Refseq_ID Mycobrowser_Version Feature Start Stop Score Strand Frame Locus Name Function Product Comments UniProt_AC Is_Pseudogene Functional_Category Orthologues M. leprae Orthologues M. marinum Orthologues M. smegmatis Orthologues M. tuberculosis NC_002945.3 Mycobrowser_v2 CDS 4288594 4288896 . + 0 Mb3904 esxB 10 kda culture filtrate antigen esxb (lhp) (cfp10) Mb3904, esxB, len: 100 aa. Equivalent to Rv3874,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). esxB (alternate gene name: cfp10), 10 KDA culture filtrate antigen (see citations below, especially first), highly similar to O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA CULTURE FILTRATE ANTIGEN CFP10 HOMOLOG from Mycobacterium leprae (99 aa), FASTA scores: opt: 237, E(): 2.4e-08, (39.4% identity in 99 aa overlap). Also similar to O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 PUTATIVE ESAT-6 LIKE PROTEIN 13 from Mycobacterium tuberculosis (103 aa) FASTA scores: opt: 126, E(): 0.18, (23.1% identity in 91 aa overlap); and shows some similarity with other proteins from Mycobacterium tuberculosis. Contains probable coiled-coil from aa 49-93. BELONGS TO THE ESAT6 FAMILY. X2BQ42,P0A567 No cell wall and cell processes Rv3874 NC_002945.3 Mycobrowser_v2 CDS 4296908 4298290 . - 0 Mb3911c espb secreted esx-1 substrate protein b, espb. conserved alanine and glycine rich protein Mb3911c, -, len: 460 aa. Equivalent to Rv3881c,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 460 aa overlap). Conserved hypothetical ala-, gly-rich protein. C-terminal end highly similar to O06126 HYPOTHETICAL 9.5 KDA PROTEIN (FRAGMENT) from Mycobacterium tuberculosis strain NTI 64719 (90 aa) FASTA scores: opt: 333, E(): 6.3e-07, (69.75% identity in 86 aa overlap) but sequence difference causes frameshift in NTI 64719. Also similar to part of small Mycobacterium leprae ORF O33078|MLCB628.06 (EMBL:Y14967) (101 aa), FASTA scores: opt: 194, E(): 0.04, (59.3% identity in 54 aa overlap), suggesting this is represented by a pseudogene in M. leprae. Q7TVB3 No cell wall and cell processes Rv3881c NC_002945.3 Mycobrowser_v2 CDS 4288929 4289216 . + 0 Mb3905 esxA 6 kda early secretory antigenic target esxa (esat-6) Mb3905, esxA, len: 95 aa. Equivalent to Rv3875,len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 95 aa overlap). esxA, Early Secretory Antigenic Target (see citations below), identical to Q57165|O84901|ESAT6 EARLY SECRETORY ANTIGENIC TARGET from Mycobacterium bovis (94 aa), FASTA scores: opt: 596, E(): 4.6e-33, (100.0% identity in 94 aa overlap). Also similar to Q50206|ESA6_MYCLE|ESAT6|ESX|L45|ML0049|MLCB628.12c 6 KDA EARLY SECRETORY ANTIGENIC TARGET HOMOLOG (ESAT-6-LIKE PROTEIN) (L-ESAT) from Mycobacterium leprae (95 aa), FASTA scores: opt: 236, E(): 3.3e-09, (36.25% identity in 91 aa overlap); and weak similarity with others proteins ESAT-like from Mycobacterium leprae. Also some similarity with O53266|ES69_MYCTU|Rv3019c|MT3104|MTV012.33c PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 131, E(): 0.03,(26.15% identity in 88 aa overlap); and other ESAT-like protein. Contains probable coiled-coil from 56 to 92 aa. BELONGS TO THE ESAT6 FAMILY. X2BPJ5,P0A565 No cell wall and cell processes Rv3875 NC_002945.3 Mycobrowser_v2 CDS 4289330 4291330 . + 0 Mb3906 espi esx-1 secretion-associated protein espi. conserved proline and alanine rich protein. Mb3906, -, len: 666 aa. Equivalent to Rv3876, len: 666 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 666 aa overlap). Conserved hypothetical pro-, ala-rich protein, similar to several proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 HYPOTHETICAL PROTEIN (586 aa), FASTA scores: opt: 1682,E(): 2.1e-45, (50.75% identity in 672 aa overlap); O33082|MLCB628.11c HYPOTHETICAL 52.0 KDA PROTEIN (478 aa),FASTA scores: opt: 1588, E(): 1.5e-42, (53.5% identity in 542 aa overlap) (also has a proline rich N-terminus); etc. Also similar to other proteins from Mycobacterium tuberculosis, especially in C-terminus, e.g. O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 670, E(): 2.5e-14, (34.85% identity in 396 aa overlap) (also has Pro-rich N-terminus); etc. Note that N-terminus is repetitive and highly Proline rich. Q7TVG2 No cell wall and cell processes Rv3876 NC_002945.3 Mycobrowser_v2 CDS 4301344 4303203 . - 0 Mb3914c ecca2 esx conserved component ecca2. esx-2 type vii secretion system protein. probable cbxx/cfqx family protein. Mb3914c, -, len: 619 aa. Equivalent to Rv3884c,len: 619 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 619 aa overlap). Putative CBXX/CFQX protein family, similar to hypothetical proteins from Mycobacterium leprae e.g. Q9CD28|Y282_MYCLE|ML2537 (640 aa), FASTA scores: opt: 725, E(): 2.9e-34, (28.95% identity in 587 aa overlap); O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (BELONGS TO THE CBXX/CFQX FAMILY) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa overlap). Also similar to proteins belonging to the CBXX/CFQX FAMILY e.g. Q9RKZ2|SC6D7.05c PUTATIVE CBXX/CFQX FAMILY PROTEIN from Streptomyces coelicolor (618 aa) FASTA scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ STAGE V SPORULATION PROTEIN K from Bacillus subtilis (322 aa) FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in 280 aa overlap) (similarity only at C-terminus); Q9KAC6|BH2363 STAGE V SPORULATION PROTEIN K from Bacillus halodurans (315 aa), FASTA scores: opt: 462, E(): 2.2e-19,(36.05% identity in 244 aa overlap) (similarity only at C-terminus); etc. And similar to hypothetical proteins from Mycobacterium tuberculosis belonging to the CBXX/CFQX FAMILY e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 743, E(): 2.6e-35, (29.9% identity in 612 aa overlap); O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 HYPOTHETICAL 62.4 KDA PROTEIN (573 aa), FASTA scores: opt: 678, E(): 1.3e-31, (31.25% identity in 589 aa overlap); O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SEEMS TO BELONG TO THE CBXX/CFQX FAMILY. X2BQ44,P59976 No cell wall and cell processes Rv3884c NC_002945.3 Mycobrowser_v2 CDS 4291327 4292862 . + 0 Mb3907 eccd1 esx conserved component eccd1. esx-1 type vii secretion system protein. probable transmembrane protein. Mb3907, -, len: 511 aa. Equivalent to Rv3877, len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CDD9|ML0047 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (512 aa), FASTA scores: opt: 2496, E(): 2.8e-140, (74.0% identity in 512 aa overlap); and highly similar, but longer 32 aa, to O33081|MLCB628.10c HYPOTHETICAL 51.4 KDA PROTEIN from Mycobacterium leprae (480 aa), FASTA scores: opt: 2346, E(): 2e-131, (74.15% identity in 480 aa overlap). Shows also similarity with other membrane proteins from Mycobacterium leprae e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 318, E(): 2e-11, (22.7% identity in 520 aa overlap). Also similar to various proteins from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 391, E(): 9.4e-16, (24.45% identity in 523 aa overlap); O86362|Rv0290|MTV035.18 HYPOTHETICAL 47.9 KDA PROTEIN (472 aa), FASTA scores: opt: 332, E(): 2.8e-12, (28.1% identity in 509 aa overlap); O05457|Rv3887c|MTCY15F10.25 HYPOTHETICAL 53.2 KDA PROTEIN (509 aa), FASTA scores: opt: 167, E(): 0.017, (24.0% identity in 517 aa overlap); etc. Equivalent to AAK48359 from Mycobacterium tuberculosis strain CDC1551 (479 aa) but longer 32 aa. Q7TVG1 No cell wall and cell processes Rv3877 NC_002945.3 Mycobrowser_v2 CDS 4293013 4293855 . + 0 Mb3908 espj esx-1 secretion-associated protein espj. conserved alanine rich protein. Mb3908, -, len: 280 aa. Equivalent to Rv3878, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 280 aa overlap). Hypothetical unknown ala-rich protein. Q7TVG0 No cell wall and cell processes Rv3878 NC_002945.3 Mycobrowser_v2 CDS 4293913 4296147 . - 0 Mb3909c espk esx-1 secretion-associated protein espk. alanine and proline rich protein. Mb3909c, -, len: 744 aa. Equivalent to Rv3879c,len: 729 aa, from Mycobacterium tuberculosis strain H37Rv,(98.0% identity in 743 aa overlap). Hypothetical unknown ala-, pro-rich protein (N-terminal end is repetitive and highly Proline-rich). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 27 bp and 18 bp lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (744 aa versus 729 aa). Q7TVF9 No cell wall and cell processes Rv3879c NC_002945.3 Mycobrowser_v2 CDS 4298397 4299785 . - 0 Mb3912c ecce1 esx conserved component ecce1. esx-1 type vii secretion system protein. possible membrane protein. Mb3912c, -, len: 462 aa. Equivalent to Rv3882c,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Possible conserved membrane protein, equivalent to O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 2346, E(): 1.1e-140, (72.1% identity in 462 aa overlap). Also similar to O05459|Rv3885c|MTCY15F10.27 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (537 aa) FASTA scores: opt: 283, E(): 2.5e-10, (26.8% identity in 414 aa overlap); and C-terminal end shows similarity with AAK48368|MT4000 HYPOTHETICAL 45.6 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (422 aa) FASTA scores: opt: 215, E(): 4.1e-06, (26.85% identity in 320 aa overlap). Q7TVF7 No cell wall and cell processes Rv3882c NC_002945.3 Mycobrowser_v2 CDS 4299782 4301122 . - 0 Mb3913c mycp1 membrane-anchored mycosin mycp1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1) Mb3913c, -, len: 446 aa. Equivalent to Rv3883c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 446 aa overlap). Possible secreted protease (EC 3.4.-.-), equivalent to O33076|ML0041|MLCB628.04 PROBABLE SECRETED PROTEASE from Mycobacterium leprae (446 aa), FASTA scores: opt: 2448,E(): 1.5e-124, (79.15% identity in 446 aa overlap); and highly similar, but in part, to several putative proteases from Mycobacterium leprae; Q9CBV3|ML1538 (567 aa) FASTA scores: opt: 902, E(): 3e-41, (37.25% identity in 556 aa overlap); and Q9CD36|ML2528 (475 aa), FASTA scores: opt: 873, E(): 9.4e-40, (42.7% identity in 459 aa overlap). Shows also similarity with several proteases from other organisms e.g. Q9PCD0|XF1851 SERINE PROTEASE from Xylella fastidiosa (1000 aa), FASTA scores: opt: 281, E(): 1.3e-07, (27.95% identity in 422 aa overlap); P42780|BPRX_BACNO EXTRACELLULAR SUBTILISIN-LIKE PROTEASE PRECURSOR (EC 3.4.21.-) from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 270,E(): 3.2e-07, (28.9% identity in 384 aa overlap); Q46541|APRV5 ACIDIC PROTEASE V5 from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 264,E(): 6.8e-07, (28.65% identity in 384 aa overlap); etc. Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53695|Rv0291|MTV035.19 PUTATIVE PROTEASE (461 aa), FASTA scores: opt: 1168, E(): 1.2e-55,(44.6% identity in 453 aa overlap); O53945|Rv1796|MTV049.18 HYPOTHETICAL 60.0 KDA PROTEIN (585 aa), FASTA scores: opt: 928, E(): 1.2e-42, (37.85% identity in 555 aa overlap) (note gap from aa 155-264); and downstream ORF O05458|Rv3886c|MTCY15F10.26 HYPOTHETICAL 55.6 KDA PROTEIN (550 aa), FASTA scores: opt: 910, E(): 1.1e-41, (40.15% identity in 533 aa overlap) (note partial gap from aa 146-234); etc. Equivalent to AAK48366 from Mycobacterium tuberculosis strain CDC1551 (411 aa) but longer 35 aa. Has signal sequence with possible signal peptidase I cleavage site in residues 19-21 (ASA) and hydrophobic stretch at C-terminus,followed by short positively charged segment, that could act as membrane anchor. Q7TVF6 No intermediary metabolism and respiration Rv3883c NC_002945.3 Mycobrowser_v2 CDS 4303273 4304886 . - 0 Mb3915c ecce2 esx conserved component ecce2. esx-2 type vii secretion system protein. possible membrane protein. Mb3915c, -, len: 537 aa. Equivalent to Rv3885c,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 537 aa overlap). Possible conserved membrane protein (has hydrophobic stretch near N-terminus), showing some similarity with O05462|Rv3882c|MTV027.17c|MTCY15F10.30 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (462 aa) FASTA scores: opt: 283, E(): 8.3e-10, (26.55% identity in 414 aa overlap); and O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 260, E(): 2.1e-08, (28.0% identity in 382 aa overlap). Equivalent to AAK48368 from Mycobacterium tuberculosis strain CDC1551 (422 aa) but longer 115 aa. Q7TVF5 No cell wall and cell processes Rv3885c NC_002945.3 Mycobrowser_v2 CDS 4310219 4311904 . - 0 Mb3923c eccc2 POSSIBLE CONSERVED MEMBRANE PROTEIN [SECOND PART] Mb3923c, -, len: 561 aa. Equivalent to 3' end of Rv3894c, len: 1396 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 561 aa overlap). Possible conserved membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 652, E(): 2.2e-30,(27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa),FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 523, E(): 8.6e-23, (31.65% identity in 1412 aa overlap). Also similar to various proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 973, E(): 2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23,(24.95% identity in 1450 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),FASTA scores: opt: 444, E(): 4.1e-18, (22.5% identity in 1346 aa overlap); etc. Also similar to AAK46103|MT1833 FTSK/SPOIIIE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt: 769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap); and other hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391 aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa overlap) (similarity only with C-terminal end); etc. Contains two possible (PS00017) ATP/GTP-binding sites (P-loop) in central portion. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts, Mb3923c and Mb3924c. Q7TVE7 No NC_002945.3 Mycobrowser_v2 CDS 4324398 4324670 . - 0 Mb3934c esxE putative esat-6 like protein esxe (hypothetical alanine rich protein) (esat-6 like protein 12) Mb3934c, esxE, len: 90 aa. Equivalent to Rv3904c,len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 90 aa overlap). esxE, putative ESAT-6 like protein 12, hypothetical unknown ala-rich protein. BELONGS TO THE ESAT6 FAMILY. Q7TVD7 No NC_002945.3 Mycobrowser_v2 CDS 4304883 4306535 . - 0 Mb3916c mycp2 probable alanine and proline rich membrane-anchored mycosin mycp2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2) Mb3916c, -, len: 550 aa. Equivalent to Rv3886c,len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 550 aa overlap). Probable ala-,pro-rich protease (EC 3.4.-.-), highly similar to Q9CBV3|ML1538 POSSIBLE PROTEASE from Mycobacterium leprae (567 aa), FASTA scores: opt: 1034, E(): 3.9e-32, (43.5% identity in 575 aa overlap); and highly similar, but with gaps, to several putative proteases from Mycobacterium leprae; O33076|ML0041|MLCB628.04 (446 aa), FASTA scores: opt: 860, E(): 1.1e-25, (38.65% identity in 538 aa overlap); Q9CD36|ML2528 (475 aa) (475 aa), FASTA scores: opt: 413, E(): 7.1e-09, (37.7% identity in 562 aa overlap). Also similarity with Q99405|PRTM_BACSP M-PROTEASE (EC 3.4.21.-) from Bacillus sp. strain KSM-K16 (269 aa), FASTA scores: E(): 7.6e-06, (27.1% identity in 277 aa overlap). And highly similar, but also with gaps,to hypothetical proteins from Mycobacterium tuberculosis e.g. O53945|Rv1796|MTV049.18 (585 aa), FASTA scores: opt: 1173, E(): 2.4e-37, (47.9% identity in 578 aa overlap); the upstream ORF O05461|Rv3883c|MTCY15F10.29 (446 aa) FASTA scores: opt: 910, E(): 1.5e-27, (40.15% identity in 533 aa overlap); O06316|Rv3449|MTCY13E12.02 (455 aa) FASTA scores: opt: 477, E(): 2.7e-11, (38.75% identity in 550 aa overlap); etc. Pro rich protein with two serine protease,subtilase family active site motifs: aspartic acid active site motif (PS00136); and histidine active site motif (PS00137). BELONGS TO PEPTIDASE FAMILY S8; ALSO KNOWN AS THE SUBTILASE FAMILY. Q7TVF4 No intermediary metabolism and respiration Rv3886c NC_002945.3 Mycobrowser_v2 CDS 4306520 4307389 . - 0 Mb3917c eccd2 esx conserved component eccd2. esx-2 type vii secretion system protein. probable transmembrane protein. Mb3917c, -, len: 289 aa. Equivalent to 3' end of Rv3887c, len: 509 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 288 aa overlap). Probable conserved transmembrane protein (has hydrophilic stretch from ~1-130 then very hydrophobic domain), similar to other membrane proteins and with weak similarity to known transporters, e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN from Mycobacterium leprae (503 aa), FASTA scores: opt: 395, E(): 2.3e-16, (28.0% identity in 496 aa overlap); Q9CD35|ML2529 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (485 aa), FASTA scores: opt: 221,E(): 6.6e-06, (24.6% identity in 423 aa overlap); Q9ADP8|2SC10A7.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (430 aa), FASTA scores: opt: 171,E(): 0.0062, (26.55% identity in 358 aa overlap); CAC44275|SCBAC17F8.03 PUTATIVE DRUG EFFLUX PROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 160,E(): 0.028, (27.85% identity in 323 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 360, E(): 2.9e-14, (26.65% identity in 514 aa overlap); etc. Equivalent to AAK48369 from Mycobacterium tuberculosis strain CDC1551 (469 aa) but longer 40 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 2406 bp leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv. Q7TVF3 No NC_002945.3 Mycobrowser_v2 CDS 4307371 4307589 . - 0 Mb3918c espg2 esx-2 secretion-associated protein espg2 Mb3918c, -, len: 72 aa. Equivalent to 5' end of Rv3889c, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 68 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv. Q7TVF2 No NC_002945.3 Mycobrowser_v2 CDS 4307597 4307971 . - 0 Mb3919c esxC esat-6 like protein esxc (esat-6 like protein 11) Mb3919c, esxC, len: 124 aa. Similar to Rv3890c,len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 55 aa overlap). esxC, putative ESAT-6 like protein 11, equivalent to Q9K548|ES6B_MYCPA PUTATIVE ESAT-6 LIKE PROTEIN 11 (ORF3890C) from Mycobacterium paratuberculo sis (95 aa), FASTA scores: opt: 490, E(): 3.3e-26, (76.85% identity in 95 aa overlap). BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (125 aa versus 95 aa). Q7TVF1 No NC_002945.3 Mycobrowser_v2 CDS 4308007 4308330 . - 0 Mb3920c esxD possible esat-6 like protein esxd Mb3920c, esxD, len: 107 aa. Equivalent to Rv3891c,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 107 aa overlap). esxD, conserved hypothetical protein, equivalent to Q9K547 HYPOTHETICAL 10.3 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (100 aa), FASTA scores: opt: 498, E(): 1.7e-26, (77.25% identity in 101 aa overlap). Q7TVF0 No NC_002945.3 Mycobrowser_v2 CDS 4308441 4309640 . - 0 Mb3921c PPE69 ppe family protein ppe69 Mb3921c, PPE69, len: 399 aa. Equivalent to Rv3892c,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 399 aa overlap). Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348, E(): 2.2e-08, (26.6% identity in 380 aa overlap). Q7TVE9 No NC_002945.3 Mycobrowser_v2 CDS 4309719 4309952 . - 0 Mb3922c PE36 pe family protein pe36 Mb3922c, PE36, len: 77 aa. Equivalent to Rv3893c,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Member of the Mycobacterium tuberculosis PE family of conserved proteins, similar to other e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). Q7TVE8 No NC_002945.3 Mycobrowser_v2 CDS 4314411 4315898 . - 0 Mb3925c eccb2 esx conserved component eccb2. esx-2 type vii secretion system protein. probable membrane protein. Mb3925c, -, len: 495 aa. Equivalent to Rv3895c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Possible conserved membrane protein, highly similar to two CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae: Q9Z5I3|ML1544|MLCB596.27 (506 aa), FASTA scores: opt: 1070, E(): 1.4e-53, (39.8% identity in 485 aa overlap); and Q9CD29|ML2536 (552 aa), FASTA scores: opt: 483, E(): 4e-20, (36.85% identity in 499 aa overlap). Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53933|Rv1782|MTV049.04 HYPOTHETICAL PROTEIN (506 aa), FASTA scores: opt: 1106, E(): 1.2e-55,(41.25% identity in 485 aa overlap); O69734|Rv3869|MTV027.04 HYPOTHETICAL PROTEIN (480 aa),FASTA scores: opt: 795, E(): 6.1e-38, (36.0% identity in 486 aa overlap); O33088|ML0054|MLCB628.17c PUTATIVE MEMBRANE PROTEIN) (481 aa), FASTA scores: opt: 740, E(): 8.3e-35, (35.65% identity in 485 aa overlap); etc. Q7TVE5 No cell wall and cell processes Rv3895c NC_002945.3 Mycobrowser_v2 CDS 4315942 4316808 . - 0 Mb3926c CONSERVED HYPOTHETICAL PROTEIN Mb3926c, -, len: 288 aa. Similar to Rv3896c, len: 302 aa (first GTG taken, although TBparse suggests TTG at 16079), from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 249 aa overlap). Putative conserved ala-rich protein. C-terminus highly similar to C-terminal end of other proteins e.g. Q9XAS4|SC10A7.01 HYPOTHETICAL 17.2 KDA PROTEIN from Streptomyces coelicolor (244 aa),FASTA scores: opt: 255, E(): 1.4e-08, (32.0% identity in 222 aa overlap); CAC44611|STBAC16H6.32 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (172 aa), FASTA scores: opt: 214, E(): 3.4e-06, (42.55% identity in 94 aa overlap); Q38352|ORF360 from Lactococcus delbrueckii bacteriophage LL-H (360 aa), FASTA scores: opt: 211, E(): 9.5e-06, (40.0% identity in 115 aa overlap); P54334|XKDO_BACSU|XKDO PHAGE-LIKE ELEMENT PBSX PROTEIN from Bacillus subtilis (1332 aa), FASTA scores: opt: 209,E(): 3.6e-05, (38.35% identity in 86 aa overlap); etc. Also similar to P71594|P71594|Rv0024|MTCY10H4.24 HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium tuberculosis (281 aa), FASTA scores: opt: 265, E(): 3.9e-09, (29.25% identity in 287 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a product with a different COOH part than in Mycobacterium tuberculosis (288 aa versus 302 aa). Q7TVE4 No NC_002945.3 Mycobrowser_v2 CDS 4316958 4317947 . - 0 Mb3927c CONSERVED HYPOTHETICAL PROTEIN Mb3927c, -, len: 329 aa. Equivalent to Rv3898c and Rv3897c, len: 110 aa and 210 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 110 aa overlap and 98.8% identity in 168 aa overlap). Conserved hypothetical proteins. Highly similar, but in part, to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 HYPOTHETICAL 30.8 KDA PROTEIN from Mycobacterium tuberculosis (314 aa) FASTA scores: opt: 204, E(): 0.00042, (50.6% identity in 81 aa overlap) and FASTA scores: opt: 815, E(): 4.7e-26,(73.05% identity in 167 aa overlap). Similarity suggests it should be in frame with next ORF and that the stop codon could be read through, the sequence appears to be correct. Homology lost upstream at 15138 gatc sequence may suggest discontinuity due to chimerism in cY15F10 or cY49. Similarity to MTCY49.22 suggests that this is a continuation of MTCY15F10.14. There is a frameshift mutation near 3'-end with respect to this sequence as well, similarity to MTCY49.22 continues in an overlapping ORF. Sequence appears to be correct. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis, a single base transition (t-c) leads to a single product. Q7TVE3 No conserved hypotheticals Rv3898c NC_002945.3 Mycobrowser_v2 CDS 4324819 4324992 . - 0 Mb3935c esxF putative esat-6 like protein esxf (hypothetical alanine and glycine rich protein) (esat-6 like protein 13) Mb3935c, esxF, len: 57 aa. Equivalent to Rv3905c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). esxF, putative ESAT-6 like protein 13, hypothetical unknown ala-, gly-rich protein, ESAT-6 like protein. BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (g-a) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa). Q7TVD6 No NC_002945.3 Mycobrowser_v2 CDS 4318109 4318990 . - 0 Mb3928c CONSERVED HYPOTHETICAL PROTEIN Mb3928c, -, len: 293 aa. Equivalent to 3' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 293 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product. Q7TVE2 No NC_002945.3 Mycobrowser_v2 CDS 4318597 4319340 . - 0 Mb3929c CONSERVED HYPOTHETICAL PROTEIN Mb3929c, -, len: 247 aa. Equivalent to 5' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (90.8% identity in 130 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. In Mycobacterium tuberculosis strain H37Rv,Rv3899c (len: 410 aa) exists as a single gene on a single reading frame. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product. No NC_002945.3 Mycobrowser_v2 CDS 4319334 4320269 . - 0 Mb3930c CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN Mb3930c, -, len: 311 aa. Equivalent to Rv3900c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 311 aa overlap). Conserved hypothetical ala-rich protein, highly similar to N-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN from Mycobacterium tuberculosis (721 aa), FASTA scores: opt: 592, E(): 2.7e-22, (37.15% identity in 280 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. Q7TVE1 No conserved hypotheticals Rv3900c NC_002945.3 Mycobrowser_v2 CDS 4321853 4324393 . - 0 Mb3933c HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN Mb3933c, -, len: 846 aa. Equivalent to Rv3903c,len: 846 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 846 aa overlap). Hypothetical unknown ala-, pro-rich protein. Q7TVD8 No conserved hypotheticals Rv3903c NC_002945.3 Mycobrowser_v2 CDS 4325058 4325567 . - 0 Mb3936c CONSERVED HYPOTHETICAL PROTEIN Mb3936c, -, len: 169 aa. Equivalent to Rv3906c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Conserved hypothetical protein, strongly related to Q50578|AT9S (SOD related in Escherichia coli) from Mycobacterium tuberculosis strain AOYAMA B (155 aa), but apparently different as flanking sequences differ and shorter 43 aa,FASTA scores: opt: 548, E(): 1.3e-26, (79.4% identity in 102 aa overlap). Selfmarch results suggest that Rv3906c is not related to any other hypothetical protein from M. tuberculosis strain H37Rv except itself. Shows also similarity with Q9VFR2|CG9297 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (930 aa), FASTA scores: opt: 221, E(): 4.9e-06, (36.95% identity in 157 aa overlap); Q9HQ55|CBP|VNG1320G CALCIUM-BINDING PROTEIN HOMOLOGY from Halobacterium sp. strain NRC-1 (385 aa) FASTA scores: opt: 143, E(): 0.13, (35.65% identity in 160 aa overlap); Q24795 CALCIUM-BINDING PROTEIN (FRAGMENT) from Echinococcus granulosus (338 aa), FASTA scores: opt: 140, E(): 0.17, (33.95% identity in 156 aa overlap). Q7TVD5 No conserved hypotheticals Rv3906c NC_002945.3 Mycobrowser_v2 CDS 4325592 4327034 . - 0 Mb3937c pcnA probable poly(a) polymerase pcna (polynucleotide adenylyltransferase) (ntp polymerase) (rna adenylating enzyme) (poly(a) polymerase) Mb3937c, pcnA, len: 480 aa. Equivalent to Rv3907c,len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Probable pcnA,polynucleotide polymerase (EC 2.7.7.19), equivalent to Q9CCY1|PCNA|ML2697 PCNA PROTEIN from Mycobacterium leprae (486 aa), FASTA scores: opt: 2713, E(): 4.3e-160, (84.1% identity in 478 aa overlap); and Q59534|PCNB POLYA POLYMERASE from Mycobacterium leprae (411 aa) FASTA scores: opt: 2077, E(): 7.1e-121, (82.55% identity in 373 aa overlap). Also highly similar to many e.g. Q9X8T2|SCH24.18 PUTATIVE RNA NUCLEOTIDYLTRANSFERASE from Streptomyces coelicolor (483 aa), FASTA scores: opt: 1856,E(): 3.7e-107, (61.55% identity in 455 aa overlap); Q9ZN65 POLYA POLYMERASE from Prevotella ruminicola (Bacteroides ruminicola) (479 aa), FASTA scores: opt: 830, E(): 8.5e-44, (34.85% identity in 445 aa overlap); P42977|PAPS_BACSU POLY(A) POLYMERASE from Bacillus subtilis (397 aa), FASTA scores: opt: 479, E(): 3.5e-22,(29.35% identity in 450 aa overlap); etc. Contains: PS00017 ATP/GTP-binding site motif A (P-loop), PS00018 EF-hand calcium-binding domain, and probably less significant a PS00237 G-protein coupled receptor signature, and PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. BELONGS TO THE TRNA NUCLEOTIDYLTRANSFERASE / POLY(A) POLYMERASE FAMILY. Q7TVD4 No NC_002945.3 Mycobrowser_v2 CDS 4327410 4328156 . + 0 Mb3938 mutt4 possible mutator protein mutt4 Mb3938, -, len: 248 aa. Equivalent to Rv3908, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Conserved hypothetical protein, equivalent to Q50195|ML2698|L222-ORF6 HYPOTHETICAL PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 1270,E(): 3.4e-62, (79.05% identity in 248 aa overlap). Also similar to O66548|APFA|AQ_158 HYDROLASE from Aquifex aeolicus (134 aa), FASTA scores: opt: 300, E(): 1.1e-09,(37.3% identity in 142 aa overlap); and similarity with other various proteins e.g. O93721 DIADENOSINE 5'5'''-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Pyrobaculum aerophilum (143 aa), FASTA scores: opt: 205,E(): 0.00017, (34.85% identity in 109 aa overlap); Q9HS29|APA|VNG0431G DIADENOSINE TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Halobacterium sp. strain NRC-1 (142 aa), FASTA scores: opt: 199, E(): 0.00036, (34.0% identity in 147 aa overlap); Q9YA58|APE2080 HYPOTHETICAL 19.2 KDA PROTEIN from Aeropyrum pernix (175 aa) FASTA scores: opt: 191, E(): 0.0012, (36.9% identity in 141 aa overlap); etc. Also similar to P95110|MUTT1|Rv2985|MTCY349.02 HYPOTHETICAL 34.7 KDA PROTEIN from Mycobacterium tuberculosis (317 aa) FASTA scores: opt: 224, E(): 3e-05, (34.05% identity in 144 aa overlap). Q7TVD3 No information pathways Rv3908 NC_002945.3 Mycobrowser_v2 CDS 4328153 4330561 . + 0 Mb3939 conserved protein Mb3939, -, len: 802 aa. Equivalent to Rv3909, len: 802 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 802 aa overlap). Conserved hypothetical protein, equivalent to Q9CCY0|ML2699 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (797 aa) FASTA scores: opt: 3777, E(): 8.8e-206, (72.35% identity in 803 aa overlap). Note that the N-terminal end is highly similar to Q50196|L222-ORF7 (286 aa), FASTA scores: opt: 1213,E(): 2.7e-61, (71.75% identity in 255 aa overlap); and the C-terminal end is highly similar to Q50197|L222-ORF8 also from Mycobacterium leprae (512 aa) FASTA scores: opt: 2375, E(): 9.9e-127, (71.8% identity in 518 aa overlap). Shows some similarity with N-terminal end of Q9I2M3|PA1874 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (2468 aa), FASTA scores: opt: 171, E(): 0.13, (22.9% identity in 672 aa overlap). Q7TVD2 No conserved hypotheticals Rv3909 NC_002945.3 Mycobrowser_v2 CDS 4334147 4334737 . + 0 Mb3941 sigMa POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMa [FIRST PART] Mb3941, sigMa, len: 196 aa. Similar to Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(95.8% identity in 168 aa overlap). Possible sigM,alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) PUTATIVE RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa),FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb. Q7TVD0 No NC_002945.3 Mycobrowser_v2 CDS 4334626 4334814 . + 0 Mb3942 sigMb POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMb [SECOND PART] Mb3942, sigMb, len: 62 aa. Equivalent to 3' end of Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Possible sigM, alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) PUTATIVE RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa), FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb. No NC_002945.3 Mycobrowser_v2 CDS 4335688 4336695 . + 0 Mb3944 trxB2 PROBABLE THIOREDOXIN REDUCTASE TRXB2 (TRXR) (TR) Mb3944, trxB2, len: 335 aa. Equivalent to Rv3913,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 335 aa overlap). Probable trxB2,thioredoxin reductase (EC 1.6.4.5) (see citation below),equivalent to O30973|TRXB_MYCSM THIOREDOXIN REDUCTASE from Mycobacterium smegmatis (311 aa), FASTA scores: opt: 1575,E(): 1.8e-87, (78.35% identity in 305 aa overlap); and highly similar, but shorter at C-terminus, to P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 1766, E(): 8.7e-99,(83.25% identity in 328 aa overlap). Also highly similar to many e.g. P52215|TRXB_STRCO|SCH24.12 from Streptomyces coelicolor (321 aa), FASTA scores: opt: 1249, E(): 7.2e-68, (60.4% identity in 313 aa overlap); Q9Z8M4|TRXB_CHLPN from Chlamydia pneumoniae (Chlamydophila pneumoniae) (311 aa), FASTA scores: opt: 978, E(): 1.3e-51, (49.85% identity in 307 aa overlap); P09625|TRXB_ECOLI|B0888 from Escherichia coli strain K12 (320 aa), FASTA scores: opt: 948, E(): 8.6e-50, (49.2% identity in 309 aa overlap); etc. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-II. COFACTOR: FAD (BY SIMILARITY). Q7TVC8 No NC_002945.3 Mycobrowser_v2 CDS 4336692 4337042 . + 0 Mb3945 trxC THIOREDOXIN TRXC (TRX) (MPT46) Mb3945, trxC, len: 116 aa. Equivalent to Rv3914,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). trxC (alternate gene names: trx, trxA *), thioredoxin (EC 1.-.-.-) (see citations below), equivalent to O30974|THIO_MYCSM|TRXA THIOREDOXIN from Mycobacterium smegmatis (112 aa), FASTA scores: opt: 576, E(): 2.1e-32, (80.2% identity in 111 aa overlap); and also equivalent to C-terminal end of P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 628, E(): E(): 2e-35,(82.9% identity in 117 aa overlap). Also highly similar to many e.g. P80579|THIO_ALIAC from Alicyclobacillus acidocaldarius (Bacillus acidocaldarius) (105 aa), FASTA scores: opt: 411, E(): 3e-21, (57.15% identity in 105 aa overlap); P00275|THI1_CORNE from Corynebacterium nephridii (105 aa), FASTA scores: opt: 394, E(): 4.3e-20, (56.7% identity in 97 aa overlap); P00274|THIO_ECOLI|TRXA|TSNC|FIPA|B3781 from Escherichia coli and Salmonella typhimurium strain K12 and LT2 respectively (108 aa), FASTA scores: opt: 364, E(): 4.7e-18, (54.45% identity in 101 aa overlap); etc. Also similar to O53162|TRXB|Rv1471|MTV007.18 THIOREDOXIN from Mycobacterium tuberculosis (123 aa), FASTA scores: E(): 2.3e-15, (41.9% identity in 93 aa overlap). Contains PS00194 Thioredoxin family active site. BELONGS TO THE THIOREDOXIN FAMILY. The product of this CDS is supposed secreted. In this cas, this protein could exert its free radical scavenging activity inside macrophages. (*) Warning: note that Rv1470|MTV007.17 correspond also to trxA. X2BPP7,P0A617 No intermediary metabolism and respiration Rv3914 NC_002945.3 Mycobrowser_v2 CDS 4337152 4338372 . + 0 Mb3946 probable peptidoglycan hydrolase Mb3946, -, len: 406 aa. Equivalent to Rv3915, len: 406 aa, from Myobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable hydrolase (EC 3.-.-.-), equivalent to Q9CCX8|ML2704 PUTATIVE HYDROLASE from Mycobacterium leprae (406 aa) FASTA scores: opt: 2341, E(): 2.7e-138, (86.95% identity in 406 aa overlap); the N-terminal end is highly similar to Q59535 N-ACETYMURAMYL-L-ALANINE AMIDASE (EC 3.5.1.28) from Mycobacterium leprae (205 aa), FASTA scores: opt: 1046,E(): 5.7e-58, (84.85% identity in 185 aa overlap). Also similar to other hydrolases (especially amidases (EC 3.5.-.-)) e.g. C-terminal end of Q9K6R3|LYTC|BH3665 N-ACETYLMURAMOYL-L-ALANINE AMIDASE (MAJOR AUTOLYSIN) from Bacillus halodurans (588 aa), FASTA scores: opt: 363, E(): 4.3e-15, (33.15% identity in 356 aa overlap); Q9PKC7|TC0539 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE from Chlamydia muridarum (268 aa), FASTA scores: opt: 285,E(): 1.6e-10, (26.05% identity in 242 aa overlap) (RV3915 product appears longer 127 aa); Q9S596|PDCA PENICILLIN-RESISTANT DD-CARBOXYPEPTIDASE (EC 3.4.-.-) from Myxococcus xanthus (302 aa), FASTA scores: opt: 270, E(): 1.5e-09, (39.85% identity in 158 aa overlap); etc. Note that previously known as cwlM. Q7TVC7 No intermediary metabolism and respiration Rv3915 NC_002945.3 Mycobrowser_v2 CDS 4339417 4340451 . - 0 Mb3948c parB PROBABLE CHROMOSOME PARTITIONING PROTEIN PARB Mb3948c, parB, len: 344 aa. Equivalent to Rv3917c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable parB,chromosome partitioning protein, equivalent to Q50201|PARB_MYCLE|ML2706 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium leprae (333 aa), FASTA scores: opt: 1654, E(): 1.6e-88, (78.6% identity in 332 aa overlap). Also highly similar to to others e.g. Q9S6U1|STH24.09 PUTATIVE PARTITIONING OR SPORULATION PROTEIN from Streptomyces coelicolor (328 aa), FASTA scores: opt: 966, E(): 9.7e-49, (58.55% identity in 287 aa overlap) (no similarity on N-terminus); Q9PB63|PARB_XYLFA|XF2281 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Xylella fastidiosa (310 aa), FASTA scores: opt: 598, E(): 1.8e-27, (38.65% identity in 326 aa overlap); P31857|PARB_PSEPU PROBABLE CHROMOSOME PARTITIONING PROTEIN from Pseudomonas putida (290 aa),FASTA scores: opt: 573, E(): 4.6e-26, (40.35% identity in 322 aa overlap); etc. Contains probable helix-turn-helix motif at aa 179 to 200 (Score 1150, +3.1 0 SD). BELONGS TO THE PARB FAMILY. Note that previously known as parA. X2BQ08,P0A5R3 No NC_002945.3 Mycobrowser_v2 CDS 4340448 4341491 . - 0 Mb3949c parA PROBABLE CHROMOSOME PARTITIONING PROTEIN PARA Mb3949c, parA, len: 347 aa. Equivalent to Rv3918c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Probable parA,chromosome partitioning protein, highly similar to Q9CCX7|PARA|ML2707 PUTATIVE CELL DIVISION PROTEIN from Mycobacterium leprae (351 aa), FASTA scores: opt: 1679,E(): 2.9e-93, (78.1% identity in 347 aa overlap). Also highly similar to others e.g. Q9RFM1|PARA PARA PROTEIN from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1197, E(): 2e-64, (60.45% identity in 306 aa overlap); Q98DZ3|MLL4479|PARA CHROMOSOME PARTITIONING PROTEIN from Rhizobium loti (Mesorhizobium loti) (266 aa), FASTA scores: opt: 835, E(): 7.2e-43, (50.95% identity in 257 aa overlap); O05189|PARA_CAUCR CHROMOSOME PARTITIONING PROTEIN from Caulobacter crescentus (267 aa), FASTA scores: opt: 813, E(): 1.5e-41, (51.35% identity in 261 aa overlap) (has its N-terminus shorter); etc. Equivalent to AAK48403 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 34 aa. Also similar to other M. tuberculosis proteins: MTCI125.30, FASTA scores: E(): 4.3e-32, (35.2% identity in 327 aa overlap); and MTCY07D11.13, FASTA scores: E(): 3e-30, (39.9% identity in 263 aa overlap). BELONGS TO THE PARA FAMILY. Possible alternative start site at aa 107. Note that previously known as parB. Q7TVC5 No NC_002945.3 Mycobrowser_v2 CDS 4341488 4342162 . - 0 Mb3950c gid PROBABLE GLUCOSE-INHIBITED DIVISION PROTEIN B GID Mb3950c, gid, len: 224 aa. Equivalent to Rv3919c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Probable gid (alternate gene name: gidB), glucose-inhibited division protein B, equivalent, but shorter 20 aa, to Q9L7M3 PUTATIVE GIDB (FRAGMENT) from Mycobacterium paratuberculosis (245 aa), FASTA scores: opt: 1018, E(): 4.8e-57, (73.95% identity in 211 aa overlap); and Q50203|GIDB_MYCLE|ML2708 GLUCOSE INHIBITED DIVISION PROTEIN B from Mycobacterium leprae (245 aa), FASTA scores: opt: 966, E(): 9.1e-54, (68.4% identity in 212 aa overlap). Also highly similar to many e.g. O54571|GIDB_STRCO|STH24.07 from Streptomyces coelicolor (239 aa), FASTA scores: opt: 654, E(): 3.9e-34, (47.95% identity in 221 aa overlap); Q9KNG5|VC2774 from Vibrio cholerae (210 aa), FASTA scores: opt: 300, E(): 6.9e-12,(38.15% identity in 139 aa overlap); P17113|GIDB_ECOLI|B3740|Z5240|ECS4682 from Escherichia coli (several strains) (207 aa), FASTA scores: opt: 287,E(): 4.5e-11, (34.8% identity in 138 aa overlap); etc. Contains PS00539 Pyrokinins signature. BELONGS TO THE GIDB FAMILY. X2BPQ3,P59964 No NC_002945.3 Mycobrowser_v2 CDS 4342294 4342857 . - 0 Mb3951c conserved protein similar to jag protein Mb3951c, -, len: 187 aa. Equivalent to Rv3920c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Hypothetical protein,similar to JAG protein, equivalent to Q9L7M2 HYPOTHETICAL 20.1 KDA PROTEIN from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 HYPOTHETICAL PROTEIN SIMILAR TO JAG PROTEIN SPOIIIJ ASSOCIATED PROTEIN IN BACILLUS SUBTILIS from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44,(73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|JAG JAG-LIKE PROTEIN from Streptomyces coelicolor (170 aa), FASTA scores: opt: 593, E(): 6.7e-28, (62.85% identity in 167 aa overlap); Q9RCA6|JAG|BH4063 JAG PROTEIN HOMOLOG from Bacillus halodurans (207 aa), FASTA scores: opt: 282, E(): 1.1e-09, (35.0% identity in 140 aa overlap); Q9X1H1|TM1460 PUTATIVE JAG PROTEIN, PUTATIVE from Thermotoga maritima (221 aa), FASTA scores: opt: 258, E(): 3e-08, (31.9% identity in 138 aa overlap);Q01620|JAG_BACSU JAG PROTEIN (SPOIIIJ ASSOCIATED PROTEIN) from Bacillus subtilis (208 aa), FASTA scores: opt: 196, E(): 0.00012, (28.05% identity in 139 aa overlap); etc. Q7TVC4 No conserved hypotheticals Rv3920c NC_002945.3 Mycobrowser_v2 CDS 4342929 4344029 . - 0 Mb3952c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb3952c, -, len: 366 aa. Equivalent to Rv3921c,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 366 aa overlap). Probable conserved transmembrane protein, equivalent to Q9L7M1 HYPOTHETICAL 39.2 KDA PROTEIN from Mycobacterium paratuberculosis (353 aa), FASTA scores: opt: 2001, E(): 8.4e-100, (83.05% identity in 366 aa overlap); Q9CCX6|ML2710 PUTATIVE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (380 aa), FASTA scores: opt: 1929, E(): 6.2e-96, (77.1% identity in 380 aa overlap); Q50205 CDS 27 on L222 from Mycobacterium leprae (312 aa) FASTA scores: opt: 1770,E(): 1.6e-87, (88.2% identity in 288 aa overlap). Also similar to other e.g. O54569|STH24.05 INNER MEMBRANE PROTEIN. from Streptomyces coelicolor (431 aa), FASTA scores: opt: 412, E(): 6.5e-15, (33.45% identity in 266 aa overlap); O84253|CT251 60 KDA INNER MEMBRANE PROTEIN from Chlamydia trachomatis (787 aa), FASTA scores: opt: 304,E(): 6e-09, (27.9% identity in 269 aa overlap); P29431|60IM_BUCAP 60 KDA INNER-MEMBRANE PROTEIN HOMOLOG from Buchnera aphidicola (subsp. Schizaphis graminum) (536 aa), FASTA scores: opt: 282, E(): 6.7e-08, (36.1% identity in 108 aa overlap); etc. X2BPQ9,P65627 No cell wall and cell processes Rv3921c NC_002945.3 Mycobrowser_v2 CDS 4344013 4344375 . - 0 Mb3953c POSSIBLE HEMOLYSIN Mb3953c, -, len: 120 aa. Equivalent to Rv3922c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). Possible hemolysin,highly similar to Q9L7M0|YIDD_MYCPA HYPOTHETICAL 12.4 KDA PROTEIN from Mycobacterium paratuberculosis (115 aa),FASTA scores: opt: 521, E(): 1.9e-29, (65.2% identity in 112 aa overlap). Also highly similar to Q44066|HLYA_AERHY PUTATIVE ALPHA-HEMOLYSIN from Aeromonas hydrophila (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap); and to many bacterial hypothetical proteins from bacterium e.g. P22847|YIDD_ECOLI|B3704.1 HYPOTHETICAL PROTEIN from Escherichia coli strain K12 (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap). X2BQ10,P67301 No virulence, detoxification, adaptation Rv3922c NC_002945.3 Mycobrowser_v2 CDS 3282790 3283638 . + 0 Mb2996 PROBABLE OXIDOREDUCTASE Mb2996, -, len: 282 aa. Equivalent to Rv2971, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly aldo/keto reductase,equivalent to O69462 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495,E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C OXIDOREDUCTASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 849, E(): 1.2e-49, (51.7% identity in 267 aa overlap); Q9ZBW7|SC4B5.01C PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49,(49.1% identity in 271 aa overlap); Q46857|YQHE_ECOLI|YQHE|B3012 HYPOTHETICAL OXIDOREDUCTASE from Escherichia coli strain K12 (275 aa), FASTA scores: opt: 827, E(): 3.7e-48, (47.45% identity in 276 aa overlap); etc. Contains PS00063 Aldo X2BMD1,Q7TXI6 No intermediary metabolism and respiration Rv2971 NC_002945.3 Mycobrowser_v2 CDS 3392345 3392869 . - 0 Mb3099c CONSERVED HYPOTHETICAL PROTEIN Mb3099c, -, len: 174 aa. Equivalent to Rv3072c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Hypothetical protein,similar in part to O87779 HYPOTHETICAL 18.1 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (166 aa),FASTA scores: opt: 238, E(): 2.5e-08, (42.6% identity in 108 aa overlap); Q9AH10 PUTATIVE F420-DEPENDENT DEHYDROGENASE from Rhodococcus erythropolis (295 aa),FASTA scores: opt: 228, E(): 1.7e-07, (34.25% identity in 111 aa overlap); P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 POSSIBLE OXIDOREDUCTASE from Mycobacterium tuberculosis strain H37Rv (304 aa), FASTA scores: opt: 208, E(): 3.2e-06, (38.9% identity in 108 aa overlap); etc. N-terminal region similar to several proteins from M. tuberculosis (see MAST results on the web site http: Q7TXB6 No conserved hypotheticals Rv3072c NC_002945.3 Mycobrowser_v2 CDS 4186173 4187300 . + 0 Mb3825 conserved protein Mb3825, -, len: 375 aa. Equivalent to Rv3796, len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 375 aa overlap). Conserved hypothetical protein. C-terminal end similar in part to Q983J3|MLR8305 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (227 aa), FASTA scores: opt: 288, E(): 4e-09,(38.95% identity in 154 aa overlap). Similar to P54548|YQJK_BACSU HYPOTHETICAL PROTEIN (BELONGS TO THE ATSA/ELAC FAMILY) from Bacillus subtilis (307 aa) FASTA scores: opt: 263, E(): 1.3e-07, (26.1% identity in 295 aa overlap); and some similarity to other proteins e.g. AAK46775|MT2479 PUTATIVE ARYLSULFATASE from Mycobacterium tuberculosis strain CDC1551 (224 aa), FASTA scores: opt: 194, E(): 0.00072, (25.85% identity in 259 aa overlap). Equivalent to AAK48269 from Mycobacterium tuberculosis strain CDC1551 (338 aa) but longer 37 aa. SOME SIMILARITY TO THE A. CARRAGEENOVORA ATSA Q7TVN2 No conserved hypotheticals Rv3796 NC_002945.3 Mycobrowser_v2 CDS 2523243 2523575 . - 0 Mb2292c HYPOTHETICAL PROTEIN Mb2292c, -, len: 110 aa. Equivalent to Rv2269c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Unknown protein. X2BKC5 No conserved hypotheticals Rv2269c NC_002945.3 Mycobrowser_v2 CDS 1244235 1244384 . - 0 Mb1150c HYPOTHETICAL PROTEIN Mb1150c, -, len: 49 aa. Equivalent to Rv1119c, len: 49 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 49 aa overlap). Hypothetical unknown protein. Q7U0L9 No conserved hypotheticals Rv1119c NC_002945.3 Mycobrowser_v2 CDS 1263293 1263529 . + 0 Mb1165 HYPOTHETICAL PROTEIN Mb1165, -, len: 78 aa. Equivalent to Rv1134, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 78 aa overlap). Hypothetical unknown protein. Q7U0K6 No conserved hypotheticals Rv1134 NC_002945.3 Mycobrowser_v2 tRNA 1177844 1177917 . + 0 leuX leuX tRNA-Leu leuX, len: 74 nt. Equivalent to leuX, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Leu, anticodon taa. No NC_002945.3 Mycobrowser_v2 tRNA 1813381 1813454 . - 0 leuV leuV tRNA-Leu leuV, len: 74 nt. Equivalent to leuV, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Leu, anticodon caa. No NC_002945.3 Mycobrowser_v2 tRNA 2559359 2559432 . - 0 metV metV tRNA-Met metV, len: 74 nt. Equivalent to metV, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Met, anticodon cat. No NC_002945.3 Mycobrowser_v2 tRNA 2597004 2597076 . - 0 asnT asnT tRNA-Asn asnT, len: 73 nt. Equivalent to asnT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Asn, anticodon gtt. No NC_002945.3 Mycobrowser_v2 CDS 2694029 2694229 . - 0 Mb2453c Mb2453c, -, len: 66 aa. Equivalent to the first part of oxyR' pseudogene (see citation below). No NC_002945.3 Mycobrowser_v2 tRNA 2733494 2733567 . - 0 proU proU tRNA-Pro proU, len: 74 nt. Equivalent to proU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro; anticodon tgg. No NC_002945.3 Mycobrowser_v2 CDS 2817888 2818115 . + 0 Mb2555 vapb17 possible antitoxin vapb17 Mb2555, -, len: 75 aa. Equivalent to Rv2526, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in aa overlap). Hypothetical unknown protein. Q7TYD6 No virulence, detoxification, adaptation Rv2526 NC_002945.3 Mycobrowser_v2 CDS 3624559 3624936 . - 0 Mb3317c POSSIBLE TRANSMEMBRANE PROTEIN Mb3317c, -, len: 125 aa. Equivalent to Rv3289c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Possible transmembrane protein, showing slight similarity to other membrane proteins or glycoproteins. Q7TWT3 No cell wall and cell processes Rv3289c NC_002945.3 Mycobrowser_v2 CDS 1800619 1801059 . + 0 Mb1641 probable membrane protein Mb1641, -, len: 146 aa. Equivalent to Rv1615, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Probable membrane protein. Q7VEW4 No cell wall and cell processes Rv1615 NC_002945.3 Mycobrowser_v2 tRNA 1444242 1444314 . - 0 argV argV tRNA-Arg argV, len: 73 nt. Equivalent to argV, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon ccg. No NC_002945.3 Mycobrowser_v2 tRNA 25625 25707 . + 0 leuT leuT tRNA-Leu leuT, len: 83 nt. Equivalent to leuT, len: 83 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 83 nt overlap). tRNA-Leu, anticodon cag. No NC_002945.3 Mycobrowser_v2 CDS 87243 87836 . - 0 Mb0081c HYPOTHETICAL PROTEIN Mb0081c, -, len: 197 aa. Equivalent to Rv0078A,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Hypothetical unknown protein. Q7U2W4 No conserved hypotheticals Rv0078A NC_002945.3 Mycobrowser_v2 CDS 162454 162693 . + 0 Mb0139-3 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-3, -, len: 80 aa. Pseudogene part3 of Rv0134/ephF No NC_002945.3 Mycobrowser_v2 CDS 238088 238591 . - 0 Mb0207c conserved protein Mb0207c, -, len: 167 aa. Equivalent to Rv0201c,len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622.15c from Mycobacterium leprae (170 aa), FASTA scores: opt: 646, E(): 0, (63.9% identity in 158 aa overlap). Q7U2K9 No conserved hypotheticals Rv0201c NC_002945.3 Mycobrowser_v2 CDS 1266458 1266826 . - 0 Mb1169c HYPOTHETICAL PROTEIN Mb1169c, -, len: 122 aa. Equivalent to Rv1137c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 122 aa overlap). Hypothetical unknown protein. Q7U0K2 No conserved hypotheticals Rv1137c NC_002945.3 Mycobrowser_v2 CDS 445861 446250 . - 0 Mb0374c HYPOTHETICAL PROTEIN Mb0374c, -, len: 129 aa. Equivalent to Rv0367c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Hypothetical unknown protein. Q7U260 No conserved hypotheticals Rv0367c NC_002945.3 Mycobrowser_v2 CDS 607300 607599 . + 0 Mb0527 POSSIBLE TRANSMEMBRANE PROTEIN Mb0527, -, len: 99 aa. Equivalent to Rv0514, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Possible transmembrane protein. Q7U1V8 No cell wall and cell processes Rv0514 NC_002945.3 Mycobrowser_v2 CDS 732349 732600 . + 0 Mb0652 unknown protein Mb0652, -, len: 83 aa. Equivalent to Rv0634A, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Hypothetical unknown protein. Q7U1K5 No conserved hypotheticals Rv0634A NC_002945.3 Mycobrowser_v2 tRNA 732730 732802 . + 0 thrT thrT tRNA-Thr thrT, len: 73 nt. Equivalent to thrT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Thr, anticodon ggt. No NC_002945.3 Mycobrowser_v2 CDS 787918 788715 . + 0 Mb0705 PROBABLE MEMBRANE PROTEIN Mb0705, -, len: 265 aa. Equivalent to Rv0686, len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 265 aa overlap). Probable membrane protein, with hydrophobic N-terminus. Q7U1G9 No cell wall and cell processes Rv0686 NC_002945.3 Mycobrowser_v2 tRNA 852832 852903 . - 0 thrV thrV tRNA-Thr thrV, len: 72 nt. Equivalent to thrV, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Thr, anticodon tgt. No NC_002945.3 Mycobrowser_v2 CDS 1372164 1372721 . + 0 Mb1260 lpqX probable lipoprotein lpqx Mb1260, lpqX, len: 185 aa. Equivalent to Rv1228,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 185 aa overlap). Probable lipoprotein LpqX. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U0C3 No cell wall and cell processes Rv1228 NC_002945.3 Mycobrowser_v2 CDS 945098 945490 . + 0 Mb0870 lpqS PROBABLE LIPOPROTEIN LPQS Mb0870, lpqS, len: 130 aa. Equivalent to Rv0847,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 130 aa overlap). Probable lpqS,lipoprotein. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U146 No cell wall and cell processes Rv0847 NC_002945.3 Mycobrowser_v2 CDS 2508042 2508236 . - 0 Mb2279c HYPOTHETICAL PROTEIN Mb2279c, -, len: 64 aa. Equivalent to Rv2255c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Hypothetical unknown protein. Q7TYW3 No conserved hypotheticals Rv2255c NC_002945.3 Mycobrowser_v2 CDS 1052827 1053105 . + 0 Mb0967 HYPOTHETICAL PROTEIN Mb0967, -, len: 92 aa. Equivalent to Rv0942, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 92 aa overlap). Hypothetical unknown protein. X2BGM0 No conserved hypotheticals Rv0942 NC_002945.3 Mycobrowser_v2 CDS 1076635 1077117 . - 0 Mb0989c HYPOTHETICAL PROTEIN Mb0989c, -, len: 160 aa. Equivalent to Rv0964c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 160 aa overlap). Hypothetical unknown protein. Equivalent to AAK45241.1 from Mycobacterium tuberculosis strain CDC1551 (138 aa) but longer 22 aa. X2BGQ4 No conserved hypotheticals Rv0964c NC_002945.3 Mycobrowser_v2 CDS 1536425 1537246 . + 0 Mb1401 HYPOTHETICAL PROTEIN Mb1401, -, len: 273 aa. Equivalent to Rv1366, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Hypothetical unknown protein. X2BHW3,P64834 No conserved hypotheticals Rv1366 NC_002945.3 Mycobrowser_v2 CDS 1589812 1590285 . + 0 Mb1454 unknown protein Mb1454, -, len: 157 aa. Equivalent to Rv1419, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 157 aa overlap). Hypothetical unknown protein. X2BHK4,P64850 No conserved hypotheticals Rv1419 NC_002945.3 Mycobrowser_v2 CDS 2194652 2195266 . - 0 Mb1993c HYPOTHETICAL PROTEIN Mb1993c, -, len: 204 aa. Equivalent to Rv1958c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Hypothetical unknown protein. Q7TZ74 No conserved hypotheticals Rv1958c NC_002945.3 Mycobrowser_v2 CDS 1676068 1677375 . + 0 Mb1527 PROBABLE MEMBRANE PROTEIN Mb1527, -, len: 435 aa. Equivalent to Rv1490, len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 435 aa overlap). Probable membrane protein. X2BIJ5,P64858 No cell wall and cell processes Rv1490 NC_002945.3 Mycobrowser_v2 CDS 1730932 1731159 . + 0 Mb1572 HYPOTHETICAL PROTEIN Mb1572, -, len: 75 aa. Equivalent to Rv1545, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Hypothetical unknown protein. X2BIN7 No conserved hypotheticals Rv1545 NC_002945.3 Mycobrowser_v2 CDS 1737503 1739446 . + 0 Mb1576 fadD11 probable fatty-acid-coa ligase fadd11 (fatty-acid-coa synthetase) (fatty-acid-coa synthase) Mb1576, fadD11, len: 647 aa. Equivalent to Rv1549 (fadD11') and Rv1550 (fadD11), len: 175 aa and 571 aa,from Mycobacterium tuberculosis strain H37Rv, (100% identity in 167 aa overlap and 99.8% identity in 470 aa overlap). Possible fadD11', fatty-acid-CoA synthetase (EC 6.2.1.-), similar to the N-terminus of many fatty-acid CoA synthetases e.g. NP_147860.1|NC_000854 long-chain-fatty-acid--CoA ligase from Aeropyrum pernix (651 aa); P31685|4CL2_SOLTU 4-coumarate--CoA ligase 2 (EC 6.2.1.12) from Solanum tuberosum (Potato) (545 aa), FASTA scores: opt: 168, E(): 4.4e-06, (30.4% identity in 112 aa overlap); etc. Possible frameshift with respect to next ORF Rv1550|MTCY48.15c but we can find no sequence error to account for this. Probable fadD11, fatty-acid-CoA synthetase (EC 6.2.1.-), similar, except in N-terminus, to many e.g. SC6A5.39|T35430 probable long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) from Streptomyces coelicolor (612 aa); NP_301672.1|NC_002677 putative long-chain-fatty-acid-CoA ligase from Mycobacterium leprae (600 aa); P44446|LCFH_HAEIN putative long-chain-fatty-acid-CoA ligase from Haemophilus influenzae (607 aa), FASTA scores: opt: 762, E(): 2.3e-38,(34.4% identity in 436 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis, a two single base insertions (*-c and *-c) lead to a single product. Q7TZX2 No lipid metabolism Rv1549 NC_002945.3 Mycobrowser_v2 CDS 1760226 1760510 . - 0 Mb1594c probable hypothetical membrane protein Mb1594c, -, len: 94 aa. Equivalent to Rv1567c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Probable membrane protein. Q7VEY4 No cell wall and cell processes Rv1567c NC_002945.3 Mycobrowser_v2 CDS 1768675 1768989 . - 0 Mb1605c Probable phiRv1 phage protein Mb1605c, -, len: 104 aa. Equivalent to Rv1579c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 104 aa overlap). Probable phiRv1 phage protein (see citation below). Q7VEX7 No insertion seqs and phages Rv1579c NC_002945.3 Mycobrowser_v2 CDS 1881121 1881483 . + 0 Mb1696 HYPOTHETICAL PROTEIN Mb1696, -, len: 120 aa. Equivalent to Rv1669, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 120 aa overlap). Hypothetical unknown protein. Q7TZU1 No conserved hypotheticals Rv1669 NC_002945.3 Mycobrowser_v2 tRNA 1931953 1932026 . + 0 proT proT tRNA-Pro proT, len: 74 nt. Equivalent to proT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro, anticodon ggg. No NC_002945.3 Mycobrowser_v2 CDS 1935972 1936391 . - 0 Mb1753c HYPOTHETICAL PROTEIN Mb1753c, -, len: 139 aa. Equivalent to Rv1724c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 139 aa overlap). Hypothetical unknown protein. Q7TZQ0 No conserved hypotheticals Rv1724c NC_002945.3 Mycobrowser_v2 CDS 2049896 2049976 . + 0 Mb1847 CONSERVED HYPOTHETICAL PROTEIN Mb1847, -, len: 26 aa. Equivalent to Rv1816A, len: 26 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 26 aa overlap). Conserved hypothetical protein. Q7TZH2 No Rv1816A NC_002945.3 Mycobrowser_v2 CDS 2113893 2114579 . + 0 Mb1905 unknown protein Mb1905, -, len: 228 aa. Equivalent to Rv1874, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Hypothetical unknown protein. Q7TZE2 No conserved hypotheticals Rv1874 NC_002945.3 Mycobrowser_v2 CDS 2192857 2193378 . - 0 Mb1989c HYPOTHETICAL PROTEIN Mb1989c, -, len: 173 aa. Equivalent to Rv1954c,len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 173 aa overlap). Hypothetical unknown protein, end overlaps next ORF upstream, Rv1955 (MTCY09F9.09c). Q7TZ78 No conserved hypotheticals Rv1954c NC_002945.3 Mycobrowser_v2 CDS 2314923 2315174 . - 0 Mb2101c conserved hypothetical protein Mb2101c, -, len: 83 aa. Equivalent to Rv2076c, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Unknown, questionable ORF X2BJN0,P64932 No conserved hypotheticals Rv2076c NC_002945.3 Mycobrowser_v2 CDS 2693723 2694028 . - 0 Mb2452c Mb2452c, -, len: 101 aa. Equivalent to the second part of oxyR' pseudogene (see citation below). No NC_002945.3 Mycobrowser_v2 CDS 2922521 2922883 . + 0 Mb2661 HYPOTHETICAL PROTEIN Mb2661, -, len: 120 aa. Equivalent to Rv2628, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 120 aa overlap). Hypothetical unknown protein. Q7TY70 No conserved hypotheticals Rv2628 NC_002945.3 Mycobrowser_v2 CDS 2954688 2956604 . - 0 Mb2701c dxs1 PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) Mb2701c, dxs1, len: 638 aa. Equivalent to Rv2682c,len: 638 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 638 aa overlap). Probable dxs1,1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-),equivalent to Q50000|DXS_MYCLE|TKTB|ML1038 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE from Mycobacterium leprae (643 aa), FASTA scores: opt: 3635, E(): 5.6e-209,(86.4% identity in 632 aa overlap). Also highly similar to other Q9X7W3|DXS_STRCO|DXS|SC6A5.17 from Streptomyces coelicolor (656 aa), FASTA scores: opt: 2501, E(): 2e-141,(61.3% identity in 623 aa overlap); Q9K971|DXS_BACHD|DXS|BH2779 from Bacillus halodurans (629 aa), FASTA scores: opt: 1612, E(): 1.8e-88, (41.35% identity in 619 aa overlap); P77488|DXS_ECOLI|DXS|B0420 from Escherichia coli strain K12 (619 aa), FASTA scores: opt: 1511, E(): 1.8e-82, (39.5% identity in 625 aa overlap); etc. Also similar to O50408|Rv3379c|MTV004.37c from Mycobacterium tuberculosis (536 aa). BELONGS TO THE TRANSKETOLASE FAMILY. DXS SUBFAMILY. COFACTOR: THIAMINE PYROPHOSPHATE. Note that previously known as dxs. X2BLJ2,P0A555 No NC_002945.3 Mycobrowser_v2 CDS 2976836 2977093 . - 0 Mb2725c HYPOTHETICAL PROTEIN Mb2725c, -, len: 85 aa. Equivalent to Rv2706c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Hypothetical unknown protein. Q7TY24 No conserved hypotheticals Rv2706c NC_002945.3 Mycobrowser_v2 CDS 2999178 2999654 . + 0 Mb2749 HYPOTHETICAL PROTEIN Mb2749, -, len: 158 aa. Equivalent to Rv2730, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Hypothetical unknown protein. Q7TY08 No conserved hypotheticals Rv2730 NC_002945.3 Mycobrowser_v2 CDS 3085535 3085909 . - 0 Mb2846c HYPOTHETICAL PROTEIN Mb2846c, -, len: 124 aa. Equivalent to Rv2822c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Hypothetical unknown protein. Q7TXS5 No conserved hypotheticals Rv2822c NC_002945.3 Mycobrowser_v2 CDS 3134338 3134601 . + 0 Mb2891 relg toxin relg Mb2891, -, len: 87 aa. Equivalent to Rv2866, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Conserved hypothetical protein, similar to O50461|Rv1246c|MTV006.18c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 aa), FASTA scores: opt: 290, E(): 3.6e-16, (54.1% identity in 85 aa overlap). Q7TXN8 No virulence, detoxification, adaptation Rv2866 NC_002945.3 Mycobrowser_v2 CDS 3332373 3333002 . + 0 Mb3041 lpqA PROBABLE LIPOPROTEIN LPQA Mb3041, lpqA, len: 209 aa. Equivalent to Rv3016,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable lpqA,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7TXF9 No cell wall and cell processes Rv3016 NC_002945.3 Mycobrowser_v2 CDS 3334888 3334974 . - 0 Mb3044c PE27A pe family protein pe27a Mb3044c, PE27A, len: 28 aa. Equivalent to Rv3018A,len: 28 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 28 aa overlap). Member of M. tuberculosis PE family, most similar to Rv0285 (102 aa),FASTA scores: opt: 147, E(): 3.5e-05, (92.85% identity in 28 aa overlap); etc. Q7VEL4 No NC_002945.3 Mycobrowser_v2 tRNA 3388387 3388459 . - 0 alaU alaU tRNA-Ala alaU, len: 73 nt. Equivalent to alaU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon ggc. No NC_002945.3 Mycobrowser_v2 CDS 3433608 3434048 . + 0 Mb3135 HYPOTHETICAL PROTEIN Mb3135, -, len: 146 aa. Equivalent to Rv3108, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Hypothetical unknown protein. Q7TX85 No conserved hypotheticals Rv3108 NC_002945.3 Mycobrowser_v2 CDS 3445580 3445894 . - 0 Mb3149c HYPOTHETICAL PROTEIN Mb3149c, -, len: 104 aa. Equivalent to Rv3126c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Hypothetical unknown protein. Shortened version of MTCY164.36c, avoiding overlap. Q7TX75 No conserved hypotheticals Rv3126c NC_002945.3 Mycobrowser_v2 CDS 3498133 3498615 . - 0 Mb3197c HYPOTHETICAL PROTEIN Mb3197c, -, len: 160 aa. Equivalent to Rv3172c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein. Q7TX40 No conserved hypotheticals Rv3172c NC_002945.3 Mycobrowser_v2 CDS 3521231 3521431 . - 0 Mb3219c unknown protein Mb3219c, -, len: 66 aa. Equivalent to Rv3196A, len: 66 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 66 aa overlap). Hypothetical unknown protein. Q7TX18 No conserved hypotheticals Rv3196A NC_002945.3 Mycobrowser_v2 CDS 3576849 3577691 . - 0 Mb3271c unknown protein Mb3271c, -, len: 280 aa. Equivalent to Rv3243c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Hypothetical unknown protein. Q7TWX0 No conserved hypotheticals Rv3243c NC_002945.3 Mycobrowser_v2 CDS 3565900 3566541 . + 0 Mb3263 HYPOTHETICAL ALANINE ARGININE PROLINE RICH PROTEIN Mb3263, -, len: 213 aa. Equivalent to Rv3235, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Hypothetical unknown ala-, arg-, pro-rich protein. Q7TWX7 No conserved hypotheticals Rv3235 NC_002945.3 Mycobrowser_v2 CDS 3741366 3742256 . + 0 Mb3408 echA18 probable enoyl-coa hydratase (fragment) echa18.1 (enoyl hydrase) (unsaturated acyl-coa hydratase) (crotonase) Mb3408, echA18, len: 296 aa. Equivalent to Rv3373 and Rv3374, len: 213 aa and 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 213 aa overlap and 100.0% identity in 82 aa overlap). Rv3373: Probable echA18, enoyl-CoA hydratase (EC 4.2.1.17),similar to others e.g. P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 423,E(): 3.4e-20, (37.95% identity in 174 aa overlap); Q9X7Q4|SC5F2A.31c from Streptomyces coelicolor (257 aa),FASTA scores: opt: 399, E(): 1.2e-18, (45.05% identity in 171 aa overlap); BAB52005|MLL5584 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 385,E(): 9.6e-18, (41.95% identity in 174 aa overlap); etc. Also some similarity to 3-HYDROXYBUTYRYL-COA DEHYDRATASES (EC 4.2.1.55) e.g. P52046|CRT_CLOAB from Clostridium acetobutylicum (261 aa), FASTA scores: opt: 414, E(): 1.3e-19, (38.3% identity in 175 aa overlap). And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE (257 aa), FASTA scores: opt: 365, E(): 1.9e-16, (39.1% identity in 174 aa overlap). BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Note that this homology extends across the stop codon and directly into the next ORF MTV004.29, suggesting a possible readthrough of the TGA stop codon. Rv3374: Probable echA18', enoyl-CoA hydratase C-terminus (EC 4.2.1.17), similar to the C-terminus of several enoyl-CoA hydratases e.g. Q9I5I4|PA0745 from Pseudomonas aeruginosa (272 aa), FASTA scores: opt: 123, E(): 0.13, (34.55% identity in 81 aa overlap); P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 115,E(): 0.45, (32.95% identity in 82 aa overlap); Q9I002|PA2841 from Pseudomonas aeruginosa (263 aa), FASTA scores: opt: 108, E(): 1.4, (30.95% identity in 84 aa overlap); etc. Also some similarity to C-terminus of O29956|AF0285 3-HYDROXYACYL-COA DEHYDROGENASE from Archaeoglobus fulgidus (658 aa), FASTA scores: opt: 116,E(): 0.81, (34.15% identity in 82 aa overlap); and other enzymes. And similar to other hydratases from M. tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE (257 aa), FASTA scores: opt: 111, E(): 0.83, (36.05% identity in 86 aa overlap). This homology extends across the upstream TGA stop codon into the upstream ORF MTV004.28, suggesting possible readthrough of the previous stop codon. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis, a single base transversion (t-g) leads to a single product. Q7TWL6 No lipid metabolism Rv3373 NC_002945.3 Mycobrowser_v2 CDS 3807367 3807678 . - 0 Mb3470c HYPOTHETICAL PROTEIN Mb3470c, -, len: 103 aa. Equivalent to Rv3440c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Hypothetical unknown protein. Q7TWI0 No conserved hypotheticals Rv3440c NC_002945.3 Mycobrowser_v2 CDS 3855513 3856091 . + 0 Mb3521 unknown protein Mb3521, -, len: 192 aa. Equivalent to Rv3491, len: 192 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 192 aa overlap). Hypothetical unknown protein. No significant homology with other proteins. Q7TWE0 No conserved hypotheticals Rv3491 NC_002945.3 Mycobrowser_v2 CDS 3911032 3912159 . - 0 Mb3561c HYPOTHETICAL PROTEIN Mb3561c, -, len: 375 aa. Equivalent to Rv3531c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Hypothetical unknown protein. Q7TWA0 No conserved hypotheticals Rv3531c NC_002945.3 Mycobrowser_v2 CDS 3997011 3997172 . - 0 Mb3643c HYPOTHETICAL PROTEIN Mb3643c, -, len: 53 aa. Equivalent to Rv3613c, len: 53 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 53 aa overlap). Hypothetical unknown protein. Q7TW36 No conserved hypotheticals Rv3613c NC_002945.3 Mycobrowser_v2 tRNA 4018602 4018674 . - 0 thrU thrU tRNA-Thr thrU, len: 73 nt. Equivalent to thrU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Thr, anticodon cgt. No NC_002945.3 Mycobrowser_v2 tRNA 4063888 4063961 . + 0 proY proY tRNA-Pro proY, len: 74 nt. Equivalent to proY, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro, anticodon cgg. No NC_002945.3 Mycobrowser_v2 tRNA 4158876 4158962 . - 0 serU serU tRNA-Ser serU, len: 87 nt. Equivalent to serU, len: 87 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 87 nt overlap). tRNA-Ser, anticodon tga. No NC_002945.3 Mycobrowser_v2 CDS 4220269 4220604 . + 0 Mb3849 unknown protein Mb3849, -, len: 111 aa. Equivalent to Rv3819, len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Hypothetical unknown protein. Contains PS00012 Phosphopantetheine attachment site. Q7TVL4 No conserved hypotheticals Rv3819 NC_002945.3 Mycobrowser_v2 CDS 4274219 4274545 . + 0 Mb3891 HYPOTHETICAL PROTEIN Mb3891, -, len: 108 aa. Equivalent to Rv3861, len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Hypothetical unknown protein. Q7TVH5 No conserved hypotheticals Rv3861 NC_002945.3 Mycobrowser_v2 CDS 4242030 4242512 . + 0 Mb3861 HYPOTHETICAL PROTEIN Mb3861, -, len: 160 aa. Equivalent to Rv3831, len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein. Q7TVK2 No conserved hypotheticals Rv3831 NC_002945.3 Mycobrowser_v2 CDS 4255554 4255913 . + 0 Mb3875 HYPOTHETICAL PROTEIN Mb3875, -, len: 119 aa. Equivalent to Rv3845, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical unknown protein. Contains PS01137 Hypothetical YBL055c/yjjV family signature 1. Q7TVJ0 No conserved hypotheticals Rv3845 NC_002945.3 Mycobrowser_v2 CDS 4321326 4321856 . - 0 Mb3932c HYPOTHETICAL PROTEIN Mb3932c, -, len: 176 aa. Equivalent to Rv3902c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Hypothetical unknown protein. Q7TVD9 No conserved hypotheticals Rv3902c NC_002945.3 Mycobrowser_v2 CDS 4334830 4335594 . + 0 Mb3943 HYPOTHETICAL ALANINE RICH PROTEIN Mb3943, -, len: 254 aa. Equivalent to Rv3912, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Hypothetical unknown ala-rich protein. Q7TVC9 No conserved hypotheticals Rv3912 NC_002945.3 Mycobrowser_v2 CDS 1282215 1282856 . - 0 Mb1185c HYPOTHETICAL PROTEIN Mb1185c, -, len: 213 aa. Equivalent to Rv1154c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 213 aa overlap). Hypothetical unknown protein, start uncertain. Q7U0I8 No conserved hypotheticals Rv1154c NC_002945.3 Mycobrowser_v2 CDS 2189658 2190059 . + 0 Mb1982 HYPOTHETICAL PROTEIN Mb1982, -, len: 133 aa. Equivalent to Rv1947, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Hypothetical unknown protein Q7TZ85 No conserved hypotheticals Rv1947 NC_002945.3 Mycobrowser_v2 CDS 2190348 2190698 . - 0 Mb1983c HYPOTHETICAL PROTEIN Mb1983c, -, len: 116 aa. Equivalent to Rv1948c,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 116 aa overlap). Hypothetical unknown protein Q7TZ84 No conserved hypotheticals Rv1948c NC_002945.3 Mycobrowser_v2 CDS 3307885 3309222 . + 0 Mb3018 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb3018, -, len: 445 aa. Equivalent to Rv2994, len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug. C-terminal part highly similar to O33118|MLCB637.27c HYPOTHETICAL 14.7 KDA PROTEIN (probable pseudogene product) from Mycobacterium leprae (134 aa), FASTA scores: opt: 483, E(): 2.7e-21, (60.9% identity in 138 aa overlap). Also similar to various transporters e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 289, E(): 1.3e-09,(26.05% identity in 399 aa overlap); O30210|AF0025 CYANATE TRANSPORT PROTEIN from Archaeoglobus fulgidus (393 aa),FASTA scores: opt: 281, E(): 3.7e-09, (24.05% identity in 399 aa overlap); Q9RI35|SCJ12.25C PUTATIVE NITRATE/NITRITE TRANSPORTER from Streptomyces coelicolor (412 aa), FASTA scores: opt: 264, E(): 3.8e-08, (24.95% identity in 409 aa overlap); Q9A5N5|CC2412 MAJOR FACILITATOR FAMILY TRANSPORTER from Caulobacter crescentus (405 aa), FASTA scores: opt: 263, E(): 4.3e-08, (27.55% identity in 399 aa overlap); etc. First start taken; similarity to P21191|NORA_STAAU QUINOLONE RESISTANCE PROTEIN from Staphylococcus aureus (388 aa) suggests alternative start at 7319 but then no positively charged aa before first transmembrane segment. Q7TVB6 No cell wall and cell processes Rv2994 NC_002945.3 Mycobrowser_v2 CDS 1355490 1355717 . + 0 Mb1243 conserved protein Mb1243, -, len: 75 aa. Equivalent to Rv1211, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Conserved hypothetical protein, similar to Q49958|U1756N Mycobacterium leprae (75 aa), FASTA scores: opt: 460, E(): 0, (90.7% identity in 75 aa overlap). Q7U0D8 No conserved hypotheticals Rv1211 NC_002945.3 Mycobrowser_v2 CDS 2490838 2491428 . - 0 Mb2264c unknown protein Mb2264c, len: 196 aa. Equivalent to Rv2240c len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 196 aa overlap). Unknown protein. Start changed since first submission (-69 aa). X2BKI1 No conserved hypotheticals Rv2240c NC_002945.3 Mycobrowser_v2 tRNA 2489746 2489817 . - 0 valV valV tRNA-Val valV, len: 72 nt. Equivalent to valV, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Val, anticodon tac. No NC_002945.3 Mycobrowser_v2 CDS 2489499 2489735 . - 0 Mb2261A Conserved protein Mb2261A, len: 78 aa. Equivalent to Rv2237A len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 78 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BKJ1 No conserved hypotheticals Rv2237A NC_002945.3 Mycobrowser_v2 CDS 4151494 4152069 . - 0 Mb3796c HYPOTHETICAL LEUCINE RICH PROTEIN Mb3796c, -, len: 191 aa. Equivalent to Rv3770c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 191 aa overlap). Hypothetical unknown leu-rich protein. Q7TVQ4 No conserved hypotheticals Rv3770c NC_002945.3 Mycobrowser_v2 tRNA 11112 11184 . + 0 alaT alaT tRNA-Ala alaT, len: 73 nt. Equivalent to alaT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon tgc. No NC_002945.3 Mycobrowser_v2 CDS 3083926 3084834 . - 0 Mb2844c HYPOTHETICAL PROTEIN Mb2844c, -, len: 302 aa. Equivalent to Rv2820c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Hypothetical unknown protein. Q7TXS7 No conserved hypotheticals Rv2820c NC_002945.3 Mycobrowser_v2 CDS 11874 12311 . - 0 Mb0008c POSSIBLE MEMBRANE PROTEIN Mb0008c, -, len: 145 aa. Equivalent to Rv0008c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible membrane protein. X2BDR6,P59977 No cell wall and cell processes Rv0008c NC_002945.3 Mycobrowser_v2 CDS 2089903 2090538 . + 0 Mb1882 ureF Urease accessory protein uref Mb1882, ureF, len: 211 aa. Equivalent to Rv1851,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). ureF, urease accessory protein. Identical to UREF_MYCTU|P50050 from M. tuberculosis. X2BJ66,Q7VET6 No intermediary metabolism and respiration Rv1851 NC_002945.3 Mycobrowser_v2 CDS 396377 397117 . - 0 Mb0337c HYPOTHETICAL PROTEIN Mb0337c, -, len: 246 aa. Equivalent to Rv0330c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Hypothetical unknown protein. Q7U289 No conserved hypotheticals Rv0330c NC_002945.3 Mycobrowser_v2 CDS 1302680 1303120 . + 0 Mb1204 CONSERVED HYPOTHETICAL PROTEIN Mb1204, -, len: 146 aa. Equivalent to Rv1171, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Conserved hypothetical protein, possibly transmembrane protein. Start has been changed since first submission. Q7U0H1 No conserved hypotheticals Rv1171 NC_002945.3 Mycobrowser_v2 CDS 33566 33778 . + 0 Mb0032 possible remnant of a transposase Mb0032, -, len: 70 aa. Equivalent to Rv0031, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 70 aa overlap). Possible remnant of a transposase, showing partial similarity to mycobacterial transposases in a short overlap, e.g. Rv2791c|MTV002_57 (459 aa), FASTA score: (72.2% identity in 36 aa overlap); Rv2885c, Rv2978c, Rv3827c, etc. Q7U2Z6 No insertion seqs and phages Rv0031 NC_002945.3 Mycobrowser_v2 CDS 51812 52681 . - 0 Mb0049c POSSIBLE MEMBRANE PROTEIN Mb0049c, -, len: 289 aa. Equivalent to Rv0048c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 289 aa overlap). Possible membrane protein. Q7U2Y7 No cell wall and cell processes Rv0048c NC_002945.3 Mycobrowser_v2 CDS 1716486 1717052 . + 0 Mb1558 conserved protein Mb1558, -, len: 188 aa. Equivalent to Rv1531, len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 188 aa overlap). Conserved hypothetical protein, similar to Rv0464c|MTV038.08c (190 aa), FASTA scores: E(): 4.8e-10, (30.9% identity in 175 aa overlap). Q7TZX7 No conserved hypotheticals Rv1531 NC_002945.3 Mycobrowser_v2 CDS 1953102 1953314 . + 0 Mb1769 vapb34 possible antitoxin vapb34 Mb1769, -, len: 70 aa. Equivalent to Rv1740, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 70 aa overlap). Conserved hypothetical protein, highly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96913|Rv0623|MTCY20H10.04 (84 aa), (73.5% identity in 68 aa overlap); P71998|Rv1740 (70 aa), and O07770|Rv0608 (81 aa). Q7TZN6 No virulence, detoxification, adaptation Rv1740 NC_002945.3 Mycobrowser_v2 CDS 2524286 2524585 . + 0 Mb2294 CONSERVED HYPOTHETICAL PROTEIN Mb2294, -, len: 99 aa. Equivalent to Rv2271, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein AAK01340.1|AF265275_3 (AF265275) from uncultured organism Pu8 (104 aa) E= 4e-10, (34% identity in 91 aa overlap) X2BKL0 No conserved hypotheticals Rv2271 NC_002945.3 Mycobrowser_v2 CDS 3817453 3818820 . + 0 Mb3479 mycp4 probable membrane-anchored mycosin mycp4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) Mb3479, -, len: 455 aa. Equivalent to Rv3449, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 455 aa overlap). Probable secreted serine protease (EC 3.4.21.-). Similar to hypothetical unknowns or proteases from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK48366|MT3998 SUBTILASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (411 aa), FASTA scores: opt: 747, E(): 3.5e-33,(45.65% identity in 416 aa overlap); O05461|Rv3883c|MTCY15F10.29 HYPOTHETICAL PROTEIN (446 aa),FASTA scores: opt: 747, E(): 3.8e-33, (45.45% identity in 451 aa overlap); O53695|Rv0291|MTV035.19 HYPOTHETICAL PROTEIN (461 aa), FASTA scores: opt: 660, E(): 1.9e-28,(44.0% identity in 457 aa overlap); etc. And similar to hypothetical proteases from Mycobacterium leprae e.g. O33076|MLCB628.04|ML0041 HYPOTHETICAL 45.7 KDA PROTEIN (PROBABLE SECRETED PROTEASE) (446 aa), FASTA scores: opt: 683, E(): 1.1e-29, (43.8% identity in 450 aa overlap); Q9CD36|ML2528 PUTATIVE PROTEASE (475 aa), FASTA scores: opt: 608, E(): 1.3e-25, (43.0% identity in 451 aa overlap); Q9CBV3|ML1538 POSSIBLE PROTEASE (567 aa), FASTA scores: opt: 389, E(): 9.7e-14, (33.8% identity in 562 aa overlap); etc. Also some similarity to other proteases from several organisms e.g. O31788|APRX ALKALINE SERINE PROTEASE from Bacillus subtilis (442 aa), FASTA scores: opt: 296, E(): 8.3e-09, (29.4% identity in 313 aa overlap); O86650|SC3C3.17c PUTATIVE SECRETED SERINE PROTEASE from Streptomyces coelicolor (450 aa), FASTA scores: opt: 279, E(): 7e-08, (33.55% identity in 343 aa overlap); Q9KBJ7|APRX|BH193 INTRACELLULAR ALKALINE SERINE PROTEASE from Bacillus halodurans (444 aa), FASTA scores: opt: 257, E(): 1.1e-06, (28.65% identity in 335 aa overlap); O86642|SC3C3.08 SERINE PROTEASE from Streptomyces coelicolor (413 aa), FASTA scores: opt: 243,E(): 5.7e-06, (38.25% identity in 387 aa overlap); etc. Has putative signal peptide at N-terminus and hydrophobic stretch at C-terminus. Contains three signatures typical of subtilase family: aspartic acid active site (PS00136),histidine active site (PS00137), serine active site (PS00138). Q7TWH3 No intermediary metabolism and respiration Rv3449 NC_002945.3 Mycobrowser_v2 CDS 3935900 3937957 . + 0 Mb3584 fdxB POSSIBLE ELECTRON TRANSFER PROTEIN FDXB Mb3584, fdxB, len: 685 aa. Equivalent to Rv3554,len: 685 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 685 aa overlap). Possible fdxB,two-domain protein, with ferredoxin reductase electron transfer component in C-terminal part (EC 1.-.-.-) and unknown function in N-terminal part. Indeed, N-terminal end is similar to O85832 HYPOTHETICAL 36.1 KDA PROTEIN from Sphingomonas aromaticivorans strain F199 (catabolic plasmid pNL1) (309 aa), FASTA scores: opt: 615, E(): 2.5e-30, (33.1% identity in 311 aa overlap); and P73428|SLL1468 HYPOTHETICAL 36.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (312 aa), FASTA scores: opt: 317, E(): 4.5e-12, (30.2% identity in 268 aa overlap). And C-terminal end is similar to Q9F9U6|PAAE protein involved in aerobic phenylacetate metabolism from Azoarcus evansii (360 aa), FASTA scores: opt: 935, E(): 7e-50, (43.85% identity in 351 aa overlap); CAC44653|PAAE|SCBAC17A6.08 PUTATIVE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Streptomyces coelicolor (368 aa), FASTA scores: opt: 93, E(): 9.5e-50,(41.95% identity in 372 aa overlap); Q9FA57|PACI FERREDOXIN from Azoarcus evansii (360 aa), FASTA scores: opt: 925, E(): 2.9e-49, (43.3% identity in 351 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Escherichia coli strains K12 and W (356 aa), FASTA scores: opt: 910, E(): 2.4e-48, (43.05% identity in 353 aa overlap); Q9APJ6|PAAE ELECTRON TRANSFER PROTEIN (FRAGMENT) from Hyphomicrobium chloromethanicum (241 aa), FASTA scores: opt: 404, E(): 1.7e-17, (35.45% identity in 234 aa overlap); BAB51608|MLL5100 FERREDOXIN from Rhizobium loti (Mesorhizobium loti) (365 aa), FASTA scores: opt: 316,E(): 5.8e-12, (28.95% identity in 349 aa overlap); etc. C-terminus also similar to P96853|Rv3571|MTCY06G11.18 PUTATIVE ELECTRON TRANSFER PROTEIN from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 450, E(): 3.6e-20, (32.95% identity in 358 aa overlap). Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. BELONGS TO THE 2FE2S PLANT-TYPE FERREDOXIN FAMILY. COFACTOR: BINDS A 2FE-2S CLUSTER (BY SIMILARITY). Q7TW80 No intermediary metabolism and respiration Rv3554 NC_002945.3 Mycobrowser_v2 CDS 2523652 2524179 . + 0 Mb2293 lppN Probable lipoprotein lppN Mb2293, lppN, len: 175 aa. Equivalent to Rv2270,len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 175 aa overlap). Probable lppN,lipoprotein; has appropriately positioned prokaryotic membrane lipoprotein attachment site PS00013. X2BK82,Q7VEM3 No cell wall and cell processes Rv2270 NC_002945.3 Mycobrowser_v2 CDS 1561772 1562104 . + 0 Mb1425 rpoZ PROBABLE DNA-DIRECTED RNA POLYMERASE (OMEGA CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE OMEGA SUBUNIT) Mb1425, rpoZ, len: 110 aa. Equivalent to Rv1390,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Probable rpoZ,DNA-directed RNA polymerase omega chain (EC 2.7.7.6). BELONGS TO THE RNA POLYMERASE OMEGA CHAIN FAMILY. X2BHY4,P66722 No information pathways Rv1390 NC_002945.3 Mycobrowser_v2 CDS 3303419 3304279 . - 0 Mb3014c HYPOTHETICAL PROTEIN Mb3014c, -, len: 286 aa. Equivalent to Rv2990c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Hypothetical unknown protein. Q7TXH4 No conserved hypotheticals Rv2990c NC_002945.3 Mycobrowser_v2 CDS 1171487 1172602 . - 0 Mb1077c HYPOTHETICAL PROTEIN Mb1077c, -, len: 371 aa. Equivalent to Rv1048c,len: 371 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 371 aa overlap). Hypothetical unknown protein. Q7U0S8 No conserved hypotheticals Rv1048c NC_002945.3 Mycobrowser_v2 CDS 3323259 3323882 . + 0 Mb3033 HYPOTHETICAL PROTEIN Mb3033, -, len: 207 aa. Equivalent to Rv3008, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Hypothetical unknown protein. Start uncertain. Q7TXG3 No conserved hypotheticals Rv3008 NC_002945.3 Mycobrowser_v2 CDS 477698 478339 . - 0 Mb0404c POSSIBLE SECRETED PROTEIN Mb0404c, -, len: 213 aa. Equivalent to Rv0398c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Possible secreted protein, sharing no homology with other proteins. Has potential signal sequence with hydrophobic stretch from aa 7-25. Q7U232 No cell wall and cell processes Rv0398c NC_002945.3 Mycobrowser_v2 CDS 3624111 3624524 . - 0 Mb3316c usfY PUTATIVE PROTEIN USFY Mb3316c, usfY, len: 137 aa. Equivalent to Rv3288c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). usfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins. P96893 No NC_002945.3 Mycobrowser_v2 CDS 364873 365094 . + 0 Mb0308 vapb2 possible antitoxin vapb2 Mb0308, -, len: 73 aa. Equivalent to Rv0300, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical protein, similar to Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa), FASTA scores: opt: 84, E(): 8.3, (39.5% identity in 38 aa overlap). Q7U2B7 No virulence, detoxification, adaptation Rv0300 NC_002945.3 Mycobrowser_v2 CDS 365091 365516 . + 0 Mb0309 vapc2 possible toxin vapc2 Mb0309, -, len: 141 aa. Equivalent to Rv0301, len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Conserved hypothetical protein, similar to other hypothetical M. tuberculosis proteins e.g. Rv2757c, Rv0229c, Rv2546, etc. Q7U2B6 No virulence, detoxification, adaptation Rv0301 NC_002945.3 Mycobrowser_v2 CDS 262479 263027 . + 0 Mb0225 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0225, -, len: 182 aa. Equivalent to Rv0219, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable conserved transmembrane protein, showing similarity with CAB76992.1|AL159178 putative lipoprotein from Streptomyces coelicolor (163 aa). Q7U2J4 No cell wall and cell processes Rv0219 NC_002945.3 Mycobrowser_v2 CDS 330073 330993 . + 0 Mb0282 CONSERVED HYPOTHETICAL PROTEIN Mb0282, -, len: 306 aa. Equivalent to Rv0276, len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 306 aa overlap). Conserved hypothetical protein, similar to Rv2237|Z70692|MTCY427.18 from Mycobacterium tuberculosis (296 aa), FASTA scores: opt: 874, E(): 0, (49.6% identity in 282 aa overlap). Q7U2E0 No conserved hypotheticals Rv0276 NC_002945.3 Mycobrowser_v2 CDS 457932 458840 . - 0 Mb0388c HYPOTHETICAL PROTEIN Mb0388c, -, len: 302 aa. Equivalent to Rv0381c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Hypothetical unknown protein. Equivalent to AAK44616.1 from Mycobacterium tuberculosis strain CDC1551 (254 aa) but longer 48 aa. Q7U246 No conserved hypotheticals Rv0381c NC_002945.3 Mycobrowser_v2 CDS 2213907 2216222 . - 0 Mb2015c ctpG PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE G CTPG Mb2015c, ctpG, len: 771 aa. Equivalent to Rv1992c,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 771 aa overlap). Probable ctpG, metal cation-transporting P-type ATPase G (transmembrane protein) (EC 3.6.3.-), similar to others, especially cadmium-transporting ATPases (EC 3.6.3.3), e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI PROBABLE CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO PROBABLE CADMIUM-TRANSPORTING ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV PUTATIVE CATION TRANSPORTER P-TYPE ATPASE V (770 aa); Rv1469; Rv0092; etc. Contains PS00435 Peroxidases proximal heme-ligand signature and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. X2BJ77,P63690 No NC_002945.3 Mycobrowser_v2 CDS 2485355 2485531 . - 0 Mb2256B vapB16 Possible antitoxin VapB16 Mb2256B, len: 58 aa. Equivalent to Rv2231B len: 58 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 58 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB16,antitoxin,part of toxin-antitoxin (TA) operon with Rv2231A (See Pandey and Gerdes, 2005). X2BJN5 No virulence, detoxification, adaptation Rv2231B NC_002945.3 Mycobrowser_v2 CDS 843137 843394 . + 0 Mb0769 vapb31 possible antitoxin vapb31 Mb0769, -, len: 85 aa. Equivalent to Rv0748, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, N-terminus similar to N-terminal region of NP_436939.1|NC_003078 HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (75 aa). Also similar to Mycobacterium tuberculosis proteins Rv2871 CONSERVED HYPOTHETICAL PROTEIN (75 aa); Rv1241, Rv2132, Rv3321c,etc. Q7U1D2 No virulence, detoxification, adaptation Rv0748 NC_002945.3 Mycobrowser_v2 CDS 52815 53228 . + 0 Mb0050 CONSERVED HYPOTHETICAL PROTEIN Mb0050, -, len: 137 aa. Equivalent to Rv0049, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein, only equivalent to AL022118|MLCB1913_20 hypothetical protein from Mycobacterium leprae (138 aa), FASTA scores: opt: 768,E(): 0, (83.9% identity in 137 aa overlap). X2BDV4 No conserved hypotheticals Rv0049 NC_002945.3 Mycobrowser_v2 CDS 85218 85607 . - 0 Mb0078c PROBABLE MEMBRANE PROTEIN Mb0078c, -, len: 129 aa. Equivalent to Rv0076c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Probable membrane protein, with membrane-spanning domain at C-terminus. Q7U2W7 No cell wall and cell processes Rv0076c NC_002945.3 Mycobrowser_v2 CDS 843418 843846 . + 0 Mb0770 vapc31 possible toxin vapc31. contains pin domain. Mb0770, -, len: 142 aa. Equivalent to Rv0749, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0749,Rv0277c, Rv2530c, etc. Q7U1D1 No virulence, detoxification, adaptation Rv0749 NC_002945.3 Mycobrowser_v2 CDS 155858 156637 . + 0 Mb0133 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0133, -, len: 259 aa. Equivalent to Rv0128, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Probable conserved transmembrane protein, with some similarity to Rv3064c and other bacterial proteins e.g. AAK85977.1|AE007957|AGR_C_254p from Agrobacterium tumefaciens (206 aa). Q7U2S6 No cell wall and cell processes Rv0128 NC_002945.3 Mycobrowser_v2 CDS 843927 844064 . - 0 Mb0771c HYPOTHETICAL PROTEIN (FRAGMENT) Mb0771c, -, len: 45 aa. Equivalent to Rv0749A, len: 45 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 45 aa overlap). Conserved hypothetical protein (probably gene fragment), similar to part (aa 250-292) of Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 238, E(): 1.9e-13, (79.07% identity in 43 aa overlap). Q7U1D0 No conserved hypotheticals Rv0749A NC_002945.3 Mycobrowser_v2 CDS 844223 844468 . + 0 Mb0772 CONSERVED HYPOTHETICAL PROTEIN Mb0772, -, len: 81 aa. Equivalent to Rv0750, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing almost perfect overlap with C-terminus of Rv0740|MTV041_14 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (175 aa), FASTA scores: (93.8% identity in 81 aa overlap). Possible duplication. Q7U1C9 No conserved hypotheticals Rv0750 NC_002945.3 Mycobrowser_v2 CDS 2507046 2507549 . + 0 Mb2277 Possible secreted unknown protein Mb2277, -, len: 167 aa. Equivalent to Rv2253, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Possible secreted protein; has potential N-terminal signal peptide. Q7VEM9 No cell wall and cell processes Rv2253 NC_002945.3 Mycobrowser_v2 CDS 1776936 1777601 . + 0 Mb1617 PROBABLE TRANSMEMBRANE PROTEIN Mb1617, -, len: 221 aa. Equivalent to Rv1591, len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 221 aa overlap). Probable transmembrane protein, similar to Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical Mycobacterium leprae protein (198 aa), FASTA results: opt: 802, E(): 0, (63.8% identity in 188 aa overlap). X2BID8,P0A5F4 No cell wall and cell processes Rv1591 NC_002945.3 Mycobrowser_v2 CDS 1303128 1304054 . - 0 Mb1205c PE12 pe family protein pe12 Mb1205c, PE12, len: 308 aa. Equivalent to Rv1172c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 308 aa overlap). Member of the Mycobacterium tuberculosis PE family of proteins e.g. P71748|Z81368|MTCY253.25C (361 aa), FASTA scores: opt: 483, E(): 7.8e-22, (46.4% identity in 192 aa overlap). Q7U0H0 No NC_002945.3 Mycobrowser_v2 CDS 1783660 1784418 . + 0 Mb1623 HYPOTHETICAL PROTEIN Mb1623, -, len: 252 aa. Equivalent to Rv1597, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 252 aa overlap). Hypothetical unknown protein. Q7TZW3 No conserved hypotheticals Rv1597 NC_002945.3 Mycobrowser_v2 CDS 2090549 2091223 . + 0 Mb1883 ureG Urease accessory protein ureG Mb1883, ureG, len: 224 aa. Equivalent to Rv1852,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). ureG, urease accessory protein. Identical to UREG_MYCTU|P50051 from M. tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UREG FAMILY. X2BIN9,P0A665 No intermediary metabolism and respiration Rv1852 NC_002945.3 Mycobrowser_v2 CDS 287669 288106 . + 0 Mb0246 vapc24 possible toxin vapc24. contains pin domain. Mb0246, -, len: 145 aa. Equivalent to Rv0240, len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 145 aa overlap). Conserved hypothetical protein, weak similarity with Rv3697c from Mycobacterium tuberculosis (145 aa), FASTA scores: opt: 145, E(): 7.6e-05, (28.0% identity in 143 aa overlap). Q7U2H4 No virulence, detoxification, adaptation Rv0240 NC_002945.3 Mycobrowser_v2 CDS 2129976 2130383 . + 0 Mb1924 conserved protein Mb1924, -, len: 135 aa. Equivalent to Rv1891, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein. Equivalent to MLCB561.09|AL049571 hypothetical protein from Mycobacterium leprae (134 aa),FASTA scores: opt: 800, E(): 0, (79.7% identity in 133 aa overlap). Q7TZC6 No conserved hypotheticals Rv1891 NC_002945.3 Mycobrowser_v2 CDS 300060 300353 . - 0 Mb0256c conserved protein Mb0256c, -, len: 97 aa. Equivalent to Rv0250c, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, equivalent to MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486 hypothetical protein from Mycobacterium leprae (98 aa),FASTA scores: opt: 478, E(): 4.4e-28, (72.6% identity in 95 aa overlap). Also similar to C-terminus of AC44316.1|AL596043|SCBAC31E11.05c hypothetical protein from Streptomyces coelicolor (146 aa). Q7U2G4 No conserved hypotheticals Rv0250c NC_002945.3 Mycobrowser_v2 CDS 1717129 1717563 . - 0 Mb1559c CONSERVED HYPOTHETICAL PROTEIN Mb1559c, -, len: 144 aa. Equivalent to Rv1532c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved hypothetical protein, similar to P20378|YPHR_HALHA Hypothetical 15.6 kd protein from Halobacterium halobium (151 aa), FASTA scores: opt: 152, E():4.5e-05, (30.1% identity in 103 aa overlap). Q7TZX6 No conserved hypotheticals Rv1532c NC_002945.3 Mycobrowser_v2 CDS 1784439 1784849 . - 0 Mb1624c conserved protein Mb1624c, -, len: 136 aa. Equivalent to Rv1598c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Conserved hypothetical protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa). Q7TZW2 No conserved hypotheticals Rv1598c NC_002945.3 Mycobrowser_v2 CDS 2623336 2623653 . + 0 Mb2396 CONSERVED HYPOTHETICAL PROTEIN Mb2396, -, len: 105 aa. Equivalent to Rv2375, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Conserved hypothetical protein, highly similar to only CAC32314|2SCD60.09c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (98 aa), FASTA scores: opt: 425,E(): 5.7e-24, (63.25% identity in 98 aa overlap). Q7TYR0 No conserved hypotheticals Rv2375 NC_002945.3 Mycobrowser_v2 CDS 2351080 2351274 . - 0 Mb2135c pup prokaryotic ubiquitin-like protein pup Mb2135c, -, len: 64 aa. Equivalent to Rv2111c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Conserved hypothetical protein. Highly similar to a hypothetical protein TR:Q53078 (EMBL:U26422) (64 aa) upstream of Rhodococcus proteasome beta-type subunit 1, FASTA scores; opt: 349,E(): 7.3e-25, 84.4% identity in 64 aa overlap X2BK62,Q7TZ12 No intermediary metabolism and respiration Rv2111c NC_002945.3 Mycobrowser_v2 CDS 1215421 1215741 . + 0 Mb1116A CONSERVED HYPOTHETICAL PROTEIN Mb1116A, -, len: 106 aa. Equivalent to Rv1087A,len: 106 aa (fragment), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 106 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of near ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE from Mycobacterium tuberculosis (262 aa), FASTA scores: opt: 200, E(): 1.1e-06, (57.9% identity in 76 aa overlap). Q7U0P6 No cell wall and cell processes Rv1087A NC_002945.3 Mycobrowser_v2 CDS 1443548 1443883 . - 0 Mb1323c CONSERVED HYPOTHETICAL SECRETED PROTEIN Mb1323c, -, len: 111 aa. Equivalent to Rv1291c,len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 111 aa overlap). Conserved hypothetical secreted protein, similar to others in Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU HYPOTHETICAL 11.6 KD PROTEIN (113 aa), FASTA score: opt: 246, E(): 1.7e-09, (40.0% identity in 110 aa overlap); Rv1804c,Rv1810, Rv0622, etc. X2BHW7 No cell wall and cell processes Rv1291c NC_002945.3 Mycobrowser_v2 CDS 2186978 2187568 . - 0 Mb1979c conserved protein Mb1979c, -, len: 196 aa. Equivalent to Rv1944c,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Conserved hypothetical protein, similar to C-terminal part of SCE20.29|AL136058|CAB65585.1 hypothetical protein from Streptomyces coelicolor (338 aa), BLASTP scores,Identities = 37/131 (28%), Positives = 51/131 (38%). Q7TZ88 No conserved hypotheticals Rv1944c NC_002945.3 Mycobrowser_v2 CDS 1405576 1406475 . + 0 Mb1289 udgb probable uracil dna glycosylase, udgb Mb1289, -, len: 299 aa. Equivalent to Rv1259, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 299 aa overlap). Conserved hypothetical protein. Similar to AL109732|SC7H2.04 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 870, E(): 0, (57.1% identity in 231 aa overlap). X2BHG5 No information pathways Rv1259 NC_002945.3 Mycobrowser_v2 CDS 1815436 1815927 . - 0 Mb1654c conserved protein Mb1654c, -, len: 163 aa. Equivalent to Rv1628c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 163 aa overlap). Conserved hypothetical protein, some similarity to others e.g. Q51796 ACAC PROTEIN in Pyrococcus furiosus (136 aa), FASTA scores: opt: 199, E(): 4.6e-06, (34.7% identity in 121 aa overlap). Q7TZV3 No conserved hypotheticals Rv1628c NC_002945.3 Mycobrowser_v2 CDS 2216219 2216491 . - 0 Mb2016c conserved protein Mb2016c, -, len: 90 aa. Equivalent to Rv1993c, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Conserved hypothetical protein, very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). X2BJS9 No conserved hypotheticals Rv1993c NC_002945.3 Mycobrowser_v2 CDS 2375048 2375635 . - 0 Mb2158c conserved protein Mb2158c, -, len: 195 aa. Equivalent to Rv2134c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49789. FASTA best: Q49789 B2126_C3_228, opt: 1192, E( ): 0 (91.1% identity in 192 aa overlap) Q7TZ01 No conserved hypotheticals Rv2134c NC_002945.3 Mycobrowser_v2 CDS 308180 308398 . + 0 Mb0263 CONSERVED HYPOTHETICAL PROTEIN Mb0263, -, len: 72 aa. Equivalent to Rv0257, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Hypothetical protein,orthologue of ML1828A conserved hypothetical protein from Mycobacterium leprae. Replaced Rv0257c (older annotation). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa). Q7U2F8 No conserved hypotheticals Rv0257 NC_002945.3 Mycobrowser_v2 CDS 3673026 3674243 . + 0 Mb3363 dacB1 probable penicillin-binding protein dacb1 (d-alanyl-d-alanine carboxypeptidase) (dd-peptidase) (dd-carboxypeptidase) (pbp) (dd-transpeptidase) (serine-type d-ala-d-ala carboxypeptidase) (d-amino acid hydrolase) Mb3363, dacB1, len: 405 aa. Equivalent to Rv3330,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Probable dacB1,D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), equivalent to Mycobacterium leprae proteins Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (411 aa), FASTA scores: opt: 2066, E(): 2.5e-102, (77.15% identity in 416 aa overlap); Q49917|L308_F1_36 (228 aa), FASTA scores: opt: 1241, E(): 7.9e-59, (78.9% identity in 232 aa overlap) (note that this protein corresponds to C-terminal part of the putative protein encoded by Rv3330, aa 174-405); and Q49921|PBPC (182 aa), FASTA scores: opt: 736, E(): 3.7e-32, (73.95% identity in 169 aa overlap) (note that this protein corresponds to N-terminal part of the putative protein encoded by Rv3330, aa 1-158); note L308_F1_36 (228 aa) and PBPC (182 aa) are two consecutive Mycobacterium leprae ORFs . Also similar to others e.g. Q9FC34|SC4G1.16c PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (413 aa),FASTA scores: opt: 572, E(): 3.4e-23, (33.75% identity in 382 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) from Bacillus subtilis (382 aa), FASTA scores: opt: 422,E(): 2.8e-15, (31.3% identity in 249 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN) from Bacillus halodurans (395 aa), FASTA scores: opt: 421, E(): 3.2e-15, (31.95% identity in 241 aa overlap); etc. Also similar to M. tuberculosis Q10828|Rv2911|MTCY274.43 PROBABLE PENICILLIN-BINDING PROTEIN (BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY) (291 aa), FASTA scores: opt: 746, E(): 1.6e-32,(47.0% identity in 266 aa overlap). Has hydrophobic stretches at both N- and C-termini. Certainly membrane-bound protein. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY. Q7TWP8 No NC_002945.3 Mycobrowser_v2 CDS 932959 933681 . - 0 Mb0859c HYPOTHETICAL PROTEIN Mb0859c, -, len: 240 aa. Equivalent to Rv0836c,len: 217 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 217 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa). Q7U157 No conserved hypotheticals Rv0836c NC_002945.3 Mycobrowser_v2 CDS 2943318 2944094 . + 0 Mb2690 ribD POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) Mb2690, ribD, len: 258 aa. Equivalent to Rv2671,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein incuding diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), highly similar to O05684|MLC1351.23|ML1340 POSSIBLE REDUCTASE from Mycobacterium leprae (268 aa), FASTA scores: opt: 1211,E(): 3e-68, (72.9% identity in 251 aa overlap). Also weakly similar to others e.g. Q9HWX2|RIBD|PA4056 RIBOFLAVIN-SPECIFIC DEAMINASE/REDUCTASE from Pseudomonas aeruginosa (373 aa), FASTA scores: opt: 211, E(): 6.3e-06,(30.1% identity in 216 aa overlap); Q9HQA1|RIBG|VNG1256G RIBOFLAVIN-SPECIFIC DEAMINASE from Halobacterium sp. strain NRC-1 (220 aa), FASTA scores: opt: 202, E(): 1.5e-05, (27.0% identity in 174 aa overlap); O28272|RIB7_ARCFU|AF2007 PUTATIVE 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) (EC 1.1.1.193) from Archaeoglobus fulgidus (219 aa), FASTA scores: opt: 209, E(): 5.4e-06, (24.15% identity in 211 aa overlap); P25539|RIBD_ECOLI|RIBG|B0414 from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 185, E(): 0.00026, (26.7% identity in 221 aa overlap); etc. But also similar to several hydrolases e.g. Q9X825|SC9B1.05 PUTATIVE HYDROLASE from Streptomyces coelicolor (265 aa), FASTA scores: opt: 536, E(): 2.9e-26,(44.25% identity in 235 aa overlap); Q9RKM1|SCD17.10 PUTATIVE BIFUNCTIONAL ENZYME DEAMINASE/REDUCTASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 228,E(): 5.6e-07, (33.5% identity in 188 aa overlap); etc. Equivalent to AAK47060 from Mycobacterium tuberculosis strain CDC1551 (239 aa) but longer 19 aa. SUPPOSED BELONG TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY IN THE N-TERMINAL SECTION; and TO THE HTP REDUCTASE FAMILY IN THE C-TERMINAL SECTION. Q7TY53 No intermediary metabolism and respiration Rv2671 NC_002945.3 Mycobrowser_v2 CDS 400565 401080 . - 0 Mb0342c PE6 pe family protein pe6 Mb0342c, PE6, len: 171 aa. Equivalent to Rv0335c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below); contains short region of similarity to part of the unique N-terminus of the Mycobacterium tuberculosis PGRS family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 219, E(): 1.1e-08, (51.5% identity in 66 aa overlap). Q7U284 No NC_002945.3 Mycobrowser_v2 CDS 2837572 2837817 . - 0 Mb2580c vapb20 possible antitoxin vapb20 Mb2580c, -, len: 81 aa. Equivalent to Rv2550c, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Hypothetical unknown protein. Q7TYB5 No virulence, detoxification, adaptation Rv2550c NC_002945.3 Mycobrowser_v2 CDS 2383021 2383236 . - 0 Mb2166A parD2 Possible antitoxin ParD2 Mb2166A, len: 71 aa. Equivalent to Rv2142A len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible parD2,antitoxin, part of toxin-antitoxin (TA) operon with Rv2142c (See Pandey and Gerdes, 2005). X2BK19 No virulence, detoxification, adaptation Rv2142A NC_002945.3 Mycobrowser_v2 CDS 2426639 2427028 . - 0 Mb2208c CONSERVED HYPOTHETICAL PROTEIN Mb2208c, -, len: 129 aa. Equivalent to Rv2186c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, equivalent to hypothetical Mycobacterium leprae protein ML0888 (135 aa). FASTA scores: ML0888 opt: 704, E(): 2.9e-43; 80.000% identity in 130 aa overlap CAA18694.1| (AL022602). Q7TYY0 No conserved hypotheticals Rv2186c NC_002945.3 Mycobrowser_v2 CDS 990413 993061 . - 0 Mb0914c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR-FAMILY) Mb0914c, -, len: 882 aa. Equivalent to Rv0890c,len: 882 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 882 aa overlap). Probable transcriptional regulatory protein, LuxR family, highly similar (but shorter 238 aa in N-terminus) to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar (generally in part) to others e.g. T50568 probable multi-domain regulatory protein from Streptomyces coelicolor (1334 aa); P10957|NARL_ECOLI nitrate/nitrite response regulator protein from Escherichia coli (216 aa),FASTA scores: opt: 193, E(): 6e-06, (37.4% identity in 99 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. MTCY02B10_22, MTV008_44,MTV036_21, and MTCY31_24. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, and probable helix-turn helix motif from aa 836 to 857 (Score 1559, +4.50 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. X2BGB7,P59969 No regulatory proteins Rv0890c NC_002945.3 Mycobrowser_v2 CDS 1002906 1003169 . - 0 Mb0922c CONSERVED HYPOTHETICAL PROTEIN Mb0922c, -, len: 87 aa. Equivalent to Rv0898c, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 87 aa overlap). Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap). X2BGG5 No conserved hypotheticals Rv0898c NC_002945.3 Mycobrowser_v2 CDS 4152175 4152357 . - 0 Mb3797c PROBABLE REMNANT OF A TRANSPOSASE Mb3797c, -, len: 60 aa. Equivalent to Rv3770A, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 204, E(): 1e-07, (80.5% identity in 41 aa overlap). Continuation of Rv3770B. Q7TVQ3 No insertion seqs and phages Rv3770A NC_002945.3 Mycobrowser_v2 CDS 367197 370640 . - 0 Mb0312c PPE5 ppe family protein ppe5 Mb0312c, PPE5, len: 1147 aa. Equivalent to 3' end of Rv0304c, len: 2204 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1147 aa overlap). Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Z95324|MTY13E10_16 from M. tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from M. tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0,(42.3% identity in 522 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a shorter CDS (Mb0312c) equivalent to the 3' end of Rv0304c/PPE5. Q7U2B3 No NC_002945.3 Mycobrowser_v2 CDS 3077981 3078307 . - 0 Mb2839c PROBABLE TRANSPOSASE Mb2839c, -, len: 108 aa. Equivalent to Rv2815c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Probable transposase,identical from aa 51 with P19772|YIA2_MYCTU PUTATIVE TRANSPOSASE (INSERTION ELEMENT IS986) from Mycobacterium tuberculosis (59 aa), FASTA scores: opt: 365, E(): 1.1e-19, (96.6% identity in 59 aa overlap); and other transposases. X2BLL3,P59801 No insertion seqs and phages Rv2815c NC_002945.3 Mycobrowser_v2 CDS 1172835 1173281 . + 0 Mb1078 PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN Mb1078, -, len: 148 aa. Equivalent to Rv1049, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 148 aa overlap). Probable transcriptional repressor protein, similar to many e.g. P74870 NEGATIVE REGULATOR OF EMR LOCUS EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn -helix motif at aa 58-79 (Score 1495, +4.28 SD). Q7U0S7 No regulatory proteins Rv1049 NC_002945.3 Mycobrowser_v2 CDS 308619 309074 . - 0 Mb0264c CONSERVED HYPOTHETICAL PROTEIN Mb0264c, -, len: 151 aa. Equivalent to Rv0258c,len: 151 aa (alternative start possible), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 151 aa overlap). Conserved hypothetical protein,showing some similarity to Rv1685c|MTCI125_6 from Mycobacterium tuberculosis (207 aa), FASTA scores: E(): 9.3e-07, (32.1% identity in 140 aa overlap). Also some similarity with AL049819|SCE7_13|T36295 probable transcription regulator from Streptomyces coelicolor (204 aa), FASTA scores: opt: 158, E(): 0.00052, (27.0% identity in 111 aa overlap). Q7U2F7 No conserved hypotheticals Rv0258c NC_002945.3 Mycobrowser_v2 CDS 1058113 1058430 . - 0 Mb0973c chorismate mutase Mb0973c, -, len: 105 aa. Equivalent to Rv0948c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 105 aa overlap). Conserved hypothetical protein, equivalent to NP_301237.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (105 aa). Also similar (except in N-terminus) to SCD63.16c|CAB82023.1|AL161755 hypothetical protein from Streptomyces coelicolor (110 aa); and to N-terminus of two chorismate mutase/prephenate dehydratase. X2BGA2,P64768 No intermediary metabolism and respiration Rv0948c NC_002945.3 Mycobrowser_v2 CDS 3831221 3831889 . + 0 Mb3495 CONSERVED HYPOTHETICAL PROTEIN Mb3495, -, len: 222 aa. Equivalent to Rv3466, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(98.2% identity in 222 aa overlap). Conserved hypothetical ORF in REP13E12 repeat, but extending 5' of repeat. Has segment of identity to other REP13E12 ORF's e.g. MTCY336.16, MTCI65.15c, MTCY09F9.19, cMTCY251.14c. Q7TWG5 No insertion seqs and phages Rv3466 NC_002945.3 Mycobrowser_v2 CDS 963300 963581 . + 0 Mb0886 CONSERVED HYPOTHETICAL PROTEIN Mb0886, -, len: 93 aa. Equivalent to Rv0863, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, highly similar to NP_302418.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (74 aa). Also weakly similar in part to U82598|ECU82598_135 HYPOTHETICAL PROTEIN from Escherichia coli, FASTA scores: (32.4% identity in 71 aa overlap); and M74011|YEPYSCOP_8 HYPOTHETICAL PROTEIN from Yersinia enterocolitica (165 aa), FASTA scores: (38.6 identity in 57 aa overlap). Q7U130 No conserved hypotheticals Rv0863 NC_002945.3 Mycobrowser_v2 CDS 1570419 1570820 . - 0 Mb1432c vapc10 possible toxin vapc10 Mb1432c, -, len: 133 aa. Equivalent to Rv1397c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 133 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis protein MTCY159.08C|Rv2548 (125 aa), FASTA scores: E(): 2.3e-14,(42.4% identity in 125 aa overlap). Q7U048 No virulence, detoxification, adaptation Rv1397c NC_002945.3 Mycobrowser_v2 CDS 1570817 1571074 . - 0 Mb1433c vapb10 possible antitoxin vapb10 Mb1433c, -, len: 85 aa. Equivalent to Rv1398c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 85 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis proteins Rv2547|MTCY159.09C (85 aa), FASTA scores: E(): 0.0035,(37.1% identity in 62 aa overlap); Rv0581, Rv2871, Rv1241,etc. X2BHT5,P64836 No virulence, detoxification, adaptation Rv1398c NC_002945.3 Mycobrowser_v2 CDS 172401 173333 . + 0 Mb0151 possible s-adenosylmethionine-dependent methyltransferase Mb0151, -, len: 310 aa. Equivalent to Rv0146, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Conserved hypothetical protein, highly similar to others e.g. AC30975.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (304 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc. X2BE60,Q7U2R2 No lipid metabolism Rv0146 NC_002945.3 Mycobrowser_v2 CDS 1613289 1613714 . - 0 Mb1474c unknown protein Mb1474c, -, len: 141 aa. Equivalent to Rv1439c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 141 aa overlap). Hypothetical unknown protein. Q7U028 No conserved hypotheticals Rv1439c NC_002945.3 Mycobrowser_v2 CDS 1265977 1266318 . + 0 Mb1168 POSSIBLE ENOYL-COA HYDRATASE Mb1168, -, len: 113 aa. Equivalent to Rv1136, len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 113 aa overlap). Probable enoyl-CoA hydratase (possible gene fragment) (EC 5.-.-.-). Some similarity to N-terminus of carnitine racemases and enoyl-CoA hydratases (but much shorter) e.g. I41014 carnitine racemase from Escherichia coli (297 aa), FASTA scores: opt: 258, E(): 2.5e-11, (44.5% identity in 110 aa overlap); and Rv0222 putative enoyl-CoA hydratase from M. tuberculosis (262 aa). Q7U0K3 No lipid metabolism Rv1136 NC_002945.3 Mycobrowser_v2 CDS 464428 467685 . + 0 Mb0393 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR/UHPA-FAMILY) Mb0393, -, len: 1085 aa. Equivalent to Rv0386, len: 1085 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1085 aa overlap). Probable regulatory protein, LuxR/uhpA family, highly similar to CAC30706.1|AL583923 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar in part to other regulatory proteins e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); N-terminus of CAB92369.1|AL356612 putative AfsR-like regulatory protein from Streptomyces coelicolor (1114 aa); N-terminus of NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional regulator from Mesorhizobium loti (952 aa); AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores: opt: 224,E() : 1.1e-06, (26.1% identity in 867 aa overlap); etc. Also similar to many putative Mycobacterium tuberculosis regulatory proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA scores: opt: 3756, E(): 0, (56.7% identity in 1089 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature and probable helix-turn-helix motif at aa 1042-1063 (Score 1025, +2.68 S D). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U243 No regulatory proteins Rv0386 NC_002945.3 Mycobrowser_v2 CDS 1887793 1888695 . + 0 Mb1705 probable integral membrane protein Mb1705, -, len: 300 aa. Equivalent to Rv1678, len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 300 aa overlap). Probable integral membrane protein. Q7TZT2 No cell wall and cell processes Rv1678 NC_002945.3 Mycobrowser_v2 CDS 2939059 2939550 . - 0 Mb2683c CONSERVED HYPOTHETICAL PROTEIN Mb2683c, -, len: 163 aa. Equivalent to Rv2665A,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein; N-terminus highly similar to N-terminus of Rv1046c from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 313, E(): 2.9e-11, (44.7% identity in 159 aa overlap). Alternative to Rv2665. Q7TY58 No Rv2665A NC_002945.3 Mycobrowser_v2 CDS 2893191 2893595 . + 0 Mb2627 vapc40 possible toxin vapc40. contains pin domain. Mb2627, -, len: 134 aa. Equivalent to Rv2596, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Conserved hypothetical protein, only similar to O07780|Rv0598c|MTCY19H5.24 HYPOTHETICAL 14.8 KDA PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA scores: opt: 254, E(): 8.8e-11, (41.55% identity in 130 aa overlap). Q7TY97 No virulence, detoxification, adaptation Rv2596 NC_002945.3 Mycobrowser_v2 CDS 2292044 2294668 . - 0 Mb2077c ppm1 Polyprenol-monophosphomannose synthase Ppm1 Mb2077c, ppm1, len: 874 aa. Equivalent to Rv2051c,len: 874 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 874 aa overlap). ppm1,Polyprenol-monophosphomannose synthase. Transfers mannose from GDP-Mannose to all endogenous polyprenol-phosphates in Mycobacterium tuberculosis, proven experimentally (A. Baulard, Institut Pasteur de Lille: see citation below). Very similar to polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). Two-domain protein similar to products of two adjacent ORFs in Mycobacterium leprae MLCB2052.01 (644 aa), probable membrane protein and MLCB2052.02 (277 aa). First domain (aa 1 - 590) corresponds to membrane protein with similarity to P23930|LNT_ECOLI apolipoprotein n-acyltransferase (512 aa) while second domain (aa 591 -874) is similar to Schizosaccharomyces pombe dolichol monophosphate mannose synthase (236 aa) and to Mycobacterium tuberculosis Rv0539. FASTA scores: Z 98604|MLCB2052_1 (644 aa) opt: 2725 E(): 0 ; 67.7% identity in 601 aa overlap; and Z98604|MLCB2052_2 (277 aa) opt: 1449 E(): 0; 78.9% identity in 275 aa overlap; and gp|AF0078|AF007873_1 Schizosaccharomyces pombe dolichocholmonophosphate mannose synthase (236 aa) opt: 456 E(): 7.8e-19; 34.5% identity in 223 aa overlap and sp|P23930|LNT_ECOLI APOLIPOPROTEIN N-ACYLTRANSFERASE (512 aa) opt: 330 E(): 1.9e-11; 26.9% identity in 539 aa overlap; and polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). CAC15462.1|AJ294477 putative polyprenol-phosphate-mannose synthase 2 (Ppm2): (55% identity in 533 aa overlap). Q7VES1 No NC_002945.3 Mycobrowser_v2 CDS 2893812 2894432 . + 0 Mb2628 PROBABLE MEMBRANE PROTEIN Mb2628, -, len: 206 aa. Equivalent to Rv2597, len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Probable membrane protein. X2BKW7,P65030 No cell wall and cell processes Rv2597 NC_002945.3 Mycobrowser_v2 CDS 567795 568241 . + 0 Mb0487 POSSIBLE CONSERVED SECRETED PROTEIN Mb0487, -, len: 148 aa. Equivalent to Rv0477, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Possible conserved secreted protein, equivalent to CAC31969.1|AL583925 hypothetical protein from Mycobacterium leprae (123 aa). Also similar to G83406|PA1914 conserved hypothetical protein from Pseudomonas aeruginosa (408 aa). Contains possible N-terminal signal sequence. X2BF58 No cell wall and cell processes Rv0477 NC_002945.3 Mycobrowser_v2 CDS 171405 172358 . + 0 Mb0150 possible s-adenosylmethionine-dependent methyltransferase Mb0150, -, len: 317 aa. Equivalent to Rv0145, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Conserved hypothetical protein, highly similar to many e.g. CAC32172.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (310 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc. X2BE73,Q7U2R3 No lipid metabolism Rv0145 NC_002945.3 Mycobrowser_v2 CDS 1953314 1953562 . + 0 Mb1770 vapc34 possible toxin vapc34. contains pin domain. Mb1770, -, len: 82 aa. Equivalent to Rv1741, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 82 aa overlap). Conserved hypothetical protein, very similar in N-terminus to other M. tuberculosis hypothetical proteins e.g. P96914|Rv0624|MTCY20H10.05 (131 aa), (80.4% identity in 56 aa overlap); P71999|Rv1741 (82 aa) and O07769|Rv0609 (133 aa). Q7TZN5 No virulence, detoxification, adaptation Rv1741 NC_002945.3 Mycobrowser_v2 CDS 570951 571475 . - 0 Mb0491c HYPOTHETICAL PROTEIN Mb0491c, -, len: 174 aa. Equivalent to Rv0481c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Hypothetical unknown protein. X2BF55 No conserved hypotheticals Rv0481c NC_002945.3 Mycobrowser_v2 CDS 584526 584855 . - 0 Mb0503c HYPOTHETICAL PROTEIN Mb0503c, -, len: 109 aa. Equivalent to Rv0492A,len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein. GC plot suggests CDS. Q7U1W5 No conserved hypotheticals Rv0492A NC_002945.3 Mycobrowser_v2 CDS 65542 66684 . + 0 Mb0063 celA1 POSSIBLE CELLULASE CELA1 (ENDOGLUCANASE) (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL CELLULASE) Mb0063, celA1, len: 380 aa. Equivalent to Rv0062,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Possible celA1,cellulase (EC 3.2.1.4), similar to many e.g. AB65568.1|AL136058 putative secreted endoglucanase (cellulase) from Streptomyces coelicolor (332 aa); P07984|GUNA_CELFI ENDOGLUCANASE A PRECURSOR from Cellulomonas fimi (449 aa); GUN1_STRHA|P33682 endoglucanase 1 precursor (cellulase) from STREPTOMYCES HALSTEDII (321 aa), FASTA scores: opt: 702, E(): 1. 2e-27,(38.9% identity in 319 aa overlap); etc. SEEMS TO BELONG TO CELLULASE FAMILY B (FAMILY 6 OF GLYCOSYL HYDROLASES). Note that previously known as celA. Q7U2Y0 No NC_002945.3 Mycobrowser_v2 CDS 193816 194301 . + 0 Mb0169 TB18.5 conserved protein tb18.5 Mb0169, TB18.5, len: 161 aa. Equivalent to Rv0164,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). TB18.5, conserved hypothetical protein, equivalent to CAB08818.1|Z95398 HYPOTHETICAL PROTEIN from Mycobacterium leprae (156 aa) FASTA scores: opt: 762, E(): 0, (76.3% identity in 152 aa overlap). Some similarity to Rv2185c, Rv0854, Rv0857 from Mycobacterium tuberculosis. Alternative start codon has been suggested. 3' part corrected since first submission (-24 aa). Q7U2P4 No NC_002945.3 Mycobrowser_v2 CDS 1265685 1265927 . + 0 Mb1167 POSSIBLE ACETYL-COA ACETYLTRANSFERASE (ACETOACETYL-COA THIOLASE) Mb1167, -, len: 80 aa. Equivalent to Rv1135A, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 80 aa overlap). Possible acetyl-CoA acetyltransferase (EC 2.3.1.9) (possible gene fragment),highly similar to other acetyl-CoA acetyltransferases e.g. C-terminal part of Rv3556c|Z92774|MTCY6G11_2|MTCY06G11.03|fadA6 ACETYL-COA ACETYLTRANSFERASE from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 219, E(): 5.7e-09, (63.6% identity in 55 aa overlap). Q7U0K4 No lipid metabolism Rv1135A NC_002945.3 Mycobrowser_v2 CDS 3280 4437 . + 0 Mb0003 recF DNA REPLICATION AND REPAIR PROTEIN RECF (SINGLE-STRAND DNA BINDING PROTEIN) Mb0003, recF, len: 385 aa. Equivalent to Rv0003,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 385 aa overlap). recF, DNA replication and repair protein (see citations below), equivalent to others Mycobacterial DNA replication and repair proteins e.g. NP_301131.1|NC_002677 from Mycobacterium leprae (385 aa); Q9L7L5|RECF_MYCPA from Mycobacterium avium subsp. paratuberculosis (385 aa); P50916|RECF_MYCSM from Mycobacterium smegmatis (384 aa); etc. Also highly similar to others e.g. P36176|RECF_STRCO DNA REPLICATION AND REPAIR PROTEIN from Streptomyces coelicolor (373 aa); NP_440892.1|NC_000911 from Synechocystis sp. strain PCC 6803 (384 aa); NP_469352.1|NC_003212 from Listeria innocua (370 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00617 RecF protein signature 1, and PS00618 RecF protein signature 2. BELONGS TO THE RECF FAMILY. X2BDR1,Q7U314 No information pathways Rv0003 NC_002945.3 Mycobrowser_v2 CDS 222063 222353 . + 0 Mb0196 conserved protein Mb0196, -, len: 96 aa. Equivalent to Rv0190, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Conserved hypothetical protein, highly similar to several hypothetical proteins e.g. SYCSLRA_35|Q55554|SLL0176 hypothetical 18.9 KD protein from Synechocystis (167 aa), FASTA scores: opt: 237, E(): 5.8e-16, (39.4% identity in 94 aa overlap). Also highly similar to Z95398|MLCL622_7|O06070 from Mycobacterium leprae (135 aa), FASTA score: (82.6% identity in 92 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0967,Rv0030, Rv1766 (42.5% identity in 80 aa overlap). Q7U2M0 No conserved hypotheticals Rv0190 NC_002945.3 Mycobrowser_v2 CDS 331033 331461 . - 0 Mb0283c vapc25 possible toxin vapc25. contains pin domain. Mb0283c, -, len: 142 aa. Equivalent to Rv0277c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, highly similar to Rv0749|H70824|2911023|CAA17516.1|AL021958 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (142 aa); and similar to several other hypothetical Mycobacterium tuberculosis proteins: Rv0277c, Rv2530c,etc. Q7U2D9 No virulence, detoxification, adaptation Rv0277c NC_002945.3 Mycobrowser_v2 CDS 84031 85203 . + 0 Mb0077 PROBABLE AMINOTRANSFERASE Mb0077, -, len: 390 aa. Equivalent to Rv0075, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Probable aminotransferase (EC 2.6.1.-), similar to many CLASS-II PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES (MALY/PATB SUBFAMILY) e.g. NP_302217.1|NC_002677 aminotransferase from Mycobacterium leprae (402 aa); PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa), FASTA scores: opt: 684, E(): 5.4e-33, (31.3% identity in 384 aa overlap); etc. Also similar to several cystathionine beta-lyase (beta C-S lyase) e.g. AAK69425.1|AF276227_1|AF276227 from Corynebacterium glutamicum (368 aa); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv2294, Rv0858c,etc. Q7U2W8 No intermediary metabolism and respiration Rv0075 NC_002945.3 Mycobrowser_v2 CDS 1 1524 . + 0 Mb0001 dnaA CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA Mb0001, dnaA, len: 507 aa. Equivalent to Rv0001,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 507 aa overlap). dnaA, chromosomal replication initiator protein (see citations below),equivalent to other Mycobacterial CHROMOSOMAL REPLICATION INITIATOR PROTEINS e.g. P46388|DNAA_MYCLE from Mycobacterium leprae (502 aa); Q9L7L7|DNAA_MYCPA from Mycobacterium paratuberculosis (509 aa); P49990|DNAA_MYCAV from Mycobacterium avium (508 aa); P49992|DNAA_MYCSM from Mycobacterium smegmatis (504 aa); etc. Also highly similar to others except in N-terminus e.g. Q9ZH75|DNAA_STRCH CHROMOSOMAL REPLICATION INITIATOR PROTEIN from Streptomyces chrysomallus (624 aa); Q9ZH76|DNAA_STRRE from Streptomyces reticuli (643 aa); DNAA_ECOLI|P03004|B3702 chromosomal replication initiator protein from Escherichia coli strain K12 (467 aa), FASTA scores: opt: 986, E(): 0,(43.2% identity in 389 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS01008 DnaA protein signature. BELONGS TO THE DNAA FAMILY. Note that the first base of this gene has been taken as base 1 of the Mycobacterium bovis genomic sequence. X2BDR0,P49991 No information pathways Rv0001 NC_002945.3 Mycobrowser_v2 CDS 2052 3260 . + 0 Mb0002 dnaN DNA POLYMERASE III (BETA CHAIN) DNAN (DNA NUCLEOTIDYLTRANSFERASE) Mb0002, dnaN, len: 402 aa. Equivalent to Rv0002,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 402 aa overlap). dnaN, DNA polymerase III (beta chain) (EC 2.7.7.7) (see citations below),equivalent to other Mycobacterial DNA POLYMERASES III BETA CHAIN e.g. NP_301130.1|NC_002677 from Mycobacterium leprae (399 aa); Q9L7L6|DP3B_MYCPA from Mycobacterium avium subsp. paratuberculosis (399 aa); P52851|DP3B_MYCSM from Mycobacterium smegmatis (397 aa); etc. Also highly similar to others e.g. P27903|DP3B_STRCO DNA POLYMERASE III BETA CHAIN from Streptomyces coelicolor (376 aa), FASTA scores: opt: 1189, E(): 0, (52.8% identity in 337 aa overlap); P21174|DP3B_MICLU from Micrococcus luteus (310 aa); P52023|DP3B_SYNP7 from Synechococcus sp. strain PCC 7942 (375 aa); etc. Overlaps and extends CDS in neighbouring cosmid MTCY10H4.01. X2BDQ9,O33914 No information pathways Rv0002 NC_002945.3 Mycobrowser_v2 CDS 82783 84018 . + 0 Mb0076 conserved protein Mb0076, -, len: 411 aa. Equivalent to Rv0074, len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Conserved hypothetical protein, similar to Rv2915c|MTCY338.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and showing some simlarity to various enzymes or hypothetical proteins from other organisms, eg NP_243801.1|NC_002570 aryldialkylphosphatase from Bacillus halodurans (394 aa); NP_421471.1|NC_002696 putativ Xaa-Pro dipeptidase from Caulobacter crescentus (429 aa); NP_343436.1|NC_002754 Prolidase (Xaa-Pro dipeptidase) (pepQ-like2) from Sulfolobus solfataricus (408 aa); Q50432|M91040 ORGANO PHOSPHATE ACID ANHYDRASE OPAB from MYCOBACTERIUM SP. (409 aa), FASTA scores: opt: 166, E(): 3.9e-11, (31.2% identity in 430 aa overlap); etc. Q7U2W9 No conserved hypotheticals Rv0074 NC_002945.3 Mycobrowser_v2 CDS 4434 4997 . + 0 Mb0004 CONSERVED HYPOTHETICAL PROTEIN Mb0004, -, len: 187 aa. Equivalent to Rv0004, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Conserved hypothetical protein (see citation below), highly similar, but longer 21 aa in N-terminus, to AAF33696.1|AF222789 unknown protein from Mycobacterium avium subsp. paratuberculosis (166 aa); and highly similar to NP_301132.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (189 aa); S70990 hypothetical protein from Mycobacterium smegmatis (194 aa). Also similar to in C-terminus to C-terminal part of P35925|YREG_STRCO HYPOTHETICAL 19.8 KDA PROTEIN (IN RECF-GYRB INTERGENIC REGION) from Streptomyces coelicolor (190 aa), FASTA scores: opt: 404, E(): 3.9e-18,(40.7% identity in 189 aa overlap). X2BDR3 No conserved hypotheticals Rv0004 NC_002945.3 Mycobrowser_v2 CDS 85671 86501 . - 0 Mb0079c PROBABLE OXIDOREDUCTASE Mb0079c, -, len: 276 aa. Equivalent to Rv0077c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Possible oxidoreductase (EC 1.-.-.-), weakly similar to others e.g. CAC44600.1|AL596162 putative oxidoreductase from Streptomyces coelicolor (275 aa); P33912|BPA1_STRAU NON-HAEM BROMOPEROXIDASE BPO-A1 (BROMIDE PEROXIDASE) (EC 1.11.1.-) from Streptomyces aureofaciens (275 aa); BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 230, E(): 1.5e-07, (26.1% identity in 249 aa overlap); etc. Also similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium tuberculosis. And shows some similarity in part with AAL17935.1|AY054120 putative epoxide hydrolase from Mycobacterium smegmatis (203 aa). Q7U2W6 No intermediary metabolism and respiration Rv0077c NC_002945.3 Mycobrowser_v2 CDS 5123 7267 . + 0 Mb0005 gyrB DNA GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE) Mb0005, gyrB, len: 714 aa. Equivalent to Rv0005,len: 714 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 714 aa overlap). gyrB, DNA gyrase subunit B (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT B e.g. T10005 from Mycobacterium leprae (697 aa); Q9L7L3|GYRB_MYCPA from Mycobacterium avium subsp. paratuberculosis (677 aa) (has its N-terminus shorter); P48355|GYRB_MYCSM from Mycobacterium smegmatis (675 aa); etc. Also highly similar to others e.g. T10969 from Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH from Streptomyces spheroides (684 aa); etc. Contains PS00177 DNA topoisomerase II signature. BELONGS TO THE TYPE II TOPOISOMERASE FAMILY. Q7U312 No information pathways Rv0005 NC_002945.3 Mycobrowser_v2 tRNA 4153159 4153231 . - 0 argU argU tRNA-Arg argU, len: 73 nt. Equivalent to argU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon acg. No NC_002945.3 Mycobrowser_v2 CDS 7302 9818 . + 0 Mb0006 gyrA DNA GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE) Mb0006, gyrA, len: 838 aa. Equivalent to Rv0006,len: 838 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 838 aa overlap). gyrA, DNA gyrase subunit A (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from Mycobacterium leprae (1273 aa); P48354|GYRA_MYCSM from Mycobacterium smegmatis (842 aa); etc. Also highly similar to others e.g. P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from Streptomyces coelicolor (864 aa); NP_346654.1|NC_003030 from Clostridium acetobutylicum (830 aa); NP_387888.1|NC_000964 from Bacillus subtilis (821 aa); etc. Contains PS00018 EF-hand calcium-binding domain. Q7U311 No information pathways Rv0006 NC_002945.3 Mycobrowser_v2 CDS 9914 10828 . + 0 Mb0007 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0007, -, len: 304 aa. Equivalent to Rv0007, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Possible conserved membrane protein, highly similar to Z70722|MLCB1770_7 from Mycobacterium leprae (303 aa), FASTA scores: opt: 812,E(): 1.6e-25, (54.2% identity in 319 aa overlap). C-terminal part highly similar to C-terminus of CAB92992.1|AL357152 putative integral membrane protein from Streptomyces coelicolor (185 aa); and N-terminal part highly similar to C-terminus of NP_302684.1|NC_002677 hypothetical protein from Mycobacterium leprae (123 aa). Q7U310 No cell wall and cell processes Rv0007 NC_002945.3 Mycobrowser_v2 tRNA 10887 10960 . + 0 ileT ileT tRNA-Ile ileT, len: 74 nt. Equivalent to ileT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Ile, anticodon gat. No NC_002945.3 Mycobrowser_v2 CDS 17466 18761 . - 0 Mb0015c pknA TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE A PKNA (PROTEIN KINASE A) (STPK A) Mb0015c, pknA, len: 431 aa. Equivalent to Rv0015c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). pknA, transmembrane serine/threonine-protein kinase (EC 2.7.1.-),magnesium/manganese dependent (see citations below),equivalent to MLCB1770_10|NP_301143.1|NC_002677 putative serine/threonine protein kinase from Mycobacterium leprae (437 aa), FASTA scores: opt: 1883, E(): 0, (72.1% identity in 434 aa overlap). And also highly similar to other kinases from Mycobacterium leprae e.g. MLCB1770_10 from Mycobacterium leprae (437 aa). Also similar to PKNA_MYCLE protein kinase (253 aa), FASTA scores: opt: 1525, E(): 0,(95.0% identity in 242 aa overlap); etc. Also highly similar in part to others e.g. N-terminus of NP_243370.1|NC_002570 from Bacillus halodurans (664 aa); N-terminus of T36717 from Streptomyces coelicolor (673 aa); etc. Also similar to others from Mycobacterium tuberculosis: MTCY10H4_15, MTV021_9, MTCY28_5,MTCY4C12_28, MTCY50_16, MTCY8D9_8, MTCY49_28, MTCY4C12_30,MTCY28_9, etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. It has been shown that sodium orthovanadate inhibits the activity of the enzyme in vitro. X2BDS0,P65727 No NC_002945.3 Mycobrowser_v2 CDS 12468 13016 . + 0 Mb0009 ppiA PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A) Mb0009, ppiA, len: 182 aa. Equivalent to Rv0009,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable ppiA (alternate gene name: cfp22), iron-regulated peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8),equivalent to NP_301138.1|NC_002677 putative peptidyl-prolyl cis-trans isomerase from Mycobacterium leprae (182 aa), FASTA score: (90.1% identity in 182 aa overlap). Also highly similar to others e.g. T36725 from Streptomyces coelicolor (177 aa); T43805 from Halobacterium salinarum (180 aa); NP_219383.1|NC_000919 from Treponema pallidum (215 aa); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY. Alternative start codon has been suggested. X2BDS2,P65763 No information pathways Rv0009 NC_002945.3 Mycobrowser_v2 CDS 13222 13557 . - 0 Mb0010c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0010c, -, len: 111 aa. Equivalent to Rv0010c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Probable conserved membrane protein, equivalent to NP_301139.1|NC_002677 putative membrane protein from Mycobacterium leprae (137 aa); and similar to Rv1417|P71686|YE17_MYCTU HYPOTHETICAL 16.4 KD PROTEIN from Mycobacterium tuberculosis (154 aa),FASTA scores: opt: 121, E(): 0.097, (29.6% identity in 81 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa). Q7U309 No cell wall and cell processes Rv0010c NC_002945.3 Mycobrowser_v2 CDS 13713 13994 . - 0 Mb0011c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0011c, -, len: 93 aa. Equivalent to Rv0011c, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable conserved transmembrane protein, equivalent to NP_301140.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (93 aa); and similar to AL079308|SCH69_24 hypothetical protein from Streptomyces coelicolor (84 aa), FASTA scores: opt: 135, E(): 0.0068, (32.6% identity in 92 aa overlap). X2BDR8,P67377 No cell wall and cell processes Rv0011c NC_002945.3 Mycobrowser_v2 CDS 58182 58472 . + 0 Mb0054 rpsF 30s ribosomal protein s6 rpsf Mb0054, rpsF, len: 96 aa. Equivalent to Rv0053,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Probable 30S ribosomal protein S6, equivalent to RS6_MYCLE|P46389 30s ribosomal protein s6 from Mycobacterium leprae (96 aa), FASTA scores: opt: 570, E(): 1.1e-36, (91.7% identity in 96 aa overlap).Also highly similar to many e.g. Q9X8U2|RS6_STRCO 30S RIBOSOMAL PROTEIN S6 from Streptomyces coelicolor (96 aa); etc. Note that the putative product of this CDS corresponds to spot 6_26 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). Contains PS01048 Ribosomal protein S6 signature. BELONGS TO THE S6P FAMILY OF RIBOSOMAL PROTEINS. X2BDX0,P66592 No information pathways Rv0053 NC_002945.3 Mycobrowser_v2 CDS 59399 59857 . + 0 Mb0057 rplI 50s ribosomal protein l9 rpli Mb0057, rplI, len: 152 aa. Equivalent to Rv0056,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Probable rplI, 50S ribosomal protein L9, equivalent to RL9_MYCLE|P46385 50s ribosomal protein l9 from Mycobacterium leprae (152 aa),FASTA scores: opt: 847, E(): 0, (88.7% identity in 150 aa overlap). Also highly similar to others e.g. Q9X8U5|RL9_STRCO 50S RIBOSOMAL PROTEIN L9 from Streptomyces coelicolor (148 aa); etc. Contains PS00651 Ribosomal protein L9 signature. BELONGS TO THE L9P FAMILY OF RIBOSOMAL PROTEINS. X2BDW5,P66316 No information pathways Rv0056 NC_002945.3 Mycobrowser_v2 CDS 14088 14876 . + 0 Mb0012 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0012, -, len: 262 aa. Equivalent to Rv0012, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv (99.2% identity in 262 aa overlap). Probable conserved membrane protein, similar to AL079308|SCH69_23|T36722 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 506, E(): 1.9e-25, (39.8% identity in 236 aa overlap). Some similarity to BLU0|1958_35A2 DIVIB (fragment) (188 aa), FASTA scores: opt: 204, E(): 8.9e-07, (35.6% identity in 90 aa overlap); and G1129091|DDS cell division and sporulation protein from Bacillus subtilis (231 aa), FASTA scores: opt: 180, E(): 3.8e-05, (30.7% identity in 101 aa overlap). Also similar to Rv1823|MTCY1A11_20 from Mycobacterium tuberculosis FASTA score: (30.1% identity in 246 aa overlap); and MTCY1A11_18 FASTA score: (25.5% identity in 235 aa overlap). Contains probable N-terminal signal sequence. Q7U308 No cell wall and cell processes Rv0012 NC_002945.3 Mycobrowser_v2 CDS 14913 15611 . + 0 Mb0013 trpG POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE) Mb0013, trpG, len: 232 aa. Equivalent to Rv0013,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 232 aa overlap). Possible trpG,anthranilate synthase component II (glutamine amidotransferase) (EC 4.1.3.27), equivalent to NP_301141.1|NC_002677 putative p-aminobenzoate synthase glutamine amidotransferase from Mycobacterium leprae (232 aa). Also highly similar to others e.g. P26922|TRPG_AZOBR Anthranilate synthase component II from Azospirillum brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40,(56.7% identity in 187 aa overlap); T36720 probable glutamine amidotransferase from Streptomyces coelicolor (212 aa); T44524 anthranilate synthase from Nitrosomonas europaea (199 aa); etc. Also similar to E235740 para-aminobenzoate synthase (232 aa), FASTA scores: opt: 1273, E(): 0, (79.7% identity in 232 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site; and PS00442 Glutamine amidotransferases class-I active site. SIMILARITY TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAINS. Note that previously known as pabA. Q7U307 No intermediary metabolism and respiration Rv0013 NC_002945.3 Mycobrowser_v2 CDS 27576 28346 . + 0 Mb0023 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0023, -, len: 256 aa. Equivalent to Rv0023, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible transcriptional regulator, equivalent to CAB96432.1|AJ251434 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (146 aa). N-terminus showing similarity with other transcriptional regulators e.g. AE0002|ECAE000240_9 from Escherichia coli strain K12 (178 aa), FASTA scores: opt: 149, E(): 0.0048,(33.3% identity in 84 aa overlap); etc. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). X2BDT3,P67705 No regulatory proteins Rv0023 NC_002945.3 Mycobrowser_v2 CDS 15589 17469 . - 0 Mb0014c pknB TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B PKNB (PROTEIN KINASE B) (STPK B) Mb0014c, pknB, len: 626 aa. Equivalent to Rv0014c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 626 aa overlap). pknB, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to MLCB1770_9|T10009 probable serine/threonine-specific protein kinase from Mycobacterium leprae (622 aa), FASTA scores: opt: 3600,E(): 0, (86.4% identity in 626 aa overlap). Also similar (highly similar in N-terminus) to others e.g. T36717 from Streptomyces coelicolor (673 aa); NP_389459.1|NC_000964 from Bacillus subtilis (648 aa); NP_465345.1|NC_003210 from Listeria monocytogenes (655 aa); E235741 protein kinase pknB (315 aa), FASTA scores: opt: 1839, E(): 0,(90.8 identity in 305 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature, and PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on serine/threonine residues. X2BDS6,P0A5S5 No NC_002945.3 Mycobrowser_v2 CDS 36851 37246 . + 0 Mb0035 CONSERVED HYPOTHETICAL PROTEIN Mb0035, -, len: 131 aa. Equivalent to Rv0034, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing weak similarity to AE001980|AE001980_7 hypothetical protein from Deinococcus radiodurans (120 aa), FASTA scores: opt: 141, E(): 0.0028,(29.3% identity in 123 aa overlap). X2BDT9 No conserved hypotheticals Rv0034 NC_002945.3 Mycobrowser_v2 CDS 383520 383906 . + 0 Mb0321 conserved protein Mb0321, -, len: 128 aa. Equivalent to Rv0313, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, equivalent only to CAC32049.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (130 aa). TBparse score is 0.877. Q7U2A4 No conserved hypotheticals Rv0313 NC_002945.3 Mycobrowser_v2 CDS 4344746 4344889 . - 0 Mb3955c rpmH 50S RIBOSOMAL PROTEIN L34 RPMH Mb3955c, rpmH, len: 47 aa. Equivalent to Rv3924c,len: 47 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 47 aa overlap). rpmH, 50s ribosomal protein l34 (see citations below), equivalent to many mycobacterial 50S RIBOSOMAL PROTEIN L34 e.g. P46386|RL34_MYCLE|RPMH|ML2713 from Mycobacterium leprae (47 aa), FASTA scores: opt: 287, E(): 8.5e-17, (91.5% identity in 47 aa overlap); and Q9L7L8|RL34_MYCPA|RPMH from M. paratuberculosis (47 aa), FASTA scores: opt: 281,E(): 2.6e-16, (89.35% identity in 47 aa overlap). Also highly similar to other ribosomal proteins e.g. P27901|RL34_STRCO|RPMH|STH24.02 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 234, E(): 1.4e-12,(79.05% identity in 43 aa overlap); and P05647|RL34_BACSU|RPMH from Bacillus subtilis (44 aa) FASTA scores: opt: 229, E(): 3.7e-12, (72.35% identity in 47 aa overlap); etc. Contains PS00784 Ribosomal protein L34 signature. BELONGS TO THE L34P FAMILY OF RIBOSOMAL PROTEINS. X2BPR0,P0A5W5 No NC_002945.3 Mycobrowser_v2 CDS 18758 20233 . - 0 Mb0016c pbpA PROBABLE PENICILLIN-BINDING PROTEIN PBPA Mb0016c, pbpA, len: 491 aa. Equivalent to Rv0016c,len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 491 aa overlap). Probable pbpA,penicillin-binding protein, equivalent to NP_301144.1|NC_002677 putative penicillin-binding protein from Mycobacterium leprae (492 aa); and highly similar to MLCB1770_1 penicillin binding protein from Mycobacterium leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4% identity in 472 aa overlap). Also similar to others e.g. T36716 from Streptomyces coelicolor (490 aa); AAF61246.1|AF241575|PbpA from Streptomyces griseus (485 aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum (482 aa); E235825|pbpA penicillin binding protein (325 aa), FASTA scores: opt: 1618, E(): 0, (78.3% identity in 323 aa overlap); etc. And also similar to MTCY270_5 and MTV003_8 from Mycobacterium tuberculosis. Q7U306 No NC_002945.3 Mycobrowser_v2 CDS 20230 21639 . - 0 Mb0017c rodA PROBABLE CELL DIVISION PROTEIN RODA Mb0017c, rodA, len: 469 aa. Equivalent to Rv0017c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein, equivalent to MLCB1770_12|T10012 probable cell division protein from Mycobacterium leprae (465 aa), FASTA scores: opt: 2475,E(): 0, (81.9% identity in 469 aa overlap). Also highly similar to others e.g. T36715|SCH69.16 from Streptomyces coelicolor (479 aa); NP_243432.1|NC_002570 from Bacillus halodurans (366 aa); NP_347145.1|NC_003030 from Clostridium acetobutylicum (400 aa); etc. Also similar to MTCY270_14 from Mycobacterium tuberculosis FASTA score: (32.2% identity in 369 aa overlap). BELONGS TO THE FTSW/RODA/SPOVE FAMILY. X2BDS4,P63761 No NC_002945.3 Mycobrowser_v2 CDS 21636 23180 . - 0 Mb0018c pstp phosphoserine/threonine phosphatase pstp Mb0018c, ppp, len: 514 aa. Equivalent to Rv0018c,len: 514 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 514 aa overlap). Possible ppp,serine/threonine phosphatase (EC 3.1.3.16), equivalent to MLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASE from Mycobacterium leprae (509 aa), FASTA scores: opt: 2517, E(): 0. Also highly similar to others e.g. T36714 probable protein phosphatase from Streptomyces coelicolor (515 aa); CAA10712.1|AJ132604 pppL protein from Lactococcus lactis (258 aa); NP_248765.1|NC_002516 probable phosphoprotein phosphatase from Pseudomonas aeruginosa (242 aa); etc. Also similar to BSUB0009_46 YLOO PROTEIN from Bacillus subtilis (254 aa), FASTA score: (34.0% identity in 250 aa overlap). Q7U305 No NC_002945.3 Mycobrowser_v2 CDS 96962 97636 . + 0 Mb0091 possible polyketide cyclase/dehydrase Mb0091, -, len: 224 aa. Equivalent to Rv0088, len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Hypothetical unknown protein. X2BDZ8 No lipid metabolism Rv0088 NC_002945.3 Mycobrowser_v2 CDS 23269 23736 . - 0 Mb0019c fhab conserved protein with fha domain, fhab Mb0019c, -, len: 155 aa. Equivalent to Rv0019c,len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 155 aa overlap). Conserved hypothetical protein, equivalent to MLCB1770_14|NP_301147.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (155 aa), FASTA scores: opt: 902, E(): 0, (91.0% identity in 155 aa overlap). Also highly similar to T36713|AL079308|SCH69_14 from Streptomyces coelicolor (172 aa), FASTA scores: opt: 389,E(): 6e-21, (46.2% identity in 171 aa overlap); and similar in C-terminus to others e.g. NP_342559.1|NC_002754 Conserved hypothetical protein from Sulfolobus solfataricus (209 aa); etc. C-terminus also highly similar to C-terminal part of AAF07901.1|AF173844_2|AF173844 putative signal transduction protein GarA from Mycobacterium smegmatis (158 aa). Also similar to Rv1827|MTCY 1A11.16c from Mycobacterium tuberculosis ( 162 aa), FASTA score: (41.2% identity in 85 aa overlap); MTMOAIS_3; MAU66560_1 and MLCB1788_15. Q7U304 No regulatory proteins Rv0019c NC_002945.3 Mycobrowser_v2 CDS 23860 25425 . - 0 Mb0020c fhaa conserved protein with fha domain, fhaa Mb0020c, TB39.8, len: 521 aa. Equivalent to Rv0020c, len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 527 aa overlap). TB39.8,conserved hypothetical protein, identified by proteomic study by the Statens Serum Institute, Denmark (spot TB39.8) (see citation below). Highly similar to NP_301148.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (488 aa); and Z70722|MLCB1770_15|T10015 hypothetical protein from Mycobacterium leprae (463 aa), FASTA scores: opt: 1213,E(): 2.2e-32, (72.3% identity in 506 aa overlap). Alternative start codon in position 24979 has been suggested. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 18 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (521 aa versus 527 aa). Q7U303 No regulatory proteins Rv0020c NC_002945.3 Mycobrowser_v2 CDS 59886 60407 . + 0 Mb0058 HYPOTHETICAL PROTEIN Mb0058, -, len: 173 aa. Equivalent to Rv0057, len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 173 aa overlap). Hypothetical unknown protein. X2BDW3 No conserved hypotheticals Rv0057 NC_002945.3 Mycobrowser_v2 CDS 25894 26862 . - 0 Mb0021c CONSERVED HYPOTHETICAL PROTEIN Mb0021c, -, len: 322 aa. Equivalent to Rv0021c,len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 322 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. NP_464341.1|NC_003210 protein similar to oxidoreductases from Listeria monocytogenes (309 aa); NP_357973.1|NC_003098 Enoyl-acyl carrier protein(ACP) reductase from Streptococcus pneumoniae (324 aa); 2NPD_NEUCR|G726338 2-nitropropane dioxygenase precursor from Neurospora crassa (378 aa), FASTA scores: opt: 383,E(): 1.1e-16, (32.2% identity in 348 aa overlap); etc. Also similar to AE001747_25 from Thermotoga maritima section 59 (314 aa), FASTA scores: opt: 442, E(): 1.5e-19,(30.5% identity in 325 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv3553 (355 aa), FASTA scores: E(): 6.8e-15, (35.3 identity in 235 aa overlap); and Rv1533 (375 aa), FASTA scores: E(): 4.7e-12,(34.4% identity in 262 aa overlap). Q7U302 No conserved hypotheticals Rv0021c NC_002945.3 Mycobrowser_v2 CDS 41988 42335 . - 0 Mb0040c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0040c, -, len: 115 aa. Equivalent to Rv0039c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 115 aa overlap). Possible conserved transmembrane protein, highly similar to NP_301154.1|NC_002677|Z70722|MLCB1770_18 hypothetical protein from Mycobacterium leprae (113 aa), FASTA scores: opt: 492, E(): 7.8e-27, (64.9% identity in 114 aa overlap). Q7U2Z2 No cell wall and cell processes Rv0039c NC_002945.3 Mycobrowser_v2 CDS 102850 103698 . - 0 Mb0096c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0096c, -, len: 282 aa. Equivalent to Rv0093c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Probable conserved membrane protein, equivalent only to CAC30943.1|AL583924 probable integral membrane protein from Mycobacterium leprae (237 aa). Q7U2V4 No cell wall and cell processes Rv0093c NC_002945.3 Mycobrowser_v2 CDS 27004 27423 . - 0 Mb0022c whiB5 probable transcriptional regulatory protein whib-like whib5 Mb0022c, whiB5, len: 139 aa. Equivalent to Rv0022c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable whiB5,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Shows some similarity to O88103|AJ239086|SCO239086_1|WHID|SC6G4.45c|WBLB WHID PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 125, E(): 0.055, (37.1% identity in 97 aa overlap); and slight similarity to G466960|WHIB WHIB PROTEIN (102 aa), FASTA scores: opt: 112, E(): 0.14, (34.3 identity in 67 aa overlap). Q7U301 No NC_002945.3 Mycobrowser_v2 CDS 33208 33537 . + 0 Mb0031 conserved hypothetical protein Mb0031, -, len: 109 aa. Equivalent to Rv0030, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein. X2BDT4 No conserved hypotheticals Rv0030 NC_002945.3 Mycobrowser_v2 CDS 28343 29176 . + 0 Mb0024 PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN [FIRST PART] Mb0024, -, len: 277 aa. Equivalent to 5' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 192 aa overlap). Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477,Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts, Mb0024 and Mb0025. Q7U300 No NC_002945.3 Mycobrowser_v2 CDS 28918 29187 . + 0 Mb0025 PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN [SECOND PART] Mb0025, -, len: 89 aa. Equivalent to 3' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 aa overlap). Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08,(37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts,Mb0024 and Mb0025. No NC_002945.3 Mycobrowser_v2 CDS 29225 29587 . + 0 Mb0026 CONSERVED HYPOTHETICAL PROTEIN Mb0026, -, len: 120 aa. Equivalent to Rv0025, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 120 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 aa), FASTA score: (37.6% identity in 101 aa overlap), and Rv0026 FASTA score: (35.4% identity in 113 aa overlap); etc. Q7U2Z9 No conserved hypotheticals Rv0025 NC_002945.3 Mycobrowser_v2 CDS 36591 36854 . + 0 Mb0034 acpA PROBABLE ACYL CARRIER PROTEIN ACPA (ACP) Mb0034, acpA, len: 87 aa. Equivalent to Rv0033,len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Probable acpA (alternate gene name: acpP), acyl carrier protein, similar to others e.g. ACP_BACSU|P80643 acyl carrier protein (acp) from Bacillus subtilis (77 aa), FASTA scores: opt: 149,E(): 0.00026, (41.4% identity in 70 aa overlap); NP_224500.1|NC_000922 Acyl Carrier Protein from Chlamydophila pneumoniae (79 aa); NP_228471.1|NC_000853 acyl carrier protein from Thermotoga maritima (81 aa); etc. Also similar to proteins of Mycobacterium tuberculosis Rv1344 and Rv2244 (31.5% identity in 73 aa overlap). Q7U2Z4 No lipid metabolism Rv0033 NC_002945.3 Mycobrowser_v2 CDS 59112 59366 . + 0 Mb0056 rpsR1 30s ribosomal protein s18-1 rpsr1 Mb0056, rpsR1, len: 84 aa. Equivalent to Rv0055,len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Probable rpsR1, 30S ribosomal protein S18-1, equivalent to NP_302711.1|NC_002677|O53125|RS18_MYCLE 30S RIBOSOMAL PROTEIN from Mycobacterium leprae (84 aa). Also highly similar to others e.g. Q9X8U4|R18A_STRCO 30S RIBOSOMAL PROTEIN S18-1 from Streptomyces coelicolor (78 aa); RS18_B|ACST|P10806 30s ribosomal protein s18 (bs21) (77 aa), FASTA scores: opt: 220, E(): 4e-10, (52.2% identity in 67 aa overlap); etc. Also similar to MTCY63A_5 from Mycobacterium tuberculosis. BELONGS TO THE S18P FAMILY OF RIBOSOMAL PROTEINS. Note that previously known as rpsR. X2BDW2,P69231 No information pathways Rv0055 NC_002945.3 Mycobrowser_v2 CDS 29702 31135 . + 0 Mb0027 CONSERVED HYPOTHETICAL PROTEIN Mb0027, -, len: 477 aa. Equivalent to 5' end of Rv0026, len: 448 aa, from Mycobacterium tuberculosis strain H37Rv, (94.4% identity in 449 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis: Rv0025 FASTA score: (35.4% identity in 113 aa overlap) and Rv0739 (268 aa), FASTA score: (32.4% identity in 142 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 4 bp insertion (*-atcg) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Q7U2Z8 No NC_002945.3 Mycobrowser_v2 CDS 31173 31490 . + 0 Mb0028 conserved hypothetical protein Mb0028, -, len: 105 aa. Equivalent to Rv0027, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Hypothetical unknown protein. X2BDT8 No conserved hypotheticals Rv0027 NC_002945.3 Mycobrowser_v2 CDS 31498 31803 . + 0 Mb0029 conserved hypothetical protein Mb0029, -, len: 101 aa. Equivalent to Rv0028, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Hypothetical unknown protein. X2BDU3 No conserved hypotheticals Rv0028 NC_002945.3 Mycobrowser_v2 CDS 32041 33138 . + 0 Mb0030 CONSERVED HYPOTHETICAL PROTEIN Mb0030, -, len: 365 aa. Equivalent to Rv0029, len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 365 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. C-terminal region of Rv2082|MTCY49_21|E247006 hypothetical 73.6 kDa protein (721 aa), FASTA scores: opt: 453, E(): 1.2e-22, (38.5% identity in 265 aa overlap); Rv3899c|MTY15F10_12 HYPOTHETICAL 40.8 KD PROTEIN (410 aa), FASTA score: (33.7% identity in 252 aa overlap); etc. Q7U2Z7 No conserved hypotheticals Rv0029 NC_002945.3 Mycobrowser_v2 CDS 34279 36594 . + 0 Mb0033 bioF2 POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE) Mb0033, bioF2, len: 771 aa. Equivalent to Rv0032,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 771 aa overlap). Probable bioF2,8-amino-7-oxononanoate synthase (EC 2.3.1.47), with its C-terminal similar to others e.g. BIOF_BACSU|P53556 8-amino-7-oxononanoate synthase from Bacillus subtilis (389 aa), FASTA scores: opt: 775, E(): 0, (37.9% identity in 346 aa overlap); P22806|BIOF_BACSH from Bacillus sphaericus (389 aa); etc. Also similar to BIOF1|Rv1569|MTCY336_35 from Mycobacterium tuberculosis (386 aa), AF041819_4 from Mycobacterium bovis, and BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Q7U2Z5 No NC_002945.3 Mycobrowser_v2 CDS 37243 38931 . + 0 Mb0036 fadD34 PROBABLE FATTY-ACID-COA LIGASE FADD34 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0036, fadD34, len: 562 aa. Equivalent to Rv0035,len: 562 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 562 aa overlap). Probable fadD34,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. MBU75685_1 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 408, E(): 8.2e-20; etc. Also similar to G1171128 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa),FASTA scores: opt: 445, E(): 1.3e-21, (28.1% identity in 573 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. MTCY02B10.09, FASTA score: (32.3% identity in 468 aa overlap), MTCY349_40,MTCY4D9_17, MTCY338_18, MTV045_3, MTCY409_4, MTCI237_30,MTCY24G1_8, MASC_MYCLE MASC PROTEIN, U00010_6, MTV005_21,MTCY19G5_7, MTCY9F9_39, etc. Q7U2Z3 No NC_002945.3 Mycobrowser_v2 CDS 39040 39813 . - 0 Mb0037c conserved protein Mb0037c, -, len: 257 aa. Equivalent to Rv0036c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Conserved hypothetical protein, highly similar to CAB95889.1|AL359988 conserved hypothetical protein from Streptomyces (276 aa). Also some similarity to Rv3099c|MTCY164_10 (283 aa), FASTA scores: E(): 3.3e-05,(25.9 % identity in 205 aa overlap). X2BDU5,P64676 No conserved hypotheticals Rv0036c NC_002945.3 Mycobrowser_v2 CDS 39861 41186 . - 0 Mb0038c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0038c, -, len: 441 aa. Equivalent to Rv0037c,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of macrolide, showing some similarity to Rv1258c|MTCY50_24 (419 aa), FASTA score: (25.2% identity in 408 aa overlap); and to AL049826|SCH24_20 from Streptomyces coelicolor (425 aa), FASTA scores: opt: 725, E(): 0, (36.1% identity in 418 aa overlap). Also similarity with several MACROLIDE-EFFLUX PROTEINS e.g. from S. pyogenes (405 aa),FASTA scores: E(): 1.3e-06, (22.8% identity in 416 aa overlap). X2BDU7,P0A5C2 No cell wall and cell processes Rv0037c NC_002945.3 Mycobrowser_v2 CDS 2275182 2275838 . + 0 Mb2072 lppI Probable lipoprotein lppI Mb2072, lppI, len: 218 aa. Equivalent to Rv2046,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Probable lppI,lipoprotein contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7VES3 No cell wall and cell processes Rv2046 NC_002945.3 Mycobrowser_v2 CDS 41288 41896 . + 0 Mb0039 conserved protein Mb0039, -, len: 202 aa. Equivalent to Rv0038, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein, equivalent to MLCB1770_16|Q50191|Y038_MYCLE hypothetical 22.0 kDa from Mycobacterium leprae (202 aa), FASTA scores: opt: 1194,E(): 0, (88.6% identity in 202 aa overlap). Also highly similar or similar to other hypothetical proteins e.g. CAB72194.1|AL138851|SCE59.07c from Streptomyces coelicolor (193 aa); AAC06288.1|AF050466 from Mycobacterium bovis (82 aa) (similarity in N-terminus); NP_224347.1|NC_000922|YqgE from Chlamydophila pneumoniae (188 aa); YQGE_ECOLI HYPOTHETICAL 20.7 KD PROTEIN (187 aa), FASTA score: (29.5% identity in 166 aa overlap); etc. X2BDV3 No conserved hypotheticals Rv0038 NC_002945.3 Mycobrowser_v2 CDS 42417 43349 . - 0 Mb0041c mtc28 SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE RICH 28 KDA ANTIGEN) Mb0041c, mtc28, len: 310 aa. Equivalent to Rv0040c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). mtc28, secreted proline rich 28 kDa antigen protein (has hydrophobic stretch at N-terminus) (see citation below). Highly similar to O33075|PR28_MYCLE|MT10019 Proline rich 28 kDa antigen from Mycobacterium leprae (278 aa), FASTA scores: opt: 1007, E(): 0, (65.0% identity in 257 aa overlap); and Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 putative lipoprotein from Mycobacterium leprae (218 aa). C-terminal part very similar to lipoprotein Rv1016c from Mycobacterium tuberculosis. X2BDU6 No NC_002945.3 Mycobrowser_v2 CDS 58576 59070 . + 0 Mb0055 ssb single-strand binding protein ssb (helix-destabilizing protein) Mb0055, ssb, len: 164 aa. Equivalent to Rv0054,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Probable ssb,single-strand binding protein, equivalent to highly similar to others e.g. SSB_MYCLE|P46390 single-strand binding protein from Mycobacterium leprae (140 aa), FASTA scores: opt: 792, E(): 0, (92.6% identity in 135 aa overlap); and AAK30583.1|AF349434 single-stranded DNA-binding protein from Mycobacterium smegmatis (165 aa). Also highly similar to others e.g. T36594 probable single-strand binding protein from Streptomyces coelicolor (199 aa); etc. Also similar to Rv2478c|MTV008_34c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (161 aa), FASTA score: E (): 1.1e-06. Note that the putative product of this CDS corresponds to spot 3_210 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). BELONGS TO THE SSB FAMILY. X2BDW1,P0A611 No information pathways Rv0054 NC_002945.3 Mycobrowser_v2 CDS 43546 46455 . + 0 Mb0042 leuS PROBABLE LEUCYL-tRNA SYNTHETASE LEUS (LEUCINE--tRNA LIGASE) (LEURS) Mb0042, leuS, len: 969 aa. Equivalent to Rv0041,len: 969 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 969 aa overlap). Probable leucyl-tRNA synthetase (EC 6.1.1.4), equivalent to NP_301156.1|NC_002677|MLCB628_3 leucyl-tRNA synthase from Mycobacterium leprae (972 aa), FASTA score: (83.6% identity in 972 aa overlap); and highly similar to MLCB1770_20 from Mycobacterium leprae (824 aa), FASTA score: (82.8% identity in 824 aa overlap). Also highly similar to others e.g. CAB66249.1|AL136518 leucyl-tRNA synthetase from Streptomyces coelicolor (966 aa); NP_244147.1|NC_002570 leucyl-tRNA synthetase from Bacillus halodurans (806 aa); SYL_BACSU|P36430 leucyl-tRNA synthetase from Bacillus subtilis (804 aa), FASTA scores: opt: 714, E(): 3.1e-38, (43.7% identity in 938 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. X2BDV0,P67511 No information pathways Rv0041 NC_002945.3 Mycobrowser_v2 CDS 46565 47191 . - 0 Mb0043c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MARR-FAMILY) Mb0043c, -, len: 208 aa. Equivalent to Rv0042c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Possible transcriptional regulatory protein, MarR-family, highly similar except in N-terminus to CAC32228.1|AL583926 putative MarR-family regulatory protein from Mycobacterium leprae (243 aa). Also similar in part to others e.g. AB76343.1|AL158061 putative MarR-family transcriptional regulator from Streptomyces coelicolor (163 aa); NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (164 aa); NP_531782.1|NC_003304 transcriptional regulator, MarR family from Agrobacterium tumefaciens (151 aa); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv2327, Rv0880, and Rv1404. Q7U2Z1 No regulatory proteins Rv0042c NC_002945.3 Mycobrowser_v2 CDS 241710 242120 . + 0 Mb0209 POSSIBLE EXPORTED PROTEIN Mb0209, -, len: 136 aa. Equivalent to Rv0203, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Possible exported protein (has hydrophobic stretch near N-terminus). Some similarity to part of U02459|LDU02459_1 hypothetical protein from Leishmania donovani (741 aa), FASTA score: opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap). Q7U2K8 No cell wall and cell processes Rv0203 NC_002945.3 Mycobrowser_v2 CDS 47350 48084 . - 0 Mb0044c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0044c, -, len: 244 aa. Equivalent to Rv0043c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable transcriptional regulator, GntR family, similar to others e.g. NP_420584.1|NC_002696 transcriptional regulator GntR family from Caulobacter crescentus (221 aa); NP_294539.1|NC_001263 transcriptional regulator GntR family from Deinococcus radiodurans (267 aa); YIN1_STRAM|P32425 hypothetical transcriptional regulatory protein from Streptomyces ambofaciens (236 aa), FASTA scores: opt: 170, E(): 9.8e-05, (27.6% identity in 127 aa overlap); etc. Similar also to SC9B10_7 from Streptomyces coelicolor FASTA score: E():0.00038; and Rv0165c|MTCI28_5 from Mycobacterium tuberculosis (264 aa), FASTA score: (27.7% identity in 130 aa overlap). X2BDV8,P67738 No regulatory proteins Rv0043c NC_002945.3 Mycobrowser_v2 CDS 48217 49011 . - 0 Mb0045c POSSIBLE OXIDOREDUCTASE Mb0045c, -, len: 264 aa. Equivalent to Rv0044c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar to AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase from Streptomyces lavendulae (264 aa). Also similar to Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c,Rv0791c, Rv0132c, etc. Q7U2Z0 No intermediary metabolism and respiration Rv0044c NC_002945.3 Mycobrowser_v2 CDS 49027 49923 . - 0 Mb0046c POSSIBLE HYDROLASE Mb0046c, -, len: 298 aa. Equivalent to Rv0045c, len 298 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 298 aa overlap). Possible hydrolase (EC 3.-.-.-), showing similarity with others eg NP_107230.1|NC_002678 putative hydrolase from Mesorhizobium loti (278 aa); CAB56730.1|AL121600 putative hydrolase from Streptomyces coelicolor (302 aa); NP_438361.1|NC_000907 putative esterase/lipase from Haemophilus influenzae Rd (287 aa); etc. Also similar to Mycobacterium tuberculosis proteins Rv3473c, Rv1123c,Rv1938, Rv3617, Rv3670, etc. Q7U2Y9 No lipid metabolism Rv0045c NC_002945.3 Mycobrowser_v2 CDS 4344372 4344749 . - 0 Mb3954c rnpA RIBONUCLEASE P PROTEIN COMPONENT RNPA (RNaseP PROTEIN) (RNase P PROTEIN) (PROTEIN C5) Mb3954c, rnpA, len: 125 aa. Equivalent to Rv3923c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). rnpA, ribonuclease P protein component (EC 3.1.26.5) (see citations below),equivalent, but longer ~10 aa, to P46610|RNPA_MYCLE|ML2712 RIBONUCLEASE P PROTEIN COMPONENT from Mycobacterium leprae (120 aa), FASTA scores: opt: 456, E(): 3.3e-24, (63.0% identity in 119 aa overlap); and Q9L7L9|RNPA from Mycobacterium paratuberculosis (119 aa), FASTA scores: opt: 426, E(): 3.5e-22, (60.65% identity in 122 aa overlap). Also similar to many e.g. P25817|RNPA_STRBI from Streptomyces bikiniensis (123 aa), FASTA scores: opt: 174,E(): 4.2e-05, (36.8% identity in 125 aa overlap); P25814|RNPA_BACSU from Bacillus subtilis (116 aa) FASTA scores: opt: 168, E(): 0.0001, (26.85% identity in 108 aa overlap); P48206|RNPA_STRCO|STH24.03 from Streptomyces coelicolor (123 aa), FASTA scores: opt: 166, E(): 0.00015,(37.6% identity in 125 aa overlap); etc. Contains PS00648 Bacterial Ribonuclease P protein component signature. BELONGS TO THE RNPA FAMILY. X2BQ52,P0A5X9 No NC_002945.3 Mycobrowser_v2 CDS 1287656 1287940 . - 0 Mb1191c unknown protein Mb1191c, -, len: 94 aa. Equivalent to Rv1159A, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Hypothetical unknown protein. X2BH61,P0A5S3 No conserved hypotheticals Rv1159A NC_002945.3 Mycobrowser_v2 CDS 364523 364825 . + 0 Mb0307 HYPOTHETICAL PROTEIN Mb0307, -, len: 100 aa. Equivalent to Rv0299, len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 100 aa overlap). Hypothetical unknown protein. Equivalent to AAK44536.1 from Mycobacterium tuberculosis strain CDC1551 (49 aa) but longer 51 aa. Q7U2B8 No conserved hypotheticals Rv0299 NC_002945.3 Mycobrowser_v2 CDS 50005 51108 . - 0 Mb0047c ino1 MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase) Mb0047c, ino1, len: 367 aa. Equivalent to Rv0046c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 367 aa overlap). ino1 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below), equivalent to Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity in 366 aa overlap). N-terminus similar to N-terminus of myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 myo-inositol-1-phosphate synthase (510 aa), FASTA scores: opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); CAC21218.1|AJ401007 myo-inositol 1P synthase from Thermotoga sp. SG1 (335 aa); etc. Also highly similar to other hypothetical proteins e.g. AL049826|SCH24_21c hypothetical protein from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1790, E(): 0, (77.8% identity in 360 aa overlap); AE000881_1 conserved protein from M. thermoautotrophicus (368 aa); etc. X2BDV5,P59967 No NC_002945.3 Mycobrowser_v2 CDS 51169 51711 . - 0 Mb0048c conserved protein Mb0048c, -, len: 180 aa. Equivalent to Rv0047c,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 180 aa overlap). Conserved hypothetical protein, equivalent to NP_302717.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (180 aa). Also showing strong similarity to other hypothetical proteins e.g. AL049826|SCH24_22|T36587 from Streptomyces coelicolor (225 aa), FASTA scores: opt: 583,E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some similarity to Rv1176c from Mycobacterium tuberculosis and to P94443|YFIO from Bacillus subtilis (182 aa), FASTA scores: E(): 0.00066, (24.9% identity in 177 aa overlap). Also some similarity to G1163121 MITHRAMYCIN RESISTANCE DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores: opt: 143, E(): 0.0091, (29.4% identity in 180 aa overlap). Q7U2Y8 No conserved hypotheticals Rv0047c NC_002945.3 Mycobrowser_v2 CDS 53221 55689 . + 0 Mb0051 ponA1 PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE) Mb0051, ponA1, len: 822 aa. Equivalent to penicillin-binding protein, len: 822 aa, from Mycobacterium bovis strain AN5, (99% identity in 821 aa overlap), Equivalent to penicillin-binding protein from Mycobacterium bovis BCG strain Korea 1168P (99% identity in 821 aa overlap), penicillin-binding protein from Mycobacterium tuberculosis strain CDC1551 (99% identity in 817 aa overlap), bifunctional penicillin-binding protein 1A/1B ponA1: penicillin-insensitive transglycosylase + penicillin-sensitive transpeptidase from Mycobacterium tuberculosis strain F11 (99% identity with 819 aa overlap). Probable ponA1, penicillin-binding protein (class A), bienzymatic protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities,highly similar to many e.g. NP_302715.1|NC_002677 penicillin-binding protein from Mycobacterium leprae (708 aa); AAB53123.1|L39923 penicillin binding protein from Mycobacterium leprae (686 aa), FASTA scores: (82.3% identity in 679 aa overlap); Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 penicillin-binding protein 1 from Mycobacterium smegmatis (715 aa) (see citation below); CAB88838.1|AL353832 probable penicillin-binding protein from Streptomyces coelicolor (756 aa); etc. Also similar to ponA2|Rv3682|MTV025.030 BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B from Mycobacterium tuberculosis (810 aa). BELONGS TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION. UPDATE: 5' annotation extension based on de novo proteomics from Mycobacterium tuberculosis strain H37Rv under exponential conditions (See Schubert et al., 2013). Mb0051 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BDV7 No NC_002945.3 Mycobrowser_v2 CDS 55686 57368 . + 0 Mb0052 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0052, -, len: 560 aa. Equivalent to Rv0051,len:560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable conserved transmembrane protein, equivalent to NP_302714.1|NC_002677 conserved membrane protein from Mycobacterium leprae (564 aa); and highly similar to C-terminus of AAF25828.1|AF187306_1|AF187306 putative transmembrane protein from Mycobacterium smegmatis (692 aa). Also highly similar to MSGDNAB_5|G886306|L222-ORF5 (418 aa), FASTA scores: opt: 2163, E(): 0, (78.4% identity in 412 aa overlap). Also similar to AL049826|SCH24_24|T36589 probable transmembrane protein from Streptomyces coelicolor (502 aa), FASTA scores: opt: 492, E(): 1.4e-23,(35.8% identity in 522 aa overlap). Q7U2Y5 No cell wall and cell processes Rv0051 NC_002945.3 Mycobrowser_v2 CDS 57400 57963 . + 0 Mb0053 conserved protein Mb0053, -, len: 187 aa. Equivalent to Rv0052, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Conserved hypothetical protein, similar to others e.g. AL049587|SC5F2A_30S|T35272 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 531,E(): 3.4e-29, (49.5% identity in 182 aa overlap); NP_420588.1|NC_002696 ThiJ/PfpI family protein from Caulobacter crescentus (267 aa); etc. Some similarity to Escherichia coli G1100872|thiJ (198 aa), FASTA scores: opt: 178, E(): 6.1e-06, (29.9% identity in 137 aa overlap). Also similar to Rv1930c from Mycobacterium tuberculosis (174 aa). May be a membrane protein. Q7U2Y4 No conserved hypotheticals Rv0052 NC_002945.3 Mycobrowser_v2 CDS 60386 63010 . + 0 Mb0059 dnaB PROBABLE REPLICATIVE DNA HELICASE DNAB Mb0059, dnaB, len: 874 aa. Equivalent to Rv0058,len: 874 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 874 aa overlap). Probable dnaB,replicative DNA helicase (EC 3.6.1.-). Contains an intein (position 61630..62838) similar to, and in the same position as, those in Sycnechocystis and Rhodothermus marinus (see citation below). Highly similar to others e.g. DNAB_SYNY3|Q55418 replicative dna helicase (872 aa),FASTA scores: opt: 533, E(): 0, (32.5% identity in 424 aa overlap). Also similar to intein recA|E1173867|AL008967 RECA INTEIN from Mycobacterium tuberculosis (442 aa),FASTA scores: E(): 3.8e-16, (27.0% identity in 426 aa overlap). C-terminal extein (position 62839..63015) similar to many dnaB proteins e.g. NP_302709.1|NC_002677|P46394|DNAB_MYCLE REPLICATIVE DNA HELICASE from Mycobacterium leprae (604 aa); DNAB_ECOLI|P03005 replicative dna helicase from Escherichia coli (471 aa), FASTA scores: opt: 148, E(): 1.5e-07, (37.9% identity in 58 aa overlap); etc. THIS PROTEIN UNDERGOES A PROTEIN SELF SPLICING THAT INVOLVES A POST-TRANSLATIONAL EXCISION OF THE INTERVENING REGION (INTEIN) FOLLOWED BY PEPTIDE LIGATION. BELONGS TO THE HELICASE FAMILY, DNAB SUBFAMILY. IN THE INTEIN SECTION; BELONGS TO THE HOMING ENDONUCLEASE FAMILY. X2BDX5,P59966 No information pathways Rv0058 NC_002945.3 Mycobrowser_v2 CDS 63190 63882 . + 0 Mb0060 HYPOTHETICAL PROTEIN Mb0060, -, len: 230 aa. Equivalent to Rv0059, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Hypothetical unknown protein. Q7U2Y3 No conserved hypotheticals Rv0059 NC_002945.3 Mycobrowser_v2 CDS 63899 64957 . + 0 Mb0061 CONSERVED HYPOTHETICAL PROTEIN Mb0061, -, len: 352 aa. Equivalent to Rv0060, len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein, showing weak similarity to NP_104623.1|NC_002678 hypothetical protein from Mesorhizobium loti (155 aa); and AP000062|AP000062_92 hypothetical protein from Aeropyrum pernix (194 aa), FASTA scores: opt: 186, E(): 4.2e-05, (30.9% identity in 165 aa overlap). Q7U2Y2 No conserved hypotheticals Rv0060 NC_002945.3 Mycobrowser_v2 CDS 65002 65340 . - 0 Mb0062A Hypothetical protein Mb0062A, len: 112 aa. Equivalent to Rv0061c len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein supported by RNA-seq data. Similar to MMAR_3839, 76% identity in 112 aa overlap. Replaces questionable ORF Rv0061 (MTV030.04). X2BDW9 No conserved hypotheticals Rv0061c NC_002945.3 Mycobrowser_v2 CDS 309099 309842 . - 0 Mb0265c CONSERVED HYPOTHETICAL PROTEIN Mb0265c, -, len: 247 aa. Equivalent to Rv0259c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 247 aa overlap). Conserved hypothetical protein, showing some similarity to Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis (281 aa), FASTA scores: E(): 9.5e-16, (33.6 % identity in 235 aa overlap). Also some similarity with CAC33938.1|AL589708 putative secreted protein from Streptomyces coelicolor (248 aa). Q7U2F6 No conserved hypotheticals Rv0259c NC_002945.3 Mycobrowser_v2 CDS 66913 68352 . + 0 Mb0064 POSSIBLE OXIDOREDUCTASE Mb0064, -, len: 479 aa. Equivalent to Rv0063, len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase from Arthrobacter oxidans (458 aa), FASTA scores: opt: 343,E(): 3.4e-13, (27.4% identity in 467 aa overlap); AAD28454.1|AF127374_9|AF127374|MitR oxidase from Streptomyces lavendulae (514 aa); AAF81732.1|AF254925|EncM putative FAD-dependent oxygenase from Streptomycesmaritimus (464 aa); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3107c, Rv1257c,etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site. Q7U2X9 No intermediary metabolism and respiration Rv0063 NC_002945.3 Mycobrowser_v2 CDS 68610 71549 . + 0 Mb0065 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0065, -, len: 979 aa. Equivalent to Rv0064, len: 979 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 979 aa overlap). Probable conserved transmembrane protein, highly similar to NP_301532.1| (NC_002677) putative integral membrane protein from Mycobacterium leprae (983 aa). Also similar to other hypothetical proteins from ARCHAEOGLOBUS FULGIDUS and Synecocystis sp. e.g. P72637|D90899 HYPOTHETICAL 117.2 KD PROTEIN from SYNECHOCYSTIS SP. (1032 aa), FASTA scores: opt: 1004, E(): 3.6e-32, (31.0 % identity in 848 aa overlap); and CAC01334.1|AL390968 putative integral membrane protein (fragment) from Streptomyces coelicolor (815 aa); etc. Also similar to Rv3193c from Mycobacterium tuberculosis (992 aa), FASTA score: (50.3% identity in 985 aa overlap). Contains probable coiled-coil domain from aa 948 to 976. X2BDX2,Q7U2X8 No cell wall and cell processes Rv0064 NC_002945.3 Mycobrowser_v2 CDS 71616 71855 . + 0 Mb0065A vapB1 Possible antitoxin VapB1 Mb0065A, len: 79 aa. Equivalent to Rv0064A len: 79 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 79 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB1,antitoxin, part of toxin-antitoxin (TA) operon with Rv0065 (See Arcus et al., 2005; Pandey and Gerdes, 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv0300 (73 aa),Rv1721c (75 aa) X2BDX1 No virulence, detoxification, adaptation Rv0064A NC_002945.3 Mycobrowser_v2 CDS 71848 72249 . + 0 Mb0066 vapc1 possible toxin vapc1 Mb0066, -, len: 133 aa. Equivalent to Rv0065, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis: Rv0960 (127 aa),Rv1720c (129 aa), and Rv0549c (137 aa). Q7U2X7 No virulence, detoxification, adaptation Rv0065 NC_002945.3 Mycobrowser_v2 CDS 72301 74538 . - 0 Mb0067c icd2 PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) Mb0067c, icd2, len: 745 aa. Equivalent to Rv0066c,len: 745 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 745 aa overlap). Probable icd2,isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42),equivalent to NP_302705.1|NC_002677 isocitrate dehydrogenase [NADP] from Mycobacterium leprae (746 aa). Also highly similar to many members of the monomeric-type family of IDH e.g. NP_251314.1|NC_002516 isocitrate dehydrogenase from Pseudomonas aeruginosa (741 aa); IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106,E(): 0, (61.4% identity in 735 aa overlap); NP_230786.1|NC_002505 isocitrate dehydrogenase [Vibrio cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FAMILY OF IDH. Q7U2X6 No NC_002945.3 Mycobrowser_v2 CDS 74656 75225 . - 0 Mb0068c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0068c, -, len: 189 aa. Equivalent to Rv0067c,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 189 aa overlap). Possible transcriptional regulator, highly similar except in N-terminus to T44726 probable transcription regulator from Mycobacterium leprae (189 aa), FASTA scores: opt: 829,E(): 0, (68.3% identity in 189 aa overlap). And similar to others, often many members of the tetR family, e.g. T36918 probable transcription regulator from Streptomyces coelicolor (202 aa); NP_535866.1|NC_003306 transcriptional regulator TetR family from Agrobacterium tumefaciens strain C58 (Dupont) (194 aa); UIDR_ECOLI|Q59431 uid operon repressor (gus operon repressor) from Escherichia coli (196 aa), FASTA scores: opt: 200, E(): 7.2e-06, (24.7% identity in 186 aa overlap); etc. Also similar to MTCY8D5_28 from Mycobacterium tuberculosis cosmid (229 aa), FASTA score: (32.7% identity in 168 aa overlap). Contains probable helix-turn-helix motif from aa 34 to 55 (Score 1523, +4.37 SD). Q7U2X5 No regulatory proteins Rv0067c NC_002945.3 Mycobrowser_v2 CDS 75328 76239 . + 0 Mb0069 PROBABLE OXIDOREDUCTASE Mb0069, -, len: 303 aa. Equivalent to Rv0068, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Probable oxidoreductase (EC 1.-.-.-), equivalent to NP_301343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (304 aa). Also highly similar to many e.g. NP_485762.1|NC_003272 probable oxidoreductase from Nostoc sp. PCC 7120 (311 aa); NP_279536.1|NC_002607|YajO1 probable oxidoreductase from Halobacterium sp. NRC-1 (316 aa); OXIR_STRAT|Q03326 probable oxidoreductase from Streptomyces antibioticus (298 aa), FASTA scores: opt: 430, E(): 1.3e-16, (34.9% identity in 295 aa overlap); etc. Also highly similar to MTV037_3 and MTV022_13 from Mycobacterium tuberculosis. Q7U2X4 No intermediary metabolism and respiration Rv0068 NC_002945.3 Mycobrowser_v2 CDS 76264 77649 . - 0 Mb0070c sdaA PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE DEAMINASE) (SDH) (L-SD) Mb0070c, sdaA, len: 461 aa. Equivalent to Rv0069c,len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable sdaA,L-serine dehydratase (EC 4.3.1.17), equivalent to NP_302203.1| NC_002677 L-serine dehydratase from Mycobacterium leprae (458 aa). Also highly similar to many e.g. NP_251133.1|NC_002516 L-serine dehydratase from Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO L-SERINE DEHYDRATASE from Streptomyces coelicolor (455 aa); SDHL_ECOLI|P16095 L-serine dehydratase 1 from Escherichia coli (454 aa), FASTA scores: opt: 1381, E(): 0, (51.1% identity in 460 aa overlap); etc. BELONGS TO THE IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE). X2BDX6,P66774 No NC_002945.3 Mycobrowser_v2 CDS 89610 89954 . + 0 Mb0084 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0084, -, len: 114 aa. Equivalent to Rv0081, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Probable transcriptional regulator, highly similar to others e.g. AL078610|SCH35_52|T36657 probable transcription regulator from Streptomyces coelicolor (117 aa), FASTA scores: opt: 404, E(): 4.8e-22, (58.2% identity in 110 aa overlap); AAG02351.1|AF210249_10|AF210249 metal-dependent regulatory protein from Streptomyces verticillus (113 aa); NP_435817.1|NC_003037 Putative transcriptional regulator from Sinorhizobium meliloti (115 aa); etc. Q7U2W1 No regulatory proteins Rv0081 NC_002945.3 Mycobrowser_v2 CDS 103745 104698 . - 0 Mb0097c CONSERVED HYPOTHETICAL PROTEIN Mb0097c, -, len: 317 aa. Equivalent to Rv0094c,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(97.8% identity in 317 aa overlap). Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (49.4% identity in 79 aa overlap). Q7U2V3 No insertion seqs and phages Rv0094c NC_002945.3 Mycobrowser_v2 CDS 77646 78923 . - 0 Mb0071c glyA2 serine hydroxymethyltransferase glya2 (serine methylase 2) (shmt 2) Mb0071c, glyA2, len: 425 aa. Equivalent to Rv0070c,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Probable glyA2, serine hydroxymethyltransferase (EC 2.1.2.1), equivalent to NP_302318.1|NC_002677 serine hydroxymethyltransferase from Mycobacterium leprae (426 aa). Also highly similar to many e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE from Streptomyces coelicolor (420 aa); AAK60516.1|AF327063_1|AF327063 serine hydroxymethyltransferase from Corynebacterium glutamicum (434 aa); GLYA_ECOLI|P00477 serine hydroxymethyltransferase from Escherichia coli (417 aa),FASTA scores: opt: 1462, E(): 0, (54.3% identity in 416 aa overlap); etc. Also highly similar to MTV017_46 from Mycobacterium tuberculosis. Contains PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE. X2BDX9,Q7U2X3 No NC_002945.3 Mycobrowser_v2 CDS 79513 80229 . + 0 Mb0072 POSSIBLE MATURASE Mb0072, -, len: 238 aa. Equivalent to Rv0071, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 238 aa overlap). Possible maturase,similar to many proteins of the group II intron maturase family e.g. P95451|U77945 MATURASE-RELATED PROTEIN from PSEUDOMONAS ALCALIGENES (297 aa), FASTA scores: opt: 395,E(): 1.7e-20, (43.5% identity in 147 aa overlap); N-terminus of AAD16434.1|AF101076 maturase-related protein from Pseudomonas putida (473 aa); N-terminus of NP_437373.1|NC_003078 putative reverse transcriptasematurase protein from Sinorhizobium meliloti (453 aa); etc. Also similar to MLCL581_1 from Mycobacterium leprae. Contains 5 VDP repeats at N-terminus, these are also found in two Streptococcus plasmid hypothetical proteins Q52246|X17092 and Q54942|X66468. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp insertion (*-cggtggacc) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (238 aa versus 235 aa). Q7U2X2 No information pathways Rv0071 NC_002945.3 Mycobrowser_v2 CDS 80660 81709 . + 0 Mb0073 PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb0073, -, len: 349 aa. Equivalent to Rv0072, len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Probable glutamine-transport transmembrane protein ABC-transporter (see citation below), showing weak similarity to NP_465894.1|NC_003210 protein similar to putative ABC-transporter transmembrane subunit from Listeria monocytogenes EGD-e (367 aa); NP_471800.1|NC_003212 protein similar to putative ABC-transporter transmembrane subunit from Listeria innocua (367 aa); E1204111|AJ003195 MEMBRANE SPANNING SUBUNIT DEVC from ANABAENA VARIABILIS (385 aa), FASTA scores: opt: 155, E(): 8.1e-07, (22.0% identity in 381 aa overlap). Also highly similar to Rv2563|Y0A5_MYCTU|Q50735|MTCY9C4.05c from Mycobacterium tuberculosis (388 aa), FASTA scores: E(): 0, (76.2% identity in 349 aa overlap). Note that supposed act with near ORF Rv0073|MTV030.17 ATP-binding protein ABC-transporter. Q7U2X1 No cell wall and cell processes Rv0072 NC_002945.3 Mycobrowser_v2 CDS 81712 82554 . + 0 Mb0074 PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER GLNQ Mb0074, -, len: 280 aa. Equivalent to 5' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (94.9% identity in 275 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075. Q7U2X0 No NC_002945.3 Mycobrowser_v2 CDS 82491 82703 . + 0 Mb0075 PROBABLE GLUTAMINE-TRANSPORT PROTEIN ABC TRANSPORTER GLNQ Mb0075, -, len: 70 aa. Equivalent to 3' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 70 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075. No NC_002945.3 Mycobrowser_v2 CDS 86563 87168 . + 0 Mb0080 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0080, -, len: 201 aa. Equivalent to Rv0078, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Probable transcriptional regulator, equivalent to NP_302706.1|NC_002677 putative TetR-family transcriptional regulator from Mycobacterium leprae (236 aa), FASTA scores: opt: 755, E(): 0, (71.4% identity in 175 aa overlap). Also similar to others e.g. NP_103770.1|NC_002678 probable transcriptional regulator from Mesorhizobium loti (208 aa); NP_384275.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (197 aa); NP_250960.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (196 aa); etc. Also similar to TETC_ECOLI|P28815 transposon tn10 tetc protein from Escherichia coli (197 aa), FASTA scores: opt: 181, E(): 9.7e-05, (24.8% identity in 165 aa overlap). Contains probable helix-turn-helix motif from aa 35 to 56 (Score 1348, +3.78 SD). Q7U2W5 No regulatory proteins Rv0078 NC_002945.3 Mycobrowser_v2 CDS 87833 88039 . - 0 Mb0081A Conserved protein Mb0081A, len: 68 aa. Equivalent to Rv0078B len: 68 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 68 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BDY8 No conserved hypotheticals Rv0078B NC_002945.3 Mycobrowser_v2 CDS 88239 89060 . + 0 Mb0082 unknown protein Mb0082, -, len: 273 aa. Equivalent to Rv0079, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Hypothetical unknown protein. Q7U2W3 No conserved hypotheticals Rv0079 NC_002945.3 Mycobrowser_v2 CDS 89057 89515 . + 0 Mb0083 CONSERVED HYPOTHETICAL PROTEIN Mb0083, -, len: 152 aa. Equivalent to Rv0080, len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 152 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Streptomyces coelicolor e.g. SCJ12.26|AL109989|SCJ12_24 from Streptomyces coelicolor cosmid J1 (137 aa), FASTA scores: opt: 291, E(): 4e-13, (46.5% identity in 129 aa overlap); etc. Q7U2W2 No conserved hypotheticals Rv0080 NC_002945.3 Mycobrowser_v2 CDS 89959 90438 . + 0 Mb0085 PROBABLE OXIDOREDUCTASE Mb0085, -, len: 159 aa. Equivalent to Rv0082, len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 159 aa overlap). Probable oxidoreductase (EC 1.-.-.-), highly highly similar or similar to other various oxidoreductases e.g. NP_143304.1|NC_000961 NADH-ubiquinone oxidoreductase subunit from Pyrococcus horikoshii (173 aa); NP_126406.1|NC_000868 CO-induced hydrogenase related,subunit L from Pyrococcus abyssi (170 aa); HYCG_ECOLI|P16433 formate hydrogenlyase subunit 7 from Escherichia coli (255 aa), FASTA scores: opt: 442, E(): 8e-29, (43.2% identity in 148 aa overlap); etc. Q7U2W0 No intermediary metabolism and respiration Rv0082 NC_002945.3 Mycobrowser_v2 CDS 90435 92363 . + 0 Mb0086 PROBABLE OXIDOREDUCTASE Mb0086, -, len: 642 aa. Equivalent to Rv0083, len: 640 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 640 aa overlap). Probable oxidoreductase (EC 1.-.-.-), showing some similarity to other various oxidoreductases e.g. AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa); HYFB_ ECOLI|P23482 hydrogenase-4 component b from Escherichia coli strain K12 (672 aa), FASTA scores: opt: 995, E(): 0,(32.2% identity in 571 aa overlap); AAF13041.1|AF157639_1|AF157639 putative formate hydrogenlyase integral membrane subunit from Desulfitobacterium dehalogenans (637 aa); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Q7U2V9 No intermediary metabolism and respiration Rv0083 NC_002945.3 Mycobrowser_v2 CDS 92363 93313 . + 0 Mb0087 hycD POSSIBLE FORMATE HYDROGENLYASE HYCD (FHL) Mb0087, hycD, len: 316 aa. Equivalent to Rv0084,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 316 aa overlap). Possible hycD (alternate gene name: hevD), formate hydrogenlyase (EC 1.-.-.-), integral membrane protein, similar to others e.g. HYCD_ECOLI|P16430 formate hydrogenlyase subunit 4 from Escherichia coli (307 aa), FASTA scores: opt: 570,E(): 2.1e-26, (33.8% identity in 305 aa overlap); AAK06856.1|AF335723_2|AF335723 formate hydrogenlyase subunit 4 from Burkholderia pseudomallei (316 aa); NP_457244.1|NC_003198 formate hydrogenlyase subunit 4 from Salmonella enterica subsp. enterica serovar Typhi (307 aa); etc. Also similar to NUOH_ECOLI|P33603 NADH dehydrogenase I chain H from Escherichia coli (325 aa),FASTA scores: opt: 207, E(): 9.5e-06, (26.5% identity in 260 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY. Q7U2V8 No intermediary metabolism and respiration Rv0084 NC_002945.3 Mycobrowser_v2 CDS 93324 93986 . + 0 Mb0088 hycP POSSIBLE HYDROGENASE HYCP Mb0088, hycP, len: 220 aa. Equivalent to Rv0085,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Possible hycP,hydrogenase (EC 1.-.-.-), integral membrane protein,weakly similar to P77524|HYFE_ECOLI HYDROGENASE-4 COMPONENT E from Escherichia coli (216 aa), FASTA scores: opt: 204, E():1.2e-07, (25.5% identity in 216 aa overlap). X2BDZ6,P64682 No intermediary metabolism and respiration Rv0085 NC_002945.3 Mycobrowser_v2 CDS 162834 163439 . - 0 Mb0140c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0140c, -, len: 201 aa. Equivalent to Rv0135c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Possible transcriptional regulator, weakly similar to others e.g. P32398|YHGD_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Bacillus subtilis (191 aa), FASTA scores: opt: 145,E(): 0.0012, (21.0% identity in 162 aa overlap). Q7U2S1 No regulatory proteins Rv0135c NC_002945.3 Mycobrowser_v2 CDS 93986 95452 . + 0 Mb0089 hycQ POSSIBLE HYDROGENASE HYCQ Mb0089, hycQ, len: 488 aa. Equivalent to Rv0086,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Possible hycQ,hydrogenase (EC 1.-.-.-), integral membrane protein,weakly similar to P77437|HYFF_ECOLI HYDROGENASE-4 COMPONENT F from Escherichia coli (526 aa), FASTA scores: opt: 948, E(): 0, (35.9% identity in 493 aa overlap); and AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa). Also similar to d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L from Escherichia coli (613 aa), FASTA scores: opt: 360,E():3.2e-13, (27.9% identity in 488 aa overlap); and to NUON_ECOLI|P33608 NADH dehydrogenase I chain N from Escherichia coli (425 aa), FASTA scores: opt: 375, E(): 3.9e-14, (25.0% identity in 432 aa overlap). Q7U2V7 No intermediary metabolism and respiration Rv0086 NC_002945.3 Mycobrowser_v2 CDS 95449 96927 . + 0 Mb0090 hycE possible formate hydrogenase hyce (fhl) Mb0090, hycE, len: 492 aa. Equivalent to Rv0087,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Possible hycE (alternate gene name: hevE), formate hydrogenlyase (EC 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate hydrogenlyase subunit 5 from Escherichia coli (569 aa),FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in 449 aa overlap); NP_457243.1|NC_003198 formate hydrogenlyase subunit 5 from Salmonella enterica subsp. enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 formate hydrogenlyase subunit 5 from Methanothermobacter thermautotrophicus (370 aa); etc. Also some similarity with NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from Escherichia coli (407 aa), FASTA scores: opt: 245, E(): 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO THE COMPLEX I 49 kDa SUBUNIT FAMILY. Q7U2V6 No intermediary metabolism and respiration Rv0087 NC_002945.3 Mycobrowser_v2 tRNA 4153262 4153350 . - 0 serT serT tRNA-Ser serT, len: 89 nt. Equivalent to serT, len: 89 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 nt overlap). tRNA-Ser, anticodon gct. No NC_002945.3 Mycobrowser_v2 CDS 97793 98386 . + 0 Mb0092 POSSIBLE METHYLTRANSFERASE/METHYLASE Mb0092, -, len: 197 aa. Equivalent to Rv0089, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Possible methyltransferase (EC 2.1.1.-), showing some weak similarity to others e.g. NP_299749.1|NC_002488 3-demethylubiquinone-9 3-methyltransferase from Xylella fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative methyltransferase from Streptomyces coelicolor (285 aa); NP_111415.1|NC_002689 Predicted SAM-dependent methyltransferase from Thermoplasma volcanium (245 aa); etc. Also some similarity with many biotin biosynthesis proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. X2BE12,P65347 No intermediary metabolism and respiration Rv0089 NC_002945.3 Mycobrowser_v2 CDS 98515 99285 . + 0 Mb0093 POSSIBLE MEMBRANE PROTEIN Mb0093, -, len: 256 aa. Equivalent to Rv0090, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible membrane protein. X2BE01,P64684 No cell wall and cell processes Rv0090 NC_002945.3 Mycobrowser_v2 CDS 885641 886240 . - 0 Mb0813c HYPOTHETICAL PROTEIN Mb0813c, -, len: 199 aa. Equivalent to Rv0789c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Hypothetical unknown protein. Q7U198 No conserved hypotheticals Rv0789c NC_002945.3 Mycobrowser_v2 CDS 99719 100486 . + 0 Mb0094 mtn probable bifunctional mta/sah nucleosidase mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + s-adenosylhomocysteine nucleosidase (s-adenosyl-l-homocysteine homocysteinylribohydrolase) Mb0094, mtn, len: 255 aa. Equivalent to Rv0091,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Probable mtn (alternate gene name: pfs), MTA/SAH nucleosidase,including 5'-methylthioadenosine nucleosidase (EC 3.2.2.16) and S-adenosylhomocysteine nucleosidase (EC 3.2.2.9), similar to others e.g. NP_521493.1|NC_003295 PROBABLE BIFUNCTIONAL PROTEIN (MTA/SAH NUCLEOSIDASE) (P46): 5'-METHYLTHIOADENOSINE NUCLEOSIDASE AND S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from Ralstonia solanacearum (261 aa); AAC45731.1|U55214 Pfs from Treponema pallidum (249 aa); P96122|MTN_TREPA MTA/SAH NUCLEOSIDASE from Treponema pallidum (269 aa); PFS_ECOLI|P24247 pfs protein (p46) from Escherichia coli (232 aa), FASTA scores: opt: 214, E(): 3.8e-08, (30.5% identity in 246 aa overlap); etc. BELONGS TO THE MTN FAMILY. X2BE00,P67657 No intermediary metabolism and respiration Rv0091 NC_002945.3 Mycobrowser_v2 CDS 100618 102903 . + 0 Mb0095 ctpA cation transporter p-type atpase a ctpa Mb0095, ctpA, len: 761 aa. Equivalent to Rv0092,len: 761 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 761 aa overlap). Probable ctpA,cation-transporting P-type ATPase A (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. CTPA_MYCLE|P46839 cation-transporting P-type ATPase A from Mycobacterium leprae (780 aa), FASTA scores: opt: 3454,E(): 0, (74.4% identity in 741 aa overlap); CAB66270.1|AL136519 probable cation-transporting P-type ATPase from Streptomyces coelicolor (760 aa); NP_391230.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); etc. Also highly similar to MTCY251.22c from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain,and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES),SUBFAMILY IB. Q7U2V5 No cell wall and cell processes Rv0092 NC_002945.3 Mycobrowser_v2 CDS 419978 420637 . + 0 Mb0357 HYPOTHETICAL PROTEIN Mb0357, -, len: 219 aa. Equivalent to Rv0349, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Hypothetical unknown protein. Q7U273 No conserved hypotheticals Rv0349 NC_002945.3 Mycobrowser_v2 CDS 104469 105251 . - 0 Mb0098c CONSERVED HYPOTHETICAL PROTEIN Mb0098c, -, len: 260 aa. Equivalent to Rv1588 and Rv0095c, len: 222 aa and 136 aa, from Mycobacterium tuberculosis strain H37Rv, (98.2% identity in 222 aa overlap and 92.5% identity in 134 aa overlap). Member of 13E12 repeat, also partially similar to AF0418|AF041819_8 from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% identity in 96 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Q7U2V2 No Rv1588 NC_002945.3 Mycobrowser_v2 CDS 105360 106751 . + 0 Mb0099 PPE1 ppe family protein ppe1 Mb0099, PPE1, len: 463 aa. Equivalent to Rv0096,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 463 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. Z46257|MLACEA_3 aceA gene for isocitrate L from M. leprae (438 aa), FASTA scores: opt: 1207, E(): 0, (55.3% identity in 380 aa overlap). Also similar to Z97559|MTCY261_19 from Mycobacterium tuberculosis (473 aa), FASTA score: (40.2% identity in 478 aa overlap); YHS6_MYCTU|P42611 hypothetical 50.6 kd protein (517 aa),FASTA scores: opt: 365, E(): 4.6e-12, (37.6% identity in 178 aa overlap). Also similar to MTCY274.23c from M. tuberculosis FASTA score: (31.1% identity in 383 overlap). Some similarity also to MTCY31.06c and MTCY48.17 and other mycobacterial PPE family proteins. Q7U2V1 No PE/PPE Rv0096 NC_002945.3 Mycobrowser_v2 CDS 106770 107639 . + 0 Mb0100 POSSIBLE OXIDOREDUCTASE Mb0100, -, len: 289 aa. Equivalent to Rv0097, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to NP_302343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (289 aa). Also highly similar to BAB69377.1|AB070955 putative oxidoreductase from Streptomyces avermitilis (296 aa); and weakly similar to others e.g. NP_518867.1|NC_003295 PUTATIVE ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE OXIDOREDUCTASE PROTEIN from Ralstonia solanacearum (301 aa); NP_286110.1|NC_002655 taurine dioxygenase (2-oxoglutarate-dependent) from Escherichia coli strain O157:H7 (283 aa); NP_252624.1|NC_002516 taurine dioxygenase from Pseudomonas aeruginosa (277 aa); ECAE00014310 (283 aa), FASTA scores: opt: 304, E(): 2.6e-13, (27.8% identity in 288 aa overlap); TFDA_ALCEU|P10088 2,4-dichlorophenoxyacetate monooxygenase from A. eutropha (287 aa), FASTA scores: opt: 188, E(): 3.5e-06, (26.6% identity in 188 aa overlap); etc. Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature. X2BE10,P67756 No intermediary metabolism and respiration Rv0097 NC_002945.3 Mycobrowser_v2 CDS 107636 108187 . + 0 Mb0101 fcot probable fatty acyl coa thioesterase type iii fcot Mb0101, -, len: 183 aa. Equivalent to Rv0098, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, equivalent to CAC30948.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (183 aa). Also some similarity with BAB69378.1|AB070955 hypothetical protein from Streptomyces avermitilis (172 aa). X2BE08 No lipid metabolism Rv0098 NC_002945.3 Mycobrowser_v2 CDS 122353 123867 . + 0 Mb0107 CONSERVED HYPOTHETICAL PROTEIN Mb0107, -, len: 504 aa. Equivalent to Rv0104, len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 504 aa overlap). Conserved hypothetical protein, showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta regulatory subunit from Homo sapiens (380 aa); etc. Q7U2U8 No conserved hypotheticals Rv0104 NC_002945.3 Mycobrowser_v2 CDS 108192 109814 . + 0 Mb0102 fadD10 POSSIBLE FATTY-ACID-COA LIGASE FADD10 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0102, fadD10, len: 540 aa. Equivalent to Rv0099,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). Possible fadD10,fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to MLACEA_4|Q50176 LONG CHAIN FATTY ACID-COA LIGASE from Mycobacterium leprae (532 aa), FASTA scores: opt: 2580,E(): 0, (74.6% identity in 531 aa overlap). Also similar to many e.g. BAB69379.1|AB070955 long-chain fatty acid--CoA ligase from Streptomyces avermitilis (518 aa); NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (530 aa); NP_435326.1|NC_003037 probable long chain fatty acid CoA ligase from Sinorhizobium meliloti (508 aa); etc. Also similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase from Bacillus subtilis (572 aa), FASTA scores: opt: 415,E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains PS00455 putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U2V0 No NC_002945.3 Mycobrowser_v2 CDS 109819 110055 . + 0 Mb0103 CONSERVED HYPOTHETICAL PROTEIN Mb0103, -, len: 78 aa. Equivalent to Rv0100,(MTCY251.19), len: 78 aa. Conserved hypothetical protein,equivalent only to CAC30950.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (78 aa). X2BE11 No NC_002945.3 Mycobrowser_v2 CDS 161962 162345 . + 0 Mb0139-1 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-1, -, len: 128 aa. Pseudogene part1 of Rv0134/ephF No NC_002945.3 Mycobrowser_v2 CDS 162345 162452 . + 0 Mb0139-2 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-2, -, len: 36 aa. Pseudogene part2 of Rv0134/ephF No NC_002945.3 Mycobrowser_v2 CDS 110037 117575 . + 0 Mb0104 nrp PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) Mb0104, nrp, len: 2512 aa. Equivalent to Rv0101,len: 2512 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2512 aa overlap). Probable nrp,peptide synthetase (EC 6.-.-.-), similar to others e.g. AAD44234.1|AF143772_40|PstB peptide synthetase from Mycobacterium avium (2552 aa); 7476034|S77657 cyclic peptide synthetase from Mycobacterium leprae (1401 aa),FASTA scores: opt: 4268, E(): 0, (65.7% identity in 1091 aa overlap); part of CAB55600.1|AJ238027 peptide synthetase from Mycobacterium smegmatis (5990). Also similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF protein from Bacillus subtilis (2378 aa); SRF1_BACSU|P27206 surfactin synthetase subunit 1 (3587 aa), FASTA scores: opt: 1708, E(): 0, (30.6% identity in 1633 aa overlap): etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), 2 x PS00455 Putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. THOUGHT TO BE NOT INVOLVED IN MYCOBACTIN BIOSYNTHESIS (see citation below). Q7U2U9 No lipid metabolism Rv0101 NC_002945.3 Mycobrowser_v2 CDS 117750 119735 . + 0 Mb0105 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0105, -, len: 661 aa. Equivalent to Rv0102, len: 661 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 661 aa overlap). Probable conserved integral membrane protein, highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium leprae (659 aa), FASTA scores: opt: 3107, E(): 0, (70.2% identity in 662 aa overlap). Also similar to others e.g. CAC01497.1|AL391017 putative integral membrane protein from Streptomyces coelicolor (316 aa); etc. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. X2BE16,P64690 No cell wall and cell processes Rv0102 NC_002945.3 Mycobrowser_v2 CDS 119951 122209 . - 0 Mb0106c ctpB PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB Mb0106c, ctpB, len: 752 aa. Equivalent to Rv0103c,len: 752 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 752 aa overlap). Probable ctpB,cation-transporting P-type ATPase B (transmembrane protein) (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 cation-transporting P-type ATPase B from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% identity in 752 aa overlap). Also highly similar to others e.g. CAB96031.1|AL360055 putative metal transporter ATPase from Streptomyces coelicolor (753 aa); NP_241423.1|NC_002570 copper-transporting ATPase from Bacillus halodurans (806 aa); etc. Also highly similar to Z46257|MLACEA_7 aceA gene for isocitrate L from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615,E():0, (76.5% identity in 752 aa overlap). And similar to MTCY251.11 from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain, PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. X2BE13,P59947 No NC_002945.3 Mycobrowser_v2 CDS 124016 124300 . - 0 Mb0108c rpmB1 50s ribosomal protein l28-1 rpmb1 Mb0108c, rpmB1, len: 94 aa. Equivalent to Rv0105c,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Probable rpmB1, 50S ribosomal protein L28-1, highly similar to others e.g. Q9X8K8|R28B_STRCO 50S RIBOSOMAL PROTEIN L28-2 from Streptomyces coelicolor (78 aa); RL28_ECOLI|P02428 50s ribosomal protein l28 from Escherichia coli (77 aa), FASTA scores: opt: 167, E(): 6.2e-06, (40.7% identity in 59 aa overlap); etc. Also similar to MTCY63A_2 from Mycobacterium tuberculosis. BELONGS TO THE L28P FAMILY OF RIBOSOMAL PROTEINS. X2BE14,P0A5V7 No NC_002945.3 Mycobrowser_v2 CDS 124410 125606 . + 0 Mb0109 CONSERVED HYPOTHETICAL PROTEIN Mb0109, -, len: 398 aa. Equivalent to Rv0106, len: 398 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 398 aa overlap). Conserved hypothetical protein, similar to others e.g. AL049841|SCE9_33 from Streptomyces coelicolor (370 aa),FASTA scores: opt: 282, E(): 2.5e-11, (32.0% identity in 381 aa overlap); etc. Some similarity to P94400 HOMOLOGUE TO NITRILE HYDRATASE REGION from Bacillus subtilis (397 aa), FASTA scores: opt: 226, E(): 5.4e-08, (26.4% identity in 405 aa overlap). Also similar to COBW_PSEDE|P29937 FASTA score: (25.3% identity in 186 aa overlap); and P47K_PSECL|P31521 47 kd protein (p47k) (419 aa), FASTA score: (25.9% identity in 401 aa overlap). X2BE15 No conserved hypotheticals Rv0106 NC_002945.3 Mycobrowser_v2 CDS 704058 704444 . + 0 Mb0623 HYPOTHETICAL PROTEIN Mb0623, -, len: 128 aa. Equivalent to Rv0607, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Hypothetical unknown protein. Q7U1M9 No conserved hypotheticals Rv0607 NC_002945.3 Mycobrowser_v2 CDS 125701 130578 . - 0 Mb0111c ctpI PROBABLE CATION-TRANSPORTER ATPASE I CTPI Mb0111c, ctpI, len: 1625 aa. Equivalent to 5' end of Rv0107c, len: 1632 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1572 aa overlap). Probable ctpI, cation-transporting ATPase I P-type (EC 3.6.3.-), highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium leprae (1609 aa); and similar to others e.g. CAB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 603, E(): 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium tuberculosis, FASTA score: (34.4% identity in 796 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-t) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U2U7 No NC_002945.3 Mycobrowser_v2 CDS 130932 131141 . - 0 Mb0112c HYPOTHETICAL PROTEIN Mb0112c, -, len: 69 aa. Equivalent to Rv0108c, len: 69 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 69 aa overlap). Hypothetical unknown protein. Q7U2U6 No conserved hypotheticals Rv0108c NC_002945.3 Mycobrowser_v2 CDS 383909 384571 . - 0 Mb0322c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0322c, -, len: 220 aa. Equivalent to Rv0314c,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 220 aa overlap). Possible conserved membrane protein, with hydrophobic stretch from residues ~75-100. Similar in C-terminal part to Mycobacterium tuberculosis proteins Rv0679c and Rv0680c. Q7U2A3 No cell wall and cell processes Rv0314c NC_002945.3 Mycobrowser_v2 CDS 162696 162863 . + 0 Mb0139-4 ephf possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase) Mb0139-4, -, len: 55 aa. Pseudogene part4 of Rv0134/ephF. No NC_002945.3 Mycobrowser_v2 CDS 131420 132910 . + 0 Mb0113 PE_PGRS1 pe-pgrs family protein pe_pgrs1 Mb0113, PE_PGRS1, len: 496 aa. Equivalent to Rv0109, len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 496 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. Q50615|Y0DP_MYCTU HYPOTHETICAL GLYCINE-RICH 40.8 KD PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1772, E(): 0, (57.3% identity in 513 aa overlap); etc. Q7U2U5 No PE/PPE Rv0109 NC_002945.3 Mycobrowser_v2 CDS 167901 168827 . + 0 Mb0147 CONSERVED HYPOTHETICAL PROTEIN Mb0147, -, len: 308 aa. Equivalent to Rv0142, len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). Q7U2R6 No conserved hypotheticals Rv0142 NC_002945.3 Mycobrowser_v2 CDS 133058 133807 . + 0 Mb0114 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0114, -, len: 249 aa. Equivalent to Rv0110, len 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Probable conserved integral membrane protein, similar to many e.g. AL079308|SCH69_25 from Streptomyces coelicolor (297 aa),FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity in 251 aa overlap); P54493|YQGP_BACSU HYPOTHETICAL 56.4 KD PROTEIN from Bacillus subtilis (507 aa), FASTA scores: opt: 320, E(): 4e-15, (32.4% identity in 210 aa overlap); etc. Q7U2U4 No cell wall and cell processes Rv0110 NC_002945.3 Mycobrowser_v2 CDS 133988 136045 . + 0 Mb0115 POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE Mb0115, -, len: 685 aa. Equivalent to Rv0111, len: 685 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 685 aa overlap). Possible transmembrane acyltransferase (EC 2.3.1.-), equivalent to AA22904.1|AL035300 putative acyltransferase from Mycobacterium leprae (696 aa). Also similar to others e.g. C69975 acyltransferase homolog yrhL from Bacillus subtilis (634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4% identity in 382 aa overlap). Very similar to Mycobacterium tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc. Q7U2U3 No intermediary metabolism and respiration Rv0111 NC_002945.3 Mycobrowser_v2 CDS 136327 137283 . + 0 Mb0116 gca POSSIBLE GDP-MANNOSE 4,6-DEHYDRATASE GCA (GDP-D-MANNOSE DEHYDRATASE) Mb0116, gca, len: 318 aa. Equivalent to Rv0112,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Possible gca,GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21,(27.0% identity in 318 aa overlap). Similar to Rv3634c,Rv3784, etc from Mycobacterium tuberculosis. Contains PS00061 Short-chain dehydrogenases/reductases family signature. SEEMS TO BELONG TO THE GDP-MANNOSE 4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+). Q7U2U2 No cell wall and cell processes Rv0112 NC_002945.3 Mycobrowser_v2 CDS 137357 137947 . + 0 Mb0117 gmhA probable sedoheptulose-7-phosphate isomerase gmha (phosphoheptose isomerase) Mb0117, gmhA, len: 196 aa. Equivalent to Rv0113,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable gmhA (alternate gene name: lpcA), phosphoheptose isomerase (EC 5.-.-.-), similar to many e.g. AE0005|HPAE000596_11 from Helicobacter pylori (192 aa), FASTA scores: opt: 451, E(): 1.9e-24, (45.1% identity in 162 aa overlap). BELONGS TO THE SIS FAMILY, LPCA SUBFAMILY. X2BE22,P0A605 No cell wall and cell processes Rv0113 NC_002945.3 Mycobrowser_v2 CDS 137979 138551 . + 0 Mb0118 gmhb possible d-alpha,beta-d-heptose-1,7-biphosphate phosphatase gmhb (d-glycero-d-manno-heptose 7-phosphate kinase) Mb0118, -, len: 190 aa. Equivalent to Rv0114, len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 190 aa overlap). Possible dehydratase (EC 4.-.-.-), similar to several hypothetical proteins and to HIS7_ECOLI|P06987 imidazoleglycerol-phosphate dehydratase (355 aa), FASTA scores: opt: 250, E(): 3.6e-11, (34.0 % identity in 141 aa overlap). X2BE37,Q7U2U1 No cell wall and cell processes Rv0114 NC_002945.3 Mycobrowser_v2 CDS 138702 139619 . + 0 Mb0119 hdda possible d-alpha-d-heptose-7-phosphate kinase hdda Mb0119, -, len: 305 aa. Equivalent to Rv0115, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(98.5% identity in 275 aa overlap). Possible sugar kinase (EC 2.-.-.-), similar to several hypothetical proteins and sugar kinases e.g. AAK27850.1|AF324836_3 D-glycero-D-manno-heptose 7-phosphate kinase from Aneurinibacillus thermoaerophilus (341 aa); AAK80995.1|AE007802_11 Sugar kinase from Clostridium acetobutylicum (364 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U2U0 No cell wall and cell processes Rv0115 NC_002945.3 Mycobrowser_v2 CDS 140307 141062 . - 0 Mb0120c ldta probable l,d-transpeptidase ldta Mb0120c, -, len: 251 aa. Equivalent to Rv0116c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Possible conserved membrane protein, showing similarity to several hypothetical mycobacterial proteins e.g. Rv1433 from Mycobacterium tuberculosis (271 aa); and Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa); to the C-terminal regions of others like Rv0192 from Mycobacterium tuberculosis (366 aa), FASTA scores: opt: 451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7% identity in 221 aa overlap). TBparse score is 0.932. Q7U2T9 No cell wall and cell processes Rv0116c NC_002945.3 Mycobrowser_v2 CDS 161060 161665 . + 0 Mb0138 gcn5-related n-acetyltransferase Mb0138, -, len: 201 aa. Equivalent to Rv0133, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Putative acetyltransferase (EC 2.3.1.-), highly similar to others e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 aa), FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity in 201 aa overlap). Q7U2S2 No intermediary metabolism and respiration Rv0133 NC_002945.3 Mycobrowser_v2 CDS 141240 142184 . + 0 Mb0121 oxyS OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN OXYS Mb0121, oxyS, len: 314 aa. Equivalent to Rv0117,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). OxyS, oxidative stress response protein regulatory protein, LysR family (see citation below). Similar to many transcription regulators and OxyR, the oxidative stress response protein of many bacteria. Contains LysR family signature at N-terminus. Also contains helix-turn-helix motif at aa 16-37 (Score 1543, +4.44 SD). BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. OXYR IS REQUIRED FOR THE INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES SUCH AS CATALASE, GLUTATHIONE-REDUCTASE, ETC. Q7U2T8 No regulatory proteins Rv0117 NC_002945.3 Mycobrowser_v2 CDS 142168 143916 . - 0 Mb0122c oxcA PROBABLE OXALYL-COA DECARBOXYLASE OXCA Mb0122c, oxcA, len: 582 aa. Equivalent to Rv0118c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 582 aa overlap). Probable oxcA,oxalyl-CoA decarboxylase (EC 4.1.1.8), highly similar to many e.g. P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 PROBABLE OXALYL-CoA DECARBOXYLASE from Escherichia coli (564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from Oxalobacter formigenes (568 aa), FASTA scores: opt: 2124,E():0, (55.6% identity in 568 aa overlap). Also similar to mycobacterial IlvB proteins e.g. MLCB1788.46c unknown TPP-requiring enzyme from Mycobacterium leprae (548 aa); and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa),FASTA scores: opt: 831, E(): 0, (33.9% identity in 567 aa overlap). Q7U2T7 No NC_002945.3 Mycobrowser_v2 CDS 1791019 1791366 . + 0 Mb1632 hisI Probable phosphoribosyl-AMP 1,6 cyclohydrolase hisI Mb1632, hisI, len: 115 aa. Equivalent to Rv1606,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Probable hisI,phosphoribosyl-AMP 1,6 cyclohydrolase (EC 3.5.4.19),similar to several e.g. X82010|RSHISI_2 HISI from Rhodobacter sphaeroides (119 aa), FASTA scores: opt: 378,E(): 2.8e-21, (52.3% identity in 109 aa overlap); etc. X2BIF1,P0A5B4 No intermediary metabolism and respiration Rv1606 NC_002945.3 Mycobrowser_v2 CDS 144089 145666 . + 0 Mb0123 fadD7 PROBABLE FATTY-ACID-COA LIGASE FADD7 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0123, fadD7, len: 525 aa. Equivalent to Rv0119,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable fadD7,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to 4-coumarate:CoA ligase of many organisms e.g. U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus taedaxylem (537 aa), FASTA scores: opt: 483, E(): 8.3e-22,(28.2% identity in 440 aa overlap). Contains PS00455 Putative AMP-binding domain signature. TBscore is 0.896. Q7U2T6 No NC_002945.3 Mycobrowser_v2 CDS 167461 167871 . - 0 Mb0146c unknown protein Mb0146c, -, len: 136 aa. Equivalent to Rv0141c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Hypothetical unknown protein. Q7U2R7 No conserved hypotheticals Rv0141c NC_002945.3 Mycobrowser_v2 CDS 152515 154320 . + 0 Mb0131 treS TREHALOSE SYNTHASE TRES Mb0131, treS, len: 601 aa. Equivalent to Rv0126,len: 601 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 601 aa overlap). treS, trehalose synthase (EC 5.4.99.-) (see citation below), highly similar to others e.g. CAA04601.2|AJ001205 putative trehalose synthase from Streptomyces coelicolor (566 aa); S71450|1536814|BAA11303.1|D78198 trehalose synthase maltose-specific from Pimelobacter sp. strain R48 (573 aa). Also similar to MAL1_DROME|P07191 possible maltase precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7% identity in 504 aa overlap); and similar to proteins associated with amino-acid transport e.g. Q64319 rat protein which stimulates transport of cystine and dibasic and neutral amino acids (683 aa), FASTA scores: opt: 839,E(): 0, (32.0% identity in 531 aa overlap). Also similar to several other Mycobacterium tuberculosis proteins e.g. Rv2471 FASTA score: (31.7% identity in 164 aa overlap). Q7U2S8 No virulence, detoxification, adaptation Rv0126 NC_002945.3 Mycobrowser_v2 CDS 154423 155790 . + 0 Mb0132 mak maltokinase mak Mb0132, -, len: 455 aa. Equivalent to Rv0127, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 455 aa overlap). Conserved hypothetical protein, highly similar to various proteins e.g. AJ0012|SCJ001205_4 hypothetical protein from Streptomyces coelicolor A3(2) (464 aa), FASTA scores: opt: 412, E(): 1.1e-19, (40.6% identity in 485 aa overlap); AJ0012|SCJ001206_5 hypothetical protein from Streptomyces coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E(): 4.3 e-19, (36.5% identity in 455 aa overlap). X2BE38,Q7U2S7 No virulence, detoxification, adaptation Rv0127 NC_002945.3 Mycobrowser_v2 CDS 145667 147460 . - 0 Mb0124c fusA2b PROBABLE ELONGATION FACTOR G FUSA2B [SECOND PART] (EF-G) Mb0124c, fusA2b, len: 597 aa. Equivalent to 3' end of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 597 aa overlap). Probable fusA2 (alternate gene name: fus2), elongation factor G,highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia coli (703 aa), FASTA scores: opt: 1049, E(): 0, (32.5% identity in 717 aa overlap). Also similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FASTA score: (39.1% identity in 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G (EF-G) from Mycobacterium leprae (701 aa), FASTA score: (31.7% identity in 710 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fusA2 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (gc-t), splits fusA2 into 2 parts, fusA2a and fusA2b. Q7U2T5 No NC_002945.3 Mycobrowser_v2 CDS 197852 198721 . + 0 Mb0174 yrbE1B conserved integral membrane protein yrbe1b Mb0174, yrbE1B, len: 289 aa. Equivalent to Rv0168,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). yrbE1B, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 223,E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc. Q7U2P0 No NC_002945.3 Mycobrowser_v2 CDS 250316 251794 . + 0 Mb0216 HYPOTHETICAL PROTEIN Mb0216, -, len: 492 aa. Equivalent to Rv0210, len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. Q7U2K2 No conserved hypotheticals Rv0210 NC_002945.3 Mycobrowser_v2 CDS 147457 147810 . - 0 Mb0125c fusA2a PROBABLE ELONGATION FACTOR G FUSA2A [FIRST PART] (EF-G) Mb0125c, fusA2a, len: 117 aa. Equivalent to 5' end of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 108 aa overlap). Probable fusA2 (alternate gene name: fus2), elongation factor G,highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia coli (703 aa), FASTA scores: opt: 1049, E(): 0, (32.5% identity in 717 aa overlap). Also similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FASTA score: (39.1% identity in 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G (EF-G) from Mycobacterium leprae (701 aa), FASTA score: (31.7% identity in 710 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fusA2 exists as a single gene. In Mycobacterium bovis, a frameshift due to the substitution of a single base (gc-t), splits fusA2 into 2 parts, fusA2a and fusA2b. Q7U2T4 No NC_002945.3 Mycobrowser_v2 CDS 147946 148380 . - 0 Mb0126c conserved protein Mb0126c, -, len: 144 aa. Equivalent to Rv0121c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Conserved hypothetical protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155,Rv1875, Rv2074, etc. Q7U2T3 No conserved hypotheticals Rv0121c NC_002945.3 Mycobrowser_v2 CDS 148529 148897 . + 0 Mb0127 HYPOTHETICAL PROTEIN Mb0127, -, len: 122 aa. Equivalent to Rv0122, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical unknown protein. Q7U2T2 No conserved hypotheticals Rv0122 NC_002945.3 Mycobrowser_v2 CDS 148894 149262 . + 0 Mb0128 unknown protein Mb0128, -, len: 122 aa. Equivalent to Rv0123, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical unknown protein. Q7U2T1 No conserved hypotheticals Rv0123 NC_002945.3 Mycobrowser_v2 CDS 149571 151187 . + 0 Mb0129 PE_PGRS2 pe-pgrs family protein pe_pgrs2 Mb0129, PE_PGRS2, len: 538 aa. Similar to Rv0124,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(87.4% identity in 547 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1730, E(): 0, (60.7% identity in 504 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa). Q7U2T0 No NC_002945.3 Mycobrowser_v2 CDS 151339 152406 . + 0 Mb0130 pepA probable serine protease pepa (serine proteinase) (mtb32a) Mb0130, pepA, len: 355 aa. Equivalent to Rv0125,len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 355 aa overlap). Probable pepA, serine protease (EC 3.4.21.-), highly similar to other proteases e.g. HHOB_ECOLI|P31137 protease hhob precursor (355 aa),FASTA scores: opt: 400, E(): 3.8e-14, (32.4% identity in 346 aa overlap). Also similar to Q50320 34 KDA protein precursor from Mycobacterium tuberculosis (361 aa), FASTA scores: opt: 1689, E(): 0, (70.7% identity in 362 aa overlap). Contains PS00135 Serine proteases, trypsin family, serine active site. Has a possible signal sequence at the N-terminus. Q7U2S9 No intermediary metabolism and respiration Rv0125 NC_002945.3 Mycobrowser_v2 CDS 156769 157791 . - 0 Mb0134c fbpC SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) Mb0134c, fbpC, len: 340 aa. Equivalent to Rv0129c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). fbpC (alternate gene names: mpt45, 85C, fbpC2), secreted antigen 85c (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below), also highly similar to other Mycobacterial antigen precursors e.g. A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1937,E(): 0, (81.4% identity in 333 aa overlap); etc. X2BE42,P0A4V5 No NC_002945.3 Mycobrowser_v2 CDS 158038 158493 . + 0 Mb0135 htdz probable 3-hydroxyl-thioester dehydratase Mb0135, -, len: 151 aa. Equivalent to Rv0130, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, most similar to AL096811|SCI30A_19 from Streptomyces coelicolor (153 aa), FASTA scores: opt: 639, E(): 0, (60.8% identity in 148 aa overlap). Also similar to NODN_RHILV|P08634 nodulation protein from Rhizobium leguminosarum bv. viciae plasmid pRL1JI (161 aa), FASTA scores: opt: 406, E(): 1e-21, (43.9% identity in 148 aa overlap; and to O30041 MONOAMINE OXIDASE REGULATORY PROTEIN (146 aa), FASTA scores: opt: 219, E(): 1.1e-08, (30.8% identity in 133 aa overlap). X2BE39,Q7U2S5 No intermediary metabolism and respiration Rv0130 NC_002945.3 Mycobrowser_v2 CDS 158506 159849 . - 0 Mb0136c fadE1 PROBABLE ACYL-CoA DEHYDROGENASE FADE1 Mb0136c, fadE1, len: 447 aa. Equivalent to Rv0131c,len: 447 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 447 aa overlap). Probable fadE1,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain specific precursor (412 aa), FASTA scores: opt: 522, E(): 1.4e-23, (30.1% identity in 425 aa overlap). Also highly similar to MTCI5_28 from Mycobacterium tuberculosis. Q7U2S4 No NC_002945.3 Mycobrowser_v2 CDS 159891 160973 . - 0 Mb0137c fgd2 putative f420-dependent glucose-6-phosphate dehydrogenase fgd2 Mb0137c, fgd2, len: 360 aa. Equivalent to Rv0132c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 360 aa overlap). Putative fgd2,F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), highly similar to many from Mycobacteria e.g. AAD38167|g5031431 from Mycobacterium chelonae. Also similar to MJ1534|Q58929 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE from METHANOCOCCUS JANNASCHII (342 aa), FASTA scores: opt: 285, E(): 7.9e-11,(28.4% identity in 292 aa overlap). And also similar to Rv0953c, Rv0791c, etc from Mycobacterium tuberculosis. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U2S3 No NC_002945.3 Mycobrowser_v2 CDS 163556 164881 . + 0 Mb0141 cyp138 PROBABLE CYTOCHROME P450 138 CYP138 Mb0141, cyp138, len: 441 aa. Equivalent to Rv0136,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable cyp138,cytochrome P450 138 (EC 1.14.-.-), similar to others e.g. SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 aa), FASTA scores: opt: 315, E(): 1e-13, (25.7% identity in 416 aa overlap); etc. Also similar to MTV039_6 from Mycobacterium tuberculosis (472 aa), FASTA score: (38.2% identity in 442 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BE52,P63718 No NC_002945.3 Mycobrowser_v2 CDS 164902 165450 . - 0 Mb0142c msrA PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) REDUCTASE) Mb0142c, msrA, len: 182 aa. Equivalent to Rv0137c,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable msrA,peptide methionine sulfoxide reductase (EC 1.8.4.6),equivalent to CAC32179.1|AL583926 putative peptide methionine sulfoxide from Mycobacterium leprae (177 aa). Highly similar to others e.g. CAC18703.1|AL451182 putative peptide methionine sulfoxide reductase from Streptomyces coelicolor (172 aa); PMSR_SCHPO|Q09859 putative peptide methionine sulfoxide reductase from Streptomyces (187 aa),FASTA scores: opt: 468, E(): 9.9e-26, (45.6% identity in 158 aa overlap); etc. BELONGS TO THE MSRA FAMILY. X2BE48,P0A5L1 No NC_002945.3 Mycobrowser_v2 CDS 165513 166016 . + 0 Mb0143 CONSERVED HYPOTHETICAL PROTEIN Mb0143, -, len: 167 aa. Equivalent to Rv0138, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 167 aa overlap). Conserved hypothetical protein, showing weak similarity to Q10827|YT10_MYCTU HYPOTHETICAL 17.0 KDA PROTEIN from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 131, E(): 0.047,(31.15% identity in 106 aa overlap). Q7U2S0 No conserved hypotheticals Rv0138 NC_002945.3 Mycobrowser_v2 CDS 166017 167039 . + 0 Mb0144 possible oxidoreductase Mb0144, -, len: 340 aa. Equivalent to Rv0139, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). Putative oxidoreductase (EC 1.-.-.-), similar to others e.g. O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa),FASTA scores: opt: 507, E (): 5.8e-27, (31.1% identity in 328 aa overlap); TRE_STRGR|P29782 dtdp-glucose 4,6-dehydratase (328 aa), FASTA scores: opt: 254, E(): 2.6e-10, (29.0% identity in 307 aa overlap). Q7U2R9 No intermediary metabolism and respiration Rv0139 NC_002945.3 Mycobrowser_v2 CDS 167100 167480 . + 0 Mb0145 conserved protein Mb0145, -, len: 126 aa. Equivalent to Rv0140, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Conserved hypothetical protein, similar to others e.g. P74567|D90916_48 HYPOTHETICAL 20.8 KDP ROTEIN from Synechocystis sp. (180 aa), FASTA scores: opt: 229, E(): 4.7e-10, (36.1% identity in 108 aa overlap). Also similar to Rv1056 and Rv1670 from Mycobacterium tuberculosis. Q7U2R8 No conserved hypotheticals Rv0140 NC_002945.3 Mycobrowser_v2 CDS 168894 170372 . - 0 Mb0148c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0148c, -, len: 492 aa. Equivalent to Rv0143c,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Probable conserved transmembrane protein, CIC family possibly involved in transport of chloride, similar to others and hypothetical proteins e.g. O28857 PUTATIVE CHLORIDE CHANNEL from Archaeoglobus fulgidus (589 aa), FASTA scores: opt: 966,E(): 0, (37.7% identity in 453 aa overlap); YADQ_ECOLI|P37019 hypothetical 46.0 kd protein (436 aa),FASTA scores: opt: 452, E(): 2.4e-20, (28.0% identity in 460 aa overlap). Q7U2R5 No cell wall and cell processes Rv0143c NC_002945.3 Mycobrowser_v2 CDS 249234 250319 . + 0 Mb0215 HYPOTHETICAL PROTEIN Mb0215, -, len: 361 aa. Equivalent to Rv0209, len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 361 aa overlap). Hypothetical unknown protein. Q7U2K3 No conserved hypotheticals Rv0209 NC_002945.3 Mycobrowser_v2 CDS 170474 171316 . + 0 Mb0149 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0149, -, len: 280 aa. Equivalent to Rv0144, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable transcriptional regulator, possibly tetR family. Has region similar to others e.g. Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli strains K12 and O157:H7 (196 aa), FASTA scores: opt: 214, E(): 1.1e-06, (26.0% identity in 196 aa overlap). Contains probable helix-turn helix motif from aa 109-130 (Score 1463, +4.17 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U2R4 No regulatory proteins Rv0144 NC_002945.3 Mycobrowser_v2 CDS 173428 174948 . + 0 Mb0152 probable aldehyde dehydrogenase (nad+) dependent Mb0152, -, len: 506 aa. Equivalent to Rv0147, len: 506 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 506 aa overlap). Probable aldehyde dehydrogenase (NAD+) dependant (EC 1.2.1.-), similar to others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric NADP-preferring) (452 aa), FASTA scores: opt: 1291, E(): 0, (43.9% identity in 453 aa overlap). Also similar to several Mycobacterium tuberculosis aledehyde dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 aldehyde dehydrogenases glutamic acid active site, and PS00070 aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Q7U2R1 No intermediary metabolism and respiration Rv0147 NC_002945.3 Mycobrowser_v2 CDS 175023 175883 . + 0 Mb0153 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb0153, -, len: 286 aa. Equivalent to Rv0148, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable short-chain dehydrogenase (EC 1.-.-.-), similar to others, in particular Estradiol 17 beta-dehydrogenases (EC 1.1.1.62),e.g. DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 (735 aa), FASTA scores: opt: 952, E(): 0, (52.5% identity in 276 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U2R0 No intermediary metabolism and respiration Rv0148 NC_002945.3 Mycobrowser_v2 CDS 175890 176858 . + 0 Mb0154 possible quinone oxidoreductase (nadph:quinone oxidoreductase) (zeta-crystallin) Mb0154, -, len: 322 aa. Equivalent to Rv0149, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 322 aa overlap). Putative quinone oxidoreductase (EC 1.6.5.-), similar to others oxidoreductases e.g. Q08257 quinone oxidoreductase (EC 1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18,(28.4% identity in 328 aa overlap); SCHCOADH_4 from Streptomyces coelicolor. Also similar to many proteins from Mycobacterium tuberculosis. Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. BELONG TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. Q7U2Q9 No intermediary metabolism and respiration Rv0149 NC_002945.3 Mycobrowser_v2 CDS 176855 177142 . - 0 Mb0155c CONSERVED HYPOTHETICAL PROTEIN Mb0155c, -, len: 95 aa. Equivalent to Rv0150c, len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 95 aa overlap). Conserved hypothetical protein, showing some similarity with C-terminus of O53949|Rv1800|MTV049.22 PPE-FAMILY PROTEIN from Mycobacterium tuberculosis (655 aa), FASTA score: (36.5% identity in 104 aa overlap). Q7U2Q8 No conserved hypotheticals Rv0150c NC_002945.3 Mycobrowser_v2 CDS 209895 211004 . - 0 Mb0185c lprO possible lipoprotein lpro Mb0185c, lprO, len: 369 aa. Equivalent to Rv0179c,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 369 aa overlap). Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U2M9 No NC_002945.3 Mycobrowser_v2 CDS 177733 179499 . - 0 Mb0156c PE1 pe family protein pe1 Mb0156c, PE1, len: 588 aa. Equivalent to Rv0151c,len: 588 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 588 aa overlap). Member of the Mycobacterium tuberculosis PE family, with N-terminal region similar to others e.g. MTV032_2 PE_PGRS family from Mycobacterium tuberculosis (468 aa), FASTA scores: opt: 1125, E(): 0, (46.3% identity in 456 aa overlap); MTCY493_24 from M. tuberculosis FASTA score: (42.5% identity in 558 aa overlap). Also similar to upstream ORF MTCI5.26c FASTA score: (54.7% identity in 464 aa overlap). Also shows similarity to C-terminal part of some PPE family proteins e.g. MTV049_21 from Mycobacterium tuberculosis FASTA score: (41.5% identity in 591 aa overlap). Q7U2Q7 No NC_002945.3 Mycobrowser_v2 CDS 179509 181086 . - 0 Mb0157c PE2 pe family protein pe2 Mb0157c, PE2, len: 525 aa. Equivalent to Rv0152c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to ORF downstream Z92770|MTCI5_25 (588 aa), FASTA scores: opt: 1492, E(): 0, (54.7% identity in 464 aa overlap); and to many other PE family type members. Q7U2Q6 No NC_002945.3 Mycobrowser_v2 CDS 181345 182175 . - 0 Mb0158c ptbB PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) Mb0158c, ptbB, len: 276 aa. Equivalent to Rv0153c,len: 276 aa, from Mycobacterium tuberculosis strain H27Rv,(99.6% identity in 276 aa overlap). ptbB (alternate gene name: MPtpB), protein-tyrosine-phosphatase (see citation below) (EC 3.1.3.48), showing some similarity to several protein-tyrosine phosphatases, polyketide synthase and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed a secreted protein. Q7U2Q5 No NC_002945.3 Mycobrowser_v2 CDS 182177 183388 . - 0 Mb0159c fadE2 PROBABLE ACYL-CoA DEHYDROGENASE FADE2 Mb0159c, fadE2, len: 403 aa. Equivalent to Rv0154c,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 403 aa overlap). Probable fadE2,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. C-terminal region of O01590 ACYL-CoA DEHYDROGENASE (974 aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain) (383 aa), FASTA score: (35.0% identity in 306 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7U2Q4 No NC_002945.3 Mycobrowser_v2 CDS 183812 184912 . + 0 Mb0160 pntAa PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAa [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) Mb0160, pntAa, len: 366 aa. Equivalent to Rv0155,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 366 aa overlap). Probable pntAa, first part of NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2), similar to N-terminus of others e.g. PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase subunit alpha from Escherichia coli strain K12 (510 aa),FASTA scores: opt: 921, E(): 0, (42.1% identity in 361 aa overlap); PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA (EC 1.6.1.1). Q7U2Q3 No NC_002945.3 Mycobrowser_v2 CDS 184913 185245 . + 0 Mb0161 pntAb PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAb [SECOND PART; INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) Mb0161, pntAb, len: 110 aa. Equivalent to Rv0156,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 110 aa overlap). Probable pntAb, second part of NAD(P) transhydrogenase subunit alpha, integral membrane protein, similar to C-terminus of others e.g. Q59764 NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAB (139 aa), FASTA scores: opt: 247, E(): 1.9e-11,(45.5% identity in 88 aa overlap). Q7U2Q2 No NC_002945.3 Mycobrowser_v2 CDS 185242 186669 . + 0 Mb0162 pntB PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) Mb0162, pntB, len: 475 aa. Equivalent to Rv0157,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 475 aa overlap). Probable pntB,pyridine nucleotide transhydrogenase (nicotinamide nucleotide transhydrogenase) subunit beta (EC 1.6.1.1),integral membrane protein, similar to others e.g. Q59763 PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity in 472 aa overlap); P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli strains K12 and O157:H7 (462 aa). Q7U2Q1 No intermediary metabolism and respiration Rv0157 NC_002945.3 Mycobrowser_v2 CDS 186685 186813 . - 0 Mb0162A Conserved protein Mb0162A, len: 42 aa. Equivalent to Rv0157A len: 42 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 42 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein,showing similarity to C-terminal part (aa 186-220) of O53976|Rv1975|MTV051.13 conserved hypothetical protein from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 173, E(): 3e-06, (62.5% identity in 40 aa overlap). X2BE85 No conserved hypotheticals Rv0157A NC_002945.3 Mycobrowser_v2 CDS 186975 187619 . + 0 Mb0163 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0163, -, len: 214 aa. Equivalent to Rv0158, len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable transcriptional regulator, possibly TetR family, showing weak similarity to various transcriptional activators and repressors e.g. P32398|YIXD_BACSU|YHGD HYPOTHETICAL TRANSCRIPTIONAL REGULATORY PROTEIN from Bacillus subtilis (191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0% identity in 191 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1296, +3.60 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U2Q0 No regulatory proteins Rv0158 NC_002945.3 Mycobrowser_v2 CDS 187623 189029 . - 0 Mb0164c PE3 pe family protein pe3 Mb0164c, PE3, len: 468 aa. Equivalent to Rv0159c,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 468 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many other PE proteins e.g. O06828 from Mycobacterium tuberculosis (528 aa), FASTA scores: opt: 1163, E(): 0,(45.8% identity in 467 aa overlap). Also highly similar to upstream MTV032_3, and to MTCI5_25, MTCI5_26, MTV049_ 21,MTCY1A10_26, etc. Q7U2P9 No NC_002945.3 Mycobrowser_v2 CDS 189121 190629 . - 0 Mb0165c PE4 pe family protein pe4 Mb0165c, PE4, len: 502 aa. Equivalent to Rv0160c,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 502 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many other PE proteins e.g. Z92770|MTCI5_26c from M. tuberculosis (525 aa), FASTA scores: opt: 816, E(): 0,(41.4% identity in 367 aa overlap); C-terminal region of O06801|RV1768|MTCY28.34 from Mycobacterium tuberculosis (618 aa), FASTA scores: opt: 417, E(): 6.7e-18, (53.5% identity in 142 aa overlap). Also highly similar to downstream ORF MTV032_2. Q7U2P8 No NC_002945.3 Mycobrowser_v2 CDS 190797 192146 . + 0 Mb0166 possible oxidoreductase Mb0166, -, len: 449 aa. Equivalent to Rv0161, len 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 actin interacting protein 2 (530 aa),FASTA scores: opt: 356, E (): 0, (33.3% identity in 357 aa overlap); DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome) (587 aa), FASTA scores: opt: 311, E(): 2.5e-20, (27.9% identity in 366 aa overlap). Also similar to other Mycobacteria proteins e.g. MTCY339.30c from M. tuberculosis FASTA score: (29.4% identity in 357 aa overlap); MLCL622.30c from Mycobacterium tuberculosis (449 aa). Q7U2P7 No intermediary metabolism and respiration Rv0161 NC_002945.3 Mycobrowser_v2 CDS 211084 212442 . - 0 MbXXXXc Mb0186c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN MbXXXXc -, len: 452 aa. Equivalent to Rv0180c, len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 452 aa overlap). Probable conserved transmembrane protein, equivalent to CAC32132.1|AL583926 probable conserved membrane protein from Mycobacterium leprae (465 aa). Shows some similarity with others membrane proteins e.g. AL096849|SCI11_29 from Streptomyces coelicolor (354 aa), FASTA scores: opt: 190, E(): 0.00067,(25.9% identity in 409 aa overlap). Q7U2M8 No cell wall and cell processes Rv0180c NC_002945.3 Mycobrowser_v2 CDS 192174 193325 . - 0 Mb0167c adhE1 probable zinc-type alcohol dehydrogenase (e subunit) adhe1 Mb0167c, adhE1, len: 383 aa. Equivalent to Rv0162c,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Probable adhE1,zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7% identity in 363 aa overlap). Also similar to other alcohol dehydrogenases from Mycobacterium tuberculosis e.g. MTCY369.06c FASTA score: (34.0% identity in 365 aa overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa overlap). Contains PS00059 Zinc-contain ingalcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR: ZINC. Q7U2P6 No NC_002945.3 Mycobrowser_v2 CDS 193307 193762 . + 0 Mb0168 conserved protein Mb0168, -, len: 151 aa. Equivalent to Rv0163, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, similar to others e.g. Q44017 HYPOTHETICAL 16.6 KDA PROTEIN IN GBD 5'REGION (ORF6)from Alcaligenes eutrophus (145 aa), FASTA scores: opt: 155,E(): 0.0002, (26.6% identity in 139 aa overlap). Also weak similary with MTV008.31c|Rv2475c|B70867 from Mycobacterium tuberculosis (138 aa). Q7U2P5 No conserved hypotheticals Rv0163 NC_002945.3 Mycobrowser_v2 CDS 197053 197850 . + 0 Mb0173 yrbE1A conserved integral membrane protein yrbe1a Mb0173, yrbE1A, len: 265 aa. Equivalent to Rv0167,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). yrbE1A, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar or similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa),FASTA scores: opt: 328, E(): 1.8e-15, (26.6% identity in 244 aa overlap); etc. Q7U2P1 No NC_002945.3 Mycobrowser_v2 CDS 207006 207647 . + 0 Mb0181 PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN Mb0181, -, len: 213 aa. Equivalent to Rv0175, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Probable conserved Mce-associated membrane protein, equivalent, but longer in N-terminus, to CAC32127.1|AL583926 possible membrane protein from Mycobacterium leprae (182 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Contains two 12 residue direct repeats at N-terminus. Q7U2N3 No cell wall and cell processes Rv0175 NC_002945.3 Mycobrowser_v2 CDS 194315 195007 . - 0 Mb0170c mce1R Probable transcriptional regulatory protein Mce1R (probably GntR-family) Mb0170c, len: 230 aa. Equivalent to Rv0165c len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(81.2% identity in 218 aa overlap). Probable mce1R,transcriptional regulator, GntR family (See Casali et al.,2006), showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI gluconate operon transcriptional repressor from Bacillus licheniformis (243 aa); GNTR_BACSU gluconate operon repressor from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. Seems to belong to the GntR family of transcriptional regulators. Start changed since first submission (-41 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus. X2BE70 No regulatory proteins Rv0165c NC_002945.3 Mycobrowser_v2 CDS 194334 194513 . - 0 Mb0171c mce1r POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0171c, -, len: 59 aa. Equivalent to 3' end of Rv0165c, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 57 aa overlap). Possible transcriptional regulator, GntR family, showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH part. Mb0171c corresponds to the remnant COOH part of Rv0165c. No NC_002945.3 Mycobrowser_v2 CDS 195185 196849 . + 0 Mb0172 fadD5 PROBABLE FATTY-ACID-CoA LIGASE FADD5 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Mb0172, fadD5, len: 554 aa. Equivalent to Rv0166,len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 554 aa overlap). Probable fadD5,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many eg LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in 534 aa overlap). Also similar to many other fatty-acid-CoA ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c FASTA score: (35.3% identity in 487 aa overlap),MTV013_10, MTY25D10_30, etc. Contains PS00455 putative AMP-binding domain signature. Q7U2P2 No NC_002945.3 Mycobrowser_v2 CDS 212469 213203 . - 0 Mb0187c CONSERVED HYPOTHETICAL PROTEIN Mb0187c, -, len: 244 aa. Equivalent to Rv0181c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd protein from Escherichia coli (231 aa), FASTA scores: opt: 479, E(): 1.2e-29, (37.3% identity in 233 aa overlap); P73623|SLL1773 HYPOTHETICAL 25.7 KD PROTEIN from Synechocystis sp. strain PCC 6803 (232 aa), FASTA score: (39.1% identity in 233 aa overlap). X2BEB5,P65725 No conserved hypotheticals Rv0181c NC_002945.3 Mycobrowser_v2 CDS 198726 200090 . + 0 Mb0175 mce1A MCE-FAMILY PROTEIN MCE1A Mb0175, mce1A, len: 454 aa. Equivalent to Rv0169,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 454 aa overlap). mce1A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene product from Mycobacterium avium (88 aa) (similarity on C-terminus); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Note that equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 Mcep protein from Mycobacterium tuberculosis (432 aa). Contains a very hydrophobic region around residues 20-35. Note that previously known as mce1. Q7U2N9 No NC_002945.3 Mycobrowser_v2 CDS 200087 201127 . + 0 Mb0176 mce1B MCE-FAMILY PROTEIN MCE1B Mb0176, mce1B, len: 346 aa. Equivalent to Rv0170,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 346 aa overlap). mce1B (alternate gene name: mceD); belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa); etc. Contains hydrophobic region in N-terminal 30 residues. In Escherichia coli, N-terminal part is functional and directs export of a leaderless beta-lactamase into the periplasm (see seventh citation). Q7U2N8 No NC_002945.3 Mycobrowser_v2 CDS 201124 202671 . + 0 Mb0177 mce1C MCE-FAMILY PROTEIN MCE1C Mb0177, mce1C, len: 515 aa. Equivalent to Rv0171,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). mce1C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Weakly similar to downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA score: (24.6% identity in 552 aa overlap). Contains possible signal sequence and highly proline-rich C-terminus. Q7U2N7 No NC_002945.3 Mycobrowser_v2 CDS 219678 220109 . + 0 Mb0194 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0194, -, len: 143 aa. Equivalent to Rv0188, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Probable conserved transmembrane protein, similar to T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable membrane protein from Streptomyces coelicolor (147 aa),FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity in 141 aa overlap); N-terminus of P80185|MTRC_METTH TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT C (EC 2.1.1.86) from Methanobacterium thermoautotrophicum strain Marburg/DSM 2133 (266 aa), FASTA scores: opt: 125, E(): 0.033, (31.6% identity in 98 aa overlap). Also similar to Rv3635 from Mycobacterium tuberculosis. Q7U2M1 No cell wall and cell processes Rv0188 NC_002945.3 Mycobrowser_v2 CDS 207644 208612 . + 0 Mb0182 PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE PROTEIN Mb0182, -, len: 322 aa. Equivalent to Rv0176, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 322 aa overlap). Probable conserved Mce-associated transmembrane protein. Contains short region of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 kDa antigen) from Mycobacterium leprae (249 aa) (outside the proline-rich region), FASTA scores: opt: 165, E(): 2.9e-05, (40.0% identity in 65 aa overlap). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv3493c, etc. Q7U2N2 No cell wall and cell processes Rv0176 NC_002945.3 Mycobrowser_v2 CDS 202668 204260 . + 0 Mb0178 mce1D MCE-FAMILY PROTEIN MCE1D Mb0178, mce1D, len: 530 aa. Equivalent to Rv0172,len: 530 aa, fromMycobacterium tuberculosis strain H37Rv,(100.0% identity in 530 aa overlap). mce1D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Hydrophobic region at N-terminus. Q7U2N6 No NC_002945.3 Mycobrowser_v2 CDS 242172 243455 . - 0 Mb0210c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0210c, -, len: 427 aa. Equivalent to Rv0204c,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 412 aa overlap). Probable conserved transmembrane protein, equivalent, but has C-terminal extension, to Z95398|MLCL622.17c from Mycobacterium leprae (367 aa), FASTA scores: opt: 2002, E(): 0, (82.4% identity in 374 aa overlap). Some similarity to Rv0585c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 a versus 412 aa). Q7U2K7 No cell wall and cell processes Rv0204c NC_002945.3 Mycobrowser_v2 CDS 204257 205429 . + 0 Mb0179 lprK POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E) Mb0179, lprK, len: 390 aa. Equivalent to Rv0173,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Possible lprK (alternate gene name: mce1E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains PS00013 prokaryotic membrane lipoprotein lipid attachment site. Q7U2N5 No cell wall and cell processes Rv0173 NC_002945.3 Mycobrowser_v2 CDS 205423 206970 . + 0 Mb0180 mce1F MCE-FAMILY PROTEIN MCE1F Mb0180, mce1F, len: 515 aa. Equivalent to Rv0174,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). mce1F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Has hydrophobic stretch, possibly a signal peptide at the N-terminus. Q7U2N4 No NC_002945.3 Mycobrowser_v2 CDS 208609 209163 . + 0 Mb0183 PROBABLE CONSERVED MCE ASSOCIATED PROTEIN Mb0183, -, len: 184 aa. Equivalent to Rv0177, len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Probable conserved Mce-associated protein, equivalent to CAC32129.1|AL583926 conserved membrane protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv1973, Rv3493c,etc. Q7U2N1 No conserved hypotheticals Rv0177 NC_002945.3 Mycobrowser_v2 CDS 209130 209864 . + 0 Mb0184 PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN Mb0184, -, len: 244 aa. Equivalent to Rv0178, len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable conserved Mce-associated membrane protein, highly similar in C-terminus to CAC32130.1|AL583926 putative secreted protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10 aa overlap with the upstream ORF. Q7U2N0 No cell wall and cell processes Rv0178 NC_002945.3 Mycobrowser_v2 CDS 213220 214332 . - 0 Mb0188c sigG PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR) Mb0188c, sigG, len: 370 aa. Equivalent to Rv0182c,len: 370 aa (start site uncertain; first of several possibles was chosen, but note that this overlaps the upstream ORF), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 370 aa overlap). Probable sigG,alternative RNA polymerase sigma subunit (see citations below), similar to many e.g. Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FACTOR from Bacillus subtilis (187 aa). Also similar to nine other ECF sigma factors from Mycobacterium tuberculosis e.g. Rv1221, Rv0735, etc. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 205-226 (Score 1181, +3.21 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY,ECF SUBFAMILY. Q7U2M7 No NC_002945.3 Mycobrowser_v2 CDS 214280 215119 . + 0 Mb0189 POSSIBLE LYSOPHOSPHOLIPASE Mb0189, -, len: 279 aa. Equivalent to Rv0183, len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Possible lysophospholipase (EC 3.1.-.-), similar to several (especially eukaryotic enzymes, weaker with Escherichia coli), e.g. U67963|HSU67963_1 Human lysophospholipase homolog from Homo sapiens (313 aa), FASTA scores: opt: 569, E(): 2.6e-29, (37.1% identity in 259 aa overlap); P07000|PLDB_ECOLI LYSOPHOSPHOLIPASE L2 from Escherichia coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start changed based on similarity to AE001997_8 from Deinococcus radiodurans (282 aa), FASTA scores: opt: 510, E(): 1.4e-25, (34.8% identity in 282 aa overlap). Also shows some similarity to epoxide hydrolases from Mycobacterium tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in 114 aa overlap); and O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa). Note that the putative product of this CDS corresponds to spot 3_329 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). Q7U2M6 No intermediary metabolism and respiration Rv0183 NC_002945.3 Mycobrowser_v2 CDS 215161 215910 . + 0 Mb0190 CONSERVED HYPOTHETICAL PROTEIN Mb0190, -, len: 249 aa. Equivalent to Rv0184, len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Conserved hypothetical protein, equivalent to CAC32136.1|AL583926 conserved hypothetical protein from Mycobacterium lepra (249 aa); and C-terminus highly similar to CAB08793.1|Z95398 conserved hypothetical protein from Mycobacterium leprae (145 aa), FASTA scores: E(): 0, (75.2 identity in 145 aa overlap). Also similar to 049841|SCE9_39|T36358 hypothetical protein from Streptomyces coelicolor (418 aa), FASTA scores: opt: 231,E(): 8.1e-08, (30.4% identity in 270 aa overlap). Q7U2M5 No conserved hypotheticals Rv0184 NC_002945.3 Mycobrowser_v2 CDS 215907 216416 . + 0 Mb0191 CONSERVED HYPOTHETICAL PROTEIN Mb0191, -, len: 169 aa. Equivalent to Rv0185, len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Conserved hypothetical protein, equivalent to CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in 165 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q7U2M4 No conserved hypotheticals Rv0185 NC_002945.3 Mycobrowser_v2 CDS 216461 218536 . + 0 Mb0192 bglS PROBABLE BETA-GLUCOSIDASE BGLS (GENTIOBIASE) (CELLOBIASE) (BETA-D-GLUCOSIDE GLUCOHYDROLASE) Mb0192, bglS, len: 691 aa. Equivalent to Rv0186,len: 691 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 691 aa overlap). Probable bglS,beta-glucosidase (EC 3.2.1.21), highly similar to many e.g. BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0,(32.5% identity in 842 aa overlap). SEEMS TO BELONG TO FAMILY 3 OF GLYCOSYL HYDROLASES. Q7U2M3 No intermediary metabolism and respiration Rv0186 NC_002945.3 Mycobrowser_v2 CDS 218582 218743 . - 0 Mb0192A mymT Metallothionein, MymT Mb0192A, len: 53 aa. Equivalent to Rv0186A len: 53 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 53 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). MymT,metallothionein,equivalent to MAV_4993|A0QMH5 hypothetical protein from Mycobacterium avium (strain 104) (51 aa), and MAP_3626c|Q73TU2 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (51 aa), FASTA scores: opt: 312, E(): 4.6e-17, (81.2% identity in 48 aa overlap). X2BEB8 No virulence, detoxification, adaptation Rv0186A NC_002945.3 Mycobrowser_v2 CDS 218897 219559 . + 0 Mb0193 PROBABLE O-METHYLTRANSFERASE Mb0193, -, len: 220 aa. Equivalent to Rv0187, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable O-methyltransferase (EC 2.1.1.-), similar to many e.g. AB93458.1|AL357591 putative O-methyltransferase from Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719 O-methyltransferase from Streptomyces mycarofaciens (221 aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity in 192 aa overlap). Also similar to Rv1703c, Rv1220c from Mycobacterium tuberculosis. Q7U2M2 No intermediary metabolism and respiration Rv0187 NC_002945.3 Mycobrowser_v2 CDS 220188 221915 . - 0 Mb0195c ilvD PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) Mb0195c, ilvD, len: 575 aa. Equivalent to Rv0189c,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 575 aa overlap). Probable ilvD,dihydroxy-acid dehydratase (EC 4.2.1.9), similar to many e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (570 aa), FASTA scores: opt: 1605, E(): 0, (46.0% identity in 561 aa overlap). Also similar to ML2608|MLCL622.06c|O06069|ILVD_MYCLE DIHYDROXY-ACID DEHYDRATASE from Mycobacterium leprae (564 aa). Contains PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. BELONGS TO THE ILVD / EDD FAMILY. COFACTOR: BINDS 1 4FE-4S CLUSTER (POTENTIAL). X2BEA6,P65155 No NC_002945.3 Mycobrowser_v2 CDS 222481 223722 . + 0 Mb0197 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0197, -, len: 413 aa. Equivalent to Rv0191, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug,similar to several hypothetical proteins e.g. YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from Escherichia coli (396 aa), FASTA scores: opt: 475, E(): 4.2e-33, (29.7% identity in 381 aa overlap); and to several chloramphenicol resistance proteins e.g. CMLR_STRLI|P31141 chloramphenicol resistance protein from stremtomyces lividans (392 aa), FASTA scores: opt: 394,E(): 6.7e-12, (28.2% identity in 383 aa overlap). Also similar to SVU09991_1 from Mycobacterium tuberculosis. Q7U2L9 No cell wall and cell processes Rv0191 NC_002945.3 Mycobrowser_v2 CDS 223799 224857 . + 0 Mb0198 conserved secreted protein Mb0198, -, len: 352 aa. Equivalent to Rv0192 and Rv0192A, len: 366 aa and 100 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 318 aa overlap and 91.1% identity in 56 aa overlap). Conserved hypothetical protein. Has Gly- Arg-rich region followed by highly Pro-rich repetitive region near N-terminus. Similar in C-terminus to other hypothetical proteins e.g. Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09 hypothetical 47.9 kd protein from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 330, E(): 3.2e-13, (35.1% identity in 271 aa overlap). Also similar to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium tuberculosis. Probable N-terminal part of Rv0192, which is member of family P5.17 with Rv0116c, Rv1433, Rv2518c,Rv0483. These are all predicted to be exported/membrane proteins. Rv0192A has typical N-terminal signal peptide which is functional and was identified by PhoA fusion screens: O52054 PGB14T-O1 PRECURSOR (FRAGMENT 45 AA) (see citation below). Since Rv0192 misses a signal peptide this suggests that there is a frameshift in the region of the overlap with Rv0192 but none found on reinspection of sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Q7U2L8 No conserved hypotheticals Rv0192 NC_002945.3 Mycobrowser_v2 CDS 224917 226764 . - 0 Mb0199c HYPOTHETICAL PROTEIN Mb0199c, -, len: 615 aa. Equivalent to Rv0193c,len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 615 aa overlap). Hypothetical unknown protein. Q7U2L7 No conserved hypotheticals Rv0193c NC_002945.3 Mycobrowser_v2 CDS 227071 230655 . + 0 Mb0200 probable transmembrane multidrug efflux pump Mb0200, -, len: 1194 aa. Equivalent to Rv0194, len: 1194 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 1194 aa overlap). Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), highly similar to many e.g. U62129|STU62129_2|T30293 ABC transport protein homolog from Salmonella typhi (1218 aa), FASTA scores: opt: 1116, E(): 0, (36.3% identity in 1209 aa overlap); CAB66302.1|AL136519 ABC transporter protein ATP-binding component from Streptomyces coelicolor (1243 aa); I84547 mdl protein from Escherichia coli (1143 aa); etc. Also similar to MTCY50_9 and MTCY50_10 from Mycobacterium tuberculosis, FASTA score: (33.8% identity in 574 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop) and one PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Alternative start possible at 1823 but no RBS. Q7U2L6 No cell wall and cell processes Rv0194 NC_002945.3 Mycobrowser_v2 CDS 231093 231728 . + 0 Mb0201 possible two component transcriptional regulatory protein (probably luxr-family) Mb0201, -, len: 211 aa. Equivalent to Rv0195, len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Putative two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 SD). Q7U2L5 No regulatory proteins Rv0195 NC_002945.3 Mycobrowser_v2 CDS 231841 232425 . + 0 Mb0202 possible transcriptional regulatory protein Mb0202, -, len: 194 aa. Equivalent to Rv0196, len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 194 aa overlap). Putative transcriptional regulatory protein, similar to two Bacillus subtilis regulators: P42105|YXAF_BACSU HYPOTHETICAL 21.0 KD PROTEIN (191 aa), FASTA scores: opt: 323, E(): 2.1e-15, (30.9% identity in 181 aa overlap); and Z99105|BSUB0002_9 negative regulator of the lincomycin operon (188 aa), FASTA scores: opt: 255, E(): 1e-10, (25.9 identity in 185 aa overlap). Q7U2L4 No regulatory proteins Rv0196 NC_002945.3 Mycobrowser_v2 CDS 584852 585841 . - 0 Mb0504c conserved protein Mb0504c, -, len: 329 aa. Equivalent to Rv0493c,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 329 aa overlap). Conserved hypothetical protein, showing some similarity to U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa), FASTA scores: opt: 166, E(): 0.00077, (35.9% identity in 131 aa overlap). Q7U1W4 No conserved hypotheticals Rv0493c NC_002945.3 Mycobrowser_v2 CDS 232425 234671 . + 0 Mb0203 POSSIBLE OXIDOREDUCTASE Mb0203, -, len: 748 aa. Equivalent to Rv0197, len: 762 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 748 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to others e.g. 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin oxidoreductase from Pseudomonas aeruginosa strain PAO1 (769 aa); 5441785|CAB46809.1|AL096811|T36812 probable dehydrogenase from Streptomyces coelicolor (747 aa), FASTA scores: opt: 617, E(): 9.8e-30, (29.9% identity in 762 aa overlap); BAB04334.1|AP001509 assimilatory nitrate reductase (catalytic subunit) from Bacillus halodurans (743 aa); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (t-g) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Q7U2L3 No intermediary metabolism and respiration Rv0197 NC_002945.3 Mycobrowser_v2 CDS 234712 236703 . - 0 Mb0204c zmp1 probable zinc metalloprotease zmp1 Mb0204c, -, len: 663 aa. Equivalent to Rv0198c,len: 663 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 663 aa overlap). Probable zinc metalloprotease (EC 3.4.24.-), equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa),FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 aa overlap). Also similar to many other metalloproteases e.g. members of the eukaryotic neprilysin family: P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA scores: opt: 872, E(): 0, (31.1% identity in 692 aa overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): 0, (30.0% identity in 654 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY. Q7U2L2 No intermediary metabolism and respiration Rv0198c NC_002945.3 Mycobrowser_v2 CDS 236746 237405 . + 0 Mb0205 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0205, -, len: 219 aa. Equivalent to Rv0199, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Probable conserved membrane protein, equivalent to Z95398|MLCL622.13 from Mycobacterium leprae (224 aa), FASTA scores: opt: 920,E(): 0, (67.7% identity in 220 aa overlap). Also some similarity to Mce-associated membrane proteins from Mycobacterium tuberculosis e.g. Rv0178, Rv0175, etc. Q7U2L1 No cell wall and cell processes Rv0199 NC_002945.3 Mycobrowser_v2 CDS 237402 238091 . + 0 Mb0206 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0206, -, len: 229 aa. Equivalent to Rv0200, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Possible conserved transmembrane protein, equivalent to Z95398|MLCL622.14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1147, E(): 0, (74.7% identity in 229 aa overlap). Also some similarity to Rv1973 from Mycobacterium tuberculosis (160 aa); and Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA scores: opt: 134, E(): 0.063, (25.8% identity in 159 aa overlap). Q7U2L0 No cell wall and cell processes Rv0200 NC_002945.3 Mycobrowser_v2 CDS 238588 241488 . - 0 Mb0208c mmpL11 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11 Mb0208c, mmpL11, len: 966 aa. Equivalent to Rv0202c, len: 966 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 966 aa overlap). Probable mmpL11, conserved transmembrane transport protein (see citation below), equivalent to Z95398|MLCL622.16c from Mycobacterium leprae (1014 aa), FASTA scores: opt: 4076, E(): 0, (72.8% identity in 1017 aa overlap). Member of RND superfamily, similar to several putative transport proteins e.g. P96687 from Bacillus subtilis (724 aa),FASTA scores: opt: 594, E(): 9.1e-29, (26.9% identity in 717 aa overlap); etc. BELONGS TO THE MMPL FAMILY. X2BED8,P65375 No cell wall and cell processes Rv0202c NC_002945.3 Mycobrowser_v2 CDS 243580 244683 . + 0 Mb0211 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0211, -, len: 367 aa. Equivalent to Rv0205, len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 367 aa overlap). Possible conserved transmembrane protein, similar to hypothetical proteins from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces coelicolor (402 aa), FASTA scores: opt: 436, E(): 1.7e-21,(27.2% identity in 349 aa overlap); Z99117|BSUB0014_221 from Bacillus subtilis (353 aa), FASTA scores: opt: 394,E(): 8.6e-19, (28.7% identity in 324 aa overlap). Q7U2K6 No cell wall and cell processes Rv0205 NC_002945.3 Mycobrowser_v2 CDS 244680 247514 . - 0 Mb0212c mmpL3 POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL3 Mb0212c, mmpL3, len: 944 aa. Equivalent to Rv0206c,len: 944 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 944 aa overlap). Possible mmpL3,conserved transmembrane transport protein (see first citation below), equivalent to Z95398|MLCL622.18c from Mycobacterium leprae (955 aa), FASTA scores: opt: 806,E(): 1.8e-21, (57.2% identity in 243 aa overlap). Member of RND superfamily, similar to others. BELONGS TO THE MMPL FAMILY. TBparse score is 0.928. Q7U2K5 No NC_002945.3 Mycobrowser_v2 CDS 247580 248308 . - 0 Mb0213c CONSERVED HYPOTHETICAL PROTEIN Mb0213c, -, len: 242 aa. Equivalent to Rv0207c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). Q7U2K4 No conserved hypotheticals Rv0207c NC_002945.3 Mycobrowser_v2 CDS 248311 249102 . - 0 Mb0214c HYPOTHETICAL METHLYTRANSFERASE (METHYLASE) Mb0214c, -, len: 263 aa. Equivalent to Rv0208c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 263 aa overlap). Hypothetical methyltransferase (EC 2.1.1.-), equivalent to Z95398|MLCL622_20 from Mycobacterium leprae (279 aa),FASTA score: (64.2% identity in 246 aa overlaps). Also similar to others e.g. 10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c HYPOTHETICAL METHLYTRANSFERASE from Streptomyces coelicolor (271 aa). Could start at aa 7. X2BE98,P67499 No intermediary metabolism and respiration Rv0208c NC_002945.3 Mycobrowser_v2 CDS 251978 253798 . + 0 Mb0217 pckA probable iron-regulated phosphoenolpyruvate carboxykinase [gtp] pcka (phosphoenolpyruvate carboxylase) (pepck)(pep carboxykinase) Mb0217, pckA, len: 606 aa. Equivalent to Rv0211,len: 606 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 606 aa overlap). Probable pckA (alternate gene names: pckG and pck1), phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32), equivalent to Z95398|MLCL622_21 PROBABLE PHOSPHOENOLPYRUVATE CARBOXYKINASE from Mycobacterium leprae (609 aa), FASTA score: (86.1% identity in 605 aa overlap). Also highly similar to others e.g. PPCK_NEOFR|P22130 phosphoenolpyruvate carboxykinase [GTP] (608 aa), FASTA scores: opt: 2287, E(): 0, (55.9% identity in 598 aa overlap). Contains PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. BELONGS TO THE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] FAMILY. X2BEE3,P65687 No intermediary metabolism and respiration Rv0211 NC_002945.3 Mycobrowser_v2 CDS 623271 623432 . - 0 Mb0543A Conserved protein Mb0543A, len: 53 aa. Equivalent to Rv0530A len: 53 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 53 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BFB5 No conserved hypotheticals Rv0530A NC_002945.3 Mycobrowser_v2 CDS 253865 254836 . - 0 Mb0218c nadR POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN NADR (PROBABLY ASNC-FAMILY) Mb0218c, nadR, len: 323 aa. Equivalent to Rv0212c,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Possible nadR (alternate gene name: nadI), transcriptional regulator,similar to others e.g. NADR_ECOLI|P27278 transcriptional regulator from Escherichia coli (410 aa), FASTA scores: opt: 377, E (): 1e-17, (31.1% identity in 347 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2K1 No NC_002945.3 Mycobrowser_v2 CDS 384632 385516 . + 0 Mb0323 POSSIBLE BETA-1,3-GLUCANASE PRECURSOR Mb0323, -, len: 294 aa. Equivalent to Rv0315, len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 294 aa overlap). Possible beta-1,3-glucanase precursor (EC 3.2.1.-) (has hydrophobic stretch in its N-terminal part), similar to others e.g. Q51333|AAC44371.1 BETA-1,3-GLUCANASE II A from Oerskovia xanthineolytica (306 aa), FASTA scores: opt: 76, E(): 3e-14, (34.1% identity in 302 aa overlap); and AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia xanthineolytica (435 aa). Contains glycosyl hydrolases family 16 active site signature (PS01034). Q7U2A2 No intermediary metabolism and respiration Rv0315 NC_002945.3 Mycobrowser_v2 CDS 254833 256146 . - 0 Mb0219c POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb0219c, -, len: 437 aa. Equivalent to Rv0213c,len: 437 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 437 aa overlap). Possible methyltransferase (EC 2.1.1.-), weakly similar to others methyltransferases e.g. AF127374_30|LINA from Streptomyces lavendulae (611 aa), FASTA scores: opt: 400, E(): 8.1e-19,(27.3% identity in 388 aa overlap); Q50258 fortimicin kl1 methyltransferase (553 aa), FASTA scores: opt: 267, E(): 1.2e-13, (29.3% identity in 351 aa overlap). Q7U2K0 No intermediary metabolism and respiration Rv0213c NC_002945.3 Mycobrowser_v2 CDS 263037 264248 . + 0 Mb0226 lipC PROBABLE ESTERASE LIPC Mb0226, lipC, len: 403 aa. Equivalent to Rv0220,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 403 aa overlap). Probable esterase (EC 3.1.1.-), similar to others proteins and esterases from various organisms and Mycobacterium tuberculosis e.g. Q50681 (431 aa), FASTA scores: opt: 841, E(): 0, (38.2% identity in 408 aa overlap); Rv1426c, Rv1399c, etc. Contains PS00122 Carboxylesterases type-B serine active site. Q7U2J3 No intermediary metabolism and respiration Rv0220 NC_002945.3 Mycobrowser_v2 CDS 285510 286676 . + 0 Mb0243 lpqI PROBABLE CONSERVED LIPOPROTEIN LPQI Mb0243, lpqI, len: 388 aa. Equivalent to Rv0237,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 388 aa overlap). Probable lpQI,conserved lipoprotein, equivalent to AL022486|MLCB1883_8|T44873 probable secreted hydrolase from Mycobacterium leprae (387 aa), FASTA scores: opt: 1831, E(): 0, (73.3% identity in 390 aa overlap). Also similar to other lipoproteins and various hydrolases e.g. P40406|2126897|YBBD_BACSU|I39839 HYPOTHETICAL 70.6 KDA LIPOPROTEIN from Bacillus subtilis (642 aa); P48823|HEXA_ALTSO BETA-HEXOSAMINIDASE A PRECURSOR from ALTEROMONAS SP. (598 aa), FASTA scores: opt: 415, E(): 5.8e-17, (31.2% identity in 343 aa overlap); PCC6803|P74340 BETA-GLUCOSIDASE from Synechocystis sp. (538 aa), FASTA scores: opt: 414, E(): 6.1e-17, (30.6 identity in 320 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U2H7 No cell wall and cell processes Rv0237 NC_002945.3 Mycobrowser_v2 CDS 256260 257873 . + 0 Mb0220 fadD4 PROBABLE FATTY-ACID-COA LIGASE FADD4 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0220, fadD4, len: 537 aa. Equivalent to Rv0214,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 537 aa overlap). Probable fadD4,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. 4CL_PINTA|P41636 4-coumarate--coa ligase (EC 6.2.1.12) (537 aa), FASTA scores: opt: 622, E(): 1e-31,(30.0% identity in 514 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY6A4.14 FASTA score: (30.7% identity in 501 aa overlap); MTCY493_27,MTCY07A7_11, MTCI28_6. Contains PS00455 putative AMP-binding domain signature. Q7U2J9 No NC_002945.3 Mycobrowser_v2 CDS 257915 259081 . - 0 Mb0221c fadE3 PROBABLE ACYL-COA DEHYDROGENASE FADE3 Mb0221c, fadE3, len: 388 aa. Equivalent to Rv0215c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Probable fadE3,acyl-dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis (EC 1.3.99.-) (379 aa), FASTA scores: opt: 812, E(): 0,(39.5% identity in 354 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Q7U2J8 No NC_002945.3 Mycobrowser_v2 CDS 259138 260151 . + 0 Mb0222 double hotdog hydratase Mb0222, -, len: 337 aa. Equivalent to Rv0216, len: 337 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 337 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622_22 from Mycobacterium leprae (339 aa), FASTA scores: E(): 0, (73.7 identity in 338 aa overlap). Q7U2J7 No intermediary metabolism and respiration Rv0216 NC_002945.3 Mycobrowser_v2 CDS 260148 261056 . - 0 Mb0223c lipW POSSIBLE ESTERASE LIPW Mb0223c, lipW, len: 302 aa. Equivalent to Rv0217c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Possible esterase (EC 3.1.1.-), showing similarity with others e.g. EST_ACICA|P18773 esterase (303 aa), FASTA scores: opt: 320, E(): 3.2e-13, (29.2% identity in 274 aa overlap). Q7U2J6 No NC_002945.3 Mycobrowser_v2 CDS 261149 262477 . + 0 Mb0224 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0224, -, len: 442 aa. Equivalent to Rv0218, len: 442 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 442 aa overlap). Probable conserved transmembrane protein, some similarity with sulfite oxidases (EC 1.8.3.1) e.g. SUOX_HUMAN|P51687 sulfite oxidase precursor (488 aa), FASTA scores: opt: 153, E(): 0.0087, (28.6% identity in 161 aa overlap); and with some nitrate reductases (EC 1.6.6.3) e.g. NIA_FUSOX|P39863 nitrate reductase (NADPH) (905 aa), FASTA scores: opt: 143, E(): 0.06, (29.3% identity in 92 aa overlap). Also similar to BSUB0017_86 from Mycobacterium tuberculosis. Q7U2J5 No cell wall and cell processes Rv0218 NC_002945.3 Mycobrowser_v2 CDS 264292 265065 . + 0 Mb0227 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb0227, -, len: 257 aa. Equivalent to 5' end of Rv0221, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 234 aa overlap). Conserved hypothetical protein, similar to others proteins from Mycobacterium tuberculosis e.g. Q50680|Rv2285|MT2343|MTCY339.25c hypothetical 47.7 kDa protein (445 aa), FASTA scores: opt: 455, E(): 8.1e-23,(26.7% identity in 461 aa overlap); Rv3740c, Rv3734c, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein,echA1 (Rv0222). Q7U2J2 No NC_002945.3 Mycobrowser_v2 CDS 264931 266088 . - 0 Mb0228c PROBABLE ALDEHYDE DEHYDROGENASE Mb0228c, -, len: 385 aa. Equivalent to Rv0223c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(95.3% identity in 364 aa overlap). Probable aldehyde dehydrogenase (EC 1.2.1.-), similar to others e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde dehydrogenase from Deinococcus radiodurans strain R1 (495 aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent from Gluconobacter oxydans (498 aa), FASTA scores: opt: 1157, E (): 0, (42.1% identity in 482 aa overlap); etc. Also similar to Rv0768, Rv2858c, etc from Mycobacterium tuberculosis. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site; and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to a shorter product,with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 487 aa). Q7U2J1 No intermediary metabolism and respiration Rv0223c NC_002945.3 Mycobrowser_v2 CDS 266187 266951 . - 0 Mb0229c POSSIBLE METHYLTRANSFERASE (METHYLASE) Mb0229c, -, len: 254 aa. Equivalent to Rv0224c,len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 254 aa overlap). Possible methyltransferase (EC 2.1.1.-), showing weak similarity with other methyltransferases e.g. P74388 STEROL-C-METHYLTRANSFERASE (318 aa), FASTA scores: opt: 190, E(): 3.6e-05, (33.3% identity in 114 aa overlap). Equivalent to AL022486|MLCB1883_1 from Mycobacterium leprae (269 aa), FASTA scores: opt: 1456, E(): 0, (82.9% identity in 252 aa overlap). Also some similarity with MTCY21B4.22c from Mycobacterium tuberculosis FASTA score: (30.1% identity in 136 aa overlap). X2BEA5,Q7U2J0 No intermediary metabolism and respiration Rv0224c NC_002945.3 Mycobrowser_v2 CDS 266987 268141 . + 0 Mb0230 POSSIBLE CONSERVED PROTEIN Mb0230, -, len: 384 aa. Equivalent to Rv0225, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 384 aa overlap). Possible conserved protein involved in LPS biosynthesis, similar to O26275 LPS BIOSYNTHESIS RFBU RELATED PROTEIN (382 aa), FASTA scores: opt: 426, E(): 1.2e-20, (28.2% identity in 394 aa overlap). Some similarity with Rv3032 from Mycobacterium tuberculosis FASTA score: (31.6% identity in 228 aa overlap). Q7U2I9 No cell wall and cell processes Rv0225 NC_002945.3 Mycobrowser_v2 CDS 321089 321598 . - 0 Mb0274c HYPOTHETICAL PROTEIN Mb0274c, -, len: 169 aa. Equivalent to Rv0268c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Hypothetical unknown protein. Q7U2E8 No conserved hypotheticals Rv0268c NC_002945.3 Mycobrowser_v2 CDS 268158 269888 . - 0 Mb0231c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0231c, -, len: 576 aa. Equivalent to Rv0226c,len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 576 aa overlap). Probable conserved transmembrane protein, equivalent, except in N-terminal part, to AC32114.1|AL583926 conserved membrane protein from Mycobacterium leprae (600 aa), FASTA scores: opt: 2086, E(): 0, (70.3% identity in 579 aa overlap). Also similar to AL021411|SC7H1_20 from Streptomyces coelicolor (483 aa), FASTA scores: opt: 180, E(): 0.00028, (26.5 identity in 388 aa overlap). Q7U2I8 No cell wall and cell processes Rv0226c NC_002945.3 Mycobrowser_v2 CDS 269898 271163 . - 0 Mb0232c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0232c, -, len: 421 aa. Equivalent to Rv0227c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 421 aa overlap). Possible conserved membrane protein, equivalent to AL022486|MLCB1883_4 from Mycobacterium leprae (448 aa), FASTA scores: opt: 2148,E(): 0, (76.6% identity in 423 aa overlap). Q7U2I7 No cell wall and cell processes Rv0227c NC_002945.3 Mycobrowser_v2 CDS 286752 287366 . + 0 Mb0244 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb0244, -, len: 204 aa. Equivalent to Rv0238, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible transcriptional regulatory protein, TetR family,equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative tetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266, E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa). Q7U2H6 No regulatory proteins Rv0238 NC_002945.3 Mycobrowser_v2 CDS 271379 272602 . + 0 Mb0233 PROBABLE INTEGRAL MEMBRANE ACYLTRANSFERASE Mb0233, -, len: 407 aa. Equivalent to Rv0228, len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Probable integral membrane acyltransferase (EC 2.3.1.-), equivalent to 3063875|CAA18555.1|AL022486|T44870 ACYLTRANSFERASE from Mycobacterium leprae (384 aa), FASTA scores: opt: 2004,E(): 0, (79.3% identity in 381 aa overlap). Also similar to others e.g. Q11064 PROBABLE ACYLTRANSFERASE CY50.28C (383 aa), FASTA scores: opt: 372, E(): 2.6e-16, (35.9% identity in 359 aa overlap); Q00718|MDMB_STRMY ACYLTRANSFERASE. Very similar to Rv0111, Rv1254, etc from Mycobacterium tuberculosis. Q7U2I6 No intermediary metabolism and respiration Rv0228 NC_002945.3 Mycobrowser_v2 CDS 287428 287661 . + 0 Mb0245 vapb24 possible antitoxin vapb24 Mb0245, -, len: 77 aa. Equivalent to Rv0239, len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Conserved hypothetical protein, weakly similar to Rv1839c|Z83859|MTCY359_34 from Mycobacterium tuberculosis (87 aa), FASTA scores: opt: 88,E(): 5, (40.0% identity in 45 aa overlap). Q7U2H5 No virulence, detoxification, adaptation Rv0239 NC_002945.3 Mycobrowser_v2 CDS 272630 273310 . - 0 Mb0234c possible conserved membrane protein with pin domain Mb0234c, -, len: 226 aa. Equivalent to Rv0229c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Possible conserved membrane protein, similar to several proteins from Mycobacterium tuberculosis. Other possible start sites and could be shorter as C-terminal region has some similarity with Rv2757c|D70880 from Mycobacterium tuberculosis (138 aa), FASTA scores: E(): 1e-15, (45.3% identity in 137 aa overlap), and Rv0301, Rv2546, etc. Also some similarity with Q48177 virulence associated protein C (132 aa), FASTA scores: opt: 101, E(): 0.6, (24.3% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7U2I5 No cell wall and cell processes Rv0229c NC_002945.3 Mycobrowser_v2 CDS 273307 274287 . - 0 Mb0235c php PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE) (ARYLDIALKYLPHOSPHATASE) (PARAOXONASE) (A-ESTERASE) (ARYLTRIPHOSPHATASE) (PARAOXON HYDROLASE) Mb0235c, php, len: 326 aa. Equivalent to Rv0230c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 326 aa overlap). Probable php,phosphotriesterase (EC 3.1.8.1), similar to others e.g. AAK42653.1|AE006849 putative aryldialkylphosphatase (phosphotriesterase) (paraoxonase) from Sulfolobus solfataricus (314 aa); PHP_ECOLI|P45548 PHOSPHOTRIESTERASE HOMOLOGY PROTEIN from Escherichia coli (292 aa), FASTA scores: opt: 408, E(): 7.1e-20, (31.1% identity in 305 aa overlap ); OPD_FLASP|P16648 parathion hydrolase precursor (365 aa), FASTA scores: opt: 319, E(): 5.1e-14, (34.5% identity in 333 aa overlap); etc. BELONGS TO THE PHOSPHOTRIESTERASE FAMILY. COFACTOR: CONTAINS 2 MOLES OF ZINC PER SUBUNIT. Q7U2I4 No NC_002945.3 Mycobrowser_v2 CDS 274382 276088 . + 0 Mb0236 fadE4 PROBABLE ACYL-COA DEHYDROGENASE FADE4 Mb0236, fadE4, len: 568 aa. Equivalent to Rv0231,len: 568 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 568 aa overlap). Probable fadE4,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. O29752 ACYL-COA DEHYDROGENASE (ACD-3) from Archaeoglobus fulgidus (576 aa), FASTA scores: opt: 1788, E(): 0, (51.0% identity in 577 aa overlap); ACDB_BACSU|P45857 acyl-coa dehydrogenase from Bacillus subtilis (379 aa), FASTA scores: opt: 232, E(): 2.2e- 08, (21.6% identity in 291 aa overlap). Q7U2I3 No NC_002945.3 Mycobrowser_v2 CDS 380202 381431 . + 0 Mb0319 unknown protein Mb0319, -, len: 409 aa. Equivalent to Rv0311, len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Hypothetical unknown protein. Contains PS00881 Protein splicing signature. Q7U2A6 No conserved hypotheticals Rv0311 NC_002945.3 Mycobrowser_v2 CDS 276223 276912 . + 0 Mb0237 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY) Mb0237, -, len: 229 aa. Equivalent to Rv0232, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Probable transcriptional regulatory protein, tetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149, E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, tetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U2I2 No regulatory proteins Rv0232 NC_002945.3 Mycobrowser_v2 CDS 276909 277853 . + 0 Mb0238 nrdB ribonucleoside-diphosphate reductase (beta chain) nrdb (ribonucleotide reductase small chain) Mb0238, nrdB, len: 314 aa. Equivalent to Rv0233,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 314 aa overlap). Probable nrdB (alternate gene name: rnrS) ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1), similar to others e.g. RIR2_SCHPO|P36603 ribonucleoside-diphosphate reductase (391 aa), FASTA scores: opt: 168, E(): 0.00018,(26.1% identity in 199 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. COFACTOR: BINDS 2 IRON IONS. X2BEH1,Q7U2I1 No information pathways Rv0233 NC_002945.3 Mycobrowser_v2 CDS 277929 279464 . - 0 Mb0239c gabD1 succinate-semialdehyde dehydrogenase [nadp+] dependent (ssdh) gabd1 Mb0239c, gabD1, len: 511 aa. Equivalent to Rv0234c,len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable gabD1,succinate-semialdehyde dehydrogenase [NADP+] dependent (EC 1.2.1.16), equivalent to AL022486|MLCB1883_6 PROBABLE ALDEHYDE DEHYDROGENASE from Mycobacterium leprae (457 aa),FASTA scores: opt: 2617, E(): 0, (85.7% identity in 455 aa overlap). Also highly similar to Q55585|GABD|SLR0370 PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE from Synechocystis sp. strain PCC 6803 (454 aa), FASTA scores: opt: 1676, E(): 0, (55.8% identity in 455 aa overlap); and similar to others e.g. GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from Escherichia coli (482 aa), FASTA scores: opt: 929, E(): 0, (36.5% identity in 452 aa overlap); etc. Note that similar to other cytosolic aldehyde dehydrogenases with EC number: 1.2.1.3. Also similar to Rv0768|aldA semialdehyde dehydrogenase from Mycobacterium tuberculosis (489 aa); and gabD2|Rv1731|MTCY04C12.16 POSSIBLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDANT from Mycobacterium tuberculosis (518 aa). Contains PS00070 aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Could start at different site by homology. Note that previously known as gabD2. X2BEB3,Q7U2I0 No NC_002945.3 Mycobrowser_v2 CDS 279490 280938 . - 0 Mb0240c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0240c, -, len: 482 aa. Equivalent to Rv0235c,len: 482 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 482 aa overlap). Possible conserved transmembrane protein, highly similar to AL133278|CAB61913.1|SCM11_2 putative integral membrane protein from Streptomyces coelicolor (470 aa), FASTA scores: opt: 2116, E(): 0, (61.8% identity in 474 aa overlap); and similar to hypothetical proteins from other organisms e.g. Q13392|384D8_7 hypothetical protein (579 aa), FASTA scores: opt: 355, E(): 6.9e-17, (28.5% identity in 569 aa overlap). Q7U2H9 No cell wall and cell processes Rv0235c NC_002945.3 Mycobrowser_v2 CDS 280973 285175 . - 0 Mb0241c aftd possible arabinofuranosyltransferase aftd Mb0241c, -, len: 1400 aa. Equivalent to Rv0236c,len: 1400 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1400 aa overlap). Probable conserved transmembrane protein, equivalent to AL022486|CAC32102.1|MLCB1883_7 possible integral membrane protein from Mycobacterium leprae (1440 aa), FASTA scores: opt: 7491, E(): 0, (78.8% identity in 1397 aa overlap). Q7U2H8 No cell wall and cell processes Rv0236c NC_002945.3 Mycobrowser_v2 CDS 285222 285395 . - 0 Mb0242c SMALL SECRETED PROTEIN Mb0242c, -, len: 57 aa. Equivalent to Rv0236A, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Small secreted protein. X2BEG4 No cell wall and cell processes Rv0236A NC_002945.3 Mycobrowser_v2 CDS 704489 704734 . + 0 Mb0624 vapb28 possible antitoxin vapb28 Mb0624, -, len: 81 aa. Equivalent to Rv0608, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical short proteins e.g. Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores: opt: 159, E(): 1.2e-09, (43.0% identity in 86 aa overlap); Rv2760c (89 aa); Rv1740 (70 aa), etc. Q7U1M8 No virulence, detoxification, adaptation Rv0608 NC_002945.3 Mycobrowser_v2 CDS 288136 288978 . - 0 Mb0247c htdx probable 3-hydroxyacyl-thioester dehydratase htdx Mb0247c, -, len: 280 aa. Equivalent to Rv0241c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical protein from Mycobacterium leprae (280 aa), FASTA scores: opt: 1564, E(): 0, (81.8% identity in 280 aa overlap); and CAC32097.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (300 aa). Also similar to proteins from other organisms e.g. CAB77291.1|AL160312 putative dehydratase from Streptomyces coelicolor (291 aa); part of BAA92930.1|AB032743 fatty acid synthetase beta subunit from Pichia angusta (2060 aa). Q7U2H3 No intermediary metabolism and respiration Rv0241c NC_002945.3 Mycobrowser_v2 CDS 288989 290353 . - 0 Mb0248c fabG4 PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG4 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) Mb0248c, fabG4, len: 454 aa. Equivalent to Rv0242c,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 454 aa overlap). Probable fabG4,3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100),equivalent to 3063883|CAA18568.1|AL022486|MLCB1883_13|T44878 3-oxoacyl-[acyl-carrier protein] reductase homolog from Mycobacterium leprae (454 aa), FASTA scores: opt: 2486,E(): 0, (84.8% identity in 454 aa overlap). C-terminal part highly similar to many FabG proteins e.g. U39441|VHU3944 1_2 from Vibrio harveyi (244 aa), FASTA scores: opt: 562, E(): 3.4e-28, (40.2% identity in 241 aa overlap); U91631|PAU91631_3 from Pseudomonas aeruginosa (247 aa), FASTA scores: opt: 584, E(): 1.5e-29, (44.4% identity in 241 aa overlap). Has N-terminal extension of ~200 aa and C-terminal part contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U2H2 No NC_002945.3 Mycobrowser_v2 CDS 328747 329328 . + 0 Mb0280 conserved protein Mb0280, -, len: 193 aa. Equivalent to Rv0274, len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 193 aa overlap). Conserved hypothetical protein, highly similar to AAK25058.1|AE005973 conserved hypothetical protein from Caulobacter crescentus (174 aa). Shows also some similarity to others hypothetical proteins e.g. AJ002571|BSAJ2571_7 from Bacillus subtilis (316 aa), FASTA scores: opt: 138, E(): 0.033, (27.1% identity in 133 aa overlap). Previous hits with Q56415|M85195 FOSFOMYCIN-RESISTANCE PROTEIN from SERRATIA MARCESCENS (141 aa), FASTA scores: opt: 82, E(): 1.1e -08, (29.1% identity in 151 aa overlap). Contains PS00082 Extradiol ring-cleavage dioxygenases signature near C-terminus. TBparse score is 0.914. Q7U2E2 No conserved hypotheticals Rv0274 NC_002945.3 Mycobrowser_v2 CDS 290495 291817 . + 0 Mb0249 fadA2 PROBABLE ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE) Mb0249, fadA2, len: 440 aa. Equivalent to Rv0243,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable fadA2,acetyl-CoA acyltransferase (3-acyl-CoA thiolase) (EC 2.3.1.16), equivalent, but shorter 17 aa, to AL022486|MLCB1883_14T44879 acetyltransferase from Mycobacterium leprae (457 aa), FASTA scores: opt: 250 7,E(): 0, (87.6% identity in 435 aa overlap). Also highly similar to many e.g. G83046|PA478 probable acyl-CoA thiolase from Pseudomonas aeruginosa (425 aa); AB77293.1|AL160312 putative ketoacyl CoA thiolase from Streptomyces coelicolor (428 aa); P76503|7449731|YFCY_ECOLI|D65007|B2342 PROBABLE 3-KETOACYL-COA THIOLASE (ACETYL-COA ACYLTRANSFERASE) (BETA-KETOTHIOLASE) from Escherichia coli strain K-12 (436 aa), FASTA scores: opt: 914, E(): 0, (38.2% identity in 434 aa overlap); P55084|ECHB_HUMAN MITOCHONDRIAL TRIFUNCTONAL ENZYME (474 aa), FASTA scores: opt: 881, E(): 0, (37.7 identity in 451 aa overlap). Contains PS00099 Thiolases active site. BELONGS TO THE THIOLASE FAMILY. Q7U2H1 No NC_002945.3 Mycobrowser_v2 CDS 292123 293958 . - 0 Mb0250c fadE5 PROBABLE ACYL-COA DEHYDROGENASE FADE5 Mb0250c, fadE5, len: 611 aa. Equivalent to Rv0244c,len: 611 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 611 aa overlap). Probable fadE5,acyl-CoA dehydrogenase (EC 1.3.99.-), equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa),FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa overlap). Also highly similar to AL0211|MTV007.14 from Mycobacterium tuberculosis (609 aa), FASTA scores: opt: 2576, E(): 0, (64.6% identity in 611 aa overlap); and to various other bacterial proteins described as putative acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229,E(): 6.8e-08, (29.8% identity in 409 aa overlap); etc. Q7U2H0 No NC_002945.3 Mycobrowser_v2 CDS 385565 386179 . + 0 Mb0324 POSSIBLE MUCONOLACTONE ISOMERASE Mb0324, -, len: 204 aa. Equivalent to Rv0316, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible muconolactone isomerase (EC 5.3.3.-), showing weak similarity with some muconolactone isomerases e.g. O33947|CTC1_ACILW MUCONOLACTONE DELTA-ISOMERASE 1 (MIASE 1)(96 aa), FASTA scores: opt: 179, E(): 3.9e-05, (32.6% identity in 92 aa overlap). Q7U2A1 No intermediary metabolism and respiration Rv0316 NC_002945.3 Mycobrowser_v2 CDS 294330 294818 . + 0 Mb0251 possible oxidoreductase Mb0251, -, len: 162 aa. Equivalent to Rv0245, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to AL022486|MLCB1883_17|T44882 probable oxidoreductase from Mycobacterium leprae (162 aa), FASTA scores: opt: 860,E(): 0, (83.4% identity in 157 aa overlap). Also similar to several hypothetical proteins and various oxidoreductases e.g. AAK24246.1|AE005898 NADH:riboflavin 5'-phosphate oxidoreductase from Caulobacter crescentus (174 aa); Q02058|DIM6_STRCO|CAA45048.1 ACTINORHODIN POLYKETIDE DIMERASE from STREPTOMYCES COELICOLOR (177 aa),FASTA scores: opt: 308, E(): 3. 2e-15, (37.8% identity in 143 aa overlap). Also similar to Z84498|Rv1939|MTCY09F9.25c from Mycobacterium tuberculosis (171 aa), FASTA scores: opt: 517, E(): 3.5e-30, (49.4% identity in 158 aa overlap). Q7U2G9 No intermediary metabolism and respiration Rv0245 NC_002945.3 Mycobrowser_v2 CDS 295134 296444 . + 0 Mb0252 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0252, -, len: 436 aa. Equivalent to Rv0246, len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 436 aa overlap). Probable conserved integral membrane protein, similar to Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 712, E(): 0, (33.2% identity in 422 aa overlap). Q7U2G8 No cell wall and cell processes Rv0246 NC_002945.3 Mycobrowser_v2 CDS 296441 297187 . - 0 Mb0253c PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE) Mb0253c, -, len: 248 aa. Equivalent to Rv0247c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Probable succinate dehydrogenase, iron-sulfur subunit (EC 1.3.99.1), highly similar to CAC44313.1|AL596043 putative succinate dehydrogenase iron-sulfur subunit from Streptomyces coelicolor (259 aa); and similar to iron-sulphur protein subunits of fumarate reductase or succinate dehydrogenases from many bacteria e.g. NP_147618.1|7521083|B72691 fumarate reductase iron-sulfur protein from Aeropyrum pernix (305 aa); NP_069516.1|2649932|AAB90556.1|AE001057 succinate dehydrogenase iron-sulfur subunit B (sdhB) from Archaeoglobus fulgidus (236 aa); etc. Also similar to Q10761|FRDB_MYCTU|7431693|F70762 FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 358, E():1e-16, (31.3% identity in 214 aa overlap). Contains PS00197 2Fe-2S ferredoxins,iron-sulfur binding region signature. NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?). Q7U2G7 No intermediary metabolism and respiration Rv0247c NC_002945.3 Mycobrowser_v2 CDS 329258 329983 . - 0 Mb0281c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0281c, -, len: 241 aa. Equivalent to Rv0275c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 241 aa overlap). Putative transcriptional regulator, showing some similarity with Rv0825c from Mycobacterium tuberculosis (213 aa), FASTA scores: opt: 230, E(): 2.7e-07, (32.6% identity in 190 aa overlap). Belongs to Mycobacterium tuberculosis regulatory protein family with many TetR orthologues. Q7U2E1 No regulatory proteins Rv0275c NC_002945.3 Mycobrowser_v2 CDS 297188 299128 . - 0 Mb0254c PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE) Mb0254c, -, len: 646 aa. Equivalent to Rv0248c,len: 646 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 646 aa overlap). Probable succinate dehydrogenase, flavoprotein subunit (EC 1.3.99.1), highly similar to flavoprotein subunit of various succinate dehydrogenases e.g. M88696|RIRSDHA_1 flavoprotein from Rickettsia prowazekii (596 aa), FASTA scores: opt: 651,E(): 0, (34.6 % identity in 598 aa overlap). Also similar to truncated U00022_17 flavoprotein from Mycobacterium leprae (401 aa), FASTA scores: opt: 677, E(): 0, (39.0% identity in 423 aa overlap). NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?). Q7U2G6 No intermediary metabolism and respiration Rv0248c NC_002945.3 Mycobrowser_v2 CDS 299159 299980 . - 0 Mb0255c probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) Mb0255c, -, len: 273 aa. Equivalent to Rv0249c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Probable succinate dehydrogenase, membrane-anchor subunit for succinate dehydrogenase encoded by Rv0247c and Rv0248c. Highly similar to AC44315.1|AL596043 putative integral membrane protein from Streptomyces coelicolor (278 aa). NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?). Q7U2G5 No intermediary metabolism and respiration Rv0249c NC_002945.3 Mycobrowser_v2 CDS 300498 300977 . - 0 Mb0257c hsp HEAT SHOCK PROTEIN HSP (HEAT-STRESS-INDUCED RIBOSOME-BINDING PROTEIN A) Mb0257c, hsp, len: 159 aa. Equivalent to Rv0251c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). hsp (alternate gene name: hsp20, hrpA, acr2), heat-stress-induced ribosome-binding protein A (see citations below). Highly similar to AAD39038.1|AF072875_1|AF072875 putative HSP20 from Mycobacterium smegmatis (145 aa), FASTA scores: opt: 479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and similar to many bacterial and eukaryotic hsp proteins e.g. P12811|HS2C_CHLRE CHLOROPLAST HEAT SHOCK 22KD PROTEIN from CHLAMYDOMONAS REINHARDTII (157 aa), FASTA scores: opt: 184, E(): 1.2e-05, (32.4% identity in 142 aa overlap). Also similar to PCC6803 Spore protein sp21 from Synechocystis sp. (146 aa), FASTA scores: opt: 213, E(): 1.2e-07, (30.3 identity in 145 aa overlap). Also similar to P30223|14KD_MYCTU 14 KDA ANTIGEN (16 KDA ANTIGEN) 19K major membrane protein (HSP 16.3) from Mycobacterium tuberculosis (144 aa). BELONG TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY. Q7U2G3 No NC_002945.3 Mycobrowser_v2 CDS 328030 328650 . - 0 Mb0279c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0279c, -, len: 206 aa. Equivalent to Rv0273c,len: 206 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 206 aa overlap). Possible transcriptional regulator, showing some similarity to hypothetical regulators from Mycobacterium tuberculosis e.g. P96222|Rv3855|MTCY01A6.13c (216 aa); O08377|Rv1534|MTCY07A7A.03 (225 aa), FASTA scores: opt: 123, E(): 3.2e-06, (28.5% identity in 172 aa overlap). Q7U2E3 No regulatory proteins Rv0273c NC_002945.3 Mycobrowser_v2 CDS 314108 314740 . - 0 Mb0270c CONSERVED HYPOTHETICAL PROTEIN Mb0270c, -, len: 210 aa. Equivalent to Rv0264c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Conserved hypothetical protein, equivalent to CAC32080.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (222 aa). Also similar to others hypothetical proteins e.g. AL121596|SC51A_20 from Streptomyces coelicolor (252 aa), FASTA scores: opt: 420, E(): 2.7e-20, (41.7% identity in 204 aa overlap); P75744|YBGJ_ECOLI HYPOTHETICAL 23.9 KD PROTEIN from Escherichia coli (218 aa), FASTA scores: E(): 2.1e-14, (35.7% identity in 182 aa overlap); YH31_HAEIN|P44299|hi173 hypothetical protein from Haemophilus influenzae (213 aa), FASTA scores: opt: 252,E(): 8.3e-10, (31.1% identity in 183 aa overlap). Q7U2F2 No conserved hypotheticals Rv0264c NC_002945.3 Mycobrowser_v2 CDS 301191 303752 . + 0 Mb0258 nirB PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB Mb0258, nirB, len: 853 aa. Equivalent to Rv0252,len: 853 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 853 aa overlap). Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4), flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0,(49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA scores: opt: 2902, E(): 0, (54.2% identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. HOMODIMER WHICH ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron; Siroheme. Q7U2G2 No intermediary metabolism and respiration Rv0252 NC_002945.3 Mycobrowser_v2 CDS 303778 304134 . + 0 Mb0259 nirD PROBABLE NITRITE REDUCTASE [NAD(P)H] SMALL SUBUNIT NIRD Mb0259, nirD, len: 118 aa. Equivalent to Rv0253,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Probable nirD,nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4),similar to others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia coli strains K12 and O157:H7 (108 aa), FASTA scores: opt: 271, E():1.7e-12, (41.9% identity in 105 aa overlap). ASSOCIATES WITH NIRB|Rv0252. Q7U2G1 No intermediary metabolism and respiration Rv0253 NC_002945.3 Mycobrowser_v2 CDS 304150 304674 . - 0 Mb0260c cobU probable bifunctional cobalamin biosynthesis protein cobu: cobinamide kinase + cobinamide phosphate guanylyltransferase Mb0260c, cobU, len: 174 aa. Equivalent to Rv0254c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Probable cobU,cobalamin biosynthesis protein including a cobinamide kinase (EC 2.-.-.-) and cobinamide phosphate guanylyltransferase (EC 2.-.-.-). Highly similar to many e.g. Q05599|COBU_SALTY COBINAMIDE KINASE / COBINAMIDE PHOSPHATE GUANYLYLTRANSFERASE from Salmonella typhimurium (181 aa), FASTA scores: opt: 308, E(): 1.1e-14, (38.7% identity in 181 aa overlap); P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional cobalamin biosynthesis protein cobU from Escherichia coli strains K12 and O157:H7 (181 aa); part of AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa),FASTA scores: opt: 445, E(): 3.6e-23, (46.0% identity in 176 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2G0 No NC_002945.3 Mycobrowser_v2 CDS 1886443 1887147 . + 0 Mb1703 unknown protein Mb1703, -, len: 234 aa. Equivalent to Rv1676, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 234 aa overlap). Hypothetical unknown protein. Q7TZT4 No conserved hypotheticals Rv1676 NC_002945.3 Mycobrowser_v2 CDS 304699 306183 . - 0 Mb0261c cobQ1 probable cobyric acid synthase cobq1 Mb0261c, cobQ1, len: 494 aa. Equivalent to Rv0255c,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 494 aa overlap). Probable cobQ1,cobyric acid synthase, similar to many e.g. Z46611|RCBLUGNS_8 COBYRIC ACID SYNTHASE from R.capsulatus (483 aa), FASTA scores: opt: 1239, E(): 0, (47.1% identity in 493 aa overlap); P29932|COBQ_PSEDE COBYRIC ACID SYNTHASE from Pseudomonas denitrificans (484 aa), FASTA scores: opt: 1168, E():0, (44.9% identity in 490 aa overlap); etc. BELONGS TO THE COBB/COBQ FAMILY, COBQ SUBFAMILY. Note that previously known as cobQ. X2BEI1,P0A533 No NC_002945.3 Mycobrowser_v2 CDS 306202 307872 . - 0 Mb0262c PPE2 ppe family protein ppe2 Mb0262c, PPE2, len: 556 aa. Equivalent to Rv0256c,len: 556 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 556 aa overlap). Member of the M. tuberculosis PPE family, similar to many e.g. Rv0280,Rv0286, etc. Equivalent to Z98756|MLCB2492.30 from Mycobacterium leprae (572 aa), FASTA scores: opt: 1837,E(): 0, (62.9% identity in 461 aa overlap). Q7U2F9 No NC_002945.3 Mycobrowser_v2 CDS 309839 310984 . - 0 Mb0266c possible transcriptional regulatory protein Mb0266c, -, len: 381 aa. Equivalent to Rv0260c,len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 381 aa overlap). Possible two-component response regulator, highly similar to CAB72204.1|AL138851 putative transcriptional regulator from Streptomyces coelicolor (395 aa); and similar to O34394|D69851|YJJA conserved hypothetical protein from Bacillus subtilis (270 aa), FASTA scores: opt: 312, E(): 7.4e-14, (25.8% identity in 267 aa overlap). Also some similarity to regulatory proteins at C-terminal region e.g. CUTR_STRLI|Q03756 transcriptional regulatory protein (217 aa), FASTA scores: opt: 138, E(): 0.02, (30.6% identity in 111 aa overlap). Q7U2F5 No regulatory proteins Rv0260c NC_002945.3 Mycobrowser_v2 CDS 886262 886990 . - 0 Mb0814c HYPOTHETICAL PROTEIN Mb0814c, -, len: 242 aa. Equivalent to Rv0790c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Hypothetical unknown protein. Q7U197 No conserved hypotheticals Rv0790c NC_002945.3 Mycobrowser_v2 CDS 311084 312493 . - 0 Mb0267c narK3 PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION PROTEIN NARK3 (NITRITE FACILITATOR) Mb0267c, narK3, len: 469 aa. Equivalent to Rv0261c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable nirK3,nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),equivalent to AAB41700.1|U72744 nitrite extrusion protein from Mycobacterium fortuitum (471 aa); and 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein homolog from Mycobacterium leprae (517 aa; longer in N-terminus). Also similar to other nitrite extrusion proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 755, E(): 0, (35.0% identity in 466 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS. Q7U2F4 No NC_002945.3 Mycobrowser_v2 CDS 312634 313179 . - 0 Mb0268c aac AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE AAC (AAC(2')-IC) Mb0268c, aac, len: 181 aa. Equivalent to Rv0262c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). aac, aminoglycoside 2'-N-acetyltransferase (aac(2')-IC) (EC 2.3.1.-) (see citation below), highly similar to NP_302635.1|NC_002677 aminoglycoside 2'-N-acetyltransferase from Mycobacterium leprae (182 aa); Q49157|AAC2_MYCFO|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium fortuitum (195 aa), FASTA scores: opt: 884, E(): 0, (69.1% identity in 181 aa overlap); and P94968|AAC2_MYCSM|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium smegmatis (210 aa) (see also citation below). Also similar to Q52424|AAC2_PROST AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE from Providencia stuartii (178 aa). BELONGS TO THE AAC(2')-I FAMILY OF ACETYLTRANSFERASES. Note that previously known as aac(2')-IC. X2BEJ5,P0A5N1 No NC_002945.3 Mycobrowser_v2 CDS 313189 314091 . - 0 Mb0269c CONSERVED HYPOTHETICAL PROTEIN Mb0269c, -, len: 300 aa. Equivalent to Rv0263c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Conserved hypothetical protein, equivalent to NP_302634.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (305 aa). Also similar to others e.g. AL121596|SC51A_21 hypothetical protein from Streptomyces coelicolor (285 aa), FASTA scores: opt: 714, E(): 0, (45.3% identity in 289 aa overlap); NP_233164.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (309 aa); NP_406216.1|NC_003143 conserved hypothetical protein from Yersinia pestis (316 aa); YH30_HAEIN|P44298|hi1730 hypothetical protein from Haemophilus influenzae (309 aa),FASTA scores: opt: 430, E(): 3e-20, (29.6% identity in 284 aa overlap); etc. Also similar to carboxylases eg NP_415240.1|NC_000913|P75745|YBGK_ECOLI putative carboxylase from Escherichia coli strain K12 (310 aa),FASTA score: (34.6% identity in 286 aa overlap); NP_459698.1|NC_003197 putative carboxylase from Salmonella typhimurium (310 aa); and to middle part of NP_420636.1|NC_002696 urea amidolyase-related protein from Caulobacter crescentus (1207 aa). Q7U2F3 No conserved hypotheticals Rv0263c NC_002945.3 Mycobrowser_v2 CDS 314836 315828 . - 0 Mb0271c PROBABLE PERIPLASMIC IRON-TRANSPORT LIPOPROTEIN Mb0271c, -, len: 330 aa. Equivalent to Rv0265c,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Probable iron-transport lipoprotein, most similar to T36412|5763945|CAB53324.1|AL109974 probable iron-siderophore binding lipoprotein from Streptomyces coelicolor (350 aa); and (N-terminus may be incorrect) to T14166|3560508|AAC82551.1|AF027770 fxuD protein from Mycobacterium smegmatis (420 aa), FASTA scores: opt: 385,E(): 1.5e-16, (32.3% identity in 232 aa overlap). Also similar to AAB97475.1|U02617 DtxR/iron regulated lipoprotein precursor from Corynebacterium diphtheriae (355 aa); FECB_ECOLI|P15028 iron(III) dicitrate-binding periplasmic protein (300 aa), FASTA scores: opt: 191, E(): 2.3e-05, (26.5% identity in 196 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as fecB2. Q7U2F1 No cell wall and cell processes Rv0265c NC_002945.3 Mycobrowser_v2 CDS 315850 319479 . - 0 Mb0272c oplA PROBABLE 5-OXOPROLINASE OPLA (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) Mb0272c, oplA, len: 1209 aa. Equivalent to Rv0266c,len: 1209 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1209 aa overlap). Probable oplA, 5-oxoprolinase (EC 3.5.2.9), highly similar to others or to hypothetical proteins e.g. AAK24340.1|AE005906 hydantoinase/oxoprolinase from Caulobacter crescentus (1196 aa); NP_103129.1|14022305|BAB48915.1|AP002997 5-oxoprolinase from Mesorhizobium loti (1210 aa); CAC48426.1|AL603642 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (1205 aa); S77037|slr0697|1006579|BAA10729.1|D6400 HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC 6803 (1252 aa), FASTA scores: opt: 2016, E(): 0, (51.4% identity in 1247 aa overlap); P97608|OPLA_RAT|T42756|11278797 5-OXOPROLINASE (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) from Rattus norvegicus (1288 aa); etc. BELONGS TO THE OXOPROLINASE FAMILY. Q7U2F0 No NC_002945.3 Mycobrowser_v2 CDS 319656 321047 . + 0 Mb0273 narU probable integral membrane nitrite extrusion protein naru (nitrite facilitator) Mb0273, narU, len: 463 aa. Equivalent to Rv0267,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Probable narU,nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),similar to other nitrite extrusion proteins e.g. NARU_ECOLI|P37758 nitrite extrusion protein 2 from Escherichia coli (462 aa), FASTA scores: opt: 630, E(): 4.4e-33, (38.9% identity in 463 aa overlap); and NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 607, E(): 1.3e-31, (42.0% identity in 457 aa overlap). Also similar to Rv0261c, Rv2329c, Rv1737c, and to MLCB22_25 from Mycobacterium leprae (517 aa), FASTA score: (35.1 identity in 459 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS. Q7U2E9 No cell wall and cell processes Rv0267 NC_002945.3 Mycobrowser_v2 CDS 321663 322856 . - 0 Mb0275c CONSERVED HYPOTHETICAL PROTEIN Mb0275c, -, len: 397 aa. Equivalent to Rv0269c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Conserved hypothetical protein, highly similar to AL079355|SC4C6_19 hypothetical protein from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1019, E(): 0, (46.5% identity in 344 aa overlap), and similar to other proteins e.g. CAC49016.1|AL603644 putative ATP-dependent DNA ligase protein from Sinorhizobium meliloti (636 aa); O34398 YKOU PROTEIN from Bacillus subtilis (611 aa), FASTA score: (27.2% identity in 283 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3062,Rv3731 (both DNA ligases), and Rv0938, Rv3730c. Q7U2E7 No conserved hypotheticals Rv0269c NC_002945.3 Mycobrowser_v2 CDS 322892 324574 . + 0 Mb0276 fadD2 PROBABLE FATTY-ACID-COA LIGASE FADD2 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0276, fadD2, len: 560 aa. Equivalent to Rv0270,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable fadD2,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 544,E(): 2.9e-26, (27.7% identity in 535 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY493_2, MTCY8D5_9, MTCY6G11_8, etc. Contains PS00455 Putative AMP-binding domain signature. Q7U2E6 No NC_002945.3 Mycobrowser_v2 CDS 1455607 1456260 . + 0 Mb1333 conserved protein Mb1333, -, len: 217 aa. Equivalent to Rv1301, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Conserved hypothetical protein, highly similar to YRFE_MYCLE|P45831 hypothetical 22.7 kd protein in rfe-hemk intergenic region, (220 aa),FASTA scores: opt: 1168, E(): 0, (82.8% identity in 215 aa overlap). Contains PS01147 Hypothetical SUA5/yciO/yrdC family signature. BELONGS TO THE SUA5/YRDC/YCIO/YWLC FAMILY. Q7U085 No conserved hypotheticals Rv1301 NC_002945.3 Mycobrowser_v2 CDS 324591 326786 . - 0 Mb0277c fadE6 PROBABLE ACYL-COA DEHYDROGENASE FADE6 Mb0277c, fadE6, len: 731 aa. Equivalent to Rv0271c,len: 731 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 731 aa overlap). Probable fadE6,acyl-CoA dehydrogenase (EC 1.3.99.-), with C-terminal half similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase (short-chain) from Homo sapiens (412 aa),FASTA scores: opt: 339, E(): 1.3e-13, (28.1% identity in 288 aa overlap). Q7U2E5 No NC_002945.3 Mycobrowser_v2 CDS 326900 328033 . - 0 Mb0278c unknown protein Mb0278c, -, len: 377 aa. Equivalent to Rv0272c,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 377 aa overlap). Hypothetical unknown protein. Q7U2E4 No conserved hypotheticals Rv0272c NC_002945.3 Mycobrowser_v2 CDS 331762 332004 . - 0 Mb0284c PE_PGRS3b PE-PGRS FAMILY PROTEIN [SECOND PART] Mb0284c, PE_PGRS3b, len: 80 aa. Equivalent to 3' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 79 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0,(67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. No NC_002945.3 Mycobrowser_v2 CDS 331827 334433 . - 0 Mb0285c PE_PGRS3a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb0285c, PE_PGRS3a, len: 868 aa. Similar to 5' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (80.7% identity in 888 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Q7U2D8 No NC_002945.3 Mycobrowser_v2 CDS 334697 337330 . - 0 Mb0286c PE_PGRS3 PE-PGRS FAMILY PROTEIN Mb0286c, PE_PGRS3, len: 877 aa. Equivalent to Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0,(67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa). Q7U2D7 No NC_002945.3 Mycobrowser_v2 CDS 337580 340075 . - 0 Mb0287c PE_PGRS4 pe-pgrs family protein pe_pgrs4 Mb0287c, PE_PGRS4, len: 831 aa. Equivalent to Rv0279c, len: 837 aa, from Mycobacterium tuberculosis strain H37Rv, (97.4% identity in 837 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv0278c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 2677, E(): 0, (64.5% identity in 926 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions each of 9 bp (ccgccggcg-* and cccgccggc-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa). Q7U2D6 No NC_002945.3 Mycobrowser_v2 CDS 419322 419975 . + 0 Mb0356 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0356, -, len: 217 aa. Equivalent to Rv0348, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Possible transcriptional regulator, showing some similarity to O53334|RV3188|MTV014.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (115 aa), FASTA score: (30.0% identity in 100 aa overlap). Contains probable helix-turn helix motif from aa 89-110 (Score 1407, +3.98 SD). Q7U274 No regulatory proteins Rv0348 NC_002945.3 Mycobrowser_v2 CDS 340366 341976 . + 0 Mb0288 PPE3 ppe family protein ppe3 Mb0288, PPE3, len: 536 aa. Equivalent to Rv0280,len: 536 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 536 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium tuberculosis (539 aa), FASTA scores: opt: 1131, E(): 0,(51.7% identity in 540 aa overlap). Q7U2D5 No PE/PPE Rv0280 NC_002945.3 Mycobrowser_v2 CDS 342000 342908 . + 0 Mb0289 possible s-adenosylmethionine-dependent methyltransferase Mb0289, -, len: 302 aa. Equivalent to Rv0281, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Conserved hypothetical protein; member of Mycobacterium tuberculosis protein family that includes Rv0726c, Rv0731c, Rv3399,Rv1729c, etc. MTCY31_23 (325 aa), FASTA scores: opt: 1386,E(): 0, (69. 1% identity in 301 aa overlap). Contains possible N-terminal signal sequence. X2BEG3,Q7U2D4 No lipid metabolism Rv0281 NC_002945.3 Mycobrowser_v2 CDS 343132 345027 . + 0 Mb0290 ecca3 esx conserved component ecca3. esx-3 type vii secretion system protein. Mb0290, -, len: 631 aa. Equivalent to Rv0282, len: 631 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 631 aa overlap). Conserved hypothetical protein, similar to Y14967|MLCB628.18c hypothetical protein from Mycobacterium leprae (573 aa), FASTA scores: opt: 916, E(): 0, (38.7% identity in 568 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Z94121|MTY15F10.26 (619 aa), FASTA scores: opt: 743, E(): 0, (29.9% identity in 612 aa overlap). Member of CFXQ,CBXP family - 9 members in Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2D3 No cell wall and cell processes Rv0282 NC_002945.3 Mycobrowser_v2 CDS 386203 386973 . - 0 Mb0325c glpQ2 possible glycerophosphoryl diester phosphodiesterase glpq2 (glycerophosphodiester phosphodiesterase) Mb0325c, glpQ2, len: 256 aa. Equivalent to Rv0317c,len: 256 aa (start uncertain, chosen by homology), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 256 aa overlap). Possible glpQ2, glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46), similar to others e.g. E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl diester phosphodiesterase from Deinococcus radiodurans (285 aa); P10908|UGPQ_ECOLI from Escherichia coli (247 aa), FASTA scores: opt: 220, E(): 5.2e-07, (28.0% identity in 250 aa overlap). Also similar to MTCY01A6.27 from Mycobacterium tuberculosis FASTA score: (27.5% identity in 247 aa overlap). Q7U2A0 No NC_002945.3 Mycobrowser_v2 CDS 2196500 2196907 . - 0 Mb1997c vapc35 possible toxin vapc35. contains pin domain. Mb1997c, -, len: 135 aa. Equivalent to Rv1962c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv3408|MTCY78.20c (133 aa) (36.2% identity in 138 aa overlap); and Rv3384c (130 aa) (43.1% identity in 130 aa overlap) Q7TZ71 No virulence, detoxification, adaptation Rv1962c NC_002945.3 Mycobrowser_v2 CDS 345024 346640 . + 0 Mb0291 eccb3 esx conserved component eccb3. esx-3 type vii secretion system protein. possible membrane protein. Mb0291, -, len: 538 aa. Equivalent to Rv0283, len: 538 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 538 aa overlap). Possible conserved membrane protein, similar to several hypothetical mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 698, E(): 0, (37.6% identity in 492 aa overlap); Rv1782; Rv3450c; Rv3869; and Y14967|MLCB628_16|MLCB628.17c from Mycobacterium leprae (481 aa), FASTA scores: opt: 672, E(): 1.5e-31, (37.2% identity in 506 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2D2 No cell wall and cell processes Rv0283 NC_002945.3 Mycobrowser_v2 CDS 346637 350629 . + 0 Mb0292 eccc3 esx conserved component eccc3. esx-3 type vii secretion system protein. possible membrane protein. Mb0292, -, len: 1330 aa. Equivalent to Rv0284, len: 1330 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1330 aa overlap). Possible conserved membrane protein, similar to products of two adjacent Mycobacterium leprae genes, MLCB628.16c (744 aa) and MLCB628.15c (597 aa); and throughout its length to several large Mycobacterium tuberculosis proteins: Rv3447c,Rv3870, Rv1784, etc. Y14967|MLCB628_ 15 (744 aa), FASTA scores: opt: 942, E(): 0, (33.8% identity in 730 aa overlap); Y14967|MLCB628_14 (597 aa), FASTA scores: opt: 613, E(): 3.1e-30, (31.7% identity in 615 aa overlap); Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap); Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap). Contains three PS00017 ATP/GTP-binding site motif A (P-loop). Q7U2D1 No cell wall and cell processes Rv0284 NC_002945.3 Mycobrowser_v2 CDS 350626 350934 . + 0 Mb0293 PE5 pe family protein pe5 Mb0293, PE5, len: 102 aa. Equivalent to Rv0285,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below), similar to others e.g. AL0212|MTV012_37 from Mycobacterium tuberculosis (105 aa), FASTA scores: opt: 497, E(): 2.6e-24, (80.4% identity in 102 aa overlap); Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity in 102 aa overlap); etc. Q7U2D0 No PE/PPE Rv0285 NC_002945.3 Mycobrowser_v2 CDS 350937 352478 . + 0 Mb0294 PPE4 ppe family protein ppe4 Mb0294, PPE4, len: 513 aa. Equivalent to Rv0286,len: 513 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 513 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 958, E(): 0, (43.5% identity in 522 aa overlap). Q7U2C9 No PE/PPE Rv0286 NC_002945.3 Mycobrowser_v2 CDS 2130400 2130711 . + 0 Mb1925 PROBABLE MEMBRANE PROTEIN Mb1925, -, len: 103 aa. Equivalent to Rv1892, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Probable membrane protein. Q7TZC5 No cell wall and cell processes Rv1892 NC_002945.3 Mycobrowser_v2 CDS 352527 352820 . + 0 Mb0295 esxG esat-6 like protein esxg (conserved protein tb9.8) Mb0295, esxG, len: 97 aa. Equivalent to Rv0287,len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). esxG, conserved hypothetical protein. PE-family related protein; distant member of the Mycobacterium tuberculosis PE family,similar to Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt: 564, E(): 0, (91.8% identity in 97 aa overlap). Contains probable helix-turn-helix motif at aa 14-35 (Score 144, +4.11 SD). SEEMS TO BELONG TO THE ESAT6 FAMILY (see third citation below). Q7U2C8 No cell wall and cell processes Rv0287 NC_002945.3 Mycobrowser_v2 CDS 352850 353140 . + 0 Mb0296 esxH low molecular weight protein antigen 7 esxh (10 kda antigen) (cfp-7) (protein tb10.4) Mb0296, esxH, len: 96 aa. Equivalent to Rv0288,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). esxH (alternate gene name: TB10.4), low molecular weight protein antigen 7 (10 kDa antigen) (CFP-7) (Protein TB10.4) (see citations below), ala-rich protein; member of mycobacterial protein family containing ESAT-6, very similar to MTV012_33 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 566, E(): 0, (84.4% identity in 96 aa overlap). Alternative start codon possible position 351878 (see second citation). BELONG TO THE ESAT6 FAMILY (see first,sixth and seventh citations below). X2BEL4 No cell wall and cell processes Rv0288 NC_002945.3 Mycobrowser_v2 CDS 353151 354038 . + 0 Mb0297 espg3 esx-3 secretion-associated protein espg3 Mb0297, -, len: 295 aa. Equivalent to Rv0289, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Conserved hypothetical protein, equivalent to CAC32061.1|AL583926 possible DNA-binding protein from Mycobacterium leprae (289 aa); and showing some similarity to Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from Mycobacterium tuberculosis (276 aa), FASTA scores: opt: 149, E(): 0.0035, (27.7% identity in 289 aa overlap). Q7U2C7 No cell wall and cell processes Rv0289 NC_002945.3 Mycobrowser_v2 tRNA 387234 387304 . - 0 glyU glyU tRNA-Gly glyU, len: 71 nt. Equivalent to glyU, len: 71 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 nt overlap). tRNA-Gly, anticodon ccc. No NC_002945.3 Mycobrowser_v2 CDS 354085 355503 . + 0 Mb0298 eccd3 esx conserved component eccd3. esx-3 type vii secretion system protein. probable transmembrane protein. Mb0298, -, len: 472 aa. Equivalent to Rv0290, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable conserved transmembrane protein, similar to several others in mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from Mycobacterium tuberculosis (467 aa), FASTA scores: opt: 429, E(): 5.1e-19, (28. 6% identity in 479 aa overlap); Rv3877; Rv1795; Rv3448; and Y14967|MLCB628_9|MLCB628.10c from Mycobacterium leprae (480 aa), FASTA scores: opt: 269, E(): 3.1e-09, (26.0% identity in 503 aa overlap). TBparse score is 0.892. Q7U2C6 No cell wall and cell processes Rv0290 NC_002945.3 Mycobrowser_v2 CDS 355500 356885 . + 0 Mb0299 mycp3 probable membrane-anchored mycosin mycp3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) Mb0299, -, len: 461 aa. Equivalent to Rv0291, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable protease precursor (EC 3.4.-.-), similar to several others in mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from Mycobacterium leprae (446 aa), FASTA scores: opt: 1159,E(): 0, (43.5 identity in 446 aa overlap). Has signal sequence and hydrophobic stretch at C-terminus, followed by short positively charged segment, that could act as membrane anchor. Shows similarity to several members of the subtilase family and contains PS00137 Serine proteases, subtilase family, histidine active site signature. Q7U2C5 No intermediary metabolism and respiration Rv0291 NC_002945.3 Mycobrowser_v2 CDS 356882 357877 . + 0 Mb0300 ecce3 esx conserved component ecce3. esx-3 type vii secretion system protein. probable transmembrane protein. Mb0300, -, len: 331 aa. Equivalent to Rv0292, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 331 aa overlap). Probable conserved transmembrane protein (has two hydrophobic segments at N-terminal end), equivalent to CAC32058.1|AL583926 conserved membrane protein from Mycobacterium leprae (339 aa). Q7U2C4 No cell wall and cell processes Rv0292 NC_002945.3 Mycobrowser_v2 CDS 357864 359066 . - 0 Mb0301c conserved protein Mb0301c, -, len: 400 aa. Equivalent to Rv0293c,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 400 aa overlap). Conserved hypothetical protein, similar in C-terminal part to Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (413 aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity in 299 aa overlap). TBparse score is 0.922. Q7U2C3 No conserved hypotheticals Rv0293c NC_002945.3 Mycobrowser_v2 CDS 359173 359958 . + 0 Mb0302 tam PROBABLE TRANS-ACONITATE METHYLTRANSFERASE TAM Mb0302, tam, len: 261 aa. Equivalent to Rv0294,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 261 aa overlap). Probable tam,trans-aconitate methyltransferase (EC 2.1.1.-), similar to others e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 TRANS-ACONITATE METHYLTRANSFERASE from Escherichia coli strain K12 (252 aa), FASTA scores: opt: 649, E(): 0, (39.3 identity in 252 aa overlap). BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. X2BEL6,P66886 No intermediary metabolism and respiration Rv0294 NC_002945.3 Mycobrowser_v2 CDS 359947 360750 . - 0 Mb0303c conserved protein Mb0303c, -, len: 267 aa. Equivalent to Rv0295c,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 267 aa overlap). Conserved hypothetical protein, showing weak similarity with CAC46877.1|AL591790 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (213 aa); and NP_104818.1|14023999|BAB50604.1|AP00300 Protein with weak similarity to NodH from Mesorhizobium loti (257 aa). Q7U2C2 No conserved hypotheticals Rv0295c NC_002945.3 Mycobrowser_v2 CDS 387335 388129 . - 0 Mb0326c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0326c, -, len: 264 aa. Equivalent to Rv0318c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable conserved integral membrane protein, with some similarity to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: opt: 157, E (): 0.0032, (28.3% identity in 198 aa overlap). Also similar to O26573 CONSERVED PROTEIN from Methanobacterium thermoauto (259 aa), FASTA scores: opt: 173, E(): 5.2e-05, (32.7% identity in 214 aa overlap). Q7U299 No cell wall and cell processes Rv0318c NC_002945.3 Mycobrowser_v2 CDS 4320326 4320775 . - 0 Mb3931c POSSIBLE MEMBRANE PROTEIN Mb3931c, -, len: 149 aa. Equivalent to Rv3901c,len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 149 aa overlap). Possible membrane protein (hydrophobic stretch from ~30-52), showing some similarity with O53200|Rv2473|MTV008.29 HYPOTHETICAL 25.1 KDA PROTEIN from Mycobacterium tuberculosis (238 aa),FASTA scores: opt: 147, E(): 0.036, (31.35% identity in 134 aa overlap). Q7TVE0 No cell wall and cell processes Rv3901c NC_002945.3 Mycobrowser_v2 CDS 360760 362157 . - 0 Mb0304c PROBABLE SULFATASE Mb0304c, -, len: 465 aa. Equivalent to Rv0296c,len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 465 aa overlap). Probable sulfatase,possibly an aryl-/steryl-sulfatase (EC 3.1.6.-) or a sulfamidase (sulfohydrolase) (sulphamidase) (EC 3.10.1.-). Similar to various hydrolases e.g. AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus musculus (502 aa); NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 N-sulfoglucosamine sulfohydrolase (sulfamidase) (sulphamidase) from Mus musculus (502 aa); AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC) from Homo sapiens (583 aa); ARSB_FELCA|P33727 arylsulfatase B precursor (EC 3.1.6.1) (535 aa), FASTA scores: opt: 231, E(): 1.7e-08, (30.3% identity in 261 aa overlap). Also similarity with 4 others sulfatases in Mycobacterium tuberculosis. Contains sulfatases signature 1 (PS00523). Note that previously known as atsG. Q7U2C1 No intermediary metabolism and respiration Rv0296c NC_002945.3 Mycobrowser_v2 CDS 362336 364156 . + 0 Mb0305 PE_PGRS5 pe-pgrs family protein pe_pgrs5 Mb0305, PE_PGRS5, len: 606 aa. Equivalent to Rv0297, len: 591 aa, from Mycobacterium tuberculosis strain H37Rv, (97.5% identity in 606 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Y03A_MYCTU|Q10637 from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 1884, E(): 0, (53.7% identity in 635 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa). Q7U2C0 No PE/PPE Rv0297 NC_002945.3 Mycobrowser_v2 CDS 364299 364526 . + 0 Mb0306 HYPOTHETICAL PROTEIN Mb0306, -, len: 75 aa. Equivalent to Rv0298, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Hypothetical unknown protein. Q7U2B9 No conserved hypotheticals Rv0298 NC_002945.3 Mycobrowser_v2 CDS 365652 366284 . + 0 Mb0310 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY) Mb0310, -, len: 210 aa. Equivalent to Rv0302, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 210 aa overlap). Probable transcription regulatory protein, TetR family, with its N-terminus similar to N-terminus of several repressors and regulatory proteins of TetR/AcrR family e.g. ACRR_ECOLI|P34000 potential acraB operon repressor from Escherichia coli (215 aa), FASTA scores: opt: 172, E(): 3.1e-05, (22.7% identity in 194 aa overlap). Also similar in N-terminus to N-terminus of MTCY07A7.24 hypothetical regulator from Mycobacterium tuberculosis FASTA score: (38.7% identity in 62 aa overlap). Contains probable helix-turn helix motif from aa 35-56 (Score 1728, +5.07 SD). Q7U2B5 No regulatory proteins Rv0302 NC_002945.3 Mycobrowser_v2 CDS 366281 367189 . + 0 Mb0311 PROBABLE DEHYDROGENASE/REDUCTASE Mb0311, -, len: 302 aa. Equivalent to Rv0303, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various NADPH dehydrogenases and other NADPH oxidoreductases e.g. O48741|PORC_ARATH|7488284|T00897 PROTOCHLOROPHYLLIDE REDUCTASE C CHLOROPLAST PRECURSOR (EC 1.3.1.33) (NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE C) from Arabidopsis thaliana (401 aa); Q42850 NADPH DEHYDROGENASE (EC 1.6.99. 1) (395 aa), FASTA scores: opt: 347, E(): 3.8e-16, (35.4% identity in 319 aa overlap). Q7U2B4 No intermediary metabolism and respiration Rv0303 NC_002945.3 Mycobrowser_v2 CDS 370784 376741 . - 0 Mb0313c PPE6 ppe family protein ppe6 Mb0313c, PPE6, len: 1985 aa. Equivalent to 5' end of Rv0305c, len: 963 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 809 aa overlap). Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Y04H_MYCTU|Q10778 from M. tuberculosis (734 aa), FASTA scores: opt: 1340, E(): 0,(40.9% identity in 815 aa overlap); Z95324|MTY13E10_16 from Mycobacterium tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0, (42.3% identity in 522 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis, a single base deletion (t-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Q7U2B2 No NC_002945.3 Mycobrowser_v2 CDS 376944 377615 . + 0 Mb0314 PUTATIVE OXIDOREDUCTASE Mb0314, -, len: 223 aa. Equivalent to Rv0306, len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Putative oxidoreductase (EC 1.-.-.-), highly similar to H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved hypothetical protein from Pseudomonas aeruginosa strain PAO1 (218 aa); and to other putative oxidoreductases e.g. middle part of CAB76073.1|AL157953 putative nitroreductase from Streptomyces coelicolor (1212 aa); Q52685|BLUB protein involved in cobalamin (vitamin B12) synthesis from Rhodobacter capsulatus (206 aa), FASTA scores: opt: 318,E(): 2e-15, (35.6% identity in 191 aa overlap). Q7U2B1 No intermediary metabolism and respiration Rv0306 NC_002945.3 Mycobrowser_v2 CDS 377603 378085 . - 0 Mb0315c unknown protein Mb0315c, -, len: 160 aa. Equivalent to Rv0307c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein. Q7U2B0 No conserved hypotheticals Rv0307c NC_002945.3 Mycobrowser_v2 CDS 378143 378859 . + 0 Mb0316 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0316, -, len: 238 aa. Equivalent to Rv0308, len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Probable conserved integral membrane protein, with C-terminus highly similar to C-terminus of other integral membrane proteins or phosphatases e.g. AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 putative phosphatase from Streptococcus pyogenes (201 aa); Q06074 HYPOTHETICAL 24.9 KD PROTEIN (216 aa), FASTA scores: opt: 209, E(): 2e-07, (27.9% identity in 140 aa overlap). Could be a phosphatase. Q7U2A9 No cell wall and cell processes Rv0308 NC_002945.3 Mycobrowser_v2 CDS 378961 379617 . + 0 Mb0317 POSSIBLE CONSERVED EXPORTED PROTEIN Mb0317, -, len: 218 aa. Equivalent to Rv0309, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Possible conserved exported protein (has putative N-terminal signal sequence), equivalent to AC32053.1|AL583926 putative secreted protein from Mycobacterium leprae (218 aa). Also similar to others e.g. AB76092.1|AL157956 putative secreted protein from Streptomyces coelicolor (238 aa). Q7U2A8 No cell wall and cell processes Rv0309 NC_002945.3 Mycobrowser_v2 CDS 379687 380178 . - 0 Mb0318c conserved protein Mb0318c, -, len: 163 aa. Equivalent to Rv0310c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 BILE ACID-INDUCIBLE OPERON PROTEIN E from Eubacterium sp (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% identity in 134 aa overlap); AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa). Q7U2A7 No conserved hypotheticals Rv0310c NC_002945.3 Mycobrowser_v2 CDS 390290 391621 . + 0 Mb0330 udgA PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH) Mb0330, udgA, len: 443 aa. Equivalent to Rv0322,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 443 aa overlap). Probable udg (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase (EC 1.1.1.22), highly similar to others e.g. CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase from Streptomyces coelicolor (447 aa); Q56812 UDP-GLUCOSE DEHYDROGENASE from Xanthomonas campestris (445 aa), FASTA scores: opt: 713, E(): 0, (41.9% identity in 351 aa overlap); etc. Also similar to several GDP-mannose 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UDP-GLUCOSE/GDP-MANNOSE DEHYDROGENASES FAMILY. Q7U296 No intermediary metabolism and respiration Rv0322 NC_002945.3 Mycobrowser_v2 CDS 381586 383448 . + 0 Mb0320 CONSERVED HYPOTHETICAL PROLINE AND THREONINE RICH PROTEIN Mb0320, -, len: 620 aa. Equivalent to Rv0312, len: 620 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 620 aa overlap). Conserved hypothetical protein with highly Pro-, Thr-rich C-terminus. Similar to Pro-,Thr-rich region in Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis (592 aa), FASTA scores: opt: 1075, E(): 0, (38.9% identity in 627 aa overlap). Also some similarity with Rv0350|dnaK from Mycobacterium tuberculosis. Possibly membrane protein; has hydrophobic stetch in its middle part. Q7U2A5 No conserved hypotheticals Rv0312 NC_002945.3 Mycobrowser_v2 CDS 388178 388846 . + 0 Mb0327 pcp PROBABLE PYRROLIDONE-CARBOXYLATE PEPTIDASE PCP (5-OXOPROLYL-PEPTIDASE) (PYROGLUTAMYL-PEPTIDASE I) (PGP-I) (PYRASE) Mb0327, pcp, len: 222 aa. Equivalent to Rv0319,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable pcp,pyrrolidone-carboxylate peptidase (EC 3.4.19.3), highly similar to others e.g. PCP_PSEFL|P42673 pyrrolidone-carboxylate peptidase from Pseudomonas fluorescens (213 aa), FASTA scores: opt: 478, E(): 7.5e-25, (40.2% identity in 219 aa overlap). BELONGS TO PEPTIDASE FAMILY C15 (THIOL PROTEASE). X2BEP1,P0A5R5 No intermediary metabolism and respiration Rv0319 NC_002945.3 Mycobrowser_v2 CDS 388918 389580 . + 0 Mb0328 POSSIBLE CONSERVED EXPORTED PROTEIN Mb0328, -, len: 220 aa. Equivalent to Rv0320, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Possible conserved exported protein, similar to some hypothetical proteins and to the middle part of a peptidase: NP_066789.1|10657900|AAG21739.1|AF116907 putative peptidase from Rhodococcus equi (546 aa). Also similar to Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity in 225 aa overlap). Q7U298 No cell wall and cell processes Rv0320 NC_002945.3 Mycobrowser_v2 CDS 389612 390184 . + 0 Mb0329 dcd PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) Mb0329, dcd, len: 190 aa. Equivalent to Rv0321,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 190 aa overlap). Probable dcd (alterrnate gene names: dus or paxA), deoxycytidine triphosphate deaminase (EC 3.5.4.13), equivalent to CAC32024.1|AL583925 probable deoxycytidine triphosphate deaminase from Mycobacterium leprae (190 aa). Also highly similar to others e.g. Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE from Streptomyces coelicolor (191 aa); DCD_ECOLI|P28248|DUS|PAXA|B2065 DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE from Escherichia coli strain K12 (193 aa), FASTA scores: opt: 408, E(): 2.7e-21, (43.1% identity in 188 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE DCTP DEAMINASE FAMILY. X2BEL5,Q7U297 No intermediary metabolism and respiration Rv0321 NC_002945.3 Mycobrowser_v2 CDS 391610 392281 . - 0 Mb0331c CONSERVED HYPOTHETICAL PROTEIN Mb0331c, -, len: 223 aa. Equivalent to Rv0323c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 223 aa overlap). Conserved hypothetical protein, similar to others e.g. YPJG_BACSU|P42981 hypothetical 24.8 kd protein from Bacillus subtilis (224 aa), FASTA scores: opt: 182, E(): 1.3e-05, (27.5% identity in 211 aa overlap). Also some similarity to MLU15183_8 from Mycobacterium tuberculosis FASTA score: (32.0% identity in 147 aa overlap). Q7U295 No conserved hypotheticals Rv0323c NC_002945.3 Mycobrowser_v2 CDS 392382 393062 . + 0 Mb0332 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY) Mb0332, -, len: 226 aa. Equivalent to Rv0324, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Possible transcriptional regulator, arsR family, with its N-terminus similar to the N-terminus of other DNA-binding proteins e.g. P30346|MERR_STRLI probable mercury resistance operon from Streptomyces lividans (125 aa),FASTA scores: opt: 154, E(): 0.002, (32.2% identity in 90 aa overlap)), and its C-terminal part similar to hypothetical bacterial proteins e.g. P54510|YQHL_BACSU hypothetical 14.6 kd protein from Bacillus subtilis (126 aa), FASTA scores: opt: 159, E(): 0.00097, (35.5% identity in 76 aa overlap)). Most similar to AJ005575|SPE005575_2 ORF1 required for antibiotic production from Streptomyces peucetius (226 aa), FASTA scores: opt: 816, E(): 0, (60.7% identity in 211 aa overlap). Also similar in C-terminus to MTCY164.26 molybdopterin biosynthesis moeb protein from Mycobacterium tuberculosis FASTA score: (36.8% identity in 114 aa overlap). Q7U294 No regulatory proteins Rv0324 NC_002945.3 Mycobrowser_v2 CDS 393069 393758 . + 0 Mb0333 HYPOTHETICAL PROTEIN Mb0333, -, len: 229 aa. Equivalent to Rv0325 and Rv0326, len: 74 aa and 151 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 aa overlap and 100.0% identity in 151 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (t-c) leads to single product. Q7U293 No unknown Rv0325 NC_002945.3 Mycobrowser_v2 CDS 393726 395075 . - 0 Mb0334c cyp135A1 POSSIBLE CYTOCHROME P450 135A1 CYP135A1 Mb0334c, cyp135A1, len: 449 aa. Equivalent to Rv0327c, len: 449 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 449 aa overlap). Possible cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() : 1.7e-11, (27.9% identity in 433 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in 434 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. Alternative start possible at 33706 but no RBS. Q7U292 No NC_002945.3 Mycobrowser_v2 CDS 399688 400554 . + 0 Mb0341 rmlA alpha-d-glucose-1-phosphate thymidylyltransferase rmla (dtdp-glucose synthase) (dtdp-glucose pyrophosphorylase) Mb0341, rmlA, len: 288 aa. Equivalent to Rv0334,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap). Probable rmlA (alternate gene name: rfbA), glucose-1-phosphate thymidylyl-transferase (EC 2.7.7.24), equivalent to CAC32020.1|AL583925 glucose-1-phosphate thymidyltransferase from Mycobacterium leprae (288 aa). Also highly similar to others e.g. AAG29804.1|AF235050 glucose-1-phosphate thymidylyltransferase from Streptomyces rishiriensis (296 aa); RBA1_ECOLI|P37744 glucose-1-phosphate thymidylyltransferase from Escherichia coli strain K12 (293 aa), FASTA scores: opt: 1199, E(): 0,(62.0% identity in 284 aa overlap). BELONGS TO THE GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE FAMILY. Q7U285 No intermediary metabolism and respiration Rv0334 NC_002945.3 Mycobrowser_v2 CDS 395141 395743 . + 0 Mb0335 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR/ACRR-FAMILY) Mb0335, -, len: 200 aa. Equivalent to Rv0328, len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Possible transcription regulator, tetR/acrR family, similar in part to various hypothetical transcriptional regulators e.g. T36696|4726006|CAB41735.1|AL049731 probable regulatory protein from Streptomyces coelicolor (197 aa). Also some similarity with YX44_MYCTU|Q10829 hypothetical transcriptional regulator from Mycobacterium tuberculosis (195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7% identity in 202 aa overlap). Contains probable helix-turn helix motif from aa 27-48 (Score 1408, +3.98 SD). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U291 No regulatory proteins Rv0328 NC_002945.3 Mycobrowser_v2 CDS 395724 396350 . - 0 Mb0336c CONSERVED HYPOTHETICAL PROTEIN Mb0336c, -, len: 208 aa. Equivalent to Rv0329c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 208 aa overlap). Conserved hypothetical protein, showing some similarity with others hypothetical proteins and methyltransferases e.g. MitM|AF127374_14 methyltransferase from Streptomyces lavendulae (283 aa),FASTA scores: opt: 242, E(): 1.8e-08, (37.2% identity in 145 aa overlap); Q48938 from Methanosarcina barkeri (262 aa), FASTA scores: opt: 194, E(): 3.6e-06, (31.1% identity in 119 aa overlap). Q7U290 No conserved hypotheticals Rv0329c NC_002945.3 Mycobrowser_v2 CDS 397231 398397 . + 0 Mb0338 POSSIBLE DEHYDROGENASE/REDUCTASE Mb0338, -, len: 388 aa. Equivalent to Rv0331, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein reductase from Mesorhizobium loti (377 aa); NP_147681.1 predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% identity in 348 aa overlap). TBparse score is 0.906. Q7U288 No intermediary metabolism and respiration Rv0331 NC_002945.3 Mycobrowser_v2 CDS 398472 399257 . + 0 Mb0339 conserved protein Mb0339, -, len: 261 aa. Equivalent to Rv0332, len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 261 aa overlap). Conserved hypothetical protein, similar to several conserved hypothetical proteins from Streptomyces coelicolor e.g. SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% identity in 251 aa overlap). Q7U287 No conserved hypotheticals Rv0332 NC_002945.3 Mycobrowser_v2 CDS 399284 399658 . + 0 Mb0340 unknown protein Mb0340, -, len: 124 aa. Equivalent to Rv0333, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Hypothetical unknown protein. Q7U286 No conserved hypotheticals Rv0333 NC_002945.3 Mycobrowser_v2 CDS 401222 402733 . + 0 Mb0343 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0343, -, len: 503 aa. Equivalent to Rv0336, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Part of Mycobacterium tuberculosis 13E12 repeat family; almost identical to Rv0515|MTCY20G10.05 hypothetical protein from M. tuberculosis FASTA scores: (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1148c, Rv1945, etc. Q7TTD9 No insertion seqs and phages Rv0336 NC_002945.3 Mycobrowser_v2 CDS 402903 404192 . - 0 Mb0344c aspC PROBABLE ASPARTATE AMINOTRANSFERASE ASPC (TRANSAMINASE A) (ASPAT) Mb0344c, aspC, len: 429 aa. Equivalent to Rv0337c,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Probable aspC,aspartate aminotransferase (transaminase A) (EC 2.6.1.1),equivalent to CAC32019.1|AL583925 probable aspartate aminotransferase from Mycobacterium leprae (437 aa). Also highly similar to many e.g. Q48143|U32823 aspartate aminotransferase (404 aa), FASTA scores: opt: 1646, E(): 0, (57.2% identity in 404 aa overlap). Also some similarity to Rv3565|MTCY06G11.12 from Mycobacterium tuberculosis FASTA score: (27.2% identity in 383 aa overlap). BELONGS TO CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BEM9,P63499 No NC_002945.3 Mycobrowser_v2 CDS 404223 406871 . - 0 Mb0345c probable iron-sulfur-binding reductase Mb0345c, -, len: 882 aa. Equivalent to Rv0338c,len: 882 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 882 aa overlap). Probable iron-sulphur-binding reductase (EC 1.-.-.-), possibly membrane-bound, equivalent to CAC32018.1|AL583925 probable iron-sulphur-binding reductase from Mycobacterium leprae (880 aa). Also highly similar to others e.g. T36608|5019323|CAB44376.1|AL078610 probable iron-sulfur-binding reductase from Streptomyces coelicolor (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity in 772 aa overlap); BAB07521.1|AP001520 iron-sulphur-binding reductase from Bacillus halodurans (700 aa). Contains PS00070 Aldehyde dehydrogenases cysteine active site and two of PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. First of several possible start sites chosen. Q7U283 No intermediary metabolism and respiration Rv0338c NC_002945.3 Mycobrowser_v2 CDS 406980 409478 . - 0 Mb0346c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0346c, -, len: 832 aa. Equivalent to Rv0339c,len: 832 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 832 aa overlap). Possible transcriptional regulator, showing very weak similarity with parts of others. Contains PS00017 ATP/GTP-binding site motif A (P-loop ); and probable helix-turn helix motif from aa 778-799 (Score 1041, +2.73 SD). Q7U282 No regulatory proteins Rv0339c NC_002945.3 Mycobrowser_v2 CDS 409664 410203 . + 0 Mb0347 conserved protein Mb0347, -, len: 179 aa. Equivalent to Rv0340, len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Conserved hypothetical protein; MEME-MAST analysis shows similarity to product of downstream gene, Rv0341|iniB. Q7U281 No conserved hypotheticals Rv0340 NC_002945.3 Mycobrowser_v2 CDS 410392 411831 . + 0 Mb0348 iniB ISONIAZID INDUCTIBLE GENE PROTEIN INIB Mb0348, iniB, len: 479 aa. Equivalent to Rv0341,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). iniB,isoniazid-inducible gene, (see citations below). Protein very Gly-, Ala-rich, similar to cell wall proteins e.g. P27483|GRP_ARATH GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN from A.thaliana (338 aa), FASTA scores: opt: 532, E(): 5.2e-13, (39.3% identity in 321 aa overlap). MEME-MAST analysis shows similarity to product of upstream gene,Rv0340. Q7U280 No cell wall and cell processes Rv0341 NC_002945.3 Mycobrowser_v2 CDS 411868 413790 . + 0 Mb0349 iniA ISONIAZID INDUCTIBLE GENE PROTEIN INIA Mb0349, iniA, len: 640 aa. Equivalent to Rv0342,len: 640 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 640 aa overlap). iniA,isoniazid-inducible gene, (see citations below). Shows slight similarity to some hypothetical bacterial proteins e.g. P40983|YOR6_THER hypothetical protein (402 aa), FASTA scores: opt: 242, E(): 1.4e-07, (22.3% identity in 349 aa overlap). Also some similarity to downstream ORF Rv0343|iniC. Possible transmembrane stretch around residue 490. Alternative translational start at 410824. Contains a phosphopantetheine attachment site motif suggestive of an acyl carrier protein. Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid. Q7U279 No cell wall and cell processes Rv0342 NC_002945.3 Mycobrowser_v2 CDS 413787 415268 . + 0 Mb0350 iniC ISONIAZID INDUCTIBLE GENE PROTEIN INIC Mb0350, iniC, len: 493 aa. Equivalent to Rv0343,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 493 aa overlap). iniC,isoniazid-inducible gene, (see citations below). Shows slight similarity to P40983|YOR6_THER8 hypothetical protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05,(25.9% identity in 228 aa overlap). Also some similarity to upstream ORF Rv0342|iniA. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid. Q7U278 No cell wall and cell processes Rv0343 NC_002945.3 Mycobrowser_v2 CDS 415411 415971 . - 0 Mb0351c lpqJ PROBABLE LIPOPROTEIN LPQJ Mb0351c, lpqJ, len: 186 aa. Equivalent to Rv0344c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Probable lipoprotein,without homology. Has an appropriately positioned prokaryotic lipoprotein signature (PS00013). Q7U277 No NC_002945.3 Mycobrowser_v2 CDS 416217 416489 . + 0 Mb0353 CONSERVED HYPOTHETICAL PROTEIN Mb0353, -, len: 90 aa. Equivalent to 3' end of Rv0345, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 188, E(): 1.5e-05, (41.0% identity in 117 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U276 No NC_002945.3 Mycobrowser_v2 CDS 416531 417994 . - 0 Mb0354c ansP2 POSSIBLE L-ASPARAGINE PERMEASE ANSP2 (L-ASPARAGINE TRANSPORT PROTEIN) Mb0354c, ansP2, len: 487 aa. Equivalent to Rv0346c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 487 aa overlap). Possible ansP2,L-asparagine permease, integral membrane protein belonging to family containing many amino acid permeases, highly similar to G467030|B2126_F2_85|NP_301937.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (498 aa); and NP_301938.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (505 aa). Also highly similar to others e.g. P77610|ANSP_ECOLI L-ASPARAGINE PERMEASE from Escherichia coli strain K-12 (499 aa). Also highly similar to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 PROBABLE L-ASPARAGINE PERMEASE from Mycobacterium tuberculosis (489 aa), FASTA score: (72.1% identity in 473 aa overlap). And shows some similarity to MTCY3G12.14 from Mycobacterium tuberculosis. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Note that previously known as aroP2. X2BES8,P0A4W1 No NC_002945.3 Mycobrowser_v2 CDS 418333 419319 . + 0 Mb0355 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0355, -, len: 328 aa. Equivalent to Rv0347, len: 328 aa (alternative start possible), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 328 aa overlap). Probable conserved membrane protein, similar to Rv0831c|AL022004|MTV043_23 from Mycobacterium tuberculosis (271 aa), FASTA scores: E(): 9.6e-21, (33.1% identity in 266 aa overlap). Q7U275 No cell wall and cell processes Rv0347 NC_002945.3 Mycobrowser_v2 CDS 435847 436491 . - 0 Mb0363c conserved protein Mb0363c, -, len: 214 aa. Equivalent to Rv0356c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1067, E(): 0, (73.4% identity in 214 aa overlap). Q7U269 No conserved hypotheticals Rv0356c NC_002945.3 Mycobrowser_v2 CDS 420864 422741 . + 0 Mb0358 dnaK PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70) Mb0358, dnaK, len: 625 aa. Equivalent to Rv0350,len: 625 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 625 aa overlap). Probable DnaK (alternate gene name: hsp70), 70 kDa heat shock protein (see citations below), equivalent to AAA25362.1|M95576|1924344A|738248 heat shock protein 70 from Mycobacterium leprae (621 aa); and DNAK_MYCPA|Q00488 (623 aa), FASTA scores: opt: 3678, E(): 0, (92.3% identity in 625 aa overlap). Also highly similar to others e.g. Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 CHAPERONE PROTEIN DNAK from Streptomyces coelicolor (618 aa). Has probably an ATPase activity (EC 3.6.1.-). Note that this sequence differs from DNAK_MYCTU|P32723 (609 aa), due to a frameshift near the N-terminus. BELONGS TO THE HEAT SHOCK PROTEIN 70 FAMILY. X2BES1,P0A5C0 No virulence, detoxification, adaptation Rv0350 NC_002945.3 Mycobrowser_v2 CDS 422738 423445 . + 0 Mb0359 grpE PROBABLE GRPE PROTEIN (HSP-70 COFACTOR) Mb0359, grpE, len: 235 aa. Equivalent to Rv0351,len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 235 aa overlap). Probable grpE protein (HSP-70 COFACTOR), equivalent to CAC32012.1|AL583925 Hsp70 cofactor from Mycobacterium leprae (229 aa). Also highly similar to others eg Q05562|GRPE_STRCO|2127521|PN0643 GRPE PROTEIN from Streptomyces coelicolor (225 aa). Contains grpE protein signature (PS01071). BELONGS TO THE GRPE FAMILY. X2BET3,Q7U272 No virulence, detoxification, adaptation Rv0351 NC_002945.3 Mycobrowser_v2 CDS 423481 424668 . + 0 Mb0360 dnaJ1 PROBABLE CHAPERONE PROTEIN DNAJ1 Mb0360, dnaJ1, len: 395 aa. Equivalent to Rv0352,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 395 aa overlap). Probable DnaJ1,chaperone protein, equivalent to AAA25363.1|M95576 DNA J heatshock protein from Mycobacterium leprae (389 aa). Also highly similar to others. Contains both DnaJ signatures (PS00636, and PS00637). BELONGS TO THE DNAJ FAMILY. COFACTOR: BINDS TWO ZINC IONS PER MONOMER. Note that sequence differs from DNAJ_MYCTU|P07881 due to a frameshift at the N-terminus. Note that previously known as dnaJ. X2BEP4,P0A549 No NC_002945.3 Mycobrowser_v2 CDS 424668 425048 . + 0 Mb0361 hspR probable heat shock protein transcriptional repressor hspr (merr family) Mb0361, hspR, len: 126 aa. Equivalent to Rv0353,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Probable hspR, heat shock regulatory protein, merR family, highly similar to others e.g. HspR|P40183 heat shock regulatory protein from Streptomyces coelicolor (151 aa), FASTA scores: E(): 4.9e-22, (55.7% identity in 140 aa overlap), that binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon. Has possible coiled coil region in C-terminal half. BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U271 No virulence, detoxification, adaptation Rv0353 NC_002945.3 Mycobrowser_v2 CDS 425173 435696 . - 0 Mb0362c PPE8 ppe family protein ppe7 Mb0362c, PPE8, len: 3507 aa. Equivalent to Rv0355c and Rv0354c, len: 3300 aa and 141 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 3296 aa overlap and 100.0% identity in 125 aa overlap). PPE8,member of the Mycobacterium tuberculosis PPE family,similar to others e.g. AL009198|MTV004_5 from M. tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0,(40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17, E(): 0; MTCY98.0034c,E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; MTCY31.06c, E(): 5.6e-17; MTCY359.33, E(): 2.3e-16. PPE7,member of the Mycobacterium tuberculosis PPE family,similar to others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa), FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa overlap). Possible continuation of ORF upstream, but no sequence error apparent. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis, a 2 bp insertion (*-ta) resulting in the absence of a stop codon between the 2 genes, leads to a single product. Q7U270 No PE/PPE Rv0355c NC_002945.3 Mycobrowser_v2 CDS 443412 444095 . + 0 Mb0371 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0371, -, len: 227 aa. Equivalent to Rv0364, len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 227 aa overlap). Possible conserved transmembrane protein, equivalent to O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLCB 4_19 HYPOTHETICAL 24.3 KDA PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1% identity in 227 aa overlap). Shows strong similarity to DEDA_ECOLI|P09548 DedA PROTEIN protein from Escherichia coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa overlap). Similar also to Mycobacterium tuberculosis DedA protein Rv2637|MTCY441.0. Q7U263 No cell wall and cell processes Rv0364 NC_002945.3 Mycobrowser_v2 CDS 1015332 1015766 . + 0 Mb0934 CONSERVED HYPOTHETICAL PROTEIN Mb0934, -, len: 144 aa. Equivalent to Rv0910, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved hypothetical protein, equivalent to NP_302398.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa),FASTA scores: opt: 820, E(): 0, (83.9% identity in 143 aa overlap). Also similar to Rv1546|MTCY48.19c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (143 aa). Q7U119 No conserved hypotheticals Rv0910 NC_002945.3 Mycobrowser_v2 CDS 436488 437786 . - 0 Mb0364c purA PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE) Mb0364c, purA, len: 432 aa. Equivalent to Rv0357c,len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Probable purA,adenylosuccinate synthase (EC 6.3.4.4), equivalent to AL023514|MLCB4_13 from ADENYLOSUCCINATE SYNTHETASE Mycobacterium leprae (432 aa), FASTA scores: opt: 2555,E(): 0, (87.9% identity in 431 aa overlap). Also highly similar to many bacterial adenylosuccinates synthetases e.g. P12283|PURA_ECOLI adenylosuccinates synthetase from Escherichia coli (431 aa), FASTA scores: E(): 0, (51.1% identity in 425 aa overlap); etc. BELONGS TO THE ADENYLOSUCCINATE SYNTHETASE FAMILY. X2BET8,P65881 No NC_002945.3 Mycobrowser_v2 CDS 437877 438524 . + 0 Mb0365 conserved protein Mb0365, -, len: 215 aa. Equivalent to Rv0358, len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Conserved hypothetical protein, highly similar to AL023514|MLCB4_14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 852, E(): 0, (62.9% identity in 229 aa overlap). Q7U268 No conserved hypotheticals Rv0358 NC_002945.3 Mycobrowser_v2 CDS 438535 439314 . + 0 Mb0366 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0366, -, len: 259 aa. Equivalent to Rv0359, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 259 aa overlap). Probable conserved integral membrane protein, highly similar to hypothetical or other membrane proteins e.g. AL133220|SCC75A_6|T50569 probable membrane protein from Streptomyces coelicolor (265 aa), FASTA scores: opt: 642, E(): 0, (43.1% identity in 248 aa overlap); P70995 HYPOTHETICAL 24.7 KD PROTEIN from Bacillus subtilis (219 aa), FASTA scores: E(): 1.5e-12, (31.3% identity in 192 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142). Q7U267 No cell wall and cell processes Rv0359 NC_002945.3 Mycobrowser_v2 CDS 439319 439756 . - 0 Mb0367c conserved protein Mb0367c, -, len: 145 aa. Equivalent to Rv0360c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c hypothetical protein from Mycobacterium leprae (137 aa),FASTA scores: opt: 793, E(): 0, (85.4% identity in 137 aa overlap). And similar to AL049754|SCH10_25c|T36537 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity in 138 aa overlap). Q7U266 No conserved hypotheticals Rv0360c NC_002945.3 Mycobrowser_v2 CDS 439839 440666 . + 0 Mb0368 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0368, -, len: 275 aa. Equivalent to Rv0361, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable conserved membrane protein (has hydrophobic stretch from residues 132-156), equivalent to AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane protein from Mycobacterium leprae (292 aa), FASTA scores: opt: 1044, E(): 0, (58.6% identity in 292 aa overlap). Q7U265 No cell wall and cell processes Rv0361 NC_002945.3 Mycobrowser_v2 CDS 1021810 1022109 . - 0 Mb0940c PE7 pe family protein pe7 Mb0940c, PE7, len: 99 aa. Equivalent to Rv0916c,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many e.g. Rv1788 from Mycobacterium tuberculosis (99 aa), FASTA scores: opt: 321, E(): 1.3e-11, (53.5% identity in 99 aa overlap); etc. Q7U113 No PE/PPE Rv0916c NC_002945.3 Mycobrowser_v2 CDS 440888 442270 . + 0 Mb0369 mgtE POSSIBLE Mg2+ TRANSPORT TRANSMEMBRANE PROTEIN MGTE Mb0369, mgtE, len: 460 aa. Equivalent to Rv0362,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 460 aa overlap). Possible mgtE,magnesium (Mg2+) transport transmembrane protein; C-terminal region is highly similar to MGTE|G780283 putative Mg2+ transporter from Providencia stuarti (314 aa), FASTA scores: E(): 0, (47.2% identity in 307 aa overlap) (N-terminus extends approx. 150 aa further upstream compared to P. stuarti ORF). Also similar in part to others e.g. AAK20879.1|AF334760_1|AF334760 putative Mg2+ transporter from Aeromonas hydrophila (455 aa); NP_231292.1|NC_002505 magnesium transporter from Vibrio cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport protein from Mesorhizobium loti (454 aa); etc. Also similar to Rv1232c|MTV006.04c from Mycobacterium tuberculosis (435 aa). Extended hydrophobic segment spanning last 130 residues. BELONG TO THE MGTE FAMILY. Q7U264 No cell wall and cell processes Rv0362 NC_002945.3 Mycobrowser_v2 CDS 442282 443316 . - 0 Mb0370c fba PROBABLE FRUCTOSE-BISPHOSPHATE ALDOLASE FBA Mb0370c, fba, len: 344 aa. Equivalent to Rv0363c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable fba (alternate gene name: fda), fructose bisphosphate aldolase (EC 4.1.2.13), equivalent to AL023514|MLCB4_18|O69600|ALF_MYCLE FRUCTOSE-BISPHOSPHATE ALDOLASE from Mycobacterium leprae (345 aa), FASTA scores: opt: 1995, E(): 0, (87.7% identity in 342 aa overlap). Also highly similar to others. BELONGS TO CLASS II FRUCTOSE-BISPHOSPHATE ALDOLASE FAMILY. COFACTOR: ZINC. X2BEQ4,P67476 No NC_002945.3 Mycobrowser_v2 CDS 705720 705917 . - 0 Mb0626A HYPOTHETICAL PROTEIN Mb0626A, -, len:65 aa. Equivelent to a conserved protein of unknown function YP_007259328 from Mycobacterium canettii strain CIPT 140060008 (99% with 64 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb0626A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BFI6 No NC_002945.3 Mycobrowser_v2 CDS 444084 445214 . - 0 Mb0372c conserved protein Mb0372c, -, len: 376 aa. Equivalent to Rv0365c,len: 376 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 376 aa overlap). Conserved hypothetical protein, very similar to G388212|CAA35191.1, a truncated ORF immediately upstream of the Corynebacterium glutamicum fda gene encoding fructose-1,6-biphosphate aldolase (304 aa), FASTA scores: E(): 7.1e-19, (42.2% identity in 296 aa overlap). Q7U262 No conserved hypotheticals Rv0365c NC_002945.3 Mycobrowser_v2 CDS 1208743 1209009 . + 0 Mb1112 CONSERVED HYPOTHETICAL PROTEIN Mb1112, -, len: 88 aa. Equivalent to Rv1083, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 88 aa overlap). Conserved hypothetical protein, similar to U15183|MLU15183_9 hypothetical protein from Mycobacterium leprae (167 aa), FASTA scores: opt: 332, E(): 1.2e-13, (58.4% identity in 101 aa overlap). Hydrophobic domain aa 25-43. Q7U0Q0 No conserved hypotheticals Rv1083 NC_002945.3 Mycobrowser_v2 CDS 445239 445832 . - 0 Mb0373c CONSERVED HYPOTHETICAL PROTEIN Mb0373c, -, len: 197 aa. Equivalent to Rv0366c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Conserved hypothetical protein, showing weak similarity to HI1395|P44173|YD95_HAEIN HYPOTHETICAL PROTEIN from Haemophilus influenzae (140 aa), FASTA scores: opt: 152,E(): 0.0015, (27.0% identity in 126 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 Glycine radical signature. Q7U261 No conserved hypotheticals Rv0366c NC_002945.3 Mycobrowser_v2 CDS 446331 447542 . - 0 Mb0375c CONSERVED HYPOTHETICAL PROTEIN Mb0375c, -, len: 403 aa. Equivalent to Rv0368c,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 403 aa overlap). Conserved hypothetical protein, showing some similarity to AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium japonicum (422 aa),FASTA scores: opt: 341, E(): 4.3e-13, (27.4% identity in 387 aa overlap); Rv2425c|MTCY428_22 hypothetical protein from Mycobacterium tuberculosis FASTA score: (30.7% identity in 238 aa overlap). Contains PS00213 Lipocalin signature. Q7U259 No conserved hypotheticals Rv0368c NC_002945.3 Mycobrowser_v2 CDS 447548 448063 . - 0 Mb0376c POSSIBLE MEMBRANE OXIDOREDUCTASE Mb0376c, -, len: 171 aa. Equivalent to Rv0369c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Possible membrane protein oxidoreductase (EC 1.-.-.-), similar to ORF 4 of the Pseudomonas thermocarboxydovorans protein of cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from Pseudomonas thermocarboxydovorans (171 aa), FASTA scores: opt: 226, E(): 9.8e-08, (31.3% identity in 166 aa overlap). Also similar to MTV036.05, MTV036.08, MTV036.09,and MTV026.10. Q7U258 No intermediary metabolism and respiration Rv0369c NC_002945.3 Mycobrowser_v2 CDS 448164 449060 . - 0 Mb0377c POSSIBLE OXIDOREDUCTASE Mb0377c, -, len: 298 aa. Equivalent to Rv0370c,len: 298 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 298 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many hypothetical proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL gene cluster from Pseudomonas/Oligotropha carboxidovorans (295 aa), FASTA scores: opt: 851, E(): 0, (48.2% identity in 282 aa overlap); AJ224684|BJAJ4684_3 cooxS from Bradyrhizobium japonicum (302 aa), FASTA scores: opt: 881, E(): 0, (47.6% identity in 290 aa overlap). Also highly similar to MTCY428_21 from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U257 No intermediary metabolism and respiration Rv0370c NC_002945.3 Mycobrowser_v2 CDS 477413 477661 . + 0 Mb0403A Conserved protein Mb0403A, len: 82 aa. Equivalent to Rv0397A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein. X2BEX9 No conserved hypotheticals Rv0397A NC_002945.3 Mycobrowser_v2 CDS 449057 449650 . - 0 Mb0378c CONSERVED HYPOTHETICAL PROTEIN Mb0378c, -, len: 197 aa. Equivalent to Rv0371c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 247, E(): 4.5e-09, (32.3% identity in 195 aa overlap). Also weak similarity with YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE from Bacillus subtilis (197 aa), FASTA scores: opt: 217,E(): 2.5e-08, (27.0% identity in 174 aa overlap). Q7U256 No conserved hypotheticals Rv0371c NC_002945.3 Mycobrowser_v2 CDS 449647 450402 . - 0 Mb0379c CONSERVED HYPOTHETICAL PROTEIN Mb0379c, -, len: 251 aa. Equivalent to Rv0372c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Conserved hypothetical protein, showing some similarity with CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1% identity in 95 aa overlap). Also similar to upstream ORF Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap). Q7U255 No conserved hypotheticals Rv0372c NC_002945.3 Mycobrowser_v2 CDS 480808 481179 . + 0 Mb0407 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0407, -, len: 123 aa. Equivalent to Rv0401, len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 123 aa overlap). Probable conserved transmembrane protein, equivalent to AL023514|MLCB4_9 putative integral membrane protein from Mycobacterium leprae (122 aa), FASTA scores: opt: 548, E(): 4.4e-32,(66.9% identity in 121 aa overlap). Q7U229 No cell wall and cell processes Rv0401 NC_002945.3 Mycobrowser_v2 CDS 450421 452820 . - 0 Mb0380c PROBABLE CARBON MONOXYDE DEHYDROGENASE (LARGE CHAIN) Mb0380c, -, len: 799 aa. Equivalent to Rv0373c,len: 799 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 799 aa overlap). Probable carbon monoxide dehydrogenase, large chain (EC 1.2.99.2), highly similar to others e.g. AAD00363.1| U80806|CUTL carbon monoxide dehydrogenase large subunit CutL protein from Hydrogenophaga pseudoflava (803 aa); S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cut operon) from Pseudomonas thermocarboxydovorans (842 aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cluster coxMSL) from Pseudomonas/Oligotropha carboxydovorans (809 aa), FASTA scores: opt: 2484, E(): 0,(56.0% identity in 804 aa overlap); etc. Q7U254 No intermediary metabolism and respiration Rv0373c NC_002945.3 Mycobrowser_v2 CDS 452817 453296 . - 0 Mb0381c PROBABLE CARBON MONOXYDE DEHYDROGENASE (SMALL CHAIN) Mb0381c, -, len: 159 aa. Equivalent to Rv0374c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable carbon monoxide dehydrogenase, small chain (EC 1.2.99.2), highly similar to others e.g. B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA scores: opt: 662, E(): 0, (59.3% identity in 150 aa overlap); CAA12063.1|AJ224684 putative carbon monoxide dehydrogenase small subunit from Bradyrhizobium japonicum (161 aa); S49123|509390|CAA54901.1|X77931|CUTC carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (163 aa); etc. Q7U253 No intermediary metabolism and respiration Rv0374c NC_002945.3 Mycobrowser_v2 CDS 457285 457836 . - 0 Mb0387c POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE) Mb0387c, -, len: 183 aa. Equivalent to Rv0380c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Possible RNA methyltransferase (EC 2.1.1.-), equivalent to CAC32002.1|AL583925 possible RNA methyltransferase from Mycobacterium leprae (182 aa). Also some similarity with others methyltransferases e.g. P19396|TRMH_ECOLI|78514|JV0043 TRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa overlap). Also similar to Rv0881, Rv3579c, Rv1644 from Mycobacterium tuberculosis. Q7U247 No intermediary metabolism and respiration Rv0380c NC_002945.3 Mycobrowser_v2 CDS 453311 454171 . - 0 Mb0382c PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM CHAIN) Mb0382c, -, len: 286 aa. Equivalent to Rv0375c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable carbon monoxide dehydrogenase, medium chain (EC 1.2.99.2),similar to others e.g. AAD00361.1|U80806|CUTM carbon monoxide dehydrogenase middle subunit from Hydrogenophaga pseudoflava (287 aa); S49122|509389|CAA54900.1|X77931|CUTB carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (287 aa); A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (288 aa),FASTA scores: opt: 594, E(): 0, (37.5% identity in 277 aa overlap); etc. Q7U252 No intermediary metabolism and respiration Rv0375c NC_002945.3 Mycobrowser_v2 CDS 454247 455389 . - 0 Mb0383c CONSERVED HYPOTHETICAL PROTEIN Mb0383c, -, len: 380 aa. Equivalent to Rv0376c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 380 aa overlap). Conserved hypothetical protein, highly similar to T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical protein from Streptomyces coelicolor (395 aa); and AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from Arthrobacter nicotinovorans (377 aa). And similar to other conserved hypothetical proteins e.g. NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical protein from Mesorhizobium loti (245 aa). Note that C-terminus shows similarity with C-termini of CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); CAB76250.1|X82447|COXI CoxI protein from Pseudomonas/Oligotropha carboxidovorans (330 aa); and AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in 138 aa overlap). Also some partial similarity with AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3% identity in 92 aa overlap); E1184330|Z99120|YURF YURF PROTEIN from Bacillus subtilis (330 aa), FASTA scores: opt: 170, E(): 2.9e- 16, (27.5% identity in 345 aa overlap). Also similar to downstream ORF Rv0372c from Mycobacterium tuberculosis (251 aa), FASTA scores: E(): 2.1e-06, (30.7% identity in 277 aa overlap). Q7U251 No conserved hypotheticals Rv0376c NC_002945.3 Mycobrowser_v2 CDS 455438 456403 . + 0 Mb0384 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LYSR-FAMILY) Mb0384, -, len: 321 aa. Equivalent to Rv0377, len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 321 aa overlap). Probable transcription regulator, lysR family, showing similarity with many hypothetical transcriptional regulators lysR homolog e.g. P32484|YEIE_ECOLI|M89774 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli (293 aa), FASTA scores: opt: 265, E(): 4.9e-11, (28.6% identity in 266 aa overlap). Also similar to Rv2282c from Mycobacterium tuberculosis. Contains PS00044 bacterial regulatory protein lysR family signature. SEEMS TO BELONG TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q7U250 No regulatory proteins Rv0377 NC_002945.3 Mycobrowser_v2 CDS 456654 456875 . + 0 Mb0385 CONSERVED HYPOTHETICAL GLYCINE RICH PROTEIN Mb0385, -, len: 73 aa. Equivalent to Rv0378, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical gly-rich protein, showing some similarity to M. tuberculosis PE_PGRS family; also similar to MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD protein (1011 aa), FASTA scores: opt: 237, E(): 0.0032,(58.7% identity in 63 aa overlap); MTV043_25. Q7U249 No conserved hypotheticals Rv0378 NC_002945.3 Mycobrowser_v2 CDS 456994 457209 . + 0 Mb0386 secE2 POSSIBLE PROTEIN TRANSPORT PROTEIN SECE2 Mb0386, secE2, len: 71 aa. Equivalent to Rv0379,len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Possible secE2,protein transport protein, showing similarity with P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: 79, E(): 4.7. (30.3% identity in 66 aa overlap); and hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (71 aa); etc. Also highly similar to U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis protein from a patient isolate (116 aa), FASTA scores: opt: 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). Note that for Rv0379|MTV036.14, a translation initiation region different to the one in U85467|MTU85467_1 was chosen. COULD BE A PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c,SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Q7U248 No cell wall and cell processes Rv0379 NC_002945.3 Mycobrowser_v2 CDS 458858 459397 . - 0 Mb0389c pyrE PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) Mb0389c, pyrE, len: 179 aa. Equivalent to Rv0382c,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable pyrE,orotate phosphoribosyltransferase (EC 2.4.2.10),equivalent to CAC32004.1|AL583925 probable purine/pyrimidine phosphoribosyltransferase from Mycobacterium leprae (179 aa). Also highly similar to many others e.g. T36540|4753874|CAB42037.1|AL049754|SCH10.28c probable orotate phosphoribosyltransferase from Streptomyces coelicolor (182 aa); H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable orotate phosphoribosyltransferase from Methanobacterium thermoautotrophicum (180 aa), FASTA scores: opt: 389, E(): 2.7e-20, (40.7% identity in 172 aa overlap); O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 OROTATE PHOSPHORIBOSYLTRANSFERASE from Sulfolobus acidocaldarius (197 aa); etc. Note that also similar to other puridine 5'-monophosphate synthases (umpA genes; UMP synthases),generally in N-terminus that corresponds to orotate phosphoribosyltransferase activity. Contains PS00589 PTS HPR component serine phosphorylation site signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. Note that previously known as umpA. X2BEW3,P0A5U1 No NC_002945.3 Mycobrowser_v2 CDS 459478 460332 . - 0 Mb0390c POSSIBLE CONSERVED SECRETED PROTEIN Mb0390c, -, len: 284 aa. Equivalent to Rv0383c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Possible conserved secreted protein, with hydrophobic stretch in N-terminus and Pro-rich C-terminus. Equivalent to CAC32006.1|AL583925 possible secreted protein from Mycobacterium leprae (286 aa). Q7U245 No cell wall and cell processes Rv0383c NC_002945.3 Mycobrowser_v2 CDS 460473 463019 . - 0 Mb0391c clpB PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1) Mb0391c, clpB, len: 848 aa. Equivalent to Rv0384c,len: 848 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 848 aa overlap). Probable clpB (alternate gene name: htpM), endopeptidase ATP-binding protein, chain B (EC 3.-.-.-), equivalent to AC32007.1|AL583925 heat shock protein from Mycobacterium leprae (848 aa). Also highly similar to others e.g. P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB PROTEIN (heat-inducible expression) from Corynebacterium glutamicum (852 aa), FASTA scores: opt: 4113, E(): 0, (74.5% identity in 846 aa overlap); T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c probable ATP-dependent proteinase ATP-binding chain from Streptomyces coelicolor (853 aa); P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains K12 and O157:H7 (857 aa); etc. Also similar to Rv3596c|ClpC from Mycobacterium tuberculosis. Contains PS00870 and PS00871 Chaperonins clpA/B signatures and two PS000017 ATP/GTP-binding site motives A (P-loop). BELONGS TO THE CLPA/CLPB FAMILY. Contains probable coiled-coil domain from aa 411-503. X2BEW5,P63287 No NC_002945.3 Mycobrowser_v2 CDS 503186 503392 . + 0 Mb0424 thiS POSSIBLE PROTEIN THIS Mb0424, thiS, len: 68 aa. Equivalent to Rv0416,len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Possible thiS protein,equivalent to T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 hypothetical protein from Mycobacterium leprae (74 aa),FASTA scores: opt: 303, E(): 2e-18, (71.6% identity in 74 aa overlap). Shows weak similarity with O32583|THIS_ECOLI|THIG1|B3991.1 THIS PROTEIN from Escherichia coli strain K12 (66 aa), FASTA scores: opt: 103, E(): 0.052, (30.9% identity in 68 aa overlap). Q7U216 No intermediary metabolism and respiration Rv0416 NC_002945.3 Mycobrowser_v2 CDS 463152 464324 . + 0 Mb0392 PROBABLE MONOOXYGENASE Mb0392, -, len: 390 aa. Equivalent to Rv0385, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Probable monooxygenase (EC 1.-.-.-), similar to T37003|5738846|CAB52917.1|AL109949 probable flavohemoprotein from Streptomyces coelicolor (435 aa); and similar in part (C-termini) to various monooxygenases e.g. P19734|DMPP_PSESP|94993|F37831 PHENOL HYDROXYLASE P5 PROTEIN (PHENOL 2-MONOOXYGENASE P5 COMPONENT) (EC 1.14.13.7) from Pseudomonas putida (353 aa), FASTA scores: opt: 363, E(): 4.2e-16, (31.8% identity in 255 aa overlap); S47292|2120861|pir|S70085 phenol 2-monooxygenase (EC 1.14.13.7) chain mopP from Acinetobacter calcoaceticus (350 aa); P21394|XYLA_PSEPU|94933|B37316 XYLENE MONOOXYGENASE ELECTRON TRANSFER COMPONENT (EC 1.18.1.3) [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE] from Pseudomonas putida plasmid pWW0 (350 aa); AAC38360.1|AF043544|NtnMA|ntnA reductase component of 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 aa); etc. Q7U244 No intermediary metabolism and respiration Rv0385 NC_002945.3 Mycobrowser_v2 CDS 467689 469020 . - 0 Mb0394c PPE9 conserved hypothetical protein Mb0394c, PPE9, len: 443 aa. Equivalent to Rv0388c and Rv0387c, len: 180 aa and 244 aa, from Mycobacterium tuberculosis strain H37Rv, (95.1% identity in 164 aa overlap and 100.0% identity in 244 aa overlap). Rv0388c: Member of the Mycobacterium tuberculosis PPE family,highly similar to others e.g. MTCY10G2_10|Z92539 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 667, E(): 0, (58.3% identity in 180 aa overlap) but much shorter. Rv0387c: conserved hypothetical protein, showing some similarity to MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon 1, Elastin (687 aa), FASTA scores: opt: 193, E(): 0.35, (34.4% identity in 189 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (tctacagt-gctacagg), and lastly of 28 bases, leads to a longer single product. Q7U242 No PE/PPE Rv0388c NC_002945.3 Mycobrowser_v2 CDS 469354 470613 . + 0 Mb0395 purT PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) (FORMATE-DEPENDENT GAR TRANSFORMYLASE) Mb0395, purT, len: 419 aa. Equivalent to Rv0389,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 419 aa overlap). Probable purT,phosphoribosylglycinamide formyltransferase 2 (EC 2.1.2.-), similar to others e.g. P33221|PURT_ECOLI|B1849 phosphoribosylglycinamide formyltransferase 2 from Escherichia coli strain K-12 (391 aa), FASTA scores: opt: 481, E(): 1.3e-22, (40.1% identity in 379 aa overlap); etc. BELONGS TO THE PURK / PURT FAMILY. COFACTOR: MAGNESIUM. Q7U241 No intermediary metabolism and respiration Rv0389 NC_002945.3 Mycobrowser_v2 CDS 470610 471032 . + 0 Mb0396 conserved protein Mb0396, -, len: 140 aa. Equivalent to Rv0390, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein from Mycobacterium leprae (147 aa), FASTA scores: opt: 778, E(): 0, (79.0% identity in 138 aa overlap). Also similar to hypothetical proteins from several Rickettsia species. Q7U240 No conserved hypotheticals Rv0390 NC_002945.3 Mycobrowser_v2 CDS 471029 472249 . + 0 Mb0397 metZ PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ (OSH SULFHYDRYLASE) Mb0397, metZ, len: 406 aa. Equivalent to Rv0391,len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable metZ,O-succinylhomoserine sulfhydrylase (EC 4.2.99.-),equivalent, but shorter 20 aa in N-terminus, to AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from Mycobacterium leprae (426 aa). Also highly similar to others e.g. METZ_PSEAE|P55218 o-succinylhomoserine sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA scores: opt: 1175, E(): 0, (47.2% identity in 392 aa overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. Could also be a cystathionine gamma-synthase (EC 4.2.99.9). Q7U239 No intermediary metabolism and respiration Rv0391 NC_002945.3 Mycobrowser_v2 CDS 472246 473658 . - 0 Mb0398c ndhA PROBABLE MEMBRANE NADH DEHYDROGENASE NDHA Mb0398c, ndhA, len: 470 aa. Equivalent to Rv0392c,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 470 aa overlap). Probable ndhA,membrane NADH dehydrogenase (EC 1.6.99.3), equivalent to many e.g. AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium smegmatis (457 aa), FASTA scores: opt: 1991,E(): 0, (67.9% identity in 458 aa overlap); MLCB1788_3 NADH dehydrogenase from Mycobacterium leprae (466 aa),FASTA score: (62.5% identity in 467 aa overlap). Also similar to others from several organisms e.g. P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH DEHYDROGENASE from Escherichia coli (434 aa); and Rv0392c|ndhB from Mycobacterium tuberculosis. Has hydrophobic stretch in C-terminus. BELONGS TO THE NADH DEHYDROGENASE FAMILY. Q7U238 No NC_002945.3 Mycobrowser_v2 CDS 473800 475125 . + 0 Mb0399 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0399, -, len: 441. Equivalent to Rv0393, len: 441 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 441 aa overlap). Member of Mycobacterium tuberculosis 13E12 repeat family of conserved proteins,similar to many e.g. Rv1148c, Rv1945, Rv3467,Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0, (61.1% identity in 347 aa overlap). Q7U237 No insertion seqs and phages Rv0393 NC_002945.3 Mycobrowser_v2 CDS 475141 475860 . - 0 Mb0400c POSSIBLE SECRETED PROTEIN Mb0400c, -, len: 239 aa. Equivalent to Rv0394c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible secreted protein, sharing no homology with other proteins. Has hydrophobic stretch at its N-terminus. Q7U236 No cell wall and cell processes Rv0394c NC_002945.3 Mycobrowser_v2 CDS 475959 476363 . + 0 Mb0401 HYPOTHETICAL PROTEIN Mb0401, -, len: 134 aa. Equivalent to Rv0395, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Hypothetical unknown protein. Q7U235 No conserved hypotheticals Rv0395 NC_002945.3 Mycobrowser_v2 CDS 476369 476761 . + 0 Mb0402 HYPOTHETICAL PROTEIN Mb0402, -, len: 130 aa. Equivalent to Rv0396, len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Hypothetical unknown protein. Q7U234 No conserved hypotheticals Rv0396 NC_002945.3 Mycobrowser_v2 CDS 476835 477203 . + 0 Mb0403 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0403, -, len: 122 aa. Equivalent to Rv0397, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Part of 13E12 repeat family of conserved Mycobacterium tuberculosis proteins,similar to downstream Rv0393|Z84725|MTCY4D9_5 CONSERVED 13E12 REPEAT FAMILY PROTEIN (441 aa), FASTA scores: E(): 0, (87.7% identity in 122 aa overlap). Q7U233 No insertion seqs and phages Rv0397 NC_002945.3 Mycobrowser_v2 CDS 478346 479575 . - 0 Mb0405c lpqK POSSIBLE CONSERVED LIPOPROTEIN LPQK Mb0405c, lpqK, len: 409 aa. Equivalent to Rv0399c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Possible lpqK,conserved lipoprotein, showing some similarity to penicillin binding proteins and various peptidases e.g. DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase protein (406 aa), FASTA scores: opt: 348, E(): 5.6e-16,(29.2% identity in 301 aa overlap). Also similar to other Mycobacterium tuberculosis PBPs and esterases. Has possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Q7U231 No NC_002945.3 Mycobrowser_v2 CDS 479585 480772 . - 0 Mb0406c fadE7 acyl-coa dehydrogenase fade7 Mb0406c, fadE7, len: 395 aa. Equivalent to Rv0400c,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 395 aa overlap). Probable fadE7,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. CAC12923.1|AL445403 putative acyl CoA dehydrogenase from Streptomyces coelicolor (397 aa); G624219 GLUTARYL-COA DEHYDROGENASE PRECURSOR (438 aa), FASTA scores: opt: 1161,E(): 0, (48.1% identity in 391 aa overlap); etc. Q7U230 No NC_002945.3 Mycobrowser_v2 CDS 481374 482477 . - 0 Mb0408c mmpL1b PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL1B [SECOND PART] Mb0408c, mmpL1b, len: 367 aa. Equivalent to 3' end of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 367 aa overlap). Probable mmpL1, conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kd membrane protein from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0, (55.4% identity in 933aa overlap); YV34_MYCLE|P54881 hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3615,E(): 0, (55.5% identity in 941 aa overlap); etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and M. leprae e.g. Rv0450c,Rv0676c, Rv0507, etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b. Q7U228 No NC_002945.3 Mycobrowser_v2 CDS 482474 484249 . - 0 Mb0409c mmpL1a PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL1A [FIRST PART] Mb0409c, mmpL1a, len: 591 aa. Equivalent to 5' end of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 568 aa overlap). Probable mmpL1, conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kd membrane protein from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0,(55.4% identity in 933aa overlap); YV34_MYCLE|P54881 hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3615, E(): 0, (55.5% identity in 941 aa overlap); etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and M. leprae e.g. Rv0450c, Rv0676c, Rv0507,etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b. Q7U227 No NC_002945.3 Mycobrowser_v2 CDS 484246 484674 . - 0 Mb0410c mmpS1 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS1 Mb0410c, mmpS1, len: 142 aa. Equivalent to Rv0403c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable mmpS1,conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. YV33_MYCLE|P54880 hypothetical 16.9 kd protein from Mycobacterium leprae (154 aa), FASTA scores: opt: 458,E(): 1.6e-26, (46.9% identity in 143 aa overlap); YV33_MYCTU|Q11170 hypothetical 15 .9 kd protein from M. tuberculosis (147 aa), FASTA scores: opt: 362, E(): 1.1e-19, (42.1% identity in 140 aa overlap); etc. Also similar to other MmpS proteins from Mycobacterium tuberculosis e.g. Rv0677c, Rv0451c, etc. BELONGS TO THE MMPS FAMILY. X2BEY5,P0A5K1 No NC_002945.3 Mycobrowser_v2 CDS 484995 486752 . + 0 Mb0411 fadD30 fatty-acid-amp ligase fadd30 (fatty-acid-amp synthetase) (fatty-acid-amp synthase) Mb0411, fadD30, len: 585 aa. Equivalent to Rv0404,len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 585 aa overlap). Probable fadD30,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa); MASC_MYCLE|P54200 masc protein from Mycobacterium leprae (372 aa), FASTA scores: opt: 888, E(): 0, (44.2% identity in 342 aa overlap). Also similar to Y06J_MYCTU|Q10976 hypothetical 67.9 kd protein (626 aa), FASTA scores: opt: 1463, E(): 0, (42.4% identity in 568 aa overlap). X2BEY1,Q7U226 No NC_002945.3 Mycobrowser_v2 CDS 486749 488131 . + 0 Mb0412 pks6a PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6A [FIRST PART] Mb0412, pks6a, len: 460 aa. Equivalent to 5' end of Rv0405, len: 1402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 456 aa overlap). Probable pks6, membrane-bound polyketide synthase, highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa),FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g) splits pks6 into 2 parts, pks6a and pks6b. Q7U225 No NC_002945.3 Mycobrowser_v2 CDS 488118 490958 . + 0 Mb0413 pks6b PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6B [SECOND PART] Mb0413, pks6b, len: 946 aa. Equivalent to 3' end of Rv0405, len: 1402 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 945 aa overlap). Probable pks6, membrane-bound polyketide synthase, highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa),FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g), splits pks6 into 2 parts, pks6a and pks6b. Q7U224 No NC_002945.3 Mycobrowser_v2 CDS 490906 491724 . - 0 Mb0414c BETA LACTAMASE LIKE PROTEIN Mb0414c, -, len: 272 aa. Equivalent to Rv0406c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Beta-lactamase-like protein, equivalent to AAD38170.1|AF152397_1 beta-lactamase-like protein from Mycobacterium phlei (243 aa); AL023514|MLCB4_8 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1284,E(): 0, (74.9% identity in 243 aa overlap); and AAD38164.1|AF152394_2 beta-lactamase-like protein from Mycobacterium avium (247 aa), FASTA scores: opt: 1301,E(): 0, (74.2% identity in 244 aa overlap); etc. Also slight similarity to others beta-lactamases and hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349 METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa),FASTA scores: (34.4% identity in 96 aa overlap). Q7U223 No conserved hypotheticals Rv0406c NC_002945.3 Mycobrowser_v2 CDS 491802 492812 . + 0 Mb0415 fgd1 f420-dependent glucose-6-phosphate dehydrogenase fgd1 Mb0415, fgd1, len: 336 aa. Equivalent to Rv0407,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable fgd1,F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), equivalent to others from Mycobacteria e.g. AAD38165.1|AF152394_3 from M. avium (336 aa), FASTA scores: opt: 2082, E(): 0, (89.9% identity in 336 aa overlap); AL023514|MLCB 4_7 from Mycobacterium leprae (336 aa), FASTA scores: opt: 2069, E(): 0, (89.0% identity in 336 aa overlap). Also similar to other dehydrogenases e.g. CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase from Methanofollis liminatans (330 aa). Also similar to many proteins from Mycobacterium tuberculosis e.g. Rv0953c, Rv0791c, etc. Note that previously known as fgd. Q7U222 No intermediary metabolism and respiration Rv0407 NC_002945.3 Mycobrowser_v2 CDS 492805 494877 . + 0 Mb0416 pta PROBABLE PHOSPHATE ACETYLTRANSFERASE PTA (PHOSPHOTRANSACETYLASE) Mb0416, pta, len: 690 aa. Equivalent to Rv0408,len: 690 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 690 aa overlap). Probable pta,phosphate acetyltransferase (EC 2.3.1.8), highly similar to others e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 phosphate acetyltransferase from Escherichia coli strain K12 (713 aa), FASTA scores: opt: 1303, E(): 0, (38.0% identity in 718 aa overlap); etc. BELONGS TO THE PHOSPHATE ACETYLTRANSFERASE AND BUTYRYLTRANSFERASE FAMILY. Q7U221 No intermediary metabolism and respiration Rv0408 NC_002945.3 Mycobrowser_v2 CDS 494870 496027 . + 0 Mb0417 ackA PROBABLE ACETATE KINASE ACKA (ACETOKINASE) Mb0417, ackA, len: 385 aa. Equivalent to Rv0409,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Probable ackA,acetate kinase (EC 2.7.2.1), highly similar to others e.g. ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis (395 aa), FASTA scores: opt: 974, E(): 0, (43.5% identity in 393 aa overlap); etc. Contains PS01075 Acetate and butyrate kinases family signature 1, PS00758 ArgE / dapE / ACY1/ CPG2 / yscS family signature 1. BELONGS TO THE ACETOKINASE FAMILY. X2BEY2,P63410 No intermediary metabolism and respiration Rv0409 NC_002945.3 Mycobrowser_v2 CDS 521343 522473 . + 0 Mb0441 CONSERVED HYPOTHETICAL PROTEIN Mb0441, -, len: 376 aa. Equivalent to Rv0433, len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. P77213|YBDK_ECOLI hypothetical 41.7 KD protein from Escherichia coli strain K12 (372 aa), FASTA scores: opt: 555, E(): 2e-30, (28.2% identity in 365 aa overlap). X2BF10,P64694 No conserved hypotheticals Rv0433 NC_002945.3 Mycobrowser_v2 CDS 502167 503189 . + 0 Mb0423 thiO POSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO Mb0423, thiO, len: 340 aa. Equivalent to Rv0415,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). Possible thiO,thiamine biosynthesis oxidoreductase (EC 1.-.-.-),equivalent to T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical protein from Mycobacterium leprae (340 aa),FASTA scores: opt: 1867, E(): 0, (82.0% identity in 338 aa overlap). Shows some similarity to other thiO proteins e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see citation below); AAG31046.1|AF264948_8|THIO putative amino acid oxidase flavoprotein ThiO from Erwinia amylovora (349 aa); NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti (333 aa); etc. Q7U217 No intermediary metabolism and respiration Rv0415 NC_002945.3 Mycobrowser_v2 CDS 496081 498333 . - 0 Mb0418c pknG SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G) Mb0418c, pknG, len: 750 aa. Equivalent to Rv0410c,len: 750 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 750 aa overlap). pknG,serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium leprae (767 aa). Also similar to others e.g. AB76890.1|AL159139 putative serine/threonine protein kinase from Streptomyces coelicolor (774 aa); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. X2BEZ4,P65729 No NC_002945.3 Mycobrowser_v2 CDS 498333 499319 . - 0 Mb0419c glnH PROBABLE GLUTAMINE-BINDING LIPOPROTEIN GLNH (GLNBP) Mb0419c, glnH, len: 328 aa. Equivalent to Rv0411c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 328 aa overlap). Probable glnH,glutamine-binding protein, membrane-bound lipoprotein (see citation below), equivalent to AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 glutamine-binding protein homolog from Mycobacterium leprae (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3% identity in 328 aa overlap). Also similar to others e.g. GLNH_BACST|P27676 glutamine-binding protein precursor from Bacillus stearothermophilus (262 aa), FASTA scores: opt: 493, E(): 7.5e-22, (37.8% identity in 193 aa overlap); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 3. Presumed attached to the membrane by a lipid anchor. Q7U220 No NC_002945.3 Mycobrowser_v2 CDS 499319 500638 . - 0 Mb0420c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0420c, -, len: 439 aa. Equivalent to Rv0412c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Possible conserved membrane protein, equivalent to AL035159|MLCB1450_16|T44737 probable membrane protein from Mycobacterium leprae (403 aa), FASTA scores: opt: 2027,E(): 0, (80.4% identity in 403 aa overlap). Also some similarity with CAB71201.1|AL138538 putative secreted protein from Streptomyces coelicolor (429 aa). Q7U219 No cell wall and cell processes Rv0412c NC_002945.3 Mycobrowser_v2 CDS 500732 501385 . + 0 Mb0421 mutT3 POSSIBLE MUTATOR PROTEIN MUTT3 (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE) (8-OXO-DGTPASE) (DGTP PYROPHOSPHOHYDROLASE) Mb0421, mutT3, len: 217 aa. Equivalent to Rv0413,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Possible mutT3,mutator protein (EC 3.6.1.-), showing some similarity with e.g. MUTT_PROVU|P32090 mutator mutt protein from Proteus vulgaris (112 aa), FASTA scores: opt: 151, E(): 0.0008,(40.7% identity in 59 aa overlap). SEEMS TO BELONG TO THE NUDIX HYDROLASE FAMILY. Q7U218 No NC_002945.3 Mycobrowser_v2 CDS 501369 502037 . - 0 Mb0422c thiE thiamine-phosphate pyrophosphorylase thie (tmp pyrophosphorylase) (tmp-ppase) (thiamine-phosphate synthase) Mb0422c, thiE, len: 222 aa. Equivalent to Rv0414c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable thiE,thiamin phosphate pyrophosphorylase (EC 2.5.1.3),equivalent to Q9ZBL5|AL035159|MLCB1450_17 PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE from Mycobacterium leprae (235 aa), FASTA scores: opt: 1095, E(): 0, (78.0% identity in 223 aa overlap). Also similar to others e.g. T34974|5689976|CAB52013.1|AL109663 probable thiamin phosphate pyrophosphorylase from Streptomyces coelicolor (223 aa); THIE_ECOLI|P30137 thie protein from Escherichia coli strain K12 (211 aa), FASTA scores: opt: 275, E(): 7.8e-12, (37.8% identity in 196 aa overlap); etc. BELONGS TO THE TMP-PPASE FAMILY. X2BEY7,P66917 No NC_002945.3 Mycobrowser_v2 CDS 503385 504143 . + 0 Mb0425 thiG PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG (THIAZOLE BIOSYNTHESIS PROTEIN) Mb0425, thiG, len: 252 aa. Equivalent to Rv0417,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 252 aa overlap). Probable thiG, thiamin biosynthesis protein, equivalent to AL035159|MLCB1450_20|T44741|THIG probable thiamin biosynthesis protein from Mycobacterium leprae (261 aa),FASTA scores: opt: 1380, E(): 0, (86.8% identity in 250 aa overlap). Also highly similar to others e.g. SCOEDB|SC6E10.03|T35490|THIG probable thiazole biosynthesis protein from Streptomyces coelicolor (264 aa); F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG thiamin biosynthesis protein thiG from Xylella fastidiosa (275 aa); P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089.1|U00006 THIG PROTEIN thiamin biosynthesis protein from Escherichia coli strain K-12 (281 aa); etc. BELONGS TO THE THIG FAMILY. X2BF00,P59948 No intermediary metabolism and respiration Rv0417 NC_002945.3 Mycobrowser_v2 CDS 504515 506017 . + 0 Mb0426 lpqL PROBABLE LIPOPROTEIN AMINOPEPTIDASE LPQL Mb0426, lpqL, len: 500 aa. Equivalent to Rv0418,len: 500 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 500 aa overlap). Probable lpqL,lipoprotein aminopeptidase (EC 3.4.11.-), similar to others e.g. B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 probable aminopeptidase from Pseudomonas aeruginosa (536 aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase (EC 3.4.11.-) from Streptomyces griseus (284 aa) (homology only with C-terminus of Rv0418); P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y (EC 3.4.11.-) from Saccharomyces cerevisiae (537 aa); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U215 No cell wall and cell processes Rv0418 NC_002945.3 Mycobrowser_v2 CDS 506105 507601 . + 0 Mb0427 lpqM POSSIBLE LIPOPROTEIN PEPTIDASE LPQM Mb0427, lpqM, len: 498 aa. Equivalent to Rv0419,len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 498 aa overlap). Possible lpqM,lipoprotein peptidase (EC 3.4.-.-); has potential N-terminal signal peptide and contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q7U214 No cell wall and cell processes Rv0419 NC_002945.3 Mycobrowser_v2 CDS 507580 507990 . - 0 Mb0428c POSSIBLE TRANSMEMBRANE PROTEIN Mb0428c, -, len: 136 aa. Equivalent to Rv0420c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 136 aa overlap). Possible transmembrane protein; has potential transmembrane domains aa 53-99 and aa 100-122. Q7U213 No cell wall and cell processes Rv0420c NC_002945.3 Mycobrowser_v2 CDS 508151 508780 . - 0 Mb0429c CONSERVED HYPOTHETICAL PROTEIN Mb0429c, -, len: 209 aa. Equivalent to Rv0421c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Conserved hypothetical protein, showing similarity with NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical protein from Mesorhizobium loti (214 aa). Q7U212 No conserved hypotheticals Rv0421c NC_002945.3 Mycobrowser_v2 CDS 517036 517911 . - 0 Mb0435c xthA PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI) Mb0435c, xthA, len: 291 aa. Equivalent to Rv0427c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (EC 3.1.11.2), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. BELONGS TO THE AP/EXOA FAMILY OF DNA REPAIR ENZYMES. Q7U208 No NC_002945.3 Mycobrowser_v2 CDS 508777 509574 . - 0 Mb0430c thiD PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE) Mb0430c, thiD, len: 265 aa. Equivalent to Rv0422c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Probable thiD,phosphomethylpyrimidine kinase (EC 2.7.4.7), equivalent to AL035159|MLCB1450_21 PHOSPHOMETHYLPYRIMIDINE KINASE from Mycobacterium leprae (279 aa), FASTA scores: opt: 1386,E(): 0, (77.8% identity in 266 aa overlap). Also highly similar to others e.g. HIU32725_3|P44697|THID_HAEIN PHOSPHOMETHYLPYRIMIDINE KINASE from Haemophilus influenzae (269 aa), FASTA scores: opt: 605, E(): 0, (42.1% identity in 259 aa overlap). BELONGS TO THE THID FAMILY. X2BF06,P66914 No NC_002945.3 Mycobrowser_v2 CDS 617996 618646 . + 0 Mb0539 POSSIBLE THIOREDOXIN PROTEIN (THIOL-DISULFIDE INTERCHANGE PROTEIN) Mb0539, -, len: 216 aa. Equivalent to Rv0526, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Possible thioredoxin protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q49816|U2168C|S72901 hypothetical protein from Mycobacterium leprae (216 aa), FASTA scores: opt: 1144, E(): 0, (78.5% identity in 214 aa overlap). C-terminus shows some similarity to C-terminus of thioredoxins e.g. RESA_BACSU|P35160 resa protein from Bacillus subtilis (181 aa), FASTA scores: opt: 200, E(): 7.4e-06, (24.2% identity in 132 aa overlap); etc. Also similar to Mycobacterium tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194 Thioredoxin family active site. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY. Q7U1U8 No intermediary metabolism and respiration Rv0526 NC_002945.3 Mycobrowser_v2 CDS 509601 511244 . - 0 Mb0431c thiC PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC Mb0431c, thiC, len: 547 aa. Equivalent to Rv0423c,len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 547 aa overlap). Probable thiC,thiamin biosynthesis protein, equivalent to Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity in 547 aa overlap). Also highly similar to others e.g. P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E(): 0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI THIC PROTEIN from Escherichia coli strain K12 (631 aa),FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa overlap); etc. BELONGS TO THE THIC FAMILY. X2BF01,P66912 No NC_002945.3 Mycobrowser_v2 CDS 511396 511671 . - 0 Mb0432c HYPOTHETICAL PROTEIN Mb0432c, -, len: 91 aa. Equivalent to Rv0424c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Hypothetical unknown protein. Q7U211 No conserved hypotheticals Rv0424c NC_002945.3 Mycobrowser_v2 CDS 511721 516340 . - 0 Mb0433c ctpH POSSIBLE METAL CATION TRANSPORTING P-TYPE ATPASE CTPH Mb0433c, ctpH, len: 1539 aa. Equivalent to Rv0425c,len: 1539 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1539 aa overlap). Possible ctpH,metal cation-transporting P-type ATPase (transmembrane protein) (EC 3.6.1.-), showing some similarity with CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative cation-transporting ATPase from Mycobacterium leprae (1609 aa). Also similar to others ATPases e.g. AE000873_1 CATION-TRANSPORTING P-ATPASE from Methanobacterium thermoautotrop (844 aa), FASTA score: (30.5% identity in 827 aa overlap); AB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); etc. C-terminal region similar to other ATPases from Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative cation-transporting ATPase C (855 aa), FASTA scores: opt: 770, E(): 5.3e-32, (44.9% identity in 820 aa overlap). Q7U210 No NC_002945.3 Mycobrowser_v2 CDS 516392 516835 . - 0 Mb0434c POSSIBLE TRANSMEMBRANE PROTEIN Mb0434c, -, len: 147 aa. Equivalent to Rv0426c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Possible transmembrane protein; has potential transmembrane domains aa 19-41, and aa 61-83. Q7U209 No cell wall and cell processes Rv0426c NC_002945.3 Mycobrowser_v2 CDS 517914 518822 . - 0 Mb0436c gcn5-related n-acetyltransferase Mb0436c, -, len: 302 aa. Equivalent to Rv0428c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Hypothetical unknown protein. Q7U207 No intermediary metabolism and respiration Rv0428c NC_002945.3 Mycobrowser_v2 CDS 518822 519415 . - 0 Mb0437c def PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Mb0437c, def, len: 197 aa. Equivalent to Rv0429c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Probable def,polypeptide deformylase (EC 3.5.1.31), equivalent to CAC30884.1|AL583923 polypeptide deformylase from Mycobacterium leprae (197 aa). Also similar to others e.g. DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from Escherichia coli (169 aa), FASTA scores: opt: 179, E(): 1.8e-05, (34.6% identity in 162 aa overlap); etc. BELONGS TO THE POLYPEPTIDE DEFORMYLASE FAMILY. COFACTOR: BINDS 1 ZINC ION. X2BF02,Q7U206 No NC_002945.3 Mycobrowser_v2 CDS 519752 520060 . + 0 Mb0438 CONSERVED HYPOTHETICAL PROTEIN Mb0438, -, len: 102 aa. Equivalent to Rv0430, len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, equivalent to AC30882.1|AL583923 conserved hypothetical protein from Mycobacterium leprae (102 aa). Also highly similar to CAB93047.1|SCD95A.20|AL357432 hypothetical protein from Streptomyces coelicolor (84 aa). Q7U205 No conserved hypotheticals Rv0430 NC_002945.3 Mycobrowser_v2 CDS 520092 520586 . + 0 Mb0439 PUTATIVE TUBERCULIN RELATED PEPTIDE Mb0439, -, len: 164 aa. Equivalent to Rv0431, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 164 aa overlap). Putative tuberculin related peptide; almost identical to D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis (172 aa), FASTA score: (99.4% identity in 163 aa overlap). Highly similar to to CAC30881.1|AL583923 tuberculin related peptide (AT103) from Mycobacterium leprae (167 aa). Some similarity to G550415|HRPC (282 aa), FASTA scores: opt: 120, E(): 0.36, (33.3% identity in 111 aa overlap). Potential transmembrane domain at aa 19-37. Q7U204 No cell wall and cell processes Rv0431 NC_002945.3 Mycobrowser_v2 CDS 520619 521341 . + 0 Mb0440 sodC periplasmic superoxide dismutase [cu-zn] sodc Mb0440, sodC, len: 240 aa. Equivalent to Rv0432,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable sodC,periplasmic superoxide dismutase [Cu-Zn] (EC 1.15.1.1),equivalent to CAC30880.1|AL583923 superoxide dismutase precursor (Cu-Zn) from Mycobacterium leprae (240 aa); and AAK20038.1|AF326234_1 copper zinc superoxide dismutase from Mycobacterium avium subsp. paratuberculosis (226 aa). Also similar to others e.g. SODC_PHOLE|P00446 superoxide dismutase precursor (cu-zn) from Photobacterium leiognathi (173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5% identity in 181 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. BELONGS TO THE CU-ZN SUPEROXIDE DISMUTASE FAMILY. Possibly localized in periplasm, membrane-bound. X2BF16,P0A609 No virulence, detoxification, adaptation Rv0432 NC_002945.3 Mycobrowser_v2 CDS 623479 623796 . + 0 Mb0544 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0544, -, len: 105 aa. Equivalent to Rv0531, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Possible conserved membrane protein, highly similar to Y13803|MLB1306_1|CAA74131.1 hypothetical protein from Mycobacterium leprae (86 aa), FASTA scores: E(): 2.1e-24,(74.4% identity in 86 aa overlap); and NP_302557.1|NC_002677 putative membrane protein from Mycobacterium leprae (111 aa). Q7U1U3 No cell wall and cell processes Rv0531 NC_002945.3 Mycobrowser_v2 CDS 533415 533930 . + 0 Mb0451 conserved protein Mb0451, -, len: 171 aa. Equivalent to Rv0443, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Conserved hypothetical protein, highly similar to AL049863|SC5H1_23|T35339 hypothetical protein from Streptomyces coelicolor (171 aa), FASTA scores: opt: 561,E(): 2.3e-32, (49.7% identity in 165 aa overlap); and CAC42482.1|AJ318385 hypothetical protein from Amycolatopsis mediterranei (163 aa). Q7U1Z8 No conserved hypotheticals Rv0443 NC_002945.3 Mycobrowser_v2 CDS 522533 523186 . + 0 Mb0442 CONSERVED HYPOTHETICAL PROTEIN Mb0442, -, len: 217 aa. Equivalent to Rv0434, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Conserved hypothetical protein, similar to AE002052_2 from Deinococcus radiodurans (213 aa), FASTA scores: opt: 258, E(): 4e-10,(31.9% identity in 213 aa overlap); SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from Synechocystis (214 aa),FASTA scores: opt: 156, E(): 0.00041, (28.4% identity in 204 aa overlap); MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2 from Myxococcus xanthus (826 aa), FASTA scores: opt: 160, E(): 0.00068, (28.4% identity in 197 aa overlap); etc. Q7U203 No conserved hypotheticals Rv0434 NC_002945.3 Mycobrowser_v2 CDS 1243004 1243327 . + 0 Mb1148 conserved protein Mb1148, -, len: 107 aa. Equivalent to Rv1117, len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 107 aa overlap). Conserved hypothetical protein, some similarity to P94425|D50453 hypothetical protein from Bacillus subtilis (95 aa), fasta scores: opt: 128, E(): 5.1e-06, (28.3% identity in 92 aa overlap); and AL117322|SCF1.02 Streptomyces coelicolor (109 aa), FASTA scores: opt: 437, E(): 1.6e-25, (57.5% identity in 106 aa overlap). Q7U0M0 No conserved hypotheticals Rv1117 NC_002945.3 Mycobrowser_v2 CDS 523366 525552 . - 0 Mb0443c PUTATIVE CONSERVED ATPASE Mb0443c, -, len: 728 aa. Equivalent to Rv0435c,len: 728 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 728 aa overlap). Putative conserved ATPase (EC 3.6.1.-), similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, E(): 0, (34.5% identity in 693 aa overlap); NP_148637.1|7435761|B72479 transitional endoplasmic reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also similar to Rv3610c and Rv2115c from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature. Q7U202 No cell wall and cell processes Rv0435c NC_002945.3 Mycobrowser_v2 CDS 525549 526409 . - 0 Mb0444c pssA PROBABLE CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE PSSA (PS SYNTHASE) (PHOSPHATIDYLSERINE SYNTHASE) Mb0444c, pssA, len: 286 aa. Equivalent to Rv0436c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Probable pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (EC 2.7.8.8) (see citation below), integral membrane protein, equivalent to AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in 285 aa overlap). Also highly similar to others e.g. NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine synthase from Mesorhizobium loti (248 aa); PSS_BACSU|P39823 cdp-diacylglycerol--serine o-phosphatidyltransferase from Bacillus subtilis (177 aa),FASTA scores: opt: 277, E(): 9.9e-12, (33.3% identity in 183 aa overlap); etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. X2BEX8,P59949 No NC_002945.3 Mycobrowser_v2 CDS 526406 527101 . - 0 Mb0445c psd POSSIBLE PHOSPHATIDYLSERINE DECARBOXYLASE PSD (PS DECARBOXYLASE) Mb0445c, psd, len: 231 aa. Equivalent to Rv0437c,len: 231 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 231 aa overlap). Possible psd, phosphatidylserine decarboxylase (EC 4.1.1.65), equivalent to CAC29819.1|AL583918 conserved hypothetical protein from Mycobacterium leprae (243 aa); and highly similar to MLCB1450.11|T44729|4154044|CAA22695.1|AL035159 hypothetical protein from Mycobacterium leprae (202 aa),FASTA score: (74.6% identity in 197 aa overlap). Also similar to other phosphatidylserine decarboxylases e.g. NP_108058.1|14027249|BAB54203.1|AP003012 phosphatidylserine decarboxylase from Mesorhizobium loti (232 aa); AAK86872|g15156090|AGR_C_1963 phosphatidylserine decarboxylase from Agrobacterium tumefaciens (244 aa); AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase from Chlorobium tepidum (216 aa); etc. X2BF21,P67548 No NC_002945.3 Mycobrowser_v2 CDS 534110 534808 . - 0 Mb0452c rska anti-sigma factor rska (regulator of sigma k) Mb0452c, -, len: 232 aa. Equivalent to Rv0444c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 232 aa overlap). Conserved hypothetical protein; C-terminus similar to P12752|Y24K_STRGR HYPOTHETICAL 24.7 KD PROTEIN from Streptomyces griseus (238 aa), FASTA scores: opt: 207, E(): 2.2e-05, (32.9% identity in 158 aa overlap). X2BF17,Q7U1Z7 No information pathways Rv0444c NC_002945.3 Mycobrowser_v2 CDS 527162 528379 . - 0 Mb0446c moeA2 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA2 Mb0446c, moeA2, len: 405 aa. Equivalent to Rv0438c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 405 aa overlap). Probable moeA2,molybdenum cofactor biosynthesis protein, highly similar to many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 aa), FASTA scores: opt: 786, E(): 0, (39.2% identity in 398 aa overlap); etc. Also similar to MOEA1|Rv0994|MTCI237.08|O05577 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (426 aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity in 425 aa overlap). Note that previously known as moeA3. Q7U201 No NC_002945.3 Mycobrowser_v2 CDS 528398 529333 . - 0 Mb0447c probable dehydrogenase/reductase Mb0447c, -, len: 311 aa. Equivalent to Rv0439c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Probable dehydrogenase/reductase (EC 1.-.-.-), equivalent to AL035159|MLCB1450_6|T44727 probable oxidoreductase from Mycobacterium leprae (304 aa), FASTA scores: opt: 1360,E(): 0, (69.2% identity in 302 aa overlap). Also highly similar to various oxidoreductases, generally dehydrogenases/reductases e.g. PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 probable short chain dehydrogenase from Pseudomonas aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE OXIDOREDUCTASE from Streptomyces antibioticus (298 aa),FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in 298 aa overlap); etc. Q7U200 No intermediary metabolism and respiration Rv0439c NC_002945.3 Mycobrowser_v2 CDS 529627 531249 . + 0 Mb0448 groEL2 60 KDA CHAPERONIN 2 GROEL2 (PROTEIN CPN60-2) (GROEL PROTEIN 2) (65 KDA ANTIGEN) (HEAT SHOCK PROTEIN 65) (CELL WALL PROTEIN A) (ANTIGEN A) Mb0448, groEL2, len: 540 aa. Equivalent to Rv0440,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). groEL2 (alternate gene names: groL2, groEL-2, hsp65, hsp60), 60 kDa chaperonin 2 (see first citation below). PURIFIED 65 kDa ANTIGEN CAN ELICIT A STRONG DELAYED-TYPE HYPERSENSITIVITY REACTION IN EXPERIMENTAL ANIMALS INFECTED WITH M. TUBERCULOSIS. THIS PROTEIN IS ONE OF THE MAJOR IMMUNOREACTIVE PROTEINS OF THE MYCOBACTERIA. THIS ANTIGEN CONTAINS EPITOPES THAT ARE COMMON TO VARIOUS SPECIES OF MYCOBACTERIA. Contains PS00296 Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY. X2BF25,P0A521 No NC_002945.3 Mycobrowser_v2 CDS 531315 531743 . - 0 Mb0449c HYPOTHETICAL PROTEIN Mb0449c, -, len: 142 aa. Equivalent to Rv0441c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Hypothetical unknown protein. X2BEY3,P0A5C8 No conserved hypotheticals Rv0441c NC_002945.3 Mycobrowser_v2 CDS 531770 533209 . - 0 Mb0450c PPE10 ppe family protein ppe10 Mb0450c, PPE10, len: 479 aa. Equivalent to Rv0442c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 479 aa overlap). Member of the Mycobacterium tuberculosis PPE family, nearly identical to hypothetical protein from Mycobacterium tuberculosis (strain Erdman) and to AN5S46909_1 protein fragment from Mycobacterium bovis (302 aa); P42611|YHS6_MYCTU HYPOTHETICAL 50.6 KD PROTEIN (517 aa), FASTA scores: opt: 3144, E(): 0, (98.4 identity in 492 aa overlap); and S46909|S46909_1 (302 aa), FASTA scores: opt: 1897, E(): 0,(98.0% identity in 302 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 5' start due to a single base transition (g-a), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Q7U1Z9 No NC_002945.3 Mycobrowser_v2 CDS 534852 535415 . - 0 Mb0453c sigK alternative rna polymerase sigma factor sigk Mb0453c, sigK, len: 187 aa. Equivalent to Rv0445c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable sigK,alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. 5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase sigma factor from Streptomyces coelicolor (185 aa); NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase sigma factor from Mesorhizobium loti (179 aa); 1654108|AAB17906.1|U11283|A58883 probable transcription initiation factor sigma E from Rhodobacter phaeroides (168 aa), FASTA scores: opt: 299, E(): 2e-14, (32.7% identity in 168 aa overlap); Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FACTOR SIGW from Bacillus subtilis (187 aa), FASTA scores: opt: 213, E(): 2.9e-08, (26.8% identity in 179 aa overlap); etc. X2BF30,Q7U1Z6 No NC_002945.3 Mycobrowser_v2 CDS 535464 536234 . - 0 Mb0454c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0454c, -, len: 256 aa. Equivalent to Rv0446c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible conserved transmembrane protein, similar at N-terminus to U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3 from Streptomyces coelicolor (226 aa), FASTA scores: opt: 207, E(): 9.8e-07, (34.2% identity in 114 aa overlap). Also similar to others hypothetical proteins e.g. AAK04680.1|AE006291_14|AE006291) HYPOTHETICAL PROTEIN from Lactococcus lactis subsp. lactis (257 aa). Q7U1Z5 No cell wall and cell processes Rv0446c NC_002945.3 Mycobrowser_v2 CDS 636817 637119 . - 0 Mb0557c conserved protein Mb0557c, -, len: 100 aa. Equivalent to Rv0543c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Conserved hypothetical protein, equivalent to Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 493, E(): 6.1e-30, (73.5% identity in 98 aa overlap). Some similarity to Rv3046c|NP_217562.1 from Mycobacterium tuberculosis. Q7U1T4 No conserved hypotheticals Rv0543c NC_002945.3 Mycobrowser_v2 CDS 536243 537526 . - 0 Mb0455c ufaA1 probable cyclopropane-fatty-acyl-phospholipid synthase ufaa1 (cyclopropane fatty acid synthase) (cfa synthase) Mb0455c, ufaA1, len: 427 aa. Equivalent to Rv0447c,len: 427 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 427 aa overlap). Probable ufaA1,cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79), similar to others e.g. NP_102178.1|14021351|BAB47964.1|AP002994 cyclopropane-fatty-acyl-phospholipid synthase from Mesorhizobium loti (378 aa); B82240|9655593|AAF94281.1|AE004192 cyclopropane-fatty-acyl-phospholipid synthase from Vibrio cholerae (432 aa); P30010|CFA_ECOLI CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3 LPD-3 from P.putida (394 aa), FASTA scores: opt: 556, E(): 2.8e-30, (33.3% identity in 387 aa overlap); AE0005|HPAE000557_9 from Helicobacter pylori (389 aa),FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity in 382 aa overlap). Q7U1Z4 No NC_002945.3 Mycobrowser_v2 CDS 537523 538188 . - 0 Mb0456c CONSERVED HYPOTHETICAL PROTEIN Mb0456c, -, len: 221 aa. Equivalent to Rv0448c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa),FASTA scores: opt: 257, E(): 1.4e-10, (32.0% identity in 197 aa overlap); etc. Some similarity to U15183|MLU15183_38 from Mycobacterium leprae (82 aa),FASTA scores: opt: 134, E(): 0.014, (71.0% identity in 31 aa overlap). Q7U1Z3 No conserved hypotheticals Rv0448c NC_002945.3 Mycobrowser_v2 CDS 555035 555328 . + 0 Mb0472 PROBABLE CONSERVED MEMBRANE PROTEIN Mb0472, -, len: 97 aa. Equivalent to Rv0463, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Probable conserved transmembrane protein, highly similar to AAA63017.1|U15183 hypothetical protein from Mycobacterium leprae (101 aa),FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in 95 aa overlap). Q7U1Y0 No cell wall and cell processes Rv0463 NC_002945.3 Mycobrowser_v2 CDS 1243342 1244202 . - 0 Mb1149c conserved protein Mb1149c, -, len: 286 aa. Equivalent to Rv1118c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 286 aa overlap). Conserved hypothetical protein, similar to pseudogene ML0942 in Mycobacterium leprae. Q7TVC0 No conserved hypotheticals Rv1118c NC_002945.3 Mycobrowser_v2 CDS 538248 539567 . - 0 Mb0457c CONSERVED HYPOTHETICAL PROTEIN Mb0457c, -, len: 439 aa. Equivalent to Rv0449c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 439 aa overlap). Conserved hypothetical protein, some similarity with several hypothetical proteins and various enzymes e.g. AAK24569.1|AE005927 amine oxidase, flavin-containing from Caulobacter crescentus (454 aa); BAB02771.1|AB023036 mycolic acid methyl transferase-like protein from Arabidopsis thaliana (842 aa); BAB01742.1|AP000374 protein which contains similarity to cyclopropane fatty acid synthase from Arabidopsis thaliana (793 aa); etc. Has hydrophobic stretch at N-terminus. Q7U1Z2 No conserved hypotheticals Rv0449c NC_002945.3 Mycobrowser_v2 CDS 539607 542510 . - 0 Mb0458c mmpL4 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL4 Mb0458c, mmpL4, len: 967 aa. Equivalent to Rv0450c,len: 967 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 967 aa overlap). Probable mmpL4,conserved transmembrane transport protein (see citations below), member of RND superfamily, equivalent to U1740V|P54881|YV34_MYCLE HYPOTHETICAL 105.2 kDa PROTEIN from Mycobacterium leprae (959 aa), FASTA scores: opt: 5051, E(): 0, (78.4% identity in 962 aa overlap). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores: opt: 3917, E(): 0, (61.3% identity in 950 aa overlap),MTCY20G9.34, etc. Contains PS00211 ABC transporters family signature. BELONGS TO THE MMPL FAMILY. TBparse score is 0.948. Q7U1Z1 No NC_002945.3 Mycobrowser_v2 CDS 542507 542929 . - 0 Mb0459c mmpS4 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4 Mb0459c, mmpS4, len: 140 aa. Equivalent to Rv0451c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable mmpS4,conserved membrane protein (see citations below),equivalent to U1740W|P54880|YV33_MYCLE HYPOTHETICAL 16.9 kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 727, E(): 0, (75.9% identity in 137 aa overlap). Also similar to other Mycobacterial proteins e.g. Z84725|MTCY04D9.16c from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0% identity in 138 aa overlap); etc. BELONGS TO THE MMPS FAMILY. TBparse score is 0.953. X2BEZ3,P0A5K3 No NC_002945.3 Mycobrowser_v2 CDS 543161 543871 . + 0 Mb0460 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0460, -, len: 236 aa. Equivalent to Rv0452, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Possible transcriptional regulator, similar to several putative TetR-family transcriptional regulators from Streptomyces coelicolor. Also similar in N-terminus to U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 aa), FASTA score: (76.1% identity in 67 aa overlap). Contains probable helix-turn-helix motif at aa 44-65 (Score 1727, +5.07 SD). Q7U1Z0 No regulatory proteins Rv0452 NC_002945.3 Mycobrowser_v2 CDS 1895926 1896150 . + 0 Mb1710A CONSERVED HYPOTHETICAL PROTEIN Mb1710A, -, len: 74 aa. Equivalent to Rv1684, len: 74 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 74 aa overlap). Conserved hypothetical protein, similar to P75844|YCAR_ECOLI Protein YCAR from Escherichia coli (60 aa), FASTA scores: opt: 108, E(): 0.00022, (39.0% identity in 59 aa overlap). Q7TZS8 No conserved hypotheticals Rv1684 NC_002945.3 Mycobrowser_v2 CDS 544193 545749 . + 0 Mb0461 PPE11 ppe family protein ppe11 Mb0461, PPE11, len: 518 aa. Equivalent to Rv0453,len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 518 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 882, E(): 7e-31, (41.8% identity in 514 aa overlap). Q7U1Y9 No NC_002945.3 Mycobrowser_v2 CDS 545854 546204 . + 0 Mb0462 CONSERVED HYPOTHETICAL PROTEIN Mb0462, -, len: 116 aa. Equivalent to Rv0454, len: 116 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 116 aa overlap). Conserved hypothetical protein, showing similarity with AAA63007.1|U15183 hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 151, E(): 0.0019,(31.5% identity in 89 aa overlap). Q7U1Y8 No conserved hypotheticals Rv0454 NC_002945.3 Mycobrowser_v2 CDS 546394 546840 . - 0 Mb0463c conserved protein Mb0463c, -, len: 148 aa. Equivalent to Rv0455c,len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Conserved hypothetical protein, equivalent to CAC31896.1|AL583925 possible secreted protein from Mycobacterium leprae (153 aa). Has hydrophobic stretch at N-terminus. Q7U1Y7 No conserved hypotheticals Rv0455c NC_002945.3 Mycobrowser_v2 CDS 546908 547822 . - 0 Mb0464c echA2 ENOYL-COA HYDRATASE ECHA2 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0464c, echA2, len: 304 aa. Equivalent to Rv0456c,len 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Probable echA2,enoyl-CoA hydratase (EC 4.2.1.17), similar to other enoyl-coA hydratases e.g. Q13011 PEROXISOMAL ENOYL-COA HYDRATASE-LIKE PROTEIN (328 aa), FASTA scores: opt: 209,E(): 5.3e-07, (31.7% identity in 142 aa overlap). Also similar to several other proteins from Mycobacterium tuberculosis e.g. MTCY09F9.29 FASTA score: (32.9% identity in 146 aa overlap); and MTI376.01c. Q7U1Y6 No NC_002945.3 Mycobrowser_v2 CDS 548095 548376 . - 0 Mb0465c mazf1 possible toxin mazf1 Mb0465c, -, len: 93 aa. Equivalent to Rv0456A, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein; N-terminus highly similar to N-terminal part of P71650|Rv2801c|MT2869|MTCY16B7.42 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (118 aa), FASTA scores: opt: 303, E(): 1e-14, (60.44% identity in 91 aa overlap). Also some similarity in part with other hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid maintenance protein from Xylella fastidiosa (108 aa),FASTA scores: opt: 169, E(): 3.9e-05, (50.820% identity in 61 aa overlap). Q7U1Y5 No virulence, detoxification, adaptation Rv0456A NC_002945.3 Mycobrowser_v2 CDS 548363 548488 . - 0 Mb0466A mazE1 Possible antitoxin MazE1 Mb0466A, len: 41 aa. Equivalent to Rv0456B len: 57 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 40 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazE1,antitoxin, part of toxin-antitoxin (TA) operon with Rv0456A (See Pandey and Gerdes, 2005; Zhu et al., 2006). X2BF33 No virulence, detoxification, adaptation Rv0456B NC_002945.3 Mycobrowser_v2 CDS 548605 550635 . - 0 Mb0466c PROBABLE PEPTIDASE Mb0466c, -, len: 676 aa. Equivalent to Rv0457c,len: 673 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 673 aa overlap). Probable peptidase (EC 3.4.-.-), similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable peptidase (EC 3.4.21.-) (726 aa), FASTA scores: opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8% identity in 299 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa). Q7U1Y4 No intermediary metabolism and respiration Rv0457c NC_002945.3 Mycobrowser_v2 CDS 550694 552217 . + 0 Mb0467 PROBABLE ALDEHYDE DEHYDROGENASE Mb0467, -, len: 507 aa. Equivalent to Rv0458, len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 507 aa overlap). Probable aldehyde dehydrogenase (EC 1.2.1.3), highly similar to many,closest to P46369|THCA_RHOER EPTC-INDUCIBLE ALDEHYDE DEHYDROGENASE from Rhodococcus erythropolis (506 aa),FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa),FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO PROBABLE ALDEHYDE DEHYDROGENASE from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in M. tuberculosis e.g. Rv0768, Rv2858c. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. X2BF41,P63938 No intermediary metabolism and respiration Rv0458 NC_002945.3 Mycobrowser_v2 CDS 552217 552708 . + 0 Mb0468 CONSERVED HYPOTHETICAL PROTEIN Mb0468, -, len: 163 aa. Equivalent to Rv0459, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins. Note that highly similar to products of unidentified orfs in Xanthobacter autotrophicus,AF029733_2 (139 aa), and Rhodococcus erythropolis, REREUTP BC_1 (186 aa). Like MTV038.03, these ORF's are linked to aldehyde dehydrogenase genes. FASTA scores: AF0297|AF029733_2 (139 aa), opt: 439, E(): 6.2e-24, (50.0% identity in 126 aa overlap); and L24492|REREUTPBC_1 (186 aa), opt: 347, E(): 2.1e-17, (52.7% identity in 169 aa overlap). N-terminus also highly similar to AAA63041.1|U15183 ethanolamine permease (eutP) match from Mycobacterium leprae (53 aa). Q7U1Y3 No conserved hypotheticals Rv0459 NC_002945.3 Mycobrowser_v2 CDS 552768 553007 . + 0 Mb0469 CONSERVED HYDROPHOBIC PROTEIN Mb0469, -, len: 79 aa. Equivalent to Rv0460, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 79 aa overlap). Conserved hydrophobic protein, highly similar AAA63024.1|U15183 hypothetical protein from Mycobacterium leprae (56 aa), FASTA scores: opt: 197, E(): 3.7e-09, (63.8% identity in 47 aa overlap). Q7U1Y2 No conserved hypotheticals Rv0460 NC_002945.3 Mycobrowser_v2 CDS 553045 553569 . + 0 Mb0470 PROBABLE TRANSMEMBRANE PROTEIN Mb0470, -, len: 174 aa. Equivalent to Rv0461, len: 174 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 174 aa overlap). Probable transmembrane protein. Q7U1Y1 No cell wall and cell processes Rv0461 NC_002945.3 Mycobrowser_v2 CDS 641576 641884 . - 0 Mb0564c vapc3 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb0564c, -, len: 102 aa. Similar to 5' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 92 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065,and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c. Q7U1S9 No NC_002945.3 Mycobrowser_v2 CDS 553633 555027 . + 0 Mb0471 lpd dihydrolipoamide dehydrogenase lpdc (lipoamide reductase (nadh)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase) Mb0471, lpd, len: 464 aa. Equivalent to Rv0462,len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 464 aa overlap). lpd (alternate gene name: TB49.2), dihydrolipoamide dehydrogenase (EC 1.8.1.4) (see first citation below), equivalent to AAA63016.1|U15183 lipoamide dehydrogenase from Mycobacterium leprae (467 aa), FASTA scores: opt: 2583,E(): 0, (83.1% identity in 467 aa overlap). Also similar to to many e.g. P50970|DLDH_ZYMMO|X82291|ZMLPD_1 DIHYDROLIPOAMIDE DEHYDROGENASE from Z.mobilis (466 aa),FASTA scores: opt: 1198, E(): 0, (42.4 % identity in 465 aa overlap); etc. BELONG TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. X2BF35,P66005 No intermediary metabolism and respiration Rv0462 NC_002945.3 Mycobrowser_v2 CDS 555332 555904 . - 0 Mb0473c conserved protein Mb0473c, -, len: 190 aa. Equivalent to Rv0464c,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 190 aa overlap). Conserved hypothetical protein, highly similar to CAC31982.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (188 aa). Also some similarity with Rv1531|AL022000|MTV045_5|D70820 hypothetical protein from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 9.6e-10, (30.9% identity in 175 aa overlap). Q7U1X9 No conserved hypotheticals Rv0464c NC_002945.3 Mycobrowser_v2 CDS 555901 557325 . - 0 Mb0474c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0474c, -, len: 474 aa. Equivalent to Rv0465c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 474 aa overlap). Probable transcriptional regulator, highly similar to AC44331.1|AL596102 putative DNA-binding protein from Streptomyces coelicolor (489 aa); and similar to several hypothetical proteins and others transcriptional regulators. Some similarity in N-terminal region (1-100 aa) with repressors e.g. P06153|RPC_BPPH1 IMMUNITY REPRESSOR PROTEIN (144 aa), FASTA scores: opt: 130, E(): 0.084,(27.0% identity in 100 aa overlap). Very similar to Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium tuberculosis (486 aa), FASTA scores: opt: 1475, E(): 0,(47.4% identity in 468 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (1827, +5.41 SD). Q7U1X8 No regulatory proteins Rv0465c NC_002945.3 Mycobrowser_v2 CDS 557477 558271 . + 0 Mb0475 conserved protein Mb0475, -, len: 264 aa. Equivalent to Rv0466, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Conserved hypothetical protein, equivalent to CAC31980.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (264 aa). Similar to Rv2001|Z74025|MTCY39.17c HYPOTHETICAL 28.7 KDA PROTEIN from Mycobacterium tuberculosis (250 aa),FASTA scores: opt: 592, E(): 0, (38.0% identity in 263 aa overlap). Some similarity to several THIOESTERASES e.g. Q42561|ATACPTE17_1 ACYL-(ACYL CARRIER PROTEIN) THIOESTER from A. thaliana (362 aa), FASTA scores: E(): 0.0092,(24.4% identity in 197 aa overlap). Q7U1X7 No conserved hypotheticals Rv0466 NC_002945.3 Mycobrowser_v2 CDS 558546 559832 . + 0 Mb0476 icl ISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE) Mb0476, icl, len: 428 aa. Equivalent to Rv0467,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). icl (previously known as aceA), isocitrate lyase (EC 4.1.3.1) (see citations below), highly similar to many, closest to Z29367|RFISCILY_1 from R. fascians (429 aa), FASTA scores: opt: 2359, E(): 0, (80.7% identity in 429 aa overlap). BELONGS TO THE ISOCITRATE LYASE FAMILY. X2BF40,P0A5H4 No intermediary metabolism and respiration Rv0467 NC_002945.3 Mycobrowser_v2 CDS 559914 560774 . + 0 Mb0477 fadB2 3-hydroxybutyryl-coa dehydrogenase fadb2 (beta-hydroxybutyryl-coa dehydrogenase) (bhbd) Mb0477, fadB2, len: 286 aa. Equivalent to Rv0468,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable fadB2,3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157),equivalent to CAC31978.1|AL583925 3-hydroxyacyl-CoA dehydrogenase from Mycobacterium leprae (287 aa). Also similar to many 3-hydroxybutyryl-CoA dehydrogenases e.g. U32229|BJU32229_1 beta-hydroxybutyryl coenzyme A dehydrogenase from Bradyrhizobium japonicum (293 aa),FASTA scores: opt: 771, E(): 0, (45.7% identity in 282 aa overlap). BELONGS TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY. Q7U1X6 No NC_002945.3 Mycobrowser_v2 CDS 560907 561767 . + 0 Mb0478 umaA1 possible mycolic acid synthase umaa Mb0478, umaA1, len: 286 aa. Equivalent to Rv0469,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible umaA1,mycolic acid synthase (EC 2.-.-.-), highly similar to CAC30854.1|AL583923 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa),FASTA scores: opt: 1402, E(): 0, (69.6% identity in 286 aa overlap). Also very similar to mycobacterial methyltransferases e.g. U77466|CmaD|MBU77466_1 (286 aa); MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar to CFA1_MYCTU|Q11195|U66108|MTU66108_1 cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa),FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa overlap) (see citation below); and very similar also to methoxy mycolic acid synthase 1 from Mycobacterium tuberculosis e.g. MTU66108_1 (286 aa). Q7U1X5 No NC_002945.3 Mycobrowser_v2 CDS 561867 562730 . - 0 Mb0479c pcaA MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) Mb0479c, pcaA, len: 287 aa. Equivalent to Rv0470c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). pcaA (previously known as umaA2), mycolic acid synthase (cyclopropane synthase) (EC 2.-.-.-) (see citations below), equivalent to CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa); and highly similar to S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical protein from Mycobacterium leprae (308 aa); Q11195|CFA1_MYCTU CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) (287 aa) (see second citation below); U27357|MTU27357_1 cyclopropane mycolic acid synthase from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 1415, E(): 0,(72.8% identity in 287 aa overlap); and related enzymes e.g. MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA scores: opt: 1387, E(): 0, (72.5% identity in 287 aa overlap). Q7U1X4 No NC_002945.3 Mycobrowser_v2 CDS 562873 563313 . - 0 Mb0480c HYPOTHETICAL PROTEIN Mb0480c, -, len: 146 aa. Equivalent to Rv0470A,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein, could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in Mycobacterium bovis and CDC1551. Weak hits to Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: 132, E(): 1.1, (39.35% identity in 61 aa overlap). Q7U1X3 No conserved hypotheticals Rv0470A NC_002945.3 Mycobrowser_v2 CDS 563244 563732 . - 0 Mb0481c HYPOTHETICAL PROTEIN Mb0481c, -, len: 162 aa. Equivalent to Rv0471c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Hypothetical unknown protein. Q7U1X2 No conserved hypotheticals Rv0471c NC_002945.3 Mycobrowser_v2 CDS 563742 564446 . - 0 Mb0482c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0482c, -, len: 234 aa. Equivalent to Rv0472c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable regulatory protein, possibly tetR family, equivalent to CAC31974.1|AL583925 possible TetR-family transcriptional regulator from Mycobacterium leprae (233 aa). Also similar to CAC01492.1|AL391017 putative transcriptional regulatory protein from Streptomyces coelicolor (218 aa); and CAC01371.1|AL390975 putative tetR-family transcriptional regulator from Streptomyces coelicolor (228 aa). Also similar to AL0212|MTV012_65 from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 327, E(): 1.8e-15, (31.0% identity in 232 aa overlap); and Z95120|MTCY07D11.18c (228 aa), FASTA scores: opt: 190,E(): 4.4e-06, (23.1% identity in 186 aa overlap). Contains probable helix-turn-helix doimain at aa 45-66 (Score 1429,+4.05 SD). Q7U1X1 No regulatory proteins Rv0472c NC_002945.3 Mycobrowser_v2 CDS 564583 565953 . + 0 Mb0483 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0483, -, len: 456 aa. Equivalent to Rv0473, len: 456 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 456 aa overlap). Possible conserved transmembrane protein, showing some similarity to hypothetical proteins e.g. NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical protein from Mesorhizobium loti (431 aa); P39385|YJIN_ECOLI|YJIN|B4336 HYPOTHETICAL 48.2 KD PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain K12 (426 aa), FASTA scores: opt: 396, E(): 9.8e-19, (31.8 % identity in 424 aa overlap); etc. Q7U1X0 No cell wall and cell processes Rv0473 NC_002945.3 Mycobrowser_v2 CDS 566040 566462 . + 0 Mb0484 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0484, -, len: 140 aa. Equivalent to Rv0474, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable transcriptional regulator, highly similar to others e.g. CAC04034.1|AL391406 putative DNA-binding protein from Streptomyces coelicolor (141 aa); N-terminus of NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional regulator from Mesorhizobium loti (219 aa); N-terminus of A83618|PA0225 probable transcription regulator from Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr protein from Bacillus subtilis (111 aa), FASTA scores: opt: 147, E(): 8.9e-06, (30.6% identity in 111 aa overlap). Also similar to other hypothetical proteins e.g. X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa),FASTA scores: opt: 280, E(): 4.8e-12, (43.6% identity in 117 aa overlap). Also similar to Rv2745c from Mycobacterium tuberculosis. Contains probable helix-turn-helix domain at aa 35-56 (Score 1709, +5.01 SD). Q7U1W9 No regulatory proteins Rv0474 NC_002945.3 Mycobrowser_v2 CDS 566816 567415 . + 0 Mb0485 hbhA iron-regulated heparin binding hemagglutinin hbha (adhesin) Mb0485, hbhA, len: 199 aa. Equivalent to Rv0475,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). hbhA, heparin-binding hemagglutinin (see citations below), equivalent to CAC31971.1|AL583925 possible hemagglutinin from Mycobacterium leprae (188 aa). Contains possible N-terminal signal sequence and K-A-rich region at C-terminus: SUBCELLULAR LOCATION: SURFACE ASSOCIATED. X2BF49,P0C2T3 No cell wall and cell processes Rv0475 NC_002945.3 Mycobrowser_v2 CDS 567527 567790 . + 0 Mb0486 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0486, -, len: 87 aa. Equivalent to Rv0476, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Possible conserved transmembrane protein, equivalent to CAC31970.1|AL583925 conserved membrane protein from Mycobacterium leprae (95 aa). Also highly similar to CAC04036.1|AL391406 putative membrane protein from Streptomyces coelicolor (113 aa). Contains PS00606 Beta-ketoacyl synthases active site. X2BF48,P64696 No cell wall and cell processes Rv0476 NC_002945.3 Mycobrowser_v2 CDS 622057 623274 . + 0 Mb0543 conserved protein Mb0543, -, len: 405 aa. Equivalent to Rv0530, len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. AL031231|SC3C3_3|CAA20252.1 from Streptomyces coelicolor (1083 aa), FASTA scores: opt: 870, E(): 0, (39.5% identity in 443 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3868, Rv0282, Rv1798, etc. Q7U1U4 No conserved hypotheticals Rv0530 NC_002945.3 Mycobrowser_v2 CDS 568241 568915 . + 0 Mb0488 deoC PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE) Mb0488, deoC, len: 224 aa. Equivalent to Rv0478,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable deoC,deoxyribose-phosphate aldolase (EC 4.1.2.4), equivalent to Q9CB45|DEOC_MYCLE DEOXYRIBOSE-PHOSPHATE ALDOLASE from M. leprae (226 aa). Also highly similar to others e.g. DEOC_BACSU|P39121 from Bacillus subtilis (214 aa), FASTA scores: opt: 543, E(): 1.4e-26, (45.9% identity in 209 aa overlap); etc. BELONGS TO THE DEOC/FBAB FAMILY OF ALDOLASES, DEOC SUBFAMILY. X2BF23,P63930 No intermediary metabolism and respiration Rv0478 NC_002945.3 Mycobrowser_v2 CDS 568940 569986 . - 0 Mb0489c PROBABLE CONSERVED MEMBRANE PROTEIN Mb0489c, -, len: 348 aa. Equivalent to Rv0479c,len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 348 aa overlap). Probable conserved membrane protein, equivalent to CAC31967.1|AL583925 possible secreted protein from Mycobacterium leprae (254 aa); and C-terminus highly similar to AAF74996.1|AF143402_1|AF143402 putative multicopper oxidase from Mycobacterium avium (149 aa). Contains hydrophobic domain in centre of protein. X2BF60,P64700 No cell wall and cell processes Rv0479c NC_002945.3 Mycobrowser_v2 CDS 589476 590318 . + 0 Mb0509 CONSERVED HYPOTHETICAL PROTEIN Mb0509, -, len: 280 aa. Equivalent to Rv0498, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to P54581|Y498_MYCLE|ML2432 HYPOTHETICAL 30.5 KDA PROTEIN from Mycobacterium leprae (280 aa); and S72896|B2168_C2_210 hypothetical protein from Mycobacterium leprae (244 aa), FASTA scores: opt: 1486,E():0, (89.3% identity in 244 aa overlap). Also similar to Q9X8H0|Y714_STRCO|SCE7.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor. X2BF84 No conserved hypotheticals Rv0498 NC_002945.3 Mycobrowser_v2 CDS 569983 570918 . - 0 Mb0490c possible amidohydrolase Mb0490c, -, len: 311 aa. Equivalent to Rv0480c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Conserved hypothetical protein, equivalent, but longer 60 aa in N-terminus, to CAC31966.1|AL583925 putative hydrolase from Mycobacterium leprae (271 aa). Also similar to several hypothetical proteins and hydrolases e.g. AL096822|SCGD3_8 probable hydrolase from Streptomyces coelicolor (264 aa),FASTA scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa overlap); and YAUB_SCHPO|Q10166 hypothetical 35.7 kd protein c26a3.11 from S. pombe (322 aa), FASTA scores: opt: 338, E():1.4e-13, (30.3% identity in 277 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (329 aa versus 340 aa). Q7U1W8 No intermediary metabolism and respiration Rv0480c NC_002945.3 Mycobrowser_v2 CDS 595022 595930 . - 0 Mb0515c cmaA2 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID TRANS-CYCLOPROPANE SYNTHETASE) Mb0515c, cmaA2, len: 302 aa. Equivalent to Rv0503c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). cmaA2 (alternate gene name: cma2), cyclopropane-fatty-acyl-phospholipid synthase 2 (mycolic acid trans-cyclopropane synthetase) (EC 2.1.1.79) (see citations below). Note that this protein has 302 aa and not 322 aa: we have chosen a different initiation codon on the basis of homology). Equivalent to S72886|B2168_F3_130 hypothetical protein from Mycobacterium leprae (308 aa), FASTA score: (78.9% identity in 303 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also similar to other proteins from Mycobacterium tuberculosis and Mycobacterium bovis BCG e.g. MTV038_14|UMAA2|Rv0470c|MTV038.14 PUTATIVE MYCOLIC ACID SYNTHESIS/MODIFICATION PROTEIN (287 aa) (57.2% identity in 297 aa overlap). X2BFA2,P0A5P1 No NC_002945.3 Mycobrowser_v2 CDS 571502 572611 . + 0 Mb0492 murB PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE) Mb0492, murB, len: 369 aa. Equivalent to Rv0482,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Probable murB,UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158), equivalent to CAC31964.1|AL583925 UDP-N-acetylenolpyruvoylglucosamine reductase from Mycobacterium leprae (367 aa). Also highly similar to others e.g. MURB_ECOLI|P08373 UDP-N-acetylenolpyruvoylglucosamine reductase from Escherichia coli (342 aa), FASTA scores: opt: 292, E(): 6.3e-12, (33.5% identity in 355 aa overlap); etc. BELONGS TO THE MURB FAMILY. COFACTOR: FAD. X2BF62,P65461 No cell wall and cell processes Rv0482 NC_002945.3 Mycobrowser_v2 CDS 572673 574028 . + 0 Mb0493 lprQ PROBABLE CONSERVED LIPOPROTEIN LPRQ Mb0493, lprQ, len: 451 aa. Equivalent to Rv0483,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). Probable lprQ,conserved lipoprotein, equivalent to CAC31963.1|AL583925|ML2446 possible lipoprotein from Mycobacterium leprae (441 aa); appears longer than ML2446,so start may be further downstream. Shows also similarity with MLCL383_24|O07707 HYPOTHETICAL 43.6 KD PROTEIN from Mycobacterium leprae; and to Q49706|B1496_F2_81 (271 aa). Similar to others lipoproteins from other organisms. Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0116c, Rv0192, Rv1433, Rv2518c. Contains potential N-terminal signal sequence and appropriately positioned PS00013 prokaryotic membrane lipoprotein lipid attachment site. X2BF28,P64704 No cell wall and cell processes Rv0483 NC_002945.3 Mycobrowser_v2 CDS 574009 574764 . - 0 Mb0494c probable short-chain type oxidoreductase Mb0494c, -, len: 251 aa. Equivalent to Rv0484c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Probable short-chain oxidoreductase (EC 1.-.-.-), highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. STRONG SIMILARITY,TO BACTERIAL YDFG HOMOLOGS. Q7U1W7 No intermediary metabolism and respiration Rv0484c NC_002945.3 Mycobrowser_v2 CDS 666676 666843 . - 0 Mb0587A HYPOTHETICAL PROTEIN Mb0587A, -, len: 55 aa. Equivalent to Mt0407.1 from Mycobacterium tuberculosis strain CDC1551, (100% identity with 55 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb0587A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BFF4 No NC_002945.3 Mycobrowser_v2 CDS 574947 576263 . + 0 Mb0495 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0495, -, len: 438 aa. Equivalent to Rv0485, len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Possible transcriptional repressor, member of the NAGC/XYLR repressor FAMILY; similar to several e.g. D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor from Vibrio cholerae (404 aa), FASTA scores: opt: 378,E(): 1.2e-17, (26.9% identity in 350 aa overlap); NAGC_ECOLI|P15301 N-acetylglucosamine repressor from Escherichia coli (406 aa), FASTA scores: opt: 305, E(): 1.8e-12, (21.8% identity in 357 aa overlap); etc. X2BF70 No regulatory proteins Rv0485 NC_002945.3 Mycobrowser_v2 CDS 590334 591209 . + 0 Mb0510 CONSERVED HYPOTHETICAL PROTEIN Mb0510, -, len: 291 aa. Equivalent to Rv0499, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Conserved hypothetical protein, showing some similarity to AL031184|SC2A11_16|T34762 hypothetical protein from Streptomyces coelicolor (340 aa), FASTA scores: opt: 240,E(): 1.8e-07, (28.9% identity in 270 aa overlap). X2BF78,P64720 No conserved hypotheticals Rv0499 NC_002945.3 Mycobrowser_v2 CDS 576311 577753 . + 0 Mb0496 msha glycosyltransferase msha Mb0496, -, len: 480 aa. Equivalent to Rv0486, len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Mannosyltransferase (EC 2.4.1.-) (see citations below), highly similar to P54138|Y486_MYCLE|ML2443 possible glycosyl transferase from Mycobacterium leprae (428 aa); and S72892|B2168_C2_201 probable hexosyltransferase (EC 2.4.1.-) from Mycobacterium leprae (409 aa), FASTA scores: opt: 2375, E(): 0, (86.4% identity in 413 aa overlap). Also highly similar to CAC04040.1|AL391406 putative transferase from Streptomyces coelicolor (496 aa); and similar to various transferases e.g. NP_437172.1|NC_003078 putative membrane-anchored glycosyltransferase protein from Sinorhizobium meliloti (416 aa); O26550|U67601_1 LPS BIOSYNTHESIS RELATED PROTEIN from Methanococcus jannaschii (411 aa), FASTA score: (25.3% identity in 387 aa overlap); etc. Also similar to CAC87824.1|AJ316594 putative sucrose-phosphate synthase from Nostoc punctiforme (422 aa). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature. X2BF79,P64708 No intermediary metabolism and respiration Rv0486 NC_002945.3 Mycobrowser_v2 CDS 577750 578301 . + 0 Mb0497 CONSERVED HYPOTHETICAL PROTEIN Mb0497, -, len: 183 aa. Equivalent to Rv0487, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, highly similar to P54139|Y487_MYCLE|U00018_38|ML2442 HYPOTHETICAL 20.8 KDA PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa overlap). Also highly similar to CAC04041.1|AL391406 conserved hypothetical protein from Streptomyces coelicolor (168 aa). X2BF77 No conserved hypotheticals Rv0487 NC_002945.3 Mycobrowser_v2 CDS 578685 579290 . + 0 Mb0498 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0498, -, len: 201 aa. Equivalent to Rv0488, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to others and conserved hypothetical proteins e.g. AB93746.1|AL357613 putative membrane transport protein from Streptomyces coelicolor (204 aa); D83100|PA4365 probable transporter from Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667 hypothetical 21.7 kd protein from Escherichia coli (197 aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity in 179 aa overlap); CGLYSEG_2 C|P94633 LYSINE EXPORTER PROTEIN (236 aa), FASTA scores: E(): 2.3e-07, (33.3% identity in 219 aa overlap). Also similar to Rv1986 from Mycobacterium tuberculosis. X2BF53,P64712 No cell wall and cell processes Rv0488 NC_002945.3 Mycobrowser_v2 CDS 579447 580196 . + 0 Mb0499 gpm1 PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) Mb0499, gpm1, len: 249 aa. Equivalent to Rv0489,len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Probable gpm1,phosphoglycerate mutase 1 (EC 5.4.2.1), equivalent to P53531|PMGY_MYCLE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (247 aa). Also highly similar to others e.g. PMG1_ECOLI|P31217 (249 aa), FASTA scores: opt: 805, E(): 0, (51.4% identity in 245 aa overlap); etc. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOSPHOGLYCERATE MUTASE FAMILY. Note that previously known as gpm. X2BF75,P0A5R7 No intermediary metabolism and respiration Rv0489 NC_002945.3 Mycobrowser_v2 CDS 580370 581602 . + 0 Mb0500 senX3 PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 Mb0500, senX3, len: 410 aa. Equivalent to Rv0490,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 410 aa overlap). Putative senX3,two-component sensor histidine kinase (EC 2.7.3.-),transmembrane protein (see citations below), equivalent to O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0,(99.5% identity in 410 aa overlap); and highly similar to P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from Mycobacterium leprae (443 aa), FASTA score: (83.8% identity in 408 aa overlap). Also highly similar, except in N-terminus, to CAC31957.1|AL583925 probable two-component system sensor histidine kinase from Mycobacterium leprae (441 aa). Also highly similar to sensor kinase proteins from other organisms e.g. CAB77323.1|AL160331 putative sensor kinase protein from Streptomyces coelicolor (426 aa). X2BF71,P0A601 No NC_002945.3 Mycobrowser_v2 CDS 581960 582643 . + 0 Mb0501 regX3 TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) Mb0501, regX3, len: 227 aa. Equivalent to Rv0491,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). regX3, response regulator protein (sensory transduction protein) (see citations below), equivalent to O07130|RGX3_MYCBO|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium bovis BCG (227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response regulator from Mycobacterium smegmatis (228 aa); equivalent to P54884|RGX3_MYCLE|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium leprae (198 aa), FASTA scores : E(): 0, (95.4% identity in 197 aa overlap). Also highly similar to other response regulators e.g. AAG43239.1|AF123314_2 |AF123314 putative response regulator from Corynebacterium glutamicum (232 aa). X2BF91,O07130 No NC_002945.3 Mycobrowser_v2 CDS 582640 584529 . - 0 Mb0502c PROBABLE OXIDOREDUCTASE GMC-TYPE Mb0502c, -, len: 629 aa. Equivalent to Rv0492c,len: 629 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 629 aa overlap). Probable oxidoreductase GMC type (EC 1.-.-.-), similar to others except in N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN HYPOTHETICAL GMC-TYPE OXIDOREDUCTASE from Rhizobium sp. (505 aa), FASTA scores: opt: 873, E():0, (34.3% identity in 502 aa overlap); YTH2_RHOER|P46371 HYPOTHETICAL 53.0 kd GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa), FASTA score: (25.7% identity in 521 aa overlap); YTH2_RHOSO|P46371 hypothetical 53.0 kd gmc-type oxidoreductase from Rhodococcus erythropolis (493 aa),FASTA score: (25.7% identity in 521 aa overlap); NP_085596.1|NC_002679 probable oxidoreductase from Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC oxidoreductase from Deinococcus radiodurans (722 aa); NP_249055.1|NC_002516 probable oxidoreductase from Pseudomonas aeruginosa (531 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD (BY SIMILARITY). Note that start changed since first submission (previously 684 aa). Q7U1W6 No intermediary metabolism and respiration Rv0492c NC_002945.3 Mycobrowser_v2 CDS 585846 586574 . + 0 Mb0505 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0505, -, len: 242 aa. Equivalent to Rv0494, len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Probable transcriptional regulator, GntR family, with C-terminal part highly similar to S72893|B2168_C2_205 hypothetical protein from Mycobacterium leprae (105 aa). Also similar to other transcription regulators e.g. PDHR_ECOLI|P06957 pyruvate dehydrogenase complex repressor PDHR or GENA from Escherichia coli (254 aa), FASTA scores: opt: 284, E(): 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature, and probable helix-turn helix motif from aa 50-71 (Score 1229, +3.37 SD). X2BF74,P67740 No regulatory proteins Rv0494 NC_002945.3 Mycobrowser_v2 CDS 586575 587465 . - 0 Mb0506c CONSERVED HYPOTHETICAL PROTEIN Mb0506c, -, len: 296 aa. Equivalent to Rv0495c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Conserved hypothetical protein, highly similar to S72915|B2168_F1_37 hypothetical protein from Mycobacterium leprae (323 aa),FASTA scores: opt: 1615, E(): 0, (82.7% identity in 271 aa overlap); and P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (271 aa). X2BF95 No conserved hypotheticals Rv0495c NC_002945.3 Mycobrowser_v2 CDS 587545 588531 . + 0 Mb0507 CONSERVED HYPOTHETICAL PROTEIN Mb0507, -, len: 328 aa. Equivalent to Rv0496, len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 328 aa overlap). Conserved hypothetical protein, highly similar to S72894|467046|AAA17230.1|U00018 exopolyphosphatase (EC 3.6.1.11) ppx from Mycobacterium leprae (406 aa), FASTA scores: opt: 1902, E(): 0, (86.6% identity in 343 aa overlap); and P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium leprae (339 aa). Also highly similar to hypothetical proteins and exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa). C-terminal region similar to CGU31224_1|Q46054 protein similar to ppx gene product of Mycobacterium leprae from Cornybacterium glutamicum (140 aa), FASTA scores: opt: 615, E(): 2.7e-33, (70.9% identity in 134 aa overlap). X2BF85,P65787 No conserved hypotheticals Rv0496 NC_002945.3 Mycobrowser_v2 CDS 588528 589460 . + 0 Mb0508 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0508, -, len: 310 aa. Equivalent to Rv0497, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Probable conserved transmembrane protein, equivalent (but shorter in C-terminus) to P54580|Y497_MYCLE|ML2433 HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium leprae (355 aa). N-terminus highly similar to S72922|B2168_C1_166|467074 hypothetical protein from Mycobacterium leprae (118 aa), FASTA scores: opt: 350, E(): 1.4e-12, (57.9% identity in 114 aa overlap); and hydrophobic C-terminus, highly similar to S72895|B2168_C2_209|467047 hypothetical protein from Mycobacterium leprae (241 aa), FASTA scores: opt: 473,E(): 8e-19, (53.9% identity in 241 aa). X2BF59,P64716 No cell wall and cell processes Rv0497 NC_002945.3 Mycobrowser_v2 CDS 1453212 1453454 . + 0 Mb1330 rpmE 50s ribosomal protein l31 rpme Mb1330, rpmE, len: 80 aa. Equivalent to Rv1298,len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 80 aa overlap). Probable rpmE, 50s ribosomal protein L31, highly similar to many e.g. RL31_MYCLE|P45834 50s ribosomal protein L31 from Mycobacterium leprae (84 aa), FASTA scores: opt: 490, E(): 5.5e-28, (89.6% identity in 77 aa overlap). Contains PS01143 Ribosomal protein L31 signature. BELONGS TO THE L31P FAMILY OF RIBOSOMAL PROTEINS. X2BHB4,P66188 No information pathways Rv1298 NC_002945.3 Mycobrowser_v2 CDS 621041 622015 . + 0 Mb0542 ccsA POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCSA Mb0542, ccsA, len: 324 aa. Equivalent to Rv0529,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Possible ccsA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to NP_302558.1|NC_002677|B2168_C3_281 possible cytochrome C biogenesis protein from Mycobacterium leprae (327 aa), FASTA scores: opt: 1779,E(): 0, (82.9% identity in 327 aa overlap). Also highly similar to others e.g. CAC08382.1|AL392176 putative cytochrome biogenesis related protein from Streptomyces coelicolor (380 aa); CCSA_CHLRE|P48269 probable cytochrome c biogenesis protein from Chlamydomonas reinhardtii (353 aa), FASTA scores: opt: 449, E(): 1.3e-23, (34.4% identity in 247 aa overlap); etc. BELONGS TO THE CCMF/CYCK/CCL1/NRFE/CCSA FAMILY. Note that previously known as ccsB. Q7U1U5 No intermediary metabolism and respiration Rv0529 NC_002945.3 Mycobrowser_v2 CDS 591234 592121 . + 0 Mb0511 proC PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C REDUCTASE) Mb0511, proC, len: 295 aa. Equivalent to Rv0500,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable proC,Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (see citation below), equivalent to P46725|PROC_MYCLE PYRROLINE-5-CARBOXYLATE REDUCTASE from Mycobacterium leprae (294 aa), FASTA scores: opt: 1473, E(): 0, (82.4% identity in 295 aa overlap). Also similar to others e.g. P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTASE from Corynebacterium glutamicum (270 aa); T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate reductase from Streptomyces coelicolor (284 aa); etc. BELONGS TO THE PYRROLINE-5-CARBOXYLATE REDUCTASE FAMILY. Q7U1W3 No intermediary metabolism and respiration Rv0500 NC_002945.3 Mycobrowser_v2 CDS 592262 592498 . + 0 Mb0512 conserved protein Mb0512, -, len: 78 aa. Equivalent to Rv0500A, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): 1.3e-27, (82.6% identity in 86 aa overlap); AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 identity in 54 aa overlap). Q7U1W2 No conserved hypotheticals Rv0500A NC_002945.3 Mycobrowser_v2 CDS 592626 592727 . + 0 Mb0512A Conserved hypothetical protein Mb0512A, len: 33 aa. Equivalent to Rv0500B len: 33 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 33 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein. Basic protein 18 of the 33 aa are Arg or Lys,with strong similarity to AL079345|SCE68_25 protein from Streptomyces coelicolor cosmid E6 (32 aa), FASTA scores: opt: 176, E(): 1e-06, (93.1% identity in 29 aa overlap). Same gene arrangement in both actinomycetes. X2BF61 No conserved hypotheticals Rv0500B NC_002945.3 Mycobrowser_v2 CDS 592805 593935 . + 0 Mb0513 galE2 POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE) Mb0513, galE2, len: 376 aa. Equivalent to Rv0501,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible galE2,UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar (except in N-terminus) to CAC31944.1|AL583925 possible glucose epimerase/dehydratase from Mycobacterium leprae (364 aa). N-terminus highly similar to S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical protein from Mycobacterium leprae (180 aa), FASTA scores: opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and C-terminus highly similar to S72898|467050|AAA17234.1|U00018 hypothetical protein from Mycobacterium leprae (168 aa), FASTA scores: opt: 928,E(): 0, (82.7% identity in 168 aa overlap). Also highly similar to T36274|5123671|CAB45360.1|AL079345 probable epimerase from Streptomyces coelicolor (353 aa); and similar in part to other epimerases e.g. GALE_ECOLI|P09147 UDP-glucose 4-epimerase from Escherichia coli (338 aa),FASTA scores: opt: 241, E(): 6.7e-09, (28.2% identity in 294 aa overlap); etc. BELONGS TO THE SUGAR EPIMERASE FAMILY. COFACTOR: NAD. Note that previously known as galE1. X2BF87,P0A5D2 No NC_002945.3 Mycobrowser_v2 CDS 593942 595018 . + 0 Mb0514 conserved protein Mb0514, -, len: 358 aa. Equivalent to Rv0502, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Conserved hypothetical protein, equivalent to P54878|Y502_MYCLE|ML2427 HYPOTHETICAL 40.5 KDA PROTEIN from Mycobacterium leprae (367 aa), FASTA scores: opt: 2042, E(): 0, (84.1% identity in 365 aa overlap). Also similar to T36273|SCE68.23c hypothetical protein from Streptomyces coelicolor (355 aa). C-terminal similar to AL021529|SC10A5_4|T34572 hypothetical protein from Streptomyces coelicolor (295 aa), FASTA score: (57.8% identity in 263 aa overlap); and to hypothetical proteins from Mycobacterium tuberculosis Rv1920|G70808 (287 aa); and Rv1428c|G70914 (275 aa). X2BF83,P64724 No conserved hypotheticals Rv0502 NC_002945.3 Mycobrowser_v2 CDS 595953 596453 . - 0 Mb0516c conserved protein Mb0516c, -, len: 166 aa. Equivalent to Rv0504c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, equivalent to P54879|Y504_MYCLE|ML2425 HYPOTHETICAL 18.7 KDA PROTEIN from Mycobacterium leprae (166 aa), FASTA scores: opt: 884, E(): 0, (83.1% identity in 166 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). Also similar to M. tuberculosis hypothetical proteins Rv0635|H70612 (158 aa); and Rv0637|B70613 (166 aa). X2BF94 No conserved hypotheticals Rv0504c NC_002945.3 Mycobrowser_v2 CDS 596615 597736 . - 0 Mb0517c serB1 POSSIBLE PHOSPHOSERINE PHOSPHATASE SERB1 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE) Mb0517c, serB1, len: 373 aa. Equivalent to Rv0505c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Possible serB1,phosphoserine phosphatase (EC 3.1.3.3), equivalent (but longer ~70 aa in N-terminus) to S72914|serB phosphoserine phosphatase from Mycobacterium leprae (300 aa), FASTA scores: opt: 1570, E(): 0, (83.0% identity in 306 aa overlap). C-terminus highly similar to CAB55344.1|AJ010584 phosphoserine phosphatase from Streptomyces coelicolor (266 aa). Low similarity to SERB_ECOLI|P06862 phosphoserine phosphatase from Escherichia coli strains K12 and O157:H7 (322 aa), FASTA scores: opt: 148, E(): 0.043, (24.0% identity in 150 aa overlap). C-terminus is also similar to O33611|AB004855_1|IMD_STRCN PROTEIN INVOLVED IN INHIBITION OF MORPHOLOGICAL DIFFERENTIATION from Streptomyces cyaneus (277 aa), FASTA score: (37.7% identity in 252 aa overlap). SEEMS TO BELONG TO THE SERB FAMILY. Note that previously known as serB. X2BF63,P66802 No NC_002945.3 Mycobrowser_v2 CDS 597910 598353 . + 0 Mb0518 mmpS2 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS2 Mb0518, mmpS2, len: 147 aa. Equivalent to Rv0506,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Probable mmpS2,conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. C-terminus of AAD44232.1|AF143772_38|AF143772|TmtpA from M. avium (221 aa); P54880|MMS4_MYCLE|MMPS4 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 392, E(): 1.3e-20, (43.7% identity in 151 aa overlap); and the PUTATIVE MEMBRANE PROTEINS from Mycobacterium tuberculosis MTV040_5, MTCY4D9_16, MTV037_15. BELONGS TO THE MMPS FAMILY. X2BF92,P65377 No NC_002945.3 Mycobrowser_v2 CDS 647541 649205 . + 0 Mb0570 menD PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE) (KDC) Mb0570, menD, len: 554 aa. Equivalent to Rv0555,len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 554 aa overlap). Probable menD,menaquinone biosynthesis protein, including 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.1.3.-) and 2-oxoglutarate decarboxylase (EC 4.1.1.71) activities. Equivalent to NP_302478.1|NC_002677 putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase from Mycobacterium leprae (556 aa). Also similar to others e.g. MEND_BACSU|P23970 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase from Bacillus subtilis (548 aa), FASTA scores: opt: 488, E(): 2.3e-21, (34.3% identity in 545 aa overlap); etc. COFACTOR: THIAMINE PYROPHOSPHATE. X2BFE4,Q7U1S4 No intermediary metabolism and respiration Rv0555 NC_002945.3 Mycobrowser_v2 CDS 598350 601256 . + 0 Mb0519 mmpL2 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL2 Mb0519, mmpL2, len: 968 aa. Equivalent to Rv0507,len: 968 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 968 aa overlap). Probable mmpL2,conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCLE from Mycobacterium leprae (959 aa), FASTA scores: opt: 3699, E(): 0, (58.3% identity in 940 aa overlap); and the Mycobacterium tuberculosis proteins MTV037_14, MTV040_4, MTCY98_8,MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc. Also similar to STMACTII_3|SC10A5_9 from Streptomyces coelicolor; and BSUB0|004_12 from Bacillus subtilis. C-terminal half similar to Q50086|U1740AB from Mycobacterium leprae (386 aa), FASTA scores: opt: 1526,E(): 0, (61.5% identity in 371 aa overlap). BELONGS TO THE MMPL FAMILY. Q7U1W1 No NC_002945.3 Mycobrowser_v2 CDS 601249 601542 . + 0 Mb0520 CONSERVED HYPOTHETICAL PROTEIN Mb0520, -, len: 97 aa. Equivalent to Rv0508, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, showing similarity with T36269|5123666|CAB45355.1|AL079345 probable redoxin from Streptomyces coelicolor (101 aa), FASTA scores: opt: 160,E(): 3.4e-05, (33.3% identity in 75 aa overlap); and E81943|NMA0966 probable thioredoxin from Neisseria meningitidis group A strain Z2491 (77 aa). X2BFA6 No conserved hypotheticals Rv0508 NC_002945.3 Mycobrowser_v2 CDS 601592 602998 . + 0 Mb0521 hemA probable glutamyl-trna reductase hema (glutr) Mb0521, hemA, len: 468 aa. Equivalent to Rv0509,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable hemA,glutamyl-tRNA reductase (EC 1.2.1.-), equivalent to HEM1_MYCLE|P46724 GLUTAMYL-TRNA REDUCTASE from Mycobacterium leprae (467 aa), FASTA scores: opt: 2377,E(): 0, (82.3% identity in 463 aa overlap). Also highly similar (sometimes in part) to others e.g. Q9WX15|HEM1_STRCO GLUTAMYL-TRNA REDUCTASE from Streptomyces coelicolor (581 aa); P16618|HEM1_BACSU|HEMA GLUTAMYL-TRNA REDUCTASE from Bacillus subtilis (455 aa); etc. Contains PS00747 Glutamyl-tRNA reductase signature. BELONGS TO THE GLUTAMYL-TRNA REDUCTASE FAMILY. X2BFA0,P64329 No intermediary metabolism and respiration Rv0509 NC_002945.3 Mycobrowser_v2 CDS 603008 603937 . + 0 Mb0523 hemC PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE) Mb0523, hemC, len: 309 aa. Equivalent to Rv0510,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable hemC,hydroxymethylbilane synthase (porphobilinogen deaminase) (EC 4.3.1.8), equivalent to HEM3B|Q49808|HEM3_MYCLE PORPHOBILINOGEN DEAMINASE from Mycobacterium leprae (315 aa), FASTA scores: opt: 889, E(): 0, (88.1% identity in 159 aa overlap). Also highly similar to others e.g. Q9WX16|HE31_STRCO PROBABLE PORPHOBILINOGEN DEAMINASE from Streptomyces coelicolor (319 aa); Q9L6Q2|HEM3_SALTY PORPHOBILINOGEN DEAMINASE from Salmonella typhimurium (313 aa); etc. BELONGS TO THE HMBS FAMILY. COFACTOR: COVALENTLY BINDS A DIPYRROMETHANE COFACTOR TO WHICH THE PORPHOBILINOGEN SUBUNITS ARE ADDED. X2BF64,P64337 No intermediary metabolism and respiration Rv0510 NC_002945.3 Mycobrowser_v2 CDS 603970 605667 . + 0 Mb0524 hemD PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM) Mb0524, hemD, len: 565 aa. Equivalent to Rv0511,len: 565 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 565 aa overlap). Probable hemD (alternate gene name: cysG), uroporphyrin-III C-methyltransferase (EC 2.1.1.107), highly similar to others e.g. CAC31936.1|AL583925 possible uroporphyrin-III C-methyltransferase from Mycobacterium leprae (563 aa); and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA scores: opt: 1946, E(): 0, (83.3% identity in 472 aa overlap); T36265|5123662|CAB45351.1|AL079345 probable uroporphyrin-III C-methyltransferase from Streptomyces coelicolor (565 aa); and similar to others e.g. AAK00606.1|AF221100_3|AF221100 from Selenomonas ruminantium subsp. ruminantium (505 aa); etc. Also similar to Rv2071c and Rv2847c from Mycobacterium tuberculosis. Note that previously known as cysG. Q7TTP7 No intermediary metabolism and respiration Rv0511 NC_002945.3 Mycobrowser_v2 CDS 605753 606742 . + 0 Mb0525 hemB PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) Mb0525, hemB, len: 329 aa. Equivalent to Rv0512,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 329 aa overlap). Probable hemB,delta-aminolevulinic acid dehydratase (EC 4.2.1.24),equivalent to 46723|HEM2_MYCLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE from Mycobacterium leprae (329 aa). Also highly similar to many e.g. P54919|HEM2_STRCO from Streptomyces coelicolor (330 aa); HEM2_ECOLI|P15002 from Escherichia coli (323 aa), FASTA scores: opt: 942, E(): 0,(47.6% identity in 317 aa overlap); etc. Contains PS00169 Delta-aminolevulinic acid dehydratase active site. BELONGS TO THE ALADH FAMILY. COFACTOR: ZINC. Q7U1W0 No intermediary metabolism and respiration Rv0512 NC_002945.3 Mycobrowser_v2 CDS 606755 607303 . + 0 Mb0526 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0526, -, len: 182 aa. Equivalent to Rv0513, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Possible conserved transmembrane protein, with its N-terminus highly similar to S72925|B2168_C1_182 hypothetical protein from Mycobacterium leprae (103 aa), FASTA scores: opt: 217,E(): 8.2e-14, (45.3 % identity in 106 aa overlap). Q7U1V9 No cell wall and cell processes Rv0513 NC_002945.3 Mycobrowser_v2 CDS 607702 609213 . + 0 Mb0528 CONSERVED 13E12 REPEAT FAMILY PROTEIN Mb0528, -, len: 503 aa. Equivalent to Rv0515, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Part of M. tuberculosis 13E12 repeat family. Almost identical to Rv0336 (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other M. tuberculosis hypothetical 13E12 repeat proteins e.g. Rv1148c, Rv1945, etc. Q7TTD9 No insertion seqs and phages Rv0515 NC_002945.3 Mycobrowser_v2 CDS 609210 609686 . - 0 Mb0529c possible anti-anti-sigma factor Mb0529c, -, len: 158 aa. Equivalent to Rv0516c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, showing some similarity to Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 aa), FASTA scores: E(): 0.0012, (27.4% identity in 124 aa overlap). Q7U1V7 No information pathways Rv0516c NC_002945.3 Mycobrowser_v2 CDS 1371536 1372069 . - 0 Mb1259c PROBABLE TRANSMEMBRANE PROTEIN Mb1259c, -, len: 177 aa. Equivalent to Rv1227c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 177 aa overlap). Possible transmembrane protein, similar to P96615 hypothetical protein ydbS from Bacillus subtilis (159 aa), fasta scores: E(): 3.6e-07,(30.1% identity in 163 aa overlap). Q7U0C4 No cell wall and cell processes Rv1227c NC_002945.3 Mycobrowser_v2 CDS 649202 649717 . + 0 Mb0571 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0571, -, len: 171 aa. Equivalent to Rv0556, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 171 aa overlap). Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa). Q7U1S3 No cell wall and cell processes Rv0556 NC_002945.3 Mycobrowser_v2 CDS 609897 611207 . + 0 Mb0530 POSSIBLE MEMBRANE ACYLTRANSFERASE Mb0530, -, len: 436 aa. Equivalent to Rv0517, len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 436 aa overlap). Possible acyltransferase (EC 2.3.1.-), integral membrane protein,equivalent (but longer 26 aa in N-terminus) to AAK44761.1|AE006954 putative acyltransferase from Mycobacterium tuberculosis strain CDC1551 (410 aa). Also similar to many acyltransferases e.g. MDMB_STRMY|Q00718 from Streptomyces mycarofaciens (387 aa), FASTA scores: opt: 200, E(): 1.1e-08, (28.2% identity in 394 aa overlap). And similar to Rv0111, Rv0228, Rv1254, Rv1565c from Mycobacterium tuberculosis. Q7U1V6 No intermediary metabolism and respiration Rv0517 NC_002945.3 Mycobrowser_v2 CDS 611339 612034 . + 0 Mb0531 POSSIBLE EXPORTED PROTEIN Mb0531, -, len: 231 aa. Equivalent to Rv0518, len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible exported protein; has hydrophobic N-terminus. Q7U1V5 No cell wall and cell processes Rv0518 NC_002945.3 Mycobrowser_v2 CDS 612322 613224 . - 0 Mb0532c POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0532c, -, len: 300 aa. Equivalent to Rv0519c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Possible conserved membrane protein, with hydrophobic region near N-terminus. Could be a lipase (EC 3.1.-.-). Similar to Rv0774c|MTCY369.19c|A70708 from Mycobacterium tuberculosis (312 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00120 Lipases, serine active site. Q7U1V4 No cell wall and cell processes Rv0519c NC_002945.3 Mycobrowser_v2 CDS 641881 642147 . - 0 Mb0565c vapb3 possible antitoxin vapb3 Mb0565c, -, len: 88 aa. Equivalent to Rv0550c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein. Q7U1S8 No virulence, detoxification, adaptation Rv0550c NC_002945.3 Mycobrowser_v2 CDS 613405 613755 . + 0 Mb0533 POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT) Mb0533, -, len: 116 aa. Equivalent to Rv0520, len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). Possible fragment of methyltransferase (possibly first part) (EC 2.1.1.-),highly similar to part of several methyltransferases e.g. Q43445|U43683 S-ADENOSYL-L-METHIONINE:DELTA24-STEROL-C-METHYLTRANSFERASE from Glycine max (Soybean)(367 aa), FASTA scores: opt: 190, E(): 2.3e-12, (39.2% identity in 74 aa overlap). Also some similarity to MTCY19G5_5 from Mycobacterium tuberculosis. Possibly continues as Rv0521 but we can find no frameshift to account for this. Q7U1V3 No intermediary metabolism and respiration Rv0520 NC_002945.3 Mycobrowser_v2 CDS 613748 614053 . + 0 Mb0534 POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT) Mb0534, -, len: 101 aa. Equivalent to Rv0521, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Possible fragment of methyltransferase (possibly second part) (EC 2.1.1.-),highly similar to C-terminus of several methyltransferases e.g. AAF87203.1|AF216282 sarcosine-dimethylglycine methyltransferase from Halorhodospira halochloris (279 aa). Possibly continuation of Rv0520 but we can find no frameshift to account for this. Q7U1V2 No intermediary metabolism and respiration Rv0521 NC_002945.3 Mycobrowser_v2 CDS 614188 615492 . + 0 Mb0535 gabP PROBABLE GABA PERMEASE GABP (4-AMINO BUTYRATE TRANSPORT CARRIER) (GAMA-AMINOBUTYRATE PERMEASE) Mb0535, gabP, len: 434 aa. Equivalent to Rv0522,len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 434 aa overlap). Probable gabP, GABA permease (gamma-aminobutyrate permease), integral membrane protein, highly similar to others e.g. GABP_ECOLI|P25527 gaba permease from Escherichia coli (466 aa), FASTA scores: opt: 1218, E(): 0, (44.3% identity in 424 aa overlap); etc. Also similar to other Mycobacterium tuberculosis permeases e.g. MTCY13E10.06c FASTA score: (34.4% identity in 407 aa overlap). Contains PS00218 Amino acid permeases signature. Overlaps and extends Rv0523c|MTCY25D10.01 from overlapping cosmid. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Q7U1V1 No cell wall and cell processes Rv0522 NC_002945.3 Mycobrowser_v2 CDS 615476 615871 . - 0 Mb0536c conserved protein Mb0536c, -, len: 131 aa. Equivalent to Rv0523c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing some similarity to M. tuberculosis proteins Rv1598c|MTCY336.06; and Rv1871c|MTCY336_06|O06592 (136 aa), FASTA scores: opt: 197, E(): 5e-08, (38.4% identity in 99 aa overlap). Q7U1V0 No conserved hypotheticals Rv0523c NC_002945.3 Mycobrowser_v2 CDS 615985 617373 . + 0 Mb0537 hemL PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) Mb0537, hemL, len: 462 aa. Equivalent to Rv0524,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Probable hemL,glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8),equivalent to P46716|GSA_MYCLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE from Mycobacterium leprae (446 aa), FASTA scores: opt: 1532, E(): 0, (82.6% identity in 460 aa overlap). Also highly similar to others e.g. Q9F2S0|GSA_STRCO from Streptomyces coelicolor (438 aa); Q06774|GSA_PROFR from Propionibacterium freudenreichii (441 aa); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BFC4,P63507 No intermediary metabolism and respiration Rv0524 NC_002945.3 Mycobrowser_v2 CDS 898911 899540 . + 0 Mb0827 CONSERVED HYPOTHETICAL PROTEIN Mb0827, -, len: 209 aa. Equivalent to Rv0804, len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Conserved hypothetical protein, showing similarity with C-terminus of Rv1863c|MTCY359.10 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 199, E(): 1.2e-05, (33.2% identity in 220 aa overlap); and Rv0658c. Contains PS01151 Fimbrial biogenesis outer membrane usher protein signature. Q7U186 No conserved hypotheticals Rv0804 NC_002945.3 Mycobrowser_v2 CDS 617373 617981 . + 0 Mb0538 conserved protein Mb0538, -, len: 202 aa. Equivalent to Rv0525, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein, equivalent to Q49821|B2168_C3_276|S72912 hypothetical protein from Mycobacterium leprae (202 aa), FASTA scores: opt: 1151,E(): 0, (82.5% identity in 200 aa overlap). Also highly similar to CAC08377.1|AL392176 putative phosphoglycerate mutase from Streptomyces coelicolor (233 aa); and similar to SLL0395|Q55734 hypothetical 23.8 kDa protein from SYNECHOCYSTIS SP. (212 aa), FASTA scores: opt: 207, E(): 5.1e-07, (28.2% identity in 195 aa overlap). Also some similarity to Rv2228c|Y019_MYCTU|Q10512|cy427.09 hypothetical 39.2 kd protein from Mycobacterium tuberculosis (364 aa), FASTA scores: opt: 236, E(): 1.1e-08, (34.3% identity in 198 aa overlap). Q7U1U9 No conserved hypotheticals Rv0525 NC_002945.3 Mycobrowser_v2 CDS 618643 619422 . + 0 Mb0540 ccdA POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCDA Mb0540, ccdA, len: 259 aa. Equivalent to Rv0527,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Possible ccdA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to Q49810|B2168_C1_192|S72890 hypothetical protein from Mycobacterium leprae (262 aa),FASTA scores: opt: 1341, E(): 0, (79.0% identity in 262 aa overlap). Also highly similar to others e.g. CAC08380.1 (253 aa); CCDA_BACSU|P45706 cytochrome C-type biogenesis protein from Bacillus subtilis (235 aa), FASTA scores: opt: 307, E(): 7.4e-13, (30.4% identity in 237 aa overlap); etc. SEEMS TO BELONG TO THE DSBD SUBFAMILY. Note that previously known as ccsA. Q7U1U7 No intermediary metabolism and respiration Rv0527 NC_002945.3 Mycobrowser_v2 CDS 619455 621044 . + 0 Mb0541 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0541, -, len: 529 aa. Equivalent to Rv0528, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 529 aa overlap). Probable conserved transmembrane protein, equivalent (shorter 14 aa in N-terminus) to CAC31926.1|AL583925 conserved membrane protein from Mycobacterium leprae (542 aa). Also highly similar to Q49817|B2168_C2_237|S72902 hypothetical protein from Mycobacterium leprae (364 aa), FASTA scores: opt: 1846, E(): 0, (81.1% identity in 338 aa overlap); and Q49811|B2168_C1_194|S72891 hypothetical protein from Mycobacterium leprae (106 aa), FASTA scores: opt: 506,E(): 3.8e-26, (73.6% identity in 106 aa overlap). Also highly similar to CAC08381.1|AL392176 putative integral membrane protein from Streptomyces coelicolor (574 aa). Q7U1U6 No cell wall and cell processes Rv0528 NC_002945.3 Mycobrowser_v2 CDS 623943 625688 . + 0 Mb0545 PE_PGRS6a PE-PGRS FAMILY PROTEIN [FIRST PART] Mb0545, PE_PGRS6a, len: 581 aa. Equivalent to 5' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (92.7% identity in 564 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts,PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a. Q7U1U2 No NC_002945.3 Mycobrowser_v2 CDS 625594 625821 . + 0 Mb0546 PE_PGRS6b PE-PGRS FAMILY PROTEIN [SECOND PART] Mb0546, PE_PGRS6b, len: 75 aa. Equivalent to 3' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b. No NC_002945.3 Mycobrowser_v2 CDS 736753 737460 . + 0 Mb0660 rplA 50s ribosomal protein l1 rpla Mb0660, rplA, len: 235 aa. Equivalent to Rv0641,len: 235 aa, from Mycobacterium tuberculosis strain H37Rv (99.6% identity in 235 aa overlap). Probable rplA, 50S ribosomal protein L1, equivalent to NP_302281.1|NC_002677 50S ribosomal protein L1 from Mycobacterium leprae (235 aa). Also highly similar to others e.g. P3625|RL1_STRGR 50s ribosomal protein L1 from Streptomyces griseus (240 aa), FASTA scores: opt: 1081, E(): 0, (72.2% identity in 230 aa overlap); etc. BELONGS TO THE L1P FAMILY OF RIBOSOMAL PROTEINS. X2BFN1,P59790 No information pathways Rv0641 NC_002945.3 Mycobrowser_v2 CDS 625717 626724 . - 0 Mb0547c fabH 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III FABH (BETA-KETOACYL-ACP SYNTHASE III) (KAS III) Mb0547c, fabH, len: 335 aa. Equivalent to Rv0533c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). fabH (alternate gene name: mtFabH), 3-oxoacyl-[acyl-carrier protein] synthase III (EC 2.3.1.41) (see citations below), highly similar to others e.g. Q54206|FABH from STREPTOMYCES GLAUCESCENS (333 aa), FASTA scores: opt: 1109, E(): 0, (51.4% identity in 333 aa overlap); FABH_ECOLI|P24249 3-oxoacyl-[acyl-carrier-protein] synthase III (317 aa),FASTA scores: opt: 666, E(): 0, (37.1% identity in 318 aa overlap); etc. BELONGS TO THE FABH FAMILY. Note that previously known as fabH. X2BF69,P0A575 No NC_002945.3 Mycobrowser_v2 CDS 626806 627684 . - 0 Mb0548c menA 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE MENA (DHNA-OCTAPRENYLTRANSFERASE) Mb0548c, menA, len: 292 aa. Equivalent to Rv0534c,len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Probable menA,1,4-dihydroxy-2-naphthoate octaprenyltransferase (EC 2.5.1.-), integral membrane protein, equivalent to Y13803|MLB1306_2|NP_302556.1 probable 4-dihydroxy-2-naphthoate octaprenyltransferase from Mycobacterium leprae (294 aa), FASTA scores: opt: 1509,E(): 0, (80.2% identity in 288 aa overlap). Also highly similar to others e.g. MENA_ECOLI|P32166|B3930 from Escherichia coli (308 aa), FASTA scores: opt: 495, E(): 2.9e-25, (36.3 identity in 289 aa overlap); etc. BELONGS TO THE MENA FAMILY. X2BFB9,P65651 No NC_002945.3 Mycobrowser_v2 CDS 652022 652747 . - 0 Mb0575c POSSIBLE BENZOQUINONE METHYLTRANSFERASE (METHYLASE) Mb0575c, -, len: 241 aa. Equivalent to Rv0560c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Possible benzoquinone methyltransferase (EC 2.1.1.-) (see citation below),similar to other hypothetical proteins and methyltransferases e.g. Q54300 METHYLTRANSFERASE (211 aa),FASTA scores: opt: 203, E(): 4.8e-07, (30.9% identity in 136 aa overlap). Similar to Rv3699, Rv1377c, Rv2675c, etc from Mycobacterium tuberculosis. Rv0560c can be induced by salicylate and para-amino-salicylate (PAS). Q7U1S0 No intermediary metabolism and respiration Rv0560c NC_002945.3 Mycobrowser_v2 CDS 627701 628495 . + 0 Mb0549 pnp PROBABLE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE PNP (MTA PHOSPHORYLASE) Mb0549, pnp, len: 264 aa. Equivalent to Rv0535,len: 264 aa, from Mycobacterium tuberculosis strain H37R,(100.0% identity in 264 aa overlap). Probable pnp,5'-methylthioadenosine phosphorylase (EC 2.4.2.28), highly similar to others e.g. CAB90972.1|AL355832 putative methylthioadenosine phosphorylase from Streptomyces coelicolor (280 aa); etc. Also similar to Rv3307|deoD PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE (EC 2.4.2.1) from Mycobacterium tuberculosis (268 aa). BELONGS TO THE PNP/MTAP FAMILY 2 OF PHOSPHORYLASES. Gene name could be inappropriate. Q7U1U1 No intermediary metabolism and respiration Rv0535 NC_002945.3 Mycobrowser_v2 CDS 754753 755136 . - 0 Mb0675c vapc6 possible toxin vapc6 Mb0675c, -, len: 127 aa. Equivalent to Rv0656c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Conserved hypothetical protein, showing similarity with proteins from Mycobacterium tuberculosis e.g. Rv2757c, Rv2546,etc. Q7U1J1 No virulence, detoxification, adaptation Rv0656c NC_002945.3 Mycobrowser_v2 CDS 628492 629532 . + 0 Mb0550 galE3 PROBABLE UDP-GLUCOSE 4-EPIMERASE GALE3 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE) Mb0550, galE3, len: 346 aa. Equivalent to Rv0536,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Possible galE3,UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar to CAB76986.1|AL159178 putative epimerase from Streptomyces coelicolor (334 aa); and similar to other epimerases e.g. NP_436775.1|NC_003078 putative NDP-glucose dehydrataseepimerase protein from Sinorhizobium meliloti (368 aa); AF143772|AF143772_7 GepiA from Mycobacterium avium strain 2151 (353 aa), FASTA scores: opt: 577, E(): 3.9e-29, (36.6% identity in 352 aa overlap); GALE_METJA|Q57664 putative UDP-glucose 4-epimerase (305 aa), FASTA scores: opt: 300, E(): 1.6e-12, (30.9% identity in 343 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3634c, Rv3784, etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY. Note that previously known as galE2. Q7U1U0 No NC_002945.3 Mycobrowser_v2 CDS 629542 630975 . - 0 Mb0551c PROBABLE INTEGRAL MEMBRANE PROTEIN Mb0551c, -, len: 477 aa. Equivalent to Rv0537c,len: 477 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 477 aa overlap). Probable integral membrane protein, showing weak similarity to YDNK_STRCO|P40180 hypothetical 41.2 kd protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 122,E(): 0.85, (28.2% identity in 373 aa overlap). Q7U1T9 No cell wall and cell processes Rv0537c NC_002945.3 Mycobrowser_v2 CDS 631284 632930 . + 0 Mb0552 POSSIBLE CONSERVED MEMBRANE PROTEIN Mb0552, -, len: 548 aa. Equivalent to Rv0538, len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Possible conserved membrane protein. Middle region highly similar to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein from Mycobacterium bovis (295 aa) possible transmembrane protein with a repetitive proline, threonine-rich region at C-terminus. Q7U1T8 No cell wall and cell processes Rv0538 NC_002945.3 Mycobrowser_v2 CDS 632987 633619 . + 0 Mb0553 PROBABLE DOLICHYL-PHOSPHATE SUGAR SYNTHASE (DOLICHOL-PHOSPHATE SUGAR SYNTHETASE) (DOLICHOL-PHOSPHATE SUGAR TRANSFERASE) (SUGAR PHOSPHORYLDOLICHOL SYNTHASE) Mb0553, -, len: 210 aa. Equivalent to Rv0539, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Probable dolichol-P-sugar synthase (EC 2.4.1.-), highly similar to CAB76989.1|AL159178 putative glycosyltransferase from Streptomyces coelicolor (242 aa), and similar to various dolichol-P-sugar synthetases and sugar transferases e.g. NP_126257.1|NC_000868 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED PROTEIN from Pyrococcus abyssi (211 aa); N-terminus of NP_127133.1|NC_000868 DOLICHOL-P-GLUCOSE SYNTHETASE from Pyrococcus abyssi (378 aa); N-terminus of NP_068880.1|NC_000917 putative dolichol-P-glucose synthetase from Archaeoglobus fulgidus (369 aa), FASTA scores: E(): 2.4e-13, (32. 1% identity in 193 aa overlap); Q26732 DOLICHYL-PHOSPHATE-MANNOSE SYNTHASE PRECURSOR from TRYPANOSOMA BRUCEI (267 aa), FASTA scores: opt: 179, E(): 0.0011, (30.7% identity in 205 aa overlap); etc. Also similar to Rv2051c|MTY25D10_18 from Mycobacterium tuberculosis. Contains S00017 ATP/GTP-binding site motif A (P-loop). X2BFC3,P0A598 No intermediary metabolism and respiration Rv0539 NC_002945.3 Mycobrowser_v2 CDS 633616 634278 . + 0 Mb0554 CONSERVED HYPOTHETICAL PROTEIN Mb0554, -, len: 220 aa. Equivalent to Rv0540, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Streptomyces coelicolor: CAB76990.1|AL159178 (213 aa); N-terminus of BAA84086.1|AB032065 (446 aa); and CAB61872.1|AL133252|SCE46_21 (210 aa), FASTA scores: opt: 267, E(): 5.3e-10, (32.7% identity in 202 aa overlap). Also some similarity with D90913_63|PCC6803 from Synecho cystis sp (211 aa), FASTA scores: opt: 189, E(): 4.7e-06,(25.3 identity in 194 aa overlap). Q7U1T7 No conserved hypotheticals Rv0540 NC_002945.3 Mycobrowser_v2 CDS 634299 635648 . - 0 Mb0555c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0555c, -, len: 449 aa. Equivalent to Rv0541c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 449 aa overlap). Probable conserved integral membrane protein, highly similar (except first 40 residues) to CAB76994.1|AL159178 putative integral membrane protein from Streptomyces coelicolor (456 aa). Also some similarity to Q13724|GCS1_HUMAN MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (834 aa), FASTA scores: opt: 150, E(): 0.013, (27.1% identity in 339 aa overlap). Contains PS00041 Bacterial regulatory proteins,araC family signature. Q7U1T6 No cell wall and cell processes Rv0541c NC_002945.3 Mycobrowser_v2 CDS 635660 636748 . - 0 Mb0556c menE POSSIBLE O-SUCCINYLBENZOIC ACID--COA LIGASE MENE (OSB-COA SYNTHETASE) (O-SUCCINYLBENZOATE-COA SYNTHASE) Mb0556c, menE, len: 362 aa. Equivalent to Rv0542c,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 362 aa overlap). Possible menE,O-succinylbenzoic acid-CoA ligase (EC 6.2.1.26), highly similar to Q50170|AAA63145.1|U15187|XCLB 4-Coumarate--CoA ligase from Mycobacterium leprae (352 aa), FASTA scores: opt: 1815, E(): 0, (78.9% identity in 351 aa overlap). Also similar to N-terminus of acid-CoA ligases e.g. NP_471116.1|NC_003212 O-succinylbenzoic acid-CoA ligase from Listeria innocua (469 aa); NP_390957.1|NC_000964 O-succinylbenzoic acid-CoA ligase from Bacillus subtilis (486 aa); MENE_HAEIN|P44565 O-succinylbenzoic acid-CoA ligase from Haemophilus influenzae (452 aa), FASTA scores: opt: 307, E(): 4.6e-12, (25.4% identity in 339 aa overlap); etc. Also some similarity with fadD proteins from Mycobacterium tuberculosis. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U1T5 No NC_002945.3 Mycobrowser_v2 CDS 637179 637457 . - 0 Mb0558c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0558c, -, len: 92 aa. Equivalent to Rv0544c, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Possible conserved transmembrane protein, equivalent to NP_302470.1|NC_002677 possible membrane protein from Mycobacterium leprae (96 aa); and shows some similarity to MLU15187_33|Q50172|U296V from Mycobacterium leprae (36 aa), FASTA scores: opt: 151,E(): 2.1e-05, (71.4% identity in 35 aa overlap). Also some similarity with VATL_NEPNO|Q26250 vacuolar ATP synthase 16 kd proteolipid from Nephrops norvegicus (159 aa), FASTA scores: opt: 80, E(): 11, (26.1% identity in 88 aa overlap). Q7U1T3 No cell wall and cell processes Rv0544c NC_002945.3 Mycobrowser_v2 CDS 637454 638707 . - 0 Mb0559c pitA PROBABLE LOW-AFFINITY INORGANIC PHOSPHATE TRANSPORTER INTEGRAL MEMBRANE PROTEIN PITA Mb0559c, pitA, len: 417 aa. Equivalent to Rv0545c,len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 417 aa overlap). Probable pitA,low-affinity inorganic phosphate transporter, integral membrane protein, equivalent to Q50173|NP_302471.1 pitA from Mycobacterium leprae (414 aa), FASTA scores: opt: 2035, E(): 0, (76.3% identity in 418 aa overlap). Also highly similar to others e.g. CAB59461.1|AL132644 putative low-affinity phosphate transport protein from Streptomyces coelicolor (423 aa); PITA_ECOLI|P37308 low-affinity inorganic phosphate transporter from Escherichia coli (499 aa), FASTA scores: opt: 304, E(): 6.9e-10, (32.5 % identity in 234 aa overlap); etc. BELONGS TO THE PHO-4 FAMILY OF TRANSPORTERS, PIT SUBFAMILY. X2BFE2,P59950 No NC_002945.3 Mycobrowser_v2 CDS 649779 650915 . + 0 Mb0572 mgta mannosyltransferase mgta Mb0572, pimB, len: 378 aa. Equivalent to Rv0557,len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). pimB (alternate gene name: mtfB), mannosyltransferase (EC 2.4.1.-) (see citation below), similar to other various transferases e.g. NP_243554.1|NC_002570 alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans (381 aa); NP_249533.1|NC_002516 probable glycosyl transferase from Pseudomonas aeruginosa (406 aa); NP_419573.1|NC_002696 glycosyl transferase, group 1 family protein, from Caulobacter crescentus (455 aa); etc. Also similar to Q55598 hypothetical 44.9 kDa protein from SYNECHOCYSTIS SP (409 aa), FASTA scores: opt: 703, E(): 0,(33.9% identity in 378 aa overlap); GPI3_YEAST|P32363 n-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (452 aa), FASTA scores: opt: 230, E(): 1.1e-07,(23.5% identity in 328 aa overlap). Q7U1S2 No lipid metabolism Rv0557 NC_002945.3 Mycobrowser_v2 CDS 638827 639213 . - 0 Mb0560c conserved protein Mb0560c, -, len: 128 aa. Equivalent to Rv0546c,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, equivalent to AAA63111.1|U15187|Q50174|U296X hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 748,E(): 0, (84.2% identity in 133 aa overlap). Also highly similar to CAB95979.1|AL360034 conserved hypothetical protein from Streptomyces coelicolor (130 aa); and similar to AE000854_8|O26852 S-D-LACTOYLGLUTATHIONE METHYLGLYOXAL LYASE from Methanobacterium thermoautotropto (116 aa),FASTA scores: opt: 155, E(): 0.00019, (30.6% identity in 108 aa overlap); YAER_ECOLI hypothetical 14.7 kd protein from Escherichia coli (129 aa), FASTA scores: opt: 104,E(): 0.42, (28.7% identity in 115 aa overlap). Also similar to Rv2068c from Mycobacterium tuberculosis. Q7U1T2 No conserved hypotheticals Rv0546c NC_002945.3 Mycobrowser_v2 CDS 639276 640160 . - 0 Mb0561c POSSIBLE OXIDOREDUCTASE Mb0561c, -, len: 294 aa. Equivalent to Rv0547c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases e.g. fatty acyl-CoA reductase from Acinetobacter calcoaceticus (295 aa); NP_280196.1|NC_002607 3-oxoacyl-[acyl-carrier-protein] reductase from Halobacterium sp. NRC-1 (255 aa); NP_349214.1|NC_003030 Short-chain alcohol dehydrogenase family protein from Clostridium acetobutylicum (255 aa); etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Y04M_MYCTU|Q10783 putative oxidoreductase (341 aa), FASTA scores: opt: 644, E(): 0,(46.1% identity in 258 aa overlap). Q7U1T1 No intermediary metabolism and respiration Rv0547c NC_002945.3 Mycobrowser_v2 CDS 640256 641200 . - 0 Mb0562c menB naphthoate synthase menb (dihydroxynaphthoic acid synthetase) (dhna synthetase) Mb0562c, menB, len: 314 aa. Equivalent to Rv0548c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable menB,naphthoate synthase (dihydroxynaphthonic acid synthase) (EC 4.1.3.36), equivalent to NP_302473.1|NC_002677 naphthoate synthase from Mycobacterium leprae (300 aa). Also similar to others e.g. MENB_ECOLI|P27290 naphthoate synthase from Escherichia coli (285 aa), FASTA scores: opt: 599, E(): 9.3e-33, (48.1 identity in 285 aa overlap); etc. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Q7U1T0 No NC_002945.3 Mycobrowser_v2 CDS 641472 641609 . - 0 Mb0563c vapc3 CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb0563c, -, len: 45 aa. Similar to 3' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 45 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065,and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c. No NC_002945.3 Mycobrowser_v2 CDS 693129 693272 . + 0 Mb0608 mce2Db MCE-FAMILY PROTEIN MCE2DB [SECOND PART] Mb0608, mce2Db, len: 47 aa. Equivalent to 3' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (95.7% identity in 47 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db. No NC_002945.3 Mycobrowser_v2 CDS 642339 644054 . - 0 Mb0566c fadD8 PROBABLE FATTY-ACID-COA LIGASE FADD8 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0566c, fadD8, len: 571 aa. Equivalent to Rv0551c,len: 571 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 571 aa overlap). Probable fadD8,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 585, E(): 9.5e-30, (28.7% identity in 536 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Note other possible start sites exist downstream of this start. Q7U1S7 No NC_002945.3 Mycobrowser_v2 CDS 644132 645736 . + 0 Mb0567 conserved protein Mb0567, -, len: 534 aa. Equivalent to Rv0552, len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 534 aa overlap). Conserved hypothetical protein, similar to others from several organisms. Also shows some similarity with regulatory proteins e.g. AEPA_ERWCA|Q06555 exoenzymes regulatory protein aepA [Precursor] from Erwinia carotovora (465 aa),FASTA scores: opt: 278, E(): 7.6e-11, (23.0% identity in 408 aa overlap). Also similar to Z99119|BSUB0016_28 from Bacillus subtilis (529 aa), FASTA scores: opt: 436, E(): 8.3e-20, (23.8% identity in 547 aa overlap). C-terminus is similar to MLRRNOPR_1 HYPOTHETICAL 17.7 KD PROTEIN from Mycobacterium leprae (154 aa), FASTA score: (43.1% identity in 160 aa overlap). Q7U1S6 No conserved hypotheticals Rv0552 NC_002945.3 Mycobrowser_v2 CDS 645733 646713 . + 0 Mb0568 menC PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE) Mb0568, menC, len: 326 aa. Equivalent to Rv0553,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 326 aa overlap). Probable menC,muconate cycloisomerase (EC 5.5.1.1), equivalent to NP_302476.1|NC_002677 putative isomerase/racemase from Mycobacterium leprae (334 aa). Also similar to other muconate cycloisomerases e.g. TCBD_PSESP|P27099 chloromuconate cycloisomerase (370 aa), FASTA scores: opt: 249, E(): 7.8e-09, (32.7% identity in 199 aa overlap). Also similar to O-succinylbenzoate-CoA synthases. BELONGS TO THE MANDELATE RACEMASE / MUCONATE LACTONIZING ENZYME FAMILY. X2BFD4,P65426 No intermediary metabolism and respiration Rv0553 NC_002945.3 Mycobrowser_v2 CDS 646710 647498 . + 0 Mb0569 bpoC POSSIBLE PEROXIDASE BPOC (NON-HAEM PEROXIDASE) Mb0569, bpoC, len: 262 aa. Equivalent to Rv0554,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Possible bpoC,peroxidase (non-haem peroxidase) (EC 1.11.1.-), equivalent to NP_302477.1|NC_002677 putative hydrolase from Mycobacterium leprae (265 aa). Also highly similar or similar to various hydrolases and peroxidases e.g. CAB38877.1|AL035707|T36181 probable hydrolase from Streptomyces coelicolor (272 aa); CAC48368.1|Y16952 putative hydrolase from Amycolatopsis mediterranei (284 aa); P29715|BPA2_STRAU non-haem bromoperoxidase bpo-a2 (bromide peroxidase) (EC 1.11.1.-) from Streptomyces aureofaciens (277 aa), FASTA scores: opt: 325, E(): 2.3e-15, (29.5% identity in 268 aa overlap); O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase (chloride peroxidase) (EC 1.11.1.10) from Streptomyces aureofaciens (278 aa); etc. Also similar to M. tuberculosis non-heme haloperoxidases and epoxide hydrolases e.g. Rv1938, Rv3617, etc. Q7U1S5 No virulence, detoxification, adaptation Rv0554 NC_002945.3 Mycobrowser_v2 CDS 650932 651636 . + 0 Mb0573 menH PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase) Mb0573, menH, len: 234 aa. Equivalent to Rv0558,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable menH (alternate gene name: menG), ubiquinone/menaquinone biosynthesis methlytransferase (2-heptaprenyl-1,4-naphthoquinone methyltransferase) (EC 2.1.1.-), equivalent to NP_302480.1|NC_002677 putative ubiquinone/menaquinone biosynthesis methyltransferase from Mycobacterium leprae (238 aa). Also highly similar to others e.g. CAB44537.1|AL078618|T34630 from Streptomyces coelicolor (231 aa); UBIE_ECOLI|P27851 from Escherichia coli strain K12 (251 aa), FASTA scores: opt: 421, E(): 1.2e-21, (43.2% identity in 227 aa overlap); GRC2_BACSU|P31113 from Bacillus subtilis (233 aa), FASTA scores: opt: 345, E(): 1.4e-16, (34.6% identity in 231 aa overlap); etc. BELONGS TO THE UBIE FAMILY. Note that previously known as ubiE. X2BFD8,P0A639 No intermediary metabolism and respiration Rv0558 NC_002945.3 Mycobrowser_v2 CDS 651650 651988 . - 0 Mb0574c POSSIBLE CONSERVED SECRETED PROTEIN Mb0574c, -, len: 112 aa. Equivalent to Rv0559c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Possible conserved secreted protein, similar to NP_302481.1|NC_002677 putative secreted protein from Mycobacterium leprae (112 aa). Also similar to Y08B_MYCTU|Q11048 hypothetical 11.6 kd protein FASTA scores: opt: 111, E(): 011, (25.4% identity in 114 aa overlap). Contains possible N-terminal signal sequence. Q7U1S1 No cell wall and cell processes Rv0559c NC_002945.3 Mycobrowser_v2 CDS 760301 760573 . + 0 Mb0683 vapb8 possible antitoxin vapb8 Mb0683, -, len: 90 aa. Equivalent to Rv0664, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein. Q7U1I3 No virulence, detoxification, adaptation Rv0664 NC_002945.3 Mycobrowser_v2 CDS 652772 653998 . - 0 Mb0576c POSSIBLE OXIDOREDUCTASE Mb0576c, -, len: 408 aa. Equivalent to Rv0561c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar (except in first 30 aa) to NP_302482.1|NC_002677 putative FAD-linked oxidoreductase from Mycobacterium leprae (408 aa). Also similar to T34627 probable electron transfer oxidoreductase from Streptomyces coelicolor (430 aa); and some bacteriochlorophyll synthases e.g. NP_069300.1|NC_000917 bacteriochlorophyll synthase from Archaeoglobus fulgidus (410 aa); Q55087 GERANYLGERANYL HYDROGENASE (407 aa), FASTA scores: opt: 208, E(): 1.7e-06, (26.9% identity in 327 aa overlap). Q7U1R9 No intermediary metabolism and respiration Rv0561c NC_002945.3 Mycobrowser_v2 CDS 654014 655021 . + 0 Mb0577 grcC1 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) Mb0577, grcC1, len: 335 aa. Equivalent to Rv0562,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Probable grcC1,polyprenyl diphosphate synthetase (EC 2.5.1.-), equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (325 aa); Rv3383c,Rv3398c, etc. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY. Q7U1R8 No NC_002945.3 Mycobrowser_v2 CDS 705997 707154 . - 0 Mb0627c HYPOTHETICAL PROTEIN Mb0627c, -, len: 385 aa. Equivalent to Rv0610c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 385 aa overlap). Hypothetical unknown protein. Q7U1M6 No conserved hypotheticals Rv0610c NC_002945.3 Mycobrowser_v2 CDS 655122 655982 . + 0 Mb0578 htpX PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX Mb0578, htpX, len: 286 aa. Equivalent to Rv0563,len: 286 aa (alternative start at position 654006), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 286 aa overlap). Probable htpX, protease heat shock protein X (EC 3.4.24.-) (transmembrane protein),equivalent to NP_302484.1|NC_002677 putative peptidase from Mycobacterium leprae (287 aa). Also highly similar to others e.g. CAC08262.1|AL392146 putative peptidase from Streptomyces coelicolor (287 aa); NP_387431.1|NC_003047 PUTATIVE PROTEASE TRANSMEMBRANE PROTEIN from Sinorhizobium meliloti (319 aa); NP_105051.1|NC_002678 heat shock protein (htpX) from Mesorhizobium loti (336 aa); NP_248692.1|NC_000909|U67608|MJU67608_8 heat shock protein HtpX, possibly protease (htpX) from Methanococcus jannaschii (284 aa), FASTA scores: opt: 660, E(): 0, (46.5 identity in 245 aa overlap). Continuation of MTCY25D10.42. TBparse score is 0.887. BELONGS TO PEPTIDASE FAMILY M48 (ZINC METALLOPROTEASE). COFACTOR: Zinc. X2BFE3,P65816 No virulence, detoxification, adaptation Rv0563 NC_002945.3 Mycobrowser_v2 CDS 656167 657192 . - 0 Mb0579c gpdA1 PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA1 (NAD(P)H-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) (NAD(P)H-DEPENDENT DIHYDROXYACETONE-PHOSPHATE REDUCTASE) Mb0579c, gpdA1, len: 341 aa. Equivalent to Rv0564c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 341 aa overlap). Possible gpdA1(alternate gene names: gpsA, glyC),glycerol-3-phosphate dehydrogenase [NAD(P)+] dependant (EC 1.1.1.94), similar to many other glycerol-3-phosphate dehydrogenases e.g. P46919|GPDA_BACSU from Bacillus subtilis (345 aa), FASTA scores: opt: 731, E(): 0, (37.3% identity in 332 aa overlap); etc. Also similar to Rv2982c|gpdA2|MTCY349.05|Z83018|MTCY349_5 from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 740, E(): 0, (40.4% identity in 322 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY. X2BFG8,P64189 No NC_002945.3 Mycobrowser_v2 CDS 760570 760908 . + 0 Mb0684 vapc8 possible toxin vapc8 Mb0684, -, len: 112 aa. Equivalent to Rv0665, len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Conserved hypothetical protein, similar to Rv0627 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), and showing similarity with Rv0595c. Q7U1I2 No virulence, detoxification, adaptation Rv0665 NC_002945.3 Mycobrowser_v2 CDS 657253 658713 . - 0 Mb0580c PROBABLE MONOOXYGENASE Mb0580c, -, len: 486 aa. Equivalent to Rv0565c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 486 aa overlap). Probable monoxygenase (EC 1.14.-.-), highly similar to NP_301173.1|NC_002677 putative monooxygenase from Mycobacterium leprae (494 aa). Also highly similar to others e.g. NP_421371.1|NC_002696 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa); C-terminus of NP_051574.1|NC_000958 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa); P12015|CYMO_ACISP CYCLOHEXANONE MONOOXYGENASE (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: opt: 354, E(): 2.1e-16, (23.7% identity in 435 aa overlap); etc. Also similar to other putative monoxygenases from Mycobacterium tuberculosis e.g. Rv3854c (489 aa), MTCY01A6.14 (489 aa), MTV013_4 (495 aa),MTCY31.20 (495 aa). Q7U1R7 No intermediary metabolism and respiration Rv0565c NC_002945.3 Mycobrowser_v2 CDS 658791 659282 . - 0 Mb0581c conserved protein Mb0581c, -, len: 163 aa. Equivalent to Rv0566c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to others e.g. P77482|YAJQ_ECOLI HYPOTHETICAL 19.0 KDa PROTEIN from Escherichia coli (169 aa), FASTA scores: opt: 422, E(): 5.4e-20, (44.1 identity in 161 aa overlap); etc. X2BFI9 No conserved hypotheticals Rv0566c NC_002945.3 Mycobrowser_v2 tRNA 659352 659432 . + 0 tyrT tyrT tRNA-Tyr tyrT, len: 81 nt. Equivalent to tyrT, len: 81 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 81 nt overlap). tRNA-Tyr, anticodon gta,length = 81 No NC_002945.3 Mycobrowser_v2 CDS 659564 660583 . + 0 Mb0582 PROBABLE METHYLTRANSFERASE/METHYLASE Mb0582, -, len: 339 aa. Equivalent to Rv0567, len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 339 aa overlap). Probable methyltransferase (EC 2.1.1.-), similar to several e.g. P39896|TCMO_STRGA TETRACENOMYCIN POLYKETIDE SYNTHESIS 8-O-METHYLTRANSFERASE from Streptomyces glaucescens (339 aa), FASTA scores: opt: 685, E(): 0, (35.8% identity in 335 aa overlap); P10950|HIOM_BOVIN HYDROXYINDOLE O-METHYLTRANSFERASE (EC 2.1.1.4) from Bos taurus (345 aa),FASTA scores: opt: 509, E(): 3.4e-27, (30.7% identity in 332 aa overlap) etc. Q7U1R6 No intermediary metabolism and respiration Rv0567 NC_002945.3 Mycobrowser_v2 CDS 683128 685515 . - 0 Mb0600c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0600c, -, len: 795 aa. Equivalent to Rv0585c,len: 795 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 795 aa overlap). Probable conserved integral membrane protein. C-terminus similar to CAB88984.1|AL353864 putative integral membrane protein from Streptomyces coelicolor (299 aa); and C-terminal region of CAC01311.1|AL390968 putative integral membrane protein from Streptomyces coelicolor (925 aa). Also some similarity with Rv0204 from Mycobacterium tuberculosis. Q7U1Q0 No cell wall and cell processes Rv0585c NC_002945.3 Mycobrowser_v2 CDS 704731 705132 . + 0 Mb0625 vapc28 possible toxin vapc28. contains pin domain. Mb0625, -, len: 133 aa. Equivalent to Rv0609, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to several Mycobacterium tuberculosis hypothetical proteins e.g. YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37 CONSERVED HYPOTHETICAL PROTEIN (139 aa), FASTA scores: opt: 262,E(): 8.1e-12, (39.1% identity in 128 aa overlap); MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05 CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA score: (42.9% identity in 126 aa overlap), Rv0565c, Rv3854c, etc. X2BFL4,P67239 No virulence, detoxification, adaptation Rv0609 NC_002945.3 Mycobrowser_v2 CDS 660693 662111 . + 0 Mb0583 cyp135B1 POSSIBLE CYTOCHROME P450 135B1 CYP135B1 Mb0583, cyp135B1, len: 472 aa. Equivalent to Rv0568, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 472 aa overlap). Possible cyp135B1, cytochrome P450 (EC 1.14.-.-), similar to putative cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. P29980|CPXN_ANASP PROBABLE CYTOCHROME P450 from Anabaena sp. strain PCC 7120 (459 aa), FASTA scores: opt: 525, E(): 7.2e-27, (31.9% identity in 417 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0327c|NP_214841.1|NC_000962|CYP135A1|MT0342|MTCY63.32c PUTATIVE CYTOCHROME P450 (449 aa), FASTA scores: opt: 1080, E(): 0, (40.5% identity in 444 aa overlap); Rv3685c|NP_218202.1|NC_000962 PUTATIVE CYTOCHROME P450 (476 aa); Rv0136|NP_214650.1|NC_000962 PUTATIVE CYTOCHROME P450 (441 aa); etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). X2BFF0,P63716 No intermediary metabolism and respiration Rv0568 NC_002945.3 Mycobrowser_v2 CDS 662246 662512 . + 0 Mb0584 conserved protein Mb0584, -, len: 88 aa. Equivalent to Rv0569, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Conserved hypothetical protein. C-terminus highly similar to AAA63065.1|U15184|MLU15184_10 hypothetical protein from Mycobacterium leprae (53 aa), FASTA scores: opt: 140, E(): 0.0046, (64.7% identity in 34 aa overlap). Also similar to T36824|SCI35.11 hypothetical protein from Streptomyces coelicolor (64 aa); and N-terminus of T36956 probable DNA-binding protein from Streptomyces coelicolor (323 aa). Also highly similar to Rv2302|MTCY339.07c|NP_216818.1|NC_000962 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (80 aa), FASTA scores: opt: 300, E(): 1.4e-13, (61.8% identity in 76 aa overlap). Q7U1R5 No conserved hypotheticals Rv0569 NC_002945.3 Mycobrowser_v2 CDS 662538 664670 . + 0 Mb0585 nrdZ PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (LARGE SUBUNIT) NRDZ (RIBONUCLEOTIDE REDUCTASE) Mb0585, nrdZ, len: 710 aa. Equivalent to 5' end of Rv0570, len: 692 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 631 aa overlap). Probable nrdZ, ribonucleoside-diphosphate reductase, large subunit (EC 1.17.4.-), highly similar to others e.g. NP_070492.1|NC_000917|NRD|AE000988_11 ribonucleotide reductase from Archaeoglobus fulgidus (752 aa), FASTA scores: opt: 2001, E(): 0, (52.5% identity in 562 aa overlap) (N-terminus shorter); U73619|TAU73619_1|T37459 ribonucleotide reductase from Thermoplasma acidophilum (857 aa), FASTA scores: opt: 1678, E(): 0, (43.7% identity in 723 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE LARGE CHAIN FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U1R4 No NC_002945.3 Mycobrowser_v2 CDS 664729 666060 . - 0 Mb0586c conserved protein Mb0586c, -, len: 443 aa. Equivalent to Rv0571c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 443 aa overlap). Conserved hypothetical protein, highly similar to the products of two adjacent orfs in Mycobacterium leprae: AAA63059.1|U15184|U650S|Q50111 hypothetical protein (258 aa), FASTA scores: opt: 1071, E(): 0, (72.5% identity in 233 aa overlap); and AAA63058.1|U15184|U650T hypothetical protein (86 aa), FASTA scores: opt: 192, E(): 6.4e-06,(70.8% identity in 48 aa overlap). Also similar to others e.g. NP_107072.1|NC_002678 hypothetical protein from Mesorhizobium loti (235 aa); NP_213031.1|NC_000918 hypothetical protein from Aquifex aeolicus (175 aa); etc. And similar to part of hypothetical proteins from Mycobacterium tuberculosis e.g. C-terminus of Rv2143|MTCY270.25c|Z95388|NP_216659.1|NC_000962 (352 aa),FASTA scores: opt: 592, E(): 7e-32, (49.3% identity in 205 aa overlap); N-terminus of Rv2030c|NP_216546.1|NC_000962 (681 aa). Q7U1R3 No conserved hypotheticals Rv0571c NC_002945.3 Mycobrowser_v2 CDS 666284 666625 . - 0 Mb0587c HYPOTHETICAL PROTEIN Mb0587c, -, len: 113 aa. Equivalent to Rv0572c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 113 aa overlap). Hypothetical unknown protein. Q7U1R2 No conserved hypotheticals Rv0572c NC_002945.3 Mycobrowser_v2 CDS 667093 668484 . - 0 Mb0588c pncb2 nicotinic acid phosphoribosyltransferase pncb2 Mb0588c, -, len: 463 aa. Equivalent to Rv0573c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins and some nicotinate phosphoribosyltransferases e.g. NP_213718.1|NC_000918 hypothetical protein from Aquifex aeolicus (426 aa); AL109962|T36953|SCJ1.20 conserved hypothetical protein from Streptomyces coelicolor (438 aa), FASTA scores: opt: 1089, E(): 0, (49.4% identity in 385 aa overlap); P_391053.1|Z99120|BSUB0017_57|NC_000964 protein similar to nicotinate phosphoribosyltransferase from Bacillus subtilis (490 aa), FASTA scores: opt: 955, E():0, (43.5% identity in 356 aa overlap); etc. Also similar to Q10641|Y03F_MYCTU|MTCY130.15c|Rv1330c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (509 aa), FASTA scores: opt: 761, E(): 0, (38.4% identity in 437 aa overlap). Q7U1R1 No intermediary metabolism and respiration Rv0573c NC_002945.3 Mycobrowser_v2 CDS 668494 669636 . - 0 Mb0589c CONSERVED HYPOTHETICAL PROTEIN Mb0589c, -, len: 380 aa. Equivalent to Rv0574c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Conserved hypothetical protein, showing similarity with other hypothetical proteins and polyglutamate synthases (encapsulation proteins) e.g. AAK64444.1|AF377339_5|AF377339 polyglutamate synthase CapA from Myxococcus xanthus (405 aa); M24150|BACCAPABC_3|CapA polyglutamate synthase (encapsulation protein) from B.anthracis (411 aa), FASTA scores: opt: 261, E(): 4.3e-10, (25.8% identity in 287 aa overlap); etc. Q7U1R0 No conserved hypotheticals Rv0574c NC_002945.3 Mycobrowser_v2 CDS 669852 670988 . - 0 Mb0590c POSSIBLE OXIDOREDUCTASE Mb0590c, -, len: 378 aa. Equivalent to 5' end of Rv0575c, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 346 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786,E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 SALICYLATE HYDROXYLASE from SPHINGOMONAS (395 aa), FASTA scores: opt: 267, E():5e-11, (26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U1Q9 No NC_002945.3 Mycobrowser_v2 CDS 671091 672395 . + 0 Mb0591 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY) Mb0591, -, len: 434 aa. Equivalent to Rv0576, len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 434 aa overlap). Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region (~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tuberculosis (107 aa). Contains helix-turn-helix motif at aa 23-43 (Score 1628, +4.73 SD). Q7U1Q8 No regulatory proteins Rv0576 NC_002945.3 Mycobrowser_v2 CDS 760905 761078 . + 0 Mb0685 POSSIBLE MEMBRANE PROTEIN Mb0685, -, len: 57 aa. Equivalent to Rv0666, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Possible membrane protein; has hydrophobic stretch at aa 29-47. Q7U1I1 No cell wall and cell processes Rv0666 NC_002945.3 Mycobrowser_v2 CDS 672409 673194 . + 0 Mb0592 TB27.3 conserved protein tb27.3 Mb0592, TB27.3, len: 261 aa. Equivalent to Rv0577,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). TB27.3, conserved hypothetical protein. Corresponds to O53774|CF30_MYCTU 27 KD ANTIGEN CFP30B from Mycobacterium tuberculosis culture filtrate (260 aa), FASTA scores: opt: 1781, E(): 0,(100.0% identity in 260 aa overlap). Also similar to several hypothetical proteins and hydroxylases from Steptomyces sp. e.g. T35032 probable hydroxylase from Streptomyces coelicolor (263 aa); Q55078 orfA gene product from Streptomyces sp. (275 aa), FASTA scores: E(): 1.5e-1 9, (38.6% identity in 264 aa overlap); D89734_1|P95754 DNA for SgaA SGAA PROTEIN from Streptomyces griseus; and SC9B10_20 from Streptomyces coelicolor (267 aa), FASTA score: (38.9 identity in 252 aa overlap). Also similar to Rv0911|MTCY21C12.05 from Mycobacterium tuberculosis (257 aa), FASTA scores: E(): 1.1e-20, (32.0% identity in 259 aa overlap). X2BFF7 No NC_002945.3 Mycobrowser_v2 CDS 685653 686375 . + 0 Mb0601 mce2r probable transcriptional regulatory protein mce2r (gntr-family) Mb0601, -, len: 240 aa. Equivalent to Rv0586, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable transcriptional regulator, GntR family, similar to many e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase operon regulatory protein from Escherichia coli (258 aa),FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in 232 aa overlap); etc. Also similar to other M. tuberculosis transcriptional regulators GntR proteins e.g. Rv3060c, Rv0792c, etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature and probable helix-turn helix motif from aa 35-56 (Score 1531, +4.40 SD). X2BFB8,P67742 No regulatory proteins Rv0586 NC_002945.3 Mycobrowser_v2 CDS 673239 677159 . - 0 Mb0593c PE_PGRS7 pe-pgrs family protein pe_pgrs7 Mb0593c, PE_PGRS7, len: 1306 aa. Equivalent to Rv0578c, len: 1306 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1306 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many other PGRS proteins e.g. MTCY493.04|Z95844 from M. tuberculosis (1329 aa), FASTA scores: opt: 3994, E(): 0,(54.6% identity in 1375 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures possibly fortuitously. Q7U1Q7 No NC_002945.3 Mycobrowser_v2 CDS 677481 678239 . + 0 Mb0594 CONSERVED HYPOTHETICAL PROTEIN Mb0594, -, len: 252 aa. Equivalent to Rv0579, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Conserved hypothetical protein, showing some similarity to others e.g. AE001747_4 hypothetical protein from Thermotoga maritima (247 aa), FASTA scores: opt: 612, E(): 0, (39.6% identity in 235 aa overlap); AE001004_2 hypothetical protein from Archaeoglobus fulgidus (159 aa), FASTA scores: opt: 196, E(): 1e-06, (28.3% identity in 159 aa overlap); etc. Q7U1Q6 No conserved hypotheticals Rv0579 NC_002945.3 Mycobrowser_v2 CDS 678368 678859 . - 0 Mb0595c conserved protein Mb0595c, -, len: 163 aa. Equivalent to Rv0580c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, equivalent to AAA90989.1|U20446|MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa). TBparse score is 0.910. Q7U1Q5 No conserved hypotheticals Rv0580c NC_002945.3 Mycobrowser_v2 CDS 678953 679168 . + 0 Mb0596 vapb26 possible antitoxin vapb26 Mb0596, -, len: 71 aa. Equivalent to Rv0581, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Conserved hypothetical protein, showing weak similarity to several Mycobacterium tuberculosis proteins including P95003|Z83863|Rv2550c|MTCY159_6 CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA scores: opt: 93, E(): 3.2, (25.7% identity in 70 aa overlap); Rv2871; Rv1241; etc. Also shows weak similarity to X05648|SGSPH_1 from Streptomyces glaucescens (77 aa), FASTA scores: opt: 92, E(): 3.6,(35.4% identity in 65 aa overlap). Q7U1Q4 No virulence, detoxification, adaptation Rv0581 NC_002945.3 Mycobrowser_v2 CDS 679165 679572 . + 0 Mb0597 vapc26 possible toxin vapc26. contains pin domain. Mb0597, -, len: 135 aa. Equivalent to Rv0582, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Hypothetical unknown protein. Q7U1Q3 No virulence, detoxification, adaptation Rv0582 NC_002945.3 Mycobrowser_v2 CDS 679632 680318 . - 0 Mb0598c lpqN PROBABLE CONSERVED LIPOPROTEIN LPQN Mb0598c, lpqN, len: 228 aa. Equivalent to Rv0583c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Probable lpqN,conserved lipoprotein, equivalent to AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein precursor from Mycobacterium kansasii (225 aa), FASTA scores: opt: 945, E(): 0, (62.7% identity in 228 aa overlap); and similar to others from Mycobacteria e.g. Rv0040c and Rv1016c from Mycobacterium tuberculosis. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U1Q2 No NC_002945.3 Mycobrowser_v2 CDS 680472 683105 . + 0 Mb0599 POSSIBLE CONSERVED EXPORTED PROTEIN Mb0599, -, len: 877 aa. Equivalent to Rv0584, len: 877 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 877 aa overlap). Possible conserved exported protein, similar to other hypothetical proteins which are not necessarily secreted e.g. CAB61925.1|AL133278 putative secreted protein from Streptomyces coelicolor (772 aa); AAD51075.1|AF175722_1|AF175722 immunoreactive 89kD antigen PG87 from Porphyromonas gingivalis (781 aa), FASTA scores: opt: 637, E(): 2.1e-30, (29.1% identity in 794 aa overlap); etc. Contains PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. Has potential N-terminal signal peptide. Q7U1Q1 No cell wall and cell processes Rv0584 NC_002945.3 Mycobrowser_v2 CDS 707206 707589 . - 0 Mb0628c HYPOTHETICAL PROTEIN Mb0628c, -, len: 127 aa. Equivalent to Rv0611c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Hypothetical unknown protein. Note that first start has been taken although this overlaps slightly with the upstream ORF. Q7U1M5 No conserved hypotheticals Rv0611c NC_002945.3 Mycobrowser_v2 CDS 686372 687169 . + 0 Mb0602 yrbE2A CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE2A Mb0602, yrbE2A, len: 265 aa. Equivalent to Rv0587,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). yrbE2A, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 311, E(): 1.8e-83, (24.2% identity in 265 aa overlap); NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); etc. Q7U1P9 No NC_002945.3 Mycobrowser_v2 CDS 687171 688058 . + 0 Mb0603 yrbE2B CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE2B Mb0603, yrbE2B, len: 295 aa. Equivalent to Rv0588,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). yrbE2B, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kd protein from Escherichia coli (260 aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 % identity in 267 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protei from Haemophilus influenzae (261 aa),FASTA scores: opt: 234, E(): 6.3e-08, (24.2% identity in 215 aa overlap); NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); etc. Q7U1P8 No NC_002945.3 Mycobrowser_v2 CDS 688064 689278 . + 0 Mb0604 mce2A MCE-FAMILY PROTEIN MCE2A Mb0604, mce2A, len: 404 aa. Equivalent to Rv0589,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 404 aa overlap). mce2A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Also highly similar, but longer 21 aa, to P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1324, E(): 0, (62.6% identity in 436 aa overlap). Contains a possible N-terminal signal or anchor sequence. Note that previously known as mce2. Q7U1P7 No NC_002945.3 Mycobrowser_v2 CDS 689275 690306 . + 0 Mb0605 mce2B mce-family related protein Mb0605, mce2B, len: 343 aa. Equivalent to Rv0590 and Rv0590A, len: 275 aa and 84 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 255 aa overlap and 100.0% identity in 84 aa overlap). mce2B: belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); P45391|YRBD_ECOLI hypothetical 19.6 kd protein from Escherichia coli (183 aa), FASTA scores: opt: 160, E(): 0.00099, (28.3% identity in 166 aa overlap); P45029|YRBD_HAEIN|HI1085 hypothetical protein from Haemophilus influenzae (167 aa), FASTA scores: opt: 135,E():0.035, (25.9% identity in 143 aa overlap); etc. Contains possible N-terminal signal or anchor sequence. Rv0590A: probable continuation of mce2B|Rv0590. Can find no frameshift to account for this. Possible nucleotide G missing at 688793 as there are 5 in Mycobacterium bovis but only 4 in CDC1551. Strong similarity to C-terminus of other Mce proteins e.g. AL583926|AL583926_38 from Mycobacterium leprae strain TN (346 aa), FASTA scores: E(): 1.2e-20, (67.85% identity in 84 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes,most likely to be linked. In Mycobacterium bovis, an in-frame insertion of a single base (*-g) leads to a single product. Q7U1P6 No virulence, detoxification, adaptation Rv0590 NC_002945.3 Mycobrowser_v2 CDS 690303 691748 . + 0 Mb0606 mce2C MCE-FAMILY PROTEIN MCE2C Mb0606, mce2C, len: 481 aa. Equivalent to Rv0591,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 481 aa overlap). mce2C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and may contain N-terminal signal or anchor sequence. Has highly Pro-rich C-terminus. Q7U1P5 No NC_002945.3 Mycobrowser_v2 CDS 705075 705302 . + 0 Mb0626 CONSERVED HYPOTHETICAL PROTEIN Mb0626, -, len: 75 aa. Equivalent to Rv0609A, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Conserved hypothetical protein, highly similar to part of upstream ORF Rv0612|MTCY19H5.09c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (201 aa), FASTA scores: opt: 154, E(): 1.8e-05, (74.3% identity in 35 aa overlap). Q7U1M7 No conserved hypotheticals Rv0609A NC_002945.3 Mycobrowser_v2 CDS 691745 693181 . + 0 Mb0607 mce2Da MCE-FAMILY PROTEIN MCE2DA [FIRST PART] Mb0607, mce2Da, len: 478 aa. Equivalent to 5' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 471 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db. Q7U1P4 No NC_002945.3 Mycobrowser_v2 CDS 693269 693835 . + 0 Mb0609 lprL POSSIBLE MCE-FAMILY LIPOPROTEIN LPRL (MCE-FAMILY LIPOPROTEIN MCE2E) Mb0609, lprL, len: 188 aa. Equivalent to 5' end of Rv0593, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 188 aa overlap). Possible lprL (alternate gene name: mce2E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) introducing a stop codon,leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (188 aa versus 402 aa). Q7U1P3 No NC_002945.3 Mycobrowser_v2 CDS 694482 696032 . + 0 Mb0610 mce2F MCE-FAMILY PROTEIN MCE2F Mb0610, mce2F, len: 516 aa. Equivalent to Rv0594,len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 516 aa overlap). mce2F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Contains possible N-terminal signal or anchor sequence. Q7U1P2 No NC_002945.3 Mycobrowser_v2 CDS 696084 696476 . - 0 Mb0611c vapc4 possible toxin vapc4 Mb0611c, -, len: 130 aa. Equivalent to Rv0595c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112 aa) from Mycobacterium tuberculosis; and STBB_PSESM|Q52562 plasmid stability protein from Pseudomonas syringae (139 aa), FASTA scores: opt: 131, E(): 0.0035, (35.2% identity in 88 aa overlap). Q7U1P1 No virulence, detoxification, adaptation Rv0595c NC_002945.3 Mycobrowser_v2 CDS 696473 696730 . - 0 Mb0612c vapb4 possible antitoxin vapb4 Mb0612c, -, len: 85 aa. Equivalent to Rv0596c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, highly similar in part to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv0626, Rv3181c,Rv3385c, Rv3407, etc. Q7U1P0 No virulence, detoxification, adaptation Rv0596c NC_002945.3 Mycobrowser_v2 CDS 703261 704004 . + 0 Mb0622 possible transposase (fragment) Mb0622, -, len: 247 aa. Equivalent to Rv0606, len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Possible truncated transposase for IS_1536 element, highly similar to N-terminus of other transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (460 aa),FASTA scores: opt: 1368, E(): 0, (83.5% identity in 237 aa overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to N-terminus of MTV002_57|Rv2792 RESOLVASE from M. tuberculosis (193 aa), FASTA score: (87.4% identity in 238 aa overlap). Q7U1N0 No insertion seqs and phages Rv0606 NC_002945.3 Mycobrowser_v2 CDS 730572 731402 . - 0 Mb0650c POSSIBLE EXPORTED PROTEIN Mb0650c, -, len: 276 aa. Equivalent to Rv0633c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 279 aa overlap). Possible exported protein; has hydrophobic stretch at aa 23-41. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (cgggtgcgc-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (276 aa versus 279 aa). Q7U1K7 No cell wall and cell processes Rv0633c NC_002945.3 Mycobrowser_v2 CDS 696913 698148 . - 0 Mb0613c CONSERVED HYPOTHETICAL PROTEIN Mb0613c, -, len: 411 aa. Equivalent to Rv0597c,len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Conserved hypothetical protein, highly similar to Rv3179 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (429 aa). Also similar to AAF76191.1|AF271296_1|AF271296 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa); Rv2008c|YW09_MYCTU|Q10849 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (441 aa), FASTA scores: opt: 270, E(): 3.6e-11, (30.5% identity in 416 aa overlap) (N-terminus longer). Also similar to other hypothetical proteins e.g. NP_085874.1|NC_002679 hypothetical protein from Mesorhizobium loti (435 aa) (N-terminus longer). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1N9 No conserved hypotheticals Rv0597c NC_002945.3 Mycobrowser_v2 CDS 698399 698812 . - 0 Mb0614c vapc27 possible toxin vapc27. contains pin domain. Mb0614c, -, len: 137 aa. Equivalent to Rv0598c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein; similar to Rv2596|Y0B5_MYCTU|Q50625 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (134 aa), FASTA scores: opt: 254, E(): 8.2e-12, (41.5% identity in 130 aa overlap). Q7U1N8 No virulence, detoxification, adaptation Rv0598c NC_002945.3 Mycobrowser_v2 CDS 698809 699045 . - 0 Mb0615c vapb27 possible antitoxin vapb27 Mb0615c, -, len: 78 aa. Equivalent to Rv0599c, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, similar to Rv2595|Y0B6_MYCTU|Q50626 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (81 aa), FASTA scores: opt: 160, E(): 6.2e-07, (35.8% identity in 81 aa overlap). N-terminus shows stong similarity with N-terminus of NP_104908.1|NC_002678 hypothetical protein from Mesorhizobium loti (89 aa). Q7U1N7 No virulence, detoxification, adaptation Rv0599c NC_002945.3 Mycobrowser_v2 CDS 699149 699655 . - 0 Mb0616c two component sensor kinase [second part] Mb0616c, -, len: 168 aa. Equivalent to Rv0600c,len: 168 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 168 aa overlap). Probable two-component sensor kinase (second part) (EC 2.7.3.-), similar to part (C-termini) of many others e.g. Q04943|AFQ2_STRCO sensor protein afsq2 from Streptomyces coelicolor (535 aa), FASTA scores: opt: 347,E(): 1.9e-12, (33.0% identity in 206 aa overlap); etc. Note that sequence was checked and no errors were detected, which would allow this and the upstream ORF to be joined. Q7U1N6 No regulatory proteins Rv0600c NC_002945.3 Mycobrowser_v2 CDS 699769 700239 . - 0 Mb0617c two component sensor kinase [first part] Mb0617c, -, len: 156 aa. Equivalent to Rv0601c,len: 156 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 156 aa overlap). Probable two-component sensor kinase (first part) (EC 2.7.3.-), similar to part (N-termini) of others e.g. Q0375|CUTS_STRLI cuts protein from streptomyces lividans (414 aa), FASTA scores: opt: 230, E(): 3.1e-08,(39.1% identity in 115 aa overlap). Note that the sequence was checked and no errors were detected that would allow this and the downstream ORF to be joined. Q7U1N5 No regulatory proteins Rv0601c NC_002945.3 Mycobrowser_v2 CDS 700283 701044 . - 0 Mb0618c tcrA two component dna binding transcriptional regulatory protein tcra Mb0618c, tcrA, len: 253 aa. Equivalent to Rv0602c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 253 aa overlap). Probable tcrA,two-component DNA-binding response regulator, highly similar to others e.g. NP_107959.1|NC_002678 two-component response regulator from Mesorhizobium loti (239 aa); etc. Also similar to many other Mycobacterium tuberculosis two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c RESPONSE REGULATOR HOMOLOG TRCR (TCRV) (257 aa), FASTA score: (47.4 identity in 232 aa overlap); etc. Q7U1N4 No NC_002945.3 Mycobrowser_v2 CDS 701101 701412 . + 0 Mb0619 POSSIBLE EXPORTED PROTEIN Mb0619, -, len: 103 aa. Equivalent to Rv0603, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(98.1% identity in 103 aa overlap). Possible exported protein with hydrophobic stretch at aa 7-29. Q7U1N3 No cell wall and cell processes Rv0603 NC_002945.3 Mycobrowser_v2 CDS 701484 702434 . + 0 Mb0620 lpqO PROBABLE CONSERVED LIPOPROTEIN LPQO Mb0620, lpqO, len: 316 aa. Equivalent to Rv0604,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 316 aa overlap). Probable lpqO,conserved lipoprotein, highly similar to Rv2999|lppY PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (321 aa), FASTA scores: opt: 1153, E(): 0, (53.2% identity in 312 aa overlap). Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U1N2 No cell wall and cell processes Rv0604 NC_002945.3 Mycobrowser_v2 CDS 702651 703259 . + 0 Mb0621 POSSIBLE RESOLVASE Mb0621, -, len: 202 aa. Equivalent to Rv0605, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Possible resolvase for IS_Y349 element, similar to several Mycobacterial hypothetical proteins and weakly similar to Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa overlap). Contains PS00397 Site-specific recombinases active site and probable helix-turn helix motif from aa 9-30 (Score 1815, +5.37 SD). Q7U1N1 No insertion seqs and phages Rv0605 NC_002945.3 Mycobrowser_v2 CDS 707569 708174 . + 0 Mb0629 CONSERVED HYPOTHETICAL PROTEIN Mb0629, -, len: 201 aa. Equivalent to Rv0612, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Conserved hypothetical protein, highly similar, but in part, to downstream ORF Rv0609A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa); and showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis. Note that first start has been taken although this overlaps slightly with the upstream ORF. Q7U1M4 No conserved hypotheticals Rv0612 NC_002945.3 Mycobrowser_v2 CDS 4152372 4152563 . - 0 Mb3798c PROBABLE REMNANT OF A TRANSPOSASE Mb3798c, -, len: 63 aa. Equivalent to Rv3770B, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 379, E(): 1.6e-21, (93.55% identity in 62 aa overlap). Continues as Rv3770A. Q7TVQ2 No insertion seqs and phages Rv3770B NC_002945.3 Mycobrowser_v2 CDS 708193 710760 . - 0 Mb0630c unknown protein Mb0630c, -, len: 855 aa. Equivalent to Rv0613c,len: 855 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 855 aa overlap). Hypothetical unknown protein. Contains a very short region with strong similarity to several preprotein translocases e.g. P47847|SECA_LISMO preprotein translocase seca subunit (836 aa), FASTA scores: opt: 138, E(): 0.18, (38.6% identity in 70 aa overlap, and 72.7% identity in 22 aa overlap). Q7U1M3 No conserved hypotheticals Rv0613c NC_002945.3 Mycobrowser_v2 CDS 710601 711593 . + 0 Mb0631 CONSERVED HYPOTHETICAL PROTEIN Mb0631, -, len: 330 aa. Equivalent to Rv0614, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Conserved hypothetical protein, similar in part to Mycobacterium tuberculosis hypothetical proteins e.g. YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c CONSERVED HYPOTHETICAL PROTEIN (323 aa), FASTA scores: opt: 200,E(): 0.00016, (28.3% identity in 269 aa overlap); MTCY9F9_15 FASTA score: (40.3% identity in 144 aa overlap), Rv1949c, Rv2542, etc. Several start sites are possible; first start has been chosen. Note that this ORF overlaps with the upstream ORF. Q7U1M2 No conserved hypotheticals Rv0614 NC_002945.3 Mycobrowser_v2 CDS 711590 711832 . + 0 Mb0632 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb0632, -, len: 80 aa. Equivalent to Rv0615, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Probable integral membrane protein. Q7U1M1 No cell wall and cell processes Rv0615 NC_002945.3 Mycobrowser_v2 CDS 711829 712095 . - 0 Mb0633c HYPOTHETICAL PROTEIN Mb0633c, -, len: 88 aa. Equivalent to Rv0616c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein. Q7U1M0 No conserved hypotheticals Rv0616c NC_002945.3 Mycobrowser_v2 CDS 712027 712254 . + 0 Mb0633A vapB29 Possible antitoxin VapB29 Mb0633A, len: 75 aa. Equivalent to Rv0616A len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB29,antitoxin,part of toxin-antitoxin (TA) operon with Rv0617,see Arcus et al. 2005. Similar to many others in M. tuberculosis e.g. Rv2530A (74 aa) 35.9% identity in 78 aa overlap X2BFL8 No virulence, detoxification, adaptation Rv0616A NC_002945.3 Mycobrowser_v2 CDS 712251 712652 . + 0 Mb0634 vapc29 possible toxin vapc29. contains pin domain. Mb0634, -, len: 133 aa. Equivalent to Rv0617, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2494, Rv3320c,Rv0749, Rv0277c, Rv2530c, etc. Q7U1L9 No virulence, detoxification, adaptation Rv0617 NC_002945.3 Mycobrowser_v2 CDS 712781 713965 . + 0 Mb0635 galT probable galactose-1-phosphate uridylyltransferase galtb [second part] Mb0635, galT, len: 394 aa. Equivalent to Rv0618 and Rv0619, len: 231 aa (probable partial CDS) and 181 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 219 aa overlap and 99.4% identity in 174 aa overlap). Rv0618: Probable galT', first part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), highly similar to N-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa),FASTA scores: opt: 296, E(): 1.4e-11, (50.8% identity in 177 aa overlap); etc. Also highly similar to N-terminal half of some UDP glucose--hexose-1-phosphate uridylyltransferases (EC 2.7.7.12). N-terminal 28 aa similar to MTCY20H11.08|Rv0627|MTCY20H11.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), FASTA score: (71.4% identity in 28 aa overlap). BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE >FAMILY 1. Rv0619: Probable 'galT, second part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10),highly similar to C-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa),FASTA scores: opt: 416, E(): 5.2e-22, (43.0% identity in 186 aa overlap), etc. BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FAMILY 1. Cosmid sequence is correct but there may be a frameshift mutation in this region which would allow the two ORFS to be joined. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts,galT' and 'galT. In Mycobacterium bovis, an in-frame insertion of a single base (*-a) leads to a single product. Q7U1L8 No intermediary metabolism and respiration Rv0618 NC_002945.3 Mycobrowser_v2 CDS 757104 757541 . - 0 Mb0680c vapc7 possible toxin vapc7 Mb0680c, -, len: 145 aa. Equivalent to Rv0661c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2863|MTV003.09|MTV003_7 (126 aa), FASTA scores: E(): 0.00087, (30.4% identity in 125 aa overlap),Rv0749|MTV041.23 (163 aa); Rv0277c, Rv2530c, etc. Q7U1I6 No virulence, detoxification, adaptation Rv0661c NC_002945.3 Mycobrowser_v2 CDS 713962 715053 . + 0 Mb0636 galK PROBABLE GALACTOKINASE GALK (GALACTOSE KINASE) Mb0636, galK, len: 363 aa. Equivalent to Rv0620,len: 363 aa, from Mycobacterium tuberculosis strain H37RV,(99.7% identity in 362 aa overlap). Probable galK,galactokinase (EC 2.7.1.6), similar to others e.g. P13227|GAL1_STRLI GALACTOKINASE from Streptomyces lividans (397 aa); P06976|GAL1_ECOLI galactokinase from Escherichia coli (381 aa), FASTA scores: opt: 669, E(): 0, (35.9% identity in 365 aa overlap); etc. Contains PS00106 Galactokinase signature and PS00560 Serine carboxypeptidases, histidine active site. BELONGS TO THE GHMP KINASE FAMILY. GALK SUBFAMILY. X2BFN2,Q7U1L7 No intermediary metabolism and respiration Rv0620 NC_002945.3 Mycobrowser_v2 CDS 715448 716605 . + 0 Mb0637 POSSIBLE MEMBRANE PROTEIN Mb0637, -, len: 385 aa. Equivalent to Rv0621, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 354 aa overlap). Possible membrane protein; contains potential membrane spanning regions. Also contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa). Q7U1L6 No cell wall and cell processes Rv0621 NC_002945.3 Mycobrowser_v2 CDS 716616 717563 . + 0 Mb0638 POSSIBLE MEMBRANE PROTEIN Mb0638, -, len: 315 aa. Equivalent to Rv0622, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 315 aa overlap). Possible membrane protein; contains potential membrane spanning region. Shows weak similarity with Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, etc. Q7U1L5 No cell wall and cell processes Rv0622 NC_002945.3 Mycobrowser_v2 CDS 717656 717910 . + 0 Mb0639 vapb30 possible antitoxin vapb30 Mb0639, -, len: 84 aa. Equivalent to Rv0623, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Conserved hypothetical protein, highly similar to NP_384911.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (84 aa). Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 CONSERVED HYPOTHETICAL PROTEIN (70 aa), FASTA score: (73.5% identity in 68 aa overlap); MTCY4C12_25|Rv0608|MTCY19H5.14c CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA score: (73.5 identity in 68 aa overlap); etc. Q7U1L4 No virulence, detoxification, adaptation Rv0623 NC_002945.3 Mycobrowser_v2 CDS 717910 718305 . + 0 Mb0640 vapc30 possible toxin vapc30. contains pin domain. Mb0640, -, len: 131 aa. Equivalent to Rv0624, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, highly similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1741, Rv0609,Rv2759c,Rv0565c, Rv3854c, Rv3083, etc. X2BFK5,P67241 No virulence, detoxification, adaptation Rv0624 NC_002945.3 Mycobrowser_v2 CDS 718399 719139 . - 0 Mb0641c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0641c, -, len: 246 aa. Equivalent to Rv0625c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Probable conserved transmembrane protein, showing similarity with others e.g. CAB61866.1|AL133252 putative integral membrane protein from Streptomyces coelicolor (249 aa). Also similar to Rv1491c|MTCY277_13 from Mycobacterium tuberculosis. Contains potential membrane spanning regions. X2BFN9,P67116 No cell wall and cell processes Rv0625c NC_002945.3 Mycobrowser_v2 CDS 719271 719531 . + 0 Mb0642 vapb5 possible antitoxin vapb5 Mb0642, -, len: 86 aa. Equivalent to Rv0626, len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv0596c, Rv3385c,Rv3407,Rv3181c, etc. Q7U1L3 No virulence, detoxification, adaptation Rv0626 NC_002945.3 Mycobrowser_v2 CDS 719528 719935 . + 0 Mb0643 vapc5 possible toxin vapc5 Mb0643, -, len: 135 aa. Equivalent to Rv0627, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv0595c and Rv0665. Q7U1L2 No virulence, detoxification, adaptation Rv0627 NC_002945.3 Mycobrowser_v2 CDS 720007 721158 . - 0 Mb0644c CONSERVED HYPOTHETICAL PROTEIN Mb0644c, -, len: 383 aa. Equivalent to Rv0628c,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Conserved hypothetical protein, highly similar to Rv0874c|YZ02_MYCTU|Q10536 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 2082, E(): 0, (81.5% identity in 383 aa overlap). Also some similarity to P72543|SPU62616_1 HYPOTHETICAL PROTEIN from Synechococcus, FASTA scores: E(): 2.8e-28,(36.6 identity in 265 aa overlap). X2BFF5,P64730 No conserved hypotheticals Rv0628c NC_002945.3 Mycobrowser_v2 CDS 757538 757906 . - 0 Mb0681c vapb7 possible antitoxin vapb7 Mb0681c, -, len: 122 aa. Equivalent to Rv0662c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Conserved hypothetical protein, showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2871, Rv1241, Rv2550c, etc. Q7U1I5 No virulence, detoxification, adaptation Rv0662c NC_002945.3 Mycobrowser_v2 CDS 721251 722978 . - 0 Mb0645c recD PROBABLE EXONUCLEASE V (ALPHA CHAIN) RECD (EXODEOXYRIBONUCLEASE V ALPHA CHAIN) (EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0645c, recD, len: 575 aa. Equivalent to Rv0629c,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 575 aa overlap). Probable recD,exonuclease V, alpha chain (exodeoxyribonuclease V, alpha chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_3|AAD46809.1|recD Escherichia coli RecD protein homolog from Mycobacterium smegmatis (554 aa); P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease v 67kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V ALPHA CHAIN) from Escherichia coli strain K12 (608 aa), FASTA scores: opt: 512, E(): 1.9e-24, (36.9% identity in 582 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). CONSIST OF THREE SUBUNITS; RECB|Rv0630c,RECC|Rv0631c AND RECD. Q7U1L1 No NC_002945.3 Mycobrowser_v2 CDS 722975 723679 . - 0 Mb0646c recBb PROBABLE EXONUCLEASE V (BETA CHAIN) RECBB [SECOND PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0646c, recBb, len: 234 aa. Equivalent to 3' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 234 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V, beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb. No NC_002945.3 Mycobrowser_v2 CDS 723565 726258 . - 0 Mb0647c recBa PROBABLE EXONUCLEASE V (BETA CHAIN) RECBA [FIRST PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0647c, recBa, len: 897 aa. Equivalent to 5' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 868 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V,beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb. Q7U1L0 No NC_002945.3 Mycobrowser_v2 CDS 726258 729551 . - 0 Mb0648c recC PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC (EXODEOXYRIBONUCLEASE V GAMMA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) Mb0648c, recC, len: 1097 aa. Equivalent to Rv0631c,len: 1097 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1097 aa overlap). Probable recC,exonuclease V, gamma chain (exodeoxyribonuclease V, gamma chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein homolog from Mycobacterium smegmatis (1085 aa); P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease v 125 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V GAMMA CHAIN) from Escherichia coli strain K12 (1122 aa), FASTA scores: opt: 954, E(): 0, (29.2% identity in 1109 aa overlap); etc. CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC AND RECD|Rv0629c. Q7U1K9 No NC_002945.3 Mycobrowser_v2 CDS 805511 806104 . + 0 Mb0726 rplV 50s ribosomal protein l22 rplv Mb0726, rplV, len: 197 aa. Equivalent to Rv0706,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Probable rplV, 50S ribosomal protein L22, equivalent to O06115|RL22_MYCSM 50S RIBOSOMAL PROTEIN L22 from Mycobacterium smegmatis (153 aa); MBS10OPER_7 50S RIBOSOMAL PROTEIN L22 from Mycobacterium bovis BCG; and MLCB2492_7 50S ribosomal protein L22 from Mycobacterium leprae (175 aa). Also highly similar to others e.g. CAB82075.1|AL161803 50S ribosomal protein L22 from Streptomyces coelicolor (125 aa); P42060|RL22_BACSU 50s ribosomal protein L22 from Bacillus subtilis (113 aa), FASTA scores: opt: 368, E(): 2.4e-13, (52.8% identity in 108 aa overlap); etc. Contains PS00464 Ribosomal protein L22 signature, and contains repetitive sequence at C-terminus. BELONGS TO THE L22P FAMILY OF RIBOSOMAL PROTEINS. X2BFW8,P61180 No information pathways Rv0706 NC_002945.3 Mycobrowser_v2 CDS 729828 730523 . - 0 Mb0649c echA3 PROBABLE ENOYL-COA HYDRATASE ECHA3 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0649c, echA3, len: 231 aa. Equivalent to Rv0632c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Probable echA3,enoyl-CoA hydratase (EC 4.2.1.17), almost identical to the MTU88877_1 enoyl-coA hydratase of Mycobacterium tuberculosis field isolate NTI64719, FASTA score: (92.4% identity in 184 aa overlap). Also similar to others e.g. P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores: opt: 206, E(): 6.3e-07, (31.5% identity in 232 aa overlap); etc. Q7U1K8 No NC_002945.3 Mycobrowser_v2 CDS 731556 732269 . - 0 Mb0651c POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II) Mb0651c, -, len: 237 aa. Equivalent to Rv0634c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Possible glyoxalase II (EC 3.1.2.6), equivalent to NP_302290.1|NC_002677 putative glyoxylase II from Mycobacterium leprae (238 aa); and similar to U00011_3|Y0BK_MYCLE|Q49649 hypothetical 23.9 kd protein from Mycobacterium leprae (218 aa), FASTA scores: opt: 281, E(): 3.9e-12, (31.8% identity in 201 aa overlap). Also similar to other glyoxalases and metallo-beta-lactamase family proteins e.g. NP_386770.1|NC_003047 PUTATIVE HYDROXYACYLGLUTATHIONE HYDROLASE from Sinorhizobium meliloti (256 aa); etc. Also similar to other putative glyoxylases from Mycobacterium tuberculosis e.g. Rv1637c. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS. Q7U1K6 No virulence, detoxification, adaptation Rv0634c NC_002945.3 Mycobrowser_v2 tRNA 732839 732912 . + 0 metT metT tRNA-Met metT, len: 74 nt. Equivalent to metT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Met, anticodon cat. No NC_002945.3 Mycobrowser_v2 CDS 732948 733115 . + 0 Mb0653 rpmG2 50s ribosomal protein l33 rpmg2 Mb0653, rpmG2, len: 55 aa. Equivalent to Rv0634B,len: 55 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 55 aa overlap). Probable rpmG2, 50S ribosomal protein L33. Note that Mycobacterium tuberculosis has a second rpmG gene: P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1 PUTATIVE 50S RIBOSOMAL PROTEIN L33 (55 aa), FASTA scores: opt: 391,E(): 2.9e-25, (100.0% identity in 55 aa overlap). BELONGS TO THE L33P FAMILY OF RIBOSOMAL PROTEINS. X2BFN0,P0A5W3 No NC_002945.3 Mycobrowser_v2 CDS 733166 733642 . + 0 Mb0654 hada (3r)-hydroxyacyl-acp dehydratase subunit hada Mb0654, -, len: 158 aa. Equivalent to Rv0635, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, equivalent to NP_302287.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (159 aa); and highly similar to YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa), FASTA scores: opt: 387, E(): 5.9e-21, (43.4% identity in 145 aa overlap). Also similar CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). And highly similar to two hypothetical proteins from Mycobacterium tuberculosis: Rv0504c|YV31_MYCTU|Q11168 (166 aa), FASTA scores: opt: 405, E(): 3.2e-22, (45.0% identity in 140 aa overlap); and Rv0637|MTY20H10_19 (2 ORFs downstream) (166 aa), FASTA score: (48.7% identity in 150 aa overlap). X2BFG4 No intermediary metabolism and respiration Rv0635 NC_002945.3 Mycobrowser_v2 CDS 733629 734057 . + 0 Mb0655 hadb (3r)-hydroxyacyl-acp dehydratase subunit hadb Mb0655, -, len: 142 aa. Equivalent to Rv0636, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Conserved hypothetical protein, equivalent to NP_302286.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (142 aa). Also highly similar to CAB77411.1|AL160431|SCD82.08 hypothetical protein from Streptomyces coelicolor (142 aa); and similar to others e.g. U28943|CELE04F6_3 from Caenorhabditis elegans (cosmid E04) (298 aa), FASTA scores: opt: 167, E(): 0.00064, (31.6 identity in 117 aa overlap). Q7U1K3 No intermediary metabolism and respiration Rv0636 NC_002945.3 Mycobrowser_v2 CDS 734061 734561 . + 0 Mb0656 hadc (3r)-hydroxyacyl-acp dehydratase subunit hadc Mb0656, -, len: 166 aa. Equivalent to Rv0637, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, equivalent to NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa),FASTA scores: opt: 352, E(): 4e-19, (39.2% identity in 148 aa overlap); and highly similar to others from Mycobacterium leprae e.g. NP_302287.1|NC_002677 conserved hypothetical protein (159 aa). Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa); Rv0635|NP_215149.1|NC_000962|MTY20H10_17 conserved hypothetical protein (two ORFs upstream) from Mycobacterium tuberculosis (158 aa), FASTA score: (49.3% identity in 150 aa overlap); and Rv0504c|NP_215018.1|NC_000962|YV31_MYCTU|Q11168 hypothetical protein from Mycobacterium tuberculosis (166 aa), FASTA scores: opt: 380, E(): 3.8e-21, (43.1% identity in 137 aa overlap). X2BFQ7 No intermediary metabolism and respiration Rv0637 NC_002945.3 Mycobrowser_v2 tRNA 734760 734832 . + 0 trpT trpT tRNA-Trp trpT, len: 73 nt. Equivalent to trpT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Trp, anticodon cca. No NC_002945.3 Mycobrowser_v2 CDS 734973 735458 . + 0 Mb0657 secE1 PROBABLE PREPROTEIN TRANSLOCASE SECE1 Mb0657, secE1, len: 161 aa. Equivalent to Rv0638,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Probable secE1,preprotein translocase (tail-anchored membrane protein),highly similar at C-terminal half to others e.g. P36690|SECE_STRGR PREPROTEIN TRANSLOCASE SECE SUBUNIT from Streptomyces griseus (86 aa), FASTA scores: opt: 220, E(): 4.6e-06, (35.4% identity in 96 aa overlap); P16920|SECE_ECOLI preprotein translocase sece subunit from Escherichia coli strains K12 and O157:H7 (127 aa), FASTA scores: opt: 122, E(): 0.34, (37.0% identity in 54 aa overlap); etc. Contains PS01067 Protein secE/sec61-gamma signature. BELONGS TO THE SECE/SEC61-GAMMA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE, SECF|Rv2586c,SECG|Rv1440 AND SECY|Rv0732. Note that previously known as secE. X2BFN4,P0A5Z1 No NC_002945.3 Mycobrowser_v2 CDS 735490 736206 . + 0 Mb0658 nusG PROBABLE TRANSCRIPTION ANTITERMINATION PROTEIN NUSG Mb0658, nusG, len: 238 aa. Equivalent to Rv0639,len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Probable nusG,transcription antitermination protein, equivalent to NP_302283.1|NC_002677 transcription antitermination protein nusG from Mycobacterium leprae (228 aa). Also highly similar to others e.g. P36260|NUSG_STRGR from Streptomyces griseus (294 aa), FASTA scores: opt: 845,E(): 0, (55.4% identity in 233 aa overlap); etc. Note that shorter at the N-terminus than other nusG. Contains PS01014 Transcription termination factor nusG signature. BELONGS TO THE NUSG FAMILY. X2BFN3,P65590 No information pathways Rv0639 NC_002945.3 Mycobrowser_v2 CDS 736258 736686 . + 0 Mb0659 rplK 50s ribosomal protein l11 rplk Mb0659, rplK, len: 142 aa. Equivalent to Rv0640,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable rplK, 50S ribosomal protein L11, equivalent to NP_302282.1|NC_002677 50S ribosomal protein L11 from Mycobacterium leprae (142 aa). Also highly similar to others e.g. P48954|RL11_STRCO|SCD82.19 50s ribosomal protein L11 from Streptomyces coelicolor (144 aa), FASTA scores: opt: 763,E(): 0, (84.6% identity in 143 aa overlap); etc. Contains PS00359 Ribosomal protein L11 signature. BELONGS TO THE L11P FAMILY OF RIBOSOMAL PROTEINS. X2BFH0,P66057 No information pathways Rv0640 NC_002945.3 Mycobrowser_v2 CDS 737534 738439 . - 0 Mb0661c mmaA4 METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0661c, mmaA4, len: 301 aa. Equivalent to Rv0642c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 301 aa overlap). mmaA4, methoxy mycolic acid synthase 4 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (298 aa); NP_302280.1|NC_002677 methyl mycolic acid synthase 4 from Mycobacterium leprae (298 aa); and highly similar to others from Mycobacteria e.g. downstream ORF P72027|mmaA3|Rv0643c|MTCY20H10.24c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 3 from Mycobacterium tuberculosis (293 aa). X2BFR1,Q7U1K1 No NC_002945.3 Mycobrowser_v2 CDS 738504 739385 . - 0 Mb0662c mmaA3 METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0662c, mmaA3, len: 293 aa. Equivalent to Rv0643c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 293 aa overlap). mmaA3, methoxy mycolic acid synthase 3 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (289 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). X2BFP0,Q7U1K0 No NC_002945.3 Mycobrowser_v2 CDS 739533 740396 . - 0 Mb0663c mmaA2 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 (METHYL MYCOLIC ACID SYNTHASE 2) (MMA2) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0663c, mmaA2, len: 287 aa. Equivalent to Rv0644c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). mmaA2, methoxy mycolic acid synthase 2 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (287 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). Note that alternative start is at position 739247. X2BFN6,Q7U1J9 No NC_002945.3 Mycobrowser_v2 CDS 740563 741423 . - 0 Mb0664c mmaA1 METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) Mb0664c, mmaA1, len: 286 aa. Equivalent to Rv0645c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). mmaA1, methoxy mycolic acid synthase 1 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to NP_302279.1|NC_002677 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). X2BFH5,P0A5Q1 No NC_002945.3 Mycobrowser_v2 CDS 741470 742375 . - 0 Mb0665c lipG PROBABLE LIPASE/ESTERASE LIPG Mb0665c, lipG, len: 301 aa. Equivalent to Rv0646c,len: 301 aa. from Mtycobacterium tuberculosis strain H37Rv, (100.0% identity in 301 aa overlap). Probable lipG,lipase/esterase (EC 3.1.-.-), equivalent to NP_302278.1|NC_002677 probable hydrolase from Mycobacterium leprae (304 aa). Also highly similar to various hydrolases, especially lipases e.g. AA61351.1|X88895 carboxyl esterase from Acinetobacter calcoaceticus (312 aa), FASTA scores: opt: 867, E(): 0,(50.2% identity in 279 aa overlap); etc. Also similar to transferases e.g. P77026 MACROLIDE 2'-PHOSPHOTRANSFERASE II from Escherichia coli (279 aa), FASTA scores: E(): 1.3e-14, (32.5% identity in 286 aa overlap). Similar to M. tuberculosis non-heme bromoperoxidases and epoxide hydrolases. Q7U1J8 No NC_002945.3 Mycobrowser_v2 CDS 742387 743853 . - 0 Mb0666c conserved protein Mb0666c, -, len: 488 aa. Equivalent to Rv0647c,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Conserved hypothetical protein, equivalent to NP_302277.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (448 aa). Also showing similarity to a variety of hypothetical ABC1-LIKE proteins or conserved hypothetical proteins e.g. D90908_28|P73627 ABC1-LIKE PROTEIN from Synechocystis (585 aa), FASTA scores: E(): 1.8e-31, (29.1% identity in 474 aa overlap); Q55884 HYPOTHETICAL6 5.0 KD PROTEIN (567 aa),FASTA scores: opt: 583, E(): 5.7e-30, (28.1% identity in 416 aa overlap); etc. Also similar to Rv3197 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. Q7U1J7 No conserved hypotheticals Rv0647c NC_002945.3 Mycobrowser_v2 CDS 744488 748135 . + 0 Mb0667 ALPHA-MANNOSIDASE Mb0667, -, len: 1215 aa. Equivalent to Rv0648, len: 1215 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 1215 aa overlap). Alpha-mannosidase (EC 3.2.1.-) (see citation below), showing some similarity to hypothetical proteins and various sugar hydrolases e.g. SYCSLRA_6|Q55528 HYPOTHETICAL 1 20.4 KD PROTEIN from Synechocystis (1042 aa), FASTA scores: opt: 260, E(): 3.6e-08, (23.4% identity in 602 aa overlap); etc. Contains PS00659 Glycosyl hydrolases family 5 signature. Q7U1J6 No intermediary metabolism and respiration Rv0648 NC_002945.3 Mycobrowser_v2 CDS 748132 748806 . + 0 Mb0668 fabD2 possible malonyl coa-acyl carrier protein transacylase fabd2 (mct) Mb0668, fabD2, len: 224 aa. Equivalent to Rv0649,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible fabD2,malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39), similar to MTFABD|FABD_MYCTU|Q10501|Rv2243 malonyl CoA-acyl carrier protein transacylase from Mycobacterium tuberculosis (302 aa), FASTA scores: opt: 133, E(): 0.074, (31.3% identity in 147 aa overlap). Q7U1J5 No NC_002945.3 Mycobrowser_v2 CDS 748806 749714 . + 0 Mb0669 POSSIBLE SUGAR KINASE Mb0669, -, len: 302 aa. Equivalent to Rv0650, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Possible sugar kinase, highly similar to others e.g. CAB95296.1|AL359779 putative sugar kinase from Streptomyces coelicolor (317 aa); NP_406512.1|NC_003143 putative sugar kinase from Yersinia pestis (290 aa); NP_229269.1|NC_000853 glucokinase from Thermotoga maritima (317 aa); etc.Contains PS01125 ROK family signature. BELONGS TO THE ROK (NAGC/XYLR) FAMILY. Q7U1J4 No intermediary metabolism and respiration Rv0650 NC_002945.3 Mycobrowser_v2 CDS 750045 750581 . + 0 Mb0670 rplJ 50s ribosomal protein l10 rplj Mb0670, rplJ, len: 178 aa. Equivalent to Rv0651,len: 178 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 178 aa overlap). Probable rplJ, 50S ribosomal protein L10, equivalent to NP_302276.1|NC_002677 50S ribosomal protein L10 from Mycobacterium leprae (177 aa). Also highly similar to others e.g. P36257|RL10_STRGR 50s ribosomal protein L10 from Streptomyces griseus (185 aa), FASTA scores: opt: 633, E(): 0, (59.0 % identity in 173 aa overlap); etc. BELONGS TO THE L10P FAMILY OF RIBOSOMAL PROTEINS. X2BFP4,P66045 No information pathways Rv0651 NC_002945.3 Mycobrowser_v2 CDS 750618 751010 . + 0 Mb0671 rplL 50s ribosomal protein l7/l12 rpll (sa1) Mb0671, rplL, len: 130 aa. Equivalent to Rv0652,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Probable rplL (alternate gene name: L7|L12), 50S ribosomal protein L7/L12, equivalent to NP_302275.1|NC_002677 50S ribosomal protein L7/L12 from Mycobacterium leprae (130 aa); and P37381|RL7_MYCBO 50s ribosomal protein L7/L12 from Mycobacterium bovis (130 aa). Also highly similar to others e.g. P02396|RL7_STRGR 50S RIBOSOMAL PROTEIN L7/L12 from Streptomyces griseus (127 aa); etc. BELONGS TO THE L12P FAMILY OF RIBOSOMAL PROTEINS. X2BFS4,P0A5V3 No information pathways Rv0652 NC_002945.3 Mycobrowser_v2 CDS 751003 751698 . - 0 Mb0672c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb0672c, -, len: 231 aa. Equivalent to Rv0653c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible transcriptional regulator, TetR family, similar in N-terminus to others e.g. CAC03642.1|AL391338 putative TetR-family transcriptional regulator from Streptomyces coelicolor (190 aa); Q51597 CAM REPRESSOR from Pseudomonas putida (186 aa), FASTA scores: opt: 150, E(): 0.00085,(27.8% identity in 97 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis hypothetical transcriptional regulators Rv0681 and Rv1816. Contains probable helix-turn helix motif from aa 27-48 (Score 1156,+3.12 SD). Q7U1J3 No regulatory proteins Rv0653c NC_002945.3 Mycobrowser_v2 CDS 751769 753274 . + 0 Mb0673 PROBABLE DIOXYGENASE Mb0673, -, len: 501 aa. Equivalent to Rv0654, len: 501 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 501 aa overlap). Probable dioxygenase (EC 1.-.-.-), highly similar to others eg AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase (involved in tetraene formation) from Streptomyces antibioticus (456 aa); CAB56138.1| AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); T51734 neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid dioxygenase) from Arabidopsis thaliana (538 aa); Q53353 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE from Pseudomonas paucimobilis (Sphingomonas paucimobilis), FASTA scores: opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa overlap); etc. Also some similarity with Rv0913c|MTCY21C12.07c POSSIBLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa), FASTA score: (29.5% identity in 522 aa overlap). Q7U1J2 No intermediary metabolism and respiration Rv0654 NC_002945.3 Mycobrowser_v2 CDS 753286 754365 . + 0 Mb0674 mkl POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL Mb0674, mkl, len: 359 aa. Equivalent to Rv0655,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Possible mkl,ribonucleotide-transport ATP-binding protein ABC transporter (see first citation below), equivalent to P30769|MKL_MYCLE|ML1892 POSSIBLE RIBONUCLEOTIDE TRANSPORT ATP-BINDING PROTEIN from Mycobacterium leprae (347 aa),FASTA scores: opt: 2021, E(): 0, (92.2% identity in 335 aa overlap). Also highly similar to many e.g. AB92896.1|AL356992 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (343 aa); NP_253146.1|NC_002516 probable ATP-binding component of ABC transporter from Pseudomonas aeruginosa (269 aa); P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding protein from Escherichia coli (269 aa), FASTA scores: opt: 644, E(): 3.4e-33, (38.5% identity in 244 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351 aa), FASTA score: (33.6% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BFI5,P63358 No cell wall and cell processes Rv0655 NC_002945.3 Mycobrowser_v2 CDS 755231 755386 . - 0 Mb0676c vapb6 possible antitoxin vapb6 Mb0676c, -, len: 51 aa. Equivalent to Rv0657c, len: 51 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 51 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa),FASTA scores: opt: 107, E(): 0.0038, (45.8% identity in 48 aa overlap), Rv2871, Rv1560, etc. Also some similarity with AL020958|SC4H8_7 from Streptomyces coelicolor (66 aa), FASTA score: (41.0% identity in 39 aa overlap). Q7U1J0 No virulence, detoxification, adaptation Rv0657c NC_002945.3 Mycobrowser_v2 CDS 755462 756178 . - 0 Mb0677c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0677c, -, len: 238 aa. Equivalent to Rv0658c,len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 238 aa overlap). Probable conserved integral membrane protein, similar to P33774|YPRB_ECOLI hypothetical 24.3 kd protein from Escherichia coli (217 aa), FASTA scores: opt: 174, E(): 5.3e-05, (25.6% identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis. Q7U1I9 No cell wall and cell processes Rv0658c NC_002945.3 Mycobrowser_v2 CDS 756454 756762 . - 0 Mb0678c mazf2 toxin mazf2 Mb0678c, -, len: 102 aa. Equivalent to Rv0659c,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, weakly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1942c, Rv1495, etc. Q7U1I8 No virulence, detoxification, adaptation Rv0659c NC_002945.3 Mycobrowser_v2 CDS 756749 756994 . - 0 Mb0679c maze2 possible antitoxin maze2 Mb0679c, -, len: 81 aa. Equivalent to Rv0660c, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing some similarity to AF016485_130 from Halobacterium sp (100 aa), FASTA scores: (32.4% identity in 74 aa overlap). Q7U1I7 No virulence, detoxification, adaptation Rv0660c NC_002945.3 Mycobrowser_v2 CDS 757906 760269 . + 0 Mb0682 atsD POSSIBLE ARYLSULFATASE ATSD (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE) Mb0682, atsD, len: 787 aa. Equivalent to Rv0663,len: 787 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 787 aa overlap). Possible atsD,arylsulfatase (EC 3.1.6.1), similar to others e.g. P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% identity in 544 aa overlap); etc. Also similar to P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from Mycobacterium tuberculosis (787 aa), FASTA score: (38.9% identity in 769 aa overlap); and other arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa),Rv0711, etc. Contains PS00523 Sulfatases signature 1. BELONGS TO THE SULFATASE FAMILY. Q7U1I4 No intermediary metabolism and respiration Rv0663 NC_002945.3 Mycobrowser_v2 CDS 761576 765094 . + 0 Mb0686 rpoB DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) Mb0686, rpoB, len: 1172 aa. Equivalent to Rv0667,len: 1172 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1172 aa overlap). rpoB,DNA-directed RNA polymerase, beta chain (EC 2.7.7.6) (see first and third citations below), equivalent to P30760|RPOB_MYCLE|ML1891 DNA-directed RNA polymerase beta chain from Mycobacterium leprae (1178 aa). Also highly similar to others e.g. AAF60349.1|AF242549_1|AF242549 DNA-dependent RNA polymerase beta subunit from Amycolatopsis mediterranei (1167 aa); CAB77428.1|AL160431 DNA-directed RNA polymerase beta chain from Streptomyces coelicolor (1161 aa); etc. Start site chosen on basis of RBS but alternative start exists at position 14359. BELONGS TO THE RNA POLYMERASE BETA CHAIN FAMILY. X2BFU0,P0A681 No NC_002945.3 Mycobrowser_v2 CDS 765139 769089 . + 0 Mb0687 rpoC DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). Mb0687, rpoC, len: 1316 aa. Equivalent to Rv0668,len: 1316 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1316 aa overlap). rpoC,DNA-directed RNA polymerase, beta' chain (EC 2.7.7.6) (see first citation below), equivalent to P30761|RPOC_MYCLE|ML1890|S31146 DNA-directed RNA polymerase (EC 2.7.7.6) beta' chain from Mycobacterium leprae (1316 aa), FASTA scores: opt: 8295, E(): 0, (95.6% identity in 1316 aa overlap). Also highly similar to others e.g. CAB77429.1|AL160431 DNA-directed RNA polymerase beta' chain (fragment) from Streptomyces coelicolor (1059 aa); P37871|RPOC_BACSU from Bacillus subtilis (1199 aa), FASTA scores: opt: 2367, E(): 0, (52.9 identity in 1317 aa overlap); etc. BELONGS TO THE RNA POLYMERASE BETA' CHAIN FAMILY. X2BFS1,P0A675 No NC_002945.3 Mycobrowser_v2 CDS 769453 771366 . - 0 Mb0688c POSSIBLE HYDROLASE Mb0688c, -, len: 637 aa. Equivalent to Rv0669c,len: 637 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 637 aa overlap). Possible hydrolase (EC 3.-.-.-), highly similar to various hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 alkaline ceramidase from Pseudomonas aeruginosa (670 aa,) FASTA scores: opt: 1490,E(): 0, (41.2% identity in 651 aa overlap); NP_063946.1|NM_019893 mitochondrial ceramidase from Homo sapiens (761 aa); P_446098.1|NM_053646 N-acylsphingosine amidohydrolase 2 from Rattus norvegicus (761 aa); BAB09641.1|AB016885 neutral ceramidase from Arabidopsis thaliana (705 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1I0 No intermediary metabolism and respiration Rv0669c NC_002945.3 Mycobrowser_v2 CDS 771561 772319 . + 0 Mb0689 end PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Mb0689, end, len: 252 aa. Equivalent to Rv0670,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable end (alternate gene name: nfo), endonuclease IV (apurinase) (EC 3.1.21.2), equivalent to END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV (apurinase) from Mycobacterium leprae (252 aa), FASTA scores: opt: 1463, E(): 0, (85.6% identity in 250 aa overlap). Also similar to others e.g. Q9S2N2|END4_STRCO|NFO|SC6E10.05 PROBABLE ENDONUCLEASE IV from Streptomyces coelicolor (294 aa); etc. Contains PS00729 AP endonucleases family 2 signatures 1 and 2 (PS00729, and PS00730). BELONGS TO THE AP ENDONUCLEASES FAMILY 2. COFACTOR: BINDS 3 ZINC IONS. X2BFK7,P63536 No information pathways Rv0670 NC_002945.3 Mycobrowser_v2 CDS 772351 773193 . + 0 Mb0690 lpqP POSSIBLE CONSERVED LIPOPROTEIN LPQP Mb0690, lpqP, len: 280 aa. Equivalent to Rv0671,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Possible lpqP,conserved lipoprotein, similar to U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302 aa), FASTA scores: opt: 449, E(): 2.4e-22, (37.6% identity in 242 aa overlap). Also highly similar to lpqC|Rv3298c|MTCY71.38c PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (304 aa). Also similar to a large variety of proteins including various esterases and poly(3-hydroxyalkanoate) depolymerases, e.g. NP_249234.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (322 aa); C-terminus of AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase EstA from Piromyces equi (536 aa); part of P52090|PHA1_PSELE POLY(3-HYDROXYALKANOATE) DEPOLYMERASE C PRECURSOR from Pseudomonas lemoignei (414 aa); CAC10310.1|AL442629 putative secreted protein from Streptomyces coelicolor (348 aa); etc. Has a 17 aa signal sequence and contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site. Q7U1H9 No cell wall and cell processes Rv0671 NC_002945.3 Mycobrowser_v2 CDS 773253 774881 . + 0 Mb0691 fadE8 PROBABLE ACYL-COA DEHYDROGENASE FADE8 Mb0691, fadE8, len: 542 aa. Equivalent to Rv0672,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 542 aa overlap). Probable fadE8,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAC33951.1|AL589708 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (557 aa); P33224|AIDB_ECOLI|B4187 aidb protein (ACYL-COA DEHYDROGENASES FAMILY) from Escherichia coli strain K12 (546 aa), FASTA scores: opt: 1369, E(): 0, (44.1% identity in 524 aa overlap); etc. Also similar to several other M. tuberculosis proteins e.g. Rv0154cRv0154c|MTCI5.28c FASTA score: (26.3% identity in 342 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073). BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7U1H8 No NC_002945.3 Mycobrowser_v2 CDS 774892 775830 . + 0 Mb0692 echA4 POSSIBLE ENOYL-COA HYDRATASE ECHA4 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0692, echA4, len: 312 aa. Equivalent to Rv0673,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 312 aa overlap). Possible echA4,enoyl-CoA hydratase (EC 4.2.1.17), showing similarity with others e.g. NP_419216.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (256 aa); Q52995|ECHH_RHIME PROBABLE ENOYL-COA HYDRATASE from Sinorhizobium meliloti (257 aa), FASTA scores: opt: 210, E(): 1.2e-06, (27.9% identity in 280 aa overlap); etc. Also similar to other enoyl-CoA hydratases from Mycobacterium tuberculosis e.g. P95279|MTCY09F9.29|ECHA13|Rv1935c|MTCY09F9.29 ENOYL-COA HYDRATASE (318 aa), FASTA score: (27.1% identity in 280 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1H7 No NC_002945.3 Mycobrowser_v2 CDS 775833 776555 . + 0 Mb0693 CONSERVED HYPOTHETICAL PROTEIN Mb0693, -, len: 240 aa. Equivalent to Rv0674, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Conserved hypothetical protein, highly similar to AC13063.1|AL445503 conserved hypothetical protein from Streptomyces coelicolor (268 aa); and similar to NP_438100.1|NC_003078 putative regulator of phenylacetic acid degradation ArsR family protein from Sinorhizobium meliloti (306 aa) and other proteins e.g. AB011837|AB011837_13 hypothetical protein from Bacillus halodurans (298 aa), FASTA scores: opt: 148, E(): 0.0081, (25.1% identity in 235 aa overlap); etc. Q7U1H6 No conserved hypotheticals Rv0674 NC_002945.3 Mycobrowser_v2 CDS 776552 777343 . + 0 Mb0694 echA5 PROBABLE ENOYL-COA HYDRATASE ECHA5 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0694, echA5, len: 263 aa. Equivalent to Rv0675,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 263 aa overlap). Probable echA5,enoyl-CoA hydratase (EC 4.2.1.17), similar to several e.g. NP_252116.1|NC_002516 probable enoyl CoA-hydratase/isomerase from Pseudomonas aeruginosa (256 aa); Q20376 PROTEIN SIMILAR TO ENOYL-COA HYDRATASE from Caenorhabditis elegans (258 aa), FASTA scores: opt: 697,E(): 0, (47.3% identity in 245 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Z92669|MTCY8D5_17 (262 aa), FASTA scores: opt: 493, E(): 3.6e-25, (39.1% identity in 243 aa overlap); etc. Q7U1H5 No NC_002945.3 Mycobrowser_v2 CDS 883922 884608 . + 0 Mb0810 unknown protein Mb0810, -, len: 228 aa. Equivalent to hypothetical protein MT0811, len: 242 aa, from Mycobacterium tuberculosis strain CDC1551 (94% identity with 228 aa overlap). Hypothetical unknown protein, equivalent to AAK45053.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 77 aa. Mb0810 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BG72 No NC_002945.3 Mycobrowser_v2 CDS 783703 784173 . + 0 Mb0702 rpsG 30s ribosomal protein s7 rpsg Mb0702, rpsG, len: 156 aa. Equivalent to Rv0683,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Probable rpsG, 30S ribosomal protein S7 (see citation below), equivalent to others from Mycobacteria e.g. P41193|RS7_MYCSM 30S RIBOSOMAL PROTEIN S7 from Mycobacterium smegmatis (156 aa), FASTA scores: opt: 986, E(): 0, (96.2% identity in 156 aa overlap); Q53539|RS7_MYCBO 30S RIBOSOMAL PROTEIN S7 from Mycobacterium bovis (156 aa); etc. Also highly similar to others e.g. Q9L0K4|RS7_STRCO 30S RIBOSOMAL PROTEIN S7 from Streptomyces coelicolor (156 aa); etc. Contains PS00052 Ribosomal protein S7 signature. BELONGS TO THE S7P FAMILY OF RIBOSOMAL PROTEINS. X2BFT8,Q53539 No information pathways Rv0683 NC_002945.3 Mycobrowser_v2 CDS 777355 780249 . - 0 Mb0695c mmpL5 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL5 Mb0695c, mmpL5, len: 964 aa. Equivalent to Rv0676c,len: 964 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 964 aa overlap). Probable mmpL5,conserved transmembrane transport protein (see first citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. MTV037_14, MTCY98_8,MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19,etc. Also similar to other Mycobacterial mmpl proteins e.g. P54881|MML4_MYCLE PUTATIVE MEMBRANE PROTEIN MMPL4 from Mycobacterium leprae (959 aa), FASTA scores: opt: 3991, E(): 0, (62.8% identity in 933 aa overlap); etc. BELONGS TO THE MMPL FAMILY. TBparse score is 0.884. Q7U1H4 No NC_002945.3 Mycobrowser_v2 CDS 780246 780674 . - 0 Mb0696c mmpS5 POSSIBLE CONSERVED MEMBRANE PROTEIN MMPS5 Mb0696c, mmpS5, len: 142 aa. Equivalent to Rv0677c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Possible mmpS5,conserved membrane protein (see first citation below),highly similar to other Mycobacterial proteins e.g. P54880|MMS4_MYCLE PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 443,E(): 1.4e-23, (47.1% identity in 155 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis. BELONGS TO THE MMPS FAMILY. TBparse score is 0.901. X2BFV2,P65381 No NC_002945.3 Mycobrowser_v2 CDS 780759 781256 . + 0 Mb0697 conserved protein Mb0697, -, len: 165 aa. Equivalent to Rv0678, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical protein, showing weak similarity with AL049754|SCH10_10 hypothetical protein from Streptomyces coelicolor (152 aa), FASTA scores: opt: 149, E(): 0.0018,(22.9% identity in 140 aa overlap). TBparse score is 0.910. Q7U1H3 No conserved hypotheticals Rv0678 NC_002945.3 Mycobrowser_v2 CDS 781312 781809 . - 0 Mb0698c conserved threonine rich protein Mb0698c, -, len: 165 aa. Equivalent to Rv0679c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical Thr-rich protein, similar in part to neighboring ORF Rv0680c (124 aa), FASTA score: (35.1% identity in 131 aa overlap); and Rv0314c (220 aa). Contains probable N-terminal signal sequence. TBparse score is 0.894. Q7U1H2 No conserved hypotheticals Rv0679c NC_002945.3 Mycobrowser_v2 CDS 781811 782185 . - 0 Mb0699c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0699c, -, len: 124 aa. Equivalent to Rv0680c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Possible conserved transmembrane protein, showing similarity with C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved hypothetical protein from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 175, E(): 2.2e-05, (31.4% identity in 102 aa overlap). Also some similarity to upstream ORF Rv0679c|MTV040.07c CONSERVED HYPOTHETICAL THREONINE RICH PROTEIN (124 aa), FASTA score: (35.1% identity in 131 aa overlap). Contains probable N-terminal signal sequence. Q7U1H1 No cell wall and cell processes Rv0680c NC_002945.3 Mycobrowser_v2 CDS 782490 783080 . + 0 Mb0700 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) Mb0700, -, len: 196 aa. Equivalent to Rv0681, len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable transcription regulator, TetR family, similar to others and especially many tetracycline repressors e.g. T34657 probable transcription regulator from Streptomyces coelicolor (189 aa); AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator from Bacillus subtilis (191 aa), FASTA scores: opt: 213,E(): 1.6e-07, (28.8% identity in 153 aa overlap); P09164|TER4_ECOLI TETRACYCLINE REPRESSOR PROTEIN from Escherichia coli (217 aa), FASTA scores: opt: 145, E(): 0.0068, (39.0% identity in 59 aa overlap); etc. Contains helix-turn-helix motif at aa 28-49 (Score 1020, +2.66 SD). Q7U1H0 No regulatory proteins Rv0681 NC_002945.3 Mycobrowser_v2 CDS 783329 783703 . + 0 Mb0701 rpsL 30s ribosomal protein s12 rpsl Mb0701, rpsL, len: 124 aa. Equivalent to Rv0682,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Probable rpsL, 30S ribosomal protein S12 (see citations below), equivalent to others from Mycobacteria e.g. P41195|RS12_MYCSM 30S RIBOSOMAL PROTEIN S12 from Mycobacterium smegmatis (124 aa); P51999|RS12_MYCAV 30S RIBOSOMAL PROTEIN S12 from Mycobacterium avium (124 aa); etc. Also highly similar to others from other organisms e.g. P97222|RS12_STRCO 30S RIBOSOMAL PROTEIN S12 from Streptomyces roseosporus,lividans and coelicolor (123 aa); etc. Contains PS00055 Ribosomal protein S12 signature. BELONGS TO THE S12P FAMILY OF RIBOSOMAL PROTEINS. X2BFV8,Q53538 No information pathways Rv0682 NC_002945.3 Mycobrowser_v2 CDS 824688 825416 . + 0 Mb0751 gcn5-related n-acetyltransferase Mb0751, -, len: 242 aa. Equivalent to Rv0730, len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical protein, only equivalent to Z98756|MLCB2492_26 HYPOTHETICAL PROTEIN from Mycobacterium leprae (227 aa), FASTA scores: opt: 1180, E(): 0, (83.5% identity in 218 aa overlap). O53794 No intermediary metabolism and respiration Rv0730 NC_002945.3 Mycobrowser_v2 CDS 784254 786359 . + 0 Mb0703 fusA1 PROBABLE ELONGATION FACTOR G FUSA1 (EF-G) Mb0703, fusA1, len: 701 aa. Equivalent to Rv0684,len: 701 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 701 aa overlap). Probable fusA1,elongation factor G, equivalent to P30767|EFG_MYCLE|S31150 translation elongation factor EF-G from Mycobacterium leprae (701 aa), FASTA scores: opt: 2521, E(): 0, (88.2% identity in 432 aa overlap). Also highly similar to others e.g. CAB81852.1|AL161691 elongation factor G from Streptomyces coelicolor (708 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. Note that previously known as fusA. X2BFQ9,P0A557 No NC_002945.3 Mycobrowser_v2 CDS 786590 787780 . + 0 Mb0704 tuf probable iron-regulated elongation factor tu tuf (ef-tu) Mb0704, tuf, len: 396 aa. Equivalent to Rv0685,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Probable tuf,elongation factor EF-Tu, equivalent to JC2262 translation elongation factor Tu from Mycobacterium leprae (396 aa). Also highly similar to others e.g. P42439|EFTU_CORGL ELONGATION FACTOR TU (EF-TU) from Corynebacterium glutamicum (396 aa); etc. Contains PS00017 ATP/GTP-binding site motif A, and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-TU/EF-1A SUBFAMILY. X2BFM6,P0A559 No information pathways Rv0685 NC_002945.3 Mycobrowser_v2 CDS 788868 789695 . + 0 Mb0706 probable short-chain type dehydrogenase/reductase Mb0706, -, len: 275 aa. Equivalent to Rv0687, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases (generally SDR family) e.g. U17129|RSU17129_7 short-chain dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 1112, E(): 0, (61.2% identity in 268 aa overlap); MMU34072_2 steroid dehydrogenase from Musmus culus (260 aa), FASTA scores: opt: 390, E(): 2.2e-17, (34.1% identity in 267 aa overlap); etc. Also similar to MTV002_16|O33292|Rv2750 DEHYDROGENASE from Mycobacterium tuberculosis (272 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Q7U1G8 No intermediary metabolism and respiration Rv0687 NC_002945.3 Mycobrowser_v2 CDS 789709 790929 . + 0 Mb0707 PUTATIVE FERREDOXIN REDUCTASE Mb0707, -, len: 406 aa. Equivalent to Rv0688, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Putative ferredoxin reductase (EC 1.-.-.-), highly similar to others e.g. BAB55881.1|AB054975 ferredoxin reductase from Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); PPU24215_8|Q51973 P-CUMATE DIOXYGENASE FERREDOXIN REDUCTASE SUBUNIT from Pseudomonas putida (402 aa), FASTA scores: opt: 738, E(): 0, (38.8% identity in 330 aa overlap); etc. Also similar to Rv0253 and Rv1869c from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY. Q7U1G7 No intermediary metabolism and respiration Rv0688 NC_002945.3 Mycobrowser_v2 CDS 790926 791180 . - 0 Mb0708c HYPOTHETICAL PROTEIN Mb0708c, -, len: 84 aa. Equivalent to Rv0689c, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Hypothetical unknown protein. Q7U1G6 No conserved hypotheticals Rv0689c NC_002945.3 Mycobrowser_v2 CDS 791793 792842 . - 0 Mb0709c CONSERVED HYPOTHETICAL PROTEIN Mb0709c, -, len: 349 aa. Equivalent to Rv0690c,len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Conserved hypothetical protein, showing similarity with NP_386956.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063 AGR_L_1570p from Agrobacterium tumefaciens (346 aa); NP_421938.1|NC_002696 conserved hypothetical protein from Caulobacter crescentus (370 aa). Q7U1G5 No conserved hypotheticals Rv0690c NC_002945.3 Mycobrowser_v2 CDS 792839 793435 . - 0 Mb0710c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0710c, -, len: 198 aa. Equivalent to Rv0691c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 198 aa overlap). Rv0691c,(MTCY210.08c), len: 198 aa. Probable transcriptional regulator, highly similar to AAC77476.1|U17129 unknown protein from Rhodococcus erythropolis (185 aa); and showing similarity with putative regulatory proteins eg STMTCREP_1|TCMR_STRGA|P39885 tetracenomycin c transcriptional repressor from Streptomyces glaucescens (226 aa), FASTA scores: opt: 178, E(): 8.5e-06, (27.9% identity in 201 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and probable helix-turn helix motifs from aa 34-55 (Score 1100, +2.93 SD) and 151-172 (Score 1124, +3.02 SD). Q7U1G4 No regulatory proteins Rv0691c NC_002945.3 Mycobrowser_v2 CDS 793427 793615 . + 0 Mb0710A Mycofactocin precursor protein Mb0710A, len: 62 aa. Equivalent to Rv0691A len: 62 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Mycofactocin precursor protein. X2BFW7 No intermediary metabolism and respiration Rv0691A NC_002945.3 Mycobrowser_v2 CDS 793600 793929 . + 0 Mb0711 CONSERVED HYPOTHETICAL PROTEIN Mb0711, -, len: 109 aa. Equivalent to Rv0692, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Conserved hypothetical protein, highly similar to U17129|RSU17129_3|AAC77477.1 unknown protein from Rhodococcus erythropolis (95 aa), FASTA scores: opt: 393,E(): 8.8e-22, (68.2% identity in 88 aa overlap). Q7U1G3 No conserved hypotheticals Rv0692 NC_002945.3 Mycobrowser_v2 CDS 793926 795101 . + 0 Mb0712 pqqE PROBABLE COENZYME PQQ SYNTHESIS PROTEIN E PQQE (COENZYME PQQ SYNTHESIS PROTEIN III) Mb0712, pqqE, len: 391 aa. Equivalent to Rv0693,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 391 aa overlap). Probable pqqE (alternate gene name: pqqIII), coenzyme PQQ synthesis protein E, similar to others AE001109_9|O30258|PQQE COENZYME PQQ SYNTHESIS PROTEIN from Archaeoglobus fulgidus (375 aa), FASTA scores: E(): 1.6e-16, (28.1% identity in 377 aa overlap); PQQE_ACICA|P07782 coenzyme pqq synthesis protein e from Acinetobacter calcoaceticus (384 aa), FASTA scores: opt: 302, E(): 1.8e-12, (23.9% identity in 377 aa overlap); etc. Also similar to C-terminus of heme biosynthesis proteins e.g. O28270|AF2009 HEME BIOSYNTHESIS PROTEIN (NIRJ-2) from Archaeoglobus fulgidus (468 aa). Note that also highly similar to U17129|RSU17129_4|AAC77478.1 unknown protein from Rhodococcus erythropolis (405 aa), FASTA scores: opt: 1997, E(): 0, (73.3% identity in 390 aa overlap). COULD BELONG TO THE MOAA / NIFB / PQQE FAMILY. Q7U1G2 No intermediary metabolism and respiration Rv0693 NC_002945.3 Mycobrowser_v2 CDS 795104 796294 . + 0 Mb0713 lldD1 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD1 Mb0713, lldD1, len: 396 aa. Equivalent to Rv0694,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Possible lldD1,L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar to NP_302368.1|NC_002677 L-lactate dehydrogenase from Mycobacterium leprae (414 aa). Also similar to others e.g. NP_384560.1|NC_003047 PUTATIVE L-LACTATE DEHYDROGENASE (CYTOCHROME) PROTEIN from Sinorhizobium meliloti (403 aa); NP_251072.1|NC_002516 L-lactate dehydrogenase from Pseudomonas aeruginosa (383 aa); P33232|LLDD_ECOLI L-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa), FASTA scores: opt: 697, E(): 0, (34.5 identity in 380 aa overlap); etc; and also similar to other oxidoreductases. Note that also highly similar to RSU17129_5|AAC77479.1|U17129 unknown protein from Rhodococcus erythropolis (392 aa), FASTA scores: opt: 2006, E(): 0, (74.1% identity in 386 aa overlap). Also similar to lldD2|Rv1872c|MTCY180.46|MTCY359.01 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis (414 aa). BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY. Q7U1G1 No NC_002945.3 Mycobrowser_v2 CDS 1600239 1601066 . - 0 Mb1463c CONSERVED HYPOTHETICAL PROTEIN Mb1463c, -, len: 275 aa. Equivalent to Rv1428c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins from M. tuberculosis e.g. Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: opt: 355, E(): 5e-16, (32.6% identity in 273 aa overlap); and Rv1920. Q7U036 No conserved hypotheticals Rv1428c NC_002945.3 Mycobrowser_v2 CDS 796484 797239 . + 0 Mb0714 CONSERVED HYPOTHETICAL PROTEIN Mb0714, -, len: 251 aa. Equivalent to Rv0695, len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Conserved hypothetical protein, similar to many creatinine amidohydrolases or hypothetical proteins e.g. NP_443048.1|NC_000911 creatinine amidohydrolase from Synechococcus sp. PCC 6803 (273 aa); NP_466169.1|NC_003210 protein similar to creatinine amidohydrolase from Listeria monocytogenes (249 aa); T35153|SC5A7.04c hypothetical protein from Streptomyces coelicolor (273 aa); etc. Note that highly similar to RSU17129_10|AAC77474.1|U17129 unknown protein from Rhodococcus erythropolis (230 aa),FASTA scores: opt: 693, E(): 0, (55.7% identity in 237 aa overlap). Q7U1G0 No conserved hypotheticals Rv0695 NC_002945.3 Mycobrowser_v2 CDS 797288 798700 . + 0 Mb0715 PROBABLE MEMBRANE SUGAR TRANSFERASE Mb0715, -, len: 470 aa. Equivalent to Rv0696, len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 470 aa overlap). Probable membrane sugar transferase (EC 2.-.-.-), similar (except in N-terminus) to NP_069157.1|NC_000917 glycosyl transferase from Archaeoglobus fulgidus (324 aa); NP_279985.1|NC_002607 rhamnosyl transferase from Halobacterium sp. NRC-1 (299 aa); NP_059113.1|NM_017417 polypeptide N-acetylgalactosaminyltransferase 8 from (637 aa). Note that also highly similar to P46370|YTH1_RHOER HYPOTHETICAL 55.3 KDA PROTEIN from Rhodococcus erythropolis (513 aa), FASTA scores: opt: 1514, E(): 0,(51.8% identity in 469 aa overlap). Q7U1F9 No intermediary metabolism and respiration Rv0696 NC_002945.3 Mycobrowser_v2 CDS 798702 800141 . + 0 Mb0716 PROBABLE DEHYDROGENASE Mb0716, -, len: 479 aa. Equivalent to Rv0697, len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Probable dehydrogenase (EC 1.-.-.-), highly similar to P30772|YTUR_MYCLE HYPOTHETICAL 24 KD PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 557,E(): 1.7e-28, (46.2% identity in 223 aa overlap). Also highly similar to P46371|YTH2_RHOER HYPOTHETICAL 53.0 KDA GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa); and similar to many dehydrogenases e.g. NP_250814.1|NC_002516 probable dehydrogenase from Pseudomonas aeruginosa (545 aa); BAA13145.1|D86622 FAD dependent L-sorbose dehydrogenase from Gluconobacter oxydans (531 aa); etc. Also similar to Rv1279 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. Q7U1F8 No intermediary metabolism and respiration Rv0697 NC_002945.3 Mycobrowser_v2 CDS 808157 808603 . + 0 Mb0731 atsAa POSSIBLE ARYLSULFATASE ATSAa [FIRST PART] (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE) Mb0731, atsAa, len: 148 aa. Equivalent to 5' end of Rv0711, len: 787 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 148 aa overlap). Possible atsA, arylsulfatase (EC 3.1.6.1), similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439,E(): 2.9e-21, (30.8% identity in 552 aa overlap); etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases signature 1, and PS00149 Sulfatases signature 2. BELONGS TO THE SULFATASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t),introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb. Q7U1F3 No NC_002945.3 Mycobrowser_v2 CDS 819361 820266 . - 0 Mb0746c CONSERVED HYPOTHETICAL PROTEIN Mb0746c, -, len: 301 aa. Equivalent to Rv0725c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c, Rv0731c,Rv3399, etc, e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical 36.1 kd protein cy31.21c (325 aa), FASTA scores: opt: 600,E(): 3.9e-32, (43.8% identity in 219 aa overlap). X2BFZ0,Q7U1E7 No conserved hypotheticals Rv0725c NC_002945.3 Mycobrowser_v2 CDS 800602 800931 . + 0 Mb0717 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb0717, -, len: 109 aa. Equivalent to 5' end of Rv0698, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 106 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 2.1e-07, (54.8% identity in 73 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718. Q7U1F7 No NC_002945.3 Mycobrowser_v2 CDS 800979 801212 . + 0 Mb0718 CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb0718, -, len: 77 aa. Equivalent to 3' end of Rv0698, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 77 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 2.1e-07, (54.8% identity in 73 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718. Q7U1F6 No NC_002945.3 Mycobrowser_v2 CDS 801397 801618 . + 0 Mb0719 HYPOTHETICAL PROTEIN Mb0719, -, len: 73 aa. Equivalent to Rv0699, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Hypothetical unknown protein. Q7U1F5 No conserved hypotheticals Rv0699 NC_002945.3 Mycobrowser_v2 CDS 802255 802560 . + 0 Mb0720 rpsJ 30S RIBOSOMAL PROTEIN S10 RPSJ (TRANSCRIPTION ANTITERMINATION FACTOR NUSE) Mb0720, rpsJ, len: 101 aa. Equivalent to Rv0700,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). rpsJ (alternate gene name: nusE), 30S ribosomal protein S10 (see first citation below), equivalent to RS10_MYCLE P307653 30S ribosomal protein S10 from Mycobacterium leprae (101 aa), FASTA scores: opt: 645, E(): 0, (97.0% identity in 101 aa overlap). Also highly similar to others e.g. CAB82069.1|AL161803 30S ribosomal protein S10 from Streptomyces coelicolor (102 aa); etc. Contains PS00361 Ribosomal protein S10 signature. BELONGS TO THE S10P FAMILY OF RIBOSOMAL PROTEINS. X2BFX5,P0A5X1 No information pathways Rv0700 NC_002945.3 Mycobrowser_v2 CDS 802577 803230 . + 0 Mb0721 rplC 50s ribosomal protein l3 rplc Mb0721, rplC, len: 217 aa. Equivalent to Rv0701,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Probable rplC, 50S ribosomal protein L3, equivalent to O06044|RL3_MYCBO 50S RIBOSOMAL PROTEIN L3 from Mycobacterium bovis BCG (217 aa); and P30762|RL3_MYCLE 50S RIBOSOMAL PROTEIN L3 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. CAB82070.1|AL161803 50S ribosomal protein L3 from Streptomyces coelicolor (214 aa); P52860|RL3_THETH ribosomal protein l3 from Thermus aquaticus (206 aa),FASTA scores: opt: 717, E(): 0, (55.2% identity in 210 aa overlap); etc. Contains PS00474 Ribosomal protein L3 signature. BELONGS TO THE L3P FAMILY OF RIBOSOMAL PROTEINS. X2BFW2,P60441 No information pathways Rv0701 NC_002945.3 Mycobrowser_v2 CDS 2130721 2130939 . + 0 Mb1926 CONSERVED HYPOTHETICAL PROTEIN Mb1926, -, len: 72 aa. Equivalent to Rv1893, len: 72 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Conserved hypothetical protein. Equivalent to MLCB561.11|AL049571 hypothetical protein from Mycobacterium leprae (74 aa), FASTA scores: opt: 317, E(): 4.6e-15, (69.4% identity in 72 aa overlap). Q7TZC4 No conserved hypotheticals Rv1893 NC_002945.3 Mycobrowser_v2 CDS 803230 803901 . + 0 Mb0722 rplD 50s ribosomal protein l4 rpld Mb0722, rplD, len: 223 aa. Equivalent to Rv0702,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Probable rplD, 50S ribosomal protein L4, equivalent to O06045|RL4_MYCBO 50S RIBOSOMAL PROTEIN L4 from Mycobacterium bovis BCG (223 aa); O06114|RL4_MYCSM 50S RIBOSOMAL PROTEIN L4 from Mycobacterium smegmatis (215 aa); and MLCB2492_3 50S ribosomal protein L4 from Mycobacterium leprae (230 aa). Also highly similar to others e.g. CAB82071.1|AL161803 50S ribosomal protein L4 from Streptomyces coelicolor (219 aa); P28601|RL4_BACST 50s ribosomal protein L4 from Bacillus stearothermophilus (207 aa), FASTA scores: opt: 522, E(): 3.5e-26, (42.4% identity in 198 aa overlap); etc. BELONGS TO THE L4P FAMILY OF RIBOSOMAL PROTEINS. X2BFS0,P60728 No information pathways Rv0702 NC_002945.3 Mycobrowser_v2 CDS 803901 804203 . + 0 Mb0723 rplW 50s ribosomal protein l23 rplw Mb0723, rplW, len: 100 aa. Equivalent to Rv0703,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Probable rplW, 50S ribosomal protein L23, equivalent to O06046|RL23_MYCBO 50S RIBOSOMAL PROTEIN L23 from Mycobacterium bovis BCG (100 aa); and MLCB2492_4 50S RIBOSOMAL PROTEIN L23 from Mycobacterium leprae (100 aa). Also highly similar to others e.g. CAB82072.1|AL161803 50S ribosomal protein L23 from Streptomyces coelicolor (139 aa) (N-terminus longer); P04454|RL23_BACST 50s ribosomal protein L23 from Bacillus stearothermophilus (95 aa), FASTA scores: opt: 275, E(): 1.4e-13, (50.5% identity in 95 aa overlap); etc. Contains PS00050 Ribosomal protein L23 signature. BELONGS TO THE L23P FAMILY OF RIBOSOMAL PROTEINS. X2BFQ3,O06046 No information pathways Rv0703 NC_002945.3 Mycobrowser_v2 CDS 804350 805192 . + 0 Mb0724 rplB 50s ribosomal protein l2 rplb Mb0724, rplB, len: 280 aa. Equivalent to Rv0704,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable rplB, 50S ribosomal protein L2, equivalent to O06047|RL2_MYCBO 50S RIBOSOMAL PROTEIN L2 from Mycobacterium bovis BCG (280 aa); and MLCB2492_5M 50S RIBOSOMAL PROTEIN L2 from Mycobacterium leprae (280 aa). Also highly similar to others e.g. CAB82073.1|AL161803 50S ribosomal protein L2 from Streptomyces coelicolor (278 aa); P42919|RL2_BACSU 50s ribosomal protein l2 (bl2) from Bacillus subtilis (276 aa), FASTA scores: opt: 1179, E(): 0, (61.1% identity in 275 aa overlap); etc. Contains PS00467 Ribosomal protein L2 signature. BELONGS TO THE L2P FAMILY OF RIBOSOMAL PROTEINS. X2BFW0,O06047 No information pathways Rv0704 NC_002945.3 Mycobrowser_v2 CDS 805233 805514 . + 0 Mb0725 rpsS 30s ribosomal protein s19 rpss Mb0725, rpsS, len: 93 aa. Equivalent to Rv0705,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable rpsS, 30S ribosomal protein S19, equivalent to S36895 ribosomal protein S19 from Mycobacterium bovis (93 aa), FASTA scores: opt: 623, E(): 0, (98.9% identity in 93 aa overlap); and NP_302261.1|NC_002677 30S ribosomal protein S19 from Mycobacterium leprae (93 aa). Also highly similar to others e.g. CAB82074.1|AL161803 30S ribosomal protein S19 from Streptomyces coelicolor (93 aa); etc. Contains PS00323 Ribosomal protein S19 signature. BELONGS TO THE S19P FAMILY OF RIBOSOMAL PROTEINS. X2BFY0,P0A5X5 No information pathways Rv0705 NC_002945.3 Mycobrowser_v2 CDS 1619634 1620044 . - 0 Mb1479c unknown protein Mb1479c, -, len: 136 aa. Equivalent to Rv1444c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Hypothetical unknown protein. Q7U024 No conserved hypotheticals Rv1444c NC_002945.3 Mycobrowser_v2 CDS 806104 806928 . + 0 Mb0727 rpsC 30s ribosomal protein s3 rpsc Mb0727, rpsC, len: 274 aa. Equivalent to Rv0707,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Probable rpsC, 30S ribosomal protein S3, equivalent to O06048|RS3_MYCBO|MBS10OPER_8 30S RIBOSOMAL PROTEIN S3 from Mycobacterium bovis BCG (274 aa); and MLCB2492_8 30S RIBOSOMAL PROTEIN S3 from Mycobacterium leprae (281 aa). Also highly similar to others e.g. CAB82076.1|AL161803 30S ribosomal protein S3 from Streptomyces coelicolor (277 aa); P21465|RS3_BACSU 30s ribosomal protein s3 (bs3) (bs2) from Bacillus subtilis (217 aa), FASTA scores: opt: 794,E(): 0, (52.8% identity in 212 aa overlap); etc. BELONGS TO THE S3P FAMILY OF RIBOSOMAL PROTEINS. X2BFS3,P0A5X7 No information pathways Rv0707 NC_002945.3 Mycobrowser_v2 CDS 806932 807348 . + 0 Mb0728 rplP 50s ribosomal protein l16 rplp Mb0728, rplP, len: 138 aa. Equivalent to Rv0708,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Probable rplP, 50S ribosomal protein L16, equivalent to O06049|RL16_MYCBO|MBS10OPER_9 50S RIBOSOMAL PROTEIN L16 from Mycobacterium bovis BCG (138 aa); and MLCB2492_9 50S RIBOSOMAL PROTEIN L16 from Mycobacterium leprae (138 aa). Also highly similar to others e.g. CAB82077.1|AL161803 50S ribosomal protein L16 from Streptomyces coelicolor (139 aa); P14577|RL16_BACSU 50s ribosomal protein l16 from Bacillus subtilis (144 aa), FASTA scores: opt: 600, E(): 0, (63.2% identity in 136 aa overlap); etc. Contains PS00701 Ribosomal protein L16 signature 2. BELONGS TO THE L16P FAMILY OF RIBOSOMAL PROTEINS. X2BFR0,O06049 No information pathways Rv0708 NC_002945.3 Mycobrowser_v2 CDS 807348 807581 . + 0 Mb0729 rpmC 50s ribosomal protein l29 rpmc Mb0729, rpmC, len: 77 aa. Equivalent to Rv0709,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Probable rpmC, 50S ribosomal protein L29, equivalent to O06050|RL29_MYCBO|MBS10OPER_10 50S RIBOSOMAL PROTEIN L29 from Mycobacterium bovis BCG (75 aa); and O32989|RL29_MYCLE|MLCB2492_10 50S RIBOSOMAL PROTEIN L29 from Mycobacterium leprae (80 aa). Also highly similar to others e.g. Q9L0D2|RL29_STRCO 50S RIBOSOMAL PROTEIN L29 from Streptomyces coelicolor (74 aa); P12873|RL29_BACSU 50s ribosomal protein l29 from Bacillus subtilis (66 aa),FASTA scores: opt: 225, E(): 8.3e-11, (58.6% identity in 58 aa overlap); etc. BELONGS TO THE L29P FAMILY OF RIBOSOMAL PROTEINS. X2BFW6,O06050 No information pathways Rv0709 NC_002945.3 Mycobrowser_v2 CDS 807578 807988 . + 0 Mb0730 rpsQ 30s ribosomal protein s17 rpsq Mb0730, rpsQ, len: 136 aa. Equivalent to Rv0710,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Probable rpsQ, 30S ribosomal protein S17, equivalent to O06051|RS17_MYCBO 30S|MBS10OPER_11 30S RIBOSOMAL PROTEIN S17 from Mycobacterium bovis BCG (136 aa); and MLCB2492_11 30S RIBOSOMAL PROTEIN S17 from Mycobacterium leprae (126 aa). Also highly similar to others e.g. CAB82079.1|AL161803 30S ribosomal protein S17 from Streptomyces coelicolor (95 aa); P12874|RS17_BACSU 30s ribosomal protein s17 (bs 16) from Bacillus subtilis (86 aa), FASTA scores: opt: 305,E(): 1.6e-11, (60.5% identity in 81 aa overlap); etc. Contains PS00056 Ribosomal protein S17 signature. BELONGS TO THE S17P FAMILY OF RIBOSOMAL PROTEINS. X2BFY6,O06051 No information pathways Rv0710 NC_002945.3 Mycobrowser_v2 CDS 2194218 2194763 . + 0 Mb1992 HYPOTHETICAL PROTEIN Mb1992, -, len: 181 aa. Equivalent to Rv1957, len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Hypothetical unknown protein. Q7TZ75 No conserved hypotheticals Rv1957 NC_002945.3 Mycobrowser_v2 CDS 808610 810520 . + 0 Mb0732 atsAb POSSIBLE ARYLSULFATASE ATSAb [SECOND PART] (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE) Mb0732, atsAb, len: 636 aa. Equivalent to 3' end of Rv0711, len: 787 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 636 aa overlap). Possible atsA, arylsulfatase (EC 3.1.6.1), similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439,E(): 2.9e-21, (30.8% identity in 552 aa overlap); etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases signature 1, and PS00149 Sulfatases signature 2. BELONGS TO THE SULFATASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t),introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb. Q7U1F2 No NC_002945.3 Mycobrowser_v2 CDS 810568 811467 . + 0 Mb0733 conserved protein Mb0733, -, len: 299 aa. Equivalent to Rv0712, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Conserved hypothetical protein, similar to others e.g. NP_106128.1|NC_002678 hypothetical protein from Mesorhizobium loti (372 aa); D90901_33|P72841 HYPOTHETICAL 48.1 KD PROTEIN from Synechocystis sp (410 aa), FASTA scores: E(): 1.1e-07, (28.8% identity in 299 aa overlap); etc. Slight similarity to carboxykinases. Similar to C-terminal part of Rv3703c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (425 aa). Q7U1F1 No conserved hypotheticals Rv0712 NC_002945.3 Mycobrowser_v2 CDS 811768 812709 . + 0 Mb0734 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0734, -, len: 313 aa. Equivalent to Rv0713, len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 313 aa overlap). Probable conserved transmembrane protein, similar to Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis (284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35.8% identity in 282 aa overlap); MLCB2492_12|O32991 HYPOTHETICAL 10.7 KD PROTEIN from Mycobacterium leprae (95 aa). Q7U1F0 No cell wall and cell processes Rv0713 NC_002945.3 Mycobrowser_v2 CDS 813195 813563 . + 0 Mb0735 rplN 50s ribosomal protein l14 rpln Mb0735, rplN, len: 122 aa. Equivalent to Rv0714,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable rplN, 50S ribosomal protein L14, equivalent to O32993|MLCB2492_14|ML1849|RL14_MYCLE 50S RIBOSOMAL PROTEIN L14 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82080.1|AL161803 50S ribosomal protein L14 from Streptomyces coelicolor (122 aa); P33100|RL14_MICLU 50s ribosomal protein L14 from Micrococcus luteus (122 aa), FASTA scores: opt: 674, E(): 0, (85.2% identity in 122 aa overlap); etc. Contains PS00049 Ribosomal protein L14 signature. BELONGS TO THE L14P FAMILY OF RIBOSOMAL PROTEINS. X2BFZ2,P66070 No information pathways Rv0714 NC_002945.3 Mycobrowser_v2 CDS 815762 816130 . + 0 Mb0741 rplR 50s ribosomal protein l18 rplr Mb0741, rplR, len: 122 aa. Equivalent to Rv0720,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable rplR, 50S ribosomal protein L18, equivalent to O32999|MLCB2492_20|RL18_MYCLE 50S RIBOSOMAL PROTEIN L18 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82086.1|AL161803 50S ribosomal protein L18 from Streptomyces coelicolor (127 aa); P33102|RL18_MICLU 50s ribosomal protein L18 from Micrococcus luteus (119 aa), FASTA scores: opt: 447, E(): 8.7e-24, (60.4% identity in 111 aa overlap); etc. BELONGS TO THE L18P FAMILY OF RIBOSOMAL PROTEINS. X2BFY4,P66077 No information pathways Rv0720 NC_002945.3 Mycobrowser_v2 CDS 813564 813881 . + 0 Mb0736 rplX 50s ribosomal protein l24 rplx Mb0736, rplX, len: 105 aa. Equivalent to Rv0715,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Probable rplX, 50S ribosomal protein L24, equivalent to O32994|MLCB2492_15 50S RIBOSOMAL PROTEIN L24 from Mycobacterium leprae (105 aa). Also highly similar to others e.g. CAB82081.1|AL161803 50S ribosomal protein L24 from Streptomyces coelicolor (107 aa); P12876|RL24_BACSU 50s ribosomal protein L24 (bl23) from Bacillus subtilis (103 aa), FASTA scores: opt: 363, E(): 1.8e-18, (56.7% identity in 104 aa overlap); etc. Contains PS01108 Ribosomal protein L24 signature. BELONGS TO THE L24P FAMILY OF RIBOSOMAL PROTEINS. X2BFX8,P60628 No information pathways Rv0715 NC_002945.3 Mycobrowser_v2 CDS 813881 814444 . + 0 Mb0737 rplE 50s ribosomal protein l5 rple Mb0737, rplE, len: 187 aa. Equivalent to Rv0716,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable rplE, 50S ribosomal protein L5, equivalent to MLCB2492_16 50S RIBOSOMAL PROTEIN L5 from Mycobacterium leprae (187 aa). Also highly similar to others e.g. CAB82082.1|AL161803 50S ribosomal protein L5 from Streptomyces coelicolor (185 aa); P33098|RL5_MICLU 50S RIBOSOMAL PROTEIN L5 from Micrococcus luteus (191 aa), FASTA scores: opt: 930, E(): 0, (73.8% identity in 183 aa overlap); etc. BELONGS TO THE L5P FAMILY OF RIBOSOMAL PROTEINS. X2BFT0,P62402 No information pathways Rv0716 NC_002945.3 Mycobrowser_v2 CDS 814449 814634 . + 0 Mb0738 rpsN1 30s ribosomal protein s14 rpsn1 Mb0738, rpsN1, len: 61 aa. Equivalent to Rv0717,len: 61 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 61 aa overlap). Probable rpsN1, 30S ribosomal protein S14, equivalent to MLCB2492_17|O32996 RIBOSOMAL PROTEIN S14 from Mycobacterium leprae (61 aa). Also highly similar to others e.g. CAB82083.1|AL161803 30S ribosomal protein S14 from Streptomyces coelicolor (61 aa); P24320|RS14_THETH 30s ribosomal protein S14 from Thermus aquaticus (subsp. thermophilus) (60 aa), FASTA scores: opt: 316, E(): 2e-19,(70.0% identity in 60 aa overlap); etc. Contains PS00527 Ribosomal protein S14 signature. BELONGS TO THE S14P FAMILY OF RIBOSOMAL PROTEINS. Note that previously known as rpsN. X2BFS2,P0A5X3 No information pathways Rv0717 NC_002945.3 Mycobrowser_v2 CDS 814798 815196 . + 0 Mb0739 rpsH 30s ribosomal protein s8 rpsh Mb0739, rpsH, len: 132 aa. Equivalent to Rv0718,len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Probable rpsH, 30S ribosomal protein S8, equivalent to O32997|MLCB2492_18 30S RIBOSOMAL PROTEIN S8 from Mycobacterium leprae (132 aa). Also highly similar to others e.g. CAB82084.1|AL161803 30S ribosomal protein S8 from Streptomyces coelicolor (132 aa); P33106|RS8_MICLU 30s ribosomal protein S8 from Micrococcus luteus (132 aa), FASTA scores: opt: 669, E(): 0, (77.3% identity in 132 aa overlap); etc. Contains PS00053 Ribosomal protein S8 signature. BELONGS TO THE S8P FAMILY OF RIBOSOMAL PROTEINS. X2BFX6,P66626 No information pathways Rv0718 NC_002945.3 Mycobrowser_v2 CDS 815220 815759 . + 0 Mb0740 rplF 50s ribosomal protein l6 rplf Mb0740, rplF, len: 179 aa. Equivalent to Rv0719,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable rplF, 50S ribosomal protein L6, equivalent to O32998|MLCB2492_19 50S RIBOSOMAL PROTEIN L6 from Mycobacterium leprae (179 aa). Also highly similar to others e.g. P46786|RL6_STRCO|CAB82085.1|AL161803|SCD31.42 50S ribosomal protein L6 from Streptomyces coelicolor (179 aa), FASTA scores: opt: 872, E(): 0, (70.4% identity in 179 aa overlap); etc. Contains PS00525 Ribosomal protein L6 signature 1. BELONGS TO THE L6P FAMILY OF RIBOSOMAL PROTEINS. X2BFZ9,P66312 No information pathways Rv0719 NC_002945.3 Mycobrowser_v2 CDS 816150 816812 . + 0 Mb0742 rpsE 30s ribosomal protein s5 rpse Mb0742, rpsE, len: 220 aa. Equivalent to Rv0721,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable rpsE, 30S ribosomal protein S5, equivalent to MLCB2492_21 RIBOSOMAL PROTEIN S5 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. P46790|RS5_STRCO 30s ribosomal protein S5 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 889, E(): 0, (82.1% identity in 162 aa overlap); etc. Note N-terminus is extented compared to other rpsE genes. Contains PS00585 Ribosomal protein S5 signature, PTS HPr component phosphorylation sites signature. BELONGS TO THE S5P FAMILY OF RIBOSOMAL PROTEINS. X2BFT3,P66575 No information pathways Rv0721 NC_002945.3 Mycobrowser_v2 CDS 816815 817012 . + 0 Mb0743 rpmD 50s ribosomal protein l30 rpmd Mb0743, rpmD, len: 65 aa. Equivalent to Rv0722,len: 65 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 65 aa overlap). Probable rpmD, 50S ribosomal protein L30, equivalent to O33001 RIBOSOMAL PROTEIN L30 from Mycobacterium leprae (71 aa). Also highly similar to others e.g. P46789|RL30_STRCO 50S RIBOSOMAL PROTEIN L30 from Streptomyces coelicolor (60 aa); P02430|RL30_ECOLI 50S ribosomal protein L30 from Escherichia coli (58 aa), FASTA scores: opt: 168, E(): 1.5e-13, (53.7% identity in 54 aa overlap); etc. BELONGS TO THE L30P FAMILY OF RIBOSOMAL PROTEINS. X2BFS7,P66182 No information pathways Rv0722 NC_002945.3 Mycobrowser_v2 CDS 817012 817452 . + 0 Mb0744 rplO 50s ribosomal protein l15 rplo Mb0744, rplO, len: 146 aa. Equivalent to Rv0723,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Probable rplO, 50S ribosomal protein L15, equivalent to MLCB2492_23|O33002 50S RIBOSOMAL PROTEIN L15 from Mycobacterium leprae (146 aa). Also highly similar to others e.g. P46787|RL15_STRCO|SCD31.46 50S RIBOSOMAL PROTEIN L15 from Streptomyces coelicolor (151 aa); P19946|RL15_BACSU 50s ribosomal protein L15 from Bacillus subtilis (146 aa),FASTA scores: opt: 419, E(): 6.5e-20, (51.0% identity in 145 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00475 Ribosomal protein L15 signature. BELONGS TO THE L15P FAMILY OF RIBOSOMAL PROTEINS. X2BFY2,Q7U1E9 No information pathways Rv0723 NC_002945.3 Mycobrowser_v2 CDS 825505 826461 . - 0 Mb0752c possible s-adenosylmethionine-dependent methyltransferase Mb0752c, -, len: 318 aa. Equivalent to Rv0731c,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c|MTCY210.45c (367 aa), FASTA score: (60.9% identity in 317 aa overlap); Rv3399, Rv1729c, etc. X2BFU1,O53795 No lipid metabolism Rv0731c NC_002945.3 Mycobrowser_v2 CDS 817485 819356 . + 0 Mb0745 sppA POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) (SIGNAL PEPTIDE PEPTIDASE) Mb0745, sppA, len: 623 aa. Equivalent to Rv0724,len: 623 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 623 aa overlap). Possible sppA,protease IV (endopeptidase IV) (EC 3.4.21.-), equivalent (but longer 23 aa) to MLCB2492_24|O33003 ENDOPEPTIDASE IV from Mycobacterium leprae (602 aa). Also similar to others e.g. NP_419743.1|NC_002696 signal peptide peptidase SppA from Caulobacter crescentus (594 aa); P08395|SPPA_ECOLI|B1766 protease IV (endopeptidase) from Escherichia coli strain K-12 (618 aa), FASTA scores: opt: 582, E(): 8.9e-27, (34.1% identity in 525 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY S49. Q7U1E8 No cell wall and cell processes Rv0724 NC_002945.3 Mycobrowser_v2 CDS 820359 821462 . - 0 Mb0747c possible s-adenosylmethionine-dependent methyltransferase Mb0747c, -, len: 367 aa. Equivalent to Rv0726c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 367 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa),FASTA scores: opt: 646, E(): 0, (38.3% identity in 329 aa overlap); Rv0731c|MTV041.05c (318 aa), Rv3399, etc. Also similar to proteins from Mycobacterium leprae and other organisms e.g. T35930 hypothetical protein SC9B5.10 from Streptomyces coelicolor (303 aa). X2BFT7,Q7U1E6 No lipid metabolism Rv0726c NC_002945.3 Mycobrowser_v2 CDS 821665 822321 . - 0 Mb0748c fucA POSSIBLE L-FUCULOSE PHOSPHATE ALDOLASE FUCA (L-FUCULOSE-1-PHOSPHATE ALDOLASE) Mb0748c, fucA, len: 218 aa. Equivalent to Rv0727c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Possible fucA,L-fuculose-1-phosphate aldolase (EC 4.1.2.17), similar to many e.g. NP_386339.1|NC_003047 PUTATIVE L-FUCULOSE PHOSPHATE ALDOLASE PROTEIN from Sinorhizobium meliloti (222 aa); P11550|FUCA_ECOLI L-FUCULOSE PHOSPHATE ALDOLASE from Escherichia strain K12 (215 aa), FASTA scores: opt: 372, E(): 4.1e-19, (34.6% identity in 185 aa overlap); etc. BELONGS TO THE ALDOLASE CLASS II FAMILY, ARAD/FUCA SUBFAMILY. COFACTOR: BINDS ONE ZINC ION PER MOLECULE. Q7U1E5 No NC_002945.3 Mycobrowser_v2 CDS 822318 823298 . - 0 Mb0749c serA2 POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA2 (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH) Mb0749c, serA2, len: 326 aa. Equivalent to Rv0728c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 326 aa overlap). Possible serA2,D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95), similar to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (344 aa), FASTA scores: opt: 594, E(): 3.1e-31, (35.9% identity in 309 aa overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1 D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis (528 aa). Q7U1E4 No NC_002945.3 Mycobrowser_v2 CDS 823329 824675 . + 0 Mb0750 xylB POSSIBLE D-XYLULOSE KINASE XYLB (XYLULOKINASE) (XYLULOSE KINASE) Mb0750, xylB, len: 448 aa. Equivalent to Rv0729,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 448 aa overlap). Possible xylB,D-xylulose-kinase (xylulokinase) (EC 2.7.1.17). C-terminus highly similar to AAD09880.1|U77912 unknown protein from Mycobacterium bovis (102 aa); and N-terminus highly similar to T45387|Z98756|MLCB2492_25 hypothetical protein from Mycobacterium leprae (110 aa), FASTA scores: opt: 427, E(): 1.1e-19, (60.9% identity in 110 aa overlap). Also similar to xylA/xylB genes from various bacterial species e.g. AAC26499.1|AF045245 D-xylulose-kinase from Klebsiella pneumoniae (487 aa); NP_418021.1|NC_000913 xylulokinase from Escherichia coli strain K12 (484 aa),FASTA scores: opt: 260, E(): 7.5e-09, (25.9% identity in 478 aa overlap); etc. Also similar to Rv3696c|glpK PROBABLE GLYCEROL KINASE (EC 2.7.1.30) from Mycobacterium tuberculosis (517 aa). BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. Q7U1E3 No intermediary metabolism and respiration Rv0729 NC_002945.3 Mycobrowser_v2 CDS 1500676 1501116 . + 0 Mb1369 mec possible hydrolase Mb1369, -, len: 146 aa. Equivalent to Rv1334, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Conserved hypothetical protein, similar to AL096852|SCE19A_13 hypothetical protein from Streptomyces coelicolor (140 aa), Fasta scores: opt: 579, E(): 0, (65.0% identity in 140 aa overlap); and Q54330|M29166 MEC+ from Streptomyces kasugaensis (115 aa), FASTA scores; E(): 7.6e-33, (56.9% identity in 109 aa overlap). X2BHM6,P64814 No intermediary metabolism and respiration Rv1334 NC_002945.3 Mycobrowser_v2 CDS 826622 827947 . + 0 Mb0753 secY PROBABLE PREPROTEIN TRANSLOCASE SECY Mb0753, secY, len: 441 aa. Equivalent to Rv0732,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable SecY,preprotein translocase (integral membrane protein),equivalent to NP_302243.1|NC_002677 SecY subunit of preprotein translocase from Mycobacterium leprae (438 aa); AAC04389.1|AF047021 preprotein translocase subunit from Mycobacterium smegmatis (438 aa); and U77912|MBU77912_1 preprotein translocase subunit from Mycobacterium bovis (441 aa), FASTA scores: opt: 2802, E(): 0, (99.8% identity in 441 aa overlap). Also highly similar to others e.g. P46785|SECY_STRCO PREPROTEIN TRANSLOCASE SECY SUBUNIT from Streptomyces coelicolor (437 aa); etc. Contains PS00755 and PS00756 protein secY signatures 1 and 2. BELONGS TO THE SECE/SEC61-ALPHA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c,SECG|Rv1440 AND SECY. X2BFT9,P0A5Z3 No cell wall and cell processes Rv0732 NC_002945.3 Mycobrowser_v2 CDS 827944 828489 . + 0 Mb0754 adk adenylate kinase adk (atp-amp transphosphorylase) Mb0754, adk, len: 181 aa. Equivalent to Rv0733,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Probable adk,adenylate kinase (ATP-AMP transphosphorylase) (EC 2.7.4.3), equivalent to Z98756|MLCB24 92_28 probable adenylate kinase from Mycobacterium leprae (181 aa), FASTA scores: opt: 978, E(): 0, (83.6% identity in 177 aa overlap); and AAF86323.1|AF271342 putative adenylate kinase from Mycobacterium marinum (124 aa) (N-terminus shorter). Also highly similar to others e.g. P43414|KAD_STRCO ADENYLATE KINASE from Streptomyces coelicolor (217 aa), FASTA score: (43.0% identity in 186 aa overlap); etc. Contains PS00113 Adenylate kinase signature. BELONGS TO THE ADENYLATE KINASE FAMILY. X2BFZ4,P69439 No intermediary metabolism and respiration Rv0733 NC_002945.3 Mycobrowser_v2 CDS 828492 829292 . + 0 Mb0755 mapA methionine aminopeptidase mapa (map) (peptidase m) (metap) Mb0755, mapA, len: 266 aa. Equivalent to Rv0734,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable mapA,methionine aminopeptidase (map) (EC 3.4.11.18), equivalent to Z98756|MLCB2492_29 probable methionine aminopeptidase from Mycobacterium leprae (266 aa), FASTA scores: opt: 1717, E(): 0, (83.4% identity in 265 aa overlap). Also highly similar to many e.g. T35553 methionine aminopeptidase from Streptomyces coelicolor (278 aa); etc. Also similar to Rv2861c|MAPB PROBABLE METHIONINE AMINOPEPTIDASE from Mycobacterium tuberculosis (285 aa). BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT. O53797 No intermediary metabolism and respiration Rv0734 NC_002945.3 Mycobrowser_v2 CDS 829365 829898 . + 0 Mb0756 sigL PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGL Mb0756, sigL, len: 177 aa. Equivalent to Rv0735,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). Probable sigL,alternative RNA polymerase sigma factor (rpoE) (see citation below), highly similar to many proteins of the extracytoplasmatic function (ECF) subfamily e.g. CAB72200.1|AL138851 putative RNA polymerase sigma factor from Streptomyces coelicolor (194 aa); Q06909|CARQ_MYXXA RNA POLYMERASE SIGMA FACTOR CARQ from Myxococcus xanthus (174 aa), FASTA scores: opt: 251, E(): 9.6e-11, (32.9% identity in 161 aa overlap); etc. Also similar to MTCI61_4, MTU87242_1, and MLU15180_30 from Mycobacterium tuberculosis. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 139-160 (Score 1134, +3.05 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. O53798 No information pathways Rv0735 NC_002945.3 Mycobrowser_v2 CDS 829962 830714 . + 0 Mb0757 rsla anti-sigma factor rsla Mb0757, -, len: 250 aa. Equivalent to Rv0736, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Probable conserved membrane protein, showing weak similarity with AL133469|SCM10_32 putative membrane protein from Streptomyces coelicolor (216 aa), FASTA scores: opt: 180,E(): 0.00018, (34.3% identity in 216 aa overlap). O53799 No information pathways Rv0736 NC_002945.3 Mycobrowser_v2 CDS 831029 831526 . + 0 Mb0758 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0758, -, len: 165 aa. Equivalent to Rv0737, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Possible transcriptional regulator, similar to others e.g. BAB69161.1|AB070937 regulator protein from Streptomyces avermitilis (169 aa); NP_419731.1|NC_002696 transcriptional regulator MarR family from Caulobacter crescentus (148 aa) (homology only at C-terminus); etc. Also shows weak similarity to AB0014|AB001488_14 hypothetical protein from Bacillus subtilis (164 aa),FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in 116 aa overlap), which is similar to slyY gene of S. typhimurium required for survival in macrophage. Contains possible helix-turn helix motif from aa 73-94 (Score 1138,+3.06 SD). O53800 No regulatory proteins Rv0737 NC_002945.3 Mycobrowser_v2 CDS 831884 832432 . + 0 Mb0759 conserved protein Mb0759, -, len: 182 aa. Equivalent to Rv0738, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Conserved hypothetical protein, showing weak similarity with hypothetical proteins from Mycobacterium tuberculosis: Rv1727|MTCY04C12.12 (189 aa); MTY13D12_7|Z80343 hypothetical protein from Mycobacterium tuberculosis (194 aa), FASTA scores: opt: 172, E(): 0.0004, (24.2% identity in 178 aa overlap); and C-terminus of Rv0576. Q7U1E2 No conserved hypotheticals Rv0738 NC_002945.3 Mycobrowser_v2 CDS 832637 833485 . + 0 Mb0760 CONSERVED HYPOTHETICAL PROTEIN Mb0760, -, len: 282 aa. Equivalent to Rv0739, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Conserved hypothetical protein, showing some similarity to Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA score: (37.6% identity in 101 aa overlap)and Rv0025 (120 aa), FASTA score: (32.4% identity in 142 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2 bp insertion (*-cg) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa). Q7U1E1 No conserved hypotheticals Rv0739 NC_002945.3 Mycobrowser_v2 CDS 833600 834127 . + 0 Mb0761 CONSERVED HYPOTHETICAL PROTEIN Mb0761, -, len: 175 aa. Equivalent to Rv0740, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Conserved hypothetical protein; C-terminus (possibly part of truncated IS1557) shows nearly perfect identity to Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% identity in 81 aa overlap). Also shows weak similarity to MTV007_5 hypothetical protein from Mycobacterium tuberculosis (313 aa), FASTA score: (34.5% identity in 110 aa overlap); and MLCL536_27 hypothetical protein from Mycobacterium leprae (315 aa), FASTA score: (34.5% identity in 84 aa overlap). Q7U1E0 No conserved hypotheticals Rv0740 NC_002945.3 Mycobrowser_v2 CDS 834358 834672 . + 0 Mb0762 probable transposase (fragment) Mb0762, -, len: 104 aa. Equivalent to Rv0741, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable truncated transposase for IS1557, showing similarity to transposases and IS elements e.g. U63997|EFU63997_1 insertion sequence from Enterococcus faecium (424 aa), FASTA score: (31.0% identity in 87 aa overlap). Very high similarity with the C-terminal part of Z73419|MTCY373_3 2 IS1557 from Mycobacterium tuberculosis (444 aa), FASTA score: (86.5% identity in 104 aa overlap). Q7U1D9 No insertion seqs and phages Rv0741 NC_002945.3 Mycobrowser_v2 CDS 834814 835332 . + 0 Mb0763 PE_PGRS8 pe-pgrs family protein pe_pgrs8 Mb0763, PE_PGRS8, len: 172 aa. Equivalent to Rv0742, len: 172 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 172 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many M. tuberculosis PGRS-type proteins e.g. Z78020|MTCY1A11_25 (498 aa), FASTA scores: opt: 766, E(): 6.1e-25, (73.6% identity in 178 aa overlap). Similarity suggests ORF starts with ATA start codon. Q7U1D8 No PE/PPE Rv0742 NC_002945.3 Mycobrowser_v2 CDS 835710 836267 . - 0 Mb0764c HYPOTHETICAL PROTEIN Mb0764c, -, len: 185 aa. Equivalent to Rv0743c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Hypothetical unknown protein. Q7U1D7 No conserved hypotheticals Rv0743c NC_002945.3 Mycobrowser_v2 CDS 836264 836770 . - 0 Mb0765c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0765c, -, len: 168 aa. Equivalent to Rv0744c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Possible transcriptional regulator, showing weak similarity with O86661|SC4A2.05 PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (436 aa), FASTA scores: opt: 117,E(): 0.88, (37.25% identity in 94 aa overlap); and some putative excisionases or transposases. Also weakly similar to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (114 aa); and Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (148 aa). Equivalent to AAK45006 from Mycobacterium tuberculosis strain CDC1551 (179 aa) but shorter 11 aa. Contains probable helix-turn helix motif from aa 5-26 (Score 1350, +3.78 SD). Q7U1D6 No regulatory proteins Rv0744c NC_002945.3 Mycobrowser_v2 CDS 836978 837505 . + 0 Mb0766 CONSERVED HYPOTHETICAL PROTEIN Mb0766, -, len: 175 aa. Equivalent to Rv0745, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Conserved hypothetical protein; shows high similarity to a 50 aa region of Rv3649|Z95436|MTY15C10_3 CONSERVED HYPOTHETICAL PROTEIN, similar to ATP-dependent helicases, from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 225, E(): 7e-06, (70.0% identity in 50 aa overlap). Q7U1D5 No conserved hypotheticals Rv0745 NC_002945.3 Mycobrowser_v2 CDS 837525 839918 . + 0 Mb0767 PE_PGRS9 pe-pgrs family protein pe_pgrs9 Mb0767, PE_PGRS9, len: 797 aa. Equivalent to Rv0746, len: 783 aa, from Mycobacterium tuberculosis strain H37Rv, (89.7% identity in 829 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2429, E(): 0,(56.9% identity in 873 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. AL0212|MTV008_46 FASTA score: (48.8% identity in 887 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Q7U1D4 No PE/PPE Rv0746 NC_002945.3 Mycobrowser_v2 CDS 840317 843046 . + 0 Mb0768 PE_PGRS10 pe-pgrs family protein pe_pgrs10 Mb0768, PE_PGRS10, len: 909 aa. Equivalent to Rv0747, len: 801 aa, from Mycobacterium tuberculosis strain H37Rv, (86.6% identity in 912 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2772, E(): 0,(60.9% identity in 941 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. Z95844|MTCY493_2 FASTA score: (50.2% identity in 815 aa overlap). Contains PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (cggcaacgg-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa versus 801 aa). Q7U1D3 No NC_002945.3 Mycobrowser_v2 CDS 844537 845421 . - 0 Mb0773c mmsB PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH) Mb0773c, mmsB, len: 294 aa. Equivalent to Rv0751c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Probable mmsB,3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31), highly similar to others e.g. NP_102847.1|NC_002678 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti (294 aa); NP_420167.1|NC_002696 3-hydroxyisobutyrate dehydrogenase from Caulobacter crescentus (298 aa); A32867 3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus (346 aa); etc. Also similar to methylmalonate semialdehyde dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate semialdehyde dehydrogenase from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 786, E(): 0, (45.8% identity in 297 aa overlap). Also similar to 6-phosphogluconate dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. Contains PS00895 3-hydroxyisobutyrate dehydrogenase signature. BELONGS TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY. X2BFW4,P63936 No NC_002945.3 Mycobrowser_v2 CDS 845432 846604 . - 0 Mb0774c fadE9 PROBABLE ACYL-COA DEHYDROGENASE FADE9 Mb0774c, fadE9, len: 390 aa. Equivalent to Rv0752c,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 390 aa overlap). Probable fadE9,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. NP_437985.1|NC_003078 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (380 aa); Z99123|BSUB0020_14 from Bacillus subtilis (379 aa),FASTA scores: opt: 853, E(): 0, (39.8% identity in 384 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, and PS00073 Acyl-Co Adehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. Q7U1C8 No NC_002945.3 Mycobrowser_v2 CDS 871173 871952 . - 0 Mb0799c CONSERVED HYPOTHETICAL PROTEIN Mb0799c, -, len: 259 aa. Equivalent to Rv0776c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Conserved hypothetical protein, similar (except first 50 aa) to P72737|D90900_57 hypothetical protein from Synechocystis sp. strain PCC 6803 (261 aa), FASTA scores: opt: 337, E(): 1.7e-15, (30.5% identity in 266 aa overlap). Q7U1A9 No conserved hypotheticals Rv0776c NC_002945.3 Mycobrowser_v2 CDS 846611 848143 . - 0 Mb0775c mmsA PROBABLE METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE MMSA (METHYLMALONIC ACID SEMIALDEHYDE DEHYDROGENASE) (MMSDH) Mb0775c, mmsA, len: 510 aa. Equivalent to Rv0753c,len: 510 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 510 aa overlap). Probable mmsA,methylmalonic acid semialdehyde dehydrogenase (EC 1.2.1.27), highly similar to others e.g. NP_420115.1|NC_002696 putative methylmalonate-semialdehyde dehydrogenase from Caulobacter crescentus (499 aa); L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor (500 aa), FASTA score: (51.6% identity in 498 aa overlap); M84911|PSEMMSRAB_2|NP_252260.1|NC_002516 methylmalonate-semialdehyde dehydrogenase from Pseudomonas aeruginosa (497 aa), FASTA scores: opt: 1127, E(): 0,(47.9% identity in 507 aa overlap); etc. Note that also highly similar to malonic semialdehyde oxidative decarboxylases e.g. NP_104968.1|NC_002678 malonic semialdehyde oxidative decarboxylase from Mesorhizobium loti (498 aa); NP_384832.1|NC_003047 PUTATIVE MALONIC SEMIALDEHYDE OXIDATIVE DECARBOXYLASE PROTEIN from Sinorhizobium meliloti (498 aa); etc. Contains PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Q7U1C7 No NC_002945.3 Mycobrowser_v2 CDS 866329 866763 . + 0 Mb0794 POSSIBLE 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) Mb0794, -, len: 144 aa. Equivalent to Rv0771, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible 4-carboxymuconolactone decarboxylase (EC 4.1.1.44),showing similarity with other carboxymuconolactone decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein from Pseudomonas putida (130 aa); P20370|DC4C_ACICA 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) from Acinetobacter sp. ADP1 (134 aa), FASTA scores: opt: 174,E(): 0.00075, (31.4% identity in 121 aa overlap); C-terminus of NP_421214.1|NC_002696 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Caulobacter crescentus (393 aa); C-terminus of T47115 probable 4-carboxymuconolactone decarboxylase / 3-oxoadipate enol-lactone hydrolase from Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative gamma carboxymuconolactone decarboxylase from Yersinia pestis (131 aa); etc. Q7U1B3 No intermediary metabolism and respiration Rv0771 NC_002945.3 Mycobrowser_v2 CDS 854586 856043 . + 0 Mb0781 phoR POSSIBLE TWO COMPONENT SYSTEM RESPONSE SENSOR KINASE MEMBRANE ASSOCIATED PHOR Mb0781, phoR, len: 485 aa. Equivalent to Rv0758,len: 485 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 485 aa overlap). Possible phoR, two component system response phosphate sensor kinase membrane-associated (EC 2.7.-.-), highly similar to various sensor kinases e.g. CAC32361.1|AL583945 putative two component system histidine kinase from Streptomyces coelicolor (524 aa); NP_349365.1|NC_003030 Membrane-associated sensory histidine kinase with HAMP domain from Clostridium acetobutylicum (482 aa); and similar to phoP proteins e.g. NP_372216.1|NC_002758 alkaline phosphatase synthesis sensor protein from Staphylococcus aureus (554 aa); P23545|PHOR_BACSU alkaline phosphatase synthesis sensor from Bacillus subtilis (579 aa), FASTA scores: opt: 515, E(): 1.9e-25, (40.0% identity in 230 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. MTCY20G9.16 FASTA scores: (34.5% identity in 264 aa overlap), MTU88959_2 (509 aa),MTCY10G2_17, etc. Q7U1C1 No regulatory proteins Rv0758 NC_002945.3 Mycobrowser_v2 CDS 848349 850103 . + 0 Mb0776 PE_PGRS11 pe-pgrs family protein pe_pgrs11 Mb0776, PE_PGRS11, len: 584 aa. Equivalent to Rv0754, len: 584 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 584 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. AL0212|MTV008_46 from Mycobacterium tuberculosis (1660 aa), FASTA score: (48.7% identity in 345 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa),FASTA score: (41.6% identity in 442 aa overlap); etc. Q7U1C6 No NC_002945.3 Mycobrowser_v2 CDS 850293 852230 . - 0 Mb0777c PPE12 ppe family protein ppe12 Mb0777c, PPE12, len: 645 aa. Equivalent to Rv0755c,len: 645 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 645 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to others e.g. Z82098|MTCY3C7_23 from Mycobacterium tuberculosis (582 aa), FASTA scores: (56.1% identity in 636 aa overlap); Z92774|MTCY6G11_5 from Mycobacterium tuberculosis (552 aa), FASTA scores: (55.8% identity in 590 aa overlap); etc. Q7U1C5 No NC_002945.3 Mycobrowser_v2 CDS 852532 852717 . - 0 Mb0778c PUTATIVE TRANSPOSASE (FRAGMENT) Mb0778c, -, len: 61 aa. Equivalent to Rv0755A, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 61 aa overlap). Putative transposase (possibly gene fragment), similar to C-terminal part of Q9EZM2|ISMav2|AF286339_1 putative transposase from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 284, E(): 5e-13, (83.02% identity in 53 aa overlap); and to SCJ11.25c|Q9RI80 possible noncomposite transposon transposase from Streptomyces coelicolor (283 aa). Q7U1C4 No insertion seqs and phages Rv0755A NC_002945.3 Mycobrowser_v2 CDS 852931 853656 . - 0 Mb0779c unknown protein Mb0779c, -, len: 241 aa. Equivalent to Rv0756c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Hypothetical unknown protein. Q7U1C3 No conserved hypotheticals Rv0756c NC_002945.3 Mycobrowser_v2 CDS 1501138 1501419 . + 0 Mb1370 cyso sulfur carrier protein cyso Mb1370, -, len: 93 aa. Equivalent to Rv1335, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 93 aa overlap). 9.5 kDa culture filtrate antigen cfp10A (see citation below). Similar to hypothetical proteins from other organisms e.g. P74060|D90911 Synechocystis (109 aa), FASTA scores: E(): 2.3e-20, (49.5% identity in 93 aa overlap). X2BHE1,P0A647 No intermediary metabolism and respiration Rv1335 NC_002945.3 Mycobrowser_v2 CDS 853798 854541 . + 0 Mb0780 phoP POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP Mb0780, phoP, len: 247 aa. Equivalent to Rv0757,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Possible phoP, two component system response phosphate regulon transcriptional regulator, highly similar to various transcriptional regulators e.g. CAC32360.1|AL583945 putative two component system response regulator from Streptomyces coelicolor (271 aa); T45446 probable two-component response regulator from Mycobacterium leprae (253 aa); and similar to phoP proteins e.g. P13792|PHOP_BACSU alkaline phosphatase synthesis transcription regulatory protein from Bacillus subtilis (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, (41.0% identity in 234 aa overlap); etc. Also highly similar to Rv3765c from Mycobacterium tuberculosis (234 aa), Rv1033c (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa), FASTA score: (45.4% identity in 229 aa overlap); MTCY10G2_16 and MTU88959_1. Q7U1C2 No regulatory proteins Rv0757 NC_002945.3 Mycobrowser_v2 CDS 856015 856347 . - 0 Mb0782c CONSERVED HYPOTHETICAL PROTEIN Mb0782c, -, len: 110 aa. Equivalent to Rv0759c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Conserved hypothetical protein, highly similar (but shorter 45 aa in N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A HYPOTHETICAL HIT-LIKE PROTEIN from Mycobacterium leprae (155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity in 150 aa overlap). Also highly similar (but N-terminus always shorter) to HIT-like proteins and protein kinase inhibitors e.g. AAF72728.1|AF265258_1|AF265258 HIT-like protein from Rhodococcus sp. (141 aa); NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI) from Borrelia burgdorferi (149 aa) ; P94252|YHIT_BORBU|BB0379 HYPOTHETICAL HIT-LIKE PROTEIN from Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689 HIT (histidine triad) family protein from Thermoplasma volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa),FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity in 111 aa overlap); etc. Also shows similarity with Rv2613c|MTCY01A10.20A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20 HYPOTHETICAL HIT-LIKE PROTEIN (144 aa). X2BFV7,P0A5B6 No conserved hypotheticals Rv0759c NC_002945.3 Mycobrowser_v2 CDS 856456 856875 . - 0 Mb0783c conserved protein Mb0783c, -, len: 139 aa. Equivalent to Rv0760c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, similar to N-terminal part of Rv2042c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (265 aa), FASTA scores: opt: 150, E(): 4.1e-05, (28.7% identity in 136 aa overlap). Q7U1C0 No conserved hypotheticals Rv0760c NC_002945.3 Mycobrowser_v2 CDS 856888 858015 . - 0 Mb0784c adhB possible zinc-containing alcohol dehydrogenase nad dependent adhb Mb0784c, adhB, len: 375 aa. Equivalent to Rv0761c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Possible adhB,zinc-containing alcohol dehydrogenase NAD-dependant (EC 1.1.1.1), similar to others e.g. AAC15839.1|AF060871_4 hypothetical alcohol dehydrogenase from Rhodococcus rhodochrous (370 aa), FASTA scores: opt: 1234, E(): 0,(46.8% identity in 370 aa overlap); P80468|ADH2_STRCA ALCOHOL DEHYDROGENASE II from Struthio camelus (Ostrich) (379 aa); Q03505|ADH1_RABIT alcohol dehydrogenase alpha chain from Oryctolagus cuniculus (Rabbit) (374 aa), FASTA scores: opt: 872, E(): 0, (39.1% identity in 379 aa overlap); etc. Also similar to adhD alcohol dehydrogenase from Mycobacterium tuberculosis (368 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY. X2BG32,Q7U1B9 No NC_002945.3 Mycobrowser_v2 CDS 858114 858659 . - 0 Mb0785c CONSERVED HYPOTHETICAL PROTEIN Mb0785c, -, len: 181 aa. Equivalent to Rv0762c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Conserved hypothetical protein, showing weak similarity to D90907_77|P73575 HYPOTHETICAL 31.3KD PROTEIN from Synechocystis sp, FASTA scores: E(): 0.0012, (30.4% identity in 92 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U1B8 No conserved hypotheticals Rv0762c NC_002945.3 Mycobrowser_v2 CDS 858662 858868 . - 0 Mb0786c POSSIBLE FERREDOXIN Mb0786c, -, len: 68 aa. Equivalent to Rv0763c, len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Possible ferredoxin,similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c PROBABLE CYTOCHROME P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 137, E(): 0.00013, (36.4% identity in 66 aa overlap). Also similar to putative ferredoxins Rv3503c and Rv1786 from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY. Q7U1B7 No intermediary metabolism and respiration Rv0763c NC_002945.3 Mycobrowser_v2 CDS 910860 911672 . - 0 Mb0840c PROBABLE CONSERVED EXPORTED PROTEIN Mb0840c, -, len: 270 aa. Equivalent to Rv0817c,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Probable conserved exported protein, with N-terminal signal sequence,equivalent (but shorter 13 aa) to U15182|MLU15182_22|U2266M probable exported protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1287,E(): 0, (73.0% identity in 270 aa overlap). Q7U175 No cell wall and cell processes Rv0817c NC_002945.3 Mycobrowser_v2 CDS 858871 860226 . - 0 Mb0787c cyp51 CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM) Mb0787c, cyp51, len: 451 aa. Equivalent to Rv0764c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). cyp51, cytochrome P450 51 (sterol 14-alpha demethylase) (EC 1.14.14.-),similar to others e.g. Q16850|CP51_HUMAN CYTOCHROME P450 51 (CYPL1) (P450L1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Homo sapiens (509 aa), FASTA scores: opt: 848, E(): 0, (33.9% identity in 439 aa overlap); NP_172633.1|NC_003070 putative obtusifoliol 14-alpha demethylase from Arabidopsis thaliana (488 aa); P93596|CP51_WHEAT CYTOCHROME P450 51 (CYPL1) (P450-L1A1) (OBTUSIFOLIOL 14-ALPHA DEMETHYLASE) from Triticum aestivum (453 aa); etc. Also similar to many other Mycobacterium tuberculosis cytochromes P450 e.g. Rv1394c, FASTA score: (22.5% identity in 444 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BFW1,P0A513 No NC_002945.3 Mycobrowser_v2 CDS 860226 861053 . - 0 Mb0788c PROBABLE OXIDOREDUCTASE Mb0788c, -, len: 275 aa. Equivalent to Rv0765c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar others e.g. P39071|DHBA_BACSU 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Bacillus subtilis (261 aa), FASTA scores: opt: 385, E(): 1.8e-17, (30.6% identity in 252 aa overlap); AAF81239.1|AF263012 putative beta-ketoacyl reductase from Streptomyces griseus (274 aa); NP_436514.1|NC_003037 putative oxidoreductase from Sinorhizobium meliloti (240 aa); etc. Also similar to several other oxidoreductases from Mycobacterium tuberculosis e.g. Rv1544|MTCY48.21, FASTA score: (32.6% identity in 267 aa overlap); etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. Q7U1B6 No intermediary metabolism and respiration Rv0765c NC_002945.3 Mycobrowser_v2 CDS 861053 862261 . - 0 Mb0789c cyp123 PROBABLE CYTOCHROME P450 123 CYP123 Mb0789c, cyp123, len: 402 aa. Equivalent to Rv0766c, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 402 aa overlap). Probable cyp123, cytochrome P-450 (EC 1.14.-.-), similar to others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 from Saccharopolyspora erythraea (405 aa), FASTA scores: opt: 770, E(): 0, (36.9% identity in 406 aa overlap); T36526 probable cytochrome P450 hydroxylase from Streptomyces coelicolor (411 aa); P27632|CPXM_BACSU CYTOCHROME P450 109 from Bacillus subtilis (405 aa); etc. Also similar to several other cytochromes P-450 from Mycobacterium tuberculosis e.g. Rv1256c|MTCY50.26 (405 aa), FASTA score: (35.2% identity in 389 aa overlap); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. X2BG36,P63708 No intermediary metabolism and respiration Rv0766c NC_002945.3 Mycobrowser_v2 CDS 862258 862899 . - 0 Mb0790c CONSERVED HYPOTHETICAL PROTEIN Mb0790c, -, len: 213 aa. Equivalent to Rv0767c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, showing weak similarity with AL133220|SCC75A_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (215 aa), FASTA scores: opt: 152, E(): 0.0048,(28.4% identity in 204 aa overlap). X2BG56,P67433 No conserved hypotheticals Rv0767c NC_002945.3 Mycobrowser_v2 CDS 863101 864570 . + 0 Mb0791 aldA probable aldehyde dehydrogenase nad dependent alda (aldehyde dehydrogenase [nad+]) Mb0791, aldA, len: 489 aa. Equivalent to Rv0768,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 489 aa overlap). Probable aldA,NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid dehydrogenase from Rhodococcus ruber (474 aa); NP_285450.1|NC_001264 aldehyde dehydrogenase from Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570 NADP-dependent aldehyde dehydrogenase from Bacillus halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde dehydrogenase precursor from Atriplex hortensis (Mountain spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6% identity in 486 aa overlap); etc. Also highly similar to Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium tuberculosis (487 aa). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Q7TTS0 No intermediary metabolism and respiration Rv0768 NC_002945.3 Mycobrowser_v2 CDS 864601 865347 . + 0 Mb0792 PROBABLE DEHYDROGENASE/REDUCTASE Mb0792, -, len: 248 aa. Equivalent to Rv0769, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 248 aa overlap). Probable dehydrogenase/reductase (EC 1.-.-.-), similar to others,especially short-chain type dehydrogenases/reductases and 3-oxoacyl-(acyl-carrier protein) reductases e.g. NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa); NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein) reductase from Bacillus halodurans (246 aa); P28643|FABG_CUPLA 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Cuphea lanceolata (320 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 536,E(): 6.5e-27, (37.7% identity in 247 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. MTCY02B10.14, FASTA score: (33.7% identity in 249 aa overlap); etc. Q7U1B5 No intermediary metabolism and respiration Rv0769 NC_002945.3 Mycobrowser_v2 CDS 865445 866332 . + 0 Mb0793 PROBABLE DEHYDROGENASE/REDUCTASE Mb0793, -, len: 295 aa. Equivalent to Rv0770, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable dehydrogenase/reductase, 3-hydroxyisobutyrate dehydrogenase family (EC 1.1.1.-), possibly 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) or 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60), similar to others e.g. P23523|GARR_ECOLI 2-HYDROXY-3-OXOPROPIONATE REDUCTASE (TARTRONATE SEMIALDEHYDE REDUCTASE) (TSAR) from Escherichia coli strain K12 (294 aa), FASTA scores: opt: 469, E(): 6.7e-22, (34.4% identity in 282 aa overlap); P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase (HIBADH) from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 439, E(): 4.3e-20, (34.9% identity in 269 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. SEEMS TO BELONG TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY. Q7U1B4 No intermediary metabolism and respiration Rv0770 NC_002945.3 Mycobrowser_v2 CDS 866775 868043 . + 0 Mb0795 purD PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) Mb0795, purD, len: 422 aa. Equivalent to Rv0772,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Probable purD,phosphoribosylamine--glycine ligase (EC 6.3.4.13),equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08 PHOSPHORIBOSYLAMINE--GLYCINE LIGASE from Mycobacterium leprae (422 aa), FASTA scores: opt: 2272, E(): 0, (81.8% identity in 422 aa overlap). Also highly similar to others e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine ligase from Streptomyces coelicolor (416 aa); P1564|PUR2_ECOLI phosphoribosylamine--glycine ligase from Escherichia coli (429 aa), FASTA scores: opt: 1039, E(): 0, (42.7% identity in 431 aa overlap); etc. BELONGS TO THE GARS FAMILY. X2BG60,P65894 No intermediary metabolism and respiration Rv0772 NC_002945.3 Mycobrowser_v2 CDS 868040 869578 . - 0 Mb0796c ggtA PROBABLE BIFUNCTIONAL ACYLASE GGTA: CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE) + GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT) Mb0796c, ggtA, len: 512 aa. Equivalent to Rv0773c,len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Probable ggtA,bifunctional acylase including cephalosporin acylase (EC 3.5.1.-), and gamma-glutamyl transpeptidase (EC 2.3.2.2); highly similar to others e.g. NP_295247.1|NC_001263 cephalosporin acylase from Deinococcus radiodurans (535 aa); NP_248854.1|NC_002516 probable gamma-glutamyltranspeptidase from Pseudomonas aeruginosa (538 aa); P15557|PAC1_PSES3 ACYLASE ACY 1 [INCLUDES: CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE); GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)] from Pseudomonas sp. strain SE83 (558 aa), FASTA scores: opt: 784, E(): 0,(34.2% identity in 526 aa overlap); NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein similar to gamma-glutamyltransferase from Bacillus subtilis (525 aa), FASTA scores: opt: 1169, E(): 0, (40.1% identity in 516 aa overlap); etc. Also similar to Rv2394|ggtB from Mycobacterium tuberculosis. Member of GL-7ACA ACYLASES AND TO GGT group. Q7U1B2 No NC_002945.3 Mycobrowser_v2 CDS 869629 870540 . - 0 Mb0797c PROBABLE CONSERVED EXPORTED PROTEIN Mb0797c, -, len: 303 aa. Equivalent to Rv0774c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 303 aa overlap). Possible conserved exported protein with hydrophobic region near N-terminus,highly similar, except in N-terminus, to Rv0519c|Z97831|MTY20G10.09c|O33364 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (300 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature, and PS00120 Lipases, serine active site. So could be a lipase (EC 3.1.-.-). Q7U1B1 No cell wall and cell processes Rv0774c NC_002945.3 Mycobrowser_v2 CDS 870596 871219 . + 0 Mb0798 CONSERVED HYPOTHETICAL PROTEIN Mb0798, -, len: 207 aa. Equivalent to Rv0775, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins e.g. ECAE000186_11|MG1655 HYPOTHETICAL PROTEIN from Escherichia coli strain K-12 (178 aa), FASTA scores: E(): 6.4e-05, (27.2% identity in 147 aa overlap); P41037|BIH_ECOLI hypothetical transcriptional regulator from Escherichia coli (103 aa), FASTA scores: opt: 138,E(): 0.003, (30.9% identity in 97 aa overlap); etc. Q7U1B0 No conserved hypotheticals Rv0775 NC_002945.3 Mycobrowser_v2 CDS 892302 893099 . - 0 Mb0821c cfp29 29 KDa ANTIGEN CFP29 Mb0821c, cfp29, len: 265 aa. Equivalent to Rv0798c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). cfp29, 29 kDa antigen (see citations below). Highly similar to Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from Brevibacterium linens (266 aa), FASTA scores: (58.5% identity in 265 aa overlap). Also shows similarity with NP_228594.1|NC_000853 bacteriocin from Thermotoga maritima (262 aa). Q7U190 No NC_002945.3 Mycobrowser_v2 CDS 872197 873615 . + 0 Mb0800 purB PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) (ASL) (ASASE) Mb0800, purB, len: 472 aa. Equivalent to Rv0777,len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable purB,adenylosuccinate lyase (EC 4.3.2.2), equivalent (but shorter 15 aa) to MLCB5.13|Z95151|g2076607|PURB ADENYLOSUCCINATE LYASE from Mycobacterium leprae (487 aa),FASTA scores: opt: 2640, E(): 0, (86.7% identity in 472 aa overlap). More similar to eukaryotic adenylosuccinate lyases than to prokaryotic adenylosuccinate lyases e.g. P54822|PUR8_MOUSE ADENYLOSUCCINATE LYASE from Mus musculus (484 aa), FASTA scores: opt: 762, E(): 0, (32.4% identity in 445 aa overlap); CAB99134.1|AL390188 putative adenylosuccino lyase (fragment) from Streptomyces coelicolor (362 aa); etc. Contains PS00163 Fumarate lyases signature. BELONGS TO THE LYASE 1 FAMILY, ADENYLOSSUCINATE LYASE SUBFAMILY. Q7U1A8 No intermediary metabolism and respiration Rv0777 NC_002945.3 Mycobrowser_v2 CDS 882124 883230 . + 0 Mb0808 CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] Mb0808, -, len: 368 aa. Equivalent to 3' end of Rv0785, len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 368 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 from Deinococcus radiodurans (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FASTA scores: opt: 169, E(): 0.0014,(23.8% identity in 542 aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% identity in 587 aa overlap). And shows similarity with other dehydrogenases. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808. Q7U1A2 No NC_002945.3 Mycobrowser_v2 CDS 873620 874864 . + 0 Mb0801 cyp126 POSSIBLE CYTOCHROME P450 126 CYP126 Mb0801, cyp126, len: 414 aa. Equivalent to Rv0778,len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Possible cyp126,cytochrome P-450 (EC 1.14.-.-), similar to other cytochromes and related proteins e.g. AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1 cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28) (lin C) from Pseudomonas incognita (406 aa), FASTA scores: opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. X2BG53,P63712 No NC_002945.3 Mycobrowser_v2 CDS 874861 875481 . - 0 Mb0802c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0802c, -, len: 206 aa. Equivalent to Rv0779c,len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Possible conserved transmembrane protein, equivalent to Z95151|MLCB5_14 O05747 conserved hypothetical protein from Mycobacterium leprae (206 aa), FASTA scores: opt: 902, E(): 0, (67.2% identity in 204 aa overlap). Q7U1A7 No cell wall and cell processes Rv0779c NC_002945.3 Mycobrowser_v2 CDS 888027 888836 . - 0 Mb0816c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) Mb0816c, -, len: 269 aa. Equivalent to Rv0792c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 269 aa overlap). Probable transcriptional regulator, GntR-family, similar to many others of GntR family e.g. BSUB0018_189|Z99121 from Bacillus subtilis (243 aa), FASTA scores: opt: 367, E(): 1.5e-17, (32.1% identity in 246 aa overlap); P31453|YIDP_ECOLI from Escherichia coli (238 aa), FASTA scores: opt: 236, E(): 8.8e-09, (26.4% identity in 235 aa overlap); etc. Q7U195 No regulatory proteins Rv0792c NC_002945.3 Mycobrowser_v2 CDS 875532 876425 . + 0 Mb0803 purC PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE PURC (SAICAR SYNTHETASE) Mb0803, purC, len: 297 aa. Equivalent to Rv0780,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 297 aa overlap). purC,phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (see citations below), equivalent to MTU34957_1|PURC phosphoribosylaminoimidazole-succinocarboxamide synthase from Mycobacterium leprae (297 aa), FASTA scores: opt: 1986, E(): 0, (99.3% identity in 297 aa overlap). Also similar to others e.g. CAB56351.1|AL118514 phosphoribosylaminoimidazole-succinocarboxamide synthase from Streptomyces coelicolor (299 aa); etc. Contains PS01058 SAICAR synthetase signature 2. BELONGS TO THE SAICAR SYNTHETASE FAMILY. X2BG03,P0A5T5 No intermediary metabolism and respiration Rv0780 NC_002945.3 Mycobrowser_v2 CDS 876422 878581 . + 0 Mb0804 ptrB probable protease ii ptrbb [second part] (oligopeptidase b) Mb0804, ptrB, len: 719 aa. Equivalent to Rv0781 and Rv0782, len: 236 aa and 552 aa, from Mycobacterium tuberculosis strain H37Rv, (97.6% identity in 206 aa overlap and 100.0% identity in 517 aa overlap). Probable ptrB, protease II (EC 3.4.21.83), equivalent to NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to C-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa),FASTA scores: opt: 204, E(): 7.4e-07, (29.6% identity in 230 aa overlap); etc. Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa), FASTA scores: opt: 1251, E(): 0, (42.7% identity in 489 aa overlap); etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II, but we can find no error in the cosmid sequence to account for this. BELONGS TO PEPTIDASE FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. Note that previously known as ptrBb. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes,ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis, a 2 bp insertion (*-gc) leads to a single product. Q7U1A6 No intermediary metabolism and respiration Rv0781 NC_002945.3 Mycobrowser_v2 CDS 883265 883903 . - 0 Mb0809c conserved protein Mb0809c, -, len: 212 aa, equivalent to hypothetical protein MT0810 from Mycobacterium tuberculosis strain CDC1551, len: 212 aa (100% identity with 212 aa overlap). Mb0809c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BG57 No NC_002945.3 Mycobrowser_v2 CDS 884950 885624 . + 0 Mb0812 purQ PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I PURG (FGAM SYNTHASE I) Mb0812, purQ, len: 224 aa. Equivalent to Rv0788,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable purQ,phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3),equivalent to MLCB5_24|Z95151|O05756|PURQ PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from Mycobacterium leprae (224 aa), FASTA scores: opt: 1341,E(): 0, (88.7% identity in 222 aa overlap). Also highly similar to others e.g. P12041|PURQ_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from Bacillus subtilis (227 aa), FASTA scores: opt: 691, E(): 8.6e-39,(47.7% identity in 214 aa overlap); etc. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO TYPE-1 GLUTAMINE AMIDOTRANSFERASES. X2BFY1,P65903 No intermediary metabolism and respiration Rv0788 NC_002945.3 Mycobrowser_v2 tRNA 924940 925013 . + 0 aspT aspT tRNA-Asp aspT, len: 74 nt. Equivalent to aspT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Asp, anticodon gtc. No NC_002945.3 Mycobrowser_v2 tRNA 925043 925116 . + 0 pheU pheU tRNA-Phe pheU, len: 74 nt. Equivalent to pheU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Phe, anticodon gaa. No NC_002945.3 Mycobrowser_v2 CDS 879009 880631 . - 0 Mb0805c emrB POSSIBLE MULTIDRUG RESISTANCE INTEGRAL MEMBRANE EFFLUX PROTEIN EMRB Mb0805c, emrB, len: 540 aa. Equivalent to Rv0783c,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). Possible emrB,integral membrane drug efflux protein, member of major facilitator superfamily (MFS), equivalent to AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from Mycobacterium avium (538 aa). Also similar to other membrane proteins e.g. CAB61606.1|AL133210 putative export protein from Streptomyces coelicolor (496 aa); NP_108371.1|NC_002678 efflux pump protein FarB from Mesorhizobium loti (511 aa); P44927|EMRB_HAEINHI0897| multidrug resistance protein b homologue from Haemophilus influenzae (510 aa), FASTA scores: opt: 706, E(): 1.3e-36,(30.4% identity in 408 aa overlap); etc. Also similar to Rv2333c|MTCY3G12.01 from Mycobacterium tuberculosis (537 aa), FASTA score: (28.2% identity in 408 aa overlap); and Rv1410c|MTCY21B4.27c from Mycobacterium tuberculosis (518 aa), FASTA score: (26.8% identity in 496 aa overlap). BELONGS TO THE MAJOR FACILITATOR FAMILY; ALSO KNOWN AS THE DRUG RESISTANCE TRANSLOCASE FAMILY. Q7U1A5 No NC_002945.3 Mycobrowser_v2 CDS 880829 881515 . + 0 Mb0806 CONSERVED HYPOTHETICAL PROTEIN Mb0806, -, len: 228 aa. Equivalent to Rv0784, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Conserved hypothetical protein, with some similarity to MLCB5_20|O05752 hypothetical protein from Mycobacterium leprae (193 aa), FASTA scores: opt: 141, E(): 0.0022,(36.0% identity in 114 aa overlap). Also similar to N-terminus of NP_253002.1|NC_002516 conserved hypothetical protein from Pseudomonas aeruginosa (253 aa). Q7U1A4 No conserved hypotheticals Rv0784 NC_002945.3 Mycobrowser_v2 CDS 881531 882106 . + 0 Mb0807 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] Mb0807, -, len: 191 aa. Equivalent to 5' end of Rv0785, len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, (97.1% identity in 140 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 from Deinococcus radiodurans (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FASTA scores: opt: 169, E(): 0.0014,(23.8% identity in 542 aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% identity in 587 aa overlap). And shows similarity with other dehydrogenases. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808. Q7U1A3 No NC_002945.3 Mycobrowser_v2 CDS 884714 884953 . + 0 Mb0811 conserved protein Mb0811, -, len: 79 aa. Equivalent to Rv0787A, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, equivalent to MLCB5.24 HYPOTHETICAL PROTEIN from Mycobacterium leprae (79 aa), FASTA scores: opt: 434,(84.8% identity in 79 aa overlap). Also similar to P12049|YEXA_BACSU HYPOTHETICAL 9.7 KD PROTEIN from Bacillus subtilis (84 aa), FASTA scores: opt: 172, E(): 4e-06, (44.4% identity in 72 aa overlap). BELONGS TO THE UPF0062 FAMILY. Q7U199 No conserved hypotheticals Rv0787A NC_002945.3 Mycobrowser_v2 CDS 886987 888030 . - 0 Mb0815c conserved protein Mb0815c, -, len: 347 aa. Equivalent to Rv0791c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Conserved hypothetical protein, similar (except in N-terminus) to others e.g. CAC44585.1|AL596162 conserved hypothetical protein from Streptomyces coelicolor (307 aa); NP_252643.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (364 aa); etc. Also some similarity with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); etc. And also similar in part to other proteins from Mycobacterium tuberculosis e.g. Rv1855c|MTCY359.18|Z83859 (307 aa), FASTA scores: opt: 366, E(): 4e-16, (35.0% identity in 226 aa overlap); Rv3079c|MTCY22D7.02|Z83866 CONSERVED HYPOTHETICAL PROTEIN (275 aa), FASTA scores: opt: 342, E(): 1.2e-14, (31.6% identity in 234 aa overlap); Rv0044c POSSIBLE OXIDOREDUCTASE (264 aa). Q7U196 No conserved hypotheticals Rv0791c NC_002945.3 Mycobrowser_v2 CDS 888909 889214 . + 0 Mb0817 possible monooxygenase Mb0817, -, len: 101 aa. Equivalent to Rv0793, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Conserved hypothetical protein, similar to others e.g. NP_250888.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (114 aa); AE 001908|AE001908_7 hypothetical protein from Deinococcus radiodurans (101 aa), FASTA scores: opt: 215, E(): 3.1e-09, (40.4% identity in 99 aa overlap); NP_440966.1|NC_000911|D90908|PCC6803|D90908_2 unknown protein from Synechocystis sp. strain PCC 6803 (147 aa),FASTA scores: opt: 194, E(): 4.5e-08, (31.1% identity in 90 aa overlap); etc. Also similar to Rv2749|MTV002.14|AL0089|MTV002_15 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 143, E(): 0.00026, (26.9% identity in 93 aa overlap). Q7U194 No intermediary metabolism and respiration Rv0793 NC_002945.3 Mycobrowser_v2 CDS 889327 889938 . - 0 Mb0818c PROBABLE OXIDOREDUCTASE [SECOND PART] Mb0818c, -, len: 203 aa. Equivalent to 3' end of Rv0794c, len: 499 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 203 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa); and similar to various oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa); NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase, similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa); Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Haloferax volcanii (475 aa); P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity in 467 aa overlap); P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa overlap); etc. Note that previously known as lpdB. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Mb0818c into 2 parts, Mb0818 and Mb0819. Q7U193 No NC_002945.3 Mycobrowser_v2 CDS 889926 890825 . - 0 Mb0819c PROBABLE OXIDOREDUCTASE [FIRST PART] Mb0819c, -, len: 299 aa. Equivalent to 5' end of Rv0794c, len: 499 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 263 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa); and similar to various oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa); NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase, similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa); Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Haloferax volcanii (475 aa); P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity in 467 aa overlap); P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa overlap); etc. Note that previously known as lpdB. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Mb0818c into 2 parts, Mb0818a and Mb0818b. Q7U192 No NC_002945.3 Mycobrowser_v2 CDS 933752 934780 . - 0 Mb0860c HYPOTHETICAL PROTEIN Mb0860c, -, len: 342 aa. Equivalent to Rv0837c,len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 342 aa overlap). Hypothetical unknown protein. TBparse score is 0.941. Q7U156 No conserved hypotheticals Rv0837c NC_002945.3 Mycobrowser_v2 CDS 891218 892312 . + 0 Mb0820 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1547 Mb0820, -, len: 364 aa. Equivalent to Rv0797, len 364 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 364 aa overlap). Putative transposase for IS1547; almost identical to (but 20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium tuberculosis (383 aa). Also similar to other transposases e.g. MAIS1110A _1|Q48909 transposase from M. avium (464 aa), FASTA scores: opt: 226, E(): 2.4e-08, (30.7% identity in 199 aa overlap). Also slight similarity to Rv2014|MTCY39.03c from Mycobacterium tuberculosis (222 aa), FASTA score: (24.8% identity in 141 aa overlap). Q7U191 No insertion seqs and phages Rv0797 NC_002945.3 Mycobrowser_v2 CDS 893096 894103 . - 0 Mb0822c conserved protein Mb0822c, -, len: 335 aa. Equivalent to Rv0799c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Conserved hypothetical protein, similar to Q50021|U2266C from Mycobacterium leprae (146 aa), FASTA scores: opt: 147,E(): 0.0016, (33.3% identity in 117 aa overlap); Q50020|U2266B from Mycobacterium leprae (27 aa), FASTA scores: opt: 94, E(): 1.3, (56.5% identity in 23 aa overlap). Also highly similar to others e.g. CAC01593.1|AL391041 conserved hypothetical protein from Streptomyces coelicolor (316 aa); AF088897|AF088897_9 hypothetical protein from Zymomonas mobilis (322 aa),FASTA scores: opt: 1132, E(): 0, (56.1% identity in 303 aa overlap); P76536|ECAE000330_8 hypothetical protein from Escherichia coli strain K-12 (308 aa), FASTA scores: E(): 2.2e-30, (37.4% identity in 297 aa overlap); etc. Also similar to some tyrA proteins. Q7U189 No conserved hypotheticals Rv0799c NC_002945.3 Mycobrowser_v2 CDS 894148 895449 . + 0 Mb0823 pepC PROBABLE AMINOPEPTIDASE PEPC Mb0823, pepC, len: 433 aa. Equivalent to Rv0800,len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 433 aa overlap). Probable pepC,aminopeptidase I (EC 3.4.11.-), highly similar (but shorter 17 aa) to Q50022|PEPX AMINOPEPTIDASE from Mycobacterium leprae (443 aa), FASTA scores: opt: 2237,E(): 0, (78.3% identity in 433 aa overlap). Also highly similar to others from Eukaryotes and bacteria, e.g. T36482 probable aminopeptidase from Streptomyces coelicolor (432 aa), P14904|AMPL_YEAST vacuolar aminopeptidase I precursor from Saccharomyces cerevisiae (514 aa), FASTA scores: opt: 425, E(): 4.8e-21, (31.0% identity in 445 aa overlap); etc. Also similar to hypothetical proteins e.g. P38821|YHR3_YEAST hypothetical 54.2 kd protein from Saccharomyces cerevisiae (490 aa),FASTA scores: opt: 429, E(): 2.5e-21, (34.8% identity in 443 aa overlap); etc. X2BG29,P59951 No intermediary metabolism and respiration Rv0800 NC_002945.3 Mycobrowser_v2 CDS 895461 895808 . + 0 Mb0824 conserved protein Mb0824, -, len: 115 aa. Equivalent to Rv0801, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins from Streptomyces sp. e.g. SCD840A.20|AB81865.1|AL161691 hypothetical protein from Streptomyces coelicolor (145 aa); AF072709|AF072709_8 from Streptomyces lividans (131 aa), FASTA scores: opt: 120,E(): 0.2, (26.3% identity in 118 aa overlap); etc. Q7U188 No conserved hypotheticals Rv0801 NC_002945.3 Mycobrowser_v2 CDS 895802 896458 . - 0 Mb0825c possible succinyltransferase in the gcn5-related n-acetyltransferase family Mb0825c, -, len: 218 aa. Equivalent to Rv0802c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Conserved hypothetical protein, showing partial similarity with many acetyltransferases and hypothetical proteins e.g. P96579|BSUB0003_68 PROBABLE ACETYLTRANSFERASE from Bacillus subtilis (183 aa), FASTA scores: E(): 0.0044,(26.4% identity in 110 aa overlap). Q7U187 No intermediary metabolism and respiration Rv0802c NC_002945.3 Mycobrowser_v2 CDS 896650 898914 . + 0 Mb0826 purL PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) Mb0826, purL, len: 754 aa. Equivalent to Rv0803,len: 754 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 754 aa overlap). purL,phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3) (see citations below), equivalent to NP_302451.1|NC_002677 phosphoribosylformylglycinamidine synthase II from Mycobacterium leprae (754 aa). Also highly similar to others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor (752 aa); P12042|PURL_BACSU from Bacillus subtilis (742 aa), FASTA score: (44.7% identity in 716 aa); etc. Start was chosen by similarity. BELONGS TO THE FGAMS FAMILY. X2BG81,P0A5T9 No intermediary metabolism and respiration Rv0803 NC_002945.3 Mycobrowser_v2 CDS 899661 900617 . + 0 Mb0828 class iii cyclic nucleotide phosphodiesterase (cnmp pde) Mb0828, -, len: 318 aa. Equivalent to Rv0805, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Conserved hypothetical protein, equivalent to Q50024 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa),FASTA scores: opt: 1713, E(): 0, (82.5% identity in 315 aa overlap). Also shows similarity with hypothetical proteins and icc proteins e.g. SC9B1.22c|T35867 hypothetical protein from Streptomyces coelicolor (305 aa); P36650|ICC_ECOLI icc protein from Escherichia coli (275 aa), FASTA scores: opt: 310, E(): 8.9e-14, (31.3% identity in 214 aa overlap); etc. Q7U185 No intermediary metabolism and respiration Rv0805 NC_002945.3 Mycobrowser_v2 CDS 900562 902160 . - 0 Mb0829c cpsY POSSIBLE UDP-GLUCOSE-4-EPIMERASE CPSY (GALACTOWALDENASE) (UDP-GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE-4-EPIMERASE) Mb0829c, cpsY, len: 532 aa. Equivalent to Rv0806c,len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 532 aa overlap). Possible cpsY,UDP-glucose-4-epimerase (EC 5.1.3.2), equivalent to Q50025|CPSY probable UDP-glucose-4-epimerase from Mycobacterium leprae (542 aa), FASTA scores: opt: 2964,E(): 0, (82.3% identity in 530 aa overlap). Also similar to AAC38286.1|AF019760|SACB CpsY homolog (involved in meningococcal capsule biosynthesis) from Neisseria meningitidis serogroup A (545 aa); Q51151 CAPSULE GENE COMPLEX UPD-GLUCOSE-4-EPIMERASE (GALE) from Neisseria meningitidis (373 aa), FASTA scores: opt: 496, E(): 9.5e-27, (29.3% identity in 358 aa overlap); C-terminus of CAB75373.1|AL139298 putative transferase from Streptomyces coelicolor (942 aa); and many hypothetical proteins from Streptomyces coelicolor. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY. X2BG73,Q7U184 No NC_002945.3 Mycobrowser_v2 CDS 902465 902854 . + 0 Mb0830 CONSERVED HYPOTHETICAL PROTEIN Mb0830, -, len: 129 aa. Equivalent to Rv0807, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, equivalent to O05761|MLCB5_31 HYPOTHETICAL 14.0 KD PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: E(): 0, (73.4% identity in 128 aa overlap). Also highly similar to BAA89438.1|AB003158|ORF3 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (132 aa); and C-terminus of SCD25.20|CAB56364.1|AL118514 hypothetical protein from Streptomyces coelicolor (202 aa). Q7U183 No conserved hypotheticals Rv0807 NC_002945.3 Mycobrowser_v2 CDS 902941 904524 . + 0 Mb0831 purF amidophosphoribosyltransferase purf (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpatase) Mb0831, purF, len: 527 aa. Equivalent to Rv0808,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 527 aa overlap). Probable purF,amidophosphoribosyltransferase (EC 2.4.2.14), equivalent to MLCB5_32|Q50028|PURF from Mycobacterium leprae (556 aa), FASTA scores: (91.3% identity in 518 aa overlap); and CAB96578.1|AJ278609 phosphoribosyl pyrophosphate amidotransferase from Mycobacterium smegmatis (511 aa). Also highly similar to others e.g. BAA89439.1|AB003158 amidophosphoribosyl transferase from Corynebacterium ammoniagenes (490 aa); P00497|PUR1_BACSU amidophosphoribosyltransferase precursor from Bacillus subtilis (476 aa), FASTA scores: opt: 1412, E(): 0, (46.2% identity in 470 aa overlap); etc. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. X2BG87,P65830 No intermediary metabolism and respiration Rv0808 NC_002945.3 Mycobrowser_v2 CDS 1506219 1506581 . - 0 Mb1377c CONSERVED MEMBRANE PROTEIN Mb1377c, -, len: 120 aa. Equivalent to Rv1342c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 120 aa overlap). Conserved membrane protein. Highly similar to G466926|P54133 hypothetical protein B1549_F2_59 from Mycobacterium leprae (119 aa),FASTA scores, opt: 544, E(): 1.9e-29, (68.3 % identity in 120 aa overlap). X2BHM0,P0A5E8 No cell wall and cell processes Rv1342c NC_002945.3 Mycobrowser_v2 CDS 904555 905649 . + 0 Mb0832 purM PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) Mb0832, purM, len: 364 aa. Equivalent to Rv0809,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Probable purM,5'-phosphoribosyl-5-aminoimidazole synthetase (EC 6.3.3.1), equivalent to NP_302446.1|NC_002677 5'-phosphoribosyl-5-aminoimidazole synthase from Mycobacterium leprae (364 aa). Also highly similar to many e.g. P12043|PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE from Bacillus subtilis (346 aa), FASTA scores: opt: 1023, E(): 0, (46.5% identity in 331 aa overlap); U68765|STU68765_2 from Salmonella typhimurium (345 aa), FASTA scores: opt: 1014, E():0, (47.6% identity in 330 aa overlap); etc. Q7U182 No intermediary metabolism and respiration Rv0809 NC_002945.3 Mycobrowser_v2 CDS 905735 905917 . - 0 Mb0833c CONSERVED HYPOTHETICAL PROTEIN Mb0833c, -, len: 60 aa. Equivalent to Rv0810c, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Conserved hypothetical protein, with its N-terminus highly similar to NP_302445.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (62 aa); and AL118514|SCD25_24 hypothetical protein from Streptomyces coelicolor (84 aa),FASTA scores: opt: 180, E(): 5.7e-07, (51.8% identity in 56 aa overlap). TBparse score is 0.876. Q7U181 No conserved hypotheticals Rv0810c NC_002945.3 Mycobrowser_v2 CDS 906064 907170 . - 0 Mb0834c conserved protein Mb0834c, -, len: 368 aa. Equivalent to Rv0811c,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 368 aa overlap). Conserved hypothetical protein, equivalent to U2266F|U15182|MLU15182_13 HYPOTHETICAL PROTEIN from Mycobacterium leprae (366 aa), FASTA scores: opt: 1870,E(): 0, (77.4% identity in 367 aa overlap). Also highly similar to BAA89441.1|AB003158|ORF4 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (359 aa); and CAB94085.1|AL358692 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (321 aa). Q7U180 No conserved hypotheticals Rv0811c NC_002945.3 Mycobrowser_v2 CDS 907253 908122 . + 0 Mb0835 PROBABLE AMINO ACID AMINOTRANSFERASE Mb0835, -, len: 289 aa. Equivalent to Rv0812, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 289 aa overlap). Probable amino acid aminotransferase (EC 2.6.1.-), similar to other amino acid aminotransferases, generelly CLASS-IV OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, and especially ILVE proteins and PABC proteins e.g. B76065.1|AL157953 putative aminotransferase from Streptomyces coelicolor (273 aa); NP_069766.1|NC_000917 branched-chain amino acid aminotransferase (ilvE) from Archaeoglobus fulgidus (290 aa); P54692|DAAA_BACLI D-ALANINE AMINOTRANSFERASE from Bacillus licheniformis (283 aa); P28305|PABC_ECOLI 4-AMINO-4-DEOXYCHORISMATE LYASE From Escherichia coli (269 aa), FASTA scores: opt: 165, E(): 0.00064, (26.8% identity in 198 aa overlap); etc. Note that previously known as pabC. Q7U179 No intermediary metabolism and respiration Rv0812 NC_002945.3 Mycobrowser_v2 CDS 908168 908848 . - 0 Mb0836c conserved protein Mb0836c, -, len: 226 aa. Equivalent to Rv0813c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Conserved hypothetical protein, highly similar to U15182|MLU15182_16 HYPOTHETICAL PROTEIN from Mycobacterium leprae (242 aa),FASTA scores: opt: 1191, E(): 0, (78.3% identity in 226 aa overlap); and NP_302442.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (228 aa). Also similar to AB94083.1|AL358692|SCD66.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (191 aa); and Rv2717c|MTCY05A6_37 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (164 aa), FASTA score: (30.4% identity in 171 aa overlap). X2BG93,Q7U178 No conserved hypotheticals Rv0813c NC_002945.3 Mycobrowser_v2 CDS 909011 909313 . - 0 Mb0837c sseC2 conserved protein ssec2 Mb0837c, sseC2, len: 100 aa. Equivalent to Rv0814c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). sseC2, conserved hypothetical protein, highly similar to AAA62972.1|U15182|MLU15182_17 hypothetical protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 545,E(): 0, (84.0% identity in 100 aa overlap); and NP_302441.1|NC_002677|Z95150|MTCY164_29 conserved hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 647, E(): 0, (100.0% identity in 100 aa overlap). Also highly similar to M29612|SERCYSA_5 rhodanese-like protein from Saccharopolyspora erythraea (101 aa), FASTA scores: opt: 345, E(): 1.2e-18, (57.1% identity in 98 aa overlap); and similar at the C-terminus to the C-terminus of CAB94069.1|AL358692 conserved hypothetical protein from Streptomyces coelicolor (95 aa). Identical second copy present as Rv3118|MTCY164.28|SSEC1 from Mycobacterium tuberculosis (100 aa) (100.0% identity in 100 aa overlap). Q7U177 No NC_002945.3 Mycobrowser_v2 CDS 909315 910148 . - 0 Mb0838c cysA2 PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) Mb0838c, cysA2, len: 277 aa. Equivalent to Rv0815c,len: 277 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 277 aa overlap). Probable cysA2,thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER PUTATIVE THIOSULFATE SULFURTRANSFERASE from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa); NP_293941.1|NC_001263 thiosulfate sulfurtransferase from Deinococcus radiodurans (286 aa); etc. Identical second copy present as Rv3117|MTCY164.27|MT3199|O05793|cysA3 (277 aa) (100.0% identity in 277 aa overlap). Contains PS00683 Rhodanese C-terminal signature at C-terminus. BELONGS TO THE RHODANESE FAMILY. X2BG48,P59989 No NC_002945.3 Mycobrowser_v2 CDS 910441 910863 . - 0 Mb0839c thiX PROBABLE THIOREDOXIN THIX Mb0839c, thiX, len: 140 aa. Equivalent to Rv0816c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable thiX,thioredoxin (EC 1.-.-.-), equivalent to ThiX|U15182|MLU15182_21 thioredoxin from Mycobacterium leprae (172 aa), FASTA scores: opt: 556, E(): 8.8e-31,(63.8% identity in 141 aa overlap); and similar to AAL08576.1|AF418548_2|AF418548 thioredoxin from Mycobacterium avium subsp. paratuberculosis (117 aa). Also similar to other bacterial thioredoxins e.g. CAB95303.1|AL359779 putative thioredoxin from Streptomyces coelicolor (126 aa); P33791|THIO_STRAU|TRX|TRXA THIOREDOXIN from Streptomyces aureofaciens (106 aa); etc. And similar to Rv3914|MT4033|MTV028.05|NP_218431.1|NC_000962|trxC THIOREDOXIN (TRX) (MPT46) from Mycobacterium tuberculosis (116 aa). Has hydrophobic stretch at N-terminus. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY. Q7U176 No NC_002945.3 Mycobrowser_v2 CDS 911802 912569 . + 0 Mb0841 TRANSCRIPTIONAL REGULATORY PROTEIN Mb0841, -, len: 255 aa. Equivalent to Rv0818, len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 255 aa overlap). Probable transcriptional regulatory protein, highly similar to Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 945, E(): 0, (61.5 identity in 239 aa overlap); and similar to others from other organisms. Also similar to Rv2884|MTCY274.15|Z74024 from Mycobacterium tuberculosis (252 aa), FASTA scores: opt: 662, E(): 0, (47.8% identity in 226 aa overlap). Q7U174 No regulatory proteins Rv0818 NC_002945.3 Mycobrowser_v2 CDS 912566 913513 . + 0 Mb0842 mshd gcn5-related n-acetyltransferase, mshd Mb0842, -, len: 315 aa. Equivalent to Rv0819, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 315 aa overlap). Conserved hypothetical protein, equivalent to U2266N|U15182|MLU15182_24 HYPOTHETICAL PROTEIN from Mycobacterium leprae (312 aa), FASTA scores: opt: 1540,E(): 0, (75.2% identity in 314 aa overlap). Also highly similar to CAB88484.1|AL353816 putative acetyltransferase from Streptomyces coelicolor (309 aa). X2BFZ8,Q7U173 No intermediary metabolism and respiration Rv0819 NC_002945.3 Mycobrowser_v2 CDS 913556 914332 . + 0 Mb0843 phoT PROBABLE PHOSPHATE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PHOT Mb0843, phoT, len: 258 aa. Equivalent to Rv0820,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 258 aa overlap). Probable phoT,phosphate-transport ATP-binding protein ABC transporter (see citation below), equivalent to PhoT|MLU15182_28|U15182 phosphate transport system ABC transporter from Mycobacterium leprae (258 aa), FASTA scores: opt: 1556, E(): 0, (91.5% identity in 258 aa overlap). Also highly similar to others e.g. CAB88472.1|AL353816 phosphate ABC transport system ATP-binding protein from Streptomyces coelicolor (258 aa); etc. Note that also highly similar to many PstB proteins e.g. AAC15686.1|AF045938|PstB putative ABC transporter nucleotide binding subunit from Mycobacterium smegmatis (258 aa). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). X2BG54,Q7U172 No cell wall and cell processes Rv0820 NC_002945.3 Mycobrowser_v2 CDS 914388 915029 . - 0 Mb0844c phoY2 PROBABLE PHOSPHATE-TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PHOY2 Mb0844c, phoY2, len: 213 aa. Equivalent to Rv0821c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Probable phoY2,phosphate-transport system regulatory protein, highly similar to PhoY|MLU15182_29|U15182 phosphate transport system regulator from Mycobacterium leprae (222 aa), FASTA scores: opt: 1268, E(): 0, (93.0% identity in 213 aa overlap). Also similar to others e.g. NP_384620.1|NC_003047 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Sinorhizobium meliloti (237 aa); etc. Also highly similar to MTCI418A.03c|Z96070|PhoY1 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 937, E(): 0, (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY. TBparse score is 0.910. X2BG89,P65721 No NC_002945.3 Mycobrowser_v2 CDS 915087 917141 . - 0 Mb0845c conserved protein Mb0845c, -, len: 684 aa. Equivalent to Rv0822c,len: 684 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 684 aa overlap). Conserved hypothetical protein, highly similar in the region between aa 370 - 580 to U2266O|U15182|MLU15182_30 HYPOTHETICAL PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 819,E(): 0, (60.6% identity in 221 aa overlap). More extended similarity to Rv3267|Z92771|MTCY71_7 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 434, E(): 2.2e-17, (26.6% identity in 541 aa overlap), and Rv3484. Also similar to various proteins, preferiously putative membrane proteins and membrane-bound regulatory proteins e.g. CAC44512.1|AL596138 putative membrane protein from Streptomyces coelicolor (524 aa); U56901|BSU56901_1 regulatory protein from Bacillus subtilis (391 aa), FASTA scores: opt: 225, E(): 1.3e-05, (24.7% identity in 340 aa overlap). Contains hydrophobic stretch (aa ~ 160-195) and PS00041 Bacterial regulatory proteins, araC family signature. Q7U171 No conserved hypotheticals Rv0822c NC_002945.3 Mycobrowser_v2 CDS 922405 922695 . + 0 Mb0852 possible transposase (fragment) Mb0852, -, len: 96 aa. Equivalent to Rv0829, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 96 aa overlap). Possible transposase for IS1605' (fragment), similar to C-terminal end of many mycobacterial transposases and hypothetical proteins e.g. Z74024|MTCY274_16 from Mycobacterium tuberculosis (460 aa), FASTA scores: opt: 668, E(): 6.2e-32, (98.9% identity in 93 aa overlap); MTV002_57|O33333 TRANSPOSASE from Mycobacterium tuberculosis ; L07627|SERRY1_1 insertion element IS1136 from Saccharopolyspora erythraea (90 aa),FASTA score: (34.9% identity in 83 aa overlap). Q7U164 No insertion seqs and phages Rv0829 NC_002945.3 Mycobrowser_v2 CDS 1751151 1751555 . + 0 Mb1587 vapc11 possible toxin vapc11 Mb1587, -, len: 134 aa. Equivalent to Rv1561, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 134 aa overlap). Conserved hypothetical protein, similar to others from Mycobacterium tuberculosis e.g. Q10847|Rv2010|MTCY39.07c (132 aa), FASTA scores: (37.0% identity in 127 aa overlap); and O06566|Rv1114|MTCY22G8.03 (124 aa). X2BIQ3,P64880 No virulence, detoxification, adaptation Rv1561 NC_002945.3 Mycobrowser_v2 CDS 917307 918476 . - 0 Mb0846c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0846c, -, len: 389 aa. Equivalent to Rv0823c,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 389 aa overlap). Possible transcriptional regulator (resembles nitrogen regulation protein), equivalent (but longer 24 aa in N-terminus) to MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium leprae (384 aa), FASTA scores: opt: 2070, E(): 0, (82.3% identity in 384 aa overlap) (see citation below). Also highly similar to CAB63312.1|AL133471|SCC82.03c hypothetical protein from Streptomyces coelicolor (406 aa); and to many transcriptional regulators members of UPF0034 FAMILY (NIFR3/SMM1) e.g. D26185|BAC180K_143 protein similar to transcriptional regulator (nitrogen regulation protein) from Bacillus subtilis (333 aa), FASTA scores: opt: 609, E(): 1.4e-32, (38.3% identity in 326 aa overlap); NP_349795.1|NC_003030 NifR3 family enzyme from Clostridium acetobutylicum (321 aa); etc. Contains PS01136 Uncharacterized protein family UPF0034 signature. Q7U170 No regulatory proteins Rv0823c NC_002945.3 Mycobrowser_v2 CDS 918564 919580 . - 0 Mb0847c desA1 PROBABLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA1 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) (PROTEIN DES) Mb0847c, desA1, len: 338 aa. Equivalent to Rv0824c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 338 aa overlap). Probable desA1 (alternate gene name: des), acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.19.2) (see first citation below), equivalent to U15182|MLU15182_32 acyl-[ACP] desaturase from Mycobacterium leprae (338 aa),FASTA scores: opt: 1880, E(): 0, (79.9% identity in 338 aa overlap); and highly similar in part to fragment CAB96061.1|AJ250019 Steroyl-ACP-desaturase from Mycobacterium avium subsp. paratuberculosis (93 aa). Also similar to other fatty acid desaturases e.g. T35035 probable acyl-[acyl-carrier protein] desaturase from Streptomyces coelicolor (328 aa); Q40731|STAD_ORYSA ACYL-[ACYL-CARRIER PROTEIN] DESATURASE PRECURSOR from Oryza sativa (Rice) (390 aa); etc. Also highly similar to desA2|Rv1094 from Mycobacterium tuberculosis (275 aa). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. BELONGS TO THE FATTY ACID DESATURASE FAMILY. COFACTOR: FERREDOXIN, FERREDOXIN NADPH REDUCTASE,AND NADPH. Q7U169 No NC_002945.3 Mycobrowser_v2 CDS 919742 920383 . - 0 Mb0848c conserved protein Mb0848c, -, len: 213 aa. Equivalent to Rv0825c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, highly similar, but in part (between aa ~43-96) to fadD27|Rv0275c|MTV035.03 PUTATIVE FATTY-ACID-COA LIGASE from Mycobacterium tuberculosis (241 aa), FASTA scores: E(): 7.3e-09, (32.6% identity in 190 aa overlap). Also shows similarity with other proteins from Mycobacterium tuberculosis e.g. Rv0078|AL0214|MTV030_22 (201 aa), FASTA scores: opt:118, E(): 0.32, (34.5% identity in 113 aa overlap); etc. Q7U168 No conserved hypotheticals Rv0825c NC_002945.3 Mycobrowser_v2 CDS 920464 921519 . + 0 Mb0849 CONSERVED HYPOTHETICAL PROTEIN Mb0849, -, len: 351 aa. Equivalent to Rv0826, len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 351 aa overlap). Conserved hypothetical protein, similar to CAB94053.1|AL358672|SC7A12.06 hypothetical protein from Streptomyces coelicolor (300 aa); and NP_421372.1|NC_002696 hypothetical protein from Caulobacter crescentus (299 aa). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv1645c|Z85982|MTCY06H11.09 (351 aa), FASTA scores: opt: 1199, E(): 0, (57.5% identity in 299 aa overlap); Rv2237; Rv0276; etc. Q7U167 No conserved hypotheticals Rv0826 NC_002945.3 Mycobrowser_v2 CDS 925781 926194 . + 0 Mb0855 PE_PGRS12 pe-pgrs family protein pe_pgrs12 Mb0855, PE_PGRS12, len: 137 aa. Equivalent to Rv0832, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 137 aa overlap). Member of the Mycobacterium tuberculosis PE family, possibly PGRS subfamily of gly-rich proteins, highly similar to many others e.g. MTCY1A11.25c|Z78020 (498 aa), FASTA scores: opt: 529, E(): 5.2e-22, (61.8% identity in 136 aa overlap); etc. Appears to have incurred frameshift as next ORF should be continuation; sequence has been checked but no error found. Q7U161 No NC_002945.3 Mycobrowser_v2 CDS 921571 921963 . - 0 Mb0850c kmtr metal sensor transcriptional regulator kmtr (arsr-smtb family) Mb0850c, -, len: 130 aa. Equivalent to Rv0827c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Probable transcriptional regulator, similar to many e.g. CAC42856.1|AL592292 putative regulatory protein from Streptomyces coelicolor (115 aa); NP_301626.1|NC_002677 putative ArsR-family transcriptional regulator from Mycobacterium leprae (140 aa); BSUB0011_75|O31844|Z99114 YOZA PROTEIN from Bacillus subtilis (107 aa), FASTA scores: opt: 208, E(): 3.2e-08, (35.5% identity in 93 aa overlap); etc. Also similar to MTCY27.22c|Z95208 from Mycobacterium tuberculosis (135 aa), FASTA scores: opt: 201, E(): 1.2e-07, (35.7% identity in 98 aa overlap). Contains probable helix-turn helix motif from aa 42-63 (Score 1300, +3.61 SD). Q7U166 No regulatory proteins Rv0827c NC_002945.3 Mycobrowser_v2 CDS 1108623 1108955 . - 0 Mb1018c conserved serine rich protein Mb1018c, -, len: 110 aa. Equivalent to Rv0991c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Conserved hypothetical ser-rich protein (especially in C-terminus), highly similar to N-terminus of NP_301255.1|NC_002677 conserved hypothetical protein (Ser-rich C-terminus) from Mycobacterium leprae (99 aa). Also highly similar to SCE22.04|AB90971.1|AL355832 hypothetical protein from Streptomyces coelicolor (110 aa); and similar to others. Q7U0W5 No conserved hypotheticals Rv0991c NC_002945.3 Mycobrowser_v2 CDS 922021 922443 . - 0 Mb0851c POSSIBLE DEAMINASE Mb0851c, -, len: 140 aa. Equivalent to Rv0828c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Possible deaminase (EC 3.5.-.-), with its N-terminus highly similar to middle part of NP_302602.1|NC_002677 possible cytidine/deoxycytidylate deaminase from Mycobacterium leprae (171 aa). Also similar to other deaminases e.g. CAC18715.2|AL451182 putative deaminase from Streptomyces coelicolor (167 aa); NP_251189.1|NC_002516 probable deaminase from Pseudomonas aeruginosa (151 aa); NP_108387.1|NC_002678 nitrogen fixation protein gene from Mesorhizobium loti (149 aa); etc. Also similar to many conserved hypothetical proteins e.g. NP_389200.1|NC_000964 hypothetical protein from Bacillus subtilis (156 aa),FASTA scores: E(): 1.3e-07, (38.9% identity in 95 aa overlap); etc. And similar to Rv3752c possible deaminase from Mycobacterium tuberculosis. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. Q7U165 No intermediary metabolism and respiration Rv0828c NC_002945.3 Mycobrowser_v2 CDS 922800 923705 . + 0 Mb0853 possible s-adenosylmethionine-dependent methyltransferase Mb0853, -, len: 301 aa. Equivalent to Rv0830, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, member of Mycobacterium tuberculosis protein family consisting of the proteins Rv0726c,Rv0731c, Rv3399, Rv1729c|Z81360|MTCY4C12_14c (312 aa),FASTA scores: opt: 1014, E(): 0, (54.1% identity in 292 aa overlap); etc. X2BG66,Q7U163 No lipid metabolism Rv0830 NC_002945.3 Mycobrowser_v2 CDS 923724 924539 . - 0 Mb0854c conserved protein Mb0854c, -, len: 271 aa. Equivalent to Rv0831c,len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 271 aa overlap). Conserved hypothetical protein, similar to Rv0347|MTY13E10_7|Z95324 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (328 aa), FASTA scores: opt: 426, E(): 2.6e-21, (33.6% identity in 262 aa overlap). Q7U162 No conserved hypotheticals Rv0831c NC_002945.3 Mycobrowser_v2 tRNA 924633 924705 . - 0 lysT lysT tRNA-Lys lysT, len: 73 nt. Equivalent to lysT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Lys, anticodon ttt. No NC_002945.3 Mycobrowser_v2 tRNA 924829 924902 . + 0 gluT gluT tRNA-Glu gluT, len: 74 nt. Equivalent to gluT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Glu, anticodon ttc. No NC_002945.3 Mycobrowser_v2 CDS 926191 928512 . + 0 Mb0856 PE_PGRS13 pe-pgrs family protein pe_pgrs13 Mb0856, PE_PGRS13, len: 773 aa. Equivalent to Rv0833, len: 749 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, but lacking N-terminal domain (present in preceding ORF),possibly due to frameshift. Similar in part to many others e.g. MTCY28_25|Z95890 (914 aa), FASTA scores: opt: 2726,E(): 0, (60.1% identity in 776 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 84 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (773 aa versus 749 aa). Q7U160 No NC_002945.3 Mycobrowser_v2 CDS 928739 931234 . - 0 Mb0857c PE_PGRS14 pe-pgrs family protein pe_pgrs14 Mb0857c, PE_PGRS14, len: 831 aa. Equivalent to Rv0834c, len: 882 aa, from Mycobacterium tuberculosis strain H37Rv. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many others e.g. MTCY493_4|Z95844 (1329 aa),FASTA scores: opt: 2577, E(): 0, (52.0% identity in 950 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 882 aa). Q7U159 No NC_002945.3 Mycobrowser_v2 CDS 931702 932346 . + 0 Mb0858 lpqQ POSSIBLE LIPOPROTEIN LPQQ Mb0858, lpqQ, len: 214 aa. Equivalent to Rv0835,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 214 aa overlap). Possible lpqQ,lipoprotein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U158 No cell wall and cell processes Rv0835 NC_002945.3 Mycobrowser_v2 CDS 1771950 1772465 . - 0 Mb1611c Possible phage phiRv1 protein Mb1611c, -, len: 171 aa. Equivalent to Rv1585c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Possible phage phiRv1 protein (see citation below). Q7VEX1 No insertion seqs and phages Rv1585c NC_002945.3 Mycobrowser_v2 CDS 935469 936245 . + 0 Mb0861 lpqR PROBABLE CONSERVED LIPOPROTEIN LPQR Mb0861, lpqR, len: 258 aa. Equivalent to Rv0838,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 258 aa overlap). Probable lpqR,conserved lipoprotein. Similar (except in N-terminus) to hypothetical proteins and D-alanyl-D-alanine dipeptidases e.g. NP_416005.1|NC_000913 hypothetical protein from Escherichia coli strain K12 (193 aa); NP_421076.1|NC_002696 D-alanyl-D-alanine dipeptidase from Caulobacter crescentus (212 aa); Q06241|VANX_ENTFC D-ALANYL-D-ALANINE DIPEPTIDASE from Enterococcus faecium (202 aa), FASTA scores: opt: 198, E(): 1.9e-05, (28.1% identity in 199 aa overlap); etc. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 6bp insertion (*-cggccc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). Q7U155 No cell wall and cell processes Rv0838 NC_002945.3 Mycobrowser_v2 CDS 2003144 2004937 . - 0 Mb1808c possible integral membrane protein Mb1808c, -, len: 597 aa. Equivalent to Rv1779c,len: 597 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 597 aa overlap). Possible integral membrane protein. Q7TZK0 No cell wall and cell processes Rv1779c NC_002945.3 Mycobrowser_v2 CDS 1009409 1010527 . + 0 Mb0930 conserved protein Mb0930, -, len: 372 aa. Equivalent to Rv0906, len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 372 aa overlap). Conserved hypothetical protein, highly similar to others e.g. SC6A5.25|AL049485|T35416 hypothetical protein from Streptomyces coelicolor (370 aa), FASTA scores: opt: 1125,E(): 0, (51.3% identity in 335 aa overlap); NP_242955.1|NC_002570|BH2089 conserved protein from Bacillus halodurans (370 aa); etc. Also shows some similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer membrane protein roma (fragment) from Klebsiella pneumoniae (132 aa), FASTA scores: opt: 319, E(): 8.5e-14,(46.2% identity in 104 aa overlap); NP_105215.1|NC_002678 hypothetical protein which contains similarity to outer membrane protein romA from Enterobacter cloacae (350 aa); etc. X2BGG4,P64760 No conserved hypotheticals Rv0906 NC_002945.3 Mycobrowser_v2 CDS 936332 937144 . + 0 Mb0862 CONSERVED HYPOTHETICAL PROTEIN Mb0862, -, len: 270 aa. Equivalent to Rv0839, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Conserved hypothetical protein, similar to various hypothetical proteins or methyltransferases from yeast and bacteria e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hypothetical protein from Streptomyces coelicolor (273 aa), FASTA scores: opt: 1102, E(): 0, (58.6% identity in 263 aa overlap); T38024|Z98598|SPAC1B3.06c hypothetical protein from Schizosaccharomyces pombe (278 aa), FASTA scores: opt: 562, E(): 1.9e-3, (36.4% identity in 269 aa overlap); JC6531 avermectin B 5-O-methyltransferase (EC 2.1.1.-) from Streptomyces avermitilis (283 aa); etc. Also similar to other Mycobacterium tuberculosis hypothetical proteins that may be methyltransferases e.g. Rv1523, Rv2952,Rv1405c, etc. Q7U154 No conserved hypotheticals Rv0839 NC_002945.3 Mycobrowser_v2 CDS 937212 938072 . - 0 Mb0863c pip PROBABLE PROLINE IMINOPEPTIDASE PIP (PROLYL AMINOPEPTIDASE) (PAP) Mb0863c, pip, len: 286 aa. Equivalent to Rv0840c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible pip, proline iminopeptidase (EC 3.4.11.5), similar to many e.g. P46541|PIP_BACCO PROLINE IMINOPEPTIDASE from BACILLUS COAGULANS (288 aa), FASTA scores: opt: 657, E(): 0, (37.6% identity in 282 aa overlap); NP_386922.1|NC_003047 PUTATIVE PROLINE IMINOPEPTIDASE PROTEIN from Sinorhizobium meliloti (296 aa); etc. BELONGS TO PEPTIDASE FAMILY S33. Q7U153 No NC_002945.3 Mycobrowser_v2 CDS 938348 938590 . + 0 Mb0864 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0864, -, len: 80 aa. Equivalent to Rv0841, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 80 aa overlap). Conserved transmembrane protein, highly similar to C-terminus of next ORF Rv0842|O53854 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis (442 aa), FASTA scores: opt: 246, E(): 3.3e-10, (59.7% identity in 72 aa overlap). Replace previous Rv0841c. Q7U152 No cell wall and cell processes Rv0841 NC_002945.3 Mycobrowser_v2 CDS 938867 940159 . + 0 Mb0865 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0865, -, len: 430 aa. Equivalent to Rv0842, len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 430 aa overlap). Probable conserved integral membrane protein, showing similarity with other integral membrane proteins e.g. P28246|BCR_ECOLI BICYCLOMYCIN RESISTANCE PROTEIN from EScherichia coli (396 aa), FASTA scores: opt: 216, E(): 5.4e-07, (23.7% identity in 376 aa overlap); etc. Q7U151 No cell wall and cell processes Rv0842 NC_002945.3 Mycobrowser_v2 CDS 940143 941147 . + 0 Mb0866 PROBABLE DEHYDROGENASE Mb0866, -, len: 334 aa. Equivalent to Rv0843, len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 334 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to various dehydrogenases e.g. Q46142|Q46142 TPP-DEPENDENT ACETOIN DEHYDROGENASE (326 aa), FASTA scores: opt: 500, E(): 2.4e-26, (32.3% identity in 300 aa overlap); P51267|ODPA_PORPU PYRUVATE DEHYDROGENASE E1 COMPONENT from Porphyra purpurea (344 aa), FASTA scores: opt: 451, E(): 4.7e-23, (29.6% identity in 311 aa overlap); etc. Also similar to Rv2497c|pdhA pyruvate dehydrogenase E1 component from Mycobacterium tuberculosis (367 aa). Q7U150 No intermediary metabolism and respiration Rv0843 NC_002945.3 Mycobrowser_v2 CDS 941211 941861 . - 0 Mb0867c narL POSSIBLE NITRATE/NITRITE RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN NARL Mb0867c, narL, len: 216 aa. Equivalent to Rv0844c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 216 aa overlap). Possible narL,nitrate/nitrite response regulator protein, similar to many e.g. CAB44989.1|AJ131854 NarL protein from Pseudomonas stutzeri (218 aa); CAA75536.1|Y15252 nitrate/nitrite regulatory protein from Pseudomonas aeruginosa (216 aa); PCC6803|D64005|SYCSLRG_24 NarL protein from Synechocystis sp. (209 aa), FASTA scores: opt: 438, E(): 1.5e-23, (34.6% identity in 208 aa overlap); etc. Also similar to unidentified regulator e.g. CAB76009.1|AL157916 putative two-component system response regulator from Streptomyces coelicolor (224 aa); etc. Contains probable helix-turn helix motif from aa 170-191 (Score 1124, +3.02 SD). Q7U149 No NC_002945.3 Mycobrowser_v2 CDS 941945 943222 . + 0 Mb0868 POSSIBLE TWO COMPONENT SENSOR KINASE Mb0868, -, len: 425 aa. Equivalent to Rv0845, len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Possible two-component sensor kinase (EC 2.7.-.-), with its C-terminus similar to C-terminal part of others e.g. NP_294951.1|NC_001263 two-component sensor histidine kinase from Deinococcus radiodurans (469 aa); CAC32293.1|AL583943 putative two component system histidine kinase from Streptomyces coelicolor (404 aa); NP_464546.1|NC_003210 protein similar to two-component sensor histidine kinase from Listeria monocytogenes (352 aa); BSUB0017_193|Z9912 two-component sensor kinase from Bacillus subtilis (360 aa), FASTA scores: opt: 275, E(): 1.6e-11, (30.3% identity in 234 aa overlap); etc. Q7U148 No regulatory proteins Rv0845 NC_002945.3 Mycobrowser_v2 CDS 943435 944949 . - 0 Mb0869c PROBABLE OXIDASE Mb0869c, -, len: 504 aa. Equivalent to Rv0846c,len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 504 aa overlap). Probable oxidase (EC 1.-.-.-), showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins A (precursors) e.g. P24792|ASO_CUCMA L-ASCORBATE OXIDASE PRECURSOR (ASCORBASE) (EC 1.10.3.3) from Cucurbita maxima (Pumpkin) (Winter squash) (579 aa), FASTA scores: opt: 423, E(): 5.8e-18, (28.4% identity in 493 aa overlap); AF010496|AF010496_32 potential multicopper oxidase from Rhodobacter capsulatus (491 aa), FASTA scores: opt: 490,E(): 2.7e-22, (28.8% identity in 510 aa overlap); 47452|PCOA_ECOLI COPPER RESISTANCE PROTEIN A PRECURSOR (BELONGS TO THE FAMILY OF MULTICOPPER OXIDASES) from Escherichia coli strain K12 (605 aa); etc. Contains PS00080 Multicopper oxidases signature 2 at C-terminus. SEEMS TO BELONG TO THE FAMILY OF MULTICOPPER OXIDASES. Q7U147 No intermediary metabolism and respiration Rv0846c NC_002945.3 Mycobrowser_v2 CDS 945693 946811 . + 0 Mb0871 cysK2 POSSIBLE CYSTEINE SYNTHASE A CYSK2 (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE) Mb0871, cysK2, len: 372 aa. Equivalent to Rv0848,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 372 aa overlap). Possible cysK2,cysteine synthase A (EC 4.2.99.8), but could be also a cysteine synthase B (EC 4.2.99.8) cysM2-product, similar to many e.g. NP_109408.1|NC_002682 cysteine synthase from Mesorhizobium loti (357 aa); Q44004|CYSM_ALCEU CYSTEINE SYNTHASE from Alcaligenes eutrophus strain CH34 (Ralstonia eutropha) (339 aa), FASTA scores: opt: 511, E(): 1.7e-25,(35.0% identity in 314 aa overlap); etc. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE. Note that previously known as cysM3. Q7U145 No NC_002945.3 Mycobrowser_v2 CDS 946811 948070 . + 0 Mb0872 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Mb0872, -, len: 419 aa. Equivalent to Rv0849, len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 419 aa overlap). Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS) involved in transport of drug, showing similarity with others e.g. T35055 probable transport system permease protein from Streptomyces coelicolor (436 aa); NP_295031.1|NC_001263 major facilitator family protein from Deinococcus radiodurans (458 aa); NP_455659.1|NC_003198 putative membrane transporter from Salmonella enterica subsp. enterica serovar Typhi (402 aa); etc. Q7U144 No cell wall and cell processes Rv0849 NC_002945.3 Mycobrowser_v2 CDS 948067 948399 . + 0 Mb0873 PUTATIVE TRANSPOSASE (FRAGMENT) Mb0873, -, len: 110 aa. Equivalent to Rv0850, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Putative transposase (fragment), similar in part to others e.g. Q45144|Q4514 TRANSPOSABLE ELEMENT IS31831 (436 aa), FASTA scores: opt: 175, E(): 4.3e-05, (38.6% identity in 57 aa overlap); etc. Q7U143 No insertion seqs and phages Rv0850 NC_002945.3 Mycobrowser_v2 CDS 948396 949223 . - 0 Mb0874c probable short-chain type dehydrogenase/reductase Mb0874c, -, len: 275 aa. Equivalent to Rv0851c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 275 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to many e.g. Q01198|LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC 1.1.1.-)(SDR FAMILY) from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (305 aa); D11473|PSELIG_1 C alpha-dehydrogenase from P. paucimobilis (305 aa), FASTA scores: opt: 468, E(): 4.9e-23, (30.8% identity in 279 aa overlap); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U142 No intermediary metabolism and respiration Rv0851c NC_002945.3 Mycobrowser_v2 CDS 949314 950150 . + 0 Mb0875 fadD16 POSSIBLE FATTY-ACID-COA LIGASE FADD16 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb0875, fadD16, len: 278 aa. Equivalent to Rv0852,len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Possible fadD16,fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to various CoA ligases e.g. P18163|LCFB_RAT LONG-CHAIN-FATTY-ACID--COA LIGASE from Rattus norvegicus (Rat) (699 aa); D49366|LEP4CCOALA_1 4-coumarate:CoA ligase from Lithospermum erythrorhizon (636 aa), FASTA scores: opt: 134, E(): 0.15, (26.8% identity in 213 aa overlap); orgp|L09229|HUMFACAL_1 long-chain acyl-coenzyme A from homo sapiens (human) (699 aa), FASTA score: (50.0% identity in 40 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7U141 No NC_002945.3 Mycobrowser_v2 CDS 1016702 1017151 . + 0 Mb0936 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0936, -, len: 149 aa. Equivalent to Rv0912, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 149 aa overlap). Probable conserved transmembrane protein, equivalent to Q50121|NP_302397.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 677, E(): 6.9e-38, (69.5% identity in 141 aa overlap). Q7U117 No cell wall and cell processes Rv0912 NC_002945.3 Mycobrowser_v2 CDS 950191 951873 . - 0 Mb0876c pdc PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC Mb0876c, pdc, len: 560 aa. Equivalent to Rv0853c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable pdc,pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-),equivalent to NP_302424.1|NC_002677 pyruvate (or indolepyruvate) decarboxylase from Mycobacterium leprae (569 aa). Also highly similar to others e.g. AAB06571.1|L80006 indolepyruvate decarboxylase from Pantoea agglomerans (550 aa); Q12629|DCPY_KLULA PYRUVATE DECARBOXYLASE (EC 4.1.1.1) from Kluyveromyces marxianus var. lactis (563 aa); P71323 INDOLEPYRUVATE DECARBOXYLASE (EC 4.1.1.74) from Enterobacter herbicola (550 aa), FASTA scores: opt: 1642, E(): 0, (48.1% identity in 547 aa overlap); P23234|DCIP_ENTCL INDOLE-3-PYRUVATE DECARBOXYLASE (INDOLEPYRUVATE DECARBOXYLASE) from Enterobacter cloacae (552 aa), FASTA scores: opt: 1596,E(): 0, (46.8% identity in 551 aa overlap); etc. Contains PS00187 Thiamine pyrophosphate enzymes signature and PS00017 ATP/GTP-binding site motif A (P-loop). COFACTOR: THIAMINE PYROPHOSPHATE. X2BGC9,Q7U140 No NC_002945.3 Mycobrowser_v2 CDS 951938 952381 . + 0 Mb0877 conserved protein Mb0877, -, len: 147 aa. Equivalent to Rv0854, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein, similar to several hypothetical protein from Mycobacterium leprae e.g. NP_301674.1|NC_002677 (144 aa); NP_302683.1|NC_002677|Z95398|MLCL622.27c (156 aa), FASTA scores: opt: 193, E(): 1.6e-06, (24.6% identity in 134 aa overlap); NP_301218.1|NC_002677 (146 aa); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 171, E(): 5.8e-05, (21.5% identity in 135 aa overlap). Also similar to SC6G10.02c|T35511|AL049497|SC6G10_2 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 344, E(): 6.1e- 17, (37.6% identity in 141 aa overlap). And similar to many proteins from Mycobacterium tuberculosis e.g. downstreams ORFs Rv0856 and Rv0857,etc. Q7U139 No conserved hypotheticals Rv0854 NC_002945.3 Mycobrowser_v2 CDS 952387 953466 . + 0 Mb0878 far PROBABLE FATTY-ACID-COA RACEMASE FAR Mb0878, far, len: 359 aa. Equivalent to Rv0855,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable far, fatty acid-CoA racemase (EC 5.1.-.-), highly similar to CAB08122.1|Z94723 unknown protein from Mycobacterium leprae (253 aa) (C-terminus shorter). Also similar to many eukaryotic and bacteria racemases e.g. T35425 probable fatty acid CoA racemase from Streptomyces coelicolor (387 aa); P70473|AMAC_RAT ALPHA-METHYLACYL-COA RACEMASE (2-METHYLACYL-COA RACEMASE) (2-ARYLPROPIONYL-COA EPIMERASE) (EC 5.1.99.4) from Rattus norvegicus (Rat) (382 aa); NP_103687.1|NC_002678 probable fatty acid Co-A racemase from Mesorhizobium loti (389 aa); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv1143|MTCI65.10|MCR from Mycobacterium tuberculosis (360 aa), FASTA scores: opt: 1373, E(): 0, (56.8% identity in 359 aa overlap), Rv1866|MTCY359.07 (C-terminal half) (778 aa), Rv3272 (360 aa). Q7U138 No lipid metabolism Rv0855 NC_002945.3 Mycobrowser_v2 CDS 953579 953983 . + 0 Mb0879 CONSERVED HYPOTHETICAL PROTEIN Mb0879, -, len: 134 aa. Equivalent to Rv0856, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Conserved hypothetical protein, showing weak similarity with NP_301674.1| (NC_002677) conserved hypothetical protein from Mycobacterium leprae (144 aa); and SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. neighbouring ORF downstream Rv0857 CONSERVED HYPOTHETICAL PROTEIN (126 aa),FASTA scores: E(): 7.4e-27, (62.0% identity in 100 aa overlap); neighbouring ORF Rv0854|MTV043_47 CONSERVED HYPOTHETICAL PROTEIN (147 aa), FASTA scores: E(): 1.6e-15,(36.6% identity in 123 aa overlap),MTCI28.04|Z97050|MTCI28_4 (184 aa), FASTA scores: opt: 127, E(): 0.036, (26.0% identity in 127 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 123, E(): 0.06, (26.4% identity in 125 aa overlap). Q7U137 No conserved hypotheticals Rv0856 NC_002945.3 Mycobrowser_v2 CDS 2005157 2005720 . + 0 Mb1809 conserved protein Mb1809, -, len: 187 aa. Equivalent to Rv1780, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Conserved hypothetical protein, equivalent to Q49881|ML1380|U00021_2 cosmid L247 from Mycobacterium leprae (187 aa), FASTA scores: opt: 1000, E(): 0, (82.4% identity in 187 aa overlap). Q7TZJ9 No conserved hypotheticals Rv1780 NC_002945.3 Mycobrowser_v2 CDS 954011 954484 . + 0 Mb0880 CONSERVED HYPOTHETICAL PROTEIN Mb0880, -, len: 157 aa. Equivalent to Rv0857, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 157 aa overlap). Conserved hypothetical protein, showing weak similarity with SC6G10.02|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF Rv0856 (134 aa), FASTA scores: E(): 9.6e-28, (61.6% identity in 99 aa overlap); upstream ORF Rv0854 (147 aa), FASTA scores: E(): 2.8e-18, (42.7% identity in 117 aa overlap); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 122, E(): 0.031, (29.4% identity in 85 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 114, E(): 0.1, (30.9% identity in 55 aa overlap). Q7U136 No conserved hypotheticals Rv0857 NC_002945.3 Mycobrowser_v2 CDS 954481 955674 . - 0 Mb0881c dapc probable n-succinyldiaminopimelate aminotransferase dapc (dap-at) Mb0881c, -, len: 397 aa. Equivalent to Rv0858c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Probable aminotransferase (EC 2.6.1.-), highly similar to others from Eukaryota and bacteria, especially aspartate aminotransferases (transaminases) (EC 2.6.1.1), e.g. NP_177890.1|NC_003070 putative aminotransferase from Arabidopsis thaliana (440 aa); NP_419555.1|NC_002696 aminotransferase class I from Caulobacter crescentus (385 aa); NP_415133.1|NC_000913|AE0001|ECAE000165_8 putative aminotransferase from Escherichia coli strain K12 (386 aa), FASTA scores: opt: 830, E(): 0, (38.0% identity in 389 aa overlap); X99521|TAX99521_1 aspartate aminotransferase from Thermus aquaticus (383 aa), FASTA scores: opt: 702, E(): 0, (34.9% identity in 393 aa overlap); etc. Also similar to other putative aminotransferases from Mycobacterium tuberculosis e.g. Rv2294, Rv3565, etc. Q7U135 No intermediary metabolism and respiration Rv0858c NC_002945.3 Mycobrowser_v2 CDS 955831 957042 . + 0 Mb0882 fadA POSSIBLE ACYL-COA THIOLASE FADA Mb0882, fadA, len: 403 aa. Equivalent to Rv0859,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 403 aa overlap). Possible fadA,acyl-CoA thiolase (EC 2.3.1.-), equivalent to NP_302423.1|NC_002677 putative beta-ketoadipyl CoA thiolase from Mycobacterium leprae (403 aa). Also highly similar to acyl/acetyl-CoA thiolases and beta-ketoadipyl CoA thiolases, e.g. T35428 probable acetyl CoA acetyltransferase (thiolase) from Streptomyces coelicolor (404 aa); NP_250427.1|NC_002516 probable acyl-CoA thiolase from Pseudomonas aeruginosa (401 aa); NP_106253.1|NC_002678 probable acyl-CoA thiolase from Mesorhizobium loti (402 aa); NP_248919.1|NC_002516|PcaF beta-ketoadipyl CoA thiolase PcaF from Pseudomonas aeruginosa (401 aa); etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiolases signature 2 and PS00099 Thiolases active site. Q7U134 No lipid metabolism Rv0859 NC_002945.3 Mycobrowser_v2 CDS 957047 959209 . + 0 Mb0883 fadB PROBABLE FATTY OXIDATION PROTEIN FADB Mb0883, fadB, len: 720 aa. Equivalent to Rv0860,len: 720 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 720 aa overlap). Probable fadB, fatty oxidation protein, equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Also highly similar to others and various proteins involved in fatty acid metabolism, e.g. T35429 probable fatty oxidation protein from Streptomyces coelicolor (733 aa); NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (714 aa); NP_418895.1|NC_002696 fatty oxidation complex alpha subunit from Caulobacter crescentus (709 aa); P40939|ECHA_HUMAN TRIFUNCTIONAL ENZYME ALPHA SUBUNIT [INCLUDES: LONG-CHAIN ENOYL-COA HYDRATASE (EC 4.2.1.17); LONG CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (EC 1.1.1.35)] from Homo sapiens (763 aa), FASTA scores: opt: 1176, E(): 0, (32.4% identity in 722 aa overlap); P21177|FADB_ECOLI FATTY OXIDATION COMPLEX ALPHA SUBUNIT [INCLUDES: ENOYL-COA HYDRATASE (EC 4.2.1.17); DELTA(3)-CIS-DELTA(2)-TRANS-ENOYL-COA ISOMERASE (EC 5.3.3.8); 3-HYDROXYACYL-COA DEHYDROGENASE (EC 1.1.1.35); 3-HYDROXYBUTYRYL-COA EPIMERASE (EC 5.1.2.3)] from Escherichia coli strain K12 (729 aa), FASTA scores: opt: 873, E(): 0, (33.6% identity in 693 aa overlap); etc. Q7U133 No lipid metabolism Rv0860 NC_002945.3 Mycobrowser_v2 CDS 959277 960905 . - 0 Mb0884c ercc3 dna helicase ercc3 Mb0884c, -, len: 542 aa. Equivalent to Rv0861c,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 542 aa overlap). Probable DNA helicase (EC 3.6.1.-), equivalent to NP_302420.1|NC_002677 probable DNA helicase from Mycobacterium leprae (549 aa). Also highly similar to others (shorter than several eukaryotic enzymes) e.g. NP_218820.1|NC_000919|AE001217|AE0 01217_6 putative DNA repair helicase from Treponema pallidum (606 aa), FASTA scores: opt: 1275, E(): 0, (47.5% identity in 592 aa overlap); Q00578|RA25_YEAST DNA REPAIR HELICASE from Saccharomyces cerevisiae (843 aa), FASTA scores: opt: 777, E(): 0, (30.4% identity in 605 aa overlap); P49135|XPB_MOUSE DNA-REPAIR PROTEIN COMPLEMENTING XP-B CELLS from Mus musculus (Mouse) (783 aa), FASTA scores: opt: 761, E(): 0, (36.3% identity in 375 aa overlap); etc. SEEMS TO BELONG TO THE HELICASE FAMILY. Q7U132 No information pathways Rv0861c NC_002945.3 Mycobrowser_v2 CDS 961043 963313 . - 0 Mb0885c conserved protein Mb0885c, -, len: 756 aa. Equivalent to Rv0862c,len: 756 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 756 aa overlap). Conserved hypothetical protein, equivalent to NP_302419.1|NC_002677 possible DNA-binding protein from Mycobacterium leprae (753 aa); and highly similar (except in C-terminus) to MLCB57.01|Z99494|T45333 hypothetical protein from Mycobacterium leprae (>577 aa, truncated), FASTA scores: opt: 3047, E(): 0, (78.9% identity in 578 aa overlap). Also similar in part to SCD12A.03c|AB93395.1|AL357524 hypothetical protein from Streptomyces coelicolor (867 aa). Q7U131 No conserved hypotheticals Rv0862c NC_002945.3 Mycobrowser_v2 CDS 963665 964093 . + 0 Mb0888 moaC2 probable molybdenum cofactor biosynthesis protein c 2 moac2 Mb0888, moaC2, len: 142 aa. Similar to Rv0864, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable moaC2,molybdopterin cofactor biosynthesis protein, highly similar to others e.g. CAB59676.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (170 aa); NP_418834.1|NC_002696 molybdenum cofactor biosynthesis protein C from Caulobacter crescentus (186 aa); Y10817|ANY10817_3|T44852 molybdopterin co-factor synthesis protein moaC from Arthrobacter nicotinovorans plasmid pAO1 (169 aa), FASTA scores: opt: 491, E(): 2.4e-29, (51.0% identity in 151 aa overlap); etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 491, E(): 2.4e-29, (54.9% identity in 153 aa overlap); and O53376|Rv3324c|MOAC3|MTV016.24c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C3 (177 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. X2BG23,P0A5K7 No NC_002945.3 Mycobrowser_v2 CDS 964090 964572 . + 0 Mb0889 mog probable molybdopterin biosynthesis mog protein Mb0889, mog, len: 160 aa. Equivalent to Rv0865,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Probable mog,molybdopterin biosynthesis MOG protein, highly similar or similar to other molybdenum cofactor biosynthesis proteins e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa); CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa); P44645|MOG_HAEIN|MOGA|HI0336 MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Haemophilus influenzae (197 aa), FASTA scores: opt: 306, E(): 9e-13,(39.6% identity in 139 aa overlap); P28694|MOG_ECOLI MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Escherichia coli (195 aa), FASTA scores: opt: 265, E(): 3.6e-10, (34.2 identity in 146 aa overlap); etc. Also highly similar to Rv0984|MTV044.12|MOAB2 POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis (181 aa). Q7U129 No intermediary metabolism and respiration Rv0865 NC_002945.3 Mycobrowser_v2 CDS 1078830 1079126 . + 0 Mb0993 conserved protein Mb0993, -, len: 98 aa. Equivalent to Rv0968, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 98 aa overlap). Conserved hypothetical protein, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). X2BGN3 No conserved hypotheticals Rv0968 NC_002945.3 Mycobrowser_v2 CDS 964569 964994 . + 0 Mb0890 moaE2 probable molybdenum cofactor biosynthesis protein e2 moae2 (molybdopterin converting factor large subunit) (molybdopterin [mpt] converting factor, subunit 2) Mb0890, moaE2, len: 141 aa. Equivalent to Rv0866,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Probable moaE2,molybdopterin converting factor E (molybdopterin converting factor (subunit 2)), similar to others e.g. Y10817|ANY10817_4|T44853 molybdopterin biosynthesis protein E chain from Arthrobacter nicotinovorans plasmid pAO1 (155 aa), FASTA scores: opt: 460, E(): 3.5e-27, (49.3 identity in 146 aa overlap); CAC01331.1|AL390968 moaE-like protein from Streptomyces coelicolor (152 aa); NP_389313.1|NC_000964 molybdopterin converting factor (subunit 2) from Bacillus subtilis (157 aa); etc. Also highly similar to Rv3119|MOAE1|Z95150|MTCY164_30 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 321, E(): 5.9e-17, (40.9% identity in 132 aa overlap); and O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa). Q7TTR9 No NC_002945.3 Mycobrowser_v2 CDS 965012 965995 . - 0 Mb0891c rpfA POSSIBLE RESUSCITATION-PROMOTING FACTOR RPFA Mb0891c, rpfA, len: 327 aa. Equivalent to Rv0867c,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(). Possible rpfA, resuscitation-promoting factor (see citation below). N-terminus highly similar to N-terminal part (1-125 aa) of Z99494|MLCB57_3|NP_302417.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (174 aa), FASTA scores: opt: 785, E(): 1.8e-18, (63.0% identity in 200 aa overlap); and highly similar to C-terminus of NP_301299.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (375 aa); and middle part of NP_302360.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (157 aa). N-terminus also highly similar in part of three secreted proteins from Streptomyces coelicolor e.g. CAC09538.1|AL442120 putative secreted protein (244 aa). Regions highly similar to CAB76321.1|AL158060 putative membrane protein from Streptomyces coelicolor (121 aa); and middle part of CAB09664.1|Z96935 rpf from Micrococcus luteus (220 aa). Also highly similar in part to four resuscitation-promoting factors from Mycobacterium tuberculosis: Rv2450 (172 aa), Rv1009 (362 aa), Rv1884c (176 aa), and Rv2389c (154 aa). Contains a probable secretory signal sequence in N-terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (327 aa versus 407 aa). Q7U128 No NC_002945.3 Mycobrowser_v2 CDS 1027570 1028151 . + 0 Mb0945 POSSIBLE RESOLVASE Mb0945, -, len: 193 aa. Equivalent to Rv0921, len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 193 aa overlap). Possible resolvase for IS1535, highly similar to many bacterial resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 537, E(): 5.7e-29, (51.8% identity in 166 aa overlap). Presents an helix turn helix motif. Q7U109 No insertion seqs and phages Rv0921 NC_002945.3 Mycobrowser_v2 CDS 1185331 1186188 . + 0 Mb1091 CONSERVED HYPOTHETICAL PROTEIN Mb1091, -, len: 285 aa. Equivalent to Rv1062, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 285 aa overlap). Conserved hypothetical protein, some similarity to AL079356|SC6G9_10 hypothetical protein in Streptomyces coelicolor (289 aa), FASTA scores: opt: 556, E(): 1.2e-27, (39.0% identity in 287 aa overlap), and Z99111|BSUB0008_176 Bacillus subtilis (260 aa), FASTA scores: opt: 163, E(): 0.0013, (27.4% identity in 179aa overlap) Q7U0R4 No conserved hypotheticals Rv1062 NC_002945.3 Mycobrowser_v2 CDS 966443 966721 . - 0 Mb0892c moaD2 probable molybdenum cofactor biosynthesis protein d 2 moad2 (molybdopterin converting factor small subunit) (molybdopterin [mpt] converting factor, subunit 1) Mb0892c, moaD2, len: 92 aa. Equivalent to Rv0868c,len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Probable moaD2,molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to CAB88494.1|AL353816 putative molybdopterin converting factor from Streptomyces coelicolor (84 aa); and weakly similar to others MoaD proteins e.g. Z99111|BSUB0008_103 from Bacillus subtilis (77 aa), FASTA scores: opt: 86,E(): 2.8, (22.9% identity in 83 aa overlap); etc. Also some similarity with Rv3112|MOAD1|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 113, E(): 0.024, (31.3% identity in 83 aa overlap). Q7TTR8 No NC_002945.3 Mycobrowser_v2 CDS 966725 967807 . - 0 Mb0893c moaA2 probable molybdenum cofactor biosynthesis protein a2 moaa2 Mb0893c, moaA2, len: 360 aa. Equivalent to Rv0869c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 360 aa overlap). Probable moaA2,molybdenum cofactor biosynthesis protein, highly similar to others e.g. CAB59437.1|AL132644|SCI8_6 molybdenum cofactor biosynthesis protein A from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1336, E(): 0,(61.7% identity in 332 aa overlap); S57490|X78980|ANMOAA_1 molybdopterin cofactor synthesis protein from Arthrobacter nicotinovorans (fragment) (374 aa), FASTA scores: opt: 1059, E(): 0, (49.9% identity in 369 aa overlap); Q44118|MOAA_ARTNI PROBABLE MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A from Arthrobacter nicotinovorans plasmid pAO1 (355 aa); etc. Also similar to Rv3109|MTCY164.19|Z95150|MOAA1 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 657, E(): 0,(36.6% identity in 309 aa overlap). BELONGS TO THE MOAA / NIFB / PQQE FAMILY. X2BG27,P65385 No NC_002945.3 Mycobrowser_v2 CDS 967804 968193 . - 0 Mb0894c POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0894c, -, len: 129 aa. Equivalent to Rv0870c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 129 aa overlap). Possible conserved integral membrane protein, highly similar to other membrane proteins: putative secreted proteins or hypothetical proteins e.g. CAC08263.1| AL392146 putative integral membrane protein from Streptomyces coelicolor (138 aa); NP_233433.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (143 aa); NP_455572.1|NC_003198 putative membrane protein from Salmonella enterica subsp. enterica serovar Typhi (148 aa); P37065|YCCF_ECOLI HYPOTHETICAL 16.3 KD PROTEIN from Escherichia coli (148 aa), FASTA scores: opt: 183, E(): 1.9e-06, (36.6% identity in 134 aa overlap); etc. Q7U127 No cell wall and cell processes Rv0870c NC_002945.3 Mycobrowser_v2 CDS 968358 968765 . + 0 Mb0895 cspB PROBABLE COLD SHOCK-LIKE PROTEIN B CSPB Mb0895, cspB, len: 135 aa. Equivalent to Rv0871,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Probable cspB, cold shock-like protein B, equivalent to Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from Mycobacterium leprae (136 aa), FASTA scores: opt: 787,E(): 0, (86.0% identity in 136 aa overlap). Also highly similar (but often longer than) to others e.g. CAB93399.1|AL357524 cold shock protein B from Streptomyces coelicolor (127 aa); Q45099|CSPD_BACCE COLD SHOCK-LIKE PROTEIN CSPD from Bacillus cereus (66 aa); Y101 81|LLCSPB_1 cold shock protein from Lactococcus lactis (66 aa), FASTA scores: opt: 220, E(): 2.5e-07, (48.3% identity in 60 aa overlap); etc. SEEMS TO BELONG TO THE COLD-SHOCK DOMAIN (CSD) FAMILY. Q7U126 No virulence, detoxification, adaptation Rv0871 NC_002945.3 Mycobrowser_v2 CDS 968884 970710 . - 0 Mb0896c PE_PGRS15 pe-pgrs family protein pe_pgrs15 Mb0896c, PE_PGRS15, len: 608 aa. Equivalent to Rv0872c, len: 606 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 606 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see first citation below),similar to many e.g. MTCY24A1.04c|Z95207 (615 aa), FASTA scores: opt: 2636, E(): 0, (64.6% identity in 619 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp in-frame deletion and a 9 bp in-frame insertion leads to a lightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (608 aa versus 606 aa). Q7U125 No NC_002945.3 Mycobrowser_v2 CDS 980971 981732 . - 0 Mb0907c CONSERVED HYPOTHETICAL PROTEIN Mb0907c, -, len: 253 aa. Equivalent to Rv0883c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 253 aa overlap). Conserved hypothetical protein, equivalent to O3306|MLCB57_16 CONSERVED HYPOTHETICAL PROTEI from Mycobacterium leprae (251 aa), FASTA scores: E(): 0, (79.4% identity in 253 aa overlap). Also highly similar to N_terminus of AL009204|SC9B10_22 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (352 aa), FASTA scores: E(): 6.1e-20, (35.0% identity in 246 aa overlap). X2BGF0 No conserved hypotheticals Rv0883c NC_002945.3 Mycobrowser_v2 CDS 970971 972923 . + 0 Mb0897 fadE10 PROBABLE ACYL-COA DEHYDROGENASE FADE10 Mb0897, fadE10, len: 650 aa. Equivalent to Rv0873,len: 650 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 650 aa overlap). Probable fadE10,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB91129.1|AL355913 putative acyl CoA dehydrogenase from Streptomyces coelicolor (658 aa); P50544|ACDV_MOUSE ACYL-COA DEHYDROGENASE from Mus musculus (656 aa); D30647|RATVLCAD_1 very-long-chain Acyl-CoA dehydrogenase from Rattus norvegicus (655 aa), FASTA scores: opt: 675, E(): 0, (33.9% identity in 380 aa overlap); etc. X2BGE3,P63430 No NC_002945.3 Mycobrowser_v2 CDS 973012 974172 . - 0 Mb0898c CONSERVED HYPOTHETICAL PROTEIN Mb0898c, -, len: 386 aa. Equivalent to Rv0874c,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Conserved hypothetical protein, highly similar in part to SPU62616_1 hypothetical protein from Synechococcus sp. (280 aa),FASTA scores: E(): 6.3e-26, (35.2% identity in 264 aa overlap); SYCSLLLH_102 from Synechocystis sp. (447 aa),FASTA scores: E(): 1.1e-18, (29.5% identity in 400 aa overlap). Also highly similar to Rv0628c|MTCY20H10_9 from Mycobacterium tuberculosis (383 aa), FASTA scores: E():0,(81.5% identity in 383 aa overlap). X2BG28,P0A5D4 No conserved hypotheticals Rv0874c NC_002945.3 Mycobrowser_v2 CDS 974272 974760 . - 0 Mb0899c POSSIBLE CONSERVED EXPORTED PROTEIN Mb0899c, -, len: 162 aa. Equivalent to Rv0875c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible conserved exported protein, equivalent to MLCB57_11|O33056 possible exported protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 789, E(): 0, (71.4% identity in 161 aa overlap). X2BGA5 No cell wall and cell processes Rv0875c NC_002945.3 Mycobrowser_v2 CDS 974757 976403 . - 0 Mb0900c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0900c, -, len: 548 aa. Equivalent to Rv0876c,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Possible conserved transmembrane protein, equivalent to MLCB57_12|O33057 possible membrane protein from Mycobacterium leprae (579 aa), FASTA scores: opt: 2850, E(): 0, (81.0% identity in 568 aa overlap). Also highly similar (except in N-terminus) to CAB93403.1|AL357524 putative integral membrane protein from Streptomyces coelicolor (463 aa). Q7U124 No cell wall and cell processes Rv0876c NC_002945.3 Mycobrowser_v2 CDS 976541 977329 . + 0 Mb0901 CONSERVED HYPOTHETICAL PROTEIN Mb0901, -, len: 262 aa. Equivalent to Rv0877, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Conserved hypothetical protein, equivalent to MLCB57_13|O33058 conserved hypothetical protein from Mycobacterium leprae (269 aa), FASTA scores: E(): 0, (80.5% identity in 257 aa overlap). Also highly similar (except in C-terminus) to SCD12A.13|CAB93404.1|AL357524 hypothetical protein from Streptomyces coelicolor (308 aa). X2BGF3 No conserved hypotheticals Rv0877 NC_002945.3 Mycobrowser_v2 CDS 977352 978668 . - 0 Mb0902c PPE13 ppe family protein ppe13 Mb0902c, PPE13, len: 438 aa. Equivalent to Rv0878c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. P4261|YHS6_MYCTU (517 aa), FASTA scores: opt: 1044, E(): 0, (47.4% identity in 397 aa overlap); MTV014_3, MTCI65_2, MTCY98_24, MTCY3C7_23, MTCY48_17,MTV004_5, MTV004_3, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (a-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Q7U123 No NC_002945.3 Mycobrowser_v2 CDS 978946 979221 . - 0 Mb0903c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Mb0903c, -, len: 91 aa. Equivalent to Rv0879c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Possible conserved transmembrane protein, C-terminus highly similar to C-terminal part of MLCB57_14|O33059 conserved hypothetical protein from Mycobacterium leprae (91 aa), FASTA scores: E(): 1.2e-25, (76.9% identity in 91 aa overlap). X2BG33,P64736 No cell wall and cell processes Rv0879c NC_002945.3 Mycobrowser_v2 CDS 979399 979830 . + 0 Mb0904 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY MARR-FAMILY) Mb0904, -, len: 143 aa. Equivalent to Rv0880, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Possible transcriptional regulator, MarR family, equivalent to MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 818, E(): 0, (89.5% identity in 143 aa overlap). Also similar to many others e.g. CAB93410.1|AL357524 putative marR-family protein from Streptomyces coelicolor (145 aa); NP_251757.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (147 aa); etc. Also similar to Rv2327 from Mycobacterium tuberculosis (163 aa). X2BGB0,P67746 No regulatory proteins Rv0880 NC_002945.3 Mycobrowser_v2 CDS 987698 989170 . + 0 Mb0912 PROBABLE EXPORTED PROTEIN Mb0912, -, len: 490 aa. Equivalent to Rv0888, len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 490 aa overlap). Probable exported protein. Equivalent to AAK45157.1 from Mycobacterium tuberculosis strain CDC1551 (507 aa) but shorter 17 aa. Contains possible N-terminal signal sequence. X2BGF4,P64744 No cell wall and cell processes Rv0888 NC_002945.3 Mycobrowser_v2 CDS 979827 980693 . + 0 Mb0905 POSSIBLE RRNA METHYLTRANSFERASE (RRNA METHYLASE) Mb0905, -, len: 288 aa. Equivalent to Rv0881, len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 288 aa overlap). Possible rRNA methyltransferase (EC 2.1.1.-), highly similar to others and hypothetical proteins e.g. CAB76071.1|AL157953 putative rRNA methylase from Streptomyces coelicolor (272 aa); NP_421117.1|NC_002696 spoU rRNA methylase family protein from Caulobacter crescentus (268 aa); D90913_93|P74261 rRNA METHYLASE from Synechocystis sp. (274 aa), FASTA scores: E(): 1.1e-13, (26.3% identity in 278 aa overlap); P18644|TSNR_STRCN rRNA METHYLTRANSFERASE (EC 2.1.1.66) from Streptomyces cyaneus (Streptomyces curacoi) (269 aa), FASTA scores: E(): 3.7e-08, (23.9% identity in 268 aa overlap); etc. Equivalent to AAK45146.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 46 aa. X2BGE2,P59968 No intermediary metabolism and respiration Rv0881 NC_002945.3 Mycobrowser_v2 CDS 980690 980974 . + 0 Mb0906 PROBABLE TRANSMEMBRANE PROTEIN Mb0906, -, len: 94 aa. Equivalent to Rv0882, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Probable transmembrane protein. X2BGF8,P64738 No cell wall and cell processes Rv0882 NC_002945.3 Mycobrowser_v2 CDS 981889 983019 . - 0 Mb0908c serC POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC (PSAT) Mb0908c, serC, len: 376 aa. Equivalent to Rv0884c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible serC,phosphoserine aminotransferase (EC 2.6.1.52), equivalent to MLCB57_17 putative phosphoserine aminotransferase from Mycobacterium leprae (376 aa), FASTA scores: E(): 0, (87.5 identity in 376 aa overlap). Also highly similar to CAC08322.1|AL392149 putative aminotransferase from Streptomyces coelicolor (363 aa); and similar to other phosphoserine aminotransferases e.g. NP_386837.1|NC_003047 PUTATIVE PHOSPHOSERINE AMINOTRANSFERASE PROTEIN from Sinorhizobium meliloti (392 aa); P52878|SERC_METBA PHOSPHOSERINE AMINOTRANSFERASE from Methanosarcina barkeri (370 aa); P10658|SERC_RABIT|RABEPIP_1 PHOSPHOSERINE AMINOTRANSFERASE from Rabbit (370 aa), FASTA scores: opt: 271, E(): 3.5e-11, (24.5% identity in 368 aa overlap); etc. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE. X2BG34,P63515 No NC_002945.3 Mycobrowser_v2 CDS 983227 984249 . + 0 Mb0909 CONSERVED HYPOTHETICAL PROTEIN Mb0909, -, len: 340 aa. Equivalent to Rv0885, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Conserved hypothetical protein, equivalent to O33063|MLCB57_18 possible transmembrane protein from Mycobacterium leprae (341 aa), FASTA score: (83.9% identity in 341 aa overlap). Also similar except in C-terminus to T35630 probable membrane protein from Streptomyces coelicolor (312 aa). X2BGB3,P0A5D6 No conserved hypotheticals Rv0885 NC_002945.3 Mycobrowser_v2 CDS 984268 985995 . + 0 Mb0910 fprB PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) Mb0910, fprB, len: 575 aa. Equivalent to Rv0886,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 575 aa overlap). Probable fprB,ferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin oxidoreductase) (EC 1.18.1.2), equivalent to O3306|MLCB57_19 FERREDOXIN/FERREDOXIN--NADP REDUCTASE from Mycobacterium leprae (555 aa), FASTA scores: E(): 0, (76.6 identity in 560 aa overlap). Also highly similar or similar to others e.g. NP_294219.1|NC_001263 putative ferredoxin/ferredoxin--NADP reductase from Deinococcus radiodurans (479 aa) (N-terminus shorter); P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from homo sapiens (497 aa), FASTA scores: opt: 624, E(): 3e-30,(39.7% identity in 484 aa overlap); P08165|ADRO_BOVIN NADPH:ADRENODOXIN OXIDOREDUCTASE from Bos taurus (492 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv3106, Rv3858c, etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. X2BGE5,P65529 No intermediary metabolism and respiration Rv0886 NC_002945.3 Mycobrowser_v2 CDS 985978 986436 . - 0 Mb0911c CONSERVED HYPOTHETICAL PROTEIN Mb0911c, -, len: 152 aa. Equivalent to Rv0887c,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (194 aa), FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity in 131 aa overlap); etc. Also shows weak similarity with transposases and related proteins. X2BGG3 No conserved hypotheticals Rv0887c NC_002945.3 Mycobrowser_v2 CDS 989205 990326 . - 0 Mb0913c citA PROBABLE CITRATE SYNTHASE II CITA Mb0913c, citA, len: 373 aa. Equivalent to Rv0889c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Probable citA (alternate gene name: gltA), citrate synthase 2 (EC 4.1.3.7), highly similar to others e.g. CAB95899.1|AL359988 putative citrate synthase from Streptomyces coelicolor (387 aa); P39119|CISY_BACSU citrate synthase II from Bacillus subtilis (366 aa), FASTA scores: opt: 586, E(): 5.8e-30, (33.8% identity in 367 aa overlap); etc. Also similar to Rv0896|MTCY31.24 from Mycobacterium tuberculosis (29.2% identity in 274 aa overlap) and Rv1131. Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY. X2BG39,P63778 No NC_002945.3 Mycobrowser_v2 CDS 993063 993920 . - 0 Mb0915c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb0915c, -, len: 285 aa. Equivalent to Rv0891c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Possible transcriptional regulator, highly similar in N-terminus to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar to several Mycobacterium tuberculosis putative transcriptional regulators e.g. Q1102|MTCY02B10_22 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (1159 aa),FASTA scores: opt: 702, E(): 8.3e-40, (50.6% identity in 247 aa overlap); MTV036_21; MTV008_44; MTCY02B10_23. Also shows similarity with several adenylate cyclases and hydrolases from other organisms. X2BGE9,P59970 No regulatory proteins Rv0891c NC_002945.3 Mycobrowser_v2 CDS 994318 995805 . + 0 Mb0916 PROBABLE MONOOXYGENASE Mb0916, -, len: 495 aa. Equivalent to Rv0892, len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Probable monooxygenase (EC 1.14.-.-), highly similar to others e.g. NP_250787.1|NC_002516 probable flavin-binding monooxygenase from Pseudomonas aeruginosa (491 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); P12015|CYMO_ACIS cyclohexanone monooxygenase from Acinetobacter sp. (542 aa), FASTA scores: opt: 489, E(): 6.8e-26, (30.3% identity in 492 aa overlap); etc. Also highly similar to Rv0565c, Rv3854c,Rv3083, etc from Mycobacterium tuberculosis. Has hydrophobic stretch at N-terminus. X2BGG8,P64746 No intermediary metabolism and respiration Rv0892 NC_002945.3 Mycobrowser_v2 CDS 1173329 1174234 . + 0 Mb1079 PROBABLE OXIDOREDUCTASE Mb1079, -, len: 301 aa. Equivalent to Rv1050, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). Probable oxidoreductase (EC 1.-.-.-) similar to many e.g. Rv1543|MTCY48.22C|Q10783 PUTATIVE OXIDOREDUCTASE CY48.22C (341 aa), FASTA scores: opt: 462, E(): 3e-22, (33.6% identity in 265 aa overlap). Q7U0S6 No intermediary metabolism and respiration Rv1050 NC_002945.3 Mycobrowser_v2 CDS 995783 996760 . - 0 Mb0917c possible s-adenosylmethionine-dependent methyltransferase Mb0917c, -, len: 325 aa. Equivalent to Rv0893c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 325 aa overlap). Conserved hypothetical protein, belongs in family with P96823|Rv0146|MTCI5.20 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 784, E(): 0, (43.2% identity in 308 aa overlap); Rv0726c,Rv0731c, Rv3399, etc. Also shows some similarity with others e.g. SC9B5.10|T35930 hypothetical protein from Streptomyces coelicolor (303 aa); BSUB0008_141|Q45500 HYPOTHETICAL 34.8 KD PROTEIN from Bacillus subtilis (304 aa), FASTA scores: E(): 0.00033, (26.8% identity in 168 aa overlap); etc. X2BGF9,P64748 No lipid metabolism Rv0893c NC_002945.3 Mycobrowser_v2 CDS 2078001 2078264 . - 0 Mb1870c vapb13 possible antitoxin vapb13 Mb1870c, -, len: 87 aa. Equivalent to Rv1839c, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Conserved hypothetical protein. Some similarity to G217008 CHO-ORF1 (279 aa),FASTA scores: opt: 86, E(): 13, (38.7% identity in 62 aa overlap). Q7TZG5 No virulence, detoxification, adaptation Rv1839c NC_002945.3 Mycobrowser_v2 CDS 996989 998170 . + 0 Mb0918 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY LUXR-FAMILY) Mb0918, -, len: 393 aa. Equivalent to Rv0894, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Possible regulatory protein, LuxR family, highly similar in part to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar to others e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); NP_107293.1|NC_002678 transcriptional regulator from Mesorhizobium loti (903 aa); etc. Also similar to other regulatory proteins from Mycobacterium tuberculosis e.g. Rv2488c|MTV008_44 (1137 aa), FASTA score: (53.2% identity in 363 aa overlap); Rv1358|MTCY02B10_22 (1159 aa), FASTA score: (52.3% identity in 365 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). X2BG43,P64750 No regulatory proteins Rv0894 NC_002945.3 Mycobrowser_v2 CDS 2507582 2508037 . - 0 Mb2278c Probable integral membrane protein Mb2278c, -, len: 151 aa. Equivalent to Rv2254c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 151 aa overlap). Probable integral membrane protein. Q7VEM8 No cell wall and cell processes Rv2254c NC_002945.3 Mycobrowser_v2 CDS 998247 999764 . + 0 Mb0919 possible triacylglycerol synthase (diacylglycerol acyltransferase) Mb0919, -, len: 505 aa. Equivalent to Rv0895, len: 505 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 505 aa overlap). Conserved hypothetical protein; member of family with: Rv3740c,Rv3734c, Rv1425, Rv1760, etc. Shows some similarity with NP_301898.1|NC_002677 conserved membrane protein from Mycobacterium leprae (491 aa). X2BGC4,P67205 No lipid metabolism Rv0895 NC_002945.3 Mycobrowser_v2 CDS 999937 1001232 . + 0 Mb0920 gltA2 PROBABLE CITRATE SYNTHASE I GLTA2 Mb0920, gltA2, len: 431 aa. Equivalent to Rv0896,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8%% identity in 431 aa overlap). Probable gltA2,citrate synthase 1 (EC 4.1.3.7), highly similar to O33066|NP_302405.1|NC_002677 citrate synthase 1 from Mycobacterium leprae (431 aa), FASTA scores: E(): 0, (91.0 identity in 431 aa overlap); and AAF04133.1|AF191033_1|AF191033 citrate synthase from Mycobacterium smegmatis (441 aa). Also highly similar to others e.g. AAF14286.1|AF181118_1|AF181118 citrate synthase from Streptomyces coelicolor (429 aa); P42457|CISY_CORGL CITRATE SYNTHASE from Corynebacterium glutamicum (437 aa), FASTA scores: opt: 1847, E(): 0,(63.0% identity in 433 aa overlap); etc. Also similar to two other Mycobacterium tuberculosis citrate synthases,Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (29.2% identity in 274 aa overlap) and Rv1131|MTCY22G8.20|gltA1 (393 aa). Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY. Q7U122 No NC_002945.3 Mycobrowser_v2 CDS 1001273 1002880 . - 0 Mb0921c PROBABLE OXIDOREDUCTASE Mb0921c, -, len: 535 aa. Equivalent to Rv0897c,len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 535 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases from diverse organisms e.g. CAB94055.1|AL358672 putative oxidoreductase from Streptomyces coelicolor (540 aa); NP_147877.1|NC_000854 phytoene dehydrogenase from Aeropyrum pernix (549 aa); Q01671|CRTD_RHOSH methoxyneurosporene dehydrogenase from Rhodobacter sphaeroides (495 aa), FASTA scores: opt: 139, E(): 2.6e-06, (23.8% identity in 538 aa overlap); etc. Also similar to Rv1432, Rv2997, and Rv3829c from Mycobacterium tuberculosis. X2BGH3,P64752 No intermediary metabolism and respiration Rv0897c NC_002945.3 Mycobrowser_v2 CDS 1003277 1004257 . + 0 Mb0923 ompA outer membrane protein a ompa Mb0923, ompA, len: 326 aa. Equivalent to Rv0899,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable ompA, outer membrane protein A, C-terminal region similar to C-terminus of many members of the OMPA family of outer membrane proteins e.g. NP_458280.1|NC_003198 putative outer membrane protein from Salmonella enterica subsp. enterica serovar Typhi (220); NP_418008.1|NC_000913 putative outer membrane protein from Escherichia coli strain K12 (219 aa), FASTA scores: opt: 296, E(): 2.2e-11,(45.3% identity in 117 aa overlap); NP_231844.1|NC_002505 outer membrane protein OmpA from Vibrio cholerae (321 aa); Q05146|OMPA_BORAV OUTER MEMBRANE PROTEIN A PRECURSOR from Bordetella avium (194 aa); etc. A signal peptide sequence probably exists at the N-terminus. Contains PS00044 Bacterial regulatory proteins, lysR family signature. BELONGS TO THE OMPA FAMILY. X2BG45,P65594 No cell wall and cell processes Rv0899 NC_002945.3 Mycobrowser_v2 CDS 1004270 1004422 . + 0 Mb0924 POSSIBLE MEMBRANE PROTEIN Mb0924, -, len: 50 aa. Equivalent to Rv0900, len: 50 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 50 aa overlap). Possible membrane protein,with hydrophobic domain from aa 4-26. X2BGD0,P64756 No cell wall and cell processes Rv0900 NC_002945.3 Mycobrowser_v2 CDS 1004422 1004949 . + 0 Mb0925 POSSIBLE CONSERVED EXPORTED OR MEMBRANE PROTEIN Mb0925, -, len: 175 aa. Equivalent to Rv0901, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 175 aa overlap). Possible conserved exported or membrane protein, with hydrophobic N-terminus at aa 7-25. Shows some similarity in C-terminus to O33070|Z99494|MLCB57.59 HYPOTHETICAL PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 204,E(): 3.2e-12, (44.9% identity in 78 aa overlap) X2BGG0,P64758 No cell wall and cell processes Rv0901 NC_002945.3 Mycobrowser_v2 CDS 1216207 1216512 . + 0 Mb1118 PE10 pe family protein pe10 Mb1118, PE10, len: 101 aa. Equivalent to Rv1089,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 101 aa overlap). Member of the Mycobacterium tuberculosis PE family of glycine-rich proteins. Partial ORF that appears to be frameshifted,continuation of Rv1088|MTV017.41. Sequence has been checked and appears correct. Similar to Z95555|MTCY06F7_4 Mycobacterium tuberculosis cosmid (401 aa), FASTA scores: opt: 126, E(): 2, (29.6% identity in 125 aa overlap). Q7U0P4 No PE/PPE Rv1089 NC_002945.3 Mycobrowser_v2 CDS 1004966 1006306 . - 0 Mb0926c prrB TWO COMPONENT SENSOR HISTIDINE KINASE PRRB Mb0926c, prrB, len: 446 aa. Equivalent to Rv0902c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 446 aa overlap). prrB, two-component sensor histidine kinase (EC 2.7.3.-) (see citations below), transmembrane protein, equivalent to MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase from Mycobacterium leprae (446 aa); and similar at C-termini to NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa). C-terminus also similar to the C-termini of many sensor-like histidine kinase proteins e.g. P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor protein from Escherichia coli strain K12 (457 aa), FASTA scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa overlap); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (483 aa); CAB82845.1|AJ277081 putative histidine kinase from Amycolatopsis mediterranei (472 aa); etc. Also similar in part to Mycobacterium tuberculosis proteins Rv3764c (475 aa); and Rv0982 (504 aa). Thought to be induced at phagocytosis (see second citation below). X2BGH8,P0A5Z9 No NC_002945.3 Mycobrowser_v2 CDS 1006317 1007027 . - 0 Mb0927c prrA TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA Mb0927c, prrA, len: 236 aa. Equivalent to Rv0903c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). prrA, two-component response regulator (see citations below), equivalent to Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component response regulator from Mycobacterium leprae (233 aa),FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa overlap); and similar to T45446 probable two-component response regulator from Mycobacterium leprae (253 aa). Also similar to many sensor-like histidine kinase proteins e.g. CAB88489.1|AL353816 putative two-component systen response regulator from Streptomyces coelicolor (248 aa); AAG36759.1|AF119221_1 |AF119221 response regulator from Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM transcriptional activator protein COPR from Pseudomonas syringae (pv. tomato) (227 aa), FASTA scores: opt: 600,E(): 0, (44.4% identity in 225 aa overlap); etc. Also similar to Rv0981 from Mycobacterium tuberculosis (230 aa), Rv3765c (234 aa), phoP (247 aa), etc. Thought to be induced at phagocytosis (see second citation below). X2BGG9,P0A5Z7 No NC_002945.3 Mycobrowser_v2 CDS 1007158 1008645 . - 0 Mb0928c accD3 PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE (SUBUNIT BETA) ACCD3 (ACCASE BETA CHAIN) Mb0928c, accD3, len: 495 aa. Equivalent to Rv0904c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 495 aa overlap). Putative accD3,acetyl-CoA carboxylase carboxyl transferase, beta subunit (carboxyltransferase subunit of acetyl-CoA carboxylase) (EC 6.4.1.2), highly similar in part to AAA63045.1|U15184 zinc finger protein from Mycobacterium leprae (201 aa). Also highly similar to others e.g. CAC42827.1|Y17592 putative carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum (491 aa); CAB86110.1|AL163003 putative acetyl CoA carboxylase (alpha and beta subunits) from Streptomyces coelicolor (458 aa); Q54776|ACCD_SYNP7 ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Synechococcus sp. (305 aa); P12217|ACCD_MARPO ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Marchantia polymorpha (316 aa), FASTA scores: opt: 519, E():1.6e-24, (40.2% identity in 219 aa overlap); etc. Also similar to Rv3280, Rv2502c,etc from Mycobacterium tuberculosis. BELONGS TO THE ACCD/PCCB FAMILY. X2BG50,P63406 No NC_002945.3 Mycobrowser_v2 CDS 1008672 1009403 . + 0 Mb0929 echA6 POSSIBLE ENOYL-COA HYDRATASE ECHA6 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0929, echA6, len: 243 aa. Equivalent to Rv0905,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 243 aa overlap). Possible echA6,enoyl-CoA hydratase (EC 4.2.1.17), highly similar to ML15184|U15184 enoyl-CoA hydratase from Mycobacterium leprae (247 aa), FASTA score: (85.8% identity in 247 aa overlap). Also similar to many e.g. NP_250320.1|NC_002516 probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa (261 aa); NP_415911.1|NC_000913 putative enzyme from Escherichia coli strain K12 (255 aa); P24162 ECHH_RHOCA|FADB1 enoyl-CoA hydratase homolog from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores: opt: 404, E():7.8e-21, (37.3% identity in 249 aa overlap); etc. X2BGD6,P64015 No NC_002945.3 Mycobrowser_v2 CDS 1010650 1012200 . + 0 Mb0931 conserved protein Mb0931, -, len: 516 aa. Equivalent to Rv0907, len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 511 aa overlap). Conserved hypothetical protein, possibly involved in cell wall biosynthesis: similar to many beta-lactamases, penicillin-binding proteins and hypothetical proteins e.g. NP_298910.1|NC_002488 beta-lactamase from Xylella fastidiosa (455 aa); Q06317|PBP4_NOCLA PENICILLIN-BINDING PROTEIN 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E(): 8.8e-05, (28.7% identity in 401 aa overlap); etc. N-terminus highly similar to AAA63047.1|U15184 hypothetical protein from Mycobacterium leprae (58 aa). Related to other putative esterases and penicillin binding proteins in Mycobacterium tuberculosis e.g. Rv1730c|MTCY04C12.15c (517 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U121 No cell wall and cell processes Rv0907 NC_002945.3 Mycobrowser_v2 CDS 1012197 1014590 . + 0 Mb0932 ctpE PROBABLE METAL CATION TRANSPORTER ATPASE P-TYPE CTPE Mb0932, ctpE, len: 797 aa. Equivalent to Rv0908,len: 797 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 797 aa overlap). Probable ctpE, metal cation-transporting ATPase P-type, transmembrane protein,E1-E2 family, highly similar to many e.g. AB93406.1|AL357524 putative integral membrane ATPase from Streptomyces coelicolor (802 aa); NP_346063.1|NC_003028 cation-transporting ATPase (E1-E2 family) from Streptococcus pneumoniae (778 aa); P37278|ATCL_SYNP7|PACL cation-transporting atpase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (926 aa), FASTA scores: opt: 257, E(): 4.8e-33, (27.7% identity in 905 aa overlap); etc. Contains E1-E2 ATPases phosphorylation site (PS00154). BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). X2BGH4,P0A505 No cell wall and cell processes Rv0908 NC_002945.3 Mycobrowser_v2 CDS 1015147 1015326 . + 0 Mb0933 CONSERVED HYPOTHETICAL PROTEIN Mb0933, -, len: 59 aa. Equivalent to Rv0909, len: 59 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 59 aa overlap). Conserved hypothetical protein, equivalent to NP_302399.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (56 aa). Also some similarity with AL022268|SC4H2_10c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (97 aa), FASTA scores: opt: 106, E(): 0.13, (43.2% identity in 37 aa overlap). Q7U120 No conserved hypotheticals Rv0909 NC_002945.3 Mycobrowser_v2 CDS 1015864 1016637 . + 0 Mb0935 conserved protein Mb0935, -, len: 257 aa. Equivalent to Rv0911, len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Conserved hypothetical protein, showing similarity with hydroxylases and hypothetical proteins e.g. T35325 probable hydroxylase from Streptomyces coelicolor (265 aa); Q54242 hypothetical protein from Streptomyces, FASTA scores: opt: 372, E(): 8.8e-18, (32.0% identity in 256 aa overlap); AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV from Streptomyces peucetius (275 aa); AAA63051.1|U15184 hypothetical protein from Mycobacterium leprae (94 aa); etc. Also similar to Rv0577 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (261 aa). Q7U118 No conserved hypotheticals Rv0911 NC_002945.3 Mycobrowser_v2 CDS 1025963 1027282 . - 0 Mb0944c probable transposase Mb0944c, -, len: 439 aa. Equivalent to Rv0920c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Probable transposase for IS1554, highly similar to others e.g. MTCY441.35|Q45111 transposase from Mycobacterium tuberculosis (419 aa), FASTA scores: opt: 1113, E(): 0,(43.9% identity in 378 aa overlap); etc. Contains transposases mutator family signature (PS01007). Q7U110 No insertion seqs and phages Rv0920c NC_002945.3 Mycobrowser_v2 CDS 1017683 1019191 . - 0 Mb0937c POSSIBLE DIOXYGENASE Mb0937c, -, len: 502 aa. Equivalent to Rv0913c,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 502 aa overlap). Possible dioxygenase (EC 1.-.-.-), showing similarity with others e.g. AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage dioxygenase from Phaseolus vulgaris (543 aa); CAB56138.1|AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); AAK06796.1|AF324838_15|AF324838 putative dioxygenase SimC5 from Streptomyces antibioticus (456 aa); Q53353|S65040 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE (EC 1.13.11.43) from Pseudomonas paucimobilis (485 aa), FASTA scores: opt: 310,E(): 3.4e-20, (28.9% identity in 495 aa overlap); etc. Also some similarity with Rv0654|MTCI376.22 PROBABLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa). Q7U116 No intermediary metabolism and respiration Rv0913c NC_002945.3 Mycobrowser_v2 CDS 1019193 1020431 . - 0 Mb0938c POSSIBLE LIPID CARRIER PROTEIN OR KETO ACYL-COA THIOLASE Mb0938c, -, len: 412 aa. Equivalent to Rv0914c,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 412 aa overlap). Possible lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16), highly similar to NP_421905.1|NC_002696 thiolase family protein from Caulobacter crescentus (407 aa); and similar to others e.g. NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase from Mesorhizobium loti (392 aa); NP_385796.1|NC_003047 PUTATIVE 3-KETOACYL-COA THIOLASE PROTEIN from Sinorhizobium meliloti (389 aa); NP_275932.1|NC_000916 lipid-transfer protein (sterol or nonspecific) from Methanothermobacter thermautotrophicus (383 aa); AB55378.1|AL117263 possible 3-ketoacyl-CoA thiolase from Leishmania major (441 aa), FASTA scores: opt: 547, E(): 3.1e-26, (31.0% identity in 435 aa overlap); etc. Also similar to Rv2790c, Rv1627c, Rv0244, etc from Mycobacterium tuberculosis. COULD BELONG TO THE THIOLASE FAMILY. Q7U115 No lipid metabolism Rv0914c NC_002945.3 Mycobrowser_v2 CDS 1020524 1021795 . - 0 Mb0939c PPE14 ppe family protein ppe14 Mb0939c, PPE14, len: 423 aa. Equivalent to Rv0915c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 423 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. Rv1807 from Mycobacterium tuberculosis (403 aa),FASTA scores: opt: 966, E(): 4.4e-30, (45.7% identity in 392 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Q7U114 No NC_002945.3 Mycobrowser_v2 CDS 1022553 1024334 . + 0 Mb0941 betP POSSIBLE GLYCINE BETAINE TRANSPORT INTEGRAL MEMBRANE PROTEIN BETP Mb0941, betP, len: 593 aa. Equivalent to Rv0917,len: 593 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 593 aa overlap). Possible betP, glycine betaine transporter, integral membrane protein, highly similar to many transporters, mainly glycine betaine transporters, e.g. P54582|BETP_CORGL glycine betaine transporter from Corynebacterium glutamicum (Brevibacterium flavum) (595 aa), FASTA scores: opt: 1367,E(): 0, (42.7% identity in 504 aa overlap); T35264 probable BCCT family transporter from Streptomyces coelicolor (578 aa); NP_243511.1|NC_002570 glycine betaine transporter from Bacillus halodurans (504 aa); NP_439848.1|NC_000907 high-affinity choline transport protein (betT) from Haemophilus influenzae (669 aa); etc. SEEMS TO BELONG TO THE BCCT (TC 2.33) FAMILY OF TRANSPORTERS. X2BGK1,P63696 No cell wall and cell processes Rv0917 NC_002945.3 Mycobrowser_v2 CDS 1024677 1025153 . + 0 Mb0942 conserved protein Mb0942, -, len: 158 aa. Equivalent to Rv0918, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 158 aa overlap). Conserved hypothetical protein, similar in part to Q50116 hypothetical protein from Mycobacterium leprae (44 aa), FASTA scores: opt: 132,E(): 0.0055, (65.6% identity in 32 aa overlap). Also some similarity in C-terminus with other hypothetical proteins e.g. NP_289961.1|NC_002655 hypothetical protein from Escherichia coli strain O157:H7 (94 aa); etc. Q7U112 No conserved hypotheticals Rv0918 NC_002945.3 Mycobrowser_v2 CDS 1025150 1025650 . + 0 Mb0943 gcn5-related n-acetyltransferase Mb0943, -, len: 166 aa. Equivalent to Rv0919, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 166 aa overlap). Conserved hypothetical protein, some similarity to Q50115 hypothetical protein from Mycobacterium leprae (90 aa), FASTA scores: opt: 243,E(): 5.3e-11, (56.5% identity in 85 aa overlap). Q7U111 No intermediary metabolism and respiration Rv0919 NC_002945.3 Mycobrowser_v2 tRNA 1025787 1025859 . - 0 argT argT tRNA-Arg argT, len: 73 nt. Equivalent to argT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon cct. No NC_002945.3 Mycobrowser_v2 CDS 1028151 1029803 . + 0 Mb0946 possible transposase Mb0946, -, len: 550 aa. Equivalent to Rv0922, len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 550 aa overlap). Possible transposase for IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa), FASTA scores: opt 939, E(): 0,(40.6% identity in 465 aa overlap); etc. Q7U108 No insertion seqs and phages Rv0922 NC_002945.3 Mycobrowser_v2 CDS 1029979 1031043 . - 0 Mb0947c CONSERVED HYPOTHETICAL PROTEIN Mb0947c, -, len: 354 aa. Equivalent to Rv0923c,len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Conserved hypothetical protein, showing similarity with C-terminal part of AF034138|AF034138_7|yjoB HYPOTHETICAL PROTEIN from Bacillus subtilis (200 aa), FASTA scores: opt: 193, E(): 4.2e-05, (32.3% identity in 167 aa overlap). Q7U107 No conserved hypotheticals Rv0923c NC_002945.3 Mycobrowser_v2 CDS 1031044 1033098 . - 0 Mb0948c mntH conserved protein Mb0948c, mntH, len: 685 aa. Similar to Rv0924c (mntH) and Rv0925c, len: 428 aa and 245 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 428 aa overlap and 93.2% identity in 237 aa overlap). mntH (alternative gene name: Nramp, Mramp), H+-dependent divalent cation-transport integral membrane protein (see citations below), equivalent to O69443|MNTH_MYCBO PROBABLE MANGANESE TRANSPORT PROTEIN MNTH (BRAMP) from Mycobacterium bovis (415 aa); and NP_302396.1|NC_002677 probable manganese transport protein from Mycobacterium leprae (426 aa). Also similar (but longer 51 aa in N-terminus) to AAA63075.1|U15184 SMF2 protein from Mycobacterium leprae (377 aa), FASTA scores: opt: 1780,E(): 0, (74.5% identity in 376 aa overlap). Also similar to many orthologues of the eukaryotic Nramp (natural resistance-associated macrophage protein), also known as mntH, e.g. NP_456951.1|NC_003198 manganese transport protein MntH from Salmonella enterica subsp. enterica serovar Typhi (413 aa); etc. BELONGS TO THE NRAMP FAMILY. And Conserved hypothetical protein, similar to AL132991|SCF55_19 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (197 aa), FASTA scores: opt: 459, E(): 1.2e-23,(39.3% identity in 201 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product. X2BG74,O69443 No NC_002945.3 Mycobrowser_v2 CDS 1033175 1034251 . - 0 Mb0949c CONSERVED HYPOTHETICAL PROTEIN Mb0949c, -, len: 358 aa. Equivalent to Rv0926c,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 358 aa overlap). Conserved hypothetical protein, similar to Rv1059 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (354 aa). Also shows some similarity to AF170923|AF170923_3 dihydrodipicolinate reductase from Mastigocladus laminosus (278 aa), FASTA scores: opt: 170, E(): 0.00088, (25.7% identity in 276 aa overlap). Q7U105 No conserved hypotheticals Rv0926c NC_002945.3 Mycobrowser_v2 CDS 1034305 1035096 . - 0 Mb0950c probable short-chain type dehydrogenase/reductase Mb0950c, -, len: 263 aa. Equivalent to Rv0927c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 263 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, notably 7-alpha-hydroxysteroid dehydrogenases and glucose 1-dehydrogenases e.g. P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 551,E(): 1e-26, (39.5% identity in 248 aa overlap); NP_252778.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa); etc. Also similar to other dehydrogenases from Mycobacterium tuberculosis e.g. MTCY09F9.36, E():1.4e-18; MTCY369.14, E():8e-17; MTCY02B10.14, E():2.5e-14; MTCY09F9.23c, E():1.5e-13; MTCY03C7.07, E():1.9e-13. Contains PS00061 Short-chain dehydrogenases/reductases family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U104 No intermediary metabolism and respiration Rv0927c NC_002945.3 Mycobrowser_v2 CDS 1035368 1036480 . + 0 Mb0951 pstS3 PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS3 (PBP-3) (PSTS3) (PHOS1) Mb0951, pstS3, len: 370 aa. Equivalent to Rv0928,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 370 aa overlap). pstS3 (previously known as phoS2), phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to others from Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1 phosphate-binding protein 3 precursor (328 aa), FASTA scores: opt: 1772, E(): 0,(79.6% identity in 328 aa overlap); and highly similar to others e.g. AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa). Also highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (370 aa); and Rv0934|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (374 aa) from Mycobacterium tuberculosis (Mycobacterium tuberculosis seems to have three PstS-like proteins,others being Rv0932c and Rv0934c). Contains lipoprotein signature (PS00013) at N-terminus. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. X2BGL4,P0A5Y3 No NC_002945.3 Mycobrowser_v2 CDS 1066517 1067884 . + 0 Mb0980 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0980, -, len: 455 aa. Equivalent to Rv0955, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 455 aa overlap). Probable conserved integral membrane protein, highly similar to AL035500|MLCL373_6 putative membrane protein from Mycobacterium leprae (430 aa), FASTA score: (75.9% identity in 419 aa overlap); and AAL05878.1|AF411607_2|AF411607 unknown protein from Mycobacterium avium subsp. paratuberculosis (409 aa). X2BGM3,P64772 No cell wall and cell processes Rv0955 NC_002945.3 Mycobrowser_v2 CDS 1036493 1037467 . + 0 Mb0952 pstC2 PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTC2 Mb0952, pstC2, len: 324 aa. Equivalent to Rv0929,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 324 aa overlap). pstC2,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_302394.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (319 aa); CAB88474.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (336 aa); NP_290359.1| NC_002655 high-affinity phosphate-specific transport system (cytoplasmic membrane component) from Escherichia coli strain O157:H7 (319 aa); etc. Also similar to Rv935|MTCY08D9.04c|PSTC1 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (338 aa). Contains binding-protein-dependent transport systems inner membrane component signature (PS00402). X2BGK2,P0A631 No NC_002945.3 Mycobrowser_v2 CDS 1037464 1038378 . + 0 Mb0953 pstA1 PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA1 Mb0953, pstA1, len: 304 aa. Equivalent to Rv0930,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Probable pstA1,phosphate-transport integral membrane ABC transporter (see citation below), highly similar to others e.g. NP_302393.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (304 aa); CAB88473.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (354 aa) (N-terminus longer); NP_312689.1|NC_002695 phosphate transport system permease protein PstA from Escherichia coli strain O157:H7 (296 aa); etc. Also similar to Rv0936|MTCY08D9.03c|PSTA2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa). Q7U103 No NC_002945.3 Mycobrowser_v2 CDS 1038385 1039494 . - 0 Mb0954c pknDb TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D PKNDb [SECOND PART](PROTEIN KINASE D) (STPK D) Mb0954c, pknDb, len: 369 aa. Equivalent to 3' end of Rv0931c, len: 664 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 369 aa overlap). pknD (alternate gene name: mbk), transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citations below),equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa); and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 aa). Also highly similar to others, particularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa); NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa); etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase subdomain. Contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb. Q7U102 No NC_002945.3 Mycobrowser_v2 CDS 1039505 1040380 . - 0 Mb0955c pknDa TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D PKNDa [FIRST PART] (PROTEIN KINASE D) (STPK D) Mb0955c, pknDa, len: 291 aa. Equivalent to 5' end of Rv0931c, len: 664 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 276 aa overlap). pknD (alternate gene name: mbk), transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citations below),equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa); and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 aa). Also highly similar to others, particularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa); NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa); etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase subdomain. Contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb. Q79IB8 No NC_002945.3 Mycobrowser_v2 CDS 1043766 1044782 . + 0 Mb0960 pstC1 PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTC1 Mb0960, pstC1, len: 338 aa. Equivalent to Rv0935,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 338 aa overlap). pstC1,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_104768.1|NC_002678|pstC phosphate ABC transporter permease protein from Mesorhizobium loti (327 aa); NP_245372.1|NC_002663|PstC PstC protein from Pasteurella multocida (320 aa); P45191|PSTC_HAEIN PHOSPHATE TRANSPORT SYSTEM PERMEASE from Haemophilus influenza (315 aa), FASTA scores: opt: 667, E(): 0, (36.2% identity in 309 aa overlap); etc. Also similar to Rv0929|MTCY21C12.23|PSTC2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (324 aa), FASTA scores: opt: 487, E(): 4.1e-21, (32.3% identity in 303 aa overlap); and shows slight similarity to MTCY08D9.03c|PSTA2|Rv0936 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402). X2BGK3,P0A629 No NC_002945.3 Mycobrowser_v2 CDS 1112835 1113911 . + 0 Mb1023 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb1023, -, len: 358 aa. Equivalent to Rv0996, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 358 aa overlap). Probable conserved transmembrane protein, equivalent to AL035500|MLCL373_25 putative membrane protein from Mycobacterium leprae (342 aa), FASTA scores: (66.4% identity in 360 aa overlap). Contains possible signal sequence and other hydrophobic domains. Q7U0W0 No cell wall and cell processes Rv0996 NC_002945.3 Mycobrowser_v2 CDS 1040402 1041514 . - 0 Mb0956c pstS2 PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS2 (PBP-2) (PSTS2) Mb0956c, pstS2, len: 370 aa. Equivalent to Rv0932c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 370 aa overlap). pstS2,phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa); Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa),FASTA scores: opt: 1601, E(): 0, (64.5% identity in 372 aa overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa) (M. tuberculosis seems to have three PstS-like proteins, others being Rv0928 and Rv0934c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 460, E(): 2.7e-20, (31.2% identity in 375 aa overlap). Contains prokaryotic membrane lipoprotein lipid attachment site (PS00013) at N-terminus so the leader peptide of 22 aa is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. Appears to be co-transcribed with Rv0931c|pknD|mbk. Q7U101 No NC_002945.3 Mycobrowser_v2 CDS 1041730 1041945 . + 0 Mb0957 pstBa PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBa [FIRST PART] Mb0957, pstBa, len: 71 aa. Equivalent to the 5' end of Rv0933, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv (98.4% identity in 64 aa overlap). pstB,phosphate-transport ATP-binding protein ABC transporter (see citations below), thermostable ATPase, highly similar to others e.g. NP_348334.1|NC_003030 ATPase component of ABC-type phosphate transport system from Clostridium acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate ABC transporter ATP-binding protein (pstB) from Borrelia burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC transporter (ATP-binding protein) from Bacillus subtilis (269 aa), FASTA scores: opt: 762, E(): 0, (47.7% identity in 243 aa overlap); etc. Also similar to other M. tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC transporters family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium seem to have no influence on the functionality of this enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pstB into 2 parts, pstBa and pstBb. Q7U100,Q7U0Z9 No NC_002945.3 Mycobrowser_v2 CDS 1041920 1042561 . + 0 Mb0958 pstBb PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBb [SECOND PART] Mb0958, pstBb, len: 213 aa. Equivalent to the 3' end of Rv0933, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 213 aa overlap). pstB, phosphate-transport ATP-binding protein ABC transporter (see citations below), thermostable ATPase, highly similar to others e.g. NP_348334.1|NC_003030 ATPase component of ABC-type phosphate transport system from Clostridium acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate ABC transporter ATP-binding protein (pstB) from Borrelia burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC transporter (ATP-binding protein) from Bacillus subtilis (269 aa),FASTA scores: opt: 762, E(): 0, (47.7% identity in 243 aa overlap); etc. Also similar to other M. tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC transporters family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium seem to have no influence on the functionality of this enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pstB into 2 parts,pstBa and pstBb. X2BG85,Q7U0Z9 No NC_002945.3 Mycobrowser_v2 CDS 1042582 1043706 . + 0 Mb0959 pstS1 PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS1 (PBP-1) (PSTS1) Mb0959, pstS1, len: 374 aa. Equivalent to Rv0934,len: 374 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 374 aa overlap). pstS1 (previously known as phoS1 or phoS), phosphate-binding lipoprotein component of inorganic phosphate transport system (see first, fourth, fifth and sixth citations below), highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA scores: opt: 460, E(): 5.9e-19, (31.2% identity in 375 aa overlap); and Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 435, E():1.1e-17, (30.0% identity in 380 aa overlap) (Mycobacterium tuberculosis seems to have three PstS-like proteins, others being Rv0932c and Rv0928c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 2459, E(): 0, (100% identity in 374 aa overlap). Contains a prokaryotic membrane lipoprotein lipid attachment site (PS00013) at the N-terminus so the 23 aa leader peptide sequence is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. Q7U0Z8 No NC_002945.3 Mycobrowser_v2 CDS 1052011 1052784 . - 0 Mb0966c CONSERVED HYPOTHETICAL PROTEIN Mb0966c, -, len: 257 aa. Equivalent to Rv0941c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Conserved hypothetical protein, showing some similarity with parts of several hypothetical proteins from Streptomyces coelicolor e.g. AL035161|SC9C7_20 (860 aa), FASTA scores: opt: 197, E(): 2.6e-05, (34.2% identity in 114 aa overlap). Q7U0Z5 No conserved hypotheticals Rv0941c NC_002945.3 Mycobrowser_v2 CDS 1044784 1045689 . + 0 Mb0961 pstA2 PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA2 Mb0961, pstA2, len: 301 aa. Equivalent to Rv0936,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). pstA2,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_442269.1|NC_000911|PstA phosphate transport system permease protein from Synechocystis sp. strain PCC 6803 (287 aa); NP_232473.1|NC_002506 phosphate ABC transporter permease protein from Vibrio cholerae (289 aa); P07654|PSTA_ECOLI PHOSPHATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (296 aa), FASTA scores: opt: 464, E(): 6.7e-24, (30.5% identity in 282 aa overlap); etc. Also similar to O86345|MTCY21C12.24|PSTA1|Rv0930 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (304 aa),FASTA scores: opt: 369, E(): 6.1e-15, (32.7% identity in 248 aa overlap). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402). X2BGM5,P0A627 No NC_002945.3 Mycobrowser_v2 CDS 1045666 1046487 . - 0 Mb0962c mku dna end-binding protein, mku Mb0962c, -, len: 273 aa. Equivalent to Rv0937c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Conserved hypothetical protein, highly similar to others e.g. SC6G9.24c|T35620|AL079356 hypothetical protein from Streptomyces coelicolor (365 aa), FASTA scores: opt: 648,E(): 0, (36.5% identity in 274 aa overlap); Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical proteins from Bacillus subtilis (311 aa), FASTA scores: opt: 623, E(): 1.1e-31, (33.9% identity in 274 aa overlap); O28548|AE000984|AF1726|NP_070554.1|NC_000917 conserved hypothetical protein from Archaeoglobus fulgidus (286 aa), FASTA scores: opt: 583, E(): 0, (36.6% identity in 262 aa overlap); etc. Q7U0Z7 No information pathways Rv0937c NC_002945.3 Mycobrowser_v2 CDS 1046603 1048882 . + 0 Mb0963 ligd atp dependent dna ligase ligd (atp dependent polydeoxyribonucleotide synthase) (thermostable dna ligase) (atp dependent polynucleotide ligase) (sealase) (dna repair enzyme) (dna joinase) Mb0963, -, len: 759 aa. Equivalent to Rv0938, len: 759 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 759 aa overlap). Possible ATP-dependent DNA ligase (EC 6.5.1.1), with its C-terminus similar to N-terminal parts of many ATP-dependent DNA ligases e.g. NP_250828.1|NC_002516 probable ATP-dependent DNA ligase from Pseudomonas aeruginosa (840 aa); NP_105436.1|NC_002678 ATP-dependent DNA ligase from Mesorhizobium loti (829 aa); CAB92891.1|AL356932 probable ATP-dependent DNA ligase from Streptomyces coelicolor (326 aa); etc. The N-terminal half shows similarity with hypothetical proteins from Mycobacterium tuberculosis Rv0269c and Rv3730c; and the C-terminal half with the DNA ligases Rv3731 and Rv3062. X2BG90,P59971 No information pathways Rv0938 NC_002945.3 Mycobrowser_v2 CDS 1048879 1050813 . + 0 Mb0964 POSSIBLE BIFUNCTIONAL ENZYME: 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE) + CYCLASE/DEHYDRASE Mb0964, -, len: 644 aa. Equivalent to Rv0939, len: 644 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 644 aa overlap). Possible bifunctional enzyme, including 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase activity (EC 5.3.3.-), and cyclase/dehydrase activity (EC undetermined). N-terminal part similar to many isomerases e.g. NP_343861.1|NC_002754 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Sulfolobus solfataricus (318 aa); NP_068932.1|NC_000917 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Archaeoglobus fulgidus (324 aa),FASTA scores: opt: 400, E(): 5.8e-15, (33.9% identity in 289 aa overlap); etc. And C-terminal part highly similar to many cyclases/dehydrases e.g. AAK61721.1|AY033994 cyclase-like protein from Streptomyces aureofaciens (305 aa); CAC44204.1|AL593842 cyclase from Streptomyces coelicolor (297 aa), FASTA scores: opt: 375, E(): 2.7e-26,(35.6% identity in 284 aa overlap); NP_343860.1|NC_002754 putative Cyclase/dehydrase from Sulfolobus solfataricus (308 aa); etc. Also similar to Rv2993c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. Q7U0Z6 No intermediary metabolism and respiration Rv0939 NC_002945.3 Mycobrowser_v2 tRNA 1113962 1114034 . + 0 alaV alaV tRNA-Ala alaV, len: 73 nt. Equivalent to alaV, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon cgc. No NC_002945.3 Mycobrowser_v2 CDS 1051060 1051926 . - 0 Mb0965c POSSIBLE OXIDOREDUCTASE Mb0965c, -, len: 288 aa. Equivalent to Rv0940c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 288 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); AAG52987.1|AF040570|Rif17 putative alkanal monooxygenase from Amycolatopsis mediterranei (356 aa); etc. Also similar to putative oxidoreductases from Mycobacterium tuberculosis such as Rv0953c|P71557|YT21_MYCTU (282 aa), FASTA scores: opt: 311, E(): 3.7e-08, (31.0% identity in 248 aa overlap),Rv3079c (275 aa), Rv0791c (347 aa), etc. X2BGL1,P64762 No intermediary metabolism and respiration Rv0940c NC_002945.3 Mycobrowser_v2 CDS 1053163 1054203 . - 0 Mb0968c PROBABLE MONOOXYGENASE Mb0968c, -, len: 346 aa. Equivalent to Rv0943c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 346 aa overlap). Possible monooxygenase (EC 1.-.-.-), similar in part to others e.g. NP_250229.1|NC_002516 probable flavin-containing monooxygenase from Pseudomonas aeruginosa (527 aa); AAC36351.1|AF090329 cyclohexanone monooxygenase homolog from Pseudomonas fluorescens (437 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); etc. Also similar to putative monooxygenases from Mycobacterium tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa). FASTA scores: opt: 129, E(): 8.5e-21, (27.5% identity in 236 aa overlap); Rv0892 (495 aa); Rv3049c (524 aa); etc. X2BG95 No intermediary metabolism and respiration Rv0943c NC_002945.3 Mycobrowser_v2 CDS 1054232 1054708 . + 0 Mb0969 POSSIBLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FAPY-DNA GLYCOSYLASE) Mb0969, -, len: 158 aa. Equivalent to Rv0944, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 158 aa overlap). Possible formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), similar to C-terminus of formamidopyrimidine-DNA glycosylases e.g. CAB63194.1|AL133469 putative formamidopyrimidine-DNA glycosylase from Streptomyces coelicolor (287 aa); FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) from Lactococcus lactis subsp. lactis (273 aa), FASTA scores: opt: 246, E(): 2.4e-09,(28.9% identity in 142 aa overlap); O50606|FPG_THETH|MUTM|FPG FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Thermus thermophilus (267 aa); etc. Also similar to C-termini of endonucleases or DNA glycosylases of Mycobacterium tuberculosis e.g. Rv3297, Rv2464c,Rv2924c. MAY BE BELONG TO THE FPG FAMILY. Q7U0Z4 No information pathways Rv0944 NC_002945.3 Mycobrowser_v2 CDS 1054714 1055475 . + 0 Mb0970 probable short-chain type dehydrogenase/reductase Mb0970, -, len: 253 aa. Equivalent to Rv0945, len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 253 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_346338.1|NC_003028 oxidoreductase (short chain dehydrogenase/reductase family) from Streptococcus pneumoniae (253 aa); AAB70845.1|AF019986|PksB from Dictyostelium discoideum (260 aa); AAF86624.1|U87786 clavaldehyde dehydrogenase from Streptomyces clavuligerus (247 aa); P37440|UCPA_ECOLI oxidoreductase from Escherichia coli (285 aa), FASTA scores: opt: 275, E(): 1.1e-12, (33.8% identity in 201 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U0Z3 No intermediary metabolism and respiration Rv0945 NC_002945.3 Mycobrowser_v2 CDS 1068000 1068647 . + 0 Mb0981 purN PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN (GART) (GAR TRANSFORMYLASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE) Mb0981, purN, len: 215 aa. Equivalent to Rv0956,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Probable purN,5'-phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), equivalent to AAF05726.1|AF191543_1|AF191543|PurN phosphoribosylglycinamide formyltransferase from Mycobacterium avium subsp. paratuberculosis (209 aa); and AL035500|MLCL373_7 from Mycobacterium leprae (215 aa),FASTA score: (79.4% identity in 214 aa overlap). Also highly similar to others e.g. BAA89443.1|AB003159 from Corynebacterium ammoniagenes (199 aa); NP_241498.1|NC_002570 from Bacillus halodurans (188 aa); P08179|PUR3_ECOLI|B2500 from Escherichia coli strain K12 (212 aa), FASTA scores: opt: 380, E(): 2.4e-18, (36.6% identity in 183 aa overlap); C-terminus of P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 from Drosophila pseudoobscura (Fruit fly) (1364 aa); etc. Q7U0Y9 No intermediary metabolism and respiration Rv0956 NC_002945.3 Mycobrowser_v2 CDS 1055491 1057152 . - 0 Mb0971c pgi PROBABLE GLUCOSE-6-PHOSPHATE ISOMERASE PGI (GPI) (PHOSPHOGLUCOSE ISOMERASE) (PHOSPHOHEXOSE ISOMERASE) (PHI) Mb0971c, pgi, len: 553 aa. Equivalent to Rv0946c,len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 553 aa overlap). Probable pgi,glucose-6-phosphate isomerase (EC 5.3.1.9), equivalent to NP_301236.1|NC_002677 glucose-6-phosphate isomerase from Mycobacterium leprae (554 aa); and P96803|G6PI_MYCSM GLUCOSE-6-PHOSPHATE ISOMERASE from Mycobacterium smegmatis (442 aa). Also highly similar to others e.g. T36015 glucose-6-phosphate isomerase from Streptomyces coelicolor (551 aa); P11537|G6PI_ECOLI|GPI glucose-6-phosphate isomerase from Escherichia coli strains K12 and O157:H7 (549 aa), FASTA scores: opt: 1779, E(): 0, (51.4% identity in 554 aa overlap); etc. Contains PS00765 Phosphoglucose isomerase signature 1, and PS00174 Phosphoglucose isomerase signature 2. BELONGS TO THE GPI FAMILY. X2BGN2,P64193 No NC_002945.3 Mycobrowser_v2 CDS 1057767 1057997 . - 0 Mb0972c probable mycolyl transferase, pseudogene Mb0972c, -, len: 76 aa. Equivalent to Rv0947c, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 76 aa overlap). Probable mycolyl transferase pseudogene (EC 2.-.-.-), similar to part of P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c) (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 213, E(): 2e-08,(69.6% identity in 46 aa overlap). No lipid metabolism Rv0947c NC_002945.3 Mycobrowser_v2 CDS 1065566 1066477 . + 0 Mb0979 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb0979, -, len: 303 aa. Equivalent to Rv0954, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 303 aa overlap). Probable conserved transmembrane protein, highly similar to 34KD_MYCPA|Q04959 34 kd antigenic protein from Mycobacterium paratuberculosis (298 aa), FASTA scores: opt: 1023, E(): 7.2e-36, (59.3% identity in 305 aa overlap); AAC69251.1|U82111 34 kDa antigen precursor from Mycobacterium leprae (336 aa); and AL035500|MLCL373.06 hypothetical membrane protein from Mycobacterium leprae (297 aa), FASTA score: (55.6% identity in 315 aa overlap). X2BGJ1,P65638 No cell wall and cell processes Rv0954 NC_002945.3 Mycobrowser_v2 CDS 1058727 1061042 . + 0 Mb0974 uvrD1 probable atp-dependent dna helicase ii uvrd1 Mb0974, uvrD1, len: 771 aa. Equivalent to Rv0949,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 771 aa overlap). Probable uvrD1, ATP dependent DNA helicase (EC 3.6.1.-), equivalent to P_301239.1|NC_002677 putative ATP-dependent DNA helicase from Mycobacterium leprae (778 aa). Also highly similar to others e.g. CAB92660.1|AL356832 from Streptomyces coelicolor (831 aa) (N-terminus longer); P56255|PCRA_BACST from Bacillus stearothermophilus (724 aa); Q10213|YAY5_SCHPO from Schizosaccharomyces pombe (Fission yeast) (887 aa), FASTA scores: opt: 927, E(): 0, (33.5% identity in 659 aa overlap); etc. Also similar to several other UvrD-like proteins in Mycobacterium tuberculosis e.g. Rv3201c, Rv3198c, Rv3202c. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. Note that previously known as uvrD. X2BGI2,P0A5A4 No NC_002945.3 Mycobrowser_v2 CDS 1068644 1070215 . + 0 Mb0982 purH PROBABLE BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH: PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE (AICAR TRANSFORMYLASE) (5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE-4-CARBOXAMIDE FORMYLTRANSFERASE) + INOSINEMONOPHOSPHATE CYCLOHYDROLASE (IMP CYCLOHYDROLASE) (INOSINICASE) (IMP SYNTHETASE) (ATIC) Mb0982, purH, len: 523 aa. Equivalent to Rv0957,len: 523 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 523 aa overlap). Probable purH,bifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase (EC 2.1.2.3) and inosine-monophosphate (IMP) cyclohydrolase (EC 3.5.4.10), equivalent to AL035500|MLCL373_8 putative phosphoribosylaminoimidazolecarboxamide formyltransferase from Mycobacterium leprae (527 aa), FASTA score: (88.1% identity in 520 aa overlap); and AF05727.1|AF191543_2|AF191543|PurH from Mycobacterium avium subsp. paratuberculosis (527 aa). Also highly similar to others e.g. CAB92677.1|AL356832 bifunctional purine biosynthesis protein from Streptomyces coelicolor (523 aa); NP_388534.1|NC_000964 phosphoribosylaminoimidazole carboxy formyl formyltransferase + inosine-monophosphate cyclohydrolase from Bacillus subtilis (512 aa); P15639|PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase from Escherichia coli (529 aa), FASTA scores: opt: 1147,E(): 0, (44.8% identity in 533 aa overlap); etc. BELONGS TO THE PURH FAMILY. X2BGN4,P67542 No intermediary metabolism and respiration Rv0957 NC_002945.3 Mycobrowser_v2 CDS 1061123 1062121 . - 0 Mb0975c CONSERVED HYPOTHETICAL PROTEIN Mb0975c, -, len: 332 aa. Equivalent to Rv0950c,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 332 aa overlap). Conserved hypothetical protein, highly similar to AL035500|MLCL373.02c|T45433 hypothetical protein from Mycobacterium leprae (343 aa),FASTA scores: opt: 1500, E(): 0, (71.0% identity in 331 aa overlap). C-terminus highly similar to part of various proteins e.g. C-terminal part of NP_441943.1|NC_000911|NlpD lipoprotein from Synechocystis sp (715 aa); N-terminal part of NP_066789.1|NC_002576 putative peptidase from Rhodococcus equi (546 aa); C-terminal part of NP_212396.1|NC_001318 conserved hypothetical protein from Borrelia burgdorferi (417 aa); C-terminal part of P33648|NLPD_ECOLI|nlpd lipoprotein from Escherichia coli (379 aa), FASTA scores: opt: 276, E(): 2e-10, (29.9% identity in 234 aa overlap); etc. Q7U0Z2 No conserved hypotheticals Rv0950c NC_002945.3 Mycobrowser_v2 CDS 1062431 1063594 . + 0 Mb0976 sucC PROBABLE SUCCINYL-COA SYNTHETASE (BETA CHAIN) SUCC (SCS-BETA) Mb0976, sucC, len: 387 aa. Equivalent to Rv0951,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Probable sucC,succinyl-Coa synthetase, beta chain (EC 6.2.1.5),equivalent to AL035500|MLCL373_3|NP_301241.1|NC_002677 succinyl-CoA synthase [beta] chain from Mycobacterium leprae (393 aa), FASTA score: (86.7% identity in 391 aa overlap). Also highly similar to others e.g. AB92671.1|AL356832 succinyl-CoA synthetase beta chain from Streptomyces coelicolor (394 aa); P25126|SUCC_THEFL SUCCINYL-COA SYNTHETASE BETA CHAIN from Thermus aquaticus (378 aa); P07460|SUCC_ECOLI succinyl-CoA synthetase beta chain from Escherichia coli (388 aa), FASTA scores: opt: 933, E(): 0, (41.0% identity in 390 aa overlap); etc. X2BGN9,Q7U0Z1 No intermediary metabolism and respiration Rv0951 NC_002945.3 Mycobrowser_v2 CDS 1187883 1188449 . + 0 Mb1094 CONSERVED HYPOTHETICAL PROTEIN Mb1094, -, len: 188 aa. Equivalent to Rv1065, len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 188 aa overlap). Conserved hypothetical protein, some similarity to AL0209|SC4H8_11 hypothetical protein from Streptomyces coelicolor (182 aa), FASTA scores: opt: 156, E(): 0.0011, (31.3% identity in 195 aa overlap). Q7U0R3 No conserved hypotheticals Rv1065 NC_002945.3 Mycobrowser_v2 CDS 1063607 1064518 . + 0 Mb0977 sucD PROBABLE SUCCINYL-COA SYNTHETASE (ALPHA CHAIN) SUCD (SCS-ALPHA) Mb0977, sucD, len: 303 aa. Equivalent to Rv0952,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Probable sucD,succinyl-CoA synthetase, alpha chain (EC 6.2.1.5),equivalent to AL035500|MLCL373_4|NP_301242.1|NC_002677 succinyl-CoA synthase [alpha] chain from Mycobacterium leprae (300 aa), FASTA score: (86.3% identity in 300 aa overlap). Also highly similar to others e.g. CAB92672.1|AL356832 from Streptomyces coelicolor (294 aa); P53591|SUCD_COXBU from Escherichia coli (288 aa), FASTA scores: opt: 855, E(): 0, (53.8% identity in 286 aa overlap); etc. Contains PS00399 ATP-citrate lyase and succinyl-CoA ligases active site, and PS00017 ATP/GTP-binding site motif A (P-loop). X2BGN0,Q7U0Z0 No intermediary metabolism and respiration Rv0952 NC_002945.3 Mycobrowser_v2 CDS 1064553 1065401 . - 0 Mb0978c POSSIBLE OXIDOREDUCTASE Mb0978c, -, len: 282 aa. Equivalent to Rv0953c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 282 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to CAA48222.1|X68102 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (166 aa). Similar to several hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); NP_070025.1|NC_000917 N5,N10-methylenetetrahydromethanopterin reductase (mer-2) from Archaeoglobus fulgidus (348 aa); etc. Also similar to several hypothetical proteins and oxidoreductases from Mycobacterium tuberculosis e.g. Rv2161c|O06216|Z95388|MTCY270.07 (288 aa), FASTA scores: opt: 633, E(): 0, (40.4% identity in 277 aa overlap),Rv3079c (275 aa), Rv0791c (347 aa), etc. Contains PS00201 Flavodoxin signature. X2BGA8,P64770 No intermediary metabolism and respiration Rv0953c NC_002945.3 Mycobrowser_v2 CDS 1107894 1108550 . - 0 Mb1017c HYPOTHETICAL PROTEIN Mb1017c, -, len: 218 aa. Equivalent to Rv0990c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Hypothetical unknown protein. Q7U0W6 No conserved hypotheticals Rv0990c NC_002945.3 Mycobrowser_v2 CDS 1070322 1071701 . + 0 Mb0983 POSSIBLE MAGNESIUM CHELATASE Mb0983, -, len: 459 aa. Equivalent to Rv0958, len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 459 aa overlap). Possible magnesium chelatase (EC 4.99.1.-), similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148,E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA MAGNESIUM-CHELATASE SUBUNIT CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase (EC 4.99.1.-) chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) Q7U0Y8 No intermediary metabolism and respiration Rv0958 NC_002945.3 Mycobrowser_v2 CDS 1071694 1073712 . + 0 Mb0984 CONSERVED HYPOTHETICAL PROTEIN Mb0984, -, len: 672 aa. Equivalent to Rv0959, len: 672 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 672 aa overlap). Conserved hypothetical protein, similar to AE002069|AE002069_12 hypothetical protein from Deinococcus radiodurans (403 aa), FASTA scores: opt: 395, E(): 1.3e-15, (26.8% identity in 426 aa overlap). Contains a single copy at the N-terminus of a short repeat found three times in the M. tuberculosis ORF O33341|MTV003.05c|AL008883. X2BGJ9 No conserved hypotheticals Rv0959 NC_002945.3 Mycobrowser_v2 CDS 1073766 1073987 . + 0 Mb0984A vapB9 Possible antitoxin VapB9 Mb0984A, len: 73 aa. Equivalent to Rv0959A len: 73 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB9,antitoxin, part of toxin-antitoxin (TA) operon with Rv0960 (See Arcus et al., 2005; Pandey and Gerdes, 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv1721c X2BGM8 No virulence, detoxification, adaptation Rv0959A NC_002945.3 Mycobrowser_v2 CDS 1073984 1074367 . + 0 Mb0985 vapc9 possible toxin vapc9 Mb0985, -, len: 127 aa. Equivalent to Rv0960, len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 127 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv0065|MTV030.08 (133 aa),FASTA scores: E(): 1.5e-14, (38.3% identity in 128 aa overlap), Rv1720c (129 aa), and Rv0549c (137 aa). X2BGP9,P64774 No virulence, detoxification, adaptation Rv0960 NC_002945.3 Mycobrowser_v2 CDS 1074513 1074860 . + 0 Mb0986 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb0986, -, len: 115 aa. Equivalent to Rv0961, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Probable integral membrane protein. X2BGN7,P64776 No cell wall and cell processes Rv0961 NC_002945.3 Mycobrowser_v2 CDS 1074879 1075553 . - 0 Mb0987c lprP POSSIBLE LIPOPROTEIN LPRP Mb0987c, lprP, len: 224 aa. Equivalent to Rv0962c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Possible lprP,lipoprotein. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. X2BGC0,P59987 No NC_002945.3 Mycobrowser_v2 CDS 1075736 1076536 . - 0 Mb0988c CONSERVED HYPOTHETICAL PROTEIN Mb0988c, -, len: 266 aa. Equivalent to Rv0963c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 266 aa overlap). Conserved hypothetical protein, similar in part to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: E(): 1.2e-23,(39.0% identity in 254 aa overlap); Rv2542 (403 aa); Rv2079 (656 aa). Also similar in part to AL133423|SC4A7_3 HYPOTHETICAL SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FASTA scores: opt: 231, E(): 6.8e-07, (31.4% identity in 204 aa overlap); and SCH10.21c|T36533 hypothetical protein from Streptomyces coelicolor (329 aa). X2BGL0 No conserved hypotheticals Rv0963c NC_002945.3 Mycobrowser_v2 CDS 1077217 1077636 . - 0 Mb0990c CONSERVED HYPOTHETICAL PROTEIN Mb0990c, -, len: 139 aa. Equivalent to Rv0965c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 139 aa overlap). Conserved hypothetical protein, showing weak similarity with Rv2798c|MTCY16B7.45 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (108 aa), FASTA scores: E(): 5.6e-12, (38.9% identity in 90 aa overlap). Equivalent to AAK45242.1 from Mycobacterium tuberculosis strain CDC1551 (146 aa) but shorter 7 aa. Q7U0Y7 No conserved hypotheticals Rv0965c NC_002945.3 Mycobrowser_v2 CDS 1077672 1078274 . - 0 Mb0991c conserved protein Mb0991c, -, len: 200 aa. Equivalent to Rv0966c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 200 aa overlap). Conserved hypothetical protein, equivalent to AL035500|MLCL373_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (200 aa),FASTA scores: opt: 1080, E(): 0, (79.5% identity in 200 aa overlap). Also highly similar to SCE6.30c|CAB88834.1|AL353832 hypothetical protein from Streptomyces coelicolor (277 aa). Some similarity to Rv2862c|MTV007.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (194 aa), FASTA scores: E(): 3.1e-06, (31.5% identity in 184 aa overlap). Equivalent to AAK45243.1 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 30 aa. Note that Rv0966c has been shortened since first entry. Q7U0Y6 No conserved hypotheticals Rv0966c NC_002945.3 Mycobrowser_v2 CDS 1078414 1078773 . + 0 Mb0992 csor copper-sensitive operon repressor csor Mb0992, -, len: 119 aa. Equivalent to Rv0967, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 119 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. AE002074|AE002074_11 from Deinococcus radiodurans (102 aa), FASTA scores: opt: 233, E(): 8.6e-10, (47.0% identity in 83 aa overlap); O32222|Z99121|YVGZ from Bacillus subtilis (101 aa), FASTA scores: opt:228, E(): 3.2e-15, (38.0% identity in 92 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0190, and Rv1766. X2BGF2,Q7U0Y5 No regulatory proteins Rv0967 NC_002945.3 Mycobrowser_v2 CDS 1114312 1114563 . + 0 Mb1023A HYPOTHETICAL PROTEIN Mb1023A, -, len: 83 aa. Equivalent to hypothetical protein MT1025.2 from Mycobacterium tuberculosis strain CDC1551, (100% identity with 83 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al.,2013). Mb1023A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions. X2BGU3 No NC_002945.3 Mycobrowser_v2 CDS 1079182 1081494 . + 0 Mb0994 ctpV PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE CTPV Mb0994, ctpV, len: 770 aa. Equivalent to Rv0969,len: 770 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 770 aa overlap). Probable ctpV, metal cation transporter P-type ATPase (transmembrane protein) (EC 3.6.3.-), highly similar (except in N-terminus) to others e.g. NP_391230.1|NC_000964 similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); P37279|ATCS_SYNP7|PACS cation-transporting ATPase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (747 aa), FASTA scores: opt: 1851, E(): 0, (52.1% identity in 664 aa overlap); etc. Equivalent to AAK45246.1 from Mycobacterium tuberculosis strain CDC1551 (792 aa) but shorter 22 aa. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). Q7U0Y4 No cell wall and cell processes Rv0969 NC_002945.3 Mycobrowser_v2 CDS 1081491 1082123 . + 0 Mb0995 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Mb0995, -, len: 210 aa. Equivalent to Rv0970, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Probable conserved integral membrane protein, equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). X2BGU9,P64782 No cell wall and cell processes Rv0970 NC_002945.3 Mycobrowser_v2 CDS 1082214 1083023 . - 0 Mb0996c echA7 PROBABLE ENOYL-COA HYDRATASE ECHA7 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb0996c, echA7, len: 269 aa. Equivalent to Rv0971c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 269 aa overlap). Probable echA7,enoyl-CoA hydratase (EC 4.2.1.17), similar to many e.g. CAB95895.1|AL359988 putative enoyl CoA hydratase from Streptomyces coelicolor (247 aa); P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (257 aa),FASTA scores: opt: 369, E(): 2.6e-15, (33.7% identity in 246 aa overlap); etc. Q7U0Y3 No NC_002945.3 Mycobrowser_v2 CDS 1083023 1084189 . - 0 Mb0997c fadE12 acyl-coa dehydrogenase fade12 Mb0997c, fadE12, len: 388 aa. Equivalent to Rv0972c, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 388 aa overlap). Probable fadE12, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB95893.1|AL359988 putative acyl CoA dehydrogenase from Streptomyces coelicolor (382 aa); P45857|ACDB_BACSU from Bacillus subtilis (379 aa), FASTA scores: opt: 576, E(): 2.3e-26, (29.7% identity in 381 aa overlap); etc. X2BGF7,Q7U0Y2 No lipid metabolism Rv0972c NC_002945.3 Mycobrowser_v2 CDS 1084186 1086189 . - 0 Mb0998c accA2 PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) ACCA2: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP) Mb0998c, accA2, len: 667 aa. Equivalent to Rv0973c,len: 667 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 667 aa overlap). Probable accA2 (alternate gene name: bccA), acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)],highly similar to others e.g. CAB95892.1|AL359988 putative acetyl/propionyl CoA carboxylase alpha subunit from Streptomyces coelicolor (614 aa); NP_250702.1|NC_002516 probable acyl-CoA carboxylase alpha chain from Pseudomonas aeruginosa (655 aa); NP_420971.1|NC_002696 acetyl/propionyl-CoA carboxylase alpha subunit from Caulobacter crescentus ( 654 aa); NP_251581.1|NC_002516 probable biotin carboxylase/biotin carboxyl carrier protein from Pseudomonas aeruginosa (661 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) (654 aa), FASTA scores, opt: 250, E(): 4e-09, (28.6% identity in 182 aa overlap); and Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127 aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in 500 aa overlap). Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site. Q7U0Y1 No NC_002945.3 Mycobrowser_v2 CDS 1086195 1087784 . - 0 Mb0999c accD2 PROBABLE ACETYL-/PROPIONYL-COA CARBOXYLASE (BETA SUBUNIT) ACCD2 Mb0999c, accD2, len: 529 aa. Equivalent to Rv0974c,len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 529 aa overlap). Probable accD2,acetyl-/propionyl-CoA carboxylase (beta subunit) (EC 6.4.1.-), highly similar to many e.g. CAB95891.1|AL35998 putative acetyl/propionyl CoA carboxylase beta subunit from Streptomyces coelicolor (532 aa); NP_250704.1|NC_002516 probable acyl-CoA carboxyltransferase beta chain from Pseudomonas aeruginosa (535 aa); BAB16296.1|AB039884 acetyl-CoA carboxylase carboxyltransferase from Myxococcus xanthus (538 aa); NP_420973.1|NC_002696 putative propionyl-CoA carboxylase beta subunit from Caulobacter crescentus (530 aa); etc. Also similar to other from Mycobacterium tuberculosis: Rv2502c|ACCD1, Rv3799c|ACCD4, etc. COULD BELONG TO THE ACCD/PCCB FAMILY. Q7U0Y0 No NC_002945.3 Mycobrowser_v2 CDS 1087825 1088934 . - 0 Mb1000c fadE13 PROBABLE ACYL-COA DEHYDROGENASE FADE13 Mb1000c, fadE13, len: 369 aa. Equivalent to the 5' end of Rv0975c, len: 382 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 349 aa overlap). Probable fadE13, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. T35427 probable acyl-CoA dehydrogenase from Streptomyces coelicolor (382 aa); M74096|HUMACADL_1 Human long chain acyl-CoA dehydrogenase from Homo sapiens (430 aa), FASTA scores: opt: 819, E(): 0, (37.0% identity in 376 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa), FASTA scores: (40.3% identity in 375 aa overlap). Contains PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U0X9 No NC_002945.3 Mycobrowser_v2 CDS 1088931 1090613 . - 0 Mb1001c CONSERVED HYPOTHETICAL PROTEIN Mb1001c, -, len: 560 aa. Equivalent to Rv0976c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 560 aa overlap). Conserved hypothetical protein, highly similar to others e.g. CAB95890.1|AL359988 conserved hypothetical protein from Streptomyces coelicolor (558 aa); P_251576.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (600 aa); etc. N-terminal part highly similar to AL035500|MLCL373_14 probable pseudogene from Mycobacterium leprae (163 aa),FASTA score: (50.0% identity in 122 aa overlap). Q7TVC1 No conserved hypotheticals Rv0976c NC_002945.3 Mycobrowser_v2 CDS 1216898 1217002 . + 0 Mb1119 celA2a PROBABLE CELLULASE CELA2A (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE) Mb1119, celA2a, len: 34 aa. Equivalent to Rv1089A,len: 34 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 34 aa overlap). Probable celA2a, first part of cellulase (endoglucanase) (EC 3.2.1.4), similar to N-terminus of others. Q7U0P3 No NC_002945.3 Mycobrowser_v2 CDS 1097273 1097959 . + 0 Mb1007 mprA Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) Mb1007, len: 228 aa. Equivalent to Rv0981 len: 228 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 228 aa overlap). MprA,mycobacterial persistence regulator, a two-component response regulator whose expression is required for entrance into and maintenance of persistent infection (see citation below),equivalent to NP_301250.1|NC_002677 putative two-component response regulator from Mycobacterium leprae (228 aa); and highly similar to others from Mycobacterium leprae. Also highly similar to others e.g. AAG36759.1|AF119221_1|AF119221 response regulator from Corynebacterium glutamicum (232 aa); CAB88489.1|AL353816 putative two-component system response regulator from Streptomyces coelicolor (248 aa); BJY09666_1 two-component response regulator (ragA, ragB and rpoH3) from B.japonicum (226 aa), FASTA score: (43.8% identity in 224 aa overlap); BSAJ2571_44 two-component response regulator from Bacillus subtilis (228 aa), FASTA score: (46.4% identity in 224 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv1033c (257 aa); Rv0903c (236 aa), FASTA score: (50.7 identity in 225 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2. Start changed since first submission (-2 aa). MprAB is involved in the regulation of genes in response to environmental stress (See He et al., 2006). X2BGG7,Q7U0X4 No regulatory proteins Rv0981 NC_002945.3 Mycobrowser_v2 CDS 1090812 1093583 . + 0 Mb1002 PE_PGRS16 pe-pgrs family protein pe_pgrs16 Mb1002, PE_PGRS16, len: 923 aa. Equivalent to Rv0977, len: 923 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 923 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to other PGRS-type sequences e.g. AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa), FASTA score: (45.4% identity in 959 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FASTA score: (51.5% identity in 750 aa overlap); etc. Q7U0X8 No NC_002945.3 Mycobrowser_v2 CDS 1093800 1094807 . - 0 Mb1003c PE_PGRS17 pe-pgrs family protein pe_pgrs17 Mb1003c, PE_PGRS17, len: 335 aa. Similar to Rv0978c, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv, (93.7% identity in 335 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (73.6% identity in 277 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 115 bp to 127 bp substitution leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331 aa). Q7U0X7 No NC_002945.3 Mycobrowser_v2 CDS 1095121 1095315 . - 0 Mb1004c HYPOTHETICAL PROTEIN Mb1004c, -, len: 64 aa. Equivalent to Rv0979c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 64 aa overlap). Hypothetical unknown protein. Start codon changed since first submission (-44 aa) Q7U0X6 No conserved hypotheticals Rv0979c NC_002945.3 Mycobrowser_v2 CDS 1095337 1095510 . + 0 Mb1005 rpmF 50s ribosomal protein l32 rpmf Mb1005, rpmF, len: 57 aa. Equivalent to Rv0979A,len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 57 aa overlap). Probable rpmF, 50S ribosomal protein L32, similar to others e.g. rpmF|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN from Streptomyces coelicolor (56 aa), FASTA scores: E(): 5.1e-09, (63.45% identity in 52 aa overlap); etc. BELONGS TO THE L32P FAMILY OF RIBOSOMAL PROTEINS. X2BGV8,P0A5V9 No information pathways Rv0979A NC_002945.3 Mycobrowser_v2 CDS 1095529 1096902 . - 0 Mb1006c PE_PGRS18 pe-pgrs family protein pe_pgrs18 Mb1006c, PE_PGRS18, len: 457 aa. Equivalent to Rv0980c, len: 457 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 457 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (66.7% identity in 405 aa overlap); Z95844|MTCY493_2 from Mycobacterium tuberculosis (741 aa),FASTA score: (53.0% identity in 394 aa overlap); etc. Q7U0X5 No NC_002945.3 Mycobrowser_v2 CDS 1114744 1115175 . + 0 Mb1024 HYPOTHETICAL PROTEIN Mb1024, -, len: 143 aa. Equivalent to Rv0997, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 143 aa overlap). Hypothetical unknown protein, equivalent to AAK45276.1 from Mycobacterium tuberculosis strain CDC1551 (87 aa) but longer 56 aa. Q7U0V9 No conserved hypotheticals Rv0997 NC_002945.3 Mycobrowser_v2 CDS 1097959 1099473 . + 0 Mb1008 mprB two component sensor kinase mprb Mb1008, mprB, len: 504 aa. Equivalent to Rv0982,len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 504 aa overlap). Probable mprB, two component sensor kinase, transmembrane protein (EC 2.7.3.-) (see citation below), equivalent to AL035500|MLCL373_16|NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa), FASTA score: (81.0% identity in 521 aa overlap). Also highly similar to others (especially in C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221 sensor kinase from Corynebacterium glutamicum (455 aa); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (481 aa); X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa),FASTA scores: opt: 451, E(): 4.2e-21, (36.0% identity in 303 aa overlap); P30847|BAES_ECOLI SENSOR PROTEIN (EC 2.7.3.-) from Escherichia coli (467 aa), FASTA scores: opt: 412, E(): 1.3e-18, (30.4% identity in 336 aa overlap); etc. Also similar in C-terminal region to C-terminus of Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4 identity in 462 aa overlap). X2BGP2,Q7U0X3 No regulatory proteins Rv0982 NC_002945.3 Mycobrowser_v2 CDS 1099517 1100911 . + 0 Mb1009 pepd probable serine protease pepd (serine proteinase) (mtb32b) Mb1009, -, len: 464 aa. Equivalent to Rv0983, len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 464 aa overlap). Probable secreted or membrane serine protease (EC 3.4.21.-), equivalent (but longer 18 aa in N-terminus) to AL035500|MLCL373_17|T45448 probable serine proteinase (EC 3.4.21.-) from Mycobacterium leprae (452 aa), FASTA score: (74.2% identity in 466 aa overlap); and highly similar to others from Mycobacterium leprae. Also highly similar (except in N-terminus) to other proteases e.g. CAC01350.1|AL390975 putative protease from Streptomyces coelicolor (542 aa); NP_440705.1|NC_000911|HtrA serine protease from Synechocystis sp. (452 aa); NP_346646.1|NC_003028 serine protease from Streptococcus pneumoniae (393 aa); etc. Also similar in part to members of the htrA-antigen family e.g. U87242|MTU87242_3|HtrA serine protease from M. tuberculosis (542 aa), FASTA scores: opt: 846, E(): 2e-28,(40.6% identity in 392 aa overlap); and similar to other hypothetical serine proteases e.g. Rv0983, Rv0125, etc. Q7U0X2 No intermediary metabolism and respiration Rv0983 NC_002945.3 Mycobrowser_v2 CDS 1100911 1101456 . + 0 Mb1010 moaB2 POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB2 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD) Mb1010, moaB2, len: 181 aa. Equivalent to Rv0984,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 181 aa overlap). Possible moaB2,pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),highly similar to NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa), FASTA score: (92.3% identity in 181 aa overlap). Also similar to others e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); Q56208|MOCB_SYNP7 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN CB from Synechococcus sp. (319 aa), FASTA score: (37.3% identity in 142 aa overlap); C-terminus of NP_197599.1|NC_003076 MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN from Arabidopsis thaliana (670 aa); etc. Also similar to Rv0865|MOG from Mycobacterium tuberculosis (160 aa); and other mog proteins e.g. CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa). COULD BELONG TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Alternative start codon has been suggested in position 1100508. Q7TTP6 No NC_002945.3 Mycobrowser_v2 CDS 1101476 1101931 . - 0 Mb1011c mscL POSSIBLE LARGE-CONDUCTANCE ION MECHANOSENSITIVE CHANNEL MSCL Mb1011c, mscL, len: 151 aa. Equivalent to Rv0985c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 151 aa overlap). Possible mscL, large conductance mechanosensitive ion channel (integral membrane protein), equivalent to AL035500|MLCL373_19|NP_301254.1|NC_002677 putative mechanosensitive channel protein from Mycobacterium leprae (154 aa), FASTA score: (71.0% identity in 155 aa overlap). Also highly similar to others e.g. NP_268999.1|NC_002737 putative large conductance mechanosensitive channel from Streptococcus pyogenes (120 aa); CAB90974.1|AL355832 putative mechanosensitive channel from Streptomyces coelicolor (156 aa); Q9X722|MSCL_CLOHI LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL from Clostridium histolyticum (133 aa); Z83337|BSZ83337_6 large conductance mechanosensitive channel from Bacillus subtilis (130 aa),FASTA scores: opt: 248, E(): 8.4e-10, (39.0% identity in 136 aa overlap); U08371|ECU08371_1 large conductance mechanosensitive channel from Escherichia coli strain K-12 (136 aa), FASTA score: (36.6% identity in 134 aa overlap); etc. BELONGS TO THE MSCL FAMILY. X2BGR4,P0A5K9 No NC_002945.3 Mycobrowser_v2 CDS 2063545 2064288 . + 0 Mb1859 conserved protein Mb1859, -, len: 247 aa. Equivalent to Rv1828, len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Conserved hypothetical protein, equivalent to O32918|MLCB1788.35c|AL008609 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1397,E(): 0, (87.6% identity in 251 aa overlap). X2BJ64,P67670 No conserved hypotheticals Rv1828 NC_002945.3 Mycobrowser_v2 CDS 1112063 1112674 . + 0 Mb1022 rimJ ribosomal-protein-alanine acetyltransferase rimj (acetylating enzyme for n-terminal of ribosomal protein s5) Mb1022, rimJ, len: 203 aa. Equivalent to Rv0995,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 203 aa overlap). Possible rimJ,ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), equivalent to AL035500|MLCL373_24 probable acyltransferase from Mycobacterium leprae (218 aa), FASTA scores: (86.0% identity in 200 aa overlap). Also similar to others and many acyltransferases e.g. BAB69252.1|AB070946 possible acyltransferase from Streptomyces avermitilis (156 aa); NP_385025.1|NC_003047 PROBABLE RIBOSOMAL-PROTEIN-ALANINE ACETYLTRANSFERASE from Sinorhizobium meliloti (203 aa); P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444 ribosomal-protein-alanine acetyltransferase from Escherichia coli strains K12 and O157:H7 (194 aa), FASTA scores: opt: 247, E(): 1.5e-10, (26.9% identity in 186 aa overlap). SEEMS TO BELONG TO THE ACETYLTRANSFERASE FAMILY,RIMJ SUBFAMILY. Q7U0W1 No information pathways Rv0995 NC_002945.3 Mycobrowser_v2 CDS 1109029 1109622 . - 0 Mb1019c CONSERVED HYPOTHETICAL PROTEIN Mb1019c, -, len: 197 aa. Equivalent to Rv0992c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Conserved hypothetical protein, equivalent to NP_301256.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (197 aa). Also similar, except in N-terminus, to other hypothetical proteins and ligases e.g. SCE87.34|CAB59679.1|AL132674 hypothetical protein from Streptomyces coelicolor (204 aa); NP_461977.1|NC_003197 putative ligase from Salmonella typhimurium (182 aa); P09160|YGFA_ECOLI HYPOTHETICAL 21.1 kDa PROTEIN from Escherichia coli (182 aa), FASTA scores: opt: 191, E(): 1.1e-09, (29.5% identity in 146 aa overlap); etc. Q7U0W4 No conserved hypotheticals Rv0992c NC_002945.3 Mycobrowser_v2 CDS 1102254 1103000 . + 0 Mb1012 PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER Mb1012, -, len: 248 aa. Equivalent to Rv0986, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 248 aa overlap). Probable ATP-binding protein ABC transporter supposed involved in transport of adhesion component (see citation below), highly similar to many ATP-binding proteins e.g. AE0010|AE001033_8 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 669, E(): 0, (45.7% identity in 219 aa overlap); CAB81857.1|AL161691 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa); X84019|ZMDNAGRP_4 glutamate uptake regulatory protein (grp) from Z.mobilis (232 aa), FASTA score: (44.4% identity in 225 aa overlap); Z99111|BSUB0008_108 from Bacillus subtilis (230 aa), FASTA score: (38.7% identity in 222 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7U0X1 No cell wall and cell processes Rv0986 NC_002945.3 Mycobrowser_v2 CDS 1102993 1104264 . + 0 Mb1013 PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb1013, -, len: 423 aa. Equivalent to 5' end of Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 423 aa overlap). Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below),whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265,E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Q7U0X0 No NC_002945.3 Mycobrowser_v2 CDS 1121340 1122599 . - 0 Mb1031c PROBABLE MEMBRANE PROTEIN Mb1031c, -, len: 419 aa. Equivalent to Rv1004c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 419 aa overlap). Probable membrane protein. Contains repetitive sequences, which have similarities with elastin, and possible N-terminal signal sequence. Q7U0V4 No cell wall and cell processes Rv1004c NC_002945.3 Mycobrowser_v2 CDS 1104265 1105560 . + 0 Mb1014 PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER Mb1014, -, len: 431 aa. Equivalent to 3' end of Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 431 aa overlap). Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below),whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265,E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 into two parts, Mb1013 and Mb1014. Q7U0W9 No NC_002945.3 Mycobrowser_v2 CDS 1124165 1125868 . + 0 Mb1033 unknown protein Mb1033, -, len: 567 aa. Equivalent to Rv1006, len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 567 aa overlap). Hypothetical unknown protein. Q7U0V3 No conserved hypotheticals Rv1006 NC_002945.3 Mycobrowser_v2 CDS 1105567 1106727 . + 0 Mb1015 POSSIBLE CONSERVED EXPORTED PROTEIN Mb1015, -, len: 386 aa. Equivalent to Rv0988, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 386 aa overlap). Possible conserved exported protein, with potential N-terminal signal sequence, similar (except in N-terminus) to O32737|L63540 ATTH PROTEIN from Agrobacterium tumefaciens (355 aa),FASTA scores: opt: 651, E(): 5.7e-33, (33.4% identity in 344 aa overlap); and NP_231265.1|NC_002505 conserved hypothetical protein from Vibrio cholerae (372 aa). Q7U0W8 No cell wall and cell processes Rv0988 NC_002945.3 Mycobrowser_v2 CDS 1106856 1107833 . - 0 Mb1016c grcC2 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) Mb1016c, grcC2, len: 325 aa. Equivalent to Rv0989c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). Probable grcC2,polyprenyl diphosphate synthetase (EC 2.5.1.-), highly similar to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to heptaprenyl diphosphate synthase component II (menaquinone biosynthesis) from Listeria innocua (321 aa); NP_371994.1|NC_002758 heptaprenyl diphosphate syntase component II from Staphylococcus aureus subsp. aureus Mu50 (319 aa); P55785|HEP2_BACST heptaprenyl diphosphate synthase component from Bacillus subtilis (323 aa), FASTA scores: opt: 496, E(): 1.4e-24, (31.4% identity in 306 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins e.g. Rv0562|grcC1|NP_215076.1|MTCY25D10.41 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (335 aa); Rv3383, Rv3398c,Rv2173, etc. SEEMS TO BELONG TO THE FPP/GGPP SYNTHETASES FAMILY. Q7U0W7 No NC_002945.3 Mycobrowser_v2 CDS 1109723 1110643 . + 0 Mb1020 galU utp--glucose-1-phosphate uridylyltransferase galu (udp-glucose pyrophosphorylase) (udpgp) (alpha-d-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase) Mb1020, galU, len: 306 aa. Equivalent to Rv0993,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 306 aa overlap). Probable galU,UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9),equivalent to AL035500|MLCL373_22 putative UTP-glucose-1-phosphate uridylyltransferase from Mycobacterium leprae (306 aa), FASTA score: (89.7% identity in 302 aa overlap). Also highly similar to others e.g. AB59678.1|AL132674 UTP-glucose-1-phosphate uridylyltransferase from Streptomyces coelicolor (303 aa); NP_244519.1|NC_002570 UTP-glucose-1-phosphate uridylyltransferase from Bacillus halodurans (297 aa); P25520|GALU_ECOLI|B1236|Z2012|ECS17 UTP--glucose-1-phosphate uridylyltransferase from Escherichia coli strains K12 and O157:H7 (301 aa), FASTA scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa overlap); etc. BELONGS TO THE PROKARYOTIC UDPGP FAMILY. Q7U0W3 No intermediary metabolism and respiration Rv0993 NC_002945.3 Mycobrowser_v2 CDS 1110720 1112000 . + 0 Mb1021 moeA1 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA1 Mb1021, moeA1, len: 426 aa. Equivalent to Rv0994,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 426 aa overlap). Probable moeA1,molybdenum cofactor biosynthesis protein, equivalent to AL035500|MLCL373_23 putative molybdopterin biosynthesis protein from Mycobacterium leprae (424 aa), FASTA score: (88.3% identity in 426 aa overlap). Also highly similar to many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis protein from Streptomyces coelicolor (424 aa); NP_385769.1|NC_003047 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Sinorhizobium meliloti (406 aa); P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein from Escherichia coli (411 aa), FASTA scores: opt: 519,E(): 1.3e-24, (32.3% identity in 402 aa overlap); etc. Also similar to MOEA2|Rv0438c|MTV037.02c PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (405 aa). Note that previously known as moeA. Q7U0W2 No NC_002945.3 Mycobrowser_v2 CDS 1165539 1165946 . - 0 Mb1071c probable is like-2 transposase Mb1071c, -, len: 135 aa. Equivalent to Rv1042c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 135 aa overlap). Probable IS like-2 transposase, similar to Q50761 TRANSPOSASE from Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1149. Q7U0T3 No insertion seqs and phages Rv1042c NC_002945.3 Mycobrowser_v2 CDS 1147466 1148425 . + 0 Mb1054 conserved protein Mb1054, -, len: 319 aa. Equivalent to Rv1026, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 319 aa overlap). Conserved hypothetical protein. Equivalent to AL023514|MLCB4.02 hypothetical protein from Mycobacterium leprae (317 aa) (77.9% identity in 321 aa overlap). Similar to GPPA_ECOLI|P25552 guanosine-5'-triphosphate, 3'-diphosphate pyrophoshatase from Escherichia coli (494 aa), FASTA scores: opt: 281,E(): 3.2e-11, (30.6% identity in 291 aa overlap). Q7U0U3 No virulence, detoxification, adaptation Rv1026 NC_002945.3 Mycobrowser_v2 CDS 1115199 1116200 . + 0 Mb1025 CONSERVED HYPOTHETICAL PROTEIN Mb1025, -, len: 333 aa. Equivalent to Rv0998, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 333 aa overlap). Conserved hypothetical protein, possibly cyclic nucleotide-dependent protein kinase (EC 2.7.-.-), highly similar to NP_301261.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (353 aa); and AL035500|MLCL373.38|T45457 hypothetical protein from Mycobacterium leprae (143 aa), FASTA score: (61.5% identity in 143 aa overlap). Also similar to many hypothetical proteins and cyclic-NMP-dependent protein kinases (generally at C-terminus) e.g. N-terminus of SC9B10.09|T35878 hypothetical protein from Streptomyces coelicolor (1039 aa); P05987|KAPR_DICDI CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN (EC 2.7.1.37) from Dictyostelium discoideum (327 aa), FASTA scores: opt: 177,E(): 0.00036, (32.0% identity in 122 aa overlap); NP_104403.1|NC_002678 hypothetical protein (contains similarity to cAMP-dependent protein kinase regulatory subunit) from Mesorhizobium loti (151 aa); etc. Contains PS00889 Cyclic nucleotide-binding domain signature 2. Q7U0V8 No conserved hypotheticals Rv0998 NC_002945.3 Mycobrowser_v2 CDS 1116218 1116976 . + 0 Mb1026 unknown protein Mb1026, -, len: 252 aa. Equivalent to Rv0999, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 252 aa overlap). Hypothetical unknown protein. Q7U0V7 No conserved hypotheticals Rv0999 NC_002945.3 Mycobrowser_v2 CDS 1279265 1279672 . + 0 Mb1180 POSSIBLE TRANSPOSASE Mb1180, -, len: 135 aa. Equivalent to Rv1149, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 135 aa overlap). Possible transposase. Identical to 117 aa N-terminal region of S21394|X65618 transposase of Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1042c|MTCY10G2.07. TBparse score is 0.926. Q7U0J2 No insertion seqs and phages Rv1149 NC_002945.3 Mycobrowser_v2 CDS 1116982 1117599 . - 0 Mb1027c CONSERVED HYPOTHETICAL PROTEIN Mb1027c, -, len: 205 aa. Equivalent to Rv1000c,len: 205 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 205 aa overlap). Conserved hypothetical protein, equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from Streptomyces coelicolor (210 aa), FASTA scores: E(): 2.1e-45, (56.8% identity); 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein described as DNA repair system specific for alkylated DNA from Xylella fastidiosa (200 aa), FASTA scores: E(): 3.4e-14, (38.55% identity); and similar in C-terminus to other hypothetical proteins. Note that replaces original Rv1000 predicted on other strand. Q7U0V6 No conserved hypotheticals Rv1000c NC_002945.3 Mycobrowser_v2 CDS 1117636 1118844 . + 0 Mb1028 arcA PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD) (ARGININE DIHYDROLASE) Mb1028, arcA, len: 402 aa. Equivalent to Rv1001,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 402 aa overlap). Probable arcA, arginine deiminase (EC 3.5.3.6), similar to e.g. ARCA_PSEAE|P13981 arginine deiminase (417 aa), fasta scores: opt: 581, E(): 1.4e-31, (39.4% identity in 411 aa overlap); also similar to SAGP_STRPY|P16962 streptococcal acid glycoprotein (410 aa), FASTA scores, opt: 823, E():0, (38.3% identity in 402 aa overlap). BELONGS TO THE ARGININE DEIMINASE FAMILY. X2BGU7,P63552 No intermediary metabolism and respiration Rv1001 NC_002945.3 Mycobrowser_v2 CDS 1168121 1169002 . + 0 Mb1074 HYPOTHETICAL PROTEIN Mb1074, -, len: 293 aa. Equivalent to Rv1045, len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 293 aa overlap). Hypothetical unknown protein. Q7U0T0 No conserved hypotheticals Rv1045 NC_002945.3 Mycobrowser_v2 CDS 1118879 1120390 . - 0 Mb1029c CONSERVED MEMBRANE PROTEIN Mb1029c, -, len: 503 aa. Equivalent to Rv1002c,len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 503 aa overlap). Conserved membrane protein. Similar to AL132674|SCE87.05 hypothetical protein from Streptomyces coelicolor (591 aa), FASTA scores: opt: 666, E(): 0, (39.0% identity in 546 aa overlap); weakly similar to TSCC_PSEAM|P55019 thiazide-sensitive sodium-chloride cotransporter from Pseudopleuronectes americanus (1023 aa), FASTA scores: opt: 44, E(): 4.2e-06,(22.4% identity in 326 aa overlap). Q7U0V5 No cell wall and cell processes Rv1002c NC_002945.3 Mycobrowser_v2 CDS 1120473 1121330 . + 0 Mb1030 conserved protein Mb1030, -, len: 285 aa. Equivalent to Rv1003, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 285 aa overlap). Conserved hypothetical protein, similar to others e.g. AL132674|SCE87.04 Streptomyces coelicolor (286 aa), FASTA scores: opt: 877,E(): 0, (53.2% identity in 280 aa overlap); and YRAL_ECOLI|P45528 hypothetical 31.3 kd protein (286 aa),FASTA scores: opt: 561, E(): 4.4e-27, (36.9% identity in 279 aa overlap). X2BGS7,P0A641 No conserved hypotheticals Rv1003 NC_002945.3 Mycobrowser_v2 CDS 1122673 1124109 . - 0 Mb1032c pabB Probable para-aminobenzoate synthase component I PABD Mb1032c, pabB, len: 478 aa. Similar to Rv1005c,len: 458 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 457 aa overlap). Probable PabD,para-aminobenzoate synthase component I (EC 4.1.3.-). Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase component I from Escherichia coli (453 aa), FASTA scores: opt: 589, E(): 1.8e-27, (40.7% identity in 268 aa overlap). Similar to Mycobacterium tuberculosis Rv1609,Rv3215, Rv2386c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (g-a) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (478 aa versus 458 aa). Q7VF03 No NC_002945.3 Mycobrowser_v2 CDS 1169084 1169677 . - 0 Mb1075c HYPOTHETICAL PROTEIN Mb1075c, -, len: 197 aa. Equivalent to Rv1046c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 174 aa overlap). Hypothetical unknown protein. Start changed since first submission (-65 aa). Q7U0S9 No unknown Rv1046c NC_002945.3 Mycobrowser_v2 CDS 1125895 1127454 . - 0 Mb1034c metS methionyl-trna synthetase mets (metrs) (methionine--trna ligase) Mb1034c, metS, len: 519 aa. Equivalent to Rv1007c,len: 519 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 519 aa overlap). Probable metS (MetG),methionyl-tRNA synthetase (EC 6.1.1.10), similar to many e.g. SYM_BACSU|P37465 methionyl-tRNA synthetase from Bacillus subtilus (664 aa), FASTA scores: opt: 1506, E(): 0, (44.9% identity in 492 aa overlap); similar to other M. tuberculosis tRNA synthases e.g. Rv2448c, Rv1536, Rv0041. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. STRONG, TO CYSTEINYL-TRNA SYNTHETASE. X2BGZ0,P59952 No NC_002945.3 Mycobrowser_v2 CDS 1127540 1128334 . + 0 Mb1035 tatD Probable deoxyribonuclease TatD (YjjV protein) Mb1035, tatD, len: 264 aa. Equivalent to Rv1008,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable tatD (alternate gene name: yjjV), deoxyribonuclease (EC 3.1.21.-), component of twin arginine translocation protein export system (see citation below for more information). Similar to many members of the YBL055C/YJJV family e.g. YCFH_ECOLI|P37346 Putative deoxyribonuclease ycfH (EC 3.1.21.-) (265 aa), fasta scores: opt: 487, E(): 1.4e-24, (36.7% identity in 270 aa overlap). Also similar to P37545|YABD_BACSU Putative deoxyribonuclease yabD (255 aa), FASTA scores: opt: 599, E(): 7.7e-33, (40.1% identity in 262 aa overlap). Contains PS01137 Hypothetical YBL055c/yjjV family signature 1, and PS01091 Hypothetical YBL055c/yjjV family signature 3. Q7VF02 No cell wall and cell processes Rv1008 NC_002945.3 Mycobrowser_v2 CDS 1128542 1129630 . + 0 Mb1036 rpfB Probable resuscitation-promoting factor rpfB Mb1036, rpfB, len: 362 aa. Equivalent to Rv1009,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 362 aa overlap). Probable rpfB,resuscitation-promoting factor (see citation below),similar to others from Mycobacterium tuberculosis: Rv2450c|MTV008.06c|RPFE PROBABLE RESUSCITATION-PROMOTING FACTOR (172 aa), FASTA scores: E(): 1.9e-19, (42.9% identity in 147 aa overlap); Rv0867c|RPFA, Rv1884c|RPFC,and Rv2389c|RPFD. Possible lipoprotein; contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7VF01 No cell wall and cell processes Rv1009 NC_002945.3 Mycobrowser_v2 CDS 1133785 1134360 . - 0 Mb1042c pth PROBABLE PEPTIDYL-TRNA HYDROLASE PTH Mb1042c, pth, len: 191 aa. Equivalent to Rv1014c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 191 aa overlap). Probable pth,peptidyl-tRNA hydrolase (EC 3.1.1.29), similar to PTH_ECOLI|P23932 peptidy l-trna hydrolase from Escherichia coli (194 aa), FASTA scores: opt: 472, E(): 2.3e-25,(39.6% identity in 187 aa overlap). BELONGS TO THE PTH FAMILY. X2BGI9,P65866 No NC_002945.3 Mycobrowser_v2 CDS 1129603 1130556 . + 0 Mb1037 ksgA PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase) Mb1037, ksgA, len: 317 aa. Equivalent to Rv1010,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 317 aa overlap). Probable ksgA,dimethyladenosine transferase (EC 2.1.1.-), similar to many e.g. KSGA_BACSU|P37468 dimethyladenosine transferase from Bacillus subtilus (292 aa), FASTA scores: opt: 524,E(): 1.5e-28, (37.2% identity in 274 aa overlap); similar to Mycobacterium tuberculosis hypothetical protein Rv1988. Contains PS01131 Ribosomal RNA adenine dimethylases signature. X2BGQ3,P66661 No information pathways Rv1010 NC_002945.3 Mycobrowser_v2 CDS 1576898 1577380 . + 0 Mb1439 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1439, -, len: 160 aa. Equivalent to Rv1404, len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 160 aa overlap). Probable transcriptional regulatory protein, some similarity to MARR_ECOLI|P27245 multiple antibiotic resistance protein from Escherichia coli (125 aa), FASTA scores: opt: 136,E(): 0.004, (35.1% identity in 74 aa overlap). Q7U045 No regulatory proteins Rv1404 NC_002945.3 Mycobrowser_v2 CDS 1130642 1131562 . + 0 Mb1038 ispE Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ISPE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) Mb1038, ispE, len: 306 aa. Equivalent to Rv1011,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 306 aa overlap). Probable ispE,4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.-), similar to others e.g. Q9K3R6|ISPE_STRCO Streptomyces coelicolor (299 aa), FASTA scores: opt: 925,E(): 2.7e-49, (54.5% identity in 297 overlap); etc. BELONGS TO THE ISPE FAMILY. X2BGV6,P65179 No intermediary metabolism and respiration Rv1011 NC_002945.3 Mycobrowser_v2 CDS 1131559 1131873 . + 0 Mb1040 HYPOTHETICAL PROTEIN Mb1040, -, len: 104 aa. Equivalent to the 3' end of Rv1012, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv, (98.4% identity in 63 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a different NH2 terminus. Q7U0V2 No NC_002945.3 Mycobrowser_v2 CDS 1132077 1133711 . + 0 Mb1041 pks16 PUTATIVE POLYKETIDE SYNTHASE PKS16 Mb1041, pks16, len: 544 aa. Equivalent to Rv1013,len: 544 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 544 aa overlap). Putative pks16,polyketide synthase, similar to many e.g. N-terminus of Q50857|U24657 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa), FASTA scores: opt: 526, E(): 1.4e-25, (29.3% identity in 542 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U0V1 No NC_002945.3 Mycobrowser_v2 CDS 1134373 1135020 . - 0 Mb1043c rplY 50s ribosomal protein l25 rply Mb1043c, rplY, len: 215 aa. Equivalent to Rv1015c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Probable rplY, 50s ribosomal protein L25, similar to RL25_ECOLI|P02426 50s ribosomal protein L25 from Escherichia coli (94 aa), FASTA scores: opt: 182, E(): 2.5e-05, (38.4% identity in 86 aa overlap) and to CTC_BACSU|P14194 general stress protein from Bacillus subtilis (203 aa), FASTA scores: opt: 260,E(): 1.4e-09, (28.4% identity in 201 aa overlap). BELONGS TO THE L25P FAMILY OF RIBOSOMAL PROTEINS. X2BGQ7,P66122 No NC_002945.3 Mycobrowser_v2 CDS 1169872 1171119 . + 0 Mb1076 probable transposase Mb1076, -, len: 415 aa. Equivalent to Rv1047, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). IS1081 transposase,most similar to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa), FASTA scores: opt: 2675, E(): 0, (99.8% identity in 415 aa overlap). Contains PS01007 Transposases, Mutator family, signature X2BGW7,P60231 No insertion seqs and phages Rv1047 NC_002945.3 Mycobrowser_v2 CDS 1135154 1135912 . - 0 Mb1044c lpqT probable conserved lipoprotein lpqt Mb1044c, lpqT, len: 252 aa. Equivalent to 5' end of Rv1016c, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv, (98.9% identity in 190 aa overlap). Probable lpqT, conserved lipoprotein. Similar to several M. tuberculosis hypothetical proteins e.g. Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310 aa), FASTA scores: opt: 329, E(): 2e-17, (32.3% identity in 229 aa overlap); Rv0583c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cacgc-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. X2BGW0,Q7U0V0 No NC_002945.3 Mycobrowser_v2 CDS 1135948 1136928 . - 0 Mb1045c prsA PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE PRSA (Phosphoribosyl pyrophosphate synthetase) (PRPP synthetase) Mb1045c, prsA, len: 326 aa. Equivalent to Rv1017c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable prsA,ribose-phosphate pyrophosphokinase (EC 2.7.6.1), highly similar to others e.g. KPRS_ECOLI|P08330 ribose-phosphate pyrophosphokinase from Escherichia coli (314 aa), FASTA scores: opt: 826, E(): 0, (43.8% identity in 317 aa overlap). Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature; contains PS00144 Asparaginase / glutaminase active site signature 1. BELONGS TO THE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE FAMILY. COFACTOR: BOTH INORGANIC PHOSPHATE AND MAGNESIUM ION ARE REQUIRED FOR ENZYME STABILITY AND ACTIVITY (by similarity). X2BH02,P65233 No NC_002945.3 Mycobrowser_v2 CDS 1165019 1165570 . - 0 Mb1070c probable is like-2 transposase Mb1070c, -, len: 183 aa. Equivalent to Rv1041c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 183 aa overlap). Probable IS like-2 transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (186 aa), FASTA scores: opt: 173, E(): 0.00016, (40.9% identity in 176 aa overlap). Similar to Rv1150, C-terminal part of transposase of putative Mycobacterium tuberculosis IS like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with respect to Mycobacterium tuberculosis Q50761 transposase,the 10G2 cosmid sequence appears to be correct. No insertion seqs and phages Rv1041c NC_002945.3 Mycobrowser_v2 CDS 1137020 1138507 . - 0 Mb1046c glmU Probable UDP-N-acetylglucosamine pyrophosphorylase glmU Mb1046c, glmU, len: 495 aa. Equivalent to Rv1018c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 495 aa overlap). Probable glmU,UDP-n-acetylglucosamine pyrophosphorylase (EC 2.7.7.23),similar to GCAD_BACSU|P14192 UDP-n-acetylglucosamine pyrophosphorylase (456 aa), FASTA scores: opt: 1150, E(): 0, (40.0% identity in 453 aa overlap). Similar to various Mycobacterium tuberculosis sugar-phosphate transferases e.g. Rv0334, Rv1213, Rv3264c, etc. X2BGT8,Q7VF00 No NC_002945.3 Mycobrowser_v2 tRNA 1138523 1138594 . - 0 glnT glnT tRNA-Gln glnT, len: 72 nt. Equivalent to glnT, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Gln, anticodon ttg. No NC_002945.3 Mycobrowser_v2 CDS 1138762 1139355 . + 0 Mb1047 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Mb1047, -, len: 197 aa. Equivalent to Rv1019, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 197 aa overlap). Probable transcriptional regulator, similar to many memebers of the tetR family e.g. MTCY7D11.18c (34.4% identity in 189 aa overlap). Helix turn helix motif from aa 27-48 (+5.42 SD). Q7U0U9 No regulatory proteins Rv1019 NC_002945.3 Mycobrowser_v2 CDS 1139414 1143118 . + 0 Mb1048 mfd PROBABLE TRANSCRIPTION-REPAIR COUPLING FACTOR MFD (TRCF) Mb1048, mfd, len: 1234 aa. Equivalent to Rv1020,len: 1234 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1234 aa overlap). Probable mfd,transcription-repair coupling factor, similar to many e.g. MFD_ECOLI|P30958 transcription-repair coupling factor from Escherichia coli (1148 aa), FASTA scores: opt: 1900, E(): 0, (37.9% identity in 1107 aa overlap). Also similar to M. tuberculosis Rv2973c and Rv1633. Contains PS00017 ATP/GTP-binding site motif A (P-loop). IN THE N-TERMINAL SECTION; BELONGS TO THE UVRB FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HELICASE FAMILY. RECG SUBFAMILY. X2BGR0,P64327 No information pathways Rv1020 NC_002945.3 Mycobrowser_v2 CDS 1143118 1144095 . + 0 Mb1049 conserved protein Mb1049, -, len: 325 aa. Equivalent to Rv1021, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 325 aa overlap). Conserved hypothetical protein, similar to YBL1_STRCI|P33653 hypothetical 26.1 kd protein from Streptomyces cacaoi (242 aa), FASTA scores: opt: 493, E(): 1.1e-23, (42.9% identity in 238 aa overlap). Q7U0U8 No conserved hypotheticals Rv1021 NC_002945.3 Mycobrowser_v2 CDS 1144183 1144914 . + 0 Mb1050 lpqU probable conserved lipoprotein lpqu Mb1050, lpqU, len: 243 aa. Equivalent to Rv1022,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 243 aa overlap). Probable lpqU conserved lipoprotein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1230c|MTV006.02C,FASTA scores: E(): 2.8e-18, (37.9% identity in 240 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa), FASTA scores: opt: 474, E(): 2.7e-21, (42.2% identity in 211 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7U0U7 No cell wall and cell processes Rv1022 NC_002945.3 Mycobrowser_v2 CDS 1145011 1146300 . + 0 Mb1051 eno PROBABLE ENOLASE ENO Mb1051, eno, len: 429 aa. Equivalent to Rv1023,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 429 aa overlap). Probable eno, enolase (EC 4.2.1.11), highly similar to others e.g. ENO_ECOLI|P08324 enolase from Escherichia coli (431 aa),FASTA scores: opt: 1487, E(): 0, (55.5% identity in 422 aa overlap); etc. MAGNESIUM IS REQUIRED FOR CATALYSIS AND FOR STABILIZING THE DIMER. BELONGS TO THE ENOLASE FAMILY. X2BGU2,Q7U0U6 No intermediary metabolism and respiration Rv1023 NC_002945.3 Mycobrowser_v2 CDS 1146305 1146991 . + 0 Mb1052 possible conserved membrane protein Mb1052, -, len: 228 aa. Equivalent to Rv1024, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Hypothetical unknown protein, hydrophobic region from aa 83-101. Q7U0U5 No cell wall and cell processes Rv1024 NC_002945.3 Mycobrowser_v2 CDS 1147008 1147475 . + 0 Mb1053 conserved protein Mb1053, -, len: 155 aa. Equivalent to Rv1025, len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 155 aa overlap). Conserved hypothetical protein, similar to AE001768|AE001768_4 hypothetical protein from Thermotoga maritima (170 aa), FASTA scores: opt: 254, E(): 9.5e-10, (35.7% identity in 143 aa overlap). Q7U0U4 No conserved hypotheticals Rv1025 NC_002945.3 Mycobrowser_v2 CDS 1148874 1149554 . - 0 Mb1055c kdpE PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN KDPE Mb1055c, kdpE, len: 226 aa. Equivalent to Rv1027c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 226 aa overlap). Probable KdpE,transcriptional regulatory protein, similar to others e.g. KDPE_ECOLI|P21866 kdp operon transcriptional regulatory protein from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 691, E(): 0, (47.8% identity in 224 aa overlap); AL021530|SC2E9.13 from Streptomyces coelicolor (227 aa), FASTA scores: opt: 981, E(): 0, (66.4% identity in 226 aa overlap); etc. Q7U0U2 No NC_002945.3 Mycobrowser_v2 CDS 1149551 1152133 . - 0 Mb1056c kdpD PROBABLE SENSOR PROTEIN KDPD Mb1056c, kdpD, len: 860 aa. Equivalent to Rv1028c,len: 860 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 860 aa overlap). Probable kdpD, sensor protein (EC 2.7.3.-), similar to others e.g. KDPD_ECOLI|P21865 sensor protein from Escherichia coli strain K12 (894 aa), FASTA scores: opt: 1041, E(): 0,(32.3% identity in 888 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7U0U1 No NC_002945.3 Mycobrowser_v2 CDS 1152367 1152459 . + 0 Mb1057 kdpF Probable membrane protein kdpF Mb1057, kdpF, len: 30 aa. Equivalent to Rv1028A,len: 30 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 30 aa overlap). Probable kdpF, membrane protein, showing similarity with P36937|KDPF_ECOLI|B0698.1 PROTEIN KDPF from Escherichia coli strain K12 (see citation below) (27% identity); and KdpF protein from Streptomyces coelicolor (51% identity). Q7VEZ9 No cell wall and cell processes Rv1028A NC_002945.3 Mycobrowser_v2 CDS 1152459 1154174 . + 0 Mb1058 kdpA Probable Potassium-transporting ATPase A chain KDPA (Potassium-translocating ATPase A chain) (ATP phosphohydrolase [potassium-transporting] A chain) (Potassium binding and translocating subunit A) Mb1058, kdpA, len: 571 aa. Equivalent to Rv1029,len: 571 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 571 aa overlap). Probable kdpA,potassium-transporting ATPase A chain (transmembrane protein) (EC 3.6.3.12), similar to others e.g. ATKA_ECOLI|P03959|KDPA|B0698 potassium-transporting ATPase A chain from Escherichia coli strain K12 (557 aa), FASTA scores: opt: 1763, E(): 0, (50.4% identity in 569 aa overlap); etc. BELONGS TO THE KDPA FAMILY. X2BGR6,P65210 No cell wall and cell processes Rv1029 NC_002945.3 Mycobrowser_v2 CDS 1154171 1156300 . + 0 Mb1059 kdpB Probable Potassium-transporting P-type ATPase B chain KDPB (Potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium binding and translocating subunit B) Mb1059, kdpB, len: 709 aa. Equivalent to Rv1030,len: 709 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 709 aa overlap). Probable kdpB,potassium-transporting P-type ATPase B chain (transmembrane protein) (EC 3.6.3.12), similar to others e.g. ATKB_ECOLI|P03960 potassium-transporting ATPase B chain from Escherichia coli strain K12 (682 aa), FASTA scores: opt: 1481, E(): 0, (63.4% identity in 686 aa overlap); etc. Very similar to AL078610|SCH35.47 H+/K+-exchanging ATPase (EC 3.6.1.36) chain B from Streptomyces coelicolor (707 aa), FASTA scores: opt: 2731,E(): 0, (71.6% identity in 676 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site. X2BGX3,P63682 No cell wall and cell processes Rv1030 NC_002945.3 Mycobrowser_v2 CDS 1156300 1156869 . + 0 Mb1060 kdpC Probable Potassium-transporting ATPase C chain KDPC (Potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (Potassium binding and translocating subunit C) Mb1060, kdpC, len: 189 aa. Equivalent to Rv1031,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 189 aa overlap). Probable kdpC,potassium-transporting ATPase C chain (membrane protein) (EC 3.6.3.12), similar to others e.g. ATKC_ECOLI|P03961 potassium-transporting ATPase C chain from Escherichia coli strain K12 (190 aa), FASTA scores: opt: 475, E(): 3.1e-24, (45.7% identity in 186 aa overlap); etc. BELONGS TO THE KDPC FAMILY. X2BH18,P65212 No cell wall and cell processes Rv1031 NC_002945.3 Mycobrowser_v2 CDS 1156873 1158402 . - 0 Mb1061c trcS TWO COMPONENT SENSOR HISTIDINE KINASE TRCS Mb1061c, trcS, len: 509 aa. Equivalent to Rv1032c,len: 509 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 509 aa overlap). trcS, two component sensor histidine kinase protein (EC 2.7.3.-) (see citations below), similar to YV16_MYCLE|P54883 probable sensor-like histidine kinase from Mycobacterium leprae (443 aa), FASTA scores: opt: 392, E(): 3.8e-18, (31.7% identity in 334 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+. Q7U0U0 No NC_002945.3 Mycobrowser_v2 CDS 1158410 1159183 . - 0 Mb1062c trcR TWO COMPONENT TRANSCRIPTIONAL REGULATOR TRCR Mb1062c, trcR, len: 257 aa. Equivalent to Rv1033c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). trcR, two-component regulatory protein (see citations below), similar to Q50825 TWO COMPONENT RESPONSE REGULATOR from Mycobacterium tuberculosis (234 aa), FASTA scores: opt: 628, E(): 0,(46.0% identity in 226 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+. Q7U0T9 No NC_002945.3 Mycobrowser_v2 CDS 1159365 1159754 . - 0 Mb1063c PROBABLE TRANSPOSASE (FRAGMENT) Mb1063c, -, len: 129 aa. Equivalent to Rv1034c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Probable IS1560 transposase fragment, similar to part of Rv3387|E1202305|MTV004.45 (225 aa) (65.1% identity in 129 aa overlap). Q7U0T8 No insertion seqs and phages Rv1034c NC_002945.3 Mycobrowser_v2 CDS 1159822 1160508 . - 0 Mb1064c PROBABLE TRANSPOSASE (FRAGMENT) Mb1064c, -, len: 228 aa. Equivalent to Rv1035c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Probable IS1560 transposase fragment, similar to parts of Rv3387|E1202305|MTV004.45 (225 aa) (47.8% identity in 67 aa overlap) and Rv3386|E1202304|MTV004.44 (234 aa) (55.1% identity in 127 aa overlap). Q7U0T7 No insertion seqs and phages Rv1035c NC_002945.3 Mycobrowser_v2 CDS 1160542 1160880 . - 0 Mb1065c PROBABLE IS1560 TRANSPOSASE (FRAGMENT) Mb1065c, -, len: 112 aa. Equivalent to Rv1036c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 112 aa overlap). Probable IS1560 transposase fragment, similar to part of Rv3386|E1202304|MTV004.44 (234 aa) (82.8% identity in 87 aa overlap). Q7U0T6 No insertion seqs and phages Rv1036c NC_002945.3 Mycobrowser_v2 CDS 1160991 1161275 . - 0 Mb1066c esxI putative esat-6 like protein esxi (esat-6 like protein 1) Mb1066c, esxI, len: 94 aa. Equivalent to Rv1037c,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 94 aa overlap). esxI, conserved hypothetical protein, member of ESAT-6 family, highly similar to many Mycobacterial hypothetical proteins e.g. Q49946|ES6X_MYCLE|U1756D PUTATIVE ESAT-6 LIKE PROTEIN X from Mycobacterium leprae (95 aa), FASTA scores: opt: 409,E(): 6.3e-23, (64.15% identity in 92 aa overlap); Rv3619c,Rv1198, Rv2346c, etc from Mycobacterium tuberculosis. Strictly identical to P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT3721 PUTATIVE ESAT-6 LIKE PROTEIN 1 (94 aa). BELONGS TO THE ESAT6 FAMILY. X2BGV7 No NC_002945.3 Mycobrowser_v2 CDS 1161302 1161598 . - 0 Mb1067c esxJ esat-6 like protein esxj (esat-6 like protein 2) Mb1067c, esxJ, len: 98 aa. Equivalent to Rv1038c,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 98 aa overlap). esxJ, putative ESAT-6 like protein 2, similar to Q49945|U1756C, Mycobacterium leprae (100 aa), FASTA scores: opt: 375, E(): 7.7e-21,(58.3% identity in 96 aa overlap), almost identical to Rv1197, Rv1792, Rv2347c and Rv3620c. BELONGS TO THE ESAT6 FAMILY. X2BGJ8 No NC_002945.3 Mycobrowser_v2 CDS 1161744 1162919 . - 0 Mb1068c PPE15 ppe family protein ppe15 Mb1068c, PPE15, len: 391 aa. Equivalent to Rv1039c,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 391 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv2768c|AL008967|MTV002_33 Mycobacterium tuberculosis H37Rv (394 aa), FASTA scores: opt: 1721, E(): 0, (70.4% identity in 398 aa overlap). Q7U0T5 No NC_002945.3 Mycobrowser_v2 CDS 1162996 1163823 . - 0 Mb1069c PE8 pe family protein pe8 Mb1069c, PE8, len: 275 aa. Equivalent to Rv1040c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Member of the Mycobacterium tuberculosis PE family, most similar to AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 aa), FASTA scores: opt: 1111, E(): 0, (68.6% identity in 283 aa overlap). Q7U0T4 No NC_002945.3 Mycobrowser_v2 CDS 1166229 1167254 . - 0 Mb1072c CONSERVED HYPOTHETICAL PROTEIN Mb1072c, -, len: 341 aa. Equivalent to Rv1043c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 341 aa overlap). Conserved hypothetical protein similar to AL096872|SC5F7.08 PUTATIVE LIPOATE-PROTEIN LIGASE from Streptomyces coelicolor (362 aa), FASTA scores: opt: 206, E(): 1.4e-05, (30.3% identity in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU HYPOTHETICAL PROTEASE from Bacillus subtitis (400 aa),FASTA scores: opt: 159, E(): 0.013, (27.1% identity in 210 aa overlap). Q7U0T2 No conserved hypotheticals Rv1043c NC_002945.3 Mycobrowser_v2 CDS 1167501 1168124 . + 0 Mb1073 CONSERVED HYPOTHETICAL PROTEIN Mb1073, -, len: 207 aa. Equivalent to Rv1044, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 207 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap). Q7U0T1 No conserved hypotheticals Rv1044 NC_002945.3 Mycobrowser_v2 CDS 1174393 1175148 . - 0 Mb1080c CONSERVED HYPOTHETICAL PROTEIN Mb1080c, -, len: 251 aa. Equivalent to Rv1051c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 251 aa overlap). Conserved hypothetical protein, similar to LLU36837|U36837.1 protein encoded by Lactococcus lactis plasmid pNP40 (298 aa), FASTA scores: opt: 194, E(): 3.5e-06, (30.3% identity in 155 aa overlap). Contains possible helix-turn-helix motif at aa 197-218 (Score 1097, +2.92 SD). Q7U0S5 No conserved hypotheticals Rv1051c NC_002945.3 Mycobrowser_v2 CDS 1176171 1176560 . + 0 Mb1081 HYPOTHETICAL PROTEIN Mb1081, -, len: 129 aa. Equivalent to Rv1052, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Hypothetical unknown protein. Q7U0S4 No conserved hypotheticals Rv1052 NC_002945.3 Mycobrowser_v2 CDS 1176459 1176734 . - 0 Mb1082c HYPOTHETICAL PROTEIN Mb1082c, -, len: 91 aa. Equivalent to Rv1053c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 91 aa overlap). Hypothetical unknown protein. Q7U0S3 No conserved hypotheticals Rv1053c NC_002945.3 Mycobrowser_v2 CDS 1177376 1177690 . + 0 Mb1083 probable integrase (fragment) Mb1083, -, len: 104 aa. Equivalent to Rv1054, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable integrase (fragment), similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 273, E(): 8.8e-13, (64.7% identity in 68 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa), FASTA scores: opt: 105, E(): 0.9, (31.8% identity in 85 aaoverlap). This ORF continues in another frame as Rv1055|MTV017.08 but no error can be found to account for frameshift. Length extended since first submission (+36 aa). Q7U0S2 No insertion seqs and phages Rv1054 NC_002945.3 Mycobrowser_v2 CDS 1177687 1177821 . + 0 Mb1084 POSSIBLE INTEGRASE (FRAGMENT) Mb1084, -, len: 44 aa. Equivalent to Rv1055, len: 44 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 44 aa overlap). Possible integrase (fragment); first 49 aa similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 291, E(): 2.2e-16, (74.3% identity in 70 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa),FASTA scores: opt: 146, E(): 8.3e-05, (52.1% identity in 48 aa overlap); and to many other integrases or transposases. Shortened since first submission (-34 aa). Q7U0S1 No insertion seqs and phages Rv1055 NC_002945.3 Mycobrowser_v2 CDS 1178076 1178840 . + 0 Mb1085 conserved protein Mb1085, -, len: 254 aa. Equivalent to Rv1056, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 254 aa overlap). Conserved hypothetical protein, some similarity in C-terminal region of Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126 aa), FASTA scores: opt: 254, E(): 1.2e-10, (43.4% identity in 106 aa overlap); and to Rv1670. C-terminal region is similar to AL035569|SC8D9.02 hypothetical protein from Streptomyces coelicolor (113 aa), FASTA scores: opt: 282,E(): 4.5e-12, (48.0% identity in 100 aa overlap). Q7U0S0 No conserved hypotheticals Rv1056 NC_002945.3 Mycobrowser_v2 CDS 1188446 1188841 . + 0 Mb1095 CONSERVED HYPOTHETICAL PROTEIN Mb1095, -, len: 131 aa. Equivalent to Rv1066, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 131 aa overlap). Conserved hypothetical protein, strong similarity to AL0209|SC4H8.10 hypothetical protein from Streptomyces coelicolor (132 aa), FASTA scores: opt: 429, E(): 5.2e-23, (57.1% identity in 119 aa overlap). Q7U0R2 No conserved hypotheticals Rv1066 NC_002945.3 Mycobrowser_v2 CDS 1179844 1181025 . + 0 Mb1086 CONSERVED HYPOTHETICAL PROTEIN Mb1086, -, len: 393 aa. Equivalent to Rv1057, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Conserved hypothetical protein, some similarity to X84710|MMSAG_1 surface antigen of Methanosarcina mazeii (491 aa), FASTA scores: opt: 363,E():6.2e-15, (31.3% identity in 294 aa overlap). Q7U0R9 No conserved hypotheticals Rv1057 NC_002945.3 Mycobrowser_v2 CDS 2064407 2064901 . + 0 Mb1860 conserved protein Mb1860, -, len: 164 aa. Equivalent to Rv1829, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Conserved hypothetical protein, equivalent to O32917|MLCB1788.34|AL008609 Hypothetical protein from Mycobacterium leprae (164 aa),FASTA scores: opt: 1011, E(): 0, (95.1% identity in 164 aa overlap). Also present in Aquifex aeolicus, etc. Q7TZG7 No conserved hypotheticals Rv1829 NC_002945.3 Mycobrowser_v2 CDS 1181132 1182763 . + 0 Mb1087 fadD14 PROBABLE MEDIUM CHAIN FATTY-ACID-COA LIGASE FADD14 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE) Mb1087, fadD14, len: 543 aa. Equivalent to Rv1058,len: 543 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 543 aa overlap). Probable fadD14,medium-chain fatty-acid-CoA synthetase (EC 6.2.1.-),highly similar to many e.g. CAC32346.1|AL583945 putative fatty acid CoA ligase from Streptomyces coelicolor (558 aa); N-terminus of NP_419738.1|NC_002696 medium-chain-fatty-acid--CoA ligase from Caulobacter crescentus (1006 aa); Q00594|ALKK_PSEOL MEDIUM-CHAIN-FATTY-ACID--COA LIGASE (EC 6.2.1.-) from Pseudomonas oleovorans (546 aa), FASTA scores: opt: 1468,E(): 0, (41.1% identity in 538 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Q7U0R8 No NC_002945.3 Mycobrowser_v2 CDS 1182839 1183903 . + 0 Mb1088 conserved protein Mb1088, -, len: 354 aa. Equivalent to Rv1059, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Conserved hypothetical protein, similar to Rv0926c|MTCY21C12.20c hypothetical protein from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 338, E(): 1.4e-14, (33.1% identity in 363 aa overlap). Q7U0R7 No conserved hypotheticals Rv1059 NC_002945.3 Mycobrowser_v2 CDS 1183956 1184429 . + 0 Mb1089 unknown protein Mb1089, -, len: 157 aa. Equivalent to Rv1060, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 157 aa overlap). Hypothetical unknown protein. Q7U0R6 No conserved hypotheticals Rv1060 NC_002945.3 Mycobrowser_v2 CDS 1184463 1185326 . + 0 Mb1090 conserved protein Mb1090, -, len: 287 aa. Equivalent to Rv1061, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 287 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from various bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803 (304 aa), FASTA scores: opt: 245, E(): 1.2e-09, (27.1% identity in 258 aa overlap). Q7U0R5 No conserved hypotheticals Rv1061 NC_002945.3 Mycobrowser_v2 CDS 1186189 1187271 . - 0 Mb1092c CONSERVED HYPOTHETICAL PROTEIN Mb1092c, -, len: 360 aa. Equivalent to Rv1063c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Conserved hypothetical protein, similar to P37053|YCHK_ECOLI hypothetical protein from Escherichia coli (314 aa), FASTA scores: opt: 487,E(): 7.2e-23, (32.7% identity in 321 aa overlap). Also partially similar to Rv3239c|MTCY20B11.14c. BELONGS TO THE UPF0028 (SWS) FAMILY. X2BGK7,P67099 No conserved hypotheticals Rv1063c NC_002945.3 Mycobrowser_v2 CDS 1187352 1187771 . - 0 Mb1093c lpqV possible lipoprotein lpqv Mb1093c, lpqV, len: 139 aa. Equivalent to Rv1064c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 139 aa overlap). Putative lipoprotein LpqV. Has N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. X2BGU0,P65311 No NC_002945.3 Mycobrowser_v2 CDS 1188869 1190884 . - 0 Mb1096c PE_PGRS19 pe-pgrs family protein pe_pgrs19 Mb1096c, PE_PGRS19, len: 671 aa. Equivalent to Rv1067c, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (98.5% identity in 673 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv3388|MTV004.46 from Mycobacterium tuberculosis (731 aa),FASTA scores: opt: 2227, E(): 0, (55.6% identity in 710 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1, probably fortuitous. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions each of 3 bp (ccg-* and cgc-*) and a 18 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa). Q7U0R1 No NC_002945.3 Mycobrowser_v2 CDS 1191217 1193508 . - 0 Mb1097c PE_PGRS20 pe-pgrs family protein pe_pgrs20 Mb1097c, PE_PGRS20, len: 763 aa. Similar to Rv1068c, len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, (59.8% identity in 766 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AL021897|MTV017_19 M. tuberculosis H37Rv (667 aa), FASTA scores: opt: 1875, E(): 0, (55.0% identity in 667 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). Q7U0R0 No NC_002945.3 Mycobrowser_v2 CDS 1193870 1195633 . - 0 Mb1098c conserved protein Mb1098c, -, len: 587 aa. Equivalent to Rv1069c,len: 587 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 587 aa overlap). Conserved hypothetical protein, hydrophobic regions in N-terminal domain. Similar in part to O07136|B1306.04C B1306.04c protein from Mycobacterium leprae (89 aa), FASTA scores: opt: 229, E(): 1.3e-07, (54.2% identity in 72 aa overlap). Q7U0Q9 No conserved hypotheticals Rv1069c NC_002945.3 Mycobrowser_v2 CDS 1216980 1217435 . + 0 Mb1120 celA2b PROBABLE CELLULASE CELA2B (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE) Mb1120, celA2b, len: 151 aa. Equivalent to Rv1090,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 151 aa overlap). Probable celA2b, second part of cellulase (endoglucanase) (EC 3.2.1.4), similar to C-terminus of others e.g. O08468 cellulase CEL2 from Streptomyces halstedi (377 aa), FASTA scores: opt: 554,E(): 1.2e-30, (52.0% identity in 152 aa overlap); etc. Gene appears to have been inactivated by frameshift mutations but no errors could be found that would account for this. Q7U0P2 No NC_002945.3 Mycobrowser_v2 CDS 1199516 1200733 . - 0 Mb1103c fadA3 PROBABLE BETA-KETOACYL CoA THIOLASE FADA3 Mb1103c, fadA3, len: 405 aa. Equivalent to Rv1074c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 405 aa overlap). Probable fadA3,beta-ketoacyl CoA thiolase (EC 2.3.1.-), highly similar to many involved in beta-oxidation e.g. CAB89028.1|AL353870 beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor (395 aa); P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA thiolase from Escherichia coli (401 aa), FASTA scores: opt: 1034, E(): 5.4e-56, (43.5% identity in 416 aa overlap) and X97452 acetyl-CoA acetyltransferase (thiolase) from Escherichia coli (401 aa), FASTA scores: opt: 1043, E(): 0, (43.4% identity in 415 aa overlap); Q43935|CATF_ACICA beta-ketoadipyl CoA thiolase from Acinetobacter calcoaceticus (401 aa), FASTA scores: opt: 992, E(): 0, (41.5% identity in 415 aa overlap); etc. Contains PS00737 Thiolases signature 2, and PS00445 FGGY family of carbohydrate kinases signature 2, although this is probably fortuitous. BELONGS TO THE THIOLASE FAMILY. Q7U0Q5 No NC_002945.3 Mycobrowser_v2 CDS 1195630 1196403 . - 0 Mb1099c echA8 PROBABLE ENOYL-CoA HYDRATASE ECHA8 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) Mb1099c, echA8, len: 257 aa. Equivalent to Rv1070c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Probable echA8,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to O07137|B1306.05c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (257 aa), FASTA scores: opt: 1417, E(): 0, (86.4% identity in 257 aa overlap). Also highly similar to others e.g. NP_106219.1|NC_002678 enoyl CoA hydratase from Mesorhizobium loti (257 aa); L39265|RHMRPST_2 enoyl-CoA hydratase from Rhizobium melilotii (257 aa), FASTA scores: opt: 1100, E(): 0,(66.9% identity in 257 aa overlap); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa); etc. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-CoA HYDRATASE/ISOMERASE FAMILY. TBparse score is 0.881. X2BGZ4,P64017 No NC_002945.3 Mycobrowser_v2 CDS 1196415 1197452 . - 0 Mb1100c echA9 POSSIBLE ENOYL-COA HYDRATASE ECHA9 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb1100c, echA9, len: 345 aa. Equivalent to Rv1071c,len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 345 aa overlap). Possible echA9,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (350 aa); Q19278 PROTEIN SIMILAR TO ENOYL-COA HYDRATASES from Caenorhabditis elegans (386), FASTA scores: opt: 787, E(): 0, (38.5% identity in 348 aa overlap); etc. Q7U0Q8 No NC_002945.3 Mycobrowser_v2 CDS 1197639 1198475 . + 0 Mb1101 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Mb1101, -, len: 278 aa. Equivalent to Rv1072, len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 278 aa overlap). Probable conserved transmembrane protein, equivalent to O07139|B1306.07|Y13803 Protein B1306.07 from Mycobacterium leprae (220 aa), FASTA scores: opt:1032, E(): 0, (75.0% identity in 220 aa overlap); and at the C-terminal end to Q50056|U1740D Mycobacterium leprae (96 aa), FASTA scores: opt: 381, E(): 1.2e-18, (71.6% identity in 81 aa overlap). Similar to Q54192|M80628|STMBLDA_1 TRANSFER RNA-LEU (BLDA) GENE AND ORF from Streptomyces griseus (293 aa), FASTA scores: opt:558, E(): 4.7e-30, (41.5% identity in 299 aa overlap). TBparse score is 0.896. Q7U0Q7 No cell wall and cell processes Rv1072 NC_002945.3 Mycobrowser_v2 CDS 1198591 1199442 . + 0 Mb1102 CONSERVED HYPOTHETICAL PROTEIN Mb1102, -, len: 283 aa. Equivalent to Rv1073, len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 283 aa overlap). Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03 Mycobacterium tuberculosis (339 aa), FASTA scores: opt: 810, E(): 0,(47.4% identity in 272 aa overlap); Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289 aa), FASTA scores: opt: 704, E(): 0, (44.4% identity in 259 aa overlap); and Rv3517, etc., and GIR10|AF002133_10 M. avium strain GIR10 (346 aa), FASTA scores: opt: 802,E(): 0, (48.1% identity in 270 aa overlap). Q7U0Q6 No conserved hypotheticals Rv1073 NC_002945.3 Mycobrowser_v2 CDS 1200786 1201730 . - 0 Mb1104c CONSERVED EXPORTED PROTEIN Mb1104c, -, len: 314 aa. Equivalent to Rv1075c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 314 aa overlap). Possibly exported protein, as it contains a N-terminal signal sequence,hydrophobic domain from aa 7-25. Similar to U15183|MLU15183_2 Mycobacterium leprae cosmid B1740 (106 aa), FASTA scores: opt: 207, E(): 1.6e-06, (42.6% identity in 101 aa overlap). Also weak similarity to many glyceraldehyde-3-phosphate dehydrogenases e.g. Q41595|G3PC_TAXBA Taxus baccata (340 aa), FASTA scores: opt: 147, E(): 0.027, (27.5% identity in 189 aa overlap). Q7U0Q4 No cell wall and cell processes Rv1075c NC_002945.3 Mycobrowser_v2 CDS 1202127 1203020 . + 0 Mb1105 lipU possible lipase lipu Mb1105, lipU, len: 297 aa. Equivalent to Rv1076,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 297 aa overlap). Putative lipU, lipase (EC 3.1.-.-), very similar to several Mycobacterium tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c (277 aa), FASTA scores: opt: 1225, E(): 0, (76.0% identity in 246 aa overlap); Rv1426c, etc. Also similar to esterases and lipases of around 300 aa e.g. Q44087 ESTERASE PRECURSOR from Acinetobacter lwoffii esterase (303), FASTA scores: opt: 427, E(): 1.9e-21, (32.5% identity in 280 aa overlap). Equivalent to AL035159|MLCB1450 _7 Mycobacterium leprae (335 aa), FASTA scores: opt: 1588, E(): 0, (79.7% identity in 296 aa overlap). Q7U0Q3 No intermediary metabolism and respiration Rv1076 NC_002945.3 Mycobrowser_v2 CDS 1203077 1204471 . + 0 Mb1106 cbs Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) Mb1106, cbs, len: 464 aa. Equivalent to Rv1077,len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 464 aa overlap). Probable cbs (previously cysM2), cystathionine beta-synthase (EC 4.2.1.22), similar throughout its length to many eukaryotic cystathionine beta-synthases e.g. P32232|CBS_RAT CYSTATHIONINE BETA-SYNTHASE (560 aa), FASTA scores: opt: 951, E(): 0, (40.2% identity in 450 aa overlap); also similar in N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 855, E(): 0, (46.8% identity in 314 overlap); and other cysteine synthase proteins e.g. Rv1336, Rv0848, etc. Contains PS00217 Sugar transport proteins signature 2 probably spurious. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Q7VEZ8 No intermediary metabolism and respiration Rv1077 NC_002945.3 Mycobrowser_v2 CDS 1204673 1205395 . + 0 Mb1107 pra Probable Proline-rich antigen homolog pra Mb1107, pra, len: 240 aa. Equivalent to Rv1078,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 240 aa overlap). Probable pra,Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1 proline rich antigen from Mycobacterium leprae (249 aa), FASTA scores: opt: 1162, E(): 3.3e-30,(64.8% identity in 253 aa overlap). Has potential hydrophobic domains. Q7U0Q2 No conserved hypotheticals Rv1078 NC_002945.3 Mycobrowser_v2 CDS 1215894 1216328 . + 0 Mb1117 PE9 pe family protein pe9 Mb1117, PE9, len: 144 aa. Equivalent to Rv1088,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Member of Mycobacterium tuberculosis PE family, similar to many others e.g. Z96071|MTCI418B_6 Mycobacterium tuberculosis cosmid (487 aa), FASTA scores: opt: 318, E(): 7.3e-14, (60.9% identity in 87 aa overlap) - except it appears to be frameshifted around codon 84. No error to account for frameshift could be found. Q7U0P5 No PE/PPE Rv1088 NC_002945.3 Mycobrowser_v2 CDS 1205427 1206593 . + 0 Mb1108 metB cystathionine gamma-synthase metb (cgs) (o-succinylhomoserine [thiol]-lyase) Mb1108, metB, len: 388 aa. Equivalent to Rv1079,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 388 aa overlap). Probable metB,cystathionine gamma-synthase (EC 4.2.99.9) (see citation below). P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE from Mycobacterium leprae (EC 4.2.1.22) (388 aa), FASTA scores: opt: 2220, E(): 0, (87.3% identity in 387 aa overlap). Also similar to other Mycobacterium tuberculosis enzymes involved in methionine synthesis e.g. Rv0391 and Rv3340. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. X2BGV2,P66876 No intermediary metabolism and respiration Rv1079 NC_002945.3 Mycobrowser_v2 CDS 1206664 1207158 . - 0 Mb1109c greA PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA (Transcript cleavage factor greA) Mb1109c, greA, len: 164 aa. Equivalent to Rv1080c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 164 aa overlap). Probable greA,transcription elongation factor G, closest to P46808|GREA_MYCLE TRANSCRIPTION ELONGATION FACTOR G from Mycobacterium leprae (202 aa), FASTA scores: opt: 1005,E(): 0, (94.5% identity in 164 aa overlap); and similar to many e.g. P21346|GREA_ECOLI from Escherichia coli (158 aa), FASTA scores: opt: 257, E(): 5.7e-10, (37.2% identity in 148 aa overlap); etc. Contains two PS00829 and one PS00830 Prokaryotic transcription elongation factors signatures 1 and 2, respectively. BELONGS TO THE GREA/GREB FAMILY. X2BH00,P64280 No NC_002945.3 Mycobrowser_v2 CDS 1207344 1207778 . - 0 Mb1110c PROBABLE CONSERVED MEMBRANE PROTEIN Mb1110c, -, len: 144 aa. Equivalent to Rv1081c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Probable conserved membrane protein, with hydrophobic stretch from aa 26 -48, highly similar to NP_302548.1|NC_002677 conserved membrane protein from Mycobacterium leprae. Q7U0Q1 No cell wall and cell processes Rv1081c NC_002945.3 Mycobrowser_v2 CDS 1207880 1208746 . + 0 Mb1111 mca Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) Mb1111, mca, len: 288 aa. Equivalent to Rv1082,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 288 aa overlap). mca, mycothiol conjugate amidase (see citation below), equivalent to NP_302547.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (290 aa), FASTA scores: opt: 1737,E(): 0, (86.4% identity in 287 aa overlap); and similar to Q54358|X79146 lmbE protein from Streptomyces lincolnensis (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins deacetylase from Mycobacterium tuberculosis (303 aa),FASTA scores: opt: 411, E(): 9.4e-20, (35.8% identity in 299 aa overlap). Q7VEZ7 No virulence, detoxification, adaptation Rv1082 NC_002945.3 Mycobrowser_v2 CDS 1230055 1230756 . + 0 Mb1130 conserved protein Mb1130, -, len: 233 aa. Equivalent to Rv1100, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 233 aa overlap). Conserved hypothetical protein, slightly similar to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 122, E(): 6.9, (27.4% identity in 135 aa overlap). Equivalent to AL049491|MLCB1222_9 Mycobacterium leprae (257 aa) (63.8% identity in 257 aa overlap). Q7U0N4 No conserved hypotheticals Rv1100 NC_002945.3 Mycobrowser_v2 CDS 1208996 1211017 . + 0 Mb1113 conserved protein Mb1113, -, len: 673 aa. Equivalent to Rv1084, len: 673 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 673 aa overlap). Conserved hypothetical protein, similar to P37512|YYAL_BACSU hypothetical protein from Bacillus subtilis (689 aa), FASTA scores: opt: 1063,E(): 0, (36.5% identity in 696 aa overlap); AE0009|AE000983_10 Archaeoglobus fulgidus section 1 (642 aa), FASTA scores: opt: 1018, E(): 0, (37.2% identity in 600 aa overlap). Also similar to AE001938|AE001938_9 Deinococcus radiodurans (690 aa), FASTA scores: opt: 1097,E(): 0, (41.6% identity in 694 aa overlap). Q7U0P9 No conserved hypotheticals Rv1084 NC_002945.3 Mycobrowser_v2 CDS 1211116 1211844 . - 0 Mb1114c POSSIBLE HEMOLYSIN-LIKE PROTEIN Mb1114c, -, len: 242 aa. Equivalent to Rv1085c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 242 aa overlap). Possible hemolysin-like protein, integral membrane protein, similar to many hemolysins, and hypothetical proteins e.g. U28375|ECU28375_49 Hypothetical protein from Escherichia coli (219 aa), FASTA scores: opt: 308, E(): 7.5e-15,(30.6% identity in 180 aa overlap); AE0011|HIAE001124_2 Hypothetical protein from Borrelia burgdorferi (233 aa),FASTA scores: opt: 305, E(): 1.3e-14, (25.6% identity in 203 aa overlap). Also weakly similar to HLY3_BACCE|P54176 haemolysin from Bacillus cereus (219 aa), FASTA scores: opt: 247, E(): 8.7e-12, (27.5% identity in 171 aa overlap). Also similar to AE002027|AE002027_8 probable hemolysin from Deinococcus radiodurans (219 aa), FASTA scores: opt: 354, E(): 1.8e-16, (31.1% identity in 219 aa overlap). X2BH03,P67158 No virulence, detoxification, adaptation Rv1085c NC_002945.3 Mycobrowser_v2 CDS 1211955 1212743 . + 0 Mb1115 SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) (Z-FPP SYNTHETASE) (Z-FARNESYL DIPHOSPHATE SYNTHETASE) (GERANYLTRANSTRANSFERASE) (FARNESYL PYROPHOSPHATE SYNTHETASE) Mb1115, -, len: 262 aa. Equivalent to Rv1086, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 262 aa overlap). Short (C15) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.10) (see citations below), equivalent to NP_302598.1|NC_002677 possible undecaprenyl pyrophosphate synthetase from Mycobacterium leprae (262 aa), similar to many hypothetical proteins and several potential members of the upp synthase family e.g. NP_296167.1|NC_001263 undecaprenyl diphosphate synthase from Deinococcus radiodurans (339 aa); P20182|YT14_STRFR Hypothetical protein from Streptomyces fradiae (259 aa), FASTA scores: opt: 840, E(): 0, (51.0% identity in 259 aa overlap); and P38118|YARF_CORGL Hypothetical protein from Corynebacterium glutamicicum (234 aa), FASTA scores: opt: 729, E(): 0, (56.0% identity in 209 aa overlap); etc. Also similar to Rv2361c|MTCY27.19 (296 aa) (35.6% identity in 233 aa overlap). Contains PS01066 Uncharacterized protein family UPF0015 signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY. X2BH82,Q7U0P8 No cell wall and cell processes Rv1086 NC_002945.3 Mycobrowser_v2 CDS 1212920 1215244 . + 0 Mb1116 PE_PGRS21 pe-pgrs family protein pe_pgrs21 Mb1116, PE_PGRS21, len: 774 aa. Similar to Rv1087,len: 767 aa, from Mycobacterium tuberculosis strain H37Rv,(96.8% identity in 783 aa overlap). Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv1090|AL021897|MTV017_43 Mycobacterium tuberculosis H37Rv (853 aa), FASTA scores: opt: 2819, E(): 0, (59.8% identity in 860 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1 near C -terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 3 bp (*-gcg) and 45 bp, and deletions of 18 bp and 9 bp (ggtggggcc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa). Q7U0P7 No NC_002945.3 Mycobrowser_v2 CDS 1217850 1220402 . + 0 Mb1121 PE_PGRS22 pe-pgrs family protein pe_pgrs22 Mb1121, PE_PGRS22, len: 850 aa. Equivalent to Rv1091, len: 853 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 853 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv1087|AL021897|MTV017_39 Mycobacterium tuberculosis H37Rv (767 aa), FASTA scores: opt: 2819, E(): 0, (60.0% identity in 860 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (ccggcggca-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa). Q7U0P1 No NC_002945.3 Mycobrowser_v2 CDS 1220620 1221558 . - 0 Mb1122c coaA Probable pantothenate kinase coaA (Pantothenic acid kinase) Mb1122c, coaA, len: 312 aa. Equivalent to Rv1092c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 312 aa overlap). Probable coaA,pantothenate kinase (EC 2.7.1.33), similar to many e.g. P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores :opt: 1079, E(): 0, (52.7% identity in 311 aa overlap). Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae (312 aa) (93.6% identity in 312 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.912. BELONGS TO THE PANTOTHENATE KINASE FAMILY. X2BGW8,P63811 No NC_002945.3 Mycobrowser_v2 CDS 1221946 1223226 . + 0 Mb1123 glyA1 serine hydroxymethyltransferase 1 glya1 Mb1123, glyA1, len: 426 aa. Equivalent to Rv1093,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 426 aa overlap). Probable glyA1, serine hydroxymethyltransferase 1 (EC 2.1.2.1), equivalent to AL049491|MLCB1222_16 from Mycobacterium leprae (426 aa),FASTA score: (89.9 % identity in 426 aa overlap). Also similar to many e.g. P34895|GLYA_HYPME HYPHOMICROBIUM METHYLOVORUM (434 aa), FASTA scores: opt: 1492, E(): 0,(56.8% identity in 419 aa overlap); etc. BELONGS TO THE SHMT FAMILY. Note that previously known as glyA. X2BH08,P59953 No NC_002945.3 Mycobrowser_v2 CDS 1223331 1224158 . + 0 Mb1124 desA2 POSSIBLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA2 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) Mb1124, desA2, len: 275 aa. Equivalent to Rv1094,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Possible desA2,acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.19.2), equivalent to AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa),FASTA score: (78.1% identity in 274 aa overlap). Also weakly similar to plant stearoyl-acyl carrier protein desaturases, and very similar to U49839|MTV043.16C|Rv0824c enzyme desA1 from Mycobacterium tuberculosis (338 aa),FASTA scores: opt: 525, E(): 8.5e-30, (32.2% identity in 270 aa overlap); and to U15182|MLU15182_32 acyl-carrier protein desaturase precursor from Mycobacterium leprae (338 aa), FASTA scores: opt: 506, E(): 1.9e-28, (34.1% identity in 261 aa overlap). TBparse score is 0.894. Q7U0P0 No NC_002945.3 Mycobrowser_v2 CDS 1224369 1225670 . + 0 Mb1125 phoH2 PROBABLE PHOH-LIKE PROTEIN PHOH2 (PHOSPHATE STARVATION-INDUCIBLE PROTEIN PSIH) Mb1125, phoH2, len: 433 aa. Equivalent to Rv1095,len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 433 aa overlap). Probable phoH2,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein. Equivalent to AL049491 MLCB1222_14 Mycobacterium leprae (433 aa) (92.8% identity in 432 aa overlap). Similar to many proteins described as PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442 aa), FASTA scores: opt: 605, E(): 0, (40.1% identity in 444 aa overlap); or Mycobacterium tuberculosis Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352 aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOH FAMILY. Q7U0N9 No NC_002945.3 Mycobrowser_v2 CDS 1225757 1226632 . + 0 Mb1126 POSSIBLE GLYCOSYL HYDROLASE Mb1126, -, len: 291 aa. Equivalent to Rv1096, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 291 aa overlap). Possible glycosyl hydrolase (EC 3.-.-.-), possibly a deacetylase or esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3% identity in 289 aa overlap). Similar at the C-terminus of enzymes involved in carbohydrate degradation including Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog yjeA from Bacillus subtilis (467 aa), FASTA scores: opt: 418, E(): 2.6e-17, (38.6% identity in 184 aa overlap); M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces lividans (335 aa), FASTA scores: opt: 371, E(): 1.1e-14, (31.6% identity in 237 aa overlap); NP_345933.1|NC_003028 peptidoglycan N-acetylglucosamine deacetylase A from Streptococcus pneumoniae (463 aa); etc. Has possible N-terminal signal sequence with TMhelix at aa 13-31. Q7U0N8 No intermediary metabolism and respiration Rv1096 NC_002945.3 Mycobrowser_v2 CDS 1226635 1227516 . - 0 Mb1127c PROBABLE MEMBRANE GLYCINE AND PROLINE RICH PROTEIN Mb1127c, -, len: 293 aa. Equivalent to Rv1097c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 293 aa overlap). Probable membrane Gly-, Pro-rich protein, similar to Mycobacterium tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA scores: opt: 219, E(): 0.023, (30.5% identity in 266 aa overlap); and Rv2507. Contains potential membrane spanning region (aa ~68-92). TBparse score is 0.912. Q7U0N7 No cell wall and cell processes Rv1097c NC_002945.3 Mycobrowser_v2 CDS 1227513 1228937 . - 0 Mb1128c fum PROBABLE FUMARASE FUM (Fumarate hydratase) Mb1128c, fum, len: 474 aa. Equivalent to Rv1098c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 474 aa overlap). Probable fum, fumarase (EC 4.2.1.2). Equivalent to AL049491|MLCB1222_11 Mycobacterium leprae (474 aa) (89.5 % identity in 467 aa overlap). Similar to many e.g. P14408|FUMH_RAT FUMARATE HYDRATASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus (507 aa), FASTA scores: opt: 1427, E(): 0, (52.3% identity in 461 aa overlap); and P05042|FUMC_ECOLI Fumarate hydratase class II from Escherichia coli (467 aa), FASTA scores: opt: 1355, E(): 0, (50.2% identity in 444 aa overlap). Contains PS00163 Fumarate lyases signature. TBparse score is 0.886. X2BH10,Q7U0N6 No NC_002945.3 Mycobrowser_v2 CDS 1228968 1229954 . - 0 Mb1129c glpx fructose 1,6-bisphosphatase glpx Mb1129c, -, len: 328 aa. Equivalent to Rv1099c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 328 aa overlap). Conserved hypothetical protein, highly similar to P44811|GLPX_HAEIN GLPX PROTEIN HOMOLOG (believed to be involved in glycerol metabolism) (333 aa), FASTA scores: opt: 763, E():0, (46.2% identity in 327 aa overlap); and Q03224|YWJI_BACSU hypothetical protein from Bacillus subtilis (321aa ), FASTA scores: opt: 1092, E(): 0, (52.1% identity in 313 aa overlap). Equivalent to AL049491|MLCB1222_10 Mycobacterium leprae (355 aa), (93.0% identity in 328 aa overlap). X2BHA1,Q7U0N5 No intermediary metabolism and respiration Rv1099c NC_002945.3 Mycobrowser_v2 CDS 1230763 1231791 . - 0 Mb1131c CONSERVED MEMBRANE PROTEIN Mb1131c, -, len: 342 aa. Equivalent to 3' end of Rv1101c, len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 342 aa overlap). Conserved membrane protein, shows some similarity to other bacterial proteins e.g. P77406|PERM_ECOLI PUTATIVE PERMEASE PERM from Escherichia coli (353 aa), FASTA scores: opt: 287, E(): 8.8e-12, (24.9% identity in 349 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Q7U0N3 No NC_002945.3 Mycobrowser_v2 CDS 1232031 1232342 . - 0 Mb1132c mazf3 toxin mazf3 Mb1132c, -, len: 103 aa. Equivalent to Rv1102c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 103 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protens e.g. Rv1942c|MTCY9F9_22 (109 aa),FASTA scores: opt: 158, E(): 3.6e-05, (33.3% identity in 93 aa overlap); Rv0659c|MTCI376_17 (102aa), opt: 140, E(): 0.00072, (40.6% identity in 69aa overlap); and Rv1495. Q7U0N2 No virulence, detoxification, adaptation Rv1102c NC_002945.3 Mycobrowser_v2 CDS 1232342 1232662 . - 0 Mb1133c maze3 possible antitoxin maze3 Mb1133c, -, len: 106 aa. Equivalent to Rv1103c,len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 106 aa overlap). Conserved hypothetical protein, similar to part of Mycobacterium tuberculosis hypothetical protein Rv2472|AL021246|MTV008_27 Mycobacterium tuberculosis (97 aa), FASTA score: opt: 135,E(): 0.0091, (45.8% identity in 72 aa overlap). TBparse score is 0.916. Q7U0N1 No virulence, detoxification, adaptation Rv1103c NC_002945.3 Mycobrowser_v2 CDS 1232672 1233361 . + 0 Mb1134 POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) Mb1134, -, len: 229 aa. Equivalent to Rv1104, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 229 aa overlap). Possible para-nitrobenzyl esterase (fragment; possibly first part) (EC 3.1.1.-). Similar to the N-terminal domain of many e.g. P37967|PNBA_BACSU Bacillus subtilis (489 aa), FASTA scores: opt: 715, E(): 0, (53.4% identity in 191 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing in MTV017.58|Rv1105. Q7U0N0 No intermediary metabolism and respiration Rv1104 NC_002945.3 Mycobrowser_v2 CDS 1233682 1234197 . + 0 Mb1135 POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) Mb1135, -, len: 171 aa. Equivalent to Rv1105, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Possible para-nitrobenzyl esterase (fragment; possibly second part) (EC 3.1.1.-). Similar to C-terminal domain of many e.g. P71048 PARA-NITROBENZYL ESTERASE from Bacillus subtilis (489 aa), FASTA scores: opt: 248, E(): 2.7e-10, (32.3% identity in 167 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing from MTV017.57|Rv1104. Start changed since first submission. Q7U0M9 No intermediary metabolism and respiration Rv1105 NC_002945.3 Mycobrowser_v2 CDS 2065193 2065870 . + 0 Mb1861 CONSERVED HYPOTHETICAL PROTEIN Mb1861, -, len: 225 aa. Equivalent to Rv1830, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein MLCB1788.33c|AL008609|O32916 (231 aa), FASTA scores: opt: 1307, E(): 0, (89.6% identity in 231 aa overlap). X2BJB4,P67672 No conserved hypotheticals Rv1830 NC_002945.3 Mycobrowser_v2 CDS 1238580 1239563 . - 0 Mb1141c CONSERVED HYPOTHETICAL PROTEIN Mb1141c, -, len: 327 aa. Equivalent to Rv1111c,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 327 aa overlap). Conserved hypothetical protein, N-terminal domain is hydrophobic, C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. Q7U0M6 No conserved hypotheticals Rv1111c NC_002945.3 Mycobrowser_v2 CDS 1234215 1235327 . - 0 Mb1136c 3-beta-hydroxysteroid dehydrogenase Mb1136c, -, len: 370 aa. Equivalent to Rv1106c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 370 aa overlap). Probable cholesterol dehydrogenase (EC 1.1.1.-). Equivalent to AL049491|MLCB1222_7 Mycobacterium leprae (376 aa ) (75.5% identity in 375 aa overlap). Highly similar to Q03704 NAD(P)-dependent cholesterol dehydrogenase from Nocardia sp. (364 aa), FASTA scores: opt: 1789, E(): 0, (74.5% identity in 361 aa overlap). Also similar to U32426|MCU32426_1 3-beta-hydroxy-Delta5-steroid dehydrogenase from Molluscum contagiosum virus (354 aa),FASTA scores: opt: 432, E(): 1.7e-22, (34.6% identity in 347 aa overlap). Also similar to series of Mycobacterium tuberculosis hypothetical proteins described as sugar epimerases or dehydratases e.g. Rv3634c, Rv3784, Rv3464,etc. Q7U0M8 No intermediary metabolism and respiration Rv1106c NC_002945.3 Mycobrowser_v2 CDS 1235337 1235594 . - 0 Mb1137c xseB Probable exodeoxyribonuclease VII (small subunit) xseB (Exonuclease VII small subunit) Mb1137c, xseB, len: 85 aa. Equivalent to Rv1107c,len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 85 aa overlap). Probable xseB,exonuclease VII small subunit (EC 3.1.11.6). Equivalent to AL049491|MLCB1222_6 Mycobacterium leprae (87 aa) (77.9% identity in 68 aa overlap). Similar to P43914|EX7S_HAEIN EXODEOXYRIBONUCLEASE SMALL SUBUNIT from H. influenzae (84 aa), FASTA scores: opt: 126, E(): 0.006, (37.3% identity in 67 aa overlap); and P22938|EX7S_ECOLI EXODEOXYRIBONUCLEASE SMALL SUBUNIT from Escherichia coli (79 aa), FASTA scores: opt: 125, E(): 0.0067, (39.7% identity in 58 aa overlap). BELONGS TO THE XSEB FAMILY. X2BGY7,P67457 No NC_002945.3 Mycobrowser_v2 CDS 1235584 1236831 . - 0 Mb1138c xseA PROBABLE EXODEOXYRIBONUCLEASE VII (LARGE SUBUNIT) XSEA (EXONUCLEASE VII LARGE SUBUNIT) Mb1138c, xseA, len: 415 aa. Equivalent to Rv1108c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). Probable xseA,exodeoxyribonuclease VII large subunit (EC 3.1.11.6) (see first citation below). Equivalent to AL049491|MLCB1222_5 Mycobacterium leprae (428 aa) (81.5% identity in 411 aa overlap). Similar to many e.g. P04994|EX7L_ECOLI exodeoxyribonuclease large subunit from Escherichia coli (456 aa), FASTA scores: opt: 581, E(): 1.6 e-30, (30.8% identity in 425 aa overlap); also similar to the exodeoxyribonuclease in Bacillus subtilis, H. influenzae and H. pylori. TBparse score is 0.890. BELONGS TO THE XSEA FAMILY. X2BH15,P67448 No NC_002945.3 Mycobrowser_v2 CDS 1236828 1237466 . - 0 Mb1139c conserved protein Mb1139c, -, len: 212 aa. Equivalent to Rv1109c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 212 aa overlap). Conserved hypothetical protein, N-terminal domain is hydrophobic, C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. TBparse score is 0.934. Q7U0M7 No conserved hypotheticals Rv1109c NC_002945.3 Mycobrowser_v2 CDS 1237556 1238563 . + 0 Mb1140 lytB2 PROBABLE LYTB-RELATED PROTEIN LYTB2 Mb1140, lytB2, len: 335 aa. Equivalent to Rv1110,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 335 aa overlap). Probable lytB2,LytB-related protein, equivalent to AL049491|MLCB1222_3 from Mycobacterium leprae (335 aa), FASTA score: (82.9% identity in 333 aa overlap). Also similar to LytB proteins from many bacteria (appears to have N-terminal extension) e.g. P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB PROTEIN from Escherichia coli strains K12 and O157:H7 (316 aa),FASTA scores: opt: 1041, E():0, (52.4% identity in 309 aa overlap); etc. Also very similar to another LytB-related protein from Mycobacterium tuberculosis: LytB1|Rv3382c|MTV004.40c (329 aa), FASTA scores: opt: 975,E(): 0, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY. X2BH45,P0A5I1 No NC_002945.3 Mycobrowser_v2 CDS 1239626 1240699 . + 0 Mb1142 Probable GTP binding protein Mb1142, -, len: 357 aa. Equivalent to Rv1112, len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 357 aa overlap). Probable GTP binding protein, similar to YCHF_HAEIN|P44681 probable gtp-binding protein (362 aa), FASTA scores: opt: 1189, E(): 0, (52.7% identity in 357 aa overlap). Equivalent to AL049491|MLCB1222_1 hypothetical protein from Mycobacterium leprae (356 aa) (85.9% identity in 354 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7VEZ6 No conserved hypotheticals Rv1112 NC_002945.3 Mycobrowser_v2 CDS 1240787 1240984 . + 0 Mb1143 vapb32 possible antitoxin vapb32 Mb1143, -, len: 65 aa. Equivalent to Rv1113, len: 65 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 65 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2758c|AL00896 7|MTV002.23 (88 aa) FASTA scores: opt: 97, E(): 0.86, (33.3% identity in 69 aa overlap). Part of family including Rv2871, Rv1241, Rv2132,Rv3321c, etc. Q7U0M5 No virulence, detoxification, adaptation Rv1113 NC_002945.3 Mycobrowser_v2 CDS 1240981 1241355 . + 0 Mb1144 vapc32 possible toxin vapc32. contains pin domain. Mb1144, -, len: 124 aa. Equivalent to Rv1114, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Conserved hypothetical protein, slight similarity to Mycobacterium tuberculosis hypothetical proteins MTCY159.08c (33.0% identity in 115 aa overlap); Rv1561 and Rv2010. Q7U0M4 No virulence, detoxification, adaptation Rv1114 NC_002945.3 Mycobrowser_v2 CDS 1241558 1242256 . + 0 Mb1145 POSSIBLE EXPORTED PROTEIN Mb1145, -, len: 232 aa. Equivalent to Rv1115, len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 232 aa overlap). Possible exported protein, contains possible N-terminal signal sequence. Q7U0M3 No cell wall and cell processes Rv1115 NC_002945.3 Mycobrowser_v2 CDS 1242374 1242559 . + 0 Mb1146 HYPOTHETICAL PROTEIN Mb1146, -, len: 61 aa. Equivalent to Rv1116, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 61 aa overlap). Hypothetical unknown protein. Q7U0M2 No conserved hypotheticals Rv1116 NC_002945.3 Mycobrowser_v2 CDS 1242486 1242761 . - 0 Mb1147c CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) Mb1147c, -, len: 91 aa. Equivalent to Rv1116A, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 91 aa overlap). Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of Rv1646|Z85982_9 from Mycobacterium tuberculosis (310 aa),FASTA scores: opt: 301, E(): 9.3e-13, (68.05% identity in 72 aa overlap). Also overlaps gene on other strand,Rv1116, at 3'-end. Q7U0M1 No conserved hypotheticals Rv1116A NC_002945.3 Mycobrowser_v2 CDS 1244381 1244875 . - 0 Mb1151c CONSERVED HYPOTHETICAL PROTEIN Mb1151c, -, len: 164 aa. Equivalent to Rv1120c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Conserved hypothetical protein, some similarity at C-terminus to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1890c|MTCY180.28 (462 aa), FASTA scores: opt: 187, E(): 2.2e-05, (36.6% identity in 93 aa overlap) and Rv2488c|YZ19_MYCTU|Q10551 (285 aa), FASTA scores: opt: 156, E(): 0.00074, (32.7% identity in 107 aa overlap). Q7U0L8 No conserved hypotheticals Rv1120c NC_002945.3 Mycobrowser_v2 CDS 2186604 2186981 . - 0 Mb1978c maze5 possible antitoxin maze5 Mb1978c, -, len: 125 aa. Equivalent to Rv1943c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Conserved hypothetical protein, showing some similarity with Rv1946c|MTCY09F9.18|lppG possible conserved lipoprotein from Mycobacterium tuberculosis (150 aa), FASTA score: (71.4% identity in 28 aa overlap). Q7TZ89 No virulence, detoxification, adaptation Rv1943c NC_002945.3 Mycobrowser_v2 CDS 1252988 1254343 . - 0 Mb1159c CONSERVED HYPOTHETICAL PROTEIN Mb1159c, -, len: 451 aa. Equivalent to Rv1128c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 451 aa overlap). Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc. Q7U0L1 No insertion seqs and phages Rv1128c NC_002945.3 Mycobrowser_v2 CDS 1245078 1246478 . + 0 Mb1152 zwf1 PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF1 (G6PD) Mb1152, zwf1, len: 466 aa. Equivalent to Rv1121,len: 466 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 466 aa overlap). Probable zwf1,glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), highly similar to many e.g. G6PD_E COLI|P22992 Escherichia coli (491 aa), FASTA scores: opt: 642, E(): 0, (35.8% identity in 478 aa overlap). Mycobacterium tuberculosis has two genes for ZWF, this one is highly divergent. BELONGS TO THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY. Note that previously known as zwf. X2BH05,P0A587 No intermediary metabolism and respiration Rv1121 NC_002945.3 Mycobrowser_v2 CDS 1246500 1247522 . + 0 Mb1153 gnd2 probable 6-phosphogluconate dehydrogenase,decarboxylating gnd2 Mb1153, gnd2, len: 340 aa. Equivalent to Rv1122,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 340 aa overlap). Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44), highly similar to Q53917 6-PHOSPHOGLUCONATE DEHYDROGENASE from Streptomyces coelicolor (291 aa), fasta scores: opt: 431, E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive organisms. BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY. Q7U0L7 No intermediary metabolism and respiration Rv1122 NC_002945.3 Mycobrowser_v2 CDS 1247515 1248423 . - 0 Mb1154c bpoB POSSIBLE PEROXIDASE BPOB (NON-HAEM PEROXIDASE) Mb1154c, bpoB, len: 302 aa. Equivalent to Rv1123c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 302 aa overlap). Possible bpoB,peroxidase (non-haem peroxidase) (EC 1.11.1.-), with some similarity to a range of enzymes from several organisms including: DEH1_MORSP|Q01398 haloacetate dehalogenase (EC 3.8.1.3) from Moraxella sp. (294 aa), FASTA scores: opt: 201, E(): 2.1e-06, (35.8% identity in 134 aa overlap); and BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 (EC 1.11.1.-) from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 187, E(): 1.6e-05, (23.1% identity in 281 aa overlap). Similar to several other Mycobacterium tuberculosis proteins, probable epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c,Rv3171c, etc. Contains PS00216 Sugar transport proteins signature 1. Q7U0L6 No NC_002945.3 Mycobrowser_v2 CDS 1248498 1249448 . + 0 Mb1155 ephC PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE) Mb1155, ephC, len: 316 aa. Equivalent to Rv1124,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 316 aa overlap). Probable ephC, epoxide hydrolase (EC 3.3.2.3) (see citation below), similar to Q42566 epoxide hydrolase from Arabidopsis thaliana (321 aa), FASTA scores: opt: 298, E(): 8.2e-13, (27.6% identity in 333 aa overlap). Similar to other Mycobacterium tuberculosis epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3670, Rv3473c,etc. Q7U0L5 No virulence, detoxification, adaptation Rv1124 NC_002945.3 Mycobrowser_v2 CDS 1249453 1250697 . + 0 Mb1156 CONSERVED HYPOTHETICAL PROTEIN Mb1156, -, len: 414 aa. Equivalent to Rv1125, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 414 aa overlap). Conserved hypothetical protein. Similar to AL133278|SCM11.13 hypothetical protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 182, E(): 0.0005, (28.1% identity in 437 aa overlap). Q7U0L4 No conserved hypotheticals Rv1125 NC_002945.3 Mycobrowser_v2 CDS 1250701 1251306 . - 0 Mb1157c conserved protein Mb1157c, -, len: 201 aa. Equivalent to Rv1126c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Conserved hypothetical protein, similar in N-terminus to O05567|MLCB33.17 hypothetical protein from Mycobacterium leprae (141 aa),FASTA scores: opt: 332, E(): 1.4e-23, (58.4% identity in 101 aa overlap). Q7U0L3 No conserved hypotheticals Rv1126c NC_002945.3 Mycobrowser_v2 CDS 1251303 1252775 . - 0 Mb1158c ppdK PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK Mb1158c, ppdK, len: 490 aa. Equivalent to Rv1127c,len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 490 aa overlap). Probable ppdK,Pyruvate, phosphate dikinase (EC 2.7.9.1). Equivalent (but shorter) to Z94723|MLCB33_16 ppdK from Mycobacterium leprae (601 aa) (71.8% identity in 478 aa overlap). Highly similar to N-terminus of PODK_CLOSY|P22983 pyruvate,phosphate dikinase from Clostridium symbiosum (873 aa),FASTA scores: opt: 786, E(): 0, (37.4% identity in 514 aa overlap). Q7U0L2 No NC_002945.3 Mycobrowser_v2 CDS 1254445 1255905 . - 0 Mb1160c PROBABLE TRANSCRIPTIONAL REGULATOR PROTEIN Mb1160c, -, len: 486 aa. Equivalent to Rv1129c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 486 aa overlap). Possible transcriptional regulator protein, similar to Rv0465c|MTV038.09c Mycobacterium tuberculosis (474 aa),FASTA scores: E(): 0, (47.4% identity in 468 aa overlap). Helix turn helix motif present from aa 32-53. Q7U0L0 No regulatory proteins Rv1129c NC_002945.3 Mycobrowser_v2 CDS 1255926 1257506 . + 0 Mb1161 prpd possible methylcitrate dehydratase prpd Mb1161, -, len: 526 aa. Equivalent to Rv1130, len: 526 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 526 aa overlap). Conserved hypothetical protein, some similarity to AP000063|AP000063_192 hypothetical protein from Aeropyrum pernix (479 aa), FASTA scores: opt: 717, E(): 0, (34.3% identity in 443 a a overlap), and to PRPD_ECOLI|P77243 prpd protein from Escherichia coli (483aa), FASTA scores: opt: 234, E(): 3.3e-08, (27.0% identity in 429 aa overlap). Q7U0K9 No intermediary metabolism and respiration Rv1130 NC_002945.3 Mycobrowser_v2 CDS 1257503 1258684 . + 0 Mb1162 prpc probable methylcitrate synthase prpc Mb1162, gltA1, len: 393 aa. Equivalent to Rv1131,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Probable gltA1, citrate synthase 1 (EC 4.1.3.7), highly similar to CISY_MYCSM|P26491 citrate synthase from Mycobacterium smegmatis (375 aa), FASTA scores: opt:1942, E(): 0, (80.0% identity in 375 aa overlap). Also similar to two other M. tuberculosis citrate synthases, Rv0896c|MTCY31.24|gltA2 (431 aa), FASTA score: (33.1% identity in 381 aa overlap) and Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (31.8% identity in 371 aa overlap). Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY. Q7U0K8 No NC_002945.3 Mycobrowser_v2 CDS 1258696 1260426 . + 0 Mb1163 CONSERVED MEMBRANE PROTEIN Mb1163, -, len: 576 aa. Equivalent to Rv1132, len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 576 aa overlap). Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa), fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap). Q7U0K7 No cell wall and cell processes Rv1132 NC_002945.3 Mycobrowser_v2 CDS 1269574 1270380 . - 0 Mb1173c echA11 PROBABLE ENOYL-COA HYDRATASE ECHA11 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) Mb1173c, echA11, len: 268 aa. Equivalent to Rv1141c, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 268 aa overlap). Probable echA11, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. P24162|ECHH_RHOCA PROBABLE ENOYL-COA HYDRATASE from Rhodobacter capsulatus (257 aa); CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa), FASTA scores: opt: 513, E(): 1e-25, (36.1% identity in 249 aa overlap); etc. Also similarity with naphthoate synthases. Also highly similar to downstream ORF Rv1142c|MTCI65.09|echA10 PROBABLE ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (268 aa), FASTA scores: opt: 1225, E(): 0, (72.3% identity in 267 aa overlap). Q7U0J8 No lipid metabolism Rv1141c NC_002945.3 Mycobrowser_v2 CDS 1260438 1262717 . - 0 Mb1164c metE PROBABLE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE METE (methionine synthase, vitamin-B12 independent isozyme) Mb1164c, metE, len: 759 aa. Equivalent to Rv1133c,len: 759 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 759 aa overlap). Probable metE,5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14), highly similar to others e.g. METE_ECOLI|P25665 Escherichia coli (752 aa), FASTA scores: opt: 2251, E(): 0, (48.1% identity in 756 aa overlap). Equivalent to Z94723|MLCB33_14 metE from M. leprae (760 aa) (85.3% identity in 755 aa overlap). BELONGS TO THE VITAMIN-B12 INDEPENDENT METHIONINE SYNTHASE FAMILY. X2BHF0,P65341 No NC_002945.3 Mycobrowser_v2 CDS 1263643 1265499 . - 0 Mb1166c PPE16 ppe family protein ppe16 Mb1166c, PPE16, len: 618 aa. Equivalent to Rv1135c,len: 618 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 618 aa overlap). Member of the M. tuberculosis PPE family of glycine-rich proteins. Similar to Rv2356c (59.6% identity in 627 aa overlap); etc. Q7U0K5 No NC_002945.3 Mycobrowser_v2 CDS 1266843 1267859 . - 0 Mb1170c possible oxidoreductase Mb1170c, -, len: 338 aa. Equivalent to Rv1138c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 338 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to Q9EWQ8 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89, E(): 4.5e-09, (24.6% identity in 358 aa overlap). Q7U0K1 No intermediary metabolism and respiration Rv1138c NC_002945.3 Mycobrowser_v2 CDS 1267856 1268356 . - 0 Mb1171c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Mb1171c, -, len: 166 aa. Equivalent to Rv1139c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 166 aa overlap). Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein, YBPQ (168 aa),FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740, Rv0750. Q7U0K0 No cell wall and cell processes Rv1139c NC_002945.3 Mycobrowser_v2 CDS 1268718 1269566 . + 0 Mb1172 PROBABLE INTEGRAL MEMBRANE PROTEIN Mb1172, -, len: 282 aa. Equivalent to Rv1140, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 282 aa overlap). Probable integral membrane protein. Weak similarity in C-terminus to hypothetical Escherichia coli proteins YPRA and YPRB,possibly membrane-bound e.g. YPRA_ECOLI HYPOTHETICAL 24.3 KD PROTEIN (URF 1) (217 aa), FASTA scores: opt: 166, E(): 0.00062, (31.0% identity in 158 aa overlap). Q7U0J9 No cell wall and cell processes Rv1140 NC_002945.3 Mycobrowser_v2 CDS 2193772 2194221 . + 0 Mb1991 higa possible antitoxin higa Mb1991, -, len: 149 aa. Equivalent to Rv1956, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Possible transcriptional regulatory protein, contains probable helix-turn-helix motif at aa 52-73 (+4.78 SD). Q7TZ76 No virulence, detoxification, adaptation Rv1956 NC_002945.3 Mycobrowser_v2 CDS 1279641 1280189 . + 0 Mb1181 POSSIBLE TRANSPOSASE (FRAGMENT) Mb1181, -, len: 183 aa. Equivalent to Rv1150, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 183 aa overlap). Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of putative Mycobacterium tuberculosis IS element (308 aa), FASTA scores: opt: 959, E(): 0,(99.3% identity in 145 aa overlap). The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08. TBparse score is 0.914. No insertion seqs and phages Rv1150 NC_002945.3 Mycobrowser_v2 CDS 1270523 1271329 . - 0 Mb1174c echA10 PROBABLE ENOYL-CoA HYDRATASE ECHA10 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) Mb1174c, echA10, len: 268 aa. Equivalent to Rv1142c, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 268 aa overlap). Probable echA10, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa), FASTA scores: opt: 525, E(): 1.3e-26, (35.1% identity in 251 aa overlap); NP_420658.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (267 aa); NP_438092.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (263 aa); etc. Also similarity with naphthoate synthases. Also highly similar to upstream ORF Rv1141c|MTCI65.08c|echA11 PROBABLE ENOYL-CoA HYDRATASE from Mycobacterium tuberculosis (268 aa), FASTA score: opt: 1225, E(): 0, (72.3% identity in 267 aa overlap). TBparse score is 0.891. Q7U0J7 No lipid metabolism Rv1142c NC_002945.3 Mycobrowser_v2 CDS 1271433 1272515 . + 0 Mb1175 mcr PROBABLE ALPHA-METHYLACYL-COA RACEMASE MCR (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) Mb1175, mcr, len: 360 aa. Equivalent to Rv1143,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable mcr,alpha-methylacyl-CoA racemase (EC 5.1.99.4). Strong similarity to other alpha-methylacyl-CoA racemases and also some similarity to L-carnitine dehydratase (EC 4.2.1.89) e.g. U89905|g1552373 methylacyl-CoA racemase alpha from Norway rat (361 aa), FASTA scores: opt: 1035,E():0, (47.2% identity in 339 aa overlap). Equivalent to (but longer than) Z94723|MLCB33_13 Mycobacterium leprae (253 aa) (85.3% identity in 245 aa overlap). Also similar to Mycobacterium tuberculosis putative racemases Rv0855,Rv1866, Rv3272. Q7U0J6 No lipid metabolism Rv1143 NC_002945.3 Mycobrowser_v2 CDS 2196911 2197183 . - 0 Mb1997A vapB35 Possible antitoxin VapB35 Mb1997A, len: 90 aa. Equivalent to Rv1962A len: 90 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB35,antitoxin,part of toxin-antitoxin (TA) operon with Rv1962c, see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. Rv3385c, Rv3407, Rv0626 X2BJ65 No virulence, detoxification, adaptation Rv1962A NC_002945.3 Mycobrowser_v2 CDS 1272527 1273279 . + 0 Mb1176 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Mb1176, -, len: 250 aa. Equivalent to Rv1144, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 250 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. NP_104056.1|NC_002678 3-hydroxyacyl-CoA dehydrogenase type II from Mesorhizobium loti (253 aa); NP_251244.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (255 aa); AAK15008.1|AF233685_1|AF233685 short chain L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus (261 aa); HSU73514|g1778354|XH98G2 human short-chain alcohol dehydrogenase from Homo sapiens (261 aa), FASTA scores: opt: 875, E(): 0, (60.1% identity in 253 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Q7U0J5 No intermediary metabolism and respiration Rv1144 NC_002945.3 Mycobrowser_v2 CDS 1273794 1276139 . + 0 Mb1177 mmpL13 probable conserved transmembrane transport protein mmpl13b Mb1177, mmpL13, len: 781 aa. Equivalent to Rv1145 and Rv1146, len: 303 aa and 470 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 284 aa overlap and 100% identity in 470 aa overlap). Probable mmpL13A, conserved transmembrane transport protein (see citation below), member of RND superfamily, showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. MTCY987|g1781238 from Mycobacterium tuberculosis (962 aa), FASTA scores: opt: 213, E(): 1.9e-06, (28.0% identity in 296 aa overlap); etc. Strong similarity to U92075|MMU92075_5 hypothetical protein from Mycobacterium marinum (256 aa), FASTA scores: opt: 957,E(): 0, (57.6% identity in 257 aa overlap). Should continue as mmpL13B|Rv1146, but frameshift required. Sequence has been checked and is identical in M. tuberculosis strain CDC1551, and Mycobacterium bovis strain AF2122/97 ????. BELONGS TO THE MMPL FAMILY. Probable mmpL13B, conserved transmembrane transport protein (see citation below), member of RND superfamily,showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. Q53902|C40046 antibiotic transport-associated protein from Streptomyces coelicolor (711 aa), FASTA scores: opt: 193, E(): 2.1e-05,(28.9% identity in 394 aa overlap); etc. Could be in frame with previous ORF mmpL13A|Rv1145, but no sequence error apparent to account for this; sequence is identical in Mycobacterium tuberculosis strain CDC1551. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-a) leads to a single product. Q7U0J4 No cell wall and cell processes Rv1145 NC_002945.3 Mycobrowser_v2 CDS 1276272 1276922 . + 0 Mb1178 conserved protein Mb1178, -, len: 216 aa. Equivalent to Rv1147, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 216 aa overlap). Conserved hypothetical protein, similar to many conserved hypothetical proteins,and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) from R. sphaeroides (203 aa), FASTA scores: opt: 156, E( ): 0.00073, (27.6% identity in 156 aa overlap). Q7U0J3 No conserved hypotheticals Rv1147 NC_002945.3 Mycobrowser_v2 CDS 1277672 1279120 . - 0 Mb1179c CONSERVED HYPOTHETICAL PROTEIN Mb1179c, -, len: 482 aa. Equivalent to Rv1148c,len: 482 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 482 aa overlap). Conserved hypothetical ORF in REP13E12 degenerate repeat, nearly identical to other hypothetical Mycobacterium tuberculosis proteins in REP13E12 repeats, although similarity extends upstream past proposed f-Met start. Very similar to other REP13E12 proteins e.g. Rv1945, Rv3467, Rv0094c, Rv1128c etc. X2BHH0,P0A5E0 No insertion seqs and phages Rv1148c NC_002945.3 Mycobrowser_v2 CDS 1280276 1280989 . - 0 Mb1182c transcriptional regulatory protein Mb1182c, -, len: 237 aa. Equivalent to Rv1151c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 237 aa overlap). Probable transcriptional regulatory protein, similar to others AE000776|AE000776_10 Aquifex aeolicus (239 aa), FASTA scores: opt: 725, E(): 0, (46.4% identity in 237 aa overlap); ECAE0002125|g1787358 Escherichia coli (279 aa),FASTA scores: opt: 464, E(): 1.3e-23, (36.7% identity in 240 aa overlap). X2BH48,P66814 No regulatory proteins Rv1151c NC_002945.3 Mycobrowser_v2 CDS 1281027 1281392 . + 0 Mb1183 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Mb1183, -, len: 121 aa. Equivalent to Rv1152, len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 121 aa overlap). Start uncertain. Probable transcriptional regulatory protein, some similarity to others e.g. YHCF_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR (121 aa), FASTA scores: opt: 187, E(): 1.9e-06, (34.9% identity in 106 aa overlap). TBparse score is 0.876. Helix turn helix motif from aa 42-63 (+3.10 SD). Q7U0J0 No regulatory proteins Rv1152 NC_002945.3 Mycobrowser_v2 CDS 1281370 1282218 . - 0 Mb1184c omt PROBABLE O-METHYLTRANSFERASE OMT Mb1184c, omt, len: 282 aa. Equivalent to Rv1153c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 282 aa overlap). Probable omt,O-methyltransferase (EC 2.1.1-), similar to TCMP_STRGA|P39887 Tetracenomycin polyketide synthesis O-methyltransferase tcmP (EC 2.1.1.-) from Streptomyces glaucescens (270 aa), FASTA scores: opt: 368, E(): 1.7e-17, (31.3% identity in 233 aa overlap). Q7U0I9 No NC_002945.3 Mycobrowser_v2 CDS 1300139 1300681 . - 0 Mb1200c PPE17b PPE FAMILY PROTEIN [SECOND PART] Mb1200c, PPE17b, len: 181 aa. Equivalent to 3' end of Rv1168c, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b. No NC_002945.3 Mycobrowser_v2 CDS 1282801 1283244 . + 0 Mb1186 p