overlap); Q9KZA0|SC5G8.14 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (321 aa),FASTA scores: opt: 321, E(): 4.3e-13, (27.3% identity in 271 aa overlap); etc. Q7TWP3 No cell wall and cell processes Rv3335c NC_002945.3 Mycobrowser_v2 CDS 3679870 3680880 . - 0 Mb3369c trpS PROBABLE TRYPTOPHANYL-TRNA SYNTHETASE TRPS (TRYPTOPHAN--TRNA LIGASE) (TRPRS) (TRYPTOPHAN TRANSLASE) Mb3369c, trpS, len: 336 aa. Equivalent to Rv3336c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable trpS,tryptophanyl-tRNA synthetase (EC 6.1.1.2), equivalent to Q49901|SYW_MYCLE|TRPS|ML0686|L308_C1_147 TRYPTOPHANYL-TRNA SYNTHETASE from Mycobacterium leprae (343 aa), FASTA scores: opt: 1859, E(): 4.8e-107, (83.75% identity in 339 aa overlap). Also similar to many e.g. Q9KZA7|TRPS2 from Streptomyces coelicolor (339 aa), FASTA scores: opt: 1359,E(): 2.6e-76, (60.3% identity in 335 aa overlap); Q9EYY6|TRPS from Klebsiella aerogenes (334 aa), FASTA scores: opt: 1077, E(): 5.5e-59, (52.15% identity in 328 aa overlap); P00954|SYW_ECOLI|TRPS|B3384 from Escherichia coli strain K12 (334 aa), FASTA scores: opt: 1074, E(): 8.3e-59, (51.85% identity in 328 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. X2BP70,P67591 No NC_002945.3 Mycobrowser_v2 CDS 3727100 3727681 . - 0 Mb3397c PROBABLE ATP/GTP-BINDING PROTEIN Mb3397c, -, len: 193 aa. Equivalent to Rv3362c,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 193 aa overlap). Probable ATP/GTP-binding protein, similar to others from Streptomyces coelicolor e.g. O86519|SC1C2.18c (174 aa),FASTA scores: opt: 731, E(): 9.8e-41, (66.85% identity in 169 aa overlap); Q9XAE1|SC6G9.41c (191 aa), FASTA scores: opt: 730, E(): 1.2e-40, (63.55% identity in 173 aa overlap); Q9L235|SC1A2.06 (184 aa), FASTA scores: opt: 650, E(): 1.9e-35, (55.95% identity in 177 aa overlap); Q9RJ74|SCI41.10c (176 aa), FASTA scores: opt: 618, E(): 2.3e-33, (55.9% identity in 161 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TWM6 No conserved hypotheticals Rv3362c NC_002945.3 Mycobrowser_v2 CDS 3680905 3681798 . + 0 Mb3370 CONSERVED HYPOTHETICAL PROTEIN Mb3370, -, len: 297 aa. Equivalent to Rv3337 and Rv3338, len: 128 aa and 214 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 81 aa overlap and 100.0% identity in 214 aa overlap). Rv3337: Conserved hypothetical protein, equivalent to N-terminus of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: *****opt: 362, E(): 3e-17, (74.3% identity in 70 aa overlap). Also weak similarity in N-terminus to BAB49078|MLR1789 PROBABLE EPOXIDE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (300 aa), FASTA scores: opt: 116, E(): 0.74, (38.9% identity in 54 aa overlap). Homology suggests this ORF should be in frame with the following ORF MTV016.38 but no sequence error could be found. Short distance to start of trpS suggests region may not be protein-coding. C-terminus extended since first submission (+47 aa). Rv3338: Hypothetical protein, equivalent to C-termini of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: opt: 984, E(): 2.6e-56,(65.4% identity in 214 aa overlap); and O32873|MLCB1779.02 HYPOTHETICAL 31.8 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (292 aa), FASTA scores: opt: 984, E(): 2.5e-56, (65.4% identity in 214 aa overlap). Also similar to C-termini of several hypothetical proteins (generally hydrolases) e.g. Q9K3H6|2SCG18.11 PUTATIVE HYDROLASE from Streptomyces coelicolor (316 aa), FASTA scores: opt: 213, E(): 1.4e-06,(29.75% identity in 185 aa overlap). Homology suggests that this ORF should be in frame with the previous ORF MTV016.37 but no sequence error could be found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base insertion (*-t) leads to a single product. Q7TWP2 No conserved hypotheticals Rv3337 NC_002945.3 Mycobrowser_v2 CDS 4050868 4051689 . - 0 Mb3696c CONSERVED HYPOTHETICAL PROTEIN Mb3696c, -, len: 273 aa. Equivalent to Rv3672c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Conserved hypothetical protein, equivalent to Q9CB94|ML2299 HYPOTHETICAL PROTEIN from Mycobacterium leprae (266 aa) FASTA scores: opt: 1358, E(): 5.2e-75, (76.4% identity in 267 aa overlap). Also similar to others (generally in C-terminal end) e.g. Q9XA45|SCH17.02c HYPOTHETICAL 26.5 KDA PROTEIN from Streptomyces coelicolor (247 aa) FASTA scores: opt: 524, E(): 1.3e-24, (42.65% identity in 251 aa overlap); Q9AB27|CC0407 MUTT/NUDIX FAMILY PROTEIN from Caulobacter crescentus (216 aa), FASTA scores: opt: 285,E(): 3.2e-10, (36.2% identity in 174 aa overlap); BAB49788|MLL2727|Q98HS8 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (204 aa), FASTA scores: opt: 278, E(): 8.1e-10, (31.45% identity in 151 aa overlap); P43337|YEAB_ECOLI|B1813 HYPOTHETICAL 21.4 KDA PROTEIN from Escherichia coli strain K12 (192 aa) FASTA scores: opt: 252, E(): 2.9e-08, (35.9% identity in 170 aa overlap); etc. Contains PS01293 Uncharacterized protein family UPF0036 signature, LLT. Q7TVZ2 No conserved hypotheticals Rv3672c NC_002945.3 Mycobrowser_v2 CDS 3681865 3683094 . - 0 Mb3371c icd1 PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) Mb3371c, icd1, len: 409 aa. Equivalent to Rv3339c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Probable icd1,isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42),highly similar to many e.g. Q9A5C8|CC2522 from Caulobacter crescentus (403 aa), FASTA scores: opt: 1972, E(): 4.6e-115, (72.45% identity in 403 aa overlap); AAF73472|ICD from Rhizobium meliloti (404 aa), FASTA scores: opt: 1968, E(): 8.1e-115, (73.2% identity in 403 aa overlap); P50215|IDH_SPHYA from Sphingomonas yanoikuyae (406 aa), FASTA scores: opt: 1964, E(): 1.4e-114, (71.45% identity in 403 aa overlap); etc. Contains PS00470 Isocitrate and isopropylmalate dehydrogenases signature. BELONGS TO THE ISOCITRATE AND ISOPROPYLMALATE DEHYDROGENASES FAMILY. X2BNC7,P65098 No NC_002945.3 Mycobrowser_v2 CDS 3752375 3753079 . + 0 Mb3418 POSSIBLE TRANSPOSASE Mb3418, -, len: 234 aa. Equivalent to Rv3386, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Possible transposase,showing very weak similarity to several IS element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap). Q7TWK8 No insertion seqs and phages Rv3386 NC_002945.3 Mycobrowser_v2 CDS 3683377 3684726 . + 0 Mb3372 metC PROBABLE O-ACETYLHOMOSERINE SULFHYDRYLASE METC (HOMOCYSTEINE SYNTHASE) (O-ACETYLHOMOSERINE (THIOL)-LYASE) (OAH SULFHYDRYLASE) (O-ACETYL-L-HOMOSERINE SULFHYDRYLASE) Mb3372, metC, len: 449 aa. Equivalent to Rv3340,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable metC,O-acetyl-L-homoserine sulfhydrylase (EC 4.2.99.10), highly similar to many e.g. Q9K9P2|BH2603 O-ACETYLHOMOSERINE SULFHYDRYLASE from Bacillus halodurans (430 aa), FASTA scores: opt: 1716, E(): 3.3e-97, (60.45% identity in 425 aa overlap); Q9HUE4|METY|PA5025 HOMOCYSTEINE SYNTHASE from Pseudomonas aeruginosa (425 aa), FASTA scores: opt: 1517,E(): 4.4e-85, (56.95% identity in 425 aa overlap); Q9WZY4|TM0882 O-ACETYLHOMOSERINE SULFHYDRYLASE from Thermotoga maritima (430 aa), FASTA scores: opt: 1488,E(): 2.6e-83, (55.75% identity in 418 aa overlap); BAB54344|MLR8465 O-ACETYLHOMOSERINE SULFHYDRYLASE from Rhizobium loti (Mesorhizobium loti) (426 aa), FASTA scores: opt: 1445, E(): 1.1e-80, (53.2% identity in 419 aa overlap); P50125|CYSD_EMENI O-ACETYLHOMOSERINE (THIOL)-LYASE from Emericella nidulans (Aspergillus nidulans) (437 aa), FASTA scores: opt: 1442, E(): 1.7e-80,(53.7% identity in 430 aa overlap); etc. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. COFACTOR: PYRIDOXAL PHOSPHATE. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. Q7TWP1 No intermediary metabolism and respiration Rv3340 NC_002945.3 Mycobrowser_v2 CDS 3684738 3685877 . + 0 Mb3373 metA PROBABLE HOMOSERINE O-ACETYLTRANSFERASE META (HOMOSERINE O-TRANS-ACETYLASE) (HOMOSERINE TRANSACETYLASE) (HTA) Mb3373, metA, len: 379 aa. Equivalent to Rv3341,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Probable metA,homoserine o-acetyltransferase (EC 2.3.1.31), equivalent to O32874|METX_MYCLE|META|ML0682|MLCB1779.11 HOMOSERINE O-ACETYLTRANSFERASE from Mycobacterium leprae (382 aa),FASTA scores: opt: 2263, E(): 9.2e-129, (85.0% identity in 380 aa overlap). Also highly similar to many e.g. O68640|METX_CORGL|META from Corynebacterium glutamicum (Brevibacterium flavum) (379 aa), FASTA scores: opt: 1135,E(): 5.9e-61, (48.5% identity in 371 aa overlap); Q9AAS1|CC0525 from Caulobacter crescentus (382 aa), FASTA scores: opt: 860, E(): 2e-44, (40.5% identity in 363 aa overlap); P94891|METX_LEPME from Leptospira meyeri (379 aa), FASTA scores: opt: 787, E(): 4.9e-40, (38.2% identity in 385 aa overlap); etc. BELONGS TO THE AB HYDROLASE FAMILY, HTA SUBFAMILY. X2BNP0,P0A5J9 No intermediary metabolism and respiration Rv3341 NC_002945.3 Mycobrowser_v2 CDS 3700427 3706717 . - 0 Mb3380c PPE55a PPE FAMILY PROTEIN [FIRST PART] Mb3380c, PPE55a, len: 2096 aa. Similar to 5' end of Rv3347c, len: 3157 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 2044 aa overlap). Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-,Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16,MTCY63_9, MTY13E10_17, MTCY180_1; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b. Q7TWN7 No NC_002945.3 Mycobrowser_v2 CDS 3685874 3686605 . + 0 Mb3374 POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb3374, -, len: 243 aa. Equivalent to Rv3342, len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 243 aa overlap). Possible methyltransferase (EC 2.1.1.-), similar to various proteins e.g. Q9I5X8|PA0558 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (255 aa), FASTA scores: opt: 496,E(): 4.4e-24, (39.85% identity in 236 aa overlap); Q9XBC9|CZA382.22c PUTATIVE RRNA METHYLASE from Amycolatopsis orientalis (259 aa), FASTA scores: opt: 473,E(): 1.2e-22, (42.45% identity in 245 aa overlap); Q9UTA8|SPAC25B8.10 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (256 aa), FASTA scores: opt: 470, E(): 1.9e-22, (35.7% identity in 238 aa overlap); and Q9UTA9|SPAC25B8.09 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (251 aa), FASTA scores: opt: 418, E(): 3.4e-19,(31.2% identity in 237 aa overlap); etc. Start uncertain. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. X2BP79,P65349 No intermediary metabolism and respiration Rv3342 NC_002945.3 Mycobrowser_v2 CDS 3690679 3694692 . - 0 Mb3376c PE_PGRS50b pe-pgrs family protein pe_pgrs49 Mb3376c, PE_PGRS50b, len: 1337 aa. Equivalent to middle part of Rv3345c (PE_PGRS50) and Rv3344c (PE_PGRS49), len: 1538 aa and 484 aa, from Mycobacterium tuberculosis strain H37Rv, (81.45% identity in 992 aa overlap and 100.000% identity in 477 aa overlap). Rv3345c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21, MTV023_15, MTCY493_4,MTV039_16, MTV008_46, MTV023_14, MTV023_19, MTV043_26,MTCY493_2, MTCY441_4; etc. Rv3344c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins. Appears to be a gene fragment,should be in-frame with following ORF, MTV016.45c,frameshift required around 49595 but could not be found on checking BAC and cosmid clones. Similar to many from M. tuberculosis strains H37Rv and CDC1551 e.g. O53557|Rv3512|MTV023.19 (1079 aa), FASTA scores: opt: 1595, E(): 1.8e-54, (52.0% identity in 544 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b. Also in Mycobacterium tuberculosis strain H37Rv, PE_PGRS49 and PE_PGRS50 exist as 2 genes. In Mycobacterium bovis, a single base deletion (c-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product. No NC_002945.3 Mycobrowser_v2 CDS 3720872 3721666 . - 0 Mb3386c CONSERVED HYPOTHETICAL PROTEIN Mb3386c, -, len: 264 aa. Equivalent to Rv3351c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Hypothetical protein,highly similar to C-terminal region (aa 292-479) of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from M. tuberculosis (479 aa), FASTA scores: opt: 699, E(): 1.7e-36, (54.75% identity in 190 aa overlap). Shows some similarity to Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 192, E(): 9.1e-05, (27.9% identity in 154 aa overlap); and P71091|YGAK HYPOTHETICAL 54.4 KDA PROTEIN from Bacillus subtilis (480 aa), FASTA scores: opt: 174,E(): 0.0014, (26.5% identity in 166 aa overlap). Note that the two upstream ORFs Rv3352c and Rv3353c also show similarity to Rv0063 (MTV030_7). Sequence was checked but no errors found. Q7TWN5 No conserved hypotheticals Rv3351c NC_002945.3 Mycobrowser_v2 CDS 3694689 3696308 . - 0 Mb3377c PE_PGRS50a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb3377c, PE_PGRS50a, len: 539 aa. Equivalent to 5' end of Rv3345c, len: 1538 aa, from Mycobacterium tuberculosis strain H37Rv, (88.25% identity in 315 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21,MTV023_15, MTCY493_4, MTV039_16, MTV008_46, MTV023_14,MTV023_19, MTV043_26, MTCY493_2, MTCY441_4; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b. Q7TWN9 No NC_002945.3 Mycobrowser_v2 CDS 3697245 3700430 . - 0 Mb3379c PPE55b PPE FAMILY PROTEIN [SECOND PART] Mb3379c, PPE55b, len: 1061 aa. Equivalent to 3' end of Rv3347c, len: 3157 aa, from Mycobacterium tuberculosis strain H37Rv, (99.812% identity in 1061 aa overlap). Member of the Mycobacterium tuberculosis PPE family, Gly-,Ala-, Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16,MTCY63_9, MTY13E10_17, MTCY180_1; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b. No NC_002945.3 Mycobrowser_v2 CDS 3719324 3720628 . - 0 Mb3385c PPE56a PPE FAMILY PROTEIN [FIRST PART] Mb3385c, PPE56a, len: 434 aa. Equivalent to 5' end of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 434 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-,Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1,MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d. Q7TWN6 No NC_002945.3 Mycobrowser_v2 CDS 3753069 3753746 . + 0 Mb3419 POSSIBLE TRANSPOSASE Mb3419, -, len: 225 aa. Equivalent to Rv3387, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Possible transposase,showing very weak similarity to other IS element proteins,and similar to various hypothetical proteins. Q7TWK7 No insertion seqs and phages Rv3387 NC_002945.3 Mycobrowser_v2 CDS 3722637 3723026 . + 0 Mb3389 CONSERVED HYPOTHETICAL PROTEIN Mb3389, -, len: 129 aa. Equivalent to Rv3354, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 129 aa overlap). Conserved hypothetical protein, equivalent (but shorter 29 aa) to Q9CCM4|ML0676 HYPOTHETICAL PROTEIN from Mycobacterium leprae (158 aa),FASTA scores: opt: 467, E(): 3.3e-21, (55.9% identity in 127 aa overlaps). Highly similar to O33192|LPRJ|Rv1690|MTCI125.12 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (127 aa), FASTA scores: opt: 329, E(): 4.7e-13, (46.95% identity in 115 aa overlap); and also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O07222|Rv1810|MTCY16F9.04c (118 aa), FASTA scores: opt: 195, E(): 4.2e-05, (37.15% identity in 113 aa overlap); MTCI125_11, MTCY16F9_4,MTV049_25. Q7TWN2 No conserved hypotheticals Rv3354 NC_002945.3 Mycobrowser_v2 CDS 3723040 3723333 . - 0 Mb3390c probable integral membrane protein Mb3390c, -, len: 97 aa. Equivalent to Rv3355c, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Hypothetical protein,equivalent to O32878|MLCB1779.16c|ML0675 HYPOTHETICAL 9.6 KDA PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 439, E(): 3.9e-23, (78.9% identity in 90 aa overlap). Identical, but with a gap, to O50377|Rv3346c|MTV004.02c HYPOTHETICAL 8.9 KDA PROTEIN from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 413, E(): 2.1e-21, (85.55% identity in 97 aa overlap). Also some similarity to other proteins e.g. Q9K3J5|SC2A6.10 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (178 aa), FASTA scores: opt: 147,E(): 0.003, (31.25% identity in 80 aa overlap). Q7TWN1 No cell wall and cell processes Rv3355c NC_002945.3 Mycobrowser_v2 CDS 3723330 3724175 . - 0 Mb3391c folD PROBABLE BIFUNCTIONAL PROTEIN FOLD: METHYLENETETRAHYDROFOLATE DEHYDROGENASE + METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE Mb3391c, folD, len: 281 aa. Equivalent to Rv3356c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 281 aa overlap). Probable folD,bifunctional enzyme include methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9), equivalent to O32879|FOLD|ML0674 METHYLENETETRAHYDROFOLATE DEHYDROGENASE (PUTATIVE METHYLENETETRAHYDROFOLATE DEHYDROGENASE/METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE) from Mycobacterium leprae (282 aa), FASTA scores: opt: 1624, E(): 1.2e-93, (86.45% identity in 281 aa overlap). Also similar to many others e.g. Q9K3J6|FOLD from Streptomyces coelicolor (284 aa), FASTA scores: opt: 1223,E(): 9.5e-69, (66.65% identity in 279 aa overlap); Q9K966|FOLD from Bacillus halodurans (279 aa), FASTA scores: opt: 886, E(): 7.7e-48, (47.15% identity in 280 aa overlap); P54382|FOLD_BACSU from Bacillus subtilis (283 aa), FASTA scores: opt: 820, E(): 9.7e-44, (45.7% identity in 280 aa overlap); P51696|FOLD_PHOPO from Photobacterium phosphoreum (285 aa), FASTA scores: opt: 778, E(): 4e-41,(44.9% identity in 283 aa overlap); P24186|FOLD_ECOLI|ADS|B0529 from Escherichia coli (287 aa), FASTA scores: opt: 741, E(): 0,44.4, (44.4% identity in 277 aa overlap); etc. Also highly similar to MLCB1779_9 from Mycobacterium leprae cosmid B1779 (282 aa) (86.5% identity in 281 aa overlap). SIMILAR TO OTHER DEHYDROGENASE/CYCLOHYDROLASE ENZYMES OR DOMAINS. X2BNF5,Q7TWN0 No NC_002945.3 Mycobrowser_v2 CDS 3724299 3724574 . + 0 Mb3392 relj antitoxin relj Mb3392, -, len: 91 aa. Equivalent to Rv3357, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9Z4V7|YU1E_STRCO (alias CAC37261|SCBAC17D6.02) ORFU1E (BELONGS TO THE PHD/YEFM FAMILY) from Streptomyces coelicolor (87 aa), FASTA scores: opt: 344, E(): 1.9e-17,(62.05% identity in 87 aa overlap); P46147|YEFM_ECOLI|B2017 from Escherichia coli strain K12 (83 aa), FASTA scores: opt: 215, E(): 1.6e-08, (50.0% identity in 72 aa overlap); BAB58570|SAV2408 from Staphylococcus aureus subsp. aureus Mu50 (83 aa), FASTA scores: opt: 161, E(): 8.8e-05, (39.95% identity in 77 aa overlap); Q9Z5W8 PUTATIVE PHD PROTEIN from Francisella novicid (85 aa), FASTA scores: opt: 143, E(): 0.0016,(28.9% identity in 83 aa overlap); etc. Also similar to Rv1247c|MTV006.19c (89 aa) (36.9% identity in 84 aa overlap). SEEMS TO BELONG TO THE PHD/YEFM FAMILY. X2BN90 No virulence, detoxification, adaptation Rv3357 NC_002945.3 Mycobrowser_v2 CDS 3724870 3726060 . + 0 Mb3394 POSSIBLE OXIDOREDUCTASE Mb3394, -, len: 396 aa. Equivalent to Rv3359, len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to N-terminal part of various proteins (hypothetical unknowns or oxidoreductases) e.g. Q9ZB94 HYPOTHETICAL 69.3 KDA PROTEIN from Rhodococcus erythropolis (649 aa), FASTA scores: opt: 509, E(): 3e-24, (30.0% identity in 380 aa overlap); O29991|AF0248 NADH-DEPENDENT FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (378 aa), FASTA scores: opt: 478,E(): 1.6e-22, (32.45% identity in 379 aa overlap); Q9HUH9|PA4986 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (648 aa), FASTA scores: opt: 412, E(): 3.3e-18,(30.45% identity in 384 aa overlap); Q9KCT8|BH1481 NADH OXIDASE from Bacillus halodurans (338 aa), FASTA scores: opt: 404, E(): 6.1e-18, (30.2% identity in 275 aa overlap); etc. Some weak similarity to Mycobacterium leprae MLCB1779_10. Q7TWM9 No intermediary metabolism and respiration Rv3359 NC_002945.3 Mycobrowser_v2 CDS 3726177 3726545 . + 0 Mb3395 CONSERVED HYPOTHETICAL PROTEIN Mb3395, -, len: 122 aa. Equivalent to Rv3360, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical protein,highly similar to the N-terminus of O65934|Rv1747|MTCY28.10|MTCY04C12.31 probable ABC-transporter ATP-binding protein from Mycobacterium tuberculosis (865 aa), FASTA scores: opt: 480, E(): 4.7e-25, (61.0% identity in 118 aa overlap); and some similarity with the N-terminus of P96214|Rv3863|MTCY01A6.05c HYPOTHETICAL 41.1 KDA PROTEIN from Mycobacterium tuberculosis (392 aa), FASTA scores: opt: 138, E(): 0.033, (31.95% identity in 97 aa overlap). Some weak similarity with the N-terminus of other hypothetical proteins e.g. P73823|CYAA|SLR1991 ADENYLATE CYCLASE from Synechocystis sp. strain PCC 6803 (337 aa),FASTA scores: opt: 127, E(): 0.16, (28.55% identity in 112 aa overlap). Q7TWM8 No conserved hypotheticals Rv3360 NC_002945.3 Mycobrowser_v2 CDS 3726542 3727093 . - 0 Mb3396c conserved protein Mb3396c, -, len: 183 aa. Equivalent to Rv3361c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, with some similarity to various proteins e.g. P74221|YB52_SYNY3|SLR1152 HYPOTHETICAL 36.2 KDA PROTEIN SLR (CONTAINS 5 PENTAPEPTIDE REPEAT DOMAINS) from Synechocystis sp. strain PCC 6803 (331 aa), FASTA scores: opt: 252, E(): 3.9e-10, (30.55% identity in 167 aa overlap); Q9SE95 FH PROTEIN INTERACTING PROTEIN FIP2 from Arabidopsis thaliana (Mouse-ear cress) (298 aa), FASTA scores: opt: 207, E(): 4.4e-07, (30.35% identity in 168 aa overlap); Q9A735|CC1891 PENTAPEPTIDE REPEAT FAMILY PROTEIN from Caulobacter crescentus (250 aa), FASTA scores: opt: 181, E(): 2.3e-05, (24.05% identity in 187 aa overlap); etc. Q7TWM7 No conserved hypotheticals Rv3361c NC_002945.3 Mycobrowser_v2 CDS 3728397 3731027 . - 0 Mb3400c conserved protein Mb3400c, -, len: 876 aa. Equivalent to Rv3365c,len: 876 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 876 aa overlap). Conserved hypothetical protein, similar to various proteins from Streptomyces coelicolor e.g. O86525|SC1C2.25c HYPOTHETICAL 139.7 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1329 aa), FASTA scores: opt: 879, E(): 5.4e-32, (29.9% identity in 924 aa overlap) (similarity in N-terminal part for this one); O86522|SC1C2.21c HYPOTHETICAL 119.9 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1111 aa), FASTA scores: opt: 855, E(): 5.6e-31,(28.9% identity in 892 aa overlap) (similarity in N-terminal part for this one); Q9KZI5|SCG8A.14c PUTATIVE MEMBRANE PROTEIN (862 aa), FASTA scores: opt: 791, E(): 3.3e-28, (30.8% identity in 828 aa overlap); Q9KZN0|SC1A8A.22c (943 aa), FASTA scores: opt: 660, E(): 2.5e-22, (27.65% identity in 893 aa overlap); etc. Similar in part to two consecutive Mycobacterium leprae hypothetical ORFs, probably representing a pseudogene: O07701|MLCL383.27 (118 aa), FASTA scores: opt: 430, E(): 1e-12, (58.25% identity in 115 aa overlap); and O07700|MLCL383.26 (111 aa), FASTA scores: opt: 271, E(): 1.3e-05, (50.4% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q7TVB4 No conserved hypotheticals Rv3365c NC_002945.3 Mycobrowser_v2 CDS 3731263 3731727 . + 0 Mb3401 spoU PROBABLE tRNA/rRNA METHYLASE SPOU (tRNA/rRNA METHYLTRANSFERASE) Mb3401, spoU, len: 154 aa. Equivalent to Rv3366,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Probable spoU,tRNA/rRNA methylase (EC 2.1.1.-), equivalent to Q9CCU7|ML0419 PUTATIVE tRNA/rRNA METHYLTRANSFERASE from Mycobacterium leprae (158 aa), FASTA scores: opt: 861,E(): 1.2e-50, (83.75% identity in 154 aa overlap); and O07698|MLCL383.24c rRNA METHYLASE from Mycobacterium leprae (169 aa), FASTA scores: opt: 861, E(): 1.3e-50,(83.75% identity in 154 aa overlap). Also highly similar to many members of the spoU family of rRNA methylases e.g. Q9K199|NMB0268 RNA METHYLTRANSFERASE (TRMH FAMILY) from Neisseria meningitidis (serogroup B) (154 aa), FASTA scores: opt: 534, E(): 7.6e-29, (50.0% identity in 154 aa overlap); and Q9JSM8|NMA2218 from Neisseria meningitidis (serogroup A) (154 aa), FASTA scores: opt: 526, E(): 2.6e-28, (49.35% identity in 154 aa overlap); Q9HU57|PA5127 from Pseudomonas aeruginosa (153 aa), FASTA scores: opt: 531, E(): 1.2e-28, (52.95% identity in 151 aa overlap); P33899|YIBK_ECOLI|B3606 from Escherichia coli strain K12 (157 aa), FASTA scores: opt: 511, E(): 2.6e-27,(49.35% identity in 154 aa overlap); etc. BELONGS TO THE RNA METHYLTRANSFERASE TRMH FAMILY. Q7TWM3 No information pathways Rv3366 NC_002945.3 Mycobrowser_v2 CDS 3779176 3779586 . + 0 Mb3442 vapc47 possible toxin vapc47. contains pin domain. Mb3442, -, len: 136 aa. Equivalent to Rv3408, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 136 aa overlap). Hypothetical protein,similar to other hypothetical proteins from M. tuberculosis strains H37Rv and CDC1551 e.g. O50411|Rv3384c|MTV004.42c (130 aa), FASTA scores: opt: 243, E(): 1.7e-09, (35.1% identity in 131 aa overlap); P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: 191, E(): 5e-06, (35.5% identity in 138 aa overlap), etc. Q7TWJ5 No virulence, detoxification, adaptation Rv3408 NC_002945.3 Mycobrowser_v2 CDS 3732094 3733974 . + 0 Mb3402 PE_PGRS51 pe-pgrs family protein pe_pgrs51 Mb3402, PE_PGRS51, len: 626 aa. Similar to Rv3367,len: 588 aa, from Mycobacterium tuberculosis strain H37Rv,(93.75% identity in 626 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50415|Rv3388|MTV004.46 (731 aa), FASTA scores: opt: 1999,E(): 7.2e-72, (55.0% identity in 620 aa overlap); and MTV004_44, MTV043_65, MTV006_15, MTCY63_2, MTCY21B4_13,MTV023_21, MTV008_43, MTCY24A1_4, MTV023_15; etc. Equivalent to AAK47814 from M. tuberculosis strain CDC1551 (628 aa) but shorter 37 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-ggcagcggt) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa). Q7TWM2 No NC_002945.3 Mycobrowser_v2 CDS 3833769 3834779 . - 0 Mb3498c mhpE PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE MHPE (HOA) Mb3498c, mhpE, len: 336 aa. Equivalent to Rv3469c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable mhpE,4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), similar to others (principally from Pseudomonas species) e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338 aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65% identity in 332 aa overlap); Q9X9Q0|NIKB NIKB PROTEIN (see first citation below) from Streptomyces tendae (357 aa),FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in 339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp. strain KKS102 (352 aa), FASTA scores: opt: 549, E(): 9.9e-27, (31.2% identity in 314 aa overlap); Q51983|CMTG_PSEPU from Pseudomonas putida (350 aa), FASTA scores: opt: 543, E(): 2.3e-26, (30.7% identity in 319 aa overlap); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 517, E(): 9.1e-25, (31.75% identity in 312 aa overlap); etc. Also similar to P71867|MTCY03C7.22|Rv3534c HYPOTHETICAL 36.4 KDA PROTEIN from Mycobacterium tuberculosis (346 aa),FASTA scores: E(): 7.5e-24, (31.9% identity in 310 aa overlap). Q7TWG2 No NC_002945.3 Mycobrowser_v2 CDS 3733975 3734619 . - 0 Mb3403c POSSIBLE OXIDOREDUCTASE Mb3403c, -, len: 214 aa. Equivalent to Rv3368c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to O07697|MLCL383.23|ML0418 HYPOTHETICAL 23.6 KDA PROTEIN (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (210 aa), FASTA scores: opt: 1215, E(): 1.5e-74, (81.4% identity in 210 aa overlap). Also similar to O30106|AF0131 PUTATIVE NAD(P)H-FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (194 aa), FASTA scores: opt: 139, E(): 0.028,(29.0% identity in 207 aa overlap); Q60049|NOX_THETH NADH DEHYDROGENASE from Thermus aquaticus (subsp. thermophilus) (205 aa), FASTA scores: opt: 169, E(): 0.00028, (28.3% identity in 212 aa overlap); and shows some similarity to other hypothetical proteins (unknowns or oxidoreductases). Q7TWM1 No intermediary metabolism and respiration Rv3368c NC_002945.3 Mycobrowser_v2 CDS 3734618 3735052 . + 0 Mb3404 conserved protein Mb3404, -, len: 144 aa. Equivalent to Rv3369, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Conserved hypothetical protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c HYPOTHETICAL 14.7 KDA PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: opt: 174,E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa), FASTA scores: opt: 125, E(): 0.13,(31.05% identity in 116 aa overlap). Q7TWM0 No conserved hypotheticals Rv3369 NC_002945.3 Mycobrowser_v2 CDS 3735141 3738380 . - 0 Mb3405c dnaE2 PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE2 (DNA NUCLEOTIDYLTRANSFERASE) Mb3405c, dnaE2, len: 1079 aa. Equivalent to Rv3370c, len: 1079 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1079 aa overlap). Probable dnaE2, DNA polymerase III, alpha chain (EC 2.7.7.7), similar to many e.g. BAB51086|MLR4428 from Rhizobium loti (Mesorhizobium loti) (1118 aa), FASTA scores: opt: 1103, E(): 8.9e-59, (37.65% identity in 1075 aa overlap); Q9S291|SCI11.28c from Streptomyces coelicolor (1185 aa), FASTA scores: opt: 937, E(): 1e-48, (33.4% identity in 1090 aa overlap); O67125|DP3A_AQUAE|DNAE|AQ_1008 from Aquifex aeolicus (1161 aa), FASTA scores: opt: 895, E(): 3.4e-46, (29.9% identity in 1071 aa overlap); O51526|DP3A_BORBU from Borrelia burgdorferi (Lyme disease spirochete) (1147 aa), FASTA scores: opt: 835, E(): 1.4e-42, (30.05% identity in 888 aa overlap); etc. Equivalent to AAK47817 from Mycobacterium tuberculosis strain CDC1551 (1098 aa) but shorter 19 aa. Also similar to Mycobacterium tuberculosis DP3A_MYCTU|MTCY48.18c (29.6% identity in 1110 aa overlap). BELONGS TO DNA POLYMERASE TYPE-C FAMILY, DNAE SUBFAMILY. X2BN20,Q7TWL9 No information pathways Rv3370c NC_002945.3 Mycobrowser_v2 CDS 3738572 3739912 . + 0 Mb3406 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb3406, -, len: 446 aa. Equivalent to Rv3371, len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 446 aa overlap). Hypothetical protein,similar to many Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. O07035|YV30_MYCTU|Rv3130c|MTCY03A2.28|MTCY164.41c (463 aa), FASTA scores: opt: 556, E(): 7.7e-28, (44.95% identity in 447 aa overlap); MTY20B11_9, MTCY28_26,MTV013_8, MTCY21B4_43, MTCY493_29; etc. Also similar to O07692|MLCL383_9|MLCL383.18c HYPOTHETICAL 14.1 KDA PROTEIN from Mycobacterium leprae (129 aa), FASTA scores: opt: 293, E(): 1.3e-11, (47.85% identity in 117 aa overlap). Q7TWL8 No lipid metabolism Rv3371 NC_002945.3 Mycobrowser_v2 CDS 3856570 3857298 . - 0 Mb3523c CONSERVED HYPOTHETICAL MCE ASSOCIATED ALANINE AND VALINE RICH PROTEIN Mb3523c, -, len: 242 aa. Equivalent to Rv3493c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical Mce-associated ala-, val-rich protein,showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 HYPOTHETICAL 25.9 KDA PROTEIN (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). Q7TWD8 No conserved hypotheticals Rv3493c NC_002945.3 Mycobrowser_v2 CDS 3739954 3741129 . + 0 Mb3407 otsB2 trehalose 6-phosphate phosphatase otsb2 (trehalose-phosphatase) (tpp) Mb3407, otsB2, len: 391 aa. Equivalent to Rv3372,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 391 aa overlap). Possible otsB2,trehalose-6-phosphate phosphatase (EC 3.1.3.12),equivalent to Q49734|OTSB2|OTSP|B1620_F1_1|MLCL383.17c PUTATIVE TREHALOSE-PHOSPHATASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 1675, E(): 2.4e-91, (67.05% identity in 425 aa overlap). Also weakly similar to several trehalose phosphatases e.g. Q9C8B3|F10O5.8 from Arabidopsis thaliana (Mouse-ear cress) (366 aa), FASTA scores: opt: 432, E(): 3.1e-18, (36.65% identity in 281 aa overlap); O27788|MTH1760 from Methanobacterium thermoautotrophicum (264 aa), FASTA scores: opt: 347, E(): 2.5e-13, (30.75% identity in 221 aa overlap); Q9FWQ2 from Oryza sativa (Rice) (382 aa), FASTA scores: opt: 338, E(): 1.1e-12, (32.5% identity in 320 aa overlap); etc. Also similar to part of Mycobacterium tuberculosis Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),FASTA scores: opt: 1192, E(): 1.6e-62, (56.65% identity in 339 aa overlap). X2BNA0,Q7TWL7 No NC_002945.3 Mycobrowser_v2 CDS 3742261 3743688 . + 0 Mb3409 amiD PROBABLE AMIDASE AMID (ACYLAMIDASE) (ACYLASE) Mb3409, amiD, len: 475 aa. Equivalent to Rv3375,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 475 aa overlap). Probable amiD,amidase (EC 3.5.1.4), similar to various amidases e.g. Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from Rhodococcus sp. (462 aa), FASTA scores: opt: 1036, E(): 1.6e-54, (38.6% identity in 464 aa overlap); Q9ZHK8|PZAA NICOTINAMIDASE/PYRAZINAMIDASE from Mycobacterium smegmatis (468 aa), FASTA scores: opt: 930, E(): 3.4e-48, (36.3% identity in 463 aa overlap); Q9A551|CC2613 PYRAZINAMIDASE/NICOTINAMIDASE from Caulobacter crescentus (464 aa), FASTA scores: opt: 841, E(): 7.1e-43, (39.45% identity in 469 aa overlap); O69768|AMID_PSEPU AMIDASE from Pseudomonas putida (466 aa), FASTA scores: opt: 800,E(): 2e-40, (33.6% identity in 467 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from Archaeoglobus fulgidu (453 aa), FASTA scores: opt: 669,E(): 1.3e-32, (30.4% identity in 467 aa overlap); etc. Also some similarity to AMIB2|Rv1263|MT1301|MTCY50.19c putative amidase from Mycobacterium tuberculosis (462 aa),(31.5% identity in 466 aa overlap). SEEMS BELONG TO THE AMIDASE FAMILY. X2BPC8,P63497 No intermediary metabolism and respiration Rv3375 NC_002945.3 Mycobrowser_v2 CDS 3743796 3744449 . + 0 Mb3410 CONSERVED HYPOTHETICAL PROTEIN Mb3410, -, len: 217 aa. Equivalent to Rv3376, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Hypothetical protein,similar to various bacterial proteins (notably hydrolases) e.g. Q9RUP0|DR1344 HYDROLASE from Deinococcus radiodurans (222 aa), FASTA scores: opt: 348, E(): 1.8e-15, (36.75% identity in 215 aa overlap); Q9RXA1|DR0414 HYDROLASE (CBBY/CBBZ/GPH/YIEH FAMILY) from Deinococcus radiodurans (155 aa), FASTA scores: opt: 233, E(): 3.5e-08, (36.4% identity in 151 aa overlap); Q9X0Q9|TM1177 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (225 aa),FASTA scores: opt: 231, E(): 6.6e-08, (27.6% identity in 221 aa overlap); Q9ABI3|CC0244 HYDROLASE, HALOACID DEHALOGENASE-LIKE from Caulobacter crescentus (213 aa),FASTA scores: opt: 213, E(): 9.1e-07, (28.95% identity in 221 aa overlap); BAB38231|ECS4808 PUTATIVE PHOSPHATASE from Escherichia coli strain O157:H7 (206 aa), FASTA scores: opt: 210, E(): 1.4e-06, (26.95% identity in 193 aa overlap); etc. Q7TWL5 No conserved hypotheticals Rv3376 NC_002945.3 Mycobrowser_v2 CDS 3744541 3745992 . - 0 Mb3411c halimadienyl diphosphate synthase Mb3411c, -, len: 483 aa. Similar to the 5' end of Rv3377c, len: 501 aa, from Mycobacterium tuberculosis strain H37Rv, (89.9% identity in 464 aa overlap). Possible cyclase; similarity with various proteins, notably cyclases involved in steroid biosynthesis in plants and bacteria e.g. BAB52679|MLR6369 from Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA scores: opt: 533,E(): 5.6e-27, (30.45% identity in 522 aa overlap); Q9ZTN8 COPALYL DIPHOSPHATE SYNTHASE 1 from Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA scores: opt: 484, E(): 1.2e-23, (28.35% identity in 388 aa overlap); Q38710|AC22 ABIETADIENE CYCLASE from Abies grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17, (25.55% identity in 462 aa overlap); Q41771|AN1 KAURENE SYNTHASE A from Zea mays (Maize) (823 aa), FASTA scores: opt: 377,E(): 1.1e-16, (29.75% identity in 390 aa overlap); Q9AJE4 DITERPENE CYCLASE-1 from Kitasatospora griseola (Streptomyces griseolosporeus) (499 aa), FASTA scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa overlap); Q9SAU6 E-ALPHA-BISABOLENE SYNTHASE (FRAGMENT) from Abies grandis (782 aa), FASTA scores: opt: 317, E(): 7.8e-13, (25.25% identity in 479 aa overlap); etc. Note that this and the upstream ORF MTV004.36c have a significantly lower GC bias than the rest of the genome. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (caat-aac) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7TWL4 No NC_002945.3 Mycobrowser_v2 CDS 3745997 3746887 . - 0 Mb3412c diterpene synthase Mb3412c, -, len: 296 aa. Equivalent to Rv3378c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Hypothetical unknown protein. Note that this ORF and the downstream ORF MTV004.35c have a significantly lower GC bias than the rest of the genome. Q7TWL3 No intermediary metabolism and respiration Rv3378c NC_002945.3 Mycobrowser_v2 CDS 3746896 3748506 . - 0 Mb3413c dxs2 PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS2 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) Mb3413c, dxs2, len: 536 aa. Equivalent to Rv3379c,len: 536 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 536 aa overlap). Probable dxs2,1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-),similar to many e.g. Q9F1V2|DXS from Kitasatospora griseola (Streptomyces griseolosporeus) (649 aa), FASTA scores: opt: 1274, E(): 5.4e-71, (50.9% identity in 570 aa overlap); Q9X7W3|DXS_STRCO|SC6A5.17 from Streptomyces coelicolor (656 aa), FASTA scores: opt: 1248, E(): 2.2e-69, (50.55% identity in 568 aa overlap); Q9RBN6|DXS_STRC1 from Streptomyces sp. strain CL190 (631 aa), FASTA scores: opt: 1237, E(): 1e-68, (49.1% identity in 570 aa overlap); Q50000|DXS_MYCLE|TKTB|ML1038 from M. leprae (643 aa), FASTA scores: opt: 1215, E(): 2.4e-67,(46.75% identity in 571 aa overlap); Q9R6S7|DXS_SYNLE from Synechococcus leopoliensis (636 aa), FASTA scores: opt: 849, E(): 8.9e-45, (38.55% identity in 550 aa overlap); etc. Also similar to O07184|DXS_MYCTU|Rv2682c|MT2756|MTCY05A6.03c from M. tuberculosis (638 aa), FASTA scores: opt: 1226, E(): 4.9e-68, (48.9% identity in 558 aa overlap). BELONGS TO THE TRANSKETOLASE FAMILY, DXS SUBFAMILY. COFACTOR: THIAMINE PYROPHOSPHATE (BY SIMILARITY). Note that the N-terminus of this putative protein appears to have been interrupted by the adjacent IS6110 element. Q7TWL2 No NC_002945.3 Mycobrowser_v2 CDS 3748731 3749720 . - 0 Mb3414c lytB1 PROBABLE LYTB-RELATED PROTEIN LYTB1 Mb3414c, lytB1, len: 329 aa. Equivalent to Rv3382c,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 329 aa overlap). Probable lytB1,lytB-related protein, highly similar to many e.g. Q9HVM7|LYTB_PSEAE|PA4557 from Pseudomonas aeruginosa (314 aa), FASTA scores: opt: 1048, E(): 2e-55, (53.2% identity in 314 aa overlap); Q9JR39|LYTB|NMA0624|NMB1831 from Neisseria meningitidis (serogroup A and B) (322 aa), FASTA scores: opt: 1041, E(): 5.4e-55, (52.25% identity in 312 aa overlap); P22565|LYTB_ECOLI|B0029 from Escherichia coli strain K12 (316 aa), FASTA scores: opt: 1013, E(): 2.5e-53, (51.45% identity in 311 aa overlap) (for more information about lytB protein, see citation below); Q9X781|LYTB_MYCLE|LYTB2|ML1938|MLCB1222.06c from Mycobacterium leprae (332 aa), FASTA scores: opt: 979,E(): 2.8e-51, (51.3% identity in 312 aa overlap); etc. Also similar to Q9PAS9|XF2416 DRUG TOLERANCE PROTEIN from Xylella fastidiosa (316 aa), FASTA scores: opt: 1043, E(): 4.1e-55, (53.65% identity in 315 aa overlap). And similar to O53458|Rv1110|LYTB2|MTV017.63 from Mycobacterium tuberculosis (335 aa), FASTA scores: opt: 975, E(): 4.9e-51, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY. X2BPD5,P0A5I3 No NC_002945.3 Mycobrowser_v2 CDS 3749720 3750772 . - 0 Mb3415c idsB POSSIBLE POLYPRENYL SYNTHETASE IDSB (POLYPRENYL TRANSFERASE) (POLYPRENYL DIPHOSPHATE SYNTHASE) Mb3415c, idsB, len: 350 aa. Equivalent to Rv3383c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 350 aa overlap). Possible idsB,polyprenyl transferase (polyprenyl diphosphate synthase) (EC 2.5.1.-), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR GERANYL TRANSFERASE from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908, E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS GERANYL GERANYL DIPHOSPHATE SYNTHASE from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 PUTATIVE POLYPRENYL SYNTHETASE from Streptomyces coelicolor (378 aa), FASTA scores: opt: 779, E(): 5.3e-42, (44.45% identity in 324 aa overlap); Q9S5E9 FARNESYL, GERANYLGERANYL,GERANYLFARNESYL, HEXAPRENYL, HEPTAPRENYL DIPHOSPHATE SYNTHASE (SELF-HEPPS) from Synechococcus elongatus (324 aa), FASTA scores: opt: 563, E(): 2.3e-28, (39.85% identity in 241 aa overlap) (see citation below); O26156|IDSA_METTH|MTH50 BIFUNCTIONAL SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE [INCLUDES: FARNESYL PYROPHOSPHATE SYNTHETASE (EC 2.5.1.1) (FPP SYNTHETASE) (DIMETHYLALLYLTRANSFERASE) AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10)] from Methanobacterium thermoautotrophicum (325 aa), FASTA scores: opt: 540, E(): 6.5e-27, (35.75% identity in 319 aa overlap); P95999|GGPP_SULSO|GDS|GDS-1|SSO0061|C05010|C05_049 GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (GGPP SYNTHETASE) (GGPS) [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1)AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10) AND FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Sulfolobus solfataricus (332 aa), FASTA scores: opt: 511, E(): 4.5e-25 (36.9% identity in 244 aa overlap); etc. Also similar to Q50727|GGPP_MYCTU|Rv3398c|MT3506|MTCY78.30 PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1); GERANYLTRANSTRANSFERASE (EC 2.5.1.10); FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 687, E(): 3.4e-36, (39.1% identity in 325 aa overlap). Contains PS00723 Polyprenyl synthetases signature 1. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY. Q7TWL1 No NC_002945.3 Mycobrowser_v2 CDS 3751526 3751918 . - 0 Mb3416c vapc46 possible toxin vapc46. contains pin domain. Mb3416c, -, len: 130 aa. Equivalent to Rv3384c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Hypothetical protein,similar to Mycobacterium tuberculosis hypothetical proteins P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: 266, E(): 1.6e-10, (43.1% identity in 130 aa overlap); and Q50717|YY08_MYCTU|Rv3408|MTCY78.20c (136 aa), FASTA scores: opt: 243, E(): 4.8e-09, (35.1% identity in 131 aa overlap). Q7TWL0 No virulence, detoxification, adaptation Rv3384c NC_002945.3 Mycobrowser_v2 CDS 3751918 3752226 . - 0 Mb3417c vapb46 possible antitoxin vapb46 Mb3417c, -, len: 102 aa. Equivalent to Rv3385c,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Hypothetical protein,similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 (99 aa), FASTA scores: opt: 155, E(): 0.001, (41.05% identity in 78 aa overlap); O07782|Rv0596c|MTCY19H5.26 (85 aa), FASTA scores: opt: 136, E(): 0.016, (39.45% identity in 71 aa overlap); P96916|Rv0626|MTCY20H10.07 (86 aa),FASTA scores: opt: 130, E(): 0.04, (51.2% identity in 41 aa overlap); etc. Also similar to PREVENT HOST DEATH (PHD) PROTEINS e.g. CAA66834|PHD from Escherichia coli (73 aa),FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap); and Q06253|PHD_BPP1 from Bacteriophage P1 (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap). Q7TWK9 No virulence, detoxification, adaptation Rv3385c NC_002945.3 Mycobrowser_v2 CDS 3753936 3756185 . + 0 Mb3420 PE_PGRS52 pe-pgrs family protein pe_pgrs52 Mb3420, PE_PGRS52, len: 749 aa. Similar to Rv3388,len: 731 aa, from Mycobacterium tuberculosis strain H37Rv,(94.8% identity in 734 aa overlap). Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many PE-family proteins from M. tuberculosis strains H37Rv and CDC1551 e.g. O53553|YZ08_MYCTU|RV3508|MTV023.15 (1901 aa), FASTA scores: opt: 2380, E(): 3.6e-87, (53.8% identity in 773 aa overlap); and MTV023_21, MTV023_18, MTV023_14, MTV039_16,MTCY441_4. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (cggcggcgc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (749 aa versus 731 aa). Q7TWK6 No NC_002945.3 Mycobrowser_v2 CDS 3774890 3776491 . - 0 Mb3437c HYPOTHETICAL PROTEIN Mb3437c, -, len: 533 aa. Equivalent to Rv3403c,len: 533 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 533 aa overlap). Hypothetical unknown protein, but some weak similarity to Q9KJP2 HYPOTHETICAL 54.9 KDA PROTEIN from Myxococcus xanthus (504 aa), FASTA scores: opt: 157, E(): 0.011, (24.1% identity in 548 aa overlap). X2BNL8,P65072 No conserved hypotheticals Rv3403c NC_002945.3 Mycobrowser_v2 CDS 3756256 3757128 . - 0 Mb3421c htdy probable 3-hydroxyacyl-thioester dehydratase htdy Mb3421c, -, len: 290 aa. Equivalent to Rv3389c,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 290 aa overlap). Possible dehydrogenase (EC 1.-.-.-), similar to parts of several bacterial dehydrogenases and eukaryotic short-chain dehydrogenases involved in steroid biosynthesis e.g. Q9UVH9|FOX2 FOX2 PROTEIN (a multifunctional protein of the peroxisomal beta-oxidation) (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Glomus mosseae (1015 aa), FASTA scores: opt: 649, E(): 7.5e-33,(40.9% identity in 269 aa overlap); Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 602, E(): 2.7e-30, (40.35% identity in 305 aa overlap); AAH03098 HYDROXYSTEROID (17-BETA) DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); P51659|DHB4_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); Q19058|E04F6.3 HYDRATASE-DEHYDROGENASE-EPIMERASE from Caenorhabditis elegans (298 aa), FASTA scores: opt: 573, E(): 1.6e-28,(41.0% identity in 266 aa overlap); O42484 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE IV from Gallus gallus (Chicken) (735 aa), FASTA scores: opt: 573, E(): 3.2e-28, (39.8% identity in 279 aa overlap); etc. And also similar in part to Q9LBK1|PHAJ2|PA1018 (R)-SPECIFIC ENOYL-COA HYDRATASE from Pseudomonas aeruginosa (288 aa),FASTA scores: opt: 601, E(): 2.7e-30, (40.5% identity in 294 aa overlap). And similar to P71863|UFAA2|Rv3538|MTCY03C7.18c HYPOTHETICAL 30.2 KDA PROTEIN from Mycobacterium tuberculosis (286 aa), FASTA scores: opt: 609, E(): 8.7e-31, (39.65% identity in 285 aa overlap). HAS SOME SIMILARITY TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TWK5 No intermediary metabolism and respiration Rv3389c NC_002945.3 Mycobrowser_v2 CDS 3757202 3757912 . + 0 Mb3422 lpqD PROBABLE CONSERVED LIPOPROTEIN LPQD Mb3422, lpqD, len: 236 aa. Equivalent to Rv3390,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Probable lpqD, a conserved lipoprotein with some similarity to various bacterial proteins e.g. Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa), FASTA scores: opt: 416, E(): 2.5e-18, (33.0% identity in 197 aa overlap); Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 314, E(): 3.7e-12, (28.55% identity in 203 aa overlap); P73454|SLR1748 HYPOTHETICAL 24.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (214 aa), FASTA scores: opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. O53817|Rv0754|MTV041.28 PGRS-FAMILY PROTEIN (584 aa), FASTA scores: opt: 219, E(): 5.1e-06, (39.8% identity in 226 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TWK4 No cell wall and cell processes Rv3390 NC_002945.3 Mycobrowser_v2 CDS 3757958 3759910 . + 0 Mb3423 acrA1 POSSIBLE MULTI-FUNCTIONAL ENZYME WITH ACYL-CoA-REDUCTASE ACTIVITY ACRA1 Mb3423, acrA1, len: 650 aa. Equivalent to Rv3391,len: 650 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 650 aa overlap). Possible acrA1, multi functional protein with fatty acyl-CoA reductase activity in C-terminal part (EC 1.2.1.-). Indeed C-terminal part highly similar to P94129|ACR1 FATTY ACYL-COA REDUCTASE from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 767, E(): 1.4e-36, (45.4% identity in 260 aa overlap); and similar to other oxidoreductases dehydrogenases/reductases e.g. Q9Y3A1 CGI-93 PROTEIN (SIMILARITY WITH SDR FAMILY) from Homo sapiens (Human) (291 aa), FASTA scores: opt: 363, E(): 1.5e-13, (38.65% identity in 194 aa overlap); Q9L146|SC6D11.09 PUTATIVE OXIDOREDUCTASE (SIMILARITY WITH SDR FAMILY) from Streptomyces coelicolor (343 aa), FASTA scores: opt: 346,E(): 1.6e-12, (30.4% identity in 283 aa overlap); Q9HSR4|YUSZ1|VNG0115G OXIDOREDUCTASE from Halobacterium sp. strain NRC-1 (260 aa), FASTA scores: opt: 338, E(): 3.7e-12, (33.85% identity in 248 aa overlap); etc. C-terminus also similar to Mycobacterium tuberculosis proteins Q10783|YF43_MYCTU|Rv1543|MTCY48.22c PUTATIVE OXIDOREDUCTASE (341 aa), FASTA scores: opt: 787, E(): 1.2e-37, (39.8% identity in 319 aa overlap); O06413|Rv0547c|MTCY25D10.26c HYPOTHETICAL 31.8 KDA PROTEIN (294 aa), FASTA scores: opt: 565, E(): 4.7e-25, (36.8% identity in 242 aa overlap); O53398|Rv1050|MTV017.03 OXIDOREDUCTASE (SDR FAMILY) (301 aa), FASTA scores: opt: 436, E(): 1.1e-17, (32.2% identity in 292 aa overlap). N-terminus (aa 1-320) is similar to P37693|HETM_ANASP polyketide synthase hetM from Anabaena sp. (506 aa), FASTA scores: opt: 188, E(): 1.3e-07, (27.7% identity in 361 aa overlap); so certainly a multi-domain enzyme. SEEMS TO BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Note that this ORF corresponds to the gene ORF2|Q11197 (in citation mentioned below), but longer 266 aa, due to use of a more upstream start site. Q7TWK3 No NC_002945.3 Mycobrowser_v2 CDS 3801641 3802495 . - 0 Mb3465c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3465c, -, len: 284 aa. Equivalent to Rv3435c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Probable conserved transmembrane protein, showing some similarity with P95061|Rv0713|MTCY210.32 HYPOTHETICAL 33.9 KDA PROTEIN from Mycobacterium tuberculosis (313 aa), FASTA scores: opt: 557, E(): 1.3e-26, (35.8% identity in 282 aa overlap); and O32991|MLCB2492.12 from Mycobacterium leprae (95 aa), FASTA scores: opt: 150, E(): 0.022, (35.3% identity in 85 aa overlap). Equivalent to AAK47881 from Mycobacterium tuberculosis strain CDC1551 (312 aa) but shorter 28 aa. Q7TWI4 No cell wall and cell processes Rv3435c NC_002945.3 Mycobrowser_v2 CDS 3759911 3760774 . - 0 Mb3424c cmaA1 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 CMAA1 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) Mb3424c, cmaA1, len: 287 aa. Equivalent to Rv3392c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). cmaA1, cyclopropane mycolic acid synthase 1 (EC 2.1.1.79), characterized in 1995 as CFA1_MYCTU|Q11195|CMAA1|CMA1 cyclopropane-fatty-acyl-phospholipid synthase 1 (see citations below). Highly similar to Mycobacterium tuberculosis proteins MTCY20H10.23c (58.7% identity in 286 aa overlap); MTCY20H10.24c (68.6% identity); MTCY20H10.25c (73.5% identity); MTCY20H10.26c (57.0% identity); and MTCY20G9.30c (55.7% identity). Also highly similar to Q9CBK3|MMAA4|ML1903 METHYL MYCOLIC ACID SYNTHASES from Mycobacterium leprae (298 aa), FASTA scores: opt: 1098,E(): 1e-63, (57.0% identity in 286 aa overlap). Equivalent to AAK44898|MT0672 from Mycobacterium tuberculosis strain CDC1551 (317 aa) but shorter 30 aa and with some differences in residues between the proteins. Q7TWK2 No NC_002945.3 Mycobrowser_v2 CDS 3760798 3761724 . + 0 Mb3425 iunH PROBABLE NUCLEOSIDE HYDROLASE IUNH (PURINE NUCLEOSIDASE) Mb3425, iunH, len: 308 aa. Equivalent to Rv3393,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable iunH,nucleoside hydrolase (EC 3.2.2.-), similar to others e.g. Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA scores: opt: 497, E(): 6e-24, (34.3% identity in 312 aa overlap); Q27546|IUNH_CRIFA from Crithidia fasciculata (314 aa), FASTA scores: opt: 475, E(): 1.4e-22, (31.45% identity in 318 aa overlap); Q9CK67|IUNH from Pasteurella multocida (310 aa), FASTA scores: opt: 464, E(): 6.9e-22,(30.9% identity in 314 aa overlap); Q9A549|CC2615 from Caulobacter crescentus (323 aa), FASTA scores: opt: 464,E(): 7.2e-22, (37.85% identity in 280 aa overlap); etc. Note that also similar to BAB34113|ECS0690 (alias AAG54985|YBEK) PUTATIVE TRNA SYNTHETASE from Escherichia coli strain O157:H7 (311 aa), FASTA scores: opt: 483, E(): 4.5e-23, (33.0% identity in 315 aa overlap). The active site histidine is conserved. Q7TWK1 No intermediary metabolism and respiration Rv3393 NC_002945.3 Mycobrowser_v2 CDS 3761779 3763362 . - 0 Mb3426c CONSERVED HYPOTHETICAL PROTEIN Mb3426c, -, len: 527 aa. Equivalent to Rv3394c,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(99.810% identity in 527 aa overlap). Hypothetical protein, with some similarity to various bacterial proteins e.g. BAB51085|MLR4427 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (545 aa), FASTA scores: opt: 267, E(): 2.8e-08, (26.5% identity in 509 aa overlap); BAB48362|MLR0866 DNA DAMAGE INDUCIBLE PROTEIN P from Rhizobium loti (Mesorhizobium loti) (438 aa), FASTA scores: opt: 245, E(): 4.6e-07, (25.5% identity in 290 aa overlap); Q9S292|SCI11.27c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 202,E(): 0.00012, (28.5% identity in 323 aa overlap); etc. Also similarity with P95102|DINP|RV3056|MTCY22D7.25c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (346 aa), FASTA scores: opt: 211, E(): 3.9e-05, (26.45% identity in 306 aa overlap). Equivalent to AAK47838 from Mycobacterium tuberculosis strain CDC1551 (492 aa) but longer 35 aa. Q7TWK0 No conserved hypotheticals Rv3394c NC_002945.3 Mycobrowser_v2 CDS 3773467 3774519 . - 0 Mb3436c conserved hypothetical protein Mb3436c, -, len: 350 aa. Equivalent to 5' end of Rv3402c, len: 412 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 350 aa overlap). Conserved hypothetical protein, probably involved in cell process, similar to various proteins generally involved in extracellular compounds (lipopolysaccharide O-antigen) biosynthesis e.g. O68392|RFBE PEROSAMINE SYNTHETASE from Brucella melitensis (367 aa), FASTA scores: opt: 420, E(): 1.2e-19, (26.15% identity in 375 aa overlap); Q9L6C1 3,4-DEHYDRATASE-LIKE PROTEIN from Streptomyces antibioticus (393 aa), FASTA scores: opt: 419, E(): 1.5e-19, (30.65% identity in 385 aa overlap); Q9RR26|OLENI DEHYDRATASE from Streptomyces antibioticus (393 aa), FASTA scores: opt: 416, E(): 2.3e-19, (30.65% identity in 385 aa overlap); O33942 ERYCIV PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (401 aa), FASTA scores: opt: 410, E(): 5.6e-19, (31.75% identity in 362 aa overlap); Q9UZI4|ASPB-LIKE1|PAB0774 ASPARTATE AMINOTRANSFERASE (ASPB-LIKE1) from Pyrococcus abyssi (366 aa), FASTA scores: opt: 402, E(): 1.7e-18, (27.05% identity in 377 aa overlap); O88001|WLBC PUTATIVE AMINO-SUGAR BIOSYNTHESIS PROTEIN from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (366 aa),FASTA scores: opt: 394, E(): 5.6e-18, (26.8% identity in 347 aa overlap); Q45378|BPLC DNA FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS from Bordetella pertussis (366 aa), FASTA scores: opt: 393, E(): 6.5e-18, (26.8% identity in 347 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product. X2BN57,Q7TWJ6 No NC_002945.3 Mycobrowser_v2 CDS 3763359 3763973 . - 0 Mb3427c CONSERVED HYPOTHETICAL PROTEIN Mb3427c, -, len: 204 aa. Equivalent to Rv3395c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 204 aa overlap). Conserved hypothetical protein, with some similarity with RECA PROTEINS (RECOMBINASES A) e.g. P16238|RECA_THIFE from Thiobacillus ferrooxidans (346 aa), FASTA scores: opt: 131, E(): 1.1,(31.45% identity in 140 aa overlap); Q59560|RECA_MYCSM from M. smegmatis (349 aa), FASTA scores: opt: 121, E(): 4.4, (30.25% identity in 129 aa overlap); etc. Note that shortened since first submission to avoid overlap with Rv3395A. Equivalent to AAK47839 from Mycobacterium tuberculosis strain CDC1551 (227 aa) but shorter 23 aa. Q7TWJ9 No conserved hypotheticals Rv3395c NC_002945.3 Mycobrowser_v2 CDS 3792822 3794048 . - 0 Mb3457c alr alanine racemase alr Mb3457c, alr, len: 408 aa. Equivalent to Rv3423c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Probable alr, alanine racemase (EC 5.1.1.1), equivalent to P38056|ALR_MYCLE|ML0375|B229_C3_243 ALANINE RACEMASE from Mycobacterium leprae (388 aa), FASTA scores: opt: 2160,E(): 2.3e-124, (84.35% identity in 384 aa overlap). Also highly similar to other alanine racemases e.g. Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa), FASTA scores: opt: 2103, E(): 6.8e-121, (83.6% identity in 384 aa overlap); P94967|ALR_MYCSM from M. smegmatis (389 aa),FASTA scores: opt: 1721, E(): 1.3e-97, (67.25% identity in 385 aa overlap); O86786|ALR_STRCO|SC6G4.23 from Streptomyces coelicolor (391 aa), FASTA scores: opt: 1041,E(): 3.7e-56, (47.65% identity in 380 aa overlap); etc. BELONGS TO THE ALANINE RACEMASE FAMILY. X2BNP3,P0A4X3 No NC_002945.3 Mycobrowser_v2 CDS 3764838 3766415 . - 0 Mb3429c guaA PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] GUAA (GLUTAMINE AMIDOTRANSFERASE) (GMP SYNTHETASE) Mb3429c, guaA, len: 525 aa. Equivalent to Rv3396c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable guaA, gmp synthase (EC 6.3.5.2) (see citation below), equivalent to P46810|GUAA_MYCLE|ML0395|B1620_C2_205 GMP SYNTHASE [GLUTAMINE-HYDROLYZING] from Mycobacterium leprae (529 aa), FASTA scores: opt: 2992, E(): 8.5e-168, (86.85% identity in 525 aa overlap). Also highly similar to others e.g. O52831|GUAA_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (524 aa), FASTA scores: opt: 2636, E(): 5.9e-147, (76.2% identity in 521 aa overlap); Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa),FASTA scores: opt: 2451, E(): 4.1e-136, (71.55% identity in 513 aa overlap); Q9KF78|GUAA_BACHD from Bacillus Halodurans (513 aa), FASTA scores: opt: 1819, E(): 4.1e-99, (52.55% identity in 510 aa overlap); etc. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO THE TYPE-1 GLUTAMINE AMIDOTRANSFERASE FAMILY IN THE N-TERMINAL SECTION. AND BELONGS TO THE GMP SYNTHASE FAMILY IN THE C-TERMINAL SECTION. X2BPF9,P0A5A2 No NC_002945.3 Mycobrowser_v2 CDS 3766427 3767335 . - 0 Mb3430c phyA PROBABLE PHYTOENE SYNTHASE PHYA Mb3430c, phyA, len: 302 aa. Equivalent to Rv3397c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Probable phyA (alternate gene name: crtB), phytoene synthase (EC 2.5.1.-), similar to many e.g. Q9X7V5|SC6A5.09 from Streptomyces coelicolor (312 aa), FASTA scores: opt: 791,E(): 2.8e-43, (48.25% identity in 286 aa overlap); Q9RW07|DR0862 from Deinococcus radiodurans (325 aa), FASTA scores: opt: 482, E(): 1.5e-23, (35.25% identity in 292 aa overlap); Q9JRU9|NMB1168|NMB1130 from Neisseria meningitidis (serogroup B) (290 aa), FASTA scores: opt: 446, E(): 2.8e-21, (34.25% identity in 260 aa overlap); P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419 aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339 PUTATIVE POLY-ISOPRENYL TRANSFERASE (EC 2.5.1.) from Neisseria meningitidis (serogroup A) (290 aa), FASTA scores: opt: 450, E(): 1.6e-21, (34.6% identity in 260 aa overlap). Contains PS01045 Squalene and phytoene synthases signature 2. BELONGS TO THE PHYTOENE/SQUALENE SYNTHETASE FAMILY. X2BN51,P65861 No NC_002945.3 Mycobrowser_v2 CDS 3787520 3787828 . + 0 Mb3450 whiB3 transcriptional regulatory protein whib-like whib3. contains [4fe-4s] cluster. Mb3450, whiB3, len: 102 aa. Equivalent to Rv3416,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). whiB3 (alternate gene name: whmB), WhiB-like regulatory protein (see citations below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_137 PROBABLE TRANSCRIPTION FACTOR WHIB3 from Mycobacterium leprae (102 aa), FASTA scores: opt: 657, E(): 7.9e-39, (86.25% identity in 102 aa overlap). Also highly similar to Q9Z6E9|WHIB3 from Mycobacterium smegmatis (96 aa), FASTA scores: opt: 604, E(): 3.5e-35, (80.4% identity in 102 aa overlap); and O88103|WHID|SC6G4.45c|WBLB from Streptomyces coelicolor (112 aa), FASTA scores: opt: 437, E(): 1.4e-23,(62.5% identity in 96 aa overlap). Also similar to O05847|WHIB1|Rv3219|MTCY07D11.07c from Mycobacterium tuberculosis (84 aa), FASTA scores: opt: 215, E(): 2.5e-08, (44.45% identity in 81 aa overlap). Note that primer extension analysis revealed three transcriptional start sites and that expression from the three potential promoters is growth phase-dependent (see third citation). X2BPI5,Q7TWJ2 No NC_002945.3 Mycobrowser_v2 CDS 3776508 3777212 . - 0 Mb3438c CONSERVED HYPOTHETICAL PROTEIN Mb3438c, -, len: 234 aa. Equivalent to Rv3404c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Conserved hypothetical protein, some similarity to several METHIONYL-TRNA FORMYLTRANSFERASES e.g. BAB51418|MLL4854 from Rhizobium loti (Mesorhizobium loti) (317 aa), FASTA scores: opt: 210, E(): 1.7e-06, (27.55% identity in 178 aa overlap); P94463|FMT_BACSU from Bacillus subtilis (317 aa), FASTA scores: opt: 199 ,E(): 8.8e-06, (28.25% identity in 177 aa overlap); O51091||FMT_BORBU|BB0064 from Borrelia burgdorferi (Lyme disease spirochete) (312 aa),FASTA scores: opt: 187, E(): 5.2e-05, (30.2% identity in 192 aa overlap); etc. X2BNC5,P65074 No conserved hypotheticals Rv3404c NC_002945.3 Mycobrowser_v2 CDS 3777330 3777896 . - 0 Mb3439c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb3439c, -, len: 188 aa. Equivalent to Rv3405c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Possible transcriptional regulator, showing weak similarity to other bacterial regulatory proteins e.g. Q9KE70|BH0987 from Bacillus halodurans (203 aa), FASTA scores: opt: 168,E(): 0.0016, (34.8% identity in 92 aa overlap); Q9A5F7|CC2493 Caulobacter crescentus (204 aa), FASTA scores: opt: 160, E(): 0.0051, (32.6% identity in 89 aa overlap); Q9RDR0|SC4A7.02 from Streptomyces coelicolor (227 aa), FASTA scores: opt: 159, E(): 0.0064, (37.0% identity in 189 aa overlap); etc. Also some similarity to hypothetical Mycobacterium tuberculosis regulatory proteins e.g. O05858|Rv3208|MTCY07D11.18c, MTCI125_6,MTCY7D11_18, MTCY10G2_30; etc. Contains potential helix-turn-helix motif from aa 39-60 (+2.97 SD). X2BNW8,P67443 No regulatory proteins Rv3405c NC_002945.3 Mycobrowser_v2 CDS 3767364 3768443 . - 0 Mb3431c idsA1 PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE): DIMETHYLALLYLTRANSFERASE (PRENYLTRANSFERASE) (GERANYL-DIPHOSPHATE SYNTHASE) + GERANYLTRANSTRANSFERASE (FARNESYL-DIPHOSPHATE SYNTHASE) (FARNESYL-PYROPHOSPHATE SYNTHETASE) (FARNESYL DIPHOSPHATE SYNTHETASE) (FPP SYNTHETASE) + FARNESYLTRANSTRANSFERASE (GERANYLGERANYL-DIPHOSPHATE SYNTHASE) Mb3431c, idsA1, len: 359 aa. Equivalent to Rv3398c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable idsA1,geranylgeranyl pyrophosphate synthetase (GGPP synthetase) including: dimethylallyltransferase (EC 2.5.1.1),geranyltranstransferase (EC 2.5.1.10), and farnesyltranstransferase (EC 2.5.1.29). Most similar to AE000797_3|O26156|Q53479 bifunctional short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrop (325 aa), FASTA scores: opt: 605, E(): 0,(37.1% identity in 329 aa overlap); homology suggests ATG at 30121 or TTG at 30145 to be the initiation codon. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY; BELONGS TO A FAMILY THAT GROUPS TOGETHER FPP SYNTHETASE, GGPP SYNTHETASE AND HEXAPRENYL PYROPHOSPHATE SYNTHETASE. Note that previously known as idsA. X2BNK9,P0A5H9 No NC_002945.3 Mycobrowser_v2 CDS 3768466 3769512 . + 0 Mb3432 possible s-adenosylmethionine-dependent methyltransferase Mb3432, -, len: 348 aa. Equivalent to Rv3399, len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 348 aa overlap). Hypothetical protein,similar to other Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c (367 aa), FASTA scores: opt: 1188, E(): 7.7e-69, (60.05% identity in 308 aa overlap); MTCY31.21c (38.0% identity in 308 aa overlap), MTV041_5,MTCY4C12_14, MTY13D12_21, MTV043_22, MTCY210_44, MTCI5_19,MTCI5_20, MTV035_9, MTCY180_22, MTCY31_23, MTY13D12_1,MTCY180_29; etc. X2BNB9,P59986 No lipid metabolism Rv3399 NC_002945.3 Mycobrowser_v2 CDS 3840431 3840727 . + 0 Mb3504 PE31 pe family protein pe31 Mb3504, PE31, len: 98 aa. Equivalent to Rv3477,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 98 aa overlap). Member of the M. tuberculosis PE family, similar to O53941|Rv1791|MTV049.13 (99 aa), FASTA scores: opt: 373, E(): 4.3e-18, (64.65% identity in 99 aa overlap); MTCI364.07; MTCY21C12.10c; MTCY1A11.25c; MTC1A11.04; MTCY359.33; etc. Q7TWF6 No PE/PPE Rv3477 NC_002945.3 Mycobrowser_v2 CDS 3777958 3778845 . + 0 Mb3440 PROBABLE DIOXYGENASE Mb3440, -, len: 295 aa. Equivalent to Rv3406, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Probable dioxygenase (EC 1.-.-.-), highly similar to Q9WWU|ATSK PUTATIVE ALPHA-KETOGLUTARATE DEPENDENT DIOXYGENASE from Pseudomonas putida (301 aa), FASTA scores: opt: 994, E(): 3.9e-57,(53.7% identity in 283 aa overlap); Q9I6U1|PA0193 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa),FASTA scores: opt: 1024, E(): 4.4e-59, (53.65% identity in 287 aa overlap); Q9HX81|TAUD|PA3935 TAURINE DIOXYGENASE from Pseudomonas aeruginosa (277 aa), FASTA scores: opt: 599, E(): 1.4e-31, (39.35% identity in 277 aa overlap); and similar to other dioxygenases e.g. AAG54718|TAUD (alias BAB33845|ECS0422) TAURINE DIOXYGENASE 2-OXOGLUTARATE-DEPENDENT from Escherichia coli strain O157:H7 (283 aa), FASTA scores: opt: 595, E(): 2.5e-31,(38.1% identity in 281 aa overlap); etc. BELONGS TO THE TFDA FAMILY OF DIOXYGENASES. X2BPH3,P65076 No intermediary metabolism and respiration Rv3406 NC_002945.3 Mycobrowser_v2 CDS 3778880 3779179 . + 0 Mb3441 vapb47 possible antitoxin vapb47 Mb3441, -, len: 99 aa. Equivalent to Rv3407, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Hypothetical protein,similar to other hypothetical proteins from M. tuberculosis strains H37Rv and CDC1551 e.g. AAK46285|MT2013 (90 aa), FASTA scores: opt: 160, E(): 0.00021, (37.1% identity in 89 aa overlap); O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 155, E(): 0.00051, (41.05% identity in 78 aa overlap),MTCY19H5.26, MTCY20H10.07, MTI376.09c, MTCY427.21, etc. X2BN63 No virulence, detoxification, adaptation Rv3407 NC_002945.3 Mycobrowser_v2 CDS 3779619 3781355 . - 0 Mb3443c choD cholesterol oxidase chod (cholesterol-o2 oxidoreductase) Mb3443c, choD, len: 578 aa. Equivalent to Rv3409c,len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 578 aa overlap). Probable choD,cholesterol oxidase precursor (EC 1.1.3.6), equivalent to Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae (569 aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6% identity in 569 aa overlap). Also highly similar to Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101,E(): 5.2e-57, (60.05% identity in 586 aa overlap); and similar to other oxidoreductases e.g. Q9A7T6|CC1634 OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2% identity in 583 aa overlap). BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN. Contains PS00017 ATP/GTP-binding site motif A. Q7TWJ4 No NC_002945.3 Mycobrowser_v2 CDS 3781411 3782538 . - 0 Mb3444c guaB3 PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB3 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD) Mb3444c, guaB3, len: 375 aa. Equivalent to Rv3410c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Probable guaB3,inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), equivalent to Q49721|YY10_MYCLE|ML0388|B1620_C2_193 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium leprae (375 aa), FASTA scores: opt: 2182, E(): 9.5e-122, (90.6% identity in 373 aa overlap). Highly similar to Q9RHY9 GUAB ORF GENES FOR IMP DEHYDROGENASE, HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (376 aa), FASTA scores: opt: 1490, E(): 7.6e-81, (61.0% identity in 382 aa overlap); Q9L0I6|SCD63.03 PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1275, E(): 3.8e-68, (52.95% identity in 372 aa overlap); P73853|GUAB|SLR1722 IMP DEHYDROGENASE SUBUNIT from Synechocystis sp. strain PCC 6803 (387 aa), FASTA scores: opt: 882, E(): 6.7e-45, (41.3% identity in 373 aa overlap); and similar to other inosine-5'-monophosphate dehydrogenases e.g. P44334|IMDH_HAEIN|GUAB|HI0221 from Haemophilus influenzae (488 aa), FASTA scores: opt: 267,E(): 1.8e-08, (34.25% identity in 216 aa overlap); etc. Also highly similar to the C-terminus of Q50753|GUAA/B HOMOLOGY TO Mycobacterium leprae GUAA (FRAGMENT) from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 506, E(): 4.6e-23, (85.05% identity in 87 aa overlap). SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO GMP REDUCTASE. X2BNX6,P65171 No NC_002945.3 Mycobrowser_v2 CDS 3846116 3846805 . - 0 Mb3511c PROBABLE INTEGRAL MEMBRANE PROTEIN Mb3511c, -, len: 229 aa. Equivalent to Rv3481c,len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Probable integral membrane protein. No real similarity with others. Q7TWF0 No cell wall and cell processes Rv3481c NC_002945.3 Mycobrowser_v2 CDS 3782558 3784147 . - 0 Mb3445c guaB2 PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB2 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD) Mb3445c, guaB2, len: 529 aa. Equivalent to Rv3411c,len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 529 aa overlap). Probable guaB2,inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), equivalent to Q49729|IMDH_MYCLE|GUAB|ML0387|B1620_C3_238 INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE from Mycobacterium leprae (529 aa), FASTA scores: opt: 3154, E(): 4.4e-165,(92.45% identity in 529 aa overlap). Highly similar to other inosine-5'-monophosphate dehydrogenases e.g. Q9RHZ0|GUAB from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (506 aa), FASTA scores: opt: 2284, E(): 1.5e-117, (67.9% identity in 505 aa overlap); Q9L0I7|SCD63.02 from Streptomyces coelicolor (501 aa),FASTA scores: opt: 2178, E(): 9e-112, (67.2% identity in 491 aa overlap); O67820|IMDH_AQUAE|GUAB|AQ_2023 from Aquifex aeolicus (490 aa), FASTA scores: opt: 1820, E(): 3.2e-92, (58.1% identity in 487 aa overlap); etc. Also similar to Q50716|YY10_MYCTU|Rv3410c|MT3518|MTCY78.18 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium tuberculosis (38.6% identity in 158 aa overlap). Contains PS00487 IMP dehydrogenase / GMP reductase signature. SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO GMP REDUCTASE. X2BPI0,P65168 No NC_002945.3 Mycobrowser_v2 CDS 3784354 3784764 . + 0 Mb3446 CONSERVED HYPOTHETICAL PROTEIN Mb3446, -, len: 136 aa. Equivalent to Rv3412, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Hypothetical protein,strongly similar only to Q49742|YY12_MYCLE|ML0386|B1620_F3_131 HYPOTHETICAL 15.3 KDA PROTEIN from Mycobacterium leprae (137 aa), FASTA scores: opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa overlap). X2BN69 No conserved hypotheticals Rv3412 NC_002945.3 Mycobrowser_v2 CDS 3784774 3785673 . - 0 Mb3447c unknown alanine and proline rich protein Mb3447c, -, len: 299 aa. Equivalent to Rv3413c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Hypothetical unknown ala-, pro-rich protein. X2BNM8,P65082 No conserved hypotheticals Rv3413c NC_002945.3 Mycobrowser_v2 CDS 3794342 3794704 . - 0 Mb3458c HYPOTHETICAL PROTEIN Mb3458c, -, len: 120 aa. Equivalent to Rv3424c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). Hypothetical unknown protein. X2BNE5 No conserved hypotheticals Rv3424c NC_002945.3 Mycobrowser_v2 CDS 3785666 3786304 . - 0 Mb3448c sigD PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA-D FACTOR SIGD Mb3448c, sigD, len: 212 aa. Equivalent to Rv3414c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 212 aa overlap). Probable sigD,alternative RNA polymerase sigma-D factor (see citation below), similar to others (notably from Streptomyces coelicolor) e.g. Q9L0I8|SCD63.01 from Streptomyces coelicolor (195 aa), FASTA scores: opt: 533, E(): 9.6e-28,(47.25% identity in 182 aa overlap); Q9FDS3|ADSA from Streptomyces griseus (258 aa), FASTA scores: opt: 223,E(): 1.8e-07, (28.95% identity in 183 aa overlap); BAB48649|MLL1224 from Rhizobium loti (Mesorhizobium loti) (187 aa), FASTA scores: opt: 202, E(): 3.2e-06, (30.4% identity in 194 aa overlap); P38133|RPOE_STRCO|SIGE|SCE94.07 from Streptomyces coelicolor (176 aa), FASTA scores: opt: 200, E(): 4.1e-06,(35.25% identity in 156 aa overlap); P37978|CNRH_ALCEU from Alcaligenes eutrophus (Ralstonia eutropha), FASTA scores: opt: 197, E(): 6.9e-06, (30.35% identity in 191 aa overlap); etc. C-terminus strongly similar to N-terminal part of Q49727|S1620B|B1620_C3_233 HYPOTHETICAL 6.2 KDA PROTEIN from Mycobacterium leprae (59 aa), FASTA scores: opt: 217, E(): 1.3e-07, (90.25% identity in 41 aa overlap). BELONGS TO THE SIGMA-70 FACTOR FAMILY. X2BND5,P66812 No NC_002945.3 Mycobrowser_v2 CDS 3786322 3787149 . - 0 Mb3449c CONSERVED HYPOTHETICAL PROTEIN Mb3449c, -, len: 275 aa. Equivalent to Rv3415c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Conserved hypothetical protein, equivalent to Q9CCV3|ML0383 HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa),FASTA scores: opt: 1278, E(): 4.2e-71, (73.5% identity in 279 aa overlap); and Q49858|B229_C1_175 HYPOTHETICAL 27.4 KDA PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1186, E(): 1.7e-65, (74.05% identity in 258 aa overlap). And C-terminus highly similar to N-terminal part of Q49726|B1620_C3_232 HYPOTHETICAL 12.9 KDA PROTEIN from Mycobacterium leprae (122 aa), FASTA scores: opt: 580, E(): 1.1e-28, (74.6% identity in 126 aa overlap). Also some similarity with P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26 RIBOFLAVIN BIOSYNTHESIS PROTEIN R (339 aa), FASTA scores: opt: 143, E(): 0.13, (28.25% identity in 184 aa overlap). Q7TWJ3 No conserved hypotheticals Rv3415c NC_002945.3 Mycobrowser_v2 CDS 3787900 3789519 . - 0 Mb3451c groEL1 60 KDA CHAPERONIN 1 GROEL1 (PROTEIN CPN60-1) (GROEL PROTEIN 1) Mb3451c, groEL1, len: 539 aa. Equivalent to Rv3417c, len: 539 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 539 aa overlap). groEL1 (alternate genbe name: cpn60_1), 60 kd chaperonin 1 (protein cpn60 1) (see citations below), equivalent to P37578|CH61_MYCLE|B1620_C3_228|GROL1|GROEL1|GROEL-1|GROE1|ML0381|B229_ 60 KDA CHAPERONIN 1 from Mycobacterium leprae (537 aa), FASTA scores: opt: 2846,E(): 1.5e-154, (82.95% identity in 539 aa overlap). Also highly similar to others e.g. Q00767|CH61_STRAL|GROL1|GROEL1 from Streptomyces albus G (539 aa), FASTA scores: opt: 2130, E(): 8.1e-114, (61.9% identity in 541 aa overlap); P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces coelicolor (540 aa), FASTA scores: opt: 2119, E(): 3.4e-113, (61.8% identity in 542 aa overlap); etc. Also similar to P06806|CH62_MYCTU|Q48931|Rv0440|MTV037.04|GROL2|GROEL2|GRO EL-2|HSP65 (62.2% identity in 527 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, PS00296 Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY. X2BN75,P0A519 No virulence, detoxification, adaptation Rv3417c NC_002945.3 Mycobrowser_v2 CDS 3789614 3789916 . - 0 Mb3452c groES 10 KDA CHAPERONIN GROES (PROTEIN CPN10) (PROTEIN GROES) (BCG-A HEAT SHOCK PROTEIN) (10 KDA ANTIGEN) Mb3452c, groES, len: 100 aa. Equivalent to Rv3418c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). groES (alternate gene names: cpn10, mpt57), 10 kDa chaperonin (protein cpn10) (see citations below), equivalent to P24301|CH10_MYCLE|MOPB|GROES|CHPA|ML0380|B1620_C3_227|B229 _C3_247 from Mycobacterium leprae (99 aa), FASTA scores: opt: 568, E(): 2.1e-31, (89.9% identity in 99 aa overlap). And also strongly identical to others e.g. O86017|CH10_MYCAV|MOPB|GROES from Mycobacterium avium and Mycobacterium paratuberculosis (99 aa), FASTA scores: opt: 611, E(): 2.9e-34, (96.95% identity in 99 aa overlap); P15020|CH10_MYCBO|MOPB|GROES from Mycobacterium bovis (99 aa), FASTA scores: opt: 596, E(): 2.9e-33, (98.95% identity in 94 aa overlap); P40172|CH10_STRCO|GROES|SC6G4.39 from Streptomyces coelicolor and Streptomyces lividans (102 aa), FASTA scores: opt: 480, E(): 1.6e-25, (76.75% identity in 99 aa overlap); etc. Also identical to MSG10KAG_1, MT10KAG_1,MTBCGA_1. Contains PS00681 Chaperonins cpn10 signature. BELONGS TO THE GROES CHAPERONIN FAMILY. X2BNN5,P15020 No NC_002945.3 Mycobrowser_v2 CDS 3790183 3791217 . - 0 Mb3453c gcp PROBABLE O-SIALOGLYCOPROTEIN ENDOPEPTIDASE GCP (GLYCOPROTEASE) Mb3453c, -, len: 344 aa. Equivalent to Rv3419c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable gcp,glycoprotease (EC 3.4.24.57), equivalent to P37969|GCP_MYCLE|GCP|ML0379|U229E|U1620c|B229_C3_246|B1620 _C3_226 PROBABLE GLYCOPROTEASE from Mycobacterium leprae (351 aa), FASTA scores: opt: 1898, E(): 2.4e-101, (86.1% identity in 345 aa overlap). Highly similar to others e.g. O86793|GCP_STRCO|GCP|SC6G4.30 from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1282, E(): 4.1e-66, (60.45% identity in 344 aa overlap); Q9WXZ2|TM0145 from Thermotoga maritima (327 aa), FASTA scores: opt: 867, E(): 1.9e-42,(45.4% identity in 337 aa overlap); P05852|GCP_ECOLI|B3064 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 838, E(): 9e-41, (46.55% identity in 346 aa overlap); etc. Shows some similarity to Q50707|YY21_MYCTU|Rv3421c|MTCY78.08 (33.9% identity in 127 aa overlap). Contains PS01016 Glycoprotease family signature. BELONGS TO PEPTIDASE FAMILY M22; ALSO KNOWN AS THE GLYCOPROTEASE FAMILY. X2BNE0,P65802 No intermediary metabolism and respiration Rv3419c NC_002945.3 Mycobrowser_v2 CDS 3791214 3791690 . - 0 Mb3454c rimI ribosomal-protein-alanine acetyltransferase rimi (acetylating enzyme for n-terminal of ribosomal protein s18) Mb3454c, rimI, len: 158 aa. Equivalent to Rv3420c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Probable rimI,ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), equivalent to C-terminal part of Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: opt: 772, E(): 2.7e-44, (72.1% identity in 154 aa overlap). Similar notably to ribosomal-protein-alanine acetyltransferases e.g. Q9AC11|CC0058 from Caulobacter crescentus (150 aa), FASTA scores: opt: 223, E(): 4.9e-08,(37.5% identity in 136 aa overlap); Q9KFD4|BH0547 from Bacillus halodurans (151 aa), FASTA scores: opt: 222, E(): 5.8e-08, (35.2% identity in 142 aa overlap); Q9PG61|XF0441 from Xylella fastidiosa (156 aa), FASTA scores: opt: 207,E(): 5.9e-07, (32.2% identity in 149 aa overlap); Q9HVB7|RIMI|PA4678 from Pseudomonas aeruginosa (150 aa),FASTA scores: opt: 203, E(): 1.1e-06, (32.45% identity in 151 aa overlap); P09453|RIMI_ECOLI|B4373 from Escherichia coli strain K12 (148 aa), FASTA scores: opt: 196, E(): 3.1e-06, (33.55% identity in 149 aa overlap); etc. BELONGS TO THE ACETYLTRANSFERASE FAMILY, RIMI SUBFAMILY. Q7TWJ1 No NC_002945.3 Mycobrowser_v2 CDS 3811018 3812232 . - 0 Mb3476c HYPOTHETICAL ALANINE AND VALINE RICH PROTEIN Mb3476c, -, len: 404 aa. Equivalent to Rv3446c,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 404 aa overlap). Hypothetical unknown ala-, val-rich protein. Q7TWH6 No conserved hypotheticals Rv3446c NC_002945.3 Mycobrowser_v2 CDS 3805099 3805941 . + 0 Mb3468 conserved protein Mb3468, -, len: 280 aa. Equivalent to Rv3438, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, equivalent to Q9CCV6|ML0370 HYPOTHETICAL PROTEIN from Mycobacterium leprae (289 aa),FASTA scores: opt: 1491, E(): 9.2e-81, (79.85% identity in 283 aa overlap); and highly similar (but shorter 41 aa) to Q49872|B229_F1_20 HYPOTHETICAL 34.0 KDA PROTEIN from Mycobacterium leprae (324 aa), FASTA scores: opt: 1491,E(): 1e-80, (79.85% identity in 283 aa overlap). Shows some similarity to Q9KIU3|LIPA LIPASE from plasmid pAH114 uncultured bacterium (281 aa), FASTA scores: opt: 168,E(): 0.0081, (29.3% identity in 140 aa overlap). Q7TWI2 No conserved hypotheticals Rv3438 NC_002945.3 Mycobrowser_v2 CDS 3791687 3792322 . - 0 Mb3455c CONSERVED HYPOTHETICAL PROTEIN Mb3455c, -, len: 211 aa. Equivalent to Rv3421c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (GLYCOPROTEASE FAMILY PROTEIN) from Caulobacter crescentus (211 aa),FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa overlap); Q9KQK9|VC1989 from Vibrio cholerae (237 aa),FASTA scores: opt: 238, E(): 8.2e-07, (28.85% identity in 208 aa overlap); BAB51966|Mlr5530 from Rhizobium loti (Mesorhizobium loti) (225 aa), FASTA scores: opt: 237,E(): 9e-07, (35.0% identity in 220 aa overlap); etc. Some similarity to upstream Q50709|GCP_MYCTU|Rv3419c|MT3528|MTCY78.10 from M. tuberculosis (344 aa), (33.9% identity in 127 aa overlap). X2BPJ0,P65084 No conserved hypotheticals Rv3421c NC_002945.3 Mycobrowser_v2 CDS 3792319 3792825 . - 0 Mb3456c CONSERVED HYPOTHETICAL PROTEIN Mb3456c, -, len: 168 aa. Equivalent to Rv3422c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Conserved hypothetical protein, equivalent to Q49864|YY22_MYCLE|ML0377|U229F|B229_C2_205 HYPOTHETICAL 17.6 KDA PROTEIN from Mycobacterium leprae (161 aa), FASTA scores: opt: 752, E(): 8.3e-38, (77.4% identity in 146 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces coelicolor (148 aa), FASTA scores: opt: 377, E(): 1.2e-15,(50.85% identity in 120 aa overlap); Q9X1W7|TM1632 from Thermotoga maritima (161 aa), FASTA scores: opt: 247, E(): 6.2e-08, (39.4% identity in 137 aa overlap); Q9RRY1|DR2351 from Deinococcus radiodurans (148 aa), FASTA scores: opt: 236, E(): 2.6e-07, (38.6% identity in 127 aa overlap); etc. Contains PS00017 ATP /GTP-binding site motif A. X2BN80,P67172 No conserved hypotheticals Rv3422c NC_002945.3 Mycobrowser_v2 CDS 3794867 3795403 . + 0 Mb3459 PPE57 ppe family protein ppe57 Mb3459, PPE57, len: 178 aa. Equivalent to 5' end of Rv3425, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv, (90.9% identity in 176 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 781, E(): 7e-44, (69.9% identity in 176 aa overlap); and downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity in 125 aa overlap); MTV049_11, MTCY428_16, MTV049_22,MTV049_30, MTCY261_4; etc. Rv3429: Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end)); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58,Rv3427c, Rv3428c and PPE59 compared to Mycobacterium tuberculosis strain H37Rv. Q7TWJ0 No NC_002945.3 Mycobrowser_v2 CDS 3796996 3797841 . - 0 Mb3461c possible transposase (fragment) Mb3461c, -, len: 281 aa. Equivalent to Rv3431c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Possible truncated transposase for IS1552, similar to, but shorter than other transposases e.g. P72303 from Rhodococcus opacus (418 aa),FASTA scores: opt: 1509, E(): 1.2e-91, (80.95% identity in 278 aa overlap); Q9AKV5 from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 1115, E(): 7.8e-66, (63.45% identity in 268 aa overlap); etc. Q7TWI8 No insertion seqs and phages Rv3431c NC_002945.3 Mycobrowser_v2 CDS 3798074 3799456 . - 0 Mb3462c gadB PROBABLE GLUTAMATE DECARBOXYLASE GADB Mb3462c, gadB, len: 460 aa. Equivalent to Rv3432c,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 460 aa overlap). Probable gadB,glutamate decarboxylase (EC 4.1.1.15), similar to many e.g. P73043|GAD|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99,(55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|GAD from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15% identity in 437 aa overlap); etc. BELONGS TO GROUP II DECARBOXYLASES (DDC, GAD, HDC AND TYRDC). Q7TWI7 No NC_002945.3 Mycobrowser_v2 CDS 3799494 3800915 . - 0 Mb3463c conserved protein Mb3463c, -, len: 473 aa. Equivalent to Rv3433c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 473 aa overlap). Hypothetical protein,member of YKL151c/yjeF family, equivalent to P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 HYPOTHETICAL 47.2 KDA PROTEIN from Mycobacterium leprae (473 aa), FASTA scores: opt: 2650, E(): 5e-136, (84.55% identity in 473 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa),FASTA scores: opt: 700, E(): 1.2e-30, (33.7% identity in 484 aa overlap); O86783|SC6G4.20c from Streptomyces coelicolor (485 aa), FASTA scores: opt: 563, E(): 3.2e-23,(48.45% identity in 489 aa overlap); Q9LC81 from Arthrobacter sp. Q36 (313 aa), FASTA scores: opt: 553,E(): 7.9e-23, (44.2% identity in 303 aa overlap); etc. Contains PS01049 Hypothetical YKL151c/yjeF family signature 1, PS01050 Hypothetical YKL151c/yjeF family signature 2. Q7TWI6 No conserved hypotheticals Rv3433c NC_002945.3 Mycobrowser_v2 CDS 3800917 3801630 . - 0 Mb3464c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb3464c, -, len: 237 aa. Equivalent to Rv3434c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 237 aa overlap). Possible conserved transmembrane protein, showing some similarity with Q9CGH7|YLDB HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (258 aa), FASTA scores: opt: 248, E(): 1.6e-09, (28.8% identity in 198 aa overlap); and P94983|Rv1648|MTCY06H11.13 from Mycobacterium tuberculosis (268 aa), FASTA scores: opt: 205, E(): 1.2e-06, (31.45% identity in 194 aa overlap). Q7TWI5 No cell wall and cell processes Rv3434c NC_002945.3 Mycobrowser_v2 CDS 3816053 3817456 . + 0 Mb3478 eccd4 esx conserved component eccd4. esx-4 type vii secretion system protein. probable integral membrane protein. Mb3478, -, len: 467 aa. Equivalent to Rv3448, len: 467 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 467 aa overlap). Probable conserved integral membrane protein, showing some similarity with Q9CD35|ML2529 from Mycobacterium leprae (485 aa), FASTA scores: opt: 371, E(): 3.6e-14, (27.25% identity in 481 aa overlap); and two proteins from Mycobacterium tuberculosis O86362|Rv0290|MTV035.18 (472 aa), FASTA scores: opt: 429,E(): 1.6e-17, (28.6% identity in 479 aa overlap); and O05457|Rv3887c|MTCY15F10.25 (509 aa), FASTA scores: opt: 203, E(): 0.00019, (25.6% identity in 492 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Q7TWH4 No cell wall and cell processes Rv3448 NC_002945.3 Mycobrowser_v2 CDS 3802717 3804591 . - 0 Mb3466c glmS PROBABLE GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] GLMS (HEXOSEPHOSPHATE AMINOTRANSFERASE) (D-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE) (GFAT) (L-GLUTAMINE-D-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE) (GLUCOSAMINE-6-PHOSPHATE SYNTHASE) Mb3466c, glmS, len: 624 aa. Equivalent to Rv3436c,len: 624 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 624 aa overlap). Probable glmS,glucosamine--fructose-6-phosphate aminotransferase (EC 2.6.1.16), equivalent to P40831|GLMS_MYCLE|ML0371|B229_C3_238 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] from Mycobacterium leprae (623 aa), FASTA scores: opt: 3584, E(): 4.7e-214, (89.3% identity in 627 aa overlap). Also highly similar to others e.g. O68956|GLMS_MYCSM from Mycobacterium smegmatis (627 aa),FASTA scores: opt: 3517, E(): 6.5e-210, (87.25% identity in 627 aa overlap); O86781|GLMS_STRCO|SC6G4.18 from Streptomyces coelicolor (614 aa), FASTA scores: opt: 2364,E(): 1.3e-138, (64.95% identity in 625 aa overlap); Q9K1P9|NMB0031 from Neisseria meningitidis (serogroup B) and Q9JWN9|GLMS|NMA0276 from Neisseria meningitidis (serogroup A) (612 aa), FASTA scores: opt: 1445, E(): 8.4e-82, (43.55% identity in 627 aa overlap); etc. BELONGS TO THE TYPE-2 GATASE DOMAIN IN THE N-TERMINAL SECTION. BELONGS TO THE SIS FAMILY, GLMS SUBFAMILY, IN THE C-TERMINAL SECTION. X2BNB0,P0A589 No NC_002945.3 Mycobrowser_v2 CDS 3804613 3805089 . + 0 Mb3467 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb3467, -, len: 158 aa. Equivalent to Rv3437, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 158 aa overlap). Possible conserved transmenbrane protein, C-terminus similar to N-terminal part of O06345|Rv3482c|MTCY13E12.35c HYPOTHETICAL 28.5 KDA PROTEIN from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 140, E(): 0.1, (58.8% identity in 34 aa overlap); and Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from Streptomyces (347 aa), coelicolor FASTA scores: opt: 112, E(): 6.8, (50.0% identity in 32 aa overlap). Questionable ORF. Q7TWI3 No cell wall and cell processes Rv3437 NC_002945.3 Mycobrowser_v2 CDS 3805961 3807364 . - 0 Mb3469c CONSERVED HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN Mb3469c, -, len: 467 aa. Equivalent to Rv3439c,len: 467 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 467 aa overlap). Conserved hypothetical ala-, pro-rich protein, similar in part to N-terminal part of Q49853|B229_C1_154 HYPOTHETICAL 11.2 KDA PROTEIN from Mycobacterium leprae (103 aa), FASTA scores: opt: 265, E(): 0.0013, (51.1% identity in 90 aa overlap). Q7TWI1 No conserved hypotheticals Rv3439c NC_002945.3 Mycobrowser_v2 CDS 3807726 3809072 . - 0 Mb3471c mrsA PROBABLE PHOSPHO-SUGAR MUTASE / MRSA PROTEIN HOMOLOG Mb3471c, mrsA, len: 448 aa. Equivalent to Rv3441c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Probable mrsA,phosphoglucomutase or phosphomannomutase (EC 5.4.2.-),equivalent to Q49869|URED|B229_C3_234 MRSA PROTEIN HOMOLOG from Mycobacterium leprae (463 aa), FASTA scores: opt: 2449, E(): 6.3e-135, (87.65% identity in 445 aa overlap); and highly similar (but longer 178 aa) to Q49862|UREC|B229_C2_192 PUTATIVE UREASE OPERON UREC PROTEIN from Mycobacterium leprae (288 aa), FASTA scores: opt: 1442, E(): 1.3e-76, (86.5% identity in 267 aa overlap). Highly similar to phospho-sugar mutases e.g. Q53876|SC6G4.14 PUTATIVE PHOSPHO-SUGAR MUTASE (SIMILAR TO PHOSPHOMANNOMUTASES) from Streptomyces coelicolor (452 aa), FASTA scores: opt: 1710, E(): 5e-92, (60.45% identity in 450 aa overlap); Q9KG46|BH0267 PHOSPHOGLUCOSAMINE MUTASE from Bacillus halodurans (447 aa), FASTA scores: opt: 1351, E(): 3.5e-71, (48.4% identity in 444 aa overlap); BAB58323|GLMM PHOSPHOGLUCOSAMINE-MUTASE from Staphylococcus aureus subsp. aureus Mu50 (451 aa) and Q99QR5|GLMM(FEMD)|SA1965 PHOSPHOGLUCOSAMINE-MUTASE from Staphylococcus aureus subsp. aureus N315. (451 aa), FASTA scores: opt: 1315, E(): 4.3e-69, (48.45% identity in 446 aa overlap); P95685|FEMD|GLMM PHOSPHOGLUCOSAMINE-MUTASE (451 aa), FASTA scores: opt: 1310, E(): 8.5e-69, (48.2% identity in 446 aa overlap); P95575|MRSA_PSESY MRSA PROTEIN HOMOLOG from Pseudomonas syringae (pv. syringae) (447 aa), FASTA scores: opt: 1143, E(): 4.2e-59, (42.75% identity in 447 aa overlap); etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. X2BNC0,Q7TWH9 No NC_002945.3 Mycobrowser_v2 CDS 3821153 3821833 . + 0 Mb3482 cut4 PROBABLE CUTINASE PRECURSOR CUT4 Mb3482, cut4, len: 226 aa. Equivalent to Rv3452,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Probable cut4,cutinase precursor (EC 3.1.1.-), similar to other e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 522, E(): 7.3e-24, (46.6% identity in 221 aa overlap); P30272|CUTI_MAGGR|CUT1 from Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) (228 aa), FASTA scores: opt: 205, E(): 3.8e-05, (29.25% identity in 164 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 204,E(): 3.9e-05, (33.5% identity in 209 aa overlap); etc. Similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 773, E(): 1.3e-38, (59.35% identity in 209 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 704, E(): 1.3e-34, (53.4% identity in 219 aa overlap); etc. Contains PS00155 Cutinase, serine active site. BELONGS TO THE CUTINASE FAMILY. Alternative start possible at 4553 in cSCY13E12 but no RBS. Q7TWH1 No cell wall and cell processes Rv3452 NC_002945.3 Mycobrowser_v2 CDS 3809197 3809652 . - 0 Mb3472c rpsI 30s ribosomal protein s9 rpsi Mb3472c, rpsI, len: 151 aa. Equivalent to Rv3442c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Probable rpsI,ribosomal protein S9, equivalent to P40828|RS9_MYCLE|ML0365|B229_C2_191 30S RIBOSOMAL PROTEIN S9 (153 aa), FASTA scores: opt: 800, E(): 2.1e-42, (83.85% identity in 155 aa overlap). Also highly similar to others e.g. Q53875|RS9_STRCO|SC6G4.13 from Streptomyces coelicolor (170 aa), FASTA scores: opt: 533, E(): 5.7e-26,(60.75% identity in 135 aa overlap); Q9KGD4|RPSI|BH0169 (BS10) from Bacillus halodurans (130 aa), FASTA scores: opt: 469, E(): 3.8e-22, (58.65% identity in 121 aa overlap); Q9CDG7|RPSI from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (130 aa), FASTA scores: opt: 451, E(): 4.9e-21, (58.65% identity in 121 aa overlap); P07842|RS9_BACST|RPSI from Bacillus stearothermophilus (129 aa), FASTA scores: opt: 448, E(): 7.4e-21, (54.55% identity in 121 aa overlap); etc. Contains PS00360 Ribosomal protein S9 signature. BELONGS TO THE S9P FAMILY OF RIBOSOMAL PROTEINS. X2BNU0,P66640 No NC_002945.3 Mycobrowser_v2 CDS 3809649 3810092 . - 0 Mb3473c rplM 50s ribosomal protein l13 rplm Mb3473c, rplM, len: 147 aa. Equivalent to Rv3443c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Probable rplM, 50S ribosomal protein L13, equivalent to P38014|RL13_MYCLE|RPLM|ML0364|B229_C3_232 from Mycobacterium leprae (147 aa), FASTA scores: opt: 917,E(): 7.5e-53, (91.15% identity in 147 aa overlap). Also highly similar to others e.g. Q53874|RL13_STRCO|RPLM|SC6G4.12 from Streptomyces coelicolor (147 aa), FASTA scores: opt: 668, E(): 1.1e-36,(65.5% identity in 145 aa overlap); Q9X1G5|RL13_THEMA|RPLM|TM1454 from Thermotoga maritima (149 aa), FASTA scores: opt: 536, E(): 4.4e-28, (53.65% identity in 136 aa overlap); O67722|RL13_AQUAE|RPLM|AQ_1877 from Aquifex aeolicus (144 aa), FASTA scores: opt: 529, E(): 1.2e-27, (53.2% identity in 141 aa overlap); etc. BELONGS TO THE L13P FAMILY OF RIBOSOMAL PROTEINS. X2BNH1,P66066 No NC_002945.3 Mycobrowser_v2 CDS 3810325 3810627 . - 0 Mb3474c esxT putative esat-6 like protein esxt Mb3474c, esxT, len: 100 aa. Equivalent to Rv3444c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). esxT, conserved hypothetical protein, equivalent to Q9CCV7|ML0363 POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (104 aa), FASTA scores: opt: 362, E(): 1.1e-18, (71.25% identity in 73 aa overlap). C-terminal part highly similar to Q49852|B229_C1_150 HYPOTHETICAL 5.3 KDA PROTEIN from Mycobacterium leprae (49 aa), FASTA scores: opt: 227, E(): 1.4e-09, (68.9% identity in 45 aa overlap). Q7TWH8 No NC_002945.3 Mycobrowser_v2 CDS 3810648 3810965 . - 0 Mb3475c esxU ESAT-6 like protein EsxU Mb3475c, len: 105 aa. Equivalent to Rv3445c len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). EsxU, ESAT-6 like protein (see citations below), showing weak similarity to O30373|VCD|PA2257 pyoverdine biosynthesis protein from Pseudomonas aeruginosa (215 aa), FASTA scores: opt: 103,E(): 5.6, (32.35% identity in 133 aa overlap). Seems to belong to the ESAT6 family. Start changed since first submission (-20 aa). X2BPM4 No cell wall and cell processes Rv3445c NC_002945.3 Mycobrowser_v2 CDS 3812229 3815939 . - 0 Mb3477c eccc4 esx conserved component eccc4. esx-4 type vii secretion system protein. probable membrane protein. Mb3477c, -, len: 1236 aa. Equivalent to Rv3447c,len: 1236 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1236 aa overlap). Probable conserved membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa),FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910,E(): 1.5e-44, (34.4% identity in 1319 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa), FASTA scores: opt: 805, E(): 1.9e-38, (25.85% identity in 1292 aa overlap); etc. The C-terminal region is similar to Q9CDD7|ML0052 (alias O33086|MLCB628.15c) HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 850,E(): 2.3e-41, (35.2% identity in 588 aa overlap); and O6973|Rv3871|MTV027.06 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (591 aa), FASTA scores: opt: 845, E(): 4.3e-41, (35.3% identity in 586 aa overlap). N-terminal part shows similarity with HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. O69735|Rv3870|MTV027.05 (747 aa), FASTA scores: opt: 761,E(): 3.6e-36, (38.2% identity in 746 aa overlap). Equivalent to AAK47893 from Mycobacterium tuberculosis strain CDC1551 (1200 aa) but longer 36 aa. Contains three of PS00017 ATP/GTP-binding site motif A (P-loop). Q7TWH5 No cell wall and cell processes Rv3447c NC_002945.3 Mycobrowser_v2 CDS 3818785 3820197 . - 0 Mb3480c eccb4 esx conserved component eccb4. esx-4 type vii secretion system protein. probable membrane protein. Mb3480c, -, len: 470 aa. Equivalent to Rv3450c,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 470 aa overlap). Probable conserved membrane protein (possible membrane spanning region near N-terminus). Similar to hypothetical unknowns proteins from Mycobacterium leprae e.g. O33088|MLCB628.17C|ML0054 HYPOTHETICAL 51.9 KDA PROTEIN (PUTATIVE MEMBRANE PROTEIN)(481 aa), FASTA scores: opt: 708, E(): 6.4e-32,(32.9% identity in 480 aa overlap); Q9CD29|ML2536 (552 aa), FASTA scores: opt: 394, E(): 1.7e-14, (33.6% identity in 503 aa overlap); etc. Also similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O69734|Rv3869|MTV027.04 (480 aa), FASTA scores: opt: 717, E(): 2e-32, (32.55% identity in 479 aa overlap); O05449|Rv3895c|MTCY15F10.17 (495 aa), FASTA scores: opt: 670, E(): 8.3e-30, (36.4% identity in 475 aa overlap); O5368|Rv0283|MTV035.11 (538 aa), FASTA scores: opt: 467, E(): 1.5e-18, (36.3% identity in 493 aa overlap); etc. Q7TWH2 No cell wall and cell processes Rv3450c NC_002945.3 Mycobrowser_v2 CDS 4067704 4069059 . + 0 Mb3714 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3714, -, len: 451 aa. Equivalent to Rv3689, len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 451 aa overlap). Probable conserved transmembrane protein, with Proline rich N-terminus,similar to Q9KYW6|SCE33.17 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (462 aa) FASTA scores: opt: 730, E(): 2.7e-21, (38.1% identity in 412 aa overlap). Q7TVX6 No cell wall and cell processes Rv3689 NC_002945.3 Mycobrowser_v2 CDS 3824590 3825132 . - 0 Mb3485c rplQ 50s ribosomal protein l17 rplq Mb3485c, rplQ, len: 180 aa. Equivalent to Rv3456c,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 180 aa overlap). Probable rplQ, 50S ribosomal protein L17, equivalent to Q9X797|RL17_MYCLE|ML1956|MLCB1222.26c 50S RIBOSOMAL PROTEIN L17 from Mycobacterium leprae (170 aa), FASTA scores: opt: 874, E(): 9.5e-45, (81.85% identity in 171 aa overlap). Also highly similar to other e.g. O86775|RL17_STRCO|SC6G4.08 from Streptomyces coelicolor (168 aa), FASTA scores: opt: 609, E(): 3.7e-29, (60.0% identity in 170 aa overlap); BAB47931|MLR0326 from Rhizobium loti (Mesorhizobium loti) (143 aa), FASTA scores: opt: 404, E(): 3.7e-17, (49.65% identity in 139 aa overlap); Q9Z9H5|RL17_THETH|RPLQ from Thermus aquaticus (subsp. thermophilus) (118 aa), FASTA scores: opt: 366,E(): 5.5e-15, (53.15% identity in 111 aa overlap); P02416|RL17_ECOLI|RPLQ|B3294 from Escherichia coli strain K12 (127 aa), FASTA scores: opt: 347, E(): 7.6e-14, (50.4% identity in 119 aa overlap); etc. BELONGS TO THE L17P FAMILY OF RIBOSOMAL PROTEINS. X2BPN0,P0A5V5 No NC_002945.3 Mycobrowser_v2 CDS 3820318 3821106 . + 0 Mb3481 cut3 PROBABLE CUTINASE PRECURSOR CUT3 Mb3481, cut3, len: 262 aa. Equivalent to Rv3451,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Probable cut3,cutinase precursor (EC 3.1.1.-), similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214,E(): 2e-05, (31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203, E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. the downstream ORF O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN (226 aa), FASTA scores: opt: 775, E(): 1e-37, (58.65% identity in 220 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 565, E(): 1.3e-25, (44.85% identity in 223 aa overlap); Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 489, E(): 3e-21, (47.05% identity in 221 aa overlap); etc. Equivalent to AAK47897 from Mycobacterium tuberculosis strain CDC1551 (247 aa) but longer 15 aa. Contains cutinase, serine active site motif (PS00155). BELONGS TO THE CUTINASE FAMILY. Alternative start possible at 3733. Start changed since first submission (+15 aa). X2BNC9,P0A537 No cell wall and cell processes Rv3451 NC_002945.3 Mycobrowser_v2 CDS 3832671 3833765 . - 0 Mb3497c rmlB2 possible dtdp-glucose 4,6-dehydratase Mb3497c, rmlB2, len: 364 aa. Equivalent to Rv3468c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 364 aa overlap). Possible rmlB2 (alternate gene name: rfbB), DTDP-glucose-4,6-dehydratase (EC 4.2.1.46), similar to others e.g. O08246|MTME from Streptomyces argillaceus (331 aa), FASTA scores: opt: 238,E(): 1.2e-07, (29.65% identity in 344 aa overlap); Q9LFG7|F4P12_220 from Arabidopsis thaliana (Mouse-ear cress) (433 aa), FASTA scores: opt: 237, E(): 1.8e-07,(27.25% identity in 308 aa overlap); Q9LZI2|F26K9_260 from Arabidopsis thaliana (Mouse-ear cress) (445 aa), FASTA scores: opt: 225, E(): 1e-06, (25.95% identity in 335 aa overlap); etc. Also similar to various enzymes and hypothetical unknowns proteins e.g. BAB48655|MLL1234 UDP-GLUCOSE 4-EPIMERASE from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 757, E(): 4.6e-40,(43.4% identity in 302 aa overlap). First start taken,alternative at 17080 in cSCYY13E12 suggested by similarity. Note that previously known as rmlB3. Q7TWG3 No NC_002945.3 Mycobrowser_v2 CDS 3822105 3823790 . + 0 Mb3483 probable conserved integral membrane protein Mb3483, -, len: 561 aa. Equivalent to Rv3453 and Rv3454, len: 110 aa and 422 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 107 aa overlap and 99.8% identity in 422 aa overlap). Rv3453: Possible conserved transmembrane protein, showing weak similarity with other proteins e.g. Q9F6C3 PUTATIVE ABC TRANSPORTER from Propionibacterium thoenii (424 aa), FASTA scores: opt: 104, E(): 6.8, (40.6% identity in 69 aa overlap). Rv3454: Probable conserved integral membrane protein, showing some similarity to various proteins (generally transporters) e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 145, E(): 0.13, (28.2% identity in 188 aa overlap); Q01266|YHYC_PSESN HYPOTHETICAL PROTEIN IN HYUC 3'REGION (ORF 5) (FRAGMENT) from Pseudomonas sp. strain NS671 (245 aa), FASTA scores: opt: 130, E(): 0.75, (24.65% identity in 134 aa overlap); Q9I242|PA2073 PROBABLE TRANSPORTER (MEMBRANE SUBUNIT) from Pseudomonas aeruginosa (476 aa), FASTA scores: opt: 125, E(): 2.5, (24.6% identity in 252 aa overlap); etc. Equivalent to AAK47900 from Mycobacterium tuberculosis strain CDC1551 (562 aa) but shorter 140 aa. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) results in a single product that is more similar to Rv3454. Q7TWH0 No cell wall and cell processes Rv3453 NC_002945.3 Mycobrowser_v2 CDS 3823752 3824522 . - 0 Mb3484c truA PROBABLE TRNA PSEUDOURIDINE SYNTHASE A TRUA (PSEUDOURIDYLATE SYNTHASE I) (PSEUDOURIDINE SYNTHASE I) (URACIL HYDROLYASE) Mb3484c, truA, len: 256 aa. Equivalent to Rv3455c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable truA,pseudouridine synthase A (EC 4.2.1.70), equivalent to Q9X796|TRUA_MYCLE|ML1955|MLCB1222.25c TRNA PSEUDOURIDINE SYNTHASE A from Mycobacterium leprae (249 aa), FASTA scores: opt: 1345, E(): 3.2e-80, (77.25% identity in 246 aa overlap). Also highly similar to others e.g. O86776|TRUA_STRCO|SC6G4.09 from Streptomyces coelicolor (284 aa), FASTA scores: opt: 595, E(): 1.7e-31, (49.8% identity in 259 aa overlap); Q9RS37|DR2290 from Deinococcus radiodurans (280 aa), FASTA scores: opt: 383,E(): 1e-17, (41.2% identity in 216 aa overlap); Q9PJT0|TRUA_CHLMU|TC0748 from Chlamydia muridarum (267 aa), FASTA scores: opt: 334, E(): 1.5e-14, (37.65% identity in 231 aa overlap); P07649|TRUA_ECOLI|HIST|ASUC|LEUK|B2318 from Escherichia coli strain K12 (270 aa), FASTA scores: opt: 315, E(): 2.5e-13, (33.35% identity in 240 aa overlap); etc. BELONGS TO THE TRUA FAMILY OF PSEUDOURIDINE SYNTHASES. X2BP35,P65847 No NC_002945.3 Mycobrowser_v2 CDS 3825164 3826207 . - 0 Mb3486c rpoA PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE ALPHA SUBUNIT) (DNA-DIRECTED RNA NUCLEOTIDYLTRANSFERASE) Mb3486c, rpoA, len: 347 aa. Equivalent to Rv3457c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Probable rpoA, alpha chain of RNA polymerase (EC 2.7.7.6), equivalent to Q9X798|RPOA_MYCLE|ML1957|MLCB1222.27c DNA-DIRECTED RNA POLYMERASE ALPHA from Mycobacterium leprae (347 aa), FASTA scores: opt: 2139, E(): 1.3e-123, (95.65% identity in 347 aa overlap). Also highly similar to others e.g. P72404|RPOA_STRCO|C6G4.07 from Streptomyces coelicolor (340 aa), FASTA scores: opt: 1672, E(): 4.7e-95, (75.55% identity in 348 aa overlap); Q9X4V6|RPOA_STRGT from Streptomyces granaticolor (340 aa), FASTA scores: opt: 1671, E(): 5.4e-95, (75.55% identity in 348 aa overlap); P20429|RPOA_BACSU from Bacillus subtilis (314 aa), FASTA scores: opt: 939, E(): 3e-50, (48.9% identity in 311 aa overlap); etc. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE RNA POLYMERASE ALPHA CHAIN FAMILY. X2BND1,P66702 No NC_002945.3 Mycobrowser_v2 CDS 3826355 3826960 . - 0 Mb3487c rpsD 30s ribosomal protein s4 rpsd Mb3487c, rpsD, len: 201 aa. Equivalent to Rv3458c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable rpsD, 30S ribosomal protein S4, equivalent to Q9X799|RS4_MYCLE|RPSD|ML1958|MLCB1222.28c 30S RIBOSOMAL PROTEIN S4 from Mycobacterium leprae (201 aa), FASTA scores: opt: 1271, E(): 2.2e-73, (93.5% identity in 201 aa overlap); and P45811|RS4_MYCBO|RPSD from Mycobacterium bovis (131 aa), FASTA scores: opt: 867, E(): 4.9e-48,(100.0% identity in 130 aa overlap). Also highly similar to others e.g. P81288|RS4_BACST|RPSD from Bacillus stearothermophilus (198 aa), FASTA scores: opt: 665, E(): 4e-35, (52.25% identity in 201 aa overlap); Q9K7Z8|RPSD|BH3209 from Bacillus halodurans (200 aa),FASTA scores: opt: 626, E(): 1.2e-32, (48.75% identity in 203 aa overlap); Q9X1I3|RS4_THEMA|RPSD|TM1473 from Thermotoga maritima (209 aa), FASTA scores: opt: 591, E(): 2e-30, (45.0% identity in 209 aa overlap); etc. Contains ribosomal protein S4 signature (PS00632) and ATP/GTP binding site motif (PS00017). BELONGS TO THE S4P FAMILY OF RIBOSOMAL PROTEINS. X2BNV6,P45811 No NC_002945.3 Mycobrowser_v2 CDS 3826969 3827388 . - 0 Mb3488c rpsK 30s ribosomal protein s11 rpsk Mb3488c, rpsK, len: 139 aa. Equivalent to Rv3459c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 139 aa overlap). Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867,E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS. X2BNI4,P45812 No NC_002945.3 Mycobrowser_v2 CDS 3827392 3827766 . - 0 Mb3489c rpsM 30s ribosomal protein s13 rpsm Mb3489c, rpsM, len: 124 aa. Equivalent to Rv3460c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Probable rpsM, 30S ribosomal protein S13, equivalent to Q9X7A1|RS13_MYCLE|RPSM|ML1960|MLCB1222.30c 30S RIBOSOMAL PROTEIN S13 from Mycobacterium leprae (124 aa), FASTA scores: opt: 762, E(): 1.5e-43, (92.75% identity in 124 aa overlap); and P45813|RS13_MYCBO|RPSM from Mycobacterium bovis (123 aa), FASTA scores: opt: 727, E(): 3e-41,(98.25% identity in 114 aa overlap). Also highly similar to others e.g. O86773|RS13_STRCO|SC6G4.05 from Streptomyces coelicolor (126 aa), FASTA scores: opt: 631,E(): 6.2e-35, (73.75% identity in 122 aa overlap); Q9RA65|RPS13 from Thermus aquaticus (subsp. thermophilus) (126 aa), FASTA scores: opt: 552, E(): 9.8e-30, (62.6% identity in 123 aa overlap); P20282|RS13_BACSU|RPSM from Bacillus subtilis (120 aa), FASTA scores: opt: 533, E(): 1.7e-28, (64245% identity in 121 aa overlap); etc. Contains ribosomal protein S13 signature (PS00646). BELONGS TO THE S13P FAMILY OF RIBOSOMAL PROTEINS. X2BP39,P45813 No NC_002945.3 Mycobrowser_v2 CDS 3883854 3889670 . + 0 Mb3541 PE_PGRS55 pe-pgrs family protein pe_pgrs56 Mb3541, PE_PGRS55, len: 1938 aa. Equivalent to Rv3511 and Rv3512, len: 714 aa and 1079 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 706 aa overlap and 96.0% identity in 1117 aa overlap). Rv3511: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 2563, E(): 1.5e-94, (59.65% identity in 773 aa overlap); and upstream O53553|Rv3508|MTV023.15 (1901 aa),FASTA scores: opt: 2455, E(): 3.9e-90, (60.4% identity in 737 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. Rv3512: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 3688, E(): 4.5e-130, (53.95% identity in 1136 aa overlap); and downstream O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 3611, E(): 3.6e-127, (53.15% identity in 1195 aa overlap); etc. Frameshifted PGRS protein, could be continuation of upstream MTV023.18, but no error could be found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344 bp insertion results in a single product which is more similar to PE_PGRS55. There are also 3 additional in-frame insertions of 9 bp each (*-accggcgga, *-cggcaacgg and *-cggcggtac) and 2 substitutions compared to the homolog in Mycobacterium tuberculosis strain H37Rv. Q7TWC0 No NC_002945.3 Mycobrowser_v2 CDS 3827982 3828095 . - 0 Mb3490c rpmJ 50s ribosomal protein l36 rpmj Mb3490c, rpmJ, len: 37 aa. Equivalent to Rv3461c,len: 37 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 37 aa overlap). Probable rpmJ, 50S ribosomal protein L36, equivalent to P45810|RL36_MYCBO|RPMJ from Mycobacterium bovis (37 aa); and Q9X7A2|RL36_MYCLE|RPMJ|ML1961|MLCB1222.31c 50S RIBOSOMAL PROTEIN L36 from Mycobacterium leprae (37 aa),FASTA scores: opt: 241, E(): 9.7e-14, (86.5% identity in 37 aa overlap). Also highly similar to others e.g. O86772|RL36_STRCO|SC6G4.04 from Streptomyces coelicolor (37 aa), FASTA scores: opt: 233, E(): 4.5e-13, (83.8% identity in 37 aa overlap); P07841|RL36_BACST|RPMJ from Bacillus stearothermophilus (37 aa), FASTA scores: opt: 214, E(): 1.6e-11, (72.95% identity in 37 aa overlap); P12230|RK36_SPIOL|RPL36 from Spinacia oleracea (Spinach) (37 aa), FASTA scores: opt: 211, E(): 2.9e-11, (70.25% identity in 37 aa overlap); etc. Contains PS00828 Ribosomal protein L36 signature. BELONGS TO THE L36P FAMILY OF RIBOSOMAL PROTEINS. X2BPN4,P0A5W7 No NC_002945.3 Mycobrowser_v2 CDS 4069086 4069739 . + 0 Mb3715 PROBABLE CONSERVED MEMBRANE PROTEIN Mb3715, -, len: 217 aa. Equivalent to Rv3690, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Probable conserved membrane protein, similar to Q9KYW5|SCE33.18 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (231 aa), FASTA scores: opt: 419, E(): 1.5e-19, (36.0% identity in 211 aa overlap). Equivalent to AAK48159 from Mycobacterium tuberculosis strain CDC1551 (233 aa) but shorter 16 aa. Q7TVX5 No cell wall and cell processes Rv3690 NC_002945.3 Mycobrowser_v2 CDS 3828128 3828349 . - 0 Mb3491c infA PROBABLE TRANSLATION INITIATION FACTOR IF-1 INFA Mb3491c, infA, len: 73 aa. Equivalent to Rv3462c,len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Probable infA,initiation factor IF-1, equivalent to P45957|ML1962|INFA TRANSLATION INITIATION FACTOR IF-1 from Mycobacterium bovis (72 aa) and Mycobacterium leprae (72 aa), FASTA scores: opt: 472, E(): 6.6e-28, (100.0% identity in 72 aa overlap). Also highly similar to others e.g. O54209|IF1_STRCO|INFA|SC6G4.03 from Streptomyces coelicolor (73 aa), FASTA scores: opt: 424, E(): 2e-24,(84.95% identity in 73 aa overlap); O50630|IF1_BACHD|INFA|BH0158 from Bacillus halodurans (71 aa), FASTA scores: opt: 388, E(): 8.1e-22, (77.8% identity in 72 aa overlap); Q9XD14|IF1_LEPIN|INFA from Leptospira interrogans (71 aa), FASTA scores: opt: 376, E(): 6e-21,(80.0% identity in 70 aa overlap); etc. CONTAINS 1 'S1 MOTIF' DOMAIN. BELONGS TO THE IF-1 FAMILY. X2BND6,P0A5H6 No NC_002945.3 Mycobrowser_v2 CDS 3828603 3829460 . + 0 Mb3492 conserved protein Mb3492, -, len: 285 aa. Equivalent to Rv3463, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 285 aa overlap). Conserved hypothetical protein, similar to Q9RDA2|SCE20.23 HYPOTHETICAL 31.4 KDA PROTEIN from Streptomyces coelicolor (290 aa), FASTA scores: opt: 770, E(): 2.2e-41, (48.6% identity in 247 aa overlap); and Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (341 aa), (see BLASTP results), FASTA scores: opt: 119, E(): 2.9, (24.1% identity in 274 aa overlap). Q7TWG8 No conserved hypotheticals Rv3463 NC_002945.3 Mycobrowser_v2 CDS 3856088 3856570 . - 0 Mb3522c CONSERVED HYPOTHETICAL MCE ASSOCIATED PROTEIN Mb3522c, -, len: 160 aa. Equivalent to Rv3492c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Q7TWD9 No conserved hypotheticals Rv3492c NC_002945.3 Mycobrowser_v2 CDS 3829533 3830528 . + 0 Mb3493 rmlB1 dtdp-glucose 4,6-dehydratase rmlb Mb3493, rmlB1, len: 331 aa. Equivalent to Rv3464,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 331 aa overlap). Probable rmlB1 (alternate gene name: rfbB), DTDP-glucose-4,6-dehydratase (EC 4.2.1.46), nearly identical to Q50556|RMLB rhamnose biosynthesis protein (EC 4.2.1.46) from Mycobacterium tuberculosis (329 aa) (previously rfbB, now known as rmlB). Equivalent to Q9CBH7|RMLB|ML1964 DTDP-GLUCOSE 4,6-DEHYDRATASE (alias Q9X7A3|RMLB PUTATIVE DTDP-(GLUCOSE OR RHAMNOSE)-4,6-DEHYDRATASE (331 aa)) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1925, E(): 1.9e-112,(84.0% identity in 331 aa overlap). Also highly similar to others e.g. Q9UZH2|RFBB|PAB0785 from Pyrococcus abyssi (333 aa), FASTA scores: opt: 1115, E(): 4.2e-62, (51.55% identity in 322 aa overlap); O27817|MTH1789 from Methanobacterium thermoautotrophicum (336 aa), FASTA scores: opt: 1104, E(): 2.1e-61, (51.65% identity in 331 aa overlap); BAB60064|TVG0950610 from Thermoplasma volcanium (318 aa), FASTA scores: opt: 1102, E(): 2.6e-61,(49.65% identity in 310 aa overlap); etc. Also related to P72050|MTCY13D12.18|RV3784 HYPOTHETICAL 36.3 KDA PROTEIN (SIMILAR TO GALACTOWALDENASES FROM EUKARYOTIC AND PROKARYOTIC ORIGIN) from Mycobacterium tuberculosis (326 aa), FASTA scores: E(): 1.4e-26, (33.8% identity in 320 aa overlap). Q7TWG7 No NC_002945.3 Mycobrowser_v2 CDS 3830530 3831138 . + 0 Mb3494 rmlC dtdp-4-dehydrorhamnose 3,5-epimerase rmlc (dtdp-4-keto-6-deoxyglucose 3,5-epimerase) (dtdp-l-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase) Mb3494, rmlC, len: 202 aa. Equivalent to Rv3465,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Probable rmlC (alternate gene name: rfbC), dtdp-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13), nearly identical to O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis (203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5% identity in 200 aa overlap) (previously known as rfbC). Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64,(75.4% identity in 199 aa overlap). Also highly similar to others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis (198 aa), FASTA scores: opt: 671, E(): 7e-38, (51.3% identity in 193 aa overlap); Q9L6C5 from Streptomyces antibioticus (202 aa), FASTA scores: opt: 665, E(): 1.8e-37, (49.25% identity in 197 aa overlap); P29783|STRM_STRGR from Streptomyces griseus (200 aa),FASTA scores: opt: 608, E(): 1.2e-33, (49.25% identity in 201 aa overlap); Q54265|STRM from Streptomyces glaucescens (200 aa), FASTA scores: opt: 603, E(): 2.5e-33, (46.7% identity in 197 aa overlap); etc. Also highly similar to Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE 3-EPIMERASE from Streptomyces fradiae (205 aa), FASTA scores: opt: 625,E(): 8.6e-35, (45.9% identity in 194 aa overlap). Q7TWG6 No intermediary metabolism and respiration Rv3465 NC_002945.3 Mycobrowser_v2 CDS 3834840 3836498 . - 0 Mb3499c ilvB2 PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB2 (AHAS) (ACETOHYDROXY-ACID SYNTHASE LARGE SUBUNIT) (ALS) Mb3499c, ilvB2, len: 552 aa. Equivalent to Rv3470c,len: 552 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 552 aa overlap). Probable ilvB2,acetolactate synthase large subunit (EC 4.1.3.18), similar to others e.g. P73913|ILVG|SLR2088 from Synechocystis sp. strain PCC 6803 (621 aa), FASTA scores: opt: 779, E(): 4.5e-39, (30.7% identity in 567 aa overlap); O78518|ILVB_GUITH from Guillardia theta (Cryptomonas phi) (575 aa), FASTA scores: opt: 742, E(): 6.9e-37, (28.8% identity in 566 aa overlap); Q59950|ILVX from Spirulina platensis (612 aa), FASTA scores: opt: 715, E(): 3e-35,(28.45% identity in 569 aa overlap); etc. Contains thiamine pyrophosphate enzymes signature (PS00187). Q7TWG1 No NC_002945.3 Mycobrowser_v2 CDS 3836504 3837037 . - 0 Mb3500c CONSERVED HYPOTHETICAL PROTEIN Mb3500c, -, len: 177 aa. Equivalent to Rv3471c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 177 aa overlap). Conserved hypothetical protein, similar to Q59013|MJ1618 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (125 aa), FASTA scores: opt: 262, E(): 1.2e-09, (39.05% identity in 105 aa overlap); and O26452|MTH352 CONSERVED PROTEIN from Methanobacterium thermoautotrophicum (131 aa), FASTA scores: opt: 222, E(): 3.8e-07, (35.05% identity in 117 aa overlap). Equivalent to AAK47934 from Mycobacterium tuberculosis strain CDC1551 (184 aa) but shorter 7 aa. Q7TWG0 No conserved hypotheticals Rv3471c NC_002945.3 Mycobrowser_v2 CDS 3837058 3837564 . + 0 Mb3501 conserved protein Mb3501, -, len: 168 aa. Equivalent to Rv3472, len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins e.g. Q9ZAT9|DPSH DAUNORUBICIN BIOSYNTHESIS ENZYME from Streptomyces peucetius (194 aa), FASTA scores: opt: 181, E(): 6.8e-05, (30.7% identity in 127 aa overlap); Q53879 DAUH/E from Streptomyces sp. C5 (151 aa), FASTA scores: opt: 168, E(): 0.00038, (29.25% identity in 127 aa overlap); and Q9L4U3|AKNV from Streptomyces galilaeus (144 aa), FASTA scores: opt: 122, E(): 0.36, (31.25% identity in 129 aa overlap). Q7TWF9 No conserved hypotheticals Rv3472 NC_002945.3 Mycobrowser_v2 CDS 3837644 3838429 . - 0 Mb3502c bpoA POSSIBLE PEROXIDASE BPOA (NON-HAEM PEROXIDASE) Mb3502c, bpoA, len: 261 aa. Equivalent to Rv3473c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Possible bpoA,peroxidase (non-haem peroxidase) (EC 1.11.1.-), similar to various enzymes or hypothetical unknown proteins e.g. O85849 HYPOTHETICAL 26.2 KDA PROTEIN from Sphingomonas aromaticivorans (247 aa), FASTA scores: opt: 684, E(): 4.9e-34, (43.8% identity in 242 aa overlap); AAK45412|MT1155 HYDROLASE, ALPHA/BETA HYDROLASE FOLD FAMILY from Mycobacterium tuberculosis strain CDC1551 (311 aa), FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa overlap); Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from Streptomyces coelicolor (352 aa), FASTA scores: opt: 248, E(): 9.7e-08, (26.05% identity in 261 aa overlap); P29715|BPA2_STRAU|BPOA2 NON-HAEM BROMOPEROXIDASE (EC 1.11.1.-) (BROMIDE PEROXIDASE) (277 aa), FASTA scores: opt: 237, E(): 3.6e-07, (29.45% identity in 265 aa overlap); O31168|PRXC_STRAU|CPO|CPOT NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (278 aa), FASTA scores: opt: 236, E(): 4.2e-07, (29.45% identity in 265 aa overlap); AAK62388|T5L19.180 LIPASE-LIKE PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (350 aa), FASTA scores: opt: 236, E(): 5.1e-07, (26.65% identity in 274 aa overlap); etc. Also similar to O06575|BPOB|Rv1123c|MTCY22G8.12c HYPOTHETICAL 32.5 KDA PROTEIN from Mycobacterium tuberculosis (302 aa), FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa overlap). Equivalent to AAK47936 from Mycobacterium tuberculosis strain CDC1551 (294 aa) but shorter 33 aa. May have been inactivated or truncated by neighbouring IS6110. Q7TWF8 No NC_002945.3 Mycobrowser_v2 CDS 3838709 3840058 . - 0 Mb3503c kgtP PROBABLE DICARBOXYLIC ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN KGTP (DICARBOXYLATE TRANSPORTER) Mb3503c, kgtP, len: 449 aa. Equivalent to Rv3476c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 449 aa overlap). Probable kgtP,dicarboxylate-transport integral membrane protein,possibly member of major facilitator superfamily (MFS),highly similar to others e.g. Q9HT43|PA5530 from Pseudomonas aeruginosa (435 aa), FASTA scores: opt: 1209,E(): 2.3e-68, (47.05% identity in 425 aa overlap); Q9I6Q9|PCAT|PA0229 from Pseudomonas aeruginosa (432 aa),FASTA scores: opt: 1131, E(): 1.8e-63, (40.4% identity in 438 aa overlap); Q9WWZ2 from Pseudomonas putida (429 aa),FASTA scores: opt: 1090, E(): 6.5e-61, (41.2% identity in 425 aa overlap); P17448|KGTP_ECOLI|WITA|B2587 from Escherichia coli strain K12 (432 aa), FASTA scores: opt: 1083, E(): 1.8e-60, (40.05% identity in 422 aa overlap); etc. Also similar to O05301|MTCI364.12|Rv1200 HYPOTHETICAL 44.6 KDA PROTEIN from Mycobacterium tuberculosis (425 aa),FASTA scores: E(): 5.2e-25, (28.5% identity in 382 aa overlap). Contains sugar transport protein signatures 1 and 2 (PS00216, PS00217). BELONG TO THE SUGAR TRANSPORTER FAMILY. Q7TWF7 No NC_002945.3 Mycobrowser_v2 CDS 3840764 3841945 . + 0 Mb3505 PPE60 pe family protein ppe60 Mb3505, PPE60, len: 393 aa. Equivalent to Rv3478,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). PPE60 (alternate gene name: mtb39c). Member of the M. tuberculosis PPE family,highly similar to others e.g. Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa),FASTA scores: opt: 2165, E(): 1.1e-109, (85.35% identity in 396 aa overlap); MTCI364.08; MTCY10G2.10; MTCY03A2.22c; MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc. Note that expression of Rv3478 was demonstrated in lysates by immunodetection (see citation below). Q7TWF5 No NC_002945.3 Mycobrowser_v2 CDS 3842158 3843459 . + 0 Mb3507 HYPOTHETICAL PROTEIN [FIRST PART] Mb3507, -, len: 433 aa. Equivalent to 5' end of Rv3479, len: 1075 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 418 aa overlap). Possible transmembrane protein, with hydrophobic stretches at C-terminus. Start changed since first submission (-54 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, a 713 bp deletion splits Rv3479 into 2 parts, Mb3507 and Mb3508. Q7TWF4 No NC_002945.3 Mycobrowser_v2 CDS 3843464 3844510 . + 0 Mb3508 HYPOTHETICAL TRANSMEMBRANE PROTEIN [SECOND PART] Mb3508, -, len: 348 aa. Equivalent to 3' end of Rv3479, len: 1075 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 348 aa overlap). Possible transmembrane protein, with hydrophobic stretches at C-terminus. Start changed since first submission (-54 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, a 713 bp deletion splits Rv3479 into 2 parts, Mb3507 and Mb3508. Q7TWF3 No NC_002945.3 Mycobrowser_v2 CDS 3844534 3845358 . - 0 Mb3509c CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb3509c, -, len: 274 aa. Equivalent to 3' end of Rv3480c, len: 497 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 274 aa overlap). Conserved hypothetical protein, similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa),FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). SEEMS TO BELONG TO THE UPF0089 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3480c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Q7TWF2 No NC_002945.3 Mycobrowser_v2 CDS 3845372 3846025 . - 0 Mb3510c CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb3510c, -, len: 217 aa. Equivalent to 5' end of Rv3480c, len: 497 aa, from Mycobacterium tuberculosis strain H37Rv, (98.6% identity in 216 aa overlap). Conserved hypothetical protein, similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa),FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). SEEMS TO BELONG TO THE UPF0089 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3480c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Q7TWF1 No NC_002945.3 Mycobrowser_v2 CDS 3846947 3847729 . - 0 Mb3512c PROBABLE CONSERVED MEMBRANE PROTEIN Mb3512c, -, len: 260 aa. Equivalent to Rv3482c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Probable conserved membrane protein. N-terminal region shares some similarity with N-terminus of O88067|SCI35.32c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (319 aa), FASTA scores: opt: 155, E(): 0.023, (54.55% identity in 33 aa overlap); and with C-terminus of O06254|Rv3437|MTCY77.09 HYPOTHETICAL 17.9 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (alias AAK47883|MT3542.1 from strain CDC1551) (158 aa), FASTA scores: opt: 140, E(): 0.11, (58.8% identity in 34 aa overlap). Some similarity to others e.g. Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (347 aa), FASTA scores: opt: 131, E(): 0.75, (29.4% identity in 221 aa overlap). First start taken. Q7TWE9 No cell wall and cell processes Rv3482c NC_002945.3 Mycobrowser_v2 CDS 4047130 4047828 . - 0 Mb3692c possible protease Mb3692c, -, len: 232 aa. Equivalent to Rv3668c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 232 aa overlap). Possible protease (EC 3.4.-.-) (and more specifically a putative alkaline serine protease (EC 3.4.21.-), equivalent to Q9CB98|ML2295 HYPOTHETICAL PROTEIN from Mycobacterium leprae (234 aa),FASTA scores: opt: 1249, E(): 7.4e-66, (77.5% identity in 231 aa overlap). Also similar at C-terminal end with many proteases e.g. O86984 ALKALINE SERINE PROTEASE PRECURSOR from Thermomonospora fusca (368 aa), FASTA scores: opt: 190, E(): 0.00056, (28.9% identity in 173 aa overlap); Q55353|SAPII ALKALINE SERINE PROTEASE II from Streptomyces sp (382 aa), FASTA scores: opt: 160, E(): 0.032, (27.15% identity in 199 aa overlap); O54109|SC10A5.18 PUTATIVE SECRETED PROTEASE from Streptomyces coelicolor (411 aa),FASTA scores: opt: 155, E(): 0.066, (26.4% identity in 163 aa overlap); Q54392|SAL|SCI11.35C SERINE PROTEASE SAL PRECURSOR (300 aa), FASTA scores: opt: 153, E(): 0.068,(28.1% identity in 185 aa overlap); P00778|PRLA_LYSEN|ALPHA-LP ALPHA-LYTIC PROTEASE PRECURSOR (397 aa), FASTA scores: opt: 154, E(): 0.074, (26.75% identity in 172 aa overlap); etc. Also similar with Q50618|YI15_MYCTU|Rv1815|MT1863|MTCY1A11.28c HYPOTHETICAL 22.8 KDA PROTEIN from Mycobacterium tuberculosis (221 aa),FASTA scores: opt: 134, E(): 0.69, (30.95% identity in 181 aa overlap). Q7TVZ6 No intermediary metabolism and respiration Rv3668c NC_002945.3 Mycobrowser_v2 CDS 3847773 3848435 . - 0 Mb3513c possible exported protein Mb3513c, -, len: 220 aa. Equivalent to Rv3483c,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Conserved hypothetical protein, similar to Q9CC94|ML1099 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (202 aa), FASTA scores: opt: 276, E(): 1.4e-08, (33.1% identity in 148 aa overlap). Also showing similarity with Mycobacterium tuberculosis proteins Q11065|LPRE_MYCTU|LPRE|Rv1252c|MT1291|MTCY50.30. PUTATIVE LIPOPROTEIN PRECURSOR (202 aa), FASTA scores: opt: 276,E(): 1.4e-08, (29.5% identity in 200 aa overlap); O53445|Rv1097c|MTV017.50c HYPOTHETICAL 29.9 KDA PROTEIN (293 aa), FASTA scores: opt: 161, E(): 0.047, (25.4% identity in 118 aa overlap); P71882|LPPP_MYCTU|Rv2330c|MT2392|MTCY3G12.04 PUTATIVE LIPOPROTEIN PRECURSOR (175 aa), FASTA scores: opt: 146,E(): 0.21, (28.25% identity in 184 aa overlap); and O06170|Rv2507|MTCY07A7.13 HYPOTHETICAL 28.5 KDA PROTEIN (273 aa), FASTA scores: opt: 148, E(): 0.23, (25.15% identity in 191 aa overlap). Q7TWE8 No cell wall and cell processes Rv3483c NC_002945.3 Mycobrowser_v2 CDS 3860154 3861509 . - 0 Mb3526c mce4D MCE-FAMILY PROTEIN MCE4D Mb3526c, mce4D, len: 451 aa. Equivalent to Rv3496c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (531 aa), FASTA scores: opt: 837, E(): 2.6e-34, (34.55% identity in 446 aa overlap); Q9F359|SC8A2.04c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (337 aa), FASTA scores: opt: 606,E(): 4.9e-23, (32.35% identity in 300 aa overlap); etc. Hydrophobic region at N-terminus. Q7TWD5 No NC_002945.3 Mycobrowser_v2 CDS 3909099 3910253 . - 0 Mb3559c CONSERVED HYPOTHETICAL PROTEIN Mb3559c, -, len: 384 aa. Equivalent to Rv3529c,len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 384 aa overlap). Conserved hypothetical protein, showing some similarity to Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 HYPOTHETICAL 46.1 KDA PROTEIN from Mycobacterium tuberculosis (388 aa) FASTA scores: opt: 261, E(): 1.6e-09, (27.25% identity in 253 aa overlap). Q7TWA2 No conserved hypotheticals Rv3529c NC_002945.3 Mycobrowser_v2 CDS 3848701 3850239 . + 0 Mb3514 cpsA POSSIBLE CONSERVED PROTEIN CPSA Mb3514, cpsA, len: 512 aa. Equivalent to Rv3484,len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Possible cpsA,hypothetical protein, equivalent to Q50160|CPSA|ML2247 HYPOTHETICAL PROTEIN CPSA from Mycobacterium leprae (516 aa), FASTA scores: opt: 2557, E(): 1.6e-143, (74.9% identity in 518 aa overlap); and with good similarity to Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FASTA scores: opt: 855, E(): 4.6e-43,(34.45% identity in 502 aa overlap). Also similar (or with similarity) to hypothetical proteins from Mycobacterium tuberculosis: P96872|Rv3267|MTCY71.07 (498 aa), FASTA scores: opt: 928, E(): 2.3e-47, (37.35% identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c (684 aa), FASTA scores: opt: 425, E(): 1.5e-17, (26.15% identity in 524 aa overlap). Shows also similarity with various bacterial proteins e.g. Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (507 aa), FASTA scores: opt: 329, E(): 5.3e-12, (28.85% identity in 478 aa overlap); Q9K4E6|2SC6G5.02 CONSERVED HYPOTHETICAL PROTEIN,POSSIBLE MEMBRANE PROTEIN, from Streptomyces coelicolor (382 aa), FASTA scores: opt: 305, E(): 1.1e-10, (29.8% identity in 386 aa overlap); O69850|SC1C3.08c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (366 aa), FASTA scores: opt: 304, E(): 1.2e-10, (29.6% identity in 395 aa overlap); Q9KZK3|SCE34.23 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (396 aa), FASTA scores: opt: 296, E(): 3.8e-10, (31.25% identity in 349 aa overlap); AAK43602|CPSA CPSA PROTEIN from Streptococcus agalactiae (485 aa), FASTA scores: opt: 250, E(): 2.4e-07, (30.25% identity in 162 aa overlap); etc. Q7TWE7 No conserved hypotheticals Rv3484 NC_002945.3 Mycobrowser_v2 CDS 3850245 3851189 . - 0 Mb3515c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb3515c, -, len: 314 aa. Equivalent to Rv3485c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar, but longer 41 aa, to P71824|Rv0769|MTCY369.14 PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE CY369.14 from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.0% identity in 253 aa overlap). Also similar to various dehydrogenases e.g. P25529|HDHA_ECOLI|HSDH|B1619 NAD-DEPENDENT 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE (SDR FAMILY) (EC 1.1.1.159) from Escherichia coli strain K12 (alias BAB35750|ECS2327 or AAG56608|HDHA for strain O157:H7) (255 aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.7% identity in 248 aa overlap); Q9FD15|RUBG PUTATIVE REDUCTASE (SDR FAMILY) from Streptomyces collinus (249 aa), FASTA scores: opt: 446, E(): 1.5e-18, (36.1% identity in 255 aa overlap); BAB51974|MLL5540 PUTATIVE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (253 aa), FASTA scores: opt: 442, E(): 2.5e-18, (36.25% identity in 251 aa overlap); Q08632|SDR1_PICAB SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (SDR FAMILY) from Picea abies (Norway spruce) (Picea excelsa) (271 aa), FASTA scores: opt: 441, E(): 3.1e-18, (32.3% identity in 260 aa overlap); Q9A326|CC3380 2-DEOXY-D-GLUCONATE 3-DEHYDROGENASE from Caulobacter crescentus (260 aa),FASTA scores: opt: 436, E(): 5.7e-18, (32.8% identity in 253 aa overlap); Q16698|DECR_HUMAN 2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.3.1.34) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 430, E(): 1.5e-17, (30.4% identity in 306 aa overlap); etc. Contains short-chain alcohol dehydrogenase family signature (PS00061). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (SDR). Q7TWE6 No intermediary metabolism and respiration Rv3485c NC_002945.3 Mycobrowser_v2 CDS 3921274 3922713 . + 0 Mb3569 PPE63 ppe family protein ppe63 Mb3569, PPE63, len: 479 aa. Equivalent to Rv3539,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Member of the Mycobacterium tuberculosis PPE protein family, similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa), FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa overlap); etc. Q7TW93 No NC_002945.3 Mycobrowser_v2 CDS 3851395 3851844 . + 0 Mb3516 conserved protein Mb3516, -, len: 149 aa. Equivalent to Rv3486, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Conserved hypothetical protein, similar to Q9RC47|YFID|BH3304 HYPOTHETICAL PROTEIN from Bacillus halodurans (129 aa),FASTA scores: opt: 186, E(): 2.1e-05, (40.0% identity in 95 aa overlap); and Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from Vibrio cholerae (148 aa), FASTA scores: opt: 128,E(): 0.15, (35.25% identity in 139 aa overlap). Some similarity to other proteins e.g. P54720|YFID_BACSU HYPOTHETICAL PROTEIN from Bacillus subtilis (134 aa),FASTA scores: opt: 165, E(): 0.00052, (31.75% identity in 126 aa overlap). Equivalent to AAK47949 from Mycobacterium tuberculosis strain CDC1551 (163 aa) but shorter 14 aa. Q7TWE5 No conserved hypotheticals Rv3486 NC_002945.3 Mycobrowser_v2 CDS 3851797 3852927 . - 0 Mb3517c lipF PROBABLE ESTERASE/LIPASE LIPF Mb3517c, lipF, len: 376 aa. Equivalent to esterase/lipase lipF from Mycobacterium bovis BCG strain Korea 1168P (100% identity with 375 aa overlap). 5' extension to annotation based on de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Probable lipF,esterase/lipase (EC 3.-.-.-), highly similar to O53424|LIPU|Rv1076|MTV017.29 PUTATIVE ESTERASE/LIPASE from Mycobacterium tuberculosis (297 aa), and similar to other putative lipases from Mycobacterium tuberculosis e.g. P71759|LIPK|RV2385|MTCY253.36c (306 aa). Equivalent to Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE (PUTATIVE ESTERASE) from Mycobacterium leprae (335 aa). Also similar to esterases and lipases of around 300 aa e.g. Q44087|EST ESTERASE PRECURSOR from Acinetobacter lwoffii (303 aa),P18773|EST_ACICA ESTERASE (EC 3.1.1.-) from Acinetobacter calcoaceticus (303 aa), Q9KIU1 ESTERASE from uncultured bacterium Plasmid pAH116 (308 aa),Q9X8J4|SCE9.22 PUTATIVE ESTERASE from Streptomyces coelicolor (266 aa), etc. Equivalent to AAK47950 from Mycobacterium tuberculosis strain CDC1551 (327 aa). UPDATE: Mb3517c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BNF2 No NC_002945.3 Mycobrowser_v2 CDS 3853290 3853613 . + 0 Mb3518 CONSERVED HYPOTHETICAL PROTEIN Mb3518, -, len: 107 aa. Equivalent to Rv3488, len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 107 aa overlap). Hypothetical protein,similar to various bacterial proteins e.g. O28730|AF1542 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (101 aa), FASTA scores: opt: 321, E(): 6.4e-15, (50.55% identity in 87 aa overlap); O50207 SQ1_IV (FRAGMENT) from Rhodococcus erythropolis (59 aa), FASTA scores: opt: 298,E(): 1.4e-13, (71.2% identity in 59 aa overlap); Q9KFB0|BH0575 BH0575 PROTEIN from Bacillus halodurans (102 aa), FASTA scores: opt: 294, E(): 4.1e-13, (43.15% identity in 95 aa overlap); etc. Also similar to M. tuberculosis P71704|Rv0047c|MTCY21D4.10c (180 aa) (37.8% identity in 82 aa overlap). Q7TWE3 No conserved hypotheticals Rv3488 NC_002945.3 Mycobrowser_v2 CDS 3853695 3853859 . + 0 Mb3519 unknown protein Mb3519, -, len: 54 aa. Equivalent to Rv3489, len: 54 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 54 aa overlap). Hypothetical unknown protein. No similarity with other proteins. Q7TWE2 No conserved hypotheticals Rv3489 NC_002945.3 Mycobrowser_v2 CDS 3853859 3855361 . + 0 Mb3520 otsA alpha, alpha-trehalose-phosphate synthase [udp-forming] otsa (trehalose-6-phosphate synthase) (udp-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-udp glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-udp glucosyl transferase) Mb3520, otsA, len: 500 aa. Equivalent to Rv3490,len: 500 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 500 aa overlap). Probable otsA, alpha,alpha-trehalose-phosphate synthase (EC 2.4.1.15) (see citations below), equivalent to Q50167|OTSA|ML2254 PROBABLE TREHALOSE-PHOSPHATE SYNTHASE from Mycobacterium leprae (498 aa), FASTA scores: opt: 2706, E(): 1.6e-166,(80.3% identity in 497 aa overlap). Also similar to others e.g. Q92410|TPS1_CANAL from Candida albicans (Yeast) (478 aa), FASTA scores: opt: 895, E(): 4.9e-50, (37.15% identity in 479 aa overlap); Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YBR 0922 from Saccharomyces cerevisiae (Baker's yeast) (495 aa), FASTA scores: opt: 847, E(): 6.2e-47, (36.1% identity in 490 aa overlap); BAB48232|MLL0691 from Rhizobium loti (Mesorhizobium loti) (520 aa), FASTA scores: opt: 884,E(): 2.7e-49, (36.2% identity in 478 aa overlap); etc. Equivalent to AAK47953 from Mycobacterium tuberculosis strain CDC1551 (478 aa) but longer 22 aa. X2BP60,Q7TWE1 No virulence, detoxification, adaptation Rv3490 NC_002945.3 Mycobrowser_v2 CDS 3951382 3951648 . - 0 Mb3597c HYPOTHETICAL PROTEIN Mb3597c, -, len: 88 aa. Equivalent to Rv3566A, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein. Q7TW68 No conserved hypotheticals Rv3566A NC_002945.3 Mycobrowser_v2 CDS 3857298 3858992 . - 0 Mb3524c mce4F MCE-FAMILY PROTEIN MCE4F Mb3524c, mce4F, len: 564 aa. Equivalent to Rv3494c,len: 564 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 564 aa overlap). mce4F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to others e.g. Q9CD09|MCE1F|ML2594 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (516 aa), FASTA scores: opt: 1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap); Q9F361|SC8A2.02c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (433 aa), FASTA scores: opt: 570,E(): 3.7e-14, (30.8% identity in 458 aa overlap); etc. Has hydrophobic stretch, possibly a signal peptide at the N-terminus. Q7TWD7 No NC_002945.3 Mycobrowser_v2 CDS 3865720 3866484 . - 0 Mb3531c yrbE4A conserved integral membrane protein yrbe4a. possible abc transporter. Mb3531c, yrbE4A, len: 254 aa. Equivalent to Rv3501c, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 254 aa overlap). yrbE4A,hypothetical unknown integral membrane protein, part of mce4 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa),FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in 247 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa), FASTA scores: opt: 313, E(): 3e-14,(25.7% identity in 241 aa overlap); etc. Q7TWD0 No virulence, detoxification, adaptation Rv3501c NC_002945.3 Mycobrowser_v2 CDS 3859003 3860157 . - 0 Mb3525c lprN POSSIBLE MCE-FAMILY LIPOPROTEIN LPRN (MCE-FAMILY LIPOPROTEIN MCE4E) Mb3525c, lprN, len: 384 aa. Equivalent to Rv3495c,len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 384 aa overlap). Possible lprN (alternate gene name: mce4E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); and O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also similar to others e.g. Q9F360|SC8A2.03c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (413 aa), FASTA scores: opt: 656, E(): 2.2e-32, (37.55% identity in 317 aa overlap); Q9CD10|LPRK|ML2593 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (392 aa), FASTA scores: opt: 616, E(): 5.5e-30,(28.95% identity in 373 aa overlap); etc. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TWD6 No NC_002945.3 Mycobrowser_v2 CDS 3861506 3862579 . - 0 Mb3527c mce4C MCE-FAMILY PROTEIN MCE4C Mb3527c, mce4C, len: 357 aa. Equivalent to Rv3497c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). mce4C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to others e.g. Q9F358|SC8A2.05c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (351 aa), FASTA scores: opt: 658, E(): 1.1e-30, (33.95% identity in 318 aa overlap); Q9CD12|MCE1C|ML2591 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (519 aa), FASTA scores: opt: 555,E(): 1.2e-24, (28.35% identity in 328 aa overlap); etc. Hydrophobic region at N-terminus. Q7TWD4 No NC_002945.3 Mycobrowser_v2 CDS 3862569 3863621 . - 0 Mb3528c mce4B MCE-FAMILY PROTEIN MCE4B Mb3528c, mce4B, len: 350 aa. Equivalent to Rv3498c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 350 aa overlap). mce4B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to others e.g. Q9CD13|MCE1B|ML2590 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (346 aa), FASTA scores: opt: 803, E(): 6.1e-41, (41.05% identity in 346 aa overlap); Q9F357|SC8A2.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (354 aa), FASTA scores: opt: 624,E(): 3.4e-30, (32.55% identity in 338 aa overlap); etc. Hydrophobic region at N-terminus. Q7TWD3 No NC_002945.3 Mycobrowser_v2 CDS 3863621 3864823 . - 0 Mb3529c mce4A MCE-FAMILY PROTEIN MCE4A Mb3529c, mce4A, len: 400 aa. Equivalent to Rv3499c,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 400 aa overlap). mce4A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar to others e.g. Q9F356|SC8A2.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (418 aa), FASTA scores: opt: 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); Q9S4U5|MCE1 MYCOBACTERIAL CELL ENTRY PROTEIN from Mycobacterium bovis BCG (454 aa), FASTA scores: opt: 529,E(): 2.1e-24, (30.35% identity in 448 aa overlap); Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441 aa),FASTA scores: opt: 515, E(): 1.4e-23, (28.35% identity in 430 aa overlap); etc. Contains a possible N-terminal signal sequence. Note that previously known as mce4. Q7TWD2 No NC_002945.3 Mycobrowser_v2 CDS 3864843 3865685 . - 0 Mb3530c yrbE4B conserved integral membrane protein yrbe4b. possible abc transporter. Mb3530c, yrbE4B, len: 280 aa. Equivalent to Rv3500c, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 280 aa overlap). yrbE4B,hypothetical unknown integral membrane protein, part of mce4 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa),FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in 269 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa), FASTA scores: opt: 270, E(): 6e-11,(25.4% identity in 264 aa overlap); etc. Q7TWD1 No virulence, detoxification, adaptation Rv3500c NC_002945.3 Mycobrowser_v2 CDS 3866710 3867663 . - 0 Mb3532c probable short-chain type dehydrogenase/reductase. possible 17-beta-hydroxysteroid dehydrogenase. Mb3532c, -, len: 317 aa. Equivalent to Rv3502c,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to Mycobacterium tuberculosis proteins P71853|Rv3548c|MTCY03C7.08 HYPOTHETICAL 31.1 KDA PROTEIN (304 aa), FASTA scores: opt: 739, E(): 6.2e-35, (45.15% identity in 310 aa overlap); and Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE OXIDOREDUCTASE (247 aa), FASTA scores: opt: 475,E(): 5.1e-20, (40.15% identity in 254 aa overlap). Also similar to various dehydrogenases e.g. Q9I4V1|PA1023 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (305 aa), FASTA scores: opt: 535, E(): 2.3e-23,(37.1% identity in 302 aa overlap); Q9UVH9|FOX2 FOX2 PROTEIN (SDR FAMILY) (1015 aa), FASTA scores: opt: 487,E(): 3.2e-20, (38.4% identity in 276 aa overlap); P22414|FOX2_CANTR PEROXISOMAL HYDRATASE-DEHYDROGENASE,D-3-HYDROXYACYL CoA DEHYDROGENASE (EC 1.1.1.-) (SDR FAMILY) from Candida tropicalis (Yeast) (906 aa) FASTA scores: opt: 481, E(): 6.4e-20, (38.0% identity in 250 aa overlap); P50171|DHB8_MOUSE|HSD17B8|HKE6|H2-KE6 ESTRADIOL 17 BETA-DEHYDROGENASE 8 from Mus musculus (Mouse) (260 aa) FASTA scores: opt: 459, E(): 4.3e-19, (39.75% identity in 259 aa overlap); CAC41362|BKR1 3-OXYACYL-[ACYL-CARRIER PROTEIN] REDUCTASE (EC 1.1.1.100) (FRAGMENT) from Brassica napus (Rape) (317 aa), FASTA scores: opt: 447, E(): 2.4e-18, (39.2% identity in 255 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Start uncertain. Q7TWC9 No intermediary metabolism and respiration Rv3502c NC_002945.3 Mycobrowser_v2 CDS 3867688 3867879 . - 0 Mb3533c fdxD PROBABLE FERREDOXIN FDXD Mb3533c, fdxD, len: 63 aa. Equivalent to Rv3503c,len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 HYPOTHETICAL 9.3 KDA PROTEIN from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 DIOXYGENASE DITA FERREDOXIN COMPONENT from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoacetica (Clostridium thermoaceticum) (63 aa), FASTA scores: opt: 157, E(): 5.4e-05, (36.65% identity in 60 aa overlap); P18325|FER2_STRGO|SUBB from Streptomyces griseolus (64 aa) FASTA scores: opt: 157, E(): 5.5e-05, (39.35% identity in 61 aa overlap); etc. BELONGS TO THE BACTERIAL TYPE FERREDOXIN FAMILY. Q7TWC8 No NC_002945.3 Mycobrowser_v2 CDS 3868094 3869296 . + 0 Mb3534 fadE26 PROBABLE ACYL-COA DEHYDROGENASE FADE26 Mb3534, fadE26, len: 400 aa. Equivalent to Rv3504,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 400 aa overlap). Probable fadE26,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other ACYL-COA DEHYDROGENASES from Mycobacterium tuberculosis e.g. P71858|FADE29|Rv3543c|MTCY03C7.13 (387 aa) FASTA scores: opt: 1031, E(): 7.5e-59, (46.25% identity in 402 aa overlap); and P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FASTA scores: opt: 617, E(): 3.1e-32, (32.6% identity in 423 aa overlap); etc. Also similar to others e.g. Q9A6G3|CC2131 from Caulobacter crescentus (403 aa) FASTA scores: opt: 710, E(): 3.2e-38, (33.4% identity in 413 aa overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 522, E(): 3.7e-26, (34.1% identity in 358 aa overlap); Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa), FASTA scores: opt: 509, E(): 2.6e-25,(34.45% identity in 363 aa overlap); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TWC7 No NC_002945.3 Mycobrowser_v2 CDS 3869321 3870442 . + 0 Mb3535 fadE27 PROBABLE ACYL-COA DEHYDROGENASE FADE27 Mb3535, fadE27, len: 373 aa. Equivalent to Rv3505,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 373 aa overlap). Probable fadE27,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other ACYL-COA DEHYDROGENASES from Mycobacterium tuberculosis e.g. P71857|FADE28|Rv3544c|MTCY03C7.12 (339 aa) FASTA scores: opt: 497, E(): 1.8e-22, (30.3% identity in 343 aa overlap); and P95281|FADE18|Rv1933c|MTCY09F9.31 (363 aa) FASTA scores: opt: 421, E(): 6.4e-18, (32.35% identity in 334 aa overlap). Also similar to other e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 425, E(): 3.5e-18, (30.75% identity in 351 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa) FASTA scores: opt: 317, E(): 1e-11, (32.8% identity in 372 aa overlap); Q9L8Q3|PDTORFO from Pseudomonas stutzeri (Pseudomonas perfectomarina) (513 aa), FASTA scores: opt: 301, E(): 1.2e-10, (25.9% identity in 394 aa overlap); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TWC6 No NC_002945.3 Mycobrowser_v2 CDS 3870513 3872021 . + 0 Mb3536 fadD17 fatty-acid-coa synthetase fadd17 (fatty-acid-coa synthase) (fatty-acid-coa ligase) Mb3536, fadD17, len: 502 aa. Equivalent to Rv3506,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 502 aa overlap). Possible fadD17,fatty-acid-CoA synthetase (ligase) (EC 6.2.1.-), similar to P72007|FADD1|RV1750c|MTCY28.13c|MTCY04C12.34 from Mycobacterium tuberculosis (532 aa), FASTA scores: opt: 666, E(): 9.8e-32, (52.05% identity in 488 aa overlap). Also similar to various ligases/synthetases e.g. Q9EY88|FCS FERULOYL-COA SYNTHETASE from Amycolatopsis sp. HR167 (491 aa), FASTA scores: opt: 490, E(): 2.1e-21,(30.3% identity in 462 aa overlap); BAB33463|ECS0040 (alias AAG54340|CAIC) PROBABLE CROTONOBETAINE/CARNITINE-COA LIGASE from Escherichia coli strain O157:H7 (522 aa), FASTA scores: opt: 478, E(): 1.1e-20, (28.5% identity in 347 aa overlap); Q9KHL1|ENCH PUTATIVE ACYL-COA LIGASE from Streptomyces maritimus (535 aa), FASTA scores: opt: 477, E(): 1.3e-20, (28.7% identity in 453 aa overlap); Q50017|XCLC|ML1051 ACYL-COA SYNTHASE from Mycobacterium leprae (476 aa), FASTA scores: opt: 472, E(): 2.3e-20, (31.35% identity in 469 aa overlap); P31552|CAIC_ECOLI|B0037 from Escherichia coli strain K12 (522 aa), FASTA scores: opt: 467, E(): 4.8e-20, (28.75% identity in 348 aa overlap); Q9KBC2|BH2006 from Bacillus halodurans LONG-CHAIN ACYL-COA SYNTHETASE (LIGASE) (513 aa), FASTA scores: opt: 462, E(): 9.4e-20, (27.65% identity in 463 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. X2BPR1,Q7TWC5 No NC_002945.3 Mycobrowser_v2 CDS 3872192 3876274 . + 0 Mb3537 PE_PGRS53 pe-pgrs family protein pe_pgrs53 Mb3537, PE_PGRS53, len: 1360 aa. Similar to Rv3507,len: 1381 aa, from Mycobacterium tuberculosis strain H37Rv, (93.635% identity in 1414 aa overlap). Member of the Mycobacterium tuberculosis PE protein family, PGRS subfamily of gly-rich proteins, similar to others from M. tuberculosis strains H37Rv and CDC1551 e.g. O06810|Rv1450c|MTCY493.04 (1329 aa), FASTA scores: opt: 2173, E(): 1.4e-135, (51.15% identity in 1412 aa overlap). Equivalent to AAK47970 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but with some minor differences between the proteins. Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 18 bp, 72 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 54 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa versus 1381 aa). Q7TWC4 No NC_002945.3 Mycobrowser_v2 CDS 3876565 3880947 . + 0 Mb3538 PE_PGRS54 pe-pgrs family protein pe_pgrs54 Mb3538, PE_PGRS54, len: 1460 aa. Similar to Rv3508,len: 1901 aa, from Mycobacterium tuberculosis strain H37Rv, (71.06% identity in 1904 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. downstream O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 6598, E(): 0, (71.05% identity in 1533 aa overlap). Equivalent to AAK47971 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but shorter 13 aa and with some minor differences between the proteins. Contains five PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 9 bp (*-cggcgcggg), 27 bp and 18 bp,deletions of 168 bp, 603 bp and 48 bp, and several substitutions lead to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1460 aa versus 1901 aa). Q7TWC3 No NC_002945.3 Mycobrowser_v2 CDS 3881114 3882661 . - 0 Mb3539c ilvX PROBABLE ACETOHYDROXYACID SYNTHASE ILVX (ACETOLACTATE SYNTHASE) Mb3539c, ilvX, len: 515 aa. Equivalent to Rv3509c,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 515 aa overlap). Probable ilvX,acetohydroxyacid synthase (EC 4.1.3.18), equivalent to Mycobacterium leprae protein described as Acetolactate synthase I, valine sensitive, large subunit (EC 4.1.3.18) Q49865|ILVX|ILVI1|B229_C3_222 (515 aa), FASTA scores: opt: 2762, E(): 8.8e-145, (82.9% identity in 515 aa overlap). Also similar to various enzymes (principally acetohydroxyacid/acetolactate synthases) e.g. Q9AB41|CC0393 THIAMINE-PYROPHOSPHATE-REQUIRING ENZYME from Caulobacter crescentus (512 aa), FASTA scores: opt: 1572,E(): 2.8e-79, (50.95% identity in 514 aa overlap); BAB50432|MLL3567 ACETOLACTATE SYNTHASE I from Rhizobium loti (Mesorhizobium loti) (517 aa), FASTA scores: opt: 1440, E(): 5.2e-72, (47.9% identity in 548 aa overlap); P20906|MDLC_PSEPU BENZOYLFORMATE DECARBOXYLASE (EC 4.1.1.7) from Pseudomonas putida (528 aa), FASTA scores: opt: 356, E(): 2.5e-12, (28.1% identity in 530 aa overlap); Q9L123|SC6D11.33c PUTATIVE DECARBOXYLASE from Streptomyces coelicolor (526 aa), FASTA scores: opt: 325,E(): 1.3e-10, (33.2% identity in 530 aa overlap); Q9RDF9|SCC57A.40c PUTATIVE ACETOLACTATE SYNTHASE from Streptomyces coelicolor (564 aa), FASTA scores: opt: 304,E(): 1.9e-09, (28.55% identity in 550 aa overlap); P94783 VALINE-SENSITIVE ACETOHYDROXY ACID SYNTHASE from Citrobacter freundii (561 aa), FASTA scores: opt: 278,E(): 5.1e-08, (25.8% identity in 550 aa overlap); Q42767|AHAS ACETOHYDROXYACID SYNTHASE (EC 4.1.3.18)from Gossypium hirsutum (Upland cotton) (659 aa), FASTA scores: opt: 278, E(): 5.8e-08, (26.15% identity in 558 aa overlap); etc. Note that other Mycobacterium tuberculosis proteins, e.g. O53250|MTV012.17c|ILVB_MYCTU|Rv3003c|MT3083|MTV012.17c,show better similarity to Acetolactate synthase I. SIMILAR TO OTHER ENZYMES WHICH REQUIRE TPP. COFACTOR: THIAMIN PYROPHOSPHATE (BY SIMILARITY). Q7TWC2 No NC_002945.3 Mycobrowser_v2 CDS 3897541 3898122 . - 0 Mb3547c cyp142b PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 CYP142B [SECOND PART] Mb3547c, cyp142b, len: 193 aa. Equivalent to 3' end of Rv3518c, len: 398 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 193 aa overlap). Probable cyp142, cytochrome P450 monoxygenase (EC 1.14.-.-), member of Cytochrome P450 family and similar to many e.g. Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 aa overlap); P33271|CPXK_SACER|CYP107B1 from Saccharopolyspora erythraea (Streptomyces erythraeus) (405 aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also similar to Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa overlap). Equivalent to AAK47979 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but longer 26 aa. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b. Q7TWB4 No NC_002945.3 Mycobrowser_v2 CDS 3882658 3883494 . - 0 Mb3540c conserved protein Mb3540c, -, len: 278 aa. Equivalent to Rv3510c,len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Conserved hypothetical protein, similar to Q50662|Rv2303c|MTCY339.06 HYPOTHETICAL 34.6 KDA PROTEIN from Mycobacterium tuberculosis (307 aa), FASTA scores: opt: 416, E(): 1.2e-19, (35.7% identity in 255 aa overlap). Middle of the putative protein highly similar to N-terminal end of Q49860|B229_C2_182 HYPOTHETICAL 11.0 KDA PROTEIN from Mycobacterium leprae (95 aa), FASTA scores: opt: 304, E(): 7.9e-13, (83.65% identity in 55 aa overlap). Also some similarity with other bacterial proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 293, E(): 9.6e-12, (31.3% identity in 198 aa overlap); Q9XDF3|NONC NONC PROTEIN from Streptomyces griseus subsp. griseus (317 aa), FASTA scores: opt: 270,E(): 3.4e-10, (29.95% identity in 227 aa overlap); Q54229|NONR MACROTETROLIDE ANTIBIOTIC-RESISTANCE PROTEIN from Streptomyces griseus (347 aa), FASTA scores: opt: 270, E(): 3.6e-10, (29.95% identity in 227 aa overlap); etc. Q7TWC1 No conserved hypotheticals Rv3510c NC_002945.3 Mycobrowser_v2 CDS 3889799 3890455 . - 0 Mb3542c fadD18 PROBABLE FATTY-ACID-COA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb3542c, fadD18, len: 218 aa. Equivalent to Rv3513c, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 218 aa overlap). Probable fadD18, fatty-acid-CoA synthetase (C-terminal fragment) (EC 6.2.1.-), almost identical to C-terminal end of downstream O53560|FADD19|Rv3515c|MTV023.22c, probably result of partial gene duplication. Also similar at the C-terminus to other fatty-acid-CoA synthetases e.g. Q9EXL2|FADD from Streptomyces griseus (540 aa), FASTA scores: opt: 586, E(): 1.2e-28, (52.45% identity in 185 aa overlap); AAB87139|MIG MEDIUM CHAIN ACYL-COA SYNTHETASE PRECURSOR from Mycobacterium avium (550 aa), FASTA scores: opt: 506, E(): 9.5e-24, (50.0% identity in 150 aa overlap); Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--COA LIGASE from Caulobacter crescentus (561 aa), FASTA scores: opt: 430, E(): 4.4e-19, (45.75% identity in 153 aa overlap); Q9KDT0|BH1131 ACID-COA LIGASE from Bacillus halodurans (546 aa), FASTA scores: opt: 338, E(): 1.9e-13, (38.05% identity in 142 aa overlap); Q9RTR4|DR1692 LONG-CHAIN FATTY ACID--COA LIGASE from Deinococcus radiodurans (584 aa), FASTA scores: opt: 331, E(): 5.3e-13, (35.15% identity in 145 aa overlap); etc. Start uncertain. Q7TWB9 No lipid metabolism Rv3513c NC_002945.3 Mycobrowser_v2 CDS 3972183 3972977 . - 0 Mb3618c PROBABLE CONSERVED MEMBRANE PROTEIN Mb3618c, -, len: 264 aa. Equivalent to Rv3587c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Probable conserved membrane protein, equivalent to Q9CBJ2|ML1918 HYPOTHETICAL MEMBRANE PROTEIN from Mycobacterium leprae (263 aa), FASTA scores: opt: 1438, E(): 2.4e-57, (77.55% identity in 267 aa overlap). Contains hydrophobic stretch in N-terminus; possible signal sequence. Q7TW51 No cell wall and cell processes Rv3587c NC_002945.3 Mycobrowser_v2 CDS 3890501 3893479 . + 0 Mb3543 PE_PGRS57 pe-pgrs family protein pe_pgrs57 Mb3543, PE_PGRS57, len: 992 aa. Similar to Rv3514,len: 1489 aa, from Mycobacterium tuberculosis strain H37Rv, (80.6% identity in 1133 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47971 (1715 aa) FASTA scores: opt: 6940, E(): 0, (67.0% identity in 1713 aa overlap); and upstream O53553|YZ08_MYCTU|Rv3508|MTV023.15 (1901 aa), FASTA scores: opt: 6598,E(): 0, (71.05% identity in 1533 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 9 bp (*-gcgggcggc) and 285 bp, and deletions of 240 bp, 951 bp and 609 bp, lead to shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (992 aa versus 1489 aa). Q7TWB8 No NC_002945.3 Mycobrowser_v2 CDS 3906820 3907269 . + 0 Mb3557 HYPOTHETICAL PROTEIN Mb3557, -, len: 149 aa. Equivalent to Rv3527, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Hypothetical unknown protein. Q7TWA4 No conserved hypotheticals Rv3527 NC_002945.3 Mycobrowser_v2 CDS 3907694 3908407 . - 0 Mb3558c unknown protein Mb3558c, -, len: 237 aa. Equivalent to Rv3528c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Hypothetical unknown protein. Q7TWA3 No conserved hypotheticals Rv3528c NC_002945.3 Mycobrowser_v2 CDS 3894040 3895686 . - 0 Mb3544c fadD19 fatty-acid-coa ligase fadd19 (fatty-acid-coa synthetase) (fatty-acid-coa synthase) Mb3544c, fadD19, len: 548 aa. Equivalent to Rv3515c, len: 548 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 548 aa overlap). Probable fadD19, fatty-acid-CoA synthetase (EC 6.2.1.-),similar (or with similarity) to many e.g. Q9EXL2|FADD FADD PROTEIN from Streptomyces griseus (540 aa), FASTA scores: opt: 1449, E(): 1.5e-81, (46.0% identity in 535 aa overlap); AAB87139|MIG MEDIUM CHAIN ACYL-COA SYNTHETASE PRECURSOR from Mycobacterium avium (550 aa), FASTA scores: opt: 1226, E(): 7.6e-68, (40.7% identity in 543 aa overlap); Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--COA LIGASE from Caulobacter crescentus (561 aa), FASTA scores: opt: 979, E(): 1.2e-52, (34.05% identity in 531 aa overlap); O28502|AF1772 LONG-CHAIN-FATTY-ACID--COA LIGASE (FADD-7) from Archaeoglobus fulgidus (569 aa), FASTA scores: opt: 560, E(): 6.9e-27, (29.3% identity in 543 aa overlap); Q9A8N2|CC1321 LONG-CHAIN-FATTY-ACID--COA LIGASE from Caulobacter crescentus (583 aa), FASTA scores: opt: 544,E(): 6.7e-26, (27.2% identity in 518 aa overlap); P29212|LCFA_ECOLI|FADD|OLDD|B1805 LONG-CHAIN-FATTY-ACID--COA LIGASE from Escherichia coli strain K12 (561 aa), FASTA scores: opt: 460, E(): 4e-22,(26.3% identity in 567 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Note that upstream MTV023.20c|Rv3513c|fadD18 is identical to C-terminal part of FADD19|Rv3515c|MTV023.22c (probably result of partial gene duplication). X2BNN2,Q7TWB7 No lipid metabolism Rv3515c NC_002945.3 Mycobrowser_v2 CDS 3895760 3896551 . + 0 Mb3545 echA19 POSSIBLE ENOYL-COA HYDRATASE ECHA19 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb3545, echA19, len: 263 aa. Equivalent to Rv3516,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Possible echA19,enoyl-CoA hydratase (EC 4.2.1.17), similar to other e.g. Q9ZHG2|ECHA1 from Rhodococcus fascians (275 aa) FASTA scores: opt: 613, E(): 6.4e-32, (45.15% identity in 259 aa overlap); P76082|PAAF_ECOLI|B1393 from Escherichia coli strain K12 (255 aa), FASTA scores: opt: 523, E(): 3.3e-26,(33.6% identity in 256 aa overlap); Q9I393|PA1629 from Pseudomonas aeruginosa (261 aa), FASTA scores: opt: 475,E(): 3.8e-23, (36.85% identity in 247 aa overlap); etc. Also similar to many carnitine racemases eg BAB52369|MLL6015 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 546, E(): 1.1e-27, (36.65% identity in 251 aa overlap). Similar to several putative enoyl-CoA hydratases from Mycobacterium tuberculosis, e.g. P96404|ECHA1|Rv0222|MTCY08D5.17 (262 aa), FASTA scores: opt: 630, E(): 5.1e-33, (44.5% identity in 254 aa overlap); and O53783|ECHA5|Rv0675|MTV040.03 (263 aa) FASTA scores: opt: 499, E(): 1.1e-24, (40.5% identity in 252 aa overlap). COULD BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Q7TWB6 No NC_002945.3 Mycobrowser_v2 CDS 4031177 4031890 . + 0 Mb3677 PE_PGRS61 pe-pgrs family-related protein pe_pgrs61 Mb3677, PE_PGRS61, len: 237 aa. Similar to Rv3653,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(82.2% identity in 237 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to the C-termini of members of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, e.g. MTCY1A11_25,MTCY28_25, MTCY130_10, MTCY1A10_19, MTCY21B4_13,MTCI418B_6,MTCY28_34, MTV004_1, MTCY441_4; etc. Originally annotated as the second part of a PE-PGRS family protein (Rv3652/PE_PGRS60 being the first part). Start shortened since first submission (-50 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium tuberculosis strain H37Rv, (237 aa versus 195 aa). Q7TW10 No NC_002945.3 Mycobrowser_v2 CDS 3896647 3897486 . + 0 Mb3546 CONSERVED HYPOTHETICAL PROTEIN Mb3546, -, len: 279 aa. Equivalent to Rv3517, len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Hypothetical protein,similar to several hypothetical mycobacterial proteins e.g. P71763|Rv1482c|MTCY277.03c from Mycobacterium tuberculosis strain H37Rv (339 aa) (alias AAK45794|MT1529 from M. tuberculosis strain CDC1551 (292 aa) but longer) FASTA scores: opt: 1040, E(): 3.7e-60, (59.0% identity in 273 aa overlap); O07396|MAV346 from M. avium (346 aa) FASTA scores: opt: 1018, E(): 1e-58, (57.2% identity in 278 aa overlap); O53421|Rv1073|MTV017.26 from Mycobacterium tuberculosis strain H37Rv (283 aa), FASTA scores: opt: 903, E(): 2.4e-51, (48.0% identity in 277 aa overlap); Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa) FASTA scores: opt: 158, E(): 0.0015, (41.8% identity in 55 aa overlap); etc. Q7TWB5 No conserved hypotheticals Rv3517 NC_002945.3 Mycobrowser_v2 CDS 3898119 3898736 . - 0 Mb3548c cyp142a PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 CYP142A [FIRST PART] Mb3548c, cyp142a, len: 205 aa. Equivalent to 5' end of Rv3518c, len: 398 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 197 aa overlap). Probable cyp142, cytochrome P450 monoxygenase (EC 1.14.-.-), member of Cytochrome P450 family and similar to many e.g. Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 aa overlap); P33271|CPXK_SACER|CYP107B1 from Saccharopolyspora erythraea (Streptomyces erythraeus) (405 aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also similar to Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa overlap). Equivalent to AAK47979 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but longer 26 aa. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b. Q7TWB3 No NC_002945.3 Mycobrowser_v2 CDS 3898765 3899475 . + 0 Mb3549 unknown protein Mb3549, -, len: 236 aa. Equivalent to Rv3519, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Hypothetical unknown protein. The C-terminal end is highly similar to N-terminal end of AAK47980|MT3620 HYPOTHETICAL 7.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (73 aa), FASTA scores: opt: 279, E(): 9.4e-12, (95.65% identity in 46 aa overlap). Start uncertain. Q7TWB2 No conserved hypotheticals Rv3519 NC_002945.3 Mycobrowser_v2 CDS 3899540 3900583 . - 0 Mb3550c POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE Mb3550c, -, len: 347 aa. Equivalent to Rv3520c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Possible coenzyme F420-dependent oxidoreductase (EC 1.-.-.-), equivalent to Q9CCV8|ML0348 POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE from Mycobacterium leprae (350 aa), FASTA scores: opt: 2029, E(): 9.1e-120, (86.85% identity in 342 aa overlap). Similar to many coenzyme F420-dependent enzymes (and other proteins) e.g. Q9AD98|SCI52.11c PUTATIVE ATP/GTP-BINDING PROTEIN from Streptomyces coelicolor (351 aa), FASTA scores: opt: 859, E(): 1.6e-46,(41.9% identity in 346 aa overlap); Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (341 aa), FASTA scores: opt: 800, E(): 7.9e-43, (38.95% identity in 339 aa overlap); Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa), FASTA scores: opt: 354, E(): 6.7e-15, (34.2% identity in 336 aa overlap); Q49598|MER COENZYME F420-DEPENDENT N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Methanopyrus kandleri (349 aa), FASTA scores: opt: 283,E(): 1.9e-10, (26.75% identity in 329 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Methanococcus jannaschii (331 aa), FASTA scores: opt: 227,E(): 5.8e-07, (26.35% identity in 334 aa overlap); O27784|MTH1752 COENZYME F420-DEPENDENT N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE from Methanobacterium thermoautotrophicum (321 aa), FASTA scores: opt: 207, E(): 1e-05, (27.4% identity in 336 aa overlap); etc. Also similar to Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 313, E(): 2.5e-12, (28.0% identity in 311 aa overlap). Q7TWB1 No intermediary metabolism and respiration Rv3520c NC_002945.3 Mycobrowser_v2 CDS 3900736 3901647 . + 0 Mb3551 CONSERVED HYPOTHETICAL PROTEIN Mb3551, -, len: 303 aa. Equivalent to Rv3521, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Conserved hypothetical protein, similar to (although longer than) other conserved hypothetical proteins e.g. O29296|AF0966 from Archaeoglobus fulgidus (176 aa), FASTA scores: opt: 286,E(): 5.4e-11, (31.15% identity in 170 aa overlap); O30036|AF0203 from Archaeoglobus fulgidus (149 aa) FASTA scores: opt: 259, E(): 2.3e-09, (33.8% identity in 142 aa overlap); O29297|AF0965 from Archaeoglobus fulgidus (154 aa), FASTA scores: opt: 241, E(): 3.2e-08, (31.4% identity in 137 aa overlap); Q9Y995|APE2390 from Aeropyrum pernix (157 aa), FASTA scores: opt: 204, E(): 6.8e-06, (27.45% identity in 153 aa overlap); BAB60424|TVG1322512 from Thermoplasma volcanium (164 aa), FASTA scores: opt: 183,E(): 0.00015, (29.75% identity in 148 aa overlap); etc. Equivalent to AAK47982 from Mycobacterium tuberculosis strain CDC1551 (334 aa) but shorter 31 aa. Q7TWB0 No conserved hypotheticals Rv3521 NC_002945.3 Mycobrowser_v2 CDS 3901663 3902727 . + 0 Mb3552 ltp4 possible lipid transfer protein or keto acyl-coa thiolase ltp4 Mb3552, -, len: 354 aa. Equivalent to Rv3522, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 354 aa overlap). Possible lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to several e.g. O30103|AF0134 3-KETOACYL-COA THIOLASE (ACAB-4) from Archaeoglobus fulgidus (398 aa) FASTA scores: opt: 352, E(): 5.3e-15, (30.45% identity in 381 aa overlap); O29295|AF0967 3-KETOACYL-COA THIOLASE (ACAB-9) from Archaeoglobus fulgidus (400 aa) FASTA scores: opt: 312, E(): 1.8e-12, (28.05% identity in 367 aa overlap); O29294|AF0968 3-KETOACYL-COA THIOLASE (ACAB-10) from Archaeoglobus fulgidus (388 aa), FASTA scores: opt: 293,E(): 2.9e-11, (25.9% identity in 309 aa overlap); O58409|PH0676 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN (ACETHYL CoA SYNTHETASE) (EC 6.2.1.-) from Pyrococcus horikoshii (389 aa), FASTA scores: opt: 292,E(): 3.3e-11, (25.8% identity in 368 aa overlap); Q9Y9A3|APE2382 LONG HYPOTHETICAL NON SPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (360 aa) FASTA scores: opt: 270, E(): 7.8e-10, (27.25% identity in 363 aa overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (400 aa), FASTA scores: opt: 258, E(): 4.9e-09, (26.45% identity in 306 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TWA9 No lipid metabolism Rv3522 NC_002945.3 Mycobrowser_v2 CDS 3902744 3903928 . + 0 Mb3553 ltp3 probable lipid carrier protein or keto acyl-coa thiolase ltp3 Mb3553, -, len: 394 aa. Equivalent to Rv3523, len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 394 aa overlap). Probable lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16),similar to several e.g. O30037|AF0202 3-KETOACYL-COA THIOLASE (ACAB-6) from Archaeoglobus fulgidus (380 aa) FASTA scores: opt: 782, E(): 1.7e-40, (38.35% identity in 386 aa overlap); Q9Y9A1|APE2384 LONG HYPOTHETICAL NON SPECIFIC LIPID-TRANSFER PROTEIN (ACETHYL CoA SYNTHETASE) (EC 6.2.1.-) from Aeropyrum pernix (394 aa), FASTA scores: opt: 626, E(): 5.9e-31, (35.75% identity in 386 aa overlap); BAB59210|TVG0067506 LIPID TRANSFER PROTEIN from Thermoplasma volcanium (390 aa), FASTA scores: opt: 591,E(): 8.1e-29, (34.35% identity in 384 aa overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (400 aa) FASTA scores: opt: 588, E(): 1.3e-28, (31.6% identity in 408 aa overlap); O30104|AF0133 3-KETOACYL-COA THIOLASE (ACAB-3) from Archaeoglobus fulgidus (411 aa) FASTA scores: opt: 583, E(): 2.6e-28, (39.8% identity in 412 aa overlap); O29811|AF0438 3-KETOACYL-COA THIOLASE (ACAB-8) from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 574, E(): 8.8e-28, (30.95% identity in 388 aa overlap); etc. Q7TWA8 No lipid metabolism Rv3523 NC_002945.3 Mycobrowser_v2 CDS 3903970 3905001 . + 0 Mb3554 PROBABLE CONSERVED MEMBRANE PROTEIN Mb3554, -, len: 343 aa. Equivalent to Rv3524, len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 343 aa overlap). Probable conserved membrane protein, showing some similarity to C-terminal part of putative Mycobacterium tuberculosis proteins O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.08 serine-threonine protein kinase PknD (EC 2.7.1.-) (664 aa) FASTA scores: opt: 727, E(): 8.3e-36, (45.3% identity in 298 aa overlap); O53893|Rv0980c|MTV044.08c PGRS-FAMILY PROTEIN (457 aa), FASTA scores: opt: 208, E(): 4.4e-05,(33.75% identity in 166 aa overlap); and O53891|Rv0978c|MTV044.06c PGRS-FAMILY PROTEIN (331 aa) FASTA scores: opt: 153, E(): 0.062, (30.75% identity in 117 aa overlap). Contains PS00237 G-protein coupled receptors signature. Q7TWA7 No cell wall and cell processes Rv3524 NC_002945.3 Mycobrowser_v2 CDS 3905015 3905539 . - 0 Mb3555c POSSIBLE SIDEROPHORE-BINDING PROTEIN Mb3555c, -, len: 174 aa. Equivalent to Rv3525c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Possible siderophore-binding protein, similar to ferripyochelin binding proteins (and related) e.g. Q9RSN5|DR2089 FERRIPYOCHELIN-BINDING PROTEIN from Deinococcus radiodurans (240 aa), FASTA scores: opt: 472, E(): 3.3e-21, (46.9% identity in 162 aa overlap); O59257|PH1591 LONG HYPOTHETICAL FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus horikoshii (173 aa), FASTA scores: opt: 431,E(): 6.7e-19, (40.0% identity in 170 aa overlap); Q9V158|FBP|PAB0393 FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus abyssi (173 aa), FASTA scores: opt: 429, E(): 8.9e-19, (39.4% identity in 170 aa overlap); BAB47820|MLR0180 FERRIPYOCHELIN BINDING PROTEIN-LIKE from Rhizobium loti (Mesorhizobium loti) (175 aa), FASTA scores: opt: 415, E(): 6.1e-18, (42.55% identity in 141 aa overlap); etc. Q7TWA6 No intermediary metabolism and respiration Rv3525c NC_002945.3 Mycobrowser_v2 CDS 3915767 3916807 . - 0 Mb3564c hsaf PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) Mb3564c, -, len: 346 aa. Equivalent to Rv3534c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Probable 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), highly similar to others e.g. P51015|BPHI_PSESP from Pseudomonas sp. strain LB400 (346 aa), FASTA scores: opt: 1150, E(): 2.3e-61, (51.35% identity in 331 aa overlap); Q52040|BPHX3 from Pseudomonas pseudoalcaligenes (346 aa), FASTA scores: opt: 1147, E(): 3.5e-61, (51.35% identity in 331 aa overlap); P51017|NAHM_PSEPU from Pseudomonas putida (346 aa), FASTA scores: opt: 1145, E(): 4.7e-61, (50.9% identity in 330 aa overlap) (see citation below); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 1133, E(): 2.4e-60,(52.0% identity in 327 aa overlap); O24833|ATDG from Acinetobacter sp (340 aa), FASTA scores: opt: 1132, E(): 2.7e-60, (50.45% identity in 331 aa overlap); etc. Note that also highly similar to Q9ZI56|NAHM 2-OXO-4-HYDROXYPENTANOATE ALDOLASE from Pseudomonas stutzeri (Pseudomonas perfectomarina) (346 aa) FASTA scores: opt: 1168, E(): 2e-62, (51.05% identity in 331 aa overlap) (see citation below). X2BNP9,Q7TW97 No intermediary metabolism and respiration Rv3534c NC_002945.3 Mycobrowser_v2 CDS 3905654 3906814 . + 0 Mb3556 ksha oxygenase component of 3-ketosteroid-9-alpha-hydroxylase ksha Mb3556, -, len: 386 aa. Equivalent to Rv3526, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Hypothetical oxidoreductase (EC 1.-.-.-), highly similar, except in C-terminus (also longer 69 aa), to O69348|ORF12 PROTEIN (function unknown) from Rhodococcus erythropolis (316 aa) FASTA scores: opt: 1137, E(): 6.9e-65, (59.6% identity in 250 aa overlap). Also some similarity with several aminopyrrolnitrin oxidases (PRND proteins, involved in the pathway for pyrrolnitrin biosynthesis, a secondary metabolite derived from tryptophan which has strong anti-fungal activity) e.g. Q9RPG0|PRND from Myxococcus fulvus (379 aa), FASTA scores: opt: 322, E(): 4.4e-13,(25.85% identity in 352 aa overlap); Q9RPG4|PRND from Burkholderia cepacia (Pseudomonas cepacia) (373 aa) FASTA scores: opt: 306, E(): 4.5e-12, (25.2% identity in 373 aa overlap); P95483|PRND from Pseudomonas fluorescens (363 aa), FASTA scores: opt: 305, E(): 5.1e-12, (25.0% identity in 372 aa overlap); etc. And also some similarity to other putative enzymes like dioxygenases, oxidases, vanillate O-demethyl oxygenase, etc. Q7TWA5 No intermediary metabolism and respiration Rv3526 NC_002945.3 Mycobrowser_v2 CDS 3918584 3920275 . + 0 Mb3567 kstd PROBABLE DEHYDROGENASE Mb3567, -, len: 563 aa. Equivalent to Rv3537, len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 563 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to many dehydrogenases or hypothetical proteins e.g. Q9I1M6|PA2243 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (577 aa), FASTA scores: opt: 984, E(): 1.2e-48, (34.75% identity in 573 aa overlap); Q06401|3O1D_COMTE 3-OXOSTEROID 1-DEHYDROGENASE from Comamonas testosteroni (Pseudomonas testosteroni) (573 aa), FASTA scores: opt: 955, E(): 5.5e-47, (33.05% identity in 590 aa overlap); Q9RA02|KSTD1 3-KETOSTEROID DEHYDROGENASE from Rhodococcus erythropolis (510 aa),FASTA scores: opt: 631, E(): 1.4e-28, (39.15% identity in 557 aa overlap); P77815|KSDD 3-KETOSTEROID-1-DEHYDROGENASE from Nocardioides simplex (Arthrobacter simplex) (515 aa),FASTA scores: opt: 469, E(): 2.4e-19, (35.45% identity in 564 aa overlap); etc. Q7TW95 No intermediary metabolism and respiration Rv3537 NC_002945.3 Mycobrowser_v2 CDS 3910253 3911035 . - 0 Mb3560c POSSIBLE OXIDOREDUCTASE Mb3560c, -, len: 260 aa. Equivalent to Rv3530c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. BAB53258|Q987E5|MLL7083 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 405, E(): 5.3e-18, (33.45% identity in 263 aa overlap); Q9VNF3|CG12171 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (257 aa), FASTA scores: opt: 404, E(): 6.1e-18, (32.8% identity in 256 aa overlap); Q9A3X5|CC3076 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus (254 aa), FASTA scores: opt: 400, E(): 1.1e-17,(31.0% identity in 255 aa overlap); BAB50080|MLR3115 DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (259 aa), FASTA scores: opt: 393, E(): 3e-17, (31.9% identity in 254 aa overlap); Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE from Streptomyces antibioticus (273 aa), FASTA scores: opt: 388, E(): 6.3e-17, (31.6% identity in 250 aa overlap); etc. Q7TWA1 No intermediary metabolism and respiration Rv3530c NC_002945.3 Mycobrowser_v2 CDS 3912558 3913778 . + 0 Mb3562 PPE61 ppe family protein ppe61 Mb3562, PPE61, len: 406 aa. Equivalent to Rv3532,len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Member of the Mycobacterium tuberculosis PPE protein family, similar to many, e.g. O53956|Rv1807|MTV049.29 (403 aa), FASTA scores: opt: 954, E(): 1.1e-43, (44.1% identity in 417 aa overlap) Q7TW99 No NC_002945.3 Mycobrowser_v2 CDS 3913920 3915668 . - 0 Mb3563c PPE62 ppe family protein ppe62 Mb3563c, PPE62, len: 582 aa. Equivalent to Rv3533c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 582 aa overlap). Member of the Mycobacterium tuberculosis PPE protein family, similar to many, e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: opt: 2289, E(): 2.3e-95, (63.5% identity in 600 aa overlap). Q7TW98 No NC_002945.3 Mycobrowser_v2 CDS 3916804 3917715 . - 0 Mb3565c hsag PROBABLE ACETALDEHYDE DEHYDROGENASE (ACETALDEHYDE DEHYDROGENASE [ACETYLATING]) Mb3565c, -, len: 303 aa. Equivalent to Rv3535c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Probable acetaldehyde dehydrogenase (EC 1.2.1.10), highly similar to many e.g. BAB62056|TDNI from Pseudomonas putida (302 aa), FASTA scores: opt: 1159, E(): 1.5e-62, (60.45% identity in 301 aa overlap); Q9ZI57|NAHO from Pseudomonas stutzeri (Pseudomonas perfectomarina) (307 aa) FASTA scores: opt: 1151, E(): 4.6e-62, (59.55% identity in 299 aa overlap); Q9F9I4|CDOI from Comamonas sp. JS765 (302 aa) FASTA scores: opt: 1136, E(): 3.6e-61, (60.15% identity in 301 aa overlap); Q51962|NAHO from Pseudomonas putida (307 aa),FASTA scores: opt: 1133, E(): 5.6e-61, (58.55% identity in 299 aa overlap) (see citation below); P77580|MHPF_ECOLI|MHPF|MHPE|B0351 from Escherichia coli strain K12 (316 aa), FASTA scores: opt: 1040, E(): 2.2e-55, (56.85% identity in 306 aa overlap); etc. X2BP90,Q7TTR4 No intermediary metabolism and respiration Rv3535c NC_002945.3 Mycobrowser_v2 CDS 3953411 3954286 . - 0 Mb3600c hsad 4,9-dhsa hydrolase Mb3600c, bphD, len: 291 aa. Equivalent to Rv3569c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Probable bphD,2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (EC 3.7.1.-), highly similar to others e.g. Q9KWQ6|BPHD2 from Rhodococcus sp. RHA1 (292 aa), FASTA scores: opt: 1468,E(): 1.3e-85, (75.5% identity in 294 aa overlap); Q52036 from Pseudomonas putida (286 aa), FASTA scores: opt: 785,E(): 1.9e-42, (45.1% identity in 295 aa overlap); Q52011|BPHD from Pseudomonas pseudoalcaligenes (286 aa),FASTA scores: opt: 774, E(): 9.3e-42, (44.05% identity in 295 aa overlap); P47229|BPHD_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (286 aa) FASTA scores: opt: 772, E(): 1.2e-41, (44.5% identity in 295 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. Q7TW65 No NC_002945.3 Mycobrowser_v2 CDS 3920277 3921137 . + 0 Mb3568 probable dehydrogenase. possible 2-enoyl acyl-coa hydratase. Mb3568, -, len: 286 aa. Equivalent to Rv3538, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 842, E(): 3.6e-44, (48.4% identity in 285 aa overlap); and similar to C-terminal part of other (principally ESTRADIOL 17 BETA-DEHYDROGENASES/17-BETA-HYDROXYSTEROID DEHYDROGENASES) e.g. P70540 PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE II (SDR FAMILY) from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 622, E(): 1.9e-30, (37.45% identity in 283 aa overlap); or P70523|MPF-2 MULTIFUNCTIONAL PROTEIN 2 (SDR FAMILY) (beta-oxidation protein displaying 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity) from Rattus norvegicus (Rat) (734 aa), FASTA scores: opt: 616, E(): 4.3e-30, (37.1% identity in 283 aa overlap); P51659|DHB4_HUMAN|HSD17B4|EDH17B4 ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) from Homo sapiens (Human) (736 aa), FASTA scores: opt: 614, E(): 5.7e-30, (35.9% identity in 284 aa overlap); P97852|DHB4_RAT|HSD17B4|EDH17B4 ESTRADIOL 17 BETA-DEHYDROGENASE from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 613, E(): 6.6e-30, (37.1% identity in 283 aa overlap); Q9DBM3|HSD17B4 ESTRADIOL 17 BETA-DEHYDROGENASE from Mus musculus (Mouse) (735 aa) FASTA scores: opt: 611, E(): 8.7e-30, (36.5% identity in 285 aa overlap); etc. Also similar to Q11198|Rv3389c|MTV004.47c HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 609, E(): 5.3e-30, (39.65% identity in 285 aa overlap). Note that previously known as ufaA2. Q7TW94 No intermediary metabolism and respiration Rv3538 NC_002945.3 Mycobrowser_v2 CDS 3922714 3923874 . - 0 Mb3570c ltp2 probable lipid transfer protein or keto acyl-coa thiolase ltp2 Mb3570c, ltp2, len: 386 aa. Equivalent to Rv3540c,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Probable ltp2,lipid-transfer protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to several e.g. Q9X4X2|DITF DITF PROTEIN (hypothetical protein, similar to non-specific lipid-transfer protein and 3-ketoacyl-CoA thiolase) from Pseudomonas abietaniphila (397 aa), FASTA scores: opt: 665, E(): 5.3e-34, (33.4% identity in 392 aa overlap); O30255|AF2416 3-KETOACYL-COA THIOLASE (ACAB-12) from Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 496,E(): 1.6e-23, (30.35% identity in 389 aa overlap); O28978|AF1291 3-KETOACYL-COA THIOLASE (ACAB-11) from Archaeoglobus fulgidus (392 aa), FASTA scores: opt: 494,E(): 2.2e-23, (30.6% identity in 379 aa overlap); O26884|MTH793 LIPID-TRANSFER PROTEIN (STEROL OR NONSPECIFIC) from Methanobacterium thermoautotrophicum (383 aa), FASTA scores: opt: 487, E(): 5.9e-23, (30.4% identity in 388 aa overlap); etc. Q7TW92 No NC_002945.3 Mycobrowser_v2 CDS 3923874 3924263 . - 0 Mb3571c conserved protein Mb3571c, -, len: 129 aa. Equivalent to Rv3541c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Hypothetical protein,showing some similarity to Q9CBJ7|ML1909 HYPOTHETICAL PROTEIN from Mycobacterium leprae (142 aa) FASTA scores: opt: 110, E(): 1.2, (27.95% identity in 118 aa overlap); and other (see also BLASTP results) e.g. Q9L0M3|SCD82.08 HYPOTHETICAL 15.2 KDA PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 127, E(): 0.086, (27.65% identity in 123 aa overlap). Contains PS00075 Dihydrofolate reductase signature. Q7TW91 No conserved hypotheticals Rv3541c NC_002945.3 Mycobrowser_v2 CDS 3924260 3925195 . - 0 Mb3572c CONSERVED HYPOTHETICAL PROTEIN Mb3572c, -, len: 311 aa. Equivalent to Rv3542c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Hypothetical protein,showing some similarity to other e.g. Q58947|MJ1552 from Methanococcus jannaschii (141 aa) FASTA scores: opt: 177,E(): 0.00065, (46.65% identity in 60 aa overlap); BAB59276|TVG0142586 from Thermoplasma volcanium (135 aa),FASTA scores: opt: 175, E(): 0.00083, (35.65% identity in 87 aa overlap); Q9HI85|TA1457 from Thermoplasma acidophilum (135 aa), FASTA scores: opt: 162, E(): 0.0052,(31.8% identity in 107 aa overlap); etc. Q7TW90 No conserved hypotheticals Rv3542c NC_002945.3 Mycobrowser_v2 CDS 3925192 3926355 . - 0 Mb3573c fadE29 PROBABLE ACYL-COA DEHYDROGENASE FADE29 Mb3573c, fadE29, len: 387 aa. Equivalent to Rv3543c, len: 387 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 387 aa overlap). Probable fadE29, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. Q9A8P3|CC1310 from Caulobacter crescentus (404 aa), FASTA scores: opt: 624, E(): 9.4e-32,(32.75% identity in 400 aa overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 550,E(): 3.9e-27, (33.7% identity in 350 aa overlap); O28976|AF1293 from Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 529, E(): 8.1e-26, (30.0% identity in 393 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. O53549|FADE26|Rv3504|MTV023.11 (400 aa),FASTA scores: opt: 1031, E(): 2.8e-57, (46.0% identity in 402 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TW89 No lipid metabolism Rv3543c NC_002945.3 Mycobrowser_v2 CDS 3926340 3927359 . - 0 Mb3574c fadE28 PROBABLE ACYL-COA DEHYDROGENASE FADE28 Mb3574c, fadE28, len: 339 aa. Equivalent to Rv3544c, len: 339 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 339 aa overlap). Probable fadE28, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 334, E(): 5.1e-13,(27.65% identity in 329 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 278,E(): 1.2e-09, (26.95% identity in 319 aa overlap); O29813|AF0436 from Archaeoglobus fulgidus (382 aa) FASTA scores: opt: 205, E(): 3.5e-05, (24.75% identity in 384 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. O53550|FADE27|Rv3505|MTV023.12 (373 aa) FASTA scores: opt: 497, E(): 7e-23, (30.3% identity in 343 aa overlap); and to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE ACYL-COA DEHYDROGENASE from Mycobacterium leprae (389 aa) FASTA scores: opt: 165, E(): 0.0012, (25.2% identity in 345 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TW88 No lipid metabolism Rv3544c NC_002945.3 Mycobrowser_v2 CDS 3927359 3928660 . - 0 Mb3575c cyp125 PROBABLE CYTOCHROME P450 125 CYP125 Mb3575c, cyp125, len: 433 aa. Equivalent to Rv3545c, len: 433 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 433 aa overlap). Probable cyp125, cytochrome P-450 (EC 1.14.-.-), similar to others e.g. Q59723|LINC|CYP111 from Pseudomonas incognita (406 aa), FASTA scores: opt: 831, E(): 8e-45,(34.75% identity in 406 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 694, E(): 3.3e-36, (32.35% identity in 417 aa overlap); Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 664, E(): 2.5e-34, (34.15% identity in 413 aa overlap); O08469|CPXY_BACSU|CYPA|CYP107J1 from Bacillus subtilis (410 aa), FASTA scores: opt: 579, E(): 5.6e-29, (30.05% identity in 366 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA scores: opt: 1040, E(): 6.1e-58, (40.75% identity in 432 aa overlap). BELONGS TO THE CYTOCHROME P450 FAMILY. X2BP97,P63710 No intermediary metabolism and respiration Rv3545c NC_002945.3 Mycobrowser_v2 CDS 3928772 3929947 . + 0 Mb3576 fadA5 PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA5 (ACETOACETYL-COA THIOLASE) Mb3576, fadA5, len: 391 aa. Equivalent to Rv3546,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 391 aa overlap). Probable fadA5,acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many e.g. Q9AA29|CC0779 from Caulobacter crescentus (390 aa),FASTA scores: opt: 999, E(): 7.1e-54, (43.5% identity in 400 aa overlap); Q9K783|BH3487 from Bacillus halodurans (393 aa), FASTA scores: opt: 843, E(): 2.6e-44, (37.45% identity in 398 aa overlap); Q9RRK9|DR2480 from Deinococcus radiodurans (399 aa), FASTA scores: opt: 826,E(): 2.8e-43, (38.15% identity in 396 aa overlap); P45369|THIL_CHRVI|PHBA from Chromatium vinosum (394 aa) FASTA scores: opt: 790, E(): 4.5e-41, (39.4% identity in 401 aa overlap); etc. Contains PS00737 Thiolases signature 2. BELONGS TO THE THIOLASE FAMILY. Q7TW87 No NC_002945.3 Mycobrowser_v2 CDS 3993842 3996124 . - 0 Mb3640c ftsH MEMBRANE-BOUND PROTEASE FTSH (CELL DIVISION PROTEIN) Mb3640c, ftsH, len: 760 aa. Equivalent to Rv3610c,len: 760 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 760 aa overlap). ftsH, membrane-bound protease (cell division protein) (EC 3.4.24.-) (see citation below), equivalent to Q9CD58|FTSH_MYCLE|ML0222 (alias O69532|FTSH) CELL DIVISION PROTEIN FTSH HOMOLOG from Mycobacterium leprae (787 aa), FASTA scores: opt: 4388, E(): 9.6e-205, (87.2% identity in 790 aa overlap). Also highly similar to many FTSH proteins e.g. O52395|FTSH from Mycobacterium smegmatis (769 aa), FASTA scores: opt: 3976, E(): 7.6e-185, (82.4% identity in 761 aa overlap); Q9X8I4|SCE9.11c from Streptomyces coelicolor (668 aa),FASTA scores: opt: 2417, E(): 1.4e-109, (57.2% identity in 668 aa overlap); P72991|FTH4_SYNY3|SLR1604 from Synechocystis sp. strain PCC 6803 (616 aa), FASTA scores: opt: 1926, E(): 7.2e-86, (49.35% identity in 612 aa overlap); P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from Escherichia coli strain K12 (644 aa), FASTA scores: opt: 1859, E(): 1.3e-82, (48.95% identity in 605 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature. BELONGS TO THE AAA FAMILY OF ATPASES AND PEPTIDASE FAMILY M41 (ZINC METALLOPROTEASE). COFACTOR: BINDS ONE ZINC ION (POTENTIAL). X2BPW9,P0A4V9 No NC_002945.3 Mycobrowser_v2 CDS 3973086 3973709 . - 0 Mb3619c canb beta-carbonic anhydrase canb Mb3619c, -, len: 207 aa. Equivalent to Rv3588c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 207 aa overlap). Probable carbonic anhydrase (EC 4.2.1.1), equivalent to Q9CBJ1|ML1919 PUTATIVE CARBONIC ANHYDRASE from Mycobacterium leprae (213 aa), FASTA scores: opt: 1160, E(): 3.1e-66, (84.55% identity in 207 aa overlap). Also similar to many e.g. Q9X903|SCH35.03 from Streptomyces coelicolor (207 aa),FASTA scores: opt: 689, E(): 1.6e-36, (53.85% identity in 195 aa overlap); Q9RS89|DR2238 from Deinococcus radiodurans (264 aa), FASTA scores: opt: 451, E(): 2e-21,(39.7% identity in 189 aa overlap); Q39589|BETA-CA1 from Chlamydomonas reinhardtii (267 aa) FASTA scores: opt: 419,E(): 2.1e-19, (36.55% identity in 197 aa overlap); etc. Contains PS00704 and PS00705 Prokaryotic-type carbonic anhydrases signature 1 and 2. BELONGS TO THE PLANT AND PROKARYOTIC CARBONIC ANHYDRASE FAMILY. Q7TW50 No intermediary metabolism and respiration Rv3588c NC_002945.3 Mycobrowser_v2 CDS 3930059 3930514 . + 0 Mb3577 ddn deazaflavin-dependent nitroreductase ddn Mb3577, -, len: 151 aa. Equivalent to Rv3547, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa), FASTA scores: opt: 353, E(): 6.3e-17, (42.55% identity in 134 aa overlap); Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa) FASTA scores: opt: 290, E(): 2.1e-12, (38.5% identity in 122 aa overlap) (similarity in N-terminus for this protein); BAB52932|Q988L5|MLL6688 from Rhizobium loti (Mesorhizobium loti) (148 aa), FASTA scores: opt: 105,E(): 3, (26.75% identity in 86 aa overlap). Also similar to mycobacterial hypothetical proteins e.g. Q9ZH81 from M. paratuberculosis (144 aa), FASTA scores: opt: 366, E(): 8.2e-18, (43.9% identity in 123 aa overlap); and Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c from M. tuberculosis (148 aa), FASTA scores: opt: 330, E(): 2.2e-15, (39.75% identity in 151 aa overlap); etc. Q7TW86 No intermediary metabolism and respiration Rv3547 NC_002945.3 Mycobrowser_v2 CDS 3930597 3931511 . - 0 Mb3578c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb3578c, -, len: 304 aa. Equivalent to Rv3548c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases/reductases (generally belonging to the SDR FAMILY) e.g. Q9I4V1|PA1023 from Pseudomonas aeruginosa (305 aa), FASTA scores: opt: 446, E(): 1.7e-17,(43.75% identity in 256 aa overlap); Q9A6K0|CC2093 from Caulobacter crescentus (301 aa) FASTA scores: opt: 437,E(): 5.3e-17, (42.8% identity in 257 aa overlap); Q9HYH8|PA3427 from Pseudomonas aeruginosa (303 aa), FASTA scores: opt: 399, E(): 6.5e-15, (45.5% identity in 257 aa overlap); Q9VXJ0|CG3415 from Drosophila melanogaster (Fruit fly) (598 aa), FASTA scores: opt: 402, E(): 7.5e-15, (40.7% identity in 285 aa overlap); etc. Also highly similar to O53547|Rv3502c|MTV023.09c PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from (317 aa) FASTA scores: opt: 739, E(): 1.6e-33, (45.15% identity in 310 aa overlap); and other proteins from Mycobacterium tuberculosis. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TW85 No intermediary metabolism and respiration Rv3548c NC_002945.3 Mycobrowser_v2 CDS 3931534 3932313 . - 0 Mb3579c PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb3579c, -, len: 259 aa. Equivalent to Rv3549c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases (generally belong to the SDR FAMILY) e.g. Q9UKU3 from Homo sapiens (Human) (270 aa),FASTA scores: opt: 451, E(): 4.8e-21, (38.05% identity in 247 aa overlap); Q9S274|SCI28.09c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 439, E(): 2.4e-20,(36.8% identity in 231 aa overlap); Q9PFI6|XF0671 from Xylella fastidiosa (247 aa), FASTA scores: opt: 437, E(): 3.4e-20, (37.7% identity in 252 aa overlap); etc. Also highly similar to O33308|FABG5|Rv2766c|MTV002.31c ALCOHOL DEHYDROGENASE (SDR FAMILY) from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 504, E(): 2.3e-24, (38.5% identity in 244 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7TW84 No intermediary metabolism and respiration Rv3549c NC_002945.3 Mycobrowser_v2 CDS 3932368 3933111 . + 0 Mb3580 echA20 PROBABLE ENOYL-COA HYDRATASE ECHA20 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb3580, echA20, len: 247 aa. Equivalent to Rv3550,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Probable echA20,enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. Q9A7B0|CC1814 from Caulobacter crescentus (275 aa), FASTA scores: opt: 488, E(): 3.5e-24, (36.4% identity in 239 aa overlap); O84978|PHAA from Pseudomonas putida (293 aa),FASTA scores: opt: 383, E(): 2e-17, (33.85% identity in 254 aa overlap); BAB48479|Q98LI4|MLL1009 from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 378, E(): 3.8e-17, (21.45% identity in 231 aa overlap); etc. COULD BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Q7TW83 No NC_002945.3 Mycobrowser_v2 CDS 3933111 3933989 . + 0 Mb3581 POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT) Mb3581, -, len: 292 aa. Equivalent to Rv3551, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 292 aa overlap). Possible CoA-transferase, alpha subunit (EC 2.8.3.-), similar in part to other CoA-transferases e.g. Q59111|GCTA_ACIFE|GCTA GLUTACONATE COA-TRANSFERASE SUBUNIT A (EC 2.8.3.12) (GCT LARGE SUBUNIT) from Acidaminococcus fermentans (319 aa) FASTA scores: opt: 247, E(): 6.3e-09, (27.35% identity in 307 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA scores: opt: 222, E(): 2.3e-07, (27.55% identity in 243 aa overlap); BAB50895|MLL4183 from Rhizobium loti (Mesorhizobium loti) (285 aa), FASTA scores: opt: 206, E(): 2.8e-06, (27.4% identity in 281 aa overlap); etc. Also some similarity with O06167|SCOA_MYCTU|RVv504c|MT2579|MTCY07A7.10c PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE SUBUNIT A from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 210, E(): 1.4e-06, (25.5% identity in 247 aa overlap). BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT A FAMILY. Note that this putative protein may combine with the putative protein encoded by the downstream ORF Rv3552 to form a CoA-transferase that comprises two subunits. Q7TW82 No intermediary metabolism and respiration Rv3551 NC_002945.3 Mycobrowser_v2 CDS 3933986 3934738 . + 0 Mb3582 POSSIBLE COA-TRANSFERASE (BETA SUBUNIT) Mb3582, -, len: 250 aa. Equivalent to Rv3552, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Possible CoA-transferase, beta subunit (EC 2.8.3.-), similar in part to other CoA-transferases e.g. Q9I6R1|PA0227 from Pseudomonas aeruginosa (260 aa), FASTA scores: opt: 233,E(): 8.6e-08, (24.8% identity in 238 aa overlap); BAB50894|MLL4181 from Rhizobium loti (Mesorhizobium loti) (264 aa), FASTA scores: opt: 210, E(): 2.6e-06, (24.15% identity in 203 aa overlap); and AAK41345|Q97Z51|GCTB from Sulfolobus solfataricus (245 aa), FASTA scores: opt: 122,E(): 1.1, (25.5% identity in 243 aa overlap). POSSIBLY BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT B FAMILY. Note that this putative protein may combine with the putative protein encoded by the upstream ORF Rv3551 to form a CoA-transferase that comprises two subunits. X2BNK8,P63653 No intermediary metabolism and respiration Rv3552 NC_002945.3 Mycobrowser_v2 CDS 3934836 3935903 . + 0 Mb3583 POSSIBLE OXIDOREDUCTASE Mb3583, -, len: 355 aa. Equivalent to Rv3553, len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 355 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar (except in C-terminus) to Q9A327|CC3379 HYPOTHETICAL PROTEIN from Caulobacter crescentus (321 aa), FASTA scores: opt: 639,E(): 4.6e-29, (46.35% identity in 248 aa overlap); and Q9WZQ7|TM0800 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (314 aa), FASTA scores: opt: 622, E(): 4.1e-28, (37.95% identity in 340 aa overlap). Also similar to two TRANS-2-ENOYL-ACP REDUCTASES; Q99YD4|FABK|SPY1751 from Streptococcus pyogenes (323 aa), FASTA scores: opt: 604, E(): 4.4e-27, (33.25% identity in 346 aa overlap); and Q9FBC5|FABK from Streptococcus pneumoniae (324 aa),FASTA scores: opt: 553, E(): 3.3e-24, (32.1% identity in 346 aa overlap); and similar with several 2-NITROPROPANE DIOXYGENASES, e.g. Q9F7P8 from uncultured proteobacterium EBAC31A08 (322 aa), FASTA scores: opt: 505, E(): 1.7e-21,(33.6% identity in 348 aa overlap); Q9FMG0 (alias AAK44141) from Arabidopsis thaliana (Mouse-ear cress) (333 aa), FASTA scores: opt: 489, E(): 1.4e-20, (33.15% identity in 341 aa overlap); O28109|AF2173 (NCD2) from Archaeoglobus fulgidus (274 aa), FASTA scores: opt: 456,E(): 8.9e-19, (36.3% identity in 237 aa overlap); etc. Q7TW81 No intermediary metabolism and respiration Rv3553 NC_002945.3 Mycobrowser_v2 CDS 3938045 3938914 . - 0 Mb3585c conserved protein Mb3585c, -, len: 289 aa. Equivalent to Rv3555c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 289 aa overlap). Hypothetical protein,highly similar to others from Mycobacterium tuberculosis e.g. O53562|AL022022|Rv3517|MTV023.24 (279 aa), FASTA scores: opt: 874, E(): 8.3e-48, (49.45% identity in 275 aa overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FASTA scores: opt: 755, E(): 3e-40, (45.75% identity in 260 aa overlap); O69681|Rv3714c|MTV025.062c (296 aa), FASTA scores: opt: 733, E(): 6.4e-39, (44.1% identity in 281 aa overlap); etc. Also highly similar to other mycobacterial hypothetical proteins e.g. O07396|MAV346 from M. avium (346 aa), FASTA scores: opt: 714, E(): 1.1e-37, (44.6% identity in 260 aa overlap); and Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa), FASTA scores: opt: 130,E(): 0.17, (35.1% identity in 57 aa overlap) (only partial homology with this protein). Shows some similarity to P52392|NHSR_STRAS PUTATIVE NOSIHEPTIDE RESISTANCE REGULATORY PROTEIN (ORF699) from Streptomyces actuosus (233 aa), FASTA scores: opt: 120, E(): 1.9, (25.25% identity in 194 aa overlap). Q7TW79 No conserved hypotheticals Rv3555c NC_002945.3 Mycobrowser_v2 CDS 3939019 3940179 . - 0 Mb3586c fadA6 PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA6 (ACETOACETYL-COA THIOLASE) Mb3586c, fadA6, len: 386 aa. Equivalent to Rv3556c,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Probable fadA6,acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1091, E(): 2.9e-58, (48.1% identity in 399 aa overlap); Q9AAT4|CC0510 from Caulobacter crescentus (391 aa), FASTA scores: opt: 902,E(): 6.6e-47, (40.25% identity in 395 aa overlap); P45359|THL_CLOAB from Clostridium acetobutylicum (392 aa),FASTA scores: opt: 872, E(): 4.2e-45, (37.9% identity in 396 aa overlap); Q9I2A8|ATOB|PA2001 from Pseudomonas aeruginosa (393 aa), FASTA scores: opt: 872, E(): 4.2e-45,(41.3% identity in 397 aa overlap); etc. Contains PS00737 Thiolases signature 2. BELONGS TO THE THIOLASE FAMILY. Q7TW78 No NC_002945.3 Mycobrowser_v2 CDS 3940244 3940846 . - 0 Mb3587c transcriptional regulatory protein (probably tetr-family) Mb3587c, -, len: 200 aa. Equivalent to Rv3557c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Probable transcriptional regulator, tetR family, similar to other e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa) FASTA scores: opt: 326, E(): 2.3e-14, (31.2% identity in 189 aa overlap); Q9HZW2|PA2885 from Pseudomonas aeruginosa (198 aa), FASTA scores: opt: 308, E(): 3.5e-13, (31.55% identity in 187 aa overlap); Q9RFR4 from Pseudomonas fluorescens (207 aa), FASTA scores: opt: 291, E(): 4.7e-12, (29.75% identity in 195 aa overlap); Q9K8P5|BH2958 from Bacillus halodurans (215 aa), FASTA scores: opt: 271, E(): 9.9e-11, (23.95% identity in 192 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O53641|Rv0158|MTV032.01 (214 aa), FASTA scores: opt: 232, E(): 3.5e-08, (25.5% identity in 192 aa overlap); and O06169|Rv2506|MTCY07A7.12 (215 aa), FASTA scores: opt: 215, E(): 4.5e-07, (35.15% identity in 148 aa overlap); etc. SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TW77 No regulatory proteins Rv3557c NC_002945.3 Mycobrowser_v2 CDS 3941195 3942853 . + 0 Mb3588 PPE64 ppe family protein ppe64 Mb3588, PPE64, len: 552 aa. Equivalent to Rv3558,len: 552 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 552 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1908, E(): 1.7e-83, (58.5% identity in 583 aa overlap). Q7TW76 No NC_002945.3 Mycobrowser_v2 CDS 3942862 3943650 . - 0 Mb3589c probable oxidoreductase Mb3589c, -, len: 262 aa. Equivalent to Rv3559c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 262 aa overlap). Putative oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases e.g. Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE (SDR FAMILY) from Streptomyces antibioticus (273 aa), FASTA scores: opt: 510, E(): 2.8e-24, (40.15% identity in 249 aa overlap);Q9L2C9|SC7A8.29 PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 500,E(): 1.1e-23, (41.4% identity in 239 aa overlap); Q9HQ41|FABG|VNG1341G 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE from Halobacterium sp. strain NRC-1 (255 aa) FASTA scores: opt: 500, E(): 1.1e-23, (40.0% identity in 250 aa overlap); etc. Also similar to oxidoreductases from Mycobacterium tuberculosis eg Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE OXIDOREDUCTASE (247 aa), FASTA scores: opt: 497,E(): 1.6e-23, (39.2% identity in 245 aa overlap). Q7TW75 No intermediary metabolism and respiration Rv3559c NC_002945.3 Mycobrowser_v2 CDS 4032347 4032646 . - 0 Mb3679c CONSERVED HYPOTHETICAL PROTEIN Mb3679c, -, len: 99 aa. Equivalent to Rv3655c, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Hypothetical protein,with similarity to Q9X917|SCH5.15c HYPOTHETICAL 15.2 KDA PROTEIN from Streptomyces coelicolor (150 aa) FASTA scores: opt: 211, E(): 7.7e-07, (39.65% identity in 111 aa overlap). Equivalent to AAK48119 from Mycobacterium tuberculosis strain CDC1551 (99 aa) but longer 26 aa at the C-terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa). Q7TW08 No conserved hypotheticals Rv3655c NC_002945.3 Mycobrowser_v2 CDS 3979072 3979899 . + 0 Mb3625 CONSERVED HYPOTHETICAL PROTEIN Mb3625, -, len: 275 aa. Equivalent to Rv3594, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Hypothetical protein,highly similar in part with Q9ZX49|GP29 from Mycobacteriophage TM4 (547 aa), FASTA scores: opt: 526,E(): 1.3e-25, (46.25% identity in 186 aa overlap); and Q9FZS0|LYSA|GP2 from Mycobacterium phage Ms6 (384 aa) FASTA scores: opt: 147, E(): 0.064, (33.35% identity in 84 aa overlap). Q7TW44 No conserved hypotheticals Rv3594 NC_002945.3 Mycobrowser_v2 CDS 3943647 3944804 . - 0 Mb3590c fadE30 PROBABLE ACYL-COA DEHYDROGENASE FADE30 Mb3590c, fadE30, len: 385 aa. Equivalent to Rv3560c, len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 385 aa overlap). Probable fadE30, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 845, E(): 1.6e-47,(39.2% identity in 388 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 734,E(): 2.8e-40, (35.5% identity in 386 aa overlap); Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa),FASTA scores: opt: 656, E(): 3.2e-35, (37.9% identity in 351 aa overlap); etc. Also similar to acyl-CoA dehydrogenases from Mycobacterium tuberculosis e.g. P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FASTA scores: opt: 939, E(): 1.4e-53, (43.8% identity in 404 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TW74 No lipid metabolism Rv3560c NC_002945.3 Mycobrowser_v2 CDS 3944852 3946375 . + 0 Mb3591 fadD3 PROBABLE FATTY-ACID-COA LIGASE FADD3 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb3591, fadD3, len: 507 aa. Equivalent to Rv3561,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 507 aa overlap). Probable fadD3,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many substrate-CoA symthetases/ligases e.g. Q9KBC2|BH2006 LONG-CHAIN ACYL-COA SYNTHETASE from Bacillus halodurans (513 aa), FASTA scores: opt: 821, E(): 1.6e-43, (32.9% identity in 517 aa overlap); Q9EY88|FCS FERULOYL-COA SYNTHETASE from Amycolatopsis sp. HR167 (491 aa) FASTA scores: opt: 767, E(): 3.5e-40, (37.65% identity in 502 aa overlap); Q9ZIP5|MATB MALONYL CoA SYNTHETASE from Rhizobium leguminosarum (504 aa), FASTA scores: opt: 758,E(): 1.3e-39, (33.7% identity in 472 aa overlap); Q9CD27|FADD2|ML2546 ACYL-COA SYNTHASE from Mycobacterium leprae (548 aa), FASTA scores: opt: 700, E(): 5.6e-36,(31.85% identity in 515 aa overlap); P29212|LCFA_ECOLI|FADD|OLDD|B1805 LONG-CHAIN-FATTY-ACID--COA LIGASE from Escherichia coli strain K12 (561 aa), FASTA scores: opt: 532, E(): 6.3e-28,(30.0% identity in 533 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis eg O53306|FADD13|Rv3089|MTV013.10 (503 aa), FASTA scores: opt: 819, E(): 2.1e-43, (35.1% identity in 490 aa overlap). Contains PS00455 Putative AMP-binding domain signature. Q7TW73 No NC_002945.3 Mycobrowser_v2 CDS 3946376 3947509 . + 0 Mb3592 fadE31 PROBABLE ACYL-COA DEHYDROGENASE FADE31 Mb3592, fadE31, len: 377 aa. Equivalent to Rv3562,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 377 aa overlap). Probable fadE31,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa),FASTA scores: opt: 657, E(): 1.7e-34, (36.45% identity in 351 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 653, E(): 3.2e-34, (33.95% identity in 392 aa overlap); Q9EX72|MLHC from Rhodococcus erythropolis (324 aa) FASTA scores: opt: 631, E(): 6.5e-33, (36.95% identity in 330 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),FASTA scores: opt: 347, E(): 1e-15, (28.6% identity in 385 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. P96842|FADE30|Rv3560c|MTCY06G11.07c (385 aa), FASTA scores: opt: 843, E(): 2.3e-46, (38.95% identity in 380 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TW72 No NC_002945.3 Mycobrowser_v2 CDS 3947506 3948465 . + 0 Mb3593 fadE32 PROBABLE ACYL-COA DEHYDROGENASE FADE32 Mb3593, fadE32, len: 319 aa. Equivalent to Rv3563,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 319 aa overlap). Probable fadE32,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 285,E(): 4.1e-10, (30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),FASTA scores: opt: 230, E(): 1.1e-07, (25.5% identity in 357 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis eg P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores: opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TW71 No NC_002945.3 Mycobrowser_v2 CDS 3948462 3949418 . + 0 Mb3594 fadE33 PROBABLE ACYL-COA DEHYDROGENASE FADE33 Mb3594, fadE33, len: 318 aa. Equivalent to Rv3564,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Probable fadE33,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa),FASTA scores: opt: 373, E(): 1.9e-15, (34.3% identity in 338 aa overlap); Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 277, E(): 1.4e-09, (31.95% identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from Streptomyces coelicolor (395 aa), FASTA scores: opt: 273,E(): 2.5e-09, (30.1% identity in 352 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. P96845|FADE32|Rv3563|MTCY06G11.10 (319 aa), FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TW70 No NC_002945.3 Mycobrowser_v2 CDS 3949415 3950581 . + 0 Mb3595 aspB POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB (TRANSAMINASE A) (ASPAT) (GLUTAMIC--OXALOACETIC TRANSAMINASE) (GLUTAMIC--ASPARTIC TRANSAMINASE) Mb3595, aspB, len: 388 aa. Equivalent to Rv3565,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Possible aspB,aspartate aminotransferase (EC 2.6.1.1), similar to many e.g. Q9A5J2|CC2455 AMINOTRANSFERASE CLASS I from Caulobacter crescentus (381 aa), FASTA scores: opt: 1112,E(): 1e-61, (45.85% identity in 384 aa overlap); Q9HV76|PA4722 PROBABLE AMINOTRANSFERASE from Pseudomonas aeruginosa (390 aa), FASTA scores: opt: 863, E(): 3.1e-46,(37.2% identity in 390 aa overlap); Q9RWP3|DR0623 ASPARTATE AMINOTRANSFERASE from Deinococcus radiodurans (388 aa), FASTA scores: opt: 713, E(): 6.3e-37, (35.5% identity in 383 aa overlap); Q9HQK2|ASPC2|VNG1121G ASPARTATE AMINOTRANSFERASE from Halobacterium sp. strain NRC-1 (391 aa), FASTA scores: opt: 710, E(): 9.8e-37,(34.45% identity in 380 aa overlap); O33822|AAT_THEAQ|ASPC ASPARTATE AMINOTRANSFERASE from Thermus aquaticus (383 aa), FASTA scores: opt: 695, E(): 8.2e-36, (35.1% identity in 376 aa overlap); etc. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. BELONGS TO CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE (BY SIMILARITY). Q7TW69 No intermediary metabolism and respiration Rv3565 NC_002945.3 Mycobrowser_v2 CDS 3950546 3951397 . - 0 Mb3596c nat ARYLAMINE N-ACETYLTRANSFERASE NAT (ARYLAMINE ACETYLASE) Mb3596c, nat, len: 283 aa. Equivalent to Rv3566c,len: 283 aa, from Mycobacterium tuberculosis H37Rv,(100.0% identity in 283 aa overlap). nat (alternate gene name: nhoA), arylamine N-acetyltransferase (EC 2.3.1.5) (see citation below), highly similar to O86309|NAT_MYCSM ARYLAMINE N-ACETYLTRANSFERASE from Mycobacterium smegmatis (see citation below) (275 aa), FASTA scores: opt: 1114,E(): 3e-66, (60.95% identity in 274 aa overlap). Also highly similar to others e.g. Q98D42|BAB51429|MLR4870 from Rhizobium loti (Mesorhizobium loti) (278 aa), FASTA scores: opt: 697, E(): 1.1e-38, (44.1% identity in 272 aa overlap); P77567|NHOA_ECOLI|B1463 from Escherichia coli strain K12 (281 aa), FASTA scores: opt: 537, E(): 4.4e-28,(38.85% identity in 273 aa overlap); Q00267|NHOA_SALTY from Salmonella typhimurium (281 aa), FASTA scores: opt: 507, E(): 4.3e-26, (34.8% identity in 273 aa overlap); etc. BELONGS TO THE ARYLAMINE N-ACETYLTRANSFERASE FAMILY. Note that previously known as nhoA (332 aa) and that nucleotide 4007874 has been changed since first submission (G deleted). X2BPU6,P0A5L9 No NC_002945.3 Mycobrowser_v2 CDS 3951934 3952497 . - 0 Mb3598c hsab possible oxidoreductase. possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase. Mb3598c, -, len: 187 aa. Equivalent to Rv3567c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. O69360 ORF61 PROTEIN from Rhodococcus erythropolis (194 aa) FASTA scores: opt: 974, E(): 3e-59, (77.05% identity in 183 aa overlap); Q9JN75|MMYF PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (174 aa), FASTA scores: opt: 451,E(): 1e-23, (43.65% identity in 158 aa overlap); P54990|NTAB_CHEHE|NMOB NITRILOTRIACETATE MONOOXYGENASE COMPONENT B (EC 1.14.13.-) from Chelatobacter heintzii (322 aa), FASTA scores: opt: 409, E(): 1.3e-20, (38.3% identity in 167 aa overlap)Chelatobacter heintzii; AAK62356 PUTATIVE NADH:FMN OXIDOREDUCTASE from Burkholderia sp. DBT1 (177 aa), FASTA scores: opt: 360,E(): 1.6e-17, (36.15% identity in 155 aa overlap). Q7TW67 No intermediary metabolism and respiration Rv3567c NC_002945.3 Mycobrowser_v2 CDS 3963357 3964598 . + 0 Mb3609 arsB2 POSSIBLE ARSENICAL PUMP INTEGRAL MEMBRANE PROTEIN ARSB2 Mb3609, arsB2, len: 413 aa. Equivalent to Rv3578,len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 413 aa overlap). Possible arsB2,arsenical pump integral membrane protein, similar to many e.g. Q9I1J6|ARSB|PA2278 from Pseudomonas aeruginosa (427 aa), FASTA scores: opt: 375, E(): 3.1e-15, (32.15% identity in 429 aa overlap); Q9K8K7|ARSB|BH2999 from Bacillus halodurans (436 aa), FASTA scores: opt: 360, E(): 2.5e-14, (28.7% identity in 432 aa overlap); P52146|ARB2_ECOLI from Escherichia coli (plasmid R46) (429 aa), FASTA scores: opt: 345, E(): 2e-13, (29.8% identity in 426 aa overlap); etc. Also highly similar to Q9KYM0|SC9H11.21c PROBABLE MEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 730,E(): 1.7e-36, (53.95% identity in 443 aa overlap). SEEMS TO BELONG TO THE ARS FAMILY. Q7TW56 No NC_002945.3 Mycobrowser_v2 CDS 3952512 3953414 . - 0 Mb3599c hsac 3,4-dhsa dioxygenase Mb3599c, bphC, len: 300 aa. Equivalent to Rv3568c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 300 aa overlap). Probable bphC,2,3-dihydroxybiphenyl 1,2-dioxygenase (EC 1.13.11.39),highly similar to other e.g. Q9KWQ5|BPHC5 from Rhodococcus sp. RHA1 (300 aa), FASTA scores: opt: 1715, E(): 3.8e-103,(82.15% identity in 297 aa overlap); O50479|EDOB from Rhodococcus rhodochrous (300 aa) FASTA scores: opt: 1714,E(): 4.4e-103, (82.5% identity in 297 aa overlap); O69359|BPHC6 from Rhodococcus erythropolis (300 aa), FASTA scores: opt: 1647, E(): 9.1e-99, (78.25% identity in 299 aa overlap); Q9RBT2|BPHC1 from Pseudomonas sp. SY5 (301 aa) Pseudomonas sp. SY5 (298 aa) FASTA scores: opt: 767,E(): 3.9e-42, (42.8% identity in 299 aa overlap); P47228|BPHC_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (297 aa), FASTA scores: opt: 670, E(): 6.8e-36,(40.55% identity in 296 aa overlap); etc. Contains PS00082 Extradiol ring-cleavage dioxygenases signature. BELONGS TO THE EXTRADIOL RING-CLEAVAGE DIOXYGENASE FAMILY. Q7TW66 No NC_002945.3 Mycobrowser_v2 CDS 4032670 4032876 . - 0 Mb3680c CONSERVED HYPOTHETICAL PROTEIN Mb3680c, -, len: 68 aa. Equivalent to Rv3656c, len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Conserved hypothetical protein, similar to Q9X918|SCH5.16c SMALL HYPOTHETICAL PROTEIN from Streptomyces coelicolor (75 aa), FASTA scores: opt: 129, E(): 0.0039, (40.0% identity in 60 aa overlap). Equivalent to AAK48120 from Mycobacterium tuberculosis strain CDC1551 (42 aa) but longer 26 aa. Q7TW07 No conserved hypotheticals Rv3656c NC_002945.3 Mycobrowser_v2 CDS 3954301 3955485 . - 0 Mb3601c hsaa possible oxidoreductase. possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase. Mb3601c, -, len: 394 aa. Equivalent to Rv3570c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 394 aa overlap). Possible oxidoreductase (EC 1.-.-.-), most similar to hydroxylases and oxygenases (and also some similarity to acyl-coa dehydrogenases) e.g. O69349 HYDROXYLASE from Rhodococcus erythropolis (393 aa), FASTA scores: opt: 958, E(): 1.1e-53, (39.95% identity in 383 aa overlap); P26698|PIGM_RHOSO PIGMENT PROTEIN from Rhodococcus sp. strain ATCC 21145 (387 aa), FASTA scores: opt: 665, E(): 5.4e-35, (32.2% identity in 382 aa overlap); Q9ZGA9|LANZ5 OXYGENASE HOMOLOG from Streptomyces cyanogenus (397 aa) FASTA scores: opt: 588, E(): 4.5e-30, (30.55% identity in 386 aa overlap); Q9F0J3|NCNH HYDROXYLASE from Streptomyces arenae (405 aa), FASTA scores: opt: 580, E(): 1.5e-29,(31.25% identity in 336 aa overlap); O69789|BPFA INDOLE DIOXYGENASE from Rhodococcus opacus (399 aa), FASTA scores: opt: 558, E(): 3.7e-28, (31.8% identity in 387 aa overlap); etc. Q7TW64 No intermediary metabolism and respiration Rv3570c NC_002945.3 Mycobrowser_v2 CDS 3955632 3956708 . + 0 Mb3602 kshb reductase component of 3-ketosteroid-9-alpha-hydroxylase kshb Mb3602, hmp, len: 358 aa. Equivalent to Rv3571,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Possible hmp,oxidoreductase, hemoglobine-related protein (see citation below) (EC 1.-.-.-), similar to several e.g. Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter sp (336 aa) FASTA scores: opt: 748, E(): 1.5e-38, (34.95% identity in 346 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from Pseudomonas putida (337 aa), FASTA scores: opt: 723, E(): 5.2e-37, (36.35% identity in 341 aa overlap); AAK65059|SMA0752 POSSIBLE DIOXYGENASE REDUCTASE SUBUNIT from Rhizobium meliloti (Sinorhizobium meliloti) (353 aa) FASTA scores: opt: 495, E(): 4.9e-23, (31.9% identity in 345 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE (356 aa), FASTA scores: opt: 364, E(): 5.1e-15, (34.45% identity in 357 aa overlap); Q9L131|HMPA FLAVOHEMOPROTEIN from Streptomyces coelicolor (398 aa), FASTA scores: opt: 352, E(): 3e-14, (32.8% identity in 247 aa overlap); etc. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. Note that it has been shown hmp transcription increased at early stationary phase and is lower at late stationary phase and during exponential growth. Q7TW63 No intermediary metabolism and respiration Rv3571 NC_002945.3 Mycobrowser_v2 CDS 3956726 3957256 . + 0 Mb3603 unknown protein Mb3603, -, len: 176 aa. Equivalent to Rv3572, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Hypothetical unknown protein. Q7TW62 No conserved hypotheticals Rv3572 NC_002945.3 Mycobrowser_v2 CDS 3986193 3986276 . - 0 Mb3629A Hypothetical short protein Mb3629A, len: 27 aa. Equivalent to Rv3599c len: 27 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 27 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Hypothetical unknown protein. X2BPD6 No unknown Rv3599c NC_002945.3 Mycobrowser_v2 CDS 3957292 3959427 . - 0 Mb3604c fadE34 PROBABLE ACYL-COA DEHYDROGENASE FADE34 Mb3604c, fadE34, len: 711 aa. Equivalent to Rv3573c, len: 711 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 711 aa overlap). Probable fadE34, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to others, especially in C-terminal half, e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa) FASTA scores: opt: 780, E(): 2.8e-39, (44.1% identity in 347 aa overlap); Q9A6N8|CC2049 from Caulobacter crescentus (401 aa), FASTA scores: opt: 705, E(): 8.7e-35, (41.5% identity in 342 aa overlap); Q9EX72|MLHC from Rhodococcus erythropolis (324 aa), FASTA scores: opt: 673, E(): 6.1e-33, (42.05% identity in 283 aa overlap); P41367|ACDM_PIG|ACADM from Sus scrofa (Pig)(421 aa) FASTA scores: opt: 325, E(): 4.9e- 13, (28.5% identity in 368 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. P95097|FADE22|Rv3061c|MTCY22D7.20 (721 aa), FASTA scores: opt: 1635, E(): 2.7e-90, (42.65% identity in 729 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TW61 No lipid metabolism Rv3573c NC_002945.3 Mycobrowser_v2 CDS 3959699 3960298 . + 0 Mb3605 kstr transcriptional regulatory protein kstr (probably tetr-family) Mb3605, -, len: 199 aa. Equivalent to Rv3574, len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Probable transcriptional regulator tetR family, similar to others e.g. Q9KXK1|SCC53.10 from Streptomyces coelicolor (250 aa) FASTA scores: opt: 492, E(): 4.8e-25, (44.8% identity in 183 aa overlap); Q9RA03|KSTR from Rhodococcus erythropolis (208 aa), FASTA scores: opt: 294, E(): 3.1e-12, (28.9% identity in 187 aa overlap); BAB54261|MLR7895 from Rhizobium loti (Mesorhizobium loti) (193 aa), FASTA scores: opt: 166, E(): 0.00062, (32.05% identity in 78 aa overlap); P17446|BETI_ECOLI|B0313 from Escherichia coli strain K12 (195 aa), FASTA scores: opt: 142, E(): 0.0034,(25. 6% identity in 168 aa overlap); etc. Equivalent to AAK48038 from Mycobacterium tuberculosis strain CDC1551 (243 aa) but shorter 44 aa. Contains possible helix-turn-helix motif from aa 37-58 (+3.70 SD). POSSIBLY BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TW60 No regulatory proteins Rv3574 NC_002945.3 Mycobrowser_v2 CDS 3960304 3961383 . - 0 Mb3606c TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LACI-FAMILY) Mb3606c, -, len: 359 aa. Equivalent to Rv3575c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable transcriptional regulator belonging to lacI family,similar to others e.g. BAB53947|MLL8376 from Rhizobium loti (Mesorhizobium loti) (358 aa), FASTA scores: opt: 707, E(): 2.6e-35, (35.5% identity in 355 aa overlap); Q9RRI9|DR2501 from Deinococcus radiodurans (359 aa) FASTA scores: opt: 544, E(): 1.6e-25, (40.35% identity in 347 aa overlap); Q9RL31|SCF51A.34 from Streptomyces coelicolor (347 aa), FASTA scores: opt: 307, E(): 2.9e-11, (30.0% identity in 330 aa overlap); O87590|CELR_THEFU from Thermomonospora fusca (340 aa), FASTA scores: opt: 280,E(): 1.2e-09, (32.3% identity in 353 aa overlap); P21867|RAFR_ECOLI from Escherichia coli (335 aa) FASTA scores: opt: 241, E(): 2.6e-07, (27.15% identity in 269 aa overlap); etc. Equivalent to AAK48039 from Mycobacterium tuberculosis strain CDC1551 (404 aa) but shorter 45 aa. Contains possible helix-turn-helix motif, at aa 9-30 (+5.86 SD). COULD BELONG TO THE LACI FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TW59 No regulatory proteins Rv3575c NC_002945.3 Mycobrowser_v2 CDS 3961573 3962286 . + 0 Mb3607 lppH POSSIBLE CONSERVED LIPOPROTEIN LPPH Mb3607, lppH, len: 237 aa. Equivalent to Rv3576,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 237 aa overlap). Possible lppH,conserved lipoprotein, similar in part with proteins from Mycobacterium tuberculosis; C-terminus of Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50.16 PROBABLE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (626 aa) FASTA scores: opt: 396, E(): 6.5e-19, (36.0% identity in 200 aa overlap); and with P71740|LPPR|Rv2403c|MTCY253.17 PROBABLE LIPOPROTEIN PROTEIN (251 aa), FASTA scores: opt: 134, E(): 0.087, (22.7% identity in 207 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as pknM. Q7TW58 No cell wall and cell processes Rv3576 NC_002945.3 Mycobrowser_v2 CDS 3962477 3963343 . + 0 Mb3608 CONSERVED HYPOTHETICAL PROTEIN Mb3608, -, len: 288 aa. Equivalent to Rv3577, len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap), (other start sites possible upstream; equivalent to AAK48041 from Mycobacterium tuberculosis strain CDC1551 (379 aa) but shorter 91 aa). Hypothetical protein, showing some similarity to Q9RI88|SCJ11.16c HYPOTHETICAL 37.9 KDA PROTEIN from Streptomyces coelicolor (349 aa) FASTA scores: opt: 285, E(): 1.5e-10, (27.45% identity in 266 aa overlap). Q7TW57 No conserved hypotheticals Rv3577 NC_002945.3 Mycobrowser_v2 CDS 3964401 3965609 . - 0 Mb3610c possible trna/rrna methyltransferase Mb3610c, -, len: 402 aa. Equivalent to Rv3579c,len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 316 aa overlap). Putative tRNA/rRNA methyltransferase (EC 2.1.1.-), equivalent, but longer 31 aa, to Q9CCW4|ML0324 PUTATIVE METHYLTRANSFERASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1517,E(): 3.4e-79, (83.75% identity in 277 aa overlap). Also highly similar to Q9L0Q5|SCD8A.09 from Streptomyces coelicolor (314 aa), FASTA scores: opt: 937, E(): 3.4e-46,(56.75% identity in 319 aa overlap); and similar to others e.g. Q06753|YACO_BACSU from Bacillus subtilis (249 aa),FASTA scores: opt: 616, E(): 4.9e-28, (41.05% identity in 246 aa overlap); Q9KGF2|BH0113 from Bacillus halodurans (249 aa), FASTA scores: opt: 596, E(): 6.7e-27, (38.5% identity in 244 aa overlap); P74328|Y955_SYNY3|SLR0955 from Synechocystis sp. strain PCC 6803 (384 aa), FASTA scores: opt: 585, E(): 4e-26, (35.85% identity in 304 aa overlap); P39290|YJFH_ECOLI|B4180 from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 521, E(): 1.2e-22,(38.1% identity in 244 aa overlap); etc. Equivalent to AAK48043 from Mycobacterium tuberculosis strain CDC1551 (253 aa) but longer 69 aa. POSSIBLY BELONGS TO THE RNA METHYLTRANSFERASE TRMH FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium strain H37Rv (402 aa versus 322 aa). X2BPC3,Q7TW55 No intermediary metabolism and respiration Rv3579c NC_002945.3 Mycobrowser_v2 CDS 4032886 4033461 . - 0 Mb3681c POSSIBLE CONSERVED ALANINE RICH MEMBRANE PROTEIN Mb3681c, -, len: 191 aa. Equivalent to Rv3657c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 191 aa overlap). Possible conserved membrane protein, rich in ala residues, similar to Q9X919|SCH5.17c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 324,E(): 4.7e-12, (40.9% identity in 154 aa overlap). Q7TW06 No cell wall and cell processes Rv3657c NC_002945.3 Mycobrowser_v2 CDS 3965610 3967019 . - 0 Mb3611c cysS1 CYSTEINYL-TRNA SYNTHETASE 1 CYSS1 (CYSTEINE--TRNA LIGASE 1) (CYSRS 1) (CYSTEINE TRANSLASE) Mb3611c, cysS1, len: 469 aa. Equivalent to Rv3580c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable cysS1,cysteinyl-tRNA synthetase (EC 6.1.1.16), equivalent to P57990|SYC1_MYCLE|CYSS1|CYSS|ML0323 CYSTEINYL-TRNA SYNTHETASE 1 from Mycobacterium leprae (473 aa) FASTA scores: opt: 2825, E(): 3.4e-172, (86.5% identity in 467 aa overlap). Also similar to many e.g. Q9L0Q6|SCD8A.08 from Streptomyces coelicolor (613 aa), FASTA scores: opt: 1834, E(): 4.7e-109, (57.5% identity in 461 aa overlap); Q9I2U7|CYSS|PA1795 from Pseudomonas aeruginosa (460 aa) FASTA scores: opt: 1197, E(): 1.2e-68, (41.65% identity in 468 aa overlap); P21888|SYC_ECOLI P21888|CYSS|B0526 from Escherichia coli strain K12 (461 aa), FASTA scores: opt: 1189, E(): 4e-68, (43.0% identity in 463 aa overlap); etc. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. STRONGLY SIMILAR TO METHIONYL-TRNA SYNTHETASE. X2BPV5,P0A635 No NC_002945.3 Mycobrowser_v2 CDS 3967084 3967563 . - 0 Mb3612c ispF PROBABLE 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE ISPF (MECPS) Mb3612c, ispF, len: 159 aa. Equivalent to Rv3581c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable ispF,2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC not defined), equivalent to Q9CCW5|ML0322 PUTATIVE 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE from Mycobacterium leprae (158 aa), FASTA scores: opt: 830,E(): 2.9e-47, (79.1% identity in 158 aa overlap). Also highly similar to others e.g. Q9L0Q7|ISPF_STRCO|SCD8A.07 from Streptomyces coelicolor (170 aa), FASTA scores: opt: 585, E(): 2.9e-31, (56.5% identity in 154 aa overlap); Q9PDT5|ISPF_XYLFA|XF1294 from Xylella fastidiosa (176 aa),FASTA scores: opt: 398, E(): 4.6e-19, (44.9% identity in 156 aa overlap); Q08113|ISDF_RHOCA|ISPDF from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (379 aa), FASTA scores: opt: 387, E(): 4.5e-18, (42.85% identity in 154 aa overlap) (only similar with C-terminal end of this bifunctional protein ISPD and ISPF); Q06756|ISPF_BACSU from Bacillus subtilis (158 aa), FASTA scores: opt: 367,E(): 4.5e-17, (41.2% identity in 153 aa overlap); etc. BELONGS TO THE ISPF FAMILY. X2BNN3,P65184 No NC_002945.3 Mycobrowser_v2 CDS 3996191 3996733 . + 0 Mb3641 HYPOTHETICAL ARGININE AND PROLINE RICH PROTEIN Mb3641, -, len: 180 aa. Equivalent to Rv3611, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 173 aa overlap). Hypothetical unknown arg-, pro-rich protein. Possible ORF containing several direct repeats. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 111 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217 aa). Q7TW38 No conserved hypotheticals Rv3611 NC_002945.3 Mycobrowser_v2 CDS 3967560 3968255 . - 0 Mb3613c ispD 4-diphosphocytidyl-2c-methyl-d-erythritol synthase ispd (mep cytidylyltransferase) (mct) Mb3613c, ispD, len: 231 aa. Equivalent to Rv3582c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 231 aa overlap). Probable ispD,4-diphosphocytidyl-2C-methyl-D-erythritol synthase (EC 2.7.7.-), equivalent to Q9CCW6|ML0321 PUTATIVE 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHASE from Mycobacterium leprae (241 aa), FASTA scores: opt: 694,E(): 1.7e-35, (66.95% identity in 236 aa overlap). Also highly similar to others e.g. Q9L0Q8|ISPD_STRCO|SCD8A.06 from Streptomyces coelicolor (270 aa), FASTA scores: opt: 537, E(): 7.5e-26, (43.4% identity in 242 aa overlap); P74323|ISPD_SYNY3|SLR0951 from Synechocystis sp. strain PCC 6803 (230 aa), FASTA scores: opt: 410, E(): 3.8e-18,(36.15% identity in 224 aa overlap); Q9KGF8|ISPD_BACHD|BH0107 from Bacillus halodurans (228 aa) FASTA scores: opt: 367, E(): 1.6e-15, (34.65% identity in 228 aa overlap); Q08113|ISDF_RHOCA|ISPDF from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (379 aa)FASTA scores: opt: 359, E(): 7.8e-15, (34.1% identity in 223 aa overlap) (only similar with N-terminus of this bifunctional protein ISPD and ISPF); Q46893|ISPD_ECOLI|B2747 from Escherichia coli strain K12 (235 aa), FASTA scores: opt: 336, E(): 1.3e-13, (33.65% identity in 223 aa overlap); etc. BELONGS TO THE ISPD FAMILY. X2BP42,Q7TW54 No NC_002945.3 Mycobrowser_v2 CDS 3968272 3968760 . - 0 Mb3614c possible transcription factor Mb3614c, -, len: 162 aa. Equivalent to Rv3583c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible transcriptional factor, identical to Q9CCW7|ML0320 PUTATIVE TRANSCRIPTION FACTOR from Mycobacterium leprae (165 aa), FASTA scores: opt: 1004, E(): 6.1e-56, (97.55% identity in 162 aa overlap); and Q9ZBM8|MLCB1450.01c PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (94 aa), FASTA scores: opt: 600, E(): 6e-31,(97.85% identity in 94 aa overlap). Also highly similar to others e.g. Q9L0Q9|SCD8A.05 from Streptomyces coelicolor (160 aa), FASTA scores: opt: 878, E(): 4.3e-48, (85.0% identity in 160 aa overlap); Q9K600|BH3935 from Bacillus halodurans (153 aa) FASTA scores: opt: 383, E(): 3.1e-17,(36.4% identity in 151 aa overlap); Q9KD36|BH1383 from Bacillus halodurans (164 aa) FASTA scores: opt: 305, E(): 2.4e-12, (33.55% identity in 164 aa overlap); etc. Q7TW53 No regulatory proteins Rv3583c NC_002945.3 Mycobrowser_v2 CDS 3973708 3974622 . + 0 Mb3620 mutY probable adenine glycosylase muty Mb3620, mutY, len: 304 aa. Equivalent to Rv3589,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Probable mutY,adenine glycosylase (EC 3.2.2.-), equivalent to Q9CBJ0|MUTY|ML1920 PROBABLE DNA GLYCOSYLASE from Mycobacterium leprae (297 aa), FASTA scores: opt: 1592,E(): 2.6e-94, (74.9% identity in 303 aa overlap). Also similar to many DNA glycosylases (generally adenine glycosylases) e.g. Q9S6T7|SCE94.06 from Streptomyces coelicolor (308 aa), FASTA scores: opt: 965, E(): 2.6e-54,(50.5% identity in 297 aa overlap); Q9S6G1|MUTY from Streptomyces antibioticus (307 aa), FASTA scores: opt: 901, E(): 3.1e-50, (48.5% identity in 303 aa overlap); Q9HPQ6|MUTY|VNG1520G from Halobacterium sp. strain NRC-1 (312 aa), FASTA scores: opt: 566, E(): 7.2e-29, (39.85% identity in 296 aa overlap); BAB53965|MLL7523 from Rhizobium loti (Mesorhizobium loti) (396 aa), FASTA scores: opt: 511, E(): 2.8e-25, (39.65% identity in 237 aa overlap); Q05869|MUTY_SALTY|MUTB from Salmonella typhimurium (350 aa), FASTA scores: opt: 421, E(): 3.8e-20, (35.2% identity in 227 aa overlap); etc. COULD BELONG TO THE NTH/MUTY FAMILY. Q7TW49 No information pathways Rv3589 NC_002945.3 Mycobrowser_v2 CDS 3969045 3969593 . + 0 Mb3615 lpqE POSSIBLE CONSERVED LIPOPROTEIN LPQE Mb3615, lpqE, len: 182 aa. Equivalent to Rv3584,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Possible lpqE,conserved lipoprotein, equivalent to Q9ZBM7|MLCB1450.02|LPQE|ML0319 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (183 aa), FASTA scores: opt: 722,E(): 6.2e-37, (63.45% identity in 175 aa overlap). Also similar in part to Q9KK69 EXPORTED PROTEIN 996A010 (FRAGMENT) from Mycobacterium avium (41 aa), FASTA scores: opt: 180, E(): 0.00012, (69.25% identity in 39 aa overlap); and Q9L0R0|SCD8A.04c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (241 aa), FASTA scores: opt: 127,E(): 0.86, (27.15% identity in 173 aa overlap). Equivalent to AAK48048 from Mycobacterium tuberculosis strain CDC1551 (238 aa) but shorter 56 aa. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. X2BPC7,P65309 No cell wall and cell processes Rv3584 NC_002945.3 Mycobrowser_v2 CDS 3969659 3971101 . + 0 Mb3616 radA DNA REPAIR PROTEIN RADA (DNA REPAIR PROTEIN SMS) Mb3616, radA, len: 480 aa. Equivalent to Rv3585,len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Probable radA, DNA repair protein, similar to many e.g. Q9X8L5|SCE94.02 from Streptomyces coelicolor (469 aa), FASTA scores: opt: 1607,E(): 3.1e-84, (56.15% identity in 454 aa overlap); Q9JV51|RADA|NMA0992 from Neisseria meningitidis (serogroup A) (459 aa), FASTA scores: opt: 1275, E(): 2.5e-65, (45.0% identity in 458 aa overlap); and Q9K040|RADA|NMB0782 from Neisseria meningitidis (serogroup B) (459 aa), FASTA scores: opt: 1269, E(): 5.4e-65, (44.5% identity in 456 aa overlap); P37572|RADA_BACSU|SMS from Bacillus subtilis (458 aa), FASTA scores: opt: 1204, E(): 2.7e-61, (39.55% identity in 455 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE RADA FAMILY. X2BPV8,P65954 No information pathways Rv3585 NC_002945.3 Mycobrowser_v2 CDS 3971106 3972182 . + 0 Mb3617 CONSERVED HYPOTHETICAL PROTEIN Mb3617, -, len: 358 aa. Equivalent to Rv3586, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 358 aa overlap). Conserved hypothetical protein, highly similar to Q9X8L6|SCE94.03 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (374 aa),FASTA scores: opt: 1338, E(): 5e-75, (59.95% identity in 347 aa overlap); P37573|YACK_BACSU HYPOTHETICAL 40.7 KDA PROTEIN from Bacillus subtilis (360 aa), FASTA scores: opt: 875, E(): 1.4e-46, (42.15% identity in 344 aa overlap); Q9KGG0|BH0105 HYPOTHETICAL PROTEIN from Bacillus halodurans (357 aa), FASTA scores: opt: 844, E(): 1.1e-44,(40.3% identity in 350 aa overlap); Q9WY43|TM0200 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (357 aa), FASTA scores: opt: 735, E(): 5.7e-38, (39.4% identity in 353 aa overlap). Also some similarity with other proteins. Contains probable coiled-coil from 144 to 179. X2BNN8,Q7TW52 No conserved hypotheticals Rv3586 NC_002945.3 Mycobrowser_v2 CDS 3996648 3996977 . - 0 Mb3642c CONSERVED HYPOTHETICAL PROTEIN Mb3642c, -, len: 109 aa. Equivalent to Rv3612c,len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Conserved hypothetical protein. Residues 58 to 81 highly similar to N-terminal part of AAK46718|MT2424 HYPOTHETICAL 3.9 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (36 aa), FASTA scores: opt: 108, E(): 0.38, (69.25% identity in 26 aa overlap). Q7TW37 No conserved hypotheticals Rv3612c NC_002945.3 Mycobrowser_v2 CDS 4017808 4018002 . - 0 Mb3666c HYPOTHETICAL PROTEIN Mb3666c, -, len: 64 aa. Equivalent to Rv3642c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Hypothetical unknown protein. Q7TW19 No conserved hypotheticals Rv3642c NC_002945.3 Mycobrowser_v2 CDS 3974619 3976373 . - 0 Mb3621c PE_PGRS58 pe-pgrs family protein pe_pgrs58 Mb3621c, PE_PGRS58, len: 584 aa. Equivalent to Rv3590c, len: 584 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 584 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores: opt: 2005,E(): 1.4e-70, (54.95% identity in 646 aa overlap). Q7TW48 No NC_002945.3 Mycobrowser_v2 CDS 3976484 3977257 . - 0 Mb3622c possible hydrolase Mb3622c, -, len: 257 aa. Equivalent to Rv3591c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Possible hydrolase (EC 3.-.-.-), equivalent to Q9CBI9|ML1921 HYPOTHETICAL PROTEIN from Mycobacterium leprae (256 aa) FASTA scores: opt: 1421, E(): 5.6e-83, (78.5% identity in 251 aa overlap). Also similar to others e.g. Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from Streptomyces coelicolor (352 aa),FASTA scores: opt: 193, E(): 5.2e-05, (33.35% identity in 270 aa overlap); O33745|STTC THIOESTERASE (EC 3.1.2.-) from Streptomyces sp (308 aa) FASTA scores: opt: 242, E(): 3.6e-08, (30.35% identity in 270 aa overlap); Q9RK95|SCF1.09 PUTATIVE HYDROLASE from Streptomyces coelicolor (258 aa), FASTA scores: opt: 239, E(): 4.9e-08,(30.75% identity in 247 aa overlap); Q9HZ14|PA3226 PROBABLE HYDROLASE from Pseudomonas aeruginosa (275 aa),FASTA scores: opt: 226, E(): 3.4e-07, (26.6% identity in 252 aa overlap); Q9HPT9|EST|VNG1474G CARBOXYLESTERASE from Halobacterium sp. strain NRC-1 (274 aa), FASTA scores: opt: 215, E(): 1.7e-06, (26.95% identity in 256 aa overlap); etc. Q7TW47 No intermediary metabolism and respiration Rv3591c NC_002945.3 Mycobrowser_v2 CDS 3977272 3977589 . + 0 Mb3623 mhud possible heme degrading protein mhud Mb3623, TB11.2, len: 105 aa. Equivalent to Rv3592,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). TB11.2, conserved hypothetical protein (see citations from 2000 below),equivalent to Q9CBI8|ML1922 HYPOTHETICAL PROTEIN from Mycobacterium leprae (105 aa) FASTA scores: opt: 591, E(): 2.5e-34, (84.6% identity in 104 aa overlap). Shows some similarity with other bacterial hypothetical proteins e.g. Q9RXN8|DR0272 from Deinococcus radiodurans (109 aa), FASTA scores: opt: 178, E(): 1e-05, (34.3% identity in 102 aa overlap); P38049|YHGC_BACSU from Bacillus subtilis (166 aa) FASTA scores: opt: 175, E(): 2.4e-05, (40.85% identity in 71 aa overlap); Q9K649|BH3883 from Bacillus halodurans (102 aa) FASTA scores: opt: 162, E(): 0.00012, (33.75% identity in 80 aa overlap); etc. Q7TW46 No NC_002945.3 Mycobrowser_v2 CDS 3984222 3984560 . - 0 Mb3628c lsr2 iron-regulated h-ns-like protein lsr2 Mb3628c, lsr2, len: 112 aa. Equivalent to Rv3597c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Probable lsr2,identical to P24094|LSR2_MYCLE|ML0234 LSR2 PROTEIN PRECURSOR (15 KDA ANTIGEN) (A15) from Mycobacterium leprae (112 aa), FASTA scores: opt: 698, E(): 6.7e-37, (92.85% identity in 112 aa overlap). Also highly similar to others e.g. Q9X8N1|SCE94.26c from Streptomyces coelicolor (111 aa), FASTA scores: opt: 379, E(): 4.4e-17, (58.05% identity in 112 aa overlap); Q9ETI2|LSR2 from Corynebacterium equii (Rhodococcus equi) (119 aa), FASTA scores: opt: 328, E(): 6.9e-14, (47.5% identity in 120 aa overlap); and Q9RKK8|SCD25.12c from Streptomyces coelicolor (105 aa), FASTA scores: opt: 293, E(): 9.4e-12,(47.75% identity in 111 aa overlap). X2BP54,P65649 No NC_002945.3 Mycobrowser_v2 CDS 4018397 4018588 . + 0 Mb3667 HYPOTHETICAL PROTEIN Mb3667, -, len: 63 aa. Equivalent to Rv3643, len: 63 aa (questionable ORF), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 63 aa overlap). Identical to AAK48106 from Mycobacterium tuberculosis strain CDC1551 (33 aa) but longer 30 aa. Q7TW18 No conserved hypotheticals Rv3643 NC_002945.3 Mycobrowser_v2 CDS 3977567 3978925 . + 0 Mb3624 lpqF PROBABLE CONSERVED LIPOPROTEIN LPQF Mb3624, lpqF, len: 452 aa. Equivalent to Rv3593,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 452 aa overlap). Probable lpqF,conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 PROBALE SECRETED PROTEIN from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also similar to Q9KJ91 HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces clavuligerus (430 aa), FASTA scores: opt: 609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 BETA LACTAMASE-RELATED PROTEIN from Deinococcus radiodurans (499 aa), FASTA scores: opt: 322,E(): 2.5e-12, (28.25% identity in 322 aa overlap). Equivalent to AAK48057 from Mycobacterium tuberculosis strain CDC1551 (438 aa) but longer 14 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TW45 No cell wall and cell processes Rv3593 NC_002945.3 Mycobrowser_v2 CDS 3979813 3981291 . - 0 Mb3626c PE_PGRS59 pe-pgrs family protein pe_pgrs59 Mb3626c, PE_PGRS59, len: 492 aa. Equivalent to 5' end of Rv3595c, len: 439 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 257 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores: opt: 1644, E(): 1.2e-57, (58.75% identity in 492 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (a-*) and a 27 bp insertion (*-gcgcgccggggccaccgtttccgccgg), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa). Q7TW43 No NC_002945.3 Mycobrowser_v2 CDS 3987522 3988451 . - 0 Mb3632c panC pantoate--beta-alanine ligase panc (pantothenate synthetase) (pantoate activating enzyme) Mb3632c, panC, len: 309 aa. Equivalent to Rv3602c,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable panC,pantoate--beta-alanine ligase (EC 6.3.2.1), equivalent to O69524|PANC_MYCLE|ML0230|MLCB2548.01c PANTOATE--BETA-ALANINE LIGASE from Mycobacterium leprae (313 aa), FASTA scores: opt: 1541, E(): 3.4e-84, (82.15% identity in 297 aa overlap). Also similar to others e.g. O67891|PANC_AQUAE|AQ_2132 from Aquifex aeolicus (282 aa) FASTA scores: opt: 774, E(): 8.6e-39, (46.9% identity in 273 aa overlap); Q9HV69|PANC_PSEAE|PA4730 from Pseudomonas aeruginosa (283 aa), FASTA scores: opt: 770, E(): 1.5e-38,(51.45% identity in 276 aa overlap); Q9A6C8|CC2166 from Caulobacter crescentus (285 aa), FASTA scores: opt: 744,E(): 5.2e-37, (47.75% identity in 268 aa overlap); P31663|PANC_ECOLI|B0133 from Escherichia coli strain K12 (283 aa), FASTA scores: opt: 695, E(): 4.1e-34, (46.1% identity in 271 aa overlap); etc. BELONGS TO THE PANTOTHENATE SYNTHETASE FAMILY. X2BP59,P0A5R1 No NC_002945.3 Mycobrowser_v2 CDS 3981399 3983945 . - 0 Mb3627c clpC probable atp-dependent protease atp-binding subunit clpc1 Mb3627c, clpC, len: 848 aa. Equivalent to Rv3596c,len: 848 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 848 aa overlap). Probable clpC,ATP-dependent clp protease ATP-binding subunit (EC 3.4.-.-), equivalent to P24428|CLPC_MYCLE PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium leprae (848 aa), FASTA scores: opt: 5286,E(): 0, (97.15% identity in 845 aa overlap). Also highly similar to members of the clpA/clpB family e.g. Q9S6T8|SCE94.24c from Streptomyces coelicolor (841 aa) FASTA scores: opt: 4399, E(): 0, (81.0% identity in 848 aa overlap); Q9KGG2|CLPC|BH0103 from Bacillus halodurans (813 aa), FASTA scores: opt: 3279, E(): 3.8e-173, (61.9% identity in 808 aa overlap); Q55662|CLPC|SLL0020 from Synechocystis sp. strain PCC 6803 (821 aa), FASTA scores: opt: 3201, E(): 7.6e-169, (60.5% identity in 820 aa overlap); P51332|CLPC_PORPU from Porphyra purpurea (821 aa), FASTA scores: opt: 3045, E(): 3e-160, (57.65% identity in 817 aa overlap); P37571|CLPC_BACSU|MECB from Bacillus subtilis (810 aa), FASTA scores: opt: 2969, E(): 4.6e-156, (61.15% identity in 811 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CLPA/CLPB FAMILY, CLPC SUBFAMILY. X2BNQ0,P0A523 No NC_002945.3 Mycobrowser_v2 CDS 3984664 3986181 . - 0 Mb3629c lysS LYSYL-TRNA SYNTHETASE 1 LYSS (LYSINE--TRNA LIGASE 1) (LYSRS 1) (LYSINE TRANSLASE) Mb3629c, lysS, len: 505 aa. Equivalent to Rv3598c,len: 505 aa, from Mycobacterium tuberculosis H37Rv,(100.0% identity in 505 aa overlap). Probable lysS,lysyl-tRNA synthetase 1 (EC 6.1.1.6), equivalent to P46861|SYK_MYCLE|LYSS|ML0233 LYSYL-TRNA SYNTHETASE from Mycobacterium leprae (507 aa), FASTA scores: opt: 2835,E(): 4.5e-172, (85.45% identity in 501 aa overlap); and similar with C-terminal part of Q9CC23|LYSX|ML1393 C-TERM LYSYL-TRNA SYNTHASE from Mycobacterium leprae (1039 aa) FASTA scores: opt: 1257, E(): 7.6e-72, (44.55% identity in 505 aa overlap). Also similar to others e.g. P37477|SYK_BACSU|LYSS from Bacillus subtilis (499 aa) FASTA scores: opt: 1294, E(): 1.9e-74, (42.35% identity in 498 aa overlap); Q9RHV9|SYK_BACST|LYSS from Bacillus stearothermophilus (494 aa), FASTA scores: opt: 1258, E(): 3.5e-72, (41.15% identity in 498 aa overlap); Q9PEB6|SYK_XYLFA|LYSS|XF1112 from Xylella fastidiosa (506 aa), FASTA scores: opt: 1228, E(): 2.9e-70, (43.05% identity in 495 aa overlap); etc. Also similar to P94974|SYK2_MYCTU|LYSS2|LYSX|Rv1640c|MTCY06H11.04c LYSYL-TRNA SYNTHETASE 2 from Mycobacterium tuberculosis (1172 aa), FASTA scores: opt: 1295, E(): 3.3e-74, (45.65% identity in 506 aa overlap). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. X2BNU4,P67608 No NC_002945.3 Mycobrowser_v2 CDS 3986282 3987100 . - 0 Mb3630c conserved protein Mb3630c, -, len: 272 aa. Equivalent to Rv3600c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, identical to Q9CD56|ML0232 HYPOTHETICAL PROTEIN from Mycobacterium leprae (274 aa),FASTA scores: opt: 1585, E(): 1.3e-92, (90.5% identity in 274 aa overlap). Also highly similar to others e.g. Q9X8N6|SCE94.31c from Streptomyces coelicolor (265 aa) FASTA scores: opt: 878, E(): 3.9e-48, (51.5% identity in 268 aa overlap); and Q9KGH5|BH0086 from Bacillus halodurans (254 aa), FASTA scores: opt: 611, E(): 2.4e-31,(37.5% identity in 264 aa overlap). And similar to various bacterial proteins e.g. Q9F985 PUTATIVE 32 KDA REPLICATION PROTEIN from Bacillus stearothermophilus (258 aa), FASTA scores: opt: 594, E(): 2.8e-30, (37.45% identity in 267 aa overlap); P37564|YACB_BACSU from Bacillus subtilis (233 aa), FASTA scores: opt: 522, E(): 8.8e-26, (38.95% identity in 213 aa overlap); Q9RX54|DR0461 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (262 aa), FASTA scores: opt: 503, E(): 1.5e-24, (38.45% identity in 268 aa overlap); etc. X2BPW6,Q7TW42 No conserved hypotheticals Rv3600c NC_002945.3 Mycobrowser_v2 CDS 3987103 3987522 . - 0 Mb3631c panD PROBABLE ASPARTATE 1-DECARBOXYLASE PRECURSOR PAND (ASPARTATE ALPHA-DECARBOXYLASE) Mb3631c, panD, len: 139 aa. Equivalent to Rv3601c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable panD,aspartate 1-decarboxylase (EC 4.1.1.11), identical to Q9CD57|PAND|ML0231 PUTATIVE ASPARTATE-1-DECARBOXYLASE from Mycobacterium leprae (142 aa), FASTA scores: opt: 733,E(): 5.5e-41, (82.85% identity in 140 aa overlap). Also highly similar to many e.g. CAC44328|PAND from Streptomyces coelicolor (139 aa), FASTA scores: opt: 578,E(): 6.4e-31, (75.0% identity in 120 aa overlap); Q9X4N0|PAND from Corynebacterium glutamicum (Brevibacterium flavum) (136 aa), FASTA scores: opt: 506,E(): 3e-26, (62.2% identity in 135 aa overlap); P52999|PAND_BACSU from Bacillus subtilis (127 aa) FASTA scores: opt: 421, E(): 9.6e-21, (54.75% identity in 123 aa overlap); P31664|PAND_ECOLI|B0131 from Escherichia coli strain K12 (126 aa), FASTA scores: opt: 388, E(): 1.3e-18,(50.45% identity in 113 aa overlap); etc. X2BNQ4,P65661 No NC_002945.3 Mycobrowser_v2 CDS 3988448 3989359 . - 0 Mb3633c CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH PROTEIN Mb3633c, -, len: 303 aa. Equivalent to Rv3603c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Conserved hypothetical ala-, leu-rich protein, identical except at N-terminus (really different) to AAK48066|MT3708 CHALCONE/STILBENE SYNTHASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (361 aa) FASTA scores: opt: 1742, E(): 8.3e-95, (100.0% identity in 275 aa overlap). Equivalent to O69525|MLCB2548.02c|ML0229 HYPOTHETICAL 32.7 KDA PROTEIN from Mycobacterium leprae (309 aa), FASTA scores: opt: 947, E(): 2.4e-48, (67.85% identity in 311 aa overlap). Also highly similar to Q9X845|SCE126.02c HYPOTHETICAL 42.2 KDA PROTEIN from Streptomyces coelicolor (420 aa), FASTA scores: opt: 683,E(): 8.5e-33, (49.3% identity in 284 aa overlap). Q7TW41 No conserved hypotheticals Rv3603c NC_002945.3 Mycobrowser_v2 CDS 3989544 3990737 . - 0 Mb3634c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN RICH IN ALANINE AND ARGININE AND PROLINE Mb3634c, -, len: 397 aa. Equivalent to Rv3604c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Probable conserved ala-, arg-, pro-rich transmembrane protein, equivalent to O69526|MLCB2548.03c|ML0228 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (432 aa), FASTA scores: opt: 869,E(): 2.9e-31, (59.7% identity in 432 aa overlap). Contains two possible membrane-spanning domains. N-terminus shortened since first submission (previously 462 aa). Q7TW40 No cell wall and cell processes Rv3604c NC_002945.3 Mycobrowser_v2 CDS 3991422 3991988 . - 0 Mb3636c folK 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINEPYROPHOSPHOKINASE FOLK (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE) (PPPK) (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE DIPHOSPHOKINASE) (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-DIPHOSPHOKINASE) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN DIPHOSPHOKINASE) Mb3636c, folK, len: 188 aa. Equivalent to Rv3606c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Probable folK,2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase (EC 2.7.6.3), equivalent to O69528|HPPK_MYCLE|FOLK|ML0226MLCB2548.05c 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE from Mycobacterium leprae (191 aa) FASTA scores: opt: 772, E(): 1.2e-44, (63.15% identity in 190 aa overlap). Also similar to many e.g. P71512|HPPK_METEX|FOLK|FOLA from Methylobacterium extorquens (158 aa), FASTA scores: opt: 292, E(): 1.4e-12,(36.85% identity in 171 aa overlap); O33726|HPPK_STRPY|FOLK|SPY1100 from Streptococcus pyogenes (166 aa), FASTA scores: opt: 234, E(): 1.1e-08, (34.3% identity in 175 aa overlap); Q9X8I1|SCE9.08 from Streptomyces coelicolor (203 aa), FASTA scores: opt: 232,E(): 1.7e-08, (43.25% identity in 185 aa overlap); P26281|HPPK_ECOLI|FOLK|B0142 from Escherichia coli strain K12 (158 aa), FASTA scores: opt: 198, E(): 2.6e-06,(32.85% identity in 143 aa overlap); etc. BELONGS TO THE HPPK FAMILY. X2BNQ7,P64144 No NC_002945.3 Mycobrowser_v2 CDS 3991985 3992386 . - 0 Mb3637c folB PROBABLE DIHYDRONEOPTERIN ALDOLASE FOLB (DHNA) Mb3637c, folB, len: 133 aa. Equivalent to Rv3607c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable folB,dihydroneopterin aldolase (EC 4.1.2.25), equivalent to O69529|FOLB_MYCLE|ML0225|MLCB2548.06c PROBABLE DIHYDRONEOPTERIN ALDOLASE from Mycobacterium leprae (132 aa), FASTA scores: opt: 673, E(): 5.1e-37, (74.8% identity in 131 aa overlap). Also similar to many e.g. Q9X8I0|FOLB_STRCO|SCE9.07 from Streptomyces coelicolor (119 aa), FASTA scores: opt: 334, E(): 4.5e-15, (46.15% identity in 117 aa overlap); P74342|FOLB_SYNY3|SLR1626 from Synechocystis sp. strain PCC 6803 (118 aa) FASTA scores: opt: 287, E(): 5e-12, (38.45% identity in 117 aa overlap); P28823|FOLB_BACSU|FOLA from Bacillus subtilis (120 aa), FASTA scores: opt: 283, E(): 9.2e-12, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE DHNA FAMILY. Note that previously known as folX. X2BP64,P0A581 No NC_002945.3 Mycobrowser_v2 CDS 3998327 3999505 . - 0 Mb3646c espa esx-1 secretion-associated protein a, espa Mb3646c, -, len: 392 aa. Equivalent to Rv3616c,len: 392 aa, from Mycobacterium tuberculosis strain H37RV,(99.5% identity in 392 aa overlap). Conserved hypothetical ala-, gly-rich protein, equivalent to Q49722|ML0405|B1620_C2_213|MLCL383.01 HYPOTHETICAL 40.8 KDA PROTEIN from Mycobacterium leprae (394 aa) FASTA scores: opt: 1620, E(): 5.3e-75, (62.7% identity in 394 aa overlap). Also similar to P96213|Rv3864|MTCY01A6.04c HYPOTHETICAL 42.1 KDA PROTEIN from Mycobacterium tuberculosis (402 aa), FASTA scores: opt: 389, E(): 1.1e-12, (31.75% identity in 400 aa overlap). Q7TW34 No cell wall and cell processes Rv3616c NC_002945.3 Mycobrowser_v2 CDS 3992379 3993221 . - 0 Mb3638c folP1 DIHYDROPTEROATE SYNTHASE 1 FOLP (DHPS 1) (DIHYDROPTEROATE PYROPHOSPHORYLASE 1) (DIHYDROPTEROATE DIPHOSPHORYLASE 1) Mb3638c, folP1, len: 280 aa. Equivalent to Rv3608c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable folP1,dihydropteroate synthase 1 (EC 2.5.1.15), equivalent to O69530|FOLP (alias Q9S0T0|FOLP and Q9R2U9|FOLP) DIHYDRONEOPTERIN ALDOLASE from Mycobacterium leprae (284 aa), FASTA scores: opt: 1418, E(): 7.2e-77, (76.75% identity in 284 aa overlap). Also highly similar to many e.g. Q9X8H8|SCE9.05 from Streptomyces coelicolor (288 aa),FASTA scores: opt: 953, E(): 2.4e-49, (56.0% identity in 266 aa overlap); Q9A3I0|CC3224 from Caulobacter crescentus (274 aa), FASTA scores: opt: 682, E(): 2.6e-33, (45.5% identity in 268 aa overlap); P73248|DHPS_SYNY3|FOLP|SLR2026 from Synechocystis sp. strain PCC 6803 (289 aa), FASTA scores: opt: 665, E(): 2.7e-32, (44.55% identity in 265 aa overlap); P26282|DHPS_ECOLI|FOLP|B3177 from Escherichia coli strain K12 (282 aa), FASTA scores: opt: 642, E(): 6.1e-31,(41.95% identity in 274 aa overlap); etc. Contains PS00792 Dihydropteroate synthase signature 1, PS00793 Dihydropteroate synthase signature 2. SIMILAR TO OTHER SPECIES DHPS. X2BNV3,P0A579 No NC_002945.3 Mycobrowser_v2 CDS 3993218 3993826 . - 0 Mb3639c folE GTP CYCLOHYDROLASE I FOLE (GTP-CH-I) Mb3639c, folE, len: 202 aa. Equivalent to Rv3609c,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Probable folE (alternate gene name: gchA), GTP cyclohydrolase I (EC 3.5.4.16), equivalent to O69531|GCH1_MYCLE|FOLE|ML0223|MLCB2548.08c GTP CYCLOHYDROLASE I from Mycobacterium leprae (205 aa) FASTA scores: opt: 1112, E(): 3.8e-63, (81.95% identity in 205 aa overlap). Also highly similar to many e.g. Q9X8I3|GCH1_STRCO|FOLE|SCE9.10c from Streptomyces coelicolor (201 aa), FASTA scores: opt: 873, E(): 4.2e-48,(67.4% identity in 187 aa overlap); Q9KCC7|MTRA|BH1646 from Bacillus halodurans (188 aa), FASTA scores: opt: 757,E(): 8.1e-41, (62.3% identity in 183 aa overlap); P19465|GCH1_BACSU|FOLE|MTRA from Bacillus subtilis (190 aa), FASTA scores: opt: 750, E(): 2.3e-40, (58.95% identity in 190 aa overlap); etc. Contains PS00860 GTP cyclohydrolase I signature 2. BELONGS TO THE GTP CYCLOHYDROLASE I FAMILY. X2BPE3,P64208 No NC_002945.3 Mycobrowser_v2 CDS 3997272 3997826 . - 0 Mb3644c espd esx-1 secretion-associated protein espd Mb3644c, -, len: 184 aa. Equivalent to Rv3614c,len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Conserved hypothetical protein, equivalent to Q49730|ML0407|B1620_C3_264|MLCL383.03 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium leprae (216 aa) FASTA scores: opt: 899, E(): 1.7e-51, (71.3% identity in 188 aa overlap); and similar to two hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa), FASTA scores: opt: 285, E(): 1.2e-11, (38.35% identity in 172 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 289, E(): 1.2e-11, (38.95% identity in 172 aa overlap). Also highly similar to O69732|Rv3867|MTV027.02 HYPOTHETICAL 19.9 KDA PROTEIN from Mycobacterium tuberculosis (183 aa), FASTA scores: opt: 563, E(): 1e-29,(54.9% identity in 173 aa overlap). Q7TW35 No cell wall and cell processes Rv3614c NC_002945.3 Mycobrowser_v2 CDS 3997942 3998253 . - 0 Mb3645c espc esx-1 secretion-associated protein espc Mb3645c, -, len: 103 aa. Equivalent to Rv3615c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Conserved hypothetical protein, equivalent to Q49723|ML0406|B1620_C2_214|MLCL383 HYPOTHETICAL 11.1 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 364, E(): 4.1e-18, (60.85% identity in 92 aa overlap). Also shows similarity to P96212|Rv3865|MTCY01A6.03 HYPOTHETICAL 10.6 KDA PROTEIN from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 198, E(): 6.8e-07, (36.25% identity in 102 aa overlap). X2BPX2 No cell wall and cell processes Rv3615c NC_002945.3 Mycobrowser_v2 CDS 3999971 4000486 . + 0 Mb3647 lpqG PROBABLE CONSERVED LIPOPROTEIN LPQG Mb3647, lpqG, len: 171 aa. Equivalent to 3' end of Rv3623, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 171 aa overlap). Probable lpqG, conserved lipoprotein, showing some similarity with hypothetical proteins e.g. Q57432 from Methanosarcina barkeri (251 aa), FASTA scores: opt: 319,E(): 6.8e-12, (31.2% identity in 218 aa overlap); Q9PEA5|XF1123 OUTER MEMBRANE PROTEIN from Xylella fastidiosa (242 aa) FASTA scores: opt: 312, E(): 1.7e-11,(28.25% identity in 237 aa overlap); BAB49547|MLR2408 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (236 aa), FASTA scores: opt: 304, E(): 5e-11,(27.05% identity in 244 aa overlap); etc. Has suitable signal peptide and prokaryotic membrane lipoprotein lipid attachment site (PS00013). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 5894 bp deletion leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa). Q7TW33 No NC_002945.3 Mycobrowser_v2 CDS 4000491 4001141 . - 0 Mb3648c hpt HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE HPT (HGPRT) (HGPRTase) (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE) (IMP PYROPHOSPHORYLASE) (IMP DIPHOSPHORYLASE) (TRANSPHOSPHORIBOSYLTRANSFERASE) (GUANINE PHOSPHORIBOSYLTRANSFERASE) Mb3648c, hpt, len: 216 aa. Equivalent to Rv3624c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Probable hpt (alternate gene name: hprT), hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) (but seems to have a 35 aa extension at N-terminus), equivalent to other mycobacterial hypoxanthine-guanine phosphoribosyltransferases e.g. P96794 from Mycobacterium avium (203 aa), FASTA scores: opt: 1136, E(): 1.2e-65,(88.5% identity in 200 aa overlap); and O69537|HPT|ML0214 from Mycobacterium leprae (213 aa), FASTA scores: opt: 1115, E(): 2.8e-64, (81.6% identity in 212 aa overlap). Also similar to others e.g. Q9X8I5|SCE9.12c from Streptomyces coelicolor (187 aa), FASTA scores: opt: 724,E(): 2.4e-39, (60.55% identity in 180 aa overlap); P37472|HPRT_BACSU|HPT from Bacillus subtilis (180 aa) FASTA scores: opt: 574, E(): 9.1e-30, (48.6% identity in 181 aa overlap); etc. Equivalent to AAK48087 from Mycobacterium tuberculosis strain CDC1551 (202 aa) but longer 14 aa. Contains PS00103 Purine/pyrimidine phosphoribosyltransferases signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. X2BNW2,P0A5T1 No NC_002945.3 Mycobrowser_v2 CDS 4001138 4002109 . - 0 Mb3649c mesJ POSSIBLE CELL CYCLE PROTEIN MESJ Mb3649c, mesJ, len: 323 aa. Equivalent to Rv3625c,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Possible mesJ, cell cycle protein, equivalent to O69538|Y0C5_MYCLE|ML0213|MLCB2548.18c HYPOTHETICAL 34.1 KDA PROTEIN from Mycobacterium leprae (323 aa) FASTA scores: opt: 1592, E(): 9e-92, (78.0% identity in 327 aa overlap). Similar to bacterial hypothetical proteins Q9X8I6|SCE9.13c from Streptomyces coelicolor (352 aa) FASTA scores: opt: 705, E(): 1.4e-36, (47.85% identity in 305 aa overlap); and Q9HXZ3|PA3638 from Pseudomonas aeruginosa (442 aa), FASTA scores: opt: 382, E(): 2e-16,(40.6% identity in 271 aa overlap). But also similar (or with similarity) to bacterial cell cycle proteins (MESJ) e.g. Q9KPX0|VC2242 MESJ PROTEIN from Vibrio cholerae (440 aa), FASTA scores: opt: 363, E(): 3e-15, (34.8% identity in 253 aa overlap); Q9RV23|DR1207 (600 aa) CELL CYCLE PROTEIN MESJ (PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN) from Deinococcus radiodurans (600 aa), FASTA scores: opt: 310, E(): 7.6e-12, (36.6% identity in 265 aa overlap) (similar only at the N-terminal end); Q9PFJ8|XF0659 CELL CYCLE PROTEIN from Xylella fastidiosa (437 aa), FASTA scores: opt: 301, E(): 2.1e-11, (35.05% identity in 271 aa overlap); P52097|MESJ_ECOLI|B0188 PUTATIVE CELL CYCLE PROTEIN MESJ from Escherichia coli strain K12(432 aa) FASTA scores: opt: 299, E(): 2.8e-11, (34.65% identity in 277 aa overlap); etc. BELONGS TO THE UPF0072 (MESJ/YCF62) FAMILY. X2BPE9,P67152 No NC_002945.3 Mycobrowser_v2 CDS 4002088 4003140 . - 0 Mb3650c CONSERVED HYPOTHETICAL PROTEIN Mb3650c, -, len: 350 aa. Equivalent to Rv3626c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 350 aa overlap). Conserved hypothetical protein, similar to Q9X8I7|SCE9.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (375 aa) FASTA scores: opt: 720, E(): 2.2e-38, (41.55% identity in 361 aa overlap); and shows some similarity to Q9HPS0|VNG1497C HYPOTHETICAL PROTEIN (317 aa) FASTA scores: opt: 226, E(): 4.5e-07, (29.7% identity in 347 aa overlap). Contains neutral zinc metallopeptidases,zinc-binding region signature (PS00142). Q7TW32 No conserved hypotheticals Rv3626c NC_002945.3 Mycobrowser_v2 CDS 4003137 4004522 . - 0 Mb3651c conserved protein Mb3651c, -, len: 461 aa. Equivalent to Rv3627c,len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 461 aa overlap). Hypothetical ala-rich protein which may have cleavable signal peptide at N-terminal end. Equivalent to O69539|MLCB2548.20c|ML0211 HYPOTHETICAL 47.2 KDA PROTEIN from Mycobacterium leprae (461 aa), FASTA scores: opt: 2295, E(): 3.5e-116, (76.2% identity in 462 aa overlap); and C-terminal end shows similarity with O05758|MLCB5.28c HYPOTHETICAL 24.1 KDA PROTEIN from Mycobacterium leprae (225 aa), FASTA scores: opt: 268, E(): 1.8e-07, (32.25% identity in 220 aa overlap). Also similar (or with similarity) to various proteins (notably penicillin binding proteins) e.g. Q9X8I8|SCE9.15c HYPOTHETICAL 45.9 KDA PROTEIN from Streptomyces coelicolor (459 aa) FASTA scores: opt: 707,E(): 8.3e-31, (35.75% identity in 439 aa overlap); Q9Z541|SC9B2.18c PUTATIVE CARBOXYPEPTIDASE from Streptomyces coelicolor (451 aa), FASTA scores: opt: 450,E(): 5.3e-17, (31.75% identity in 469 aa overlap); Q9JVV4|NMA0665 PUTATIVE PEPTIDASE from Neisseria meningitidis (serogroup A) (or Q9JY10|NMB1797 from serogroup B) (469 aa), FASTA scores: opt: 269, E(): 3e-07,(26.15% identity in 463 aa overlap); O85665|PBP3 PENICILLIN BINDING PROTEIN 3 from Neisseria gonorrhoeae (469 aa), FASTA scores: opt: 265, E(): 4.9e-07, (31.85% identity in 201 aa overlap); P45161|PBP4_HAEIN|DACB|HI1330 PENICILLIN-BINDING PROTEIN 4 PRECURSOR/PEPTIDASE (479 aa) FASTA scores: opt: 230, E(): 3.8e-05, (27.9% identity in 394 aa overlap); P24228|PBP4_ECOLI|DACB|B3182 PENICILLIN-BINDING PROTEIN 4 PRECURSOR from Escherichia coli strain K12 (477 aa), FASTA scores: opt: 166, E(): 0.1, (28.2% identity in 408 aa overlap); etc. Q7TW31 No conserved hypotheticals Rv3627c NC_002945.3 Mycobrowser_v2 CDS 4004660 4005148 . + 0 Mb3652 ppa INORGANIC PYROPHOSPHATASE PPA (PYROPHOSPHATE PHOSPHO-HYDROLASE) (PPASE) (INORGANIC DIPHOSPHATASE) (DIPHOSPHATE PHOSPHO-HYDROLASE) Mb3652, ppa, len: 162 aa. Equivalent to Rv3628,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). ppa, inorganic pyrophosphatase (EC 3.6.1.1) (see first citation),identical to O69540|IPYR_MYCLEPPA|ML0210|MLCB2548.21 INORGANIC PYROPHOSPHATASE from Mycobacterium leprae (162 aa) FASTA scores: opt: 1018, E(): 1.3e-59, (89.5% identity in 162 aa overlap). Also highly similar to many bacterial pyrophosphatases e.g. Q9X8I9|IPYR_STRCO|PPA|SCE9.16 from Streptomyces coelicolor (163 aa), FASTA scores: opt: 773,E(): 1.3e-43, (67.5% identity in 163 aa overlap); O05545|IPYR_GLUOX|PPA from Gluconobacter oxydans (Gluconobacter suboxydans) (176 aa), FASTA scores: opt: 553, E(): 3.2e-29, (53.8% identity in 145 aa overlap); P77992|IPYR_THELI|PPA from Thermococcus litoralis (176 aa) FASTA scores: opt: 537, E(): 3.5e-28, (49.35% identity in 152 aa overlap); P50308|IPYR_SULAC|PPA from Sulfolobus acidocaldarius (173 aa), FASTA scores: opt: 518, E(): 6e-27, (45.3% identity in 159 aa overlap); etc. BELONGS TO THE PPASE FAMILY. COFACTOR: REQUIRES THE PRESENCE OF DIVALENT METAL CATION. MAGNESIUM CONFERS THE HIGHEST ACTIVITY. BINDS 4 DIVALENT CATIONS PER SUBUNIT (BY SIMILARITY). X2BP74,P65747 No intermediary metabolism and respiration Rv3628 NC_002945.3 Mycobrowser_v2 CDS 4005194 4006291 . - 0 Mb3653c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3653c, -, len: 365 aa. Equivalent to Rv3629c,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 365 aa overlap). Probable conserved integral membrane protein, equivalent to O69543|MLCB2548.26|ML0205 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (356 aa), FASTA scores: opt: 1547,E(): 3e-89, (66.2% identity in 361 aa overlap). Also similar to other membrane and hypothetical proteins e.g. CAC37534|SCIF3.15c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (363 aa), FASTA scores: opt: 819,E(): 7.7e-44, (51.55% identity in 351 aa overlap); Q9CGK3|YKJK HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (339 aa) FASTA scores: opt: 683, E(): 2.2e-35, (48.3% identity in 350 aa overlap); Q9KY24|SCC8A.24c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (380 aa) FASTA scores: opt: 528, E(): 1.1e-25, (50.25% identity in 372 aa overlap); Q9RJH8|SCF73.09 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (370 aa) FASTA scores: opt: 439, E(): 3.9e-20, (50.2% identity in 384 aa overlap); Q9PE36|XF1192 INTEGRAL MEMBRANE PROTEIN from Xylella fastidiosa (341 aa), FASTA scores: opt: 337, E(): 8.3e-14, (47.65% identity in 361 aa overlap); etc. Q7TW30 No cell wall and cell processes Rv3629c NC_002945.3 Mycobrowser_v2 CDS 4006412 4007707 . + 0 Mb3654 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3654, -, len: 431 aa. Equivalent to Rv3630, len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 431 aa overlap). Probable conserved integral membrane, highly similar to P71789|YF10_MYCTU|Rv1510|MTCY277.32 HYPOTHETICAL 44.3 KDA PROTEIN from Mycobacterium tuberculosis (432 aa) FASTA scores: opt: 1940, E(): 2.3e-103, (70.75% identity in 424 aa overlap). Note that N-terminal end is highly similar to AAK45825|MT1558 HYPOTHETICAL 18.1 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (172 aa) FASTA scores: opt: 649, E(): 4.2e-30, (61.65% identity in 167 aa overlap); and C-terminal end is highly similar to AAK45826|MT1560 HYPOTHETICAL 25.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 1269, E(): 2.6e-65, (76.7% identity in 253 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, so could be a protease. X2BPF4,P59985 No cell wall and cell processes Rv3630 NC_002945.3 Mycobrowser_v2 CDS 4007751 4008476 . + 0 Mb3655 possible transferase (possibly glycosyltransferase) Mb3655, -, len: 241 aa. Equivalent to Rv3631, len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Possible transferase (EC 2.-.-.-), more specifically a glycosyltransferase (EC 2.4.-.-), equivalent to O69542|MLCB2548.24c|ML0207 PUTATIVE TRANSFERASE (PUTATIVE GLYCOSYLTRANSFERASE) from Mycobacterium leprae (239 aa) FASTA scores: opt: 1303,E(): 2.8e-72, (81.2% identity in 239 aa overlap). Also similar to many dolichyl-phosphate mannose synthases and hypothetical proteins e.g. O59263|PH1585 HYPOTHETICAL 34.6 KDA PROTEIN from Pyrococcus horikoshii (313 aa), FASTA scores: opt: 472, E(): 1.2e-21, (36.65% identity in 232 aa overlap); Q9V152|PAB1971 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE from Pyrococcus abyssi (287 aa), FASTA scores: opt: 467, E(): 2.3e-21, (35.85% identity in 223 aa overlap); Q58619|YC22_METJA|MJ1222 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (243 aa), FASTA scores: opt: 400, E(): 2.4e-17, (33.35% identity in 228 aa overlap); O26474|MTH374 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED PROTEIN from Methanobacterium thermoautotrophicum (291 aa) FASTA scores: opt: 354, E(): 1.7e-14, (33.5% identity in 218 aa overlap); O26239|MTH136 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE from Methanobacterium thermoautotrophicum (220 aa), FASTA scores: opt: 345, E(): 4.8e-14, (33.5% identity in 221 aa overlap); etc. Q7TW29 No intermediary metabolism and respiration Rv3631 NC_002945.3 Mycobrowser_v2 CDS 4008473 4008817 . + 0 Mb3656 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb3656, -, len: 114 aa. Equivalent to Rv3632, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Possible conserved membrane protein, equivalent to O69541|MLCB2548.23c|ML0208 HYPOTHETICAL 12.9 KDA PROTEIN (PUTATIVE MEMBRANE PROTEIN) from Mycobacterium leprae (113 aa), FASTA scores: opt: 594, E(): 7.1e-35, (82.0% identity in 111 aa overlap). Q7TW28 No cell wall and cell processes Rv3632 NC_002945.3 Mycobrowser_v2 CDS 4009028 4009903 . + 0 Mb3657 conserved protein Mb3657, -, len: 291 aa. Equivalent to Rv3633, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Conserved hypothetical protein, similar to Q9X5S6|MMCH from Streptomyces lavendulae (254 aa), FASTA scores: opt: 368,E(): 3.2e-16, (35.05% identity in 194 aa overlap); Q9APW1 HYPOTHETICAL 32.7 KDA PROTEIN from Pseudomonas aeruginosa (295 aa), FASTA scores: opt: 359, E(): 1.3e-15, (37.65% identity in 170 aa overlap); Q9APV4 HYPOTHETICAL 34.1 KDA PROTEIN from Pseudomonas aeruginosa (309 aa), FASTA scores: opt: 316, E(): 7.6e-13, (28.65% identity in 262 aa overlap). And some similarity to Q9HGD7|FUM9 FUM9P from Gibberella moniliformis (300 aa), FASTA scores: opt: 254,E(): 6.5e-09, (29.95% identity in 157 aa overlap); and P47181|YJ9S_YEAST|YJR154W|J2240 HYPOTHETICAL 39.0 KDA PROTEIN from Saccharomyces cerevisiae (Baker's yeast) (346 aa), FASTA scores: opt: 190, E(): 8.5e-05, (26.75% identity in 127 aa overlap). Also similar to P71782|YF01_MYCTU|Rv1501|MT1550|MTCY277.23 from Mycobacterium tuberculosis (273 aa), FASTA scores: opt: 286, E(): 5.5e-11, (27.5% identity in 280 aa overlap). X2BP77 No conserved hypotheticals Rv3633 NC_002945.3 Mycobrowser_v2 CDS 4018753 4019958 . - 0 Mb3668c possible dna polymerase Mb3668c, -, len: 401 aa. Equivalent to Rv3644c,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Possible DNA polymerase (EC 2.7.7.-), equivalent to O69546|MLCB2548.29c|ML0202 HYPOTHETICAL 42.7 KDA PROTEIN from Mycobacterium leprae (405 aa), FASTA scores: opt: 2180, E(): 6.1e-116, (84.4% identity in 404 aa overlap). Similar (in totality or in first 200 aa) to DNA polymerases III, delta' or gamma subunit, e.g. Q9X906|SCH5.03c PUTATIVE DNA POLYMERASE from Streptomyces coelicolor (401 aa), FASTA scores: opt: 1022, E(): 1.5e-50, (47.05% identity in 404 aa overlap); Q9RRS5|DR2410 DNA POLYMERASE III, TAU/GAMMA SUBUNIT from Deinococcus radiodurans (615 aa), FASTA scores: opt: 370,E(): 1.3e-13, (29.95% identity in 394 aa overlap); P28631|HOLB_ECOLI|B1099 DNA POLYMERASE III, DELTA' SUBUNIT from Escherichia coli strain K12 (334 aa), FASTA scores: opt: 345, E(): 2.2e-12, (33.45% identity in 239 aa overlap); Q9JTS1|DNAZX|NMA1656 DNA POLYMERASE III TAU AND GAMMA CHAINS from Neisseria meningitidis (serogroup A) (709 aa), FASTA scores: opt: 346, E(): 3.3e-12, (28.55% identity in 364 aa overlap); etc. Q7TW17 No information pathways Rv3644c NC_002945.3 Mycobrowser_v2 CDS 4009904 4010848 . - 0 Mb3658c galE1 UDP-GLUCOSE 4-EPIMERASE GALE1 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE) Mb3658c, galE1, len: 314 aa. Equivalent to Rv3634c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). galE1, UDP-glucose 4-epimerase (EC 5.1.3.2) (see citations below), equivalent to O69544|ML0204|RMLB2|MLCB2548.27c PUTATIVE SUGAR DEHYDRATASE (PUTATIVE SUGAR-NUCLEOTIDE DEHYDRATASE) from Mycobacterium leprae (319 aa), FASTA scores: opt: 1798,E(): 8.2e-100, (86.4% identity in 309 aa overlap). Also similar to other UDP-GLUCOSE 4-EPIMERASES e.g. Q9WYX9|TM0509 from Thermotoga maritima (309 aa) FASTA scores: opt: 877, E(): 4.8e-45, (45.8% identity in 308 aa overlap); Q57664|GALE_METJA|MJ0211 from Methanococcus jannaschii (305 aa), FASTA scores: opt: 792, E(): 5.4e-40,(42.05% identity in 309 aa overlap); Q9K6S7|BH3649 from Bacillus halodurans (311 aa), FASTA scores: opt: 723, E(): 7e-36, (40.5% identity in 316 aa overlap); Q9HSV1|GALE2|VNG0063G from Halobacterium sp. strain NRC-1 (328 aa), FASTA scores: opt: 597, E(): 2.3e-28, (36.35% identity in 322 aa overlap); etc. Contains short-chain alcohol dehydrogenase family signature (PS00061) but this maynot be significant. BELONGS TO THE SUGAR EPIMERASE FAMILY. Note that previously known as rmlB2, a DTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (see third citation). Q7TW27 No NC_002945.3 Mycobrowser_v2 CDS 4010871 4012646 . + 0 Mb3659 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3659, -, len: 591 aa. Equivalent to Rv3635, len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 591 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 25 aa, to O69545|ML0203|MLCB2548.28 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (569 aa), FASTA scores: opt: 2933,E(): 4.6e-173, (77.0% identity in 569 aa overlap). Q7TW26 No cell wall and cell processes Rv3635 NC_002945.3 Mycobrowser_v2 CDS 4012989 4013336 . + 0 Mb3660 possible transposase Mb3660, -, len: 115 aa. Equivalent to Rv3636, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Possible transposase,weakly similar to others e.g. O69924|SC3C8.12 PUTATIVE TRANSPOSASE from Streptomyces coelicolor (487 aa) FASTA scores: opt: 132, E(): 0.12, (33.05% identity in 112 aa overlap); O96916 TC1-LIKE TRANSPOSASE from Anopheles gambiae (African malaria mosquito) (332 aa), FASTA scores: opt: 117, E(): 0.84, (30.75% identity in 91 aa overlap); Q9R2U5|IS466A|IS466A-ORF|TNPA|IS469|SCP1.276 TRANSPOSASE (INSERTION ELEMENT IS466S TRANSPOSASE) from Streptomyces coelicolor (513 aa), FASTA scores: opt: 114, E(): 2,(30.5% identity in 82 aa overlap); etc. Similar in part to P96288|Rv2943|MTCY24G1.06c HYPOTHETICAL 45.8 KDA PROTEIN from Mycobacterium tuberculosis (413 aa), FASTA scores: opt: 533, E(): 1.4e-28, (74.55% identity in 110 aa overlap). Contains possible helix-turn-helix motif from aa 19-40 (+4.98 SD). Q7TW25 No insertion seqs and phages Rv3636 NC_002945.3 Mycobrowser_v2 CDS 4013721 4014221 . + 0 Mb3661 possible transposase Mb3661, -, len: 166 aa. Equivalent to Rv3637, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Possible transposase. C-terminal end highly similar to Q9RLQ9|ISTA PUTATIVE TRANSPOSASE A (FRAGMENT) from Mycobacterium bovis (102 aa), FASTA scores: opt: 397, E(): 1.4e-19, (58.8% identity in 102 aa overlap). Weakly similar to others e.g. Q9KJ02 PUTATIVE TRANSPOSASE (FRAGMENT) from Polyangium cellulosum (329 aa), FASTA scores: opt: 191, E(): 1.6e-05, (32.1% identity in 134 aa overlap); Q9LCU2|ISTA COINTEGRASE from Pseudomonas aeruginosa (382 aa) FASTA scores: opt: 144,E(): 0.024, (26.8% identity in 123 aa overlap); P15025|ISTA_PSEAE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS21 from Pseudomonas aeruginosa (390 aa), FASTA scores: opt: 144, E(): 0.025, (26.85% identity in 123 aa overlap); etc. Also highly similar to C-terminal end of P96288|Rv2943|MTCY24G1.06c HYPOTHETICAL 45.8 KDA PROTEIN from Mycobacterium tuberculosis (413 aa) FASTA scores: opt: 722, E(): 1.5e-40, (63.7% identity in 168 aa overlap). Q7TW24 No insertion seqs and phages Rv3637 NC_002945.3 Mycobrowser_v2 CDS 4014221 4014967 . + 0 Mb3662 possible transposase Mb3662, -, len: 248 aa. Equivalent to Rv3638, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Possible transposase,highly similar to Q9RLQ8|ISTB ISTB PROTEIN from Mycobacterium bovis (266 aa), FASTA scores: opt: 784, E(): 4e-46, (78.0% identity in 259 aa overlap); and similar to others e.g. P15026|ISTB_PSEAE INSERTION SEQUENCE IS21 PUTATIVE ATP-BINDING PROTEIN from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 420, E(): 2.2e-21, (38.8% identity in 255 aa overlap); Q45619|ISTB_BACST INSERTION SEQUENCE IS5376 PUTATIVE ATP-BINDING PROTEIN from Bacillus stearothermophilus (251 aa), FASTA scores: opt: 402, E(): 3.6e-20, (34.5% identity in 232 aa overlap); P15026|ISTB_ECOLI ISTB PROTEIN from Escherichia coli (265 aa), FASTA scores: opt: 419, E(): 8e-23, (38.8% identity in 255 aa overlap); etc. C-terminus highly similar to C-terminus of P96287|Rv2944|MTCY24G1.05 HYPOTHETICAL 25.5 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (alias AAK47343|MT3016 IS1533, ORFB from Mycobacterium tuberculosis strain CDC1551) (238 aa), FASTA scores: opt: 784, E(): 3.6e-46, (87.4% identity in 135 aa overlap). Q7TW23 No insertion seqs and phages Rv3638 NC_002945.3 Mycobrowser_v2 CDS 4015121 4015687 . - 0 Mb3663c CONSERVED HYPOTHETICAL PROTEIN Mb3663c, -, len: 188 aa. Equivalent to Rv3639c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 188 aa overlap). Hypothetical protein,with C-terminus highly similar to N-terminus of P95044|Rv0698|MTCY210.15 HYPOTHETICAL 22.3 KDA PROTEIN from Mycobacterium tuberculosis (203 aa), FASTA scores: opt: 224, E(): 4.5e-07, (54.8% identity in 73 aa overlap). Q7TW22 No conserved hypotheticals Rv3639c NC_002945.3 Mycobrowser_v2 CDS 4041022 4041822 . - 0 Mb3688c dppC PROBABLE DIPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DPPC Mb3688c, dppC, len: 266 aa. Equivalent to Rv3664c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable dppC,dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F351|SC9E12.04 PUTATIVE PEPTIDE TRANSPORT SYSTEM INTEGRAL MEMBRANE from Streptomyces coelicolor (305 aa), FASTA scores: opt: 901, E(): 1.1e-47,(51.15% identity in 262 aa overlap); Q9KFX1|APPC|BH0349 OLIGOPEPTIDE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (305 aa), FASTA scores: opt: 652, E(): 1.5e-32,(35.55% identity in 270 aa overlap); P94312|DPPC_BACFI DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus firmus (304 aa), FASTA scores: opt: 642, E(): 5.9e-32,(35.75% identity in 263 aa overlap); P24139|OPPC_BACSU|SPO0KC OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (305 aa), FASTA scores: opt: 637, E(): 1.2e-31, (37.4% identity in 262 aa overlap); P26904|DPPC_BACSU|DCIAC DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (320 aa),FASTA scores: opt: 621, E(): 1.2e-30, (39.9% identity in 263 aa overlap); etc. HAS SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS. BELONGS TO THE OPPBC SUBFAMILY. Q7TVZ9 No NC_002945.3 Mycobrowser_v2 CDS 4015757 4016986 . - 0 Mb3664c probable transposase Mb3664c, -, len: 409 aa. Equivalent to Rv3640c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 409 aa overlap). Probable transposase,highly similar to others e.g. Q48882 TRANSPOSASE from Mycobacterium avium (411 aa) FASTA scores: opt: 1574, E(): 6.2e-93, (59.75% identity in 400 aa overlap); Q9AKV5 PUTATIVE TRANSPOSASE (FRAGMENT) from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 1566, E(): 1.9e-92, (60.0% identity in 395 aa overlap); Q48368 TRANSPOSASE from Mycobacterium avium (410 aa), FASTA scores: opt: 1561, E(): 4.1e-92, (59.4% identity in 404 aa overlap); etc. Q7TW21 No insertion seqs and phages Rv3640c NC_002945.3 Mycobrowser_v2 CDS 4017162 4017797 . - 0 Mb3665c fic POSSIBLE CELL FILAMENTATION PROTEIN FIC Mb3665c, fic, len: 211 aa. Equivalent to Rv3641c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Possible fic, cell filamentation protein, similar to others e.g. Q9PCU8|XF1657 CELL FILAMENTATION PROTEIN from Xylella fastidiosa (203 aa), FASTA scores: opt: 324, E(): 2.2e-14,(32.8% identity in 189 aa overlap); P20605|FIC_ECOLI|B3361 from Escherichia coli strain K12 (200 aa), FASTA scores: opt: 323, E(): 2.5e-14, (31.0% identity in 187 aa overlap); P20751|FIC_SALTY from Salmonella typhimurium (200 aa), FASTA scores: opt: 322, E(): 2.9e-14, (32.65% identity in 193 aa overlap); etc. Q7TW20 No NC_002945.3 Mycobrowser_v2 CDS 4020044 4021693 . + 0 Mb3669 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3669, -, len: 549 aa. Equivalent to Rv3645, len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 549 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 20 aa, to O69547|ML0201|MLCB2548.30 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (530 aa), FASTA scores: opt: 2958,E(): 1.5e-168, (85.5% identity in 530 aa overlap). Also closely related to several other hypothetical M. tuberculosis proteins, e.g. Q10631|YD18_MYCTU|Rv1318c|MT1359|MTCY130.03c (541 aa) FASTA scores: opt: 1105, E(): 2.7e-58, (39.35% identity in 506 aa overlap); Q10633|YD20_MYCTU|Rv1320c|MT1362|MTCY130.05c (567 aa) FASTA scores: opt: 1031, E(): 7.1e-54, (38.1% identity in 509 aa overlap); Q10632|YD19_MYCTU|Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 1016, E(): 5.3e-53, (37.1% identity in 531 aa overlap); etc. Also similar at C-terminal end to many adenylate cyclases (EC 4.6.1.1) e.g. O83498|TP0485 from Treponema pallidum (614 aa) FASTA scores: opt: 365, E(): 3.2e-14, (31.55% identity in 317 aa overlap); P94180|CYAA from Anabaena sp. strain PCC 7120 (735 aa), FASTA scores: opt: 364, E(): 4.2e-14, (32.75% identity in 229 aa overlap); etc. Q7TW16 No cell wall and cell processes Rv3645 NC_002945.3 Mycobrowser_v2 CDS 4021690 4024494 . - 0 Mb3670c topA dna topoisomerase i topa (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type i dna topoisomerase) (nicking-closing enzyme) (topo i) Mb3670c, topA, len: 934 aa. Equivalent to Rv3646c,len: 934 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 934 aa overlap). topA, DNA topoisomerase I (EC 5.99.1.2) (see citation below),equivalent to O69548|TOP1_MYCLE|TOPA|ML0200|MLCB2548.31c DNA TOPOISOMERASE I from Mycobacterium leprae (947 aa) FASTA scores: opt: 5150, E(): 0, (84.6% identity in 936 aa overlap). Also highly similar to many e.g. Q9X909|TOP1_STRCO|TOPA|SCH5.06c from Streptomyces coelicolor (952 aa), FASTA scores: opt: 2754, E(): 1.3e-153, (61.3% identity in 928 aa overlap); P73810|TOP1_SYNY3|TOPA|SLR2058 from Synechocystis sp. strain PCC 6803 (898 aa), FASTA scores: opt: 1442, E(): 9.1e-77, (47.15% identity in 927 aa overlap); P47368|TOP1_MYCGE|TOPA|MG122 from Mycoplasma genitalium (709 aa), FASTA scores: opt: 865, E(): 4.8e-43, (30.3% identity in 736 aa overlap); P06612|TOP1_ECOLI|TOPA|SUPX|B1274 from Escherichia coli strain K12 (865 aa), FASTA scores: opt: 397, E(): 0,(39.6% identity in 704 aa overlap); etc. BELONGS TO PROKARYOTIC TYPE I/III TOPOISOMERASE FAMILY. X2BPY1,P0A621 No NC_002945.3 Mycobrowser_v2 CDS 4024847 4025425 . - 0 Mb3671c CONSERVED HYPOTHETICAL PROTEIN Mb3671c, -, len: 192 aa. Equivalent to Rv3647c,len: 192 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 192 aa overlap). Hypothetical protein,equivalent to O69549|MLCB2548.32c|ML0199 HYPOTHETICAL 21.2 KDA PROTEIN from Mycobacterium leprae (200 aa), FASTA scores: opt: 1029, E(): 9e-58, (80.4% identity in 199 aa overlap). Q7TW15 No conserved hypotheticals Rv3647c NC_002945.3 Mycobrowser_v2 CDS 4025565 4025768 . - 0 Mb3672c cspA PROBABLE COLD SHOCK PROTEIN A CSPA Mb3672c, cspA, len: 67 aa. Equivalent to Rv3648c,len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable cspA, cold shock protein A, identical to O69550|CSPB|CSPA|ML0198 SMALL COLD-SHOCK PROTEIN from Mycobacterium leprae (67 aa) FASTA scores: opt: 451, E(): 3.7e-27, (97.0% identity in 67 aa overlap). Also highly similar to many e.g. Q9KGW0|CSPA from Mycobacterium smegmatis (67 aa) FASTA scores: opt: 439, E(): 2.9e-26, (92.55% identity in 67 aa overlap); P54584|CSP_ARTGO from Arthrobacter globiformis (67 aa), FASTA scores: opt: 335, E(): 1.5e-18, (73.45% identity in 64 aa overlap); O30875|CSPA_MICLU from Micrococcus luteus (Micrococcus lysodeikticus); Q9Z5R4|CSPA_BORPE from Bordetella pertussis (67 aa) FASTA scores: opt: 294, E(): 1.7e-15, (59.7% identity in 67 aa overlap); etc. Contains 'cold-shock' DNA-binding domain signature (PS00352) at N-terminal end. BELONGS TO THE COLD-SHOCK DOMAIN (CSD) FAMILY. X2BP88,P63849 No NC_002945.3 Mycobrowser_v2 CDS 4038612 4039382 . - 0 Mb3686c CONSERVED HYPOTHETICAL PROTEIN Mb3686c, -, len: 256 aa. Equivalent to Rv3662c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 256 aa overlap). Conserved hypothetical protein, equivalent to Q9CB99|ML2289 HYPOTHETICAL PROTEIN from Mycobacterium leprae (256 aa) FASTA scores: opt: 1255, E(): 3.3e-69, (78.05% identity in 255 aa overlap). Also similar to Q9X924|SCH5.22c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (274 aa), FASTA scores: opt: 289, E(): 1.8e-10, (39.25% identity in 270 aa overlap). Q7TW01 No conserved hypotheticals Rv3662c NC_002945.3 Mycobrowser_v2 CDS 4039379 4041025 . - 0 Mb3687c dppD PROBABLE DIPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DPPD Mb3687c, dppD, len: 548 aa. Equivalent to Rv3663c,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 548 aa overlap). Probable dppD,dipeptide-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. AAK65441|SMA1434 PROBABLE ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (550 aa), FASTA scores: opt: 1528, E(): 1e-78, (46.25% identity in 545 aa overlap); O50270|MOAD MOAD PROTEIN from Agrobacterium radiobacter (588 aa),FASTA scores: opt: 1354, E(): 6.7e-69, (42.9% identity in 541 aa overlap); Q9KM01|VCA0588 PUTATIVE PEPTIDE ABC TRANSPORTER ATP-BINDING PROTEIN from Vibrio cholerae (530 aa), FASTA scores: opt: 951, E(): 3.1e-46, (44.0% identity in 534 aa overlap); BAB49448|MLR2279 ATP-BINDING PROTEIN OF PEPTIDE ABC TRANSPORTER from Rhizobium loti (Mesorhizobium loti) (604 aa), FASTA scores: opt: 949,E(): 4.4e-46, (41.55% identity in 544 aa overlap); etc. Contains 2 PS00211 ABC transporters family signature, and 2 PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TW00 No NC_002945.3 Mycobrowser_v2 CDS 4026018 4028333 . + 0 Mb3673 probable helicase Mb3673, -, len: 771 aa. Equivalent to Rv3649, len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 771 aa overlap). Probable helicase (EC 3.6.-.-), similar to many (known or hypothetical) ATP-dependent helicases e.g. Q9X915|SCH5.13 PUTATIVE HELICASE from Streptomyces coelicolor (815 aa) FASTA scores: opt: 2550, E(): 9.6e-139, (52.45% identity in 774 aa overlap); Q05549|YDR291W|D9819.1 PROTEIN SIMILAR TO SEVERAL DNA HELICASES from Saccharomyces cerevisiae (Baker's yeast) (1077 aa), FASTA scores: opt: 1161, E(): 5.9e-59, (31.05% identity in 780 aa overlap); P50830|YPRA_BACSU HYPOTHETICAL HELICASE from Bacillus subtilis (749 aa), FASTA scores: opt: 1154, E(): 1.1e-58,(34.05% identity in 734 aa overlap); Q9KC10|BH1764 ATP-DEPENDENT RNA HELICASE from Bacillus halodurans (764 aa), FASTA scores: opt: 1122, E(): 8e-57, (32.3% identity in 759 aa overlap); etc. SEEMS SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY, AND TO HELICASE C-TERMINAL DOMAIN. Q7TW14 No information pathways Rv3649 NC_002945.3 Mycobrowser_v2 CDS 4028470 4028754 . + 0 Mb3674 PE33 pe family protein pe33 Mb3674, PE33, len: 94 aa. Equivalent to Rv3650,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Short protein, member of the Mycobacterium tuberculosis PE family, but without the repetitive gly-rich region, similar to the N-terminal part of many e.g. O53809|Rv0746|MTV041.20 PGRS-FAMILY PROTEIN (783 aa), FASTA scores: opt: 363, E(): 2.1e-15,(76.55% identity in 81 aa overlap). Q7TW13 No PE/PPE Rv3650 NC_002945.3 Mycobrowser_v2 CDS 4034282 4035340 . - 0 Mb3683c CONSERVED HYPOTHETICAL PROTEIN Mb3683c, -, len: 352 aa. Equivalent to Rv3659c,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein, highly similar, but always shorter (various lengths) at N-terminus, to Q9X921|SCH5.19c PUTATIVE SECRETORY PROTEIN from Streptomyces coelicolor (523 aa), FASTA scores: opt: 1287, E(): 5.3e-66, (59.85% identity in 351 aa overlap); Q9HW98|PA4302 PROBABLE TYPE II SECRETION SYSTEM PROTEIN from Pseudomonas aeruginosa (421 aa), FASTA scores: opt: 776, E(): 5.4e-37, (42.8% identity in 320 aa overlap); AAK65510|CPAF2 PROBABLE CPAF2 PILUS ASSEMBLY PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (497 aa) FASTA scores: opt: 769, E(): 1.5e-36, (40.45% identity in 309 aa overlap); Q9KY93|SCK15.11 PUTATIVE SECRETORY PROTEIN from Streptomyces coelicolor (445 aa), FASTA scores: opt: 751,E(): 1.5e-35, (38.15% identity in 333 aa overlap); etc. Contains PS00017 ATP/GTP binding site motif A (P-loop). Note that previously known as trbB. Q7TW04 No conserved hypotheticals Rv3659c NC_002945.3 Mycobrowser_v2 CDS 4035442 4036494 . - 0 Mb3684c CONSERVED HYPOTHETICAL PROTEIN Mb3684c, -, len: 350 aa. Equivalent to Rv3660c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 350 aa overlap). Conserved hypothetical protein, similar to O33612 PROTEIN CONCERNED IN INHIBITION OF MORPHOLOGICAL DIFFERENTIATION IN Streptomyces azureus from Streptomyces cyaneus (Streptomyces curacoi) (370 aa),FASTA scores: opt: 655, E(): 5.9e-31, (42.2% identity in 315 aa overlap); Q9X922|SCH5.20c PUTATIVE SEPTUM SITE DETERMINING PROTEIN from Streptomyces coelicolor (396 aa),FASTA scores: opt: 592, E(): 2.9e-27, (43.25% identity in 275 aa overlap). And shows some similarity to AAK65513|CPAE2 PROBABLE CPAE2 PILUS ASSEMBLY PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (586 aa) FASTA scores: opt: 212, E(): 5.1e-05, (25.75% identity in 295 aa overlap); and several cell division inhibitors or septum site-determining proteins. Equivalent to AAK48124 from Mycobacterium tuberculosis strain CDC1551 (261 aa) but longer 89 aa. Q7TW03 No virulence, detoxification, adaptation Rv3660c NC_002945.3 Mycobrowser_v2 CDS 4036994 4037857 . + 0 Mb3685 CONSERVED HYPOTHETICAL PROTEIN Mb3685, -, len: 287 aa. Equivalent to Rv3661, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). Conserved hypothetical protein, highly similar to O33611|IMD_STRCN from Streptomyces cyaneus (Streptomyces curacoi) protein involved in inhibition of morphological differentiation in Streptomyces azureus (BELONGS TO THE SERB FAMILY) (277 aa) FASTA scores: opt: 1073, E(): 3.5e-61, (61.45% identity in 262 aa overlap); and Q9X923|SCH5.21 PUTATIVE MORPHOLOGICAL DIFFERENTIATION-ASSOCIATED PROTEIN from Streptomyces coelicolor (268 aa), FASTA scores: opt: 1057, E(): 3.6e-60, (61.45% identity in 262 aa overlap). Also similar to various bacterial proteins (principally serB-related proteins) e.g. Q49823|ML2424 HYPOTHETICAL SERB PROTEIN from Mycobacterium leprae (300 aa), FASTA scores: opt: 452, E(): 1.4e-21, (35.8% identity in 257 aa overlap); Q9WX12|SCE68.20 HYPOTHETICAL 32.0 KDA PROTEIN from Streptomyces coelicolor (298 aa), FASTA scores: opt: 415,E(): 3.1e-19, (33.55% identity in 280 aa overlap); Q9RIT2|SERB PHOSPHOSERINE PHOSPHATASE (FRAGMENT) from Streptomyces coelicolor (266 aa), FASTA scores: opt: 405,E(): 1.2e-18, (34.1% identity in 261 aa overlap); etc. Also similar to Q11169|Y505_MYCTU|Rv0505c|MTCY20G9.32c HYPOTHETICAL 39.5 KDA PROTEIN from Mycobacterium tuberculosis (373 aa), FASTA scores: opt: 454, E(): 1.2e-21, (35.15% identity in 276 aa overlap). BELONGS TO THE SERB FAMILY. Q7TW02 No virulence, detoxification, adaptation Rv3661 NC_002945.3 Mycobrowser_v2 CDS 4041878 4042804 . - 0 Mb3689c dppB PROBABLE DIPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DPPB Mb3689c, dppB, len: 308 aa. Equivalent to Rv3665c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable dppB,dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F352|SC9E12.03 PUTATIVE PEPTIDE TRANSPORT SYSTEM INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (307 aa), FASTA scores: opt: 1145,E(): 1.8e-61, (57.65% identity in 307 aa overlap); Q53191|Y4TP_RHISN PROBABLE PEPTIDE ABC TRANSPORTER PERMEASE PROTEIN Rhizobium sp. strain NGR234 (313 aa),FASTA scores: opt: 653, E(): 5.2e-32, (31.2% identity in 314 aa overlap); P24138|OPPB_BACSU OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE from Bacillus subtilis (311 aa), FASTA scores: opt: 643, E(): 2.1e-31, (33.45% identity in 305 aa overlap); etc. BELONGS TO THE OPPBC SUBFAMILY. Q7TVZ8 No NC_002945.3 Mycobrowser_v2 CDS 4042806 4044431 . - 0 Mb3690c dppA PROBABLE PERIPLASMIC DIPEPTIDE-BINDING LIPOPROTEIN DPPA Mb3690c, dppA, len: 541 aa. Equivalent to Rv3666c,len: 541 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 541 aa overlap). Probable dppA,dipeptide-binding lipoprotein component of dipeptide transport system (see citation below), similar to many substrate-binding proteins e.g. Q9F353|SC9E12.02 PUTATIVE PEPTIDE TRANSPORT SYSTEM SECRETED PEPTIDE-BINDING PROTEIN from Streptomyces coelicolor (544 aa), FASTA scores: opt: 1200, E(): 9e-67, (39.2% identity in 538 aa overlap); P24141|OPPA_BACSU OLIGOPEPTIDE-BINDING PROTEIN from Bacillus subtilis (545 aa), FASTA scores: opt: 523, E(): 7.9e-25, (26.15% identity in 516 aa overlap); P23843|OPPA_ECOLI PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN from Escherichia coli (543 aa), FASTA scores: opt: 452,E(): 2e-20, (25.9% identity in 529 aa overlap); etc. Contains probable N-terminal signal sequence. Q7TVZ7 No NC_002945.3 Mycobrowser_v2 CDS 4066098 4066430 . - 0 Mb3711c CONSERVED HYPOTHETICAL PROTEIN Mb3711c, -, len: 110 aa. Equivalent to Rv3686c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Hypothetical protein,similar to P96893|Rv3288c|MTCY71.28c HYPOTHETICAL 15.2 KDA PROTEIN from Mycobacterium tuberculosis (and Mycobacterium bovis) (137 aa) FASTA scores: opt: 106, E(): 5.6, (29.1% identity in 79 aa overlap); and a few hypothetical proteins e.g. Q9GUV6|L2259.2 from Leishmania major (360 aa) FASTA scores: opt: 118, E(): 2.1, (28.7% identity in 101 aa overlap). Equivalent to AAK48155 from Mycobacterium tuberculosis strain CDC1551 (166 aa) but shorter 56 aa. Q7TVX9 No conserved hypotheticals Rv3686c NC_002945.3 Mycobrowser_v2 CDS 4045139 4047094 . + 0 Mb3691 acs ACETYL-COENZYME A SYNTHETASE ACS (ACETATE--CoA LIGASE) (ACETYL-CoA SYNTHETASE) (ACETYL-CoA SYNTHASE) (ACYL-ACTIVATING ENZYME) (ACETATE THIOKINASE) (ACETYL-ACTIVATING ENZYME) (ACETATE--COENZYME A LIGASE) (ACETYL-COENZYME A SYNTHASE) Mb3691, acs, len: 651 aa. Equivalent to Rv3667,len: 651 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 651 aa overlap). Probable acs,acetyl-coenzyme-A synthetase (EC 6.2.1.1), similar to many e.g. Q9X928|SCH5.26 from Streptomyces coelicolor (651 aa) FASTA scores: opt: 2850, E(): 1.9e-164, (66.05% identity in 639 aa overlap); Q55404|ACSA_SYNY3|ACS|SLL0542 from Synechocystis sp. strain PCC 6803 (653 aa), FASTA scores: opt: 2342, E(): 8.8e-134, (55.15% identity in 649 aa overlap); P31638|ACSA_ALCEU|ACOE from Alcaligenes eutrophus (Ralstonia eutropha) (660 aa), FASTA scores: opt: 2181, E(): 4.6e-124, (52.05% identity in 665 aa overlap); P27550|ACSA_ECOLI|ACS|B4069 from Escherichia coli strain K12 (652 aa), FASTA scores: opt: 1625, E(): 0,(48.3% identity in 646 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. X2BNU6,P59871 No lipid metabolism Rv3667 NC_002945.3 Mycobrowser_v2 CDS 4069865 4070866 . + 0 Mb3716 conserved protein Mb3716, -, len: 333 aa. Equivalent to Rv3691, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 333 aa overlap). Conserved hypothetical protein, similar to Q9KYW4|SCE33.19 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (387 aa) FASTA scores: opt: 481, E(): 6e-23, (36.6% identity in 358 aa overlap). Equivalent to AAK48160 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 48 aa. Q7TVX4 No conserved hypotheticals Rv3691 NC_002945.3 Mycobrowser_v2 CDS 4048174 4048692 . + 0 Mb3693 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3693, -, len: 172 aa. Equivalent to Rv3669, len: 172 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 172 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CB97|ML2296 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 863, E(): 1.4e-47, (77.35% identity in 181 aa overlap). Also similar to two PUTATIVE INTEGRAL MEMBRANE TRANSPORT PROTEINS from Streptomyces coelicolor; Q9X930|SCH5.28 (162 aa) FASTA scores: opt: 265, E(): 6.3e-10, (37.4% identity in 155 aa overlap); and Q9X9W1|SCI7.29c (165 aa), FASTA scores: opt: 194, E(): 1.9e-05, (30.6% identity in 134 aa overlap). Contains two hydrophobic stretches in centre. Q7TVZ5 No cell wall and cell processes Rv3669 NC_002945.3 Mycobrowser_v2 CDS 4048693 4049676 . + 0 Mb3694 ephE POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) Mb3694, ephE, len: 327 aa. Equivalent to Rv3670,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 327 aa overlap). Possible ephE,epoxide hydrolase (EC 3.3.2.3) (see citation below),equivalent to Q9CB96|ML2297 PUTATIVE HYDROLASE from Mycobacterium leprae (324 aa), FASTA scores: opt: 1799,E(): 7.2e-105, (80.55% identity in 324 aa overlap). Also similar to many hydrolases (epoxide hydrolases) and hypothetical proteins e.g. Q9X931|SCH5.29 PUTATIVE HYDROLASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 687, E(): 1.4e-35, (40.65% identity in 327 aa overlap); Q9RRE3|DR2549 EPOXIDE HYDROLASE-RELATED PROTEIN from Deinococcus radiodurans (278 aa), FASTA scores: opt: 321, E(): 8.2e-13, (32.15% identity in 311 aa overlap); Q9K3Q1|2SCG4.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (292 aa), FASTA scores: opt: 295, E(): 3.5e-11,(30.18% identity in 275 aa overlap); Q9S7P1 EPOXIDE HYDROLASE from Oryza sativa (Rice) (322 aa), FASTA scores: opt: 289, E(): 9.1e-11, (28.7% identity in 338 aa overlap); O23227|C7A10.830|AT4G36530 EPOXIDE HYDROLASE from Arabidopsis thaliana (Mouse-ear cress) (378 aa) FASTA scores: opt: 287, E(): 1.4e-10, (26.1% identity in 272 aa overlap); Q21147|K02F3.6 EPOXIDE HYDROLASE from Caenorhabditis elegans (386 aa), FASTA scores: opt: 283,E(): 2.5e-10, (33.35% identity in 156 aa overlap); etc. Also similar to P95276|EPHB|Rv1938|MTCY09F9.26c from Mycobacterium tuberculosis (356 aa), FASTA scores: opt: 296, E(): 3.6e-11, (29.7% identity in 340 aa overlap). Contains PS00213 Lipocalin signature. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. Q7TVZ4 No virulence, detoxification, adaptation Rv3670 NC_002945.3 Mycobrowser_v2 CDS 4077587 4077811 . - 0 Mb3723A vapB48 Possible antitoxin VapB48 Mb3723A, len: 74 aa. Equivalent to Rv3697A len: 74 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB48,antitoxin,part of toxin-antitoxin (TA) operon with Rv3697c, see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. Rv3321c, Rv0748 X2BPK9 No virulence, detoxification, adaptation Rv3697A NC_002945.3 Mycobrowser_v2 CDS 4049669 4050862 . - 0 Mb3695c membrane-associated serine protease Mb3695c, -, len: 397 aa. Equivalent to Rv3671c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Possible serine protease membrane protein (EC 3.4.21.-), equivalent to Q9CB95|ML2298 PUTATIVE MEMBRANE-ASSOCIATED SERINE PROTEASE from Mycobacterium leprae (401 aa), FASTA scores: opt: 2061, E(): 2.3e-108, (80.9% identity in 398 aa overlap). Also similar to many serine proteases, but generally with extended N-terminus, e.g. Q9X932|SCH5.30c PUTATIVE SERINE PROTEASE (FRAGMENT) from Streptomyces coelicolor (385 aa),FASTA scores: opt: 835, E(): 1.2e-39, (39.9% identity in 386 aa overlap); Q9Z6T0|DEGP_CHLPN|HTRA|CPN0979|CP0877 PROBABLE SERINE PROTEASE DO-LIKE PRECURSOR from Chlamydia pneumoniae (Chlamydophila pneumoniae) (488 aa), FASTA scores: opt: 285, E(): 1e-08, (29.05% identity in 296 aa overlap); P73354|HTRA|SLR1204 SERINE PROTEASE from Synechocystis sp. strain PCC 6803 (452 aa), FASTA scores: opt: 284, E(): 1.1e-08, (29.55% identity in 308 aa overlap); Q9RWC4|DR0745 PERIPLASMIC SERINE PROTEASE,HTRA/DEGQ/DEGS FAMILY from Deinococcus radiodurans (366 aa), FASTA scores: opt: 271, E(): 4.9e-08, (35.45% identity in 206 aa overlap); etc. Also similar, but longer 114 aa at the N-terminus, to Q9S2P8|SC5F7.13 PUTATIVE PEPTIDASE from Streptomyces coelicolor (282 aa), FASTA scores: opt: 594, E(): 3.1e-26, (38.95% identity in 285 aa overlap). And similar, but longer 146 aa at the N-terminus, to O07175|PEPA|Rv0125|MTCI418B.07 from Mycobacterium tuberculosis (355 aa), FASTA scores: opt: 295, E(): 2.2e-09, (29.55% identity in 254 aa overlap); and Q9CCY9|ML2659 PROBABLE SECRETED SERINE PROTEASE from Mycobacterium leprae FASTA scores: opt: 286, E(): 6.9e-09,(30.6% identity in 255 aa overlap). Contains PS00135 Serine proteases, trypsin family, serine active site. Q7TVZ3 No intermediary metabolism and respiration Rv3671c NC_002945.3 Mycobrowser_v2 CDS 4051821 4052504 . - 0 Mb3697c POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) Mb3697c, -, len: 227 aa. Equivalent to Rv3673c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q9CB93|ML2300 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52,(71.15% identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA PROTEIN from Bacillus subtilis (181 aa), FASTA scores: opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa overlap); Q9RXW6|DR0189 THIOL:DISULFIDE INTERCHANGE PROTEIN from Deinococcus radiodurans (185 aa) FASTA scores: opt: 206, E(): 1.3e-05, (33.8% identity in 139 aa overlap); Q9I505|PA0953 PROBABLE THIOREDOXIN from Pseudomonas aeruginosa (154 aa), FASTA scores: opt: 180,E(): 0.00044, (34.85% identity in 109 aa overlap); Q9KCP7|BH1522 THIOREDOXIN (THIOL:DISULFIDE INTERCHANGE PROTEIN) from Bacillus halodurans (177 aa), FASTA scores: opt: 178, E(): 0.00064, (31.75% identity in 107 aa overlap); P43221|TLPA_BRAJA THIOL:DISULFIDE INTERCHANGE PROTEIN (CYTOCHROME C BIOGENESIS PROTEIN) from Bradyrhizobium japonicum (221 aa), FASTA scores: opt: 189,E(): 0.00017, (26.85% identity in 227 aa overlap); etc. Also similar to O06392|Rv0526|MTCY25D10.05 HYPOTHETICAL 23.2 KDA PROTEIN from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 160, E(): 0.0093, (27.45% identity in 142 aa overlap). Contains PS00194 Thioredoxin family active site. POSSIBLY BELONGS TO THE THIOREDOXIN FAMILY. Q7TVZ1 No intermediary metabolism and respiration Rv3673c NC_002945.3 Mycobrowser_v2 CDS 4052504 4053241 . - 0 Mb3698c nth PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC SITE)LYASE) (AP LYASE) (AP ENDONUCLEASE CLASS I) (ENDODEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) (DEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) Mb3698c, nth, len: 245 aa. Equivalent to Rv3674c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Probable nth,endonuclease III (EC 4.2.99.18), equivalent to Q9CB92|NTH|ML2301 PUTATIVE ENDONUCLEASE III from Mycobacterium leprae (272 aa), FASTA scores: opt: 1363,E(): 3.6e-81, (89.4% identity in 226 aa overlap). Also similar to many e.g. Q9XA44|SCH17.03c from Streptomyces coelicolor (250 aa), FASTA scores: opt: 937, E(): 2.2e-55,(61.65% identity in 219 aa overlap); P46303|UVEN_MICLU from Micrococcus luteus (Micrococcus lysodeikticus) (279 aa), FASTA scores: opt: 899, E(): 8.1e-53, (58.45% identity in 248 aa overlap); P73715|END3_SYNY3|NTH|SLR1822 from Synechocystis sp. strain PCC 6803 (219 aa), FASTA scores: opt: 684, E(): 1.7e-38, (52.2% identity in 203 aa overlap); P39788|END3_BACSU|NTH|JOOB from Bacillus subtilis (219 aa), FASTA scores: opt: 552, E(): 1.2e-29,(43.3% identity in 194 aa overlap); etc. Equivalent to AAK48142 from Mycobacterium tuberculosis strain CDC1551 (262 aa) but shorter 17 aa. Contains PS00764 Endonuclease III iron-sulfur binding region signature, and PS01155 Endonuclease III family signature. BELONGS TO THE NTH/MUTY FAMILY. COFACTOR: BINDS A 4FE-4S CLUSTER WHICH IS NOT IMPORTANT FOR THE CATALYTIC ACTIVITY, BUT WHICH IS PROBABLY INVOLVED IN THE PROPER POSITIONING OF THE ENZYME ALONG THE DNA STRAND (BY SIMILARITY). N-terminus extended since first submission (previously 226 aa). X2BP01,P63541 No NC_002945.3 Mycobrowser_v2 CDS 4053349 4053726 . + 0 Mb3699 POSSIBLE MEMBRANE PROTEIN Mb3699, -, len: 125 aa. Equivalent to Rv3675, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Possible membrane protein, with some similarity to Q9YCZ2|APE1120 HYPOTHETICAL 11.7 KDA PROTEIN from Aeropyrum pernix (103 aa), FASTA scores: opt: 100, E(): 9, (40.0% identity in 55 aa overlap). Q7TVZ0 No cell wall and cell processes Rv3675 NC_002945.3 Mycobrowser_v2 CDS 4053825 4054499 . + 0 Mb3700 crp transcriptional regulatory protein crp (crp/fnr-family) Mb3700, -, len: 224 aa. Equivalent to Rv3676, len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable transcriptional regulator belonging to crp/fnr family,identical to Q9CB91|ML2302 PUTATIVE CRP/FNR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (224 aa), FASTA scores: opt: 1408, E(): 8.8e-81, (95.95% identity in 224 aa overlap). Also highly similar to transcriptional regulators AAK58838 from Corynebacterium glutamicum (Brevibacterium flavum) (227 aa), FASTA scores: opt: 1178, E(): 1.9e-66, (79.9% identity in 224 aa overlap); and Q9XA42|SCH17.05 from Streptomyces coelicolor (224 aa), FASTA scores: opt: 869, E(): 3.4e-47, (54.45% identity in 224 aa overlap); and similar to others e.g. Q9RRX0|DR2362 from Deinococcus radiodurans (231 aa) FASTA scores: opt: 344, E(): 1.8e-14, (30.8% identity in 211 aa overlap); P29281|CRP_HAEIN from Haemophilus influenzae (224 aa), FASTA scores: opt: 330, E(): 1.3e-13, (32.25% identity in 189 aa overlap); P03020|CRP_ECOLI|CAP|CSM|B3357 from Escherichia coli strain K12 and Shigella flexneri (210 aa), FASTA scores: opt: 323, E(): 3.5e-13, (32.25% identity in 189 aa overlap); etc. Contains helix-turn-helix motif at aa 175-196 (Score 1990, +5.96 SD). BELONGS TO THE CRP/FNR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TVY9 No regulatory proteins Rv3676 NC_002945.3 Mycobrowser_v2 CDS 4054605 4055399 . - 0 Mb3701c possible hydrolase Mb3701c, -, len: 264 aa. Equivalent to Rv3677c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Possible hydrolase (EC 3.-.-.-), equivalent to Q9CB90|ML2303 PUTATIVE HYDROLASE from Mycobacterium leprae (262 aa) FASTA scores: opt: 1400, E(): 8.5e-81, (82.05% identity in 262 aa overlap). Also similar to other hydrolases and hypothetical proteins e.g. Q9XA41|SCH17.06c PUTATIVE HYDROLASE from Streptomyces coelicolor (256 aa) FASTA scores: opt: 609, E(): 3.9e-31, (54.65% identity in 247 aa overlap); Q9A9Q1|CC0923 METALLO-BETA-LACTAMASE FAMILY PROTEIN from Caulobacter crescentus (297 aa), FASTA scores: opt: 306, E(): 4.7e-12, (35.45% identity in 268 aa overlap); Q9Y392 CGI-83 PROTEIN from Homo sapiens (Human) (288 aa), FASTA scores: opt: 281, E(): 1.7e-10, (33.2% identity in 259 aa overlap); Q9F7R6 PREDICTED METALLOBETA LACTAMASE FOLD PROTEIN from uncultured proteobacterium EBAC31A08 (265 aa), FASTA scores: opt: 257, E(): 5.1e-09,(32.55% identity in 252 aa overlap); Q9PBI4|XF2160 HYDROXYACYLGLUTATHIONE HYDROLASE from Xylella fastidiosa (258 aa), FASTA scores: opt: 232, E(): 1.9e-07, (30.3% identity in 165 aa overlap); etc. Q7TVY8 No intermediary metabolism and respiration Rv3677c NC_002945.3 Mycobrowser_v2 CDS 4064642 4066072 . - 0 Mb3710c cyp137 PROBABLE CYTOCHROME P450 137 CYP137 Mb3710c, cyp137, len: 476 aa. Equivalent to Rv3685c, len: 476 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 476 aa overlap). Probable cyp137, cytochrome P-450 (EC 1.14.-.-), similar to many e.g. Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila melanogaster (Fruit fly) (495 aa), FASTA scores: opt: 376,E(): 1.2e-15, (28.35% identity in 413 aa overlap); Q59163|CYP110A2 from Anabaena variabilis (459 aa) FASTA scores: opt: 320, E(): 3.1e-12, (31.4% identity in 411 aa overlap); O23051|C883_ARATH from Arabidopsis thaliana (Mouse-ear cress) (490 aa), FASTA scores: opt: 313, E(): 8.8e-12, (28.25% identity in 425 aa overlap); etc. Also similar to many from Mycobacterium tuberculosis e.g. O53765|C13B_MYCTU|CYP135B1|Rv0568|MT0594|MTV039.06 (472 aa), FASTA scores: opt: 920, E(): 4.6e-49, (36.25% identity in 447 aa overlap); P96813|C138_MYCTU|CYP138|Rv0136|MT0144|MTCI5.10 (441 aa) FASTA scores: opt: 886, E(): 5.3e-47, (35.5% identity in 445 aa overlap); etc. BELONGS TO THE CYTOCHROME P450 FAMILY. Q7TVY0 No intermediary metabolism and respiration Rv3685c NC_002945.3 Mycobrowser_v2 CDS 4055406 4055861 . - 0 Mb3702c conserved protein Mb3702c, -, len: 151 aa. Equivalent to Rv3678c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, equivalent, but shorter 23 aa, to Q9CB89|ML2304 HYPOTHETICAL PROTEIN from Mycobacterium leprae (174 aa), FASTA scores: opt: 746, E(): 2.1e-40,(78.15% identity in 151 aa overlap). Also highly similar to many hypothetical proteins or transcription regulators e.g. Q9XA38|SCH17.09c from Streptomyces coelicolor (155 aa), FASTA scores: opt: 637, E(): 1.5e-33, (69.1% identity in 152 aa overlap); BAB48205|MLR0658 from Rhizobium loti (Mesorhizobium loti) (154 aa), FASTA scores: opt: 500,E(): 6.8e-25, (55.35% identity in 150 aa overlap); BAB50615|MLR3802 TRANSCRIPTION REGULATOR from Rhizobium loti (Mesorhizobium loti) (153 aa), FASTA scores: opt: 425,E(): 3.8e-20, (44.35% identity in 151 aa overlap); Q9U0W7|L7276.02 from Leishmania major (163 aa) FASTA scores: opt: 404, E(): 8.5e-19, (47.7% identity in 151 aa overlap); Q9UZA3|PAB0825 PUTATIVE TRANSLATION INITIATION INHIBITOR from Pyrococcus abyssi (127 aa), FASTA scores: opt: 108, E(): 3.7, (30.75% identity in 130 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Q7TVY7 No conserved hypotheticals Rv3678c NC_002945.3 Mycobrowser_v2 CDS 4056123 4057145 . + 0 Mb3704 PROBABLE ANION TRANSPORTER ATPASE Mb3704, -, len: 340 aa. Equivalent to Rv3679, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Probable anion transporting ATPase (EC 3.6.1.-), equivalent to Q9CB88|ML2305 PROBABLE ANION TRANSPORTER PROTEIN from Mycobacterium leprae (341 aa), FASTA scores: opt: 1810,E(): 2.1e-98, (84.15% identity in 341 aa overlap). Also highly similar to Q9XA36|SCH17.11 PUTATIVE ION-TRANSPORTING ATPASE from Streptomyces coelicolor (325 aa), FASTA scores: opt: 989, E(): 1.4e-50, (52.15% identity in 328 aa overlap); and similar to many anion transporting ATPases (principally arsenite transporters) e.g. O50593|ARSA_ACIMU ARSENICAL PUMP-DRIVING ATPASE (ARSENITE-TRANSLOCATING ATPASE) from Acidiphilium multivorum (583 aa), FASTA scores: opt: 225, E(): 8.1e-06,(25.1% identity in 319 aa overlap); AAG43231|ARSA ARSENITE ACITVATED ATPASE from Salmonella typhimurium plasmid R46 FASTA scores: opt: 211, E(): 5.3e-05, (26.95% identity in 267 aa overlap); P52145|ARA2_ECOLI|ARSA ARSENICAL PUMP-DRIVING ATPASE from Escherichia coli plasmid IncN R46 (583 aa), FASTA scores: opt: 211, E(): 5.3e-05, (26.95% identity in 267 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SOME SIMILARITY TO THE ARSA ATPASE FAMILY. X2BPJ1,P65090 No cell wall and cell processes Rv3679 NC_002945.3 Mycobrowser_v2 CDS 4057142 4058302 . + 0 Mb3705 PROBABLE ANION TRANSPORTER ATPASE Mb3705, -, len: 386 aa. Equivalent to Rv3680, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Probable anion transporting ATPase (EC 3.6.1.-), equivalent to Q9CB87|ML2306 PROBABLE ANION TRANSPORTER PROTEIN from Mycobacterium leprae (381 aa), FASTA scores: opt: 2131,E(): 6.5e-120, (88.1% identity in 370 aa overlap). Also highly similar, but shorter 29 aa, to Q9XA35|SCH17.12 PUTATIVE ION-TRANSPORTING ATPASE from Streptomyces coelicolor (481 aa), FASTA scores: opt: 1190, E(): 1.1e-63, (51.25% identity in 441 aa overlap); and similar to many anion transporting ATPases e.g. Q9UZA6|PAB1555 ANION TRANSPORTING ATPASE from Pyrococcus abyssi (330 aa) FASTA scores: opt: 242, E(): 3e-07, (24.6% identity in 297 aa overlap); Q9P7F8|SPAC1142.06 PUTATIVE ARSENITE-TRANSLOCATING from Schizosaccharomyces pombe (Fission yeast) (329 aa), FASTA scores: opt: 239, E(): 4.5e-07, (27.9% identity in 197 aa overlap); Q9HS79|ARSA1|VNG0365G ARSENICAL PUMP-DRIVING ATPASE from Halobacterium sp. strain NRC-1 (347 aa), FASTA scores: opt: 238, E(): 5.4e-07, (29.35% identity in 358 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TVY5 No cell wall and cell processes Rv3680 NC_002945.3 Mycobrowser_v2 CDS 4075549 4076529 . - 0 Mb3721c glpKb PROBABLE GLYCEROL KINASE GLPKB [SECOND PART] (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK) Mb3721c, glpKb, len: 326 aa. Equivalent to 3' end of Rv3696c, len: 517 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 326 aa overlap). Probable glpK, glycerol kinase (EC 2.7.1.30), equivalent to Q9CB81|GLPK_MYCLE|ML2314 GLYCEROL KINASE from Mycobacterium leprae (508 aa), FASTA scores: opt: 3120,E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606,E(): 1.1e-156, (75.35% identity in 503 aa overlap); Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503 aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa), FASTA scores: opt: 1838, E(): 2.7e-108,(54.8% identity in 498 aa overlap); P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3% identity in 499 aa overlap); etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1, PS00070 Aldehyde dehydrogenases cysteine active site, PS00445 FGGY family of carbohydrate kinases signature 2. BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, glpK exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g), splits glpK into 2 parts, glpKa and glpKb and removes activity. No NC_002945.3 Mycobrowser_v2 CDS 4077841 4079370 . + 0 Mb3724 conserved protein Mb3724, -, len: 509 aa. Equivalent to Rv3698, len: 509 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 509 aa overlap). Conserved hypothetical protein, highly similar to Q9AK89|SC10A9.15c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (505 aa), FASTA scores: opt: 1720, E(): 9e-103, (53.65% identity in 494 aa overlap). N-terminal end highly similar to CAC42136|SCBAC25F8.01 CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) from Streptomyces coelicolor (291 aa), FASTA scores: opt: 1078, E(): 8.7e-62, (52.6% identity in 291 aa overlap); and C-terminus highly similar to CAC44687|SCBAC17A6.42c (235 aa), FASTA scores: opt: 911,E(): 3.8e-51, (57.25% identity in 234 aa overlap). Q7TVW7 No conserved hypotheticals Rv3698 NC_002945.3 Mycobrowser_v2 CDS 4066670 4066915 . - 0 Mb3712c rsfb anti-anti-sigma factor rsfb (anti-sigma factor antagonist) (regulator of sigma f b) Mb3712c, -, len: 81 aa. Equivalent to Rv3687c, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Hypothetical protein,showing some similarity to sporulation proteins and sigma-factor genes e.g. Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa) FASTA scores: opt: 163, E(): 0.0007,(31.15% identity in 106 aa overlap); Q9F3A2|SC5F1.27c PUTATIVE ANTI-SIGMA FACTOR ANTAGONIST from Streptomyces coelicolor (114 aa) FASTA scores: opt: 159, E(): 0.0013,(29.8% identity in 104 aa overlap); P73609|SLR1859 HYPOTHETICAL 12.0 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (108 aa) FASTA scores: opt: 152, E(): 0.0034, (32.2% identity in 90 aa overlap); L47358|BACSPOI_1 spoIIA A from Paenibacillus polymyxa (117 aa), FASTA scores: opt: 107, E(): 0.23, (24.8% identity in 113 aa overlap); SQSIGB_4 rsbU, rsbV, rsbW & sigB genes from Steptomyces aureus (108 aa) (28.3% identity in 60 aa overlap); etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. MTCY180_14 and MTCY441 _8. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 5' start due to a single base transversion (g-t) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa). Q7TVX8 No information pathways Rv3687c NC_002945.3 Mycobrowser_v2 CDS 4058545 4058901 . - 0 Mb3706c whiB4 probable transcriptional regulatory protein whib-like whib4 Mb3706c, whiB4, len: 118 aa. Equivalent to Rv3681c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Probable whiB4,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to ML2307 HYPOTHETICAL PROTEIN from Mycobacterium leprae (116 aa). Also highly similar to Q9S2B9|SCH17.13c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 392,E(): 1e-20, (67.95% identity in 78 aa overlap); Q9X951|WBLA HYPOTHETICAL 14.3 KDA PROTEIN from Streptomyces coelicolor (129 aa), FASTA scores: opt: 392,E(): 1.1e-20, (67.95% identity in 78 aa overlap); Q9ACZ0|SCP1.161c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (268 aa), FASTA scores: opt: 273,E(): 4.4e-12, (50.0% identity in 78 aa overlap); Q06387|WHIB-STV from Streptomyces griseocarneus (87 aa) FASTA scores: opt: 231, E(): 1.5e-09, (43.85% identity in 73 aa overlap); etc. Also similar to several putative regulator proteins from Mycobacterium tuberculosis e.g. MTCY7D11_7; MTCY78_13; MTCY10H4_23; MTCY1A6_6; and U00016_29 from M. leprae. N-terminus shortened since first submission. Q7TVY4 No NC_002945.3 Mycobrowser_v2 CDS 4059263 4061695 . + 0 Mb3707 ponA2 PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)] Mb3707, ponA2, len: 810 aa. Equivalent to Rv3682,len: 810 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 810 aa overlap). Probable ponA2,penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities. Almost identical to Q9CB85|PON1|ML2308 PENICILLIN BINDING PROTEIN (CLASS A) from Mycobacterium leprae (803 aa) FASTA scores: opt: 4743, E(): 3.3e-217, (87.7% identity in 806 aa overlap); or P72351|PON1|PBP1 HIGH-MOLECULAR-MASS CLASS A PENICILLIN BINDING PROTEIN from Mycobacterium leprae Cosmid B577 (821 aa), FASTA scores: opt: 4547, E(): 6.3e-208, (88.05% identity in 769 aa overlap) (see first citation below). Also similar to others e.g. Q9XA34|SCH17.14 from Streptomyces coelicolor (428 aa; fragment), FASTA scores: opt: 727, E(): 2.3e-27, (36.55% identity in 413 aa overlap); Q9F9V7|PONA from Mycobacterium smegmatis (715 aa), FASTA scores: opt: 446,E(): 6.6e-14, (27.65% identity in 771 aa overlap) (see second citation below); Q9CCY4|PONA|ML2688 from Mycobacterium leprae (708 aa), FASTA scores: opt: 413,E(): 2.4e-12, (26.8% identity in 660 aa overlap); Q9X6W0|PONB|MRCB|PA4700 from Pseudomonas aeruginosa (774 aa), FASTA scores: opt: 398, E(): 1.3e-11, (27.2% identity in 666 aa overlap); P45345|PBPB_HAEIN|MRCB|PONB|HI1725 (781 aa), FASTA scores: opt: 380, E(): 9.4e-11, (28.6% identity in 601 aa overlap); etc. Also similar to P71707|PONA1|Rv0050|MTCY21.13 PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B (PBP1) from M. tuberculosis (678 aa) FASTA scores: opt: 372, E(): 2e-10,(28.35% identity in 769 aa overlap). SEEMS TO BELONG TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION. Q7TVY3 No NC_002945.3 Mycobrowser_v2 CDS 4061764 4062723 . + 0 Mb3708 conserved protein Mb3708, -, len: 319 aa. Equivalent to Rv3683, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 319 aa overlap). Conserved hypothetical protein, equivalent to Q9CB84|ML2309 HYPOTHETICAL PROTEIN from Mycobacterium leprae (330 aa) FASTA scores: opt: 1791, E(): 9e-107, (85.45% identity in 296 aa overlap). Also similar to Q9X935|SCH66.03 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa) FASTA scores: opt: 610, E(): 1.4e-31, (51.45% identity in 307 aa overlap); and Q9RRY7|YN45_DEIRA|DR2345 HYPOTHETICAL PROTEIN from Deinococcus radiodurans (305 aa) FASTA scores: opt: 243, E(): 3.2e-08, (31.1% identity in 315 aa overlap) and some similarity to other hypothetical bacterial proteins e.g. Q9CF81|YQED from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (278 aa) FASTA scores: opt: 200, E(): 1.6e-05, (26.85% identity in 287 aa overlap). Q7TVY2 No conserved hypotheticals Rv3683 NC_002945.3 Mycobrowser_v2 CDS 4062786 4063826 . + 0 Mb3709 PROBABLE LYASE Mb3709, -, len: 346 aa. Equivalent to Rv3684, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Probable lyase (EC 4.-.-.-), and more specifically a cysteine synthase (EC 4.2.99.8), highly similar to many lyases e.g. Q9K3N2|SCG20A.08c PUTATIVE LYASE from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1469, E(): 3.7e-85, (63.35% identity in 341 aa overlap) (shorter 31 aa at N-terminus); Q9KT44|VC1061 CYSTEINE SYNTHASE (EC 4.2.99.8)/CYSTATHIONINE BETA-SYNTHASE FAMILY PROTEIN from Vibrio cholerae (355 aa), FASTA scores: opt: 1366, E(): 1.1e-78, (63.25% identity in 321 aa overlap); Q9I4R3|PA1061 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (365 aa), FASTA scores: opt: 1311, E(): 3.2e-75, (59.8% identity in 341 aa overlap); Q9PH18|XF0128 CYSTEINE SYNTHASE from Xylella fastidiosa (390 aa), FASTA scores: opt: 1288, E(): 9.5e-74, (58.55% identity in 333 aa overlap) (shorter 34 aa at N-terminus); P55708|Y4XP_RHISN PUTATIVE CYSTEINE SYNTHASE from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (336 aa),FASTA scores: opt: 376, E(): 2.1e-16, (29.2% identity in 315 aa overlap); etc. Equivalent to AAK48153 from Mycobacterium tuberculosis strain CDC1551 (368 aa) but shorter 22 aa. Q7TVY1 No intermediary metabolism and respiration Rv3684 NC_002945.3 Mycobrowser_v2 CDS 4067240 4067704 . - 0 Mb3713c conserved protein Mb3713c, -, len: 154 aa. Equivalent to Rv3688c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Hypothetical protein,similar to other bacterial hypothetical proteins e.g. Q9X934|SCH66.02c from Streptomyces coelicolor (154 aa),FASTA scores: opt: 425, E(): 3.4e-19, (46.1% identity in 154 aa overlap); Q9WZF4|TM0690 from Thermotoga maritima (149 aa), FASTA scores: opt: 326, E(): 3.4e-13, (40.4% identity in 151 aa overlap); Q9PHU3|CJ0573 from Campylobacter jejuni (147 aa), FASTA scores: opt:290 ,E(): 5.1e-11, (36.4% identity in 151 aa overlap); etc. Also some similarity to upstream O69654|Rv3686c|MTV025.034c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. Q7TVX7 No conserved hypotheticals Rv3688c NC_002945.3 Mycobrowser_v2 CDS 4070863 4071939 . + 0 Mb3717 moxR2 probable methanol dehydrogenase transcriptional regulatory protein moxr2 Mb3717, moxR2, len: 358 aa. Equivalent to Rv3692,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Probable moxR2,methanol dehydrogenase regulatory protein, highly similar (generally longer at N-terminus) to Q9KYW3|SCE33.20 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (329 aa), FASTA scores: opt: 1523, E(): 4.2e-74, (70.9% identity in 330 aa overlap); Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa) FASTA scores: opt: 1008, E(): 1.1e-46, (50.8% identity in 313 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 989, E(): 1.1e-45, (50.65% identity in 302 aa overlap); Q9AAN1|CC0566 MOXR PROTEIN from Caulobacter crescentus (323 aa), FASTA scores: opt: 988, E(): 1.3e-45, (52.3% identity in 306 aa overlap); etc. Also similar to O53170|MTV007.26|MOXR|Rv1479 from Mycobacterium tuberculosis (377 aa); and O07392|AF002133_6|MOXR from Mycobacterium avium (309 aa). Also high similarity with several hypothetical bacterial proteins. Q7TVX3 No NC_002945.3 Mycobrowser_v2 CDS 4093259 4094248 . - 0 Mb3738c dnaQ probable dna polymerase iii (epsilon subunit) dnaq Mb3738c, dnaQ, len: 329 aa. Equivalent to Rv3711c,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 329 aa overlap). Probable dnaQ, DNA polymerase III, epsilon subunit (EC 2.7.7.7), similar to many e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328 aa), FASTA scores: opt: 509, E(): 4.2e-25, (41.6% identity in 315 aa overlap); Q9JYS6|NMB1451 from Neisseria meningitidis (serogroup B) (and Q9JTR5|MA1665 from serogroup A) (470 aa), FASTA scores: opt: 247, E(): 2.6e-08, (33.15% identity in 172 aa overlap); O83649|DP3E_TREPA|DNAQ|TP0643 from Treponema pallidum (215 aa), FASTA scores: opt: 240, E(): 3.7e-08, (29.65% identity in 162 aa overlap); P03007|DP3E_ECOLI|MUTD|B0215 from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 208, E(): 4.5e-06, (28.4% identity in 169 aa overlap); etc. Also similar to Q10384|YL91_MYCTU|Rv2191|MTCY190.02 from Mycobacterium tuberculosis (645 aa), FASTA scores: opt: 260, E(): 5e-09,(28.55% identity in 301 aa overlap). Q7TVV5 No NC_002945.3 Mycobrowser_v2 CDS 4072073 4073395 . + 0 Mb3718 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb3718, -, len: 440 aa. Equivalent to Rv3693, len: 440 aa (alternative start at 41910), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 440 aa overlap). Possible conserved membrane protein, similar to Q9KYW2|SCE33.21 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (436 aa), FASTA scores: opt: 875, E(): 3.3e-46,(56.25% identity in 448 aa overlap); Q9AAN0|CC0567 HYPOTHETICAL PROTEIN from Caulobacter crescentus (437 aa),FASTA scores: opt: 355, E(): 2.3e-14, (30.9% identity in 450 aa overlap); P73233|SLR2013 HYPOTHETICAL 48.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (435 aa),FASTA scores: opt: 340, E(): 1.9e-13, (29.7% identity in 438 aa overlap); etc. Equivalent to AAK48162 from Mycobacterium tuberculosis strain CDC1551 (475 aa) but shorter 35 aa. Also similar to other hypothetical proteins from Mycobacterium tuberculosis; MTV014_7; MTV007_27; and MTCY71_36 M. Q7TVX2 No cell wall and cell processes Rv3693 NC_002945.3 Mycobrowser_v2 CDS 4073469 4074461 . - 0 Mb3719c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb3719c, -, len: 330 aa. Equivalent to Rv3694c,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Possible conserved transmembrane protein, highly similar to Q9KZM4|SCE34.01c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (335 aa), FASTA scores: opt: 1113, E(): 2.5e-60, (51.5% identity in 334 aa overlap); and similar to Q9KEW6|BH0733 HYPOTHETICAL PROTEIN from Bacillus halodurans (355 aa), FASTA scores: opt: 381, E(): 6.1e-16,(24.15% identity in 331 aa overlap); Q9AAM9|CC0568 HYPOTHETICAL PROTEIN from Caulobacter crescentus (332 aa),FASTA scores: opt: 352, E(): 3.3e-14, (30.3% identity in 310 aa overlap); P74166|SLR1478 HYPOTHETICAL 35.4 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (317 aa),FASTA scores: opt: 330, E(): 6.8e-13, (25.65% identity in 308 aa overlap); etc. C-terminal end shows similarity to O29631|AF0624|AE001061_10 CONSERVED HYPOTHETICAL PROTEIN (putative nifU protein) from Archaeoglobus fulgidus (185 aa), FASTA scores: opt: 154, E(): 0.021, (29.0% identity in 131 aa overlap). Equivalent to AAK48163 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but shorter 65 aa. Also some similarity to MTCY428_20 HYPOTHETICAL 43.7 KDA PROTEIN from Mycobacterium tuberculosis. Q7TVX1 No cell wall and cell processes Rv3694c NC_002945.3 Mycobrowser_v2 CDS 4074553 4075485 . + 0 Mb3720 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb3720, -, len: 310 aa. Equivalent to Rv3695, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Possible conserved membrane protein, equivalent, but longer 88 aa, to Q9CB83|ML2312 POSSIBLE MEMBRANE PROTEIN from Mycobacterium leprae (196 aa), FASTA scores: opt: 898, E(): 5.2e-36,(71.05% identity in 190 aa overlap). Also highly similar to Q9KZM3|SCE34.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (318 aa), FASTA scores: opt: 740,E(): 2.4e-28, (43.25% identity in 319 aa overlap); and similar to P72718|SLR0254 HYPOTHETICAL 30.4 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (266 aa), FASTA scores: opt: 287, E(): 6.1e-07, (29.6% identity in 260 aa overlap); Q9HW83|PA4318 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 250,E(): 3.5e-05, (32.0% identity in 203 aa overlap); Q9KEW5|BH0734 HYPOTHETICAL PROTEIN from Bacillus halodurans (266 aa), FASTA scores: opt: 168, E(): 0.0047,(25.95% identity in 231 aa overlap); etc. C-terminal end shows some similarity to proline-rich proteins e.g. Q62106 PROLINE-RICH SALIVARY PROTEIN (FRAGMENT) from Mus musculus (Mouse) (188 aa) (36.1% identity in 97 aa overlap). Equivalent to AAK48164 from Mycobacterium tuberculosis strain CDC1551 (269 aa) but longer 41 aa. Q7TVX0 No cell wall and cell processes Rv3695 NC_002945.3 Mycobrowser_v2 CDS 4099275 4099718 . - 0 Mb3745c conserved protein Mb3745c, -, len: 147 aa. Equivalent to Rv3718c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein, equivalent to O69517|ML2332|MLCB2407.18 HYPOTHETICAL 15.5 KDA PROTEIN from Mycobacterium leprae (145 aa), FASTA scores: opt: 780, E(): 1.4e-44, (81.95% identity in 144 aa overlap). Also highly similar to Q9ZBJ2|SC9C7.18 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (147 aa) FASTA scores: opt: 475, E(): 1.7e-24, (52.05% identity in 146 aa overlap); and showing some similarity to various proteins e.g. P27538|PR2_PETCR PATHOGENESIS-RELATED PROTEIN 2 from Petroselinum crispum (Parsley) (Petroselinum hortense) (158 aa); P92918|ALL2_APIGR MAJOR ALLERGEN API G 2 from Apium graveolens (Celery) (159 aa); etc. Q7TVV0 No conserved hypotheticals Rv3718c NC_002945.3 Mycobrowser_v2 CDS 4159994 4161190 . - 0 Mb3807c POSSIBLE AMINOTRANSFERASE Mb3807c, -, len: 398 aa. Equivalent to Rv3778c,len: 398 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 398 aa overlap). Possible aminotransferase (EC 2.6.1.-), equivalent to Q9CD97|ML0117 HYPOTHETICAL PROTEIN from Mycobacterium leprae (398 aa) FASTA scores: opt: 2141, E(): 1.2e-123, (83.4% identity in 398 aa overlap). Also similar to others e.g. Q9K3K6|SCG20A.34 PUTATIVE AMINOTRANSFERASE from Streptomyces coelicolor (400 aa), FASTA scores: opt: 723,E(): 6.5e-37, (36.3% identity in 402 aa overlap); Q9KSS2|VC1184 NIFS-RELATED PROTEIN (AMINOTRANSFERASE-RELATED) from Vibrio cholerae (416 aa) FASTA scores: opt: 595, E(): 4.5e-29, (31.35% identity in 405 aa overlap); Q98NK4|MLR0102 AMINOTRANSFERASE from Rhizobium loti (Mesorhizobium loti) (425 aa), FASTA scores: opt: 563, E(): 4.2e-27, (29.4% identity in 408 aa overlap); Q9RY03|DR0151 NIFS-RELATED PROTEIN from Deinococcus radiodurans (401 aa), FASTA scores: opt: 484,E(): 2.7e-22, (32.35% identity in 399 aa overlap); Q9A766|CC1860 AMINOTRANSFERASE CLASS V from Caulobacter crescentus (408 aa), FASTA scores: opt: 390, E(): 1.5e-16,(27.85% identity in 413 aa overlap); etc. Q7TVP3 No intermediary metabolism and respiration Rv3778c NC_002945.3 Mycobrowser_v2 CDS 4076348 4077103 . - 0 Mb3722c glpKa PROBABLE GLYCEROL KINASE GLPKA [FIRST PART] (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK) Mb3722c, glpKa, len: 251 aa. Equivalent to 5' end of Rv3696c, len: 517 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 191 aa overlap). Probable glpK, glycerol kinase (EC 2.7.1.30), equivalent to Q9CB81|GLPK_MYCLE|ML2314 GLYCEROL KINASE from Mycobacterium leprae (508 aa), FASTA scores: opt: 3120,E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606,E(): 1.1e-156, (75.35% identity in 503 aa overlap); Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503 aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa), FASTA scores: opt: 1838, E(): 2.7e-108,(54.8% identity in 498 aa overlap); P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3% identity in 499 aa overlap); etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1, PS00070 Aldehyde dehydrogenases cysteine active site, PS00445 FGGY family of carbohydrate kinases signature 2. BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, glpK exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g), splits glpK into 2 parts, glpKa and glpKb and removes activity. Q7TVW9 No NC_002945.3 Mycobrowser_v2 CDS 4077153 4077590 . - 0 Mb3723c vapc48 possible toxin vapc48. contains pin domain. Mb3723c, -, len: 145 aa. Equivalent to Rv3697c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 145 aa overlap). Possible conserved membrane protein, similar to many proteins from Mycobacterium tuberculosis e.g. Q10800|YS72_MYCTU|Rv2872|MT2939|MTCY274.03 (147 aa) FASTA scores: opt: 223, E(): 7.3e-08, (32.6% identity in 141 aa overlap); O53501|Rv2103c|MTV020.03 (144 aa), FASTA scores: opt: 215, E(): 2.4e-07, (31.4% identity in 137 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 192, E(): 7.6e-06, (31.25% identity in 144 aa overlap); etc. Q7TVW8 No virulence, detoxification, adaptation Rv3697c NC_002945.3 Mycobrowser_v2 CDS 4131734 4132096 . + 0 Mb3770 nmtr metal sensor transcriptional regulator (arsr-smtb family) Mb3770, -, len: 120 aa. Equivalent to Rv3744, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). Probable transcriptional regulator, possible arsR family, highly similar to many e.g. Q9ZBF4|SC9B5.26c from Streptomyces coelicolor (120 aa), FASTA scores: opt: 480, E(): 2.4e-24,(63.25% identity in 117 aa overlap); O31844|YOZA YOZA REGULATOR from Bacillus subtilis (107 aa), FASTA scores: opt: 249, E(): 1.6e-09, (44.8% identity in 96 aa overlap); P30340|SMTB_SYNP7|SMTB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (122 aa), FASTA scores: opt: 230, E(): 2.9e-08, (46.0% identity in 87 aa overlap); etc. Equivalent to AAK48216 from Mycobacterium tuberculosis strain CDC1551 (135 aa) but shorter 15 aa. Also similar to MTCY27_22; MTCY39_25; and MTCY441_12. Contains helix-turn-helix motif at aa 47-68 (Score 1815, +5.37 SD). SEEMS TO BELONG TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TVS9 No regulatory proteins Rv3744 NC_002945.3 Mycobrowser_v2 CDS 4079392 4080093 . + 0 Mb3725 conserved protein Mb3725, -, len: 233 aa. Equivalent to Rv3699, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins e.g. Q9P3V6|SPAC1348.04 (alias Q9P3E7|SPAC750.03c or Q9P7U5|SPAC977.03) from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 188, E(): 7.5e-05, (31.65% identity in 120 aa overlap); and Q9KB70|BH2058 from Bacillus halodurans (241 aa) FASTA scores: opt: 185, E(): 0.00018, (27.8% identity in 162 aa overlap); Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 166, E(): 0.0025, (29.95% identity in 147 aa overlap); etc. Also highly similar to O06426|Rv0560c|MTCY25D10.39c HYPOTHETICAL 25.9 KDA PROTEIN from Mycobacterium tuberculosis (241 aa), FASTA scores: opt: 690, E(): 6.5e-36, (53.4% identity in 234 aa overlap); and similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c (212 aa) FASTA scores: opt: 378, E(): 1.5e-16, (35.4% identity in 192 aa overlap); P71972|Rv2675c|MTCY441.44c (250 aa) FASTA scores: opt: 297, E(): 2e-11, (31.1% identity in 193 aa overlap); etc. Q7TVW6 No conserved hypotheticals Rv3699 NC_002945.3 Mycobrowser_v2 CDS 4161280 4163280 . + 0 Mb3808 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ALANINE AND LEUCINE RICH Mb3808, -, len: 666 aa. Equivalent to Rv3779, len: 666 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 666 aa overlap). Probable conserved transmembrane ala-, leu-rich protein, equivalent to Q9CD98|ML0116 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (654 aa), FASTA scores: opt: 1991, E(): 2e-112,(66.5% identity in 666 aa overlap). Shows some similarity with Q9RRU0|DR2395 PUTATIVE NA+/H+ ANTIPORTER from Deinococcus radiodurans (458 aa), FASTA scores: opt: 138,E(): 0.69, (31.9% identity in 138 aa overlap). Q7TVP2 No cell wall and cell processes Rv3779 NC_002945.3 Mycobrowser_v2 CDS 4080096 4081268 . - 0 Mb3726c CONSERVED HYPOTHETICAL PROTEIN Mb3726c, -, len: 390 aa. Equivalent to Rv3700c,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Conserved hypothetical protein; could be a transferase (EC 2.-.-.-) or a lyase (EC 4.-.-.-). Indeed, similar to various enzymes e.g. Q53824|CAC CAPREOMYCIN ACETYLTRANSFERASE from Streptomyces capreolus (359 aa), FASTA scores: opt: 338,E(): 1.1e-12, (33.35% identity in 363 aa overlap); Q9HXX3|CSD_PSEAE|PA3667 PROBABLE CYSTEINE DESULFURASE (EC 4.4.1.-) from Pseudomonas aeruginosa (401 aa) FASTA scores: opt: 260, E(): 4.8e-08, (30.2% identity in 404 aa overlap); Q9X815|SC6G10.30 PUTATIVE AMINOTRANSFERASE from Streptomyces coelicolor (460 aa), FASTA scores: opt: 243,E(): 5.4e-07, (29.15% identity in 374 aa overlap); Q9A761|CC1865 AMINOTRANSFERASE CLASS V from Caulobacter crescentus (379 aa), FASTA scores: opt: 234, E(): 1.6e-06,(27.95% identity in 383 aa overlap); O74351|NFS1_SCHPO|SPBC21D10.11c PROBABLE CYSTEINE DESULFURASE from Schizosaccharomyces pombe (Fission yeast) (498 aa), FASTA scores: opt: 232, E(): 2.5e-06, (29.1% identity in 285 aa overlap); Q9RME8|NIFS NIFS PROTEIN (CYSTEINE DESULFURASE, TRNA SPLICING PROTEIN) from Zymomonas mobilis (370 aa), FASTA scores: opt: 230, E(): 2.6e-06, (32.85% identity in 201 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7TVW5 No intermediary metabolism and respiration Rv3700c NC_002945.3 Mycobrowser_v2 CDS 4081299 4082264 . - 0 Mb3727c CONSERVED HYPOTHETICAL PROTEIN Mb3727c, -, len: 321 aa. Equivalent to Rv3701c,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 321 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9RCZ8|SCM1.46 from Streptomyces coelicolor (251 aa), FASTA scores: opt: 897, E(): 1.1e-50, (59.9% identity in 242 aa overlap); P73759|SLR0865 from Synechocystis sp. strain PCC 6803 (337 aa), FASTA scores: opt: 779, E(): 5.7e-43, (40.35% identity in 327 aa overlap); Q9GWA1|LM12.997 from Leishmania major (383 aa) FASTA scores: opt: 616, E(): 2.1e-32, (39.05% identity in 297 aa overlap); etc. Q7TVW4 No conserved hypotheticals Rv3701c NC_002945.3 Mycobrowser_v2 CDS 4082261 4082962 . - 0 Mb3728c CONSERVED HYPOTHETICAL PROTEIN Mb3728c, -, len: 233 aa. Equivalent to Rv3702c,len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins Q9RCZ9|SCM1.45 from Streptomyces coelicolor (271 aa), FASTA scores: opt: 383, E(): 2.3e-17, (44.85% identity in 252 aa overlap); and P54004|Y199_SYNY3|SLR0199 from Synechocystis sp. strain PCC 6803 (304 aa), FASTA scores: opt: 292, E(): 1.7e-11, (30.05% identity in 263 aa overlap); and similar to others e.g. Q9KMU4|VCA0225 from Vibrio cholerae (254 aa), FASTA scores: opt: 260, E(): 1.6e-09, (29.8% identity in 245 aa overlap). Equivalent to AAK48172 from Mycobacterium tuberculosis strain CDC1551 (194 aa) but longer 39 aa. Q7TVW3 No conserved hypotheticals Rv3702c NC_002945.3 Mycobrowser_v2 CDS 4082962 4084239 . - 0 Mb3729c CONSERVED HYPOTHETICAL PROTEIN Mb3729c, -, len: 425 aa. Equivalent to Rv3703c,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 425 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. Q9RD00|SCM1.44 from Streptomyces coelicolor (446 aa), FASTA scores: opt: 1480, E(): 1.4e-85, (53.9% identity in 421 aa overlap); P72841|SLR1303 from Synechocystis sp. strain PCC 6803 (410 aa), FASTA scores: opt: 533, E(): 4.5e-26, (36.6% identity in 429 aa overlap); Q9KYH7|SCC61A.16 from Streptomyces coelicolor (256 aa), FASTA scores: opt: 266, E(): 1.9e-09, (32.25% identity in 248 aa overlap); etc. Also similar to P95060|Rv0712|MTCY210.31 HYPOTHETICAL 32.7 KDA PROTEIN from Mycobacterium tuberculosis (299 aa), FASTA scores: opt: 243, E(): 5.9e-08, (30.6% identity in 304 aa overlap). Q7TVW2 No conserved hypotheticals Rv3703c NC_002945.3 Mycobrowser_v2 CDS 4084236 4085534 . - 0 Mb3730c gshA GLUTAMATE--CYSTEINE LIGASE GSHA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE) Mb3730c, gshA, len: 432 aa. Equivalent to Rv3704c,len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Possible gshA,glutamate--cysteine ligase (EC 6.3.2.2), similar to many e.g. Q9A2Z2|CC3414 GLUTAMATE--CYSTEINE LIGASE from Caulobacter crescentus (453 aa), FASTA scores: opt: 404,E(): 5.9e-17, (30.45% identity in 312 aa overlap); Q9SEH0|GSH1 GAMMA-GLUTAMYLCYSTEINYL SYNTHETASE PRECURSOR from Pisum sativum (Garden pea) (499 aa), FASTA scores: opt: 400, E(): 1.1e-16, (26.4% identity in 439 aa overlap); Q9RH09|GSH GAMMA-GLUTAMYLCYSTEINE SYNTHETASE from Zymomonas mobilis (462 aa), FASTA scores: opt: 397,E(): 1.6e-16, (28.95% identity in 304 aa overlap); P46309|GSH1_ARATH|GSH1|AT4G23100|F7H19.290 GLUTAMATE--CYSTEINE LIGASE from Arabidopsis thaliana (Mouse-ear cress) (522 aa), FASTA scores: opt: 395, E(): 2.3e-16, (27.25% identity in 385 aa overlap); etc. But note that this putative protein is also similar to Q9JMV4|GSHA PUTATIVE GLUTATHIONE SYNTHETASE (FRAGMENT) from Bradyrhizobium japonicum (460 aa), FASTA scores: opt: 498, E(): 1.3e-22, (33.35% identity in 333 aa overlap) (no significant publications found (August 2001). Q7TVW1 No NC_002945.3 Mycobrowser_v2 CDS 4085666 4086310 . - 0 Mb3731c conserved protein Mb3731c, -, len: 214 aa. Equivalent to Rv3705c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical protein, equivalent to Q9CB80|ML2320 HYPOTHETICAL PROTEIN from Mycobacterium leprae (215 aa) FASTA scores: opt: 1145, E(): 5.9e-68, (79.45% identity in 214 aa overlap). Some similarity to the C-terminal end of Q11053|PKNH_MYCTU|Rv1266c|MT1304|MTCY50.16 PROBABLE SERINE/THREONINE-PROTEIN from Mycobacterium tuberculosis (626 aa), FASTA scores: opt: 175, E(): 0.0005, (24.9% identity in 201 aa overlap); and to the N-terminal end of P23903|E13B_BACCI|GLCA GLUCAN ENDO-1,3-BETA-GLUCOSIDASE A1 PRECURSOR from Bacillus circulans (682 aa), FASTA scores: opt: 122, E(): 1.6, (25.6% identity in 164 aa overlap). Q7TVW0 No conserved hypotheticals Rv3705c NC_002945.3 Mycobrowser_v2 CDS 4086439 4086828 . - 0 Mb3732c CONSERVED HYPOTHETICAL PROLINE RICH PROTEIN Mb3732c, -, len: 129 aa. Equivalent to Rv3705A,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to downstream ORF O69674|Rv3706c|MTV025.054c CONSERVED HYPOTHETICAL PROLINE RICH PROTEIN from Mycobacterium tuberculosis (106 aa),FASTA scores: opt: 245, E(): 0.00013, (40.7% identity in 113 aa overlap). Q7TVV9 No conserved hypotheticals Rv3705A NC_002945.3 Mycobrowser_v2 CDS 4087378 4088388 . - 0 Mb3734c CONSERVED HYPOTHETICAL PROTEIN Mb3734c, -, len: 336 aa. Equivalent to Rv3707c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Equivalent to Q9CB79|ML2321 HYPOTHETICAL PROTEIN from Mycobacterium leprae (336 aa), FASTA scores: opt: 1948, E(): 6.7e-110,(81.95% identity in 332 aa overlap); and P41402|YASD_MYCSM HYPOTHETICAL 35.9 KDA PROTEIN IN THE ASPARTOKINASE GENE CLUSTER from Mycobacterium smegmatis (333 aa), FASTA scores: opt: 1731, E(): 7.4e-97, (70.85% identity in 333 aa overlap). Q7TVV7 No conserved hypotheticals Rv3707c NC_002945.3 Mycobrowser_v2 CDS 4101196 4102458 . + 0 Mb3747 POSSIBLE FATTY ACID SYNTHASE Mb3747, -, len: 420 aa. Equivalent to Rv3720, len: 420 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 420 aa overlap). Possible fatty-acyl-phospholipid synthase (EC 2.1.1.-), equivalent to Q9CB74|ML2334 (alias O69515|MLCB2407.16c, 439 aa) HYPOTHETICAL PROTEIN from Mycobacterium leprae (420 aa) FASTA scores: opt: 2508, E(): 4.7e-153, (86.45% identity in 420 aa overlap). Also similar (especially at the C-terminus) to various fatty-acid synthases (principally cyclopropane-fatty-acyl-phospholipid synthases (EC 2.1.1.79)) and hypothetical proteins e.g. Q9KZ58|SCE25.32c PUTATIVE FATTY ACID SYNTHASE from Streptomyces coelicolor (438 aa), FASTA scores: opt: 1101, E(): 5.5e-63, (46.1% identity in 425 aa overlap); P31049|YLP3_PSEPU HYPOTHETICAL 44.7 KDA PROTEIN from Pseudomonas putida (394 aa), FASTA scores: opt: 810, E(): 2.1e-44, (46.4% identity in 293 aa overlap); Q9HT28|PA5546 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (394 aa), FASTA scores: opt: 804, E(): 5.2e-44, (40.7% identity in 371 aa overlap); Q9RSD7|DR2187 PUTATIVE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Deinococcus radiodurans (462 aa), FASTA scores: opt: 747,E(): 2.6e-40, (35.95% identity in 409 aa overlap); BAB50831|Q98ET6|MLL4091 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Rhizobium loti (Mesorhizobium loti) (422 aa), FASTA scores: opt: 674, E(): 1.1e-35, (39.1% identity in 284 aa overlap); P30010|CFA_ECOLI|CDFA|B1661 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIP SYNTHASE from Escherichia coli strain K12 (381 aa), FASTA scores: opt: 530, E(): 1.7e-26, (33.65% identity in 312 aa overlap); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa); P96911|Rv0621|MTCY20H10 (354 aa); O50416|LPQD|Rv3390|MTV004.48 (236 aa); etc. Q7TVU8 No lipid metabolism Rv3720 NC_002945.3 Mycobrowser_v2 CDS 4182809 4186105 . + 0 Mb3824 embB INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBB (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE) Mb3824, embB, len: 1098 aa. Equivalent to Rv3795,len: 1098 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1098 aa overlap). embB, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below),equivalent to P71486|EMBB ARABINOSYL TRANSFERASE from Mycobacterium avium (1065 aa), FASTA scores: opt: 4998,E(): 0, (83.25% identity in 1076 aa overlap); Q9CDA9|EMBB|ML0104 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1083 aa), FASTA scores: opt: 4706,E(): 0, (78.0% identity in 1101 aa overlap); O30406|EMBB (alias Q50395) PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1082 aa), FASTA scores: opt: 4163, E(): 0, (68.4% identity in 1091 aa overlap); etc. Also similar to Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 2482, E(): 5e-135, (44.7% identity in 1101 aa overlap); Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa), FASTA scores: opt: 2259, E(): 3.4e-122, (43.4% identity in 1104 aa overlap); etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 2276, E(): 3.6e-123, (44.45% identity in 1118 aa overlap); and P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1288, E(): 2.5e-66, (42.35% identity in 1114 aa overlap). Supposed regulated by embR|Rv1267c. X2BQ26,Q7TVN3 No NC_002945.3 Mycobrowser_v2 CDS 4088528 4089565 . - 0 Mb3735c asd ASPARTATE-SEMIALDEHYDE DEHYDROGENASE ASD (ASA DEHYDROGENASE) (ASADH) (ASPARTIC SEMIALDEHYDE DEHYDROGENASE) (L-ASPARTATE-BETA-SEMIALDEHYDE DEHYDROGENASE) Mb3735c, asd, len: 345 aa. Equivalent to Rv3708c,len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 345 aa overlap). asd,aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) (see citation below), equivalent to many e.g. P47730|DHAS_MYCBO|ASD from Mycobacterium bovis (345 aa) FASTA scores: opt: 2150, E(): 1.6e-124, (97.7% identity in 345 aa overlap); or Q9JN40|ASD from Mycobacterium bovis (323 aa), FASTA scores: opt: 2021, E(): 1.2e-116, (97.5% identity in 323 aa overlap); Q9CB78|ASD|ML2322 from Mycobacterium leprae (351 aa), FASTA scores: opt: 1889,E(): 1.6e-108, (84.45% identity in 347 aa overlap); P41404|DHAS_MYCSM|ASD from Mycobacterium smegmatis (346 aa), FASTA scores: opt: 1801, E(): 3.9e-103, (80.3% identity in 345 aa overlap); etc. Contains PS01103 Aspartate-semialdehyde dehydrogenase signature. BELONGS TO THE ASPARTATE-SEMIALDEHYDE DEHYDROGENASE FAMILY. X2BNY3,P0A543 No NC_002945.3 Mycobrowser_v2 CDS 4089566 4090831 . - 0 Mb3736c ask ASPARTOKINASE ASK (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA SUBUNIT (ASK-ALPHA); AND ASPARTOKINASE BETA SUBUNIT (ASK-BETA)] Mb3736c, ask, len: 421 aa. Equivalent to Rv3709c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 421 aa overlap). ask, aspartokinase (EC 2.7.2.4) (see citation below), equivalent to Q9CB77|ASK|ML2323 from Mycobacterium leprae (421 aa),FASTA scores: opt: 2531, E(): 2e-140, (92.65% identity in 421 aa overlap); and P41403|AK_MYCSM|ASK from Mycobacterium smegmatis (421 aa), FASTA scores: opt: 2423,E(): 4e-134, (88.1% identity in 421 aa overlap); and to several other organisms e.g. Q9RQ25|ASKA from Amycolatopsis mediterranei (421 aa), FASTA scores: opt: 2026, E(): 5.8e-111, (72.2% identity in 421 aa overlap). Contains PS00324 Aspartokinase signature. BELONGS TO THE ASPARTOKINASE FAMILY. ALTERNATIVE PRODUCTS: THE ALPHA AND BETA SUBUNITS OF ASPARTOKINASE ARE PRODUCED BY THE USE OF ALTERNATIVE INITIATION SITES (BY SIMILARITY). X2BPD7,P0A4Z9 No NC_002945.3 Mycobrowser_v2 CDS 4091088 4093193 . + 0 Mb3737 leuA 2-isopropylmalate synthase leua (alpha-isopropylmalate synthase) (alpha-ipm synthetase) (ipms) Mb3737, leuA, len: 701 aa. Similar to Rv3710, len: 644 aa, from Mycobacterium tuberculosis strain H37Rv,(91.7% identity in 701 aa overlap). leuA,alpha-isopropylmalate synthase (EC 4.1.3.12) (see citations below), equivalent to Q9CB76|LEUA|ML2324 2-ISOPROPYLMALATE SYNTHASE from Mycobacterium leprae (607 aa), FASTA scores: opt: 3291, E(): 3.7e-192, (80.7% identity in 642 aa overlap). Also highly similar to many e.g. P42455|LEU1_CORGL|LEUA from Corynebacterium glutamicum (Brevibacterium flavum) (616 aa), FASTA scores: opt: 2547, E(): 5.3e-147, (63.25% identity in 645 aa overlap); O31046|LEU1_STRCO|LEUA from Streptomyces coelicolor (573 aa), FASTA scores: opt: 2226, E(): 1.5e-127, (57.8% identity in 616 aa overlap); BAB49833|Q98HN3|MLR2792 from Rhizobium loti (Mesorhizobium loti) (588 aa), FASTA scores: opt: 1849, E(): 1.1e-104,(58.0% identity in 536 aa overlap); etc. Equivalent to AAK48181 from Mycobacterium tuberculosis strain CDC1551 (659 aa) but shorter 15 aa. Contains PS00815 and PS00816 Alpha-isopropylmalate and homocitrate synthases signatures 1 and 2. BELONGS TO THE ALPHA-IPM SYNTHETASE / HOMOCITRATE SYNTHASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame insertion of 171 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis (701 aa versus 644 aa). X2BP46,Q7TVV6 No NC_002945.3 Mycobrowser_v2 CDS 4267771 4272354 . - 0 Mb3889c gltB probable ferredoxin-dependent glutamate synthase [nadph] (large subunit) gltb (l-glutamate synthase) (l-glutamate synthetase) (nadh-glutamate synthase) (glutamate synthase (nadh))(nadph-gogat) Mb3889c, gltB, len: 1527 aa. Equivalent to Rv3859c,len: 1527 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1527 aa overlap). Probable gltB,ferredoxin-dependent glutamate synthase large subunit (EC 1.4.1.13), equivalent to Q9CDD5|GLTB|ML0061 PUTATIVE FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt: 5790, E(): 0, (63.25% identity in 1534 aa overlap); P39812|GLTB_BACSU|GLTA from Bacillus subtilis (1520 aa), FASTA scores: opt: 3445, E(): 2.8e-196, (52.25% identity in 1531 aa overlap); etc. SIMILAR TO OTHER GLUTAMATE SYNTHASES. Q7TVH7 No NC_002945.3 Mycobrowser_v2 CDS 4094441 4095682 . + 0 Mb3739 POSSIBLE LIGASE Mb3739, -, len: 413 aa. Equivalent to Rv3712, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 413 aa overlap). Possible ligase (EC 6.-.-.-), equivalent to O69522|ML2326|MLCB2407.24c HYPOTHETICAL 43.8 KDA PROTEIN (POSSIBLE LIGASE) from Mycobacterium leprae (411 aa), FASTA scores: opt: 2265,E(): 8e-129, (84.25% identity in 413 aa overlap). Also similar to ligases or hypothetical proteins e.g. Q9FCA1|2SCG58.12 PUTATIVE LIGASE from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1168, E(): 6.7e-63, (45.8% identity in 406 aa overlap); P74303|SLR0938 HYPOTHETICAL 50.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (459 aa), FASTA scores: opt: 392, E(): 3.1e-16, (28.45% identity in 397 aa overlap); Q99ZX1|SPY1035 PUTATIVE UDP-N-ACETYLMURAMYL TRIPEPTIDE SYNTHETASE (EC 6.3.2.13) from Streptococcus pyogenes (445 aa), FASTA scores: opt: 335, E(): 8.1e-13,(29.2% identity in 438 aa overlap); Q9CGJ0|YLBD HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (449 aa), FASTA scores: opt: 324, E(): 3.8e-12, (28.75% identity in 445 aa overlap); Q9ZGG7|MURC UDP-N-ACETYLMURAMYL TRIPEPTIDE SYNTHETASE from Heliobacillus mobilis (455 aa), FASTA scores: opt: 292, E(): 3.2e-10, (30.75% identity in 449 aa overlap); etc. Q7TVV4 No intermediary metabolism and respiration Rv3712 NC_002945.3 Mycobrowser_v2 CDS 4132180 4132392 . - 0 Mb3771c CONSERVED HYPOTHETICAL PROTEIN Mb3771c, -, len: 70 aa. Equivalent to Rv3745c, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 70 aa overlap). Conserved hypothetical protein, highly similar to others e.g. N-terminus of Q9X4E6 HYPOTHETICAL 13.4 KDA PROTEIN from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (124 aa), FASTA scores: opt: 279, E(): 4.4e-14, (59.4% identity in 69 aa overlap); N-terminus of Q9A2A6|CC3660 HYPOTHETICAL PROTEIN from Caulobacter crescentus (172 aa) FASTA scores: opt: 272, E(): 1.9e-13, (63.35% identity in 60 aa overlap); N-terminus of P74345|SLR1628 HYPOTHETICAL 14.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (134 aa), FASTA scores: opt: 233, E(): 1.3e-10, (54.85% identity in 62 aa overlap); etc. Q7TVS8 No conserved hypotheticals Rv3745c NC_002945.3 Mycobrowser_v2 CDS 4095687 4096382 . + 0 Mb3740 cobQ2 POSSIBLE COBYRIC ACID SYNTHASE COBQ2 Mb3740, cobQ2, len: 231 aa. Equivalent to Rv3713,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible cobQ2,cobyric acid synthase (EC undetermined), equivalent to O69521|ML2327|MLCB2407.23c HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium leprae (230 aa), FASTA scores: opt: 1313, E(): 4.7e-73, (86.1% identity in 230 aa overlap). Also partially similar to several cobyric acid synthases and hypothetical proteins e.g. Q9FCA0|2SCG58.13 HYPOTHETICAL 26.2 KDA PROTEIN from Streptomyces coelicolor (242 aa), FASTA scores: opt: 639, E(): 6.2e-32, (46.6% identity in 234 aa overlap); Q9ZGG8|COBQ COBYRIC ACID SYNTHASE from Heliobacillus mobilis (252 aa), FASTA scores: opt: 501, E(): 1.7e-23, (40.75% identity in 206 aa overlap); BAB58053|SAV1891 HYPOTHETICAL 27.4 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (243 aa),FASTA scores: opt: 400, E(): 2.3e-17, (35.95% identity in 217 aa overlap); Q9CGJ1|COBQ COBYRIC ACID SYNTHASE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (261 aa), FASTA scores: opt: 353, E(): 1.8e-14, (35.3% identity in 201 aa overlap); O26880|COBQ_METTH|MTH787 PROBABLE COBYRIC ACID SYNTHASE from Methanobacterium thermoautotrophicum (504 aa), FASTA scores: opt: 201, E(): 5.6e-05, (33.35% identity in 171 aa overlap); etc. Also similar to hypothetical mycobacterial proteins O05811|COBB_MYCTU|Rv2848c|MT2914|MTCY24A1.09 (457 aa) and P71842|Rv0789c|MTCY369.33c (199 aa). SEEMS TO BELONG TO THE COBB/COBQ FAMILY, COBQ SUBFAMILY. Q7TVV3 No NC_002945.3 Mycobrowser_v2 CDS 4172074 4173459 . + 0 Mb3819 dpre1 decaprenylphosphoryl-beta-d-ribose 2'-oxidase Mb3819, -, len: 461 aa. Equivalent to Rv3790, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable oxidoreductase (EC 1.-.-.-), equivalent to Q9CDA4|ML0109 PUTATIVE FAD-LINKED OXIDOREDUCTASE from Mycobacterium leprae (460 aa), FASTA scores: opt: 2722, E(): 1.4e-161,(86.55% identity in 461 aa overlap). Also highly similar to others e.g. Q9KZA4|SC5G8.10c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (457 aa), FASTA scores: opt: 1336, E(): 1.7e-75, (47.1% identity in 452 aa overlap); Q98KY4|MLL1265 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (449 aa), FASTA scores: opt: 636,E(): 4.9e-32, (36.0% identity in 439 aa overlap); Q9HDX8|SPAPB1A10.12c PUTATIVE D-ARABINONO-1,4-LACTONE OXIDASE from Schizosaccharomyces pombe (Fission yeast) (461 aa), FASTA scores: opt: 297, E(): 5.6e-11, (23.55% identity in 467 aa overlap); etc. C-terminal end has a high similarity to Q9AQD0 PUTATIVE OXIDOREDUCTASE (FRAGMENT) from Mycobacterium smegmatis (149 aa) FASTA scores: opt: 901, E(): 6.5e-49, (86.6% identity in 149 aa overlap). Q7TVN6 No lipid metabolism Rv3790 NC_002945.3 Mycobrowser_v2 CDS 4096391 4097281 . - 0 Mb3741c CONSERVED HYPOTHETICAL PROTEIN Mb3741c, -, len: 296 aa. Equivalent to Rv3714c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Conserved hypothetical protein, highly similar to O07396|MAV346 MAV346 PROTEIN from Mycobacterium avium (346 aa) FASTA scores: opt: 834, E(): 2.2e-46, (50.0% identity in 286 aa overlap); and also highly similar to several proteins from Mycobacterium tuberculosis e.g. O53421|Rv1073|MTV017.26 (283 aa), FASTA scores: opt: 869, E(): 1e-48, (51.1% identity in 270 aa overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FASTA scores: opt: 775, E(): 1.3e-42, (46.35% identity in 289 aa overlap); P96837|Rv3555c|MTCY06G11.02c (289 aa), FASTA scores: opt: 733, E(): 5.9e-40, (44.15% identity in 281 aa overlap); etc. Partially similar to Q9Z512|UVRC_STRCO|SCC54.13c EXCINUCLEASE ABC SUBUNIT C from Streptomyces coelicolor (728 aa), FASTA scores: opt: 122, E(): 2.5, (27.0% identity in 174 aa overlap). Equivalent to AAK48186 from Mycobacterium tuberculosis strain CDC1551 (341 aa) but shorter 45 aa. Q7TVV2 No conserved hypotheticals Rv3714c NC_002945.3 Mycobrowser_v2 CDS 4097349 4097960 . - 0 Mb3742c recR probable recombination protein recr Mb3742c, recR, len: 203 aa. Equivalent to Rv3715c,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Probable recR,recombination protein, equivalent to O69520|RECR_MYCLE|ML2329|MLCB2407.21 RECOMBINATION PROTEIN from Mycobacterium leprae (203 aa), FASTA scores: opt: 1246, E(): 9.2e-71, (91.6% identity in 202 aa overlap). Also highly similar to many e.g. Q9XAI4|RECR_STRCO|SC66T3.29c from Streptomyces coelicolor (199 aa), FASTA scores: opt: 952, E(): 1.9e-52, (68.3% identity in 202 aa overlap); P24277|RECR_BACSU|RECM|RECD from Bacillus subtilis (198 aa), FASTA scores: opt: 696,E(): 1.8e-36, (50.5% identity in 198 aa overlap); Q9ZNA2|RECR_DEIRA|DR0198 from Deinococcus radiodurans (220 aa), FASTA scores: opt: 673, E(): 5.2e-35, (49.75% identity in 195 aa overlap); etc. BELONGS TO THE RECR FAMILY. X2BP52,P65991 No NC_002945.3 Mycobrowser_v2 CDS 4097972 4098373 . - 0 Mb3743c conserved protein Mb3743c, -, len: 133 aa. Equivalent to Rv3716c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, equivalent to O69519|Y1B6_MYCLE|ML2330|MLCB2407.20 HYPOTHETICAL 11.9 KDA PROTEIN from Mycobacterium leprae (116 aa), FASTA scores: opt: 616, E(): 2.6e-21, (84.55% identity in 110 aa overlap). Also highly similar to hypothetical ~12 kDa proteins in the vicinity of recR from other bacteria e.g. Q9XAI3|YT3D_STRCO|SC66T3.30c HYPOTHETICAL 11.7 KDA PROTEIN from Streptomyces coelicolor (115 aa), FASTA scores: opt: 379, E(): 9.5e-11, (50.8% identity in 122 aa overlap); BAB56641|SAV0479 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (105 aa) FASTA scores: opt: 295, E(): 4.9e-07, (41.75% identity in 103 aa overlap); Q99WC4P24281|YAAK_BACSU HYPOTHETICAL 11.8 KDA PROTEIN IN DNAZ-RECR INTERGENIC REGION from Bacillus subtilis (107 aa), FASTA scores: opt: 272, E(): 5.3e-06,(39.4% identity in 104 aa overlap); P17577|YBAB_ECOLI|B0471|Z0588|ECS0524 from Escherichia coli strain K and O157:H7 (109 aa), FASTA scores: opt: 256, E(): 2.8e-05, (38.0% identity in 100 aa overlap); etc. Contains probable coiled-coil domain from aa 1-40. SEEMS TO BELONG TO THE UPF0133 FAMILY. X2BPN2,P0A655 No conserved hypotheticals Rv3716c NC_002945.3 Mycobrowser_v2 CDS 4098508 4099233 . + 0 Mb3744 CONSERVED HYPOTHETICAL PROTEIN Mb3744, -, len: 241 aa. Equivalent to Rv3717, len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Conserved hypothetical protein, equivalent to O69518|MLCB2407.19c (alias Q9CB75|ML2331 256 aa) HYPOTHETICAL 25.1 KDA PROTEIN from Mycobacterium leprae (244 aa), FASTA scores: opt: 1325, E(): 5.7e-74, (81.95% identity in 244 aa overlap). Also similar to Q9KXK7|SCC53.04 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 536, E(): 1.2e-25, (41.2% identity in 233 aa overlap); and shows similarity with C-terminal end of other proteins e.g. Q9RMZ0|PXO2-42 PXO2-42 PROTEIN from Bacillus anthracis (531 aa), FASTA scores: opt: 191, E(): 0.00022,(26.6% identity in 222 aa overlap); Q9RTX0 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE (603 aa); Q9LCR4|CWLU CWLU PROTEIN from Paenibacillus polymyxa (Bacillus polymyxa) (524 aa), FASTA scores: opt: 141, E(): 0.24,(29.2% identity in 219 aa overlap); etc. Shows similarity with C-terminal end of O53593|CWLM|Rv3915|MTV028.06 PUTATIVE HYDROLASE from Mycobacterium tuberculosis (406 aa), FASTA scores: opt: 176, E(): 0.0014, (25.7% identity in 218 aa overlap). Q7TVV1 No conserved hypotheticals Rv3717 NC_002945.3 Mycobrowser_v2 CDS 4099766 4101178 . + 0 Mb3746 conserved protein Mb3746, -, len: 470 aa. Equivalent to Rv3719, len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 470 aa overlap). Conserved hypothetical protein, equivalent to O69516|ML2333|MLCB2407.17c HYPOTHETICAL 51.8 KDA PROTEIN from Mycobacterium leprae (459 aa), FASTA scores: opt: 2593, E(): 7.8e-161, (82.75% identity in 458 aa overlap). Also some similarity to Q9CU63|5830417J06RIK HYPOTHETICAL PROTEIN (FRAGMENT) from Mus musculus (Mouse) (479 aa) FASTA scores: opt: 454, E(): 6.1e-22, (27.1% identity in 413 aa overlap); Q9HBA8 SELADIN-1 (UNKNOWN) from Homo sapiens (Human) (516 aa),FASTA scores: opt: 444, E(): 2.9e-21, (26.7% identity in 412 aa overlap); O17397|DIMH_CAEEL|F52H2.6 DIMINUTO-LIKE PROTEIN from Caenorhabditis elegans (525 aa), FASTA scores: opt: 419, E(): 1.2e-19, (24.4% identity in 434 aa overlap); Q39085|DIM_ARATH|DWF1 CELL ELONGATION PROTEIN DIMINUTO from Arabidopsis thaliana (Mouse-ear cress) (561 aa) FASTA scores: opt: 318, E(): 4.8e-13, (24.6% identity in 455 aa overlap); etc. Also some similarity to M. tuberculosis hypothetical proteins P72056|Rv3790|MTCY13D12.24 (461 aa) FASTA scores: opt: 174, E(): 0.00016; (25.1% identity in 426 aa overlap); and Q50685|Rv2280|MTCY339_30c (459 aa). Q7TVU9 No conserved hypotheticals Rv3719 NC_002945.3 Mycobrowser_v2 CDS 4200836 4201735 . - 0 Mb3833c fbpD SECRETED MPT51/MPB51 ANTIGEN PROTEIN FBPD (MPT51/MPB51 ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) (85C) Mb3833c, fbpD, len: 299 aa. Equivalent to Rv3803c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). fbpD (alternate gene names: mpt51, mpb51, fbpC1), secreted MPB51/MPT51 antigen protein (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below),identical to Q48923|MPT51|MPB51 ANTIGEN PRECURSOR from Mycobacterium bovis (299 aa), FASTA scores: opt: 2093,E(): 1.5e-112, (100.0% identity in 299 aa overlap) (see second citation below); and highly similar to other Mycobacterial antigen precursors e.g. Q05868|MPT5_MYCLE|MPT51|ML0098 MPT51 ANTIGEN PRECURSOR from Mycobacterium leprae (301 aa), FASTA scores: opt: 1624, E(): 9.8e-86, (77.8% identity in 302 aa overlap); O52972|A85C_MYCAV|FBPC ANTIGEN 85-C PRECURSOR (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium avium (352 aa), FASTA scores: opt: 753, E(): 6.6e-36, (41.5% identity in 315 aa overlap); P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR (FIBRONECTIN-BINDING PROTEIN B) from Mycobacterium kansasii (325 aa), FASTA scores: opt: 574,E(): 1.1e-25, (37.55% identity in 309 aa overlap); P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from Mycobacterium bovis (323 aa), FASTA scores: opt: 572, E(): 1.4e-25, (39.85% identity in 291 aa overlap); etc. Also similar to P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 SECRETED ANTIGEN 85-C (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 751, E(): 8.4e-36, (40.65% identity in 310 aa overlap); P17944|A85A_MYCTU|FBPA|MPT44|Rv3804c|MT3911|MTV026.09c SECRETED ANTIGEN 85-A (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) from Mycobacterium tuberculosis (338 aa), FASTA scores: opt: 592, E(): 1e-26,(39.05% identity in 302 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Note that the secreted protein MPB51 is one of the major proteins in the culture filtrate of Mycobacterium bovis BCG. X2BPV6,P0A4V7 No NC_002945.3 Mycobrowser_v2 CDS 4108881 4110074 . + 0 Mb3753 possible dehydrogenase Mb3753, -, len: 397 aa. Equivalent to Rv3726, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Possible dehydrogenase (EC 1.-.-.-), similar to many e.g. O34788|YDJL DEHYDROGENASE from Bacillus subtilis (346 aa) FASTA scores: opt: 401, E(): 3.4e-17, (29.6% identity in 395 aa overlap); Q59696|ADH 2,3-BUTANEDIOL DEHYDROGENASE (EC 1.1.1.4) from seudomonas putida (362 aa), FASTA scores: opt: 326, E(): 1.3e-12, (29.45% identity in 387 aa overlap); AAG59541|YJJN PUTATIVE OXIDOREDUCTASE from Escherichia coli strain EDL933 (345 aa), FASTA scores: opt: 325, E(): 1.5e-12, (30.85% identity in 256 aa overlap); Q9HWM8|PA4153 2,3-BUTANEDIOL DEHYDROGENASE from Pseudomonas aeruginosa (363 aa), FASTA scores: opt: 324,E(): 1.8e-12, (30.5% identity in 387 aa overlap); etc. Q7TVU3 No intermediary metabolism and respiration Rv3726 NC_002945.3 Mycobrowser_v2 CDS 4102455 4104191 . - 0 Mb3748c dnaZX DNA POLYMERASE III (SUBUNIT GAMMA/TAU) DNAZ/X Mb3748c, dnaZX, len: 578 aa. Equivalent to Rv3721c,len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 578 aa overlap). Probable dnaZX, DNA polymerase III gamma (dnaZ) and tau (dnaX) (EC 2.7.7.7),equivalent to O69514|DNAZX|ML2335 DNA POLYMERASE III SUBUNIT GAMMA/TAU from Mycobacterium leprae (611 aa) FASTA scores: opt: 2344, E(): 4.7e-118, (78.75% identity in 602 aa overlap). Also highly similar to many e.g. Q9RKL5|DNAZ from Streptomyces coelicolor (784 aa) FASTA scores: opt: 1755, E(): 1.8e-86, (59.55% identity in 435 aa overlap); Q9KGM4|DNAX|BH0034 from Bacillus halodurans (564 aa),FASTA scores: opt: 946, E(): 2.5e-43, (37.4% identity in 460 aa overlap); P09122|DP3X_BACSU|DNAX|DNAH from Bacillus subtilis (563 aa), FASTA scores: opt: 841, E(): 1e-37,(30.8% identity in 510 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). X2BPN8,P63976 No NC_002945.3 Mycobrowser_v2 CDS 4104281 4105588 . - 0 Mb3749c conserved protein Mb3749c, -, len: 435 aa. Equivalent to Rv3722c,len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 435 aa overlap). Conserved hypothetical protein, equivalent to O69513|MLCB2407.14 (alias Q9CB73|ML2336, 463 aa) HYPOTHETICAL 46.8 KDA PROTEIN from Mycobacterium leprae (426 aa), FASTA scores: opt: 2505, E(): 8.3e-154, (87.25% identity in 424 aa overlap). Also highly similar to Q9RU17|DR1579 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (452 aa), FASTA scores: opt: 1162, E(): 3.1e-67, (44.8% identity in 422 aa overlap); and partially similar to Q9I371|PA1654 PROBABLE AMINOTRANSFERASE from Pseudomonas aeruginosa (388 aa) FASTA scores: opt: 162, E(): 0.0078,(25.85% identity in 348 aa overlap) and other aminotransferases. N-terminus extended since first submission (previously 408 aa). Q7TVU7 No conserved hypotheticals Rv3722c NC_002945.3 Mycobrowser_v2 tRNA 4105805 4105890 . + 0 serV serV tRNA-Ser serV, len: 86 nt. Equivalent to serV, len: 86 nt,from Mycobacterium tuberculosis strain H37RV, (100.0% identity in 86 nt overlap). tRNA-Ser, anticodon gga. No NC_002945.3 Mycobrowser_v2 CDS 4105996 4106760 . + 0 Mb3750 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3750, -, len: 254 aa. Equivalent to Rv3723, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Probable conserved transmembrane protein, with hydrophobic stretches at the N-terminus, and equivalent to O69512|ML2337|MLCB2407.13c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (250 aa), FASTA scores: opt: 1029, E(): 1.2e-44, (64.45% identity in 253 aa overlap). Q7TVU6 No cell wall and cell processes Rv3723 NC_002945.3 Mycobrowser_v2 CDS 4106927 4107628 . + 0 Mb3751 cut5 probable cutinase [second part] cut5b Mb3751, cut5, len: 233 aa. Equivalent to Rv3724A (cut5a) and Rv3724B (cut5b), len: 80 aa and 187 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 67 aa overlap and 100.0% identity in 166 aa overlap). Probable cut5a, truncated cutinase precursor (EC 3.1.1.-),similar to N-terminal end of others e.g. Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 202, E(): 1.5e-06, (56.45% identity in 62 aa overlap); Q9XB09|RVD2-RV1758 PROTEIN (FRAGMENT) from Mycobacterium bovis BCG (143 aa), FASTA scores: opt: 200,E(): 1.5e-06, (61.4% identity in 57 aa overlap); and Q00298|CUTI_BOTCI|CUTA CUTINASE PRECURSOR from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 108, E(): 2.2, (40.4% identity in 52 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 189, E(): 1.2e-05, (58.0% identity in 50 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 172, E(): 0.00015, (59.2% identity in 49 aa overlap); O06793|Rv1758|MTCY28.24|Z95890 HYPOTHETICAL 17.9 KDA PROTEIN (174 aa), FASTA scores: opt: 641, E(): 2.7e-29,(57.2% identity in 166 aa overlap); O06319|Rv3452|MTY13E12.05; and U00015_11 from Mycobaterium leprae. BELONGS TO THE CUTINASE FAMILY. Rest of cutinase ORF continues as Rv3724B|CUT5B, frameshifting could occur near position 4169668. Sequence has been checked but no errors found. Probable cut5b, truncated cutinase (EC 3.1.1.-), similar to C-terminal end of others e.g. Q9XB09|RVD2-RV1758 PROTEIN (FRAGMENT) from Mycobacterium bovis BCG (143 aa) FASTA scores: opt: 335, E(): 3.4e-12,(53.25% identity in 92 aa overlap); Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 251, E(): 2.5e-07, (44.05% identity in 168 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. O06793|Rv1758|MTCY28.24 HYPOTHETICAL 17.9 KDA PROTEIN (174 aa), FASTA scores: opt: 641, E(): 2.5e-29, (57.25% identity in 166 aa overlap); O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN (226 aa), FASTA scores: opt: 385, E(): 7.5e-15, (46.65% identity in 165 aa overlap); O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 307, E(): 1.9e-10, (40.7% identity in 167 aa overlap); Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 261, E(): 6.7e-08, (50.9% identity in 169 aa overlap); etc; and U00015_11 from Mycobacterium lepra. 5'-end of gene is Rv3724A|CUT5A; frameshifting may occur near position 4169668. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product. Q7TVU5 No cell wall and cell processes Rv3724A NC_002945.3 Mycobrowser_v2 CDS 4126745 4127101 . - 0 Mb3765c PPE66 ppe family protein ppe66 Mb3765c, PPE66, len: 118 aa. Equivalent to 3' end of Rv3738c, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 105 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa),FASTA scores: opt: 464, E(): 2.2e-17, (47.05% identity in 338 aa overlap). Probably a continuation of the upstream ORF MTV025.87c. At position 97470-72 a stop codon is present which interrupts a possibly longer ORF, observed in related ORFs MTV012_32 or MTCY21B4_4. The sequence has been checked and no errors were detected. A similar situation, but with a frameshift separating the ORFs is found in MTV012_36/MTV012_35. Sequence similarity is also seen with MTCY251_15; MTCY261_19; MLCB2492_30 from Mycobacterium leprae; MTCY10G2_10; MTY21C12_9; MTCI125_26; MTCY164_36; MTCY6A4_1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 1166 bp leads to the loss of the NH2 part of PPE66 and of Rv3739c compared to its homolog in Mycobacterium tuberculosis strain H37Rv. No NC_002945.3 Mycobrowser_v2 CDS 4107673 4108674 . + 0 Mb3752 possible oxidoreductase Mb3752, -, len: 333 aa. Equivalent to Rv3725, len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Possible reductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa), FASTA scores: opt: 317, E(): 6.1e-11, (30.5% identity in 272 aa overlap); Q9SZB3|F17M5.120|AT4G33360|AAK49584 HYPOTHETICAL 37.9 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (344 aa), FASTA scores: opt: 314, E(): 9.1e-11, (30.35% identity in 267 aa overlap); AAK59445|AT4G33360 PUTATIVE DIHYDROKAEMPFEROL 4-REDUCTASE from Arabidopsis thaliana (Mouse-ear cress) (332 aa), FASTA scores: opt: 313, E(): 1e-10, (30.8% identity in 263 aa overlap); Q9FSC6|CCR CINNAMOYL-COA REDUCTASE (EC 1.2.1.44) from Populus trichocarpa (Western balsam poplar) (338 aa), FASTA scores: opt: 305, E(): 2.9e-10, (30.3% identity in 274 aa overlap); Q9M631 CINNAMOYL CoA REDUCTASE from Populus tremuloides (Quaking aspen) (337 aa), FASTA scores: opt: 291, E(): 1.8e-09, (30.15% identity in 272 aa overlap); P73212|DFRA_SYNY3|LR1706 PUTATIVE DIHYDROFLAVONOL-4-REDUCTASE (EC 1.1.1.219) (DIHYDROKAEMPFEROL 4-REDUCTASE) from Synechocystis sp. strain PCC 6803 (343 aa), FASTA scores: opt: 278, E(): 1e-08, (29.35% identity in 259 aa overlap); etc. Also some similarity to proteins from Mycobacterium tuberculosis e.g. P96816|Rv0139|MTCI5.13 HYPOTHETICAL PROTEIN (340 aa) FASTA scores: opt: 234, E(): 3.2e-06, (28.25% identity in 269 aa overlap); and O06373|galE1|Rv3634c|MTCY15C10.18 PROBABLE UDP-GLUCOSE 4-EPIMERASE (314 aa) (27.3% identity in 194 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-a) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa). Q7TVU4 No intermediary metabolism and respiration Rv3725 NC_002945.3 Mycobrowser_v2 CDS 4110415 4112223 . + 0 Mb3754 POSSIBLE OXIDOREDUCTASE Mb3754, -, len: 602 aa. Equivalent to Rv3727, len: 602 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 602 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to several plants phytoene dehydrogenases/desaturases (EC 1.3.-.-) e.g. Q9HSE1|CRTI3|VNG0277G PHYTOENE DEHYDROGENASE from Halobacterium sp. strain NRC-1 (541 aa), FASTA scores: opt: 299, E(): 1.1e-10, (29.85% identity in 576 aa overlap); Q9FZL6|CITPDS1 PHYTOENE DESATURASE from Citrus unshiu (Satsuma orange) (553 aa), FASTA scores: opt: 164,E(): 0.018, (24.2% identity in 434 aa overlap); Q07356|CRTI_ARATH|PDS|AT4G14210|DL3145c PHYTOENE DEHYDROGENASE PRECURSOR from Arabidopsis thaliana (Mouse-ear cress) (566 aa), FASTA scores: opt: 163, E(): 0.021, (23.95% identity in 434 aa overlap); etc. N-terminal end similar to O69871|SC1C3.29 PUTATIVE PROTOPORPHYRINOGEN OXIDASE (FRAGMENT) from Streptomyces coelicolor (61 aa), FASTA scores: opt: 154, E(): 0.012,(60.45% identity in 43 aa overlap). The region between aa 155-310 is highly similar to Q49778|B2126_C1_169 from Mycobacterium leprae (159 aa), FASTA scores: opt: 437,E(): 1.5e-19, (46.6% identity in 161 aa overlap). And the region between aa 462-546 is highly similar to the N-terminal end of Q50003|U1764T from Mycobacterium leprae (155 aa), FASTA scores: opt: 277, E(): 8.3e-10, (57.65% identity in 85 aa overlap). Q7TVU2 No intermediary metabolism and respiration Rv3727 NC_002945.3 Mycobrowser_v2 CDS 4112333 4115530 . + 0 Mb3755 PROBABLE CONSERVED TWO-DOMAIN MEMBRANE PROTEIN Mb3755, -, len: 1065 aa. Equivalent to Rv3728, len: 1065 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1065 aa overlap). Probable conserved transmembrane protein organised into two domains. Domain comprising the first ~510 aa residues is similar to various multidrug resistance and efflux proteins and contains sugar transport protein signature 1 (PS00216). Domain corresponding to the last 550 aa residues contains cyclic nucleotide-binding domain signature 2 (PS00889) and is very similar to Q50733|YP65_MYCTU|Rv2565|MT2641|MTCY9C4.03c hypothetical 62.1 kDa protein from Mycobacterium tuberculosis (31.0% identity in 546 aa overlap). Highly similar to O05884|Rv3239c|MTCY20B11.14c PROBABLE TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis (1048 aa) FASTA scores: opt: 4328, E(): 5e-201, (64.15% identity in 1046 aa overlap). N-terminal end similar to P71879|Rv2333c|MTCY3G12.01|MTCY98.02c (537 aa); P71836|Rv0783c|MTCY369.27c (540 aa); and O07753|Rv1877|MTCY180.41c (687 aa). SEEMS BELONG TO THE SUGAR TRANSPORTER FAMILY. Possibly member of major facilitator superfamily (MFS). Q7TVU1 No cell wall and cell processes Rv3728 NC_002945.3 Mycobrowser_v2 CDS 4115745 4118075 . + 0 Mb3756 POSSIBLE TRANSFERASE Mb3756, -, len: 776 aa. Equivalent to Rv3729, len: 776 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 776 aa overlap). Conserved hypothetical protein, possible transferase (EC 2.-.-.-), similar to several hypothetical proteins and various transferases e.g. O26919|MTH831 MOLYBDENUM COFACTOR BIOSYNTHESIS MOAA HOMOLOG from Methanobacterium thermoautotrophicum (497 aa), FASTA scores: opt: 697, E(): 4.8e-34, (30.7% identity in 492 aa overlap); Q58036|Y619_METJA|MJ0619 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (506 aa), FASTA scores: opt: 670, E(): 2e-32, (30.6% identity in 497 aa overlap); O27968|AF2316 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (518 aa), FASTA scores: opt: 477, E(): 6.4e-21, (29.4% identity in 500 aa overlap); BAB60102|TVG0985801 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Thermoplasma volcanium (606 aa), FASTA scores: opt: 402, E(): 2.1e-16, (28.1% identity in 509 aa overlap); etc. C-terminus similar to methyltransferases e.g. Q9S0N6|AVED C5-O-METHYLTRANSFERASE from Streptomyces avermitilis (283 aa), FASTA scores: opt: 298, E(): 1.9e-10, (31.5% identity in 292 aa overlap). Also similar to the Mycobacterium tuberculosis proteins P71673|YE05_MYCTU|Rv1405c|MT1449|MTCY21B4.22c (274 aa); and Q50584|Rv1523|MTCY19G5.05c. Q7TVU0 No intermediary metabolism and respiration Rv3729 NC_002945.3 Mycobrowser_v2 CDS 4118140 4119180 . - 0 Mb3757c CONSERVED HYPOTHETICAL PROTEIN Mb3757c, -, len: 346 aa. Equivalent to Rv3730c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Conserved hypothetical protein, highly similar to Q9XAM1|SC4C6.19 HYPOTHETICAL 38.5 KDA PROTEIN from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1313, E(): 2.2e-75, (59.25% identity in 336 aa overlap); and similar to C-terminal end of PUTATIVE ATP-DEPENDENT DNA LIGASES e.g. BAB49297|MLL2077 from Rhizobium loti (Mesorhizobium loti) (833 aa), FASTA scores: opt: 550, E(): 5.3e-27, (31.3% identity in 294 aa overlap); and BAB54816|MLL9625 from Rhizobium loti (Mesorhizobium loti) plasmid pMLb (883 aa) FASTA scores: opt: 492, E(): 2.5e-23, (33.7% identity in 291 aa overlap); etc. Also similar to the hypothetical proteins e.g. Q9ZC15|SC1E6.07 HYPOTHETICAL 34.9 KDA PROTEIN from Streptomyces coelicolor (319 aa) FASTA scores: opt: 537, E(): 1.5e-26, (34.95% identity in 292 aa overlap); Q9XAF7|SC6G9.25 HYPOTHETICAL 32.1 KDA PROTEIN from Streptomyces coelicolor (293 aa), FASTA scores: opt: 474, E(): 1.3e-22, (33.75% identity in 302 aa overlap); etc. Also highly similar to P95226|Rv0269c|MTCY06A4.13c HYPOTHETICAL 44.0 KDA PROTEIN from Mycobacterium tuberculosis (397 aa), FASTA scores: opt: 940, E(): 7.7e-52, (50.3% identity in 312 aa overlap). Q7TVT9 No conserved hypotheticals Rv3730c NC_002945.3 Mycobrowser_v2 CDS 4134500 4134892 . - 0 Mb3776c possible excisionase Mb3776c, -, len: 130 aa. Equivalent to Rv3750c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Possible excisionase,similar to others e.g. Q9LCU5 PUTATIVE EXCISIONASE from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 297, E(): 1.2e-12, (40.35% identity in 114 aa overlap); O85865 PUTATIVE EXCISIONASE from Sphingomonas aromaticivorans plasmid pNL1 (152 aa), FASTA scores: opt: 223, E(): 7.3e-08, (39.15% identity in 97 aa overlap); Q9XBH1|XIS EXCISIONASE from Bacteroides fragilis (124 aa) FASTA scores: opt: 128, E(): 0.1, (30.7% identity in 88 aa overlap); etc. Also some similarity to transcriptional regulators. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c (114 aa) FASTA scores: opt: 224, E(): 4.9e-08, (42.7% identity in 82 aa overlap). Contains helix-turn-helix motif at aa 55-76 (Score 1925,+5.74 SD). Q7TVS3 No insertion seqs and phages Rv3750c NC_002945.3 Mycobrowser_v2 CDS 4119218 4120294 . + 0 Mb3758 ligC possible atp-dependent dna ligase ligc (polydeoxyribonucleotide synthase [atp]) (polynucleotide ligase [atp]) (sealase) (dna repair protein) (dna joinase) Mb3758, ligC, len: 358 aa. Equivalent to Rv3731,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 358 aa overlap). Possible ligC, DNA ligase ATP-dependent (EC 6.5.1.1), similar to numerous archaebacterial and eukaryotic polynucleotide DNA ligases e.g. Q9XAM3|SC4C6.17c from Streptomyces coelicolor (355 aa), FASTA scores: opt: 1429, E(): 1.7e-82, (60.4% identity in 361 aa overlap); BAB54870|MLL9685 from Rhizobium loti (Mesorhizobium loti) plasmid pMLb (337 aa),FASTA scores: opt: 667, E(): 1.2e-34, (40.35% identity in 347 aa overlap); Q9HH07|DNLI_THEFM|LIG from Thermococcus fumicolans (559 aa), FASTA scores: opt: 335, E(): 1.4e-13,(27.25% identity in 330 aa overlap); O59288|DNLI_PYRHO from Pyrococcus horikoshii (559 aa), FASTA scores: opt: 307, E(): 8e-12, (26.85% identity in 272 aa overlap); etc. Also similar to Rv3062|MTCY22D7_19c|LIGB PROBABLE DNA LIGASE from Mycobacterium tuberculosis (507 aa), FASTA score: (30.3% identity in 356 aa overlap). SEEMS TO BELONG TO THE ATP-DEPENDENT DNA LIGASE FAMILY. Q7TTR3 No information pathways Rv3731 NC_002945.3 Mycobrowser_v2 CDS 4120394 4121452 . + 0 Mb3759 conserved protein Mb3759, -, len: 352 aa. Equivalent to Rv3732, len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein. The region between aa 175-352 is highly similar to the region between aa 72-257 of Q9KH39 HYPOTHETICAL 55.5 KDA PROTEIN from Mycobacterium smegmatis (511 aa), FASTA scores: opt: 1122, E(): 7.3e-63, (98.85% identity in 176 aa overlap). Also shows some similarity with Q55304 HYPOTHETICALK PROTEIN from Synechocystis sp. strain PCC 6803 (387 aa), FASTA scores: opt: 201, E(): 2.7e-05, (27.1% identity in 251 aa overlap); and P74254|SLR1173 HYPOTHETICAL 52.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (463 aa), FASTA scores: opt: 201, E(): 3.1e-05, (27.1% identity in 251 aa overlap). Also slightly similar to MTCY01B2_21 and DPO1_MYCTU DNA POLYMERASE I. Q7TVT8 No conserved hypotheticals Rv3732 NC_002945.3 Mycobrowser_v2 CDS 4121472 4121972 . - 0 Mb3760c CONSERVED HYPOTHETICAL PROTEIN Mb3760c, -, len: 166 aa. Equivalent to Rv3733c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, highly similar to Q9FCB0|2SCG58.03 PUTATIVE MUTT-LIKE PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 541, E(): 7.2e-29, (52.7% identity in 148 aa overlap); and BAB49143|MLR1881 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (156 aa), FASTA scores: opt: 526, E(): 7.2e-28,(52.65% identity in 150 aa overlap). Q7TVT7 No conserved hypotheticals Rv3733c NC_002945.3 Mycobrowser_v2 CDS 4136715 4137620 . + 0 Mb3780 tyrA PREPHENATE DEHYDROGENASE TYRA (PDH) (HYDROXYPHENYLPYRUVATE SYNTHASE) Mb3780, tyrA, len: 301 aa. Equivalent to Rv3754,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Probable tyrA,prephenate dehydrogenase (EC 1.3.1.12), equivalent, but shorter 27 aa, to Q9CB34|ML2472 POSSIBLE PREPHENATE DEHYDROGENASE from Mycobacterium leprae (327 aa) FASTA scores: opt: 1600, E(): 1.6e-89, (80.0% identity in 300 aa overlap). Also similar to many pephenate dehydrogenases e.g. Q9RND8|TYRA from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (299 aa), FASTA scores: opt: 345, E(): 9.7e-14, (32.85% identity in 271 aa overlap); Q9RVA7|DR1122 from Deinococcus radiodurans (372 aa) FASTA scores: opt: 341, E(): 2e-13, (35.65% identity in 216 aa overlap); P20692|TYRA_BACSU from Bacillus subtilis (372 aa), FASTA scores: opt: 314, E(): 8.6e-12, (27.75% identity in 263 aa overlap); etc. Also similar to Q04983|TYRC_ZYMMO TYRC PROTEIN [INCLUDES: CYCLOHEXADIENYL DEHYDROGENASE AND PREPHENATE DEHYDROGENASE ACTIVITIES] from Zymomonas mobilis (293 aa), FASTA scores: opt: 290,E(): 2e-10, (30.15% identity in 239 aa overlap). Equivalent to AAK48225 from Mycobacterium tuberculosis strain CDC1551 (323 aa) but shorter 22 aa. Q7TVR9 No intermediary metabolism and respiration Rv3754 NC_002945.3 Mycobrowser_v2 CDS 4121986 4123350 . - 0 Mb3761c tgs2 putative triacylglycerol synthase (diacylglycerol acyltransferase) tgs2 Mb3761c, -, len: 454 aa. Equivalent to Rv3734c,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 454 aa overlap). Hypothetical protein,highly similar to O69707|Y1E0_MYCTU|Rv3740c|MT3848|MTV025.088c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (448 aa), FASTA scores: opt: 1917, E(): 1.3e-111, (61.4% identity in 451 aa overlap); and similar to many other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P71694|YE43_MYCTU|Rv1425|MT1468|MTCY21B4.43|MTCY493.29c (459 aa), FASTA scores: opt: 824, E(): 1.1e-43, (36.5% identity in 460 aa overlap); Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 766, E(): 4.1e-40, (36.4% identity in 453 aa overlap); etc. Also similar to Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 331, E(): 4.3e-13, (32.9% identity in 468 aa overlap); and Q9X7A8|ML1244|MLCB1610.05 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 296, E(): 7e-11, (28.35% identity in 413 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Start site chosen by homology, but may extend further upstream. X2BPF5,P67211 No lipid metabolism Rv3734c NC_002945.3 Mycobrowser_v2 CDS 4132465 4132800 . - 0 Mb3772c PE34 probable pe family protein pe34 (pe family-related protein) Mb3772c, PE34, len: 111 aa. Equivalent to Rv3746c,len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Probable member of the Mycobacterium tuberculosis PE family, but without the glycine-rich C-terminal part, similar to N-termini of many e.g. O69737|Rv3872|MTV027.07 (99 aa) FASTA scores: opt: 306, E(): 1e-13, (50.5% identity in 99 aa overlap); O53215|Rv2490c|MTV008.46 (1660 aa) FASTA scores: opt: 125,E(): 0.99, (34.25% identity in 111 aa overlap). Also weakly similar to MTV008_46; MTCI418B_6; MTCY130_1; MTY25D10_11; MTCY1A11_25; MTCY21B4_13; MTCY21B4_27; MTCY493_2; MTCY28_25; etc. Q7TVS7 No NC_002945.3 Mycobrowser_v2 CDS 4123549 4124037 . + 0 Mb3762 CONSERVED HYPOTHETICAL PROTEIN Mb3762, -, len: 162 aa. Equivalent to Rv3735, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Conserved hypothetical protein, highly similar to several bacterial hypothetical proteins e.g. Q9UX41|ORF-C09_016|SSO0651|AAK40956 from Sulfolobus solfataricus (163 aa), FASTA scores: opt: 627, E(): 1.2e-34, (55.9% identity in 161 aa overlap); O26795|MTH699 from Methanobacterium thermoautotrophicum (168 aa), FASTA scores: opt: 616, E(): 6.7e-34, (56.1% identity in 155 aa overlap); |Q9Y9J9|APE2289 from Aeropyrum pernix (191 aa),FASTA scores: opt: 591, E(): 3.4e-32, (54.65% identity in 161 aa overlap) ; etc. Contains PS00435 Peroxidases proximal heme-ligand signature. Q7TVT6 No conserved hypotheticals Rv3735 NC_002945.3 Mycobrowser_v2 CDS 4311909 4314410 . - 0 Mb3924c eccc2 POSSIBLE CONSERVED MEMBRANE PROTEIN [FIRST PART] Mb3924c, -, len: 833 aa. Equivalent to 5' end of Rv3894c, len: 1396 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 771 aa overlap). Possible conserved membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa),FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 537,E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 523, E(): 8.6e-23, (31.65% identity in 1412 aa overlap). Also similar to various proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 973, E(): 2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23,(24.95% identity in 1450 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),FASTA scores: opt: 444, E(): 4.1e-18, (22.5% identity in 1346 aa overlap); etc. Also similar to AAK46103|MT1833 FTSK/SPOIIIE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt: 769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap); and other hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391 aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa overlap) (similarity only with C-terminal end); etc. Contains two possible (PS00017) ATP/GTP-binding sites (P-loop) in central portion. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts, Mb3923c and Mb3924c. Q7TVE6 No NC_002945.3 Mycobrowser_v2 CDS 4124094 4125155 . + 0 Mb3763 TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARAC/XYLS-FAMILY) Mb3763, -, len: 353 aa. Equivalent to Rv3736, len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 353 aa overlap). Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 HYPOTHETICAL 35.4 KDA PROTEIN from Bradyrhizobium japonicum (318 aa), FASTA scores: opt: 438,E(): 2e-20, (29.4% identity in 306 aa overlap); Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 395,E(): 1.1e-17, (30.3% identity in 320 aa overlap); Q9HTN1|PA5324 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (356 aa), FASTA scores: opt: 313,E(): 1.8e-12, (25.85% identity in 329 aa overlap); Q9Z3Y6|PHBR TRANSCRIPTIONAL REGULATOR PHBR from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 271,E(): 8.3e-10, (22.95% identity in 357 aa overlap); etc. Also highly similar to Q06861|VIRS_MYCTU|Rv3082c|MTV013.03c POSSIBLE VIRULENCE-REGULATING PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 656, E(): 3.7e-34, (36.95% identity in 333 aa overlap); and similar to other hypothetical mycobacterial proteins e.g. P71663|YD95_MYCTU|Rv1395|MT1440|MTCY21B4.12 (344 aa). Contains helix-turn-helix motif at aa 245-266 (Score 1140,+3.07 SD). SEEMS BELONG TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TVT5 No regulatory proteins Rv3736 NC_002945.3 Mycobrowser_v2 CDS 4125159 4126748 . + 0 Mb3764 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3764, -, len: 529 aa. Equivalent to Rv3737, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 529 aa overlap). Probable conserved transmembrane protein, similar to others and also some hypothetical proteins e.g. AAK61331|THRE THREONINE EXPORT CARRIER from Corynebacterium glutamicum (Brevibacterium flavum) (489 aa), FASTA scores: opt: 773, E(): 1.8e-36,(37.25% identity in 424 aa overlap); Q9X8J0|SCE9.17 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (578 aa), FASTA scores: opt: 642, E(): 5.4e-29, (31.6% identity in 481 aa overlap) (shorter 119 aa at N-terminus); Q9CJU6|PM1895 HYPOTHETICAL PROTEIN from Pasteurella multocida (262 aa), FASTA scores: opt: 233,E(): 4.1e-06, (25.0% identity in 256 aa overlap); Q9S267|SCI30A.06 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (297 aa), FASTA scores: opt: 163,E(): 0.042, (29.65% identity in 263 aa overlap); etc. Also partially similar to O05435|Rv3910|MTCY15F10.01c|MTV028.01 HYPOTHETICAL 123.6 KDA PROTEIN from Mycobacterium tuberculosis (1184 aa) (34.4% identity in 125 aa overlap). Q7TVT4 No cell wall and cell processes Rv3737 NC_002945.3 Mycobrowser_v2 CDS 4127127 4128473 . - 0 Mb3766c possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb3766c, -, len: 448 aa. Equivalent to Rv3740c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 448 aa overlap). Conserved hypothetical protein, highly similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa) FASTA scores: opt: 1917, E(): 2.3e-112, (61.4% identity in 451 aa overlap); Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 858, E(): 3.4e-46, (37.4% identity in 460 aa overlap); Q10554|Y895_MYCTU|Rv0895|MT0919|MTCY31.23 (505 aa), FASTA scores: opt: 767, E(): 1.9e-40, (44.3% identity in 467 aa overlap); MTCY31_25; MTCY28_26; MTCY493_29; MTCY21B4_43; MTCY8D5_16; MTCY3A2_28; MTV013_8; MTY13E12_33; MTV013_9; MTY20B11_9; etc. Also similar to Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 319,E(): 1.7e-12, (30.9% identity in 453 aa overlap). Q7TVT3 No lipid metabolism Rv3740c NC_002945.3 Mycobrowser_v2 CDS 4135168 4135383 . + 0 Mb3777 probable integrase (fragment) Mb3777, -, len: 71 aa. Equivalent to Rv3751, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Probable integrase (fragment), similar to part of many e.g. Q48908 INTEGRASE (FRAGMENT) from Mycobacterium paratuberculosis (191 aa),FASTA scores: opt: 206, E(): 5.5e-08, (57.65% identity in 59 aa overlap); Q9ZWV7|INT INTEGRASE from Corynephage 304L (395 aa), FASTA scores: opt: 156, E(): 0.00036, (45.75% identity in 59 aa overlap); Q9K722|BH3551 INTEGRASE (PHAGE-RELATED PROTEIN) from Bacillus halodurans (378 aa),FASTA scores: opt: 151, E(): 0.00079, (46.15% identity in 52 aa overlap); etc. Also similarity with various conjugative transposons. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71903|Rv2309c|MTCY3G12.25 (151 aa), FASTA scores: opt: 193, E(): 3.8e-07, (50.85% identity in 59 aa overlap); O53403|Rv1055|MTV017.08 (78 aa), FASTA scores: opt: 171,E(): 7.8e-06, (54.15% identity in 48 aa overlap); etc. Q7TVS2 No insertion seqs and phages Rv3751 NC_002945.3 Mycobrowser_v2 tRNA 4135425 4135511 . - 0 serX serX tRNA-Ser serX, len: 87 nt. Equivalent to serX, len: 87 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 87 nt overlap). tRNA-Ser, anticodon cga. No NC_002945.3 Mycobrowser_v2 CDS 4128473 4129147 . - 0 Mb3767c POSSIBLE OXIDOREDUCTASE Mb3767c, -, len: 224 aa. Equivalent to Rv3741c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible oxidoreductase, probably combines with product of upstream ORF MTV025.090c to form a functional monooxygenase (EC 1.-.-.-), highly similar to C-terminal end of various oxidoreductases e.g. Q9APW3 AROMATIC-RING HYROXYLASE from Pseudomonas aeruginosa (508 aa), FASTA scores: opt: 549,E(): 5.9e-28, (56.1% identity in 155 aa overlap); Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 487,E(): 5.6e-24, (39.55% identity in 225 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 460, E(): 4.7e-22, (38.5% identity in 226 aa overlap); etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN (489 aa), FASTA scores: opt: 542, E(): 1.6e-27, (50.0% identity in 162 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa), FASTA scores: opt: 462,E(): 2.2e-22, (37.15% identity in 226 aa overlap); O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa), FASTA scores: opt: 462, E(): 2.2e-22, (45.65% identity in 173 aa overlap); etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in upstream ORF (MTV025.090c) after a gap of ~100 aa. Q7TVT2 No intermediary metabolism and respiration Rv3741c NC_002945.3 Mycobrowser_v2 CDS 4129144 4129539 . - 0 Mb3768c POSSIBLE OXIDOREDUCTASE Mb3768c, -, len: 131 aa. Equivalent to Rv3742c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Possible oxidoreductase, probably combines with product of downstream ORF MTV025.090c to form a functional monooxygenase (EC 1.-.-.-), highly similar to N-terminal end of various oxidoreductases e.g. Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 170, E(): 0.00048,(47.55% identity in 103 aa overlap); Q9APW3 AROMATIC-RING HYROXYLASE from Pseudomonas aeruginosa (508 aa) FASTA scores: opt: 160, E(): 0.0022, (50.55% identity in 87 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 153,E(): 0.0097, (45.45% identity in 88 aa overlap); etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN (489 aa), FASTA scores: opt: 140, E(): 0.044, (37.1% identity in 132 aa overlap); O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa) FASTA scores: opt: 133, E(): 0.13,(43.05% identity in 79 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa),FASTA scores: opt: 110, E(): 4.1, (42.85% identity in 77 aa overlap); etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in downstream ORF (MTV025.089c) after a gap of ~100 aa. Q7TVT1 No intermediary metabolism and respiration Rv3742c NC_002945.3 Mycobrowser_v2 CDS 4129685 4131667 . - 0 Mb3769c ctpJ probable cation transporter p-type atpase ctpj Mb3769c, ctpJ, len: 660 aa. Equivalent to Rv3743c,len: 660 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 660 aa overlap). Probable ctpJ,cation-transporting P-type ATPase (EC 3.6.1.-),transmembrane protein highly similar to others e.g. Q9ZBF3|SC9B5.27 PUTATIVE CATION-TRANSPORTING ATPASE from Streptomyces coelicolor (638 aa), FASTA scores: opt: 1635,E(): 2.5e-86, (62.25% identity in 63.95 aa overlap); Q59997|CADA|SLR0797 CADMIUM-TRANSPORTING ATPASE from Synechocystis sp. strain PCC 6803 (642 aa), FASTA scores: opt: 1474, E(): 4.3e-77, (42.4% identity in 604 aa overlap); P30336|CADA_BACFI PROBABLE CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa), FASTA scores: opt: 1327, E(): 1.3e-68, (36.6% identity in 626 aa overlap); etc. Also highly similar to O53160|CTPD_MYCTU|Rv1469|MT1515|MTV007.16 PROBABLE CATION-TRANSPORTING P-TYPE ATPASE D from Mycobacterium tuberculosis (657 aa), FASTA scores: opt: 1845, E(): 2.3e-98, (55.85% identity in 650 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site and PS01229 Hypothetical family signature 2. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). Q7TVT0 No NC_002945.3 Mycobrowser_v2 CDS 4133923 4134432 . - 0 Mb3775c CONSERVED HYPOTHETICAL PROTEIN Mb3775c, -, len: 169 aa. Equivalent to Rv3749c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Hypothetical protein,showing some similarity with O85864 HYPOTHETICAL 21.4 KDA PROTEIN from Sphingomonas aromaticivorans plasmid pNL1 (196 aa), FASTA scores: opt: 148, E(): 0.011, (32.7% identity in 104 aa overlap); Q9LCU6 HYPOTHETICAL 21.2 KDA PROTEIN from Arthrobacter sp. TM1 (192 aa), FASTA scores: opt: 125, E(): 0.35, (31.5% identity in 92 aa overlap); Q9L631|SPCB MYO-INOSITOL-2-DEHYDROGENASE from Streptomyces spectabilis (374 aa); Q9WJP8|PRE-S1 PRE-S1 PROTEIN (FRAGMENT) from Hepatitis B virus (88 aa); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Q7TVS4 No conserved hypotheticals Rv3749c NC_002945.3 Mycobrowser_v2 CDS 4135541 4135999 . - 0 Mb3778c POSSIBLE CYTIDINE/DEOXYCYTIDYLATE DEAMINASE Mb3778c, -, len: 152 aa. Equivalent to Rv3752c,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Probable cytidine/deoxycytidylate deaminase (EC 3.5.4.-),equivalent to Q9CB32|ML2474 POSSIBLE CYTIDINE/DEOXYCYTIDYLATE DEAMINASE from Mycobacterium leprae (171 aa), FASTA scores: opt: 890, E(): 1.6e-50,(88.1% identity in 151 aa overlap). Also highly similar to other deaminases and hypothetical proteins e.g. Q9AK79|2SCD60.04c PUTATIVE DEAMINASE from Streptomyces coelicolor (143 aa), FASTA scores: opt: 559, E(): 2.9e-29,(66.45% identity in 146 aa overlap); Q9F9W7 CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa) FASTA scores: opt: 512, E(): 3.1e-26, (54.85% identity in 144 aa overlap); P21335|YAAJ_BACSU HYPOTHETICAL 17.8 KDA PROTEIN from Bacillus subtilis (161 aa), FASTA scores: opt: 425,E(): 1.4e-20, (47.7% identity in 151 aa overlap); AAK74212|SP0020 CYTIDINE/DEOXYCYTIDYLATE DEAMINASE FAMILY PROTEIN from Streptococcus pneumoniae (155 aa), FASTA scores: opt: 401, E(): 4.7e-19, (46.25% identity in 147 aa overlap); P30134|YFHC_ECOLI|B2559 HYPOTHETICAL 20.0 KDA PROTEIN from Escherichia coli strain K12 (178 aa), FASTA scores: opt: 397, E(): 9.5e-19, (47.0% identity in 149 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. Q7TVS1 No intermediary metabolism and respiration Rv3752c NC_002945.3 Mycobrowser_v2 CDS 4136015 4136536 . - 0 Mb3779c conserved protein Mb3779c, -, len: 173 aa. Equivalent to Rv3753c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical protein, only equivalent to Q9CB33|ML2473 HYPOTHETICAL PROTEIN from Mycobacterium leprae (159 aa) FASTA scores: opt: 920 E(): 1.4e-52,, (88.6% identity in 158 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv (173 aa versus 166 aa). Q7TVS0 No conserved hypotheticals Rv3753c NC_002945.3 Mycobrowser_v2 CDS 4149290 4150234 . - 0 Mb3793c possible s-adenosylmethionine-dependent methyltransferase Mb3793c, -, len: 314 aa. Equivalent to Rv3767c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96823|Rv0146|MTCI5.20 HYPOTHETICAL 34.0 KDA PROTEIN (310 aa), FASTA scores: opt: 909, E(): 5.3e-50, (48.1% identity in 316 aa overlap); O53686|Rv0281|MTV035.09 (302 aa),FASTA scores: opt: 802, E(): 2.8e-43, (45.2% identity in 314 aa overlap); Q50726|YX99_MYCTU|Rv3399|MT3507|MTCY78.29c (348 aa), FASTA scores: opt: 796, E(): 7.6e-43, (45.35% identity in 302 aa overlap); MTCY78_30; MTCY31_23; MTCY210_45; MTCY4C12_14; MTY13D12_21, MTCI5_19; MTCY180_22; etc. Contains probable N-terminal signal sequence X2BPS7,Q7TVQ7 No lipid metabolism Rv3767c NC_002945.3 Mycobrowser_v2 CDS 4137583 4138182 . - 0 Mb3781c conserved protein Mb3781c, -, len: 199 aa. Equivalent to Rv3755c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Conserved hypothetical protein showing similarity to CAC47343|SMC03980 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (196 aa) FASTA scores: opt: 244, E(): 4.1e-09, (30.9% identity in 191 aa overlap); Q9I2B5|PA1994 from Pseudomonas aeruginosa (187 aa), FASTA scores: opt: 226, E(): 6e-08, (29.9% identity in 194 aa overlap); and Q98N73|MLR0268 HYPOTHETICAL PROTEIN (183 aa), FASTA scores: opt: 234, E(): 1.8e-08,(27.05% identity in 185 aa overlap). Q7TVR8 No conserved hypotheticals Rv3755c NC_002945.3 Mycobrowser_v2 CDS 4145341 4145820 . + 0 Mb3789 lpqH 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR LPQH Mb3789, lpqH, len: 159 aa. Equivalent to Rv3763,len: 159 aa, from Mycobacetrium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). lpqH, conserved 19 KDa lipoprotein antigen precursor (see citations below),equivalent to P31502|19KD_MYCIT|MI22 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR (MI22 ANTIGEN) from Mycobacterium intracellulare (162 aa), FASTA scores: opt: 773, E(): 6.2e-35, 75.95(% identity in 162 aa overlap); P46733|19KD_MYCAV 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR from M. avium (161 aa), FASTA scores: opt: 743, E(): 2.5e-33, (72.5% identity in 160 aa overlap); and Q9X7A5|LPQH|ML1966 POSSIBLE LIPOPROTEIN from Mycobacterium leprae FASTA scores: opt: 371, E(): 2.2e-13, (42.6% identity in 162 aa overlap). POSSIBLY ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR. SIMILAR TO OTHER MYCOBACTERIUM 19 KDA ANTIGEN. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. X2BQ19,P0A5J1 No cell wall and cell processes Rv3763 NC_002945.3 Mycobrowser_v2 CDS 4138188 4138907 . - 0 Mb3782c proZ POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROZ Mb3782c, proZ, len: 239 aa. Equivalent to Rv3756c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 402, E(): 1.9e-16, (32.0% identity in 203 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 385, E(): 1.8e-15, (30.2% identity in 222 aa overlap); P39775|O34657|OPUBD|PROZ|OPBD_BACSU CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (226 aa) FASTA scores: opt: 350, E(): 2e-13, (31.75% identity in 208 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY. Q7TVR7 No NC_002945.3 Mycobrowser_v2 CDS 4138904 4139593 . - 0 Mb3783c proW POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROW Mb3783c, proW, len: 229 aa. Equivalent to Rv3757c,len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Possible proW,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58607|Q99RI6|OPUCD|SA2234|SAV2445 OPUCD PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (231 aa) FASTA scores: opt: 364, E(): 7.1e-15, (30.0% identity in 220 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 348, E(): 6.2e-14, (31.05% identity in 206 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 343, E(): 1.2e-13, (30.1% identity in 206 aa overlap); O34742|OPCD_BACSU|OPUCD GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (229 aa) FASTA scores: opt: 337, E(): 2.9e-13, (31.1% identity in 193 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY. Q7TVR6 No NC_002945.3 Mycobrowser_v2 CDS 4150364 4150723 . + 0 Mb3794 unknown protein Mb3794, -, len: 119 aa. Equivalent to Rv3768, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical unknown protein. Q7TVQ6 No conserved hypotheticals Rv3768 NC_002945.3 Mycobrowser_v2 CDS 4150909 4151181 . + 0 Mb3795 HYPOTHETICAL PROTEIN Mb3795, -, len: 90 aa. Equivalent to Rv3769, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein, possible coiled-coil protein. Q7TVQ5 No conserved hypotheticals Rv3769 NC_002945.3 Mycobrowser_v2 CDS 4139581 4140711 . - 0 Mb3784c proV POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV Mb3784c, proV, len: 376 aa. Equivalent to Rv3758c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible proV,osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport, e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER (ATP-BINDING) from Staphylococcus aureus (410 aa), FASTA scores: opt: 816, E(): 8.4e-39, (39.5% identity in 362 aa overlap); O34992|OPCA_BACSU|OPUCA GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (380 aa), FASTA scores: opt: 807, E(): 2.5e-38, (40.55% identity in 333 aa overlap); Q45460|OPBA_BACSU|OPUBA|PROV CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (381 aa), FASTA scores: opt: 801, E(): 5.6e-38,(40.65% identity in 337 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporter family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TVR5 No NC_002945.3 Mycobrowser_v2 CDS 4154884 4155120 . - 0 Mb3802c CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb3802c, -, len: 78 aa. Equivalent to 5' end of Rv3773c, len: 194 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 52 aa overlap). Hypothetical protein, highly similar to C-terminal end of O53773|Rv0576|MTV039.14 POSSIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 575, E(): 8.3e-30, (47.4% identity in 192 aa overlap); and some similarity with other proteins from M. tuberculosis e.g. P71985|Rv1727|MTCY04C12.12 (189 aa) FASTA scores: opt: 176, E(): 0.00022, (31.1% identity in 180 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv3773c into 2 parts,Mb3801c and Mb3802c. Q7TVP8 No NC_002945.3 Mycobrowser_v2 CDS 4140720 4141667 . - 0 Mb3785c proX POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) BINDING LIPOPROTEIN PROX Mb3785c, proX, len: 315 aa. Equivalent to Rv3759c,len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 315 aa overlap). Possible proX,osmoprotectant-binding lipoprotein component of osmoprotectant transport system (see citation below),similar to osmoprotection proteins (proX) involved in glycine betaine/L-proline/choline transport, e.g. AAK79442|CAC1474 PROLINE/GLYCINE BETAINE ABC TRANSPORT SYSTEM PERIPLASMIC COMPONENT from Clostridium acetobutylicum (303 aa), FASTA scores: opt: 308, E(): 1.2e-11, (27.4% identity in 314 aa overlap); Q9X4J2|PROXL|SCE19A.33 PROXL PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 302, E(): 3e-11,(27.2% identity in 327 aa overlap); O29280|AF0982 OSMOPROTECTION PROTEIN (PROX) from Archaeoglobus fulgidus (292 aa), FASTA scores: opt: 235, E(): 3.4e-07, (23.15% identity in 285 aa overlap); etc. Also similar to MTV006_16 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and MLU15180_43 HYPOTHETICAL PROTEIN from Mycobacterium leprae. Equivalent to AAK48230 from Mycobacterium tuberculosis strain CDC1551 (343 aa) but shorter 28 aa. Contains probable N-terminal signal sequence. Q7TVR4 No NC_002945.3 Mycobrowser_v2 CDS 4141832 4142134 . + 0 Mb3786 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb3786, -, len: 100 aa. Equivalent to Rv3760, len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Possible conserved membrane protein, equivalent to Q50094|ML2366|MLCB12.11c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 423, E(): 1.2e-20, (67.7% identity in 99 aa overlap). Also similar with Q9JST1|NMA2149 PUTATIVE INNER MEMBRANE HYPOTHETICAL PROTEIN from Neisseria meningitidis (serogroup A) (104 aa), FASTA scores: opt: 113, E(): 0.95, (33.85% identity in 62 aa overlap); and showing similarity with Q9ZAX7 ABC TRANSPORTER MEMBRANE PROTEIN SUBUNIT from Streptococcus mutans (498 aa), FASTA scores: opt: 108, E(): 6.7, (42.35% identity in 85 aa overlap) (similarity at C-terminus); and P33108|SECY_MICLU PREPROTEIN TRANSLOCASE SECY SUBUNIT from Micrococcus luteus (Micrococcus lysodeikticus) (436 aa),FASTA scores: opt: 106, E(): 8.2, (29.05% identity in 86 aa overlap). Equivalent to AAK48231 from Mycobacterium tuberculosis strain CDC1551 (117 aa) but shorter 17 aa. Q7TVR3 No cell wall and cell processes Rv3760 NC_002945.3 Mycobrowser_v2 CDS 4142156 4143211 . - 0 Mb3787c fadE36 POSSIBLE ACYL-COA DEHYDROGENASE FADE36 Mb3787c, fadE36, len: 351 aa. Equivalent to Rv3761c, len: 351 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 351 aa overlap). Possible fadE36, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases,e.g. Q9APX7|FADE36 FADE36 PROTEIN from Pseudomonas aeruginosa (360 aa), FASTA scores: opt: 147, E(): 0.046,(26.15% identity in 214 aa overlap); part of AAB52261.2|U97002 protein similar to acyl-CoA dehydrogenases and epoxide hydrolases from Caenorhabditis elegans (985 aa), FASTA score: (31.2% identity in 324 aa overlap). C-terminal part is highly similar to Q50095|U1740AK|MLU15183_45 hypothetical protein from Mycobacterium leprae cosmid B174 (122 aa), FASTA scores: opt: 341, E(): 7.3e-15, (57.6% identity in 99 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Q7TVR2 No lipid metabolism Rv3761c NC_002945.3 Mycobrowser_v2 CDS 4143290 4145170 . - 0 Mb3788c possible hydrolase Mb3788c, -, len: 626 aa. Equivalent to Rv3762c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 626 aa overlap). Possible hydrolase (EC 3.-.-.-), highly similar to hypothetical proteins and beta-lactamases (EC 3.5.2.6) e.g. Q9RL04|SC5G9.23 HYPOTHETICAL 70.3 KDA PROTEIN from Streptomyces coelicolor (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083 HYPOTHETICAL 73.2 KDA PROTEIN from Escherichia coli strain K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113,(46.9% identity in 631 aa overlap); Q9A824|CC1540 METALLO-BETA-LACTAMASE FAMILY PROTEIN from Caulobacter crescentus (647 aa), FASTA scores: opt: 1891, E(): 1e-111,(48.55% identity in 628 aa overlap); Q08347|YOL164W CHROMOSOME XV READING FRAME ORF from Saccharomyces cerevisiae (Baker's yeast) (646 aa) FASTA scores: opt: 1829, E(): 8.4e-108, (45.7% identity in 615 aa overlap); Q9I5I9|PA0740 PROBABLE BETA-LACTAMASE from Pseudomonas aeruginosa (658 aa), FASTA scores: opt: 1699, E(): 1.4e-99, (43.15% identity in 630 aa overlap); Q52556|SDSA ALKYL SULFATASE (protein involved in the degradation of sulfate esters of long-chain primaryal cohols e.g. SDS sodium dodecyl sulfate) from Pseudomonas sp (528 aa),FASTA scores: opt: 841, E(): 1.7e-45, (33.7% identity in 534 aa overlap); etc. N-terminual end also highly similar to Q48790|SEPA SEPA PROTEIN (protein implicated in cell separation) from Listeria monocytogenes (391 aa), FASTA scores: opt: 1256, E(): 8.3e-72, (49.6% identity in 363 aa overlap). Also slight similarity to P96253|Rv0407|MTCY22G10.03 HYPOTHETICAL 37.0 KDA PROTEIN from Mycobacterium tuberculosis (336 aa). Q7TVR1 No intermediary metabolism and respiration Rv3762c NC_002945.3 Mycobrowser_v2 CDS 4145876 4147303 . - 0 Mb3790c tcry possible two component sensor kinase tcry Mb3790c, -, len: 475 aa. Equivalent to Rv3764c,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 475 aa overlap). Possible histidine protein kinase (EC 2.7.3.-), part of a two-component regulatory system, similar to others e.g. Q9ADN6|2SC10A7.25 PUTATIVE TWO COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (524 aa), FASTA scores: opt: 1332, E(): 5.4e-70, (49.9% identity in 477 aa overlap); Q9L3C1|KB|CAC42479 PUTATIVE HISTIDINE KINASE from Amycolatopsis mediterranei (469 aa), FASTA scores: opt: 515, E(): 1.4e-22, (36.1% identity in 313 aa overlap); P72560 HISTIDINE PROTEIN KINASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (438 aa), FASTA scores: opt: 480, E(): 1.4e-20, (40.1% identity in 232 aa overlap); P30847|P76401|BAES_ECOLI|B2078 SENSOR PROTEIN from Escherichia coli strain K12 (467 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. P96368|Rv1032c|MTCY10G2.17 (509 aa), FASTA scores: opt: 1007, E(): 4e-51, (43.5% identity in 416 aa overlap); and P71815|Rv0758|MTCY369.03 (485 aa), FASTA scores: opt: 738,E(): 1.6e-35, (28.6% identity in 438 aa overlap). Equivalent to AAK48235 from Mycobacterium tuberculosis strain CDC1551 (506 aa) but shorter 31 aa. Q7TVR0 No regulatory proteins Rv3764c NC_002945.3 Mycobrowser_v2 CDS 4147374 4148078 . - 0 Mb3791c tcrx probable two component transcriptional regulatory protein tcrx Mb3791c, -, len: 234 aa. Equivalent to Rv3765c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable response regulator of a two-component regulatory system, highly similar to others e.g. Q9ADN7|2SC10A7.24 PUTATIVE TWO COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (271 aa), FASTA scores: opt: 1111, E(): 4.8e-63, (72.3% identity in 231 aa overlap); Q9F161 RESPONSE REGULATOR from Corynebacterium glutamicum (Brevibacterium flavum) (232 aa), FASTA scores: opt: 692,E(): 1.2e-36, (46.0% identity in 226 aa overlap); Q9KZU5|SCD84.23c PUTATIVE TWO-COMPONENT SYSTEN RESPONSE REGULATOR from Streptomyces coelicolor (248 aa), FASTA scores: opt: 674, E(): 1.7e-35, (44.05% identity in 236 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50806|Rv1033c|MTCY10G2.16 RESPONSE REGULATOR HOMOLOG (257 aa), FASTA scores: opt: 947, E(): 1e-52, (59.5% identity in 232 aa overlap); P71814|Rv0757|MTCY369.02 PHOP-LIKE PROTEIN (247 aa) FASTA scores: opt: 829, E(): 2.8e-45, (54.65% identity in 225 aa overlap); O53894|Rv0981|MTV044.09 (230 aa), FASTA scores: opt: 662, E(): 9e-35, (44.65% identity in 224 aa overlap); and also similar to MTCY31_34; MTCY19H5_20; MTY13628_5; MTCY20G9_17; and to MLCB57_27 from Mycobacterium leprae; and MBY13627_3 from Mycobacterium bovis BCG. Equivalent to AAK48236 from Mycobacterium tuberculosis strain CDC1551 (286 aa) but shorter 52 aa. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. Q7TVQ9 No regulatory proteins Rv3765c NC_002945.3 Mycobrowser_v2 CDS 4148587 4149276 . + 0 Mb3792 HYPOTHETICAL PROTEIN Mb3792, -, len: 229 aa. Equivalent to Rv3766, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Hypothetical unknown protein. Segment 183 to 229 highly similar to C-terminal part of O06288|Rv3594|MTCY07H7B.28c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 128, E(): 0.92, (46.8% identity in 47 aa overlap). Q7TVQ8 No conserved hypotheticals Rv3766 NC_002945.3 Mycobrowser_v2 CDS 4152698 4153024 . - 0 Mb3799c CONSERVED HYPOTHETICAL PROTEIN Mb3799c, -, len: 108 aa. Equivalent to Rv3771c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Hypothetical protein,highly similar, but shorter 81 aa, to P71640|Rv2811|MTCY16B7.32c HYPOTHETICAL 21.1 KDA PROTEIN from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 469, E(): 2.7e-25, (73.15% identity in 108 aa overlap) Q7TVQ1 No conserved hypotheticals Rv3771c NC_002945.3 Mycobrowser_v2 CDS 4153428 4154489 . + 0 Mb3800 hisC2 PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2 (IMIDAZOLE ACETOL-PHOSPHATE TRANSAMINASE) (IMIDAZOLYLACETOLPHOSPHATE AMINOTRANSFERASE) Mb3800, hisC2, len: 353 aa. Equivalent to Rv3772,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 353 aa overlap). Probable hisC2,histidinol-phosphate aminotransferase (EC 2.6.1.9), highly similar to Q9ZBY8|SCD78.11 PUTATIVE HISTIDINOL-PHOPHATE AMINOTRANSFERASE from Streptomyces coelicolor (359 aa),FASTA scores: opt: 1165, E(): 7.1e-64, (52.55% identity in 356 aa overlap); and similar to many e.g. Q9EYX2 from Gardnerella vaginalis (317 aa) FASTA scores: opt: 814,E(): 1.7e-42, (45.15% identity in 308 aa overlap); Q9CMI7|HISH_1PM0838|HISH from Pasteurella multocida (365 aa), FASTA scores: opt: 701, E(): 1.5e-35, (35.05% identity in 351 aa overlap); O07131|HIS8_METFL|HISC|HISH from Methylobacillus flagellatum (368 aa), FASTA scores: opt: 645, E(): 4e-32, (34.5% identity in 345 aa overlap); etc. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BP56,Q7TVQ0 No NC_002945.3 Mycobrowser_v2 CDS 4154535 4154879 . - 0 Mb3801c CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb3801c, -, len: 114 aa. Equivalent to 3' end of Rv3773c, len: 194 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 114 aa overlap). Hypothetical protein, highly similar to C-terminal end of O53773|Rv0576|MTV039.14 POSSIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 575, E(): 8.3e-30, (47.4% identity in 192 aa overlap); and some similarity with other proteins from Mycobacterium tuberculosis e.g. P71985|Rv1727|MTCY04C12.12 (189 aa) FASTA scores: opt: 176, E(): 0.00022, (31.1% identity in 180 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv3773c in two parts, Mb3802c and Mb3801c. Q7TVP9 No NC_002945.3 Mycobrowser_v2 CDS 4155144 4155968 . + 0 Mb3803 echA21 possible enoyl-coa hydratase echa21 (enoyl hydrase) (unsaturated acyl-coa hydratase) (crotonase) Mb3803, echA21, len: 274 aa. Equivalent to Rv3774,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Possible echA21,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to Q9CD94|ECHA1|ML0120 PUTATIVE ENOYL-COA HYDRATASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1593,E(): 2.2e-92, (88.3% identity in 274 aa overlap). Also similar to others e.g. Q9I2S4|PA1821 from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 761, E(): 2e-40,(42.3% identity in 267 aa overlap); Q9FHR8 from Arabidopsis thaliana (Mouse-ear cress) (278 aa) FASTA scores: opt: 638, E(): 9.9e-33, (39.4% identity in 269 aa overlap); Q9AB78|CC0353 from Caulobacter crescentus (286 aa), FASTA scores: opt: 601, E(): 2.1e-31, (39.25% identity in 266 aa overlap); etc. Q7TVP7 No NC_002945.3 Mycobrowser_v2 CDS 4155980 4157227 . + 0 Mb3804 lipE probable lipase lipe Mb3804, lipE, len: 415 aa. Equivalent to Rv3775,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Probable lipE,hydrolase lipase (EC 3.1.-.-), equivalent to Q9CD95|LIPE|ML0119 PROBABLE HYDROLASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 2418, E(): 6.4e-144,(84.75% identity in 406 aa overlap). Also similar to other esterases e.g. Q9ABH2|CC0255 ESTERASE A from Caulobacter crescentus (374 aa), FASTA scores: opt: 427, E(): 2.4e-19,(28.9% identity in 391 aa overlap); O87861|ESTA ESTERASE A from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 417, E(): 1e-18, (31.0% identity in 361 aa overlap); Q9RK50|SCF12.08 PUTATIVE ESTERASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 385, E(): 1e-16,(31.35% identity in 373 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. P71778|Rv1497|MTCY277.19 HYPOTHETICAL 45.8 KDA PROTEIN (429 aa), FASTA scores: opt: 457, E(): 3.5e-21, (30.4% identity in 395 aa overlap). Q7TVP6 No intermediary metabolism and respiration Rv3775 NC_002945.3 Mycobrowser_v2 CDS 4212844 4214358 . + 0 Mb3842 PE_PGRS62 pe-pgrs family protein pe_pgrs62 Mb3842, PE_PGRS62, len: 504 aa. Equivalent to Rv3812, len: 504 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 504 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. P96828|Rv0151c|MTCI5.25c (588 aa), FASTA scores: opt: 389,E(): 6.2e-14, (29.2% identity in 473 aa overlap); MTCY7H7B_27; MTCY493_24; MTCY441_4; MTCY39_36; MTCY1A11_4; MTCY359_33; MTCY130_10; MTCY98_9; etc. Q7TVM1 No NC_002945.3 Mycobrowser_v2 CDS 4157384 4158943 . + 0 Mb3805 CONSERVED HYPOTHETICAL PROTEIN Mb3805, -, len: 519 aa. Equivalent to Rv3776, len: 519 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 519 aa overlap). Hypothetical protein,highly similar to Q10709|YL00_MYCTU|Rv2100|MTCY49.40 HYPOTHETICAL 58.9 KDA PROTEIN from Mycobacterium tuberculosis (550 aa) FASTA scores: opt: 1646, E(): 1.2e-83, (77.85% identity in 510 aa overlap) (homology from potential start at 7744); and similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O33266|Rv0336|MTCY279.03 (503 aa) FASTA scores: opt: 682, E(): 2.2e-30, (41.65% identity in 497 aa overlap). Q7TVP5 No conserved hypotheticals Rv3776 NC_002945.3 Mycobrowser_v2 CDS 4158989 4159975 . + 0 Mb3806 probable oxidoreductase Mb3806, -, len: 328 aa. Equivalent to Rv3777, len: 328 aa, from Mycobacterium tuberculosis strain H7Rv,(99.7% identity in 328 aa overlap). Probable oxidoreductase (EC 1.-.-.-), equivalent to Q9CD96|ML0118 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (336 aa) FASTA scores: opt: 1661, E(): 1.1e-87, (76.0% identity in 325 aa overlap). Also highly similar to many e.g. Q9XA55|SCGD3.24c PUTATIVE QUINONE OXIDOREDUCTASE (EC 1.6.5.5) from Streptomyces coelicolor (326 aa) FASTA scores: opt: 1118, E(): 1.3e-64, (59.6% identity in 312 aa overlap); O65423|F18E5.200|F17L22.40|AT4G21580 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Arabidopsis thaliana (Mouse-ear cress) (325 aa), FASTA scores: opt: 1110, E(): 3e-56, (52.15% identity in 326 aa overlap); Q98FI0|MLL3767 NADPH QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 980,E(): 7.9e-49, (47.85% identity in 324 aa overlap); etc. Q7TVP4 No intermediary metabolism and respiration Rv3777 NC_002945.3 Mycobrowser_v2 CDS 4338393 4339127 . - 0 Mb3947c CONSERVED HYPOTHETICAL PROTEIN Mb3947c, -, len: 244 aa. Equivalent to Rv3916c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Conserved hypothetical protein, equivalent to Q50200|ML2705|L222-ORF1 HYPOTHETICAL PROTEIN from Mycobacterium leprae (259 aa), FASTA scores: opt: 1266,E(): 2e-74, (76.4% identity in 250 aa overlap). Also highly similar (but with gaps) to Q9R3S2|STH24.10 HYPOTHETICAL 22.6 KDA PROTEIN from Streptomyces coelicolor (205 aa), FASTA scores: opt: 387, E(): 7.5e-18, (40.25% identity in 231 aa overlap). Q7TVC6 No conserved hypotheticals Rv3916c NC_002945.3 Mycobrowser_v2 CDS 4163284 4163820 . + 0 Mb3809 conserved protein Mb3809, -, len: 178 aa. Equivalent to Rv3780, len: 178 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 178 aa overlap). Conserved hypothetical protein, equivalent to Q9CD99|ML0115 HYPOTHETICAL 19.1 KDA PROTEIN from Mycobacterium leprae (174 aa), FASTA scores: opt: 903, E(): 2.3e-48, (82.95% identity in 170 aa overlap). Also highly similar to Q9XA56|SCGD3.23c HYPOTHETICAL 19.5 KDA PROTEIN from Streptomyces coelicolor (179 aa), FASTA scores: opt: 692,E(): 1.8e-35, (65.9% identity in 170 aa overlap). Note that this putative protein is 4 aa longer at the N-terminus compared to previous annotation (in Nature 393: 537-544 (1998)). X2BQ23 No conserved hypotheticals Rv3780 NC_002945.3 Mycobrowser_v2 CDS 4163824 4164645 . + 0 Mb3810 rfbE PROBABLE O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER RFBE Mb3810, rbfE, len: 273 aa. Equivalent to Rv3781,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Probable rfbE,polysaccharide-transport ATP-binding protein ABC transporter (see citation below), involved in O-antigen/lipopolysaccharides (LPS) transport, equivalent to Q9CDA0|ML0114 PUTATIVE ABC TRANSPORTER ATP-BINDING COMPONENT from Mycobacterium leprae (272 aa), FASTA scores: opt: 1581, E(): 3e-83, (91.4% identity in 267 aa overlap). Also highly similar to AAK71283 LPS/O-ANTIGEN EXPORT PERMEASE from Coxiella burnetii (258 aa), FASTA scores: opt: 793, E(): 2.5e-38, (45.45% identity in 253 aa overlap); Q9PAF0|XF2568 ABC TRANSPORTER ATP-BINDING PROTEIN from Xylella fastidiosa (246 aa), FASTA scores: opt: 758, E(): 2.4e-36, (47.75% identity in 243 aa overlap); Q56903|RFBE_YEREN O-ANTIGEN EXPORT SYSTEM ATP-BINDING PROTEIN from Yersinia enterocolitica (239 aa),FASTA scores: opt: 697, E(): 7e-33, (48.65% identity in 224 aa overlap); Q50863|RFBB_MYXXA O-ANTIGEN EXPORT SYSTEM ATP-BINDING from Myxococcus xanthus (437 aa), FASTA scores: opt: 605, E(): 2e-27, (42.05% identity in 207 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7TVP1 No cell wall and cell processes Rv3781 NC_002945.3 Mycobrowser_v2 CDS 4169905 4170831 . - 0 Mb3816c CONSERVED HYPOTHETICAL PROTEIN Mb3816c, -, len: 308 aa. Equivalent to Rv3787c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Conserved hypothetical protein, highly similar to several mycobacterial hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c from Mycobacterium tuberculosis (367 aa), FASTA scores: opt: 1038, E(): 1.6e-58, (55.85% identity in 283 aa overlap); O53795|MBE50c|Rv0731c|MTV041.05c from Mycobacterium tuberculosis (318 aa), FASTA scores: opt: 1030,E()|Rv0731c|MTV041.05c from Mycobacterium tuberculosis (318 aa), FASTA scores: opt: 1030, E(): 4.5e-58, (56.15% identity in 292 aa overlap); Q9CCZ4|ML2640 from Mycobacterium leprae (310 aa) FASTA scores: opt: 709, E(): 9.9e-38, (43.75% identity in 279 aa overlap). X2BPK3,Q7TVN7 No conserved hypotheticals Rv3787c NC_002945.3 Mycobrowser_v2 CDS 4164642 4165556 . + 0 Mb3811 glft1 udp-galactofuranosyl transferase glft1 Mb3811, -, len: 304 aa. Equivalent to Rv3782, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Possible L-rhamnosyltransferase (EC 2.4.1.-), equivalent to Q9CDA1|RFBE|ML0113 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (283 aa), FASTA scores: opt: 1583,E(): 9.3e-96, (81.6% identity in 277 aa overlap). Also some similarity with AAK68916|WCFN PUTATIVE GLYCOSYLTRANSFERASE from Bacteroides fragilis (291 aa) FASTA scores: opt: 241, E(): 2.1e-08, (30.75% identity in 195 aa overlap); O58161|PH0424 HYPOTHETICAL 40.5 KDA PROTEIN from Pyrococcus horikoshii (348 aa), FASTA scores: opt: 194, E(): 2.8e-05, (23.85% identity in 302 aa overlap); O26448|MTH348 RHAMNOSYL TRANSFERASE from Methanothermobacter thermautotrophicus (313 aa) FASTA scores: opt: 177, E(): 0.00033, (28.2% identity in 333 aa overlap); O07868|CPS19BQ PUTATIVE RHAMNOSYL TRANSFERASE FASTA (300 aa) scores: opt: 156, E(): 0.0074, (25.45% identity in 232 aa overlap); and other putative transferases. Note that C-terminal end shows some similarity with part of Q05161|RFB O-ANTIGEN BIOSYNTHESIS PROTEIN B from Escherichia coli strain 0101. Note that previously known as rfbE. Q7TVP0 No cell wall and cell processes Rv3782 NC_002945.3 Mycobrowser_v2 CDS 4215503 4216288 . - 0 Mb3844c possible acyltransferase Mb3844c, -, len: 261 aa. Equivalent to Rv3814c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Possible acyltransferase (EC 2.3.1.-), highly similar to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa), FASTA scores: opt: 753, E(): 7.7e-42,(46.75% identity in 246 aa overlap). Also highly similar to many acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 587, E(): 4.6e-31,(41.95% identity in 243 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 293, E(): 6.6e-12, (29.2% identity in 267 aa overlap); Q9PNZ5|AAS|CJ0938 PUTATIVE 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE / ACYL-ACYL CARRIER PROTEIN SYNTHETASE from Campylobacter jejuni (1170 aa), FASTA scores: opt: 274, E(): 3.9e-10,(29.1% identity in 219 aa overlap) (similarity only with middle section); Q9EY25 PUTATIVE ACETYL TRANSFERASE from Xanthomonas oryzae pv. oryzae (249 aa), FASTA scores: opt: 238, E(): 2.4e-08, (29.2% identity in 209 aa overlap); etc. Also highly similar to downstream ORFs O07808|Rv3815c|MTCY409.15 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (251 aa), FASTA scores: opt: 1069, E(): 2.1e-62, (60.4% identity in 245 aa overlap); and O07807|Rv3816c|MTCY409.14 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (259 aa), FASTA scores: opt: 776, E(): 2.5e-43, (50.9% identity in 228 aa overlap). And similar to O53516|Rv2182c|MTV021.15c HYPOTHETICAL 27.0 KDA PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 239, E(): 2e-08,(30.6% identity in 232 aa overlap). Q7TVL9 No intermediary metabolism and respiration Rv3814c NC_002945.3 Mycobrowser_v2 CDS 4165553 4166395 . + 0 Mb3812 rfbD PROBABLE O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER RFBD Mb3812, rfbD, len: 280 aa. Equivalent to Rv3783,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Possible rfbD,polysaccharide-transport integral membrane protein ABC transporter (see citation below), involved in O-antigen/lipopolysaccharides (LPS) transport, equivalent to Q9CDA2|ML0112 PUTATIVE ABC TRANSPORTER COMPONENT from Mycobacterium leprae (276 aa), FASTA scores: opt: 1646,E(): 4e-102, (84.3% identity in 280 aa overlap). Also highly similar to Q9PAF1|XF2567 ABC TRANSPORTER PERMEASE PROTEIN from Xylella fastidiosa (267 aa), FASTA scores: opt: 723, E(): 7.6e-41, (41.3% identity in 259 aa overlap); and similar to others e.g. Q56902|RFBD_YEREN O-ANTIGEN EXPORT SYSTEM PERMEASE PROTEIN from Yersinia enterocolitica (259 aa), FASTA scores: opt: 566, E(): 2e-30, (28.05% identity in 264 aa overlap); Q06955|RFBH RFBH PROTEIN (involved in the export of lipopolysaccharide) (alias Q9KVA3|VC0246) LIPOPOLYSACCHARIDE/O-ANTIGEN TRANSPORT PROTEIN from Vibrio cholerae (257 aa), FASTA scores: opt: 358, E(): 1.3e-16,(24.4% identity in 258 aa overlap); Q9HTB8|WZM|PA5451 MEMBRANE SUBUNIT OF A-BAND LPS EFFLUX TRANSPORTER from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 263,E(): 2.7e-10, (25.45% identity in 263 aa overlap); etc. BELONGS TO THE ABC-2 SUBFAMILY OF INTEGRAL MEMBRANE PROTEINS. Q7TVN9 No cell wall and cell processes Rv3783 NC_002945.3 Mycobrowser_v2 CDS 4166551 4167531 . + 0 Mb3813 rfbB possible dtdp-glucose 4,6-dehydratase Mb3813, rfbB, len: 326 aa. Equivalent to Rv3784,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 326 aa overlap). Possible rfbB,dTDP-glucose 4,6-dehydratase (EC 4.2.1.46), similar to others e.g. Q9YCT1|APE1180 LONG HYPOTHETICAL DTDP-GLUCOSE 4,6-DEHYDRATASE from Aeropyrum pernix (330 aa) FASTA scores: opt: 598, E(): 3.7e-30, (34.9% identity in 315 aa overlap); O27817|MTH1789 DTDP-GLUCOSE 4,6-DEHYDRATASE from Methanothermobacter thermautotrophicus (336 aa) FASTA scores: opt: 587, E(): 1.8e-29, (34.9% identity in 315 aa overlap); Q9X5W0|GRSE TDP-GLUCOSE-4,6-DEHYDRATASE HOMOLOG from Streptomyces griseus (324 aa), FASTA scores: opt: 583, E(): 3.2e-29, (35.7% identity in 325 aa overlap); Q9K7J7|SPSJ|BH3364 SPORE COAT POLYSACCHARIDE SYNTHESIS (DTDP GLUCOSE 4, 6-DEHYDRATASE) from Bacillus halodurans (321 aa), FASTA scores: opt: 562, E(): 6.5e-28, (33.0% identity in 318 aa overlap); Q9UZH2|RFBB|PAB0785 DTDP-GLUCOSE 4,6-DEHYDRATASE from Pyrococcus abyssi (333 aa), FASTA scores: opt: 552, E(): 2.8e-27, (33.95% identity in 318 aa overlap); P27830|RFFG_ECOLI|B3788 DTDP-GLUCOSE 4,6-DEHYDRATASE from Escherichia coli strain K12 (355 aa), FASTA scores: opt: 401, E(): 7.5e-28, (31.3% identity in 348 aa overlap); etc. But also similar to several UDP-glucose 4-epimerases (EC 5.1.3.2) and other proteins e.g. O59375|PH1742 LONG HYPOTHETICAL UDP-GLUCOSE 4-EPIMERASE from Pyrococcus horikoshii (306 aa) FASTA scores: opt: 600, E(): 2.6e-30, (34.5% identity in 313 aa overlap); Q9ZGC7|LANH14 NDP-HEXOSE 4,6-DEHYDRATASE HOMOLOGfrom Streptomyces cyanogenus (326 aa), FASTA scores: opt: 593, E(): 7.6e-30, (36.45% identity in 321 aa overlap); Q57664|GALE_METJA|MJ0211 PUTATIVE UDP-GLUCOSE 4-EPIMERASE from Methanococcus jannaschii (305 aa) FASTA scores: opt: 575, E(): 9.6e-29, (32.6% identity in 313 aa overlap); etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY, DTDP-GLUCOSE DEHYDRATASE SUBFAMILY. Note that previously known as epiB. Q7TVN8 No intermediary metabolism and respiration Rv3784 NC_002945.3 Mycobrowser_v2 CDS 4167615 4168688 . + 0 Mb3814 HYPOTHETICAL PROTEIN Mb3814, -, len: 357 aa. Equivalent to Rv3785, len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). Hypothetical unknown protein. Note that this putative protein is equivalent to AAK48258|MT3893 NAD-DEPENDENT EPIMERASE/DEHYDRATASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (712 aa), but shorter 355 aa. X2BQ24 No conserved hypotheticals Rv3785 NC_002945.3 Mycobrowser_v2 CDS 4168669 4169892 . - 0 Mb3815c unknown protein Mb3815c, -, len: 407 aa. Equivalent to Rv3786c,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Hypothetical unknown protein. Segment between aa 265-300 (approximatively) is highly similar to part of O03937|RORF1608 MINOR CAPSID PROTEIN from Bacteriophage phig1e (1608 aa), FASTA scores: opt: 242, E(): 8.4e-07, (26.85% identity in 272 aa overlap); Q9ETT9|ORF36 PUTATIVE PEPTIDASE from Corynebacterium equii (Rhodococcus equi) plasmid pREAT701 (p33701) and Plasmid virulence (546 aa), FASTA scores: opt: 231, E(): 1.6e-06, (34.15% identity in 167 aa overlap); O69910|SC2E1.40c HYPOTHETICAL 22.8 KDA PROTEIN. from Streptomyces coelicolor (226 aa) FASTA scores: opt: 218, E(): 4.6e-06, (34.15% identity in 164 aa overlap); and others. X2BP78 No conserved hypotheticals Rv3786c NC_002945.3 Mycobrowser_v2 CDS 4171075 4171560 . + 0 Mb3817 HYPOTHETICAL PROTEIN Mb3817, -, len: 161 aa. Equivalent to Rv3788, len: 161 aa, from Mycobacetrium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Hypothetical unknown protein. X2BPE5,P65096 No conserved hypotheticals Rv3788 NC_002945.3 Mycobrowser_v2 CDS 4247283 4247981 . - 0 Mb3867c PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) (PHOSPHOGLYCERATE PHOSPHOMUTASE) Mb3867c, -, len: 232 aa. Equivalent to Rv3837c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 232 aa overlap). Probable phosphoglycerate mutase (EC 5.4.2.-), equivalent to Q9CDC3|ML0079 PUTATIVE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (231 aa), FASTA scores: opt: 1116,E(): 7.3e-66, (71.55% identity in 232 aa overlap). Also similar to others e.g. Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 474, E(): 6.4e-24, (41.85% identity in 203 aa overlap); Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa) FASTA scores: opt: 349, E(): 1e-15, (33.2% identity in 223 aa overlap); Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 256, E(): 1.2e-09, (34.0% identity in 203 aa overlap); Q9RVD2|DR1097 PUTATIVE PHOSPHOGLYCERATE MUTASE from Deinococcus radiodurans (232 aa), FASTA scores: opt: 201, E(): 5.1e-06, (31.45% identity in 175 aa overlap); etc. Also similar to P71724|Rv2419c|MTCY428.28|MTCY253.01 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium tuberculosis (223 aa), FASTA scores: opt: 210, E(): 1.3e-06, (32.0% identity in 172 aa overlap). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. Q7TVJ7 No intermediary metabolism and respiration Rv3837c NC_002945.3 Mycobrowser_v2 CDS 4173460 4174224 . + 0 Mb3820 dpre2 decaprenylphosphoryl-d-2-keto erythro pentose reductase Mb3820, -, len: 254 aa. Equivalent to Rv3791, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to Q9CDA5|ML0108 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (254 aa), FASTA scores: opt: 1458, E(): 1.6e-83,(89.0% identity in 254 aa overlap); and O05764 PUTATIVE PROTEIN BELONGING TO THE SHORT-CHAIN ALCOHOL DEHYDROGENASE from Mycobacterium smegmatis (254 aa), FASTA scores: opt: 1412, E(): 1.2e-80, (85.05% identity in 254 aa overlap). Also highly similar to Q9KZA5|SC5G8.09c PUTATIVE SHORT-CHAIN DEHYDROGENASE from Streptomyces coelicolor (256 aa), FASTA scores: opt: 733, E(): 1.8e-38, (45.3% identity in 254 aa overlap); and P43168|YMP3_STRCO HYPOTHETICAL OXIDOREDUCTASE from Streptomyces coelicolor (251 aa), FASTA scores: opt: 623, E(): 1.2e-31, (42.15% identity in 254 aa overlap); and similar to various oxidoreductases (principally acetoacetyl-CoA reductases) e.g. P14697|PHBB_ALCEU ACETOACETYL-COA REDUCTASE (EC 1.1.1.36) (246 aa) from Alcaligenes eutrophus (Ralstonia eutropha) (246 aa) FASTA scores: opt: 264, E(): 2.3e-09,(29.9% identity in 204 aa overlap); P45375|PHBB_CHRVI ACETOACETYL-COA REDUCTASE from Chromatium vinosum (246 aa), FASTA scores: opt: 261, E(): 3.5e-09, (27.45% identity in 226 aa overlap); Q9RT30|DR1938 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Deinococcus radiodurans (283 aa), FASTA scores: opt: 251,E(): 1.7e-08, (27.55% identity in 236 aa overlap); etc. Also similar to Q10681|YK73_MYCTU|Rv2073c|MT2133|MTCY49.12 PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mycobacterium tuberculosis (249 aa), FASTA scores: opt: 589, E(): 1.5e-29, (41.25% identity in 252 aa overlap). Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. X2BP85,P66784 No lipid metabolism Rv3791 NC_002945.3 Mycobrowser_v2 CDS 4245320 4246669 . + 0 Mb3865 conserved membrane protein Mb3865, -, len: 449 aa. Equivalent to Rv3835, len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable conserved membrane protein, equivalent to Q9CDC2|ML0081 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (450 aa), FASTA scores: opt: 2079, E(): 1.8e-74, (69.35% identity in 457 aa overlap). Q7TVJ9 No cell wall and cell processes Rv3835 NC_002945.3 Mycobrowser_v2 CDS 4187380 4189161 . + 0 Mb3826 fadE35 PROBABLE ACYL-COA DEHYDROGENASE FADE35 Mb3826, fadE35, len: 593 aa. Equivalent to Rv3797,len: 593 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 593 aa overlap). Probable fadE35,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9HY33|PA3593 from Pseudomonas aeruginosa (575 aa) FASTA scores: opt: 838, E(): 2.1e-46, (35.3% identity in 569 aa overlap); Q9ANZ8|AIDB from Burkholderia pseudomallei (Pseudomonas pseudomallei) (554 aa), FASTA scores: opt: 633, E(): 3.4e-33, (33.1% identity in 480 aa overlap); Q9HX44|PA3972 from Pseudomonas aeruginosa (549 aa) FASTA scores: opt: 560, E(): 1.7e-28, (29.9% identity in 569 aa overlap); P33224|AIDB_ECOLI|B4187 from Escherichia coli strain K12 (541 aa), FASTA scores: opt: 455, E(): 1e-21,(31.15% identity in 514 aa overlap); etc. Also similar to O86368|FADE8|Rv0672|MTCI376.02c ACYL-COA DEHYDROGENASE from Mycobacterium tuberculosis (542 aa), FASTA scores: opt: 479, E(): 2.9e-23, (32.2% identity in 460 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7TVN1 No NC_002945.3 Mycobrowser_v2 CDS 4174227 4176158 . + 0 Mb3821 afta arabinofuranosyltransferase afta Mb3821, -, len: 643 aa. Equivalent to Rv3792, len: 643 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 643 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 21 aa, to Q9CDA6|ML0107 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (632 aa), FASTA scores: opt: 1981, E(): 2.1e-110,(77.5% identity in 631 aa overlap). C-terminal end highly similar to C-terminus of O05765 PUTATIVE PRODUCT ORF 3 from Mycobacterium smegmatis (603 aa), FASTA scores: opt: 1261, E(): 1.4e-67, (70.7% identity in 266 aa overlap). X2BPK7,Q7TVN5 No cell wall and cell processes Rv3792 NC_002945.3 Mycobrowser_v2 CDS 4176158 4179442 . + 0 Mb3822 embC INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBC (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE) Mb3822, embC, len: 1094 aa. Equivalent to Rv3793,len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1094 aa overlap). embC, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below),equivalent to Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa) FASTA scores: opt: 6078,E(): 0, (82.95% identity in 1072 aa overlap); Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 5523, E(): 0, (75.35% identity in 1072 aa overlap). Also similar to Q9CDA9|EMBB| ML0104 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1083 aa), FASTA scores: opt: 2789, E(): 1.9e-156, (44.0% identity in 1095 aa overlap); O30406|EMBB PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1082 aa), FASTA scores: opt: 2746, E(): 6.4e-154, (44.6% identity in 1096 aa overlap); etc. Also similar to to P72030|EMBB|Rv3795|MTCY13D12.29 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1098 aa), FASTA scores: opt: 2276, E(): 3.1e-126, (44.45% identity in 1118 aa overlap); and P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1974, E(): 1.9e-108, (41.0% identity in 1110 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature; and PS00017 ATP/GTP-binding site motif A (P-loop). X2BPF1,Q7TVN4 No NC_002945.3 Mycobrowser_v2 CDS 4179528 4182812 . + 0 Mb3823 embA INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBA (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE) Mb3823, embA, len: 1094 aa. Equivalent to Rv3794,len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1094 aa overlap). embA, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below),equivalent to P71485|EMBA ARABINOSYL TRANSFERASE from Mycobacterium avium (1108 aa), FASTA scores: opt: 5024,E(): 0, (81.9% identity in 1109 aa overlap); Q9CDA8|EMBA|ML0105 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1111 aa), FASTA scores: opt: 4782,E(): 0, (78.6% identity in 1111 aa overlap); Q50394|EMBA PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1092 aa), FASTA scores: opt: 4100, E(): 0,(67.4% identity in 1092 aa overlap). Also similar to Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa), FASTA scores: opt: 1933,E(): 1.5e-100, (40.6% identity in 1108 aa overlap); Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 1870, E(): 5.1e-97, (41.4% identity in 1113 aa overlap); etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1974, E(): 7.7e-103, (40.9% identity in 1110 aa overlap); and P72030|EMBB|Rv3795|MTCY13D12.29 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1098 aa), FASTA scores: opt: 1288, E(): 2.1e-64, (42.5% identity in 1114 aa overlap). Supposed regulated by embR|Rv1267c. X2BPU8,P0A561 No NC_002945.3 Mycobrowser_v2 CDS 4189288 4189905 . + 0 Mb3827 PUTATIVE TRANSPOSASE [FIRST PART] Mb3827, -, len: 205 aa. Equivalent to 5' end of Rv3798, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 195 aa overlap). Putative transposase for insertion sequence element IS1557, highly similar to Q60255 SIMILAR TO TRANSPOSASE OF ISAE1 FROM ALCALIGENES EUTROPHUS H1-4 (FRAGMENT) from dibenzofuran-degrading bacterium DPO360 (163 aa) FASTA scores: opt: 767, E(): 3.2e-42, (67.25% identity in 168 aa overlap); and similar to P74920 TRANSPOSASE from Thiobacillus ferrooxidans (404 aa), FASTA scores: opt: 375, E(): 1.1e-16, (27.55% identity in 439 aa overlap); Q48349 TRANSPOSASE from Alcaligenes eutrophus (Ralstonia eutropha) (408 aa), FASTA scores: opt: 324, E(): 2e-13,(3.9% identity in 369 aa overlap); Q9FDC1|TNP TRANSPOSASE from Burkholderia mallei (Pseudomonas mallei) (386 aa) FASTA scores: opt: 282, E(): 9.8e-11, (25.85% identity in 391 aa overlap); etc. C-terminal end identical to O53804|Rv0741|MTV041.15 TRANSPOSASE from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 582, E(): 1.8e-30, (85.6% identity in 104 aa overlap). BELONGS TO THE TRANSPOSASE FAMILY 12. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3798 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828. Q7TTK1 No NC_002945.3 Mycobrowser_v2 CDS 4189880 4190611 . + 0 Mb3828 PUTATIVE TRANSPOSASE [SECOND PART] Mb3828, -, len: 243 aa. Equivalent to 3' end of Rv3798, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 243 aa overlap). Putative transposase for insertion sequence element IS1557, highly similar to Q60255 SIMILAR TO TRANSPOSASE OF ISAE1 FROM ALCALIGENES EUTROPHUS H1-4 (FRAGMENT) from dibenzofuran-degrading bacterium DPO360 (163 aa) FASTA scores: opt: 767, E(): 3.2e-42, (67.25% identity in 168 aa overlap); and similar to P74920 TRANSPOSASE from Thiobacillus ferrooxidans (404 aa), FASTA scores: opt: 375, E(): 1.1e-16, (27.55% identity in 439 aa overlap); Q48349 TRANSPOSASE from Alcaligenes eutrophus (Ralstonia eutropha) (408 aa), FASTA scores: opt: 324, E(): 2e-13,(3.9% identity in 369 aa overlap); Q9FDC1|TNP TRANSPOSASE from Burkholderia mallei (Pseudomonas mallei) (386 aa) FASTA scores: opt: 282, E(): 9.8e-11, (25.85% identity in 391 aa overlap); etc. C-terminal end identical to O53804|Rv0741|MTV041.15 TRANSPOSASE from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 582, E(): 1.8e-30, (85.6% identity in 104 aa overlap). BELONGS TO THE TRANSPOSASE FAMILY 12. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3798 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828. Q7TTF3 No NC_002945.3 Mycobrowser_v2 CDS 4216306 4217061 . - 0 Mb3845c possible acyltransferase Mb3845c, -, len: 251 aa. Equivalent to Rv3815c,len: 251 a, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Possible acyltransferase (EC 2.3.1.-), highly similar to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa), FASTA scores: opt: 845, E(): 2.7e-47,(53.25% identity in 246 aa overlap). Also highly similar to Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 656,E(): 3.7e-35, (47.85% identity in 234 aa overlap); and similar to many putative acyltransferases and hypothetical proteins e.g. P74498|SLL1848 HYPOTHETICAL 24.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (225 aa) FASTA scores: opt: 275, E(): 1.2e-10, (34.8% identity in 181 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 266,E(): 5.2e-10, (29.7% identity in 229 aa overlap); Q9PNZ5|AAS|CJ0938 PUTATIVE 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE/ ACYL-ACYL CARRIER PROTEIN SYNTHETASE from Campylobacter jejuni (1170 aa), FASTA scores: opt: 264, E(): 2.3e-09,(23.55% identity in 221 aa overlap) (similarity only with middle section); etc. Also highly similar to upstream ORF O07809|Rv3814c|MTCY409.16 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 1069, E(): 1e-61, (60.4% identity in 245 aa overlap) ; and downstream ORF O07807|Rv3816c|MTCY409.14 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (259 aa) FASTA scores: opt: 847, E(): 2e-47, (55.7% identity in 246 aa overlap). And similar to O53516|Rv2182c|MTV021.15c HYPOTHETICAL 27.0 KDA PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 237, E(): 3.6e-08, (30.9% identity in 233 aa overlap). Q7TVL8 No intermediary metabolism and respiration Rv3815c NC_002945.3 Mycobrowser_v2 CDS 4190653 4192221 . - 0 Mb3829c accD4 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 4 ACCD4 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) Mb3829c, accD4, len: 522 aa. Equivalent to Rv3799c,len: 522 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 522 aa overlap). Probable accD4,propyonyl-CoA carboxylase beta chain 4 (EC 6.4.1.3),equivalent to Q9CDB0|ACCD4|ML0102 PUTATIVE ACYL COA CARBOXYLASE from Mycobacterium leprae (517 aa) FASTA scores: opt: 3154, E(): 8e-187, (91.2% identity in 511 aa overlap) . Also similar to many e.g. Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA scores: opt: 1714,E(): 4.4e-98, (50.0% identity in 510 aa overlap); P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa), FASTA scores: opt: 1549, E(): 6.6e-88, (50.65% identity in 519 aa overlap); Q9WZH5|TM0716 from Thermotoga maritima (515 aa) FASTA scores: opt: 1529, E(): 1.1e-86, (46.7% identity in 512 aa overlap); etc. Also similar to P53002|PCCB_MYCLE|ACCD5|PCCB|ML0731|B1308_C1_125 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 from Mycobacterium leprae (549 aa), FASTA scores: opt: 1493, E(): 1.9e-84,(49.8% identity in 514 aa overlap); and P96885|PCC5_MYCTU|ACCD5|PCCB|Rv3280|MT3379.1|MTCY71.20 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 from Mycobacterium tuberculosis (548 aa), FASTA scores: opt: 1471, E(): 4.2e-83, (49.15% identity in 515 aa overlap). BELONGS TO THE ACCD/PCCB FAMILY. Q7TVN0 No NC_002945.3 Mycobrowser_v2 CDS 4192218 4197419 . - 0 Mb3830c pks13 POLYKETIDE SYNTHASE PKS13 Mb3830c, pks13, len: 1733 aa. Equivalent to Rv3800c, len: 1733 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1733 aa overlap). Probable pks13, polyketide synthase (EC undetermined),equivalent to Q9CDB1|PKS13|ML0101 POLYKETIDE SYNTHASE from Mycobacterium leprae (1784 aa), FASTA scores: opt: 7454,E(): 0, (83.6% identity in 1748 aa overlap); and similar to Q9Z5K6|ML2357|MLCB12.02c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1871 aa), FASTA scores: opt: 1682, E(): 1.2e-85, (38.3% identity in 1096 aa overlap). Also similar in part to many e.g. Q9ADL6|SORA SORAPHEN POLYKETIDE SYNTHASE A from Polyangium cellulosum (6315 aa) FASTA scores: opt: 1422, E(): 1e-70, (31.45% identity in 1616 aa overlap); AAK73501|AMPHI AMPHI PROTEIN (involved in amphotericin biosynthesis) from Streptomyces nodosus (9510 aa), FASTA scores: opt: 1441, E(): 1.2e-71, (30.45% identity in 1662 aa overlap); Q9RFL0|MTAB MTAB PROTEIN (involved in myxothiazol biosynthesis) from Stigmatella aurantiaca (4003 aa), FASTA scores: opt: 1429, E(): 2.8e-71, (33.8% identity in 1089 aa overlap); Q9L4X2|NYSJ from Streptomyces noursei (5435 aa), FASTA scores: opt: 1407, E(): 6.1e-70, (30.5% identity in 1764 aa overlap); CAC37876|SC1G7.01c from Streptomyces coelicolor (3489 aa) FASTA scores: opt: 1382, E(): 1e-68, (31.05% identity in 1489 aa overlap); etc. Also highly similar to Q10977|PPSA_MYCTU|Rv2931|MT3000|MTCY338.20 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE from Mycobacterium tuberculosis (1876 aa), FASTA scores: opt: 1728, E(): 3.4e-88, (36.95% identity in 1269 aa overlap); and P96203|PPSD|Rv2934|MTCY19H9.02. Contains PS00606 Beta-ketoacyl synthases active site. Q7TVM9 No lipid metabolism Rv3800c NC_002945.3 Mycobrowser_v2 CDS 4205198 4206106 . - 0 Mb3836c ubia decaprenylphosphoryl-5-phosphoribose (dppr) synthase (decaprenyl-phosphate 5-phosphoribosyltransferase) Mb3836c, -, len: 302 aa. Equivalent to Rv3806c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Possible conserved integral membrane protein, equivalent to Q9CDB5|ML0095 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (302 aa), FASTA scores: opt: 1677, E(): 3.9e-103,(83.75% identity in 302 aa overlap). Also highly similar to others e.g. Q9KZA2|SC5G8.12 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 937, E(): 2e-54, (51.4% identity in 292 aa overlap); AAK79783|CAC1818 CONSERVED MEMBRANE PROTEIN,POSSIBLE 4-HYDROXYBENZOATE from Clostridium acetobutylicum (290 aa), FASTA scores: opt: 467, E(): 1.5e-23, (26.9% identity in 290 aa overlap); Q98KY3|MLL1266 NODULATION PROTEIN NOEC (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Rhizobium loti (Mesorhizobium loti) (297 aa), FASTA scores: opt: 331, E(): 1.4e-14, (27.4% identity in 299 aa overlap); etc. And highly similar to C-terminal part of Q981F8|MLR9393 NODULATION PROTEIN NOEC (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Rhizobium loti (Mesorhizobium loti) plasmid pMLa (541 aa), FASTA scores: opt: 388, E(): 4e-18,(30.9% identity in 301 aa overlap); and P55585|Y4NM_RHISN INTEGRAL MEMBRANE PROTEIN (POSSIBLE PERMEASE/TRANSPORTER) from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (516 aa), FASTA scores: opt: 380, E(): 1.3e-17, (31.85% identity in 295 aa overlap). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. Q7TVM6 No cell wall and cell processes Rv3806c NC_002945.3 Mycobrowser_v2 CDS 4197426 4199339 . - 0 Mb3831c fadD32 fatty-acid-amp ligase fadd32 (fatty-acid-amp synthetase) (fatty-acid-amp synthase). also shown to have acyl-acp ligase activity. Mb3831c, fadD32, len: 637 aa. Equivalent to Rv3801c, len: 637 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 637 aa overlap). Probable fadD32, fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to Q9CDB2|FADD32|ML0100 PUTATIVE ACYL-COA SYNTHETASE from Mycobacterium leprae (635 aa), FASTA scores: opt: 3892,E(): 0, (93.05% identity in 632 aa overlap); and highly similar to others from Mycobacterium leprae. Also similar to others from Mycobacterium tuberculosis e.g. P95288|FADD31|Rv1925|MTCY09F9.39c (620 aa), FASTA scores: opt: 1567, E(): 1.7e-88, (47.05% identity in 612 aa overlap); MTCY338_18, MTCY349_40, MTV005_21, MTCY24G1_8,MTCY19G5_7, MTCY4D9_17; and MBU75685_1 ACYL-COA LIGASE from Mycobacterium bovis. X2BPL9,Q7TTR2 No lipid metabolism Rv3801c NC_002945.3 Mycobrowser_v2 CDS 4199628 4200638 . - 0 Mb3832c probable conserved membrane protein Mb3832c, -, len: 336 aa. Equivalent to Rv3802c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Conserved hypothetical protein, equivalent to Q9CDB3|ML0099 HYPOTHETICAL PROTEIN from Mycobacterium leprae (336 aa) FASTA scores: opt: 1759, E(): 1.1e-85, (75.5% identity in 335 aa overlap). Contains probable N-terminal signal sequence followed by Pro-rich region. Q7TVM8 No cell wall and cell processes Rv3802c NC_002945.3 Mycobrowser_v2 CDS 4201915 4202931 . - 0 Mb3834c fbpA SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) (ANTIGEN 85 COMPLEX A) Mb3834c, fbpA, len: 338 aa. Equivalent to Rv3804c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 338 aa overlap). fbpA (alternate gene names: mpt44, 85A), precursor of the 85-A antigen (fibronectin-binding protein A) (mycolyl transferase 85A) (EC 2.3.1.-) (see citations below), identical to P17944|P17996|FBPA|MPT44 ANTIGEN 85-A PRECURSOR from Mycobacterium bovis (338 aa), FASTA scores: opt: 2341,E(): 1.2e-132, (100.0% identity in 338 aa overlap); and highly similar to other Mycobacterial antigen precursors e.g. O52956|A85A_MYCAV|FBPA ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium avium (347 aa), FASTA scores: opt: 1987, E(): 1.7e-111, (82.55% identity in 338 aa overlap); Q05861|A85A_MYCLE|FBPA|ML0097 ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium leprae (330 aa), FASTA scores: opt: 1936, E(): 1.9e-108, (83.0% identity in 329 aa overlap); O06052|A85A_MYCGO|FBPA ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium gordonae (339 aa), FASTA scores: opt: 1932,E(): 3.3e-108, (80.45% identity in 338 aa overlap); etc. Also highly similar to P31952|A85B_MYCTU|FBPB|Rv1886c|MT1934|MTCY180.32 SECRETED ANTIGEN 85-B from Mycobacterium tuberculosis (325 aa),FASTA scores: opt: 1830, E(): 3.9e-102, (78.85% identity in 317 aa overlap); P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 SECRETED ANTIGEN 85-C from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 1597, E(): 3.4e-88, (67.25% identity in 336 aa overlap). X2BQ28,P0C2T1 No NC_002945.3 Mycobrowser_v2 CDS 4203226 4205109 . - 0 Mb3835c aftb possible arabinofuranosyltransferase aftb Mb3835c, -, len: 627 aa. Equivalent to Rv3805c,len: 627 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 627 aa overlap). Probable conserved transmembrane protein, equivalent, but shorter 19 aa, to Q9CDB4|ML0096 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (649 aa), FASTA scores: opt: 3511, E(): 1.1e-204,(80.9% identity in 629 aa overlap). Equivalent to AAK48278 from Mycobacterium tuberculosis strain CDC1551 (641 aa) but shorter 14 aa. Q7TVM7 No cell wall and cell processes Rv3805c NC_002945.3 Mycobrowser_v2 CDS 4206113 4206610 . - 0 Mb3837c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb3837c, -, len: 165 aa. Equivalent to Rv3807c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Possible conserved transmembrane protein, equivalent to Q9CDB6|ML0094 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (192 aa), FASTA scores: opt: 714, E(): 2.4e-38, (72.85% identity in 151 aa overlap). Also highly similar to Q9KZA3|SC5G8.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 324,E(): 1.1e-13, (41.5% identity in 159 aa overlap); and similar in part to others e.g. Q9K3L3|SCG20A.27 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (230 aa), FASTA scores: opt: 277, E(): 1.3e-10, (41.65% identity in 168 aa overlap); P72269|ORF8 HYPOTHETICAL PROTEIN from Rhodococcus erythropolis (487 aa) FASTA scores: opt: 229, E(): 2.7e-07, (36.25% identity in 149 aa overlap); O86625|SC3A7.24c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (201 aa) FASTA scores: opt: 200, E(): 9.1e-06, (34.95% identity in 146 aa overlap); Q9KYD7|SCD72A.19 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (238 aa) FASTA scores: opt: 178, E(): 0.00026, (35.7% identity in 112 aa overlap); etc. Q7TVM5 No cell wall and cell processes Rv3807c NC_002945.3 Mycobrowser_v2 CDS 4206639 4208552 . - 0 Mb3838c glft2 bifunctional udp-galactofuranosyl transferase glft2 Mb3838c, -, len: 637 aa. Equivalent to Rv3808c,len: 637 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 637 aa overlap). Galactofuranosyl transferase (EC 2.-.-.-) (see citations below), equivalent to Q9CDB7|ML0093 HYPOTHETICAL PROTEIN from Mycobacterium leprae (643 aa) FASTA scores: opt: 3751, E(): 0, (85.4% identity in 643 aa overlap). Contains a beta-glycosyltransferase domain A. Q7TVM4 No cell wall and cell processes Rv3808c NC_002945.3 Mycobrowser_v2 CDS 4208549 4209748 . - 0 Mb3839c glf UDP-GALACTOPYRANOSE MUTASE GLF (UDP-GALP MUTASE) (NAD+-FLAVIN ADENINE DINUCLEOTIDE-REQUIRING ENZYME) Mb3839c, glf, len: 399 aa. Equivalent to Rv3809c,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 399 aa overlap). glf (alternate gene name: ceoA), UDP-galactopyranose mutase (EC 5.4.99.9) (see citations below), identical to previously sequenced gene,and equivalent to Q9CDB8|GLF|ML0092 PUTATIVE UDP-GALACTOPYRANOSE MUTASE from Mycobacterium leprae (413 aa), FASTA scores: opt: 2347, E(): 1.3e-140, (86.6% identity in 396 aa overlap). Also highly similar to others e.g. AAK61905|EPSJ UDP-GALACTOPYRANOSE MUTASE (PROTEIN INVOLVED IN EXOPOLYSACCHARIDES BIOSYNTHESIS) from Streptococcus thermophilus (365 aa), FASTA scores: opt: 972, E(): 5.9e-54, (45.85% identity in 375 aa overlap); P37747|GLF_ECOLI|B2036 UDP-GALACTOPYRANOSE MUTASE from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 958, E(): 4.5e-53, (43.55% identity in 379 aa overlap); O86897|CAP33FN from Streptococcus pneumoniae (369 aa) FASTA scores: opt: 954, E(): 8.1e-53, (44.8% identity in 375 aa overlap); etc. COFACTOR: FAD (BY SIMILARITY). N-TERMINAL SHOWS SIMILARITY TO FAD OR NAD CONTAINING PROTEINS. Q7TVM3 No NC_002945.3 Mycobrowser_v2 CDS 4210012 4210866 . + 0 Mb3840 pirG EXPORTED REPETITIVE PROTEIN PRECURSOR PIRG (CELL SURFACE PROTEIN) (EXP53) Mb3840, pirG, len: 284 aa. Equivalent to Rv3810,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). pirG (alternate gene names: P36 or erp for Exported Repeated Protein), cell surface protein precursor (see citations below),equivalent to P19361|28KD_MYCLE|ML0091 28 KDA ANTIGEN PRECURSOR from Mycobacterium leprae (236 aa), FASTA scores: opt: 555, E(): 9.8e-18, (52.65% identity in 281 aa overlap). X2BPB4,P0A5P5 No cell wall and cell processes Rv3810 NC_002945.3 Mycobrowser_v2 CDS 4211071 4212690 . + 0 Mb3841 CONSERVED HYPOTHETICAL PROTEIN Mb3841, -, len: 539 aa. Equivalent to Rv3811, len: 539 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 539 aa overlap). Conserved hypothetical protein, showing some similarity to Q9KZK5|SCE34.21c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 603,E(): 8.1e-26, (34.4% identity in 404 aa overlap); Q9S2P9|SC5F7.14c HYPOTHETICAL 31.9 KDA PROTEIN from Streptomyces coelicolor (308 aa), FASTA scores: opt: 472,E(): 9.5e-19, (37.5% identity in 208 aa overlap). Middle section (approximatively aa 185-350/390) shows some similarity with Q9GK12 PEPTIDOGLYCAN RECOGNITION PROTEIN PRECURSOR from Camelus dromedarius (Dromedary) (Arabian camel) (193 aa) FASTA scores: opt: 274, E(): 4.6e-08,(32.2% identity in 177 aa overlap); O75594|PGLYRP|PGRP from Homo sapiens (Human) (196 aa), FASTA scores: opt: 272, E(): 6e-08, (30.9% identity in 220 aa overlap); Q9JLN4|PGRP PEPTIDOGLYCAN RECOGNITION PROTEIN from Rattus norvegicus (Rat) (182 aa), FASTA scores: opt: 253, E(): 6.2e-07, (32.15% identity in 171 aa overlap); etc. C-terminal end shows similarity with Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (ONE OF THE TWO MAJOR SECRETED PROTEINS) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa), FASTA scores: opt: 250, E(): 2.7e-06, (39.45% identity in 109 aa overlap). Contains PS00687 Aldehydedehydrogenases glutamic acid active site. Note that previously known as csp. Q7TVM2 No conserved hypotheticals Rv3811 NC_002945.3 Mycobrowser_v2 CDS 4214667 4215488 . - 0 Mb3843c conserved protein Mb3843c, -, len: 273 aa. Equivalent to Rv3813c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 273 aa overlap). Conserved hypothetical protein, equivalent to Q9CDB9|ML0089 HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa) FASTA scores: opt: 1479, E(): 9.6e-81, (80.45% identity in 271 aa overlap); and similar to Q98LI0|MLL1014 from (280 aa) . Also similar to many hypothetical proteins from several organisms e.g. Q9ZBX2|SCD78.27c from Streptomyces coelicolor (280 aa),FASTA scores: opt: 597, E(): 2.2e-28, (43.25% identity in 266 aa overlap); Q9RXR7|DR0240 from Deinococcus radiodurans (284 aa), FASTA scores: opt: 543, E(): 3.5e-25, (38.65% identity in 264 aa overlap); Q99YH5|SPY1700 from Streptococcus pyogenes (274 aa) FASTA scores: opt: 373, E(): 4.3e-15, (30.75% identity in 270 aa overlap); P70947|YITU from Bacillus subtilis (270 aa) FASTA scores: opt: 353, E(): 6.5e-14, (30.0% identity in 280 aa overlap); etc. Q7TVM0 No conserved hypotheticals Rv3813c NC_002945.3 Mycobrowser_v2 CDS 4260288 4260944 . + 0 Mb3880 conserved protein Mb3880, -, len: 218 aa. Equivalent to Rv3850, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Conserved hypothetical protein, equivalent to Q9CDD0|ML0068 HYPOTHETICAL PROTEIN from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071, E(): 7.2e-55, (78.35% identity in 217 aa overlap). Q7TVI5 No conserved hypotheticals Rv3850 NC_002945.3 Mycobrowser_v2 CDS 4217065 4217844 . - 0 Mb3846c possible acyltransferase Mb3846c, -, len: 259 aa. Equivalent to Rv3816c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Possible acyltransferase (EC 2.3.1.-), equivalent to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa) FASTA scores: opt: 1401, E(): 1.5e-80, (81.9% identity in 254 aa overlap). Also highly similar to many putative acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 758, E(): 2.4e-40,(51.7% identity in 234 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 312, E(): 2e-12, (29.55% identity in 237 aa overlap); O67841|AAS|AQ_2058 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE from Aquifex aeolicus (211 aa), FASTA scores: opt: 281, E(): 1.5e-10, (32.7% identity in 162 aa overlap); etc. Also highly similar to upstream ORFs O07808|Rv3815c|MTCY409.15 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (251 aa), FASTA scores: opt: 847, E(): 6.7e-46, (55.7% identity in 246 aa overlap); and O07809|Rv3814c|MTCY409.16 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 776, E(): 1.9e-41, (50.9% identity in 228 aa overlap). Q7TVL7 No intermediary metabolism and respiration Rv3816c NC_002945.3 Mycobrowser_v2 CDS 4217920 4218675 . + 0 Mb3847 possible phosphotransferase Mb3847, -, len: 251 aa. Equivalent to Rv3817, len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Possible phosphotransferase (EC 2.7.-.-), similar to many phosphotransferases e.g. O53023 KANAMYCIN MARKER from Escherichia coli (264 aa), FASTA scores: opt: 232, E(): 7.5e-08, (32.4% identity in 247 aa overlap); BAA78209|NEO NEOMYCINE PHOSPHOTRANSFERASE from Drosophila melanogaster (Fruit fly) (264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0% identity in 247 aa overlap); AAG09774 AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Vibrio cholerae (264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0% identity in 247 aa overlap); P00552|KKA2_KLEPN|NEO|KAN AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Klebsiella pneumoniae (264 aa), FASTA scores: opt: 227, E(): 1.6e-07,(32.0% identity in 247 aa overlap); etc. Q7TVL6 No intermediary metabolism and respiration Rv3817 NC_002945.3 Mycobrowser_v2 CDS 4218722 4220272 . + 0 Mb3848 unknown protein Mb3848, -, len: 516 aa. Equivalent to Rv3818, len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 516 aa overlap). Hypothetical unknown protein. Q7TVL5 No conserved hypotheticals Rv3818 NC_002945.3 Mycobrowser_v2 CDS 4220692 4222098 . - 0 Mb3850c papA2 POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA2 Mb3850c, papA2, len: 468 aa. Equivalent to Rv3820c,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 468 aa overlap). Possible papA2,conserved polyketide synthase (PKS) associated protein,highly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-ASSOCIATED PROTEIN A3 from Mycobacterium leprae (471 aa), FASTA scores: opt: 1660, E(): 2.7e-102, (53.95% identity in 456 aa overlap). Also similar to Q9F2R3|SCD65.19c HYPOTHETICAL 52.8 KDA PROTEIN from Streptomyces coelicolor (473 aa), FASTA scores: opt: 575,E(): 1.8e-30, (27.8% identity in 464 aa overlap); and weakly similar to part of other proteins. Also high similarity with other PKS-ASSOCIATED PROTEINS from Mycobacterium tuberculosis; O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt: 1694, E(): 1.5e-104, (53.8% identity in 461 aa overlap); and O07799|PAPA1|Rv3824c|MTCY409.06 (511 aa), FASTA scores: opt: 1664, E(): 1.6e-102, (53.9% identity in 462 aa overlap); and similar to C-terminal end of O53902|PAPA4|Rv1528c|MTV045.02 (165 aa), FASTA scores: opt: 186, E(): 4.1e-05, (37.9% identity in 66 aa overlap). X2BPC4,Q7TVL3 No NC_002945.3 Mycobrowser_v2 CDS 4227912 4229447 . - 0 Mb3854c papA1 conserved polyketide synthase associated protein papa1 Mb3854c, papA1, len: 511 aa. Equivalent to Rv3824c,len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Possible papA1,conserved polyketide synthase (PKS) associated protein,highly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-ASSOCIATED PROTEIN A3 from Mycobacterium leprae (471 aa), FASTA scores: opt: 1879, E(): 7.1e-111, (55.5% identity in 465 aa overlap). Also similar to Q9F2R3|SCD65.19c HYPOTHETICAL 52.8 KDA PROTEIN from Streptomyces coelicolor (473 aa), FASTA scores: opt: 476,E(): 1.7e-22, (26.7% identity in 464 aa overlap); and similar in part to Q09164|SIMA|CYSYN CYCLOSPORIN SYNTHETASE from Tolypocladium inflatum (15281 aa) FASTA scores: opt: 238, E(): 2.8e-06, (22.35% identity in 371 aa overlap). Also highly similar to other PKS-ASSOCIATED PROTEINS from Mycobacterium tuberculosis; O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt: 1862, E(): 8.4e-110, (55.95% identity in 470 aa overlap); and upstream ORF O07803|PAPA2|Rv3820c|MTCY409.10 (468 aa) FASTA scores: opt: 1664, E(): 2.5e-97, (53.9% identity in 462 aa overlap). Contains PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. X2BQ32,Q7TVK9 No NC_002945.3 Mycobrowser_v2 CDS 4222246 4222959 . + 0 Mb3851 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3851, -, len: 237 aa. Equivalent to Rv3821, len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 237 aa overlap). Probable conserved integral membrane protein, equivalent to Q49630|ML1233|B1170_F2_64 HYPOTHETICAL 24.4 KDA PROTEIN /INTEGRAL MEMBRANE PROTEIN (POTENTIAL) from Mycobacterium leprae (230 aa), FASTA scores: opt: 619, E(): 2.4e-32,(46.65% identity in 240 aa overlap). Shows some similarity to P29466|I1BC_HUMAN|CASP1|IL1BC|IL1BCE (404 aa), FASTA scores: opt: 126, E(): 0.88, (29.05% identity in 155 aa overlap). Also highly similar to P71796|Rv1517|MTCY277.39 HYPOTHETICAL 26.9 KDA PROTEIN from Mycobacterium tuberculosis (254 aa), FASTA scores: opt: 284, E(): 5.4e-11, (36.35% identity in 256 aa overlap). Start site chosen on basis of similarity to LEPB1170_F2_64 and MTCY277.39, but may extend further upstream. Q7TVL2 No cell wall and cell processes Rv3821 NC_002945.3 Mycobrowser_v2 CDS 4242509 4243084 . - 0 Mb3862c conserved protein Mb3862c, -, len: 191 aa. Equivalent to Rv3832c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 191 aa overlap). Conserved hypothetical protein, similar in part to various proteins e.g. Q9XBC9|CZA382.22c PUTATIVE RRNA METHYLASE from Amycolatopsis orientalis (259 aa), FASTA scores: opt: 196,E(): 1.3e-05, (38.2% identity in 110 aa overlap); CAC48459|SMB20059 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (259 aa), FASTA scores: opt: 188, E(): 4.3e-05, (33.8% identity in 136 aa overlap); Q98FP8|MLL3672 METHYL TRANSFERASE-LIKE PROTEIN from Rhizobium loti (Mesorhizobium loti) (264 aa), FASTA scores: opt: 180,E(): 0.00014, (32.05% identity in 156 aa overlap); etc. Q7TVK1 No conserved hypotheticals Rv3832c NC_002945.3 Mycobrowser_v2 CDS 4222994 4224208 . + 0 Mb3852 CONSERVED HYPOTHETICAL PROTEIN Mb3852, -, len: 404 aa. Equivalent to Rv3822, len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 404 aa overlap). Conserved hypothetical protein, similar in part to hypothetical proteins from Mycobacterium leprae: Q9CC62|ML1232 (358 aa) FASTA scores: opt: 601, E(): 1.1e-25, (36.7% identity in 335 aa overlap); and Q49633|B1170_F3_112 (391 aa) FASTA scores: opt: 601, E(): 1.2e-25, (36.25% identity in 347 aa overlap). Also similar to P71862|Rv3539|MTCY03C7.17c PPE FAMILY PROTEIN from Mycobacterium tuberculosis (479 aa),FASTA scores: opt: 547, E(): 1.3e-22, (38.1% identity in 281 aa overlap); O50440|Rv1184c|MTV005.20c (359 aa); O06828|Rv1430|MTCY493.24c (528 aa); O53642|Rv0159c|MTV032.02c (468 aa); etc. Q7TVL1 No conserved hypotheticals Rv3822 NC_002945.3 Mycobrowser_v2 CDS 4224533 4227802 . - 0 Mb3853c mmpL8 conserved integral membrane transport protein mmpl8 Mb3853c, mmpL8, len: 1089 aa. Equivalent to Rv3823c, len: 1089 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1089 aa overlap). Probable mmpL8, conserved integral membrane transport protein (see citation below), member of RND superfamily,equivalent to Q49619|MMLA_MYCLE|MMPL10|TP1|ML1231|B1170_C1_181 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (1008 aa),FASTA scores: opt: 2718, E(): 7.3e-149, (56.25% identity in 1028 aa overlap). Also similar to others e.g. Q9XCF6|TMTPC from Mycobacterium avium (974 aa), FASTA scores: opt: 660, E(): 2.7e-30, (28.2% identity in 1050 aa overlap); Q9XCF5|TMTPB from Mycobacterium avium (963 aa),FASTA scores: opt: 653, E(): 6.7e-30, (27.0% identity in 1014 aa overlap); Q9KH53|TMTPC from Mycobacterium smegmatis (994 aa), FASTA scores: opt: 648, E(): 1.3e-29,(28.45% identity in 1013 aa overlap); etc. Also highly similar to other mmpL proteins from Mycobacterium tuberculosis; O50439|MMLA_MYCTU|MMPL10|RV1183|MT1220|MTV005.19 (1002 aa), FASTA scores: opt: 2777, E(): 2.9e-152, (58.25% identity in 996 aa overlap); Q50585|MMLC_MYCTU|MMPL12|Rv1522c|MT1573|MTCY19G5.06 (1146 aa), FASTA scores: opt: 2433, E(): 2.1e-132, (49.9% identity in 1050 aa overlap); and similar to others e.g. P95235|MML9_MYCTU|MMPL9|Rv2339|MT2402|MTCY98.08 (962 aa),FASTA scores: opt: 651, E(): 8.8e-30, (28.6% identity in 1038 aa overlap); etc. BELONGS TO THE MMPL FAMILY. X2BPW7,Q7TVL0 No cell wall and cell processes Rv3823c NC_002945.3 Mycobrowser_v2 CDS 4229498 4235878 . - 0 Mb3855c pks2 POLYKETIDE SYNTHASE PKS2 Mb3855c, pks2, len: 2126 aa. Equivalent to Rv3825c,len: 2126 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2126 aa overlap). Probable pks2, polyketide synthase (EC undetermined), equivalent to Q9CD78|MAS|ML0139 PUTATIVE MYCOCEROSIC SYNTHASE from Mycobacterium leprae (2116 aa), FASTA scores: opt: 6828,E(): 0, (63.3% identity in 2128 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE from Mycobacterium leprae (2118 aa) FASTA scores: opt: 5220, E(): 0, (62.4% identity in 2130 aa overlap); or similar in part to others from Mycobacterium leprae e.g. Q9CB70|ML2354 POLYKETIDE SYNTHASE (1822 aa) FASTA scores: opt: 2787, E(): 2.1e-145, (34.7% identity in 2135 aa overlap). Also highly similar to Q02251|MCAS_MYCBO|MAS MYCOCEROSIC ACID SYNTHASE from Mycobacterium bovis (2110 aa), FASTA scores: opt: 3495,E(): 2.6e-184, (61.65% identity in 2130 aa overlap). Also highly similar to other polyketide synthases from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 (2108 aa) FASTA scores: opt: 9576, E(): 0, (69.8% identity in 2124 aa overlap); P96291|MAS|Rv2940c|MTCY24G1.09|MTCY19H9.08c (2111 aa), FASTA scores: opt: 3518, E(): 1.4e-185, (64.05% identity in 2126 aa overlap); O50437|PKS4|Rv1181|MTV005.17 (1582 aa), FASTA scores: opt: 3461, E(): 1.6e-182, (64.55% identity in 1609 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site and PS00012 Phosphopantetheine attachment site. X2BPD2,Q7TVK8 No NC_002945.3 Mycobrowser_v2 CDS 4236085 4237839 . + 0 Mb3856 fadD23 probable fatty-acid-amp ligase fadd23 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb3856, fadD23, len: 584 aa. Equivalent to Rv3826,len: 584 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 584 aa overlap). Probable fadD23,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to P71495 ACYL-COA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2571, E(): 4.4e-146, (66.15% identity in 576 aa overlap); Q9CD79|FADD28|ML0138 ACYL-COA SYNTHETASE from Mycobacterium leprae (579 aa) FASTA scores: opt: 2520, E(): 4.9e-143, (65.2% identity in 575 aa overlap); P54200|FD21_MYCLE PUTATIVE FATTY-ACID--COA LIGASE (ACYL-COA SYNTHETASE) from Mycobacterium leprae (579 aa), FASTA scores: opt: 2330, E(): 1.1e-131, (60.2% identity in 578 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P96290|FADD28|Rv2941|MTCY24G1.08c (580 aa), FASTA scores: opt: 2587, E(): 4.9e-147, (66.5% identity in 576 aa overlap); O53903|FADD24|Rv1529|MTV045.03 (584 aa), FASTA scores: opt: 2457, E(): 2.9e-139, (63.35% identity in 584 aa overlap); Q50586|FADD25|Rv1521|MT1572|MTCY19G5.07 (583 aa) FASTA scores: opt: 2389, E(): 3.3e-135, (61.45% identity in 581 aa overlap); etc. X2BPQ7,Q7TVK7 No NC_002945.3 Mycobrowser_v2 CDS 4237836 4239062 . - 0 Mb3857c possible transposase Mb3857c, -, len: 408 aa. Equivalent to Rv3827c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 408 aa overlap). Possible transposase within IS1537 element, similar to several transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|DR1651|DR1933 TRANSPOSASE from Deinococcus radiodurans(408 aa) FASTA scores: opt: 302, E(): 3.9e-12, (30.75% identity in 358 aa overlap); Q9RXX7|DR0178 PUTATIVE TRANSPOSASE from Deinococcus radiodurans (409 aa), FASTA scores: opt: 297,E(): 8.2e-12, (31.1% identity in 360 aa overlap); P73816|SLR2062 TRANSPOSASE from Synechocystis sp. strain PCC 6803 (400 aa), FASTA scores: opt: 296, E(): 9.3e-12,(30.05% identity in 353 aa overlap); etc. Highly similar to proteins from Mycobacterium tuberculosis e.g. O33333|Rv2791c|MTV002.56c TRANSPOSASE (459 aa) FASTA scores: opt: 2211, E(): 9.4e-136, (87.75% identity in 367 aa overlap); P95117|Rv2978c|MTCY349.09 HYPOTHETICAL 51.4 KDA PROTEIN (459 aa), FASTA scores: opt: 2165, E(): 9e-133, (85.85% identity in 367 aa overlap); Q10809|YS85_MYCTU|Rv2885c|MT2953|MTCY274.16c HYPOTHETICAL 51.3 KDA PROTEIN (460 aa), FASTA scores: opt: 2127, E(): 2.6e-130, (83.95% identity in 368 aa overlap); O0777|Rv0606|MTCY19H5.16c PROBABLE TRANSPOSASE (FRAGMENT) (247 aa), FASTA scores: opt: 1405, E(): 9.3e-84, (85.3% identity in 238 aa overlap); etc. Q7TVK6 No insertion seqs and phages Rv3827c NC_002945.3 Mycobrowser_v2 CDS 4239059 4239670 . - 0 Mb3858c POSSIBLE RESOLVASE Mb3858c, -, len: 203 aa. Equivalent to Rv3828c, len 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Possible resolvase within IS1537 element, similar to others e.g. Q97X40|SSO1915 FIRST ORF IN TRANSPOSON ISC1913 from Sulfolobus solfataricus (213 aa), FASTA scores: opt: 275,E(): 1.6e-11, (30.6% identity in 196 aa overlap); Q9V1M0|PAB2076 RESOLVASE RELATED PROTEIN from Pyrococcus abyssi (212 aa), FASTA scores: opt: 254, E(): 4.2e-10,(29.95% identity in 197 aa overlap); Q9RMU7|ORFA PUTATIVE TRANSPOSASE (BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS) from elicobacter pylori (Campylobacter pylori) (217 aa), FASTA scores: opt: 243, E(): 2.3e-09, (31.8% identity in 154 aa overlap); etc. Also highly similar to proteins from Mycobacterium tuberculosis e.g. O33334|Rv2792c|MTV002.57c RESOLVASE (193 aa), FASTA scores: opt: 970, E(): 1.5e-58, (79.25% identity in 193 aa overlap); O07773|Rv0605|MTCY19H5.17c PUTATIVE RESOLVASE (202 aa), FASTA scores: opt: 964, E(): 4e-58, (76.25% identity in 202 aa overlap); P95116|Rv2979c|MTCY349.08 HYPOTHETICAL 21.4 KDA PROTEIN (194 aa), FASTA scores: opt: 895, E(): 1.8e-53, (74.75% identity in 194 aa overlap); Q10831|YS86_MYCTU|Rv2886c|MT2954|MTCY274.17c HYPOTHETICAL 31.9 KDA PROTEIN (295 aa), FASTA scores: opt: 826, E(): 1.1e-48, (66.2% identity in 204 aa overlap) (similarity only at C-terminus); etc. Contains PS00397 Site-specific recombinases active site. Possible helix-turn-helix motif from aa 11-32, Score 1305 (+3.63 SD). Q7TVK5 No insertion seqs and phages Rv3828c NC_002945.3 Mycobrowser_v2 CDS 4239671 4241281 . - 0 Mb3859c probable dehydrogenase Mb3859c, -, len: 536 aa. Equivalent to Rv3829c, len 536 aa, from Mycobacetrium tuberculosis strain H37Rv,(99.8% identity in 536 aa overlap). Probable oxidoreductase dehydrogenase (EC 1.-.-.-), similar to others e.g. Q9A3T1|CC3121 PHYTOENE DEHYDROGENASE-RELATED PROTEIN from Caulobacter crescentus (543 aa), FASTA scores: opt: 607, E(): 9.2e-28, (28.25% identity in 552 aa overlap); Q98FP6|MLR3676 PHYTOENE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (521 aa), FASTA scores: opt: 605, E(): 1.2e-27, (28.2% identity in 546 aa overlap); Q97W24|SSO2422 PHYTOENE DEHYDROGENASE RELATED PROTEIN from Sulfolobus solfataricus (518 aa), FASTA scores: opt: 388, E(): 4.4e-15, (27.35% identity in 530 aa overlap); Q98BS8|MLL5443 PROBABLE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (524 aa), FASTA scores: opt: 374, E(): 2.9e-14, (24.35% identity in aa overlap); etc. Also similar to MTCY493.22c|Rv1432|MTCY493.22c HYPOTHETICAL 50.5 KDA PROTEIN (probable dehydrogenase) from Mycobacterium tuberculosis (25.1% identity in 295 aa overlap). Q7TVK4 No intermediary metabolism and respiration Rv3829c NC_002945.3 Mycobrowser_v2 CDS 4241329 4241958 . - 0 Mb3860c TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb3860c, -, len: 209 aa. Equivalent to Rv3830c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable transcriptional regulator tetR family, similar to others e.g. P39885|TCMR_STRGA TETRACENOMYCIN C TRANSCRIPTIONAL REPRESSOR from Streptomyces glaucescens (226 aa) FASTA scores: opt: 255, E(): 6.1e-10, (33.65% identity in 202 aa overlap); Q9RDR0|SC4A7.02 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (227 aa) FASTA scores: opt: 230, E(): 2.8e-08, (30.05% identity in 213 aa overlap); Q9EWU3|3SC5B7.06 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 221, E(): 1.2e-07, (32.05% identity in 181 aa overlap); Q9AJ68|BUTR PUTATIVE TRANSCRIPTIONAL REPRESSOR from Streptomyces cinnamonensis (268 aa), FASTA scores: opt: 216, E(): 2.7e-07, (37.8% identity in 119 aa overlap); etc. Contains possible helix-turn-helix motif from aa 33-54, Score 1699 (+4.97 SD). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TVK3 No regulatory proteins Rv3830c NC_002945.3 Mycobrowser_v2 CDS 4243140 4243931 . + 0 Mb3863 TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARAC-FAMILY) Mb3863, -, len: 263 aa. Equivalent to Rv3833, len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Probable transcriptional regulator belonging to araC family,similar to others e.g. Q9KYN4|SC9H11.05 PUTATIVE ARAC-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42,(50.45% identity in 232 aa overlap); Q9HXH2|PA3830 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26,(34.85% identity in 238 aa overlap); Q9HX87|PA3927 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 496, E(): 1.3e-25,(36.45% identity in 266 aa overlap); P76241|YEAM_ECOLI|B1790 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 (273 aa) FASTA scores: opt: 388, E(): 1.9e-18, (30.5% identity in 223 aa overlap); etc. Contains probable helix-turn-helix motif from aa 164-185, Score 2014 (+6.05 SD). SEEMS TO BELONG TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7TVK0 No regulatory proteins Rv3833 NC_002945.3 Mycobrowser_v2 CDS 4260956 4261240 . + 0 Mb3881 POSSIBLE MEMBRANE PROTEIN Mb3881, -, len: 94 aa. Equivalent to Rv3851, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Possible membrane protein. Q7TVI4 No cell wall and cell processes Rv3851 NC_002945.3 Mycobrowser_v2 CDS 4243928 4245187 . - 0 Mb3864c serS SERYL-TRNA SYNTHETASE SERS (SERINE--TRNA LIGASE) (SERRS) (SERINE TRANSLASE) Mb3864c, serS, len: 419 aa. Equivalent to Rv3834c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 419 aa overlap). Probable serS,seryl-tRNA synthetase (EC 6.1.1.11), equivalent to Q9CDC1|SERS|ML0082 PUTATIVE SERYL-TRNA SYNTHASE from Mycobacterium leprae (417 aa), FASTA scores: opt: 2361,E(): 8.5e-138, (85.8% identity in 416 aa overlap). Also highly similar many e.g. Q9ZBX1|SYS_STRCO|SERS|SCD78.28c from Streptomyces coelicolor (425 aa), FASTA scores: opt: 1594, E(): 1.2e-90, (59.75% identity in 425 aa overlap); Q9X199|SYS_THEMA|SERS|TM1379 from Thermotoga maritima (425 aa), FASTA scores: opt: 1083, E(): 3.3e-59, (43.3% identity in 425 aa overlap); P37464|SYS_BACSU|SERS from Bacillus subtilis (425 aa), FASTA scores: opt: 1015, E(): 5e-55, (39.3% identity in 425 aa overlap); etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. X2BQ34,P67562 No NC_002945.3 Mycobrowser_v2 CDS 4246674 4247024 . + 0 Mb3866 CONSERVED HYPOTHETICAL PROTEIN Mb3866, -, len: 116 aa. Similar to Rv3836, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 115 aa overlap). Conserved hypothetical protein, highly similar to Q9RKJ2|SCD25.30 HYPOTHETICAL 13.1 KDA PROTEIN from Streptomyces coelicolor (116 aa),FASTA scores: opt: 395, E(): 3.3e-19, (54.4% identity in 114 aa overlap); and similar to CAC47753|SMC0379 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (144 aa) FASTA scores: opt: 194,E(): 6e-06, (33.05% identity in 109 aa overlap); and Q98E37|MLL4425 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 184,E(): 3.7e-05, (29.75% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa). Q7TVJ8 No NC_002945.3 Mycobrowser_v2 CDS 4247978 4248943 . - 0 Mb3868c pheA prephenate dehydratase phea Mb3868c, pheA, len: 321 aa. Equivalent to Rv3838c,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 321 aa overlap). Possible pheA,prephenate dehydratase (EC 4.2.1.51) (see citation below),equivalent to Q9CDC4|PHEA|ML0078 PUTATIVE PREPHENATE DEHYDRATASE from Mycobacterium leprae (322 aa), FASTA scores: opt: 1690, E(): 1.3e-93, (84.25% identity in 311 aa overlap). Also highly similar to others e.g. P10341|PHEA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (315 aa), FASTA scores: opt: 843,E(): 4e-43, (45.8% identity in 308 aa overlap); Q9ZBX0|SCD78.29c from Streptomyces coelicolor (310 aa),FASTA scores: opt: 820, E(): 9.2e-42, (46.45% identity in 312 aa overlap); Q44104|PHEA_AMYME|PDT from Amycolatopsis methanolica (304 aa), FASTA scores: opt: 707, E(): 4.9e-35, (45.7% identity in 313 aa overlap); etc. Contains PS00858 Prephenate dehydratase signature 2. X2BPX4,Q7TVJ6 No NC_002945.3 Mycobrowser_v2 CDS 4249841 4250254 . + 0 Mb3870 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb3870, -, len: 137 aa. Equivalent to Rv3840, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Possible transcriptional regulator, highly similar in part to PSR PROTEINS (PENICILLIN BINDING PROTEIN REPRESSORS) e.g. Q47828|PSR PSR PROTEIN from Enterococcus hirae (293 aa) FASTA scores: opt: 221, E(): 2.2e-07, (41.65% identity in 108 aa overlap); O86213|PSRFM PSRFM PROTEIN (FRAGMENT) from Enterococcus hirae (171 aa), FASTA scores: opt: 202,E(): 2.4e-06, (40.75% identity in 108 aa overlap); Q47865|PSR PENICILLIN BINDING PROTEIN REPRESSOR from Enterococcus hirae (148 aa), FASTA scores: opt: 201, E(): 2.5e-06, (51.65% identity in 60 aa overlap); etc. Also highly similar in part to other transcriptional regulators e.g. BAB57524|MSRR PEPTIDE METHIONINE SULFOXIDE REDUCTASE REGULATOR from Staphylococcus aureus subsp. aureus Mu50 (327 aa), FASTA scores: opt: 195, E(): 1.2e-05, (36.7% identity in 109 aa overlap); Q99Q02|MSRR|SA1195 PEPTIDE METHIONINE SULFOXIDE REDUCTASE REGULATOR from Staphylococcus aureus subsp. aureus N315, and Staphylococcus aureus (327 aa), FASTA scores: opt: 192,E(): 1.9e-05, (36.7% identity in 109 aa overlap); Q9K6Q8|LYTR|BH3670 ATTENUATOR FOR LYTABC AND LYTR EXPRESSION from Bacillus halodurans (304 aa), FASTA scores: opt: 171, E(): 0.00041, (34.5% identity in 113 aa overlap); etc. Q7TVJ4 No regulatory proteins Rv3840 NC_002945.3 Mycobrowser_v2 CDS 4250452 4250997 . + 0 Mb3871 bfrB bacterioferritin bfrb Mb3871, bfrB, len: 181 aa. Equivalent to Rv3841,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Possible bfrB,bacterioferritin, similar to other ferritin or hypothetical proteins e.g. O26261|MTH158|RSGA FERRITIN LIKE PROTEIN from Methanothermobacter thermautotrophicus (171 aa), FASTA scores: opt: 277, E(): 6.6e-11, (30.1% identity in 166 aa overlap); Q99SZ3|SA1709 HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus N315 (166 aa), FASTA scores: opt: 275, E(): 8.7e-11, (33.35% identity in 156 aa overlap); Q9X0L2|TM1128 FERRITIN from Thermotoga maritima (164 aa), FASTA scores: opt: 247, E(): 5.3e-09, (25.65% identity in 156 aa overlap); Q9KDT7|BH1124 FERRITIN from Bacillus halodurans (169 aa),FASTA scores: opt: 246, E(): 6.3e-09, (28.95% identity in 152 aa overlap); O29424|AF0834 PUTATIVE FERRITIN from Archaeoglobus fulgidu (169 aa), FASTA scores: opt: 246,E(): 6.3e-09, (28.95% identity in 152 aa overlap); etc. Also shows similarity with Rv1876|MTCY180.42|BFRA PROBABLE BACTERIOFERRITIN from Mycobacterium tuberculosis (159 aa). SEEMS BELONG TO THE BACTERIOFERRITIN FAMILY. Q7TVJ3 No intermediary metabolism and respiration Rv3841 NC_002945.3 Mycobrowser_v2 CDS 4251012 4251836 . - 0 Mb3872c glpQ1 PROBABLE GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLPQ1 (GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE) Mb3872c, glpQ1, len: 274 aa. Equivalent to Rv3842c,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Probable glpQ1,glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46),equivalent to Q9CDC5|GLPQ|ML0074 PUTATIVE GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Mycobacterium leprae (271 aa), FASTA scores: opt: 1635,E(): 1.9e-100, (88.85% identity in 269 aa overlap). Also highly similar to others e.g. CAC44700|SCBAC25E3.13c PUTATIVE PHOSPHODIESTERASE from Streptomyces coelicolor (275 aa), FASTA scores: opt: 413, E(): 5.7e-20, (48.05% identity in 258 aa overlap); P37965|GLPQ_BACSU GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Bacillus subtilis (293 aa), FASTA scores: opt: 405, E(): 2e-19,(31.3% identity in 249 aa overlap); Q99VC9|GLPQ|SA0820 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Staphylococcus aureus subsp. aureus N315 (309 aa) FASTA scores: opt: 341, E(): 3.5e-15, (29.3% identity in 273 aa overlap); etc. Q7TVJ2 No NC_002945.3 Mycobrowser_v2 CDS 4255048 4255539 . + 0 Mb3874 possible transposase Mb3874, -, len: 163 aa. Equivalent to Rv3844, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Possible transposase,identical to P96234|Rv3348|MTV004.04 PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis. Also some similarity with others e.g. N-terminal part of P19834|YI11_STRCL INSERTION ELEMENT IS116 HYPOTHETICAL 44.8 KDA PROTEIN from Streptomyces clavuligerus (399 aa) FASTA scores: opt: 146,E(): 0.017, (29.1% identity in 158 aa overlap). Q7TTJ5 No insertion seqs and phages Rv3844 NC_002945.3 Mycobrowser_v2 CDS 4279090 4279641 . + 0 Mb3897 esph esx-1 secretion-associated protein esph Mb3897, -, len: 183 aa. Equivalent to Rv3867, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, highly similar to the hypothetical proteins from Mycobacterium leprae Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403, E(): 1.8e-18, (48.2% identity in 166 aa overlap); Q49730|ML0407|B1620_C3_264|MLCL383.03 (216 aa), FASTA scores: opt: 517, E(): 1.7e-25, (51.45% identity in 175 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 403, E(): 3.4e-18, (48.2% identity in 166 aa overlap). Also highly similar to O06269|Rv3614c|MTCY07H7B.08 HYPOTHETICAL 19.8 KDA PROTEIN from Mycobacterium tuberculosis (184 aa), FASTA scores: opt: 559, E(): 3.4e-28, (54.35% identity in 173 aa overlap). Q7TVG9 No cell wall and cell processes Rv3867 NC_002945.3 Mycobrowser_v2 CDS 4256977 4257600 . + 0 Mb3876 sodA SUPEROXIDE DISMUTASE [FE] SODA Mb3876, sodA, len: 207 aa. Equivalent to Rv3846,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 207 aa overlap). sodA (alternate gene names: sodB, sod), superoxyde dismutase (EC 1.15.1.1) (see citations below), equivalent to many e.g. P47201|SODM_MYCAV|SODA|SOD from Mycobacterium avium (206 aa), FASTA scores: opt: 1210, E(): 1.8e-73, (82.5% identity in 206 aa overlap); Q9F9R1|SOD from Mycobacterium paratuberculosis (207 aa), FASTA scores: opt: 1207, E(): 2.9e-73, (81.65% identity in 207 aa overlap); O86165|SODM_MYCLP|SODA|SOD from Mycobacterium lepraemurium (206 aa), FASTA scores: opt: 1204, E(): 4.5e-73, (82.05% identity in 206 aa overlap); P13367|SODM_MYCLE|SODA|ML0072 from Mycobacterium leprae (206 aa), FASTA scores: opt: 1169, E(): 9.6e-71, (80.5% identity in 205 aa overlap); etc. Contains PS00088 Manganese and iron superoxide dismutases signature. BELONGS TO THE IRON/MANGANESE SUPEROXIDE DISMUTASE FAMILY. ALTHOUGH FOUND EXTRACELLULARLY, NO SIGNAL SEQUENCE IS PRESENT. AN ALTERNATIVE SECRETORY PATHWAY MAY BE USED. X2BPS3,Q7TVI9 No virulence, detoxification, adaptation Rv3846 NC_002945.3 Mycobrowser_v2 CDS 4257811 4258344 . + 0 Mb3877 HYPOTHETICAL PROTEIN Mb3877, -, len: 177 aa. Equivalent to Rv3847, len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). Conserved hypothetical protein, equivalent to Q9CDC7|ML0071 HYPOTHETICAL PROTEIN from Mycobacterium leprae (177 aa) FASTA scores: opt: 1149, E(): 1.6e-64, (96.6% identity in 177 aa overlap); and Q9F9R0 HYPOTHETICAL 18.5 KDA PROTEIN from Mycobacterium paratuberculosis (177 aa), FASTA scores: opt: 1139, E(): 6.8e-64, (96.6% identity in 177 aa overlap). Q7TVI8 No conserved hypotheticals Rv3847 NC_002945.3 Mycobrowser_v2 CDS 4287395 4288501 . + 0 Mb3903 PPE68 ppe family protein ppe68 Mb3903, PPE68, len: 368 aa. Equivalent to Rv3873,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 368 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O33085|ML0051|MLCB628.14c from Mycobacterium leprae (302 aa), FASTA scores: opt: 656, E(): 2.8e-24,(46.2% identity in 288 aa overlap); and O53691|Rv0286|MTV035.14 (513 aa), FASTA scores: opt: 566,E(): 7.8e-20, (35.25% identity in 363 aa overlap). Q7TVG3 No NC_002945.3 Mycobrowser_v2 CDS 4258599 4259507 . + 0 Mb3878 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3878, -, len: 302 aa. Equivalent to Rv3848, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Probable conserved transmembrane protein, similar to hypothetical (transmembrane) proteins e.g. Q9HVG2|PA4629 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (192 aa), FASTA scores: opt: 304, E(): 5.3e-11, (35.05% identity in 174 aa overlap); Q9A5S7|CC2370 HYPOTHETICAL PROTEIN from Caulobacter crescentus (207 aa), FASTA scores: opt: 285,E(): 7.4e-10, (29.9% identity in 184 aa overlap); Q9KY43|SCC8A.05c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (193 aa), FASTA scores: opt: 245,E(): 1.6e-07, (32.8% identity in 195 aa overlap); etc. Q7TVI7 No cell wall and cell processes Rv3848 NC_002945.3 Mycobrowser_v2 CDS 4259772 4260170 . + 0 Mb3879 espr esx-1 transcriptional regulatory protein espr Mb3879, -, len: 132 aa. Equivalent to Rv3849, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Conserved hypothetical protein, equivalent to Q9CDC9|ML0069 HYPOTHETICAL PROTEIN from Mycobacterium leprae (132 aa) FASTA scores: opt: 724, E(): 8.7e-41, (83.95% identity in 131 aa overlap). Q7TVI6 No regulatory proteins Rv3849 NC_002945.3 Mycobrowser_v2 CDS 4261347 4261751 . + 0 Mb3882 hns POSSIBLE HISTONE-LIKE PROTEIN HNS Mb3882, hns, len: 134 aa. Equivalent to Rv3852,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 HISTONE-LIKE PROTEIN from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 HISTONE H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183, E(): 0.091, (34.85% identity in 109 aa overlap); etc. Q7TVI3 No information pathways Rv3852 NC_002945.3 Mycobrowser_v2 CDS 4261768 4262241 . + 0 Mb3883 rraa regulator of rnase e activity a rraa Mb3883, menG, len: 157 aa. Equivalent to Rv3853,len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 157 aa overlap). Probable menG,S-adenosylmethionine:2-demethylmenaquinone methyltransferase (EC 2.1.-.-), equivalent to Q9CDD2|MENG|ML0066 PUTATIVE S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLTRANSFERASE from Mycobacterium leprae (157 aa) FASTA scores: opt: 896, E(): 1.3e-49, (87.1% identity in 155 aa overlap). Also highly similar to others e.g. Q9S4U0|MENG from Pseudomonas fluorescens (163 aa), FASTA scores: opt: 481, E(): 1.7e-23, (47.0% identity in 149 aa overlap); Q9RW10|DR0859 from Deinococcus radiodurans (160 aa) FASTA scores: opt: 456, E(): 6.3e-22, (45.75% identity in 153 aa overlap); P32165|MENG_ECOLI|B3929|Z5476|ECS4856 from Escherichia coli strain K12 (161 aa), FASTA scores: opt: 428, E(): 3.7e-20, (45.65% identity in 149 aa overlap); etc. X2BPY0,P0A667 No regulatory proteins Rv3853 NC_002945.3 Mycobrowser_v2 CDS 4262277 4263746 . - 0 Mb3884c ethA MONOOXYGENASE ETHA Mb3884c, ethA, len: 489 aa. Equivalent to Rv3854c,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 489 aa overlap). ethA (alternate gene names: aka or etaA), monooxygenase required for activation of the pro-drug ethionamide (EC 1.-.-.-) (see citations below), highly similar to other monooxygenases e.g. Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 1959,E(): 2.9e-114, (57.6% identity in 481 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 1771, E(): 2.2e-102, (53.75% identity in 480 aa overlap); Q9A8K5|CC1348 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (499 aa), FASTA scores: opt: 1385,E(): 1.4e-78, (43.2% identity in 486 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa) FASTA scores: opt: 1692, E(): 1.1e-97, (49.7% identity in 489 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa), FASTA scores: opt: 1571,E(): 3.7e-90, (49.05% identity in 471 aa overlap); O69708|Rv3741c|MTV025.089c POSSIBLE OXIDOREDUCTASE (probably second part of a two component monooxygenase) (224 aa), FASTA scores: opt: 542, E(): 1.7e-26, (50.0% identity in 162 aa overlap); etc. X2BQ38,Q7TVI2 No NC_002945.3 Mycobrowser_v2 CDS 4263822 4264472 . + 0 Mb3885 ethR TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR Mb3885, ethR, len: 216 aa. Equivalent to Rv3855,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). ethR (alternate gene names: aka or etaR), regulatory protein tetR family,involved in ethionamide sensitivity/resistance, negatively controls neighbouring ethA (Rv3854c, MTCY01A6.14; alternate gene names: aka etaA) (see citations below). Equivalent to Q9CDD3|ML0064 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (214 aa), FASTA scores: opt: 1017, E(): 7e-62, (77.0% identity in 213 aa overlap). Also similar to other transcriptional regulator e.g. Q9S1R1|SCJ9A.09 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (204 aa), FASTA scores: opt: 305, E(): 1.2e-13, (34.5% identity in 200 aa overlap); Q9KYT9|SCE22.24 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR (FRAGMENT) from Streptomyces coelicolor (244 aa), FASTA scores: opt: 179, E(): 4.9e-05,(35.5% identity in 93 aa overlap); Q9RUK2|DR1384 TRANSCRIPTIONAL REGULATOR (TETR FAMILY) from Deinococcus radiodurans (196 aa), FASTA scores: opt: 167, E(): 0.00026, (41.75% identity in 79 aa overlap); etc. Also similar to P95100|Rv3058c|MTCY22D7.23 HYPOTHETICAL 23.8 KDA PROTEIN from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 261, E(): 1.2e-10, (31.65% identity in 221 aa overlap); and O08377|Rv1534|MTCY07A7A.03 HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium tuberculosis (225 aa),FASTA scores: opt: 164, E(): 0.00047, (25.5% identity in 248 aa overlap). Contains helix-turn-helix motif at aa 45-66, Score 1320 (+3.68 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. X2BPH1,Q7TVI1 No regulatory proteins Rv3855 NC_002945.3 Mycobrowser_v2 CDS 4264674 4265681 . - 0 Mb3886c CONSERVED HYPOTHETICAL PROTEIN Mb3886c, -, len: 335 aa. Equivalent to Rv3856c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Conserved hypothetical protein, highly similar to various proteins from diverse organisms e.g. Q9EWR3|3SCF60.21 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (372 aa) FASTA scores: opt: 1286, E(): 2.4e-73, (64.0% identity in 336 aa overlap); P72464|ORF1 from Streptomyces lividans (343 aa), FASTA scores: opt: 1275, E(): 1.1e-72, (60.1% identity in 336 aa overlap); Q9K899|BH3107 DNA-DEPENDENT DNA POLYMERASE BETA CHAIN from Bacillus halodurans (571 aa), FASTA scores: opt: 592, E(): 1.2e-29, (39.15% identity in 240 aa overlap); etc. Q7TVI0 No conserved hypotheticals Rv3856c NC_002945.3 Mycobrowser_v2 CDS 4265690 4265887 . - 0 Mb3887c POSSIBLE MEMBRANE PROTEIN Mb3887c, -, len: 65 aa. Equivalent to Rv3857c, len: 65 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 65 aa overlap). Possible membrane protein. Q7TVH9 No cell wall and cell processes Rv3857c NC_002945.3 Mycobrowser_v2 CDS 4266312 4267778 . - 0 Mb3888c gltD probable nadh-dependent glutamate synthase (small subunit) gltd (l-glutamate synthase) (l-glutamate synthetase) (nadh-glutamate synthase) (glutamate synthase (nadh)) (glts beta chain) (nadph-gogat) Mb3888c, gltD, len: 488 aa. Equivalent to Rv3858c,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Probable gltD, small subunit of NADH-dependent glutamate synthase (EC 1.4.1.13), equivalent to Q9CDD4|GLTD|ML0062 NADH-DEPENDENT GLUTAMATE SYNTHASE SMALL SUBUNIT from Mycobacterium leprae (488 aa), FASTA scores: opt: 2997, E(): 1e-166, (87.7% identity in 488 aa overlap). Also highly similar to many e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487 aa), FASTA scores: opt: 2152, E(): 1.2e-117, (63.85% identity in 487 aa overlap); Q9KPJ3|VC2374 from Vibrio cholerae (489 aa), FASTA scores: opt: 1699, E(): 2.5e-91,(51.75% identity in 487 aa overlap); Q03460|GLSN_MEDSA from Medicago sativa (Alfalfa) (2194 aa), FASTA scores: opt: 1322, E(): 6.2e-69, (54.45% identity in 485 aa overlap); P09832|GLTD_ECOLI from strain (471 aa) FASTA scores: opt: 889, E() : 0, (37.4% identity in 473 aa overlap); etc. SIMILAR TO OTHER GLUTAMATE SYNTHASES. COFACTOR: FAD (BY SIMILARITY). Q7TVH8 No NC_002945.3 Mycobrowser_v2 CDS 4273050 4274222 . + 0 Mb3890 conserved protein Mb3890, -, len: 390 aa. Equivalent to Rv3860, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 390 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 (586 aa),FASTA scores: opt: 484, E(): 5.5e-14, (29.95% identity in 407 aa overlap); O33082|MLCB628.11c (478 aa) FASTA scores: opt: 484, E(): 4.8e-14, (29.95% identity in 407 aa overlap); etc. Also some similarity with O86637|SC3C3.03c HYPOTHETICAL 112.1 KDA PROTEIN from Streptomyces coelicolor(1083 aa), FASTA scores: opt: 483, E(): 9.6e-14,(30.45% identity in 404 aa overlap). And some similarity with other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O05456|Rv3888c|MTCY15F10.24 HYPOTHETICAL 37.7 KDA PROTEIN (341 aa), FASTA scores: opt: 603, E(): 2.8e-19, (35.2% identity in 284 aa overlap); O06396|Rv0530|MTCY25D10.09 HYPOTHETICAL 43.0 KDA PROTEIN (405 aa), FASTA scores: opt: 538, E(): 2e-16, (31.0% identity in 371 aa overlap); O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 475,E(): 1.5e-13, (30.2% identity in 391 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TVH6 No conserved hypotheticals Rv3860 NC_002945.3 Mycobrowser_v2 CDS 4274444 4274794 . - 0 Mb3892c whiB6 possible transcriptional regulatory protein whib-like whib6 Mb3892c, whiB6, len: 116 aa. Equivalent to Rv3862c,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). Possible whiB6,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Shows similarity with Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL REGULATOR WHIB7 from Mycobacterium leprae (89 aa) FASTA scores: opt: 112, E(): 0.49, (41.2% identity in 51 aa overlap). Some similarity to Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa) FASTA scores: opt: 129, E(): 0.038, (32.95% identity in 85 aa overlap); AAK47632|MT3290.1 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (96 aa), FASTA scores: opt: 126, E(): 0.058, (33.35% identity in 84 aa overlap); Q9FC80|SC4B10.07 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (88 aa), FASTA scores: opt: 119, E(): 0.16, (44.65% identity in 70 aa overlap); Q9K4K8|SC5F8.16c REGULATORY PROTEIN from Streptomyces coelicolor (83 aa), FASTA scores: opt: 114,E(): 0.34, (37.05% identity in 54 aa overlap); etc. Q7TVH4 No NC_002945.3 Mycobrowser_v2 CDS 4275121 4276299 . + 0 Mb3893 unknown alanine rich protein Mb3893, -, len: 392 aa. Equivalent to Rv3863, len: 392 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 392 aa overlap). Hypothetical unknown ala-rich protein. Q7TVH3 No conserved hypotheticals Rv3863 NC_002945.3 Mycobrowser_v2 CDS 4276542 4277798 . + 0 Mb3894 espe esx-1 secretion-associated protein espe Mb3894, -, len: 418 aa. Equivalent to Rv3864, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(96.2% identity in 418 aa overlap). Conserved hypothetical protein, similar to Q49722|ML0405|B1620_C2_213|MLCL383.01 HYPOTHETICAL 40.8 KDA PROTEIN from Mycobacterium leprae (394 aa) FASTA scores: opt: 397, E(): 1.2e-12, (31.0% identity in 410 aa overlap). Also similar to various proteins from several organisms e.g. Q9VYF9|CG12723 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (450 aa), FASTA scores: opt: 291, E(): 2.3e-07,(34.6% identity in 130 aa overlap); Q98UE3 PROCOLLAGEN ALPHA1(III) (FRAGMENT) from Xenopus laevis (African clawed frog) (117 aa) FASTA scores: opt: 257, E(): 3.6e-06,(41.75% identity in 103 aa overlap); P27393|CA24_ASCSU COLLAGEN ALPHA 2(IV) CHAIN PRECURSOR from Ascaris suum (Pig roundworm) (Ascaris lumbricoides) (1763 aa), FASTA scores: opt: 273, E(): 5.7e-06, (32.1% identity in 240 aa overlap); etc. Also similar to O06267|Rv3616c|MTCY07H7B.06 (392 aa) FASTA scores: opt: 389, E(): 3e-12, (31.6% identity in 399 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 36 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa). Q7TVH2 No cell wall and cell processes Rv3864 NC_002945.3 Mycobrowser_v2 CDS 4277886 4278197 . + 0 Mb3895 espf esx-1 secretion-associated protein espf Mb3895, -, len: 103 aa. Equivalent to Rv3865, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Conserved hypothetical protein, showing some similarity to O06268|Rv3615c|MTCY07H7B.07 HYPOTHETICAL 10.8 KDA PROTEIN from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 198, E(): 7.5e-07, (36.25% identity in 102 aa overlap); Q49723|ML0406|B1620_C2_214|MLCL383.02 HYPOTHETICAL 11.1 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 154, E(): 0.00071, (31.05% identity in 103 aa overlap). Q7TVH1 No cell wall and cell processes Rv3865 NC_002945.3 Mycobrowser_v2 CDS 4278200 4279051 . + 0 Mb3896 espg1 esx-1 secretion-associated protein espg1 Mb3896, -, len: 283 aa. Equivalent to Rv3866, len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Conserved hypothetical protein. N-terminal end highly similar to O33091|MLCB628.20c HYPOTHETICAL 13.1 KDA PROTEIN from Mycobacterium leprae (122 aa), FASTA scores: opt: 260,E(): 2.1e-09, (43.6% identity in 117 aa overlap); and C-terminal end highly similar to O33090|MLCB628.19c HYPOTHETICAL 36.7 KDA PROTEIN from Mycobacterium leprae (338 aa), FASTA scores: opt: 540, E(): 1.4e-26, (54.5% identity in 156 aa overlap). Also similar to Q9CD34|ML2530 POSSIBLE DNA-BINDING PROTEIN from Mycobacterium leprae (289 aa), FASTA scores: opt: 146, E(): 0.058, (28.25% identity in 269 aa overlap) and O53694|Rv0289|MTV035.17 HYPOTHETICAL 31.6 KDA PROTEIN from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 133, E(): 0.39,(28.15% identity in 277 aa overlap). Q7TVH0 No cell wall and cell processes Rv3866 NC_002945.3 Mycobrowser_v2 CDS 4279634 4281355 . + 0 Mb3898 ecca1 esx conserved component ecca1. esx-1 type vii secretion system protein. Mb3898, -, len: 573 aa. Equivalent to Rv3868, len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 573 aa overlap). Member of the CBXX/CFQX family of hypothetical proteins; C-terminal end is highly similar to many e.g. P40118|CBXC_ALCEU|CBXXC|CFXXC CBXX PROTEIN (317 aa) FASTA scores: opt: 572, E(): 3e-24, (42.7% identity in 294 aa overlap); CAC48589 PROBABLE CBBX PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (311 aa) FASTA scores: opt: 569, E(): 4.3e-24, (40.05% identity in 292 aa overlap); P95648|CBBX_RHOSH CBBX PROTEIN from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (309 aa), FASTA scores: opt: 559, E(): 1.5e-23, (41.4% identity in 290 aa overlap); etc. Equivalent to O33089|Y2G8_MYCLE|ML0055|MLCB628.18c HYPOTHETICAL 62.3 KDA PROTEIN from Mycobacterium leprae (573 aa), FASTA scores: opt: 3330, E(): 3.9e-175, (89.2% identity in 573 aa overlap); and similar to Q9CD28|Y282_MYCLE|ML2537 HYPOTHETICAL 69.1 KDA PROTEIN from Mycobacterium leprae (640 aa), FASTA scores: opt: 943, E(): 2.4e-44, (37.5% identity in 571 aa overlap). Also similar to many proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 936, E(): 5.8e-44, (39.05% identity in 568 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7TVG8 No cell wall and cell processes Rv3868 NC_002945.3 Mycobrowser_v2 CDS 4281359 4282801 . + 0 Mb3899 eccb1 esx conserved component eccb1. esx-1 type vii secretion system protein. possible membrane protein. Mb3899, -, len: 480 aa. Equivalent to Rv3869, len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Possible conserved membrane protein (has hydrophobic stretch near N-terminus), equivalent to O33088|ML0054|MLCB628.17c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (481 aa), FASTA scores: opt: 2489, E(): 8.3e-136, (75.75% identity in 478 aa overlap); and similar to others e.g. Q9Z5I3|ML1544|MLCB596.27 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (506 aa), FASTA scores: opt: 739,E(): 3.9e-35, (33.65% identity in 490 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. O05449|Rv3895c|MTCY15F10.17 (495 aa),FASTA scores: opt: 795, E(): 2.3e-38, (35.8% identity in 486 aa overlap); O53933|Rv1782|MTV049.04 (506 aa), FASTA scores: opt: 763, E(): 1.6e-36, (34.7% identity in 490 aa overlap); O06317|Rv3450c|MTCY13E12.03c (470 aa) FASTA scores: opt: 717, E(): 6.7e-34, (32.55% identity in 479 aa overlap); etc. Q7TVG7 No cell wall and cell processes Rv3869 NC_002945.3 Mycobrowser_v2 CDS 4285147 4286922 . + 0 Mb3901 ecccb1 esx conserved component ecccb1. esx-1 type vii secretion system protein. Mb3901, -, len: 591 aa. Equivalent to Rv3871, len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 591 aa overlap). Conserved hypothetical protein, equivalent to Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa) FASTA scores: opt: 3341, E(): 9.8e-192, (80.85% identity in 596 aa overlap); and O33086|MLCB628.15c HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 3329, E(): 5.1e-191, (80.55% identity in 596 aa overlap). And similar to C-terminal end of others e.g. Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 601, E(): 5.6e-28, (32.3% identity in 613 aa overlap); O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 977,E(): 2.1e-50, (35.15% identity in 583 aa overlap); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 414, E(): 9e-17, (27.6% identity in 424 aa overlap);P71068|YUKA YUKA PROTEIN from Bacillus subtilis (1207 aa), FASTA scores: opt: 343, E(): 1.3e-12, (25.8% identity in 395 aa overlap); etc. And similar to to C-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O06264|Rv3447c|MTCY77.19c (1236 aa) FASTA scores: opt: 845, E(): 1.5e-42, (35.3% identity in 586 aa overlap); O53689|Rv0284|MTV035.12 (1330 aa) FASTA scores: opt: 646, E(): 1.2e-30, (33.35% identity in 606 aa overlap); O53935|Rv1784|MTV049.06 (932 aa) FASTA scores: opt: 589, E(): 2.1e-27, (33.1% identity in 619 aa overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in upstream ORF MTV027.05. Q7TVG5 No cell wall and cell processes Rv3871 NC_002945.3 Mycobrowser_v2 CDS 4287065 4287361 . + 0 Mb3902 PE35 pe family-related protein pe35 Mb3902, PE35, len: 98 aa. Equivalent to Rv3872,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Some similarity to Mycobacterium tuberculosis conserved PE family proteins,e.g. O69713|Rv3746c|MTV025.094c (111 aa), FASTA scores: opt: 306, E(): 5.5e-13, (50.5% identity in 99 aa overlap). Equivalent to AAK48354 from Mycobacterium tuberculosis strain CDC1551 (112 aa) but shorter 14 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (g-t) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (98 aa versus 99 aa). Q7TVG4 No PE/PPE Rv3872 NC_002945.3 Mycobrowser_v2 CDS 4296564 4296911 . - 0 Mb3910c espl esx-1 secretion-associated protein espl Mb3910c, -, len: 115 aa. Equivalent to Rv3880c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Conserved hypothetical protein, equivalent to O33080|ML0044|MLCB628.09 HYPOTHETICAL 12.2 KDA PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 397, E(): 2e-19, (56.35% identity in 110 aa overlap). Q7TVF8 No cell wall and cell processes Rv3880c